ABSTRACT FROM experiments with growing turkeys, Milby et al. (1943) and Carlson et al. (1951) found that diets which contained large amounts of fiber gave good growth but resulted in poor efficiency of feed utilization. The effect of physical form of the diet was investigated by Carver et al. (1938) who found no significant difference at 28 weeks in the weights of turkeys fed mash, pellets, or mash and pellets. However, Slinger et al. (1949) and Goodeal and Moore (1941) reported that the feeding of diets in the form of pellets, as compared to mash, resulted in better weight gains and efficiency of feed utilization in growing turkeys. Energy studies with growing turkeys have not been as numerous as those with chickens. Blaylock et al. (1954) reported that turkeys consumed less corn or barley on a 963 Cal./lb. diet than on a 677 Cal./lb. diet. The existence of a relationship between . . .


In order to improve pixel count and collecting area, future transition edge sensor X-ray focal planes require pixels with both a higher coverage of the active area and compatibility with in-focal-plane multiplexing. To achieve these improvements, we have developed a pixel with an "overhanging" geometry that allows us room for multiplexing elements underneath the absorber simultaneously with the possibility of near full coverage of the focal plane. We have fabricated and tested such a pixel. We have demonstrated a spectroscopic resolution of 3.2 eV full-width at half-maximum at 5.9 keV, thereby showing that it is suitable for applications in the near future.


Introduction: Fractures are often the first sign of osteoporosis. Aim: To establish importance of previous fractures as a predictor of osteoporosis. Material and Methods: The prospective analysis encompassed 2328 patients by merging two ,,Bonlink' databases from two reference osteodensitometric centers in Serbia: one from Special Hospital for Rheumatic Diseases Novi Sad and other from Railway Healthcare Center, Belgrade. All patients had their bone mineral density (BMD) measured at the lumbar spine and at the hip. Results were interpreted according to the valid definition of osteoporosis. All patients were questioned regarding previous low-trauma fractures and/or their radiographic findings were observed from medical documentation. In statistical analysis, descriptive statistics, central tendency measures, and chi-square test were used. Results: 97% of patients were women and 3% were men, with average 64.39±8.84 years of age. According to the T score of the hip and the lumbar spine, most patients had their BMD on the osteopenia and osteoporosis level. From all subjects, 31% had low energy fractures. Regarding differences between subjects with different T score at the hip and low energy fractures X2 = 60.19; p = 0.00) and differences between subjects with different T score at the lumbar spine and low energy fractures X2 = 31.89; p = 0.00) there was statistical difference between subjects with osteopenia/osteoporosis and those with regular Tscore results regarding previous low-trauma fractures (p<0.01). Conclusion: Low energy fractures are important predictor of osteoporosis. Therefore early diagnosis of osteoporosis is of utmost importance, before the first fracture occurs.


This study, which was done to illustrate the extent to which language degeneration has reached in Giresun, stands out as a clear sample of a general language deganeration or pollution nationwide. In the study, workshop names, menues and the statements or writings on clothes in the province of Giresun were all studied. The results obtained showed an unwanted increase in the number of foreign words on signboards, clothes and food and beverage names in menues, which threatens not only our language but also our culture. A number of urgent measures should be hastily taken in order to prevent our language and culture from experiencing a more degeneration.


In the course of the work, an analysis of modern domestic and foreign paremiological studies was carried out, modern scientific trends and directions of these studies were identified. The end of the 20th century and the beginning of the 21st century was done a reproductive descriptive and analytical review of research on modern domestic and foreign paremiology. The study of proverbs in Kazakh linguistics is divided into four stages, in which the third stage develops in the areas of ethnolinguistics, comparative lingua-cultural studies, and gender linguistics. The anthropocentric study of proverbs separated them from phraseology, turned them into a separate branch of folklore science, and focused on the communicative and pragmatic potential of paremiological units. The article analyzes the main aspects of modern domestic and foreign paremiological research, clarifies the directions and prospects for the development of paremiology of the Kazakh language, focuses on the tasks of future research in this area.


In the title complex, [Ni(C7H3NO4)(C15H11N3)]·C3H7NO·H2O, the NiII ion is six-coordinated within an octahedral geometry defined by three N atoms of the 2,2′:6′,2′′-terpyridine ligand, and two O atoms and the N atom of the pyridine-2,6-dicarboxylate di-anion. In the crystal, the complex molecules are stacked in columns parallel to the a axis being connected by π–π stacking [closest inter-centroid separation between pyridyl rings = 3.669 (3) Å]. The connections between columns and solvent molecules to sustain a three-dimensional architecture are of the type water-O—H...O(carbonyl) and pyridyl-, methyl-C—H...O(carbonyl).


In this essay, I will argue that contemporary ecofeminist discourse, while potentially adequate to deal with the issue of animals, is now inadequate because it fails to give consistent conceptual place to the domination of animals as a significant aspect of the domination of nature. I will examine six answers ecofeminists could give for not including animals explicitly in ecofeminist analyses and show how a persistent patriarchal ideology regarding animals as instruments has kept the experience of animals from being fully incorporated within ecofeminism.2


While historians have acknowledged the importance of dynastic marriages to political strategy and diplomacy during the fifteenth and sixteenth centuries, little attention has been paid to how individuals were readied for such marriages by their families. The Este-Gonzaga match was a neighbourly one. The close proximity of Ferrara and Mantua and a decade-long betrothal permitted the two families to try to establish familiarity between their betrothed children in order to reap the political fruits that a harmonious marital relationship would provide. This chapter provides an insight into what contemporaries believed to be the foundations for a successful marriage and uncovers the very different journeys towards wedlock of a young, strictly cloistered, aristocratic girl and a mature bachelor prince.


Effects of artificial ultraviolet-visible light and methyl jasmonate (MJ) treatment on 'Fuji' apple (Malus sylvestris (L.) Mill. var. domestica (Borkh.) Mansf.) fruit peel anthocyanin, phenolic, carotenoid, and chlorophyll production were examined using tristimulus color analysis and reverse-phase high performance liquid chromatography. Anthocyanin synthesis was enhanced by light and MJ treatment. Chlorogenic acid and most cyanidin, quercetin, and phloretin glycosides increased with MJ treatment concentration. Light alone also promoted increased production of most of these compounds. Production of catechin, (-)epicatechin, quercetin, and quercetrin was not enhanced by either light or MJ treatment. Light and MJ enhanced s-carotene and chlorophyll b, synthesis but not xanthophyll or chlorophyll a synthesis. The chlorophyll a/b ratio decreased with MJ dosage. Results suggest MJ may provide a viable means of enhancing apple fruit coloration and other photoprotective mechanisms. Chemical name used: methyl 3-oxo-2-(2- pentenyl)cyclopentane-1-acetate (methyl jasmonate).


2-Propanol is shown to be an effective hydrogen donor, in the presence of palladium/carbon, for catalytic transfer hydrogenation reactions of benzylic and styryl compounds, e.g., for the quantitative conversion of cinnamyl alcohol into 3-phenylpropanol. In the reduction of derivatives of cinnamic acid, decarboxylation also occurs. During the latter reaction, the phenyl group appears to function as an anchoring group for the palladium atom, because derivatives of phenylpropanoic acid are decarboxylated more readily than are those of phenylacetic acid. In hydrogenolysis reactions, aryl alcohols undergo disporportionation whereas benzyl ethers, represented by O-benzyl and related derivatives of carbohydrates, are smoothly cleaved. Although 2-propanol is less reactive as a hydrogen donor than formic acid, it exhibits greater selectivity, as illustrated by relative rates of hydrogenolysis of O-benzyl and O-benzylidene substituents. The use of alumina-supported palladium is more effective than palladium/carbon ...


Two thermally activated delayed fluorescence (TADF) materials TBP-DmCz and TBP-TmCz were successfully synthesized using 1,3,5-tribenzoylbenzene (TBP) as electron-acceptor, 1,8-dimethylcarbazole (DmCz) and 1,3,6,8-tetra-methylcarbazole (TmCz) as electron-donor, respectively. Thermal gravimetric analysis show that the thermal decomposition temperatures ( T d ) are 479 ℃ for TBP-DmCz and 484 ℃ for TBP-TmCz and no glass transition was found for both materials during the differential scanning calorimetry investigations. The highest occupied molecular orbitals (HOMO) are confined on the carbazole unit, while the lowest unoccupied molecular orbitals (LUMO) are located on the 1,3,5-tribenzoylbenzene unit, and there is almost no overlap between HOMO and LUMO, which is the typical molecular orbital character of TADF materials. Meanwhile, TBP-DmCz and TBP-TmCz possess degenerated HOMO and LUMO, which would promote the radia-tive transitions as the transitions could take place from all degenerated LUMOs to HOMOs. The HOMO level of TBP-TmCz is obviously higher than that of TBP-DmCz due to increasing the number of methyl groups at the electron-donor carbazole, and the LUMO levels of TBP-DmCz and TBP-TmCz only show a small difference because these materials have the same electron-acceptor 1,3,5-tribenzoylbenzene. In toluene solution, these materials have very similar absorption spectra and ex-hibit absorption bands assigned to intramolecular charge-transfer transition. The spectral peaks are located at 488 nm for TBP-DmCz and 502 nm for TBP-TmCz, respectively, in toluene solution at room temperature. According to the fluorescence and phosphorescence spectra of these materials in 1,3-bis( N -carbazolyl)benzene (mCP) film show high efficiency and low efficiency roll-off. The maximum external quantum efficiencies of devices based on TBP-DmCz and TBP-TmCz are 13.6% and 18.3%, respectively.


