In this chapter, two signed language technologies are introduced: signed language recognition and signed language synthesis/animation. The modality-specific challenges of these technologies are discussed, originating in the multichannel nature of signs and the lack of a standardized writing system. The state of research of each technology is outlined, demonstrating that the existing body of research is considerably smaller than that of the field of automatic spoken language processing. The chapter describes the combination of the two signed language technologies in real-world applications. Most importantly, it explores the potential application of each technology to second language (L2) signed language assessment. Finally, an example of an existing use case is given: the application of signed language recognition to a vocabulary test for adult L2 learners of Swiss German Sign Language.


The evaluation and application of all remote sensing, surface and subsurface methods of exploration are areas of concern with engineering geologists as well as geotechnical engineers. Also of interest is the application, evaluation, and correlation of all existing and proposed earth material classifications, surveys, and associated survey techniques. The paper provides a brief review of the dramatic evolvement of conventional methods of exploring and classifying materials as well as some of the promising new technologies that have been developed but have not yet been adopted as conventional; methods.


Objective: to know the preparation for hospital discharge carried out by the multi-professional health team for children with chronic conditions and their families. Method: qualitative, exploratory-descriptive research carried out between November 2018 and March 2019 through semi-structured interviews with ten professionals from the multidisciplinary health team at the Pediatric Clinic of a hospital in Paraíba. The interviews were submitted to Minayo's Thematic Analysis. Results: the preparation for hospital discharge is complex and suffers several influences from the dynamics of the service. We observed that it is difficult to include integrated actions in the preparation for discharge during the daily care of the multi-professional team. During this process, the importance of including the child in care is highlighted, emphasizing the need for self-perception about their current health situation, as well as the possibility of carrying out self-care, depending on their age, understanding, and risks when performing the procedure. Final considerations: there are several weaknesses in the implementation of the preparation for hospital discharge in the pediatric clinic, such as the lack of a protocol or standard that guides this process, carrying out disjointed and individualized interventions inherent to each professional training, hindering the family's effective learning process, compromising the safe return home.


OBJECTIVE
To determine the ability of mastic monotherapy to eradicate Helicobacter pylori infection from mice.

MATERIALS AND METHODS
The susceptibility of H. pylori SS1 to mastic was assessed by broth dilution determination of the MIC and MBC. Mice were inoculated intragastrically with either a suspension of H. pylori SS1 (n = 70) or brain-heart infusion broth alone (n = 10). Mice were given antimicrobial chemotherapy 4 weeks after infection and were administered the mouse equivalent of either 2 g of mastic twice daily for 7 days or a triple therapy regimen containing the mouse equivalent of 400 mg of metronidazole, 250 mg of clarithromycin and 20 mg of omeprazole twice daily for 7 days. Mice were killed either immediately or 1 month after the completion of treatment, and their stomachs cultured for H. pylori.

RESULTS
The mastic MIC and MBC of H. pylori SS1 were 7.80 and 31.25 mg/L, respectively. The triple therapy regimen eradicated infection from 19 of 20 SS1-infected mice. Mastic failed to eradicate infection from any of the 18 SS1-infected mice (P < 0.001) and there was no signifi- cant reduction in gastric bacterial load in mice treated with this regimen.

CONCLUSION
Despite reported beneficial effects in ulcer patients and the good in vitro activity of mastic against H. pylori, this compound is unable to eradicate H. pylori infection from mice.


Taking the coal bunker chamber of Tuzhu Mine as a case,the stability coefficient was calculated that of the surrounding rock with theory of loose ring and combined arch theory,the both results of calculations were higher than 1.1,the design parameters of bolting and grouting support coincidence the requirements of surrounding rock's stability and safety was proved. The stability of the surrounding rock was calculated and analyzed for the large cross section chamber with FLAC4.0. Three simulation schemes were set up,analyzed deformation of surrounding rock in three different schemes,the result indicated that the roadway is stabilization when using bolting and grouting support. At last,a plan of bolting and grouting support for the large cross section chamber was designed by project analogy method,the late site monitoring and measuring results showed that the results of the bolting and grouting support for the chamber was excellent and the combined support could keep a long team safety stability of the surrounding rock for the chamber. 4figs.,7refs.


Mental retardation is a common disorder, which imposes a large medical, psychological and social burden. It affects about 3% of the population, yet the pathogenesis is poorly understood. The prevalence and incidence of mentally retarded cases is alarming. Studies of the frequency and risk factors for cognitive disorder in children have been almost entirely restricted to developed countries, need of the hour is more conclusive research in this field to find out the risk factors associated with mental retardation . . However Diagnostic outcomes of these studies provided little information for the evaluation of patients. Accurate diagnosis of etiology has specific implication regarding treatment. Management of possible associated condition, prognosis, and estimation of recurrence risk and the design of prevention program .The information on possible risk factors and causes of mental retardation can be used for genetic counseling and pregnancy supervision. Monitoring of environmental risk factors could prevent our human health system from a serious life long disability and burden of the society could be reduced.


Introduction Anxiety and depression are common co-morbidities in COPD. Anxiety is associated with increased breathlessness, lower levels of self-efficacy, impaired health status, poorer treatment outcomes and reduced survival, increased risk of hospitalisation, longer in-patient stay, readmissions and unhealthy behaviours such as smoking and lack of exercise. The aim of this abstract is to present prevalence data, engagement and baseline patient characteristics from the largest RCT on CBT in COPD. Study design A multicentre RCT with follow up at 3, 6 and 12 months (ISCRCTN55206395). Outcome measures include mean HADS-A (anxiety) and HADS-D (depression) score,1 EuroQol -5D Questionnaire,2 COPD Clinical Assessment Tool3 and admission prevention at three, six and 12 months post intervention. Approach 1,518 patients were screened for symptoms of anxiety using the Hospital Anxiety and Depression Scale (HADS). Two thirds, 705 (59%) patients scored ≥8 for anxiety and were approached. Intervention Up to 6 CBT sessions provided by one of four respiratory nurses were offered. Self-help leaflets on anxiety and depression were provided as standard care. Usual care Self- help leaflets only. Results 42% of eligible patients consented to take part. Groups were well matched at baseline (Table 1) with no correlation between FEV1 and anxiety. A median of 4 CBT sessions (range 2–6) was delivered. Retention was high: 85% at 3 months and 72% at 6 months.Abstract M24 Table 1 Baseline characteristics CBT Group (n = 139) Control Group (n = 140) p-value (95% CI) Mean (SD) Mean (SD) Age 66 67 66.5 Gender Male 61 (44) 67 (48) 128 (46) Female 78 (56) 73 (52) 151 (54) Severity of COPD Mild 16 (11) 13 (9) 29 (10) Moderate 44 (32) 47 (34) 91 (33) Severe 50 (36) 49 (35) 99 (35) Very Severe 29 (21) 31 (22) 60 (22) Educational Level No educational qualifications 100 (75) 103 (77) 203 (73) HADS-Anxiety Score 12.3 (3.19) 12.0 (2.94) 0.47 (-0.456–0.988) HADS-Depression Score 9.4 (4.01) 9.0 (3.68) 0.34 (-0.470–1.347) CAT (Health Status) 28.2 (6.45) 28.7 (5.99) 0.52 (-1.944–0.990) EQ5D 0.41 (0.29) 0.41 (0.30) 0.95 (-0.07–0.07) Married or Co-habiting 68 (49) 63p (45) 132 (47) Current smoker 39 (28) 40 (29) 79 (28) Mean pack years 46 49 47 BMI 26 27 26.5 Conclusion The prevalence of anxiety and depression is high in patients with COPD and screening is therefore recommended. Affected patients were willing to engage in CBT in this large study. Results from 3, 6 and 12 months data will be will be available in November 2015 and will be reported. Results will include the cost effectiveness of CBT in COPD delivered by respiratory nurses. Funding NIHR fellowship. References 1 Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–370 2 EQ-5D. www.euroqol.org/about-eq5d/how-to-use-eq-5d.html. Accessed 11.4.2015 3 Jone PW, Harding G, Berry P, Wiklund I, Chen WH, Kline LN. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009;34(3):648–654


Abstract The flora and algal associations of Salomon's spring (Anterselva, Bolzano). Summer facies. – Salomon's spring is situated in Anterselva valley (Bolzano), a characteristic valley of a glacial escavation, having a typical profile formed like a « U » and a wide peat-bog on the bottom. The source springs at 1100 mts above the sea-level from a zone of waste-layer formed by fragments of metamorphic rocks (ortogneiss). Then it gives birth to a small pool from which the water flows very slowly forming a little stream. The spring has a plentiful algal flora rich of species (66, including the varieties too) belonging to the following classes: Cyanophyceae (12), Xanthophyceae (4), Bacillariophyceae (38), Euchlorophyceae (8), Ulothricophyceae (3), Zygophyceae (1). In the spring are described the following algal associations: –Diatometum hiemalis, that forms many brown-reddish little flocks on the borders and in the anfractures of the big stones that occupy the source; –Diatometum hiemalis subass. ceratoneiet...


1 2‐Azido photoaffinity analogues of adenosine 5′‐triphosphate (ATP), adenosine 5′‐diphosphate (ADP), adenosine 5′‐monophosphate (AMP), and adenosine have been synthesized and tested on guinea‐pig taenia coli. 2 2‐Azido‐ATP and 2‐azido‐ADP were approximately 20 times more potent than ATP as relaxants of taenia coli, and required prolonged washout times before recovery of the muscle. 3 2‐Azido‐AMP and 2‐azidoadenosine were 2 to 12 times more potent than ATP, but took much longer (up to 100 s) to reach maximal relaxation. This behaviour is different from that of AMP and adenosine which were much less potent than ATP. 4 l‐Enantiomers of adenosine and adenine nucleotides were also tested. l‐ATP and l‐ADP were 3 to 6 times less potent than ATP and ADP, and l‐AMP and l‐adenosine were inactive. 2‐Azido‐l‐ATP and 2‐azido‐l‐ADP were approximately 120 times less potent than 2‐Azido‐ATP and 6 times less potent than ATP as relaxants of taenia coli. 2‐Azido‐l‐AMP and 2‐azido‐l‐adenosine were almost inactive. 5 2‐Azido derivatives are photolysed by u.v. irradiation to reactive intermediates. 2‐Azido‐ATP and 2‐azidoadenosine might be suitable photoaffinity ligands for labelling putative P2 and PI purine receptors respectively. 2‐Azido‐l‐ATP and 2‐azido‐l‐adenosine could be useful controls for nonspecific labelling.


