In this work, Analog-to-Digital Converters (ADCs) based on a Voltage-Controlled Oscillator (VCO) were analyzed on distortion performance. It is widely known that the performance of these ADCs is limited by the VCO nonlinearity. Since this is the most limiting factor, this MSc project was focused on the linearity of VCOs, at which a distinction was made between static distortion and dynamic distortion. The static distortion was determined from the actual (nonlinear) VCO control characteristic, that was obtained by simulations at several fixed (static) input voltages. The dynamic distortion was determined from frequency spectra with a sinusoidal input voltage to indicate frequency dependent distortion. In order to cancel the VCO nonlinearity by digital calibration, the frequency dependent distortion also known as memory effects, should be lower than 0.1 dB to gain 40 dB in performance.


Stability is a crucial issue to consider for control system design. In this paper a new multi-objective approach to approximate the stabilizing region for linear control systems is proposed. The design method comprises two stages. In the first stage, a bi-objective sub-problem is solved: the algorithm aims to calculate the vertices that maximize both the volume of the decision space and the percent of stable individuals generated within the decision space. In the second stage, the information gathered during the first stage is used to solve the actual multi-objective control design problem. To evaluate the proposed method a PID design problem is considered. Results show that in this case, our method is able to find better Pareto approximations than the classical approach.


Women's health pioneer Dr. May Cohen will join other luminaries in the Canadian Medical Hall of Fame at a [ceremony on Apr. 14][1].

Cohen entered medicine at a time when less than 10% of graduating physicians were female and textbook medical research was based on a 70 kg male body.

She went on


PurposeThe purpose of this paper is to examine how individuals' personal information organization reflects their social environments in order to understand social aspects of personal information organization.Design/methodology/approachBy using a cognitive sociological approach and based on the personal information organization process (PIOP) model (Oh, 2019), this study investigates the social aspects of personal information organization by analyzing the pre-diary interview, a diary, and two post-diary interviews conducted with each of the 18 information users in social science academic environments.FindingsSocial dimensions of personal information organization were found in differences between organizing academic and non-academic files, the way participants identified and made distinctions among files, common folders they created, and with the impact of participants' professional age on personal information organization. This study shows that information organization is a process of construction and that the participants' social foundations are reflected in the way they view and organize their files.Originality/valueThis study makes a unique contribution to the field by explaining the social aspects of personal information organization. The findings of this study deepen our knowledge of personal information organization by providing different ways to understand how and why people organize their files in certain ways, and by showing that this is not just individual behavior. In practice, this study provides insight into the design of applications and tools that support personal information management of people in specific social environments.


Energy saving bulbs are promoted for their efficiency and capacity to reduce the emission of greenhouse gases, the acknowledged cause of global warming and climate change. They however contain varying quantity of mercury that can easily contaminate the environment. Mercury is a neuro-toxin, but damage has also been reported in the kidney, skin and the cardiovascular system. There is therefore an urgent need to emphasize the safe disposal of the energy-saving bulbs as their use increase in Nigeria. Recycling programme should be institutionalized, with the active participation of the manufacturers and importers of the bulbs; while education programme should be mounted on the handling and safe disposal of broken bulbs. Keywords: Energy Saving Bulbs; Mecury Contamination; Environmental Threat


The purpose of this article is to present predictive models of dilation and shear stress of rock discontinuities by applying the neuro-fuzzy technique, which uses a) the high capacity of artificial neural networks (ANN) to understand and to model complex multivariate phenomena, and b) the concepts of fuzzy sets theory to consider the variability of the input parameters in the proposed models' responses. To develop the proposed models, experimental results were obtained from large-scale direct shear tests performed on different types of rock discontinuities and boundary conditions. The input variables of the proposed neuro-fuzzy models are the normal boundary stiffness, the ratio of fill thickness to asperity height, the initial normal stress, the joint roughness coefficient, the uniaxial compressive strength of the intact rock, the basic friction angle of the intact rock, the friction angle of the infill, and the shear displacement. The proposed models for dilation and shear stress provided results that fitted satisfactorily the experimental data, and the analyses of their performances indicated that they can represent the influence of the input variables on the shear behavior parameters of the rock discontinuities. The results from the neuro-fuzzy systems developed are also closer to the experimental data than those estimated by using traditional analytical methodologies existing in Rock Mechanics. This occurs because once considering the uncertainty of the input data, a more representative shear behavior prediction can be made by the neuro-fuzzy models.


The problem of when a given sequence (resp. two sequences) of complex points can be the zero-sequence(s) of a solution (resp. of two linearly independent solutions) of f00 + A(z)f = 0, where A(z) is entire, has been studied by several authors during the last two decades. However, it is not well-known that problems of this type were first stated and studied by O. Boruvka and V. ˇ (16) almost fifty years ago. A historical review to these studies will be given below. We then oer some remarks and improvements on results due to S. Bank and A. Sauer found in (1) and (15). Our reasoning towards these improvements is based on some growth estimates for Mittag-Leer-type series in the complex plane. These estimates might be of independent interest.


Chromosomal microarray analysis (CMA)6 has rapidly transitioned from the research setting to the clinical diagnostic setting, owing to its high sensitivity, specificity, and reliability, and by proving to be a substantial improvement over conventional cytogenetic analysis (e.g., karyotyping). Within 3 years, CMA has moved from replacing the "stepwise approach of multiple FISH studies in patients with unclear etiologies" and "an adjunct to conventional cytogenetics" (1) to "the first tier test for patients with developmental delay/intellectual disability, multiple congenital anomalies and/or autism spectrum disorders" (2). CMA has had a high impact in clinical diagnostics, leading to the discovery of new genomic disorders, and has become an indispensable tool for routine molecular and cytogenetic testing. Nonetheless, our understanding of all the nuances that influence the performance characteristics of CMA is incomplete, as was illustrated in a recent report in Nature Biotechnology that assessed performance across platforms and algorithms (3). G-banding karyotyping, the dominant form of conventional cytogenetic analysis, uniformly interrogates the entire genome at once. In contrast, CMA involves the use of several different types of microarrays and interrogates the entire genome by selectively sampling genomic loci with specific probes. Differences in probe type, probe location, and probe density (interprobe spacing) exist among array platforms. The Nature Biotechnology report provides the most comprehensive cross-platform comparison and uncovers important clinical implications for the applications of CMA, particularly with respect to array design and copy number variation (CNV) detection.

There are 2 basic array types—one that originated from the comparative genomic hybridization (CGH) technique and the other from the single-nucleotide polymorphism (SNP) genotyping array. Both array platforms have undergone a series of rapid improvements. For example, Agilent CGH arrays evolved from 44K arrays (44 000 probes on the array) to 105K arrays, and then to 180K, 244K, and 1000K arrays (1 000 000 …


Purpose: The aim of this study was to understand the determinants of health-related quality of life (HRQOL) according to age groups in vulnerable elderly women. Methods: We conducted a cross-sectional study with 1,533 elderly women beneficiaries of the visiting health care program in Seoul. The participants were divided into three age groups: the young-old (n=753, 65-74 years), old-old (n=602, 75-84 years), and oldest-old (n=178, 85 years or older) groups. HRQOL was measured using the SF-8 questionnaire. Results: HRQOL was found to be worse in the oldest-old group (p=.007). Factors associated with HRQOL differ by age groups. In the young-old and old-old groups, higher HRQOL showed significant correlation with a higher level of self-rated health (SRH) and a lower level of depression, instrumental activities of daily living (IADL) dependence, and the number of chronic diseases. In addition, higher HRQOL was observed for elderly living alone than for those living with family. In the oldest group, higher HRQOL showed significant correlation with a lower level of depression, activities of daily living (ADL) dependence, and a higher level of SRH. Conclusions: In age specific groups, lower levels of HRQOL were observed for the oldest-old group than for the other age groups. Age group-specific nursing strategies may be required for improving HRQOL levels of vulnerable elderly women.


Abstract : This paper uses KAM torus theory and Simplified General Perturbations 4 (SGP4) orbit prediction techniques compiled by Dr. William Wiesel and compares it to Analytical Graphics Incorporated (AGI)Satellite Toolkit (STK) orbit data. The goal of this paper is to verify KAM torus theory can be used to describe and propagate an Earth satellite orbit with similar accuracy to existing general perturbation techniques. Using SGP4 code including only truncated geopotential effects, KAM torus generating code, and other utilities were used to describe a particular satellite orbit as a torus and then propagate the satellite using traditional and KAM torus techniques. These results were compared with similar data generated from initial conditions in STK. Comparisons show orbit prediction for this particular satellite can be made with low kilometer level accuracy. It is claimed with increased mathematical precision and orbital model detail, KAM torus theory applied to orbit prediction techniques can produce more accurate results than currently achievable.


We present a low cost acquisition setup for the accurate reconstruction of feet and shoe lasts geometry. It is based on the use of a single close range depth sensor (Primesense Carmine 1.09) that is moved around the object using a PC-controlled mobile robot. The mobile robot is built using a simple electric car constrained to move in a circular guide and controlled by an Arduino Uno board allowing the custom software to control the engine's speed. In the acquisition phase multiple point clouds are captured and registered in a common reference frame. The vehicle trajectory has been designed to maximize the reconstruction accuracy and robustness against changes in the scene illumination. Registered point clouds are filtered in order to remove the floor, reduce the noise and refine the alignment, and are finally merged in an unique simplified cloud that can be triangulated with standard techniques. The resulting foot model is then aligned in a standard way and segmented identifying relevant landmarks for measurement.


