Effectively leveraging fast networking and storage hardware for distributed data processing remains challenging. Often the hardware integration takes place too low in the stack, and as a result performance advantages are overshadowed by higher layer software overheads. Moreover, new opportunities for fundamental architectural changes within the data processing layer are not being explored. Crail is a user-level I/O architecture for the Apache data processing ecosystem, designed from the ground up for high-performance networking and storage hardware. With Crail, hardware performance advantages become visible at the application level and translate into workload runtime improvements. In this paper, we discuss the basic concepts of Crail and show how Crail impacts workloads in Spark, like sorting or SQL.


Mobile ad hoc networks (MANETs) face a number of challenges, in particular due to its dynamic network topology. A self organizing architecture can overcome the problem of changing topology and dynamic behavior of mobile nodes. Such a framework can be created either by using a virtual backbone that covers all nodes in the network or by partitioning the mobile nodes into clusters. The backbone and clustering organization are useful for collecting control traffic and thereby reducing the overhead of route discovery.


Wild Qilian Yellow Mushroom(QYM)is fund in Huangcaogou Qilian county Qinghai Province,It's flavour is delicious.It's texture is very fine.It's protein content is very high.People is like ate it.There are abundant varied chemical composition.Their physiological activity are able strengthen human body immunity and restrain grow of tumour.There are higher nutrition value and function of food therapy health protection.The purpose of analysis and study QYM is just proved theory foundation for exploit and utilize wild flora resources.


We present a case study that showcases the analysis of four snowstorms that occurred during the winter season of 2021‐2022 at Wallops Flight Facility. The study includes data collection and analysis from various instruments ranging from delicate optical, electronic, and mechanical surface instrumentation to state-of-the-art radars. Surface observations of geometrical and microphysical properties of winter precipitation coupled with radar scattering measurements and computations are crucial for the advancement of our understanding of snow events, numerical weather prediction models, and correct interpretation of data from the national network of weather radars.


The structure of 5,7,9,10-tetramethoxy-3-methyl-1H-naphtho[2,3-c]pyran-1-one, C 18 H 18 O 6 , a derivative of a natural isocoumarin isolated from Paepalanthus bromelioides, was determined by X-ray analysis, which unequivocally confirmed the previously assigned structure. Small deviations from the standard angles, resulting from steric hindrance between the methoxyl and carbonyl groups, were observed


The 13C-NMR chemical shifts of 112 sterols (4-demethyl-, 4-monomethyl-, and 4, 4-dimethylsterols) and triterpene alcohols, most of which are the naturally occurring ones, are listed and a number of methods for signal assignment are explained. The utility of 13C-NMR spectral analysis for the structure elucidation of these compounds is discussed.


Applications and Orbit Scenarios for a Multistatic InSAR Formation Flying Microsatellite Mission Erica H. Peterson Master of Applied Science Graduate Department of Aerospace Engineering University of Toronto 2008 The Space Flight Laboratory (SFL) at the University of Toronto Institute for Aerospace Studies is currently designing CanX-4 and CanX-5, a pair of formation-flying nanosatellites that will target centimeter-level position determination and sub-meter control. Once formation flight has been demonstrated, future missions can carry payloads designed to exploit these capabilities. Earth Observation is one such application that can benefit greatly from the availability of multiple platforms with precise position determination and attitude control. This work explores multistatic interferometric synthetic aperture radar (InSAR) as a particularly promising implementation of formation flight. Several mission scenarios are considered, including three commonly proposed InSAR constellation configurations, namely the Cartwheel, the Cross-Track Pendulum, and the Car-Pe configuration, as well as three large ( kilowatt) SAR transmitters (L-, Cand X-band) and one microsatellite transmitter (X-band, 150W). Using a framework of STK and MATLAB simulation and analysis tools, each case is evaluated with respect to the available interferometric baselines, ground coverage, resolution, and utility for selected applications including digital elevation modeling, moving target detection, and superresolution imagery. The "large" X-band transmitter is found to produce the most favorable operating area and resolution, and the Car-Pe configuration provides the greatest utility and flexibility for a combination of the three selected applications.


Self-reported psychological distress is quite common in the Swedish elderly population. Feelings of psychological distress may have devastating consequences. The overall aim of this study was to explore associations between socioeconomic position and work complexity during midlife with psychological distress in old age. Ordered logistic regression was used to investigate the associations between, (I) socioeconomic position during midlife and psychological distress in old age, (II) work complexity during midlife and psychological distress in old age, (III) the association between socioeconomic position and psychological distress independent of work complexity, and (IV) the association between work complexity and psychological distress independent of socioeconomic position. The results show that (I) higher socioeconomic position during midlife is associated with less psychological distress in old age (II) higher work complexity during midlife is associated with less psychological distress in old age, and that (III) higher work complexity is associated to less psychological distress independent of socioeconomic position, (IV) but the association between socioeconomic position and psychological distress diminishes adjusting for work complexity. The main conclusion from this study is that individuals with high socioeconomic position benefits from both their position in society and from their working conditions while individuals of lower socioeconomic position are more likely to also suffer the drawbacks of disadvantageous working conditions in relation to late life psychological distress.


It is too early to predict the long-term social consequences of the Republican electoral victory of 1994, but no one can deny the extent to which the terms of political debate have shifted rightward, toward the celebration of rugged individualism. Card-carrying liberals, as the label now effectively defines them, seem dazed by the speed with which Americans have sloughed off a century-old discourse of social reform and regulation. Yet even the most jaded intellectual historians have had to blink at the sight of a new conservative majority turning back the rhetorical clock from LBJ's Great Society to Graham Wallas's, and, even more dramatically, from FDR's Forgotten Man to William Graham Sumner's.


Research on the effect of volume of addition of milk of peas to cow milk yoghurt with variable of addition of milk of peas 0ml, 10ml, 20ml, 30ml, 40ml with difference of starter type (Lactobacillus burgaricus, starter powder, yoghurt plain) and time of storage. Yoghurt viscosity test, ph-test, and organoleptic test were performed. From the research results obtained the best viscosity by using starter lactobacillus is variable 2A of 16.5 Cp while the best organoleptic test yoghurt is variable 1A. For the type of starter powder obtained the best viscosity and organoleptic test is 1B variable of 8.1 Cp. While yoghurt with the addition of plain yoghurt obtained the best viscosity and organoleptic variable 1C 1.14 Cp. The best viscosity result is the addition of starter lactobacillus bulgaricus with the addition of 10ml peas milk.


In order to grasp properly the power generation performances of PEFC (Polymer Electrolyte Fuel Cell), it is necessary to know the water management data, such as diffusion coefficient of water vapor through MEA (Membrane Electrode Assembly) and GDL (Gas Diffusion Layer), and electro-osmotic coefficient of MEA, and to know power loss data, such as activation and resistance overpotentials. In this study we have measured these data to analyze our experimental results of PEFC power generation tests by our two-dimensional simulation code. These data were adopted in our simulation code. It is desirable to of develop the simulation code of PEFC power generation performance. By developing the simulation code of PEFC some experiments might be taken place by numerical simulations and could save the developing time and money. Therefore we have made a simulation code as a useful supporting tool of to develop PEFC. Our code considers simultaneously the mass, charge and energy conservation equations, and the equivalent electriccircuit for PEFC (Fig. 1) to get numerical distributions of hydrogen/oxygen concentrations, current density, cell potential, and gas/cell-component temperatures along gas flow. In this study current distributions of PEFC under a wide operating conditions have been calculated and compared with experimental distributions by our segmented electrode cell. The measured distributions under various operating conditions agreed well as shown in Fig. 2 with the calculated ones showing that our code is verified experimentally. The current distributions shown in Fig. 2 were measured at an operating condition of low dew point temperature, medium O2 utilization ratio and co-flow type. In this condition the membrane resistance is high at cell entrance due to the dry anode and cathode gases, and at the middle of the cell the membrane is humidified by the generated water, keeping the same resistance along flow direction until the cell outlet. The concentration overpotential through GDL was also estimated by the parallel fine pores model, however the estimated concentration overpotential was very small to be neglected in the power generating performance of PEFC.


In conventional battery systems, single weak cells are limiting the overall performance or are critical for the battery's safety. In intelligent battery systems, reconfiguration enables the individual handling of single cells in the system by Bad-Block-Management (BBM). Thereby, the thermal situation within the battery is changed by the combination of the thermal influence by weak cells and the reconfiguration procedures by BBM. For an optimal reconfiguration strategy, multiple aspects need to be considered such as the cell individual parameters, safety state and position. In this work, the thermal effects of various BBM scenarios under electric vehicle conditions are investigated on the example of an intelligent lithium-ion module made of 12 prismatic cells. A hardware prototype of an intelligent module with switchable cells is investigated experimentally to quantify the effects of reconfiguration and provide validation data for the model development. The model is based on electro-thermal coupling of a 3D lumped thermal model and an equivalent circuit model of the cell with electronics and reconfiguration functionality. The model is used to investigate the temperature distribution with weaks cells within the module and the effects of several associated BBM procedures.


On Sunday, March 7, 1965, in Selma, Alabama, 600 supporters of African American voting rights marched, two abreast, across the steeply arched Edmund Pettus Bridge. Awaiting them at the bridge's eastern end were scores of mounted Alabama state troopers and Dallas County police. When the marchers refused an order to disperse, the officers attacked, firing dozens of canisters of tear gas and smoke into the crowd and beating the demonstrators as they fled. That evening, film footage of the brutal attack was broadcast nationwide, transforming Selma into a symbol of violent white opposition to the civil rights movement.1 Two and a half years later, the violence of "Bloody Sunday" repeated itself, but this time it occurred beyond Dixie's borders. On Tuesday, August 29, 1967, in Milwaukee, Wisconsin, some 200 advocates of open housing marched across the Sixteenth Street Viaduct, which separated the city's black community from several white ethnic communities. Not long after the demonstrators crossed the span, a riotous mob of more than 1,000 whites attacked. The brutality of the assault reminded observers of "Bloody Sunday" and earned Milwaukee the designation "The Selma of the North." Milwaukee's version of "Bloody Sunday" serves as the opening for Patrick Jones' book The Selma of the North, which examines Civil Rights and Black Power activism in Milwaukee in the 1950s and 1960s. Although the confrontations in Selma and Milwaukee were strikingly similar, they were also starkly different. Among other things, in Milwaukee, public officials ordered the police to protect the demonstrators; whereas in Selma, Governor George Wallace


This paper deals with an application of advanced simulation methods to the modelling of Duel-Fuelled engines (Hydrogen/Diesel) in which the premixed Hydrogen gas is ignited by the combustion flame initiated by a diesel spray. The model consists of a diesel auto-ignition model and a modified combustion model. The influence of main engine parameters i.e., injection advance, and various percentages of mixing of hydrogen with diesel on rate of heat release, flame propagation and NOx formation has been investigated. Experimental results were compared with modelled values. Computational Fluid Dynamics (CFD) analysis was carried out and limitations of the model were studied.


