Previous work (Pearson, 1950; Pearson et al., 1952; and Visser et al., 1952) showed that various compounds may inhibit Theiler's GDVII strain of mouse encephalomyelitis virs in vitro; none tested so far was effective in vivo. It was of interest to determine if compounds capable of depressing centrl nervous stem activity would also repress virl activity. The present report gives the results of trials with various agents tested, mostly in vitro.


The controlled-source electromagnetic (CSEM) method is a proven and promising geophysical technique in the hydrocarbon exploration area. Recently, there is increasing interest in applying it to CO2-injection monitoring in both land and marine environments. For example, a marine CSEM survey has been carried out in the Sleipner area in 2008 to map the CO2 plume in the Utsira formation. There are still scientific and technical issues to resolve and improve further. In the current study, we focus on two particular issues. The first is to explore the possibility of modeling the CO2 plume in the Utsira formation at the Sleipner area by means of an effective anisotropic resistivity layer. The second is the application of so-called surface-to-borehole CSEM in order to increase the sensitivity of CSEM data to the CO2 plume. © 2013 The Authors. Published by Elsevier Ltd. Selection and/or peer-review under responsibility of GHGT


A 31-year-old Hispanic woman presented to the dermatoiogy clinic with a 1-year history of painful oral ulcers. She had seen several physicians and had been treated with various medications including acyclovir, Kenalog in orabase (triamcinolone acetonide), penicillin, and tetracycline without significant improvement. A prior trial of prednisone (5 mg per day) had reportedly improved her lesions. A review of systems was significant for fatigue, occasional hematochezia, and rare epistaxis. She had not experienced arthralgias, Raynaud's symptoms, photosensitivity, xerophthalmia, xerostomia, rashes, or genital lesions. She obtained regular gynecologic and internal medicine examinations, which were unremarkable. Her past medical history included allergic rhinitis. She reported no family history of collagen vascular disease, bullous skin diseases, oral ulcers, or drug allergies. On examination her lower labial mucosa had several 2-4 mm shallow erosions with red-brown crusting at the periphery of the lesions. Her buccal mucosa was covered with many 5-10 mm shallow red ulcerations with whitish borders and ragged edges. Similar lesions were present on her soft and hard palate. Her tongue was uninvolved. The rest of her cutaneous examination was unremarkable. Normal or negative laboratory studies included a complete blood count, SMA 17, antinuclear antibodies, herpes culture, and bacterial culture. In the more than 18 months since her disease began she has had no change in her history or physical examination that would be suspicious for a neoplastic process. During this time the blistering has been limited to her oral mucosa.


Automated Number Plate Recognition (ANPR) has become essential part of traffic control system because of unconstrained increased of vehicles on roads which make it difficult to control. On or after analysis of diverse author's exertion, ANPR has six imperative parts like Image Acquisition, Pre-processing, edge detection, segmentation, feature extraction and recognition. Characters recognition is turn out to be difficult everyday jobs due to variations of number plate. The intentioned system is mainly focus on classification and recognition of characters using Kstar Machine learning algorithm. The classification characters present better performance using Kstar. A comparative study is done between these classifiers based upon their considerations like average accuracy, precision, recall and F-measure. Performance is deliberated using precision, recall and F-measure. The results give you an idea about that K STAR algorithm completes better with Recognition Rate and it achieved an accuracy of 99%.


Spectral properties of matrices and graphs, S. Stefani, A. Torriero New insights on the sign stability problem, J. Maybee Irreducible matrices and primitivity index, L.G. Ceccarossi Comparison of algorithms for symmetrical matrices Eigenanalysis, S. Camiz, V. Tulli Cubic graphs as model of real system, T. Calamoneri, R. Petreschi Lower bounds for a class of depth-two switching circuits, Z. Tuza Cluster identification in a signed graph by Eigenvalue analysis, A. Bellacicco, V. Tulli Graphical Gaussian models and regression, G.I. Lasinio, P. Vicard Linear structural dependence of degree one among data: a statistical model, F. Lagona I/O analysis: old and new analysis techniques, S. Camiz Hadamard matrix product, graph and system theories: motivations and role econometrics, M. Faliva Graphs and macroeconometric modelling, M. Gilli Quantitative solvability analysis in multiequation models, M. Gilli, G. Pauletto International comparisons and construction of optimal graphs, B.M. Zavanella.


We report identification and characterization of Kv6.3, a novel member of the voltage-gated K channel. Reverse transcriptase-polymerase chain reaction analysis indicated that Kv6.3 was highly expressed in the brain. Electrophysiological studies indicated that homomultimeric Kv6.3 did not yield a functional voltage-gated ion channel. When Kv6.3 and Kv2.1 were co-expressed, the heteromultimeric channels displayed the decreased rate of deactivation compared to the homomultimeric Kv2.1 channels. Immunoprecipitation studies indicated that Kv6.3 bound with Kv2.1 in co-transfected cells. These results indicate that Kv6.3 is a novel member of the voltage-gated K channel which functions as a modulatory subunit. ß 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.


An empirical approach to estimate the reduced scattering (μs') and absorption (μa) coefficients of a turbid medium from time-resolved diffuse reflectance detected at multiple source-detector separations (SDS) is described. The dependence of the temporal point spread function (TPSF) on the medium's optical properties has been previously well studied. Here, we exploit these findings by using the difference in photon arrival-times obtained from a pair of SDS at the (a) peak intensity and (b) longer-time trailing edge of the TPSF to estimate the transport coefficients. This difference may have little dependence on the instrument response functions (IRF). Consequently, real-time quantitation is possible since the method does not depend on non-linear fitting of measured reflectance and/or deconvolving the IRF. The approach uses Monte Carlo simulations to directly translate the difference in arrival times of the temporal reflectance profiles at multiple SDS into the medium's optical properties. Here, we show that a small range in the optical properties could be defined using a pair of time differences in the TPSF.


In recent years, Great attention has been shown to the question of copyright infringement of 'Online Service Provider'(OSP). For the most...


MALTA is a depleted monolithic active pixel sensor (DMAPS) developed in the Tower Semiconductor 180-nm CMOS imaging process. Monolithic CMOS sensors offer advantages over current hybrid imaging sensors in terms of both increased tracking performance due to lower material budget and ease of integration and construction costs due to the integration of read-out and active sensor into one ASIC. Current research and development efforts are aimed toward radiation hard designs up to 100 Mrad in total ionizing dose (TID) and $1\,\, \times 10 ^{15}~1~\text {MeV}\text {n}_{\text {eq}}/\text {cm}^{2}$ in nonionizing energy loss (NIEL). The design of the MALTA sensors was specifically chosen to achieve radiation hardness up to these requirements and satisfy current and future collider constraints. The current MALTA pixel architecture uses small electrodes which provide less noise, higher signal voltage, and a better power-to-performance ratio. To counteract the loss of efficiency in pixel corners, modifications to the Tower process have been implemented. The MALTA sensors have been tested during the 2021 and 2022 SPS CERN Test Beam in the MALTA telescope. The telescope ran for the whole duration of the beam time and took data to characterize the novel MALTA2 variant and the performance of irradiated samples in terms of efficiency and cluster size. These campaigns show that MALTA is an interesting prospect for HL-LHC and beyond collider experiments, providing both very good tracking capabilities and radiation hardness in harsh radiation environments.


Modelling network traffic is gaining importance to counter modern security threats of ever increasing sophistication. It is though surprisingly difficult and costly to construct reliable classifiers on top of telemetry data due to the variety and complexity of signals that no human can manage to interpret in full. Obtaining training data with sufficiently large and variable body of labels can thus be seen as a prohibitive problem. The goal of this work is to detect infected computers by observing their HTTP(S) traffic collected from network sensors, which are typically proxy servers or network firewalls, while relying on only minimal human input in the model training phase. We propose a discriminative model that makes decisions based on a computer's all traffic observed during a predefined time window (5 minutes in our case). The model is trained on traffic samples collected over equally-sized time windows for a large number of computers, where the only labels needed are (human) verdicts about the computer as a whole (presumed infected vs. presumed clean). As part of training, the model itself learns discriminative patterns in traffic targeted to individual servers and constructs the final high-level classifier on top of them. We show the classifier to perform with very high precision, and demonstrate that the learned traffic patterns can be interpreted as Indicators of Compromise. We implement the discriminative model as a neural network with special structure reflecting two stacked multi instance problems. The main advantages of the proposed configuration include not only improved accuracy and ability to learn from gross labels, but also automatic learning of server types (together with their detectors) that are typically visited by infected computers.


OBJECTIVE To set up a RP-HPLC method for the determination of mosapride citrate in Mosapride Citrate Orally Disintegrating Tablets.METHODS Diamonsil C_(18)column(4.6mm×250mm,5μm) was used as the stationary phase,0.02mol·L~(-1) sodium dihydrogen phosphate(containing sodium heptanesulfonate,adjusted pH value to 5.4 with sodium hydroxide)-acetonitrile(40∶60)was used as the mobile phase at the flow rate of 1.0ml·min~(-1).The detection wave-length was 274nm.RESULTS The calibration curve was linear in the range of 40~120μg·ml~(-1),the regression coefficient was 0.9999.The recovery of method was 99.2%,RSD was 0.4%(n=9).CONCLUSION The method was simple,quick and reliable.