The existence and multiplicity of periodic solutions for a class of Lagrangian systems are obtained by the least action principle and a three-critical-point theorem.


The site-distributions of Fe in four B2-ordered NiAl-based alloys with Fe concentrations of 10%, 2%, and 0.5% have been determined by ALCHEMI (atom-location by channeling-enhanced microanalysis). Site-distributions have been extracted with standard errors between {approximately} 1.5% (10% Fe concentration) and {approximately} 6% (0.5% Fe concentration). The results show that Fe has no strong site-preference in NiAl and tends to reside on the site of the stoichiometrically deficient host element. An improved ALCHEMI analysis procedure is outlined. The analysis explicitly addresses the phenomenon of ionization delocalization, which previously complicated the determination of site-distributions in aluminide intermetallics, leading to inaccurate and oftentimes nonphysical results. The improved ALCHEMI analysis also addresses the presence of anti-site defects. The data acquisition conditions have been optimized to minimize the sources of statistical and systematic error. This optimized procedure should be suitable for all analyses of B2-ordered alloys. Several analyses at different channeling orientations show that the extracted site-occupancies are robust as long as the data are acquired at orientations that are remote from any major pole of the crystal.


In order to improve the industrial production efficiency of chitosan/starch film, reducing slurry rheology is an important measure. This paper explored that the temperature, chitosan starch ratio, plasticizing different components had a great impact on the rheology of the slurry. As the starch content and temperature increased, the rheology of the slurry first decreased and then increased. Finally, it was determined that when the slurry was transported at 60°C with chitosan: starch = 1:1.5 and only the chitosan was plasticized, the viscosity was the minimum. The viscosity of the slurry was related to the hydrogen bond formed by the slurry. The more hydrogen bonds, the greater the viscosity. Plasticizing chitosan destroyed the crystal structure and facilitated the formation of the network structure, which was conducive to the shear flow of the slurry.


Feel lonely? What about reading books? Book is one of the greatest friends to accompany while in your lonely time. When you have no friends and activities somewhere and sometimes, reading book can be a great choice. This is not only for spending the time, it will increase the knowledge. Of course the b=benefits to take will relate to what kind of book that you are reading. And now, we will concern you to try reading emergent information technologies and enabling policies for counter terrorism emergent information technologies and enabling policies for counter terrorism as one of the reading material to finish quickly.


Temperature data and summary statistics are presented for 256 sites in 9 metropolitan areas as part of the U.S. Geological Survey National Water-Quality Assessment Program studies of the effects of urbanization on stream ecosystems. The computer program (GRAN) that was developed to derive uniform data granularity and calculate temperature statistics (means, standard deviations, rates of change, degree days) is described, as are the methods used to estimate missing daily mean temperatures, degree days (annual and summer periods), and 7-day running averages of daily mean temperatures.


In this study, heat transfer characteristics in presence of a conducting body placed in the center of a unit square cavity is investigated by using the dual reciprocity boundary element method (DRBEM). The governing dimensionless equations in terms of stream function, temperature and vorticity are solved numerically, and the effect of the different thermal conductivities and sizes of the solid body on heat transfer is observed by isotherms and average Nusselt number. Thermal conductivity loses its effect on heat transfer in large Ra numbers, and the increase in the size of the body with a small conductivity and large Ra enhances heat transfer.


Axial stress corrosion cracks have been observed on the outer diameter of steam generator tubing in the upper bundle region in units at the Palo Verde Nuclear Generator Station (PVNGS). This paper describes a Monte-Carlo probabilistic model developed to provide an overall assessment of the risk of exceeding Regulatory Guide 1.121 structural limit requirements during plant operation. The chosen approach models crack initiation, crack growth, detection of cracks and subsequent removal from service. Cracking statistics from inspection results for Units 2 and 3 are used to predict the expected performance of Unit 1. A general approach to calculating the probability of structural limit exceedance as a function of run time is described for steam generator tubing experiencing stress corrosion cracking.


Abstract - This study presents the estimation method for the optimal capacity of BESS(Battery Energy Storage System) in order to reduce the electric charges of common consumer. The daily optimal charge and discharge plan of BESS which satisfies the given constraints is established using linear programming through the change of rated output/rated capacity of the time that shows the electric charges in the highest reduced rate has been selected. There will be a problem to compare only reduced rate because the bigger the rated capacity, the more reduced rate is increased. Therefore, rated output/rated capacity of the time when the reduced amount of electric charges for a year is higher than the investment cost of BESS was selected.Key Words : Electric cost savings rate, Optimal charge and discharge control, Battery energy storage system, Investment cost* Dept. of Electrical Engineering, Kyungpook National University, Korea.** Metropolitan Transit System Research Division, Korea Railroad Research Institute, Korea*** Dept. of Electrical Engineering, Koje College, Korea.† Corresponding Author : Dept. of Electrical Engineering, Kyungpook National University, Korea.E-mail : firstname.lastname@example.com : November 24, 2014; Accepted : January 26, 2015


Emerging mobile deep neural networks (DNNs) are prevalent in resource-limited devices because of their shrunken parameter size and reduced computation. However, when deploying mobile DNNs on conventional DNN accelerators, there will be a performance loss due to the reduction of processing element (PE) utilization. Conventional accelerators are generally designed base on a fixed pattern of data reuse, but the data reuse opportunities of different layers in mobile DNNs are diverse. To process mobile DNNs with high performance, we propose an architecture called MoNA (Mobile Neural Architecture), which includes a flexible dataflow and a reconfigurable computing core. The dataflow efficiently supports reconfigurable processing parallelism to maximize the PE utilization of mobile DNNs. The computing core is a 3D PE array, which supports the dataflow and avoids high bandwidth requirement.


With the rapid development of artificial intelligence technology and its deep integration with education, the use of intelligent means to analyze and study teaching behaviors has become a research hotspot. Teaching behavior can be divided into verbal behavior and non-verbal behavior, among which verbal behavior is the main way of classroom teacher-student interaction, accounting for about 80% of all teaching behaviors. At present, teaching researchers mainly use manual annotation to code and analyze teaching verbal behaviors, which has the problems of low efficiency and individual subjectivity, and it is difficult to collect a large amount of teaching verbal behavior data to analyze teaching patterns. This paper designs and implements a teaching verbal behavior analysis tool using teaching verbal behavior recognition algorithm. It provides the functions of speech transcription of teaching videos, automatic recognition and analysis of teaching verbal behaviors, and analysis of teaching verbal contents, with a view to providing assistance to teaching researchers in analyzing teaching verbal behaviors in instructional videos by using intelligent technology.


Minimizing power consumption is one of the primary technical challenges that today's IT organizations face. Laurie Minas and Brad Ellison highlight how power consumption has grown quickly, driven by the sheer number of servers deployed in datacenters. The operational expense for energy over a three year period of operation will soon equal the capital expense of hardware. Rack and blade servers concentrate heat in smaller spaces and demand sophisticated cooling systems, which themselves consume power. While servers dominate the power consumed by IT systems, storage systems and network switches draw power as well.


The MUC-3 task consists of generating a database of filled templates with respect to messages that belong to a general topical domain. In particular, for the current phase, the message collection belongs to the domain of terrorist activities. On the one hand, a decision as to the relevance of a message to a specified class of terrorist events should be made. If relevant, a predefined set of facts are to be extracted and placed as fills for appropriate slots of the template(s) created for this message. If not relevant, a template having a '*' as the fill in all but one slot, is created (see Appendix A for details). Some aspects of the MUC-3 task are amenable to be solved by techniques typically employed in information retrieval (IR). These techniques are especially designed to be applicable to any domain. In contrast, there are other aspects of the problem that may require a great deal of language understanding, thus needing natural language processing (NLP) techniques. For the most part, NLP techniques may be considered domain dependent.


Rebuttal Historical perspective seems in order. For approval in 1992 of the first disease-modifying drug in multiple sclerosis (MS),1 i.e. beta interferon, magnetic resonance imaging (MRI) experts testified to the Food and Drug Administration that "MRI was the disease". This was accepted uncritically, although there were some who noted several pieces of missing validation. Glaringly absent but a discerning measure was showing that treatment-related change in MRI correlated with meaningful change in disease. Some 20 years later, we are still waiting, thankfully not having held our breath. Early discussion about Prentice criteria highlighted that there remains no validation for the key outcome of long-term disability. Scientific questions remain; public debate has been limited. What there has been makes it clear that this is no ordinary scientific issue. The vigour with which reservations about MRI as an outcome are attacked starkly contrasts with the enthusiasm with which the flimsiest data which seem to support it are welcomed. There appear to be nonscientific forces at play. Honest critique of MRI as an outcome is usually met with the facial expression seen in restaurant customers on seeing an unordered item on their final tally, or if the passage of caviar is halted en route from spoon to an aficionado's mouth. The requirements for establishing MRI as an outcome measure are breathtakingly simple. Yet despite this, and now long past what would be reasonable expectation, we still see the problems that categorically plagued these analyses from the very beginning, for example, papers in which simple correlations between MRI and clinical outcomes were presented at the European Charcot Foundation this week. In most there is no acknowledgement that removal of a single data point might abolish p-values, bullishly claimed to be less than 0.01, and sensitivity analyses are all but unknown. It should go without saying that one needs to know the independent contribution of MRI to justify using this needlessly expensive measure – but it does not. Finding that MRI correlates with disability is simply the inevitable banal relationship of two things which accumulate with time, but what does it add? It has been hard to find any 'delta delta' analyses, where one of the deltas is change in a clinical outcome, having unambiguous meaning. The desire for a delta delta has led to the recent demonstration that MRI change and trial relapse rate correlate,2 failing to note that neither of these independently correlate with important long-term outcomes. In the long-term follow-up of the original beta interferon study, change in MRI during the trial did not correlate with disability at 16 years – explaining none of the variance in disability. Interestingly and importantly, baseline MRI did, but explaining only 12% of disability variance. Nevertheless, the correlations were only modest, and change in T2 burden, instrumental in drug approval, explained none of it.3 This result, apparently not unexpected by the MRI field, was met with an immediate attack on the primitive nature of the MRI measures in use at that time. However, critics, hoisted on their own petard, seem to have forgotten that it was precisely those MRI measures – that they now deem to be of no value – which led to approval, clinical decision making and trial outcome sine qua non, not to mention widespread adoption of therapy. "MRI is the disease" indeed! There can be no better illustration of the over-egging of MRI than examining citations to Brex et al.,4 almost none of which point out that half the patients were missing nor mentioned that the positive predictive value, claimed at 88%,was really 34% with an intention to scan analysis. It took people outside the MRI field, indeed outside the MS field, to highlight the deficiencies of MRI as an outcome. The Sylvia Lawry Centre in Munich made an enormous contribution by demonstrating that MRI measures varied more from centre to centre than they did between treatment and placebo, among other important contributions on the validity of clinical and other MRI measures. MRI measures should be a primary outcome endpoint in phase III randomized controlled trials in multiple sclerosis: No


