The three writers in Hebei Province who are called "the three carriages" in the mid-1990s, He Shen, Tan Ge, and Guan Renshan, published their representative work successively and raised a "realism shock wave". There are reasons for the success of "the three carriages". There are some changes of the theme, literature field of vision, and criticizing spirit in their later period of writing.


It was expatiated on the implemental cruces in course of actualizing about the principle of collectivity project designing and engineering actualizing, running maintenance, etc.


Objective Observe intrauterine devic(IUD) postmenopausal women who take embedded under hysteroscopy meal of clinical effects.Methods Preoperative oral Nilestriol,vaginal placed misoprostol for cervical preparation,intraoperative under hysteroscopic to take.Results All of the patients took is successful.Condusion In the preoperative cervical prepare adequately for under hysteroscopy in postmenopausal women who take IUD embedded meal is a safe and effective method.


This paper focuses on the increasing competition between exchanges for listing similar index futures contracts and the impact this has on information dissemination between various markets. Specifically, using both the Hasbrouck and Gonzalo–Granger methodologies for extracting the information content held in each market, a comparison of information efficiencies between the Singapore Exchange and the Taiwan Futures Exchange is examined for Taiwan Index Futures listed in both markets. The results show not only a common stochastic trend between index futures and their underlying indices, but also provide strong evidence to suggest price discovery primarily originates from the Singapore futures market. There are direct implications of this result for both financial exchanges and traders—in particular, that traders realize price determination can arise from both futures markets, and the need for exchanges to maintain a reputation as an information center for these similarly traded financial instruments. © 2002 John Wiley & Sons, Inc. Jrl Fut Mark 22: 219–240, 2002


on this paper, we proposed a new text line segmentation of handwritten and typewriting Arabic document images that uses the Outer Isothetic Cover (OIC) algorithm of a digital object. In the first step, we use this method to segment the composed document into text blocs. In the second step, for each text bloc we will extract the text lines. Finally, line text will be segmented into words or into pieces of Arabic word (PAWs). The first results obtained in the current stage of the proposed method over a dozen texts are encouraging. We have also tested this method on documents written in Latin scripts. Keywords—handwritten and modern document; text line segmentation; document image; pieces of Arabic words


The structure of the proton is one the most important and most studied topics in nuclear physics. However, discrepant measurements of the proton's electromagnetic form factor ratio, GE/GM, seriously jeopardize a definitive understanding of the proton's structure. Measurements of GEGM using the Rosenbluth separation technique disagree with those using polarization transfer methods by about a factor of three at Q2∼5.6 GeV2. It has been hypothesized that this discrepancy is due to two‐photon exchange (TPE) effects that are not part of the usual radiative corrections. Theoretical corrections for the TPE effect are difficult due to the fact that a large number of excited nucleon states can contribute to the process. However, the TPE effect can be directly determined by measuring the ratio of the positron‐proton to electron‐proton elastic scattering cross sections, R = σ(e+)/σ(e−), as the TPE effect changes sign with respect to the charge of the incident particle. A brief test run of a modified beamline and the...


A local papaya cultivar (Meizhonghong) was hybridized with a cultivar introduced from abroad (Columbia). The PRSV-resistant plants selected from the F_1s were crossed with the resistant line Lingnan 1. As a result, 3 PRSV-resistant strains with high yield and good quality (Zhongcun 1, Xialan 1 and Zhongcun 3) were developed. Inoculation test and field observation showed that Zhongcun 1 has considerably high and stable horizontal resistance to 3 strains of the virus.


This study aims at an appraisal of marketing systems of paddy available for farmers in Thiruvarur district in terms of marketing channels, marketing cost, marketing margin, price spread and marketing efficiency. The Sample consists of 600 farmers who have been classified as small and large farmers according to their land holdings. Proportionate random sampling technique was adopted. In order to identify the key factors of marketing paddy in the study area, a Multiple Linear Regression Model, Garrett's Ranking Technique, Shepherd's Formula, Acharya and Agarwal's Formula and Composite Index Methods were used. The structural differences between small and large farmers were tested by using Chow's F-test. The results revealed the importance of middle man in the chain of marketing that starts with the producer and ends with the consumer. The study has also elucidate fruitful suggestions for the betterment of the farmers, to encourage Government machinery and to avoid exploitations of middle man of Thiruvarur District , TamilNadu.


Objective: To determine if adults with ADHD differed from children with ADHD, in assessing their performance on the Conners Continuous Performance Test (CPT). Method: ADHD-diagnosed adults (n = 13) and adults without ADHD (n = 17) were tested twice on the CPT and then completed self-evaluation and attribution surveys. Results: Nonmedicated ADHD-diagnosed adults performed significantly more poorly than controls; when medicated, they performed as well as controls and significantly better than when they were unmedicated. AD/HD adults evaluated their performance accurately, whether medicated or not. They also attributed their performance to medication significantly more than to ability or task difficulty. Conclusion: Unlike children, ADHD-diagnosed adults attributed their performance to medication rather than ability or task. It remains to be seen whether this difference is associated with lower self-esteem than non-ADHD adults or if the same outcome would occur in children with ADHD if they were also tested under naturalistic conditions. (J. of Att. Dis. 2009; 12(4) 291-298)


................................................................................................................................... v TABLE OF CONTENTS .............................................................................................................. vii LIST OF TABLES ......................................................................................................................... xi LIST OF FIGURES ...................................................................................................................... xii LIST OF ABBREVIATIONS ...................................................................................................... xiii CHAPTER ONE ............................................................................................................................. 1 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Background ........................................................................................................................... 1 1.2 Problem statement ............................................................................................................ 4 1.3 Justification ...................................................................................................................... 5 1.4 Objectives of the study ..................................................................................................... 6 CHAPTER TWO ............................................................................................................................ 7 2.0 LITERATURE REVIEW ......................................................................................................... 7 2.1 State of Ghana's Forests ................................................................................................... 7 2.2 Importance of forest ......................................................................................................... 8 2.3 Sustainable Forestry ......................................................................................................... 9 University of Ghana http://ugspace.ug.edu.gh


A review of 771 thyroidectomy specimens showed an incidence of carcinomas of 4.2 per cent. Despite opinion that the incidence of carcinomas in thyroid nodules is overmphasized, it is felt necessary still to encourage the careful examination of solitary nodules in young patients.


For specific models beyond the Standard Model, the following questions will be discussed: What can we learn from precision measurements in the Higgs sector about New Physics? Can we identify the underlying model? Can we gain insight in the mechanism of electroweak symmetry breaking? For this, the impact of theoretical and experimental constraints on extended Higgssectors will be illustrated, the potential of Higgs rates for identifying the model and possible CP violation will be discussed, and the specific features of Higgs pair production in New Physics extensions will be analysed.


Cervical esophagostomy was performed in 237 patients with cancer of the head and neck. All of the patients had swallowing difficulties from either the tumor or its treatment and required extra-oral feeding. We believe this method has several advantages over other techniques. The operation can be performed as a single procedure or in conjunction with tumor resection. Cervical esophagostomy cannot be used in patients with obstruction of the thoracic esophagus or lower gastrointestinal tract. Knowledge of important anatomic relationships makes the operation easy to perform and we have had few complications and no deaths from its use.


The careful observation of the intra-ocular structures with the ophthalmoscope, continued at short intervals for a length of time, will in certain cases reveal phenomena of great interest, both in a physiological and pathological point of view. This is especially true when the patients are women and the observations extend over such epochs as pregnancy and lactation, or menstruation and the climacteric period. We have then an opportunity of watching the effect upon the cerebral circulation of those bodily states which are notoriously competent to induce changes in the mental tone of the individual, and which, in certain cases, cause a most distressing form of insanity. The phenomena of menstruation may be attended by disordered vision, and it is possible that such visual disorders are due to the general commotion to which the female organization is subjected at this time, yet such cases are rare ; and Dr. T. Clifford Allbutt, of Leeds, in his recent work, says that he has never been able to satisfy himself of their existence.* I have seen a number of cases in which photophobia and dimness of vision were complained of at the monthly periods, in which the ophthalmoscope did not reveal any disorder of the intra-ocular structures, and others again where hyperaemia of the disk and retina to a very marked degree, occur ring at the same time, was unattended by any defect of vision.


The growth of InGaN alloys via Metal-Modulated Epitaxy has been investigated. Transient reflection high-energy electron diffraction intensities for several modulation schemes during the growth of 20% InGaN were analyzed, and signatures associated with the accumulation, consumption, and segregation of excess metal adlayers were identified. A model for shuttered, metal-rich growth of InGaN was then developed, and a mechanism for indium surface segregation was elucidated. It was found that indium surface segregation only occurs after a threshold of excess metal is accumulated, and a method of quantifying this indium surface segregation onset dose is presented. The onset dose of surface segregation was found to be indium-composition dependent and between 1 and 2 monolayers of excess metal. Below this surface threshold off excess metal, metal-rich growth can occur without indium surface segregation. Since at least 2 monolayers of excess metal will accumulate in the case of metal-rich, unshuttered growth of InG...


Mancozeb (ethylene bis-dithiocarbamate) is an organometallic fungicide and is widely used in agriculture and is related to women's spontaneous abortion and menstrual abnormalities. Bone marrow mesenchymal stem cells (BMSCs) can impede endometrial fibrosis via suppressing PI3K
 pathway, but its effect on the activity of endometrial cells induced by mancozeb/EDU is unclear. This study intends to explore the protective effects of co-culture with BMSCs on endometrial cells after mancozeb/EDU treatment. Endometrial cells were randomized into control group, mancozeb/EDU
 group (mancozeb/EDU treatment), BMSCs group (cells were co-cultured with BMSCs after mancozeb/EDU treatment), and inhibitor group (treated with PI3K-Akt-mTOR inhibitor) followed by analysis of the expression of PI3K-Akt-mTOR pathway-related proteins, cell viability by MTT and cell invasion
 and migration by Transwell and scratch test. Mancozeb/EDU treatment significantly inhibited PI3K-Akt-mTOR signals and cell proliferation, increased apoptosis and decreased cell invasion and migration, which were all reversed by co-culture with BMSCs. Additionally, the co-culture with BMSCs
 modulated the In Vitro viability of endometrial cells by influencing PI3K-Akt-mTOR signal transduction pathway, which can be inverted by PI3K-Akt-mTOR pathway-specific antagonists. In conclusion, BMSCs exerted a protective effect on the In Vitro viability of endometrial cells
 by manipulating the PI3K/Akt/mTOR signal transduction, which helped to protect endometrial cells from damage caused by mancozeb/ETU treatment.


