To quantitatively analyze and choose regional leading industries,12 quantitative analysis in-dexes were chosen: location quotient,employment location quotient,sensitivity coefficient,impact coeffi-cient,income elasticity of demand,speed of technological progress,utilization rate of funds,all staff productivity,consumption rates of energy output value,management coefficient of three wastes,staff av-erage incomes in different industries,income growth rate of staff in work.Factor analyses of Liaoning's leading industries were made by means of SPSS.Five major factors and factor score functions of Liaon-ing leading industries were figured out.Based on factor score functions and variance contribution rate of each factor,comprehensive scores of 39 industries were calculated.Eight of them were selected as Liaoning's leading industries based on qualitative analysis.The results offer guidance for the choice of leading industries in Liaoning.


The implementation of Quality Management Systems plays a major role within the majority of the companies wishing to excel in their business operations and customer service. Eskom embarked on a journey to Business excellence in March 2012, which involves the implementation of auditable Quality Management Systems in all its divisions and departments in its value chain . The company achieved a companywide ISO 9001 :2008 certificate in March 2013, compliance and consequent certification are a major achievement, particularly for a company of Eskom's size, more so due to the short period of time in which this achievement was reached. For any company to reap the benefits of ISO 9001 :2008 Quality Management System certification ; surveillance audits, internal audits and other risk mitigation initiatives has to be conducted by the company as part the continuous improvement initiatives prescribed by the ISO 9001 standard. This study was carried out by obtaining data from audit and inspection reports, focused group discussions with professional quality practitioners and a site visit to different power generating stations was also conducted by the researcher, engaging with different people at shop floor level as part of the direct observation data collection. Although control of product and service non-conformances goes a long way in reducing failure rate in company operations, OMS also plays a critical role in ensuring that operations are controlled and ran efficiently. Results obtained from this study indicated that Eskom has not fully benefited from the implementation of the ISO 9001 :2008 systems as a result of inconclusive audit findings, reoccurring non-conformances relating to the Turbine and Boiler equipment And key terms ISO 9001 :2008, Quality Management System, Quality Management Representative, Management Systems, Process management, Business improvement methodologies, Document management, Business excellence, Continual improvement, Total quality management system, Cost of quality, Six sigma, Lean manufacturing


The gut microbiome develops in prenatal life and progresses through infancy and childhood. Identified factors that impact the quantity, quality, and diversity of the early gut microbiome include mode of delivery, early diet, environmental exposures, disease conditions, and treatment. Optimal gut health in childhood is impacted by microbiome stability and diversity. This narrative review provides an overview of the important factors including genetic, epigenetic, nutritional, and environmental exposures, playing a foundational role in establishing the early gut microbiome during the critical first "1000 days" of human life and its impact on pediatric obesity, allergy, and gastrointestinal disease.


Nowadays, the separatists of Taiwan advocacy that Taiwan is a "oceanic nation" which has no relation to China. This advocation of oceanic culture represent an evident political attempt to separate from China.on the contrary, The current Taiwanese literature has proved that Taiwanese oceanic culture is all the same a representation of the Chinese multi-subject .For example, the oceanic poem of Wang Qijiang, the people which have fused oceanic character and continental character in Lu Zhezi's narrative works, the historical and national meditation of Dong Nian, Xiaman·Lianboan and Liao Hongji's creature of ocean ,all of those are provided with the key Chinese traditional value of culture .


stitutes optimal—or at least good—product market and financial market institutions. There is much less agreement on what constitutes optimal—or at least good—labor market institutions. As a result, the public debate is too often dominated by clichés and slogans. "Get rid of labor market rigidities" is one of the most frequent. Meanwhile, policymakers focus on politically feasible, incremental reforms, with little sense of the ultimate goal. Economists could play a more useful role here. This is why Jean Tirole and I decided to explore the optimal design of labor market institutions. This paper represents a progress report.1 It gives a sense of the general architecture we see coming out of our analysis. It is probably best to start with three warnings. First, our research so far has focused on unemployment insurance and employment protection, which we see as the two pillars of labor market institutions. Many other dimensions are relevant, including minimum wages, negative income taxes, labor laws, and collective bargaining. We have not analyzed these issues in detail, so I only touch on them here. Second, one size does not fit all. The economic principles we derive are quite general, but the specifics are likely to differ across countries, according to income level and institutional development. What may be optimal for Sweden may not be optimal for Chile, for example. Finally, having a sense of the ultimate goal is only half of


ABSTRACT Between 2001 and 2021, the eight iwi of Taranaki entered into Deeds of Settlement with the Crown. These settlements, which saw the Crown acknowledge and apologise for its historical breaches of Te Tiriti o Waitangi, also served to extinguish the rights of Taranaki Māori to seek further redress from the Crown. The Treaty Settlement process over, Taranaki Māori and the many non-Māori that have settled in the rohe (tribal territory) are left to themselves to deal with any lingering tensions, ongoing enmity and forms of structural injustice stemming from the settler-colonial process. This paper is not about the formal processes of colonisation or Crown-initiated attempts to atone for the past through the Treaty Settlement process. Rather, this paper concerns the painstaking work of change undertaken on the ground by local people, Māori and non-Māori alike. It concerns the 'small stories' of colonisation, the myriad endeavours of local people working for change in local contexts. In particular, the article concerns the fight for Māori wards on Councils in New Plymouth and South Taranaki, and the extraordinary work done by ordinary people in attempting to forge some kind of future of togetherness in a region riven by the violence of colonisation.


deweloped state of the genital system, and he considered this same condition would also render litholapaxy a safe operation during early lie The elasticity of the arethra wa also favourable for thie manipuIation of the lithotrite.-Mr. CORLY said that last year he had had an interview with Surgeon-Major Keegan, of the Indian Medical Service, who has made litholapaxy a special study. That gentleman thought that the most extreme youth was no contra-indication to the opation, and tbat even in infancy the only difficulty to overcome was that of obtaining a trustworthy instrument sufficiently smalL When that difficulty should be overcome, he exFected that the operation could be done in the youngest infant in whom stone might be found.


This paper is concerned with the activities of one of the leading merchants of Bombay and his associates, in the early years of the nineteenth century. It sees these activities within a specific historical situation, that of the developing colonial economy in western India. We hope to form a clearer view of the entrepreneurial environment of the region. At the same time, it may be possible to see some of the ways in which business activity in this part of India supported the mercantile and credit institu-


Medog is well known as the last county with available public transportation in China. Although it has very lush vegetation, our knowledge on plants of Medog is very limited because the poor transportation condition impeded comprehensive botanical survey in this area. Here we gave a brief summary of the study history on flora of Medog, and then introduced some plants with special scientific virtue, which had been collected during our recent trip to Medog.


We present the application of a distinctive feature selection method based on neural networks to the problem of intrusion detection, in order to determine the most relevant network features. We use the same procedure for feature selection and for attack detection, which gives more consistency to the method. We apply this method to a case study and show its advantages compared to some existing feature selection approaches. We then measure its dependence to the network architecture and the learning


We found a new class of analytic soliton solutions that describe the parametric wave mixing of optical pulses in quadratic nonlinear crystals. We analyze the stability properties, interactions and collisions of these solitons


The aim of the paper is to give the insight into international business and management in pandemic-related conditions in the first half of 2020. The subject of the paper is the analysis of the impact of the initial pandemic wave on the conditions in which international business and management take place and the risks to which companies are exposed, the ways they react to these conditions regarding the business ventures they give up or undertake, as well as the possibilities of how to cope with the current pandemic conditions. Therefore, the paper consists of three parts which analyze each of these aspects. In the pandemic-related conditions, full of unknowns and declining trends of almost all economic indicators, managers have a significant and additional responsibility to consider all relevant aspects and act accordingly making possibilities to mitigate the effects of a pandemic and to get through it.


Deep neural networks have become a ubiquitous tool for mastering complex classification tasks. Current research focuses on the development of power-efficient and fast neural network hardware accelerators for mobile and embedded devices. However, when used in safety-critical applications, for example autonomously operating vehicles, the reliability of such accelerators becomes a further optimization criterion which can stand in contrast to power-efficiency and latency. Furthermore, ensuring hardware reliability becomes increasingly challenging for shrinking structure widths and rising power densities in the nanometer semiconductor technology era. One solution to this challenge is the exploitation of fault tolerant parts in deep neural networks. In this paper we propose a new method for predicting the error resilience of neurons in deep neural networks and show that this method significantly improves upon existing methods in terms of accuracy as well as interpretability. We evaluate prediction accuracy by simulating hardware faults in networks trained on the CIFAR-10 and ILSVRC image classification benchmarks and protecting neurons according to the resilience estimations. In addition, we demonstrate how our resilience prediction can be used for a flexible trade-off between reliability and efficiency in neural network hardware accelerators.


Abstract Educational practices in South Africa which privilege English throughout the educational journey of the learner disadvantage the majority who do not speak English as a home language. Tertiary institutions in South Africa have crafted language policies that appear to be attempts to redress this imbalance by pledging improved learning opportunities in some African languages. In many areas, it can be seen that these policies have not been implemented, perhaps indicating a lack of will to do so. The SA Constitution requires provision in particular languages only when it is 'reasonably practicable' to do so. Similar or identical caveats appear in the language policies of the University of Johannesburg and UNISA allowing for inaction. It is questionable whether tertiary institutions acting unilaterally rather than as part of a coordinated status, corpus and acquisition planning can achieve transformation in the academy. Removing the 'reasonably practicable' caveat from the Constitution and establishing a national language planning body will be necessary before widespread transformation can occur. Language-in-education policies linked to financial reward and penalty mechanisms may be required to achieve tangible progress towards multilingual tertiary education.


Research progress on Ainsliaea pertyoides was summarized from the aspects of habitat,distribution,uses as medicine,original plant identification and chemical components.Ainsliaea pertyoides was widely used as medicine in orthopaedics,had evident curative effect and good development prospect,but the research available was very little.Further studied should be done on the quality control,active ingredients and associated pharmacological research.