This study aims to investigate the hypothesis proposing "Pair work and group work can develop students' academic performance". The researchers have adopted the quantitative and qualitative methods as well as the questionnaire (50) and interview (10) as the tools for collecting data relevant to the study. It is an attempt to bring to light the importance of pair work and group work to develop students' academic performance. The sample of this study is comprised of 70 people who shared the same background. The marks obtained from the questionnaire and interviews were compared. The results have revealed that pair work and group work play a great role in developing students' academic performance successfully. Accordingly, the results have shown that there are strong equivalences among the students who use pair work and group work. As a result, more space should be given to pair work and group work activities to develop students' academic performance in terms of interaction, transferring the meaning of their knowledge and strengthening the relationship among the students themselves.


Abstract : The first part of the report discusses a dynamic programming model in which all rewards obtained by the decision maker are assumed nonnegative. The decision maker's objective is to successively choose actions so as to maximize his expected reward earned over an infinite time span. It follows from known results that the decision maker's choice need only depend upon the outcome of a randomization that depends on the model only through the state of the model and the time when the choice is made. It is shown by counterexample that this is basically the smallest class of decision rules that need be considered. Conditions under which a stationary policy is optimal are also presented. The second part of the report discusses the same model under a new criteria, namely, the average cost incurred per unit time. An example is presented in which there does not exist an epsilon-optimal randomized stationary policy.


This study empirically explores the dynamic interactions between the European and Indonesian cocoa markets during the 2008 global financial crisis (GFC) and the 2011 European debt crisis (EDC) using a battery of time series approaches of cointegration and multivariate Granger causality. The study documented a long-run equilibrium between the European and Indonesian cocoa markets, implying a reciprocal relationship. However, an inefficient adjustment transmission in the Indonesian cocoa prices was recorded throughout the study. The US currency constantly influenced Indonesian cocoa prices, while cocoa markets were independent of fluctuations in world oil prices. Overall, the study recorded a different level of the speed of adjustment of short-run imbalances to long-run equilibrium in the domestic cocoa market across economic crises.


This study addresses from several perspectives the perception of young people regarding the problems of community cohesion. Social cohesion plays a decisive role in the ability to organize social groups, construction of harmonious social relations. The generation of the 21st century places a greater emphasis on social cohesion compared to the other generations. What barriers declare young people and how they see the future of a cohesive society in the Republic of Moldova, are the questions that find their interpretation. The empirical data were collected during the focus-groups with young people. The analysis of the synthesis of the answers has outlined the perceptions of young people regarding the problems of community cohesion. The epistemological interpretation of the research results suggests valuable conclusions regarding the correlation between young people and the construction of a cohesive society.


The grain sorghums have been used by man tor centuries. Their 1188 In this country has been Increasing tor ninety years. Today they are on. of the principal crope in the semiarid great plains ot the midcontinent area. The grain serves tor chicken and stock feed Instead of the corn used in the northern states. For many years yellow corn has been more popular than white owing to its greater Titamin-A content. The Interest In thts factor In whiteand colored-grain sorghums led to Its being Investlpted by Heller and Green (1926). Basing their conclusion on rat-growth methodl. they showed that yellow milo contains more Titamln A than the whitecoated varieties. Smith (1930) reported that many of the grain sorghuDll are inferior to yellow corn as a source ot vitamin A. Other arUcles indirectly point to that conclusion. In the 20 years Intervening since the work ot Heller and Green (1926), the development ot the chemical method of determining carotene (the precursor ot vitamin A) bas made it poulble to test large numbers of samples in much less time than by the biological method. During this period many new varieties have been introduced. Both of these tacts suggested the desirab11lty ot determining the carotene content ot all available samples.


This article describes a four-week service learning abroad program. Students from a U.S. university assist and teach in elementary school English classes for one month in Saxony-Anhalt, Germany while living with their German partner teachers. The program description and students' feedback illustrate that this program provides students with the opportunity to improve their cultural and language competence through immersion in the German culture away from their American peers. Students report feeling engaged in the lives of their host families and schools and gain new understandings of the German culture through the perspectives they encounter during their month of volunteering.


We prove that the space of possible final configurations for a parking problem is parameterized by the vertices of a regular Bruhat graph associated to a 231-avoiding permutation, and we show how this relates to parameterizing certain spaces of paths in the Johnson graph.


0 0 1 8 9 1 6 2 / 2 1 © 2 0 2 1 I E E E A considerable variety of open source projects find usage across the various computing appliances seen at use in our world today. By "open source," we refer to a software project that is freely distributed, and the code base is freely hosted.1 For such a project to exist and gain success over time, a number of people must necessarily contribute. Indeed, some projects of note have solitary contributors and owners. However, in our experience, we have seen that well-governed communities of contributors yield greater success over time. Furthermore, healthy projects rely upon standard principles that encourage conversation and community building. Open source projects come in all shapes and sizes, from the tiny tools maintained by a single developer to the multinational projects that span several continents, cultures, time zones, and businesses. As soon as more than one person is involved, there are a couple of questions.


A semiconductor die package is disclosed. In one embodiment, the semiconductor die package includes a substrate. The substrate comprises (i) a die attach region having a die attach surface, a lead frame structure comprising a lead having a lead face, and (ii) a molding material. The die attach surface and lead surface are exposed through the molding material. The semiconductor die is in the die attach region and is electrically connected to the leads. Semiconductor, Die, Package, Substrate, Lead, Lead Frame, Molding


With the development of Internet industry, equipment data is increasing. The traditional method is not suitable for processing large data. Aiming at inefficient problem of Apriori algorithm when mining very large database, an efficient parallel association rules mining algorithm (Advanced Pruning Parallel Apriori Algorithm) based on a cluster is presented. APPAA algorithm can enhance the mining efficiency, as well as the system's extension. Experimental results show that APPAA algorithm cuts down 85% mining time of Apriori, and it has good characteristics of parallel and expandable.so it is suitable for mining very large size database of fault diagnosis.


Autoantibodies against leucine glioma inactivated 1 (LGI1) are well recognised in elderly men without tumours who present with frequent, focal seizures and a hippocampalcentric pattern of cognitive impairment. These patients often progress over more than 3 months and show little evidence of inflammation on routine CSF testing, defying diagnostic criteria for autoimmune encephalitis. Furthermore, as the LGI1antibodies are of the 'noninflammatory' IgG4 subclass, several first principles collectively question a rationale for immunotherapy administration in this cohort. Yet, this form of autoantibodymediated central nervous system disease is clearly, and often exquisitely, sensitive to immunotherapies. We have witnessed patients whose seizure frequency plummets from 100/day to nil after just three doses of corticosteroids. Larger studies have confirmed timedependent immunotherapy sensitivity. For example, cessation of faciobrachial dystonic seizures (the most characteristic semiology in these patients) was observed in 75/85 (88%) patients 90 days after immunotherapy administration: an effect most marked in those who received early immunotherapies. However, the question of which immunotherapies to administer remains unanswered. The only randomised controlled trial in LGI1antibody encephalitis reported modest seizure and cognitive outcome improvements in those administered IVIG versus the placebo arm. Yet, ~75% of these LGI1antibody encephalitis patients progressed to receive corticosteroids, hinting that neuroimmunology's most faithful agent may be centre stage in optimising patient outcomes. Now, Rodriguez et al summarise data from 118 patients with LGI1antibody encephalitis (seen over 11 years), which strongly advocates for acute corticosteroid therapy. Their main finding at followup after a median of 1.4 months (range, 0–20) revealed that, by comparison to a group administered IVIG (n=21), the 49 patients treated with corticosteroids alone showed lower median absolute scores on the modified Rankin Scale (mRS; 1 vs 3; p=0.004), greater overall improvement in mRS (2 vs 0; p=0.008), more frequent seizure resolution (74% vs 21%; p≤0.001, including faciobrachial dystonic seizures (61% vs 7%; p=0.002)) and greater improvement in the Kokmen bedside cognitive assessment (5 vs 0 points; p=0.01). However, these striking group differences were not sustained at >24month followup. At this epoch, available in a subset of 54/118, seizures had almost universally resolved, Kokmen scores were no different between the two groups, and an mRS of 0–2 (often termed 'favourable') was reached in 87%. This apparently negative result may be explained by an insensitivity of the mRS to capture more subtle longer term differences, as previously well demonstrated in both this disease and in Nmethyl Daspartate receptorantibody encephalitis. And, despite its wider dynamic range, the Kokmen assessment may have shown no difference as only seven patients remained in the IVIGtreated cohort for this assessment. The authors appropriately acknowledge largely inevitable limitations of collecting data in uncommon conditions over many years: underpowered subset analyses, reduced potential to account for differing regimes of corticosteroid and IVIG administration and inconsistent followup durations. Nevertheless, in light of these collective findings, it now appears unethical to exclude the current standard of care— namely corticosteroids—from future clinical trials in LGI1antibody encephalitis. Such trials are likely to benefit from incorporating longitudinal seizure and cognitive outcomes, as these core clinical observations may offer different insights across the disease course. Yet, both may fail to capture sensitive features of key interest to patients, including fatigue, mood and employment status, and may not be easily extrapolated to other LGI1antibodyassociated syndromes, such as patients with relatively pure seizure disorders, neuropathic pain and peripheral nerve hyperexcitability. 7 In the absence of costly, highly coordinated, sequential, multicentre randomised controlled trials, carefully gathered clinical observations remain the mainstay of an evidence base in autoimmune encephalitis. To date, such studies have effectively informed our routine clinical practice in neuroimmunology, typically concur closely with expert clinical observations and continue to enhance our understanding of how to best manage our patients.