In recent years,knowledge base systems became an innovative technology for the preservation and utilization of knowledge assets in Traditional Chinese Medicine(TCM) domain.This paper reviews the research progress of Traditional Chinese Medicine knowledge base system from 3 aspects such as constructing methods,coverage and applications,in order to provide useful information for researchers in TCM informatics.


have no financial interest to declare in relation to the content of this communication. Copyright © 2020Wolters Kluwer Health, Inc. All rights reserved. ISSN: 0148-7043/21/8602–0243 DOI: 10.1097/SAP.0000000000002416 FIGURE 1. A 22-year-old man had a right little fingertip amputation. The fingertip's color is pink after operation (upper left and right) The patient had smooth fingertip contour at the 3-week and 3-month follow-up (lower left and right). Annals of Plastic Surgery • Volume 86, Number 2, February 2021 Letters and Commentary


6061 Background: The tumor microenvironment provides important insights into cancer behavior and its response to treatment. In particular, the cellular composition and spatial arrangement of tumor immune infiltrates are associated with patient prognosis and survival. We optimized and employed a novel method using readily available hematoxylin and eosin (H&E) slide images, termed the G-cross score, which reflects immune cell infiltration levels and their proximity to tumor cells. The G-cross score is calculated by estimating the probability distribution of immune cells, of any type, within a certain distance from a tumor cell, with higher scores indicating greater immune cell infiltration. However, because G-cross scores are calculated from H&E slides, the method is unable to distinguish among immune cell types. Using head and neck squamous cell carcinoma (HNSCC) patients having both G-cross scores and bulk RNA-seq data, we determined which subset of tumor-infiltrating immune cell types best correlate with G-cross scores, and its predictive and prognostic value. Methods: G-cross scores were calculated for 425 HNSCC samples from University of Michigan, of which 64 had paired bulk RNA-seq data. We applied the cell-type deconvolution tool, CIBERSORTx, to identify immune cell type proportions based on RNA-seq data. G-cross scores were correlated against cell-type deconvolution results, immune cell activation expression signatures, and validated gene expression-based radiosensitivity index scores. Pearson's correlation coefficient and p-value using HPV status as a covariate in a linear model was calculated for each comparison. For survival and recurrence analysis, Cox proportional hazards multivariate regression was performed using the entire 425 sample cohort. Results: G-cross scores were significantly correlated with total T cells (R = 0.52, p = 4.63✕10-5), B cells (R = 0.33, p = 2.08✕10-2), and dendritic cells (R = 0.46, p = 7.71✕10-4), but not macrophages or mast cells. G-cross scores also had a positive correlation with T cell activation (R = 0.46, p = 2.17✕10-4) and B cell activation (R = 0.53, p = 1.24✕10-4) and were correlated with radiation sensitivity (R = -0.44, p = 6.67✕10-4). Survival analysis showed higher G-cross scores were associated with a longer time to recurrence and improved overall survival (p = 3.0✕10-4). Conclusions: G-cross scores are mainly driven by T cell and dendritic cell levels among tumor-infiltrating lymphocytes and are correlated with B and T cell activation. Importantly, G-cross scores also correlate with gene expression profiles associated with response to radiotherapy as well as time to recurrence and overall survival. G-cross scores may be an important biomarker of radiation response and indicative of protective immune subsets for HNSCC patients.


The molecular dynamics code CHARMM is a popular research tool for computational biology. An increasing number of researchers are currently looking for affordable and adequate platforms to execute CHARMM or similar codes. To address this need, we analyze the resource requirements of a CHARMM molecular dynamics simulation on PC clusters with a particle mesh Ewald (PME) treatment of long range electrostatics, and investigate the scalability of the short-range interactions and PME separately. We look at the workload characterization and the performance gain of CHARMM with different network technologies and different software infrastructures and show that the performance depends more on the software infrastructures than on the hardware components. In the present study, powerful communication systems like Myrinet deliver performance that comes close to the MPP supercomputers of the past decade, but improved scalability can also be achieved with better communication system software like SCore without the additional hardware cost. The experimental method of workload characterization presented can be easily applied to other codes. The detailed performance figures of the breakdown of the calculation into computation, communication and synchronization allow one to derive good estimates about the benefits of moving applications to novel computing platforms such as widely distributed computers (grid).


The present invention to achieve an improvement in security, to provide an easy-to-user authentication system is used. Input means for accepting an input of an address data of the portable terminal corresponding to the user owned by the user, and the one for inputting the generated response data to memory corresponding to the address data corresponding to the data generating means, receiving in input means address data in the future with also a corresponding data transmission means for transmitting the corresponding data generated in the corresponding data generating device, when the response data is input through the input means from the user, correspond with the corresponding data has already been generated by the corresponding data generating means storing It was provided with a control means for performing control of whether or not the data match. A content server, a data management server, the user interaction device, a touch panel, a display, a password generating section, content delivery, a user data storage unit


The comparison of the theoretical and experimental determinations of the anomalous magnetic moment of the muon $(g-2)_\mu$ constitutes one of the strongest tests of the Standard Model at low energies. In this article, we compute the leading hadronic contribution to $(g-2)_\mu$ using lattice QCD simulations employing Wilson quarks. Gauge field ensembles at four different lattice spacings and several values of the pion mass down to its physical value are used. We apply the O($a$) improvement programme with two discretizations of the vector current to better constrain the approach to the continuum limit. The electromagnetic current correlators are computed in the time-momentum representation. In addition, we perform auxiliary calculations of the pion form factor at timelike momenta in order to better constrain the tail of the isovector correlator and to correct its dominant finite-size effect. For the numerically dominant light-quark contribution, we have rescaled the lepton mass by the pion decay constant computed on each lattice ensemble. We perform a combined chiral and continuum extrapolation to the physical point, and our final result is $ a_\mu^{\rm hvp}=(720.0\pm12.4_{\rm stat}\,\pm9.9_{\rm syst})\cdot10^{-10}$. It contains the contributions of quark-disconnected diagrams, and the systematic error has been enlarged to account for the missing isospin-breaking effects.


The invention provides a three-freedom-degree minisize flapping-test measurement and control system. In the system, through an interface adapter, a computer is connected with three motor controllers so that three minisize motors are controlled respectively. Output ends of the minisize motors are connected with a three-dimensional flapping mechanism. An output part of the three-dimensional flapping mechanism is connected with a six-component minisize force/torque sensor. The six-component minisize force/ torque sensor is directly connected with a test wing. Each of the tail parts of the minisize motors is provided with a coder. Output ends of the coders are connected with the motor controllers. Output signals of the six-component minisize force/ torque sensor are connected with a signal conditioning box. The signal conditioning box is connected with an input end of a data acquisition card after amplifying a voltage signal acquired by the six-component minisize force/ torque sensor. An output end of the data acquisition card is connected with the computer. The three-freedom-degree minisize flapping-test measurement and control system enables the wing to realize three-dimensional combination flapping of any form. The system is simple and rapid in measurement scheme and at the same time capable of acquiring a plurality of aerodynamic-force data. The system is comparatively great in data synchronization and high in test efficiency.


Studies of structure and properties of TiN-Cu coatings with a wide interval of copper concentrations from 0,6 to 20 at. % have been carried out in- cluding its cutting action tests. The coatings were produced by the ion-plasma vacuum-arc deposition onto TT10K8B carbide cutting tool. Introduc- tion of copper into the composition of the coating results in nitride phase crystallite size reduction from 100 to 20 nm. In this case the hardness of coatings grows from 20 to 40 GPA while copper content in the coating increases up to 7–8 at. %. Further increase of copper content, which is accom- panied by nitride phase crystallite size reduction, is characterized by decrease of hardness down to 14–15 GPA concerned with the effect of soft duc- tile metal on it. The life tests of mechanical cutting by TiN-Cu coated 35KhGSA SMP steel show that the optimum composition of the coatings (TiN – 7–8 ат. % Cu) increases the durability of tools with replaceable polygonal inserts (SMP) more than 6 and 2,5 times compared with uncoated tool and TiN coated tool according to the basic technique respectively.


Air traffic flow management(ATFM)system has a strategic significance on keeping pace with the increasing of flight flow, reducing delays and making full use of air space and the ground resources. Realtime, good expandability and strong autonomy are the characteristics of multi-agent, and these characteristics meet the needs of ATFM system. In this paper, we fully take the characteristics of the three-tier ATFM system into account, actualize the entities that have autonomy, intelligence and have an important impact onthe system by agent. A structure of ATFM system based on agent technology is designed. The operational mode of the system and the structure of every subsystem agent are illuminated. Applying the multi-agent into the ATFM system can effectively enhance the system's adaptability and autonomy for dynamic environment, and reduce the complexity of design and construction of the system. And also offer a new way for the building of ATFM system.


In this paper we propose a neural network allowing a mobile robot to learn artwork appreciation. The learning is based on the social referencing approach. The robot acquires its knowledge (artificial taste) from the interaction with humans. We present and analyze specifically the visual system, its impact on the robot behavior, and at the end, we analyze the readability of our robot behavior according to visitors comments. We show that the low level spatial competition between the values associated to areas of interest in the image are important for the coherence of the robot's object evaluation and the readability of its behavior.


Aiming at the requirements of collection of real time data,the paper concludes studying situation of realizing the healthy data collection by using embedded technique in our nation,it pays much attention to meaning of synchronism of time to collection of healthy data,it proposes thought of data collection system of embedded type bridge base on GPS.


This report describes procedures which should be followed in the production of 35 mm slides. For slides manufactured from an author's drawing, it is important that the original drawing be prepared on a standard form. Alternative procedures for the production of slides of an actual scene and for the copying of photographs are described. Information on the storage and duplication of slide material is included (a).