The study of eye motions involved in the vestibular ocular reflex (VOR) is a key tool for understanding the performance of the vestibular system and for the diagnosis of dysfunction. Limitations in experimental equipment and in the analytic methods applied have resulted in VOR testing being conducted under artificial laboratory conditions that do not resemble the conditions under which the VOR naturally functions. The results from these tests are often unreliable, and may, in fact, misrepresent the function and performance of the VOR and the vestibular system. The purpose of this thesis was to develop the experimental equipment, protocol, and analysis algorithms required to conduct a stochastic system identification of the horizontal, rotational VOR, while it was being used to stabilize gaze during natural, head-free tracking. By providing statistically uncorrelated stimuli to the visual and vestibular systems, estimates of the VOR's impulse response function could be made as subjects tracked a visual target that moved with an unpredictable trajectory. A novel stochastic technique was developed to generate the visual and vestibular input sequences such that they had appropriate amplitude distributions, and autoand cross-correlation functions. The results showed that the technique was able to identify the dynamics of the VOR over the frequency range that it naturally functions to stabilize gaze, that is from below 0.5 Hz through 4.0 Hz. Nonlinearities in the head-neck control system limited the analysis at low frequencies, and difficulties in calculating high frequency eye velocities limited the accuracy of the analysis at high frequencies. Unlike the rotational VOR tests that are commonly used today, this technique was able to distinguish between the visually and vestibularly driven eye responses, and was able to show that during head-free gaze tracking, the vestibular system is able to compensate for head disturbances with a near unity gain. Thesis Supervisor: Lynette A. Jones Title: Principle Research Scientist


After decades of scientific debate about global warming and a dramatic increase of public and political awareness in the last five years, the notion of climate change and the need for action has finally arrived on the desks of Ho Chi Minh City's (HCMC) administration. City officials are now obliged by the national government to set up adaptation measures. The prevailing urban development practice leading to environmental hazards and increased exposure to climate change is now likely to be reconsidered. The Megacity Research Project HCMC "Integrative Urban and Environmental Planning Framework - Adaptation to Climate Change" aims to use this window of opportunity to develop, implement and institutionalize inno- vative planning instruments for an urban development, which is better adapted to the local environment. This paper shows the interrelation of current urban development challenges and future climate change impacts and gives an introduction to the Megacity Research Project HCMC. Hereby, barriers and opportunities will be discussed towards the implementation of climate change response measures.


A passionate biography of the Australian artist Kathleen McArthur (1915-2001). This book reveals relationship between native plants and the larger ecological balance in Australia. Review(s) of: Margaret Somerville, Wildflowering: The Life and Places of Kathleen McArthur, UQP, $24.95 pb, ISBN 0702234508.


IoT smart energy management is to maximize energy efficiency through energy information collection, energy DR management and energy sharing/trading by developing IoT-based smart energy platform technology. IoT smart energy management services provide energy efficiency enhancement, energy sharing and trading services through interconnection and integration of energy supply-transfer-utilization energy systems using the Internet of things. For this, this paper shows IoT energy management platform with energy big data system.


The creation of realistic models of amorphous silica has been studied using the Monte Carlo based method of Wooten, Winer, and Weaire, where the bond-topology is optimized with respect to an interatomic potential model. The commonly used Keating potentials are compared and their strengths and weaknesses are assessed. The mean oxygen bond-angle obtained using these potentials turned out to be too small. A modification of the potential parameters is shown to correct this feature and thus produce better results when used with the Wooten-Winer-Weaire method.


The paper discusses the question whether currently emerging, new forms of non-monogamous intimate relationships generate new class and gender relations. Parts of the polyamory movement propagate that breaking with hegemonic norms in relationships opens up the possibility for replacing internalized patriarchal and capitalistically structured norms and behaviour patterns with ones that are to a higher degree self-reflexive and self-determined. Parts of the research about polyamory agree that there is emancipatory potential and stress the possibility of these relationships to break with heteronormative and sexist power struc-tures and to initiate social change in various domains. However, it is just as feasible that poly-amory is a relationship form that aids in managing the demands of a highly flexible, project-oriented capitalist system. The paper outlines my qualitative method of research – a triangulation of intersectional multi-level analysis and network analysis – as well as my ideas for a care-theoretical approach to understanding polyamorous practices. Based on preliminary results of my doctoral research the paper leads to the conclusion that emancipatory aspirations are especially likely to succeed when they are supported by structural measures like collec-tive housekeeping or obligatory modes of communication.


The purpose was (1) to determine the functions and powers of summer session directors; (2) to compare those I functions and powers actually assumed with the judgment ! of an eminent "jury" of ten authorities in summer session j administration as to what degree they should be performed. A Surrey Questionnaire, relating to (1) college adminis tration; (2) curriculum; (3) instructional faculty; (4) stu dents; and (5) general administration, was prepared and mailed to all four-year accredited institutions of higher education with enrollments exceeding 1500 students. Institu tions were categorized according to (1) small; (2) inter mediate; and (3) large size. Also categorized according to accrediting regions of the U.S. and whether they were "public" or "private" schools. Comparisons were made as to the functions and powers assumed (performed) by the different size institutions with the judgment of the "jury." Thirty-seven percent of the directors reported being directly responsible to the "president" of the institution. (The jury felt they should be.) Twenty-nine percent re ported that they "always" had the power to determine summer session faculty salaries. (The jury felt they should not.) Twenty-eight percent reported that they were "always" responsible for attendance and discipline. (The jury felt they should not be.) Forty-two percent reported that they were "always" responsible for registration pro cedures. (The jury felt they should not be.) Only four per cent reported spending 90-100 percent of their time in summer session administration during the regular-year. The most common title was "director". The directors were responsible to either the "president" or "vice-president." Most of them had "autonomy" in budgetary expenditures. Most of the directors submitted an "Annual Report." Most of the directors had the power to appoint "visiting faculty." Many of the directors took the leadership in suggesting student class load, fees, et cetera. Most of the summer session programs were "self-supporting" financially. Directors should spend more time on summer session administration during regular-year. THE PURPOSE of the study was (1) to determine the functions and powers of summer session administrators, as revealed through a normative survey of summer ses sion directors in selected institutions of higher education in the United States as they related to institution admin istration, curriculum, instructional faculty, students, and general college and university administration; (2) to ascertain the degree to which an eminent jury of ten authorities in the field of higher education and summer session administration felt that the summer session di rector should assume, or perform, those functions and powers; and (3) to compare the degree to which the sum mer session directors assumed, or performed, those func tions and powers with the degree to which the eminent jury of experts felt that the summer session director should assume, or perform those functions and powers. Design of the Study Methods and Procedures Employed in Gath ring the Data for the Study The first phase of the study was to make a review of the l terature to determine the functions and powers which characterize the summer session director. A survey questionnaire was prepared and mailed to all four-year accredited institutions of higher education in the United States which had an enrollment during the 1963-64 aca demic year of 1500 or more students. The study was re lated to the 1964 Summer Session director. There were 440 such institutions of higher education, which were included in the study. Three hundred and forty institutions responded for a 77.27 per cent return of the questionnaires. A number of the questionnaires (66) were unusable. Two responses were unusable be cause of incompleteness. Sixty-four responses were un usable because the institutions did not meet the delimita tion criteria of the study in that they did not have a sum mer session, or a summer session administrator, or be cause the institution's summer session was an integral part of the regular academic-year. There were 274 usable questionnaires, 62.27 per cent of the total population of the institutions surveyed. These returns were IBM card-punched and data processed by a 1620 IBM Data Processing Computer System, and were the basis for the statistics and tables in the study. The institutions were categorized according to (1) small, intermediate, and large size enrollment institu tions; (2) type of control (private or public) ; and (3) accrediting regions of secondary and higher education in the United States. The largest percentage of usable returns was received from the New England Region (77 per cent), the Northwest Region (75 per cent), and from the Western Region (72 per cent). The largest percentage of usable returns according to categories was received from the intermediate size in stitutions of the New England Region (100 per cent), the large size institutions of the Western Region (90 per cent), and from the intermediate size institutions of the Northwest Region (89 per cent). Comparisons were made with regard to the extent to which the summer session directors assumed, or per formed, certain functions and powers as they related to (1) institution administration; (2) the curriculum; (3) instructional faculty; (4) the students; and (5) general college and university administration. This content downloaded from 188.8.131.52 on Thu, 20 Oct 2016 04:08:10 UTC All use subject to http://about.jstor.org/terms


We describe a patient with Hashimoto's encephalopathy presenting as long‐standing episodes of aphasia associated with migraine‐like headache. Repeated thyroid hormone levels were within normal values, but high titers of antithyroid antibodies in serum, and diffuse EEG slowing and CSF abnormalities during one episode led to the diagnosis.


Cite this article as: Biswas J. Commentary: As is our pathology, so is our practice. Indian J Ophthalmol 2019;67:1996. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‐NonCommercial‐ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‐commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Commentary: As is our pathology, so is our practice


A phenotypically normal male mouse, investigated because it was sterile, was found to possess 41 chromosomes. A karyotypic analysis indicated the extra element was one of the smallest chromosomes, almost certainly the Y. X-Y bivalents, Y-Y bivalents and XYY univalents were seen in meiotic metaphase I cells, and it was therefore concluded that the extra chromosome was indeed the Y. Spermatogenesis tended to break down after meiosis I, but a few spermatids and sperm were observed.


Studies were performed in order to find out whether the duration of immunologic memory is impaired when priming is done at a time in which the primary anti-body-forming capacity begins to decrease, i.e., at an age of about 12 months. Female NMRI mice of either 3 (optimally responding animals) or 12 months were primarily immunized with a 'saturated' dose of 4 × 108 sheep erythrocytes. Both groups of animals were boosted either 1 4, or 8 months after primary antigenic stimulation. The immune responses were measured by the direct and indirect antibody plaque techniques and by serological procedures. There was no significant difference regarding the secondary immune potential of both mouse groups on all examinations.


Many uncrewed underwater vehicles (UUV) missions are currently planned, executed, and analyzed with minimal environmental awareness. One common UUV operation is to detect and classify targets of interest within the water column or on the seafloor utilizing sonar, video imagery, and LiDAR (Light Detection and Ranging). When UUVs operate independent of environmental conditions, and conditions are unfavorable, poor data quality and resulting possible missed detections are more likely. Often the only remedy is costly secondary deployments occurring hours to days later, if at all. If deleterious conditions can be determined heuristically (e.g. low-quality data can be predicted) based on environmental conditions, then the UUV or its operators can take corrective actions before the deployment has concluded.Here, we compare historic UUV high frequency sidescan sonar and video imagery data quality with UUV observed in situ environmental conditions. Analysis of the video imagery found that qualitative measures of observable water clarity (i.e. none, poor, moderate, good) were significantly correlated (95% Confidence Intervals) with onboard UUV turbidity value measurements. We also analyzed several instances of operator observed refraction in the high frequency sonar imagery and found potential linkages to variations in ambient temperature and sound speed as observed by the vehicle in situ in the searchable sonar area.