Revision of lithological logs for boreholes penetrating the volcanic center at Pahute Mesa, Nevada, has led to a thorough review of the volcanic stratigraphy and geologic structure. We have combined this review with a compilation of old and newly acquired gravity and seismic travel time data, producing a unified interpretation along a northwest to southeast profile. The analysis supports a new interpretation of the Silent Canyon caldera complex. The caldera is found to be more asymmetric than previously suggested, with the southeastern boundary formed by linear, high-angle normal faults and a more gently sloping northwestern boundary. The total thickness of volcanic units within the caldera complex does not appear to exceed 5 km. The shallow structure at Pahute Mesa could have a profound effect on the seismic response for regional and teleseismic signals from this nuclear test site. The Silent Canyon caldera complex is actually a set of nested calderas first filled by thick (>1 km) postcaldera lavas and subsequently buried by outflow sheets of the Timber Mountain caldera to the south. Thick, postcaldera lavas filled a half-graben structure formed west of the West Greeley fault, dropping the tops of the youngest caldera-forming units to depths in excess of 2 km. Therefore the western boundary of the caldera complex is poorly defined. East of the West Greeley fault, two overlapping calderas are defined, and stratigraphic data suggest the presence of even older calderas. The youngest caldera, the calc-alkaline Area 20 caldera, is well defined from drill hole data. The Area 20 caldera overlaps the 13.6 Ma peralkaline Grouse Canyon caldera, which is less well defined, but apparently collapsed in trap-door style along the Almendro fault. For both these calderas, collapse continued after the main caldera-forming eruption, concurrent with the accumulation of thick (>1 km) lavas within the peripheral collapse zones. The geophysical interpretation indicates that the major structural boundary of the caldera complex corresponds to the NNE trending Scrugham Peak and Almendro faults, which offset the pre-Tertiary contact more than 1 km but have less than 200 m offset in rocks of 11 Ma age. Drill hole data show that offsets along these faults increase systematically within older (up to 15 Ma) units, which are commonly rotated eastward in a style similar to units at the surface. Abrupt changes in the subsurface thickness of the caldera-forming units occur across the faults, indicating that these linear features served as caldera boundaries.


Suppose we're given a function f : {0, 1} n → {0, 1} n , specified by a black box. (Note that the outputs of f are n-bit strings, rather than single bits.) We're promised the following about f : there exists a nonzero secret string a ∈ {0, 1} n such that • For all inputs x ∈ {0, 1} n , f (x) = f (x ⊕ a). What these conditions mean is that f is a 2-to-1 function, and that any two inputs mapping to the same output differ in exactly those positions i for which a i = 1, where i is the i-th position in an n-bit string. For example, f (x) = 2 * ⌊x/2⌋. For any k, f (2k) = f (2k + 1). But for any i, j, if i and j are not like (2k, 2k + 1) pair, then f (i) = f (j). In this example, a is 1. Let x ⊕ y denote the bitwise mod 2 addition of x and y, and x · y denote the inner product of x and y, ∑ n i=1 x i y i mod 2. We now present Simon's quantum algorithm for finding a. The algorithm uses two registers , both with n qubits. The registers are initialized to the basis state |0 · · · 0 |0 · · · 0. We then perform the Hadamard transform H 2 n on the first register, producing the superposition 1 2 n/2 ∑ x∈{0,1} n |x |0 · · · 0. Then, we compute f (x) through the oracle C f and store the result in the second register, obtaining the state 1 2 n/2 ∑ x∈{0,1} n |x | f (x). The second register is not modified after this step. Thus we may invoke the principle of safe storage and assume that the second register is measured at this point. Let f (z) be the result of measuring of the second register. There are exactly two x such that f(x)=f(z), according to the definition of f. one is z and the other is z ⊕ a. The quantum state after measuring is 1 √ 2 |z + 1 √ 2 |z ⊕ a | f (z)


This guide is intended for designers and installers of hydronic heating systems interested in maximizing the overall system efficiency of condensing boilers when coupled with baseboard convectors. It is applicable to new and retrofit projects.


Simple Summary Although images are more effective than words at communicating important conservation ideas, different aspects of these images have been demonstrated to have positive and negative effects on viewers' views towards wildlife and towards the organisation that posted the image. The most prevalent and engaging characteristics of wildlife photographs posted to Instagram in 2020 and 2021 were assessed using a quantitative content analysis, with Australian organisations as a case study. The findings show that conservation organisations can confidently share and post photographs that promote positive attitudes towards wildlife and the conservation organisation, and that Instagram posts can feature and promote a wide range of currently underrepresented species. Abstract Wildlife populations are vanishing at alarmingly high rates. This issue is being addressed by organisations around the world and when utilizing social media sites like Instagram, images are potentially more powerful than words at conveying crucial conservation messages and garnering public support. However, different elements of these images have been shown to potentially have either positive or negative effects on viewers' attitudes and behaviours towards wildlife and towards the organisation posting the image. This study used a quantitative content analysis to assess the most common and engaging elements of wildlife images posted to Instagram in 2020 and 2021, using Australian conservation organisations as a case study. A total of 670 wildlife images from the Instagram accounts of 160 conservation organisation Instagram accounts were coded and analysed. Results highlight that the most common image elements used included natural backgrounds, mammals and birds, and no human presence. In addition, it was found that the taxon of the animal featured in a post and the presence of humans did not impact engagement levels. Our findings highlight the potential for Instagram posts to feature and promote a wide range of currently underrepresented species, and for conservation organisations to be able to confidently share and post images that promote positive perceptions of both the animal and the conservation organisation.


Objective To investigate the immunologic and cytogenetic features and the prognosis of M 2/t(8;21).Methods FAB morphological/cytochemical,flow cytometric indirect immunophenotying,cytogenetic analysis were performed in previously untreated AML M 2 of 95 patients.61 of 95 M 2 patients were treated with Daunomycine or Homoharringtonine and cytarabrine.Results (1) In 95 patients,M 2/t(8;21) were 53.7%(51/95),non t(8;21)M 2 were 46.3%(44/95).(2) CD 19 + rate were 49.0%(25/51) in M 2/t(8;21) and 6.8% (3/44)in non t(8;21) M 2,respectively(P0.001).(3)In M 2/t(8;21),CD 19 CD 34 expression were higher.(4) In M 2/t(8;21),CD 19 +/CD 34 + were 39.2% (20) and CD 19 -/CD 34 - were 7.8%;in non t(8;21),CD 19 +/CD 34 + were 4.5%(2) and CD 19 -/CD 34 - were 43.2% (19),P0.001.(5)CR rate:in CD 19 + and CD 34 - M 2,were 76.5%(13/17) and 47.7% (21/44),respectively (P0/05);in M 2/t(8;21) and non t(8;21) M 2,were 68.7%(22/32) and 41.4% (12/29) respectively (P0.05);in CD 19 +/t(8;21) and CD 19 - /non t(8;21) were 80.0%(12/15) and 40.7%(11/27),respectively (P0.05).Conclusion The t(8;21) is the characteristic chromosone abnormality of M 2.In M 2/t(8;21),CD 19 and CD 34 expression are high,CD 19 and the t(18;21) are significantly correlatd,combining CD 19 with CD 34 can predict t(8,21).Both CD 19 and t(18;21) are markers of good prognosis in M 2.


This paper uses group theory for enumeration of contacts between geometric elements necessary for kinematic registration or part referencing in robotics. The results are applied to type synthesis of tactile sensing mechanical fixtures. Kinematic registration is an important step in robot calibration and in data driven automation. Although the scope of the paper is limited to geometric contacts involving points, lines, planar surfaces, cylindrical surfaces, and spherical surfaces, the techniques developed are general and can be applied to other geometric features and non-tactile sensing elements used in robotic calibration and part referencing.


A beam chopper together with the temporal structure of x-rays emitted by a synchrotron storage ring can be utilized to generate x-ray bursts of variable length and time separation. A Si cube, cut for diffraction from the (220) planes, was mounted to a low-speed motor to produce a beam chopper based upon the Darwin width of the crystal. An x-ray pulse, consisting of an envelope of individual pulses characterizing the loading pattern of the storage ring, was transmitted. The width of the transmitted pulse and the time between pulses was varied by varying the rotation frequency of the Si cube. Pulses as short as approximately equal 75 ps or as long as approximately equal 4 microseconds were transmitted with pulse separation spanning from 4 ms to 167 ms.


The CDC and WHO have reported that Cardiovascular Diseases (CVD) have become the seventh leading cause of death in the US and the world. It is estimated that 17.5 million people die from CVD annually, representing over 30% of all deaths globally, and 1.6 million deaths are also directly caused by complications of diabetes mellitus (DM). This represents some 463 million people globally, and about 26.9 million people of all ages, 8.2% of the US population were diagnosed DM in 2018. DM is associated with known risk factors including obesity, hypertension, physical inactivity, elevated HbA1C, cigarette smoking, alcohol overconsumption, hyperlipidemia, and genetic factors. A considerable amount of progress has been made in the understanding the contributions of these known predisposing risk factors for CVD, but patients diagnosed with DM are affected disproportionately by CVD when compared with patients without DM. However, CVD is the most prevalent cause of morbidity and mortality in DM populations and the leading cause of early death among DM and disproportionately affects DM when compared with the non‐DM population. However, the traditional risk factors have not fully accounted for the in the DM‐CVD‐associated complications. DM and CVD are known to generally share the traditional risk factors, and do not fully explain the prevalence of DM as a risk factor for development of CVD and associated vessels disease in the DM population. Therefore, other novel risk factors such as insulin sensitivity (IS), endothelial dysfunction, vascular wall abnormalities, inflammation and homocysteine may also be important as novel CVD risk factors in DM. The study will highlight the importance of IS as a novel risk factor in the prevalence of DM as a risk factor for development of CVD and associated vessels disease in DM population. The goal of the study is to determine the prevalence and interrelation of novel risk factors for CVD among DM population, and to determine whether there is relationship between DM, CVD, and vessel disease among different patients. The results reveal that IS plays a factor in the prevalence of DM as a risk factor for development of CVD. Insulin resistance (IR) can work as a catalyst in causing several metabolic alterations to induce the development of CVD. For instance, chronic hyperglycemia from imbalanced glucose metabolism due to IR may induce oxidative stress causing an inflammatory response that leads to cellular damage. In conclusion: Understanding the importance of IS in the pathophysiology of DM was found to be a key factor and major influencing factor in CVD‐associated complications during potential therapy to improve CVD prevalence and outcome and contributes to development of CVD by (1) IR works as a metabolic pathophysiologic catalyst; (2) IR creates hyperglycemic conditions which induces oxidative stress causing an inflammatory response that leads to cell damage and atheroma plaque formation. causing several metabolic alterations to induce the development of CVD. Adequate glycemic control via pharmacotherapy and lifestyle modification remains the primary strategies in reducing risk factors for CVD in DM.