To the Editor:— Many complications of percutaneous renal biopsy have been reported since Inversen and Brun 1 established its clinical application and relative safety in 1951. These include perirenal hematomata, ureteral colic, renal arteriovenous fistula, intercostal arteriovenous fistula, infection, and laceration of a massively enlarged spleen, Brun and Raaschou 2 reported the case of a patient who died following renal biopsy in whom a 1-cm hematoma was found at necropsy in the wall of the gallbladder. Kerr 3 reported a fragment of duodenum along with a renal-biopsy specimen. Some of these complications have lead to shock, anuria, and death. Only one previous report of an adrenal-gland biopsy occurring as a complication of an attempted percutaneous renal biopsy could be found. This was by Kologlu 4 in 1961 from the University of Ankara, Turkey. The zona fasciculata of the adrenal gland was demonstrated by microscopic examination in his case. The present


The main purpose of the research was to develop an Automatic Weather Station (AWS) data logger using microcontroller Netduino. It will be useful to each sector which affected by weather. This research implement a telemetry system on Netduino logger in purpose to place it on remote area application, beside the study was developed a switching channel method to expand the number of I/O analog pin on Netduino. A correction factor resulted by data analysis during calibration and validation using linear regression method was "0.8594x + 4.7486" with R 2 = 0.9367. This research conclude that processing analog signal on Netduino has an alteration between its real value even not significantly, some treatment has implemented to reduce the error of data output, with using good power resource and moving averaging on each data reads (FAH).


Plasmonic heating effect on photoexcitation of gold nanoparticles (NPs) and nanostructures (NSs) finds wide application to various fields: drug delivery, cancer therapy and vapor bubble generation.1 Here we show our attempts to nanoscale fabrication and structuring. First, we describe nanohole fabrication on glass substrates.2 Au nanospheres supported on borosilicate or quartz glass substrate were illuminated with a focued laser beam with a wavelength of 488 nm, which excited both the interband and the localized surface plasmon resonance (LSPR) band of Au NP (Fig. 1). We observed immediate embedding of Au NPs, which was monitored in situ with the white light scattering spectral red-shifts of LSPR. Postmortem scanning electron microscopy (SEM) images exhibited the nanoholes fabricated together with Au NPs embedded (Fig. 2). The shapes of the nanoholes coincided with those of NPs: spherical particles gave spherical nanoholes (b-d) while triangle particles gave triangle-shaped nanoholes (e). More details will be given on site. Second, we show optothermal trapping when a single Au NP was optically heated in poly(N-isopropylacrylamide) (PNIPAM) solution.3 PNIPAM is known for its thermoresponsive nature: coil-to-globule phase transition occurs at temperatures above 32C (305 K). The random coil form is hydrophilic but globule form is hydrophobic, resulting in aggregation at T > 305 K. With laser heating of a single Au NP, we observed remarkable LSPR red-shifts ascribable to the formation of phase separated PNIPAM shell around the NP (Fig. 3). This can be regarded as optothermal trapping of PMIPAM in hot area created around the NP. Greater red-shifts were observed with increasing laser intensities. We will show the detail in the conference.


I propose a new solution concept—behavioral equilibrium—to study environments with players who are naive, in the sense that they fail to account for the informational content of other players' actions. I apply the framework to certain adverse selection settings and show that, contrary to the existing literature, the adverse selection problem is exacerbated when naive players fail to account for selection. More generally, the main distinguishing feature of the framework is that, in equilibrium, beliefs about both fundamentals and strategies are jointly restricted. Consequently, whether a behavioral bias may arise or not is determined endogenously in equilibrium. (JEL C70, D82, D83)


e14623Background: Poly-gamma-glutamic acid (γ-PGA), as a signaling regulator of Toll-like receptor 4 (TLR4), has been shown to induce innate immune responses. In previous non-clinical study, we showed that γ-PGA induces signaling pathway of Type 1 interferon, which consequently eliminates various viruses such as SARS, hepatitis C virus, influenza virus, etc. To evaluate the clinical efficacy of γ-PGA, we've investigated the antiviral effect of γ-PGA on human. In retrospective study to evaluate, the clinical significance of g-PGA treatment for vaginal intraepithelial neoplasia (VAIN), γ-PGA may be helpful for the cytological regression and reduction of viral load in patients with high-risk HPV-positive VAIN. Since previous human studies showed the possibility of a drug, we have completed a phase I dose escalation study to determine the safety, tolerance and pharmacokinetics of γ-PGA in healthy adult male subjects. Methods: In the current study, we designed a human study of γ-PGA orally treated daily (75 mL...


This article compares two television formats – one English and one French – to determine ways in which they incorporate public participation via electronic media. These new formats constitute a "demotic turn" (Turner, 2010), rather than democratisation in the true sense of the term. Using both an ethnographic and an analytical approach, we examine the hypothesis that the televised debate programme Mots Croises, traditionally designed as a debate between "experts", continues to present a hierarchy of speakers in the way it deploys electronic participation. The spectacular use to which the organisers of Mots croises put Twitter, and the splintering of opinions which results from it, emerges clearly when contrasted with the British programme Question Time, where public participation via electronic media is broadcast on a separate channel. This separation between the programme's two publics makes it possible to include a freer and more rebellious public, but at the cost of a total split between the electronic messages and the conduct of the debate in the programme.


In anticipation of Government regulations on the emission of nitrogen oxides from T. E. Holladay industrial gas turbine engines, United Technologies Corporation has tested a burner Assistant Project Engineer for the FT4 engine which meets the proposed regulation of 75 PPMV NOx at 15 Mem. ASME percent oxygen and 25 percent thermal efficiency. The design is based on predicted values of NOx as a function of flame temperature and verified the predictions. A Pratt & Whitney Aircraft Group, two-phase combustion system is employed to provide the fuel-air ratio range West Palm Beach, Fla. required for engine operation without exceeding high flame temperature or lean flammability limits. A cast, finned construction is employed for durability and low cost. Current market economic considerations have required the program to be suspended.


In this paper, a novel image denoising algorithm named fractional integral image denoising algorithm (FIIDA) is proposed, which based on fractional calculus Riemann-Liouville definition. The structures of n*n fractional integral masks of this algorithm on the directions of 135 degrees, 90 degrees, 45 degrees, 0 degrees, 180 degrees, 315 degrees, 270 degrees and 225 degrees are constructed and discussed. The denoising performance of FIIDA is measured using experiments according to subjective and objective standards of visual perception and PSNR values. The simulation results show that the FIIDA's performance is prior to the Gaussian smoothing filter, especially when the noise standard deviation is less than 30.


Let G=(V,E) be a simple graph.  A surjective function is said to be a 1-Near Mean Cordial labeling if for each edge uv, the induced map = 0  if is  an integer 1        Otherwise Satisfies the condition  where  is the number of edges with 0 label and  is the number of edges with 1 label. G is said to be 1-Near Mean Cordial Graph if it has a 1-Near Mean Cordial Labeling.  In this paper we proved that Wheel Graph , Globe Graph , Binary Trees , Odd cycle  with  a chord  are 1-Near Mean Cordial Graphs.


Fluorine occurs in living organisms in 2 forms, always associated with P. In epidermal tissues, nails, hair, and other tissues by which it is finally eliminated, the proportion of F to P is about the same as in apatite. In cells of glands, muscles, and nerves the proportion of F to P sinks 1 to 400. In artificial media of known F content, F in most cases favored the growth, flowering and seed production of plants, especially of Sinapsis. In exceptional cases such as corn, rye and oats, its influence remains doubtful. In rare cases it was found harmful.


One component of polarization-dependent gain (PDG) in optical amplifiers has been shown to originate from polarization hole burning (PHB) in the erbium fibers.1 In this paper we quantify its magnitude for copumped amplifiers under operating conditions typical of those used in long-haul amplified systems. We find that PDG can be significant, even when the polarization state of the signal is circular, and that hole burning due to the polarization of the 1480-nm pump laser contributes significantly to the overall polarization-dependent gain of the fiber.


Many real-world domains are inherently relational and temporal—they consist of heterogeneous entities that interact with each other over time. Effective reasoning about causality in such domains requires representations that explicitly model relational and temporal dependence. In this work, we provide a formalization of temporal relational models. We define temporal extensions to abstract ground graphs—a lifted representation that abstracts paths of dependence over all possible ground graphs. Temporal abstract ground graphs enable a sound and complete method for answering d-separation queries on temporal relational models. These methods provide the foundation for a constraint-based algorithm, TRCD, that learns causal models from temporal relational data. We provide experimental evidence that demonstrates the need to explicitly represent time when inferring causal dependence. We also demonstrate the expressive gain of TRCD compared to earlier algorithms that do not explicitly represent time.


This paper is set in the context of the increased prevalence of environmental direct action in the United Kingdom. After delimiting 'radical' enviromentalism, and briefly describing the impetus for this turn to direct action, I focus on the radical environmental movement's use of different media. Thus parallel to the increase in direct action has been the emergence of a variety of radical environmental news texts (in both video and print form). These texts carry different representations and cultural–political mappings of the rural and rurality. Three themes of such a depiction are described: the rural as 'nature's refuge', as a local space but potentially global in its consequence, and a space of a radical history of Englishness. In the second half of the paper I draw insight from actor–network theory to argue for a relational–materialist approach to the production and consumption of these texts. By taking this approach I describe a 'moment' wherein it becomes difficult and problematic to separate these two processes. The notion of chains of production–consumption is suggested in order to overcome this difficulty.


A drawn PET yarn was heat set (annealed) at temperatures between 110°C and 245°C in an unconstrained mode and the samples characterized by dynamic mechanical analysis (DMA). A method for estimating the fiber orientation factor (α) is proposed using DMA and shown to be more sensitive than the crystalline orientation (x-ray diffraction) or total orientation (birefringence) measurements of the heat set yarns. The extension/shrinkage behavior of the heat set yarns has been discussed in the light of morphological changes, e.g., degree of orientation and the micro-crystallite formation. Unlike in the unconstrained mode, heat setting under constraint does not lead to the formation of micro-crystallites as revealed by differential scanning calorimetry. As a consequence, although the modulus and degree of orientation increase upon constrained annealing, the thermal stability, i.e., loss of orientation (reflected by shrinkage) could not be improved.