"Me, collectives, relatives": Ricœur refers to the subject of attribution of memory to close the first part of Memory, History, Forgetting, published in 2000. Ricœur mentions in this chapter the work of Alfred Schütz and phenomenological sociology. The exploration of an intermediate plan of memory (between personal memory and collective memory) in the relationship with loved ones will be the occasion for a hermeneutical detour towards this social link of proximity. "On which path of attribution of the memory are the relatives?" Ricœur asks himself. Indeed, relatives are an opportunity to think about recognition by the path of remembrance. This exploration of the attribution of memories opens the connection of memory to recognition on a particular scale of the social bond, that of proximity.


Objective To explore the hemodynamics of common carotid artery and vertebral artery before and after the induction of general anesthesia of propofol and etomidate.Methods A total of 60 patients undergoing general anesthesia operation were randomly divided into propofol group and etomidate group(each n=30).Color Doppler ultrasound was used to obtain the indexes of carotid artery and vertebral artery,including peak systolic velocity(PSV),end-diastolic velocity(EDV),blood flow(BF),average flow velocity(Vm),diastolic diameter(Dd) and systolic diameter(Ds),etc.Results The blood pressure,heart rate,Dd,Ds and BF reduced after the induction of general anesthesia with propofol(P0.05),but PSV,EDV and Vm did not change significantly.After induction of general anesthesia with etomidate,indexes except heart rate did not change significantly(P0.05).Conclusion BF of carotid artery and vertebral artery decreased,and hemodynamics changed more obviously after the induction of general anesthesia with propofol than those with etomidate.Etomidate was better for hemodynamics.


This paper presents the effect of distributed generation (DG) in voltage variation and losses on very long distribution line with multiple voltage regulator. This paper considers the operation of DG effected voltage along distribution and power loss when varying load. From this study the operation of DG has effected to voltage along the very long distribution line depended on load varying and location. Therefore, the size of distributed generation has to be carefully considered when it installed on very long distribution system.


It's a global trend of media industry to establish cross-medium-and-region media group.As a result of the partition of market and region,China is short of intensive media group in scale.Therefore,administrative measures must be taken to give full play to the fundamental role of the market in resource distribution.Risks to organize media group,when taken into account,are reversible and manageable.


Fluid is a substance that continuously deform under the influence of shear stress. Basically, fluid can be classified into two categories which are Newtonian and non-Newtonian. In reality, most fluids belong to the class of non-Newtonian fluids and one of them is Jeffrey fluid. Jeffrey fluid is also known as viscoelastic fluid that exhibits both viscous and elastic characteristics. Recently, this type of fluid have received considerable attention due to their numerous applications in industries especially in polymer industries. Due to this reason, many investigations have been made to study the Jeffrey fluid in various aspects from both analytical and numerical methods. Therefore, in this thesis, the effect of thermal radiation on unsteady magnetohydrodynamics (MHD) free convection flow of Jeffrey fluid with and without nanoparticles past an infinite vertical plate are studied. The fluid is taken electrically conducting in the presence of uniform transverse magnetic field applied in a direction perpendicular to the flow. Specifically, focused of this study is to obtain an exact solution for velocity and temperature distributions under conditions of ramped wall temperature and isothermal plate. Using the constitutive relation of Jeffrey fluid and some assumptions of physical conditions, five specific problems are modelled as partial differential equations. For the first three problems, the fluid is considered as non-rotating fluid, while in the fourth and fifth problems the rotating fluid is analyzed. An appropriate dimensionless variables are employed to the dimensional governing equations and solved analytically with the help of Laplace transform technique. The effect of pertinent parameters such as Jeffrey fluid parameter, rotation parameter, phase angle, Hartmann number, permeability parameter, nanoparticles volume fraction, Grashof number, Prandtl number, radiation parameter and time on velocity and temperature are plotted graphically and discussed in details. Numerical results of Nusselt number and skin friction for various emerging parameters are calculated and presented in tabular forms. In order to authenticate the present results, the limiting cases are provided, where an excellent agreement are found. Results obtained show that, increasing of Hartmann number tends to retard the fluid flow due to the Lorentz force effect. Increasing the values of radiation parameter led to an increase in velocity and temperature fields. Further, in the case of rotating fluid, large values of rotation parameter reduces the primary velocity but enhance in the secondary velocity. On the other hand, increasing nanoparticles volume fraction causes the velocity of non-rotating fluid increases but decreases for rotating fluid. It also found that, the fluid motion for ramped wall temperature is always slower compared to an isothermal plate. Interestingly, Jeffrey fluid can be reduced to a Second grade fluid in the absence of material parameter.


I was asked to report on the effect of economics on the development of antitrust analysis of exclusionary vertical relationships, particularly on the current acceptance of post-Chicago theories of exclusionary market power such as "raising rivals' costs" (RRC). In order to better understand the role of economics in vertical-restraints law, however, I first analyze acceptance of the "free-riding" efficiency theory. This provides a second data set. In addition, since antitrust involves balancing market-power harms with efficiency benefits, a more complete picture is achieved. I have reached three basic tentative conclusions. First, developments in economics clearly have an effect on developments in the law. This has been true for both the free-rider and exclusionary-market-power theories. However, the process by which antitrust adopts new economic concepts seems to be subject to a long lag. Second, the process appears to be subject to considerable randomness. It appears to depend on the (partly) random draw of judges, lawyers, and economic consultants. Third, when economic theories are accepted, courts often restrict their engagement with the theories. Assertion sometimes is substituted for economic evidence, and legal conclusions sometimes are overly broad.


AIM: To investigate the regulatory effect of high mobility group box protein 1(HMGB1) on STAT/SOCS signal transduction in RSC-364 synoviocytes.METHODS: RSC-364 cells induced by 10 μg/L human recombinant HMGB1 were collected at 6 h,12 h or 24 h after treatment,respectively.The cells without any treatment were also collected at same time points for normal control.The mRNA expression of STAT 1/3 was analyzed by RT-PCR.The phospho-STAT 1/3(p-STAT 1/3) and STAT 1/3 proteins were detected by Western blotting.The flow cytometric analysis(FCM) was applied to detect the protein expression of p-STAT 1/3,SOCS 1/3 and cyclin D1.RESULTS: HMGB1 at concentration of 10 μg/L significantly up-regulated the mRNA and protein levels of STAT1 expression,as well as cyclin D1 protein,and markedly increased the protein expression of p-STAT1(P0.01).Compared to control group,no significant difference of STAT3 and p-STAT3 expression was observed.HMGB1 elevated the protein expression of SOCS1,while the protein level of SOCS3 was only up-regulated at 6 h.CONCLUSION: HMGB1 may activate the process of STAT1 signal transduction and up-regulate the gene expression of cyclin D1,suggesting the role of HMGB1 in promoting the proliferation of synoviocytes.


To examine associations between UA, lean mass, and muscle strength and determine the relationship between UA and strength gains with exercise training.


The correctness of the procuratorial case handling has a significant impact on social fairness and justice, which makes it essential to review and supervise procuratorial cases. However, these cases often involve a variety of types of data items and activities and complex processing logic, which makes it difficult to check the source of the data and verify the compliance of the process. To solve this problem, we propose a provenance solution for the procuratorial case processing scenario in this paper. We first sort out four types of questions that need to be answered in the case of the procuratorate. Then we propose two kinds of provenance to give these explanations through a single instance or multiple instances. Besides, we choose graph database Neo4j as a storage plan and provide corresponding query plans for the provenance, then evaluate their performance with our prototype system and the data from procuratorial test cases. The result shows that the query efficiency of our solution will not fluctuate greatly due to the depth of the query or the amount of data, which is suitable for the work scene of the procuratorate.


Electron-transfer processes that involve single and doubly charged cations of corannulene (C20H10) and coronene (C24H12) are examined by three different mass-spectrometric techniques. Photoionization studies give first-ionization energies of IE(C20H10)=7.83±0.02 eV and IE(C24H12)=7.21 ±0.02 eV. Photoionizations of the neutrals to the doubly charged cations occur at thresholds of 20.1±0.2 eV and 18.5±0.2 eV for corannulene and coronene, respectively. Energy-resolved charge-stripping mass spectrometry yields kinetic energy deficits of Qmin(C20H=13.8±0.3 eV and Qmin(C24H=12.8±0.3 eV for the transitions from the mono- to the corresponding dications in keV collisions. Reactivity studies of the C20H and C24H dications in a selected-ion flow-tube mass spectrometer are used to determine the onsets for the occurrence of single-electron transfer from several neutral reagents to the dications, affording two different monocationic products. With decreasing IEs of the neutral reagents, electron transfer to doubly charged corannulene is first observed with hexafluorobenzene (IE=9.91 eV), while neutrals with lower IEs are required in the case of the coronene dication, e.g., NO2 (IE=9.75 eV). Density-functional theory is used to support the interpretation of the experimental data. The best estimates of the ionization energies evaluated are IE(C20H10)=7.83±0.02 eV and IE(C24H12)=7.21 ±0.02 eV for the neutral molecules, and IE(C20H)=12.3±0.2 eV and IE(C24H)=11.3±0.2 eV for the monocations.