The history, development and actuality of procuratorial work, deepening of procuratorial reform and the epoch require the innovation of procuratorial theory. To innovate in the procuratorial theory, the idea of development together with the time should be persevered in and several points should be properly managed as follows: (1) the relation of succeeding, developing and reference; (2) the relation of study on basic theory and application theory; (3) the relation of innovation and Marxist juridical method.


On the basis of summarizing the traditional industry cluster,the method is put forward to research the industrial cluster as a part of the human economical system by using the result of research on ecology theory,which is of great significance to advance the research on the industrial cluster and guide its development.


Background Impaired endothelial function is thought to contribute to the increased cardiovascular risk associated with above‐normal blood pressure (BP). However, the association between endothelial function and BP classified by 2017 American College of Cardiology/American Heart Association guidelines is unknown. Our objective was to determine if endothelial function decreases in midlife/older adults across the 2017 American College of Cardiology/American Heart Association guidelines BP classifications and identify associated mechanisms of action. Methods and Results A retrospective analysis of endothelial function (brachial artery flow‐mediated dilation) from 988 midlife/older adults (aged 50+ years) stratified by BP status (normal BP; elevated BP; stage 1 hypertension; stage 2 hypertension) was performed. Endothelium‐independent dilation (sublingual nitroglycerin), reactive oxygen species–mediated suppression of endothelial function (∆brachial artery flow‐mediated dilation with vitamin C infusion), and endothelial cell and plasma markers of oxidative stress and inflammation were assessed in subgroups. Compared with normal BP (n=411), brachial artery flow‐mediated dilation was 12% (P=0.04), 15% (P<0.01) and 20% (P<0.01) lower with elevated BP (n=173), stage 1 hypertension (n=248) and stage 2 hypertension (n=156), respectively, whereas endothelium‐independent dilation did not differ (P=0.14). Vitamin C infusion increased brachial artery flow‐mediated dilation in those with above‐normal BP (P≤0.02) but not normal BP (P=0.11). Endothelial cell p47phox (P<0.01), a marker of superoxide/reactive oxygen species–generating nicotinamide adenine dinucleotide phosphate oxidase, and circulating interleukin‐6 concentrations (P=0.01) were higher in individuals with above‐normal BP. Conclusions Vascular endothelial function is progressively impaired with increasing BP in otherwise healthy adults classified by 2017 American College of Cardiology/American Heart Association guidelines. Impaired endothelial function with above‐normal BP is mediated by excessive reactive oxygen species signaling associated with increased endothelial expression of nicotinamide adenine dinucleotide phosphate oxidase and circulating interleukin‐6.


Abstract In the Himalayas land above the tree limits is used as alpine pasture for grazing cattle during summer months. This paper determines the extent of such alpine pastures in the eastern and western Himalayas using Landsat MSS data for the period 1981-1984. The results of the study will be found useful for formulating management plans for improving the productivity of the alpine pastures to sustain the grazing of the cattle in these pastures.


We apply a graph-based Transduction Algorithm with COnfidence named TACO to the task of phoneme classification. In recent work, TACO outperformed two state-of-the-art transductive learning algorithms on several natural language processing tasks. However, although TACO is a general-purpose algorithm, it has not yet been used for tasks in other domains, nor applied to graphs with millions of vertices. We show its effectiveness, as well as its scalability, by performing transductive phoneme classification on data from the TIMIT speech corpus. In addition, we experiment with two methods for graph construction, including local scaling, previously used for unsupervised clustering. Our results show that local scaling combined with TACO outperforms other combinations of graph construction methods and graph-based transductive algorithms.


This paper proposes a geometrically based propagation model for an urban mobile environment that establishes a relationship between the angle-of-arrival and time-of-arrival of multipath components. The model is characterized by the geometric locations of a base station and mobile station among urban city structures. This model comprises three sets of propagation characteristics: the street-microcell propagation characteristics around mobile stations; the reflection and scattering characteristics around reflection areas; and the macrocell propagation characteristics from the reflection area to the base station. In particular, by using the propagation characteristics of a street-microcell around the mobile station, a more realistic model is established compared to previous models, which were based on circular or elliptic reflective areas.


We report on a magnetophotoluminescence study of single self-assembled semiconductor nanorings which are fabricated by molecular-beam epitaxy combined with AsBr3 in situ etching. Oscillations in the neutral exciton radiative recombination energy and in the emission intensity are observed under an applied magnetic field. Further, we control the period of the oscillations with a gate potential that modifies the exciton confinement. We infer from the experimental results, combined with calculations, that the exciton Aharonov-Bohm effect may account for the observed effects.


Film-coating materials for pharmaceutical product is one of the core technology in pharmaceutical industry with the advantages of better stability,coating of shorter time,less increase weight and better resistance of wet,including the stomach dissolve type,intestines dissolving type,and slow release and controlled-release type,etc..This paper reviewed the three types of thin film coating materials,the application and progress in pharmaceutical product.


We [Hawi et al. (2005); Am J Hum Genet 77:958–965] reported paternal over‐transmission of risk alleles in some ADHD‐associated genes. This was particularly clear in the case of the DAT1 3′‐UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over‐transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three‐replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3′‐UTR VNTR, respectively) of DAT1. In addition, a similar pattern of over‐transmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal over‐transmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon. © 2009 Wiley‐Liss, Inc.


The composition and quantity of Freund-type adjuvant injected, the route of injection, and reaction at the depot site were studied for their roles in producing polyarthritis in rats. The intra-dermal injection of Myobacterium butyricum in oil induced arthritis with much higher frequency than the subcutaneous or intravenous route. The minimal effective intradermal dose was 0.06 mg. M. butyricum in 0.02 ml. oil; 0.6 mg. mycobacteria in 0.1 ml. oil was required to produce polyarthritis in 100 per cent of rats. Wax fractions of mycobacteria did not induce arthritis. Neither a depot of adjuvant nor inflammation at the injection site was important as polyarthritis developed, even though amputation of the tail to remove the depot of injected adjuvant was performed within 2 hours after injection. While the mechanism of adjuvant-induced polyarthritis remains unknown, the joint disease appeared dependent upon specific sites of dissemination of the adjuvant.

Le composition e le quantitate de adjuvante typo Freund, le via de injection usate, e le reaction a1 sito del deposito esseva studiate con respecto a lor rolos in le production de polyarthritis in rattos. Le injection intradermal de Mycobacterium butyricum in oleo induceva arthritis multo plus frequentemente que le injection subcutanee o intravenose del mesme preparato. Le minime efficace dose intradermal esseva 0,06 mg de M. butyricum in 0,02 ml de oleo. Pro producer polyarthritis in 100 pro cento del rattos, 0,6 mg de M. butyricum in 0,1 ml de oleo esseva requirite. Fractiones de cera de mycobacterios non induceva arthritis. Ni un deposito de adjuvante ni inflammation a1 sito del injection esseva importante. Polyarthritis se disveloppava mesmo quando le cauda esseva amputate (pro eliminar le deposito del injicite adjuvante) intra 2 horas post le injection. Ben que le mechanismo del induction de polyarthritis per un adjuvante remane incognoscite, il pareva que le occurrentia de morbo articular dependeva de specific sitos de dissemination del adjuvante.


s and presentations related to this grant (penile fibrosis and CVOD) A-2. Ferrini MG, J Moon J, Rivera S, Rajfer J, Gonzalez-Cadavid NF (2009) Genetic Blockade of inducible nitric oxide synthase (iNOS) Intensifies the Development of Fibrosis in a Mouse Model of Diabetes Type 1 Amer Urol Assoc (AUA) Ann Meet, Chicago, IL. Podium Presentation A-3. Ferrini MG, Moon J, Rivera S, Vernet D, Rajfer J, Gonzalez-Cadavid, NF (2009) Antifibrotic and antioxidant therapies prevent the development of fibrosis in the penile corpora cavernosa associated with type 1 diabetes in the iNOS knock out mouse. Amer Urol Assoc (AUA) Ann Meet, Chicago, IL. Podium Presentation A-4. Kovanecz I, Nolazco G, Ferrini MG, Rivera S, Vernet D, Rajfer J, Gonzalez-Cadavid NF (2009) Severe hyperglycemia, renal damage, and low serum testosterone are insufficient in the absence of obesity to cause corporal veno-occlusive dysfunction (CVOD) in a rat model of type 2 diabetes. Amer Urol Assoc (AUA) Ann Meet, Chicago, IL. Podium Presentation A-5. Gonzalez-Cadavid NF (2008) Mechanisms of penile fibrosis. American Urological Association (AUA) Course, 08/20, Baltimore, MD. Invited speaker. A-6. Gonzalez-Cadavid NF. (2009) Novel insights into the pathophysiology and therapy of erectile dysfunction in type 2 diabetes rat models in the context of reno-vascular disease. NIH Meeting for Urological Complications of Diabetes, 03/11, Baltimore, MD. Invited speaker A-7. Gonzalez-Cadavid NF (2009) Role of fibrosis and inflammation in diabetes-related urological disorders. Cedars Sinai Meeting on Fibrosis and Inflammation Research, 03/19, 2009, Los Angeles, CA. Invited speaker A-8. Gonzalez-Cadavid NF (2008) Advances in the understanding of Peyronie's disease at the bench level. Sexual Medicine Society of North America (SMSNA) Ann Meet, 05/18. Orlando, FA. Invited speaker. New applications for funding derived from preliminary results of this grant (penile fibrosis and CVOD)


