In order to investigate the effects of bolt-hole arrangement and edge distance of bolted joints on the ultimate tensile strength and failure modes of H-shaped tension members, we conducted tension tests of the H-shaped members jointed with high-strength bolts. Newly developed 780Mpa-grade and 590Mpa-grade high-quality steels, which had low yield ratios, were used for test specimens. We proposed formulas to predict the ultimate tensile strength of flanges and webs for tearing fracture and end fracture. The experimental results confirmed that the ultimate strength of the H-shaped member was obtained by the sum of both strength of flange and web. The ultimate strength of the prediction formulas, which had been previously obtained from the steel plate joint tests, to the H-shaped members was discussed. Also, the reliability of the design formulas specified in the LSD by AIJ and the LRFD by AISC was discussed based on the experimental results.


Primary cultures of cerebellar granule cells possess most glutamate receptor subclasses [ 1-31 and may therefore be utilized as a model neuronal system to study the receptormediated regulation of cytoplasmic free Ca2+ level ([Ca*+],). Dissociated cells were plated at a density of 750000/cm2 on to polylysine-coated coverslips and cultured in minimal essential medium supplemented with 10% (v/v) foetal calf serum, 20 mM-KCI, 30 mM-glucose and 2 mM-glutamine. 5-Fluoro-2'-deoxyuridine was added at 2 days in vitro (d.i.v.). At 7 or 9 d.i.v., coverslips were transferred to stirred thermostatted cuvettes containing modified Mg' + -free Elliot's medium with 1.3 mM-CaCl? and 3.5 mM-K+, and preincubated for 25 min followed by 40 min loading with 3 p ~ fura2-AM. In Fig. l (a ) the effects of depolarization and glycine addition upon the response to N-methyl-D-aspartate (NMDA) were monitored for 7 d.i.v. cells. 1-Hydroxy-3-aminopyrrolidone-2 (HA966; 100 ,LAM), which inhibits glycine activation of the NMDA receptor, was initially present in order to prevent activation by low concentrations of leaked endogenous glycine 141. KCI (30 mM) gave a large transient spike of [Ca*+], which declined to a plateau, consistent with the presence of both inactivating and non-activating components of Ca" entry. The subsequent addition of 100 p ~ N M D A resulted in a higher, sustained plateau, as has been previously reported [3, 51, which was further increased by the addition of 10 pM-glycine to compete with the HAY66. In this depolarized experiment, the NMDA response was only partially inhibited by 1.2 mM-Mg*+, but was completely blocked by 10 p~-MK-801 . The experiment was repeated in the absence of KCI-depolarization (Fig. l a ) . The response to NMDA and excess glycine was largely unaffected, although as expected the ability of Mg2+ to inhibit the NMDA response was greatly enhanced. In Fig. l (b) the interaction between kainateand quisqualate-induced responses was investigated for 9-d.i.v. cells. The [Ca*+], response to 100 pM-kainate is biphasic in these cells, with an initial spike followed by a slowly developing plateau. Since kainate inhibits Na+-coupled glutamate reuptake, causing a net release of endogenous glutamate [6], it is important to establish that the plateau after kainate is not due to released glutamate; thus 10 p ~ M K 8 0 1 produces only a slight decrease in the plateau (Fig. lb). Quisqualate (30 p ~ ) produces a transient spike, followed by a profound inhibition of the kainate-evoked plateau. The inhibition with quisqualate, but not the prior spike, is mimicked by the quisqualate receptor-antagonist 6-cyano-7-nitroquinoxaline-2,3dione at 1 PM (not shown). It thus appears that the [Ca'+], plateau with kainate requires the presence of functional quisqualate receptors; the depression in [Ca' '1, after quisqualate may reflect their inactivation. Granule cells possess inhibitory y-aminobutyric acid (GABA)A receptors 171; Fig. l (b) shows that activation of these receptors by 33 PM-GABA is able to inhibit the spike produced by kainate, indicating that this may be due to


Supplemental Digital Content is Available in the Text. Background: Glossokinetic artifact (GKA) is a well-known scalp EEG artifact characterized by deflections within the delta to low-theta frequency bands and dynamic polarity typically attributed to the direction of tongue movement. This study aims to investigate intracranial EEG correlations of scalp-GKA. If the tongue is a dipole, per the conventional view, then volume-conducted deflections are expected in the nearest frontal intracranial EEG contacts. Materials and Methods: Simultaneous scalp and intracranial EEG recordings were evaluated in five consecutive medically resistant epilepsy patients at Yale Epilepsy Center in 2017 and 2018, who had classic GKA deflections on scalp EEG. The EEG was sampled at 2,048 to 4,096 Hz and analyzed visually, using a reference placed in the diploic space or over the convexity, and confirmed quantitatively by a statistical framework. Ten GKA deflections were analyzed per case. Results: The medians of age at the time of recording, contacts per case, and amplitude of scalp GKA deflections were 35 years (range: 20–41 years), 171 contacts (range: 165–241 contacts), and 56 μV (range: 51–72 μV), respectively. There were no slow discharges in the frontal intracranial EEG contacts synchronized with the scalp GKA, either in the delta (1–3 Hz) or in the sub-delta (0.1–1 Hz) bands. However, the expected physiologic attenuation of alpha and beta rhythms and the emergence of high-gamma activity were observed over the peri-Rolandic regions in the invasive recordings. Conclusions: The traditional view of the tongue as a dipole generator of scalp GKA is simplistic and does not account for the findings reported herein. The tongue most probably shunts other scalp and soft-tissue currents. Knowledge of tongue potentials is of interest in the education and the design of tongue–computer interfaces.


A widely used bus-encryption microprocessor is vulnerable to a new practical attack. This type of processor decrypts on-the-fly while fetching code and data, which are stored in RAM only in encrypted form. The attack allows easy, unauthorized access to the decrypted memory content.


Motivation. The identification of natural products is a task that demands skilled spectroscopists in this area. The number of isolated substances has been enhanced significatively in the last years. So, trying to reduce the time spent during the identification this process, we developed a program able to predict the carbon skeleton for a compound from 1 H NMR data. For that, the natural product class selected in this study was the lignans, products showing some complex structures. Method. The H1MACH program was developed to assist the process of skeleton prediction of organic compounds from the 1 H NMR chemical shift data. Thus, a database containing 760 1 H NMR spectra data was elaborated. From the data, the program can predict the most probable skeleton type for a new compound under analysis and show several structures that have a high similarity index with the supplied data. Results. The program was evaluated with 30 lignan structures not stored yet in the database. The results show that the program was able to predict, in 70% of the studied cases, the correct skeleton of the compound. Analyzing more detailedly the results, one can verify that in 90% of the tests, the correct skeleton was predicted among the three first skeletons by the program. Conclusions. Regarding the obtained results, it can be concluded that the tests carried out with the program H1MACH showed good results, once that the signal multiplicity was not included in the database. The procedure here described can be applied for other classes of compounds. This new tool will increase the power of spectral data interpretation of the expert system SISTEMAT. Availability. The software used in this study can be consulted by getting in touch with with the corresponding author.


