Summary Background: We aimed to evaluate the sociodemographic factors related to enuresis among children admitted to our outpatient Pediatrics clinic. Methods: The data collected from the parents of 131 enuretic children were evaluated. The patients were evaluated regarding gender, age at admittance, family history of enuresis, accompanying illness, depth of sleep, treatment type, and the socioeconomic status of the family. Results: Eighty-six patients (65.6%) were males and 45 (34.4%) were females. We could not determine any difference between two genders regarding the age at admittance. Thirty-four cases (35.1%) were found to have secondary enuresis. Positive maternal, paternal and parental history for enuresis was found among 23 (11.3%), 37 (32.2%) and 7 (3.6%) patients, respectively. Fortyfour (22.8%) and 67 (34.7%) patients were found to have positive history for enuresis among siblings and relatives, respectively. Before admittance, 22 (16.7%) patients were found to be treated with a medication and 5 (3.8%) with water restriction. Regarding accompanying disease, 4 (3.05%) patients were found to have spina bifida, 15 (11.4%) constipation, 31 (23.7%) a history of urinary tract infection, and 3 (2.2%) vesicoureteral reflux. Conclusion: Every child with enuresis should be systematically evaluated because of possible accompanying organic disorders. Education of the parents regarding the curable nature of the disease and the early treatment of newly diagnosed patients should be encouraged.


Background: The short duration of action of mivacurium is due to its rapid hydrolysis by plasma cholinesterase (pChe). In patients with normal phenotype, low pChe activity because of, for instance, disease or intake of drugs may prolong the duration of action of mivacurium. The purpose of this study was to evaluate the relationship between pChe activity and the duration of action of mivacurium 0.2 mg/kg in phenotypically normal patients.


A novel 11C–C bond formation based on the palladium-mediated cross-coupling reaction of alkenylzirconocenes with [11C]methyl iodide is described. The conversion of internal alkynes into the corresponding alkenylzirconocenes followed by transmetalation with Pd(PPh3)4 and subsequent cross-coupling with [11C]methyl iodide gave several 11C-labelled α,α′-dimethyl-substituted alkenes. The palladium complex Pd(PPh3)4 proved to be superior to Pt(PPh3)4 or Ni(PPh3)4 as transition metal complex.

The scope and limitations of the novel palladium-mediated cross-coupling reaction of alkenylzirconocenes with [11C]methyl iodide were tested with various internal alkynes. After heating at 60°C for 6 min radiochemical yields of up to 75% (based upon [11C]methyl iodide) could be achieved. Copyright © 2006 John Wiley & Sons, Ltd.


Prostate cancer is one of the most common lethal cancers in men in the developed countries. In the USA, it is estimated to affect 161,360 men (19% of all the newly diagnosed cancers) with an estimated mortality of 26,730 men (8% of all cancer deaths) in 2017. This renders it the most commonly diagnosed cancer and the third most common cause of cancer death in the USA in 2017 (1). Prostate cancer is an unique malignancy in that most of patients die with and not because of it (2).


eligible to citizenship has correspondingly shrunk the group ineligible under the provisions of the alien land law to own or lease land in California until the latter now consists in reality of a very small number of Japanese. The other Asiatics who still remain on the proscribed list are so few that they need not be considered. Clearly such a discrimination against a people of one race is contrary both to the letter and to the spirit of the Charter which, as a treaty, is paramount to every law of every State in conflict with it. The alien land law must therefore yield to the treaty as the superior authority. The restrictions of the statute based on eligibility to citizenship, but which ultimately and actually are referable to race or color, must be and are therefore declared untenable and unenforceable.


Objective To compare the results of the two kinds of serodiagnosis in detection of Treponema pallidun infection,and to explore the clinical significance of Treponema pallidum particle agglutination (TPPA) assay combined with toluidine red unheated serum test (TRUST).Methods Treponema pallidun antibody was detected in 1,003 serum samples collected from outpatients and inpatients of The First People's Hospital of Chenzhou from January to December,2009 by TPPA assay and TRUST,and the detection results of the two methods were compared and analyzed.Results There were statistically significant differences in positive rate between TPPA assay (41.87%) and TRUST test (22.53%),(P0.01).Conclusions The specificity of TPPA assay is superior to that of TRUST test,which could be considered as the confirmatory test on Treponema pallidun infection.TRUST could be considered as a detection indicator of relapse and re-infection of Treponema pallidun.Combination of the two tests in diagnosis of Treponema pallidun infection could improve the monitoring of Treponema pallidun and control the prevalence of Treponema pallidun.


Nowadays, timely completion of the project has become a crucial part in the construction industry. The responsibility of cities is to mobilize in order to improve housing circumstances in slums as a medium of meeting fundamental human needs. Slum areas are highly populated regions created without adequate planning and lacking the key elements of day to day life. The slum rehabilitation is a critical project for any contractor or owner. Generally, consistent delays in the project show up in the preplanning and initial stages of the construction projects, for example, getting the general plans, getting the license, permissions, various legal clearances and so on. The complete construction stage is the shaping phase of any project where numerous unforeseeable events could occur. Lack in determination of the delay factors in the slum transformation project would contribute to the project delays, schedule overrun and capital overruns. This study aims to recognize the possible challenges faced in the construction of a slum rehabilitation project. This study classifies delay factors of the project in different stages i.e., pre-planning and construction stage and proposing a better type of approach to overcome delay related challenges in slum rehabilitation construction project.


Summary form only given. Finding acronyms and their definitions in free text is useful for many purposes. We have developed a new method that uses several PPM models to encode the acronym in terms of its definition. Four different attributes of each acronym are encoded using a PPMD order 5 model: (a) whether the acronym occurred before or after its definition (direction); (b) the distance between the acronym and the definition (first-word offset); (c) the pattern of words in the definition with letters in the acronym (subsequent-word offsets); and (d) the number of letters taken from each of those words. These models, taken together, give a complete encoding of the acronym in terms of its definition. The models were trained on 1080 acronyms extracted from 150 documents. A model of plain text was trained using 100 independent documents from the same collection.


The purpose of this study is to identify the relationship between leadership style, organizational culture and organizational effectiveness.  In this study independent variables are leadership style and organizational culture.  Here the leadership style was discussed based on the transformational and transactional leadership model.  Elaboration of organizational culture was based on competing values model which is one dominant typology and also it has become a popular and validated framework.  Thus, the dependent variable of this study, organizational effectiveness was discussed based on the competing values model.  Based on the literature, the study found that there is a positive impact on leadership style on organizational effectiveness as well as there is a positive impact of organizational culture on organizational effectiveness.  Further, as the literature, the study found that impact of leadership style on organizational effectiveness was moderated by the organizational culture.


Aiming at the problem of modeling and compensation of the fiber optic gyroscope (FOG) drift caused by temperature, a novel compensation method for FOG temperature drift based on transformed unscented Kalman filter (TUKF) is proposed. Elman network with faster convergence speed is used to modeling and TUKF algorithm is adopted to train the weights of Elman network, which effectively solves the problem of numerical instability. The results prove that the proposed method has higher precision compared with Elman network and IUKF network models. By using the TUKF algorithm, the root mean square errors (RMSE) are improved by 60% in temperature rise period and 50.5% in fall period.


Today the term big data draws a lot of attention. Big data is the new technology that enables an organization to take advantage of the natural resource of big data. Organizations store up huge amounts of information, they can mine those databases to discover subtle patterns, correlations, or relationships that human brains can't perceive on their own because the scales involved are beyond our ability to process. Big data is a hot topic in the market today and attracted a lot of attention from retail, automotive, and manufacturing industry, government as well as academia. This paper introduces several enhancements in big data over data mining and relational database. Finally, I discuss the urgency of big data processing in cloud computing environments.


The institutional performance of zakat management has a very significant position and function toreduce poverty. Theologically, zakat is believed by Muslims to reduce poverty. However, zakat management institutions are practically paying less attention to the existed rules and governance of institutional development. As a result, zakat institutions tend not to be positioned as social financial institutions.
This study seeks to place the institutional management of zakat as a social financial institution in Islam. By placing this view, this study measures the institutional management of zakat using the National Zakat Index (NZI) approach. Sampling in this study using convenience sampling techniques. The analytical tool applied in this study is the National Zakat Index (NZI) with a calculation method called the Multi-Stage Weigh Index. The object of this research is the zakat institution in West Nusa Tenggara Province, by comparing zakat institutions at the provincial and district levels.
The results of this study found a national zakat index in different micro dimensions, where the BAZNAS of the NTB Province obtained a value of the micro dimension of 0.80 which means that the institutional performance was good and LAZ DASI NTB received a value of the micro dimension of 0.81 which means that the performance of the institution was very good. While the comparison of performance at the Baznas at the Regency level, it is known the value of the micro dimension in West Lombok Regency BAZNAS is 0.57 which means its performance is quite good and at BAZNAS the City of Mataram obtains the value of the micro dimension of 0.72 meaning that its performance is good. The results of this study confirm the importance of strengthening and developing zakat institutions and the revitalization of NZI as a measure of the effectiveness of zakat institutions.


Cervical spondylosis is one of the most common degenerative conditions of the spine. It is caused by the degeneration of cervical intervertebral discs, osteophytosis of vertebral bodies, hypertrophy of the facets and laminal arches, and ligamentous and segmental instability. Risk factors are Age, occupation, genetics, previous injury or trauma. The main complaints are pain in the head, neck and shoulder with corresponding tenderness, sometimes radiation and decreased cervical range of motion. Conventional treatment for cervical spondylosis includes pharmacological and non-pharmacological modalities. All these treatment modalities have a range of effects and their availability is meagre and cost over burdened. Hijamah is a Unani regimenal mode of treatment which has been proved effective in various musculoskeletal disorders. In present paper efforts has been made to elaborate the role of Hijamah in the management of cervical spondylosis and to correlate its mechanism with other physical therapies like traction and message therapy, ultrasound and diathermy.