This article provides a specific case of how changes across the international division of labour have impacted upon — and been contested by — the workers involved in commodity production. Cantin employs a long-term perspective, detailing the establishment of garment production in the US as a sweated industry in the early 1900s and the movements that were frequently successful at raising conditions across the industry in the subsequent decades. He then focuses on the ways in which various worker movements have challenged the effects of the deepening transnationalisation of garment production since the 1960s on their employment and working conditions. While the US garment industry has undergone a significant dissolution of jobs and a lowering of pay and conditions, Cantin examines how the experience of previous defeats inflicted on worker movements has led to a greater acknowledgement of workers of the necessity to mobilise on an international basis to complement and strengthen local forms of organisation. He suggests that these lessons are starting to lead to cautious yet important attempts to change the strategies pursued by organised labour in the North American garment industry.


An apparatus includes a closed body with a varying configuration between a first location and at least a second location. The apparatus further includes a pressure sensor that is coupled to the first location on the closed body. When forces are applied having substantially the same sizes, each at different locations between the first and the second location on the closed body, the closed body translates the respective forces in substantially the same pressure differentials at the first location.


To the Editor, We present an unusual case of an unexpected pulse granuloma in the distal ureter which was a mimic for malignancy. A 66‐year‐old man, with a past medical history of hypertension, underwent a cystoprostatectomy with ileal conduit for recurrent bladder urothelial carcinoma. One month after surgery, the patient developed flank pain, worsening kidney dysfunction and bacterial urinary tract infection. Work up including imaging revealed left hydronephrosis secondary to a presumed left ureteroenteric anastomotic stricture. In addition to antibiotics, a left percutaneous nephrostomy tube placement was performed. The patient elected conservative management with urinary diversion. A follow‐up computed tomography urogram performed 4 months later showed persistent hydronephrosis of the left kidney with hydroureter secondary to a mass at the distal end of the left ureter (Figure 1a). The patient subsequently consented to undergo a left ureterectomy with ureteral reimplantation to treat the stricture and to rule out malignancy. Grossly, the distal ureter mass was a 1.3 × 1.0 × 0.9 cm, tan‐pink fibrotic soft tissue. Microscopic examination revealed relatively well circumscribed, easily identifiable eosinophilic foreign material deposits with associated foreign body giant cell reactions and fibrosis in the thickened ureteral wall (Figure 1b) and the mass lesion (Figure 1c,d). These pink hyaline rings and ribbons of foreign material were positive for periodic acid‐Schiff and stained pale green on Masson trichrome (Figure 1e,f), whereas they were negative for Elastica van Gieson and Congo red stains (data not shown). No malignancy was identified in the specimen. In botany, a pulse is defined as the edible seeds of various crops (such as peas, beans, or lentils) of the legume family. Pulse granuloma or hyaline ring granuloma is a rare granulomatous reaction process that most commonly occurs in the oral cavity, gastrointestinal (GI) tract, and less frequently the respiratory system. GI tract involvement has been reported in the small intestine, colon, appendix, liver, gallbladder and mesentery. Most of these cases presented with a history of mucosal injury caused by diseases including diverticulitis, fistula, perforation, ulcerative colitis, anastomotic site leak or even adenocarcinoma. To the best of our knowledge, only one prior case report of a pulse granuloma in the urinary tract (bladder) has been published. The dense pink material in a pulse granuloma has typically been regarded as a hyalinizing vasculopathy; however, recent studies have demonstrated this is not the case. Pulse granuloma is induced by the cellulose cell wall of storage cells that are derived from ingested seeds of leguminous and non‐leguminous plants. The plant storage cell acts as a nutrient reservoir containing starch, protein and lipid. Histologically, three morphologic variants of pulse granuloma have been reported: the hyaline predominant type which can mimic amyloid deposit, the cellular predominant type which resembles spindle cell neoplasms, and the sclerosing mesenteritis‐like type. Pulse granuloma in the GI tract sometimes presents as a mass lesion that can raise clinical and radiographic concern for malignancy. In our case, the patient presented with flank pain, hydronephrosis and hydroureter secondary to ureteral stenosis and a worrisome mass lesion identified on imaging. Given the patient's history of urothelial carcinoma, these findings were concerning as a possible cancer recurrence, thereby another ureterectomy was performed. While the etiology for this case is not clear cut, given the presence of an ileal conduit and the mechanism behind pulse granuloma formation, it is plausible that this was due to exposure of cellulose cell wall material from the nearby ileal conduit. This is the second case of a pulse granuloma within the urinary system and the first case within the ureter.


We present a state-of-the-art two-dimensional (2-D) device simulator suitable for highly doped n-MOSFETs. Quantization effects in the inversion channel are accounted for by a self-consistent solution of the Poisson, current-continuity and Schrodinger equations. The electron charge is given by a density of electrons in the bounded levels plus a density of classically-distributed carriers. Consequently, different mobility models are used. For the former, we adopted a nonlocal, newly-developed mobility model, thus overcoming the deficiency of currently-used mobility models in the high-doping limit. We instead retained a standard local model for the classical regime. Results of the simulations are in good agreement with the experiments.


Node.js is good, very good. That at least is what Node Foundation, the maintainer of Node.js, wants to convey. But is that the truth? This report tries to answer the question if Node.js can live up ...


This study applied a shared heterogeneity duration model to tourists' length of stay at different locations of multidestination trips. This analysis helps to understand tourists' behaviors and to predict their length of stay according to relevant variables. Such information can be applied to the development of efficient marketing strategies aiming to push the average length of stay to the desired direction, and to develop "on the fly" service provision and revenue management strategies. The focus on multiple destination trips offers an innovative analytical perspective. A large data set of 309,000 visits to Brazilian destinations was analyzed. Several empirical findings regarding determinants of tourists' length of stay were obtained. Positively skewed distributions for duration and hazard functions were found to best fit observed data. Shared heterogeneity was found to statistically improve the explanatory capacity of duration models when multidestination tourism trips data are analyzed.


Internet is changing the way consumers shop and buy goods and services. The initial success stories of online shopping have forced the marketers to incorporate the use of internet based technology for promotion and selling of their products and services. On the other hand customers find web retailing as an easy convenient platform not only for ordering the product online, but also to compare prices, product features and after sale service facilities provided by competitive marketers before making such buying decisions. This paper integrates two important streams of literature of the theory of reasoned action (TRA) and the technology acceptance model (TAM) with Buyers behaviour items and has explored the useful dimensions of ebuying behavior for web retailing. The study also revealed that the extracted factors of ebuying behavior for web retailing namely Delighted buyers, Information Seeker and Skeptical buyers have shown similar influence on different age group of respondents.


In figure 1 we see a general schematic of one of the comparator circuits which were built. The voltages to be compared are fed through one megohm resistors (or, since the grid is also available, other resistances may be used) to the grid of a one-tube operational amplifier. This amplifier operates open loop, giving a measured switching sensitivity of about 100.0 millivolts input differential. The circuit of the


While Extension communication units have seen success in implementing brand strategies to raise awareness of Extension, the public value and need for Extension programming continue to be misunderstood. College students have the potential to ensure the future of Extension is viable. To expose undergraduate students to the brand and value of Extension, a public relations seminar was developed and delivered by a state Extension specialist to 95 students enrolled in an agricultural technical writing course at a land-grant university. The seminar served as a treatment in the quasi-experimental design, which included information about the land-grant mission, Extension resources, and potential careers related to Extension. Findings revealed that the public relations seminar had a significant impact on the students' awareness and value of Extension and their consideration of Extension as a career. Implications from this study support strategic public relations having a positive, short-term impact on students' perceptions of Extension. While future research should explore the long-term impacts of public relations on students' perceptions of Extension, it is recommended that Extension professionals and agricultural communicators implement public relations activities targeting undergraduate students and use brand advocates, like Extension specialists, to elevate the brand.


This paper investigates the effects of fiscal deficit on the external sector of Sierra Leone. The study utilized aggregate annual data from 1971 to 2005. Equations for money supply, price level, real exchange rate and the overall balance of payments were estimated simultaneously, using Three Stage Least Squares (3SLS). Counterfactual policy simulation was then performed. The result shows that fiscal restraint improves the external sector of Sierra Leone by reducing money supply and the price level. The result also points to the need for a sustained reduction in the budget deficit of Sierra Leone as this helps in achieving monetary restraint and low price level, which has real exchange rate depreciation and improvement in the balance of payments as ultimate external sector benefits. This requires sound fiscal policy from the point of view of both revenue generation and expenditure. JEL Classification Codes: E62, F41, F47.


Aiming at the oil-well logging device, this paper is working on power supply modes for its driving hydraulic pump motor, and here it has compared and analysed advantages and disadvantages of seven power supply modes, then put forward a most promosing motor power supply mode. This mode has overcome disadvantages existed in traditional oil-well logging power supply method, i.e. , the transitional "voltage regulator along with transformer" method, and provided advantages of small volume,light weight, convenient voltage regulation, small starting voltage, fast transient response, and high intelligence degree. Thispower supply is composed of several IGBT power transforming units, and has realized the transformation from single-phase low voltage of AC110V to dual-phase middle voltage of AC600 ~ AC1200V after multiple AC/DC/AC-AC/DC/AC voltage transform links. To this power supply device,the design scheme is new, and the technology is advanced, and the performance index is superior. Therefore, it can be spreaded and applied in the field of oil-well logging.