In the very common situation of taking pictures in a night scene with artificial lighting, the light coming from the scene is not enough for most cameras. Using the exposure bracketing feature available in most photo cameras, we obtain a series of pictures taken in rapid succession with different exposure times with the implicit idea that the user picks from this set the better looking image. But often none of these images is good enough: in general, good color information is retained from longer exposure settings while sharp details are obtained from the shorter ones. In this work we propose a variational method for automatically recombining a bracketed pair of images into a single picture that reflects the optimal properties of each one. For this we introduce an energy functional consisting of two terms, one measuring the difference in edge information with the underexposed image, the other term measuring the local color difference with a warped version of the overexposed image. The method is able to handle camera and subject motion as well as noise, and the results compare favorably with the state of the art.


1 Introduction 2 What Type of Privilege? 3 Part 35 4 Instructions 5 Documents Generally Referred to in the Report 6 Pre-Existing Documents 7 Joint Experts, Statements and Discussions 8 The Status of Draft Reports 9 Changing Experts 10 Experiments and Surveys 11 Use of Reports in proceedings by Third Parties 12 Collateral Use of Expert Materials 13 Litigation Privilege-Competing Forces 14 Practical Notes and Queries


We monitored flower resources around 9 Megachile rotundata (F.) bee shelters in 7 commercial seed fields of alfalfa, Medicago sativa L. (Leguminosae) seed fields to understand better the interactions between floral resources and bee pollinators. A composite pattern of floral resource availability demonstrated an initial burst of bloom, followed by a linear decline in total flowers per raceme and an exponential decline in numbers of racemes with open flowers over the season. Open flowers per raceme declined exponentially at a more rapid rate than did total flowers per raceme, and standing crop of nectar sugar declined even more rapidly. Thus, floral resources available to bees declined to low levels within 3–4 wk of bee introduction. Pollinator activity was relatively constant within a week or 2 of release of bees into the fields. Numbers of open flowers and nectar availability declined more rapidly close to bee shelters than at a distance from them. We interpret the rapid decline in floral resources partly as a result of steady pollination over time. The decline in floral resources may contribute to poor bee yields in alfalfa seed fields.


Evaluation of manual hand tools play an important role in producing better designs that are targeted to fit the user, maximize comfort, and minimize the risk of injury. The goal of this study was to evaluate and quantify the muscle response due to a horizontal wrenching task while using four socket wrench configurations: two handle types and two handle lengths. Eleven participants in this study were instructed to loosen a bolt three times using each of the tool combinations in a random order. Activity from twelve muscles was recorded using wireless surface EMG sensors. Both the handle length and the grip type were observed to have a significant effect on the overall muscle activity. Between 5-32% reduction in muscle activity was seen in all muscles due to the longer handle, and the padded handle further reduced muscle effort by up to 13%. These findings indicate the importance of tool configuration selection in order to reduce the required force application, improve posture and reduce muscle effort required for the wrenching task.


The state of wage systems at the enterprise level, in the sectoral and regional aspects is considered. The main problems arising from the current situation in the wage system are formulated, its influence on the social and economic differentiation of society is shown, the main directions of development are revealed. The wage system, enterprise, region, industry, and standard deviation.


The way in which insects respond to high temperature is more or less known. For instance, we know that higher temperatures increase the rate of develoI)nlent of insects and favor the formation of pigments, so that " southem" varieties of butterflies, with l)righter colors, can be artificially produced. It is known also that high temperatures cause dial)auses in some insects; for examl)le, estimation may l)e ol)served in the caterpillars of L oxostege sticicalis in the steppes of the Lower Volga region. Excessively high temperatures kill insects thus, cocoons of the frit-fly are killed l)y a tellm)erature of 350 C.


A key analytical task across many domains is model building and exploration for predictive analysis. Data is collected, parsed and analyzed for relationships, and features are selected and mapped to estimate the response of a system under exploration. As social media data has grown more abundant, data can be captured that may potentially represent behavioral patterns in society. In turn, this unstructured social media data can be parsed and integrated as a key factor for predictive intelligence. In this paper, we present a framework for the development of predictive models utilizing social media data. We combine feature selection mechanisms, similarity comparisons and model cross-validation through a variety of interactive visualizations to support analysts in model building and prediction. In order to explore how predictions might be performed in such a framework, we present results from a user study focusing on social media data as a predictor for movie box-office success.


INTRODUCTION: The cement viscosity at the time of application to the bone is critical in ensuring a long-term success of the arthroplasty, as it influences the cement penetration and stability of the prosthesis. Currently, there are number of cements available with a wide range of viscosities and set times. High viscosity faster-setting cements may significantly reduce operating room times. However, the concern is that this positive feature may be at the expense of decreased penetration into the bone, and hence reduced stability of the construct.


Background Kawasaki disease is the most common cause of acquired heart disease among febrile children under the age of 5 years old. It is also a clinically diagnosed disease. In this study, we developed and assessed a novel score system using objective parameters to differentiate Kawasaki disease from febrile children. Methods We analyzed 6,310 febrile children and 485 Kawasaki disease subjects in this study. We collected biological parameters of a routine blood test, including complete blood count with differential, C-reactive protein, aspartate aminotransferase, and alanine aminotransferase. Receiver operating characteristic curve, logistic regression, and Youden's index were all used to develop the prediction model. Two other independent cohorts from different hospitals were used for verification. Results We obtained eight independent predictors (platelets, eosinophil, alanine aminotransferase, C-reactive protein, hemoglobin, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and monocyte) and found the top three scores to be eosinophil >1.5% (score: 7), alanine aminotransferase >30 U/L (score: 6), and C-reactive protein>25 mg/L (score: 6). A score of 14 represents the best sensitivity value plus specificity prediction rate for Kawasaki disease. The sensitivity, specificity, and accuracy for our cohort were 0.824, 0.839, and 0.838, respectively. The verification test of two independent cohorts of Kawasaki disease patients (N = 103 and 170) from two different institutes had a sensitivity of 0.780 (213/273). Conclusion Our findings demonstrate a novel score system with good discriminatory ability for differentiating between children with Kawasaki disease and other febrile children, as well as highlight the importance of eosinophil in Kawasaki disease. Using this novel score system can help first-line physicians diagnose and then treat Kawasaki disease early.


14057 Background: AMG 706 is an oral, investigational multikinase (MKI) inhibitor with antiangiogenic and direct antitumor activity that selectively targets VEGF, PDGF and Kit receptors. Methods: This is an ongoing phase 1b, open-label, dose-finding study of AMG 706 plus panitumumab and gemcitabine-cisplatin. Objectives are to establish the maximum tolerated dose and to assess safety, objective response and PK of AMG 706 with this regimen. Pts =18 yrs with advanced cancer, ECOG 0–1, =1 prior chemotherapy for advanced disease and no prior oral VEGFr MKIs or anti EGFR therapy, received panitumumab (9mg/kg IV day 1 of each 3-wk cycle) plus gemcitabine (1250mg/m2 IV days 1 and 8) and cisplatin (75mg/m2 IV day 1), and escalating doses of AMG 706 given continuously from day 1 of cycle 1. Assessments included dose-limiting toxicities (DLT; cycle 1), PK and tumor response (every 6–9 wks from wk 6). Results: As of Nov 2006, 36 pts (NSCLC n=19; pancreatic cancer n=4; other n=10; unknown primary n=3) were enrolled; ...


In Affine Term Structure Models (ATSM) the stochastic Jacobian under the forward measure plays a crucial role for both hedging and pricing, as discussed in Elliott and van der Hoek (2001). Here we show that its computation is equivalent to the solution of the Riccati ODE associated to the bond price. This result has remarkable consequences for the computation of dynamical hedging strategies and provides the correct multifactor extension of the traditional immunization approach.


The clinical spectrum of primary hyperparathyroidism has been greatly broadened in recent years. Initially this disease was recognized only by the presence of osteitis fibrosa cystica generalisata. 1 In 1925 Mandl was the first to excise a parathyroid tumor in a patient with classical skeletal changes. 2 Albright and his associates subsequently showed that hyperparathyroidism was more commonly associated with kidney stones. 1 More recent studies have shown an association of hyperparathyroidism with peptic ulcers, 3-8 pancreatitis, 9-11 steatorrhea, 12 multiple endocrine adenomas, 13-15 and a multitude of clinical signs and symptoms secondary to the hyperparathyroid state. 4,7 An accurate diagnosis of primary hyperparathyroidism can be made only by correlation of the clinical findings and laboratory studies. Unfortunately, there is no direct test for parathyroid gland activity, and laboratory studies depend upon indirect procedures such as the determination of serum calcium and inorganic phosphorus and the various tests of phosphate


Fault tolerance in IBM S/390® systems during the 1980s and 1990s had three distinct phases, each characterized by a different uptime improvement rate. Early TCM-technology mainframes delivered excellent data integrity, instantaneous error detection, and positive fault isolation, but had limited on-line repair. Later TCM mainframes introduced capabilities for providing a high degree of transparent recovery, failure masking, and on-line repair. New challenges accompanied the introduction of CMOS technology. A significant reduction in parts count greatly improved intrinsic failure rates, but dense packaging disallowed on-line CPU repair. In addition, characteristics of the microprocessor technology posed difficulties for traditional in-line error checking. As a result, system fault-tolerant design, particularly in CPUs and memory, underwent another evolution from G1 to G5. G5 implements an innovative design for a high-performance, fault-tolerant single-chip microprocessor. Dynamic CPU sparing delivers a transparent concurrent repair mechanism. A new internal channel provides a high-performance, highly available Parallel Sysplex® in a single mainframe. G5 is both the culmination of decades of innovation and careful implementation, and the highest achievement of S/390 fault-tolerant design.