As with other forms of biotechnology, assisted reproductive technologies (ARTs) have become a normative part of women's reproductive health care with critical impact on women's subjectivities. Yet as these technologies have proliferated, feminist and cultural theories have taken up the challenges of theorizing the subjectivities produced through these interventions, while psychoanalysis has remained relatively mute, and certainly uncritical. This article uses interview research conducted by a psychoanalyst with women and men who went through some form of ART. Of particular interest is the creation of liminal and asynchronous temporalities that situate people in spaces marked by a particular futurity of being "not yet pregnant." Within this uncertainty, temporal forms of affect regulation emerge for self-preservation, especially for survivors of sexual trauma, for whom ART interventions and a "confusion of tongues" surrounding them can be profoundly retraumatizing.


RESPECT THE INVENTION HEAT TREATMENT OF FIBER MATERIALS THERMAL INSULATION, PARTICULARLY FOR RESINS FOR THEIR THERMOSETTING BINDER. THE MATERIAL IS SUBJECT TO A RADIATION FIELD HYPERFREQUENTIEL, WATER CONTENT OF SAID MATERIAL AND INTENSITY OF RADIATION FIELD IS aDJUSTED TO APPROPRIATE LEVELS AND HAS A HOT GAS FLOW. THAT METHOD OF DUCT TREATMENT FOR A VERY FAVORABLE ENERGY EFFICIENCY, AND A VERY GOOD hOMOGENEITY OF FEATURES PRODUCT. THIS APPLIES PARTICULARLY VERY EFFECTIVE WAY TO SHELL INSULATION BASED MINERAL FIBER FELT.


Metabolic syndrome, originally described in 1988 as "syndrome X" by Reaven et al. ([1][1]), has evolved in our collective thinking from a vague association of common chronic disease states to a formally defined cluster of clinical traits with adverse impact on cardiovascular risk ([2][2]). The


In this paper we describe new observations on the production of voids and void-structures in heavily irradiated NaCl under electron irradiation. Until now there is no information about voids in NaCl in the literature. In many irradiated samples voids with sizes between 0.05 and 0.7 mu m have been observed. Very large voids with diameters 1.2 to 5 mu m have been found in heavily irradiated natural rocksalt. The size, shape and distribution of the voids depend strongly on the irradiation dose, the irradiation temperature and the presence of impurities. The small, randomly distributed voids, observed in the earlier stages of the irradiation, transform with increasing irradiation doses into a more or less regular void lattice. The lattice of the voids is similar to the one of NaCl with the same axes. The ratio: void spacing/mean a void diameter is in the range 2 to 7 has been found. We did not observe saturation of the size of the voids up to irradiation doses of 150 Grad. The density of the void lattice did not saturate either.


The utility model discloses a folding frame for pushchairs, characterized in that: the utility model comprises a support frame provided with a wheel set; a socket seat, wherein a front feet tube and a rear feet tube are articulated under the socket seat; a front folding pole and a rear folding pole are articulated between the front feet tube and the rear feet tube, and the front folding pole and the rear folding pole are inter-articulated; a locking mechanism that is positioned between the front folding pole and the rear folding pole and can control the pivoting and fixing of the front folding pole and the rear folding pole; an upper support frame that is provided on the socket seat, and is connected with and supports a seat frame; a handle tube for pushing of the pushchair, which is connected at two sides of the upper support frame; and a release mechanism that is used to control the locking mechanism, which is positioned on the handle tube. The utility model has a firm, stable and safe structure, and can effectively prevent the frame of the pushchair from being folded unexpectedly.


In this work we have applied the admittance spectroscopy technique to characterize the DX centers in AlxGa1−xAs alloys doped with silicon. Our experimental results reveal the existence of two DX centers related to silicon in AlxGa1−xAs alloys, named DX‐I and DX‐II centers, with thermal activation energies of 0.370 and 0.415 eV, respectively. These values are lower than those obtained by other authors using capacitance techniques. To explain this disagreement it should be noticed that capacitance techniques can be affected by the nonexponential behavior of the thermal emission transients of the DX centers in AlxGa1−xAs alloys.


The idea that land plants are derived from multicellular aquatic green algae is almost as old as the science of botany. For a century or more, ever since botanists have believed in evolution, beginning students have been taught the succession Thallophyta, Bryophyta, Pteridophyta, Spermatophyta, however much the names of these formerly recognized major divisions may have been altered. Because of their photosynthetic pigments, cellulose walls, starch, and other features, the "Thallophyta" ancestral to archegoniates have been supposed to be green algae, of which nearly all of the multicellular forms are aquatic. Very recently, however, good reasons have arisen for questioning this dogma. The algae that have been believed to be so near to the ancestors of land plants are, very probably, on a sideline that never led to terrestrial forms (Pickett-Heaps 1975b; Stewart and Mattox 1975). Moreover, the line that actually led to the archegoniates and seed plants may have started with unicellular forms that inhabited aquatic interstices in moist soil, and so from the geographic and ecological point of view were terrestrial. Their derivatives that led to archegoniates may have acquired their -multicellular plant bodies in association with a terrestrial rather than an aquatic life. The formal history of green plant phylogeny begins with the demonstration by Hofmeister in 1851 that bryophytes and pteridophytes, as the archegoniates were then called, pass through an alternation of two generations; of these, the gametophyte is more closely tied to a moist environment, while the sporophyte, with its firm cell walls, rigid structure, and light, air borne spores, is better adapted to dry land. From these facts, F. 0. Bower, in a series of papers published at the beginning of the century, followed by a detailed and exhaustive book (Bower 1908), drew the logical conclusion that the invasion of the land coincided with and depended upon the evolution of the diploid sporophyte from the haploid gametophyte. His hypothesis included a very precise speculation about the origin of the sporophyte itself. He was fully aware of two concepts developed by Celakovsky, who in 1874 observed that in some plants, such as the brown alga Dictyota and the red alga Polysiphonia, the sporophyte generation follows the same developmental sequence as the gametophyte, and the two generations are almost indistinguishable from each other except for the kinds of reproductive cells


A method for checking the operation of an actuator (1), with a control valve (4) via an actuator (2) acting by means of a on the control valve (2) positioning element (3) is adjustable, a position sensor (10), which is position of the actuating element (3) is detected, and an electro-pneumatic positioner (8) which generates in dependence on the actual position and a desired position a pneumatic manipulated variable to the actuator (2) via an activated magnetic valve (7) is supplied, which is supplied to its activation by a process control device (12) with a supply voltage (Vs) and can be deactivated in an emergency for venting of the actuator (2) by switching off the supply voltage (Vs) - wherein the control element (3) is moved for carrying out a partial stroke test for a short time over a part of its actuating path, while the adjusting movement is detected and - wherein for carrying out a magnetic valve test, the magnetic valve (7) is briefly deactivated so that the control element (3) moves only over a part of its actuating path, thereby...


Technology is increasingly infiltrating all aspects of our lives and the rapid uptake of devices that live near, on or in our bodies are facilitating radical new ways of working, relating and socialising. This distribution of technology into the very fabric of our everyday life creates new possibilities, but also raises questions regarding our future relationship with data and the quantified self.

By embedding technology into the fabric of our clothes and accessories, it becomes 'wearable'. Such 'wearables' enable the acquisition of and the connection to vast amounts of data about people and environments in order to provide life-augmenting levels of interactivity. Wearable sensors for example, offer the potential for significant benefits in the future management of our wellbeing. Fitness trackers such as 'Fitbit' and 'Garmen' provide wearers with the ability to monitor their personal fitness indicators while other wearables provide healthcare professionals with information that improves diagnosis.

While the rapid uptake of wearables may offer unique and innovative opportunities, there are also concerns surrounding the high levels of data sharing that come as a consequence of these technologies. As more 'smart' devices connect to the Internet, and as technology becomes increasingly available (e.g. via Wi-Fi, Bluetooth), more products, artefacts and things are becoming interconnected. This digital connection of devices is called The 'Internet of Things' (IoT). IoT is spreading rapidly, with many traditionally non-online devices becoming increasingly connected; products such as mobile phones, fridges, pedometers, coffee machines, video cameras, cars and clothing. The IoT is growing at a rapid rate with estimates indicating that by 2020 there will be over 25 billion connected things globally.

As the number of devices connected to the Internet increases, so too does the amount of data collected and type of information that is stored and potentially shared. The ability to collect massive amounts of data - known as 'big data' - can be used to better understand and predict behaviours across all areas of research from societal and economic to environmental and biological. With this kind of information at our disposal, we have a more powerful lens with which to perceive the world, and the resulting insights can be used to design more appropriate products, services and systems. It can however, also be used as a method of surveillance, suppression and coercion by governments or large organisations. This is becoming particularly apparent in advertising that targets audiences based on the individual preferences revealed by the data collected from social media and online devices such as GPS systems or pedometers. This type of technology also provides fertile ground for public debates around future fashion, identity and broader social issues such as culture, politics and the environment.