In the discussions published in the Phuket Papers relative to the health responses following the earthquake and tsunami of 26 December 2004, two important issues were raised. The first issue was, "Why have we not learned from what we have learned?" The second issues discussed in each of the Phuket papers addressed: "What went well?"; and "What could have been done better?" These issues stimulated much discussion and highlighted the needs for the evaluation and reporting of the impact(s) of the events and of the interventions provided prior to (preparedness and risk reduction) and following the events (relief and recovery responses). During my presentation at a national conference, I expressed concern about the processes used for planning, implementing, and evaluating interventions directed toward enhancing preparedness. During his summary of the proceedings of the conference, a noted colleague expounded that we only need to know the outcomes of interventions, and that the processes involved in the intervention were not important. It is this assertion, and the underlying attitude, that epitomize our failure to learn from what we have learned.


Experimental researches of infl uencing concentration molecules of stearin acid on the properties of working liquid taking into account treatment by its electric fi eld are conducted. Rational concentration, at which a minimum wear of pairs of friction is is defi nite. A method is developed rise of resource of the hydraulic systems facilities of transport by treatment of working liquid by the electric fi eld.


The fortunes of federally chartered biomedical ethics advisory bodies are looking up. After nearly a decade when bioethics committees were either kept in suspended animation or allowed to function but given no authority, there are clear signs in Washington that 1993 will see one or more bioethics committees formed with significant power to shape public policy. Two factors are responsible for the sea change. First, in the waning years of the Bush administration there was growing frustration in Congress with White House willingness to give in to demands from the ultra-right wing of the Republican Party. The resentment began early in the Bush years. A pro-life "litmus test" for the traditionally nonpartisan post of director of the National Institutes of Health (NIH) sent a clear message. The point was driven home for many in Congress when the administration ignored its own advisory committee's recommendation and extended a moratorium on funding for fetal tissue transplant research. Several committees in both the House of Representatives and the Senate began drafting legislation that would create ethical oversight committees to protect sensitive research. The idea was to separate true ethical conundrums from political expediency. The second factor promising change is, of course, the electron of Bill Clinton. Within days of the election, career federal bureaucrats whose political sympathies were never in line with the Bush administration began making plans to undo some of the conservative agenda enacted by executive fiat. Within days of his inauguration, Clinton signed orders overturning the moratorium on federal funding for research on transplantation using fetal tissue from induced abortions, reversing the gag order that prohibits doctors in federally funded clinics from discussing abortion as a birth control option, and permitting foreign aid to nongovernmental family planning organizations that offer abortion services. It will take some negotiating between Congress and the new administration to decide how these changes should best be implemented. Last year, both houses of Congress passed the NIH reauthorization bill that would have created a watchdog ethics advisory board in the Department of Health and Human Services. According to the bill's language, the secretary of the department would be obliged to convene the ethics board if he or she intended to veto spending for a scientific project that had already been approved for funding by a peer review panel. If the board determined that the research was ethically justified, the secretary would have to release the funds for the project. …


: The main purpose of this research project is to simulate and display the traditional costumes of the Gaoshan people in Taiwan from the perspective of design by the use of 3D scanning and virtual modeling technology, and to analyze the important design techniques and visual features that influence the public perception of the traditional clothing of the Gaoshan people.Firstly, six typical sets of Taiwan's Gaoshan traditional costumes were selected. Then, the model with high degree of reduction was generated by 3D scanning. Secondly, a MAYA modeling software was applied to build a clothing model and optimize the texture so that the virtual simulation of clothing model can be preserved based on the 3D design software. In the display system, Unity3D was used as a production platform to create the virtual display scene of the clothing museum. Finally, it took the Unity3D as an engine to build a virtual museum display system platform for presenting the Taiwan's Gaoshan traditional clothing.The research has realized the systematic display of the traditional costumes of the Gaoshan people, broken through the limitations of the realistic display, and pushed forward the display of traditional costumes to be terminalized, mobile and convenient. And the further ergonomics research can also be carried out on the platform.The abstract should summarize the contents of the paper and should contain at least 70 and at most 200 words. It should be set in 9-point font size, justified and should have a hanging indent of 2-centimenter. There should be a space before of 12-point and after of 30-point.


DNA data storage has become one of the most high-profile techniques for long-term data storage. In the process of synthesizing, storing, amplifying, and sequencing of DNA sequences, there are constraints on the form of the DNA sequences, namely repeated bases avoidance, proper GC content, and special DNA fragments avoidance. Previous studies met the constraints either at the cost of information density or too complicated for implementation. In this paper, we propose an encoding method called MRC (Mixed Radix Coding) that can effectively satisfy those constraints and achieve the almost theoretically optimal information density as well. MRC is very easy to implement in practice and extend to accomodate other DNA coding constraints.


estimating its pose, we present it as a particle filter based probabilistic method with information of a sequence of images. It means that object pose represents probability distribution by particles in 3D space, and updated particles by consecutive observation in a sequence of images are converged to a single particle. The proposed method allows an easy integration of multiple evidences such photometric and geometric features as SIFT, color, 3D line, 2D square, and etc. The experimental results with stereo camera show the validity of the proposed method in an environment containing both textured and texture-less objects.


4568 Background: Device-assisted intravesical mitomycin-C (MMC), including electromotive administration (EMDA) and thermochemotherapy (TC), shows promise and offers the prospect of greater efficacy...


FERRY ANGGRIYANI. Relationship Between the independence of Students Career Guidance In Choosing Career In Class XII Students of SMK N 48 Jakarta. Scription, Jakarta: Study of Commerce Education. Major Economy and Administration, Faculty of Economy, State University of Jakarta.
The study was conducted over four months from March to July 2012. The method used is the method of survey correlation approach. The population in this study were all students of class XII SMK N 48 Jakarta. Inaccessibility population is XII class student Marketing majors who are 71 students. Then, based on the sampling table of Isaac and Michael number of samples from a population with a sampling error of 5% is 58 students. This sampling technique using simple random sampling technique.
To capture the data variable X (Career Guidance), used questionnaires shaped instrument, which is distributed to the students of class XII of Marketing, after it tested the validity of the contents through the validation process of calculating the correlation coefficient score points with the total score and the reliability test by Cronbach alpha formula. Then for a variable Y (Independence Students In choosing careers) shaped instrument also used a questionnaire, distributed to students of class XII Marketing. Results of reliability variable X (Career Guidance) of 1028. While the reliability of the outcome variable Y (Independence In Choosing a Career) by 1034.
Test requirements analysis is done by looking at the regression equation is Y = 73.27 to 0.225 x X. Next is the estimated regression error normality test on X using the test and obtained Liliefors Lo = 0.085 compared with Ltable in 0.116 at the 0.05 level. the Lo  F table (4.02), this proves that the regression mean. While the linearity test result Fcount (8.64) t table. The calculation of the coefficient of determination produce rxy2 = 0.5672 = 0.3211. This shows that 32.11% variation independence of students in choosing a career is determined by the career guidance. The conclusion of this study is that there is a positive relationship between career guidance to students in choosing a career independence in class XII SMK N 48 Jakarta.


In this paper propagation of soft-output information through the Boolean logic circuits is considered. As the result, an implementation of log-likelihood ratio (LLR) algebra in Boolean logic mappings is presented. The consequence of this approach to the soft-output decoding of maximum transition run (MTR) codes and their utilization in iterative decoding has been simulated and evaluated over E2PR4 magnetic recording channel


This thesis seeks to contribute an analysis of the historical events that led to economic growth and development of Walla Walla, Washington, from the early 1800s to 1900. Various factors helped Walla Walla become established as an influential city in the Pacific Northwest. In this thesis, three major events that guided Walla Walla were studied. The first of these events came from the military influence of Fort Walla Walla, which helped set the foundations for the future city. The second event was the mining rushes through Washington, Idaho, and western Montana. Walla Walla stood as a key trading center for the region during the first two periods. In the late 1800s, Walla Walla experienced the last major event, the coming of the railroads to the Pacific Northwest. The railroads would change the course of Walla Walla"s fate as it entered the twentieth century. This thesis explores the influence Walla Walla had on the Pacific Northwest as the area grew from unorganized lands to territories and finally into the states of today. It also examines the city"s economic growth through each of the three events as it developed from a tent village into a recognized and historically significant city.


The process of crystallization and the characteristics of crystalline poly-3,3-bis(chloromethyl)oxacyclobutane were investigated by infrared spectroscopy. A comparison of the spectra obtained when the electric vector was vibrating parallel to and perpendicular to the extended direction of specimens of this polymer showed significant dichroism in the majority of absorption bands; also, intensity changes as crystallization of the polymer proceeded were observed in both types of spectra. The crystallization process was examined by noting changes in the spectra with increase in the temperature of the polymer; many crystallization-sensitive bands were found. The dichroism was particularly marked in the absorption bands which may be due to the wagging-mode, twisting-mode, and rocking-mode vibrations of the methylene groups in this polymer. Optical densities of the bands a t 1027 cm−1, an amorphous band, and 897 cm−1, a crystalline band, were observed a t various temperatures during cooling of the polymer. By use of a plot of the optical densities of both bands against the temperature of the polymer, the degree of crystallinity of the polymer could be estimated as a function of the polymer temperature. The results are in good agreement with the dilatometric results for the crystallization rate. Also, the polymorphism of the polymer, which had been detected by x-ray analysis, was investigated by the use of infrared spectroanalysis. On the basis of deductions derived from these experimental results, we hypothesized a macromolecular structure for this polyether.