See Article by Sood et al

Implantation of cardiovascular implantable electronic devices has increased steadily since their debut some 60 years ago with estimates of 1.2 to 1.4 million devices implanted annually worldwide.1 Currently, the vast majority of these cardiovascular implantable electronic devices use leads that provide a direct electrical connection from the pulse generator to cardiac tissue. Inevitably, the incidence of lead extraction has increased concurrently and in recent years has even exceeded the increase in implants. The interaction between the leads and the body is best thought of as a dynamic substrate by virtue of the degree of tissue ingrowth (making removal more difficult over time), increasing likelihood of venous occlusion with increased dwell time (necessitating lead extraction to gain access for system upgrade or lead replacement), as well as the lead's position as the electromechanical weak link in modern cardiovascular implantable electronic device systems.

Current literature on lead extraction safety and outcomes is limited by a few factors. First, lead models change through time, and significant evidence exists that the likelihood of fracture and possibly even extraction-related morbidity and mortality is dependent on the lead model and architecture.1–4 Therefore, existing evidence may not apply to future (or even current) leads requiring extraction. Furthermore, although extraction, as defined as removal of a lead in place for >1 year or requiring specialized tools for removal, occurs at centers with various clinical volumes and by operators with various levels of experience, most published reports of lead extraction outcomes are from a few high-volume centers with highly experienced operators.2,4–8 When lead extraction has been studied at centers of various sizes, the incidence of major adverse events showed an inverse correlation with institutional volume, suggesting that real-world complication rates likely exceed published data. …


Purpose: Children with severe anorectal malformation, after anorectoplasty, frequently have faecal soiling, which is disruptive functionally and psychosocially. Post-operative bowel management program involves multimodality treatment including drug manipulation, laxative enema and pelvic muscle training. The results of pelvic muscle biofeedback exercise are reviewed.

Methods: Patients with anorectal malformation after anorectoplasty were followed-up at continence clinic with symptom scoring (Rintala score). Co-operative patients with problematic soiling were selected for biofeedback treatment program. Pelvic musculature anatomy and physiology were assessed by anorectal manometry, magnetic- resonance imaging and transrectal ultrasonography. They received active pelvic musculature stimulation and biofeedback training of pelvic muscle (Myoexorciser 1000 Biofeedback System – VERIMED, Florida, USA). Duration of treatment ranged from 3 to 6 months. Outcome was measured by incontinence score, manometry and electromyogram of pelvic muscle.

Results: Eight boys, aged 5–11 years, completed the biofeedback program. Soiling frequency dropped significantly post treatment (P=0.0431). Electromyogram of pelvic muscle improved (P < 0.05). Overall symptom-score confirmed functional improvement.

Conclusions: Biofeedback training program benefits children with intractable soiling after surgery for severe anorectal malformation. Follow up studies are required to confirm whether the benefit is sustained in the long term.


Abstract : The report summarizes research on the syntax and semantics of natural languages. Empirical data were collected in the form of corpora from children speaking English, French, and Mandarin Chinese. Probabilistic grammars were written for the corpora. In addition, the model-theoretic semantics of the utterances was studied. A number of classical semantical issues were considered in relation to the corpora collected: the logic of propositional attitudes, the use of quantifiers, de re and de dicto modes of reference, the logic of definite descriptions, the logic of indefinite descriptions.


Abstract This article described the development and utilization of a CAN-bus based robot tractor. A RTK-GPS and an IMU were utilized as a position and a posture sensor for the development of a navigation system. The path planning and navigation control method were described in this article. Three field tests were conducted to show the performance and stability of the robot on straight path, logged path following crop rows and long time work. The RMS value of lateral and heading errors of three tests were 0.05 m and 0.6 degree, 0.02 m and 0.77 degree, 0.04 m and 0.75 degree, respectively. The results revealed the CAN-bus based robot tractor has high and stable navigation accuracy. The accuracy was acceptable for all tests.


This article explores the extent to which supply chain practices are implemented by light vehicle manufacturers in South Africa and determines whether there are differences with reference to supply chain practices between manufacturers of different origin (parent companies) in South Africa. A survey was conducted on light vehicle manufacturers in South Africa, using face-to-face questionnaire based on purposive sampling technique. Data was analysed descriptively using Statistical Package for Social Sciences (SPSS) and the findings reveal that overall, light vehicle manufacturers implemented supply chain practices to a great extent. The most highly implemented practices were "building long-term relationships", "cooperation to improve process" and "collaboration on new product development". "Sharing supply chain risk" was the least implemented across the inbound, outbound and internal supply chain. The article also revealed that in few of the best practices, differences were found between manufacturers of European and Asian parent company origin (parent companies of origin).


This activity covers the process of choosing and preparing equipment for live packing and transportation of stock. It focuses on equipment and processes for packing and transporting fingerlings, adult fish and crayfish.


The present study was undertaken to assess the extent of horizontal diversification comprising different growth rate of agri-horticultural crops along with livestock and fish production in the hilly and terai region of West Bengal for the period of 2003–2015. The study was measured based on cumulative annual exponential growth rate (CAEGR) including Simpsons Diversity Index (SID). The study revealed that the area under food grains in the both the region has declined and the area under finer cereals has also increased but the increase in SID values signifying shift towards non-food grain crops like fruits, flowers, vegetables, etc. along was clearly observed. The highest level of extent in increase of SID values was found in flowers (8.96) in hilly and (4.20) in terai region. In hilly region, there has been an extent of decrease in SID values in terms of different livestock and fish production. While, in terai region, it is observed that there has been an extent of increase in SID value in terms of different livestock and fish production. In contrast, growth rate of area under the production of different agri-horticultural crops and livestock and fish production was found positive in hilly region. On the other hand, in terai region, it is revealed that the growth rate of area under the major horticultural based crops likes vegetables and fish production was found negative. Growth rate of area under agricultural crops and livestock production was found positive.


The instrumental character and the interdisciplinary study of Literature, especially Literary Theory, together with the analytical skills that reading literary texts provides, constitute an adequate route for the integration of Humanities, both in the area of scientific investigation, and in teaching, which at the same time supports the structure of human development on all of its different educational levels.


The `Beyond 3G Wireless Networks Architecture' proposes to assimilate numerous heterogeneous wireless network technologies over an Internet Protocol Backbone. However, in order to offer seamless mobility, cost - effective connectivity and desired Quality of Service (QoS) in such a diverse environment; efficacious vertical handover support still remains a major design challenge. In this research/manuscript, a novel handover decision mechanism, `Travelling Time Prediction Based on the Consecutive RSS Measurements' in an IEEE 802.11 WLAN cell is suggested. The method uses a time threshold which is computed by a Mobile Terminal (MT) as soon as it penetrates into a WLAN boundary. The estimated travelling time is then compared with the time threshold, so as to make handover decisions for minimizing the probability of unnecessary handovers. Our performance analysis reveals that the suggested mechanism effectively reduces number of unnecessary handovers by 60% as compared to the already proposed schemes.


The damag creto a 220KV electromagnet'ic voltagetransformer (EMVT)due to sustained over-voltage on switch-offby a circuit breaker-(CB)fittedwithgradingcapacitors, and subsequentstudiesfor thesteady-state periodhavealreadybeenreported[ Ti. In thispaper,thepre-steadystateperiod is analyzedand excellentagreementshownbetweenfieldand analyticalresults.The concernedparametersfor variousmakesof CB's, EMVT'sand bus-barcapacitancehavebeen collectedand a.numberof studiesconducted. It is concludedthatthe controlof.theEMVT saturationcharacteristic is superiorcomparedto the measuressu,ggested earlierto preventsuchover-voltages. A suitablesaturationcharacteristic for theworstcasehas been identified.


The Psychology of Religion has, since its inception, been caught between the positivisticreductionistic strivings of modern scientific aspirations and the humanistic and holistic visions of theology. At the heart of this ambivalence exist different conceptions of the nature of man. Current shifts from behavioristic, adjustmental, and mental health models to humanistic and actionistic formulations provide the opportunity for a rapprochement of theological and psychological principles. The integration of these ideas in a "Theological-Psychology of Religion" is viewed as offering new theoretical foundations for the development of a rigorously based empirical religious psychology-one with solid footing in objective research, but which is not detached from explicit theological values. Historically, man per se was the province of religion. The growth of biological science and medicine seemed to reduce human life to the level of a complex machine, while the advent of psychology tended to abstract man from his worldly and possible other-worldly contexts and turned him in upon himself. Thus it was that Freud (1856) theorized that religion was a normal product of psychic development to be cast aside with the coming of maturity. William James (1908:299-300) put faith in the pragmatic mold by stating: "if the hypothesis of God works satisfactorily . . . it is true." As one wag put it, psychology first lost "its soul, then its mind, and then consciousness; but strangely enough it still behaves" (Baker, 1963:1). The foregoing remarks suggest an historical process by means of which man became dehumanized, as science usurped him from religion. In the framework of current psychology, this decline has resulted in the study of logical constructs and/or intervening variables, not of man himself. Hence, some troubled psychologists have asked in puzzlement, "Where is the perceiver in perception, and the learner in learning?" The shift from absolutist to relativistic physics further reduced the significance of man from at least a fairly well circumscribed object of study to one floating in a contingent universe. The process of trivializing man has not occurred without resistance. Hume (Becker, 1968: 22) countered the Newtonian world view by asserting that "the science of man is the only solid foundation for the other sciences." In a similar vein, Diderot (Becker, 1968:3) claimed that "it is the presence of man that renders natural existence interesting. Man is the unique end from which we must begin and to which everything must return." Indeed this is the problem-to formulate a systematic view which without qualification acknowledges the human component in the social and behavioral sciences. VALUATIONS IN THE PSYCHOLOGY


The screening and introduction of more high-quality rootstock is the key technology to solve the continuous cropping obstacle,taking Zaoqingqie(CK)as the scion which was grafted on three varieties of eggplant rootstocks respectively including Qiezhen 1,Tuolubam and Tuotuosijia,and the effect of grafting were analyzed.The results showed that the survival rate of three grafting were high.Compared with the control,the grafted plants exhibited delay of first harvesting time,early yield was significantly reduced and showed significant higher of disease-resistance and output.Grafting had less impact on quality of scion.All of above,Tuotuosijia,Qiezhen 1and Tuolubam could be used interchangeably in local agricultural production as excellent rootstocks.