The metabolism and excretion of aminopyrine in man were examined after oral administration. On the gas chromatogram, the extract from urine showed an unknown peak sometimes which seems to be a new metabolite. This new metabolite was identified as 4-formylaminoantipyrine by gas chromatography-mass spectrometry comparing with the synthesized authentic sample.


The metal organic chemical vapor deposition(MOCVD)of alumina films on Fe-Cr-Ni alloy was performed in nitrogen at atmospheric pressure.This paper studied the influencing factors of substrate temperature,ASB temperature and carrier gas flow on the deposition rate of Al2O3 film.The Al2O3 films were investigated by SEM and EDS.It was indicated that in the condition of 125 ℃ processing temperature,the thickness of film is 500μm and the bonding strength of film is twice as that of gradient layer(the gradient depositon of NiAl and Al2O3).


Maximum likelihood and Bayes estimators of the unknown parameters and the expected experiment times of the exponentiated Pareto model have been obtained for progressive type-II censored data with binomial removal scheme. Markov Chain Monte Carlo (MCMC) method is used to compute the Bayes estimates of the parameters of interest. The generalized entropy loss function and squared error loss function have been considered for obtaining the Bayes estimators. Comparisons are made between Bayesian and maximum likelihood (ML) estimators via Monte Carlo simulation. The proposed methodology is illustrated through real data.


Face recognition is a process of identifying a person based on facial features. It is one of the most popular and widely used biometrics technique today. However, there are challenges regarding robust, rotation-invariant, real-time face recognition systems. Few challenges can be listed as changes in illumination, rotations of the face, different head poses and occlusion etc. This study mainly consists of four parts, namely face detection from the image, feature extraction, training the neural network and recognition. Face detection algorithm is used to detect the face from the given image. The most useful and unique features of the face image are extracted in the feature extraction phase. The face area is first divided into K2 sub regions from which Local Binary Pattern (LBP) histograms are extracted and concatenated into a single feature vector which is used to train the Neural Network. In the recognition phase, face recognition is done by trained Neural Network. The system is trained and tested on Ondokuz Mayis University database.


We prove that if $X$ and $Y$ are two Gaussian fields with equivalent spectral densities, they have the same sample paths properties in any separable Banach space continuously embedded in $\mathcal{C}^0(K)$ where $K$ is a compact set of $\mathbb{R}^d$.


UN Convention against Corruption now takes effect in China, and it is necessary to make some modification so as to make it applicable in Chinese context. Due to the integrity of the objects, the Convention takes "One Package" legislative mode. There are three kinds of legislative modes for China in its realization of globalizing its anti-corruption legislation and high efficiency in law making. It is necessary to analyze the strengths and weaknesses of the modes so as to have the most adequate one for China.


The majority of distribution management functionalities rely on load profiles. Customer classification and load analysis have the largest impact on them. In this paper a novel approach for load profile generation is presented. The presented work is based on artificial neural networks: sparse autoencoders and deep belief networks in order to reveal hidden features from data sets.


The aim of this paper is to examine the arguments for adopting a rights-based approach to the analysis of the sentencing process rather than the traditional crime control and due process models developed by Packer (1968). An attempt is also made to further the theoretical debate by suggesting how Giddens's theory of structuration could fruitfully be extended to provide an appropriate theoretical context for the analysis of rights in the sentencing process.


Objective. To compare the results of abdominal sacrocolpopexy and vaginal high uterosacral vaginal vault suspension with fascial reconstruction for the uterovaginal and vault prolapse repair.


Circumvallate papillae of adult dd-mice were fixed in a mixture of tannic acid, glutaraldehyde, and paraformaldehyde, postosmicated, embedded in Epon, and observed under an electron microscope. An accumulation of globular electron-dense bodies (70-500 nm in diameter) was found in the apical cytoplasm of the three types of slender taste bud cells, and among the microvilli in the taste pores. High-resolution micrographs of these bodies revealed a lamellar structure with a period of 5 nm, which is characteristic of phospholipids. It is likely that tannic acid in the fixative reacts with the choline base of phospholipids to form an insoluble complex of lamellar bodies. In vivo, the phospholipids may be diffusely distributed throughout the apical cytoplasm and released into the taste pores, and may thus act as a surfactant to promote the solubility of sapid materials, which facilitates their adsorption to the membranes of microvilli of taste bud cells.


Aims. We characterize the molecular environment of candidate massive young stellar objects (MYSOs) signposted by methanol masers. Methods. Single pixel observations of 10 transitions of HCO + , CO and CS isotopomers were carried out, using the IRAM 30 m telescope. We studied a sample of 28 targets for which the 6.7 GHz maser emission positions are known with a sub-arcsecond accuracy. Results. The systemic velocity inferred from the optically thin lines agrees within ± 3 km s -1 with the central velocity of the maser emission for most of the sources. About 64% of the sources show line wings in one or more transitions of CO, HCO + and CS species, indicating the presence of molecular outflows. Comparison of the widths of line wings and methanol maser emission suggests that the 6.7 GHz maser line traces the environment of MYSO of various kinematic regimes. Therefore, conditions conducive for the methanol maser can exist in the inner parts of molecular clouds or circumstellar discs as well as in the outer parts associated with molecular outflows. Calculations of the physical conditions based on the CO and HCO + lines and the CS line intensity ratios refine the input parameters for maser models. Specifically, a gas number density of 7  cm -3 is sufficient for strong maser emission and a high methanol fractional abundance (>5$\times$10 -7 ) is required.


Abstract : The purpose of this contract was to study methods for improving images of space objects obtained with earth-based telescopes. The results of the four contractual tasks are presented. With regard to Task I, recommendations are given for the best intensifier/SIT combinations and relay optics for the Cloudcroft satellite imaging program. As discussed in the section on Task II, it has been concluded that the wavefront-determination-correction method of image restoration is probable not feasible if only linear, postdetection inverse- filtering techniques are used. A discussion of the telescope calibration instrumentation is also included. With regard to Task III, information is listed that allows the optimum film/f-number combination to be determined for use with the f/3 focal reducer. The design and operation of the f/3 focal reducer are discussed in the section on Task IV.


In a Keynesian mode of thinking wages become the nominal anchor for the price level because unit-labour costs in a closed economy represent the most important factor in determining the price level. The second most important driver of price level changes is the exchange rate. A positive economic regime includes nominal wage increases according to trend productivity growth as well as the target inflation rate of the central bank, discretionary monetary policy geared towards growth and anti-cyclical fiscal policy. Since the early 1990s nominal wages in the USA and the UK have followed this wage norm to a large extent. But in Germany, wages have increased below this norm or even decreased, and in Japan this effect has been even more extreme. Overall, while Japan and Germany have suffered from dysfunctional economic regimes leading to low growth, the UK and USA have managed a much more positive interaction between wage development, monetary policy and fiscal policy. Copyright The Author 2008. Published by Oxford University Press on behalf of the Cambridge Political Economy Society. All rights reserved., Oxford University Press.


The identification of Y‐chromosome material is important in females with Ullrich–Turner syndrome (UTS) due to the risk of developing gonadoblastoma or other gonadal tumors. There is controversy regarding the frequency of the Y‐chromosome‐derived material and the occurrence of gonadoblastoma in these patients. The aim of our study was to evaluate a large number of patients with UTS, followed before and during the pubertal age for the prevalence of Y‐chromosome derived material, the occurrence of gonadoblastoma, and the incidence of possible neoplastic degeneration. An unselected series of 171 patients with UTS (1–34 years old), diagnosed cytogenetically, was studied for Y‐chromosome markers (SRY and Y‐centromeric DYZ3 repeats). The follow‐up was of 2–22 years; 101 of these patients were followed during pubertal age. Y‐chromosome material was found in 14 patients (8%): 12 of these were gonadectomized (2.8–25.9 years). A gonadoblastoma was detected in four patients under 16 years of age: in two, Y‐material was detected only at molecular analysis (at conventional cytogenetic analysis, one was included in the 45,X group and one in the X + mar group) and one had also an immature teratoma and an endodermal sinus carcinoma. The prevalence of gonadoblastoma in our series of gonadectomized UTS patients with Y‐positive material was of 33.3% (4/12). Our data suggest that the age of appearance and the possibility of malignant degeneration of gonadoblastoma can occur early in life. These patients, in particular those with 45,X or a marker chromosome may benefit from molecular screening to detect the presence of Y‐chromosome material; PCR is a rapid and inexpensive technique. At the moment, laparoscopy and preventive gonadectomy performed as soon as possible remain the procedures of choice for patients with UTS, when Y‐chromosome has been identified, as we are still unable to predict a future malignant evolution of gonadoblastoma. © 2005 Wiley‐Liss, Inc.


Halitosis is a term that refers to an unpleasant or foul odor originating from oral cavity, which is mainly caused by volatile sulfur compounds (VSCs) produced by oral anaerobes such as Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola and Prevotella intermedia. General therapies, such as tooth and tongue brushing or usage of bacteriostat can hardly provide a harmless and continuous therapeutic effect on halitosis. Recent evidence has suggested the potential clinical application value of probiotics in the treatment of halitosis. In this study, Bifidobacterium lactis HN019 and Lactobacillus acidophilus NCFM were identified from four kinds of probiotics and the antimicrobial activities against pathogens related to halitosis and inhibitory effects on VSCs were investigated. The results showed that B. lactis HN019 and L. acidophilus NCFM exhibited superior bacteriostatic action against pathogens related to halitosis and showed remarkable inhibitory effect on the production and emission of VSCs. These findings suggest that B. lactis HN019 and L. acidophilus NCFM may serve as promising parts of a successful halitosis manage plan.