ABSTRACT. Continuous measurements of respiratory water loss (RWL), oxygen consumption and carbon dioxide production were made in 21 fullterm infants on their first day after birth. The infants were first studied in incubators with a temperature of 32.5°C and an ambient humidity of 50%. After an interval with stable conditions the incubator temperature was raised to 36.5°C while the water vapour pressure was kept constant. When the rectal temperature had increased to 37.8°C or when the infant had started to sweat, the relative humidity in the incubator was increased to 50%. At the start of the measurements mean RWL was 4.9 mg/kg min. On the average, RWL increased to a maximal value of 7.0 mg/kg min in the warm environment. Mean oxygen consumption only increased from 5.3 to 5.8 ml/kg min. This meant that when nursed in this warm environment the infants were able to increase their respiratory water loss by nearly 50% without a significant change in oxygen consumption.


Abstract:This article considers how meantone temperament relates to two important contrapuntal techniques in the early Baroque: stretto fuga and sequence. I focus on ensemble works intended for keyboard accompaniment by Claudio Monteverdi and his contemporaries, Giovanni Rovetta and Chiara Margarita Cozzolani. As early as 1609, the organist-composer Adriano Banchieri expresses how an ensemble should be tuned to match the meantone keyboard. I show how this practice required composers to adhere to two meantone limitations that I describe in the first part of the study: (1) the meantone gamut and (2) Banchieri's "rule of strict counterpoint." Despite the name of Banchieri's rule, I explain how the rule actually pertains to meantone temperament. The second part of the study considers the contrapuntal ramifications of these two meantone limitations. I account for two- and three-part stretto fuga and the most common sequences in the early Baroque. I illustrate how accidentals, contrapuntal adjustments, transposition intervals, and even the overall length of passages all relate to the two meantone limitations. Accounting for the relationship between temperament and counterpoint unveils a hidden force governing contrapuntal choices in the early Baroque and provides analysts with a new method for approaching this repertoire.


Abstract. This study aims to describe the effectiveness of 4c skill-based LKPD on the Research Based Learning model for physics learning for high school students. The research method used is a research and development method by using the Plomp development model, namely Preliminary Research¸Prototype Phase and Assessment Phase . The instrument used was the LKPD effectiveness sheet seen from the 4c Skill of students. The results of the study indicate the value of an increase in analysis that LKPD through the Research Based Learning model is effective in efforts to improve the 4C skills of education participants. Keywords. LKPD, Research Based Learning, 4C Skills Keywords. LKPD, Research Based Learning, 4C Skills


Given the scalability and vast applicability of the heterogeneous catalysts and the burgeoning interests in biorelated applications, the interpenetrating polymer network catalysts will facilitate the realization of green, precise and efficient polymerization.


We generalize the formalism proposed by Dalibard, Dupont-Roc, and Cohen-Tannoudji (the DDC formalism) in the fourth order for two atoms in interaction with scalar fields in vacuum to a thermal bath at finite temperature T, and then calculate the interatomic interaction energy of two ground-state atoms separately in terms of the contributions of thermal fluctuations and the radiation reaction of the atoms and analyze in detail the thermal corrections to the van der Waals and Casimir–Polder interactions. We discover a particular region, i.e. λ3β4≪L≪λ with L, β and λ denoting the interatomic separation, the wavelength of thermal photons and the transition wavelength of the atoms respectively, where the thermal corrections remarkably render the van der Waals force, which is usually attractive, repulsive, leading to an interesting crossover phenomenon of the interatomic interaction from attractive to repulsive as the temperature increases. We also find that the thermal corrections cause significant changes to the Casimir–Polder force when the temperature is sufficiently high, resulting in an attractive force proportional to TL −3 in the λ ≪ β ≪ L region, and a force that can be either attractive or repulsive and even vanishing in the β ≪ λ ≪ L region depending on the interatomic separation.


Development of new reservoirs are utmost important for their utilization of providing water for irrigation, hydropower and flood damages reduction etc. In-addition to constructing new reservoirs, the efficient and sustainable use of existing reservoirs is also important for rapid economic growth of world. Pakistan is blessed with rich surface water resources of 180 Billion m3 annualy. However, total storage capacity of the three large dams is 17 Billion m3 which is only 10% of the available water resources. The current study identifies the latest trends for optimizing the utilization of water from reservoir to agriculture farm and their possible application to Pakistan. The paper also investigates the potential of inflatable dams in Pakistan for recharging of groundwater, as diversion weir for small hydropower plants, water supply and creating artificial lakes for recreation purposes. On the basis of criteria developed in the study, 31 sites were selected for checking their feasibility. SRTM 90m digital elevation database and Google Mapper were used to develop digital elevation models and contours for studying different technical parameters. Total 27 sites were found feasible and indicated the potential for Inflatable Dams in Pakistan on the basis of preliminary results. For sustainable and optimized utilization of water resources, it is utmost important to implement the following measures identified for supplying water from reservoir to crop root zone are: remodeling/ modernization of barrages and canals including lining of distributaries and minors. Adoption of resource conservation technologies, and optimized cropping systems by including high value and high yield crops are recommended in the study for achieving the desired objectives.


With regard to mental capacity and psychiatric admission,1 2 we carried out a trustwide audit into mental capacity assessment and documentation in North East London Mental Health Trust in September-November 2007, the Mental Capacity Act 2005 having been implemented in April 2007. The standard used for the audit was that the mental …


The connection between land use and transport has been known for centuries: the link is acknowledged in the literature and the results are visible from space (as a visit to Google Earth will confirm). Integration has been urged on planning and transport practitioners by governments for many decades, but the extent of integration actually achieved has been modest. Why? This Viewpoint is an attempt by a practitioner with some 35 years at the urban coal face of this issue to offer, if not an answer, at least a perspective on the question. Land use and transport: a historical perspective Peter Hall (1994) has reviewed a classic paper by Colin Clark (1957) (originally published in this journal) on the symbiosis of cities and their transport systems over the last 200 years, and his analysis provides the framework for this Viewpoint. Figure 1 summarises the thesis: that while earlier urban crises have been resolved by new transport technologies, the urban crisis produced by road dominance remains unresolved. In spite of the scale, longevity and significance of this connection between transport and land use, it has played almost no part in the evaluation of transport investments since 1945 (Wenban-Smith, 1999). The conventional justification of this extraordinary state of affairs is that (with perfect competition) these broader, indirect and longer-term effects will be equal in value to the initial traveller benefits, however long and tortuous the intervening chain of causation.1 This is very convenient for transport planners as estimates of time savings are a by-product of modelling for scheme design, and for the Transport Department because it keeps the whole business of justification in-house. By the mid-1980s, in conformity with this doctrine, around 80 per cent of the benefits arising from road investment were recorded in Transport Department annual reports to Parliament as taking the form of user time savings. Although a wider range of factors now appear to play a part in evaluation,2 time savings remain the bedrock of quantified benefits of roads and so dominate cost-benefit analyses. Recently there has been an interesting shift in this position: the Barker (2006) and Eddington (2006) reports identify the effect of transport on urban productivity as being a potential benefit, quite distinct from user time savings. Agglomeration - the benefit to productivity arising from the concentration of economic activity in urban areas - is arguably related to the longer-term, indirect effects noted by Clark and Hall. Barker sees this as a further reason to remove planning constraints to development around the edges of existing urban areas, while Eddington sees it as a reason to prioritise those urban transport schemes which are most effective in tackling urban congestion. I would argue that both these responses are misguided: because of unintended side effects, they will not only fail in their primary (economic) intentions, but will deliver worsening housing and transport outcomes too. This is because the Barker and Eddington formulas reinforce the effects rather than address the causes of the urban crisis brought about by road dominance. Housing and transport The Barker Report gave birth to the Housing Green Paper (DCLG, 2007), now being enthusiastically implemented by the Government. Figure 2 puts the Green Paper targets for new housing in the context of performance since 1945. From this it can be seen that although high, the growth numbers are not unprecedented. However, the private sector has not consistently sustained such levels of output in the past, and higher totals have depended primarily upon higher provision of social housing. Unlike some of the rhetoric that preceded it, the 2007 Green Paper effectively accepts that building more houses for owner-occupation will make very little difference to affordability, and recognises the key role of more social housing. …


analysis nearly all of the rich symbolic stuff in Hawthorne is explainable in terms of an unresolved Oedipus complex that genetically-given catchall to which orthodoxy relegates by fiat the whole enormous population of neurotics. The surmise that the terminus of each elegant dissection, as well as the finale of the whole inquiry, was preordained from the beginning by the analyst's overconfident attachment to this single formula is supported by the demonstrable fact that Professor Crews has overlooked so much so much that stems from a reversal of mother love, so much that is more prevalent and potent than parricide, so much, in short, that is essential to any complex "figure in the carpet," that could deservedly be accepted as Hawthorne's distinctive signature.


OBJECTIVE
To evaluate the safety of repeated applications of permethrin concentrations (0% control, 1.5%, 5%, and 10%) to the necks and faces of horses and assess the efficacy and longevity of permethrin as an equine tick repellent.

ANIMALS
5 healthy adult Quarter Horses.

PROCEDURES
Each treatment was applied to the neck of each horse (0.01 m2) 4 times a day, for up to 10 days. An 8-mm biopsy was taken to evaluate postexposure dermal responses. Any treatments that were not withdrawn were applied to a quadrant of the horse's face 4 times a day, for up to 5 days. For tick bioassays, a treatment was applied to 1 leg of a horse and 5 female blacklegged ticks (Ixodes scapularis) were evaluated as "repelled" or "not repelled" by the treatment. The bioassays were repeated up to 5 days, but treatment application took place only on the first day of the experiment.

RESULTS
Histological results of neck biopsies indicated that more repeated exposures or higher concentrations resulted in more dermal damage. Tick bioassays showed that 5% and 10% permethrin had the greatest efficacy and longevity as a tick repellent, but the differences in tick repellency were not significant overall.

CLINICAL RELEVANCE
While there was a nonsignificant trend of higher permethrin concentrations repelling more ticks with longer-lasting residual repellent effects, higher concentrations also produced greater skin damage after repeated exposures. These opposing findings emphasize the need for better tick prevention and control methods that balance safety and efficacy for the equine community.