The process of industrialization and urbanization b ri gs industrial structure and city layout changes. Consequently, manufacture factories retrea t from urban area and leave sites as legacy, which are threatened by the presence or potential presence of contamination. These sites could be recognized as Brownfield, a concept that is being widely accepted internationally. Landscape design as well as other remediation practice is directly impacted by manage ment strategies. The environment protection agency of Beijing takes the lead on the remediation managemen t strategy development on the background of underdeveloped system of legislation, management an d standards in China. This article tends to explore the latest development of management strategies rose by Beijing environment protection agency.


Introduction: Translocations involving the MLL gene on chromosome 11q23 result in fusions with ≥10 partner genes that act as drivers in relatively chemotherapy resistant MLL-rearranged (MLLr) leukemias. These chimeric proteins form part of protein complexes that aberrantly upregulate transcription of the leukemogenic HOX and MEIS1 genes. Menin is a key member of the complex and localizes the complex to chromatin. Similarly, in NPM1 mutant (mNPM1) AML, the interaction between wild-type MLL and menin leads to a HOX and MEIS1-mediated leukemogenic transcriptional program. In preclinical models of MLLr and mNPM1 leukemias, inhibition of the interaction between MLL and menin downregulates HOX and MEIS1 transcription and reverses leukemogenesis (Uckelmann 2020; Krivstov 2019). SNDX-5613 (5613) is a potent, selective protein-protein interaction inhibitor of menin being evaluated in the AUGMENT-101 study, a first-in-human (FIH), Ph 1/2 study in pts with R/R acute leukemia. Here, we report the results of the completed, Ph 1 component.
 Methods: The study includes 2 parallel dose-escalation cohorts: pts not taking (Arm A) or taking (Arm B) strong CYP3A4 inhibitors. An early amendment restricted enrollment to MLLr or mNPM1 leukemias. Dose escalation used a "rolling 6" design with expansion at efficacious doses. 5613 is dosed orally q12h in continuous 28-day cycles. Dose levels evaluated in Arm A were 113 (n=1), 226 (n=6), 276 (n=10), and 339 mg (n=8), and in Arm B 113 (n=16), 163 (n=6), and 226 mg (n=7). Primary objectives of Ph 1 were to determine the safety, MTD, recommended Ph 2 dose (RP2D), and PK profile of 5613. Exploratory endpoints included antileukemic activity and pharmacodynamics of 5613.
 Results: As of 29Jun2021, 54 pts had received at least 1 dose of 5613; 13 pts remained on treatment. Baseline characteristics are detailed in Table 1. The median age was 49 years; 82% (n=44) of pts had AML; 65% (n=35) had MLLr leukemia, and 19% (n=10) had mNPM1 leukemia. Pts had a median of 3 prior therapies (range, 1-12); 57% and 44% had prior venetoclax or transplant, respectively; 59% of pts had not responded to their most recent line of therapy.
 5613 exhibited dose-proportional PK, and exposure increased ~2-3-fold when given with a strong CYP3A4 inhibitor. Measurement of target occupancy and gene expression showed that 5613 disrupted menin binding to chromatin and decreased leukemogenic gene expression consistent with the established mechanism of action.
 The only DLTs were Grade 3 prolonged QTc; all events were clinically asymptomatic. The MTD was 276 mg q12h in Arm A and 163 mg q12h in Arm B; 2 doses in each arm met the protocol-defined criteria (safety, percentage of planned dose intensity, and pharmacokinetic exposure) for a RP2D. The frequency of Grade 3 prolonged QTc at these doses was 8% (3/38). No ventricular arrhythmias were reported, and no pts discontinued 5613 due to a treatment-related event. Other common (>10%) treatment-related AE (TRAE) were nausea (n=12; 22%), vomiting (n=9; 17%), differentiation syndrome (n=8; 15%), and diarrhea (n=6;11%). Grade ≥3 TRAE are shown in Table 2.
 In the 45 pts with MLLr or mNPM1 leukemias, responses were seen in both Arms A and B and at multiple dose levels. The composite CR (CRc: CR+CRh+CRp+CRi/MLFS) rate was 44% (20/45 pts) (Table 3). Among pts with MLLr leukemia, the CRc rate was 49% (17/35 pts) and in pts with mNPM1 leukemia, the CRc rate was 30% (3/10 pts); 14/20 (70%) pts with CRc achieved MRD negativity assessed locally by flow cytometry or PCR. Of 22 pts who received prior transplant, 10 (45%) achieved CRc. The CR/CRh rate was 22% (10/45) in pts with MLLr or mNPM1 leukemia. Median time to CR/CRh was 2 months (mo). With a median follow-up of 3.2 mo, the median duration of response (DoR) for patients achieving a CR/CRh was 5.2 mo. Responding patients were censored at the time they discontinued the study to proceed to an allogeneic stem cell transplant (n=6). Consistent with the proposed preclinical mechanism of menin inhibition, the 9 patients with wild-type MLL and NPM1 did not respond to 5613.
 Conclusion: In this FIH Ph 1 study, SNDX-5613 demonstrates an acceptable safety profile and promising antileukemic activity in pts with heavily pretreated R/R MLLr and mNPM1 acute leukemia. Two dose levels in each arm met the prespecified criteria for RP2D. Ph 2 expansion includes cohorts of pts with MLLr AML, MLLr ALL, and mNPM1 AML.
 Figure 1 Figure 1.

 Stein: Foghorn Therapeutics: Consultancy; Blueprint Medicines: Consultancy; Gilead Sciences, Inc.: Consultancy; Abbvie: Consultancy; Janssen Pharmaceuticals: Consultancy; Genentech: Consultancy; Jazz Pharmaceuticals: Consultancy; Bristol Myers Squibb: Consultancy; Celgene: Consultancy; PinotBio: Consultancy; Daiichi Sankyo: Consultancy; Astellas: Consultancy; Novartis: Consultancy; Agios Pharmaceuticals, Inc: Consultancy; Syros Pharmaceuticals, Inc.: Consultancy; Syndax Pharmaceuticals: Consultancy. Stone: Syndax: Membership on an entity's Board of Directors or advisory committees; Syntrix/ACI: Membership on an entity's Board of Directors or advisory committees; GlaxoSmithKline: Consultancy; Innate: Consultancy; Janssen: Consultancy; Gemoab: Membership on an entity's Board of Directors or advisory committees; Foghorn Therapeutics: Consultancy; Elevate Bio: Membership on an entity's Board of Directors or advisory committees; Bristol Myers Squibb: Consultancy; Boston Pharmaceuticals: Consultancy; BerGen Bio: Membership on an entity's Board of Directors or advisory committees; Astellas: Membership on an entity's Board of Directors or advisory committees; Arog: Consultancy, Research Funding; Jazz: Consultancy; Onconova: Consultancy; AbbVie: Consultancy; Novartis: Consultancy, Research Funding; Syros: Membership on an entity's Board of Directors or advisory committees; Aprea: Consultancy; Amgen: Membership on an entity's Board of Directors or advisory committees; Actinium: Membership on an entity's Board of Directors or advisory committees; Takeda: Consultancy; Agios: Consultancy, Research Funding; Celgene: Consultancy; Macrogenics: Consultancy. Arellano: KITE Pharma, Inc: Consultancy; Syndax Pharmaceuticals, Inc: Consultancy. Rosen: Syndax: Current Employment. Meyers: Syndax Pharmaceuticals, Inc: Current Employment, Current equity holder in publicly-traded company, Current holder of individual stocks in a privately-held company, Patents & Royalties; Nuvalent: Consultancy, Membership on an entity's Board of Directors or advisory committees. Huang: Syndax: Current Employment, Current equity holder in publicly-traded company, Current holder of stock options in a privately-held company; Serapta: Ended employment in the past 24 months. Smith: Syndax: Consultancy; Tempest: Current holder of stock options in a privately-held company; Athira: Current holder of stock options in a privately-held company. Bagley: Syndax: Current Employment, Current equity holder in publicly-traded company, Current holder of stock options in a privately-held company; Radius Health: Ended employment in the past 24 months. Thirman: AbbVie: Consultancy, Other: TRAVEL, ACCOMMODATIONS, EXPENSES (paid by any for-profit health care company), Research Funding; Adaptive Biotechnologies: Consultancy; AstraZeneca: Consultancy; Celgene: Consultancy, Other: TRAVEL, ACCOMMODATIONS, EXPENSES (paid by any for-profit health care company); Pharmacyclics: Consultancy, Other: TRAVEL, ACCOMMODATIONS, EXPENSES (paid by any for-profit health care company); Merck: Research Funding; Syndax: Research Funding; TG Therapeutics: Research Funding. Patel: Ignyta: Research Funding; Incyte: Research Funding; Jacobio: Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees, Research Funding; Jounce Therapeutics: Research Funding; Klus Pharma: Research Funding; Kymab: Research Funding; Loxo Oncology: Research Funding; LSK Biopartners: Research Funding; Lycera: Research Funding; Mabspace: Research Funding; Macrogenics: Research Funding; Merck: Research Funding; Millennium Pharmaceuticals: Research Funding; Mirati Therapeutics: Research Funding; ModernaTX: Research Funding; ORIC Pharmaceuticals: Research Funding; Pfizer: Membership on an entity's Board of Directors or advisory committees, Research Funding; Phoenix Molecular Designs: Research Funding; Placon Therapeutics: Research Funding; Portola Pharmaceuticals: Research Funding; Prelude Therapeutics: Research Funding; Qilu Puget Sound Biotherapeutics: Research Funding; Revolution Medicines: Research Funding; Ribon Therapeutics: Research Funding; Seven and Eight Biopharmaceuticals: Research Funding; Syndax: Research Funding; Synthorx: Research Funding; Stemline Therapeutics: Research Funding; Taiho: Research Funding; Takeda: Research Funding; Tesaro: Research Funding; TopAlliance: Research Funding; Vedanta: Research Funding; Verastem: Research Funding; Vigeo: Research Funding; Xencor: Research Funding; Exelixis: Membership on an entity's Board of Directors or advisory committees; Bayer: Membership on an entity's Board of Directors or advisory committees; Pharmacyclics: Membership on an entity's Board of Directors or advisory committees; Abbvie: Membership on an entity's Board of Directors or advisory committees; Alexion, AstraZeneca Rare Disease: Other: Study investigator; Hutchinson MediPharma: Research Funding; Hengrui: Research Funding; H3 Biomedicine: Research Funding; Gilead: Research Funding; GlaxoSmithKline: Research Funding; Genentech/Roche: Membership on an entity's Board of Directors or advisory committees, Research Funding; Forma Therapeutics: Research Funding; Evelo Biosciences: Research Funding; Eli Lilly: Research Funding; EMD Serono: Membership on an entity's Board of Directors or advisory committees, Research Funding; Effector Therapeutics: Research Funding; Daiichi Sankyo: Research Funding; Cyteir Therapeutics: Research Funding; Curis: Research Funding; Clovis: Research Funding