The semiannual variation of geomagnetic activity has been in the past tentatively explained by two different theories, the so-called equinoctial hypothesis and the axial hypothesis. The latter relates the effect to the inclination of the sun's axis with respect to the sun-earth line, i.e., to the annual variation of the heliographic latitude of the earth. From a reexamination of the data for geomagnetic activity calculated by Bartels (1932, 1940) there is a strong modulation of the amplitude of the semiannual variation during the eleven year period of the solar cycle, which is apparently related to the heliographic latitudes of the sunspot-zones and provides indirect sup port for the axial hypothesis. The amplitude of the modulation is 13% during the increasing phase of solar activity, when the mean sunspot latitude is 20 deg ; it reaches 27% during the late decreasing phase when the mean sunspot latitude is 10 deg . Three axial-symmetric models are derived, which give the statistical distribution of the solar particle flux for three different 3-yr periods during the solar cycle according to mean sunspot-latitudes of 20 deg ,15 deg and 10 deg . The distribution in heliographic latitude is given by two Gaussian functions centered atmore » the heliographic latitudes of the active zones, as defined by the mean latitudes of the sunspots. These models explain the observed semiannual geomagnetic variations, except for a phase-lag of 20 to 30 days. We suggest that a semiannual density variation of charged solar particles which are trapped in the earth's magnetosphere can provide the required phaselag mechanism. This implies a lifetime for these particles of the order of one month. The models can also provide a quantitative explanation of the observed delay of geomagnetic activity behind solar activity during the 11-yr cycle. Furthermore, they are in reasonable agreement with preliminary results on the statistical latitude distribution of comets with ionized tails. A space probe in a heliocentric orbit is proposed in order to obtain further evidence on the latitude distribution of solar particle streams. (auth)« less


The distribution of male cones, female cones, developing cones and mature cones, and hereupon, the ratio of male cones to female cones and the fruit bearing percentage in crown were studied in Zhicheng County of Hubei Province. The number of small female cones on the top of new shoot in early spring was counted. Analysis was made on the relationship between cone crop of a tree and the number of cones in annual sections of the crown and the number of cones in visible crown. It was shown that the number of cones in certain section and the number of visible cones in crown were very informative to the cone crop of a tree. Several ways. including the number of visible cones in crown, the most informative section and the number of immature cones in a tree, were tested to predict cone crop for Masson pine in the county. Joint estimation for regression coefficients of 1991 1993's models were tested. Three stable regression models for cone crop prediction on the basis of female cones, immature cones and mature cones, respectively, were established.


A combination of Photoelectron Spectroscopy and X-ray Emission Spectroscopy has been employed to investigate the buried interface between a Cu(In,Ga)Se 2 thin film solar cell absorber and a CdS buffer layer. The experiments reveal that Na impurities from the sodalimeglass substrate are localized at the buried interface and that intermixing of some of the major constituents occurs. These findings demonstrate a general approach to identify electrically


Extreme drought events and increasing aridity are leading to forest decline and tree mortality, particularly in populations near the limits of the species distribution. Therefore, a better understanding of the growth response to drought and climate change could show the vulnerability of forests and enable predictions of future dieback. In this study, we used a dendrochronological approach to assess the response to drought in natural and planted forests of the maritime pine (Pinus pinaster Aiton) located in its southernmost distribution (south of Spain). In addition, we investigated how environmental variables (climatic and site conditions) and structural factors drive radial growth along the biogeographic and ecological gradients. Our results showed contrasting growth responses to drought of natural and planted stands, but these differences were not significant after repeated drought periods. Additionally, we found differences in the climate–growth relationships when comparing more inland sites (wet previous winter and late spring precipitation) and sites located closer to the coast (early spring precipitation). Response functions emphasized the negative effect of defoliation and drought, expressed as the June standard precipitation-evapotranspiration index calculated for the 12-month temporal scale and the mean temperature in the current February, on growth. The strong relationship between climatic variables and growth enabled acceptable results to be obtained in a modeling approach. The study and characterization of this tree species' response to drought will help to improve the adaptive management of forests under climate change.


The problem of iodine deficiency diseases (IDD) is recognized as relevant due to the significant prevalence of iodine deficiency among the population of many countries of the world, an increase in the incidence of diseases with a wide range of clinical manifestations and a marked tendency to increase the frequency and severity of IDD among children of all age groups We carried out a clinical-anamnestic examination of the child's contingent (187 persons) aged 13–17 years living in an ecologically dependent biogeochemical endemic zone of iodine deficiency, the mountain region of the Zakarpattya region during the period from 2014 to 2015. To identify the pathology of the thyroid gland, a palpatory method of examination was used according to the methodology of the WHO / MRKIDZ, 2001. According to our data 80 pupils (42.8 %) had increased thyroid gland of 1 degree, they were allocated for further and detailed examination and identification of environmentally caused somatic effects. Preventive measures included taking the dietary supplement Yosen, the manufacturer of TOV "OmniFarm", TU U 10.8-35758392-004: 2014 for 6 months. A statistical model for forecasting the dynamics of TSH with supplements with iodine and selenium has been developed. According to our data, the degree of positive changes (decrease of TSH, increase of T4) with supplements with iodine and selenium depends on the starting content of the microelement of iodine in plasma and / or urine: the lower is the initial level of iodine - the more pronounced is the effect of supplements.


It was very important for gas diffusion layer (GDL) of proton exchange membrane fuel cell (PEMFC) to deal well with the channels of water, gas and electron.The carbon paper were teflonated by different PTFE emulsion concentration (12%,15%,18%).The test results by assembling single cell showed that the carbon paper with 15% PTFE had the better electrochemical performance.


Nowadays, in the research field of field-related survey or numerical modeling, data post-processing is often completed using of the third-party softwares, which may have difficult on the storage and management of the large amount of data and figures. A convenient way is needed to process the field data. In this paper, ArcGIS is utilized to realize visualization of the tidal current computed from the hydrodynamic model of Caofeidian sea area. In virtue of the interface of ArcGIS and the numerical model, the changes of flow field of the study area before and after the project are shown clearly and friendly, which provides great help and convenience for the data analysis.


The mangroves play a vital role in the ecological balance. They provide marine ecosystem resources and are involved in its stabilization and in the coastal protection. They constitute the growth areas of many species that feed marine species and particularly shrimp. We develop a standard (cid:133)shery model by integrating mangroves area into the analysis. The extended model shows that mangrove plays an important role in shrimp production and data related to it are well supported by the model. We analyze the e⁄ects of mangrove on open access of the French Guiana shrimp (cid:133)shery and show that mangrove is not the only factor that plays a vital role in the French Guiana shrimp (cid:133)shery.


This paper deals with the existence and uniqueness results for the solution of a Neutral fractional integro-differential problem with nonlocal conditions. Using the Nonlinear alternative for single valued maps, Krasnoselskii's and Banach fixed point theorems to proof our main results. An example is given to illustrate our main results.


Aspect-Oriented Programming (AOP) has remained a controversial idea, for over decade. Its main objective is to improve the software development process and separate concerns using aspects. In this paper, AOP is compared to OOP. Both methodologies have their relative strengths and weaknesses that may influence the function of certain systems, in different ways. There are theoretical, implementation and complexity differences between AOP and OOP. In order to illustrate the effectiveness of AspectJ, the AspectJ tutorial is included in this report.


Electronically steerable passive array radiator (ESPAR) antennas are proposed for low-cost analog adaptive beamforming. The configuration and design of these antennas and some simulation results, especially on their beam/null steering capability, are presented. From the results of a numerical analysis, it was found that 5-element ESPAR antennas can offer a beam gain of 9 dBi/spl plusmn/1 dB and a null deeper than -50 dBi in an arbitrary direction. In this case, the beam gain and null were obtained separately. It was also found that 7-element ESPAR antennas can achieve continuous steering in almost all directions, with a simultaneous 8 dBi beam gain and 30 dBi null, excluding the region where the direction of the beam and the direction of the null are within about 45-degrees however 5-element ESPAR antennas are unable to achieve steering in a number of directions, even with a simultaneous 5 dBi beam gain and -15 dBi null.


In order to develop WAP function efficiently in a handset,We adopted model device based on the background of a CDMA IX handset and developed WAP emulator which ran on the Windows Operating System.The WAP emulator integrated the WAP client successfully and adopted the technique of multithread,windows socked,transporting command in a queue and file storage,making it convenient to transplant the source code from the lab to windows.It was proved that the emulator simulated the WAP development lab environment successfully and increased the developing efficiency.


Received: 26 February 2018 Accepted: 11 June 2018 Air-source and ground coupled heat pumps are depicted as energy efficient systems. Nevertheless, the ground coupling incurs in expensive extra-costs owing to the ground heat exchangers (GHEs), whereas the air exploitation suffers lower temperatures and frosting conditions. Coupling both solutions in a dual-source heat pump system (DSHP) can mitigate the former drawbacks. The present paper analyses the performance of a DSHP experimental prototype, installed as the air-conditioning system of a testing room at the University of Ferrara, Italy. The prototype is composed by a common air-to-air heat pump and a geothermal closed loop. The refrigerant circuit of the heat pump has been modified to couple on demand the closed loop by means of a plate heat exchanger. As GHE type, the Flat-Panel solution has been chosen due to its higher performance respect to all other horizontal and shallow exchangers. The switching between air and ground is automatized by mean of a control unit, according to the best thermal conditions, and the closed loop is also partializable to evaluate the length impact on the switching rules. The DSHP flexibility has allowed better performance than the original air-to-air heat pump, especially under hard weather conditions, and therefore an overall energy saving.


According as the development of information technology and service industry, the change of industrial structure and the trend of labor-market's flexibility, the number of contract laborers is rising steadily. They are facing the poor working conditions and insecurity about their jobs, but yet they have not been recognised as the employee by the court and have been excluding from the legal protections because of the negative attitude of the court. Many researchers and experts in labor law, and the labor agitators have emphasized that the legal protections and measures should be taken at their labor or service relations for one employer. For example, to impose a written contract, to protect or guarantee the payment of wages, to prohibit the unfair dismissal, to participate in the social security programs as such workmen's accident compensation insurance and employment insurance, and so on. But it's very hard to legislate in detail for protecting the diverse working conditions of the contract laborers, because the extent of economical dependency and workings conditions are very diverse. Consequently, the alternative measures are required that the fundamental labor rights such as the right to organize, the right to bargain collectively and the right to take concerted action should be guaranteed them constitutionally so that they should protect ourselves concretely or appropriately the working conditions and job security by the collective bargaining and agreements.