Four yearling Angus steers fitted with permanent abomasal fistulas were used in a 4 × 4 latin square experimental design to measure relative sorghum grain carbohydrate digestion in different segments of the digestive tract, and to study the effects of various methods of grain processing on starch utilization in the rumen and/or postruminal digestive tract. Processing methods studied were: dry-ground, steam-flaked, reconstituted-ground and micronized. The location of maximum starch digestion varied with processing method. Total starch digestibility was significantly improved (P .05)


This follow-up case to UVA-OB-0412 describes the decision of the management team in charge of testing Live for Life to implement the program throughout J&J, presents further evidence regarding the effectiveness of Live for Life, and discusses the establishment of J&J Health Management, Inc., which marketed Live for Life to other companies.


Type of funding sources: None.
 Obesity and overweight play a key role in the development of cardiovascular disease or myocardial ischemia, particularly today, as does their relationship to traditional and non-traditional risk factors. Despite, diet and weight management are grossly under-met per desired body mass index (BMI) threshold goals among very high-risk patients with established atherosclerotic cardiovascular disease (ASCVD). Thus, we aimed to investigate the presence of overweight and obesity in patients with established atherosclerotic cardiovascular disease who were admitted to our center.
 Patients and methods: Out of 790 patients admitted in our center between May and October 2021, we analyzed 341 patients who underwent isolated coronary artery by-pass surgery. Risk factors were noted as well as previous drug therapy, previous COVID 19 infection and vaccination. Anthropometric data were measured and BMI was determined. Obesity was defined as a BMI >_30 kg/m2 and overweight as a BMI between 25 and 30 kg/m2 . Patients with a BMI >_40 kg/m2 were considered morbidly obese. Early cardiac rehabilitation (phase 1) was performed by using personalized approach in all patients.

 Out of 341 patients (64.68±7.91 years of age), 275 were males (80.6%). The total of 97 (28.44%) had previous myocardial infarction. Blood pressure was well controlled. Majority of the patients reached the step 2 goals according to EAPC Guidelines on prevention (130.7±6.45/75.27±6.54mmHg), and were adherent to prescribed drugs. Mean heart rate was 65±5.65/minute. Only 27% of females and 22% of males had normal weight with BMI between 18.5 and 24.9.kg/m2. The mean BMI was 27.76 kg/m2. 50% of males and females were overweight. Obesity was noted in 23% of females and 27% of males (0.7% morbidly obese. Early cardiac rehabilitation was performed in all patients and they were all referred to participate the phase 2 programs.

 Diet and body weight reduction in overweight and obese ASCVD patients should continue to be a priority given the impact on cardiovascular risk. There is a potential for optimizing management of overweight and obesity in patients. In addition to a better risk factor profile, weight loss also leads to a better quality of life. Cardiovascular prevention and rehabilitation programs should include weight loss intervention. Different forms of self-support and use of digital health might be used as a specific component of a comprehensive intervention to reduce total cardiovascular risk, extend life expectancy, and improve quality of life.


The scientific search for extraterritorial intelligence (SETI) began when Cocconi and Morrison (1959) pointed out that human radio technology (then achievable broadcast power and detection sensitivity) had reached a stage that would allow communication over interstellar distances. At the time, the range over which human radio technology could marginally detect and communicate with an alien civilization having identical capabilities was of order 10 pc (30 light years). Today the corresponding distance is roughly a thousand times larger. That influential paper and its immediate implementation by Drake in the following year set the course of the vast majority of SETI efforts that have transpired during the intervening decades in three important ways: First, nearly all searches have concentrated on the radio band. Second, the paradigm of considering the possibility of detecting a technological "twin" of our own human civilization using existing or clearly foreseeable terrestrial telescopes and instrumentation has remained the dominant theoretical template for determining which of the many possible approaches to SETI are "plausible" and thus worthy of implementation. Third, Earth-like planets orbiting in the Habitable Zones (HZ) of a Sun-like stars have been presumed to be the most promising, and often the only plausible, targets for SETI observations. In short, SETI has concentrated very heavily on looking for a "mirror-image" of ourselves for over half a century, without success so far it hardly need be added. Here we propose a systematic series of preliminary theoretical investigations of alternative approaches to SETI in which we will abandon all three of these elements of the now conventional paradigm described above. First and most straightforwardly, we will consider wavelength bands across the whole electromagnetic (EM) spectrum and perhaps even non-EM possibilities. Second, we will factor the usual "twin technology" standard into two components. Namely, we will ask both: (i) what level of activity (emission) would be required for an alien civilization to be detected using telescopes and instrumentation now or soon available to us?, and (ii) what detection sensitivity would we be required to achieve in order to detect a "twin" of current human civilization? The answers to both questions will obviously be a function of the distance to the alien civilization/activity, and this is a segue to the third point. Third and perhaps most provocatively, we will abandon the traditional focus of SETI thinking on plausibly Earth-like natural environments and instead consider a very wide range of other astrophysical environments, ranging from the vicinities of stellar remnants through interstellar space to the outer parts of the Solar System. In addition to these theoretical studies, we propose to carry out a demonstration or "pathfinder" project by implementing one alternative SETI technique via "mining" of a large PanSTARRS data set which will become available to us during the award period. Before proceeding to say more about our planned work, we should make it clear that we do not intend either the comments above or the papers we hope to write as a criticism of the conventional approach to SETI. The logic motivating it and the discipline it imposes on ideas that might otherwise become too speculative continue to be persuasive in many


The law regulates administrative action, and the way it leads to success is called good Governance. Thus, good Governance may be said as the systematic execution of the laws of the land. The main object of the present research was to find out the essentials of Good Governance, which ensure the formation of a civilized, lawful, and progressive society in which rule of law is maintained in letter and spirit within the constitutional framework. The study also explains the future of good Governance for excellence through public administration while highlighting the deteriorated administrative conditions in Pakistan with historical perspective, its causes, and corresponding reforms. As Governance is related to the society and public thus, it must be open and known to all the public.Equality before the law and special privilege to no one is one of the principles which should be maintained at all levels of government. There search explains that good Governance aims to uphold the principles of confidence, reliability, validity, participation, fairness, accountability,transparency, efficiency, etc., while dealing with affairs of the state


Mediterranean monk seals Monachus monachus are classified as Critically Endan- gered on the IUCN Red List, with <600 individuals split into 3 isolated sub-populations, the largest in the eastern Mediterranean Sea. Canine teeth collected during the last 2 decades from 45 dead monk seals inhabiting Greek waters were processed for age estimation. Ages were best estimated by counting growth layer groups (GLGs) in the cementum adjacent to the root tip using un - processed longitudinal or transverse sections (360 µm thickness) observed under polarized light. Decalcified and stained thin sections (8 to 23 µm) of both cementum and dentine were inferior to unprocessed sections. From analysing patterns of deposition in the cementum of known age- maturity class individuals, one GLG was found to be deposited annually in M. monachus. Ages ranged from 0.5 to 36 yr for females, 0.5 to 21 yr for males and 0.5 to 25.5 yr for individuals of un - known sex. The majority of seals (65%) were considered adults (≥4 yr), followed by juveniles (20%, <1 yr) and sub-adults (15%, 1�3.9 yr). Thirty percent of the aged sample had died from human-related causes, such as accidental entanglement in fishing gear and direct killings. A sin- gle-Gompertz growth curve was generated for both sexes using standard length data, resulting in asymptotic values of 212.3 cm for females and 221.8 cm for males. This study represents the first quantitative glimpse of sex-specific growth in monk seals and the age structure of dead individu- als in this rare species' core range.


Photons with a mean energy of 294 MeV yielded photoprotons from a deuterium target at a mean angle of 58\ifmmode^\circ\else\textdegree\fi{} in the laboratory. The protons were observed in a carbon-plate spark chamber and measurements of their elastic scattering in the carbon were used to determine the polarization components of the protons. The component parallel to the photodisintegration plane was found to be consistent with a value of zero within the statistical errors of the measurement as was expected. The component of polarization perpendicular to the photodisintegration plane was observed to be small and negative, and not inconsistent with a value of zero.


A method for dynamically derive a delay aggregation for aggregating packets in a wireless network, comprising the following steps: deriving a delay optimal aggregation in a network node based on information on parameters related to the channel quality node wireless network thanks to the use of a controller; whereby information on parameters related to the channel quality is measured in the node-based wireless network environment; and on the information on parameters related to the channel quality reports it comprises loading channel comprising information on the existing load on the network.


Objective
To investigate the correlations of peripheral blood platelet-to-lymphocyte ratio (PLR) with large atherosclerotic (LAA) stroke and its severity.

Methods
Inpatients with acute ischemic stroke admitted to hospital were enrolled retrospectively. They were divided into LAA and non-LAA (including cardioembolism, small vessel occlusion, other undetermined etiology, and undetermined etiology) according to the TOAST classification. LAA was further divided into a mild stroke group (score <8) and a moderate to severe stroke group (score ≥8) according to the National Institutes of Health Stroke Scale. The general clinical data, laboratory measurements, and PLR were compared. Multivariate logistic regression analysis was used to identify the independent risk factors for LAA and its severity.

Results
A total of 676 patients with acute ischemic stroke were enrolled, including 391 patients with LAA, 224 of them with mild stroke and 167 with moderate to severe stroke; 285 with non-LAA, including 94 cardiogenic embolism, 137 small vessel occlusion, 18 other undetermined etiology and 36 undetermined etiology. PLR in the LAA group was significantly higher than that in the non-LAA group (172.24±70.45 vs. 148.37±45.84; t=5.001, P<0.001). Multivariate logistic regression analysis showed that PLR (odds ratio 1.012, 95%confidence interval 1.004-1.021; P=0.006) was an independent risk factor for LAA. PLR in the mild LAA group was significantly lower than that in the moderate to severe LAA group (149.74±47.68 vs. 202.42±83.70; t=7.864, P<0.001). Multivariate logistic regression analysis showed that PLR (odds ratio 1.025, 95% confidence interval 1.008-1.042; P=0.003) was an independent risk factor for the severity of LAA.