${\mathrm{C}}^{13}(\ensuremath{\alpha},\ensuremath{\alpha}){\mathrm{C}}^{13}$ cross sections at center-of-mass angles 54.7\ifmmode^\circ\else\textdegree\fi{}, 107.9\ifmmode^\circ\else\textdegree\fi{}, 142.6\ifmmode^\circ\else\textdegree\fi{}, and 169.6\ifmmode^\circ\else\textdegree\fi{} and ${\mathrm{C}}^{13}(\ensuremath{\alpha},n){\mathrm{O}}^{16}$ cross sections at 0\ifmmode^\circ\else\textdegree\fi{} have been measured at $\ensuremath{\alpha}$-particle energies from 2 to 3.5 MeV. From dispersion-theory analysis, a consistent set of ${J}^{\ensuremath{\pi}}$ and partial-width values has been obtained for eleven states of the compound nucleus ${\mathrm{O}}^{17}$ with excitation energies between 8 and 9 MeV.


Abstract A computational noise study of a scale model of an axisymmetric ideally contoured plug-nozzle (CPN) is presented. The CPN has an exit diameter of 45 mm and the geometrical configuration is such that the jet flow is shockless at the design pressure ratio, ξ d =3·62. The gas dynamics of the jet flows has been predicted using the NPARC Computational Fluid Dynamics code with the k -ϵ turbulence model. The gas dynamics data are then used to perform the noise computations based on the modified General Electric MGB code. The study covers a range of pressure ratios, 2·0≤ξ≤5·0. The agreement of the computational aeroacoustic results with the reported experimental data is favourable. At the design pressure ratio (shockless flow), the predicted noise levels are within 3 dB. At the off-design pressure ratios (flows with shocks), the theory predicts the noise levels within 5 dB, except at very high frequencies for pressure ratios farthest from the design pressure ratio when deviations up to 8 dB are noted. The computed directivity patterns do not represent the reported experimental trends well. The mechanism of shock formation in the CPN jet flows is noted to be basically different from those in the convergent nozzle and convergent–divergent nozzle jet flows. The computational results indicate consistent noise reduction effectiveness of the CPN relative to the equivalent convergent and convergent–divergent nozzles for all operating pressure ratios.


This research looks for identifying the reasons why some students with curricular modification and learning disabilities get successful on their academicals tasks although they experiment lots of problems for their adaptation at high school. For that reason, this study compares characteristics of students both with and without curricular modification and learning difficulties, through out the application of a structured instrument about academic-cognitive and social-emotional resources over two hundred fifty one students from public, academic and urban high schools. This study shows that students with curricular modification give more importance to family and teacher's support, and they can show more tolerance to frustration.


Nepal's Tenth Plan (2002-2007) (Nepal 2003b) serves as Nepal's Poverty Reduction Strategy Paper (PRSP) and outlines the country's plan for reducing poverty from 37 percent to 30 percent. Although Nepal has promoted a progressive forest policy that attempts to address the needs of rural people, more needs to be done to address poverty alleviation and equity. Nepal's 20-year-old community forestry program, through which local people are given the right to manage their local forests, has served as a model for other forestry programs.


After 9/11, American officials authorized numerous contentious counterterrorism practices including torture, extraordinary rendition, indefinite detention, trial by military commission, targeted killing, and mass surveillance. While these policies sparked global outrage, the Bush administration defended them as legally legitimate. Government lawyers produced memoranda deeming enhanced interrogation techniques, denial of habeas corpus, drone strikes, and warrantless wiretapping lawful. Although it rejected torture, the Obama administration made similar claims and declined to prosecute abuses. This book seeks to understand how and why Americans repeatedly legally justified seemingly illegal security policies and what this tells us about the capacity of law to constrain state violence. It argues that legal cultures shape how political actors interpret, enact, and evade legal norms. In the global war on terror, a culture of legal rationalization encouraged authorities to seek legal cover—to construct the plausible legality of human rights violations—in order to ensure impunity for wrongdoing. In this context, law served as a permissive constraint, enabling abuses while imposing some limits on what could be plausibly legalized. Cultures of legal rationalization stand in contrast with other cultures prevalent in American history, including cultures of exception, which rely on logics of necessity and racial exclusion, and cultures of secrecy, which employ plausible deniability. Looking forward, legal norms remain vulnerable to manipulation and evasion. Despite the efforts of human rights advocates to encourage deeper compliance, the normalization of post-9/11 policy has created space for the Trump administration to promote a renewed culture of exception and launch bolder attacks on the rule of law.


Bio-filtering is mostly used in biological purification technology to purify low concentration waste organic gas. To improve performance of that system, the mapping relation between the process parameters and the purification efficiency must be identified, which is usually accomplished by setting up complex mathematic models between the parameters and the purification efficiency. In this paper, an extension evaluation method applying dependent function and idea of fuzzy math is proposed to evaluate the purification efficiency of the waste organic gas in the trickling bio-filter. The method is easy to be implemented by computer program and computing results prove its effectiveness.


This Guide will provide information on processes, procedures and policies with regards to research data management (RDM), as well as access to resources and tools that can support researchers in managing their data. This section provides information on data citation


Boletinellus merulioides forms abundant sclerotia in nature throughout its range in eastern North America. Sclerotia collected in the forest germinated to form mycelial colonies which had the same appearance and microscopic characteristics as colonies derived from sporocarps. Sclerotia which had overwintered in the forest were viable in the spring.


ABSTRACT Service quality has received considerable attention from marketers. However, current measures of service quality do not adequately capture customers' perceptions of service quality for highly service oriented technical products retailing. This study explored the usefulness of SERVPERF, the perceptions component of SERVQUAL and a retail service quality scale (the DTR scale, proposed by Dabholkar et al. 1996) in measuring the service quality of electronic goods retailers, where service is an important component. Results indicate that SERVPERF is slightly better than the DTR scale. A modified scale comprising selected items from both scales was generated by factor analysis on the data collected. Five factors, namely 'Service Personnel,' 'Physical Aspects,' 'Merchandise,' 'Confidence' and 'Parking' consisting of a total of 21 items were derived. Results of the modified scale (termed herein SERVPERF TPR) measured the service quality of electronic retailers slightly more effectively than either the DTR or SERV-PERF scales.


The aim of this paper is to analyze how the answers to the questions of strategic thinking can be a critical factor in business competitiveness and contribute to the success of it, considering as the theory based on industry and resource-based theory. The mother made is questioning how can you maintain the strategic mindset when evaluating the objectives and resources of the company with respect to the forces governing competition? The method used was to build an analytical relationship between strategic thinking and competitive forces to design strategies that allow internal resources considering the execution or turn contribute positively affect profitability.


The originality and flexibility of the physical modelling synthesizer
Modalys is being continously validated by an ever-growing community
of users made up by composers, acousticians and musicologists alike.
In this paper we will present the main lines that have oriented
recent research around Modalys. These can be summarized: (1)
Exploration and tentative classification of the musical possibilities
of Modalys. (2) Use of modal synthesis as a meeting point between
signal synthesis and physical modelling synthesis. (3) Port of
Modalys to a real-time platform.


A cobweb model in a singular differential equation form with multi-products and time-delay effects is established.Then,a delayed singular differential inequality is established.Based on analyzing the existence of the equilibrium point of the model,some sufficient conditions on the exponential stability are obtained and the exponential convergence rate is estimated.


Dorizzi et al. want to point out the meaning of different distributions of alanine aminotransferase (ALT) activity among women and men in screening blood donors. It is well established that the prevalence of elevated ALT shows geographic variation and is-significantly associated with gender, age and body weight [l, 21. Nonetheless, a common cut-off level for female and male donors has so far generally been set in the countries using donor ALT as a surrogate marker, probably mainly for practical reasons. In our study, we detected 9 (3 female, 6 male) antiHCV seropositive (RIBA-4, Ortho) donors to transfusion recipients who contracted hepatitis C. Their ALT levels were determined at 37 "C according to the recommendations of the Scandinavian Society for Clinical Chemistry and Clinical Physiology [3] and were as follows: 32,33 and 224 IU/I among the female and 28,40,58,63,78 and 128 IU/l among the male infectious donors. In Finland, new and also gender-specific ALT reference values have since March 1991 been adopted in the hospital laboratories in association with the introduction of the ALT assay recommended by the European Committee for Clinical Laboratory Standards (ECCLS). According to the new reference ranges (10-35 IUA in females and 10-50 IU/1 in males) and calculated that the ECCLS method gives 1.21.4 times higher values than the old one, all the 3 female infectious donors would have showed abnormal ALT results, 1 of the male infectious donors would have had a normal and another a borderline result. Thus, gender-specific reference ranges undoubtedly increase the predictive value of ALT, especially among females. Still, according to our experience, ALT is clearly inferior to anti-HCV both in specificity and also in sensitivity in primary donor screening to prevent posttransfusion hepatitis.