AIM. To analyse thе coping strategies leading to psychological maladjustment and the occurrence of autonomic nervous system disorders (ANSD) in residents of the Republic of Karelia (RK).
METHODS. Heart rate variability (cardiointervalography, rhythmography, spectral analysis) and coping strategies (adapted Lazarus coping test) were studied in 104 residents of RK suffering from ANSD (main group MG; sex index 1:1; mean age 36.810.7 years) and in healthy control subjects (CG; n=30; sex index 1:1; mean age 36.15.5 years; p=0.761).
RESULTS. It was found that the residents of RK with ANSD are statistically significantly (p 0,05) characterised by sympathicotonia in combination with high tension of such emotionally oriented coping strategies as escape-avoidance (in men 47,527,05/40,275,04%; in women 47,469,47/46,138,68% in persons of the MG/CG, respectively) without gender differences (p 0,05). Women used more often (p 0,05) use distancing (50,6710,09/43,077,56%; p=0,009) and taking responsibility (46,657,8/40,275,04%; p=0,002); whereas men underestimated (p 0,05) the coping strategy planning (49,888,2/56,46,31% in MG and CG; p=0,004).
CONCLUSIONS. For the primary and secondary prevention of ANSD in RK residents, it is advisable to take into account the specifics of heart rate variability (sympathicotonia) and coping strategies (emotionally oriented), which will optimise psychological adaptation to the disease through personalised rehabilitation programmes based on a biopsychosocial approach (a combination of pharmacological and psychological psychotherapeutic correction).


Nearly all writers on the subject of citizenship education agree that it is essential for preserving America's democratic way of life. Indeed, they often remind us that our nation's founders saw the preparation of competent citizens as the main purpose of schooling (Center for Civic Education 1994, v). Many contemporary people, too, believe that education's chief purpose is to equip students with the knowledge, skills, and values needed to function effectively as citizens of a democratic society (Wood 1988). And those who cite other educational goals as equally important (e.g., Boyer 1990) still concur that citizenship development is a significant aim of the schooling process.


The P‐to‐S converted phase at the Moho (the Pms phase) contains important information regarding the crustal structure. Here, we employ a grid search approach to simultaneously extract the bulk crustal azimuthal anisotropy and Moho orientation using receiver functions. The solution of this approach is the weighted average of two individual subfunctions that separately analyze the birefringence and arrival time of the Pms phase. Since a tilted Moho deflects the polarized components of the Pms phase, the Pms birefringence subfunction minimizes the energy on all the transverse polarization components (i.e., the transverse polarization direction before Pms splitting). The implementation of this subfunction is similar to that of the transverse component minimization method, but the Moho orientation is considered. The Pms arrival time subfunction takes into account both the crustal anisotropy and the Moho orientation to predict and fit Pms arrivals. According to extensive synthetic experiments, this approach is remarkably robust to the presence of strong anisotropy, a steep Moho, and slightly tilted fast axes (less than 30°). This approach is also highly tolerant of random noise and data with uneven azimuthal coverage. We apply this approach to three permanent stations on the Tibetan Plateau. The resulting measurements boast a high quality and are consistent with the crustal anisotropy and Moho orientation revealed in previous studies.


The current population trend is bringing new challenges to education:The new urbanization of the rural schoolage population is too dense and the urban school-age population is too close,selective two-child policy makes school-age population expect to have steady growth in urban areas,new-age population has a new demand for educational resources.This prompted center of gravity of school layout and adjustment shift:focus areas gradual transited from remote rural areas to large and medium sized cities,education stages extended from compulsory education stage to pre-school and highschool education stage,basic way change from merging school gradually into building,renovating or expanding school.So we should predict the trends and distribution of the school-age population scientifically,do the school layout plan ahead,support and regulate private education.


The structure and complexation behaviour of 1,3-alternate-1,2,3-triazole based on thiacalix[4]arene,1,3-alternate-1 and 2 have been determined by means of X-ray analysis, fluorescence and 1H NMR spectroscopy. The X-ray results suggested that the nitrogen atom N3 on triazole ring can act as hydrogen bond acceptors in the self-assembly of a supramolecular structure. The fluorescence spectra changes indicated that the thiacalix[4]arene bearing 1,2,3-triazole groups were highly selective for Ag+ in comparison with other tested metal ions by enhancement of the monomer emission of pyrene. The 1H NMR results suggested that Ag+ can be strongly bonded by the triazole groups with the cooperation of the ionophoric cavity formed by the two inverted benzene rings and the sulfur atoms of the thiacalix[4]arene.


Problem statement: The Oryx antelope is a grazing ruminant of the Bovidae family. The macroscopic anatomy of the stomach in one adult Oryx dammah, an extinct species in the wild, was described. Approach: The stomach of the Oryx was composed of the four classic compartments of the ruminants. The weight of all the full stomach was 21.5 kg. The ruminal papillae were distributed unevenly in the rumen. Results: The maximum height of the cristae reticuli was 0.3 cm. The Cellulae reticuli were divided and contained secondary and tertiary crests. The Curvatura omasi measured 30.0 cm and the omasum had 15 primary, 9 secondary, 30 tertiary and 34 cuaternary Laminae omasi. The abomasum had about 17 Plicae spirales abomasi. Conclusion/Recommendations: We concluded that the stomach morphology of the Oryx had characteristics of the others grazing feeders ruminants. An important limitation of this study is the fact that we used only one animal, further studies of the digestive system of this species are necessary.


Anemia commonly accompanies acute coronary syndromes (ACS) and is associated with poorer outcomes. This study examines the associations between anemia, management and outcomes in an Australian ACS population.


The durability of concrete structures is essential for reliable infrastructure. Although many deterioration models are available, they are rarely applied in situ. For existing structures in need of repair or durability assessment, this is also the case for Building Information Modeling (BIM). However, both BIM and durability modeling hold great potential to both minimize expended resources and maximize the reliability of structures. At the Institute for Building Materials Research (ibac) at RWTH Aachen University, a novel approach to the calibration of deterioration models using Bayesian inference iteratively in a BIM model enriched with machine-readable diagnosis data to achieve a predictive decision support tool is being developed. This paper demonstrates the digital workflow, validates the proposed approach, and expresses the added value for the planning of repair measures.


Objective:To study the curative effect and adverse reaction of gemcitabine combined with docetaxel in treating 28patients of advanced sarcoma.Methods:Twenty eight patients with advanced sarcoma were treated with gemcitabine 800 mg/m2 on days one and eight intravenously over 80 minutes,followed by docetaxel 100 mg/m2 on day eight intravenously over one hour.Treatment cycles were repeated approximately every three weeks.Results:Among 28 patients,one was complete response and 10 were partial response.The overall response rate was 39.3%.The progression free survival was 7 months.Responses occurred in osteosarcomas,such as Ewing's /PNET sarcoma,malignant fibrous histiocytomas,malignant peripheral-nerve sheath tumors,uterine leiomyosarcoma,and malignant mixed Mullerian tumor.Conclusion:The combination with gemcitabine and docetaxel seems to be active in sarcomas.The adverse reactions are tolerant.