Contributing Authors. Preface. Acknowledgments. Chapter 1. Erythrocytes. Chapter 2. Leukocytes. Chapter 3. Hematopoietic Neoplasia. Chapter 4. Hemostasis. Chapter 5. Water, Electrolytes, and Acid Base. Chapter 6. Proteins, Lipids, and Carbohydrates. Chapter 7. Liver. Chapter 8. Digestive System. Chapter 9. Urinary System. Chapter 10. Muscle. Chapter 11. Endocrine System. Chapter 12. Cytology. Chapter 13. Generating and Interpreting Test Results: Test Validity, Quality Control, Reference Values, and Basic Epidemiology. Case Studies. Index.


For the large torque ripple of switched reluctance motors paper proposes an improved predictive current control method. The method inherits the advantages of simple logic and flexible control of traditional model predictive control and divides an electric cycle into nine sectors according to the switching reluctance motor conduction principle, including the phase change sector and single-phase conduction sector, in which the phase change sector is divided into two parts and the cost function is introduced to turn off the phase current. Different switching states and cost functions are selected according to the sectors to be selected. The new algorithm reduces the computational effort and the optimized cost function enables a better torque ripple suppression effect. A simulation model is built in Matlab/Simulink to simulate and analyze the proposed algorithm, and the conventional model predictions are compared with it. The results show that the proposed method has a better torque ripple suppression effect than the conventional model prediction.


Latent variable structural models and the partial least-squares (PLS) estimation procedure have found increased interest since being used in the context of customer satisfaction measurement. The well-known property that the estimates of the inner structure model are inconsistent implies biased estimates for finite sample sizes. A simplified version of the structural model that is used for the Swedish Customer Satisfaction Index (SCSI) system has been used to generate simulated data and to study the PLS algorithm in the presence of three inadequacies: (i) skew instead of symmetric distributions for manifest variables; (ii) multi-collinearity within blocks of manifest and between latent variables; and (iii) misspecification of the structural model (omission of regressors). The simulation results show that the PLS method is quite robust against these inadequacies. The bias that is caused by the inconsistency of PLS estimates is substantially increased only for extremely skewed distributions and for the erroneous omission of a highly relevant latent regressor variable. The estimated scores of the latent variables are always in very good agreement with the true values and seem to be unaffected by the inadequacies under investigation.


Because the standard parts are possessed in large proportion to the whole parts the establishment of standard parts library is an important way to improve the efficiency of product design.The article arounds the development of standard parts library on UG platform and discusses,the approach of UG Part Families and UG/Open which is used to establish parameters of the standard parts library.


As the number of online degree programs continues to grow, one of the greatest challenges is developing a sense of community among learners who do not convene at the same time and place. This study examined the sense of community among medical professionals in an online graduate program for healthcare professionals. We took the sample from a fully online program delivered jointly by a state university and a local children's hospital in the Midwest. We administered Rovai's Classroom Community Survey with 11 additional demographic questions. We also utilized online interviews to further explore students' understanding of sense of community. A bi-factor model was fitted to the online sense of community survey data. Using multivariate analysis of variance (MANOVA) and univariate analysis of variance (ANOVA) we identified potential group differences. The qualitative data were analyzed thematically in a recursive and iterative process. Study results suggested that a dominant factor existed: sense of community with two sub-domain factors including sense of learning and sense of connectedness. No significant differences in sense of community with regard to gender, native language, or area of medical practice were detected. However, results showed a difference in sense of community between the three courses examined. This study is the first to examine the sense of community among online medical professionals. Since our findings are in contrast to those of previous


This paper described the setup of a custom-built aerosol flow reactor, which was designed to generate large amount of secondary organic aerosols (above 10ˆ2 mg ) from different VOCs precursors using continuous flow mode. The RH, VOCs mixing ratio and VOCs/NOx condition can be controlled independently in the flow reactor. A series of offline analytical techniques was used to determine the chemical information of generated SOA including: CHNS elemental analyzer, nuclear magnetic resonance spectroscopy (NMR), ultra-performance liquid chromatography ultra-high resolution mass spectrometry (UHRMS) etc. Brief measurement results from those techniques were shown. After reading the paper, I have two major comments about the novelty and logic of this paper. Based on those comments, I recommend a major revision of this paper Major comments ïijĹ1ïijL'I was puzzled by the novelty of this continuous flow re-


In our study, we examine contagions materialising between the stock market indices of three countries in the Visegrad region – Poland, Czech Republic, Hungary – and selected developed countries – USA and Germany. The sample covers the period between 1997 and 2017, which includes a number of events that caused major financial and capital market turbulences in past decades, the effects of which are still significant on the capital markets of the Visegrad region today. We simulated the comovement of Visegrad and developed markets with a DCC procedure, and applied the Heckman selection model – a novel technique in relevant studies – to explain the volatility of the correlation and to capture collective behaviours between the markets. Our analysis of the extreme returns of regional indices reveals increasing global integration across the regional equity markets and their exposure to the oil market. The relevance of our work is confirmed by the presence of contagions – as presented within the framework of the model – between the regional indices and the S&P500 as well as the DAX index which are caused by financial and capital market shocks, while there is also evidence of a significant impact exerted by the German stock market index on the Visegrad stock indices. Periodically and as a function of market shifts, some variance can be observed in the contagion channels, and the unique properties specific to the region can be recognised.


We investigate optical solitons propagating through a nondiffracting Bessel photonic lattice. The transverse intensity pattern of the lattice can be adjusted through a shape parameter, inducing and changing an azimuthal modulation. We study how this modulation can stabilize transversal motion around a light ring of the lattice and characterize the different dynamics of motion.


Computer image enhancement of digitized radiographic and conventional photographs have taken advantage of several unique state-of-the-art developments to reveal anomalies in aerospace hardware. Signal processing of such imagery at TASC includes multi-frame averaging to increase signal-to-noise levels, applying specially-developed filters to sharpen details without sacrificing image information, and performing local contrast stretch and histogram equalization to display structure in low-contrast areas. Edge detection, normally complicated in radiographic images by low-contrast, poor spatial resolution, and noise, is performed as a post-processing operation and utilizes a difference-of-Gaussians method and a least-squares fitting procedure. With these software tools, multi-image signal processing allows for the precise measurement (to within + 0.02 inches, rms) of structural motion within a rocket motor during a static test firing as well as identifying stress conditions in turbine blades and matrix anomalies in composite materials. These and other image enhancement examples of aerospace hardware analysis are detailed in the presentation.


At The College of New Jersey, students of varying socioeconomic status (SES) and patterns of consumption — the way students decide to spend their money — face barriers to access different friend groups. Formal school organizations and informal friend groups often require costs to participate in their activities, so students who are not able and/or willing to pay for these activities are denied entry into these groups. This qualitative study examines the social forces which result in social exclusion based on class and consumption differences.


Three wind-tunnel simulations of the atmospheric boundary layer (ABL) flow in suburban country exposure were generated for length scale factors 1:400, 1:250 and 1:220 to investigate scale effects in wind-tunnel simulations of the suburban ABL, to address recommended wind characteristics for suburban exposures reported in international standards, and to test redesigned experimental hardware. Investigated parameters are mean velocity, turbulence intensity, turbulent Reynolds shear stress, integral length scale of turbulence and power spectral density of velocity fluctuations. Experimental results indicate it is possible to reproduce suburban natural winds in the wind tunnel at different length scales without significant influence of the simulation length scale on airflow characteristics. However, in the wind tunnel it was not possible to reproduce two characteristic phenomena observed in full- scale: dependence of integral length scales on reference wind velocity and a linear increase in integral length scales with height. Furthermore, in international standards there is a considerable scatter of recommended values for suburban wind characteristics. In particular, recommended integral length scales in ESDU 85020 (1985) are significantly larger than in other international standards. Truncated vortex generators applied in this study proved to be successful in part-depth suburban ABL wind-tunnel simulation that yield a novel methodology in studies on wind effects on structures and air pollution dispersion.


This study is aimed to design a virtual dinosaur interactive game system. Game artificial intelligence is used to simulate behaviors of dinosaurs and their teamwork, and fuzzy dynamic adjustment can change dinosaur behaviors according to the abilities of different players. Our system uses Kinect, Microsoft® video-based motion capture technology, to capture players' gestures and motions, and use multi-screen display to produce a wide-angle view in order to simulate visual effects of human eyesight. The study wants to create a virtual environment so players could feel as if they were in the age of dinosaurs.


A method of manufacturing a monolithic multilayer actuators, corresponding monolithic multilayer actuators, and external electrical contact for the monolithic multilayer actuators are disclosed. Slight change portion, in a certain way, away from the internal electrode and substantially parallel in the region of at least two opposing outer surfaces conventional internal electrodes are exposed, the actuator structure along the longitudinal axis of the stack It is incorporated. The slight change unit, the actuator towards the inside and / or towards the outer electrodes as soon as polarized, are exposed to a predetermined limited voltage reduced growth. Basic metallic coating and / or external contacts is embodied in the region of the minute variation of the at least actuator structure in tensile resistance or elastic manner.


It is well known than Permeability affects the performance of structure through the soil and rock pavements. Percolation of water, through the interconnected voids of soil and rock pavement, causes a number of soil and rock engineering problems such as settlement of buildings, yield of wells, seepage through and below the earth structures. In this paper, laboratory and field permeability tests, based on the principles of falling head and Lugeon test, were conducted on different boreholes in Khartoum New International Airport (KNIA), to study the correlation between the laboratory and the field permeability values. The main objective was to assess whether the field permeability values could be estimated from laboratory permeability values or any other physical properties deduced in the laboratory. The results show that there was a significant difference between the laboratory permeability measured and the field permeability values. The reason behind this discrepancy was further investigated and explained in the study. Nevertheless, there was a very good correlation between the laboratory permeability (KL), and the ratio field/laboratory permeability (Kf/KL). Also there was a good relationship between field permeability values and some parameters estimated from laboratory and field.