In Minangkabau the role of ninik mamak, mamak and kamanakan is very important. For example, when there is a problem between communities, it is Ninik Mamak who will handle it. So what's the difference between ninik mamak and mamak? So Ninik mamak consists of several penghulu, existing tribes, while the mamak is the mother's brother. Ninik mamak are elders in the tribe and in their nagari, usually ninik mamak are traditional leaders in Minang whose leadership is usually traditional, the position of ninik mamak is usually different, some are equal and some are tiered. This article aims to determine the role of ninik mamak, mamak and kamanakan both in terms of function and meaning. Method From writing this article using the library, namely reading existing sources such as articles related to the theme. In Minang, the role of mamak is very important to the child. Mamak, will teach all things about the norms that exist in the family, with that kamanakan who will carry on for the next if Mamak is no longer there. and the mamak acts as a protector for her sisters and keeps the inheritance, then as a mamak, she must set a good example for her kamanas so that her kamanas will emulate her mamak's attitude. With a good upbringing from mamak then kamanakan will be noticed by the community


Employing the "off-on" switching of the spirocyclic moiety in rhodamine B derivatives, two highly selective and sensitive probes for Fe3+ were prepared and confirmed by X-ray crystallography. An obvious fluorescent enhancement was observed in the presence of Fe3+, accompanied by significant color changes, which can be used for "naked-eye" detection. Moreover, confocal laser scanning microscopy experiments have proven that the probes were successfully used for fluorescence imaging in HepG2 cells.


Positive end‐expiratory pressure (PEEP) valves are used together with self‐inflating bags (SIB) to provide a preset PEEP during manual ventilation. It has recently been shown that these valves deliver highly variable levels of PEEP. We hypothesised that material fatigue due to repeated thermo‐sterilisation (TS) may contribute to varying reliability of PEEP valves.


In this paper, a compact model for the negative bias temperature instability (NBTI) is developed by considering the interface-state generation and the hole-trapping mechanisms. This model shows accurate reproduction of the threshold voltage (Vth) degradations measured from samples fabricated with different dielectric materials as well as processes. A total of eight model parameters are introduced for describing the different degradation origins. The parameter values are verified to exhibit universal properties as a function of the electrical field within the gate oxide (Eox). By implementing the universal NBTI model into the compact model HiSIM, the dynamic NBTI effect and circuit performance degradation can be predicted.


This paper presents experimental and numerical study of the effect of the environment on the frequency response of a piezoelectric device. The intent is to highlight the key elements to be taken into consideration when selecting or designing a resonance frequency tracking system. The studied specimen is a ring shaped PZT based material. Measurements in free vibration conditions using a frequency response analyser are done to investigate the effect of the applied voltage amplitude (DC and AC) and the material temperature on its frequency response. The material is then putted within a structure made of steel and polytetrafluoroethylene (PTFE) parts. Mechanical stress is applied using a compression machine to the structure, and its effect on the frequency response is measured. A finite element based model is introduced in order to explain the observed stress-effect. At the end a resonance frequency tracking system based on the zero phase angle control is discussed.


Perturbative thermal diffusivity has been measured on Alcator C-Mod via the use of the extended-time-to-peak method on heat pulses generated by partial sawtooth crashes. Perturbative thermal diffusivity governs the propagation of heat pulses through a plasma. It differs from power balance thermal diffusivity, which governs steady state thermal transport. Heat pulses generated by sawtooth crashes have been used extensively in the past to study heat pulse thermal diffusivity (Lopes Cardozo 1995 Plasma Phys. Control. Fusion 37 799), but the details of the sawtooth event typically lead to non-diffusive 'ballistic' transport, making them an unreliable measure of perturbative diffusivity on many tokamaks (Fredrickson et al 2000 Phys. Plasmas 7 5051). Partial sawteeth are common on numerous tokamaks, and generate a heat pulse without the 'ballistic' transport that often accompanies full sawteeth (Fredrickson et al 2000 Phys. Plasmas 7 5051). This is the first application of the extended-time-to-peak method of diffusivity calculation (Tubbing et al 1987 Nucl. Fusion 27 1843) to partial sawtooth crashes. This analysis was applied to over 50 C-Mod shots containing both L- and I-Mode. Results indicate correlations between perturbative diffusivity and confinement regime (L- versus I-mode), as well as correlations with local temperature, density, the associated gradients, and gradient scale lengths (a/LTe and a/Ln). In addition, diffusivities calculated from partial sawteeth are compared to perturbative diffusivities calculated with the nonlinear gyrokinetic code GYRO. We find that standard ion-scale simulations (ITG/TEM turbulence) under-predict the perturbative thermal diffusivity, but new multi-scale (ITG/TEM coupled with ETG) simulations can match the experimental perturbative diffusivity within error bars for an Alcator C-Mod L-mode plasma. Perturbative diffusivities extracted from heat pulses due to partial sawteeth provide a new constraint that can be used to validate gyrokinetic simulations.


In this paper, the basin stability of single machine infinite bus power systems with alpha-stable Levy type load fluctuations are investigated over the parameter space of mechanical power and damping parameter. The probabilities of returning to the stable equilibrium point are calculated for different characteristic exponent and skewness parameters of alpha-stable Levy noise to see the effect of impulsive and asymmetric load fluctuations.


The dynamics of extinction and diversification of life is not a simple random process, driven by arbitrary inputs. Biotic interactions are known to play a very important role in the population response to physical factors. In spite of this fact, it is not clear how the ecological scale is related with the macroevolutionary one. In this paper we suggest that both levels are, at least to some extent, decoupled. Using a simple model of large-scale evolution, we show how an n-species ecosystem evolves towards a critical state where extinctions of all sizes are generated. This state involves a situation where high unpredictability is present. The basic properties of the overall macroevolutionary pattern are well reproduced and a new interpretation for this process is suggested.


Japan is the world's largest importer of resources. In addition to its limited territory, it has a large population, and natural resources are already depleted, so that it relies heavily on foreign resources. Economic growth causes the demand for resources to increase at a commensurate rate. To meet the growing demand for resources, the deficit must be secured from abroad. As can be seen in Table 1, most of the vital resources show extremely high degees of foreign dependency which, moreover, show a tendency to rise rapidly.


We have studied the spectral behaviour of few-cycle soliton pulses in a non-resonant two-level atom medium by solving the full Maxwell-Bloch equations. It is demonstrated further that the carrier effects play an important role in the propagation of the few-cycle pulse laser. When the frequency detuning is not very large, both the population distribution and the refractive index of the medium follow the oscillatory carrier field instantaneously; in this case, carrier-wave compression or carrier shock occurs and a supercontinuum broader than that in the resonant medium may be generated. When the frequency detuning is large, the carrier shock is weak and the spectrum is not continuous, only showing an odd harmonic radiation.


China has now entered into the aging acceleration period, and the demand for medical care, elderly care, and health services is also greatly increased. In view of the nature of the "combination of medical treatment and care" and the modern medical model of "the combination of biological treatment and psychological treatment" in our hospital, our department has carried out clinical practice on hospice care. Supportive treatment of physical diseases in the elderly is our primary care service, while psychological support for family members is also an important part of our work. The medical staff in our department summarize and develop psychological support services for the dying elderly family members in the long-term clinical work, gradually developing a mature model and drawing the following conclusion: psychological support of hospice patients and their families is very necessary, feasible, and important and can be very effective to improve our service levels and clinician-patient communication. At the same time, hospice care services need the participation of doctors of many disciplines such as medicine, sociology, law, ethics, psychology, and pedagogy to promote the development of hospice care.

Key words:
Hospice care; Patients'family members; Psychological support


TV and broadcast not only are the main media of the Society but the important way to taking moral education to the mass especially to the adolesceat,passing culture and promoting harmonious development of the society.The adolescents wite greatil affected by TV and broadcast,has been increasingly paid close attention to. The mind and body can be grown hedthly and the society developed harmoniously by using the mediunl coneetly only when the duble aspects to the adolescents are ralizal fronter TV and broadcast.


The common indications for laparoscopic cholecystectomy are the same as those for the comparing open procedure. Despite the fact that laparoscopic cholecystectomy was initially saved for thin and young patients, it now is also presented to obese and elderly patients; actually, these concluding patients can advantage much more from surgery through small incisions. Laparoscopic cholecystectomy has rapidly become the procedure of choice for routine gallbladder removal and is currently the most commonly performed major abdominal procedure in Western countries. Trials have presented that laparoscopic cholecystectomy ABSTRACT


This research work examines the competing issues of energy consumption efficiency in wireless sensor networks. For this purpose, we considered a multi-objective Particle Swarm Optimization (PSO) in the selection of Cluster Head (CH) in such a way so that its energy is used uniformly with load balancing among clusters for delayed disintegration of network. LEACH algorithm based random clustering approach has been replaced by PSO clustering. The improved PSO protocol has been compared with random LEACH, Max Energy LEACH and k-means algorithm, and simple PSO which cluster only for space equi-distribution not for the load balancing among clusters., Wireless sensor network (WSN) is simulated using a MATLAB programming and power consumption algorithms take into consideration all aspects of power consumption in the operation of the node. Simulating different algorithm schemes on the same network system, same initial power sources, and routing protocol, an increase of overall system lifetime is demonstrated. The performance of PSO cluster based routing protocol shows improvements in lifetime but Max Energy LEACH perform better in network disintegration criterion


In order to research the effects of plastic deform ation on the electric property of the single crystal copper wire and the quantit ative relation between plastic deformation value and resistivity,the resistiviti es of various samples,which are drawn out from single crystal copper wire(Φ 8 mm ) and have different plastic deformation value,are measured precisely with four end down_lead.The results show:the resistivity of single crystal copper wire is rising along with the increasing of plastic deformation value.Its reason is that the distortion degree of the microstructure of single crystal copper wire will be aggravated while the plastic deformation value increases.


IC fabrication in nanometer technology nodes faces severe challenges in handling lithography hotspots due to edge placement error (EPE). These hotspots are particularly tackled by wire-spreading or rip-up and reroute during detailed routing, at the cost of more design iterations. They cannot be minimized unless a suitable routing penalty is imposed during global routing. In this paper, we present a new hybrid global route planning framework that follows floor planning. Since an accurate estimation of EPE on a net segment cannot be attained, we employ a routing penalty based on known simulation results, in order to identify a least cost routing path of a net across multiple metal layers. The results of our experiments on IBM HB floor planning benchmarks show an 4%, 53% and 74% improvement in net length, via count and worst case congestion respectively on an average.