Conclusions
PLR is associated with LAA and its severity.

Key words:
Stroke; Brain Ischemia; Blood Platelets; Platelet Count; Lymphocytes; Lymphocyte Count; Severity of Illness Index; Risk Factors


Abstract Brownfield regeneration, involving the reintegration of derelict and abandoned sites into their economic environments, is a key element of sustainable urban development. To realize the full potential brownfield regeneration offers to sustainable urban development, the parameters that influence the degree of sustainability within brownfield regeneration itself have to be understood. An analysis of eight sites in four European countries identified strengths and weaknesses in current brownfield regeneration practice. Among other outcomes, criteria for sustainable brownfield projects and the "Sustainability Assessment Tool for brownfield regeneration projects" (SAT) were developed. The tool is based on a framework of objectives, indicators and best practices that reflect the multi-dimensional and multi-stakeholder complexity that characterizes brownfield regeneration. The SAT would be one option to implement sustainability criteria without waiving the local and regional context. The SAT offers one way for brownfield projects being put forward for public and specifically European Union, funding to be evaluated. This would be a remarkable innovation, leading to not only more efficient use of public money but also an increase in quality of brownfield regeneration.


Firstly in Ukraine as the result of resiprocal interbreedings of autotetraploid (2n=4x=32) / diploid (2n=2x=16) and diploid (2n=2x=16) / autotetraploid (2n=4x=32) four sintetic triploid (2n=3x=24) hybrid forms (611-91, 13-93, 14-93, 18-93) have been obtained. Spontaneous triploid nectarinum 166-80 has been shared out from diploid hybrid seedlings population. Tetraploid and triploid nectarinum forms are valuable sources for directoinal selection and making hybrids with the complex of new signs, which are difficult or impossible to receive on diploid level.


Distributed blockchain-based consensus platforms have witnessed steady growth in recent years. In special, cryptocurrency is one of the main applications of the blockchain technology. Despite the recent interest in blockchain, we still lack in-depth analysis of systems that use such a technology. In fact, most of the existing works focus on Bitcoin. Moreover, blockchain-based cryptocurrency systems are highly dynamic. Their internal mechanisms and consensus algorithms evolve over time. Users also change their interests in a given platform, which in turn, reflect their behaviour. In this article, we model the Ethereum-based cryptocurrency transaction network, a more recent blockchain platform that is gaining a significant share in the cryptocurrency market. We model the transactions of Ethereum as a complex system, representing this complex system as a time-varying graph. Our model and the analysis we conduct rely on a 3-year dataset of Ethereum-based cryptocurrency transactions, comprising more than 38 million users (i.e. unique wallet addresses) and almost 300 million transactions. We analyse the evolution of users and transactions over time. Our study also highlights the centralization tendency of the transaction network on both user and time aspects. Finally, we also analyse the formation of communities and the evolution of connected components considering the dynamics of the Ethereum-based cryptocurrency transaction network.


(1) Utrecht University, Department of Physical Geography, PO Box 80.115, 3508 TC Utrecht, The Netherlands (firstname.lastname@example.com), (2) Deltares, PO Box 177, 2600 MH Delft, The Netherlands (email@example.com), (3) University of Twente, Faculty of civil engineering, PO Box 217, 7500 AE Enschede, The Netherlands, (4) ICIS-University of Maastrict, PO Box 616 6200 MD Maastricht, The Netherlands (firstname.lastname@example.com)


Now a days one of the major problem faced in the country, is the management of solid organic wastes. In the present study, the most common and useful species of earthworm i.e; Eudrilla euginae was introduced in terms of converting various bio-wastes in to vermicompost. The experiment was carried out in earthern pots during July, 2008. The four bio-wastes sites of the city like garbage of the city, paper waste, house hold waste and vegetable waste were taken under the observation. Just after the experiment data were analyzed for the results. The result clearly indicates that the various bio-organic wastes have significant role on growth and development of earthworms as well as production of vermicompost. The highest amount of production of vermicompost was recorded from the vegetable market wastes (5.6kg), whereas the lowest (3.2kg) was noted from the garbage of the city from the total waste of (9.0) kg. The other sources of organic bio-wastes also proved good results for the conversion of organic bio-wastes in to vermicompost.


The limited period of observation used by household budget surveys leads to several problems including that of how to interpret and cope with the many non-buyers of narrowly defined products. Using some National Food Survey data on purchases we suggest a technique involving maximum likelihood methods for approximating the consumption of different types of household and make an application of the logit-linear model to characterize the buyers of each product.


Background: Percutaneous nephrostomy (PCN) is indicated to drain the upper urinary tract collecting system in cases of obstruction. Objective of our study is to evaluate the safety and efficacy of Ultrasound guided direct puncture PCN in our populations.Methods: This observational study was conducted from May 2020 to April 2021in department of urology and renal transplant. The total 65 patients with upper urinary tract obstruction requiring PCN were enrolled. All parameters were recorded and statistical analysis was performed using the Statistical package for the social sciences (SPSS 16.0) for windows.Results: In our study Ca Cervix with ureteric infiltration (35%) was the most common indication for PCN tube placement. Majority of patients (83%) had Grade IV and Grade III hydroneprosis. Single attempt for tube placement was sufficient most of the time in (86% cases). Direct Puncture PCN tube placement was successful in 62 (95.4%) cases. The mean duration of procedure was 12.4 minutes. Loin pain was the most common procedure related complication observed in 58 patients. There was no evidence of visceral injury, no need of blood transfusion in post procedural duration in our study.Conclusions: USG guided direct puncture PCN technique is simple, low cost, less time consuming, less chance of loss of tract and effective procedure for drainage of urine in case of upper urinary tract obstruction. We recommended this procedure in grade III and IV hydronephrosis and this procedure suitable for developing countries like India because of procedure related low cost.


An architecture for a Cell Switch Fabric (CSF) with a new bus assignment strategy is presented. The proposed architecture has a modular structure with a chip partitioning oriented to avoid the system from falling down totally, thus achieving expandability and increasing reusability. A discussion about different algorithms for the bus assignment is given. The shared bus is assigned in a cyclic and rotative way, switching microcells instead of cells. The CSF is built in four PCBs where every one has a capacity for four ports at 164.323 Mbps, the external port rate is 155.52 Mbps. A microcontroller realizes some tests and communicates with a PC, which runs a test, verification and CSF configuration program. Some parameters about the CSF behavior are measured too. Each Port was implemented on a CPLD FLEX10K100 and the Switch Control Block on a circuit MAX7128, both from Altera Company.


We develop a visualization tool for designing a topology-aware communication algorithm. This tool visualizes the communication behavior from the logs of a network simulator or an existing parallel computer. Using multiple views, filtering functions, and an animation function, the tool affords users an intuitive understanding of communication behavior and provides statistical information. The topology view represents the spatial load distribution of the network topology in 3D space. The user can analyze the communication behavior on a specific network topology. A distinction between the behaviors of the new all-to-all communication algorithm and the conventional one is drawn clearly by the tool. In addition to the poster presentation, we are going to present a communication algorithm behavior on PC using our visualization tool.


P-π conjugated polyamic acid(PAA) was synthesized by the poly-condensation of benzoguanamine(BGA) and pyromellitic dianhydride(PMDA) under microwave irradiation. Then PAA was grafted with different side-chain containing azobenzol groups through azo coupling reaction. The new NLO side-chain PAAs synthesized were characterized by FT-IR, UV-Vis, elemental analysis, FT-IR and ()~1H-NMR. The third-order optical nonlinearities and time responses were measured by a phase conjugate forward, 3-dimensional degenerate, four-wave mixing(DFWM) technique. Comparing polymers third-order NLO coefficient, it shows that the χ~~((3)) value increasecs with the introduction of the azobenzol side-chain. The electron withdrawing and push ability of the different substituting group affect the χ~~((3)) value in different degree.


The aim of this article is to show the role played by whole range of favorable biopsychic factors and their impact on school achievements in Polish language, mathematics, self-help, social functioning, music, plastic arts, physical education and technical skills of middle mentally retarded children with Down's syndrome and mentally retarded children without Down's syndrome.


In the United States, items in police possession are often sold at auction if they are not claimed. This includes cellphones that the police obtained through civil asset forfeiture, that were stolen, or that were turned in to lost-and-found. Thousands of US police departments partner with a website, PropertyRoom, to auction their items. Over the course of several months, we purchased 228 cellphones from PropertyRoom to ascertain whether they contained personal information. Our results show that a shocking amount of sensitive, personal information is easily accessible, even to a "low-effort" adversary with no forensics expertise: 21.5% of the phones we purchased were not locked at all, another 4.8% used top-40 most common PINs and patterns, and one phone had a sticky-note from the police with the PIN on it. We analyze the content on the 61 phones we could access, finding sensitive information about not only the phones' previous owners, but also about their personal contacts, and in some cases, about victims of those persons' crimes. Additionally, we analyze approximately two years of PropertyRoom cellphone auctions, finding multiple instances of identifying information in photos of the items being auctioned, including sticky-notes with PINs, owners' names and phone numbers, and evidence stickers that reveal how the phones were obtained and the names of the officers who obtained them. Our work shows that police procedures and phone auctions can be a significant source of personal information leakage and re-victimization. We hope that our work is a call to arms to enforce new policies that either prohibit the selling of computing devices containing user information, or at the very least impose requirements to wipe phones in a manner that the US federal government already employs.