The invention discloses a mobile terminal, a rear cover assembly thereof and a forming method of the rear cover assembly. The rear cover assembly includes an upper decoration piece, a lower decorative piece, a left decoration piece, a right decoration piece and a rear cover. The upper decoration piece is connected with the upper ends of the left decoration piece and the right decoration piece separately. The lower decoration piece is connected with the lower ends of the left decoration piece and the right decoration piece separately. The peripheral wall of the rear cover is matched with the lower end of the upper decoration piece, the upper end of the lower decoration piece, the left side of the right decoration piece and the right side of the left decoration piece, wherein the upper decoration piece, the lower decoration piece, the left decoration piece, the right decoration piece and the rear cover are all independently processed forming pieces. According to the invention, the upper decoration piece, the lower decoration piece, the left decoration piece, the right decoration piece and the rear cover can be assembled into the rear cover assembly. When the rear cover assembly is applied to the mobile terminal, higher freedom degree is provided for integral design of the mobile terminal.


In hot-electron semiconductor devices, carrier transport extends over a wide range of conduction states, which often includes multiple satellite valleys. Electrical measurements can hardly give access to the transport processes over such a wide range without resorting to models and simulations. An alternative experimental approach however exists which is based on low-energy electron spectroscopy and provides, in a number of cases, very direct and selective information on hot-electron transport mechanisms. Recent results obtained in GaN crystals and devices by electron emission spectroscopy are discussed. Using near-band-gap photoemission, the energy position of the first satellite valley in wurtzite GaN is directly determined. By electro-emission spectroscopy, we show that the measurement of the electron spectrum emitted from a GaN p-n junction and InGaN/GaN light-emitting diodes (LEDs) under electrical injection of carriers provides a direct observation of transport processes in these devices. In particular, at high injected current density, high-energy features appear in the electro-emission spectrum of the LEDs showing that Auger electrons are being generated in the active region. These measurements allow us identifying the microscopic mechanism responsible for droop which represents a major hurdle for widespread adoption of solid-state lighting.


This paper draws on observations in abnormal psychology and evolutionary economics to develop a conceptual framework of the sociopathic organization. This framework explains certain failures in the socialization of modem firms. It is suggested that the framework be applied in exploring whether such failures are related to government regulation. Preliminary observations indicate that rather than providing for social learning, government intervention may in fact exacerbate sociopathic behavior by organizations.


We report on a non-enzymatic glucose sensor that was fabricated by growing CuO–Ag2O nanoparticles on a AgCuZn alloy substrate. The electrode material was characterized by X-ray diffraction, energy dispersive X-ray spectroscopy and scanning electron microscopy. Electrocatalytic oxidation of glucose can be performed at a potential of 0.45 V where the sensor exhibits a sensitivity as high as 3130 μA cm−2 mM−1. It also shows a wide and linear response, a fast amperometric response, a dynamic range from 0.4 μM to 3.0 mM, a detection limit of 98 nM (at S/N = 3) and a good selectivity. In addition, the function of each component in the alloy is also explained in this work. Furthermore, this non-enzymatic glucose sensor provides a significant degree of accuracy when tested on real samples.


The purpose of this reflexive action inquiry was to examine, from students' and instructor's differing perspectives, the authenticity (or lack thereof) of doctoral-level research methods instruction. The idea for this collaborative self-study emerged organically as a byproduct of a voluntary year-long research apprenticeship in which two of the authors were engaged, following coursework in both quantitative and qualitative research methods. The apprenticeship was facilitated by the third author, a faculty member and methods course instructor. The importance of cogenerative dialog as an organizing process for methodological mentoring emerged as a central finding when the three authors collaboratively examined the across-case themes common to their autobiographical statements about and reflections upon learning to "do research." The study's results show how and why cogenerative mentoring—as distinct from cogenerative work—goes beyond typical experiences in research methods courses, assistantships, and even dissertation work, and is therefore recommended for doctoral students in education.


The purpose of this paper is to consider the shifted ground that is evident in several recent publications in Old Testament Theology. While not more than a provisional judgement can be made, it is possible that a striking convergence of categories indicates a break in the long-standing stalemate in Old Testament theology. That stalemate, recently assessed by Reventlow /1/, has posed the history-of-traditions approach of von Rad over against the more systematic categories of Eichrodt. The major criticisms of these positions have been widely accepted, even though scholars have until now not made much progress beyond these two alternatives.


Background: In this study, we aimed to find diagnostic accuracy of neutrophil to lymphocyte ratio in comparison with liver function tests for the diagnosis of intrahepatic cholestasis of pregnancy and adverse fetal-maternal outcomes.Methods: NLR and aminotransferase (AST/ALT) levels in the blood samples of pregnant women with complaint of pruritus. 90 women with elevated transaminase were taken as cases and same number of women with normal aminotransferase levels taken as control. All were examined in this prospective case-control study.Results: Not only was the mean NLR elevated in the pregnant women with cholestasis when compared to the controls, but it also predicted the severity of the cholestasis. The correlation between transaminase levels and NLR was significant.Conclusions: Although TBA is still the diagnostic standard, NLR can be used as an initial screening tool due to its high specificity.


A base station apparatus that estimates whether or not each terminal device belonging to a communication cell of the present apparatus is present in an end area of the cell. The apparatus includes a reception device that receives from each terminal device, transmission power information which indicates transmission power of the terminal device; a registration device that successively registers the transmission power information with a storage device; a statistical processing device that computes a statistic used for estimating the terminal device present in the end area of the communication cell, with respect to a population which is the transmission power information stored in the storage device; a candidate extraction device that extracts candidates for the terminal device present in the end area of the communication cell, based on the statistic computed by the statistical processing device; and an estimation device that estimates the terminal device present in the end area of the communication cell from among the candidates extracted by the candidate extraction device.


The intent of this paper is to explore the application of information obtained from fully polarimetric data for land cover classiflcation. Various land cover classiflcation techniques are available in the literature, but still uncertainty exists in labeling various clusters to their own classes without using any a priori information. Therefore, the present work is focused on analyzing useful intrinsic information extracted from SAR observables obtained by various decomposition techniques. The eigenvalue decomposition and Pauli decomposition have been carried out to separate classes on the basis of their scattering mechanisms. The various classiflcation techniques (supervised: minimum distance, maximum likelihood, parallelepiped and unsupervised: Wishart) were applied in order to see possible difierences among SAR observables in terms of information that they contain and their usefulness in classifying particular land cover type. Another important issue is labeling the clusters, and this work is carried out by decision tree classiflcation that uses knowledge based approach. This classifler is implemented by scrupulous knowledge of data obtained by empirical evidence and their experimental validation. It has been demonstrated quantitatively that standard polarimetric parameters such as polarized backscatter coe-cients (linear, circular


Ameloblastoma is a tumor of odontogenic type, arising from the epithelium with fibrous stroma and enamel organ in different steps of evolution. Ameloblastoma is an odontogenic tumor that is located in the jaw region and though it is a benign entity it may be locally invasive. They are usually diagnosed between the third and fourth decades of life. Mandibula is more affected than maxilla. It arises in the molar-ramus region of mandible with a ratio of 80%. In small lesions enucleation or local resection are the appropriate treatment methods. But larger lesions need marginal resection. It has a high ratio of recurrence. In our case we report a recurrent ameloblastoma is presented. The patien was operated in a different of medicine with the diagnosis of ameloblastoma.We applied marginal resection. No recurrent was seen during the following period of three years.


Abstract During the last decade, both in politics and research methodology there has been an increased interest in listening to children's experiences and viewpoints, as separate and different from their adult carers. In the line with these interests, this article discusses how the quality of life, from a child's perspective, can be sociologically framed, and the relevance this has for people in the social work field. The article begins by clarifying the meaning of talking about quality of life from a child's perspective by reference to the concept of generational order. Next, some methodological experiences and empirical findings regarding quality of life from a child's perspective are briefly reported. This is partly because these experiences and findings by themselves are regarded as relevant for administrative practices and social work regarding children, and partly because they support and have been a source of shaping the sociological frame. Then, on the basis of these experiences and findings, and by adopting a relational social constructionist approach, the quality of life from a child's perspective is framed sociologically. Finally, based on the findings and framing of children's quality of life from a child's perspective some recommendations for social work regarding children are suggested.


PURPOSE
Evaluate the effect of a focused ultrasound transducer position and ground plane configuration on magnetic resonance image quality.

METHODS
The effect of transducer position with respect to the MRI B0 field and the radiofrequency receive coils was evaluated in a breast-specific MRgFUS system with an integrated RF phased array coil. Image signal to noise ratio was evaluated at different transducer locations. The effect of ultrasound transducer ground plane configuration was evaluated using a replica transducer with twelve ground plane configurations. All evaluations were performed at 3 Tesla.

RESULTS
Both transducer position and ground plane configuration were found to have a considerable effect on overall image SNR. A 67% increase in SNR was achieved by positioning the transducer face perpendicular to the B0 field. A 25% increase in SNR was achieved by segmenting the replica transducer ground plane from one continuous plane to 9 individual segments.

CONCLUSIONS
Advances in focused ultrasound hardware allow for integrated radiofrequency MRI coils as well as adjustable transducer positioning. The placement of the ultrasound transducer with respect to both the magnetic field and RF coils can have a considerable effect on image SNR and the resulting MR images that are used for MR guided focused ultrasound treatment planning, monitoring and assessment.