SUMMARY The acid hydrolase N-acetyl-B-glucosaminidase (NAG) was used to examine the effects of prostaglandins E, (PGEJ), E2 (PGE2), and F2a (PGF2a) on the lysosomal system of human synovial cells in vitro. A spontaneous release of the enzyme occurred from control cultures, which was accelerated by each of the prostaglandins in a concentration-dependent manner, within the range of 10-8-10-6 moles per litre (M). No clear order of potency could be established. The effects of the prostaglandins on release of NAG were less consistent and of smaller magnitude when human serum was replaced by bovine serum albumin in the medium. In the presence of serum small increases also occurred in intracellular NAG activity, but only the effect of PGEI was statistically significant. The prostaglandins did not appreciably affect the previously established pattern of increased intracellular activity of NAG and reduced release produced by sucrose. The synovial intima includes at least 3 cell types in a ground matrix of reticulin fibres, collagen, and hyaluronic acid. Type A synoviocytes have ultra-structural and functional characteristics of macrophages.' Type B synoviocytes more closely resemble connective tissue fibroblasts and are probably the major source of the hyaluronic acid in the matrix and the synovial fluid. A third (type C) form has mixed properties of the A and B cells.2 During rheumatoid arthritis (RA) the synovial membrane hypertrophies and appears to


The authors present diffusion of innovation theory (Rogers, 2003) as a framework for integrating social justice into counselor education. An overview of diffusion theory is provided along with how the tenets of diffusion of innovation can be used to alleviate fears and anxieties that come with adopting an innovation such as social justice in counselor education.


This paper discusses the difference of computational complexity between Decisive TSP and Optimal TSP. Some mistakes in references 1~3 are pointed out.


The durability and reliability of structural components are usually assessed based on fatigue loading under operating conditions. To obtain accurate fatigue loading in the form of continuous strain histories, a novel approach is proposed based on the combination of a recurrent neural network and simplified semianalytical method. The recurrent neural network named nonlinear autoregressive model with exogenous inputs (NLARX) is applied to determine the relationship between external loads and corresponding fatigue loading. Owing to the generalization ability of NLARX, semianalytical method, which is used to obtain sample database for NLARX model training and testing, is implemented with simplified multibody model. Durability tests of a torsion beam rear suspension are introduced to demonstrate the effectiveness of the proposed approach. The experimental results show that our proposed approach is able to achieve better estimation results, when compared with the conventional semianalytical method.


The rate of canopy photosynthesis, single leaf photosynthesis, leaf resistance to gaseous exchange, and leaf water potential of simulated swards of perennial ryegrass ( Lolium perenne cv. S24) in a controlled environment, were determined during a period of increasing water stress and recovery from that stress. Canopy photosynthesis did not decline immediately water was withheld but continued at an undiminished rate for several days; thereafter it fell rapidly, particularly at first. As water stress increased successive relationships between canopy photosynthesis and irradiance became more curved, indicating that the effect of water stress increased with increasing irradiance. After the swards were re-watered canopy photosynthesis rose, most rapidly during the first 24 h. In general, the pattern of change of leaf water potential was similar to that of canopy photosynthesis, although a more detailed examination of this relationship showed it to be hysteresial ; in particular, the fall in leaf water potential preceded that of canopy photosynthesis. Single leaf photosynthesis appeared to be the main agent through which water stress influenced canopy photosynthesis although in the more severely stressed swards (leaf water potentials of about -15 bars) some leaf tissue died and so limited the recovery of canopy photosynthesis. The leaf resistance to gaseous diffusion increased with increasing water stress, as did the C02 compensation point, thereby influencing single-leaf photosynthesis and through it canopy photosynthesis.


To the editor, We read with great interest the letter from Yang et al. that raises a major issue regarding patients who received liver transplantations (LTs) who present with advanced hepatocellular carcinoma (HCC).[1] HCC is currently one of the leading indications for LT, with a recurrence rate approximately 10% at 5 years. In the case of advanced HCC, systemic treatment with a tyrosine kinase inhibitor (TKI) remains the treatment of choice in LT recipients but is associated with a poor prognosis. Recently, the Imbrave150 study prompted us to propose the combination of atezolizumab– bevacizumab as the first line for advanced HCC in patients who were immunocompetent.[2] However, no data regarding the safety and efficacy are available for LT patients as they were not included in Imbrave150. As immune checkpoint inhibitors (ICIs) block the immune checkpoint molecules, ICIs enhance T cell activation and can lead to acute cellular rejection (ACR).[3] In addition, immunosuppression (IS) goals are lowered after HCC recurrence to limit tumor progression but thus potentially exposed to a higher risk of rejection under immunotherapy. To prevent ACR, we propose to adopt a standardized IS regimen including lower therapeutic goals of everolimus and tacrolimus to allow immunotherapy treatment to be effective, reducing adverse effects. To date, two LT patients with advanced HCC were treated with atezolizumab– bevacizumab in association with standardized IS protocol (everolimus and tacrolimus 5– 7 ng/ml, mycophenolic acid 1000 mg/day, and corticosteroids 5 mg/day) in our center (Table 1). They presented metastatic tumor progression after TKI. The liver biopsy performed before treatment initiation excluded ACR, and Received: 21 February 2022 | Accepted: 24 March 2022


Counting sort is an algorithm that takes an array A of n elements in the range {1, 2, ..., k} and sorts the array in O(n + k) time. Counting sort uses no comparisons and uses the fact that the n elements are in a limited range to beat the O(n log n) limit of comparison sorts. Algorithm: Counting sort keeps an auxiliary array C with k elements, all initialized to 0. We make one pass through the input array A and for each element i in A that we see, we increment C[i] by 1. After we iterate through the n elements of A and update C, the value at index j of C corresponds to how many times j appeared in A. This step takes O(n) time to iterate through A. Once we have C, we can construct the sorted version of A by iterating through C and inserting each element j a total of C[j] times into a new list (or A itself). Iterating through C takes O(k) time. The end result is a sorted A and in total it took O(n + k) time to do so. Note that this does not permute the elements in A into a sorted list. If A had two 3s for example, there's no distinction which 3 mapped to which 3 in the sorted result. We just counted two 3s and arbitrarily stuck two 3s in the sorted list. This is perfectly fine in many cases, but you'll see later on in radix sort why in some cases it is preferable to be able to provide a permutation that transforms A into a sorted version of itself. To do this, we continue from the point where C is an array where C[j] refers to how many times j appears in A. We transform C to an array where C[j] refers to how many elements are ≤ j. We do this by iterating through C and adding the value at the previous index to the value at the current index, since the number of elements ≤ j is equal to the number of elements ≤ j − 1 (i.e. the value at the previous index) plus the number of elements = j (i.e. the value at the current index). The final result is a matrix C where the value of C[j] is the number of elements ≤ j in A. Now …


The coupled nonlinear Schrödinger (NLS) equations are usually used to describe the dynamics of two-component solitons in optical fibers. Via the Darboux transformation, the coupled NLS equations of the Manakov type are found to have triple Wronskian solutions. Proof is finished by virtue of some new triple Wronskian identities. By solving the zero-potential Lax pair, the triple Wronskian solutions give the bright N-soliton solutions which are characterized by 3N complex parameters. To obtain an understanding of the asymptotic behavior of the bright N-soliton solutions with arbitrary N, some algebraic properties of the triple Wronskian are analyzed and an algebraic procedure is presented to derive the explicit expressions of the asymptotic solitons as t → ∓∞.


The initial microbiota formation in newborns is likely to be a critical determinant in the development of certain pediatric diseases. The process is affected by many factors such as: mode of delivery, infant gestational age and postnatal age, host genetics, feeding types and nutrition, environmental factors (familial transmission), and antibiotics and/or probiotics and prebiotics use. We review hereinafter the recent knowledge of the impact of both mode of delivery and newborn diet on gut microbiota development and we also discuss the link between neonatal gut microbiota and stress-related behaviors.


We study the relation between the maximal violation of Svetlichny's inequality and the mixedness of quantum states and obtain the optimal state (i.e., maximally nonlocal mixed states, or MNMS, for each value of linear entropy) to beat the Clauser-Horne-Shimony-Holt and the Svetlichny games. For the two-qubit and three-qubit MNMS, we showed that these states are also the most tolerant state against white noise, and thus serve as valuable quantum resources for such games. In particular, the quantum prediction of the MNMS decreases as the linear entropy increases, and then ceases to be nonlocal when the linear entropy reaches the critical points ${2}/{3}$ and ${9}/{14}$ for the two- and three-qubit cases, respectively. The MNMS are related to classical errors in experimental preparation of maximally entangled states.


This paper intends to study how the religious community is determined by the geographical expression and by the political boundary. In colonial Indian census, there was a category of tribal religion which disappeared after political freedom of India. All non- Muslim and non Christian tribals were assumed as a Hindu in post colonial census. The assimilation of the faith of minority by the religious majority through the imagined political boundary or so called the national movement is part of my research endeavour. I will try to figure out how the political boundary became a determining force in reconstructing a religious community or how the faith of tribals was replaced by Hinduism. In this paper I will focus on two tribes of Chotanagpur i.e. Munda and Oraon. How the faith of tribal in general and the religion of Mundas and the Oraons in particular got changed through the concept of Indianisation will be the key point of discussion in this paper. It would be interesting to know how far the dominant majoritarian politics of Hinduism incorporated and assimilated the tribal faith into Hinduism through the 'imagined native religion' which perhaps was none other than Hinduism.