The application of 3,5-bis(trifluoromethyl)phenylammonium triflate (BFPAT) as a convenient
new organocatalyst for the synthesis of quinoxaline derivatives is described. In the presence of
BFPAT, one-pot synthesis of a wide variety of quinoxaline derivatives was achieved by the reaction of
various o-phenylenediamines and 1,2-dicarbonyl compounds in water.


A method to achieve improvement in template size for an iris-recognition system is reported. To achieve this result, the biological characteristics of the human iris have been studied. Processing has been performed by image processing techniques, isolating the iris and enhancing the area of study, after which multi resolution analysis is made. Reduction of the pattern obtained has been obtained via statistical study.


A dynamic model of a combined radiant floor heating (RFH) and domestic hot water supply (DHWS) system is developed and validated by using measured data gathered from an experimental test facility. The validated model was used to study the dynamic responses of the system under different operating conditions. Optimal control and predictive control strategies were designed and simulated to study system performance and energy consumption. Results showed that the control strategy with the heating load prediction could save up to 12.7% energy. Also, the optimal control strategy with optimal set-points could save 8.6% energy input to the boiler and 42.9% pump energy consumption while maintaining the zone temperatures and DHWS temperatures close to their respective set-points.


This thesis studies the quantum amplitude amplification algorithm and some of its applications in the field of property testing. We make use of the amplitude amplification algorithm to design an algorithm testing the linearity of Boolean functions which is more efficient than the previously best known quantum algorithm. We then generalize this new algorithm to test if a function between two finite abelian groups is a homomorphism. We improve on the previously best known algorithm for testing the symmetry of Boolean functions and use this new algorithm to test the quasi-symmetry of Boolean functions. Next, we further the study of the query complexity of the amplitude amplification algorithm for unknown initial amplitude. We give a rigorous description of the random variable representing the number of queries made by the algorithm and present the previously known result on its expected value upper bound. We then provide new results on the variance of this random variable. It is shown that, in the general case, the variance cannot be bounded above. We show, however, that it can be bounded for an appropriate choice of parameters.


Higher education institutions across the globe are increasing the extent to which they teach in a blended mode. However, in the rush to transition to blended teaching, institutions often fail to systematically review their transition process. Via a case study of one institution's transition to blended teaching, this paper aims to assist other institutions make similar transitions. Numerous recommendations for how institutions can advance their transition to blended learning are deduced. The investigation triangulates three data sets collected from: (1) methodical observation of the learning management system (LMS); (2) interviews with unit coordinators; and (3) a large-scale student survey. It was found that although both students and academics were receptive to blended learning, neither had a clear understanding of what it was. There is wide variability in the structure and quality of blended units and LMS sites. Lifting the standard of poorer quality blended units requires considerable investment to provide academics with time and resources. Students were on average satisfied with the online aspect of blended learning; they were particularly satisfied with procedural efficiencies, but less so with socially interactive aspects of learning. Overall, blended learning appears to enhance engagement, providing more avenues for students to engage with learning materials.


The significant recent findings in our laboratory are as following: (1) The synthesis and crystal structure of the first "carbons apart" C4B8-carborane provided an indirect evidence for the existence of a carborane cuboctahcdron, a geometry that was proposed by Lipscomb in 1960 as an intermediate in his classic DSD mechanism for the thermal rearrangement of ortho-carborane to meta-carborane. (2) The first examples of fully sandwiched anionic lithia- and magnesacarboranes and half-sandwich cesia- and magnesacarboranes have been synthesized and structurally characterized. (3) A number of half- and full-sandwich galla- and indacarboranes were synthesized and their reactivities at the metal center for further complexation were explored. (4) The lanthanide metal reagents exhibited a different reactivity pattern with the "carbons apart" carborane ligands than with the corresponding "carbons adjacent" counterparts and further exemplify the role of solvents in determining the course of reactions in these systems.


SUSAN BROADHURST AND JOSEPHINE MACHON (EDS), PERFORMANCE AND TECHNOLOGY: PRACTICES OF VIRTUAL EMBODIMENT AND INTERACTIVITY (PALGRAVE MACMILLAN, 2011)Originally published in hardback in 2006, this absorbing volume contains a wide range of essays on performance practices that use new technologies such as motion capture, 3D virtual environments, artificial intelligence and even artificial biological systems - in the case of the Tissue Culture and Art project. The book's broad sweep captures some of the energy, anxiety and excitement emanating from a range of genuinely exploratory projects, which raise crucial questions about the ways in which technology transforms our understanding of performance, human perception and, perhaps most importantly, the relationship between the corporeal and the virtual. Most chapters have a practical orientation, and contain extensive descriptions of specific performances, providing a compelling snapshot of the current state of play in this nascent field. Broadhurst and Machon point out that while the various projects in their book use a multitude of technologies, they are almost all engaged with the digital, which requires 'a new mode of analysis and interpretation which foregrounds and celebrates the inherent tensions between the physical and the virtual' (xvii).The book begins with Susan Melrose's 'Bodies Without Bodies', perhaps the most provocative and theoretically dense chapter. Melrose interrogates the meaning and function of the word 'body' in writings about performance, professing ignorance about what this word signifies in such contexts - implicitly chastising those who use the term loosely, and without knowledge of its complex meanings. Drawing on a rich range of theoretical sources, such as Heidegger, Spinoza, Zizek, Deleuze and Guattari, Melrose unpacks the word's etymology, noting that uses of the term 'bring with them a veritable network of values (measures) and potential unfoldings' (9). As I read her, Melrose, in her characteristically opaque prose, expresses an anxiety about the tendency for scholars to write about new technology with reference to 'old' concepts. More specifically, she notes that academics display a particularly 'ontic' disposition in their writing by valorising the familiar without comprehending how conventional understandings of terms like 'performance' and 'audience' are radically transformed by the virtual. 'Even where "posthuman" sympathies are evidenced', she observes, 'the orders of expert writing wins out, by maintaining certain sorts of spectator perceptions' (11). This sort of writing, Melrose contends, is produced by scholars, and therefore appeals to those who occupy the hallowed halls of academe. Melrose expresses in this, and other recent writings, an anxiety about the gulf separating academic discourses on performance from what she calls 'professional' or 'expert' intuitions. I accept her general point that the scholarly analysis of performance produces ontic knowledge - that is, formal descriptions of properties - as opposed to what Elizabeth Grosz describes as 'an attuned empiricism that does not reduce its components and parts but expands them to connect this object to the very universe itself (13). However, I am not convinced that these two forms of knowing are mutually exclusive, nor do I accept that 'ontic' analysis is the sole preserve of academics. It is becoming increasingly difficult to maintain the distinction between scholars and practitioners as increasing numbers of artists enter the university as higher degree students in Performance Studies and cognate disciplines.Steve Dixon's chapter, 'Truth-Seeker's Allowance: Digitising Artaud', lacks the sophistication and elegance of Melrose's argument. He mostly just describes work that uses new media technologies to enable the quest for artistic truth, with specific reference to Artaud. Dixon's company, The Chameleon Group, use video projections together with live performance 'to explore and expose serious existential issues, altered mental states, and metaphysical notions' (19). …


The optimum number of blocks of the CBFM is derived theoretically and demonstrated numerically. The minimum order of CPU time for the CBFM is shown to be O(N7/3) , where N is the number of unknowns. In addition, the optimum size of overlapping region of the blocks also is investigated numerically.