Foursquare interim president Glenn C. Burris Jr. was selected as the church's new president by leaders attending Foursquare's annual Connection convention in Atlanta.


We address the problem of computing integrated mean-squared error (IMSE) optimal designs for interpolation of random fields with known mean and covariance. We assume that the mean squared error is integrated through a discrete measure and restrict the design space to its support. We show that the IMSE and its approximation by spectral truncation can be easily evaluated, which makes their global minimization affordable. Numerical experiments are carried out that illustrate the effectiveness of the approach.


The formation and consumption of CH radicals during shock-induced pyrolysis of a few ppm ethane diluted in argon was measured by a ring-dye laser spectrometer. Absorption-over-time profiles, measured at a resonance line in the Q-branch of the A2Δ − X2Π band of CH at λ = 431.1311 nm, were recorded and transformed into CH concentrations by known absorption coefficients. By adding some hundred ppm of CO2 or O2 to the initial mixtures, the CH concentration profiles were significantly perturbed. Both the perturbed and unperturbed CH concentration profiles have been compared with calculations based on a reaction kinetic model. A sensitivity analysis revealed that the perturbation process was dominated by direct reactions of CH with the added molecules. By fitting calculated to observed CH profiles the following rate coefficients were obtained

The experiments were performed in the temperature range between 2500 K and 3500 K. © 1996 John Wiley & Sons, Inc.


This paper briefly reviews one model of the total NPD process, viewed as a "strategic business process". The model is based upon that used by the UK Time to Market Association, and its member companies, and put forward as being, for many NPD situations, a "best practice" model. The most successful implementation of the model usually requires good "change management" within companies and also demands particular attention to the avoidance of some potential management shortfalls that are liable to occur. These have been noted to be prevalent for various ways of organizing NPD activity so that a consideration of them should be generally useful to all companies engaged in NPD. This paper reviews these typical management shortfalls. They have been observed from practical experience as well as from the case studies. These typical shortfalls relate to the performance of the senior people who oversee the NPD work, poor project review process, under-qualification of project team leaders, insufficient manufacturing inputs, and unrealistic planning. Whether or not these shortfalls are universally the "most frequent" and the "most important", is arguable. What is clear from practical experience and some case studies, is that they are certainly very frequent and very important-because their effects can be devastating to the NPD effort. The authors discuss the "root causes", and suggest ways to avoid and remedy them.


The considerable morbidity and mortality associated with lower respiratory tract infections makes it essential that patients receive optimal clinical management and antibiotic therapy. Treatment guidelines provide physicians with a consensus-and/or evidence-based framework for effective therapy and can promote responsible antibiotic use. In the case of community-acquired pneumonia, several guidelines have been published in recent years. Recommendations for empiric therapy are based on the need for early intervention, the optimal site of patient care, and the presence of risk factors for antibiotic-resistant pathogens. Therapy options are dominated by the use of β-lactams, macrolides, doxycyline and newer fluoroquinolones, used either singly or in combination. By contrast, only one set of guidelines for hospital-acquired pneumonia has been published. In this case, the choice of initial empiric therapy is based on the severity of illness, the presence of risk factors for resistant pathogens, and the time of onset relative to hospitalization. The use of agents with activity against Pseudomonas and methicillin-resistant Staphylococcus species is indicated in selected patient groups. European treatment guidelines for patients with acute exacerbations of chronic bronchitis support the use of antibiotic therapy in patients with Anthonisen type I exacerbations. β-Lactam agents, new macrolides, and fluoroquinolones are included as recommended therapy options. The consideration of local etiologies, antibiotic resistance patterns, and healthcare practices is vital to the effective implementation of treatment guidelines.


It is a well known fact that endocrine glands release all produced hormones directly into the venous blood, which immediately, via pulmonary circulation, is delivered to the lungs that have an enormous surface area. We postulated that lungs might exert an important influence on the entire physiological spectrum of all hormones being transferred through them. The results of our experimental and clinical studies of the levels of hormones in afferent (venous) and efferent (arterial) pulmonary blood flow revealed previously unknown or unnoticed phenomena that lung tissue participate in qualitative and quantitative state of all studied hormones (ACTH, aldosterone, cortisol, angiotensin‐II, insulin, glucagons, thyrotropic hormone, thyroxin, triiodothyronine, vasopressin, rennin) in general arterial blood flow in humans and experimental animals. We have also proved that central neurogenic regulation of transit, storage or release of above mentioned hormones into arterial blood is greatly influenced by physiological status of hypothalamic structures. Thus, the system of entire hormonal homeostasis is added by important and mandatory physiological unit ¨C the lungs. In our opinion this system should be viewed as: HORMONES ¡ú VENOUS CIRCULATION ¡ú LUNGS ¡ú ARTERIAL CIRCULATION ¡ú TARGET TISSUES.


Measurements of the cosmic ray p/p ratio are compared to predictions from an inhomogeneous leaky box model of Galactic secondary p production combined with an updated heliospheric model that modulates the predicted fluxes measured at the Earth. The heliospheric corrections are crucial for understanding the low–energy part of the spectrum. The p production-propagation-modulation model agrees with observations. Adding a finite p lifetime to the model, we obtain the limit τp > 1.7 Myr (90% C.L.). Restrictions on heliospheric properties and the cutoff of low-energy interstellar cosmic rays are discussed.


Vitamin C values for 37 traditional foods (TFs) of the Inuit of the Canadian Arctic and women's intakes from TF and market food (MF) are reported. This is the first report on vitamin C values in several traditional food samples. There are a variety of rich sources of vitamin C from animal and plant food with the most notable among items with multiple samples being raw fish (Coregonus spp.) eggs (49.6712.3 mg/ 100 g, mean7S.D.), raw whale (Delphinapterus leucas and Monodon monoceros) skin, locally termed ''mattak'', (36.078.7 and 31.577.0 mg/10 g), caribou liver (Rangifer tarandus) (23.874.9 mg/100 g), ringed seal liver (Phoca hispida) (23.873.8 mg/100 g), and blueberries (Vaccinium uliginosum) (26.274.9 mg/100 g). Dietary analysis of 20–40-year-old women's 24-h recalls for vitamin C as TF and MF revealed total mean intake of60 78 mg/day (mean7S.E.). TF contributed only 20% oftotal intake, although there was significant seasonal variation (Po0.02). While rich sources of vitamin C are present as TF, the primary contemporary dietary sources ofthis nutrient are fortified MF. r 2002 Published by Elsevier Science Ltd.


Using.NET controls technology and C# program language,this paper designs and achieves a virtual experiment system of network server based on B/S mode.Students don't need to enter the real lab.,they can finish the online autonomous server configuration experiments only through the Web browser.This paper introduces the design and application process of the virtual experiment system.


The stress corrosion cracking behavior of friction stir processed, micro arc oxidation coated and a composite coated (friction stir processed-micro arc oxidation) ZE41 magnesium alloy were studied in modified simulated body fluid (m-SBF) solution at room temperature. Friction stir processing was carried out with a tool rotation speed of 650 rpm and a traverse speed of 50 mm/min. The results showed that fine equi-axed grain structure with an average grain size of ∼2.8 µm, fragmentation, and partial dissolution of T-phase and Zr-rich particles was achieved through friction stir processing. Specially designed two electrode coating method was adopted to produce samples with micro arc oxidation coating in silicate solution. The stress corrosion cracking susceptibility of base metal, friction stir processed, micro arc oxidation, and composite coated friction stir processed-micro arc oxidation samples were evaluated through constant load testing at five different stress levels. The results indicated higher stress corrosion cracking susceptibility for base metal compared to friction stir processed; micro arc oxidation and friction stir processed-micro arc oxidation samples. Grain refinement and microstructure homogenization enhanced stress corrosion cracking resistance of friction stir processed sample whereas the barrier effect of coating during initial stages of corrosion improved stress corrosion cracking resistance of micro arc oxidation sample compared to base metal. Among all the samples, friction stir processed-micro arc oxidation exhibited superior stress corrosion cracking resistance due to the self-repairing mechanism of friction stir processing, which in turn improved the corrosion resistance of micro arc oxidation layer. The fractographic features revealed different stress corrosion cracking mechanisms for base metal, friction stir processed, micro arc oxidation, and friction stir processed-micro arc oxidation samples. T-phase and Zr-rich particles played major role in the initiation of corrosion pits and resulted in stress corrosion cracks.


The study aims to know about the effect between before and after taught using the Instagram feed. This study used pre-experimental with non-parametric. The researcher used one-group pre-test and post-test design. In this research, the population consists of grade tenth SMK Sore Tulungagung and 15 students in one class for the sample. The researcher used Cluster Sampling. The instruments used in this study were tests and Instagram feed. The analysis of the data obtained using Saphiro Wilk, Levene Test, and Wilcoxon Test in SPSS 21.0.  The finding of this research showed that the pre-test standard error mean is 0,235 < 5,40, and the post-test standard error mean is 0,133 < 8,47. The Asymp. Sig was 0,001, it was smaller than 0,05 (0,001 < 0,05). It can be concluded that the hypothesis is accepted. This means that there was a difference between the results of learning descriptive text writing for pre-test and post-test. Overall, it might be concluded that using Instagram as a teaching tool for writing the descriptive text was a good idea. Teaching writing descriptive text using Instagram Feed was effective for students at tenth-grade SMK Sore Tulungagung for the 2020/2021 academic year


Three rice harvesting systems namely: traditional harvesting, partial mechanization and full mechanization were deduced and compared. Experiments were carried out in rice fields to determine total grain losses, energy consumed and total cost requirements for harvesting rice crop. The results indicated that, in partial mechanization, the minimum total grain losses of 4.73 % resulted from machine forward speed of 2.1 km/h and higher grain moisture content of 25.91%. While in full mechanization, the minimum total grain losses of 1.84 % resulted from lower forward speed of 1.6 km/h and grain moisture content of 21.85 % compared with traditional harvesting system, which recorded about 3.64 %. In both partial and full mechanization, the minimum energy consumed of 44.91 and 40.62 kW.h/fed resulted from higher machine forward speed of 3.1 and 2.8 km/h at lower grain moisture content of 19.64%. Compared with traditional harvesting which consumed about 45.00 kW.h/fed. at lower grain moisture content of 19.64 %. Results indicated in both partial and full mechanization, the minimum cost requirements of 227.83 and 140.91 L.E/fed resulted from higher machine forward speed of 3.1 and 2.8 km/h and lower grain moisture content of 19.64 %. Compared with traditional harvesting system which recorded the maximum cost requirements of 327.21 L.E/fed.