In this paper we present an algorithm for low-cost hardware antialiasing and transparency. This technique keeps a central Z value along with 8-bit floating-point Z gradients in the X and Y dimensions for each fragment within a pixel (hence the name Z 3). It uses a small fixed amount of storage per pixel. If there are more fragments generated for a pixel than the space available, it merges only as many fragments as necessary in order to fit in the available per-pixel memory. The merging occurs on those fragments having the closest Z values. This combines different fragments from the same surface, resulting in both storage and processing efficiency. When operating with opaque surfaces, Z 3 can provide superior image quality over sparse supersampling methods that use eight samples per pixel while using storage for only three fragments. Z 3 also makes the use of large numbers of samples (e.g., 16) feasible in inexpensive hardware, enabling higher quality images. It is simple to implement because it uses a small fixed number of fragments per pixel. Z can also provide order-independent transparency even if many transparent surfaces are present. Moreover, unlike the original A-buffer algorithm it correctly antialiases interpenetrating transparent surfaces because it has three-dimensional Z information within each pixel.


The SERC's engineering design initiative, launched as a result of the 1984 Lickley Report, aims to increase the amount of SERC-funded research directed at the needs of designers in industry. This article reviews the role of the initiative in promoting research in engineering design.


Availability of high-voltage power modules based on silicon carbide (SiC) is enabling the realization of multilevel topologies to solve a variety of issues in power distribution systems. However, the relatively low voltage ratings of currently-available semiconductor devices increase the complexity of the required solutions. Stacking lower-cost and lower-voltage devices to derive a higher-voltage switch can help reduce system complexity at the expense of more a complex switching position. Thus, this stacking solution comes with its own set of challenges. This paper presents the design and experimental results for an 11-level 13.8 kV neutral-point-clamped flying-capacitor converter that uses stackable switching positions for three-phase current compensation in a distribution system. The converter is successfully used for direct grid-connection and upstream current compensation with a 4.16 kVLL grid.


Abstract. This study focuses on aspects of the behavior of managers in the financial sector towards the tendency to create budgetary slack with research variables controlling the budget, budgetary slack and short-term managerial orientation. Researchers are interested in budget control and budgetary slack because these two variables are a characteristic of budgeting. This study aims to determine whether there is an effect of budget control on budgetary slack and to find out whether there is an influence between budget control over short-term managerial orientation in the 3 service agencies in the city of Bandung. Data sources in this study use primary data sources with data collection techniques the questionnaire used. The technique of determining the sample in this study used non-probability sampling techniques by saturated sampling, the number of samples was 35 respondents in the Education Office, the Transportation Agency and the Service of the Civil Service Police Unit. The statistical technique used in hypothesis testing is simple linear regression analysis. The results showed that budget control had an effect on budgetary slack, and budget control had an effect on short-term managerial orientation at 3 official institutions in the city of Bandung. Keywords: Budget Control, Budget Slack, Short Term Managerial Orientation


Following in the footsteps of Deleuze, after classic-cinema's moving image and modern cinema's time-image, the author attempts to lay down the criteria for the absence-image of post-modern cinema. A vacuum that leads to the absence of meaning, and to the cessation of feeling. A tug-ofwar between the material and the spiritual world that summons bodies and ghosts at the same time. This concept was illustrated in the most radical films of the time (Gus van Sant, Tsai Ming-liang, Claire Denis) and surprisingly, in commercial films (M. Night Shyamalan, Jared Hess). Both are polarized extremities, yet they both lead to extreme cinema


Treatment of family Icacinaceae flora Venezuela is presented. The family includes nine genera and 21 species in the country. The most diverse genus is Emmotu...


Slope stability of different waste containment systems is a matter of serious concern due to its impact on air, land, and water pollution, affecting human and aquatic lives. It has been observed that most of the waste containment slope failures are translational failure. In this chapter, the slope stability analysis of the waste containment is discussed with translational failure (wedge analysis) in single and multiobjective optimization framework using genetic algorithm (GA). Non-dominated sorting genetic algorithm II (NSGA-II) is found to efficient in developing the Pareto front in terms of factor of safety (FOS), height of embankment, and volume of the failed slope. The FOS decreased with increase in height of the slope and the volume of the slope also increased. The optimized slope in terms of different slope angle and with seismic coefficients is also discussed. Such a study will help the professional in deciding the height of the slope as per the FOS in a specified seismic zone.


Magnetic resonance imaging can cause fear and anxiety for children, which depend on the environment and the children's lack of understanding and communication. It is also very important to lie stil ...


This paper deals mainly with the following question: does the distribution area of a monophyletic unit (and firstly of a species) have some reality or is it simply the spatial representation of its occupant? If the species is an individual-like entity, having ontological and genealogical properties, and interacting with the environment as such an entity, then it grants the status and reality of distribution area to the fraction of physical space it occupies, and the distribution area itself has the same ontological and genealogical properties of the species. According to this viewpoint, since the species can be viewed as the largest succession of eidophoronts (= bearers of the image) linked by exclusive genealogic (tocogenetic) relationships, the distribution area (of a species) can be considered the largest succession of nemophoronts (bearers of places) linked by exclusive ancestor-descendant relationships. Such a theoretical approach allows us to build Steiner trees representing hypothetical relationships between distribution areas, which are independent of any hypothesis about organism phylogeny and geographical history. A methodological procedure is also proposed and discussed by means of the analysis of a Mediterranean genus of Coleoptera.


by Joseph R. Geary In-situ sensing of pathogens of concern in waters is a need for water monitoring agencies. The unpredictable, rapid fluctuations in indicator organism (Escherichia coli— EC) concentrations renders current standards and methods both untimely and unrepresentative of the water body as a whole. The use of glucuronides with a fluorescent label allows EC detection by identifying ß-glucuronidase (GUS) expressed through EC's natural metabolic processes. This activity can be quantified in a stop-flow sensor and correlated via a quantification curve back to initial EC concentrations. A fluorescent labeled glucuronide that is soluble and highly fluorescent at natural water pHs is also necessary. The current lack of understanding of the factors that influence GUS synthesis and expression in natural waters is addressed in this dissertation. The information presented here increases the accuracy of an in-situ optical sensor. This dissertation reports for the first time the Michaelis-Menten kinetic parameters of GUS using the substrate Carboxyumbelliferyl-ß-D-glucuronide (CUG) as Km=0.910, Vmax = 0.041, Vmax/Km 0.045 mM min; optimal pH is 6.5±1.0; optimal temperature is 38 ̊C; CUG hydrolysis is not significantly affected by heavy solvents


This article shows Static structural analyses performed on 35 different Superadobe domed models. The dimensions of these models were defined according to a controlled variation of initial parameters, guided by previously derived equations. Maximum and Minimum principal stresses, Shear stresses and total deformations were measured assuming an idealized material with isotropic elasticity. Besides the dome's self-weight, wind loads are considered from the most dangerous angle with respect to the openings.


Objective: Childhood obesity seems to be increasing at alarming rates worldwide, including Greece. The aim of this study was to determine the relationship of obesity with the presence of high blood pressure (BP) in a sample of Greek children. Design-Methods: This is a cross-sectional, school-based study conducted in seven schools in Eastern Attica, the greater area of Athens. Students were subjected to anthropometric and BP assessment according to the International Obesity Task Force references and the guidelines of the 4th Report on the Diagnosis, Evaluation and Treatment of High Blood pressure in children and adolescents respectively. Results: 780 students (9.2 ± 1.8 years old, 415 boys) were included in the analysis. Approximately 22% of the participants were overweight and 8% obese. The prevalence of high BP in the range of prehypertension and hypertension was 17% and 26% respectively. Overweight and obese children compared with normal-weight children had higher BP levels (108.3 ± 11.8/71.7 ± 9.5 mmHg systolic/diastolic vs. 105 ± 11/69.8 ± 9.7 mmHg respectively, p < 0.05 for both comparisons). In multiple regression analysis with age, gender and body mass index (BMI) as independent variables, BMI was associated with higher levels of systolic BP (β = 0.496 ± 0.106, p < 0.001) and diastolic BP (β = 0.227 ± 0.09, p = 0.02), independently of age and gender. Conclusions: High rates of childhood overweight and obesity were recorded in this study population. Moreover, the presence of overweight/obesity was related to increased levels of BP independently of age and gender. Taking into account that these parameters are associated with an increased risk for cardiovascular events, the need for preventive measures against childhood obesity emerges urgently.


Introduction: Fine needle aspiration cytology (FNAC) is a simple, economical and relatively accurate procedure for initial diagnosis of all superficial lumps. It plays an important role as an early investigation in the management of patients with lymphadenopathy. This study was aimed to evaluate the role of FNAC in patients presenting with lymphadenopathy. Material and methods: The Present study was conducted in the Cytology section of the Postgraduate Department of Pathology, Govt. Medical College Jammu over a period of 1 year. Patients presenting with superficial palpable lymph nodes were included in study. Material was aspirated with 22 gauge needle and smears were prepared. Smears obtained were stained by May-Grunwald-Giemsa and Papanicolaou methods and examined. Results: The most common cause of lymphadenopathy in males was found to be reactive lymphadenitis (37.93%) followed by tuberculous lymphadenitis (27.59%). In females most common cause of lymphadenopathy was found to be tuberculous lymphadenitis (38.09%) followed by reactive lymphadenitis (35.71%). In the elderly age group (> 45 years), metastatic carcinoma was found to be most common cause of lymphadenopathy (43.33%). Conclusion: Fine Needle Aspiration Cytology (FNAC) is a useful initial diagnostic tool in evaluating lymphadenopathy. It is a simple, accurate, rapid and effective method with minimum complications.