The luminescence emission of CdS single crystals is investigated in the exciton spectral region for high one-photon and two-photon excitation at 1.8 K. The inelastic scattering of two excitons (P-line) is resolved into three distinct lines, corresponding to the transition of one exciton from the 1s state into the states 2p, 3p, and n = ∞. The latter transition leads to photoconduction. The lines M and PM, discovered by Shionoya et al. and ascribed by him to the recombination and inelastic scattering of exciton molecules, are interpreted as Stokes acoustical phonon wings of the exciton–impurity complex lines I2 and I1. The M and PM-lines are stimulated at high intensities. The onset of several laser modes is observed for the PM-line. The mechanism of this two-boson (photon and acoustic phonon) laser is discussed.

Die Lumineszenz von CdS-Einkristallen wird im Spektralbereich der Exzitonen unter hoher Ein-Photonen- und Zwei-Photonen-Anregung bei 1,8 K untersucht. Die inelastische Streuung von zwei Exzitonen (P-Linie) wird in drei Linien aufgelost, die zu den Ubergangen eines der Exzitonen aus dem 1s-Zustand in die Zustande 2p, 3p und n = ∞ gehoren. Der Ubergang in n = ∞ liefert bewegliche Ladungstrager, die zur Photoleitung beitragen. Die M- und PM-Linien, die von Shionoya et al. entdeckt und der Rekombination bzw. inelastischen Streuung zweier Exzitonenmolekule zugeschrieben werden, werden als die Stokesschen akustischen Phononenseitenbanden der Exziton–Storstellenkomplex-Linien I2 und I1 gedeutet. Die M- und PM-Linien werden bei hohen Anregungsintensitaten stimuliert. Fur die PM-Linien wird das Anschwingen von mehreren Laser-Eigenschwingungen beobachtet. Der Mechanismus dieses Zwei-Boson-Lasers (Photon und akustisches Phonon) wird diskutiert.


The state-of-the-art of the theory and control of NO/sub x/ emissions from combustors is reviewed including the mechanisms and kinetics of the formation of thermal and fuel NO/sub x/, its destruction by reactions with char and reducing gases, and NO/sub x/ emissions control technology and mathematical modeling of fluidized-bed combustors. Practical conclusions are drawn, some unsolved problems are described, and recommendations are made as to various topics which require further study.


Platinum electrodes were chemically modified with tris(5-amino-1,10-phenanthroline) ruthenium(II) via electropolymerization. The characterization of the thin films was accomplished with cyclic voltammetry (CV) and Rutherford Backscattering Spectrometry (RBS). Data indicates a strong correlation between the peak currents from the characterization cyclic voltammograms and the number of cycles of electropoly-merization. Rutherford Backscattering Spectrometry showed the same trend, and verified that film thickness is strongly dependent on the concentration of the monomer ruthenium solution. Film thickness was determined from the change in ion beam energy as it passed through the film and was calculated to be 1.0 x 1018 atoms/cm2 – 3.4 x 1018 atoms/cm2, depending upon the number of electropolymerization cycles. The electrodes also showed differences in surface roughness, which were dependent on film thickness.


As the high-density flash memory, such as triple-level-cell (TLC) and 3D flash memory, has gradually dominated the market share, flash-memory-based storage devices also have suffered from the exacerbated performance and endurance problems. In order to improve the endurance of flash devices, wear-leveling and refreshing designs were proposed to evenly distribute erase operations among all flash blocks and to timely correct and re-write data of flash blocks, respectively. However, as these designs mainly aim at enhancing the endurance for flash devices, the performance issue is getting aggravated instead. Such contradiction between performance and endurance improvements drives this research to propose a time harmonization strategy, which harmonizes the block retention time with the data lifetime to enhance performance of flash devices with limited sacrifice to endurance. The experiments were conducted on trace-driven simulation with intensive and realistic workloads. Compared with the existing designs, the proposed design can effectively reduce the redundant writes by 26.8% with merely degrading the overall endurance by 0.4% on average.


In this report, we demonstrate high spectral responsivity (SR) solar blind deep ultraviolet (UV) β-Ga2O3 metal-semiconductor-metal (MSM) photodetectors grown by the mist chemical-vapor deposition (Mist-CVD) method. The β-Ga2O3 thin film was grown on c-plane sapphire substrates, and the fabricated MSM PDs with Al contacts in an interdigitated geometry were found to exhibit peak SR>150A/W for the incident light wavelength of 254 nm at a bias of 20 V. The devices exhibited very low dark current, about 14 pA at 20 V, and showed sharp transients with a photo-to-dark current ratio>105. The corresponding external quantum efficiency is over 7 × 104%. The excellent deep UV β-Ga2O3 photodetectors will enable significant advancements for the next-generation photodetection applications.


Parallel current source converter (CSC) with multilevel modulation has the advantages to increase the system power range, reliability and improve output quality. In this paper, an interleaved sinusoidal pulse-width modulation (SPWM) for paralleled CSC system is proposed. The gating signals for each CSC are produced by comparing two triangular carriers and three-phase current references directly. Multilevel output can be achieved by simply interleaving the carriers. Comparing to the multilevel space vector modulation (SVM), the proposed method is more straightforward and easier to extend to N-CSC parallel system due to its inherent scalability and modularity. Moreover, lower common-mode voltage (CMV) and circulating current can also be achieved by the proposed SPWM strategy compared to multilevel SVM. The validity and effectiveness of the proposed method are verified on a paralleled CSC system with both simulation and experimental results.


Mechanical and corrosion properties of spot‐welded high‐strength austenitic stainless steels EN 1.4318 2H/C1150 and EN 1.4318 2H/C850 were studied. Microhardness measurements, lap shear and cross‐tension tests, corrosion fatigue tests and corrosion tests were carried out. The corrosion environment was 3.5% sodium chloride solution at +50 °C in the corrosion fatigue tests and 3.5% sodium chloride solution at ambient temperature in the electrochemical pitting corrosion tests. Stainless steel EN 1.4318 2H/C850, t = 1.92 mm, exhibited better fatigue endurance than EN 1.4318 2H/C1150, t = 1.2 mm, and EN 1.4318 2H/C850, t = 1.0 mm, stainless steels did. There were no significant differences between the stainless steels of different strength levels (2H/C850 vs. 2H/C1150) in the line load range analysis of the fatigue data. High hardness gradient was found in the heat‐affected zone (HAZ) of EN 1.4318 2H/C1150 stainless steels. EN 1.4318 2H/C1150, t = 1.2 mm, stainless steels seemed to have slightly higher lap shear strength with the same nugget diameter as EN 1.4318 2H/850, t = 1.9 mm, stainless steel. In the case of EN 1.4318 2H/C1150 stainless steel increase in the nugget diameter bigger than required 5√t did not increase the cross‐tension force significantly. The pitting corrosion susceptibility of the spot‐welded samples and the base materials of the steels EN 1.4318 2H/C850 and EN 1.4318 2H/C1150, t = 1.2 mm, was investigated by measuring the corrosion current for 1 h at +100 mV versus saturated calomel electrode (SCE) in 3.5% sodium chloride solution at ambient temperature. Pitting corrosion occurred in all spot‐welded samples but not in the base materials. There was a difference between the investigated steels in the location of the pits. In stainless steels EN 1.4318 2H/C850 the pits appeared around the spot weld, but in the steel EN 1.4318 2H/C1150, t = 1.2 mm, the pits are located mainly at the spot‐weld area.


In theorem 3.1 of Chen and Hsu (1995) an expressin for an upper confidence bound for Cpmk in the case when µ = M and so Cpmk = Cpm, is given as a multiple of Cpm. However, if the value µ = M known then it would be more reasonable to use the estimator obtained by replacing Xn by M.


As communication technologies change, so do libraries. The computer monitor has replaced paper text as the dominant medium of immediate communication. Library instruction programs are now focused on teaching information literacy, a term that may just as well be referred to as information "literacies." The new media age involves information in a wide variety of mediums. Only about 15 percent of the average person's time is spent communicating through reading and writing (Walsh, 2007).


This article explores the relationships between human resource (HR) flexibility, organizational culture, and organizational performance. Drawing on previous works, we develop a conceptual model that links the constructs together. It is hypothesized that the three sub-dimensions of HR flexibility (i.e. employee skill flexibility, employee behaviour flexibility, and HR practice flexibility) affect adaptability culture, which in turn impacts HR-related and market-related outcomes. The data were collected via a questionnaire survey of HR directors/managers in multinational corporations (MNCs) in Hong Kong. The results of structural equation modelling (SEM) reveal the positive effects of employee behaviour flexibility and HR practice flexibility on adaptability culture. Employee skill flexibility, however, exerts no such effect. Further, adaptability culture is found to affect both HR-related and market-related performance in a positive manner.


Social media has played an important role as hub for information in political change. It can contribute to the development och psychological and social preconditions for dialog and democracy.


Ground deformation in goaf is affected by various factors. Basic on FLAC3D, making use of the flexibility of numerical simulation, we choose Coulomb-Moore Mode that is applicable to rock-earth materials, and study the influence on ground deformation from the mining depth and thickness to the depth/thickness ratio. The focus of the study is the qualitative analysis that the influence of the depth/thickness ratio on ground deformation from the simulation results. From the results we can make conclusions as follow : with the increasing of the mining depth, ground deformation decrease conversely. The larger of the mining thickness, the faster of ground deformation increasing. And in goaf with the same depth/thickness ratio while in different depth and thickness, the influence of the mining thickness on ground deformation is slightly larger than the mining depth.


Abstract Relatively mild night temperatures can reduce leaf carbon dioxide exchange rates (CER) and dry matter (DM) accumulation in peanut (Arachis hypogaea L.). To investigate differences among cultivars in response to long-term exposure to a range of night temperatures, three peanut cultivars (OAC Ruby, Chico, and Early Bunch) with known differences in chilling sensitivity were grown in controlled-environment cabinets at the University of Guelph, Ontario. Effects of long-term exposure to night temperatures from 9 to 20 C were assessed in terms of leaflet and whole plant CER, DM accumulation, and phenological development. Effects of night temperature on rate of phenological development and DM accumulation were consistent with differences in accumulation of degree-days. Cultivars did not differ in daytime leaf CER response to all night temperatures except 9 C, at which CER for OAC Ruby was higher than for Early Bunch or Chico. CER in the 9 C treatment was 92% of the CER at 20 C for OAC Ruby and 80% for Ea...