This chapter moves from the promulgation of the expulsion edict in December 1496 to the forced conversion of the Jews in 1497. The chapter examines the process by which this expulsion turned into a brutal mass conversion and delves into the fate of Jewish communal property such as synagogues. It examines how the "converse problem", which had surfaced and then abated during the reign of Joao II, suddenly re-emerged in the spring and summer of 1497 and threatened to upset the outcome of the marriage negotiations concluded in 1496. Although all the Jewish chroniclers describe appalling scenes of mass suicide, they provide neither the names nor the numbers of martyrs. Abraham Zacuto named one rabbi, who committed suicide with his sons, as Isaac ben Zahin. The letter bearing Manuel's furious reply to the Spanish court written after receiving Princess Isabel's personal demands has unfortunately not survived.Keywords: Abraham Zacuto; converse problem; expulsion edict 1496; Jewish communal property; Joao II; king Manuel; martyr of 1497; mass conversion; princess Isabel; synagogue


Alkali-activated slag (AAS) is becoming an increasingly popular building material due to its excellent engineering properties and low CO2 emissions, but its large shrinkage is an important reason to restrict its application and popularization. This work is aimed to study the possibility of inhibiting the shrinkage of AAS mortar by incorporating polypropylene fiber (PPF). For this, an experimental study was carried out to evaluate the effects of PPF content on setting time, fluidity, physical properties, mechanical properties, impact resistance, and microstructure of AAS mortar. The volume content of PPF is 0.05%, 0.1%, 0.15%, and 0.2%. The working, physical (porosity, water absorption, and bulk density), mechanical, shrinkage, and impact resistance properties of the AAS mortars were evaluated. The results show that incorporating PPF effectively reduces the shrinkage deformation of AAS mortar, significantly improves its impact resistance, enhances its toughness, and slightly improves its compressive strength in the later stage. At the same time, PPF delays the initial setting time of AAS mortar and reduces the fluidity, density, porosity, and water absorption of AAS mortar. SEM results show that the bridging effect of PPF between AAS mortars can inhibit the generation and propagation of cracks, improve the internal microstructure, and enhance the performance of AAS mortar.


Read Chapter 13. Become familiar with the risk assessment techniques presented in the chapter. Download attached files and review Chapter 13Exercise PDF file. The Excel file contains selected Chapter 13 Risk Assessment Techniques. Case Study #1 risk assessment is completed and provided as an example. Complete Case study # 2 and 3 and submit the file to your instructor.


Cross sections for ( n,2n) reactions were measured with the activation method and evaluated by the code HFTT. The excitation function curves were made out. The features of cross sections changing with the neutron energies were analyzed and compared with the literature values.


The research about characterization of the amylase enzyme from germination glutinous corn seed ( Zea mays ceratina L.) was done. The aims of this research is to know the effect of germination time to the activity of the amylase enzyme and characteristics of the amylase enzyme from germination glutinous corn seed ( Zea mays ceratina L.). The research was conducted through four phases that is germination stage, extraction, isolation, and characterization. The research device used was Completelly Randomized Design (CRD) and to be continued by BNJ test critical level 5%. Result showed that the germination time that produces the highest activity was 36 hours and the activity of enzyme was 0.0557 sec -1 . Isolation of the amylase enzyme purified by salting out method used technical (NH 4 ) 2 SO 4 at concentration 55% with activity of 0.0394 sec -1 . The optimum pH was 9, and the activity of enzyme was 0.0207 sec -1 . Maximum substrate concentration with the activity 0.0476 sec -1 give at 12.5% (w/v), while the optimum temperature for activity 0.0229 sec -1 was 70 o C. From examination manner analysis for all of free variables results very real effect on the amylase enzyme activity, while the BNJ test critical level of 5% showed a real difference with the other treatments of every variable.


kernel weight and seed vigor after milky ripening in three inbred lines of sul type sweet corn were analyzed.The germinating rate of seed was relatively high at 30 days after silking.100 kernel weight and vigor index were increased in the ripening and the maximum values of the two were realized at 50 days and 45 days after silking respectively.The best time of harvest should be at 50 days after silking.


Objective: To investigate the sffect of strengthen the check system in the operating room nursing.Methods: From March to May 2011 implementation of the general nursing intervention patients as control group,from June to August 2011 to strengthen the check system of patients as experimental group.Compared two groups of patients on the nursing work satisfaction and anxiety state.Results:After the implementation,patients′job satisfation for nurse was improved,anxiety and adverse event were reduced.Conclusion:The strengthen check system in operating room could help reduce the nursing adverse events and patients' anxiety state,it is worth the applicating.


The first section gives an overall presentation of reflection about the conceptual approach which dominated the initial formulation and developments in the law on equality between men and women in contemporary Western legal systems. The importance accorded to the concept of formal equality and the anti-discriminatory approach contributes to reduce drastically the scope and effectiveness of legislation on equality. The only possible way out of the impasse of abstract and theoretical equality is to change paradigms and base gender equality on parity, in other words recognising the fundamental right of equality between women and men. This right imposes equal status and an obligation to take the measures necessary to implement it effectively.


Abstract A synthesis of the tricyclic partly substituted core structure of palhinine A was achieved. To reach the bicyclo[2.2.2]octane motif a domino Michael reaction was employed as a key step. After Arndt–Eistert homologation and intramolecular aldol reaction the isotwistane core could be obtained after simple functional-group manipulations.


This work is a contribution to the development and implementation of non-thermal plasma technology for decontamination in the perspective of nosocomial and chronic wound innovative therapies. Multi jets devices based on Plasma Gun® technology in static and scanning operation modes and bacterial lawns inoculated with resistant and non-resistant bacterial strains were designed and used. A pilot toxicity study exploring plasma treatment of wound bearing patients, performed with a low voltage plasma applicator, is documented as a first step for the translation of in vitro experiments to clinical care. Bacterial inactivation was demonstrated for Staphylococcus aureus, Pseudomonas aeruginosa and drug resistant S. aureus, P. aeruginosa and Escherichia Coli strains collected from patient wounds at Orleans (France) hospital. A few square centimeter large contaminated samples were inactivated following a single plasma exposure as short as one minute. Samples inoculated with a single but also a mix of three resistant pathogens were successfully inactivated not only right after their contamination but for mature lawns as well. Similar bactericidal action was demonstrated for antibiotic-resistant and non-resistant P. aeruginosa. The time exposure dependent increase of the inhibition spots, following multi jets exposure, is discussed as either the accumulation of reactive species or the likely combinatory action of both the reactive species and transient electric field delivery on inoculated samples.


The article analyzes the problems of the practice of courts of general jurisdiction rules of the Code of Civil Procedure of the Russian Federation leaving the claim without movement.


This study examines the effect of demographic factors on personal financial management with spiritual intelligence as a moderating variable. The sampling technique is proportionate random sampling, the number of research samples 388 students of State Islamic University Maulana Malik Ibrahim Malang. The test results indicate an influence on personal financial management. The positive influence of demographic factors with age characteristics on personal financial management. As for the characteristics of the sex found no influence on personal financial management. Spiritual intelligence as a moderating variable is able to strengthen the relationship between demographic factors and personal financial management of State Islamic University Maulana Malik Ibrahim Malang students. Education providers to design finance education patterns can use the implications of this study for students.


Video transfer from a Pathescope reel. This was the sixth episode of Hall Roach's Our Gang series. The original title was "Saturday Morning" 1922


This study aims to comprehensively describe the issuance of Family Cards in the perspective of maslahah (social benefit) and justice for the legitimacy of marriage for sirri married couples in Bengkulu Province. This research is a qualitative empirical research with a statutory approach, a case and field approach, and a concept approach. This study found that the issuance of Family Cards for marriages of unmarried couples is a form of upholding justice in a social (commutative) framework where everyone has the same rights over marital status. On the other hand, the issuance of a Family Card for unmarried couples can be categorized as maslahah al-khassah (special benefit) which benefits only a few parties, not maslahah al-ammah (general benefit) which applies to the whole community. This study also found that the impact of including the statement "Unregistered Marriage" in the issuance of Family Cards for unregistered married couples can lead to maslahah al-mulghah in the form of legal confusion regarding the legality of one's marriage while at the same time hindering the updating of centralized data which is on the government's agenda.


Coordination within organizations has been recognized as an issue of central importance in the organizational economics literature, where the degree of interdependence between individuals' actions is taken as given. In reality, however, the degree of interdependence is affected by the choice of an organization's strategy, and hence there are inter-relationships among the interdependence of individuals' actions within organizations, their ability to coordinate their actions, and the choice of the organization's strategy. We explore these inter-relationships by focusing on coordination between engineers. In our theoretical model, we consider a firm that designs and sells a product which consists of two components, 1 and 2. Engineer i (= 1, 2), who is in charge of the design of component i, attempts to maximize component i's quality (local quality). The degree to which designs of different components interact with each other is a key determinant of success in product development. In this context, previous research on product design has found that product architecture is a useful concept. In our model, a firm can increase the product's global quality by increasing the integrality of the product's architecture. Higher integrality, however, also increases the degree of interaction between the two components' designs, making coordination between engineers more important. We hypothesize that the longer the engineers work together the better they can coordinate their actions. Our model yields the following testable prediction: "As consumers' valuation of product quality increases, the firm invests more to reduce engineers' turnover rate. A lower turnover rate, in turn, increases the integrality of the product architecture." We investigate this prediction empirically by analysing data we collected through administration of questionnaire surveys to manufacturing and software companies in Japan, Korea, and China. A novelty of our questionnaire survey is that it measures the integrality of product architecture with a continuous variable ranging from 0 to 100, whereas previous studies on product architecture are based on a dichotomy of modular or integral architecture. We test our theoretical prediction by the two-stage least squares procedure, and find empirical support for our theoretical prediction in Japan and China but not in Korea. We discuss possible reasons for the lack of empirical support in Korea.


This paper reports on a flexible flap valve actuated by electromagnetic force under a constant pressure source. The flexible flap valve consists of the three main components: a flexible flap with a steel disk embedded in PDMS, an electromagnetic actuator and two glass plates with inlet and outlet. The flap valve is fabricated by SU-8 mold process, the EDM process and oxygen plasma treatment. The dimension of an assembled flap valve is 12 [㎜] × 20 [㎜] × 28 [㎜]. The stroke volume of the flap valve is measured for various pressures. And the time of the applied input voltage is varied to change the open time of the valve. When the input voltage of 30 [V] is applied for 0.25 [s], the minimum stroke volume of the flap valve is 40 [μL] at 70 [㎪].


The article takes those companies that being given nonstandard audit advice as samples,and estimate the controllable accrued profit reflecting the extent of control of earnings.On the relationship between earnings management and corporate governance,a new and systematic research concept framework is set up,which develops explanatory variables and control variables that representing characteristics of board of directors and ownership structures and puts forward 14 phenomena.