A pair of breeding Spotted Harriers Circus assimilis was observed in an agricultural environment near Tamworth, New South Wales, in winter–spring 2020 for 290 hours over 68 days from pre-laying and incubation to the post-fledging period. Laying occurred at the end of June, hatching at the beginning of August and fledging in mid September. Only the female incubated and brooded, and the male supplied all prey from the incubation period to late in Week 3 of the nestling period, after which the female contributed. Two chicks fledged of three that hatched; there was some sibling competition for food. The incubation period lasted 34 ± 1 days, and the nestling period 43 days for the older (female) chick and c. 40 days for the younger (male) chick. Prey consisted of ground-dwelling small mammals, birds and reptiles that are typical of agricultural land. The male's prey-delivery rate to the incubating female was 0.22 item/h. Overall, the male delivered 0.31 item/h and the female 0.09 item/h to the nestlings, for a combined average of 0.4 item/h, peaking in the pre-fledging fortnight. The combined rate in the post-fledging period was 0.39 item/h (Week 1), declining to 0.16 item/h to the fledglings in Week 2 when only the male delivered prey and the adult female consumed some of his catch. Estimated biomass delivered ranged between ~20 and ~100 g/item (often 20–50 g/item). Breeding behaviour and nestling/fledgling growth and development are described. The juveniles appeared to be dependent or partly so for at least 3 weeks, and apparently roosted in the nest area in Week 4, after which they could not be located.


I remind you of my earlier submission to your plan for national action for sustainable development, which was made before I received your current paper and questions on this topic. I attached an article entitled 'Open education management and communication strategies to implement regional health and sustainable development goals'. I have now received the National Action Plan for Sustainable Development and provide a response to the following key questions.


ABSTRACT Some philosophers argue that all concepts cannot have the same representational structure, because no single kind of representation has been successful in accounting for the phenomena related to the formation and application of concepts. Here, I argue against this "appeal to cognitive science" by demonstrating that different theories of the kind concept cohere with different interpretations of the argument. To circumvent the threat of relativism, I argue that theories of concept should be understood as working hypotheses, which are provisionally accepted to facilitate the investigation and explanation of the mind/brain. From this perspective, theories of concept are to be evaluated as part of a comparative analysis of the different kinds of cognitive science they inspire.


In this paper, a new MAC protocol, called Reliable Busy Tone Multiple Access with Neighboring Information Table (RBTMA-NIT), is proposed for safety applications in Vehicular ad hoc networks (VANETs). Derived from the conventional busy tone multiple access (BTMA), RBTMA-NIT introduces three mechanisms to reduce the transmission delay of emergency messages: 1) the original emergency message and its copies are assigned two different priorities; 2) a table, called neighboring information table (NIT), is built to reduce the redundant transmissions; and 3) the contention policy is improved by selecting feasible nodes, setting suitable contention window and limiting the transmission time of message on each node. Simulation results demonstrate that the proposed MAC protocol can effectively reduce the covering time during which all nodes in the system have received the emergency message.


Although tremendous effort and finances were spent in developing small animal PET scanners, this technology remains under utilized as a research tool to study disease states. To advance this goal, we previously developed a microfluidic blood sampling device to overcome the problem of blood sampling and fluid volume loss when performing quantitative PET studies. The device was previously shown to be reliable for deriving input function without changing the physiological stability of a mouse. In this study, we improved methodologies and optimized the animal surgical preparation necessary for prolonging the patency of chronic indwelling catheters. We have also added several features to improve functionality and ease of use for a new prototype of a microfluidic blood sampler and tested this device for accuracy in determining FDG blood curves in rats with a chronic indwelling catheter. We modified the hardware and software of the previous blood sampling device to reduce the cost and provide a more user-friendly interface. We successfully prepared the animal for deriving input functions for multiple microPET studies. Our results suggest that longitudinal microPET imaging in the same animal is possible. These new developments should increase the use of PET imaging in drug development and translational research using small animals.


Natural killer cells are critical in the immune response to infection and malignancy. Prior studies have demonstrated that Crk family proteins can influence cell apoptosis, proliferation, and cell transformation. In this study, we investigated the role of Crk family proteins in mouse NK cell differentiation and host defense using a mouse CMV infection model. The number of NK cells, maturational state, and the majority of the NKR repertoire was similar in Crk x Crk-like (CrkL)–double-deficient and wild type NK cells. However, Crk family proteins were required for optimal activation, IFN-γ production, expansion, and differentiation of Ly49H+ NK cells, as well as host defense during mouse CMV infection. The diminished function of Crk x CrkL–double-deficient NK cells correlated with decreased phosphorylation of STAT4 and STAT1 in response to IL-12 and IFN-α stimulation, respectively. Together, our findings analyzing NK cell–specific Crk-deficient mice provide insights into the role of Crk family proteins in NK cell function and host defense.


In any number of spacetime dimensions, it is shown for massless particles that the usual spin-statistics connection that tensors or spinors are, respectively, bosons or fermions follows from the requirement of causality. Such fields are uniquely constructed as linear combinations of annihilation operators for particles and creation operators for antiparticles. In contrast to the massive case, there is no constraint on the existence of Majorana-type fields in any number of dimensions. The situation is also examined that allows reversal of the spin-statistics connection without contradicting causality as in the case of Faddeev-Popov ghosts.


Read more and get great! That's what the book enPDFd endocrine management of cancer will give for every reader to read this book. This is an on-line book provided in this website. Even this book becomes a choice of someone to read, many in the world also loves it so much. As what we talk, when you read more every page of this endocrine management of cancer, what you will obtain is something great.


The purpose of this article is to critique the ruling view which considers the Achaemenid government as the joint government of Mad and Pars. Iranian empire was not an ally of the Median state, and it was not essentially formed except through the rejection of the Medes. Iranian empire was a Persian-oriented system that developed only in opposition to the Medes. I have challenged common but baseless theories of the shared domination of Mede and Pars and the satisfaction of the Medes from the domination of Pars with the help of valid sources.

The basis of the Iranian government has been the tool of ethnic domination of Pars on Mede. The Achaemenids/Persian Empire was formed through the military defeat, suppression, and marginalization of the Median empire. Even the Iranian symbols and works such as Persepolis and the inscription of Bistoun are reminiscent of their victories over the Mede. Furthermore, the Persian language did not come into existence through internal evolution, but Darius overnight ordered Elamite and Babylonian scribers to write it on the inscription of Bistun to preserve the memory of the victory of the Persians on the Medes. Mede and their rituals were entitled as Ahriman, Daoi Mazina, Div, Ajidahak/Zahak, Afrasiab, and Turanians, and the alien agent in Iranian mythology and culture. The controversy over totem symbols like bull and lion, and snake and eagle is the abstraction of the ethnic struggles of Persians and Medians.


An amplitude discrimination method to distinguish "1ldquo'or "0" by height of the amplitude is used for the discrimination method of a reproduced signal in a current hard disk. The SNR often deteriorates by the thermal noise that a head emits in this method. As a result, waveform interference may cause, and we cannot recognize a high-density signal precisely. Because the neural network based waveform discrimination method used in this study judges "1ldquo'or "0" with a characteristic of a waveform, it is expected that it can recognize a high-density signal. By a conventional experiment, we obtained an error rate characteristic. In this study, we extracted a worst pattern of an error rate characteristic. As a result, it is shown that the signal waveform includes its characteristic and there is "easiness" and "difficulty" to reproduce. In addition, under the condition; a first-order differential waveform, 8-6 hidden layer and normalized linear density K = 4.0, the form of a BER (bit error rate) curve, of all patterns almost accorded with the mean of bad pattern BER. According to this result, it is considered that the error rate evaluation time of a signal becomes shorter.


The past decades have seen a massive expansion of the field of wellbeing, happiness and the environment. The pertinent literature has used the term 'happiness' in a wider and a narrower sense. In the wider sense, happiness denotes what psychologists refer to as subjective wellbeing (SWB). As suggested by Diener (1984), SWB encompasses an affective and a cognitive component, that is, emotional states and evaluations of life, respectively. While happiness in the narrow sense refers to the affective component, the cognitive (evaluative) component is usually referred to as life satisfaction. However, since measures of affective and cognitive wellbeing are typically highly correlated with each other, it is nevertheless common to neglect the difference between them and to use the terms SWB, happiness and life satisfaction synonymously. We follow this practice unless stated otherwise. Data on SWB are routinely elicited in large-scale social surveys at both the national and international levels. Important national data sources, among others, include the Keio Household Panel Survey (KHPS), the German Socio-Economic Panel (SOEP) and the UK Household Longitudinal Study (UKHLS). At the international level, SWB data are included, among others, in the Eurobarometer Surveys (covering the member countries of the European Union), the European Social Survey (covering 36 European countries), the World Values Survey (covering more than 80 countries worldwide) and the Gallup World Poll covering (156 countries). In these and similar surveys, people are asked questions about their happiness or life satisfaction. The European Social Survey, for instance, regularly asks representative samples of people. 'How happy are you?' (on a scale from 0 5 extremely unhappy, to 10 5 extremely happy) and 'All things considered, how satisfied are you with your life as a whole nowadays?' (from 0 5 extremely dissatisfied, to 10 5 extremely satisfied). While the samples used in international surveys typically change over time, national surveys like the KHPS, SOEP and UKHLS rely on fixed sets of people over several years, thus allowing longitudinal analyses of SWB and its correlates. While SWB started to be studied by psychologists in the late 1940s (Diener et al., 1999), Easterlin (1974) was the first to focus explicitly on economic factors. His finding of a stationary level of self-rated happiness in the United States of America (USA), in spite of tremendous income growth, became known as the Easterlin paradox and is probably the best-known result in the economics of happiness. In addition to income, other economic correlates of happiness include unemployment, inflation and inequality. Survey articles on happiness and economics are Frey and Stutzer (2002), Kahneman and Krueger (2006), Di Tella and MacCulloch (2006), Dolan et al. (2008) and Graham (2017); a recent monograph is Frey (2018).