The present investigation has as general objective to elaborate ham with addition of starches and enriched with proteins animal and vegetable, for this way to be able to take advantage of the matters existent cousins in this region and to give bigger easiness to the consumer.
This investigation was carried out in the laboratory of Agroindustries of the Superior Technological Institute Calazacon, located in the km 6 ½ of the Sacred road Domingo - Quevedo, in the Sacred Canton Domingo of the county of Sacred Domingo of the Tsachilas.
For the development of this work a factorial experiment was used (AxBxC) under a design in totally aleatory blocks with 8 treatments and 3 repetitions, the averages of the results were subjected to the tukey test to 95% of trust, the studied factors were: the factor TO (percentages of meats), Factor B (types of starches) and factor C (types of proteins) each factor with two levels.
In the development of the investigation you proceeded to carry out the reception, heavy and cleaning of the matter prevails, then you troceo in small pieces to facilitate the one milled of the meat, it was weighed again, you proceeded to weigh the preservatives, the meat was placed milled together with the preservatives until obtaining a homogeneous pasta during 5 minutes, you proceeded to stuff the mixture in a synthetic gut of 12 cm of wide, then it was pressed during 15 hours I lower refrigeration, he/she cooked for 2 hours with temperatures from 70oC to 85oC, we cool with water freeze it was packed and it stored in refrigeration.
Once carried out all the treatments of the hams underwent an analysis proximal and an evaluation organoleptica, for both cases they got ready small samples packed to the hole, the analysis proximal was carried out it in the Laboratory of Chemistry of the UTE, headquarters Saint Domingo with the purpose of determining the pH percentage, humidity, ash, fat and protein, the yield analysis and the balance of materials was made in the laboratory of Agroindustries of the Superior Technological Institute Calazacon and the evaluation organoleptica was carried out it with a panel of degustadores of the same institution, with the purpose of to determine which treatment is the one that has more acceptability for the consumer.
After having subjected to all the treatments to an analysis of their technical parameters, besides the results of the evaluation organoleptica you reached the conclusion that the most acceptable is the treatment 6, the same one that contains in their formulation 70% of chicken meat and 30% of pig meat, 2% of yucca starch and 1% of soya protein. He fits to mention that the cost of production of 1 kg, of this treatment is of $10,72; the price of sale of each package of 250 gr. of $3,50 the benefit with relationship at the cost is of $1,17.
It is recommended that the appropriate levels of percentages of meats to elaborate hams of good characteristics for the consumer are those that have 70% of chicken meat and 30% of pig meat and the type of more appropriate starch is that of yucca starch and the protein that better results gave the soya protein.


Credit and interest rate risk in the banking book are the two most important risks faced by commercial banks. In this paper we derive a consistent and general framework to measure the riskiness of a bank which is subject to correlated interest rate and credit risk. The framework accounts for all sources of credit risk, interest rate risk and their combined impact As we model the whole balance sheet of a bank the framework not only enables us to assess the impact of credit and interest rate risk on the bank's economic value but also on its future earnings and capital adequacy. We apply our framework to a hypothetical bank in normal and stressed conditions. The simulation highlights that it is fundamental to measure the impact of correlated interest rate and credit risk jointly on the whole portfolio of banks, including assets, liabilities and off-balance sheet items


This paper puts forward a treatment method of emulsified oily wastewater by using fiber ball. Feasibility of using fiber ball as absorbent to deal with hot-stripped dirty recycled wastewater of steel industrial was validated. Sorption isotherms and FreundLich equation of fiber ball were obtained during absorption experiment in laboratory, and the mechanism was discussed to provide basis theory for its industrial application.


As the Internet develops faster, it has also become more useful. Many Chinese Internet users utilize online tourism and travel services for vacation and travel. To evaluate the prevalent online tourism and travel service providers, this paper selects five of the most popular providers in China, including Ctrip, Qunar, Kuxun, Taobao Travel and eLong. Five-star rating approach is adopted in the evaluation process. Some purchasing experience criteria of are summarized from the users' perspective, such as product variety, price comparison, customer reviews, customer service and mobile APP. Based on the total ratings, statistical analysis is used to explain the final results.


Introduction: A key goal of volatile measurements in lunar samples is to determine the initial volatile compositions and abundances of their parental magmas. Lunar basalts are particularly important as they form through partial melting of the lunar mantle, and can provide information about volatiles in their respective mantle sources. Most sample-based studies of volatiles in lunar rocks have focused on the common accessory mineral apatite [Ca5(PO4)3(OH,F,Cl)] (e.g., [1,2]). Apatite can preserve information about volatile abundance and isotopic composition, but it can only be used to infer magmatic volatile abundances in specific compositional circumstances [3,4]. Measurements of lunar pyroclastic glasses [5] and melt inclusions [6,7] avoid this issue, but these are relatively rare in the lunar sample collection. Common nominally anhydrous minerals (NAMs) such as olivine, plagioclase, and pyroxene, can contain small amounts of volatiles. Volatiles enter these minerals according to simple partitioning coefficients [3,8]. We developed a technique using secondary ion mass spectrometry (SIMS) to measure volatiles in NAMs. Here, we present the first coordinated measurements of volatiles in silicates and apatite (reported in Robinson et al. [9]) in the same lunar sample.


Introduction
: Despite the progress made in perinatal medicine over the past two decades, the
problem of preterm labor continues to frustrate satisfactory reproductive outcomes and its prevention
still awaits needed improvements. Several factors have been identified to be associated with preterm
birth (PTB).


India is one of the major economies of the world and is growing by leaps and bounds with constantly been reminded as one of the world's strongest economy.From being a socialist economy for almost 4 decades to transforming to one of the prominent global players, India has gone through a lot in last few decades since 1991. The LPG in 1991 is the root cause for all many transitions in Indian economy. Post-1991 India has grown tremendously and has developed its own economic system in par with the world's economic systems thus making India a super power in world markets.  Though India has been quoted as one of the best performing marketsin the world still Indian markets share in world market capitalization is at its low. As per the reports of times of India in 2017 India's share in world market capitalization is at around 2.5%. The reasons for this are multiple one being investors non-preference tocapital market investments. This is due to the information asymmetry between the market players and the investors. This asymmetry can be filled by providing the potential information to the prospective investors thus persuading them to invest in capital markets. Perhaps, providing right information to the investors would improve the capital market attractiveness and helps in channelizing the funds from net savers to the Industry. The present study is based on secondary data and is an extraction from various researches conducted earlier about the growth and development of Indian capital markets. At times like this where the global markets are all on their ears for India it is quint essential to sharp the fundamentals of our domestic investors to keep them up to date. The research article is systematically studied and analyzed the various capital market instruments and their growth trends, so that the investors can take a wise decision while investing in capital markets.


some disadvantages, however slight. It is desirable, therefore, to review objectively the possible present or future consequences of increased irradiation of populations which result from these medical applications of radiation. 3. It is now accepted that the irradiation of human beings, and particularly of their germinal tissues, has certain undesirable effects. Although many of the somatic effects of radiation may be reversible, germinal irradiation normally has an irreversible and therefore cumulative effect. Any irradiation of the germinal tissues, however slight, thus involves genetic damage which may be small but is nevertheless real. For somatic effects there may however be thresholds for any irreversible effects, although, if so, these thresholds may well be low. 4. The information so far available indicates that the human race is subjected to natural radiation,' as well as to artificial radiation due to its medical applications, to atomic industry and its effluents and to the radioactive fall-out from nuclear explosions. The Committee is aware of the potential hazards that such radiation involves, and it is collecting and examining information on these subjects.


1. Stoichiometric interconversion of glutamate and aspartate by the coupling reactions between GOTM and TCA cycle takes place in the isolated mitochondrial system.2. Significance of the GOTM cycle for amino acid metabolism may concern with nonessential amino acid catabolism and anabolism and with the effective pathway, through which the amino group of glutamate turns into urea without liberation of ammonia.3. Elementary reactions of GOTM strongly occur in mitochondria, but the physiological significance is not known.


Verifying the functional behavior of graphical user interface (GUI) applications is essential for reducing post-release issues. In practice, a developer/tester performs this verification by executing a sequence of GUI actions and then witnessing the expected behavior on the GUI screen. An automated witness generator facilitates the verification process. However, creating an unambiguous and monitorable specification for the correct behavior and then generating the correct GUI actions to trigger that behavior is challenging. In this study, we propose FARLEAD2, an automated witness generator that uses unambiguous, monitorable, and easy-to-read staged test scenarios (STSs) to specify expected behavior. FARLEAD2 maximizes its effectiveness and performance using generalized experienced replay (GER) to exploit the experience gathered from previously witnessed scenarios on new, unwitnessed test scenarios. To the best of our knowledge, STS and GER are novel improvements to GUI testing. Our evaluation of Android GUI applications shows that FARLEAD2 effectively generates a witness 95.7 times out of 100 and does it in 520 seconds, on average, indicating that FARLEAD2 is approximately 65 percent faster and 6.3 percent more effective than its best predecessor.


The development of science and technology is currently growing very rapidly from time to time. the application of various existing technologies encourages the development of work efficiency and service quality in companies, government agencies, and the world of education. The development of information technology can improve performance, including employee absences. Recording employee absences is an important factor in human resource management. In-depth and detailed information about the presence of an employee can determine work performance, salary, productivity or progress of the institution in general. The Sosopan Village Office, Kotapinang District, still uses manual attendance, and therefore requires a system that can increase efficiency, including what will be made, namely Arduino-based Employee Attendance RFID, attendance is only for data that has been registered. The purpose of this research is to make it easier for every employee. office and help the admin to record every attendance.