An access detector detects an access type of an access to one of a plurality of serial ports interfacing to serial storage devices. The access is intended to one of a plurality of parallel channels interfacing to parallel storage devices via task file registers of the parallel channels. A mapping circuit maps the serial ports to the parallel channels. A state machine emulates a response from the one of the parallel channels based on the access type and the mapped serial ports.


Review(s) of: Library and information science in developing countries: Contemporary issues, ed. by Adeyinka Tella and Abdulwahab O. Issa, Hershey, PA IGI Global/Information Science Reference, 2012. 364 pp. price not reported hard cover + e-book ISBN 9781613503355 eISBN 978613503362.


In this study, the streamflow simulated by HSPF (Hydrological Simulation Program - Fortran) and a regression model were used to estimate nonpoint source loading of the Danshui catchment in Dongjiang watershed, Guangdong Province. Results showed that the regression model made a reasonable reproduction of the temporal variation of pollutant fluxes during 2010. Statistical results indicated the significant contribution of pollutant fluxes during wet season to annual fluxes. The fluxes of SS, CODCr, NO-3-N and TP contributed 86.81%, 77.56%, 69.83% and 73.08% to their annual fluxes, respectively. Regression model in this study only established the linkage between streamflow and pollutant fluxes. Other factors, such as anthropogenic activities, were not included. Thus, the weak correlation between NH+4-N, TN computed fluxes and observed value may be due to the close relationship between these nutrients and point source discharge from anthropogenic activities.


ABSTRACT The Wiggle Jig, developed in 2009 by the professional ballet company BalletMet through external funding opportunities, brings dance into early childhood education classrooms to enhance students' social, motor, and cognitive learning. Using themes such as animals and storytelling, teaching artists encourage self-expression and critical thinking skills. The Wiggle Jig program could serve as a model for other professional dance companies to provide their communities with significant educational experiences in the arts in addition to performances.


In this paper, we present a simple, lightweight, but robust security protocol for resource-constrained communications. This protocol is based on the backward property of RC4 stream cipher and achieves data confidentiality, data authentication, data integrity, and data freshness with low overhead and simple operations. Furthermore, an RC4-based hash function for the generation of message authentication code (MAC) is presented. The proposed protocol is an ideal solution for resource-constrained environments where the communication nodes have limited power resources and computational capabilities, and can be widely used in the applications of one-to-one communications as well as broadcasting and multicasting.


Abstract. Frequent sequential pattern mining in item interval extended sequence database (iSDB) has been one of interesting task in recent years. Unlike classic frequent sequential pattern mining, the pattern mining in iSDB also consider the item interval between successive items; thus, it may extract more meaningful sequential patterns in real life. Most previous frequent sequential pattern mining in iSDB algorithms needs a minimum support threshold (minsup) to perform the mining. However, it's not easy for users to provide an appropriate threshold in practice. The too high minsup value will lead to missing valuable patterns, while the too low minsup value may generate too many useless patterns. To address this problem, we propose an algorithm: TopKWFP – Top-k weighted frequent sequential pattern mining in item interval extended sequence database. Our algorithm doesn't need to provide a fixed minsup value, this minsup value will dynamically raise during the mining process


The programs of soybean breeding have sought to develop, over the years, more productive and more disease resistance cultivars. The objective of this study was to evaluate soybean cultivars and lines for agronomic characteristics and severity of foliar diseases. The experiment was conducted at the Federal University of Rondonia, in Moura-RO, the harvest 2007/2008 in dystrophic Typic. The experimental design was randomized blocks, evaluating 25 strains and five as control (Warranty, Chapadoes, Luziania, Msoy Msoy 8411 and 8914), with four replications. , Plant height at flowering and maturity, height of the first pod; lodging; leaf retention, productivity and number of days to flowering and maturity: the agronomic characteristics were evaluated. For diseases were evaluated septoria (Septoria glycines), the stain-eye frog (frogeye leaf spot) and target spot (Corynespora cassiicola), determining the severity. As for soybean rust (Phakopsora pachyrhizi), the behavior of genotypes to aggressiveness is noted. As they have good agronomic characteristics and low severity as to foliar diseases, UFUS 3, UFUS 6, 7 UFUS, UFUS 11, UFUS 14, 16 and UFUS UFUS 17 lines appear as the most promising materials for cultivation in the region of Rolim Moura-RO.


Eustachian tube (ET) dysfunction is the most important factor in the pathogenesis of otitis media and related conditions. The importance of the function of the ET in relation to the middle ear-mastoid air cell system is compared to the critical role that laryngeal function has in its relation to the tracheobronchial-pulmonary system. However, because of its obscure location, the ET is not as easily assessed by clinical or laboratory methods as is the larynx, and therefore, its function is not as well understood. Most clinicians do not include ET function testing as part of their evaluation of patients with middle ear (ME) disease. Pneumatic otoscopy, the Toynbee test, tympanometry, the 9-step inflation-deflation tympanometric test, and the patulous tube test can be performed when the tympanic membrane is intact. The modified inflation-deflation test employing the pump-manometer of the electroacoustic impedance bridge can assess the function of the ET when the tympanic membrane is not intact. These tests are helpful in the diagnosis of the presence or absence of abnormal ET function; if a dysfunction is present, these tests help to determine whether or not the tube is obstructed (mechanically or functionally) or abnormally patent, and in some instances, the degree of the malfunction. Even though testing of the function of the ET in the clinical setting has severe limitations at present, and further research is needed, information can be gained which is useful in the diagnosis and management of ME disease. Failing to recognize and assess the function of the ET in relation to the ME and mastoid in selected patients is as irrational as ignoring the function of the larynx in patients with disease of the lower respiratory tract.


The ubiquitous availability of mobile devices capable of location tracking led to a significant rise in the collection of GPS data. Several compression methods have been developed in order to reduce the amount of storage needed while keeping the important information. In this paper, we present an lstm-autoencoder based approach in order to compress and reconstruct GPS trajectories, which is evaluated on both a gaming and real-world dataset. We consider various compression ratios and trajectory lengths. The performance is compared to other trajectory compression algorithms, i.e., Douglas-Peucker. Overall, the results indicate that our approach outperforms Douglas-Peucker significantly in terms of the discrete Fr\'echet distance and dynamic time warping. Furthermore, by reconstructing every point lossy, the proposed methodology offers multiple advantages over traditional methods.


Background: Anesthetic agents are known to influence functions of the immune system. Anesthetic drugs also support cancer progression by suppressing the activity of immune cells. In breast carcinoma an increase in expression of peripheral‐type benzodiazepine receptors (PBR) and the gamma aminobutyl acid (GABA) level has been discovered. Therefore, an investigation of a direct influence of GABA‐A agonist propofol, GABA‐A and PBR‐agonist etomidate, and the local anesthetic drug lidocaine, which can also bind to the GABA‐A receptor and PBR, on migration of breast carcinoma cells was performed.


Methotrexate is widely used for treatment rheumatic diseases, including psoriatic arthritis. Adverse reactions could develop during methotrexate therapy, the most common of which are skin lesions, liver dysfunction, diarrhea, nausea, etc. Gynecomastia is a rare complication of low-dose methotrexate therapy. The mechanism of its development is not fully understood. We present a case report of the development of gynecomastia in a patient with psoriatic arthritis during treatment with methotrexate.


Xpitv u>vt7<r8at is rightly rejected, and the proposed substitute, that &OTC OV emphasizes a fact and not merely a result, states a view of this ow as old as Kriiger and now, I believe, generally adopted. The only difficulty involved is that the indicative would be more natural. At § 5 the note on 4\irls iari ftviffiai refers without comment to the unsatisfactory note in Goodwin, to which attention has lately been drawn by Mr. Lend rum. The book closes with an accurate and useful Index to both volumes. E. C. MARCHANT.


Stephen Carmichael wrote about Cryoelectron Tomography in the May 2003 issue of Microscopy Today. Citing new preparation methods, small cells can be vitrified, observed frozen in the TEM and a series of digital images captured while the specimen is being rotated around the axis perpendicular to the electron beam producing a 3-D tomogram. Gina Sosinski and Maryann Martone wrote about imaging big and messy biological structures using cryo-electron Tomography in the July issue of Microscopy Today. Cryo-HRSEM now also seeks to provide 3-D information approaching the molecular level from frozen hydrated cell and molecular systems. Vitrification procedures for small specimens such as platelets and biomolecules on grids are accomplished by plunge freezing in liquefied etiiane as is done with cryo-TEM procedures. Bulk specimens such as organic hydrogels and tissues are routinely high pressure frozen (HPF) in 3mm gold planchets. Employing an in-lens cryostage, identical to those used in cryo-TEM, cryo-HRSEM provides 3-D high-resolution images because secondary electrons are efficiently collected above the lens in a single scan thus minimizing specimen irradiation.


The design of high-safety instant-action electric blasting cap is offered. The blasting cap does
not contain any primary explosives. The blasting cap's principle of operation is based on the
deflagration-to- detonation transaction of the secondary explosive which is placed into the
confinement. The operability of the offered design is experimentally checked.