This article is Part 9 of the author's linear elastic glucose behavior study, which focuses on searching for an applicable data range of two glucose coefficients of both GH.f-modules and GH.p-modules via lower bound and upper bounds of predicted postprandial plasma glucose (PPG) values which would be useful to most type 2 diabetes (T2D) patients. The linear elastic glucose behavior equation is: Predicted PPG = (0.97 * GH.f-modulus * Weight) + (GH.p-modulus * Carbs&sugar) - (post-meal walking k-steps * 5) This equation is useful in predicting PPG values and helping patients with their diabetes control. Here is the step-by-step PPG boundary analysis of the eight standard cases using linear elastic glucose theory as described in this paper [10, 17]: 1. Baseline PPG has only two values, i.e. using lower bound of FPG 100*0.97 = 97, and upper bound of FPG 150*0.97 =146 2. plus carbs/sugar intake amount's lower bound of 10 grams of carbs/sugar intake: 97+10*GH.p 2.0 = 97+20 = 117 mg/dL, and higher bound of 25 grams of carbs/sugar intake: 146 + 25*6.0 = 146+150 = 296 mg/dL 3. minus post-meal walking k-steps' lower bound of 4K steps: -5*4 = - 20 = 117-20 =97 mg/dL, and higher bound of 1K steps: -5*1 = -5 = 296-5 = 291 mg/dL 4. Therefore, the boundary of predicted PPG shows data is located within the numerical range of lower bound of 97 mg/dL & upper bound of 291 mg/dL.


Lima, the capital of Peru, has not suffered from a great earthquake since 1746, making this a prone Mw 8.8 earthquake area according to seismological studies. In this context, seismic structural health monitoring presents an opportunity to assess rapidly buildings after a great earthquake and protect inhabitant from those buildings with high risk of collapse due to aftershocks. A basic seismic structural health monitoring arrangement of a fifteenth-floor residential building is presented using a low-cost sensor called Raspberry Shake 4D. The implemented sensor incorporates both a vertical velocity geophone and three orthogonally positioned microelectromechanical systems accelerometers. The building is a reinforced concrete shear walls structure located in Comas, north of Lima. More than thirty seismic events have been recorded, including the Mw 8.0 Lagunas earthquake (05/26/2019) and the Mw 5.8 (22/06/2021) with epicentral distances of 709 km and 94 km, respectively. Acceleration as high as 150 cm/s2 and as low as 2 cm/s2 have been recorded. It was possible to obtain fundamental frequencies of vibration in longitudinal and transversal directions of the building from the response calculated using the wavelet transform that have a good agreement with results of microtremor measurements performed at different floors. The computed scalograms for seismic records showed important values of energy amplitudes for the fundamental frequencies of the building. Finally, theoretical fundamental frequencies were obtained from a 3D finite element model and an elastic analysis.


One of the most interesting signs of change in the American political socialization process has been the movement of some questions from the status of "nonissues"-questions so highly consensual that they do not appear to be political issues at all (see Weissberg, 1976: 124)-to positions marked by considerable disagreement among preadults. Such change in the content of political orientations provides an ideal setting for investigating the dynamics of political learning.


Discussing female poetry in the 80's~90's, besides explaining its extention with the connecting link between the preceding and the following, the paper hopes to reveal the three phases and feature of the female portry in the 80's-90' s with the unity of the opposites. Its aim is to solve the series problems in showing the main sequence and reading the history again.


This is the second part of a two-part paper on optimal design of limited feedback single-user and multius er spatial multiplexing systems. The first part of the paper studies the single-user system and this part addresses the multiuse r case. The problem is cast in form of minimizing the average transmission power at the base station subject to the outage probability constraints at the users' side. The optimization is over the power control function at the base station as well as the users' channel quantization codebooks. The base statio n has M antennas and servesM single-antenna users, which share a common feedback link with a total rate ofB bits per fading block. We first fix the quantization codebooks and study the optimal power control problem which leads to an upper bound for the average transmission sum power. The upper bound solution is then used to optimize the quantization codebooks and to deri ve the optimal bit allocation laws in the asymptotic regime of B → ∞. The paper shows that for channels in the real space, the optimal number of channel direction quantization bits should be M − 1 times the number of channel magnitude quantization bits. It is shown that the users with higher requested QoS (lower target outage probabilities) and higher requested downlink rates (higher target SINR's) should receive larger shares o f the feedback rate. The paper further shows that, for the target QoS parameters to be feasible, the total feedback bandwidth sho uld scale logarithmically with γ̄, the geometric mean of the target SINR values, and1/q̄, the geometric mean of the inverse target outage probabilities. Moreover, the minimum required feedback rate increases if the users' target parameters deviate fromthe average parameters̄γ and q̄. Finally, we show that, asB increases, the multiuser system performance approaches the performan ce of the perfect channel state information system as1/q̄ · 2− B M2 .


This paper presents algorithms for three-dimensional tracking of surgical needles using the stereo endoscopic camera images obtained from the da Vinci® Surgical Robotic System. The proposed method employs Bayesian state estimation, computer vision techniques, and robot kinematics. A virtual needle rendering procedure is implemented to create simulated images of the surgical needle under the da Vinci ® robot endoscope, which makes it possible to measure the similarity between the rendered needle image and the real needle. A particle filter algorithm using the mentioned techniques is then used for tracking the surgical needle. The performance of the tracking is experimentally evaluated using an actual da Vinci® surgical robotic system and quantitatively validated in a ROS/Gazebo simulation thereof.


Despite that aircraft positions and movements can be easily monitored on the radar displays at major airports nowadays, it is still important for the air traffic control tower (ATCT) controllers to look outside the window as much as possible to assure safe operations of traffic management. The present paper investigates whether an introduction of the NASA's proposed Spot and Runway Departure Advisor (SARDA), a decision support tool for the ATCT controller, would increase or decrease the controllers' head-up time. SARDA provides the controller departure-release schedule advisories, i.e., when to release each departure aircraft in order to minimize individual aircraft's fuel consumption on taxiways and simultaneously maximize the overall runway throughput. The SARDA advisories were presented on electronic flight strips (EFS). To investigate effects on the head-up time, a human-in-the-loop simulation experiment with two retired ATCT controller participants was conducted in a high-fidelity ATCT cab simulator with 360-degree computer-generated out-the-window view. Each controller participant wore a wearable video camera on a side of their head with the camera facing forward. The video data were later used to calculate their line of sight at each moment and eventually identify their head-up times. Four sessions were run with the SARDA advisories, and four sessions were run without (baseline). Traffic-load levels were varied in each session. The same set of user interface - EFS and the radar displays - were used in both the advisory and baseline sessions to make them directly comparable. The paper reports the findings and discusses their implications.


Obtained two formulae of Riccati equationz′=z2-a(x)z +b(x) under some conditions.By these formulae which related only witha(x) andb(x) of Riccati equation coefficient,the process of solving Riccati equation is very simple.


3,3-Dimethylcyclopentanes (neopentylenes) are ubiquitous in Nature but largely absent from synthetic pharmaceutical libraries. Neopentylenes define a hydrophobic and rigid 3-D topology with distinct molecular pharmacology, as exemplified here with two neopentylene-fused analogues of the synthetic anti-inflammatory drug, ibuprofen.


Talking on the phone is usually a private activity, but it becomes a public activity when using a cellphone in certain spaces. Unlike a traditional payphone in public, cellphones do not have privacy booths. Therefore, the ways in which people respond to cellphone calls in public spaces provide markers for social topographical space. In this study I explore how cellphone users negotiate privacy when using cellphones in public space and how those within the proximity of the caller negotiate space in response to these callers. Based on a year-long study involving observation fieldwork and in-depth interviews, I discuss the flexibility with which people constantly negotiate their private and public sense of self when using and responding to cellphones in public spaces.


The effect of pumicing on the in vivo use of a resin modified glass poly(alkenoate) cement and a conventional no-mix composite for bonding orthodontic brackets


SAY Primary Teeth Statement Necessary X-rays Schedule is filled Confirm or verify Change in schedule Consultation or discussion about your care Fee Examination Reserved late morning for you Restoration or rehabilitation Agreement Invest Bookkeeper's courtesy Doctor is with a patient Prepare Inform Restorations Payment arrangements or payment schedule Paperwork Necessary X-rays Reshape or re-contour The assistants or coordinators Improved "Our financial coordinator handles our payment schedule" Former patient/patient of record Cash basis with our laboratory Treatment room Dentures Discomfort Take care of Fees Removed Hygiene appointment; recare Complete dentistry Interrupted schedule Try in Approve, authorize, OK Empty your mouth Diagnostic models Recommend Sedative dressing Reception room Could you please hold? Do you prefer Monday at 10 or Wednesday at 3:00? How may I help you? Dental care; treatment INSTEAD OF Baby Teeth Bill Bite wings Booked up Call to remind Cancellation Case presentation Charge Check up Come at 11AM Completely rework Contract Cost Discount Doctor is busy Drill Educate patient Fillings Financial policy Forms Full mouth x-rays Grind The girls New "No problems. We can arrange something," says Dr. Doe. Old patient One half down Operatory Plates Pain Pay for Prices Pulled Recall Reconstruction Running late Seating Sign Spit Study models Suggest Temporary filling Waiting room Wait a minute When would you like to come?


Inspired by a recently proposed GUT model based on the trinification ($\mathrm{SU}(3)^3$) gauge group with a global family ($\mathrm{SU}(3)_F$) symmetry, we consider an effective low-energy three Higgs doublet model that may shed light on what underlies the observed fermion mass hierarchies and CKM mixing. We discuss possibilities for charged scalars coming from this model to show in collider experiments and show some interesting benchmark points.


Introduction:
 Vascular remodeling is associated with target organ damage and fatal cardiovascular events. The molecular mechanisms that control vascular remodeling are still poorly understood, limiting effective therapeutic approaches. The β-catenin C-terminal domain is required in smooth muscle cells (SMCs) for artery formation during embryogenesis, but its role in vascular remodeling in adulthood is unknown. Therefore, the objective of this study was to define the importance of β-catenin C-terminal domain in SMCs during vascular remodeling.

 Hypothesis:
 β-catenin C-terminal signaling is required for neointima formation after vascular injury.

 Methods:
 We studied male and female mice expressing a C-terminus-deficient β-catenin specific to SMCs (SMβCΔC mice). Mouse aortic SMCs (MASMCs) were isolated from SMβCΔC mice (βCΔC MASMCs). Results are shown as mean ± SEM.