In 1984 Australia's Labor government adopted the secular Advance Australia Fair as the National Anthem. This was a step in the direction of republicanism. Previously, God Save the Queen was the anthem, which is still sometimes played at Anzac Day ceremonies before dawn and on occasions when there is a royal visitor.


Part 1 Background description and analyses: agricultural production and the factors of production economic factors institutional factors. Part 2 Promoting agricultural development: constraints on agricultural growth and development and efforts to address the constraints promoting agricultural growth and development future prospects.


PROBLEM TO BE SOLVED: To provide a surface sheet of absorbent article in which liquid moves quickly and smoothly from the surface to the absorbent body, and little liquid remains in the surface sheet to give a feeling of dryness, and which has good liquid permeability even against liquid especially such as menstrual blood having viscosity distribution, and has good skin touch feeling. SOLUTION: The surface sheet includes fiber aggregate containing thermally extensible fiber. In the fiber aggregate, linear embosses 14, 14, ..., extending in one direction (X-direction) while meandering in a wave or zigzag form exist, and projection parts 16, 19 surrounded by the linear embosses 14 are formed so as to be in a line in the X-direction. The projections 16, 19 form a mountain range structure wherein large projection parts 19 having large area and height and small projection parts 16 having relatively small area and height alternately exist in the X-direction. The mountain range structure is intermittently arranged in the Y-direction orthogonal to the X-direction. A ridge 20 continuously extending in the X-direction is formed between adjoining mountain range structures. COPYRIGHT: (C)2010,JPO&INPIT


The present invention relates to a photoelectric conversion element, the solid-state imaging device and an electronic apparatus. Solid-state imaging device having a plurality of pixels each of: a photoelectric conversion layer, a first conductivity type comprising a first organic semiconductor and a second conductivity type second organic semiconductor, there is added a first organic semiconductor and the second organic the third organic semiconductor is a semiconductor in the organic semiconductor derivative or isomer configuration; and a first electrode and a second electrode of the photoelectric conversion layer interposed therebetween.


Drought is one of the most devastating environmental disasters. Analyzing historical changes in climate extremes is critical for mitigating its adverse impacts in the future. In the present study, the spatial and temporal characteristics of the global severe droughts using Palmer Drought Intensity Index (PDSI) from 1900 to 2014 are explored. K-means clustering is implemented to partition the extreme negative PDSI values. The global extreme droughts magnitude around the world from 1950 to 1980 were less intense compared to the other decades. In 2012, the largest areas around the world, especially Canada, experienced their most severe historical droughts. Results show that the most recent extreme droughts occurred in some regions such as the North of Canada, central regions of the US, Southwest of Europe and Southeast Asia. We found that after 1980, the spatial extent of the regions that experienced extreme drought have increased substantially.


A group-assimilation theory hypothesizes that a Gestalt-like group is associated with assimilation among the parts of the group. Assimilation is an increase in the perceived or sensed similarity of 1 part to a 2nd part. Assimilation occurs for traditional parts such as color but also occurs for salience. The theory accounts for key outcomes in perception, memory, and conditioning. An important hypothesis is that traditional assimilation and salience assimilation tend to have opposing effects on identification. The traditional assimilation of a target to a 2nd part frequently impairs the target's identification. In contrast, the assimilation of a less salient target to a more salient 2nd part increases the salience of the target and thus improves the target's identification. The corresponding hypothesis that 2 groups are associated with contrast between those parts that belong to different groups is also considered.


Thalassaemia intermedia patients can suffer fatigue and exercise capacity reduction, possibly because of anaemia, deconditioning and lack of exercise‐induced haemoconcentration. We studied 21 β‐thalassaemia intermedia patients, 10 splenectomised (group A) and 11 not splenectomised (group B). Patients were evaluated by cardiopulmonary exercise test with blood sampling for haemoglobin and plasma protein measurements at rest and peak. During exercise, an isolated increase of haemoglobin suggested spleen contraction while a parallel increase of haemoglobin and proteins suggested fluid filtration through capillary wall. Groups were homogeneous for age and gender. Peak oxygen consumption (VO2) was 22·5 ± 4·4 ml/min/kg (51 ± 14%) and 24·3 ± 7·0 (53 ± 12%) in groups A and B respectively [not significant (NS)]. At rest, haemoglobin was 8·8 g/dl in both groups. Exercise‐induced increment was 0·4 ± 0·2 and 1·0 ± 0·4 g/dl (P < 0·001) for haemoglobin and 4·0 ± 3·0 and 5·0 ± 4·0 g/l (NS) for proteins, in groups A and B respectively. Anaemia was the major cause of peak VO2 reduction (1097 ± 260 ml/min). However, anaemia did not explain the entire exercise capacity reduction, suggesting the presence of muscular deconditioning. Exercise capacity is reduced in β‐thalassaemia intermedia because of anaemia and muscular deconditioning. Spleen contraction does not significantly influence exercise capacity although exercise‐induced haemoconcentration was greater in patients with spleen.


Introduction: Undiagnosed, or masked, hypertension may occur in up to a third of patients with normal clinical blood pressures. Masked hypertension could be detected by measuring left ventricular mass index (LVMI) using point-of-care ultrasound as it directly correlates with ambulatory blood pressures. This study was designed to determine how much training is needed for a novice to develop proficiency measuring LVMI. Methods: This is a pilot prospective cohort study comparing an instructed novice learner group to an expert control assessing improvement in LVMI using limited echocardiography. The scans took place at the University of South Carolina School of Medicine Ultrasound Institute. The novices were two PGY-3 family medicine residents and two medical students. Three attending physicians and one cardiology ultrasound technician served as expert ultrasonographers. Each novice completed a minimum of 30 scans on volunteers. Training utilized self-directed online modules and a group training lab involving real-time feedback from an expert while scanning volunteers. Then the novices completed individual blinded volunteer scanning with an expert proctor. The average of the three expert ultrasonographer measurements were used as the control during this study. Results: LVMI Deviation was plotted as a function of the number of scans attempted and fit to a linear regression model. According to the model, novices would need to attempt greater than 35 scans to approximate the expert's measurements. Conclusion: Our data suggest that it is possible for novices to accurately perform point-of-care ultrasound to measure LVMI after 35 supervised examinations. This is well within the reach of most practicing primary care physicians. Confirmatory studies will be required.


This research work entitled "The unconstitutionality of the Organic Law of Public Service about not being able to occupy public office, people prosecuted for sexual, or embezzlement crimes" could give me that is a subject little discussed in our country about how give a true reintegration into society in the labor and human affairs to people who have received some.
Kind of sentence for these crimes. The Constitution of the Republic of Ecuador in its Art. 66, paragraph 4, establishes the right to formal equality, material equality and non-discrimination, one of the most important constitutional rights that has managed to get along history and that is directly related to applying justice in society, and to maintain stability and harmony of the nation, being the Constitution which establishes this right, as this is the standard senior and that any treaty, code, law, etc., it is less and must relate to it, but the Art. 10 of the Organic Law on Public Service, is in conflict with the Constitution of the Republic in the enjoyment of the rights of people employment. Art. 11, paragraph 2 of the Constitution of the Republic, exhaustively prescribes that the exercise of the rights shall be governed by the following principles.
All people are equal and enjoy the same rights, duties and opportunities. No one shall be discriminated against on grounds of ethnicity, place of birth, age, sex, gender identity, cultural identity, marital status, language, religion,
5
ideology, political affiliation, criminal record, socio-economic status, immigration status, sexual orientation, health, carry HIV, disability, physical difference; or any other distinction, personal or collective, temporary or permanent, which has the purpose or effect of impairing or nullifying the recognition, enjoyment or exercise of rights. The law shall punish all forms of discrimination. Therefore the Constitution prohibits discrimination on the criminal record.


The utility model relates to a safety electronic igniting gun. The existing electronic igniting gun mostly adopts a single safety switch; only when in a 'close ' position, the safety switch can play the role of safety insurance; after ignited, if users forget to shift the safe switch to the ' close ' position, the switch plays no role; the igniting gun is easy to cause a fire when played by children and retardates. The utility model is characterized in that the inner wall of a casing is fixed with a laterally positioning rod; the upper cover of the positioning rod is provided with a safety member in an inversely convex shape; the safety member is provided with an L-shaped through slot matched with the positioning rod; the upper end of the safety member is abutted on the bottom of a press handle; the lower end is matched with a crow plate; the right side of the safety member is provided with a control assembly for controlling the movement of the safety member; the control assembly is longitudinally positioned on the inner wall of the casing. The utility model controls the action of the safety member through the control assembly; thus, the actions of the piezoelectricity and an air outlet valve can be controlled, the misoperation can be effectively prevented, and the safety performance of the igniting gun can be improved.


The modeling process of settling of concrete top parapet of soil dam reservoir of Khmelnitsky NPP and forecasting movement of individual points is considered in the article. It is proposed to analyze the results of high-precision geometric leveling in 2 stages: at first is allocated trend component using polynomial approximation and then the remaining deviations from trend curve approximating by partial Fourier series


This article explores the ideas of a key thinker of the International Working Men's Association in the 1860s and 1870s. César De Paepe, recognized by contemporaries as a major advocate of "collectivism," attempted to justify social property as the logical consequence both of mutualist justice and of economic necessity. His theories played a significant role in informing the programs of other socialists in the turbulent 1870s, and sustained the successes of the Belgian workers' party into the twentieth century. While historians focus on Marx and Bakunin or posit a break between "early" and "late" socialism, the study of De Paepe's writings in context draws attention to neglected themes in the intellectual development of modern socialism, and suggests that "utopianism" could underwrite practical politics. The article concludes by reflecting on De Paepe's significance for contemporary politics and the practice of intellectual history.