Protecting chemical clusters from intentional attacks has been a hot topic during the last decade. Besides intrusion security countermeasures such as cameras, entrances control etc., patrolling also fulfils an important role in the security of chemical facilities and industrial parks. Current patrolling strategies in industry are mainly single-plant driven and purely randomized or based on the patroller's preference. Such an approach in a chemical industrial park is on the one hand not able to cover the more hazardous facilities more than the less hazardous plants within the park, and on the other hand is not able to deal with strategic (intelligent) human adversaries w.r.t. terrorism. This paper therefore investigates a game theoretic model for optimizing the schedule of patrolling in chemical clusters. The industrial defender and the intelligent/adaptive attackers are modelled as two players in the game. The defender aims at increasing the probability of detecting the attacker, by randomly but strategically scheduling her patrolling route. The attacker aims at causing maximal consequences with highest success probabilities, by choosing a proper attack time and a proper target. The model is further illustrated by a case study. deal with intelligent attackers. Some patrollers follow a fixed patrolling route, and the attacker thus can predict the patroller's position at a certain time. Other patrollers purely randomize their patrolling, without taking into consideration the hazardous level that each facility/plant holds, and the attacker can attack more dangerous facilities/plants since all the facilities/plants are equally patrolled. Game theory has been introduced to the security domain to optimally allocate security resources. In a security problem, the attacker (human beings) is able to plan his attack according to the defender's defence, while the defender knows the fact and thus she can also defend accordingly. This procedure is called the 'intelligent interactions' between the defender and the attacker. Game theory was invented to model strategic decision making in multiple actor systems, thus it perfectly fits the necessity of modelling the 'intelligent interactions' in the security domain. Tambe and his co-authors [4] employed game theory for optimizing patrolling of protecting ferries, of protecting wild animals etc. Alpern and his co-authors [5] theoretically studied the optimization problem of patrolling in a graph. Amirali et al. [6] introduced a game theoretic model for optimally scheduling pipeline patrolling. No literature has investigated the use of game theory to optimize patrolling in chemical clusters, neither for the single plant patrolling nor for the multiple plants patrolling.


Thirty eight fungal strains were isolated from local agricultural soils out of which eleven strains of Aspergillus niger and Aspergillus fumigatus showed zone of phosphate solubilization. These strains were further screened for their thermotolerant character by plate and broth assay method. A. niger F24 and A. fumigatus F27 showed the highest solubilization index 2.57 and 2.86 at 40 0 C and 1.96 and 2.13 at 45 0 C and solubilized 246µg/ml and 290µg/ml of tri- calcium phosphate at 45 o C with drop in pH. Thus, the use of these microorganisms as biofertilizers, even in hot summer may not only compensate for higher cost of manufacturing fertilizers in industry, but also mobilizes phosphate present in agricultural soil in hot summer season.


A variety of attempts to synthesize oxacyclododecindione macrolactones through carbonylative ring-closure, intramolecular alkyne hydroacyalation, and Ru-catalyzed double bond isomerization fails.


This paper presents design steps of a distributed generation system with load power compensation. A single-phase full-bridge converter is used to connect the alternative source to the mains. Besides injecting active power, the distributed generation also provides load power compensation capability. In this context, a current reference strategy based on single-phase circuit theory is proposed for grid-connected multi-task converters. The main idea is to synthesize the signal reference for control loop generating orthogonal signals from grid voltage and current load. A Third Order Sinusoidal Integrator is used to extract fundamental component and generate the orthogonal waveforms of grid voltage and load current. Current controller loop for interface converter is developed based on Linear Quadratic Regulator theory. Simulation results are presented to verify the system behavior.


We investigate the electroweak phase transition (EWPT) in the Minimal (One Higgs doublet) Standard Model (SM) with account for the spontaneous generation of magnetic and chromo-magnetic fields. As it is known, in the SM for the mass of a Higgs boson greater than 75 GeV, this phase transition is of the second order. But, according to Sakharov's conditions for the formation of the baryon asymmetry in the early Universe, it has to be strongly of the first order. In the Two Higgs doublets SM, there is a parametric space, where the first-order phase transition is realized for the realistic Higgs boson mass mH = 125 GeV. On the other hand, in the hot Universe, the spontaneous magnetization of a plasma had happened. The spontaneously generated (chromo) magnetic fields are temperature-dependent. They influence the EWРT. The color chromomagnetic fields B3 and B8 are created spontaneously in the gluon sector of QCD at a temperature T > Td higher the deconfinement temperature Td. The usual magnetic field H has also to be spontaneously generated. For T close to the TEWPT , these magnetic fields could change the kind of the phase transition.


Abstract : This report documents the observations of velocity, temperature and conductivity made in the Mid-Atlantic Bight region of the NW Atlantic Ocean during the Synthetic Aperture Sonar (SAS) Primer experiment. The primary data were obtained from instruments moored in 70 m of water near 40 deg 30' N, 70 deg 30' W, from July through September 1996. Vertical profiles of conductivity, temperature, light transmission and fluorescence were also made during deployment and recovery cruises. The overall goals of this PRIMER program are to assess the feasibility of the operation of an SAS on the continental shelf. A study of acoustic propagation was conducted during the period the mooring was deployed, from August 20 through August 27, by F. Henyey, T. Ewart, and K. Williams (Applied Physics Laboratory / University of Washington). The evaluation of the synthetic aperture sonar itself was performed by S. Stanic and R. Meredith (Naval Research Laboratory). This project was carried out in close cooperation with the ONR-sponsored Coastal Mixing & Optics ARI. In addition to shared logistical planning, we anticipate joint analysis and sharing of data. The specific goals of this project are to describe the internal wave field and associated sound speed fluctuations on the shelf--both statistically and by events. The sampling scheme was designed to resolve the many components of the wavefield including: near-inertial waves, internal tide, background continuum and internal solitary waves.