: Background & aim: The human living environment should be designed in accordance with his physical, mental and physical condition, so that no pressure or harm is inflicted on him. Also, if you give them any, all, or all of them, they will cause musculoskeletal disorders. Therefore, the purpose of the present study was to determine and evaluate the ergonomic status of workstations in Gachsaran health center. Methods : The present descriptive qualitative study was conducted in 2019. The study population included the staff of Gachsaran health center from which 10 people were selected. A non-random purposive method was used to select participants in the study. This continued until data saturation, the data collection tool being a semi-structured interview. In order to analyze the data, the latent content analysis method was used. Results: The findings led to the extraction of the main themes of ergonomic health center status and 5 main themes; workstations comprising 16 proprietary codes, ergonomic knowledge comprising 7 proprietary codes, musculoskeletal disorders comprising 18 proprietary codes, organizational performance comprising 13 proprietary codes, and realization barriers comprising 8 codes. Became dedicated. Ergonomic knowledge includes the awareness, attitude and behavior of individuals. Orumi implementation is implemented in a system when all users of the system with the necessary ergonomic knowledge can be implemented in the principles of an organization, users of that system suffer from work-related injuries and diseases, are satisfied with the conditions of the workplace. One of the factors that can be understood in the principles of ergonomics in the workplace. Conclusion : Workstations, ergonomic knowledge, musculoskeletal disorders, organizational performance and barriers to the realization of five themes were identified in the present study. It is suggested that managers change their attitude toward ergonomics while developing a workstation evaluation program to provide effective interventions to improve workstations. As well as practical training in providing employees with ergonomic principles.


Coronary artery fistulae are abnormal communications between the coronary arteries and adjacent structures. They include abnormal communications between the coronary arteries and cardiac chambers, referred to as coronary cameral fistulae or abnormal communications between the coronary arteries and other vessels referred to as coronary arteriovenous malformations.Most coronary artery fistulae are small, asymptomatic, do not cause any complications, and resolve spontaneously. Large fistulae, however, may cause symptoms and complications.Its site of origin and termination describes each fistula. A fistula originating from the right coronary artery draining into the right ventricle is the most common type of coronary artery fistula. Most fistulae terminate into the right ventricle or the right atrium. Rarely do they terminate into the left atrium or left ventricle.


Fifteen years have passed since publication of the second edition of Frank Grad's landmark text, The Public Health Law Manual (the Manual), and the timing for introducing the third edition could not be better. The public health field has faced significant tests over the past decade and a half. While our society battles infectious diseases discovered relatively recently, such as HIV, old diseases, such as tuberculosis and pertussis, have resurfaced; and new concerns, such as West Nile virus, mad cow disease, SARS, and avian influenza, have stretched the public health system to its financial and structural limits. Bioterrorism preparedness has become a focal point for the public health system in the wake of the terrorist and anthrax attacks of fall 2001. Our vaccine supplies for childhood diseases and influenza have experienced critical shortages, and a recent rash of drug recalls have drawn FDA oversight of the drug development process into question. Environmental concerns at home and globally have led to calls for broader cooperation to reduce risks such as those posed by greenhouse gases. The tobacco industry has been under intense fire in the courts and the capital, leading to the proposed "global settlement" tobacco legislation, the 1998 Tobacco Master Settlement Agreement, and subsequent tobacco control policies and missed opportunities.


This research problem is low learning achievement of students in junior high school social studies Economics Negeri 2 Habinsaran. The purpose of this study aims to determine the economic improvement of student learning outcomes VIII B grade Negeri 2 Habinsaran. After applying the learning model horay review this course.
 This research was conducted in SMP Negeri 2 HabinsaranAcademic Year 2012/2013. With the subject of the eighth grade students numbering 30 people. In data collection techniques used were the results of tests of learning and observation sheet.
 The results of this study indicate that the average pretest score before the holding action in the first cycle is 59.18 where 30% of students who meet the Minimum Criteria exhaustiveness (KKM). Having held the first cycle of action in the average score is 67.5, where 56.67% of students who have reached the KKM. And after the second cycle of action in the average value of 75.06 where 80% of students have reached the KKM. Means of research deemed to have been completed or the student has completed in achieving KKM.
Application of learning models horay review course on basic competencies to describe the relationship between scarcity of resources with human needs are not limited in the eighth grade private in SMP Negeri 2 Habinsaran Academic Year 2012/2013 can improve student learning outcomes.


Although a number of theories and principles have been developed to guide the creation of visualizations, it is not always apparent how to apply the knowledge in these principles. We describe the application of perceptual and cognitive theories for the analysis of uncertainty visualizations. General principles from Bertin, Tufte, and Ware are outlined and then applied to the analysis of eight different uncertainty visualizations. The theories provided a useful framework for analysis of the methods, and provided insights into the strengths and weaknesses of various aspects of the visualizations.


Pre-operative electroretinographic (ERG) data from 203 dogs with cataracts at the National Taiwan University Veterinary Hospital (NTUVH) were analyzed. Retinal function of the catatact dogs was examined by a RetinoGraphics ERG system with a white flash stimulus delivered to mydriatic canine eyes under general anesthesia. ERG was recorded by a contact-lens type of recording electrode referenced to a needle electrode inserted subcutaneously 3 cm posterior to the lateral can-thus. Abnormal ERG results with a wave amplitude less than 70 micorvolts were measured in 27% (109/402) of the eyes examined, including 9% (37/402) of eyes with absent responses and 18% (72/402) of eyes with decreased responses to light stimuli. Miniature schnauzer, Miniature poodle, Pomenarian, and Cocker spaniel showed significantly lower ERG b-wave amplitudes when compared to mix-breed dogs. There were no remarkable changes in the implicit time of ERG wave. There was a big difference in b-wave amplitudes between different age among dogs lost of retinal function, whereas there was no difference in gender among dogs lost of retinal function. In 73% of the dogs, ERG results were normal and cataract surgery was performed with good post-op visual prognosis achieved. As retinal diseases commonly affect dogs and the diseases greatly affect post-op visual outcome and success rate of surgery performed in cataract patients, ERG is an essential procedure before cataract surgery to select suitable candidates for surgical treatment of cataracts in animals.


Fiber optics has become the core of todays telecommunications and data networking infrastructures. Thanks to its advantageous properties like low attenuation, huge bandwidth and immunity against electromagnetic interference fiber cables are replacing existing copper cables. They have been widely deployed to realize high-speed links that may carry either a single wavelength channel or multiple wavelength channels by means of wavelength division multiplexing (WDM). The rapid evolution of technology, coupled with the insatiable demand for bandwidth resulted with the existence of two generations of fiber optic networks. Existing recovery mechanisms make optical networks fault-tolerant. Fault tolerance refers to the ability of the network to reconfigure and reestablish communication upon a failure. Usual recovery mechanisms that deal with network failures can be divided into protection and restoration. The protection mechanism activates in advance backup resource that will be used in case of failure, while the restoration mechanism takes over backup resource upon a failure; that is why protection mechanisms can recover quickly but are more demanding in terms of resource. Restoration mechanisms are less demanding when it comes to resource and therefore may be less costly than protection mechanisms in term of initial investments, but they generate longer service disruption. The goal of the work conducted during this thesis was to find a solution for technical implementation of the proactive fault detection and fast recovery in the core optical network. This dissertation outlines the different solutions and their evaluation from the point of view of the network telecommunications operator. First chapter of this thesis is devoted to reviewing the existing recovery methods in the optical networks. In order to understand this thesis it is necessary to establish the vocabulary and basic elements of telecommunications and in particular fiber-optic communications. Chapter II addresses the existing methods of prediction. This part covers the area of machine learning. Once the reader has been introduced to the typical methods for prediction, an enhanced system design is proposed. Chapter III consolidates all the previous review work to an estimation of the most promising technique for proactive fault detection. An experimental test bed using fiber as a sensor was set up and used to quantify exactly the performance of the selected solution. This requires building an advanced representation of data that was used as input data for machine learning software. The relative importance of some effects is discussed. Once a deeper understanding of the potential of this technique has been achieved with an experimental test bed, theoretical investigations through the development of analytical models are conducted to validate and generalize them. Chapter IV describes the advantages and drawbacks of this kind of detection. Simulations were made that prove the knowledge obtained using the test-bed. Later on, a case study concerning the phase of recovery in the transport network is presented.


The anthropocentric cell manufacturing system (ACMS), using a basic concept of skill-based manufacturing and integration of automation system is proposed. Manufacturing systems generally require an appropriate communication system to manage and control ACMS resources. The model of ACMS communication system composes of management, manufacturing, and new OJT unit. The proposed model is initially constructed by an application of information technologies, consisting of Visual Basic programming, JAVA RMI-IIOP, Telnet-SMTP, videoconference, RFID and a computer network. The operations of three units of the communication model, including schedule notice, manufacturing execution and new OJT training execution are designed in order to implement subsequent thirteen procedures to these communication units. An implementation of the system results in simple operation and ACMS compatibility.