Purpose of the study: to reveal the influence of hydromorphism and agricultural use on the molecular-mass distribution (MMD) of humic (HAs) and fulvic acids (FAs) isolated from the soils of the European northeast of Russia. To assess the influence of the acidity of the medium on the MWD of FAs.
Place and time of the event. The studies were carried out on the territory of the middle taiga (Maksimovsky station of the Institute of Biology of the Federal Research Center of the KSC UB RAS, located 8 km west of the city of Syktyvkar and the field of the Syktyvkar state farm, 5 km south-west of Syktyvkar, on the watershed of the Sysola and Vazhel-yu rivers) and northern taiga (3 km west of the Troitsko-Pechorsk station). The objects of the study were humic substances isolated from typical podzolic (Eutric Albic Retisol (Loamic)), gleypodzolic (Eutric Albic Stagnic Retisol (Loamic)), peaty-podzolic surface-gleyed (Eutric Albic Stagnic Histic) Retisol (Loamic Eutric Albic Retisol (Loamic)) soils. The soil sampling period is from 1 to 30 August 2014.
Methodology. Quantitative analysis of the MMD of HA and FA preparations was performed using liquid size exclusion chromatography (gel chromatography) on Sephadex G-25 and G-100 gels with continuous automatic registration of the optical density of the eluate (λ = 280 nm) in a quartz flow cell, K 9 × 60 cm column (Pharmacia, Sweden). Distilled water, 0.05 M NaOH solution, and Tris-HCl buffer with pH = 8.2 were used as the eluent.
Main results. Studies of the MMD of humic substances have been carried out. It was found that HAs contain three fractions with different molecular weights: ≥ 150 kDa, 73–80 kDa, and 13–23 kDa; FAs – two fractions: ≥ 5 kDa, 1–2 kDa. The low molecular weight of FAs, together with a large amount of oxygen-containing functional groups, contributes to their better solubility and migration ability in soils. The HAs of automorphic soils are characterized by a high content of low molecular weight fractions, and the proportion of the high molecular weight fraction in the HAs of the litter is 1.5–2.0 times higher than in the HAs of the podzolic horizon, which may be due to the migration of the low molecular weight fraction down the profile. The high proportion of the acidic low molecular weight fraction in the podzolic horizon promotes the decomposition of soil minerals and their leaching into the illuvial horizon. The influence of agricultural use of soils on the fractional composition of humic compounds is estimated. A sharp increase in the share of the high molecular weight fraction in the preparations of HAs of arable podzolic soil by 2–4 times compared with the HAs of virgin podzolic soils was noted, which is due to the cultivation of the arable horizon, the nature of the incoming plant residues and the increased microbiological activity of the developed soils. The effect of acidity of the medium on the character of chromatograms of FA preparations isolated from the main types of soils of the Komi Republic was studied. It has been shown that in the region of high pH values of the eluent 9–13, the absence of fractionation is associated with the association of FAs, a change in their conformation, and the effect of "over-exclusion". Elution with distilled water (pH = 6.5) allows the separation of FAs into two fractions with molecular weights ≥ 5 kDa and 1–2 kDa.


Exploring a method of taming the boundary behavior of n-convex exhaustion functions, a curvature property of line bundles associated to effective Cartier divisors is proved. Cohomology vanishing theorems of the Serre type and the Kodaira-Nakano type are obtained as application.


This paper introduces random lump sum into Hoem model. Using the theory of counting process and martingale, we get the formula of state reserve and its stochastic differential equation. Therefore the Thiele's differential equation is obtained as well as the net indemnity rate of retirement from individual accounts.


e22006 Background: The aberrant expression of microRNAs has been demonstrated to play a crucial role in the initiation and progression of colorectal cancer (CRC). miR-222 is overexpressed in many t...


Objective To study the change of T lymphocyte subsets and NK cells in esophageal cancer patients and the influence after radio-chemotherapy.Methods Sixty-eight cases with histologically confirmed esophageal cancer were treated with radiotherapy alone or concurrent radiotherapy and chemotherapy,measured by flow cytometry before and after treatment of peripheral blood T lymphocyte subsets and NK cell ratio and contrasted to the healthy people.Results(1)Peripheral blood T cells in patients with esophageal cancer,Th cells,Th/Ts was compared with the control group decreased significantly,while the Ts cells were significantly increased.(2)The clinical differences of peripheral blood T lymphocyte subsets,Th/Ts ratio change with patient sex,tumor staging,histological differentiation,pathological lesions,were no significant meaning.(3)After radiotherapy and chemotherapy,the patient's peripheral blood T cells,Th cells,Th/Ts cell ratio and NK cells were increased,while the Ts cells decreased,the difference was significant.Conclusions Cellular immune function in patients with esophageal cancer is suppressed,detection of T lymphocyte subsets,NK cells can be used for immune monitoring of patients with esophageal cancer.


The complex modern day issues of energy and sustainability can be approached from several angles. Addressing such large scale issues requires not only large scale fixes, but also small scale solutions. One particularly interesting and promising area of small scale research involves residential energy use. In the United States, residential energy consumption represents 21% of total primary consumption, so reducing household energy use can make a big impact on a significant slice of consumption. One current obstacle in the way of energy reduction is that the average homeowner only sees the total electricity usage each month, and has no clear idea about which appliances are using how much energy or when. This lack of information makes it somewhat di cult for the homeowner to implement or quantify concrete energy-saving measures. Fortunately, knowledge of appliance-specific energy use has proven to e↵ectively increase user energy e ciency by up to 15%. The primary point of interest in this project, therefore, is to use machine


Several studies have conducted along the use of interactive tools in teaching English to test its effectiveness. Hence, this study used Kahoot! App as a tool in teaching English to high school students and determined its effect. It involved 30 Grade 7 students who were enrolled in English 7 during Academic Year 2021-2022. Class observations and interviews were done and it was found that students were rarely volunteering to answer questions and contribute to the discussion because of the traditional tools used by the teacher. Thus, to further validate this, the respondents were given a pretest and posttest. This was to determine whether there is a significant difference in the mean score of the respondents before and after the intervention was employed. Result of the pretest and posttest show that the mean score of the respondents in their pre-test for week 1 was 5.83 ( Fair ) and 6.33 ( Fair ) for week 2, while their posttest mean score for week 1 was 14.67 ( Very satisfactory ) and 14.60 ( Very satisfactory ) for week 2. Further, -21.70 for week 1 and -25.00 for week 2 as t-values mean that the students gained a lower score in their pre-test than their posttest. In addition, the p-value of 0.000 is less than the .01 level of significance which means that there is a significant difference of the pre-test and the post-test. This implies that the intervention of this research study proved to improve the participation of the students in English. Hence, it is strongly recommended for teachers to use Kahoot! App in their English classes to also identify its result. p-value of 0.000 is less than the .01 level of significance which means that there is a significant difference of the pre-test and the post-test. This implies that the intervention of this research study proved to improve the participation of the students in English. Thus, the intervention of this research study is highly recommended for teachers to use in facilitating assessment activities in online setting.


Abstract. We present new characteristics of the central tendency and dispersion of data samples. They are constructed from estimates of parameters of underlying distributions and make possible an easy comparison of results obtained under different assumptions.


High‐time resolution measurements of primary marine organic sea‐spray physico‐chemical properties reveal an apparent dichotomous behavior in terms of water uptake: specifically sea‐spray aerosol enriched in organic matter possesses a low hydroscopic Growth Factor (GF∼1.25) while simultaneously having a cloud condensation nucleus/condensation nuclei (CCN/CN) activation efficiency of between 83% at 0.25% supersaturation and 100% at 0.75%. In contrast, the activation efficiency of particles dominated by non‐sea‐salt (nss)‐sulfate ranged between 48–100% over supersaturation range of 0.25%–1%. Simultaneous retrieval of Cloud Droplet Number Concentration (CDNC) during primary organic aerosol plumes reveals CDNC concentrations of 350 cm−3 for organic mass concentrations 3–4 μg m−3. It is demonstrated that the retrieved high CDNCs under clean marine conditions can only be explained by organic sea‐spray and corroborates the high CCN activation efficiency associated with primary organics. It is postulated that marine hydrogels are responsible for this dichotomous behavior.


The identification of genes is an ongoing research issue in the biomedical and bioinformatics community. The Human Genome Project which was completed in 2003, identified approximately 20,000+ genes in the human DNA, but there are still many of these genes for which their function or role is unknown, and this accounts only for healthy DNA. Genetic diseases like Cancer, Alzheimer, Hemophilia and others, have mechanisms that we currently just started to understand. For instance, genes BRCA1 and BRCA2, famous for their role in breast cancer (Friedman et al., 1994), only account for 5% of the incidence of the aforementioned cancer (Oldenburg et al., 2007). Many questions rise: What are the rest of the mechanisms involved in this cancer type? Are there other genes involved? How? This only accounts for one type of cancer, and there are at least 177 different types according to the National Cancer Institute 1. The straightforward method to deal with this problem is to do wet lab experiments with large samples of normal and disease tissue, to test under different conditions the reactions, and check the expression or lack of it in different genes. The complication with this method is the cost, it takes time, it requires specialized equipment, and thus the economic price tag is high. Fortunately the bioinformatics area has acquired maturity during the recent years, biological data is becoming available in different formats throughout different databases and publications are providing new insights. Thanks to these, computational methods can be developed, methods that would save time, effort and money, methods that could help biomedical researchers get clues on which genes to explore on the wet laboratory, so that time is not wasted on genes that are unlikely to contribute in a given disease. Gene Prioritization methods can be used to find genes that were previously unknown to be related to a given disease. The general definition of gene prioritization is: Given a disease D, a candidate gene set C, and the training data T, then input all these data to the method and it will compute a score for each of the candidate genes, higher scoring genes are supposed to be the genes that are most likely related to disease D, see fig. 1. Methods can be classified according to the type of input data that the method uses, as Text and Data MiningMethods and Network Based Methods. Text and Data Mining methods use training data like genetic localisation, gene expression, phenotypic data (van Driel et al., 2003), PubMeb abstracts (Tiffin et al., 2005), spatial gene expression profiles, linkage analysis (Piro et al., 2010), gene ontology and others (Adie et al., 2005; Ashburner et al., 2000; Schlicker et al., 2010); as the name suggests this


The purpose of this community service activity is to increase the creativity of making educational game tools for parents of students' parents. This is based on several observations and found indications that most parents do not use their time well when activities wait for children to go home from school, parents only spend time without meaningful activities they usually spend just by chatting with other parents, sometimes teachers also accompany their children to learn in the classroom where these activities greatly interfere with the ongoing teaching and learning process. As a result of the routine and busyness of the parents, it is necessary to have activities that can be useful for parents and also for children's growth and development. Because in supporting the growth and development of children, educational tools are also needed that can be made by the teacher or parents themselves, so it is necessary to provide a creative training to develop educational games for parents. The method used in community service activities is in the form of counseling / education. Involved parents as much as 20. Community service activities include the provision of material on how to develop creativity to make educational games


The seismic response of structures is often enhanced by introducing passive control devices that can operate through the dissipation of the input energy or by modifying the dynamic characteristics of the main structure. The inherent non-linearities in the constitutive laws of some of them lead to computation difficulties and have limited the large-scale use and design of these devices. In this study, a procedure for the optimal design of multi passive control devices is proposed. The general case of linear Multi-Degree-Of-Freedom (MDOF) not-classically-damped structural systems controlled by Fluid Viscous Dampers (FVD) are investigated in a stochastic framework. The procedure consists of evaluation of the device optimal pattern by minimizing an objective function related to the dampers cost and subjected to a constraint on the structural behavior. For each configuration, the complete probabilistic characterization of the response is achieved by employing random vibration theory, Stochastic Linearisation (SL) techniques and a novel analytic model which provides closed-form PSD functions of earthquakes accelerations coherent to response spectra suggested by seismic codes. Exploiting this model, a procedure to speed up the Stochastic Linearisation technique by avoiding any numerical integration is proposed. Applications on MDOF building structures have been carried out to validate the proposed approach in terms of accuracy and reduction of the computational effort and to obtain optimal pattern of the passive control device coherently with the provisions of seismic building codes.