 Results:
 SMβCΔC mice show reduced neointima formation (males: WT 100±17 vs SMβCΔC 30±9; females: WT 100±19 vs SMβCΔC 30±7; n=10; P<0.05) and decreased SMC proliferation (males: WT 100±6.8 vs SMβCΔC 22±5.9; females: WT 100±9.9 vs SMβCΔC 34±9.0; n=5; P<0.05) after arterial injury. RNA-seq analysis revealed a downregulation of the sphingosine-1-phosphate receptor 1 (S1pr1) transcript in βCΔC MASMCs. We further found that β-catenin interacts with the S1pr1 promoter (Cut&Run assay, IgG Control 1.00±0.06 vs β-catenin 2.82±0.50; n=4; P<0.05) and acts through its C-terminal domain to activate S1pr1 transcription (luciferase reporter assay, vector Control 100.0±17.08 vs βCΔC 19.9±5.8; n=6; P<0.05) and protein expression (Control 0.95±0.20 vs βCΔC 0.08±0.02; n=4; P<0.05). Consistent with these observations, S1PR1 expression was decreased in SMCs of arteries from SMβCΔC mice (WT 100±6.9 vs SMβCΔC 8±2.1; n=5; P<0.05), and re-establishing SMC S1PR1 expression rescued neointima formation (SMβCΔC 0.15±0.02 vs SMβCΔC;S1PR1Gain-of-function 0.93±0.11; n=8; P<0.05).

 Conclusion:
 Our findings identify β-catenin C-terminal output as a novel upstream regulator of S1PR1 expression and define an essential β-catenin/S1PR1 axis that drives neointima formation after injury. Targeting this axis could provide a therapeutic strategy to reduce vascular remodeling and cardiovascular disease.


Encapsulates are, in general, the passive components of any photovoltaic device that provides the required shielding from the externally stimulated degradation. Here we provide comprehensive physical insight depicting a rather non-trivial active nature, in contrast to the supposedly passive, atomic layer deposition (ALD) grown Al2O3 encapsulate layer on the hybrid perovskite [(FA0.83MA0.17)0.95Cs0.05PbI2.5Br0.5] photovoltaic device having the configuration: glass/FTO/SnO2/perovskite/spiro-OMeTAD/Au/(±) Al2O3. By combining various electrical characterization techniques, our experimental observations indicate that the ALD chemistry produces considerable enhancement of the electronic conductivity of the spiro-OMeTAD hole transport medium (HTM), resulting in electronic modification of the perovskite/HTM interface. Subsequently, the modified interface provides better hole extraction and lesser ionic accumulation at the interface, resulting in a significant lowering of the burn-in decay and nearly unchanged charge transport parameters explicitly under the course of continuous operation. Unlike the unencapsulated device, the modified electronic structure in the Al2O3 coated device is essentially the principal reason for better performance stability. Data presented in this communication suggest that the ionic accumulation at the spiro-OMeTAD/perovskite interface triggers the device degradation in the uncoated devices, which is eventually followed by material degradation, which can be avoided by active encapsulation.


In this thesis we discuss some aspects of the design of a system of systolic arrays, from the VLSI layout level to the system level.
First, we discuss 3-D VLSI layout, where tighter lower and upper bounds for the volume and maximum wire length for the layout of the different families of graphs in a 3-D environment were developed. Except in two cases, all the bounds for the volume are optimal. The first case is the one-active-layer layout of the planar graphs, the other is the unrestricted layout for graphs with separators N$\sp{\rm q}$, q = 2/3. A cost model for reflecting the real cost of the layout, instead of taking the volume as a measure of cost, was also developed.
In Chapter 3, we develop a methodology for designing a systolic array starting from recurrence equations. The idea of Control Flow Systolic Arrays to handle uniform, as well as nonuniform recurrence equations, is developed. This methodology is basically a search for a heuristic solution in the space of all the possible solutions. Because of the unlimited search space, the search process must be guided for the search to be completed in a reasonable amount of time.
Chapter 4 introduces the idea of converting the data between two systolic arrays that were directly interfaced, instead of using a common memory which would be a bottleneck for the whole system. The minimum number of buffers required to convert the data between two given distributions was also calculated, a general purpose converter was also proposed.


The last decade of this millennium is testimony to changing times for the people and forests of the Hindu Kush-Himalayas, and it has seen the emergence of people-centred forest policies in almost all the countries in the region.


The purpose of this 2-part study was to explore the mathematical and purchasing competencies present in students' engagement in shopping practices in a low-income African American neighborhood. Study 1 consisted of in situ analyses of children's shopping activities at a local store, revealing the variety of arithmetic tasks that emerged in relation to varied artifacts, shopping routines, social norms, and clerk support. In an effort to reveal competencies that could not be measured through observation alone, Study 2 consisted of individual interviews of 30 first and second graders about tasks that required them to purchase items at a mock store. Analyses revealed both strategies that were frequently and infrequently associated with successful purchasing and the relationship between children's strategy choices and the demands of particular purchases. This research documents the many mathematical competencies children present that may not be captured in traditional school assessments and considers how this prior knowledge might be used to inform instruction and treatments of sociocultural frameworks.


Due to its simple structure and relaxed requirements for radio frequency (RF) filtering, the so called direct-conversion or zero-IF architecture is gaining more and more interest in radio receiver design. One practical problem in the analog I/Q processing section is the amplitude and phase matching of the I and Q signal branches. With reasonable design and implementation costs, amplitude and phase mismatches in the order of 1-5% and 1-5/spl deg/ are feasible. The performance degradation due to these levels of I/Q mismatches is, however, considerable, especially in case of OFDM signals, where the mismatches cause certain type of intercarrier interference (ICI). In this paper, a novel structure for I/Q mismatch compensation is proposed for OFDM systems. The proposed compensator operates in the time domain and is based on adaptive I/Q decorrelation. It has low computational complexity and is basically independent of other receiver and system related nonidealities, especially frequency offsets and multipath propagation. Furthermore, the compensator is blind in the sense that no known training signals are needed. The effectiveness of the proposed structure is illustrated using computer simulations, showing impressive performance in practical signaling environments.


It becomes excessively challenging or even impossible to capture, share and accurately reproduce experimental results in computer engineering for fair and trustable evaluation and future improvement. This is often due to ever rising complexity of the design, analysis and optimization of computer systems, increasing number of ad-hoc tools, interfaces and techniques, lack of a common experimental methodology, and lack of simple and unified mechanisms, tools and repositories to preserve and exchange knowledge apart from numerous publications where reproducibility is often not even considered. This ACM SIGPLAN workshop is intended to become an interdisciplinary forum for academic and industrial researchers, practitioners and developers in computer engineering to discuss challenges, ideas, experience, trustable and reproducible research methodologies, practical techniques, tools and repositories to:

•capture, preserve, formalize, systematize, exchange and improve knowledge and experimental results including negative ones

•describe and catalog whole experimental setups with all related material including algorithms, benchmarks, codelets, datasets, tools, models and any other artifact

•validate and verify experimental results by the community

•develop common research interfaces for existing or new tools

•develop common experimental frameworks and repositories

•share rare hardware and computational resources for experimental validation

•deal with variability and rising amount of experimental data using statistical analysis, data mining, predictive modeling and other techniques

•implement previously published experimental scenarios (auto-tuning, run-time adaptation) using common infrastructure

•discuss new publication models for effective methods of incorporating experimental methodologies and data including addressing associated licensing and intellectual property concerns

•improve reviewing and evaluation process for publications and shared artifacts

•enable interactive articles


The evolution of nanotechnology and the production of nanomedicine from various sources had proven to be of intense value in the field of biomedicine. The smaller size of nanoparticles is gaining importance in research for the treatment of various diseases. Moreover the production of nanoparticles is eco-friendly and cost effective In the present study, amalgamation of silver nanoparticles (AgNPs) or (Green-Silver) has been exhibited utilizing concentrates ofCinnamomum verum diminishing fluid silver nitrate. The AgNPs were characterized by Ultraviolet-Visible (UV-vis) Spectrometer. The reaction process was simple for formation of silver nanoparticles. This work proved the capability of using biomaterial towards the synthesis of silver nanoparticle and  effectiveness of animicrobial properties.