The potential implications of these type of technological interactions via wearables, through and with the IoT, have never been more real or more accessible. But, as highlighted, this interconnectedness also brings with it complex technical, ethical and moral challenges. Data security and the protection of privacy and personal information will become ever more present in current and future ethical and moral debates of the 21st century. This type of technology is also a stepping-stone to a future that includes implantable technology, biotechnologies, interspecies communication and augmented humans (cyborgs). Technologies that live symbiotically and perpetually in our bodies, the built environment and the natural environment are no longer the stuff of science fiction; it is in fact a reality. So, where next?...

The works exhibited in Wear Next_ provide a snapshot into the broad spectrum of wearables in design and in development internationally. This exhibition has been curated to serve as a platform for enhanced broader debate around future technology, our mediated future-selves and the evolution of human interactions.

As you explore the exhibition, may we ask that you pause and think to yourself, what might we... Wear Next_?

WEARNEXT ONLINE LISTINGS AND MEDIA COVERAGE:

http://indulgemagazine.net/wear-next/

http://www.weekendnotes.com/wear-next-exhibition-gallery-artisan/

http://concreteplayground.com/brisbane/event/wear-next_/

http://www.nationalcraftinitiative.com.au/news_and_events/event/48/wear-next

http://bneart.com/whats-on/wear-next_/

http://creativelysould.tumblr.com/post/124899079611/creative-weekend-art-edition

http://www.abc.net.au/radionational/programs/breakfast/smartly-dressed-the-future-of-wearable-technology/6744374

http://couriermail.newspaperdirect.com/epaper/viewer.aspx

RADIO COVERAGE

http://www.abc.net.au/radionational/programs/breakfast/wear-next-exhibition-whats-next-for-wearable-technology/6745986

TELEVISION COVERAGE

http://www.abc.net.au/radionational/programs/breakfast/wear-next-exhibition-whats-next-for-wearable-technology/6745986

https://au.news.yahoo.com/video/watch/29439742/how-you-could-soon-be-wearing-smart-clothes/#page1


Objective
To investigate the epidemiology of chronic kidney disease (CKD) in patients with hypertension and diabetes mellitus in Kunming urban area.

Methods
A multistage cluster randomized sampling method was used to collect 400 randomly selected patients (community managed hypertension and diabetes mellitus) in community service centers in the 4 main urban districts of Kunming, Yunnan province. The subjects were screened for CKD by questionnaires, physical examinations, and microalbuminuria tests.

Results
A total of 343 people were surveyed. The prevalence of albuminuria, proteinuria by routine urinalysis, decreased glomerular filtration rate, and CKD prevalence were respectively 37.3%, 12.2%, 5.0% and 39.1%.A total of 134 patients with CKD (134/343) were screened. Logistic regression analysis showed male (OR=2.312, 95%CI 1.325-4.037, P=0.003), hyperuricemia (OR=1.751, 95% CI 1.109-2.765, P=0.016) and obesity (OR=2.150, 95% CI 1.115-4.146, P=0.022) were related to CKD.

Conclusions
The prevalences of CKD and albuminuria are 39.1% and 37.3% in patients with chronic diseases (hypertension and diabetes) in the main urban community of Kunming, Yunnan. Hyperuricemia, male and obesity are independent risk factors for CKD.

Key words:
Renal insufficiency, chronic; Community medicine; Epidemiology; Albuminuria; Hypertension; Diabetes mellitus


To design reliable structures, extreme pressures and peak factors are required. In many applications of Wind Engineering, their statistical analysis has to be performed by considering their non-Gaussian nature. In particular, in the shear layers and where local vortices are formed, it is commonly observed that measured pressures might exhibit two or more significant components, which can be modeled with mixture models. Mixing two components with unequal weight may result in much larger non-Gaussianities (even if the two components are Gaussian) than a single (non-Gaussian) component. For this reason and some others, it is important to split a mixed flow into its underlying components [1]. In this paper, we propose a novel de-mixing method. Unlike existing approaches which are based on a nonlinear least-square fitting of the probability density function (PDF), the proposed method is supported by the different timescales of the mixed phenomena. The method is briefly described, and two examples of application are given.


This is a position paper* which advocates textile and apparel trade with fewer restrictions. The paper evaluates the advantages and disadvantages of protectionist legislation for the textile sector; also considered are the position of the consumer, and the economy more broadly. Proposed U.S. textile legislation is evaluated in the context of the current political climate, both nationally and internationally. When all factors are considered, the casts of protectionism may exceed the benefits, perhaps even for the industry.


A mathematical correlation for prediction of flammable gas cloud size in a typical offshore module is proposed. Real conditions regarding the ventilation and the process plant operation were considered. A dispersion study of a natural gas release was performed using CFD. A Response Surface model was developed based on the numerical results and Response Surface Methodology. The developed model has proved to be effective once it was able to predict flammable gas volumes. Good agreement with CFD results was observed.


Rubber, particularly carbon black-filled rubber used in tires, plays a critical role in a world of mobility. Tires are exposed to various influences, including temperature fluctuations, dynamic mechanical loads, and exposure to solar-origin UV radiation, which can affect their durability. To investigate the effects of UV radiation on tire aging, this study aimed to identify spectral absorption ranges in specifically aged tire samples providing information about their aging condition. The study utilized samples of different rubber compounds and exposed them to UV radiation for varying durations from 48 h up to 1000 h. ATR (attenuated total reflection) spectroscopy was used to analyze the aged samples and evaluate changes in their chemical structure. The results showed consistent aging behavior across all samples, with a decrease in the intensity of the double peak at approximately 2900 cm-1, corresponding to the C-H bond. Another aging-relevant range from 1500 cm-1 to 1450 cm-1, characteristic of C-H groups as well, exhibited a declining absorption trend with UV aging. The impacts on the absorption spectrum resulting from the different rubber mixtures' compositions led to a reduction in the intensity of characteristic peaks. For evaluating the aging state of used tires, the CH related peaks can be utilized.


Source Citation Rucker D, Padwal R, Li SK, Curioni C, Lau DC. Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ. 2007;335:1194-9. 18006966


Rheumatoid Arthritis (RA) is a chronic inflammatory disease of the joints. The hallmark of RA is persisting inflammation in diarthrodial joints with infiltration of leukocytes, thickening of the synovial lining layer and synovial pannus formation. The therapeutic aim for RA patients is to alleviate the symptoms, slow the disease progression and optimise the quality of life. In recent years the measures to achieve this goal have improved with the development of new drugs. Despite recent advances in therapies for RA, there is still no drug available that induces remission in all patients. Thus, there is still a need to screen and develop new anti-rheumatic treatments. Because of this we investigated the effects of treatment with compounds which were extracted from three different sources in collagen-induced arthritis (CIA) in Dark Agouti (DA) rats. The constituent of the first compound is dominated by flavonoids together with other extractable compounds derived from Artocarpus leaves. The second compound is Glucurononxyclomannan (GXM) isolated from culture filtrates of Cryptoccocus neoformans. GXM is a polyssacharide with an unbranched mannose backbone. The third compound, code named Rob 803, is 9-chloro-2,3 dimethyl-6-(N,N-dimetylamino-2-oxoethyl)-6H-indolo [2,3-b] quinoxaline, an analogue of a previously reported substance, B220. B220 was originally investigated as an anti-viral drug. Results: 1. Treatment of rats with the Artocarpus extract decreased arthritis incidence and severity and delayed disease onset. In vitro, the Artocarpus extract acted as a T cell modulator, inhibiting mitogen-induced T cell proliferation and inducing apoptosis of activated cells. A new flavonoid glucoside named artonkin-4'-βD-O-glucoside with an average molecular mass of 514.49 Da was isolated together with three other previously known flavonoid molecules. All four compounds were found to have anti-inflammatory effects. These effects correlated well with the inhibition of mitogen-induced T cell proliferation. Furthermore, the compounds inhibited TNF and IFNγ production of ConA stimulated T cells in a concentration-dependent manner. 2. Treatment of CIA with GXM at a dose of 50 mg/kg suppressed disease development both prophylactically and therapeutically. The effect of GXM was associated with a significant decrease of the titers of anti-CII antibodies. GXM therapy diminished MMP-2 activity but had no effect on apoptosis. 3. The anti-arthritic effect of the synthetic compound Rob803 was evaluated in the CIA model. Daily subcutaneous treatment with 40mg/kg/day of Rob803 significantly suppressed arthritis severity and delayed the onset of clinical arthritis. In vitro analysis of the anti-inflammatory effects of Rob803 revealed that Rob803 suppressed NO2 production. Interestingly, T cell proliferation was suppressed at a 1000-fold lower concentration than was NO production. Thus we report that early subcutaneous administration of the synthetic substance Rob803 has antirheumatic effects which are likely to be mediated via T cell suppression. Conclusion: All of the investigated new compounds have anti-arthritic properties when tested in CIA. They have anti-T cell proliferative features which can be of benefit in modulating arthritis pathogenesis. Some of the investigated compounds also have cytokine-inhibiting properties. All compounds have low toxicity. They have the potential to be further investigated in experimental as well as clinical trials of RA and in other inflammatory diseases. LIST OF PUBLICATIONS


We prove that regular 2-SAT with signs of the form | i and J, i, where the underlying truth value set forms a lattice, is solvable in quadratic time in the size of the input, and in the case where the lattice is fixed, in linear time in the size of the formula. Moreover, we show that the satisfiability problem for 2-CNF formulas in multi-valued logics based on arbitrary De Morgan algebras may be done in time linear in the size of a formula and quadratic in the size of the underlying algebra. All algorithms we develop find satisfying valuations if they exist.


In this work, a hybrid filter based on acoustic wave resonators is shown. The filter uses lumped elements to increase the effective electromechanical coupling factor of the acoustic wave resonators. The simulation results show that a hybrid topology could be used in 5G frequency bands that require a fractional bandwidth over 25%.