In this paper, a theoretical model based on Hamilton's principle and spectral analysis is used to obtain a solution for geometrically non-linear vibration of symmetrically and asymmetrically cross ply laminated skew plates. The Analysis was considered regarding the influence of different parameters such as fiber orientation, ply properties, plate skew angle and aspect ratio. Comparison between the numerical and analytical results and those available in previous studies showed a good agreement. The associated non-linear bending stresses were calculated and compared showing a higher increase with increasing the skew angle for asymmetrically laminated composite skew plates.


Submitted for the DAMOP12 Meeting of The American Physical Society Dynamics of a Quasi-1D Bose Condensate in a Double Well Potential Intermediate Between the Tonks-Girardeau (TG) and GrossPitaevskii Regimes1 T. BERGEMAN, SUNY Stony Brook, ZHEDONG ZHANG, SUNY Stonybrook — Dunjko et al. [1] have shown how results of Lieb and Liniger [2] can be used to calculate the ground state of 1D bosons in a harmonic trap, for densities varying between the TG and GP regimes. Berman et al. [3] have shown that dramatic effects in the entropy occur in the transition between these regimes. As we are not aware of predictions for the dynamical behavior of quasi-1D Bose ensembles in double well potentials, we are attempting to adapt approaches of [4] to model oscillations through a barrier of varying height. Simple time-dependent GP equations reveal damping, but what happens at low density is not yet known. [1] V. Dunjko, V. Lorent, and M. Olshanii, PRL 86, 5413 (2001). [2] E. Lieb and W. Liniger, PR 130, 1605 (1963). [3] G. P. Berman et al., PRL 92, 030404 (2004). [4] R. Pezer and H. Buljan, PRL 98, 240403 (2007). 1Supported by US NSF. T. Bergeman SUNY Stony Brook Date submitted: 26 Jan 2012 Electronic form version 1.4


In a social scenario in which technologies are gradually becoming more prominent, the educational context is an area that can not be exempt from its integration, one of the most relevant milestones in this process being the introduction of video games in teaching. This resource, which was not originally intended for educational purposes, is a very interesting element to introduce ICT across the curriculum.
This work constitutes an approximation to the gamification in education, explaining its advantages and disadvantages and how it affects the motivation of the student, the development of the classes and the academic results obtained by the students and, finally, connect it to an intervention proposal Designed to work in 3o of ESO.
The introduction of an innovative methodology in the classroom involves reformulating the development of classes to adapt everything that happens in the framework of the learning process to the instruments used, for which the most recent and relevant literature on gamification will be reviewed. Build on this a viable proposal that fits the profile of the students and the resources available.


Rock avalanches are one of the most hazardous landslide phenomena. They involve huge, extremely rapid flowing masses, carrying a strong power of destruction and reaching high mobility. The present article shows results of back-analysis of the Potrero de Leyes case in the Argentinian Andes. This rock avalanche has travelled on an unconstrained topography showing a great mobility, even without any channelizing effects. Simulations are carried out with VolcFlow, a continuum model, first on an unconstrained granular flow experiment and then on Potrero de Leyes. Results show that frictional model works well for the experiment, but that it can only reproduce the longitudinal runout in the field, and this provided that the basal friction angle used is close to the corresponding measured Fahrböschung. Here, where the rock avalanche starts as a coherent mass that disaggregates and shatters only during its propagation, lateral spreading is overestimated and a viscous behavior produces better results. characterized by a nearly oval, trapezoidal or tongue shape (see figure 1b). The Frank slide (fig. 1b), which took place in 1903 in the southern Rocky Mountains of Canada, is an example of this kind of rock avalanche (Cruden and Martin, 2007, Charrière et al., 2016). Finally, the low mobility ones are characterized by a reverse T-shape (see figure 1c), caused by the high energy dissipating impact with the opposite slope. A typical example is the Valpola rock avalanche (see figure 1c), which took place in Italy in 1987 (Azzoni et al., 1992). Figure 1. Sketches of typical shapes and picture of related examples of rock avalanches according to the classification of Nicoletti and Sorriso-Valvo (1991) and Corominas (1996): a) Hour glass shape and Pandemonium creek rock avalanche (source: Province of British Columbia); b) trapezoidal shape and Frank slide rock avalanche (source: Alberta Community Development); c) inverse T shape and Valpola rock avalanche (source: Azzoni et al, 1992). Adapted from Manzella (2008). Several models have been developed to try to simulate the propagation of these dangerous and high-mobile phenomena. In particular, because of their flow-like behaviour, continuum mechanics models based on the St Venant equations of unsteady flow and on the work of Savage and Hutter (1989) are often used to model their propagation, e.g. Hungr (1995); Mangeney-Castelnau et al. (2005); Pirulli and Mangeney (2008); Pudasaini and Hutter (2007). In order to be able to use them in a hazard predictive perspective, models validation on laboratory experiments and back-analysis of cases history become crucial, e.g. (Constantinescu et al., 2011). They improve our understanding of the most suitable rheology and of the propagation and emplacement processes. They help us detecting advantages and limits of the different codes, refining their development and employment and consequently improving modelling and assessment of area at risk. In the present study an unconstrained granular flow experiment carried out at the University of Geneva and the case of Potrero de Leyes rock avalanche were considered. This case history was chosen because, even if data available are limited and the accuracy is not very high, it represents a rare case of a well-preserved unconstrained rock avalanche. This event is very interesting to be studied since even if there is not a channelizing effect and it belongs to the aforementioned category of intermediate mobility flows, it happened to have a very low Fahrböschung. In addition unconstrained granular flows pose often problems to numerical modelers because of the difficulty in simulating lateral spreading with the lack of topographical constrains. To back-analyse these data a continuum mechanics model developed at the Laboratoire Magmas et Volcans (Clermont-Ferrand, France), VolcFLow (Kelfoun and Druitt, 2005, Kelfoun et al., 2009), was used. Main parameters were changed and different rheologies were tested to try to fit not only the runout and spreading of the mass but also the thickness of the final deposit. This has allowed improving our understanding of unconstrained type of flow and to have an idea of the kind of rheology that could be used for a first approximation hazard assessment in the region of interest.


The synergistic photocatalytic Fenton reaction is a powerful advanced oxidation technique for the degradation of persistent organic pollutants. However, microware-induced thermal effects on the formation of novel structures facilitating the photocatalytic degradation have been rare reported. Herein, a two-step microwave thermal strategy was developed to synthesize a new hybrid catalyst comprising defective WO3-x nanowires coupled with reduced graphene oxides (rGO). Conventionally, microwave methods could induce super-hot spots on GO surface, resulting in the site-specific crystallization and oriented growth of WO3. While, in the solid phase, localized microwave thermal effects could reduce interfacial area between WO3 and rGO and enhanced the bonding between them. As for the unique structure and surface properties, the synthesized catalyst enhanced the light absorption, promoted the interfacial charge separation, and increased the carrier density in the photocatalytic processes. In addition, surface formation of W4+ provided a new pathway for Fe3+/Fe2+ cycling which linked the photocatalytic reaction and Fenton process. The optimized catalyst exhibited a remarkable performance in degradation of bisphenol A (BPA) with ~83% removal yield via a photo-Fenton route. This microwave-induced functionalities of materials for synergistic reactions could also give a new avenue to other photoelectrocatalytic field and solar cells.


Although students of the fifth century A.D. have not been slow to recognize the merits of the ͉στορ⋯α Βυζαντιακ⋯ of Priscus, few efforts seem to have been made to under-stand this historian's methods of composition. The purpose of the present note is to indicate that the literary fashions of his time have exercised an unfortunate influence on at least one part of Priscus' work.


This thesis presents an analysis of the manner in which the current Canadian government, under Stephen Harper, has been using specific linguistic strategies in their environmental discourse in an effort to maintain their power. This research was undertaken utilizing a combination of content analysis and critical discourse, using Edelman's (1967) typology of language as a guiding framework. In total, nine speeches and 49 press releases were analyzed using this methodology. The findings indicate that government language influences government power insofar as government language functions as a type of strategic action that government can use to mobilize support amongst members of its target audiences.


In this study, the physical carrying capacity, real carrying capacity and permissible carrying capacity of recreational boating for mangrove forests of Hara-e Rode Gaz international wetland has been estimated. This area has a unique mangrove ecosystem. Unfortunately, an increasing number of visitors to the protected areas, apart from economic benefits, have created many problems and environmental damages, so the need for effective management of tourism in protected areas will be felt more than ever. One of the best solutions for preventing and reducing problems in protected areas is estimating the carrying capacity. In this paper, the carrying capacity of recreational boating for Mangrove forests of Hara-e Rode Gaz international wetland has been estimated. For estimating the physical carrying capacity (PCC), the wetland area and the required area for each boat was used and physical carrying capacity was estimated using existing formula. For estimating the real carrying capacity (RCC), the corrective factors (Cf) include very hot days, stormy and rainy days and season of birds breeding have been applied to the PCC. Finally, for estimating the permissible carrying capacity, Infrastructure Capacity and management capacity were estimated and applied to the RCC. Results showed that the physical carrying capacity is 380 boat/day, real carrying capacity is 166 boat/day and Effective or Permissible Carrying Capacity is 41 boat/day.


Details are presented for the measurement and prediction of aircraft flyover noise to be used for certification, research and development, community noise surveys, airport monitors, and pass fail criteria. Test details presented are applicable to all types of aircraft, both large and small, and the use of Federal Aviation Regulations (FAR) Part 36 (ref. 1) is emphasized. Accuracy of noise measurements is important. Thus, a pass-fail criterion should be used for all noise measurements. Finally, factors which influence the sound propagation and noise prediction procedures, such as atmospheric and ground effects, are also presented.