—Autism is a neurobehavioral problem that hinders to interact with others. Autistic Spectrum Disorder (ASD) is a psychological disorder that hampers procurement of etymological, communication, cognitive, social skills and Stereotypical motor behaviors and capabilities. Recent research revealing that Autism Spectrum Disorder can be diagnosed using gaze structures which has opened up a new field where visual focus modelling could be highly used. Diagnosis of ASD becomes a difficult task due to wide range of symptoms and severity of ASD. Deep neural networks have been widely employed and have shown to perform well in a variety of visual data processing applications. In this paper, typical developed (TD) or ASD is classified using Convolution neural Networks (CNN) for the fixation maps of the corresponding observer's gaze at a given image. The objective of this paper is to observe whether eye-tracking data of fixation map could classify children with ASD and typical development (TD). We further investigated whether features on visual fixation would attain better classification performance. The proposed CNN model achieves 75.23% accuracy for validation.


The lust for precedence in publication is the most important dirty secret of the scientific working class. Certainly, scientists know that hasty publication may be inaccurate, or that the first announcement of a finding may at best pale before the significance of further workings and modifications of that finding. Regardless, the mental restlessness of scientists may be as much due to anguish provoked by searching Current Contents for a feared scooping, as to struggles for the next truth.


The existence of large domains of antimatter is still an open question. Some space mission and experiments in the near future are expected to give reasonable answer to that question. Meanwhile, we can try to search for other signatures of the presence of antimatter. This paper presents a discussion about possible effects of the close encounter of stars and antistars. It is known that the accretion power can be higher in presence of antimatter, because of high-energy photons generated in annihilation, which result in a smaller radiation pressure. Therefore, the Eddington luminosity can reach higher values. Calculations of the gamma-ray flux above 100 MeV, and comparison with recent data from satellites, show a good agreement for certain sources. So, let's play some science-fiction!


Objectives Methotrexate is considered to be first-line therapy for rheumatoid arthritis (RA). However, a substantial proportion of treated patients do not achieve the desired goals of therapy. This analysis aimed to identify predictors of insufficient response to methotrexate in patients with early RA. Methods The Optimal Protocol for Treatment Initiation with Methotrexate and Adalimumab (OPTIMA) and PREMIER studies in patients with RA for <1 and <3 years, respectively, examined the efficacy of methotrexate and adalimumab in methotrexate-naive patients. This post hoc analysis included patients for whom initial methotrexate monotherapy was not successful after 6 months. Candidate predictors of insufficient response and clinically relevant radiographic progression (CRRP) included demographics, baseline disease characteristics and time-averaged disease variables over a 12-week interval. In OPTIMA, adalimumab was added to therapy after insufficient treatment response; in PREMIER, initial methotrexate therapy was continued; clinical, functional and radiologic outcomes were assessed after 1 year. Results Baseline 28-joint Disease Activity Score based on C-reactive protein (DAS28(CRP)) and time-averaged DAS28(CRP) over 4, 8 and 12 weeks were the strongest predictors of insufficient response to methotrexate and CRRP. Addition of adalimumab to methotrexate therapy was associated with better clinical, functional and radiographic outcomes after 1 year compared with continuing on methotrexate monotherapy. Conclusions In patients with early RA, baseline disease characteristics and early disease activity can predict response to methotrexate treatment and radiographic progression at 6 months. The addition of adalimumab at 6 months after methotrexate failure is associated with improved outcomes. These results support treatment-to-target strategies and timely adaptation of therapy in patients with early RA. Trial registration number NCT00420927, NCT00195663; Post-results.


We present a finite-element analysis of the coupled electro-thermal behavior of a mm2-sized power DMOS device, with a focus on resolving μm-sized structures. For a reliable power technology, the predictions of current and temperature distributions under self-heating are vital for reaching long device lifetime. Two aspects of our approach are unique: First, we have integrated the active region of the DMOS into the finite-element program code as a nonlinear voltage and temperature dependent tripole, incorporating local biasing and temperature conditions. Second, to model small features like defects or process-induced imperfections in sufficient detail, we use the Nitsche-type nonmatching grid technique to include the substantially finer meshed microscale geometry. This allows us to study very local changes in temperature and biasing conditions, which are normally not accessible. The methodology is applied to a state-of-the-art power technology device with integrated current sensor to validate the methodology. Good agreement is found between results and experiments.


This study aims to determine Work conflicts, Job Stress and Job Satisfaction on Employee Performance of PT. Federal International Finance Group (Fif-Group) Sidoarjo.This research is a type of quantitative research with hypothesis testing. The sample used in this study were 30 employees at PT. Federal International Finance Group (Fif-Group) Sidoarjo. The analysis tools used in this study are multiple linear regression analysis, multiple correlation coefficient (R), and classical assumption test using SPSS version 18 for windows. Primary data in this study were obtained from questionnaires which were measured using a Likert scale which was tested for validity and reliability. The results of this study prove that work conflict affects employee performance, job stress affects employee performance and job satisfaction also affects employee performance. job satisfaction variable that most influences employee performance.


Recently, while redefining the concept of globalization, literature research is also de-constructing the dichotomous logic of central and marginal literature. This research provides a basis for marginalized texts to be reinterpreted as communal texts in local literature. The core of this research is to examine how the problem of space and acceptance in local literature is relocated as a new subject in a specific historical space. For this purpose, this research examines the de-mythification and Celticism of myths and spaces created in the space of Ireland as a local literature in the poetry of Seamus Heaney.


Five semidiagrammatic drawings illustrating findings in case RC 6. Degenerating fibers of passage indicated by heavy dots, terminal degeneration by finer stippling


Subtitle: With prices of raw materials rising all the time, tyre manufacturers must decide whether of not to pass the costs onto their customers. However, there are a number of factors that can prolong the lifespan of tyres and reduce overall costs for operators.


This paper reports the molecular design and click syntheses of novel shape amphiphiles with molecular architectures beyond conventional giant surfactants. They include (1) the giant bolaform surfactant which consists of a polystyrene (PS) chain tethered with one hydrophilic POSS cage at each end of the chain (DPOSS–PS–DPOSS); (2) the giant gemini surfactant which contains two hydrophilic POSS cages and two PS tails tethered at one junction point (2DPOSS–2PS); and (3) the multi-headed giant surfactant which is composed of three hydrophilic POSS cages tethered at one end of a PS chain (3DPOSS–PS). The syntheses were achieved in a modular and efficient fashion following the sequential click approach in good yields, providing easy access to a family of shape amphiphiles with precise chemical structures and fine-tuned interactions for a systematic study of structure–property relationships.


This paper proposed a new combined evaluation model. Firstly, it chose some different single evaluation methods to evaluate the objects from different angles; secondly, it built up an evaluation model from the angle of individual object. This model is on the base of related decision-maker's preference, it takes the evaluation results of single evaluation methods as inputs, and the optimal evaluation value of corresponding individual object as target; finally, it proposed a crossover evaluation model to carry out the combined evaluation. The model proposed in this paper takes into account the decision-maker's preference and the objects willingness simultaneously; it is an effective combined evaluation model.


Two works,The Closing of the American Mind by American professor Allan Bloom and Doctrines of University and the Loss of Modern University Education by Chinese professor Zhang Rulun,both analyze the current situation of university education in their respective countries from different perspectives.After reading these two works,the writer of this article holds the view that in order to solve the problems with China' s university education,we should firstly give special emphasis on the human-centeredness of education and attach adequate importance to philosophy—the learning of wisdom.Secondly,we should stress general education.And thirdly we should emphasize cultural construction.


Two-particle colloids containing nanomagnets and microscale mirrors can be prepared from iron oxide nanoparticles, microscale metal flakes and high-density liquids stabilizing the mirror suspension against sedimentation by matching the constituent's density. The free Brownian rotation of the micromirrors can be magnetically controlled through an anisotropic change in impulse transport arising from impacts of the magnetic nanoparticles onto the anisotropic flakes. The resulting rapid mirror orientation allows large changes in light transmission and switchable optical reflectivity. The preparation of a passive display was conceptually demonstrated through colloid confinement in a planar cavity over an array of individually addressable solenoids and resulted in 4 × 4 digit displays with a reaction time of less than 100 ms.


The standard treatment for non‒small cell lung cancer (NSCLC) includes lobectomy, pneumonectomy, and sublobar resection. In selecting the surgical method, doctors need a safer, less invasive method that can be done more rapidly and provide the most suitable type of resection at different stages of NSCLC. Sublobar resection (including segmental resection and wedge resection) can treat smaller lesions and offers better recovery of postoperative pulmonary function. In earlystage lung cancer in patients who are physically fit and have good lung function, there seems to be no difference in perioperative mortality and morbidity rates for lobar or sublobar resection (1). Therefore, sublobar resection is often selected as the surgical method for early-stage lung cancer. Lymph node dissection, especially more extensive regional dissection, is thought to improve survival rates in patients with early-stage lung cancer (2). It is often necessary to combine lymph node dissection with sublobar resection in patients with early-stage lung cancer to estimate the progress of the tumor and the stage of cancer. Researchers on the topic "strategies of lymph node dissection during sublobar research for early-stage lung cancer" highlight the need for preoperative evaluation and intraoperative lymph node dissection in patients with early-stage lung cancer. They also provide a snapshot of the status of the research and the ongoing research on sublobar resection. The preoperative evaluation of benign and malignant pulmonary nodules in early-stage cancer plays a significant role in the selection of surgical method and prognosis of patients. Common evaluation methods include imaging, gene detection, and tumor-related marker detection. Ye et al. (3) conducted a prospective study of 125 preoperative patients with NSCLC with nodules of 1 cm or less. Their analysis showed that patients with pulmonary nodules of 10 mm or less detected by circulating genetically abnormal cells (CACs) before operation could effectively diagnose lung cancer and help doctors choose the appropriate treatment. Imaging is indispensable in the preoperative evaluation of pulmonary nodules, but it is not sufficient for the total analysis. Therefore, Wei et al. (4) combined CEA, CYFRA21-1, and NSE tumor markers with imaging to evaluate benign and malignant pulmonary nodules. They found that the sensitivity of tumor markers combined with imaging in classifying lung cancers was significantly better, at 90%, than other diagnostic methods. The NSE marker combined with imaging was more advantageous in the diagnosis of small cell lung cancer. In addition, multivariable logistic regression models with backward selection based on the Akaike information criterion were used to identify independent predictors. Xia et al. (5) retrospectively studied 763 patients with pulmonary nodules who underwent lobectomy or sublobar resection. They


Using literature method,the author analyzes the creation of ancient PE in China and Greece,and finds that there are a lot of similar cases which caused the prosperity and the decline of the their ancient PE.The author expounds the reasons in history and politics.