The leading group of quality-oriented program for capital workers has worked out an education and training program 2007.The program is stated as follows: continue to carry out training on common ability,improve the mode of training;carry out training on Olympics and rural workers.In order to improve the overall quality of workers,it is of significance to provide the abundant education resources and create the conditions for study through integration of good education resources in society.


This is the first comprehensive introduction to the authors' recent attempts toward a better understanding of the global concepts behind spinor representations of surfaces in 3-space. The important new aspect is a quaternionic-valued function theory, whose "meromorphic functions" are conformal maps into quaternions, which extends the classical complex function theory on Riemann surfaces. The first results along these lines were presented at the ICM 98 in Berlin. An important new invariant of the quaternionic holomorphic theory is the Willmore energy. For quaternionic holomorphic curves in the quaternionic projective line, i.e., the conformal 4-sphere, this energy is the classical Willmore energy of conformal surfaces. Using these new techniques, the article discusses the mean curvature sphere of conformal surfaces in the 4-sphere, Willmore surfaces in the 4-sphere, Baecklund tranformations of Willmore surfaces, super-conformal surfaces and twistor projections, and a duality between Willmore surfaces in the 3-sphere and minimal surfaces in hyperbolic 3-space. Finally, a new proof of Montiel's recent classification of Willmore 2-spheres in the 4-sphere is given.


Collection appliance body exudates includes a collection pouch, comprising an adhesive wafer for attachment to the body, said adhesive wafer comprises a backing layer, a first adhesive material, and additional second adhesive wherein, said additional second adhesive comprises a combination of polar plasticising oil or a plurality of polar plasticising oil in content of 10 wt% of the final second adhesive, at least one polar polyethylene comprises a copolymer, the content of the polar polyethylene copolymer is 10-50% by weight of the final second adhesive, the polar polyethylene copolymer is 2g / 10min (190 ℃ / 21.1N ) having a melt flow index of less than.


without thought of self-interest. When IshmeDagan succeeded to the throne he wrote (and there is no reason to suspect his sincerity) a very cordial letter of announcement to his brother, professing all good feeling, disclaiming hostile ambition, and offering to join in a mutual oath of lasting brotherhood. Upon the whole one may suspect that the father's irate effusions give too low an opinion of his younger son, lower perhaps than he entertained himself in his cooler mood. Iasmakh-Adad


ABSTRACT When a situation could lead to multiple mutually exclusive consequences, recent research shows that people automatically generate multiple predictive inferences in memory. Several theoretical mechanisms have been proposed to account for the generation of predictive inferences. One hypothesis is that inferences are minimally encoded, represented only by a set of semantic features related to the inferences or by a more general concept that covers the consequences of both inferences. A second hypothesis is that activation of the inferences is delayed because it is initially weak and requires time to build. In three experiments designed to examine these two hypotheses, participants read narrative passages that supported mutually exclusive consequences. Predictive inferences were not detected in working memory using a word-naming task, even at longer delays, but were detected using a short-term contradiction paradigm and, therefore, available as part of the discourse representation. The combined results indicate that predictive inferences are minimally encoded rather than their activation being delayed.


The detailed study of GaN-BTG MOSFET where GaN is used as a substrate in lieu of silicon and at the gate terminal, a stacking of silicon dioxide (SiO2) and hafnium dioxide (HfO2) is placed in a conventional trenched gate structure to obtain the proposed device. This paper addresses the comparative study of electrical characteristics such as transfer characteristics, output characteristics, transconductance, higher-order transconductance, transconductance generation factor, output conductance has been obtained for the proposed device by performing simulation using TCAD. The results validate the superiority of the proposed device in terms of performance.


Despite nearly eight years of negotiating effort, the Doha Round of multilateral trade negotiations, launched in November 2001 under the auspices of the World Trade Organization (WTO), remains stalled. The agenda spelled out in the Doha Declaration was quite ambitious: it addressed not only traditional trade issues such as tariffs, but also new issues such as investment, competition policy, and environment. Unfortunately the breadth of the agenda contributed to disarray in the ensuing negotiations. In hopes of expediting talks, the General Council of the WTO subsequently dropped several controversial issues, among them competition policy, but the Doha talks are still deadlocked. TH E AN T I T R U S T BU L L E T I N: Vol. 54, No. 2/Summer 2009 : 327


An LCD is adapted to be manufactured using a significantly reduced number of masks and masking processes. In order to form a gate of the LCD, aluminum and one of molybdenum, tantalum, tungsten and antimony are sequentially deposited and patterned using a single mask. Cutting a shorting bar for preventing static electricity is performed while a passivation layer is patterned and rinsed. Accordingly, an LCD produced by this method includes a first metal layer, which includes a first contact hole and is disposed on a substrate, a second metal layer which covers the first metal layer and includes a second contact hole which is smaller than the first contact hole, an insulating layer, which covers the second metal layer and includes a third contact hole larger than the second contact hole, and a pad, which includes a conductive layer contacting the second metal layer through the third contact hole on the insulating layer.


The process of using 3A21 aluminium alloy cast-rolling stock producing strips for radiating fin is researched.The annealing institution of finished strip is determined.The soldering qualities of radiating fin are increased by adding Mg spalls in vacuo soldering furnace.


UVB radiation contributes to both direct and indirect damage to the skin including the generation of free radicals and reactive oxygen species (ROS), inflammatory responses, immunosuppression and gene mutations, which can ultimately lead to photocarcinogenesis. A plant‐derived flavonoid, baicalin, has been shown to have antioxidant, anti‐inflammatory and free radical scavenging activities. Previous studies from our laboratory have shown that in murine skin, Toll‐like receptor‐4 (TLR4) enhanced both UVB‐induced DNA damage and inflammation. The aim of this study was to investigate the efficacy of baicalin against TLR4‐mediated processes in the murine keratinocyte PAM 212 cell line. Our results demonstrate that treating keratinocytes with baicalin both before and after UV radiation (100 mJ cm−2) significantly inhibited the level of intracellular ROS and decreased cyclobutane pyrimidine dimers and 8‐Oxo‐2′‐deoxyguanosine (8‐oxo‐dG)—markers of DNA damage. Furthermore, cells treated with baicalin demonstrated an inhibition of TLR4 and its downstream signaling molecules, MyD88, TRIF, TRAF6 and IRAK4. TLR4 pathway inhibition resulted in NF‐κB inactivation and down‐regulation of iNOS and COX‐2 protein expression. Taken together, baicalin treatment effectively protected keratinocytes from UVB‐induced inflammatory damage through TLR pathway modulation.


[ANGLES]Nowadays, televisions offer a large set of useful tools and possibilities. Many of
them, like the internet connection, o er a wide number of options. This project is
intended to perfect some of them, speci cally the Electronic Programming Guide
(EPG). This tool presents the scheduled emissions of programs (events) for every
channel (service) in the television. EPG data is provided by broadcasters through
the antenna signal together with the multimedia contents of each channel.
This fact leads to two main problems. First, the quality and quantity of the
EPG information is very limited due to the lack of bandwidth. As a result, an event
extracted from the antenna signal contains only data referring to its schedule (start
and end time), a title and a brief description. The second issue arises when, in order
to obtain the complete EPG, it is necessary to tune every channel of the television.
Otherwise, the EPG will be displayed almost empty.
At the same time, there are specialized internet servers in charge of improving the
contents of the television guide. Some of the enhancements include structuring and
extending the title and descriptions of events, classifying the event by its category or
adding a snapshot of the program. However, these types of events are less accurate
in their schedule, since this information is updated along the time by broadcasters
and re
ected in the antenna signal.
Taking advantage of the internet connectivity of television, this project has created
an Smart Electronic Programming Guide (SmartEPG) combining the information
of di erent sources: antenna signal and internet server. In order to actually
extend the contents, the project has considered the di erences among antenna and
internet events, identi ed the similarities and combined the contents. As a result,
this document presents the development of the main components of the project
as well as an overview of the resulting guide presented using a new graphical user
interface.


Eddy current nondestructive testing (NDT) techniques are used widely in the nuclear industry for the detection of defects in a variety of critical power plant components. Modeling of the interaction between induced eddy currents, their corresponding magnetic fields and defects in the part under test can provide physical insight into eddy current NDT phenomena, and can also serve as a theoretical 'test-bed' for situations impossible to replicate experimentally. This paper describes the application of finite element analysis techniques to the modeling of eddy current nondestructive testing phenomena in power plant condenser tubing inspection. Finite element predicted eddy current signals are compared with experimental results obtained in the laboratory.


Purpose: This study therefore sought to analyse the interrelationship between the phenotypic and genotypic characteristics of methicillin-susceptible Staphylococcus aureus (MSSA) and MRSA strains isolated from healthcare workers in north-eastern Brazil.Patients and methods: Staphylococcus aureus strains were isolated from nasal mucosa of nursing professionals. They are identified by biochemical analysis and the sensibility drug test were carried out by agar diffusion method. Biofilm formation was detected on the polystyrene plastic surface. Molecular characterization was conducted by polymerase chain reaction (PCR). The Chi-squared or Fisher's exact tests were applied for the analysis of associations between phenotypic and genotypic characteristics.Results: A total of 118 workers were involved, 49.15% of whom presented S. aureus. The most frequently observed strain was resistance to penicillin (86.21%), while the inducible clindamycin resistance (iMLSB) phenotype was detected in 48.84% of isolates. MRSA was found in 41.37% of isolates, while SCCmec type I was seen in 75%. A strain with intermediate resistance to vancomycin was also found. In terms of virulence genes, eta, tst, pvl, spa, clfA, icaA, icaC and icaD genes were detected at least once. Biofilm formation was detected in 89.65% of the strains - 18.97% of these were classified as strongly adherent. No associations with ica genes were detected. Multivariate analyses of clusters demonstrated variability between the strains, with the notable formation of three main clusters, according to phenotypic and genotypic characteristics.Conclusion: High prevalence, multidrug resistance and presence of MRSA strains were all observed. Most isolates had significant virulence genes and the ability to form biofilms, increasing the severity of potential infections. It is therefore necessary to monitor the strains circulating in this hospital and to intensify precautionary measures in order to prevent their spread.