Researchers in human‐computer interaction (HCI) often use discrete multipoint scales (such as 5‐ or 7‐point scales) to measure user satisfaction and preference. Many knowledgeable authors state that the median is the appropriate measure of central tendency for such ordinal scales, although others challenge this assertion. This article introduces a new point of view, based on a human factors consideration. When decision makers read a usability report or attend a briefing, they may make decisions based on the magnitude of the difference between the measures of central tendency for key dependent variables. A major criterion that should affect the choice of presenting means or medians is the strength of the relationship between this difference and the observed significance levels of appropriate statistical tests. The results from two series of "real‐world" usability studies showed that the mean difference correlated more than the median difference with the observed significance levels (both parametric and non...


warranted to determine the clinical utility of hsTnI and CMR-ECV in providing risk stratification for arrhythmias and thus refine patient selection for pre-emptive ILR insertion. Background : The reliability of clinician grading of systemic sclerosis (SSc)-digital ulcers (DUs) has been reported to be poor to moderate at best, which is a major concern in clinical trial design. The aim of this study was to examine the reliability of new proposed UK Scleroderma Study Group (UKSSG) DU definitions (no ulcer, healed ulcer and DU) amongst UK for and A of unique 230 image were obtained. For intra-rater reliability, across all of the rater) the overall weighted kappa coefficient was high and was moderate (0.55) when averaged across all individual raters. Overall inter-rater reliability was poor Intra-rater reliability was high for both the dichotomised analyses of preventative ( k ¼ 95% ¼ and treatment ( k ¼ 95% CI ¼ analysis. Inter-rater reliability was fair for the dichotomised analyses of preventative ( k ¼ 0.25, 95% CI ¼ 0.19 -0.31) and moderate for treatment ( k ¼ 0.41, 95% CI ¼ 0.33 0.49) analysis. rating as an outcome measure in clinical trials, including examining the role for objective measurement techniques, centralised image analysis and the development of novel approaches such as the development patient reported outcome instruments for assessing SSc-DU. Disclosures : The authors have declared no conflicts of interest. Background : In systemic sclerosis (SSc) Th2 cytokines provide a possible mechanistic link between autoimmunity and the fibrotic pathology seen. IL-31 is a recently described Th2 cytokine which signals via the oncostatin M receptor/IL-31RA dimer. We sought to determine whether IL-31 is elevated in SSc plasma or blister fluid (BF), and test whether the IL-31RA is expressed by cells relevant to the disease process. The fibrogenic potential of IL-31 was evaluated in a mouse model. Methods : IL-31 was measured by ELISA of plasma and BF (SSc n ¼ 44, HC n ¼ 27). IL-31RA mRNA was assayed by qPCR of SSc and HC fibroblasts, epidermal tissue extracts, and fat derived MSCs. Responses of target cells to IL-31 were measured by next generation sequencing (NGS), migration assays, qPCR and Western blotting. IL- 31 (200ng/day) was delivered by subcutaneous minipump with or without TGFbeta (800ng/day), or saline control for 14 days in wild type Balb/c mice (6-7 per group). Results : Plasma IL-31 was elevated in SSc (HC range 0-792pg/ml, mean 196, SEM 48, SSc range 0-17764, mean 1370, SEM 567, p < 0.048). BF IL-31 trended towards elevation in SSc


Summary In this paper we studied how the system of 'Drawings Approved' (DA) functions as a barometer of competitiveness in the Indonesian automotive industry. Companies using the system of DA demonstrate four specific skills that help them gain trust from car manufacturers. Many local suppliers in Indonesia are 'vendors of drawings supplied' (DS), so customers are able to replace them with others because the drawings are unprotected and imply no obligation to collaborate. Local automobile parts suppliers in Indonesia need to improve client approval functions urgently in order to survive in the industry.


This study concerns the geographical relationships between alcohol consumption per capita; smoking and death from cirrhosis of the liver and cancer of the oesophagus in persons of 15 years old and over in Quebec [Canada]. First the geographical distribution of variables is analysed. Secondly we have used methods of correlation and regression in order to evaluate their relation to each other. In the latest case we have chosen the logistic regression model to investigate the simultaneous effects of alcohol and tobacco. The results indicate a significant relationship between alcohol consumption and mortality from cirrhosis of the liver but no such relationship for esophageal cancer. (summary in ENG) (EXCERPT)


Abstract : For predicting total cloud amount, screeningregression equations (12-, 24-, and 36-hr predictions) and multiple-discriminant-analysis (MDA) probability tables (24-hr prediction only) were derived by statistical methods from a 5-day sample of upper-air analyses and prognoses from Feb. 1962. Significant predictors were found to be total-cloud-amount persistence, moisture content (CPS), vertical velocity, 850-500-mb thickness, 500-mb height, wind divergence, thickness advection, and zonal and meridional wind components. Relations were derived to include prognostic terms only, lagged-analysis terms only, and a combination of the two. Application of the relations to the dependent data and to a small sample (194 cases) of independent data showed that: (a) relations based on prognostic variables and persistence (as predictors) are superior to the others; (b) MDA yields slightly better results than screening regression; (c) relations derived for cloud specification, when converted to prediction relations, do not yield as satisfactory results as prognostic relations; and (d) the statistical techniques yield results superior (based on percent-correct scores on independent data) to persistence or climatology. (Author)


This paper is concerned with predictive control theory for position and speed modes of synchronous motor in servo system. The dynamic and static characteristics of synchronous motor are satisfied, by transforming drive control into L/sup /spl infin// predictive control on multi-models. The experiment and the simulation results show that the proposed algorithm is right and effective. This system not only is feasible, but also is of fine performance with strong robust property and anti-interference property.


The problem of psychological rehabilitation of deprivation adolescents requires a comprehensive approach in addressing the psychological problems. Identifying characteristics of deprivation adolescents is one of the goals of the special psychology. The identified and described specific emotional status and personality characteristics of deprivation adolescents are shown.


The Transatlantic power dynamics that defined the world order following the Second World War have changed. Increasingly, the strength and influence of the U.S.-led Western international system are being eroded. Where the United States' vision of the world once dominated, China's view is becoming ever more relevant. Many International relations and security experts posit that there is an inevitable shift in global power occurring from the Atlantic to the Pacific. This power transition, they advance, has been occasioned by China's meteoric transition to modernity, its phenomenal pace of economic development and expanding influence on the international system these past few decades.The manifestations of China's impact on the United States and the U.S.-led international system are seen today in the continued scuffles between the two nations. The fault lines range from competing core interests to territorial disputes in the South China Sea and now a pivotal shift in U.S. foreign and security policy toward an increasingly assertive China. In view of these events, many scholars of international relations affirm that China and the United States are inescapably engaged in a power transition process, one with significant ramifications on the present system of international relations.This paper thus seeks to decipher the meaning of power transition and relies on the theory of power transition to provide a theoretical underpinning to its analysis. It further discusses past occurrences of such transitions and the watershed moments that marked them. The paper then dwells on the nature of U.S. - China relations and the rise of China and its impact. It concludes with a supposition of the future of U.S.-China relations in light of the two nations' divergent interests and what it portends of the present power transition process.