At the dawn of the XXI century, traditional models are no longer able to give satisfactory answers to the society demands, precipitating a new reinvention of the State. This corresponds, on the one hand, to the emergence of modern Information and Communication Technologies (ICT), ubiquitous and interactive. On the other hand, this phase is marked by the increasing fragmentation of State power in parallel with the proportional increase of democratic regimes around the world. In this context emerges the "Responsive Governance", a model driven by principles of accountability, transparency and participation, where effectiveness is linked to its key attribute: responsiveness. This article aims to analyze the relations between electronic participation and three key aspects: e-government, government effectiveness and accountability. To do so, it employed a deductive and objective approach which derived a working strategy of quantitative nature using a bivariate analysis method called the Pearson correlation. In short, it was found that high rates of development of government are correlated with high levels of electronic participation. Furthermore, it was found that the higher the level of electronic participation the higher the level of government effectiveness and also accountability.


Indirect ELISA has been widely applied in the detection of classical swine fever antibody levels,rapid diagnosis and epidemiological investigation,for its sensitive,specific,simple,fast,stable advantages,high throughput and easy operation etc.,it showed good application prospect.Studies on indirect ELISA method and its application in classical swine fever diagnosis were reviewed briefly in order to provide references for comprehensive prevention and control of classical swine fever in China.


Abstract : Seismic noise refers to the ambient ground motion within which signals of interest are to be detected. Four categories of seismic noise identified by source-road (vehicle), train, wind, and ocean micro-seisms-are reviewed. Examples are given of the variation in seismic noise by geographic location and by season and time of day, and of a technique to characterize seismic site effects from local seismic noise. Noise impact on seismic detection of personnel is discussed, and ground motion induced by a walking person is compared with noise at a rural site when cultural activity is minimal and when a moving vehicle is present.


Azathioprine is an immunomodulator commonly used in renal transplant recipients and to treat lupus erythematous, and inflammatory bowel disease, and as second-line therapy in cases of rheumatoid arthritis. Here, we present a case of non-segmental vitiligo treated with low-dose azathioprine developing life-threatening pancytopenia with febrile neutropenia and trephine biopsy-proven drug-induced myelosuppression. The patient needed broad-spectrum antibiotics and granulocyte colony-stimulating factor (G-CSF) support with intermittent transfusion of blood products to completely recover from myelosuppression. It took almost a month for the patient to completely recover from the cytotoxicity caused by azathioprine. Interestingly, the patient had normal thiopurine methyl transferase (TPMT) activity and wild-type TPMT allele. We tried to outline how these types of patients can be managed and to emphasize the need for continuous monitoring of blood counts in patients receiving azathioprine to prevent life-threatening cytopenia even with normal TPMT activity and wild-type TPMT allele.


Over the past 10 years, ATTR amyloidosis has been the target of six placebo-controlled randomized clinical trials for novel drug development. In addition to establishing the beneficial effects of t...


are "flitting blade[s] in / the dark" that cut away at romantic idealism to reveal Native lives as tender as they are grim (19). Resisting overt moralizing, this collection is like the tincture in the opening poem "Root Juice"; it contains an "ancient thing in plastic" that provides "the means to heal," but there is "no hymn or myth [that] tells how this root grows" or how the healing takes place (3). Some readers might find Frazier's medicine distasteful as his subjects involve sexual exploitation, domestic violence, drunks, huffers, and rough neighborhoods. However, others will gladly "[tighten their] mouth[s] for a drink" and find in Dark Thirty a vigorous contribution to contemporary Native American poetry (3).


For effective integrity management of marine renewable energy systems in the dynamic and uncertain ocean environments, understanding the failure dynamics is crucial. The cost of investment in marine/offshore renewable energy infrastructures and the associated cost due to failure and loss of energy production necessitate a predictive monitoring methodology that is dynamic and adaptive. This paper presents an integrated multi‐state pure‐birth‐pure‐death Markovian‐net profit value model for the offshore turbine subsystem failure analysis and its cost‐based consequences. The integrated model captures the offshore turbine subsystem's dynamic failure states and its economic implications due to the cost of energy loss and downtime for the period under consideration. The model applies a phase‐type exponential distribution to describe the monotonic state of failure. The methodology is demonstrated with an offshore wind turbine gearbox, and it captures the dynamic state of the system and its failure mechanisms. The cumulative effect of the subelements deterioration decreases the gearbox performance by over 35% within the first 2 years of operation.


New South Wales Court of Appeal, Rolfe J, 16 February 2006. Injury suffered while attending a function at the property of Guides and dispute as to level of care required.


Objective To observe the effects of high mobility protein A2 (HMGA2) overexpression on proliferation and cell cycle of rat pituitary tumor cells.Methods The mRNA and protein expression of HMGA2 in rat GH3 cells transduced by pIRES2-dsRed-HMGA2cDNA were examined by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting.The effects of the HMGA2 overexpression on GH3 cell proliferation and cell cycle were analyzed by cell counting kit-8 (CCK-8) assay and flow cytometry.Results pIRES2-dsRed-HMGA2cDNA transfected rat GH3 cells after 24 h the HMGA2 mRNA and protein expression levels were respectively higher than the control group 26.40% and 36.60%,the difference was statistically significant (P < 0.05).To compare with control group the number of pIRES2-dsRed-HMGA2cDNA group cells increased at 24,48,72,96 h (P < 0.05).Flow cytometry analysis showed that the experimental group,the percentage of cells in G0/G1 phase was significantly reduced compared with the control group,(43.15 ±0.63)% vs.(65.33 ±0.37)%,while the S phase was significantly increased compared with the control group (39.57 ± 0.65) % vs.(18.26 ± 0.54) % (P < 0.05).Conclusion HMGA2 overexpression increases rat GH3 cell proliferation and changes normal cell cycle.

Key words:
High mobility protein A2;  Over expression;  Pituitary tumor;  Proliferation;  Cell cycle


The optical conductivity of single crystals of Na_xCoO_2 for $x$ = 0.57 is first reported between 295 and 30 K. In the far infrared, an "anomalous Drude" analysis leads to a carrier effective mass of 5 electron masses. That this high value is due to strong electron-phonon coupling is suggested by the Fano distortion of a phonon at 570 cm^-1. A peak at 8800 cm^-1 scales with the charge transfer band of several high-$T_c$ cuprates by simply replacing the in-plane Cu-O bond length with that for Co-O.


Legal Business Contracts govern the business relationshipbetween trading business partners. Business contracts are likeblueprints of expected business behaviour from all thecontracting parties invo ...


Early recognition and prediction of human activities are of great importance in video surveillance, e.g., by recognizing a criminal activity at its beginning stage, it is possible to avoid unfortunate outcomes. We address early activity recognition by developing a Spatial-Temporal Implicit Shape Model (STISM), which characterizes the space-time structure of the sparse local features extracted from a video. The early recognition of human activities is accomplished by pattern matching through STISM. To enable efficient and robust matching, we propose a new random forest structure, called multi-class balanced random forest, which makes a good trade-off between the balance of the trees and the discriminative abilities. The prediction is done simultaneously for multiple classes, which saves both the memory and computational cost. The experiments show that our algorithm significantly outperforms the state of the arts for the human activity prediction problem.


We reexamine and critique the classical area control error concept used in automatic generation control, and propose a new error signal termed the area injection error. Unlike the ACE, the AIE uses direct measurement of generator power levels, yielding improved AGC performance in the presence of bias uncertainty and nonlinearity in generator turbine-governor responses. As a by-product of our analysis, we conclude that the effective frequency biasing found in a common textbook implementation of AGC is larger than intended, resulting in unintended interaction between control areas. Our theory is validated via simulations on a detailed two-area test system.


ObjectiveVenous thrombosis and pulmonary embolisms are major complications associated with acute spinal cord injury. The purpose of this study was to perform a cost analysis on the two pharmacoprophylaxis regimens suggested for deep vein thrombosis prophylaxis in this population. MethodsEfficacy and safety data were obtained from the literature. ResultsResults of the cost analysis demonstrates that adjusted dose unfractionated heparin produces a cost savings over enoxaparin at 30 mg every 12 hr. ConclusionFurther studies are needed to determine the most cost-effective therapy for preventing deep vein thrombi in this population.


Esteeming and appointing the person with virtue and ability is the kernel of Xun zi's view on talents .Its main contents include five parts, namely , the importance of talents, the criterion of talents, the selection of talents, the utilization and the test of talents. The author comments on them, and analyzes its contemporary significance.


A high performance peak sample and hold circuit is key to a high speed,high precision acquisi- tion system for nuclear pulse.On the basis of semi-Gaussian waveform,the relation between the aperture time of the peak sample hold circuit and the shaping time constant of nuclear pulse and the relation be- tween the conversion time of ADC and the count rate of nuclear pulse were derived theoretically.Accord- ing to these relations,the performances of several peak sample hold circuits were analyzed,and some design principles of these circuits were also gave.Finally,the design of the peak holder for a measure- ment instrument of liquid level of Coke-cracking Tower based on dual-energy gamma-ray transmission by use of PKD01 IC is introduced.


e20568Background: Brain metastases (BM) are common and affects near half of patients with non-small-cell lung cancer (NSCLC), with poor prognosis. Few data is available about this group of patients...