The aim of this study was to determine the effect of pumpkin and flaxseed oils on the fatty acid profile and nutrient changes in table eggs. At 38 weeks of age, Lohmann Brown Lite hens were divided into three groups depending up the diet. The birds were housed in individual cages (6 hens per cage) with a space allowance of 943.2 cm2 per hen, and given diet standard complete feed mixture for laying hens. Hens from experimental groups were fed with complete feed mixtures supplemented by pumpkin (group E1) or flaxseed (group E2) oils at a dosage of 3%. The experiment lasted 52 days. In the last week of the trial, the eggs were collected for chemical analysis. Twelve eggs from each dietary treatment were randomly selected and analysed. Significant differences between control and group E1 in the content of crude protein (P ˂ 0.05), between both experimental groups (E1 and E2) in the content of ash (P ˂ 0.01) in yolk, and between control and the experimental groups in the content of dry matter (P ˂ 0.05) in albumen were detected. Significant (P ˂ 0.01) differences were found in contents of myristic, palmitic, heptadecanoic, oleic, linoleic, and cis-11,14-eicosadienoic acids between control and experimental groups E1 and E2. Compared to control, higher (P ˂ 0.01) concentrations of monounsaturated fatty acids, lower concentrations of saturated fatty acids and also lower contents of polyunsaturated fatty acids in the experimental groups were observed. The supplementation of flaxseed oil had a positive effect on the content of n-3 α-linolenic acid. Albumen, laying hens, nutrients, plant fats, yolk Dietary fat type and fatty acid (FA) composition of consumed fats are more important than the amount of dietary consumed cholesterol (Simopoulos 2000). Lipids contribute to approximately 65% of the dry matter content of egg yolk (Anton 2007). It has been reported that the pure components of essential oils inhibit hepatic 3-hydroxy-3methylglutaryl coenzyme A (HMGCoA) reductase activity which is a key regulatory enzyme in cholesterol synthesis (Crowell 1999). Animal organism cannot create essential fatty acids and for its correct functioning, these acids must be received in the diet (Chow 2008). The results of many studies have confirmed that saturated fatty acids and trans fatty acids have negative effects on human health, whereas polyunsaturated fatty acids have a positive effect on human health as regards the coronary heart disease (Erkkila et al. 2003). Pumpkin seeds contain L-tryptophan, n-6 and n-3 fatty acids and a very high concentration of vitamin E (Hashemi 2013). Pumpkin seed oil has become a recognized source of phenolic compounds (Andjelkovic et al. 2010). Flaxseed oil contains high levels of polyunsaturated fatty acids and these compounds have been reported to reduce the incidence of heart disease and cancer in humans (Zhao et al. 2007). Changes in lipid metabolism in various animals were achieved by the addition of various additives to the diet (Capcarova et al. 2011; Emrichová et al. 2013; Petruška et al. 2013; Zbyňovská et al. 2014). The aim of this study was to determine the effect of pumpkin and flaxseed oils on the fatty acid profile and nutrient changes in table eggs. ACTA VET. BRNO 2016, 85: 277-283; doi:10.2754/avb201685030277 Address for correspondence: Branislav Gálik Slovak University of Agriculture in Nitra Tr. A. Hlinku 2, 949 76, Nitra, Slovakia Phone: +421 376 414 331 E-mail: firstname.lastname@example.com http://actavet.vfu.cz/ Materials and Methods Animals and housing At 38 weeks of age, Lohmann Brown Lite hens were housed in three-floor cages (six hens in one cage; with a space allowance of 943.2 cm2 per hen), divided into three dietary of groups (C control, E1 pumpkin oil, E2 flaxseed oil). A total of 18 hens were monitored. During the experiment, the light regime was set at 16 h. The experiment lasted 52 days. The laying hens were kept in standard bioclimatic and welfare conditions. In this animal study, institutional and national guidelines for the care and use of animals were followed, and all experimental procedures involving animals were approved by the ethics committee. All efforts were made to minimize the animals' suffering. Feeding In the control group hens were fed a standard complete feed mixture for laying hens; in the experimental groups hens were fed feed mixtures supplemented by pumpkin (E1) or flaxseed (E2) oils at a concentration of 3%. Pure by the origin and virgin oils (mechanically pressed by cold technology) were used in the experiment. Vitamin E (0.1 g per 1 kg of feed) was added into feed mixture in the experimental groups. Laying hens in all groups received drinking water and feed mixture ad libitum. Feeding mixture was composed of wheat, corn, soybean meal, rapeseed meal, sunflower meal, animal fat, soybean oil, calcium carbonate, feed additives, sodium bicarbonate, monocalcium phosphate, sodium chloride and enzyme complex of phytase. The fatty acid profile of oils is shown in Table 1 and the nutrient composition of feed mixtures after addition of oils is presented in Table 2. Sampling and laboratory analysis During the last week of the trial the eggs were collected for chemical analysis. Twelve eggs from each dietary group were randomly selected and analysed. Nutrient composition of diets and eggs were determined by standard laboratory methods and procedures (AOAC 2000) in the Laboratory of Quality and Nutritive Value of Feeds (Department of Animal Nutrition, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Slovak Republic). The content of crude fat was determined by extraction and gravimetric method according to the Soxhlet principle. The sample in the analytic tube was dried for 278 Table 1. Fatty acid profile of oils. Fatty acid Flaxseed oil Pumpkin oil % of crude fat Myristic 0 0.11 Palmitic 5.59 11.13 Palmitoleic 0.08 0.12 Heptadecanoic 0.03 0 Stearic 4.61 6.19 Oleic 18.95 38.87 Linoleic 31.38 41.37 α-linolenic 37.63 0.17 Arachidic 0.15 0.45 Cis-11-eicosenoic 0.13 0.12 Behenic 0.14 0.14 Lignoceric 0.23 0.09 Ratio Σn3/Σn6 1.2 0 Ratio Σn6/Σn3 0.83 248.04 Table 2. Nutrient composition of feed mixtures for experimental groups. Nutritive Unit C E1 E2 Dry matter % 91.12 90.88 91.4 Crude protein % of DM 17.68 17.81 17.45 Fat % of DM 6.53 7.61 7.59 Fiber % of DM 4.09 3.71 3.78 Ash % of DM 12.01 11.49 11.26 NFE % of DM 50.81 50.26 51.32 Organic matter % of DM 79.11 79.39 80.14 Starch % of DM 35.3 35.62 35.45 Sugar % of DM 3.9 3.84 3.94 NFE nitrogen free extract, DM dry matter 30 min at 100 °C. After drying, cooling and weighing, petroleum extract was added and the sample was extracted for 60 min at 40–65 °C on the apparatus Soxtec System HT 1043 Extraction Unit (Tecator, Sweden). For the characteristics of lipid fraction, triglycerides were hydrolyzed to glycerol and free fatty acids. Fatty acids were then derivative to methylesters. After their preparation, acids were separated on the basis of carbon number and level of unsaturation by gas chromatography fitted with a flame-ionization detector (FID). For the identification column 37 components mixture (Supleco 47885-U) was used. Standard solution was diluted with 10 ml of hexane, 1 ml supplementation of 2 N potassium hydroxide in methanol. The analytic tube was heated for 30 s at 60 °C in a water bath. After 1 min, 2 ml of 1 N hydrochloric acid were added. The top layer was transferred at the amount of 2 ml to an autosampler vial with ninhydrin. Injection of samples was performed by injection autosampler Agilent. The content of fatty acids as a percentage in crude fat was determined on the machine Agilent 6890A GC (Agilent Technologies, USA). Statistical analysis The data used for statistical evaluation of nutrients represent means of values obtained from 12 eggs from each group. Differences between groups were analyzed with one-way analysis of variance (ANOVA) by using the statistical programme IBM SPSS 20.0. Results were evaluated using Tukey test. Values with different superscripts within a column or row are significant (abat P < 0.05, AB at P < 0.01). Relationships between nutrients were assessed on the base Pearson correlation coefficient.


The design of new biomass-fired power plants with increased steam temperature raises concerns of high-temperature corrosion. The high potassium and chlorine contents in many biomasses, specially in wheat straw, are potentially harmful elements with regard to corrosion. Chlorine may cause accelerated corrosion resulting in increased oxidation, metal wastage, internal attack, void formations, and loose non-adherent scales. The most severe corrosion problems in biomass-fired systems are expected to occur due to Cl-rich deposits formed on superheater tubes. In the first part of this revision the corrosion mechanism proposed are described in function of the conditions and compounds involved. The second part is focused on the behaviour of the materials tested so far in the boiler and in the laboratory. First the traditional commercial alloys are studied and secondly the new alloys and the coatings


Partial multi-label learning (PML) aims at learning a robust multi-label classifier by training on ambiguous data, where each sample is associated with a set of candidate labels, among which only a subset are valid labels. A basic premise of existing PML solutions is to obtain enough partial multi-label samples for inducing the classification model. However, when dealing with new tasks, we may only have a few PML samples for those tasks. Furthermore, existing few-shot learning approaches assume the support (training) samples are precisely labeled; as such, irrelevant labels in the candidate label set may seriously mislead the meta-learner and thus result in a compromised performance. How to achieve PML with limited few-shot support samples is an important and practical problem, but not yet well studied. In this paper, we propose an approach called FsPML (Few-shot PML) to tackle this problem. Specifically, FsPML first performs adaptive distance metric learning via an embedding network using both sample features and label semantics in the embedding space. Next it rectifies the positive and negative prototypes of each new label of the target task in the embedding space. An unseen example can then be classified via its distances to the positive and to the negative prototypes. Experimental results on widely-used multi-label datasets (MS COCO and NUS-WIDE) demonstrate that our FsPML outperforms competitive baselines across different settings, and it can quickly generalize to new tasks with fewer training samples.


One of the first cities, Anuradhapura (377 BCE–1017CE) remains a world heritage site in Sri Lanka. Apart from the great Buddhist architectural edifices, agriculture landscape significant in this city is apparent in creating a Buddhist sacred landscape: large water tanks, paddy fields, and canal systems are an essential part of the city landscape and the social/cultural system. This research examines how and why these large water tanks and paddy fields are incorporated in the ancient city concept to achieve a Buddhist sacred place, thus a sustainable city and society. The research examines the ancient city concepts and evaluates Anuradhapura city through different time periods, focusing on the agricultural landscape, Buddhist sacred city, and everyday life performances around these. The research methodology synthesises aspects of phenomenology, anthropo-ethnography, landscape analysis, Buddhist philosophy, and historical analysis. In Anuradhapura sacred city, the everyday life of people has been bounded around large water tanks and vast paddy fields for the maintenance of the city as well as to achieve sacred experiences by engaging with sacred natural landscape elements through everyday performing and dwelling in the city. Thus, urban agriculture acts as a mechanism of engaging the everyday life of the people with the landscape and uplift the nature of the humans and human wellbeing, hence establishes a healthy city, while enhancing the city form and the Buddhist sacred


The telechelic macromonomer cross-linkable stabilizer (TMCS) was synthesized by the reaction of isocyanate-terminated prepolymer with methacrylamide and was successfully employed as a steric stabilizer and possible cross-linking agent in the dispersion polymerization of styrene. The urethane and methyl groups in TMCS are found in the spectrum of PS microspheres, and the reactive double bonds in TMCS disappear after polymerization with styrene. The qualitative analysis reveals that the symmetric molecular structure with vinyl group in TMCS takes part in the reaction with styrene, and it is proposed that the PS microspheres are substantially cross-linked. In reality, for the 100 wt % TMCS system, the PS is not totally soluble in THF, remaining as a translucent fully-swollen gel in THF. Thus, these qualitative structural investigations suggest that the TMCS serves as a reactive stabilizer as well as a cross-linking agent.


The pursuit of a healthier life has created life style changes through exercise; in addition, an athleisure look as well as a combination of everyday clothes and sportswear has rapidly spread through sharing based on imagebased SNS. Fashion related images shown in an image-based SNS are considered important resources for grasping micro-needs with regard to the sensibility of consumers. Therefore, this study analyzes the design characteristics of an athleisure look shown in image-based SNS. In order to analyze the athleisure look, images of the entire garment were collected and classified to enable content analysis methods that analyzed the design characteristics of each type. As a result, types were classified as sporty-athleisure, modern-athleisure, high-end athleisure, retro-athleisure, and romantic-athleisure. Looking at the characteristics of the athleisure look, it was shown that the design characteristics of each type were well expressed through differences in the direction, material, and details by matching between the items used. This study can be used in design development processes by deriving the characteristics of athleisure looks through an analysis of fashion images that appear in image-based SNS.