This paper introduces a small steam expander linked to a moderate/small industrial steam boiler to form a small scale cogeneration system for the purpose of energy conservation and carbon-emission reduction. Here, a traditional regulator will be replaced by the steam expander. In order to effectively extract the high pressure steam's unused energy (flow energy) from the boiler, the steam will be induced into an expanding process. Here, a Pulse-Steam Stirling Expander (PSSE), which is different from a normal steam expander, is proposed in the study. In order to decrease the steam condensation and increase the overall output power, the PSSE expander adopts an isothermal process instead of the traditional isentropic process. The PSSE cycle, which is composed of an isothermal process and an isovolumetric process, is similar to the Stirling cycle. Therefore, considering the influence of the valve's opening/closing within the PSSE cycle and adopting the Stirling engine's Schmidt theory, the mathematical model of the PSSE cycle has been established. The characteristic analysis of the PSSE expander has been assessed based on the mathematical model. Moreover, a prototype of the PSSE expander has been constructed and tested. According to theoretical analysis and experimental data, the output power for the PSSE expander is closely related to the phase angle between the displacer and the piston. Consequently, the mathematical model of the PSSE expander proposed in this study can be applied to design the practical PSSE expander in industry.


Background and Objectives The Rh system is genetically controlled by the homologous RHD and RHCE genes that encode the RhD and RhCcEe polypeptides, respectively. Deletions, point mutations and rearrangements between both genes are responsible for the great polymorphism of this system. The aim of this work was to analyse the genetic basis of a Dc‐ phenotype.


Single crystals of [(THF)LiCl]n (1) were obtained by the reaction of (PhCH2)2GaCl with LiSe'Bu in THF/toluene. 1 is polymeric in the solid state and crystallizes in the space group Pbcn, Z = 8, lattice dimensions at -83 °C; a = 1438.6(2), b = 1140.9(2), c = 746.2(1) pm, R1 = 0.0395


This paper deals with the issue of adaptive observer-based stabilization for a more general class of uncertain switched stochastic nonlower triangular nonlinear systems with average dwell-time (ADT) switching. The completely unknown nonlinear functions possessing the entire states are handled using the neural networks universal approximation property and the variable separation technique. The main novelty of this paper is that it presents a universal formula for constructing an adaptive output-feedback controller of the considered system with only one adaptive parameter by designing a switched state observer. The theoretical analysis shows that the Lyapunov stability of the overall closed-loop system is ensured in the presence of ADT switching. Finally, the effectiveness and practicability of the obtained design scheme are illustrated by two simulation examples.


Objective:To design and prepare a field battle "Windbreaker" stretcher for fixation of spinal cord injury using macromolecular material,and to determine its application index and assess its efficacy.Methods:Using shape memory waterborne polyurethaneurea/SiO2 nano-composite,we prepared a field battle "Windbreaker" stretcher for fixation of spinal cord injury according to the physique of the Chinese.The time spent to finish the fixation procedure under different conditions(raining,cold weather,land and rivers) was recorded,and the time of solidification was also observed.Results:The weight of a complete set of the field battle "Windbreaker" stretcher was(7.5±1.4) kg.The time to complete a fixation was(2.1±0.55) min in the water,(1.9±0.35) min under dry environment.The time of solidification was(7.7±1.45) min in the water and was(6.9±1.23) min under dry environment.The maximum strength the stretcher could bear was(80±5.7) kg.Conclusion:Our self-designed "Windbreaker" stretcher can be used for rapid and simple fixation of different spinal cord injuries,and the mechanics intensity meet the requirement for fixation.The stretcher can be used for fixation of spinal cord injury under different conditions of field battle.


This paper analyzes how the housing development Cidade de Águeda in Rio Grande, RS, was formed. It is considered a landmark in city policies on dwelling for families that have a low income after the Banco Nacional de Habitação (BNH), a bank that finances housing projects, was closed. The development with poor infrastructure and far from downtown was improved after it was occupied at the beginning of the 1990's. Nowadays, it has three distinct areas where houses have structural problems, where there are law suits which aim at regularize the area, and where most dwellers depend on social assistance programs. Key-words: Public policies; Popular dwelling; City.


This article examines the public legitimacy of the National Assembly for Wales. Both the Assembly and the broader system of devolved government for Wales initially enjoyed very limited public support. It is shown that support for devolution in general has risen substantially, while some elements of public attitudes towards the Assembly itself now appear distinctly positive. However, it is also demonstrated that public legitimacy, defined as 'diffuse support' for the Assembly, remains limited. The article then examines what factors explain levels of diffuse support for the National Assembly. It is found that variation in such support is best accounted for by factors associated with 'non-material consequentialism': perceptions of the impact of the Assembly on the process of government. The conclusion assesses the implications of the findings for the National Assembly, as well as for the study of devolution and political institutions more generally.


In this paper is described the thermodynamic model for underground coal gasification (UCG) and it is use for optimal adjustment for input parameters. For UCG process the input quantity of oxidizer (air, oxygen, water steam) is an important input parameter, respectively for process control his volume flow. In the case of a known quantity of coal for underground coal gasification it is possible by using the thermodynamic model and system optimization with model to determine the needed quantity of oxidizer. The thermodynamic model is one of the basic blocks of the system optimization with model. Another important block is the objective function, which mathematically expresses objective of optimization. The paper presents the application of gradient method to determine the input parameters of the UCG process in different variants of objective function.


Tbe current scientific status of psychology and psychiatry are como pared. from the point of view of a psychiatrist. The work of Jean Piaget il analyzed in...


As a developing country, it is the interest of Indonesia to ensure that the superimposition of WTO TRIPs provisions on traditional knowledge would not harm national interest. The author notes that traditionalism, which favours harmony between man and nature, has been widely known to be the way of life of many Indonesians. On this matter, the WTO's set of rules concerning intellectual property rights must be greeted with caution as it may contain western or industrialistic values. This article attempts to explain the WTO rules on traditional knowledge and the Indonesia's traditional knowledge bill.


It is generally accepted that geographical information or G.I. (such as texts, maps and tables) is chiefly composed of 3 kinds of criteria : spatial, temporal and thematic criteria. The main focus of this article is spatial criteria. More specifically, we have developed a processing sequence that can extract the spatial information contained in non-structured cultural heritage texts. This processing sequence indexes spatial information, which enables information retrieval (I.R.) based on the same criteria. Our goal is to normalize heterogeneous spatial information. This normalization is carried out at the index level by grouping spatial information together and by using statistics to calculate weights of spatial areas and the pertinence of the results. Thus, we aim to develop a general IR strategy that is dedicated to spatial information, but which can be applied to temporal and thematic information as well. By generalizing this approach, homogeneous IR strategies will be able to combine spatial, temporal and thematic criteria for more efficient geographic IR methods.