It's the journalist's obligation to avoid both the cerebral peaks and rarified air of the literary commu nity and the substandard committee writing of who-what-when-where news, to apply "direct perceptions" and "immediate intuitions" to events, and to express those verdicts regularly in clear and cogent prose. It's the editor's obligation to have faith in that prose.


ABSTRACT Aim: Breast cancer still continues to be a leading cause of cancer-related death among women worldwide. Consequently, the development of a new effective therapeutic strategies for breast cancer is urgently required. Previously, we have shown that Hedgehog (Hh) signaling is activated in CD24-CD44+ breast cancer cells which are candidates of cancer stem-like cells and it may play an important role in these cells. However, the precise mechanim of Hh signaling activation in CD24-CD44+ breast cancer cells is still unclear. In this study, we focused on the CD24 molecule and investigated the mechanism of Hh signaling activation in CD24-negative breast cancer cells. Methods: Breast cancer cell lines, MCF-7 and HCC-1937 were used in this study. CD24 and Hh ligand; sonic Hh (Shh) were inhibited using small interfering RNA (siRNA). Expressions of CD24 and Hh signaling-related molecules were assessed by real time RT-PCR, flow cytometry and fluorescent immunochemistry. Invasiveness and colony formation were estimated by matrigel invasion assay and soft agar colony formation assay, respectively. Five-week-old NOD/SCID mice were used in xenograft experiment. Gli1 expression was used as an index of Hh signaling activation. Results: 1) CD24 siRNA transfected cells significantly increased invasiveness and colony formation compared with controls. 2) CD24 siRNA transfected cells significantly increased Hh signaling componens; Shh and Gli1 expresions compared with controls. 3) Invaded cells in matrigel invasion assay showed lower CD24 expression and higher Shh expression than non-invaded cells. 4) Shh siRNA and CD24 siRNA concurrent transfected cells significantly decreased Gli1 expression, invasiveness and colony formation compared to CD24 siRNA transfected cells in vitro. 5) Tumor volume and tumorigenesis in Shh siRNA and CD24 siRNA concurrent transfected cells was significantly lower than those in CD24 siRNA transfected cells in the xenograft mice model. 6) In fluorescent immunohistochemical staining using surgically resected specimens from cancer patients, Shh expression was negatively correlated with CD24 expression. Conclusions: Our results suggest that CD24 negative breast cancer cells may induce proliferation and invasiveness through upregulation of Shh. Therefore, Hh signaling may be a suitable therapeutic target in CD24-negative breast cancer. Disclosure: All authors have declared no conflicts of interest.


In future more stringent emission limits for nitrogen oxides (NO x ) should apply to waste incineration plants. With the amendment of the 17. Federal Immission Control Ordinance (17. BImSchV) a limit of 100 mg/m 3 VN for NO x as annual average value will be introduced. This applies to all plants, which go into operation from 1 January 2013 or will be changed significant and with a rated thermal input greater than 50 MW By using nitrogen reduction methods according to the SCR- or SNCR-principle the NO x emissions are significantly below the existing limit value for the daily average of 200 mg/m 3 VN [1]. With regard to the intensification of the NO x limits operational tests were carried out at the waste incineration plants Rugenberger Damm (MVR) and Borsigstrasse (MVB) in Hamburg, which both use the SNCR technique. Based on these tests the effects of different settings on the amount of NO x emissions, injected ammonia water and ammonia slip were analysed. Basically, it is possible to observe the NO x limit of 100 mg/m 3 VN as annual average value without disproportional increase of ammonia slip. The requirements are a reliable and fast measurement data recording as well as an injection of ammonia water in the optimal temperature range.


This text has analyzed the design ideas of Philips as the world-class trans-corporation. Through the study on strategy of Philip enterprise, it puts forward the concept of design management and realizes the combination of design with management in enterprises. Finally, it will make a contribution to promote enterprise's benefit and environmental culture.


According to the mineralogical analysis of copper slag and the oxidation mechanism of fayalite,the experimental method of oxidation modification of copper slag at middle-low temperature was suggested.The impact factors on mineralogical changes of copper slag like oxygen flow,oxidation temperature and oxidation time,etc.were investigated.The results showed that as the increasing of oxidation temperature and oxidation time,the fayalite transformed into Fe_3O_4 and a small amount of Fe203 gradually,and the mineral particle size tended to be uniform.The optimal oxidation result was obtained for copper slag with particle size of 35~50μm under the conditions of oxidation temperature of 800℃,oxidation flow of 0.1L/min and oxidation time of 60min, the area fraction of Fe_3O_4 reached 43.39%.The study lays a foundation for the further improvement of magnetic separation effect and increase of recovery of iron resources in copper slag.


This paper presents the material characterization of boron- and phosphorus-doped LPCVD polysilicon films for the application of thermoelectric power generators. Electrical resistivity, Seebeck coefficient and thermal conductivity of polysilicon films doped with doses from 4 × 1015 to 10 × 1015 at cm−2 have been measured at room temperature. Specific contact resistance between polysilicon and aluminum is studied and nickel silicidation is formed to reduce the contact resistance. The overall thermoelectric properties, as characterized by the figure of merit, are reported for polysilicon doped with different doping concentrations. For the most heavily doping dose of 10 × 1015 at cm−2, figure of merit for p- and n-type polysilicon is found as 0.012 and 0.014, respectively. Based on the characterization results, a CMOS compatible thermoelectric power generator composed of boron- and phosphorus-doped polysilicon thermopiles is fabricated. When 5 K temperature difference is maintained across two sides of a device of size of 1 cm2, the output power is 1.3 µW under a matched electrical resistance load.


This paper contains brief information about symbolic computation techniques. The location of symbolic computation within Computer Language classification is defined. MATLAB + MuPAD as combined method have been introduced. After some introductory information about MuPAD, some important applications of MATLAB + MuPAD are given. The method, transfer from MuPAD into MATLAB has been discussed as well. These two methods have been illustrated to engineering students on selected topics.


This research has a purpose of comparing the implementation of scientific learning management with the implementation of speech variation learning management and its impact towards students inside to class learning process on the Hindu religious education study program Institut Agama Hindu Negeri Tampung Penyang Palangka Raya. The approach used in this research is qualitative with the descriptive design. Research is conducted in Hindu religious education study program Institut Agama Hindu Negeri Tampung Penyang Palangka Raya Indonesia. The researcher collected a huge range of information on two variables by interview and observation with 12 university students and 8 lecturers. Data analysis of interview results used interactive analysis model from Miles and Huberman while data analysis of observation used checklist method. On planning, implementation and supervision process of scientific learning, several findings were found, such as the more active students' role during the study process, and lecturer becomes a facilitator and guides the students who faced difficulty in their study and follow up on students' development evaluation results. Scientific learning in higher educational institutions in Indonesia has only been effective since 2017. Therefore, this research is hopefully able to provide knowledge particularly on the effect of scientific learning on students' active role during the study process.


The pre-launch functioning data of the Field Joint Protection System (JPS) used on QM-8 are presented. Also included is the post fire condition of the JPS components following the test firing of the motor. The JPS components are: field joint heaters; field joint sensors; field joint moisture seal; moisture seal kevlar retaining straps; field joint external extruded cork insulation; vent valve; power cables; and igniter heater.


Purpose

The purpose of this paper is to provide a commentary from a Scottish perspective on some of the issues raised in the paper "Variation in rates of inpatient admission and lengths of stay experienced by adults with learning disabilities in England".

Design/methodology/approach

The policy context in relation to people with learning disabilities in Scotland is reviewed, alongside an update about a current Scottish Government project focussed on understanding and addressing the issue of people with learning disabilities whose discharge from hospital is delayed.

Findings

As regards to people with learning disabilities who are inpatients in hospitals in Scotland, there are similar themes in common with those in the paper by Elaine James and colleagues; however Scottish policy has developed differently from that in England in this area.

Originality/value

This commentary adds to the discussion by contributing a Scottish perspective on issues and outlines work being done to address the need for people with learning disabilities and complex needs in Scotland to live within their local communities.


On a city scale, public spaces are often an effective place for urban people to carry out various activities and social interactions. In this space, people can carry out their various needs, both physical needs such as sports, gathering, work, and spiritual needs such as relaxation, getting out from everyday boredom, and so on. This study aims to determine how the grouping of activities that occur in a public space based on time, intensity of visits, and the age of visitors. This research applied an exploratory qualitative grounded theory approach. After the data was collected through an online questionnaire, the data was processed in three stages, namely open coding, axial coding, and selective coding. The results of the study revealed that there are four large groups of activities that are usually carried out in public spaces based on time, intensity, and age. The four groups are groups of health, hobby, relaxation, and lust activities.


This paper introduces the requirements of toxicological test on the hazardous chemicals in the REACH.The toxicity of sixteen hazardous chemicals in textile industry,such as carcinogenic dye,allergenic dye,chloro-organic carriers etc.,is analyzed.The functions and testing methods concerning carcinogenicity,teratogenicity,mutagenicity and allergenicity are described.