A 43-year-old female, who had been suffered from the recurrent aphthae for about two years, visited our otolaryngology clinic on April 18, 1985, with complaints of the dysphagia and swallowing pain.One year later, the dyspnea appeared due to the stenosis of the hypopharynx and the swelling of the epiglottis, followed by an ulcerating mucosal lesion.She was admitted to our hospital on June 5, 1986. The emergency tracheostomy and intravenous administration of the steroid hormone and antibiotics were performed. After these treatments, the swelling of the hypopharynx was improved, but the stenosis was remained. Surgical correction of the stenotic hypopharynx was accomplished under the laryngo-microsurgery using CO2 LASER, and the dyspnea was improved.Although the recurrent aphthous stomatitis is not so uncommon disease, the secondary stenosis of the pharynx and larynx is very rare.The cause, pathology and therapy of this type of aphthous lesion were briefly reviewed.


To deal with wind field disturbance in DR/GPS/RP integrated navigation of UAV, a method of wind field estimation and trajectory correction online based on the relation of position vector was proposed. In addition, in order to obtain more accurate wind field information, a method about estimating the calculation step considering Shannon sampling theory was introduced. The results of simulation and experiments show that the method above can accurately estimate the wind field and thus restrain the divergence of DR and improve the accuracy of integrated navigation and the ability of anti-disturbance.


Abstract Poor organization has a negative impact on how and what children learn in sport skills teaching situations and encourages poor student behavior.


Abstract We find approximate solutions (chord–arc curves) for the system of equations of geodesics in Ω∩ℍ for every Denjoy domain Ω, with respect to both the Poincaré and the quasi-hyperbolic metrics. We also prove that these chord–arc curves are uniformly close to the geodesics. As an application of these results, we obtain good estimates for the lengths of simple closed geodesics in any Denjoy domain, and we improve the characterization in a 1999 work by Alvarez et al. on Denjoy domains satisfying the linear isoperimetric inequality.


The utility model discloses a flexible coating for outer wall attaches to the basic unit and the skin of wall body in proper order, the basic unit is including the first tie coat, putty layer and the second tie coat that attach to the wall body in proper order, the skin attaches to the second tie coat. The putty layer is formed by flexible putty coating. Outer surface adhesion has the inoxidizing coating. The utility model discloses a tie coat makes the strength increase who scribbles the layer structure, to the setting on putty layer, makes the putty layer have better first intensity and the adhesive strength of gluing to adhere to the protective layer on the skin, make outer structure more closely knit. Compared with the prior art, the utility model discloses three kind above modes are taked to the coating, make the intensity of scribbling the layer structure strengthen.


To control the flow around a flat plate, a small rod was set upstream of the plate. The chord length of the plate, D, was 50 mm. The diameter of the rod, d, and the distance between the axes of the rod and plate, L, were varied. The Reynolds number ranged from 1.3 × 104 to 7.7 × 104. For the cases without vortex shedding from the rod, the shear layer from the rod reattaches to the front face of the plate. Consequently, quasi-stationary vortices are formed between the rod and the plate. In this case, at d/D = 0.4 and L/D = 1.4 to 2.0, the maximum reduction of total drag coefficient is 20 to 30%. The average heat transfer on each face increases and the overall heat transfer increases by about 40 to 50% compared with values obtained without the rod in place. © 1998 Scripta Technica, Heat Trans Jpn Res, 27(2): 99–113, 1998


MEMS technology has been extensively used in various applications since its development. One of the common applications is an inertial sensor. Growing popularity of MEMS inertial sensors is due to the sensor's miniature size and economic cost. On the other hands, a low bias stability and a strong temperature characteristic of MEMS based product affect the accuracy of the data output. This is fatal to the applications that require high accuracy because even a small margin of the error could accumulate and lead to the utter failure in the application's performance; therefore, it is necessary to control or compensate the sensor's bias and scale factors. Measurement based correction requires a large amount of human work and a time consuming observation. This document presents a framework for the automation of the conventional correction. For the automation, the rate table control software and the software for data collection and analysis have been developed. With the implementation, the speed of overall process was upgraded by using default reference values to correct bias and scale factors. This automatic test technique expects to increase overall testing efficiency by conserving time and human work while increasing an accuracy of the result.


Providing an engine exhaust gas recirculation control means is provided to prevent the EGR flow path EGR sensor defaced polluting substances in the exhaust gas. Corresponding to the state of the catalyst, an appropriate control state of the EGR sensor. Thus, no matter what circumstances EGR EGR sensor in the flow path of the exhaust gas is difficult to be affected fouling substance, reducing the detection accuracy of the EGR gas can be prevented. May EGR gas is recirculated from an exhaust passage disposed downstream of the main catalyst.


Tabloid journalism is a contentious phenomenon that has provoked debate in many countries, including Indonesia. The main accusation levelled at this genre of journalism is sensationalism. However, tabloid journalism actually offers new perspectives by catering to the taste of the 'untouched' readers previously ignored by mainstream newspapers. This article describes the phenomenon of tabloid journalism in Indonesia through an analysis of the two highest circulating Indonesian tabloid newspapers, Pos Kota and Lampu Hijau. It is based on a combination of quantitative content analysis and qualitative email interviews (conducted in 2011-2012) as its research methods. The main goals of this research are to reinvent the characteristics of tabloid journalism in Indonesia as exemplified by Pos Kota and Lampu Hijau, as well as to discover the role these papers play in the development of Indonesian journalism.


In distributed computing systems, an important design factor is the assignment of data to the collection of distributed resources. This paper is concerned with the initial -igrtment of portions of a distributed directory to locally managed subdirectories. Thii problem is studied within the context of the X.500 Directory standard, a CCITT/ISO series of recommendations intended to "facilitate the interconrrection of information processing systems to provide directory services." The X.500 standard constrains the problem by impo4ng specific operations and data constraints on the Directory. A model of distributed directory is proposed, and a heuristic algorithm for partitioning is presented and ita effectiveness is examined.


Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives: The recently published Sepsis Core Measure incorporates the three-hour and six-hour bundles as recommended by the Surviving Sepsis Campaign. However, adoption and implementation of a sepsis order set that incorporates such recommendations has been limited. Methods: This was a retrospective, single center, observational study of patients who were initiated on a sepsis management order set from January to March of 2016. Results: A total of 129 patients were evaluated, of which 30 patients completed all necessary components of the order set, and 99 patients did not. The order set compliant group had a numerically lower mortality rate compared to those who did not (6.7% vs. 14.1%, p = 0.36). Of the patients that expired, 12.5% were treated completely with the order set and 87.5% were treated incompletely with the order set. Sepsis with hypotension or hyperlactatemia was present in 10% of patients in the order set compliant group and 57.6% of patients in the non-compliant group (p < 0.01). Core measure compliance was 100% in the order set compliant group, and 30.3% in the noncompliant group (p < 0.01). Of the elements executed from the order set, significant differences in compliance were observed for antibiotic administration within the first 3 hours of the order set initiation (100% vs. 76.8%, p < 0.01), as well as perfusion assessment after fluid administration (100% vs. 7.1%, p < 0.01). No statistically significant differences were observed in hospital length of stay, use of renal replacement therapy, or mechanical ventilation. The order set compliant group had shorter ICU length of stay (0 vs. 2 days, p = 0.04). Conclusions: Lower mortality, ICU length of stay, and higher core measure compliance rate were observed in patients that met all components of the sepsis order set. However, patients with hypotension or hyperlactatemia often failed to meet all components of the six-hour bundle and are not largely represented in the order set compliant group. Better compliance with the sepsis order set in patients with hypotension or hyperlactatemia may improve core measure compliance and survival.


in 2018, Badan Pengkajian dan Penerapan Teknologi (BPPT) has developed composite sluice for controlling flood goals. The integration of retention pond and composite sluice deemed necessary to be analyzed as the integrated system as a flood disaster mitigation effort. This study aims to give a brief overview of the suitable retention pond capacity, which is integrating with composite sluice as a flood prevention effort. The retention pond designed in this study requires rainfall data, land use data and topography map. This study method uses empirical formulation based on statistical parametric on hydrology analyze and hydraulic analyze as a basis of retention pond capacity calculation and composite sluice as flood controller. The result of this study are; the maximum flood discharge in 10 years return period is 103,28 m3/s, while the riverbed discharge capacity with 8 meters width is 68,29 m3/s. To prevent flooding the retention pond volume with capacity volume in 1.117.214,24 m3 has required. In sluice practical width calculation for the retention pond, the resulting amount is 28,70 meters. It takes 32 units of composite sluice if the current needs to be maintained. The side composite sluice width has obtained 1 meter while the total composite sluice building width with four units for the retention pond is 6,4 meters.


Many image processing languages support the concept of a neighborhood or structuring element. In such image processing languages, a neighborhood is usually defined similarly to an image. Operations involving an image and a neighborhood yield a resultant image by some kind of convolution of this single fixed neighborhood with the source image. In this paper we show how generalizing the neighborhood concept to permit neighborhoods that are functionally specified and can vary from pixel to pixel within an image can provide a powerful algebraic language for image processing. Many complex image processing procedures requiring multiple operations to describe in other languages, such as rotation of an image by an arbitrary angle, can be described by a single algebraic operation involving a functionally specified neighborhood. We give examples of the use of functionally specified neighborhoods and argue that this general approach to neighborhood operations is appropriate for implementation on state of the art computer architectures.