In a small undergraduate class at Harvard in 1967, Saul Kripke presented a revolutionary non-descriptivist view of the reference determination of proper names.1 A later version of these lectures was delivered at Princeton in 1970, published as the paper "Naming and Necessity" (1972), and finally published as the book Naming and Necessity (1980). In these works, Kripke is careful to claim that he is not presenting a theory of reference but rather "a better picture—a picture which, if more details were to be filled in, might be refined so as to give more exact conditions for reference to take place" (1980: 94). In a recent paper, Andrea Bianchi claims that "forty years later, we do not possess a fully blown theory built on this picture" (2011: 264). I found Bianchi's claim both surprising and disappointing, for I thought that I had proposed just such a theory. Kripke's Harvard lectures inspired my first attempt in a dissertation, "The Semantics of Proper Names: A Causal Theory" (1972). A more polished short version of the theory was published in "Singular Terms" (1974) and a more polished long version, in Designation (1981a). So, what is Bianchi's problem? He thinks that what I proposed does not count as a theory of reference for proper names because it does not have the form of a biconditional along the lines of: "proper name a refers to x iff aRx." And Bianchi insists that a theory must have that form. Now I did offer a biconditional of the sort that Bianchi wants in my initial development of a causal theory in Designation, before considering the problems of confused reference and reference change. But Bianchi is right that I did not present the final theory, which takes account of those problems, as a biconditional. My focus


A worldwide challenge in metropolitan areas is to accommodate more people traveling to, from, and within the city. In many cases, the possibilities to mitigate congestion by constructing new routes and increasing roadway capacities have become more and more limited and often cost prohibitive. Therefore, means to improve the planning and operational aspects of transportation operations to maximize the utility of the existing transportation network are the focus of transportation research and current practices. Microscopic traffic simulation is a modeling approach and analytical tool that is now increasingly used to support planning and operation decisions. It provides a better representation of time dynamics and congestion build-up as well as the interrelation between operations and impacts. However, building a large-scale microscopic simulation models is costly and demanding in terms of data inputs, calibration efforts and computational resources. It is also not cost efficient to build simulation models from scratch for individual projects. Our experience shows that the development of new simulation models could be greatly facilitated by linking with existing regional travel demand models and the integration is also beneficial in the long turn for maintaining the consistency between planning and operational analysis. This paper presents an implementation framework for integrating regional planning model with microscopic traffic simulation along with real-world examples. It also discusses the challenges of the macro-micro integration and experiences that authors learned though different projects.


This article aims to bring reflections on the training of professionals in the field of agroecology to work in the Technical Assistance and Rural Extension (ATER) services based on a new socio-technical perspective. For this, field research was carried out between the years 2016 to 2018 focusing on professionals linked to public institutions and social organizations working in the provision of ATER services in the states of the Southeast Region of Brazil (Rio de Janeiro, Espirito Santo, Minas Gerais and Sao Paulo). The authors resort to a debate on Rural Extension and its connections with the transition to agroecology as one of its fundamental principles, incorporated into the National Policy for Technical Assistance and Rural Extension (PNATER) even though relativized by Law 12.188 / 2010, which adopted the term ecologically based agriculture to replace agroecological bias. The results achieved through the different training strategies implemented in the studied region are presented and discussed in detail. Regarding the training of Ater agents in the context of Agroecology, it was observed that this framework is treated as a scientific, lively, interactive and challenged approach, which seeks to recognize in its protagonists, especially in family farmers and their organizations, an important role for the rural development of the Brazilian countryside.


Interferon α gene was cloned from genomic DNA of Chinese Luxi yellow cattle by PCR,and the PCR product was inserted into vector pET32a+ to make a recombinant plasmid pET32a+/BoIFN-α.The expression of BoIFN-α in Escherichia coli was induced by addition of IPTG.Sequence analysis showed that the Chinese Luxi yellow cattle IFN-α gene is composed of 498 nucleotides,encoding a mature polypeptide of 166 amino acids.Compared with other BoIFN-α subtypes,it shares the highest identity of 97.6% to the C-subtype.SDS-PAGE results showed that recombinant proteins were expressed in inclusion bodies in Escherichia coli with molecular weight of 40 ku,and the recombinant proteins accounted for 26.7% of the whole proteins.The expressed product was puried by affinity chromatography with immobilized nickel chelating NTA(Ni-NTA).Antisera against BoIFN-α was prepared by immunizing rat with the purified protein.The expression and purification of the recombinant BoIFN-α fusion protein and preparation of the antisera against BoIFN-α will lay a foundation for the future application of BoIFN-α.


Figure 1 shows that the model setup and its mechanism are quantitatively important. The left panel shows that to nonfinancial firms, financial intermediaries are the most important suppliers of money-like securities. The right panel shows that nonfinancial firms are among the most important buyers of intermediaries' money-like liabilities. Money-like assets include various financial instruments. Accordingly, "deposits" in the model should be interpreted broadly, including short-term debt issued by financial intermediaries that either serves as a means of payment, such as deposits at commercial banks, or close substitutes (usually held through money market funds by corporate treasuries), such as repurchase agreements and high-quality asset-backed commercial papers. The left panel of Figure 1 decomposes the money-like assets of U.S. non-financial corporations by the types of securities, and for each security, by the types of its issuers. I use the data in December 2015 from the March 10, 2016 release of the Financial Accounts of the United States ∗The Ohio State University. E-mail: email@example.com


Abstract We describe a new approach for quantitating furocoumarin adducts in DNA using enzymatic hydrolysis followed by resolution and recovery of the adduct molecules by electrophoresis on polyacrylamide tube gels. The resolution of this method approaches that of high pressure liquid chromatography but at a considerably lower cost. Digestion conditions using DNase II and spleen phosphodiesterase II to yield mononucleotides and adducted bases were worked out for DNA containing 8‐methoxypsoralen or 4′‐hydroxymethyl‐4,5′,8‐trimethylpsoralen. The phosphatase activity of DNase II was shown to be much more active on dNMPs than on adducted bases. This can be exploited to reduce the background of radioactivity from labeled dNMP's trailing into the adduct peaks, thereby increasing the effective sensitivity of the technique when quantitating adducts made with non‐radioactive drug in labeled DNA. Since resolution of adducts requires dense (30%) acrylamide gels, we have devised a method for making extremely uniform high density gels by polymerization under static pressure. A continuous collection apparatus was constructed to recover material from gels. The identity of the resolved species was determined by several different methods, including analysis by HPLC.


Abstract This paper explores the author's experience as a cancer patient. She explains why she did not seek talk therapy after learning of her diagnosis. Instead, art therapy provided access to her unconscious and helped her process bodily changes after surgery. It facilitated communication of her experience to others and expanded her self-definition. She describes the importance of other avenues of non-verbal communication, including touch, and concludes that many different modalities may provide support and comfort during critical life crises.