Sorghum, Sorghum bicolor (L.) Moench, is the world's fifth most important cereal crop, cultivated on about 45 million hectares for food, feed, beverage, and fodder. The most significant technological change since the 1960s has been the development and use of F1 hybrid seed (14), which has lead to a dramatic
improvement in the crop's productivity. Sorghum cultivation in intensive, commercialized systems where yields average 3 to 5 t ha-1 relies almost totally on hybrid seed. In contrast, yields vary widely and average less than 1 t ha-1 in low-input production systems.


The ceramide hydrolysis by lysosomal acid ceramidase (AC) has been reported to regulate lysosome function, which determines the degradation of multivesicular bodies. In this regard, we found that urinary exosome excretion was remarkably increased in podocyte‐specific AC gene knockout (Asah1fl/fl/Podocre) mice. Given the importance of transient receptor potential mucolipin 1 (TRPML1) channel‐mediated Ca2+ release to lysosome function and its regulation by sphingolipids, the present study tested a hypothesis that podocyte‐specific Asah1 gene deletion inhibits TRPML1 channel activity, leading to lysosome dysfunction and exosome release from podocytes. It was found that exosomes released from Asah1fl/fl/Podocre podocytes were remarkably higher than WT/WT podocytes as detected by nanoparticle tracking analysis. Super‐resolution microscopy showed less fusion of multivesicular bodies and lysosomes in Asah1fl/fl/Podocre podocytes compared with WT/WT podocytes. Using GCaMP3 Ca2+ imaging, it was found that ML‐SA1 as a specific cell‐permeable TRPML1 inducer remarkably increased Ca2+ release from lysosomes by 7.35 folds in WT/WT podocytes. Pre‐treatment of podocytes with carmofur, a specific AC inhibitor almost totally blocked ML‐SA1‐induced Ca2+ release in WT/WT podocytes. In Asah1fl/fl/Podocre podocytes, however, ML‐SA1 was found to have no effects on TRPML1 channel‐mediated Ca2+ release, but sphingosine as an AC product of ceramide hydrolysis remarkably increased TRPML1 channel‐mediated Ca2+ release in both WT/WT podocytes (5.42 folds) and Asah1fl/fl/Podocre podocytes (4.52 folds). Using whole‐lysosome patch clamp recording, we detected ML‐SA1‐induced Ca2+ currents in a dose‐dependent manner through the membrane of lysosomes isolated from WT/WT podocytes. Compared to WT/WT podocytes, intact lysosomes isolated from Asah1fl/fl/Podocre podocytes had evidently blunted opening of TRPML1 channels in response to its agonist, ML‐SA1. AC associated sphingolipids, sphingomyelin, ceramide and sphingosine had different effects on TRPML1 channel activity in WT/WT podocytes, with inhibition by sphingomyelin, no effect from ceramide, but enhancement by sphingosine (2.25 folds). In Asah1fl/fl/Podocre podocytes, sphingosine remained to increase ML‐SA1‐induced TRPML1 channel‐mediated Ca2+ release (3.96 folds). These results suggest that the AC deficiency decreases TRPML1 channel activity due to reduction of sphingosine production, which may contribute to lysosome dysfunction and enhanced exosome release.


This paper proposes a new group-sparsity-inducing regularizer to approximate ℓ2,0 pseudo-norm. The regularizer is nonconvex, which can be seen as a linearly involved generalized Moreau enhancement of ℓ2,1-norm. Moreover, the overall convexity of the corresponding group-sparsity-regularized least squares problem can be achieved. The model can handle general group configurations such as weighted group sparse problems, and can be solved through a proximal splitting algorithm. Among the applications, considering that the bias of convex regularizer may lead to incorrect classification results especially for unbalanced training sets, we apply the proposed model to the (weighted) group sparse classification problem. The proposed classifier can use the label, similarity and locality information of samples. It also suppresses the bias of convex regularizer-based classifiers. Experimental results demonstrate that the proposed classifier improves the performance of convex ℓ2,1 regularizer-based methods, especially when the training data set is unbalanced. This paper enhances the potential applicability and effectiveness of using nonconvex regularizers in the frame of convex optimization.


olyarylsulfones play a special role in the range of polymeric materials available on the market: they have high glass transition temperatures (Tg) of around 200°C and so are suitable for producing extremely heat-stable components, and in fiberreinforced form they are providing competition for metals in particularly challenging applications. Polyethersulfone (PESU, e.g. Ultrason E, Veradel, Sumikaexcel), with a Tg of 225°C, meets the highest HT requirements of this family of materials. It has good inherent flame retardancy (up to V0 according to UL94, without additives) and good hotwater, coolant and chemical resistance, e.g. against oils and fats (up to about 170°C). PESU offers continuous service temperatures of 180 to 190°C. Special grades, such as Ultrason Dimension from BASF SE, Ludwigshafen, Germany, have a modulus of elasticity of more than 10,000 MPa and a low coefficient of thermal expansion at 120°C,yet are easy to injection mold due to their lower melt viscosities. Polyphenylsulfone


The article presents an analysis of the level of security of the Russian subway in comparison with European and American. The modern mobile Wi-Fi network of the Moscow subway, its advantages and known cases of attacks are considered. Highlighted the problematic issues of cyber security, which need to be addressed in security audits and in the process of creation and development of special operations centers to respond to cyber attacks. A model of a prospective center for early warning of group and mass cyber attacks on critical transport infrastructure is proposed.


The linearity of diffuse transmittance spectra was considered on the basis of the Kubelka–Munk theory. The sub-linear dependence of –logT on the component concentration was determined and a linearisation method is suggested. The main point of linearisation is solving a cubic equation with absorbance to be linearised as an unknown variable and with the equation coefficients being power functions of the sample scattering capacity. The performance of the method is tested by employing the spectra of adsorbed water in the 1796–2004 nm range. The cellulose sheet was a matrix for adsorbed water molecules. Seventeen water content values from 0.6% to 22.7% (w/w) were prepared for calibration–prediction procedures. Raw spectra and linearised spectra were analysed by principal component analysis and partial least squares (PLS) regression. PLS cross-validation shows the 2.85-fold decrease of the prediction error after linearisation.


: This paper explores two important concepts to illustrate the potential of managers "emotional and performance measurement capital" within the organization, as well as how to provide them with the means to achieve what we call "emotional leverage". Who could teach you such things? You ccould only experiment on them. I truly believe that it is appropriate in this scientific paper to get back to the initial question arises often in our work relationships: Can Leadership be taught? I am pretty sure that I am not the only one who has such curiosity; I believe we all at some point in life have wondered if we can feel as a born Leader or become a Leader. Through years, researchers have been trying to find answers. Learning is the process of knowledge transfer from one person to another, and quite often while lecturing and sharing it in leadership courses. It is commonly said that at the end students have to find out for themselves whether or not they are Leaders! Leadership begins with self-confidence, courage and perspective. Later in this paper a discussion of a very important emotional variable takes place called emotional intelligence, or how to understand and manage our own and others' emotions. The goal of this paper is to describe the distinguishing skills of a leader, despite the thousands of traits that characterize each leadership style; as well as, bring into readers' focus the successful leadership experiences and profiles of well-known people. However, the main aim is to measure how important the Leader's emotional intelligence in Albania is. In addition, how to understand and manage our own and others' emotions, is broken down.


Krasno and Ivy have claimed that the change after sublingual nitroglycerin in the frequency at which a flickering light appears to fuse (f.f.f.) sharply differentiates between cardiovascular normals and patients with coronary and /or hypertensive disease and that this test may be useful in detecting and evaluating such disease. On the basis of a detailed analysis of the original publication and of data on 304 men these claims are denied. Indications for further study of flicker phenomena are discussed and fiducial norms are presented. T HE FUSION frequency (or critical frequency) of flicker is that rate of successive light flashes where the sensation of flicker disappears and becomes the same as that of continuous light. There is reason to believe that the fusion frequency of flicker (f.f.f.) in a subject with normal ocular structures depends on the time parameter of excitability of the visual pathways," 2 primarily of the visual centers.3-' While the literature on the flicker phenomenon goes back over a period of one hundred years, the application to physiologic or clinical stress situations is quite recent. Simonson and co-workers6 found a decrease of the fusion frequency of flicker in fatigue of the central nervous system and in various types of pathology, among others in a group of 21 patients with heart disease.7 This seemed to be in harmony with observations on the fatigability of cardiac Published with the approval of the Chief Medical Director, Veterans Administration Hospital. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration. 215 patients in mental as well as in physical work, but no suggestions were made as to the potential value of this method for diagnosis or prognosis of cardiac disease. Recently, Krasno and Ivy' have reported studies on the fusion frequency of flicker before and after the sublingual administration of 0.4 mg. of nitroglycerin and stated, "We believe our results clearly show that the nitro-glycerin-flicker test has revealed the presence of arterial hypertonius or spasm of the retinal arteries in 99 per cent of patients with existing hypertension or coronary arterial disease" (p. 1274). Further, they suggest that "the nitroglycerin-flicker test may prove to be a valuable diagnostic aid (a) for the presence of angina pectoris and coronary occlusion where the evidence is equivocal, (b) for the detection and management of persons who …


Abstract Statebuilding as a panacea for post-conflict societies is a largely uncriticised notion, like the liberal democracy it articulates. But, according to some, the policy framework of large-scale transitional statebuilding is often inappropriate, in particular where its focus on liberal democratic forms either ignores or tries to overwrite structural determinants shaping particular national behaviours. Democratic assumptions run so deeply that, without necessarily having overt intent, the lack of reflection upon the paradigmatic assumptions of Western models, often results in the denial of legitimate and viable alternatives. A more minimal approach, which could be based upon limited externally-supported electoral support encouraging indigenous organisation, however, offers to reverse the imperious and democracy-orientated trend, and to promote internally legitimate plural-indigenous systems with long-term sustainability.