Pansharpening has been an important tool in remote sensing field, which is a process of providing multispectral images with higher spatial resolution. When dealing with WorldView-2 satellite imagery having more bands and higher resolution, most existing methods are not effective. In this paper, we propose a novel and effective pansharpening methods combing guided filtering and hyperspherical color transformation (HCT) for WorldView-2 images. We use panchromatic image as the guidance to further refine the intensity of multispectral data and also to extract the sufficient details from the panchromatic image itself. Moreover, the guided filtering and HCT integrated scheme can inject the extracted details into the multispectral data and the multispectral images can be sharpened all at once with an arbitrary order. The experimental results show that our proposed method can obtain high-quality pansharpened results and outperforms some existing methods.


A model of firepower optimization control of tank troop under information-based condition,which was based on command control system has been established.The striking process of tank troop has been presented,and the functions and representations of the modules of battlefield awareness,target evaluation,firepower optimization,damage evaluation,strike condition,etc.were analysed in-depth.An important reference for decision-making for combat command control was provided by the strike strategy(strike scheme strike condition)generated from firepower optimization control.


The tachinid genus Cholomyia presents Neotropical and Nearctic distribution with three species: C. acromion (Wiedemann, 1824), C. filipes (Walker, 1857), and C. inaequipes Bigot, 1884. In the present paper, all species are reviewed and redescribed, and a new species from Costa Rica is described, C. zumbadoi sp. nov. An identification key based on males is provided. For the first time, the male terminalia of


On February 15, we printed an article "Should Fang Min's Name Have Been Stricken from the Rolls?" which drew attention from our readership. Some readers pointed out most penetratingly: Was the Fang Min affair a public relations ploy on the part of the Guanghui Group? Will Fang Min be able to achieve what she wishes? What, in the final analysis, do people in various quarters think of Fang Min's job-hopping? With these questions in mind, I went expressly to Urumchi to do some interviewing.


Simple Summary Planaphrodes is a genus of Aprhodinae distributed in the Palaearctic region from Portugal to Japan. This paper reconstructs phylogenetic relationships among species of Planaphrodes based on morphological characteristics for the first time, elucidates the phylogenetic status of the genus and describes two new species found in China. Abstract A morphology-based phylogeny of the Holarctic leafhopper genus Planaphrodes Hamilton is reconstructed for the first time based on 39 discrete male adult morphological characters. The results support the monophyly of Planaphrodes, with the included species forming two monophyletic lineages defined mainly by the number and location of aedeagus processes. The position of Planaphrodes in the Aphrodini was resolved as follows: (Stroggylocephalus + (Anoscopus + (Planaphrodes + Aphrodes))). The fauna of Planaphrodes from China, Japan and Korea are reviewed and six species are recognized, including two new species: P. bifasciatus (Linnaeus), P. sahlbergii (Signoret), P. nigricans (Matsumura), P. laevus (Rey), P. baoxingensis sp. nov. (China: Sichuan) and P. faciems sp. nov. (China: Hubei). Acocephalus alboguttatus Kato, 1933 syn. nov. and Aphrodes daiwenicus Kuoh, 1981 syn. nov. are considered junior synonyms of Planaphrodes sahlbergii (Signoret, 1879). Planaphrodes bella Choe, 1981 is a junior synonym of Planaphrodes nigricans (Matsumura, 1912). A checklist and key to species of Planaphrodes are provided.


Fe-Ti oxide breakdown is frequently observed within hydrothermally altered dolerites in the Semnon Sb-Au district in the Variscan Armorican belt, France. Hydrothermal alteration has totally replaced primary ilmenite-hematite series minerals to rutile. Trace element analyses reveal some variations between parent minerals and their alteration product, characterized by a relative enrichment of Sb and W in rutile. For a better understanding of mineral replacement reactions, the redistribution of trace elements during the transition of ilmenite-hematite series into rutile was estimated by mass balance calculations. Comparison between the mean compositions of hydrothermal rutile and hydrothermal sulphide, from the same event, was also performed. Key findings from this work show that (1) almost all elements (especially Fe, Mn and Zn) are released from ilmenite-hematite series minerals during hydrothermal breakdown, (2) Sb and W are dominantly incorporated into the rutile structure from external fluid sources, (3) the Sb content of rutile evolves through time with sulphide precipitation as a result of Sb-partitioning and (4) the input of sulphur into the hydrothermal system controls the behaviour of Sb. Fe-Ti oxide breakdown is a key to understand Sb mineralisation.


This study examined age-related emotional responses and coping at the peak and the end of the SARS outbreak in Hong Kong. Three hundred and eighty-five Hong Kong Chinese, aged 18–86 years, rated the extent that they experienced 'shock', 'sadness', 'anger' and 'fear' in the face of SARS. They also completed selected items from Brief COPE (Carver, 1997). The results showed that older adults consistently experienced less anger than did their younger counterparts. Younger adults used more emotion-focused coping than did middle-aged and older adults at the peak of SARS; yet they exhibited the lowest increase in this form of coping throughout the outbreak, such that the age differences had reversed by the end of the outbreak. Findings of this study suggest that older adults may be better at emotional regulation than are their younger counterparts, they react to a crisis with less anger and are better able to adapt their coping strategies to the changing environment.


Based on geochemical analysis of ores,concentrates and tailings samples in Bainiuchang Ag Polymetallic Deposit,it's found that the contents of REs and REEs are low and the scattered elements(Ga,Cd and In)have comprehensive utilization value.Through studying the contents of REs,REEs and scattered elements in ores,concentrates and tailings,it's found that after processing,the contents of Cd and In are relatively enriched in Zn and Pb concentrates,while Ga is relatively enriched in tailings and REs and REEs are relatively enriched in Sn concentrates and tailings.The research on"Three Rare"metallic elements in the ores,concentrates and tailings have a great important guiding significance for future mining,processing and smelting.


The electrical properties of as‐grown and heat‐treated copper indium diselenide (CuInSe2) thin films electrochemically deposited were measured in the temperature range 30 to about 300 K. In general the films showed variable range hopping conduction mechanism, i.e., σ= (σ0 T−1/2) exp[ − (T0/T)1/4] with T0 between 4 × 102 and 6 × 103 K, at the lowest temperatures, and thermally activated conductivity, i.e., σ = σ0 exp( − Ea/kT) with Ea between 240 and 80 meV, over the temperature range close to the room temperature. The activation energy, Ea, decreased and the conductivity, σ, increased with the annealing treatment. The data of these annealed films are in agreement with the Meyer–Neldel rule. Grain boundary trapping models were considered in the analysis of the results.


Objective
To evaluate the efficacy and safety of higenamine hydrochloride(HG) stress echocardiography for diagnosis of coronary artery disease (CAD).

Methods
The study was designed as prospective, randomized, open-labled, positively controlled and crossover phase II multi-center clinical research. Ninety subjects who were suspected to have CAD were enrolled.HG dosage was titrated at 0.5, 1, 2, 4 μg·kg-1·min-1 every 3 min. Adenosine was injected 140 μg·kg-1·min-1 for 6 min with total dosage 0.8 mg/kg. Visual assessment of the left ventricle wall motionand 17-segment model were used for analysis of stress echocardiography. CAD was defined as identifying >50% diameter stenosis in at least one major coronary artery by coronary angiogram. All adverse reaction were recorded.

Results
For HG group, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 28.9%, 89.7%, 57.1%, 76.5% and 47.8%, respectively; for adenosine group, they were 26.7%, 94.9%, 58.3%, 85.7% and 47.1%, respectively. There was no significant difference between the two groups(P>0.05). The diagnostic sensitivities of HG and adenosine echocardiography for single vessel stenosis were 11.1% and 5.6%, respectively(P>0.05). Both HG and adenosine echocardiography have the same sensitivity with 37.5% for double vessel stenosis and 44.4% for triple vessel stenosis. Advers reaction rate was 84.4% in HG group and 92.2% in adenosine group(P>0.05).

Conclusions
HG stress echocardiography for CAD diagnosis has high specificity, good safety and low sensitivity, which are similar to adenosine echo.

Key words:
Echocardiography, stress; Coronary artery disease; Higenamine hydrochloride; Adenosine


A new ecdysteroside was isolated from the roots of Lygodium japonicum (Thunb.) Sw. The structure was identified as 2β,3β,14α,20R,22R-pentahydroxy-24R-methyl-5β-cholest-7-en-6-one-3-O-β-D-glucopyranoside by spectral and chemical methods.


In the present study, for six months, paired samples of blood were collected from 10 Thoroughbred race horses undergoing exercises of different intensities, namely: light (walking by step), moderate (trot) and intense (strong gallop). The samples obtained were subjected to analysis for the determination of serum urea, creatinine, potassium and sodium. The results showed that, with respect to creatinine, there was an increase of its concentration in the serum in the three types of exercise, and this increase was proportional to the intensity of the physical effort. An increasing of serum urea was seen only after moderate exercise. The serum concentration of the electrolyte sodium, in turn, remains unchanged before and after the exercises, regardless of their intensity. Finally, with respect to serum electrolyte potassium, no differences were observed between the values after the different types of work.


The mix program methods between VC and MATLAB is analyzed: MATLAB engine mode,MATLAB C/C++ function library transfer mode,MATLAB Compiler mode and Matcom tool with MATLAB COM Builder mode.We think the Matcom tool with MATLAB COM Builder mode is the trend of mix program methods.


A physical process model for inductive plasma dry etching is presented and applied to simulate vertical channel hole etching, a critical fabrication step in modern 3D NAND flash memory. A specialized advection algorithm is subsequently applied to simulate the selective epitaxial growth (SEG) of silicon on the bottom source line. The induced etching damage on the bottom silicon substrate, which is included in the etching model, is shown to heavily reduce the quality of the SEG. The removal of this damaged layer is shown to result in highly crystalline epitaxially grown silicon.