Most of the existing clustering algorithms for networks are unsupervised, which cannot help improve the clustering quality by utilizing a small number of prior knowledge. We propose a semisupervised clustering algorithm for networks based on fast affinity propagation (SCAN-FAP), which is essentially a kind of similarity metric learning method. Firstly, we define a new constraint similarity measure integrating the structural information and the pairwise constraints, which reflects the effective similarities between nodes in networks. Then, taking the constraint similarities as input, we propose a fast affinity propagation algorithm which keeps the advantages of the original affinity propagation algorithm while increasing the time efficiency by passing only the messages between certain nodes. Finally, by extensive experimental studies, we demonstrate that the proposed algorithm can take fully advantage of the prior knowledge and improve the clustering quality significantly. Furthermore, our algorithm has a superior performance to some of the state-of-art approaches.


Human negativity toward arthropods has been well documented but the factors that contribute to this negativity have been elusive. This study explored knowledge of arthropod carnivory and herbivory as possible casual factors that contribute to the negative tendencies preservice elementary teachers have toward most arthropods. Specifically, this study investigated the effect knowledge of arthropod carnivory and herbivory had on United States kindergarten through sixth grade preservice elementary teacher attitude toward that arthropod and belief concerning the likelihood of incorporating information about that specific arthropod into their future science classroom. A cluster randomized design with a control group was used for the study. The treatment group consisted of 147 preservice elementary teachers and the control group consisted of 151. Unique to this study is the finding that arthropod carnivory and herbivory are causal factors that strongly affect preservice elementary teacher attitude and belief toward arthropods. When the participants of the study were made aware that an arthropod they thought was a herbivore was actually a carnivore, their attitude and likelihood of incorporation significantly declined. When the participants of the study were made aware that an arthropod they thought was a carnivore was actually a herbivore, their attitude and likelihood of incorporation significantly increased. Implications and future research are discussed.


I will criticize a proposed justification of punishment. Some theorists think that the challenge of justifying punishment can be met by emphasizing its expressive character, i.e., its capacity to express criticism. One such justification, or type of justification – call it Expressive Retributivism or ER – combines retributivist and expressivist considerations. These justifications are retributive since they do not appeal to consequences, aiming instead to show that punishment is an ''intrinsically'' appropriate response to offenses, i.e., something offenders deserve. The expressivist element in these justifications, however, is meant to correct for the widely criticized obscurity of traditional retributivism. Retributive arguments often rely on controversial intuitions of questionable reliability and justificatory power. While these intuitions are powerful, many worry that the justificatory challenge cannot be met merely by


The inheritance of ABO blood type group is actually determined by triple allelic gene, A, B and O. Transmission of blood group AB by a single chromosome, instead of by two separate chromosomes, was reported and called cis AB. The anesthesiologists, who meet many cases of the transfusions, may anesthetize cis AB patients for surgery. Recently the authors have experienced one case of patient with cis AB blood type undergoing emergency craniotomy and removal of hematoma. We transfused the patient with Rh+O packed red blood cell without any significant transfusion reactions. (Korean J Anesthesiol 1999; 36: 563∼567)


At present,the digital reference service is widely applied in libraries.People attach much importance to the legal problems involved in the digital reference service.This paper discusses on the copyright problem involved in the digital reference service,the legal problems in the cooperation among libraries,and the protection of users' privacy,etc.,and puts forward some corresponding suggestions and countermeasures.


Provides students and practitioners with a summary of useful ideas and frameworks to enhance effectiveness in problem solving. This clearly laid-out text aids students in courses and executive programs who may have difficulty organising their ideas and information into coherent analyses of the problems and assignments they are working on. Regular use of the ideas, frameworks, tools and techniques presented in this book will make individuals and teams less susceptible to these limitations and biases as they tackle managerial problems.


Women in Africa and its diaspora have always produced knowledge across time and in various contexts, both as organic intellectuals and as those formally tied to knowledge industries such as the academy. Codifying a black women's intellectual history field, though, has ramifications for all disciplines: an overrepresentation of black women as "doers" without sufficient consideration of their history of ideas leaves allied fields insufficiently conceived and entire disciplines underdeveloped. Toward an Intellectual History of Black Women includes fifteen scholarly essays assembled to situate black women's experiences within a history of ideas generally. The editors foreground the generative influence of grand historical experiences such as slavery, colonization, and segregation. When black women have produced knowledge, what has been the content and the process? According to the editors, the result is an "intellectual history 'blackwoman-style,' an approach that understands ideas as necessarily produced in dialogue with lived experience and always inflected by the social facts of race, class, and gender" (p. 4). An avowed turn toward black women's intellectual history is at once old and new. In discrete places, scholars have long examined the history of black women's ideas, especially in literary criticism, and have noted the intellectual and political value of doing so.1 The editors here make no false or exaggerated


High Voltage DC systems are gaining widespread attention due to the advances in power electronic devices and converters. MMCs are very popular nowadays in this type of application. This paper first revisits the dynamic equations of the circulating current of a MMC to incorporate a disturbance term. Based on the modified equations, a disturbance rejection controller is proposed to eliminate the double fundamental ac part of this current. In a larger scale, a platform for the offline and real time simulation of MMC based HVDC is designed. Hardware-in-the Loop (HIL) simulations are then conducted to validate the circulating current controller and a case study on the Lower Churchill project is illustrated to show the feasibility of an actual MMC implementation.


Citation for published version (APA): Hammarlin, M-M., & Jönsson, L-E. (2021). Gossip as Journalism and Journalism as Gossip: A Cultural History Investigation of Two Royal Sex Scandals in Sweden 1890 and 2010. In A. Haller, H. Michael, & L. Seeber (Eds.), Sacandalogy 3: Scandals in New Media (pp. 61–80). (Political Science and International Studies). Springer. https://doi.org/10.1007/978-3-030-85013-5_5


Abstract : The Reliability Improvement Warranty has grown in acceptance as a plausible contractual method of improving field reliability and reducing maintenance costs of military hardware. The acceptance of RIWs has not been universal, however, with many factions doubting the actual success and value of the RIW concept. Much confusion and uncertainty clouds warranty experimentation and more orderly progress is necessary to determine the feasibility of future RIW expansion. This study examines the current issues of RIW development and the controversy that has arisen over its use. The aspects of expanding Reliability Improvement Warranties to shipboard equipments is also explored. Interviews with personnel in the reliability field, case studies and other reports are used to collect information on the facts and issues influencing the controversy. An attempt is made to distill these facts and issues and to place them into an orderly and understandable perspective.


This paper presents a methodology for business process modelling. The methodology recognizes and separates logical and physical models of business processes. The Logical Model represents collection of fundamental and atomic business functions (activities) mostly independent of organisational and technological constraints. The Physical Model, in the context of the given organisational and technological environment, defines a business process as a thread of specific implementations of specified fundamental activities. Structured System Analysis is used as a tool for logical business process modelling and Activity Diagrams as a tool for physical business process modelling.


The antifungal substances effective against "akagusare"-infected Porphyra sp. were isolated by gas liquid chromatography equipped with a preparative apparatus. After being methylated, those substances were analyzed by gas chromatography-mass spectrometry. The data obtained, together with their infrared spectra, indicated that they are phenylacetic acid, unsaturated fatty acids such as octenoic, nonenoic, and nonedienoic acids, and saturated fatty acids such as nomnanoic and heptanoic acids. The antifungal substances in F-1 one of the organic acid fractions, showed much higher levels in the infected and the recovered laver than in the normal laver.


Taking placing raft foundation of NOVOTEL IBIS Hotel in the United Arab Emirates as an example,this article described the application of pumping concrete in placing raft foundation and proposed an actual method for preventing mass concrete crack.


The reproductive process promotes morphophysiological and behavioral changes in fish species throughout their life cycle. Its success is vital to define their resilience in the environment. This study aimed to evaluate the reproductive biology of the endemic fish species Astyanax bifasciatus in a tributary of the Lower Iguaçu River Basin, Paraná, Brazil. Fish were collected monthly at four sites along the Jirau Alto River in the city of Dois Vizinhos from October 2015 to September 2016. A standardized catch effort with gill nets and fish traps was used. In the laboratory, standard length and total weight were recorded. After anesthesia, the animals were sectioned to macroscopically determine the sex, sexual maturity stage, and presence of celomatic fat. The gonads and liver were removed to determine the gonadosomatic and hepatosomatic indexes, respectively. A total of 160 individuals (104 females and 56 males) were used. The gonadosomatic index, frequency of the gonadal maturation stages, and condition factor showed a long reproductive period with two investment cycles for both sex. Length at first sexual maturity was 4.57 cm for females and 3.56 cm for males. The reproductive data corroborate the generalist profile of the species and demonstrate a high degree of adaptive capacity, even in smaller tributaries.


Program slicing has many applications such as program debugging, testing, maintenance, and complexity measurement. This paper concerns the problem of slicing concurrent object-oriented programs that has not been addressed in the literatures until now. To solve this problem, we propose a new program dependence representation named the system dependence net (SDN), which extends previous program dependence representations to represent concurrent object-oriented programs. An SDN of a concurrent object-oriented program consists of a collection of procedure dependence nets each representing a main procedure, a free standing procedure, or a method in a class of the program, and some additional arcs to represent direct dependences between a call and the called procedure/method and transitive interprocedural data dependences. We construct the SDN to represent not only object-oriented features but also concurrency issues in a concurrent object-oriented program. Once a concurrent object-oriented program is represented by its SDN, the slices of the program can be computed based on the SDN as a simple vertex reachability problem in the net.


Abstract The recent progress accomplished in our research group is here presented. Firstly porous Si (PS) microcavities were formed on p-type-doped (6-9ωcm) substrates with very narrow bandwidth (6 nm) and a good ratio of the peak to background emission, reaching at the same time a high emission quantum efficiency. Secondly light-emitting diodes (LEDs) based on n-type-doped Si/PS heterojunctions were studied. The improvement in the proposed LED structure with respect to the usual metal/PS LED is demonstrated. Anodic oxidation experiments show further improvements in the LED efficiency. Thirdly, SiO2/ Si/SiO2 quantum wells with room-temperature efficient light emission in the visible range were investigated. We report here the preparation and photoluminescence properties of thin SiO2/Si layers obtained by low-pressure chemical vapour-phase deposition and thermal oxidation processes. The growth technique is fully compatible with standard very-large-scale integration complementary metal-oxide-semiconductor technology.