The compound operation input device with a rotating operation and pressing operation by a common member, and the elevation of the rotatable member is supported on the operation (1), splined relief plate (4), a central cylindrical portion (13a ) with return spring (5) holding the relief plate (4), an operation member (1) by a rotational operation of a photo-interrupter (8,9) is detected, the operation member (1) by the relief plate (4) detected by the vertical movement of the cylindrical portion (3c) by a photo interrupter (10). Thereby providing an inexpensive easy to achieve a long life, miniaturized compound operation input device.


AbstractAim:To investigate the biological activity of human lens epithelial cells (HLEC) in producing inducible nitric oxide synthase (iNOS) and nitric oxide (NO), and to assesse the effect of diethyldithiocarbamate (DDC) on iNOS mRNA levels and expression of NOS.Methods:The human lens epithelial cell line SRA 01/04 was used in this experiment. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blotting were used to detect, respectively, iNOS mRNA expression and protein production.Results:A costimulation by interferon gamma (IFN-γ) and lipopolysaccharide (LPS) was necessary for iNOS expression in HLEC. The expression of iNOS was significantly reduced in a dosedependent manner by adding DDC from 10 μmol/L to 1 mmol/L.Conclusion:The expression of iNOS in HLEC needs co-stimulation with IFN-γ and LPS and it is inhibited by DDC.


The paper discusses modelling of transport company management systems in a competitive environment. In order to analyse behaviour of the competing transport companies were modelled using an object-oriented structure. The criterion function applied for optimisation and implemented in the model was defined. The performance algorithm of a competitive environment was developed. To verify the proposed approach the model of transport company operating in a completive environment was simulated using AnyLogic software platform.


This paper investigates some relations among four complexities of sequence over countably infinite alphabet, and shows that two kinds of empirical entropies and the self-entropy rate regarding a Markov source are asymptotically equal and lower bounded by the maximum number of phrases in distinct parsing of the sequence. Some connections with source coding theorems are also investigated.


An algorithm is proposed for automatic determination of the correspondence of domestic structural steels to material codes according to the SANDVIK classification. The steel designation and information from the electronic directory "Materials and assortments for KOMPAS" of the ASCON company are used as initial data. The algorithm is implemented in an integrated CAM system for the KOMPAS-3D platform.
Keywords: structural steel, KOMPAS-3D classification, cutting mode, SANDVIK, CAM-system, CNC
firstname.lastname@example.com, firstname.lastname@example.com


The one-electron energy band structure for the rare-earth intermetallic compound LaGe 2 , in which an anomalous specific heat and a superlattice structure have recently been found, is calculated by an APW method with a local-density approximation. Assuming that the superlattice structure may originate from a formation of the charge density wave state, the Fermi surface is investigated carefully. It consists of two sheets, a multiply-connected electron sheet and a multiply-connected hole sheet. A candidate for such flat pieces of the Fermi surface that are responsible for a formation of the charge density wave state with the observed period is a pair of the nearly flat sides of the box-shaped part of the electron sheet.


Purpose – Previous research has demonstrated strong relations between work characteristics (e.g. job demands and job resources) and work outcomes such as work performance and work engagement. So far, little attention has been given to the role of authenticity (i.e. employees' ability to experience their true selves) in these relations. The purpose of this paper is to explore the relationship of state authenticity at work with job demands and resources on the one hand and work engagement, job satisfaction, and subjective performance on the other hand. Design/methodology/approach – In total, 680 Dutch bank employees participated to the study. Structural equation modelling was used to test the goodness-of-fit of the hypothesized model. Bootstrapping (Preacher and Hayes, 2008) was used to examine the meditative effect of state authenticity. Findings – Results showed that job resources were positively associated with authenticity and, in turn, that authenticity was positively related to work engagement, job sa...


An interface stabilized SnOx/Pt(110) nano‐oxide characterized by a c(2 × 4) surface reconstruction is prepared and characterized by low‐energy electron diffraction (LEED), synchrotron radiation photoemission spectroscopy (SRPES), and scanning tunneling microscopy (STM). Based on the experimental data, atomic models for the nano‐oxide are proposed and then validated by comparing the experimental results with the outcome of first‐principle calculations. The reactivity of the nano‐oxide toward CO is investigated, obtaining that the c(2 × 4) reconstruction efficiently oxidizes CO to CO2. The SnOx nano‐oxide on the Pt(110) surface can act as a reservoir for oxygen that can diffuse on the adjacent Pt areas where it oxidizes CO. This spillover effect endows the SnOx/Pt(110) system with enhanced tolerance to CO poisoning.


This paper presents a new technique for constructing Lyapunov functions for estimating the domain of asymptotic stability of nonlinear control systems. A machine program assigns figures of merit (based on the quality of the stability-boundary estimates) to the members of a set of Lyapunov functions and then searches for the one which maximizes this measure. The method is applied to relay-control systems, which are not tractable by other systematic techniques such as the method of Zubov. The paper is divided into two parts. The first part contains a discussion of the motions of relay-control systems and the technique of investigating their stability domains with Lyapunov functions. The second part contains a discussion of existing methods of generating Lyapunov functions and a description of the new method, along with a number of second and third-order examples.


Endovenous laser ablation (EVLA) of the great saphenous vein (GSV) is thought to minimize postoperative morbidity and reduce work loss compared with high ligation and stripping (HL/S). Patients with varicose veins due to GSV insufficiency were randomized to either EVLA (980 nm) or HL/S in tumescent anesthesia. In our clinics, 50 varicosis patients were treated between August 2013 and September 2015. EVLA was applied in 25 cases and HL/S was applied in 25cases. Clinical features and demographic characteristics of the patients were summarized. EVLA procedure was done by 980 nm diode laser (Ceralas D 980, Biolitec) at continues mode with 15 W energy. Patient visits were done at post-operative 10th day, 6th month, 1st year and 2nd year. Routine physical examination and Doppler USG assessments were performed at these visits. EVLA and HL/S procedures were done in complete success in all cases at both groups. All cases were invited for control visits. When complications developed after procedures were evaluated; no infection, hematoma or parenthesis were observed in EVLA group. However in HL/S group; infections, hematomas and parenthesis were observed in 6,4 and 2 cases respectively. In terms of treatment success, there was no recurrence in EVLA procedure while recurrence rate after conventional surgery found in 3 cases. In terms of post-op complication, EVLA method was associated with significantly less parenthesis, hematoma and pain. EVLA method is a method as effective and safe as standard treatment. However, when a long term result of this method is shown completely, its effectiveness will be cleared and its clinical utility will be established.


This paper simply explained the principle and characteristic of hygrometer, calibration of hygrometer. The characteristic of the application of hygrometer in environmental testing equipment, Also introduce the principle and characteristic of psychrometer , finally put forward my opinion about this question,


Arithmetic of two typical absorptive boundary conditions in FDTD arithmetic is described,that is Mur absorptive boundary condition and PML absorptive boundary condition.Then an example of computing radiated electric field of point power in 3D space in vacuum using Matlab language programming is given,and three main computing steps of area partition and writing finite-difference formula and programming are given.And then,the selection of some parameters in dividing FDTD net is provided,as well as gridding builder of PDE toolbox of Matlab.Finally,several conclusions using Matlab language to program FDTD arithmetic is carried out.


The search for a "best practice" of entrepreneurship has been a big part of the science of entrepreneurship of our millennium. Using text analysis, this article empirically investigates the way 756 entrepreneurs from three different cohorts conceptualize two of the 27 elements in such a suggested normative model. The two elements explored are "Core Competence" and "Unique Value Proposition". Our findings are that there may be two problems with the use of these elements. Firstly – the number of entries from each case suggest that entrepreneurs struggle with finding and settling on a "unique" statement for either of the two elements. Secondly, a percentage of the entrepreneurs seem to struggle to differentiate the two concepts from each other. Finally, there seem to be differences between the three investigated cohorts concerning the findings, where higher education and more experience may make it easier to utilize and understand Core Competence and Unique Value Proposition as parts of the entrepreneurial process.


Purpose – This study seeks to examine the interrelationships among three elements of an entrepreneurial orientation (proactiveness, innovativeness, and risk‐taking), age and education of the entrepreneur, and the international entrepreneurial business venture (IEBV) start‐up decision.Design/methodology/approach – Data were collected from a sample of 539 individuals from dynamic internationally focused South African firms. Since the dependent variable is non‐metric and the independent variables associated with the IEBV new entry decision are metric, multiple discriminant analysis was used to test new entry decisions.Findings – Results indicate that the start‐up decision is positively related to the proactiveness and risk‐taking components of an entrepreneurial orientation and the age of the lead entrepreneur and negatively related to the education of the lead entrepreneur. As predicted, the innovativeness component of entrepreneurial orientation is not a factor in the start‐up decision.Practical implicatio...


Does The BMJ 's editorial team have any sense of irony or any understanding of how ordinary human beings (from Hull not Hampstead, to paraphrase Labour's Andy Burnham) think or behave? Is the stuff they peddle in the 18 June issue a cunning plot to get doctors to vote for Brexit? Doctors are human beings and enjoy being …


We implemented an existing parallel First-Fit graph coloring algorithm using JCSP in Java and present the results of its execution on a 32 core machine. An average speedup of 12.31 was observed with 32 cores and 140 parallel CSP processes as compared to the sequential execution. The algorithm was found to perform best when the number of processes exceeded the number of cores by an order of magnitude. On a four core laptop computer a peak performance was found for a graph of 2000 nodes and 999001 edges when between 128 and 256 parallel processes were used. Some properties of the implementation were checked using the Java PathFinder model checker, which detected a bug.