Abstract The constraints imposed by conservation of potential vorticity and hydrodynamic stability on the amplitude of Rossby waves are investigated.


Background: How health care providers perceive their capabilities affects their performance of their educational duties. Objectives: The present study was conducted on health and treatment staff to explain the experiences of health care providers regarding their perceived capabilities in delivering health education. Methods: Thepresentstudyisaqualitativestudywithaconventionalcontentanalysisapproach,whichwasconductedindifferent environments, including hospitals, doctors' offices, and health centers in Isfahan, Iran, using purposive sampling in 2017 - 2018. Thirty-twoparticipantswithanaverageexperienceof 8yearsof Thedatawereanalyzed using the MAXQDA software simultaneously with data collection. Results: Two themes emerged: (1) the ability to gain the audience's trust, with the two main categories of personal characteristics and communication skills, and (2) professional capabilities with the two main categories of attitude to the profession and professional conversance. Some subcategories of both themes acted as both augmenting and diminishing factors affecting the perceived capabilities of the health care providers. Conclusions: Anindividualhasabouthisownpersonalcharacteristics,communicationskills,andprofessionalcapabilities,which play central roles in the formation of their self-concepts. By enhancing these two factors via interventions based on the findings of such qualitative studies, the health care providers' self-concept related to health education can be improved.


This paper examines the price and volatility behaviour of two similar commodities (Brent Crude Oil and West Texas Intermediate) and attempts to identify the variables that affect their relative price differential. Price spreads and convenience yields are estimated in an effort to test a number of hypotheses relating to market segmentation, seasonality and maturity effect. Cash and futures price data covering the period 1991–1995 reveal that: convenience yields are significant and about 2.5% of cash prices on the average; convenience yields exhibit strong yearly and monthly seasonalities due to supply/demand imbalances; convenience yield is a negative function of the level of stocks and behaves like a call option; as maturity of futures contracts nears, their convenience yields get smaller, an indication that the maturity effect exists in futures prices, and crude oil price spreads are affected by convenience yields which act as surrogates for demand/supply conditions and market price behaviour.

http://wwwdocs.fce.unsw.edu.au/economics/Research/Time Series and Applied Macroeconomics Group/henker1.pdf


Whether woven, crocheted, bejewelled, feathered, dyed or painted, wearable art is meant to be animated by the human body. This work presents the work of 60 artists who have combined craft and art with the glamour of haute couture. 170 garments - each the product of intensive labour - are featured. The author established the first gallery devoted to clothing as an art form in 1973. The gallery is located in New York City.


We present a novel family of continuous linear time-frequency transforms adapted to a multitude of (nonlinear) frequency scales. Similar to classical time-frequency or time-scale representations, the representation coefficients are obtained as inner products with the elements of a continuously indexed family of time-frequency atoms. These atoms are obtained from a single prototype function, by means of modulation, translation and warping. By warping we refer to the process of nonlinear evaluation according to a bijective, increasing function, the warping function. Besides showing that the resulting integral transforms fulfill certain basic, but essential properties, such as continuity and invertibility, we will show that a large subclass of warping functions gives rise to families of generalized coorbit spaces, i.e. Banach spaces of functions whose representations possess a certain localization. Furthermore, we obtain sufficient conditions for subsampled warped time-frequency systems to form atomic decompositions and Banach frames. To this end, we extend results previously presented by Fornasier and Rauhut to a larger class of function systems via a simple, but crucial modification. The proposed method allows for great flexibility, but by choosing particular warping functions we also recover classical time-frequency representations, e.g. $F(t) = ct$ provides the short-time Fourier transform and $F(t)=\log_a(t)$ provides wavelet transforms. This is illustrated by a number of examples provided in the manuscript.


Introduction:the problem of monitoring the profitability of the main professional educational programs being implemented is becoming increasingly important in the context of the need to meet the criteria for the effectiveness of the activities of universities, the introduction of effective financial management in the universities and the modernization of the management system of educational programs. The profitability of the educational program is considered not only as a key indicator of the economic efficiency of the implementation of educational programs, but also as one of the significant factors in determining the prospects for the development of the university, which has a significant impact on the indicators of the university and characterizes the result achieved and the resources used.Materials and methods:in the article the issue of increasing the efficiency of the university activity under the conditions of the management of the basic professional educational programs is considered, the description of the information - analytical service for calculating the profitability of the implementation of the basic professional educational programs introduced in the Minin University as one of the key conditions for the effectiveness of the modernization of the management of educational programs is presented.Results of the research: the authors describe the methodology and the main stages of the project implementation for the creation and implementation of the electronic service "Calculation of the planned profitability of the implementation of the main professional educational programs", including the formation of the budget of income and expenditure of the main professional educational programs; the indicators obtained by the results of the introduction of the service are listed, the main effects from the introduction of the service are listed.Discussion and conclusions:the final part of the article examines the possibilities and limitations of the application of the experience of the Minin University in other higher education educational institutions, examines the problems encountered in the implementation of the project, lists the profitability of the implementation of educational programs, expected in the long term as a result of the implementation of the service.


Vector beams display varying polarisation over planes transversal to their direction of propagation. The variation of polarisation implies that the electric field cannot be expressed as a product of a spatial mode and its polarisation. This non-separability has been analysed for particular vector beams in terms of non--quantum entanglement between the spatial and the polarisation-degrees of freedom, and equivalently, with respect to the degree of polarisation of light. Here we demonstrate theoretically and experimentally that Mathieu-Gauss vector modes violate a Bell-like inequality known as the Clauser-Horn-Shimony-Holt-Bell (CHSH-Bell) inequality. This demonstration provides new insights into that fact that a more general class of vector modes with elliptical symmetry also violate Bell inequalities.


The utility model discloses a corrosion resistant steel pipe, which is provided with a thermoplastic powder coating (3), a thermosetting powder coating (2), a steel pipe layer (1), a thermosetting powder coating (2) and a thermoplastic powder coating (3). Compared with the prior art, a zinc-rich epoxy powder coating not only has corrosion resistant performance of epoxy resin, but also utilizes anodic protection effect of active metal to lead the coating to have excellent corrosion resistant protective capability; and a polyethylene coating adhered on the zinc-rich epoxy resin coating has enough compactness, can play the role in excellent shielding, and block even obstruct penetration of corrosion resistant medium.


Matrix metalloproteinases (MMPs) are potent modulators of the inflammatory response. In addition to the extracellular matrix, MMP substrates include growth factors, cytokines, chemokines and receptors. We recently reported that binding of PGE2 to the EP4 prostanoid receptor stimulates macrophage MMP‐9 expression, and COX‐2 expression via a positive feedback loop. To determine whether COX‐2 expression is modulated by extracellular MMPs, murine macrophages were incubated with active MMP‐1, 2, 3, 7 or 9. Both MMP‐1 and 3 stimulated macrophage COX‐2 expression in a dose‐dependent manner. In contrast, MMP‐2, 7 and 9 had no effect. Up‐regulation of COX‐2 expression required catalytically active MMP‐1 or 3, since expression was not stimulated by pro‐MMPs, and the induction of COX‐2 observed with active MMPs was blocked by specific MMP‐inhibitors. MMP‐induced COX‐2 was associated with an increase in PGE2 secretion and MMP‐9 expression, which were blocked by the selective COX‐2 inhibitor, celecoxib. It has been reported that MMP‐1 cleaves PAR‐1, and initiates PAR‐1‐dependent signaling. To determine whether the activation of PAR‐1 leads to induction of COX‐2 and MMP‐9, macrophages were incubated with SFFLR, a peptide corresponding to the PAR‐1 tethered ligand exposed by proteolysis. The specific PAR‐1 agonist stimulated COX‐2 and MMP‐9 expression; whereas, PAR‐2–4 peptide agonists failed to induce COX‐2 or MMP‐9. Together, these data suggest a regulatory mechanism whereby cleavage of the protease sensor PAR‐1 by either MMP‐1 or 3 stimulates macrophage MMP‐9 expression via a COX‐2‐dependent pathway.


is density, Dint is the average coefficient for the diffusion of internal energy, C Vtrans and Cint are the translational and the internal contributions to the molar heat capacity, zk is the number of collisions for relaxation of the kth internal mode, and ck is the heat capacity associated with that mode. In small rigid polyatomic molecules, the only collision numbers small enough to affect thermal conductivity signficantly


The invention discloses an electric generator wake-up judgment device, and the electric generator wake-up judgment device comprises a current detection element and a charge processing element. A first end of the current detection element is electrically connected with a power source conversion circuit, and a second end of the current detection element is electrically connected with an auxiliary micro power source; and the power source conversion circuit aims to be used in electric conversion and transmission between a power generation device and a load, and the power source conversion circuit is electrically connected with a main supply power source. A first end of the charging processing element is electrically connected with a third end of the current detection element, a second end of the charging processing element is electrically connected with the auxiliary micro power source, and a third end of the charging processing element is electrically connected with a microprocessor and is used to provide a wake-up signal to the microprocessor. Energy-saving and carbon-saving effects can be achieved.


of the year 1990 as the International Literacy Year.' The hope is that the total community of nations will rededicate itself to promoting literacy as a human right and an aid to development and that all will work toward achieving universal literacy by the year 2000. To achieve this end, an international symposium "Education for All" is planned for March 1990, sponsored jointly by United Nations Development Program (UNDP), the United Nations Educational, Scientific, and Cultural Organization (Unesco), the United Nations Children's Fund (Unicef), and the World Bank.2 During the decade just ended, researchers and scholars around the world have, of course, continued to make contributions that are both extensive and significant in defining policy issues, illuminating policy choices, and implementing program actions. These contributions, listed in the bibliography below, are the focus of this review essay.3 "Literacy for liberation," a theme given to the world by Paulo Freire in his book, Pedagogy of the Oppressed,4 still echoes in the literature of the 1980s.5 That literacy is a political act has become a cliche, but the political possibilities of literacy have been put in perspective. Freire and Donaldo Macedo, in their 1987 book, state: "We call for a view of literacy as a form of cultural politics. In our analysis, literacy becomes a meaningful construct to the degree that it is viewed as a set of practices that functions