The present work aims to answer the question about what is the influence of the knowledge of statistics in the learning about Occupations and Salaries for students of a Higher Course of Technology in Human Resources Management in a Private Education Institution of the city of Sao Paulo? In order to answer this question, the following general objective was established: to analyze basic statistical knowledge used in the classroom in the study on salary research and, specifically, to understand the learning styles of the students, proposing actions aligned to the profile of these students. In terms of methodology, this article has a qualitative approach, in an exploratory-descriptive order, since it aims to obtain definitions, descriptions, expositions and information about a circumstance, identifying the present relations between the factors that compose it and the subjects involved. In spite of the qualitative nature, the ILS (Index of Learning Styles) questionnaire, by Felder and Soloman (1991), was also used to classify the learning styles of the subjects involved in the work and to determine the learning styles of the subjects. two classes worked.


Demands towards the increase of high profits and the safety of the agricultural product have made the use of pesticide unavoidable. Regulation and government effort to prevent farmers from the dangerous use of pesticide has long been implemented but the fact is that until nowadays the use of the pesticide by farmers is far from safety standard. Both the effect of acute and chronic pesticide intoxication can create nervous system disorder and even death. Most users do not have enough knowledge about the danger of the pesticide and safety work procedure. In order to increase the quality of the farmers' health and to prevent them from the effect of acute intoxication and long term use of pesticide effect, it is necessary to develop strategies to anticipate the effect of pesticide through Total Ergonomic Approach. This approach (TEA) includes SHIP approaches (Systemic, Holistic, Interdisciplinary and Participatory) and Appropriate Technology assessment in design. Based on the anticipating strategies towards the effect of pesticide intoxication on the farmers it is hoped that in the future the use of pesticide can fulfill safety standard and increase the life quality of farmers and community in general.


The presenting paper investigates on the validation of the turbulence intensity (TI) modeled by a CFD tool. Six meteorological masts, equipped with cup anemometers, have been used for the purpose. Three different turbulence closure schemes, which are the SST k-omega and the k-epsilon in two different configurations, have been tested. The flow analysis shows a qualitative agreement between measurements and models, which are capable to simulate the turning of the wind towards South when it comes from SSE. Furthermore, the simulations predict a zone of high turbulence in the northern part of the site that is confirmed by the local measurements. The scores for TI have been quantified by considering the observed directional frequencies in the validation analysis. For the testing site, the SST k-omega scheme achieves the best performance when using the TI definition which is representative of the longitudinal fluctuations of the velocity vector, against the other one, which considers the fluctuation of the horizontal vector. Lastly, the model errors have been used to correct the simulated values using two approaches; the analysis shows that, for the presented case, these correction methods do not always improve the accuracy of the simulations.


"Inheritance" will stand here for "nonmonotonic or defeasible inheritance". We will use indiscriminately "inheritance system", "inheritance diagram", "inheritance network", "inheritance net". In this introduction, we first give the connection to reactive diagrams, then give the motivation, then describe in very brief terms some problems of inheritance diagrams, and mention the basic ideas of our analysis.


An improved method of the string and a plurality of candidate strings matching the query is a less computationally intensive lower bound estimate instead of calculating the string edit distance is computationally intensive. Lower bound of the string edit distance between two strings is estimated to make the two equal to a length shorter by adding padding character string calculated. Then the string elements are ordered, and the sum of the substitution costs of corresponding elements.


Agriculture provides the main income for the economy in Mediterranean countries. Morocco, a North African and Mediterranean country, surrounded by the Mediterranean Sea and Atlantic Ocean, is characterized by a hot and humid climate which could probably lead to mold contamination and mycotoxin production especially in coastal areas. This contribution gives an overview of the contamination by fungal mycoflora of cereals and coffee consumed in the North of Morocco .Some species belonging to the genus Aspergillus that are known to be a potential producers of ochratoxin A(OTA), this mycotoxin has been shown to be a nephrotoxic, hepatotoxic, teratogenic and possibly carcinogenic for humans. The aim of the present work was to know the fungal distribution in some crops collected in northern Morocco, Tangier city. The species of saprophytic fungal were identified including Aspergillus and Penicillium that contaminate wheat, rice and coffee beans. Studies on fungal DNA detection in 88 fungal samples have been performed. They were identified at the species level, by sequencing the internal transcribed spacer (ITS4, ITS5) of ribosomal DNA (rDNA). This is the first report on the contamination by mycotoxigenic fungi in coffee from Morocco, and also there is no previous work exists on contamination by these fungi in cereals samples from North of Morocco.


High‐protein distillers dried grains (HPDDG) is a co‐product of ethanol production that uses prefractionation technology. A 70‐day growth trial was conducted to investigate the effect of partial replacement of dietary soybean meal by high‐protein distiller's dried grains (HPDDG) with protease enzyme supplementation (PROXYM ULTRA®) on growth performance, physiological parameters and histological changes of the intestine of European sea bass, Dicentrarchus labrax fingerlings. The results indicated that increased dietary HPDDG levels up to 50% of HPDDG supplemented with protease significantly increases growth performance and feed utilization and improved FCR of sea bass. In addition, replacement of SBM by HPDDG supplemented with protease enhanced feed intake efficiency and the health status of fish. Haematology and serum biochemistry (haemoglobin (Hb)), red blood cells (RBCs), white blood cells (WBCs) and humeral immune parameters including total protein, globulin, cholesterol, lysozyme activity and total antioxidant capacity significantly increased with increase in HPDDG supplemented with protease in the diets. Results of this study indicated that HPDDG supplemented with protease is a good alternative protein source for aquaculture feed and can be included up to 50% as a replacement of SBM without compromising growth performance and physiological parameters of sea bass.


The Universities UK Taskforce published its report on tackling violence against women, hate crime and harassment in UK universities in 2016 (UUK, 2016). The UUK report identified seven key components for change (UUK, 2016: p59):

1. A commitment from senior leadership;
2. Ensuring an institution-wide approach;
3. Prevention of incidents;
4. Enabling an effective response;
5. Managing situations where students have committed an offence;
6. Sharing of good practice;
7. Assessment of support needed with regards to online harassment.

Many universities in England and Wales received HEFCE funding to tackle the violence against women (VAWG) work stream forward.
Our study investigates the future sustainability of such initiatives.


A number of Thirsk businesses and organisations are supporting Thirsk School's Under-16 Boys Hockey Team as they celebrate reaching the finals of the ...


This paper will survey recent advances in research aimed at developing new image and information guided procedures in orthopedic surgery. These procedures are based on new methodological studies oriented towards the modelling of bone structure, which allow the physician to better understand the relationship between form and functionality of movements in the osteo-articular system and to improve diagnosis, therapeutic action and follow-up of the patients.


The purpose of study is on revealing the meaning and significance of 'The Poetic' in modern architecture and viewing the structure constructed. According to the study, we establish the concept 'The Poetic' based on poetic works of Heidegger and analyze several foundation of buildings which are appreciated as poetic. The following is our conclusions of the study. In modern architecture, 'The Poetic' refers to the architecture as planned Indeterminacy, while the buildings are on tension between determinacy and Indeterminacy. Thus, the study has significance to conclude planned meaning of the poetic buildings by analyzing the poetic in architecture planning out of previous sentimental viewpoint.


Purpose. This study aims to assess the regional market concentration of multimodal transport (on the example of the Zaporizhzhia region) and the distribution of "market power" in the freight transport segment between market participants in multimodal transportation. Design/methodology/approach. Authors in the article used the literature review method to substantiate the importance of identifying competition and distinguishing it among other related concepts in the development of regional markets for multimodal transportation by disclosing the specifics of their geographical location, availability of water resources, the establishment of logistics infrastructure, the volume of export-import flows of goods and other essential features in the process of an integrated approach to the formation of the regional market for multimodal transportation and, thus, to justify the relevance of the research topic. The market concentration of multimodal transport in the Zaporizhia region (using: concentration index, Lind index, Herfindahl–Hirschman index, and Gini index) allowed us to identify the company that forms the "core" of the market and determines its role in shaping the market. (According to analytical calculations, this includes PJSC "Ukrzaliznytsia"). The conducted analytical analyses allowed to suggest directions of development for the regional multimodal transportations market, particularly the identification of competition levels. Findings. Were proved the hypothesis concerning the need to eliminate the market monopolization of multimodal transportation in the Zaporizhzhia region and strengthen intra-industry and intersectoral competition in it. In particular, the development of the regional market of multimodal transportation should meet the industry needs and take into account the sectoral and regional peculiarities of all transport modes' functioning to develop multimodal technologies of cargo transportation. Practical implications. This study's results are of interest to multimodal transport market operators and cargo owners who are interested in the active implementation of logistics concept into regions development, the practical implementation of which should be, in particular, the intensification centers of cargo handling. These centers are entrusted with the functions of transshipment of goods from one to other transport modes, the allocation of links in the integrated transport chain, the formation of economic development centers in certain regions. This involves, in particular, the construction of multimodal regional clusters. In this way, it is expected to increase the involvement of cargo flows in the regions, the development (intra-industry – between different participants in the transportation process of goods; intersectoral – between different modes of transport in the area; commodity competition – under the conditions of transition to cargo substitute transportation; geographical – in terms of goods delivery by an alternative route); growth of employment in the freight sector and other related industries, etc. The evaluation results of the development of multimodal cargo transportation can be taken into account by the Coordination Council for Logistics at the Ministry of Infrastructure of Ukraine to form strategic foundations for the country's logistics system development. The components of such a strategy should relate to the improvement of multimodal freight transport, the optimization of regional and interregional transport cooperation, the progress of the management of logistics supply chains; increasing the profitability of the transport sector, the formation of economic benefits from the trade development, the national economy cooperation, and development. Originality/value. Assessing the concentration of regional markets will provide an analytical basis in the process of forming a mechanism to ensure the efficiency of multimodal freight comprehensively and minimize interregional asymmetries: the levels of cargo flow by the stated needs of consumers; state of transport and logistics infrastructure; provision of all types of transportation method, service levels, etc.