The utility model discloses an optical fiber composite electric power cable with an optical unit wrapt with fiber reinforced plastics (FRP) longitudinally, which comprises an optical unit, an insulated wire core and an extruded and wrapt outer sheath. The optical fiber composite electric power cable with the optical unit wrapt with the FRP longitudinally is characterized in that the inner side of the sheath of the optical unit is longitudinally wrapt with the FRP. In the utility model, the inner side of the sheath of the optical unit adopts the longitudinally wrapt FRP as a reinforcement component. By utilizing the FRP with superior physical and mechanical strength, optical fiber in the optical fiber composite electric power cable is effectively protected, and the performances of compression resistance, impact resistance, bending resistance and the like of the optical fiber composite electric power cable are enhanced, so that the optical fiber composite electric power cable has good performance reliability in the processes of laying, construction and use. Meanwhile, the product cost is lowered because an aramid fiber material with expensive price does not need to be used.


tained by milk and nutrient enemata. On the 12th, he could open his mouth to a slight extent ; the symptoms were more favourable, and the spasms had diminished in force and frequency. On passing the flnger into the wound I detected a loose fragment of bone and removed it. The extremity of the lower fragment was sharp or pointed and this I cut off with the saw. From this date he gradually improved and on the 20th all symptoms of tetanus had disappeared. The wound had assumed a healthy granulating appearance, and there was no trace of inflammation round it. After a stay of


John Dewey was not a philosopher of education in the now-traditional sense of a doctor of philosophy who examines educational ends, means, and controversies through the disciplinary lenses of epistemology, ethics, and political theory, or of agenda-driven schools such as existentialism, feminism, and critical theory. Rather, Dewey was both an educator and a philosopher, and he saw in each discipline reconstructive possibilities for the other, famously characterizing "philosophy . . . as the general theory of education" (1985, p. 338). Dewey wanted each discipline to overcome its tendency to alienate knowledge and theory from experience and reconstruct itself as an enterprise aimed at personal and collective well-being. That disciplinary ethos is articulated in this issue of Education and Culture by authors who, like Dewey, often work at the intersection of philosophy and education and who have considered the significance of children and childhood for both disciplines.1 Two interrelated, paradigmatic figures emerge from these essays, neither of which can be found directly in Dewey's writing, but neither of which, perhaps, would be articulated so widely or so compellingly today without him: the Child as Philosopher and the Philosopher as Child.


Case report: A 40-year-old female presented to the emergency room following an argument with her husband. She had a disturbed level of consciousness, shortness of breath, and multiple patches of skin discoloration. On examination, the patient was semi-conscious, had multiple ecchymosis, and bilaterally decreased air entry. Computed tomography showed multiple fractures. The patient was intubated and admitted to the ICU. The patient was discharged after 23 days of admission.


This article describes the evolutionary process of developing, disseminating, and implementing an evidence-based intervention model for children in conflict with the law. Stop Now And Plan (SNAP ® ), a Canadian, evidence-based gender sensitive model for young children in conflict with the law, was initiated in 1985 in response to the de- criminalization of children under 12 in Canada. This community-based model is well validated for its efficacious outcomes on reducing problem behaviours in this high-risk population, helping to shift the trajectory of criminal outcome. The article describes the lessons learned during the evaluation, implementation, and replication of SNAP ® and the resulting creation of a stringent implementation approach. Currently under the management of the Centre for Children Committing Offences (CCCO), replication sites known as SNAP ® Affiliates, enter into a formalized licensing agreement that includes assessing site readiness and theoretical philosophy, ongoing training and consultation, and an accreditation quality assurance process. This formalized approach has been adopted to ensure sites are able to deliver the highest quality of service and to replicate successful outcomes, changing life course trajectories of these high-risk children and families.


Power-to-gas is a versatile and effective form of energy storage by which electrolysis generates hydrogen. The produced hydrogen thus becomes an alternative energy vector, which can be contained within the natural gas energy infrastructure or other storage medium. By means of the rapid response of polymer electrolyte membrane electrolysers, Power-to-Gas can also use natural gas energy storage to offer auxiliary and regulatory power services of high value, as well as energy transformation. A General Algebraic Modelling Simulation illustrates the effectiveness of Power-to-Gas in offering green hydrogen while also performing Demand-Response ancillary services.


It is difficult to determine early Jewish interpretation of the text of Ezekiel owing to the scarcity of primary resources from the time of the Second Temple. There are no writings similar to the later Jewish commentaries, and citation of Ezekiel is rare. Our quest relies on extant Hebrew and Greek biblical manuscripts (MSS). This chapter proposes that a comparison of variants amongst these MSS, including intra and trans-linguistic variants should reveal theological and exegetical insights into the early Jewish communities which produced them, and into their interpretation of the restoration of Israel in Ezekiel 36-39. Our methodology is to take Masoretic texts (MT) as a starting point, then compare the three earliest. LXX texts with MT, while at the same time performing an intra-LXX comparison. The chapter examines each variant to see if there is any evidence, implicit or explicit, of early Jewish theological interpretation.Keywords: Ezekiel; Hebrew and Greek biblical manuscripts (MSS); Jewish communities; LXX texts; Masoretic texts (MT)


The present invention relates to a method for preparing self-emulsifiable, dual-component epoxy resin, comprising: step 1: epoxy resin and a chain extender are added in a reactor and a reaction is performed for 4 hours to 5 hours; and heating is stopped when an epoxy equivalent is reduced to 40% to 60% of an initial value; step 2: the temperature of the resultant obtained in step 1 is reduced to 90°C to 150°C, a solvent is added, and the temperature is kept; step 3: an acrylic monomer and/or an acrylate monomer is mixed with an initiator, and the obtained mixture is sealed and placed at room temperature for subsequent use; step 4: 100 to 300 parts of weight of the mixture obtained in step 3 are evenly added in the reactor; and step 5: the solid parts in the resultant obtained in step 4 are adjusted to 30 wt.% to 70 wt.% to obtain self-emulsifiable, dual-component epoxy resin. During the storage of the epoxy resin in the method of the present invention, a case of hydrolysis of an ester bond does not occur, and the resin has high storage performance. In addition, the method of the present invention does not need a neutralizing agent having a strong smell, which helps to improve an operation environment.


Using the consumable rods of 20 steel and 1Cr18Ni9Ti stainless steel, experimental studies of friction surfacing welding were carried out to clarify the nature of the frictional and transferring behavior of consumable metal. The macro pattern, microstructure, microhardness and components of welding deposition were examined in detail, and also the driving force of metal transferring was discussed elaborately. Results showed that a solid bonding and non dilution thick coating layer with uniform distribution of hardness could be obtained by using consumable rod friction welding deposition process. The asymmetric thermo physical property of frictional system was the driving force of metal transferring which was not from the whole rotational plane but real contact plane and transferring behavior followed the frictional rules of welding on, shearing and plowing. The welding deposition was consisted of refined microstructure and so did the HAZ.


Programming languages with sufficiently expressive type systems provide users with different means of data 'bundling'. Specifically, in dependently-typed languages such as Agda, Coq, Lean and Idris, one can choose to encode information in a record either as a parameter or a field. For example, we can speak of graphs over a particular vertex set, or speak of arbitrary graphs where the vertex set is a component. These create isomorphic types, but differ with respect to intended use. Traditionally, a library designer would make this choice (between parameters and fields); if a user wants a different variant, they are forced to build conversion utilities, as well as duplicate functionality. For a graph data type, if a library only provides a Haskell-like typeclass view of graphs over a vertex set, yet a user wishes to work with the category of graphs, they must now package a vertex set as a component in a record along with a graph over that set. We design and implement a language feature that allows both the library designer and the user to make the choice of information exposure only when necessary, and otherwise leave the distinguishing line between parameters and fields unspecified. Our language feature is currently implemented as a prototype meta-program incorporated into Agda's Emacs ecosystem, in a way that is unobtrusive to Agda users.


Background Metformin has recently been shown not to increase the risk of lactic acidosis in patients with chronic kidney disease (CKD). Thus, the criteria for metformin use in this population has expanded. However, the relationship between metformin use and clinical outcomes in CKD remains controversial. Methods This study considered data from 97,713 diabetes patients with an estimated glomerular filtration rate of <60 mL/min/1.73 m2. The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), and the secondary outcomes were all-cause mortality and incident end-stage renal disease (ESRD). Results Metformin users had a significantly higher risk of MACCE than non-users (hazard ratio [HR], 1.20; 95% confidence interval [CI], 1.14–1.26; p < 0.001). However, metformin users had a lower risk of all-cause mortality (HR, 0.78; 95% CI, 0.74–0.81; p < 0.001) and ESRD (HR, 0.44; 95% CI, 0.42–0.47; p < 0.001) during follow-up than non-users did. The relationships between metformin use and clinical outcomes remained consistent in propensity score matching analyses and subgroup analyses of patients with adequate adherence to anti-diabetes medication. Conclusion Treatment with metformin was associated with an increased risk of MACCE in patients with diabetes and CKD. However, metformin users had a lower risk of all-cause mortality and ESRD during follow-up than non-users did. Therefore, metformin needs to be carefully used in patients with CKD.


Temperate forests are a vital part of the natural environment and important for human existence. Yet, they are increasingly threatened by changing disturbance regimes, especially more severe droughts. Here, we combine Landsat and Sentinel-2 time series and use a kernel density estimation (KDE) to assess the baseline phenology of a mixed forest area in Germany. We compared this baseline to the forest's development during the drought year of 2018 and the following growing season of 2019. Our results show that parts of the examined forest were negatively impacted to an unprecedented degree. With the use of satellite remote sensing analyses and the KDE, we can assess the impact of drought on vegetation development without relying on parametric methods.