Convolutional Neural Networks (CNNs) and Graphic Processing Units (GPUs) are now increasingly adopted in many cutting edge safety-critical applications. Consequently, it is crucial to evaluate the reliability of these systems, since the hardware can be affected by several phenomena (e.g., wear out of the device), producing permanent defects in the GPU. These defects may induce wrong outcomes in the CNN that may endanger the application. Traditionally, the study of the effects of permanent faults on CNNs has been approached by resorting to application-level fault injection (e.g., acting on the weights). However, this approach has restricted scope, and it may not reveal the actual vulnerabilities in the GPU device. Hence, a more accurate evaluation of the fault effects is required, considering more in-depth details of the device's hardware. This work introduces a more elaborated experimental evaluation of the impact of GPU's permanent faults on the reliability of a CNN by resorting to a Software-Implemented Fault Injection(SWIFI) strategy, considering faults at the hardware level. The results of the fault simulation campaigns we performed on the GPU data-path cores are compared with those at the application level, proving that the latter ones are generally optimistic.


Summarizing of experimental studies results of the local MHD-interaction at hypersonic air flow near the plate is presented. Pulsed and radiofrequency discharge have been used for the flow ionization. It is shown that MHD-effect on the shock-wave structure of the flow is significant at test conditions. Using of MHD-interaction parameter enabled to defining characteristic modes of MHD-interaction by the force effect: weak, moderate and strong.


apneic ventilation decreases lung injury and fibroproliferation in an ARDS model with ECMO. Am J Respir Crit Care Med [online ahead of print] 14 Sep 2018; DOI: 10.1164/rccm.201805-0869OC. 3. Gattinoni L, Pesenti A, Mascheroni D, Marcolin R, Fumagalli R, Rossi F, et al. Low-frequency positive-pressure ventilation with extracorporeal CO2 removal in severe acute respiratory failure. JAMA 1986;256: 881–886. 4. Johannes A, Kredel M, Zollhoefer B, Schlegel N, Von Kirschbaum C, Brederlau J, et al. Influence of apneic oxygenation and minimal tidal volumes on ventilator-associated lung injury. Minerva Anestesiol 2014;80:526–536. 5. Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, et al.; OSCILLATE Trial Investigators; Canadian Critical Care Trials Group. High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 2013;368:795–805. 6. Cavalcanti AB, Suzumura ÉA, Laranjeira LN, Paisani DM, Damiani LP, Guimarães HP, et al.; Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART) Investigators. Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome–a randomized clinical trial. JAMA 2017;318:1335–1345. 7. Araos J, Alegria L, Soto D, Garcia P, Garcia A, Dubo S, et al. How much airway pressure to apply while resting the lungs in severe ARDS supported with ECMO? [abstract]. Presented at ESICM LIVES 2018. October 24–28, 2018, Paris, France. 8. Marhong JD, Telesnicki T, Munshi L, Del Sorbo L, Detsky M, Fan E. Mechanical ventilation during extracorporeal membrane oxygenation: an international survey. Ann Am Thorac Soc 2014;11:956–961. 9. Schmidt M, Stewart C, Bailey M, Nieszkowska A, Kelly J, Murphy L, et al. Mechanical ventilation management during extracorporeal membrane oxygenation for acute respiratory distress syndrome: a retrospective international multicenter study. Crit Care Med 2015;43: 654–664. 10. Franchineau G, Bréchot N, Lebreton G, Hekimian G, Nieszkowska A, Trouillet JL, et al. Bedside contribution of electrical impedance tomography to setting positive end-expiratory pressure for extracorporeal membrane oxygenation-treated patients with severe acute respiratory distress syndrome. Am J Respir Crit Care Med 2017;196:447–457. 11. Combes A, Hajage D, Capellier G, Demoule A, Lavoué S, Guervilly C, et al.; EOLIA Trial Group, REVA, and ECMONet. Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. N Engl J Med 2018;378:1965–1975.


Croton cajucara Benth. ('sacaca') is a tree of the Euphorbiaceae family, native to the Amazon region in northern Brazil, where it is widely used in the popular treatment of various diseases. Its active principle, the terpenoid trans-dehydrocrotonin, has been credited with a variety of medical properties, including antiulcer, antiinflammatory, antitumor, antimutagenic and hypoglycemic activity. In this investigation, possible mutagenic and antimutagenic effects were evaluated in treatments using methanol extract of this plant on Swiss Albino mice by examining their peripheral blood cells for micronuclei. In these tests, the material obtained by methanol extraction of C. cajucara tree bark was administered to the mice by gavage. None of the doses evaluated in this study presented mutagenicity. Analysis of the results obtained from studies evaluating antimutagenicity revealed protection against the chemotherapeutic agent cyclophosphamide for the two highest doses used.


The Absolute is claimed to be knowable, hence the proper object of the science of philosophy. After Kant has clearly stated the exact opposite - beyond the physical we know nothing - 'metaphysical knowledge' sounds like a contradiction in terms. Nevertheless, German idealists think themselves true Kantians and at the same time endeavor to know the Absolute. The key to knowledge of the Absolute is thought to be found in our subjectivity, in the immediate consciousness of our own existence. The awareness 'I am' is to be the first step towards understanding 'all that is'. This chapter presents an overview of the Kantian 'Copernican Revolution'. In order to understand the philosophies of German idealism, it is necessary to learn more about the major concepts of Spinoza's philosophy. Therefore, the chapter discusses the basics of Spinozism.Keywords: absolute idealism; Copernican revolution; German idealism; Kantian; Spinozism


Abstract Minimal residual disease (MRD) is the strongest predictor of relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In BLAST study (NCT01207388), adults with BCP-ALL in remission with MRD after chemotherapy received blinatumomab, a CD19 BiTE® immuno-oncotherapy, 15 µg/m2/day for up to four 6-week cycles (4 weeks continuous infusion, 2 weeks off). Survival was evaluated for 110 patients, including 74 who received HSCT in continuous complete remission. With a median follow-up of 59·8 months, median survival (months) was 36·5 (95% CI: 22.0–not reached [NR]). Median survival was NR (29.5–NR) for complete MRD responders (n = 84) and 14.4 (3.8–32.3) for MRD non-responders (n = 23; p = 0.002); after blinatumomab and HSCT, median survival was NR (25.7–NR) (n = 61) and 16.5 (1.1–NR) (n = 10; p = 0.065), respectively. This final analysis suggests complete MRD response during blinatumomab treatment is curative. Post-hoc analysis of study data suggests while post blinatumomab HSCT may be beneficial in appropriate patients, long-term survival without HSCT is also possible.


The production of the Ivorian sorghum beer known as tchapalo remains more or less an empirical process. The use of starter cultures was therefore suggested as the appropriate approach to alleviate the problems of variations in organoleptic quality and microbiological stability. In this study, we evaluated the capacity of S. cerevisiae and C. tropicalis to produce sorghum beer as freeze-dried starter in mixed or pure cultures. Beers produced with mixed freeze-dried cultures of S. cerevisiae F12-7 and C. tropicalis C0-7 showed residual sugars and ethanol contents similar to beers obtained with S. cerevisiae F12-7 pure culture, but the total sum of organic acids analyzed was the highest with the mixed culture (15.71 g/L). Higher alcohols were quantitatively the largest group of volatile compounds detected in beers. Among these compounds, 2-phenyl ethanol, a higher alcohol that plays an important role in beer flavor, was highly produced with the mixed culture (10,174.8 µg/L) than with the pure culture (8749.9 µg/L).


Systematic studies have been carried out on two different powder materials used for additive manufacturing: stainless steel and cobalt-chrome. An extensive array of characterization techniques were applied to these two powders. The physical techniques included laser-diffraction particle-size analysis, X-ray computed tomography for size and shape analysis, and optical and scanning electron microscopy. Techniques sensitive to chemistry included X-ray diffraction and energy-dispersive analytical X-ray analysis. The background of these techniques will be summarized and some typical findings comparing different samples of virgin additive manufacturing powders, taken from the same lot, will be given. The techniques were used to confirm that different samples of powder from the same lot were essentially identical, within the uncertainty of the measurements.


Defining the quality assurance program for the US Dept. of Energy Shippingport Station Decommissioning Project (SSDP) was a unique opportunity because this is the first full-sized commercial nuclear power plant to be decommissioned. General Electric Co. defined a quality assurance program that provided adequate control, yet was stripped down to the essentials. The program is designed to provide a flexible degree of monitoring of subcontractor work, built around a core of radiation safety monitoring, detailed planning, inspection, and auditing, and operated with a minimum of dedicated personnel. This paper concentrates on the traditional quality assurance activities.


The objective of this study was to determine the types of traps that were effective in trapping horn beetles (O. rhinoceros L.). The research was conducted in Latuhalat Village, Nusaniwe District, Ambon Municipality, from September till November 2016. The treatment consisted of light trap, pheromone trap and pheromone and light trap. Observations were done on the number of imago of O. rhinoceros L. trapped and its sex ratio on each treatment. The results showed that pheromone trap was the most effective trap on O. rhinoceros L.


It explains the reason of gentle breeze syntony about sustained tubate generatrix in hydromechanical viewpoint,and puts forworld several methods for avoiding gentle syntony.


During mitosis, proteins undergo a variety of post‐translational modifications (PTM) in order to alter function and localization. Our objective is to determine the interplay between O‐GlcNAcylation and phosphorylation on proteins during mitotic progression. O‐GlcNAc is the attachment of a single N‐acetylglucosamine moiety to serine and threonine residues in nuclear and cytoplasmic proteins. O‐GlcNAc transferase (OGT) adds the modification and O‐GlcNAcase (OGA) removes the modification. O‐GlcNAc is similar to phosphorylation as both modifications are responsive to the extracellular environment, nutrients, and growth hormones. Using SILAC (Stable Isotope Labeling of Amino Acids in Cell culture) labeling, we are able to quantitate differences in cells with either an OGT or OGA gain of function. Combined samples were digested and fractionated to enrich for O‐GlcNAcylated or phosphorylated peptides. We identified numerous proteins whose expression or phosphorylation status was altered by aberrant O‐GlcNAcylation. These results demonstrate the interconnectedness of these two modifications in regulating mitotic progression. Furthermore, these data suggest that diseases that disrupt one PTM will also alter the actions of the other PTM.