'no systematic consultations' between France, Germany, and the US about Ostpolitik (p. 230). Instead, two other triangles existed: 'one between Paris, Moscow and Bonn, . . . and one between Paris, Washington, and Moscow'. The fact that Soutou was given room to argue against the hypothesis of this book speaks of its strength. The book could be criticized on the foundations of its 'analytical construct' or because not all chapters are consistent in their attention to it. Nevertheless, overall it is a fine publication which raises important questions about trilateral French–German– US relations and sees impressive historians and political commentators scrutinize them and offer judgements which will inspire further research and debate.


In order to extend the communication range of the 60-GHz band broadband communication system, beam forming technology has been introduced. Due to the relatively high insertion loss and high phase/amplitude errors of 60-GHz band radio frequency (RF) phase shifter, broadband base band (BB) phase shifter has been focused. In this paper, we have developed a beam forming CMOS receiver RF integrated circuits (RFIC) with 5-bit BB phase shifter for the use in phased array antenna (PAA) receiver module employing 3-dimensional (3-D) system in package (SiP) technology. The receiver RFIC consists of a 7-stages low noise amplifier (LNA), an on-chip balun, a down-mixer, a quadrature-mixer, and a 5bit BB phase shifter. To obtain the broadband characteristic of 2 GHz at RF (i.e., 1 GHz at BB), BB phase shifter has been carefully designed. By using fixed-gain amplifier matrix configuration instead of variable gain amplifiers, broadband and low phase/amplitude errors are obtained. The fabricated receiver RFIC in 90-nm CMOS process exhibits performance applicable to 60-GHz band broadband communication such as IEEE 802.15.3c (channel 2).


The aim of this paper is to present PA-CONECTA software. This software is used to analyze coverage levels for multi-cell radiocommunication systems. The kernel is based on PO-ML-BSP algorithm in which physical optics (PO) approximation is combined with BSP (Binary Space Partitioning) and a multilevel (ML) scheme in order to reduce the computational cost. The software consists of different modules: geometry module allows the user to load the terrain or geometry. With PO-ML-BSP module you can select the number of domains and levels into which the space is divided. Base stations and antennas settings are defined in a new window and afterwards electromagnetic fields are calculated. Some graphic examples are shown.


We have developed a new instrumentation technique for Si crystal growth process of Czochralski (CZ) method for the purpose of the quality improvement. The online measurement technique for the melt surface level of Si crystal in growth furnace using image of the fusion ring, which appears to surround solid liquid boundary of Si ingot, was developed. Our new technique can measure the melt surface level with high accuracy without the following influences, ( i ) the change of solid liquid boundary height during diameter change, and (ii) the habit lines of Si ingot. The accuracy of this method is confirmed within +/ -0.6mm. This technique contributes to the improvement of CZ Si crystal quality.


Owing to the practical production needs,a comprehensive management system of oxygen cylinder,based on bar code,is constructed,with the information management functions in inspection,filling,quality testing,sales,and report form inquiring and statistics.Thus,a computer dynamic management of oxygen cylinder information is realized.


Background
 Azacitidine (AZA) is one of the hypomethylating agents (HMAs) proven to significantly prolong overall survival (OS) for patients with higher-risk myelodysplastic syndromes (h-MDS) via a prospective phase 3 trial. However, the optimal treatment schedule of AZA for h-MDS has not yet been prospectively determined. As a 7-day treatment schedule includes weekends, a 5-day administration has also been applied with h-MDS, though solid evidence has not been established. Based on this background, we planned to compare AZA treatment on 7-day and 5-day schedules.
 Patients
 Patients diagnosed with de novo or treatment-related MDS (FAB-defined RAEB and RAEB-t), aged 16 years or older were eligible for this study, if they showed adequate performance status (ECOG PS 0-2) and no history of HMA treatment or chemotherapy. Candidates for allogeneic stem-cell transplantation were excluded.
 Study design
 This was a multicenter, randomized, open-label, phase 3 trial to compare the efficacy of AZA treatment for 7-days (AZA-7) to 5-days (AZA-5). The primary endpoint was 2-year OS rate (2y OS). AZA was given subcutaneously at 75 mg/m² every 28 days. To test the non-inferiority of AZA-5 to AZA-7, 2y OS of AZA-7 was estimated at 30%, and the delta was defined as 11%, for which 410 patients were needed to complete the trial. However, because of the poor recruitment, this study closed prematurely, and the protocol-planned interim analysis (when 200 patients were registered) was performed. This protocol was approved by the IRB at each trial center. All patients provided written informed consent, and the trial was conducted in accordance with the Declaration of Helsinki. The efficacy of AZA was evaluated using IWG2006 criteria, and treatment was continued until study completion, or relapse, unacceptable toxicity, or disease progression was observed. Efficacy was analyzed by intention-to-treat. Secondary endpoints were the hematological response rate, 2-year leukemia-free survival (2y LFS) rate, the cytogenetic response, and occurrence of adverse events.
 Results
 Between January 2013 and Jun 2018, 201 patients were randomly assigned to AZA-7 (n=99) or AZA-5 group (n=102). The median age of all patients at the enrollment was 73.5 years old (range, 48 to 91). Between the two groups, there was no significant difference in the baseline characteristics, such as sex, type of MDS (de novo or treatment-related), percent of BM blasts, FAB and WHO classification, and IPSS and IPSS-R risk. After excluding 5 and 6 patients from AZA-7 and AZA-5, respectively (poor data entry, change in diagnosis), at the time of last follow-up, 59 and 67 patients died in AZA-7 and AZA-5, respectively. The Kaplan-Meier estimates of the 2y OS and 2y LFS were 35.1% (95% CI, 23.8 to 46.7) and 27.3% (95% CI, 17.3 to 38.3) for AZA-7, and 22.4% (95% CI, 13.1 to 33.3) and 20.5% (95% CI, 11.6 to 31.2) for AZA-5, respectively. There was no significant difference in the frequency of erythroid, platelet or neutrophil improvement, or hematological response (complete or partial response, or any hematological improvement) between the two groups. The most common non-hematological adverse event of grade 3 to 4 (in ≥20% of the patients in either group) was febrile neutropenia (33.7% for AZA-7, and 30.5% for AZA-5).
 Conclusion and Discussion
 Because of the premature termination of this trial, statistical analysis for the primary endpoint (2y OS of 35.1% for AZA-7, and 22.4% for AZA-5) could not provide any solid evidence. However, considering the difference of more than 10% in 2y OS, and no major differences in the safety profiles, we favor AZA-7 to AZA-5 for MDS patients with RAEB and RAEB-t.
 Figure

 Kiguchi: Tejin Co., Ltd.: Research Funding; Taiho Pharmaceutical Co., Ltd.: Research Funding; SymBio Pharmaceutical Co., Ltd.: Research Funding; Celgene Co., Ltd.: Research Funding; Janssen Pharmaceutical Co., Ltd.: Research Funding; Sumitomo Dainippon Pharmaceutical Co., Ltd.: Research Funding; Novartis Pharmaceutical Co., Ltd.: Research Funding; Nippon Shinyaku Co., Ltd.: Research Funding; Astellas Pharmaceutical Co., Ltd.: Research Funding; MSD CO., Ltd.: Research Funding; Kyowa Hakko Kirin Co., Ltd.: Research Funding; Otsuka Pharmaceutical Co., Ltd.: Research Funding; Bristol-Myeres Squibb Co., Ltd.: Research Funding; Sanofi K.K., Ltd.: Research Funding; Celltrion, Inc.: Research Funding. Usuki:Daiichi Sankyo Co., Ltd.: Research Funding, Speakers Bureau; Astellas Pharma Inc: Research Funding, Speakers Bureau. Suzuki:kyowa Hakko Kirin: Consultancy, Honoraria; MSD k.k.: Research Funding; Nippon Shinyaku: Honoraria; Novartis: Honoraria; takeda: Research Funding; Incyte and Pfizer: Research Funding; astellas: Research Funding; Celgene: Honoraria; Chugai: Honoraria, Research Funding; daiichi sankyo: Research Funding; eisai: Research Funding. Tomita:Chugai Pharmaceutical Co., Ltd.: Honoraria, Research Funding; Kyowa Kirin: Research Funding; Taiho Pharma: Research Funding. Handa:Ono: Research Funding. Maeda:Janssen Pharmaceutical K.K..: Honoraria; Nippon Shinyaku Co., Ltd.: Honoraria. Iyama:Otsuka Pharmaceutical Co., Ltd.: Honoraria; Otsuka Pharmaceutical Factory: Honoraria; Astellas Pharma: Honoraria; Daiichi Sankyo: Honoraria; Allexion Pharma: Honoraria; CSL Behring: Honoraria. Yamauchi:Astellas, AbbVie: Consultancy; Pfizer, Chugai, Teijin, Solasia: Research Funding. Kiyoi:Daiichi Sankyo Co., Ltd: Research Funding; Bristol-Myers Squibb: Research Funding; Pfizer Japan Inc.: Honoraria; Nippon Shinyaku Co., Ltd.: Research Funding; Otsuka Pharmaceutical Co.,Ltd.: Research Funding; Perseus Proteomics Inc.: Research Funding; FUJIFILM Corporation: Research Funding; Astellas Pharma Inc.: Honoraria, Research Funding; Zenyaku Kogyo Co., Ltd.: Research Funding; Chugai Pharmaceutical Co., Ltd.: Research Funding; Sumitomo Dainippon Pharma Co., Ltd.: Research Funding; Eisai Co., Ltd.: Research Funding; Kyowa Hakko Kirin Co., Ltd.: Research Funding; Takeda Pharmaceutical Co., Ltd.: Research Funding. Miyazaki:Chugai: Research Funding; Otsuka: Honoraria; Novartis: Honoraria; Nippon-Shinyaku: Honoraria; Dainippon-Sumitomo: Honoraria; Kyowa-Kirin: Honoraria.