The boundary layer phenomena for Sisko-nano fluid flow is being observed with the effect of MHD and thermal radiation on a non-linear stretched surface. For developing a fundamental flow model, a boundary layer approximation is done, which represents time subservient momentum, concentration and energy equations. By taking the assistance of Compaq Visual Fortran, the fundamental equations are analysed by imposing a finite difference scheme explicitly. A stability and convergence study is also exhibited, and the ongoing investigation is found converged for Lewis number, Le >= 0.161 and Prandtl number, Pr >= 0.668. The impression of Sisko fluid parameter (A1, A2) along with diversified appropriate parameters is depicted in various flow fields. However, the developed visualisation of fluid flow is also depicted through streamlines and isotherms.


In this paper the fuzzy controller is designed for Static Synchronous Compensator (STATCOM) to enhance voltage stability. The transient stability model of a STATCOM is presented first. Then fuzzy controllers are designed for main and supplementary controllers of STATCOM. The main controller is used for regulating of AC bus voltage and the supplementary controller is designed for controlling of DC capacitor voltage. The PSCAD/EMTDC simulation program is used for simulation of test system. In this paper the STATCOM is connected to a typical two machine transmission system. This study demonstrates that STATCOM considerably improves transient stability of power system after occurring fault and load changing.


The structure is isomorphous with that of the bis(thioselenato) analog, with the Ni atom lying on a center of symmetry.


This study was aimed to elaborate the effect of atypical and typical antipsychotics chlorpromazin (5,10, 30 mg/kg ), haloperidol (l, 4, 10 mg/kg) clozapin (10,15, 20 mg/kg) and risperidon (1,4, 8 mg/kg) in reducing morphine withdrawal syndromes. Body weight loss during morphine pre treatment, diarrhea incidence, abdominal constriction and wet dog shakes was not prevented by all antipsychotics. Clozapin (10, 20 mg/Kg), risperidon (1,4 mg/kg), chlorpromazin (10, 30 mg/kg) could decrease swallowing movement. Exept clozapin 20 mg/kg all antipsychotics attenuated erection incidence. Risperidone (1,4,8 mg/kg) and chlorpromazine 30 mg/kg significantly attenuate `attempt to escape behaviour. Body weight loss during morphine withdrawal that measured one hour after naloxone injection.was prevented by both typical and atypical except chlorpromazine 5 mg/kg and haloperidol (1,4 mg/kg) and they both could decrease morphine withdrawal syndrom score according Gellertz Holtzman withdrawal rating score. In conclusion, both class of the antipsychotics reduced some of morphine withdrawal signs such as; erection, swallowing movement, and weight loss. Total Gellertz Holtzman rating score decreased to the range of 33,3% - 61,1 %. In addition, (RIS) risperidone reduced hyperlocomotion better than other antipsychotics used in this study, where as (CLO) Clozapin and (CPZ) chlorpromazine resulted in better response in reducing wet dog shakes effect than haloperidol (HAL) and risperidone (RIS).


The solution of real-time sensor data processing problems with multi-microprocessor architectures of the multiple instruction multiple data stream (MIMD) class is limited by the structure of the interconnection network. A class of real-time sensor processing problems is analyzed to identify required network structures for use in evaluation of candidate interconnection networks. Several fundamental interconnection patterns are identified--macropipeline, K-nearest neighbors, binary search tree, one-n, n-one, one-n with groups of i, and random connection. A general model for a multi-microprocessor testbed is presented, and three candidate interconnection networks--ring, crossbar, and cube--are described for realizing the fundamental structures. Measures are identified for evaluating the candidate networks, and current results of the evaluation are presented.


Background: The Revised International Prognostic Scoring System (IPSS-R) classifies pts with MDS into risk categories, from very low-risk (vLR) to very high-risk (vHR), which guide treatment (tx) options. Pts with intermediate-risk MDS (IR-MDS) are heterogenous and real-world tx practices and outcomes for these pts are unknown. In Spain, the GESMD is an MDS registry containing more than 16,000 pts registered from 142 study sites which represent the country. We evaluated the real-world tx patterns and survival outcomes of pts with MDS from this registry across IPSS-R risk groups (with a focus on IR-MDS) and explored factors driving tx decisions among pts with IR-MDS.
 Methods: We analyzed the data collected by the GESMD registry from January 2008 to June 2020. Pts included were adults diagnosed with MDS, with informed consent and ≥6-mo follow up if the pt was alive. Pts who did not have available data on their MDS risk score or their use of hypomethylating agent for MDS were excluded. Prior to inclusion in the registry, a curation process was performed to ensure that each pt had the minimum data set and to avoid duplication and errors. Data queries were responded to by physicians at study sites, and the final data included were reviewed by the investigators. Descriptive statistics were used to summarize demographics, clinical, and tx characteristics overall and by risk groups. Overall survival (OS) was analyzed by risk group and tx type using the Kaplan-Meier estimator and 95% confidence intervals (CIs) were calculated. In pts with IR-MDS, a number of baseline variables (including sex, diagnosis year, transfusion status, risk score, age, and blood and blast counts) were explored to assess their relationship with tx selection between either azacitidine (AZA) or best supportive care (BSC) only (eg, transfusions, growth factors).
 Results: In total, 4,604 pts were included in this analysis. The median age of enrolled pts was 76 y and 39% were female. Other baseline characteristics are seen in Table 1. Seven hundred sixty-one pts (16.5%) were classified as IR-MDS with similar distribution across IPSS-R risk score subgroups 3.5, 4.0, and 4.5. Txs received by pts in the cohort included AZA, chemotherapy, allogeneic stem cell transplant (alloSCT), BSC, and others (eg, immunosuppressors, androgens; Table 2). The majority of pts with IR-MDS were treated with BSC (61%) and AZA (38%). The median time from diagnosis to start of AZA tx ranged from 1 mo in pts with high-risk (HR) and vHR-MDS to 26 mo in pts with vLR-MDS; pts with IR-MDS started AZA at a median of 3 mo from diagnosis. Survival analysis by IPSS-R group shows that median OS decreased with increased risk score (vLR: 81.3 mo [95% CI, 73.6-89.0], low-risk (LR): 59.0 mo [95% CI, 55.2- 62.8], IR: 29.4 mo [95% CI, 27.0-31.8], HR: 15.2 mo [95% CI, 13.3-17.1], vHR: 9.4 mo [95% CI, 7.7-11.1]). When analyzed by tx type, pts with IR-MDS had longer median OS when treated with AZA or chemotherapy ± alloSCT than with BSC (AZA: 30.1 mo [95% CI, 27.3-32.9], chemotherapy ± alloSCT: 30.1 mo [95% CI, 23.8-36.4], BSC: 24.6 mo [95% CI, 18.5-30.7]; Figure 1). No relevant factors associated with decision to treat pts with IR-MDS with AZA or BSC were identified.
 Conclusions: This study shows that more than one-third of pts with IR-MDS were treated with AZA shortly after their diagnosis, similar to the HR/vHR group. This cohort represents what we know about MDS and its distribution by risk group, while bringing new information on the use of AZA and its potential value in improving the OS of pts with IR-MDS. It is possible that other factors not included in the analysis (comorbidities, distance to the hospital, social and familial support) might have had an influence on the decision to treat pts with IR-MDS with AZA or offer BSC instead. Selection bias, misclassification, and confounding might occur when using registry data and this may limit the interpretation; however, the study shows important insights into the use of real-world therapies for pts with MDS, especially IR-MDS. The COVID-19 pandemic had an impact on the study, delaying the availability and curation process of data from recent years. Analysis of length of AZA tx in relation to response to tx is ongoing.
 Figure 1 Figure 1.

 Diez-Campelo: BMS: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Takeda Oncology: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau. Sasse: Novartis: Current Employment, Current holder of stock options in a privately-held company. Wormser: Roche: Current equity holder in publicly-traded company; Novartis: Current Employment, Current equity holder in publicly-traded company. Hernandez Donoso: Novartis: Current Employment, Current holder of stock options in a privately-held company. Colicino: Novartis: Current Employment, Current holder of stock options in a privately-held company. Tormo: Astellas, Novartis, Jazz, Pfizer, Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Sanz: Gilead Sciences: Other: Travel, accommodations, and expenses; Takeda: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Travel, accommodations, and expenses, Speakers Bureau; Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Boehringer Ingelheim: Consultancy, Membership on an entity's Board of Directors or advisory committees; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees; Roche: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Travel, accommodations, and expenses; Janssen: Consultancy, Membership on an entity's Board of Directors or advisory committees; Helsinn Healthcare: Consultancy, Membership on an entity's Board of Directors or advisory committees; Abbvie: Consultancy, Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Travel, accommodations, and expenses, Research Funding. Díaz-Beyá: Celgene: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Astellas: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Jazz: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Jerez: Novartis: Consultancy; BMS: Consultancy; GILEAD: Research Funding. Valcárcel: Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Sobi: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Sanofi: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Pfizzer: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; MSD: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Jazz: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Jansen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene/BMS: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Astellas: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau.

 Sabatolimab is a novel immuno-myeloid therapy targeting TIM-3 and is under investigation for the treatment of patients with myeloid malignancies


Image recording method of the present invention com prises the steps of forming electrostatic latent image on a latent image carrier by a latent image forming means, developing the formed electrostatic latent image with toner, and transferring the visualized toner image to a transfer material after repeating at least the developing step plural times, wherein double-element developer formed from mixing toner and magnetic carrier with its density of 4.0 g/cm3 or less is used in at least the second and the succeeding developing steps among the plural times of the developing steps.