This paper presents optimization algorithms that enable multiple ship-based radar systems to maximize their collective target search area while concurrently solving an optimal sensor-to-target assignment problem. We present theoretically justified strategies that determine the optimal ship location and search-area radius for each radar in a given threat environment satisfying a pre-defined resource reserve constraint. We then solve the optimal target-assignment problem by balancing the radar tasking among all participating sensors and show the resulting increase in the number of trackable targets in the combined search area. We provide analytical and numerical simulations to illustrate the algorithm performance.


Mechanical damage to fruit is a major source of postharvest losses in many fruit including avocado. Although avocado fruit are harvested when green and hard, bruising can be a major cause of quality loss at the retailer. A study was conducted to determine the cumulative effects of handling at harvest on fruit quality after storage. A second study was carried out to characterise the relationship between drop height and fruit quality of freshly harvested fruit. Harvesting avocado fruit with an elevated work platform and passing the fruit across a commercial grader increased ripe rots after storage. Dropping freshly harvested avocado fruit from as little as 0.1m may increase the area of external bruising. This bruising may act as an infection pathway, increasing the incidence of brown patches. However, dropping from a height of up to 0.3m will lead to only minor increases in ripe rots. Empting avocado fruit from harvesting bags on elevated work platform into field bins may pose the greatest risk of exceeding the 0.3m drop height, so care is recommended to minimise the drop height when empting bags from elevated work platforms into field bins.


Based on Bank of Indonesia regulations on the valuation level of banking
performance using Risk Based Bank Rating Method SEBI No.13/24/DPNP/2011 and
the research gap that occurred differences in the results of research. This study
purposed to analyze the effect of NPL (Non-Performing Loan), LFR (Loan to
Funding Ratio), BOPO (Operating Expenses to Operating Income), CAR (Capital
Adequacy Ratio) and GCG (Good Corporate Governance) toward the level of
financial performance of banks as measured by ROA (Return on Assets). The
population that was used in this research is the Commercial Bank in Indonesia. The
samples used were 10 commercial banks in Indonesia (period 2009-2016). Research
using purposive sampling method for taking samples and analysis method that was
used is panel data regression by using software Eviews 9.0. Based on the results of
testing using data panel regression analysis, the result shown that Return On Assets
influenced by NPL, LFR, BOPO, CAR, and GCG, it based from the results of the
partial test (t-test), determination of coefficients test, and the simultaneous
significance tests (f-test). The results showed that the variables NPL, LFR, and
BOPO significantly influence the level of financial performance of banking (ROA)
but CAR , and GCG have no significant effect on the level of financial performance of
banking (ROA).
Keyword : Bank Financial Performance , Non-Performing Loan (NPL), Loan to
Funding Ratio (LFR), Operating Expenses to Operating Income (BOPO), Capital
Adequacy Ratio (CAR), Good Corporate Governance (GCG), Return on Assets
(ROA), RBBR Method

Penelitian ini bertujuan untuk menganalisis pengaruh NPL (Non-Performing
Loan), LFR (Loan to Funding Ratio), BOPO (Beban Operasional terhadap
Pendapatan Operasional), CAR (Capital Adequacy Ratio) dan GCG (Tata Kelola
Perusahaan) terhadap tingkat kinerja keuangan bank yang diukur dengan ROA
(Return on Assets). Populasi yang digunakan dalam penelitian ini adalah Bank umum
konvensional di Indonesia. Sampel yang digunakan adalah 10 bank komersial di
Indonesia periode 2009-2016. Penelitian ini menggunakan metode purposive
sampling untuk pengambilan sampel dan analisis yang digunakan adalah regresi data
panel dengan menggunakan Eviews 9.0. Berdasarkan hasil pengujian menunjukkan
bahwa ROA dipengaruhi oleh NPL, LFR, BOPO, CAR, dan GCG, hal ini didasarkan
dari hasil uji parsial (t-test), determinasi uji koefisien, dan uji signifikansi simultan (ftest). Hasil penelitian menunjukkan bahwa variabel NPL, LFR, dan BOPO
berpengaruh signifikan terhadap tingkat kinerja keuangan perbankan (ROA), namun
CAR, dan GCG tidak berpengaruh signifikan terhadap tingkat kinerja keuangan
perbankan (ROA).
Kata kunci: Kinerja Keuangan Bank, Non Performing Loan (NPL), Loan to Funding
Ratio (LFR), Biaya Operasional terhadap Pendapatan Operasional (BOPO), Capital
Adequacy Ratio (CAR), Good Corporate Governance (GCG), Return on Assets
(ROA), Metode RBBR.


Systemic Lupus erythematosus (SLE) is an autoimmune inflammatory disease of multisystem various manifestations and multifactorial etiology. Coronary artery disease remains a major cause of mortality in SLE. The cardiovascular risk factors such as hypertension and dyslipidemia are associated with coronary artery disease in SLE. Lipid disorders occur due to an imbalance between Apo A atheroprotective and B atherogenic. Some polymorphisms described for APOB gene show strong association with coronary artery disease and dyslipidemia in different pathologies. However, no studies have associated this gene polymorphism and clinical characteristics in SLE. The objective of this study is to investigate the correlation between polymorphism Insertion / Deletion of APOB gene in the occurrence of SLE in a Brazilian population. The case-control study consisted of 257 patients with SLE and the control group of 128 individuals with no description of criteria for autoimmune diseases. Whole blood samples were obtained and the clinical characteristics of patients with SLE extracted from their records. For genotyping of this region, we used the PCR-RFLP technique (restriction fragment length polymorphism -polymerase chain reaction. It was found that there was statistically significant difference in the genotype distribution between the case and control groups (P = 0.039), with genotype I / D had greater representation in the case group. the heterozygous individuals in the case group showed higher incidence of dyslipidemia, hypertension, arterial thrombosis, stroke but also discoid and photosensitivity lesions .. These results suggest association of the polymorphism studied the occurrence of SLE in the population studied.


Objective:To expand laboratory investigation of organ transplantation and prepare a model of kidney transplantation. Methods: SD rats were served as donors and recipients. Kidney transplantation was performed in 120 rats. Hypothermia infusion was conducted and prepared at prime position, donor kidney grafted at the left side. Direct vascular anastomoses and connecting the donor ureter with ureterocystic flap to the recipient's bladder were conducted. Results: The model of kidney transplantation was successfully prepared. The success rate of operation reached about 80%. Conclusion:This modified model of kidney transplantation is feasible and with a higher successful rate and can be used to study kidney transplantation further.


A series of β-amino alcohols were prepared by the reaction of eugenol epoxide with aliphatic and aromatic amine nucleophiles. The synthesized compounds were fully characterized and evaluated as potential insecticides through the assessment of their biological activity against Sf9 insect cells, compared with a commercial synthetic pesticide (chlorpyrifos, CHPY). Three derivatives bearing a terminal benzene ring, either substituted or unsubstituted, were identified as the most potent molecules, two of them displaying higher toxicity to insect cells than CHPY. In addition, the most promising molecules were able to increase the activity of serine proteases (caspases) pivotal to apoptosis and were more toxic to insect cells than human cells. Structure-based inverted virtual screening and molecular dynamics simulations demonstrate that these molecules likely target acetylcholinesterase and/or the insect odorant-binding proteins and are able to form stable complexes with these proteins. Encapsulation assays in liposomes of DMPG and DPPC/DMPG (1:1) were performed for the most active compound, and high encapsulation efficiencies were obtained. A thermosensitive formulation was achieved with the compound release being more efficient at higher temperatures.


A 19‐year‐old patient was treated for disgerminoma of the right ovary by right salpingo‐oophorectomy and pelvic radiotherapy in 1967. The left ovary was shielded after the first two treatments and the patient has since conceived three times and has shown no evidence of recurrence of the tumour.


The purpose of this study was to determine whether binaural interference would occur if ITD‐based extents of laterality were measured using high‐frequency transposed stimuli as targets. The results of an earlier study [L. R. Bernstein and C. Trahiotis, J. Acoust. Soc. Am. 116, 3062–3069 (2004)], which focused on threshold‐ITDs rather than extents of laterality, suggested that high‐frequency transposed stimuli might be immune to binaural interference effects resulting from the addition of a spectrally‐remote, low‐frequency interferer. In contrast to the earlier findings, the data from this study indicate that high‐frequency transposed targets can, indeed, be susceptible to binaural interference. High‐frequency transposed targets, even when presented along with an interferer, yielded greater extents of ITD‐based laterality than did Gaussian noise targets presented in isolation. That is, the enhanced potency of ITDs conveyed by transposed stimuli persisted even in the presence of a low‐frequency interferer. ...