Hydropower infrastructure represents a major driver of habitat loss and insular fragmentation worldwide, mostly across the tropics and sub‐tropics. Despite growing evidence of dam‐induced impacts on biodiversity, the effects of insular habitat fragmentation on species assemblages remain poorly understood, particularly for East Asian vertebrates. Here, we assess how insectivorous bats respond to forest fragmentation in Thousand Island Lake, a mega‐hydroelectric dam in East China. Bat assemblages were surveyed across 36 land‐bridge islands of different sizes and degrees of isolation, using AudioMoth recorders. Echolocation calls were classified into sonotypes, each corresponding to either single or multiple species, which were further classified according to their habitat affinities into forest or open‐space foragers. Based on 22 875 five‐min recordings from 108 detector‐nights, we recorded 15 bat sonotypes, eight of which we classified as forest sonotypes (2329 bat passes) and seven as open‐space sonotypes (52 277 bat passes). Overall, sonotype richness increased with island area, but only above a certain threshold (34 ha). Habitat affinity played an important role in ensemble‐level responses to fragmentation; forest sonotype richness increased with island area, whereas open‐space sonotype activity was higher in more isolated islands. Our results highlight the relevance of particularly large fragments (>1000 ha) to maintain area‐sensitive forest bat species. However, islands below 34 ha in size and those more isolated from the mainland are also of conservation value as they, correspondingly, harbour a variable (but substantial) number of species and concentrate higher activity of open‐space foragers. These findings further demonstrate that acoustic sampling methods, as the one presented here, are able to provide key information for evidence‐based policies aimed at halting the ongoing wave of dam‐induced biodiversity loss.


The utility model relates to a soil ecological side slope suitable for serving as a side protecting slope of a river or a canal. Plant seeds are sowed on the basic surface of the soil ecological side slope, a grass planting blanket layer anchored on the soil ecological side slope is covered on the plant seeds, a tamping groove capable of fixing a grass planting blanket in the grass planting blanket layer is arranged at the top of the soil ecological side slope, the upper end of the grass planting blanket is paved in the tamping groove, and original soil or planting soil is tamped into the tamping groove. By means of the soil ecological side slope, the rainwash-resisting capacity is improved, water and soil loss of the soil ecological side slope is reduced, the service life of the soil ecological side slope is prolonged, the water quality of the river or the canal or a lake is improved to some extent, the windproof, sunburn protection and soil-moisture-retaining effects are played to some extent, the survival rate of the plant seeds is improved, the sowing amount of the plant seeds is decreased, the construction and maintenance cost of the soil ecological side slope is reduced remarkably, and the cost performance is high.


Objective:To observe the protection of acupuncture on hippocampal neurons injury in rats with epilepsy induced by pentylenetetrazol.Methods:72 SD rats were randomly divided into the epilepsy model group,the acupuncture treatment group and the normal group.Rats of normal group were intraperitoneally injected with the 2 mL of normal sodium.The rest of rats were intraperitoneally injected PTZ with 50 mg/kg.At 4 h and 24 h after injection,the 2 time periods of rats brain tissue were observed under microscope and electron microscope to get the message of changes in the hippocampal formation.Results:At 4 h after seizure,rats hippocampal neurons injury was seen under microscopy and electron microscopy.At 24 h after seizure,the injury was further,hippocampal neurons injury was significantly reduced in acupuncture group.Conclusion:Acupuncture has obvious protective effect of epilepsy secondary to neuronal damage.


Of all winter sports, none is so widely watched and commented upon by the media as figure skating, which is often considered the Winter Olympics' centerpiece. This critical text examines the ways in which media attention has gradually altered and affected the sport, from the early appearances of Sonja Henjie, skating's gradual audience growth via television, and the ramifications of the scandals in the 1994 and 2002 Olympics. The topic is illuminated by more than 30 interviews with commentators, skaters, producers, directors and others. In addition to numerous photos, illustrations show the compulsory figures for which "figure skating" got its name, as well as a sample of the charted-out "camera blocking" for TV directors. Appendices include collected anecdotes from early broadcasting experiences; a profile of broadcaster Jim McKay; and commentary on Carol Heiss' 1961 musical Snow White and the Three Stooges.


Abstract To improve the stability and smoothness of bionic lower extremity exoskeleton walking gait, the elitist mechanism was introduced to enhance the diversity and improve the search ability of the optimal solution. The simulation analyses showed that the improved bacterial foraging algorithm had higher convergence accuracy, and was not easy to fall into local extremum. The improved foraging optimization algorithm was used for the optimization of the bionic lower extremity exoskeleton gait zero moment point stability margin. The simulation results showed that the optimal gait planning method proposed can increase the stability margin and ensure the stable and smooth walking.


Purpose
This paper aims to examine a moderated mediation model for answering how and why work meaningfulness influences career satisfaction through job embeddedness as an intervening mechanism. There is also an investigation of how work-based social support from supervisors and co-workers are contingent upon such effect.

Design/methodology/approach
Data were collected from 1,137 accountants in various disciplines from one of the largest corporations in Thailand, including its numerous subsidiaries and joint ventures. The hypotheses were tested and analyzed by means of structural equation modeling, hierarchical regression and a bootstrapping procedure.

Findings
The results reveal that the direct relationship between meaningful work and career satisfaction was partially mediated by job embeddedness. Perceptions of supervisor and co-worker support were found to have moderating effects on meaningful work and job embeddedness. However, the conditional indirect effect was only confirmed for supervisor support.

Research limitations/implications
The generalizability of the findings may be narrow due to the nature of the sample, which involved only one occupation. Future research may expand the generalizability by considering different vocations, business contexts and industries.

Practical implications
This study offers important implications to researchers and practitioners by highlighting that an integrative model of organizational factors should be considered in managing human resources.

Originality/value
This research is among the initial attempts to extend relevant knowledge in the fields of meaningful work and job embeddedness by identifying organizational mechanisms that amplify the structural relationship.


The paper describes general calculation theory and elasticplastic behavior of cables - bearing elements of suspension structural systems. It is mentioned that this theory is based almost on the same assumptions as the theory of cable calculation at behavior of material in elastic range, excluding additional supposition in the part of idealization of real dependence between stresses and deformations on account of difficulties with using the latter in actual structures design. For that reason, this dependence is replaced with a model in the form of analytic curve or, as it is accepted to say in this case, a diagram, which is built according to some simple mathematic rule, reflecting element behavior conditions and characteristics of its material. It is stated that four main models of material behavior are used in practice: elastic-plastic, elastic-plastic with linear hardening, rigid-plastic and rigid-plastic with linear hardening. Conditions of occurrence of plastic deformations in all behavior stages of cable cross section are determined. Interrelations for geometrically and physically nonlinear task of the cable at active loading are provided. Methods are given and limit values of loads acting on the cable are determined. Equations defining parameters of cable deflected mode in all deformation phases and conditions of changing phases of cable behavior are given.


The article deals with topical issues of development of the world and the Russian economies during the post-crisis period. Some expert opinions on the world geopolitical and regional socio-economic development are given. The author presents the forecasts of GDP growth of economically leading states at present and in future and the forecast of power consumption for a long-term period. Parameters of strategic development of the Russian Federation"s resource regions are defined. The author makes suggestions on complex socio-economic development of the Irkutsk region on the basis of combination of development processes of mineral and raw material resources, rational nature management, modernization and industrialization of economy and social and political spheres of the society.


THE doctrine of isostasy has been tentatively accepted by many working geologists. It finds application in various departments of geology, but nowhere more conspicuously than in glaciology. Without passing judgment on the doctrine, and without attempting to restrict the field of its application, attention is called to a misapprehension to which it has given rise. This misapprehension is widespread in the popular mind, and has even found a foothold among those who have given attention to glacial


The term digital divide refers to the gap between people with effective access to digital and information technology and those with very limited or no access at all. There many imbalances in many sociological variables between these two groups, the most important dimensions are the income, profession, education, gender and age. The biggest gap in the Internet access are the age and to belonging to a different generation. According to [3] it is very hard to bridge this gap, the pensioners have the lowest Internet access, young people use Internet ten times likely than a oldest ones. One third of the 25 years or younger use the Internet, while only 3 percent of 65 years old or older. Of course we can assume, that the differences according to the age became smaller, because the Internet generation get pensioner in the future, too. At the spring of 2009 we made a survey in senior citizen clubs of Debrecen, Hungary. We inquired that that they know about Internet and do they use Internet, or they would learn that if they would have free opportunity. Moreover we asked them about their credit and debit card usage habits, too. In this article we present the results of the survey and try to find the reasons of protest of pensioners.


There are many diseases associated with lungs or thoracic cavity and the diagnosis of these diseases at once becomes difficult for any medical profusion. The most common way of screening done when the thoracic cavity comes into the picture is Chest Radiography. However, diagnosing multiple diseases from a single scan becomes difficult. This paper proposes an intelligent machine learning-based model which tries to detect 14 chest diseases out from a single radiograph with greater accuracy. This paper makes use of advanced deep learning techniques like neural networks, masking algorithms, etc. to assure higher performances.


Since inherent or acquired cellular resistance to various pro-apoptotic treatments often leads to therapeutic failure,a better understanding of alternative non-apoptotic pathways may facilitate the design of novel therapeutics against malignant cancer cells.Paraptosis is a cell death mode characterized by extensive vacuolization that arises via dilation of the endoplasmic reticulum(ER)and mitochondria,without any apoptotic characteristics.We found that curcumin,dimethoxycurcumin(a more stable analog of curcumin),and celastol kill malignant cancer cells via induction of paraptosis as a main cell death mode.Study on the underlying mechanisms of paraptosis revealed that simultaneous proteasomal inhibition and mitochondrial Ca2+ overload can effectively induce paraptosis in cancer cells.Mitochondrial Ca2+ overload can be achieved not only by inhibition of mitochondrial Na+/Ca2+ exchanger but also by IP3 receptor-or ryanodine receptor-mediated release of Ca2+ from the ER and its subsequent mitochondrial Ca2+ uniporter-mediated Ca2+ influx into mitochondria.Since malignant cancer cells are more vulnerable to oxidative stress and ER stress than normal cells,clarification of the molecular basis of paraptosis that targets mitochondria and the ER at the same time may provide a rational therapeutic strategy for effectively killing resistant cancer cells.