~(222)Rn/~(220)Rn is a radioactive gas full of everywhere on Earth,the study of ~(222)Rn /~(220)Rn has been an important issue in radiation protection and environmental protection.At present,the accurate measurement of Rn is already built up,but the measurement standards of ~(220)Rn concentration has not been fully established yet.The joint measurement of ~(222)Rn/~(220)Rn concentration can be mainly divided into double membrane spectroscopy, delay method using scintillation cells,parallel measurement using solid state nuclear track detector,activated carbon filter paper method and electrostatic collection method.At home and abroad ~(222)Rn/~(220)Rn comeasuring instrument mainly includes FD-129 ~(222)Rn/~(220)Rn detector,LR-115 solid state nuclear track detectors, RAD7 radon monitor,and so on.


824 cases were selected it was observed here that variation of temperatures affects various factors of blood and vascular bed (decrease in antithrombin III, increased aggregation of red blood cells, vascular spasm and increase viscosity) lead to increased incidence of cerebrovascular accidents


Introduces some relative concept about the multi -objectives and the PARETO solution,proposes an IAGAMO model according to the auto-adapted mechanism,and elitist preservation method and so on to enhance search efficiencies of GA,and with making some design on the multi-objective function's structure. Gives a case to simulate and compare using IAGAMO algorithm based on the PARETO in the production,which can be better comfortable to the production application with the obtained PARETO solution.


Nitrogen mustard (NM) was among the earliest drugs used to treat malignant tumors, and it kills tumor cells by cross-linking DNA. Unfortunately, because of the short half-life and unfavorable selectivity, NM causes significant damage to normal tissues. As NM can increase the levels of reactive oxygen species (ROS) in tumor cells, a ROS-activated nitrogen mustard prodrug (NM-Pro) was synthesized and mixed with NM at a specific ratio to obtain an "NM-ROS-NM-Pro-NM" positive feedback system, which ultimately achieves a specific lethal effect on hematological neoplasms. The further encapsulation of NM/NM-Pro in liposomes allows the sustained release of the drug and prolongs the residence time in vivo. Here, we prepared stable liposomes with a uniform particle size of 170.6±2.2 nm. The optimal ratio of NM to NM-Pro in this study was 2:1. The active drug NM in the NM/NM-Pro system continuously stimulated ROS production by the cells, which in turn further activated the NM-Pro to continuously generate NM. The positive feedback pathway between the NM and NM-Pro resulted in the specific death of tumor cells. Furthermore, the K562 hematological neoplasm model was utilized to evaluate the therapeutic effect of NM/NM-Pro liposomes in vivo. After encapsulation in liposomes, the targeting of tumor cells was increased approximately two times compared with that of normal cells, and NM/NM-Pro liposomes exhibited reduced toxicity, without an increase in drug activity compared to the NM/NM-Pro combination. The NM/NM-Pro delivery system exerts a positive feedback effect on ROS production in tumor cells and displays good potential for the specific killing of hematoma cells.


The concave urban space, a morphological innovation that dominated the European Modern Age, has an extensive historiography and numerous identifiable types: the Spanish plaza mayor, the French place royale, or the English squares. However, not enough attention has been paid to the examples of cities that did not succeed in implementing these plans, or to the alternative models that emerged from the oppositions they encountered on the ground. This is why the case of Seville and its Plaza de San Francisco, in apparent conflict with a general history of public space, is presented here — it shows, distinct from the plaza mayor, specifically the emergence of a city project based on the initiative of the private owners, with the connivance of the urban planning authorities. By consulting primary sources, a historical development of these processes is established as well as their consequences for the contemporary city.


Tea domain ontology was constructed and an ontology-based text classifier named DocOnto was implemented based on classes of concept in Protege.In the experiment,tea texts,wine texts and pizza texts were respectively classified to their corresponding categories by DocOnto,and the experimental results comparisons were also made between DocOnto and Naive Bayes.It shows that at the equivalent level of comprehensive precision,DocOnto can improve the recall effectively and get the higher F1 index.


The Isopoda species belonging to the Cymothoidae family are found parasitizing the body surface, fins, oral cavity and gill of fish, feeding on blood, mucus, epithelial and subcutaneous tissue. In the Brazilian Amazon there are few studies on the distribution of these parasites and their hosts. Thus, the objective of this study was to identify the Isopoda species occurring in S. altispinis collected in Brazilian Amazon floodplain lakes. It was examined the outer surface of the body, fins, buccal and branchial cavity, inner wall of the operculum and openings in the abdomen of 60 S. altispinis. The individuals found were collected with fine brushes, stilletto, tweezers and fixed and preserved in ethanol 70 ° GL with 10% glycerin. There were identified two species parasitizing the gills: 16 individuals of Anphira branchialis, Thatcher, 1993, with a prevalence of 13.33% and an individual of Vanamea symetrica (Van Name, 1925) with a prevalence of 1.67%. The data obtained in this study increase the knowledge of the parasitic species in S. altispinis, being reported two new occurrences of A. branquialis and V. symetrica in a new host.


In the formulation of any sociological problem it is preferable to start from certain basic premises and arrive at a logically consistent theoretical framework which would enable a rigorous and comprehensive understand ing of the empirical social reality in terms of the coordinates of space, time and object. For a proper study of social movements and social change these premises are :


The purpose of this paper is to investigate retail site selection criteria in community centers and ascertain the implications of these criteria for the retail real estate developer. Historically, real estate developers contemplating the development of a community center will acquire a site based on hunches, experience, and a limited amount of data. Real estate academics, on the other hand, have produced numerous mathematical models and methods for retail site selection. However, to the real estate developer the retail community shopping center has remained elusive. Not only will developers oftentimes face the prospect of site selection without a complete picture of who their tenants will be, but they will be left to their own experience to understand in depth the needs and preferences of typical community center tenants. This paper will explore current methods and site selection criteria used by leading community center tenants for site selection and will investigate how that information can be implemented by the developer to improve the ir approach to retail site selection. Thesis Supervisor: Brian A. Ciochetti Title: Professor of the Practice of Real Estate


The Swiss Authority decreed several provisions after the Fukushima event. Due to these provisions many examinations and safety increasing measures had to be done in a very short time. The result is the use of safety systems to show the control of Fukushima like events which were originally designed for other special events like aircraft crashes or explosion pressure waves. At the end of such ad-hoc measure the safety systems and the events controlled by using these functions are mixed up. Another effect of these ad-hoc measures is the prohibition of larger safety improvements with a concept that fits to the existing safety concept of the power plant. INTRODUCTION TO THE POWER PLANT


A new series of oxime ethers 4a–z was designed and synthesized to test the blocking activity against β1 and β2-adrenergic receptors. Docking of these ether derivatives into the active site of the identified 3D structures of β1 and β2-adrenergic receptors showed MolDock scores comparable to those of reference compounds. Biological results revealed that the inhibition effects on the heart rate and contractility are less than those of propranolol. Nevertheless, the two compounds 4p and 4q that displayed the highest negative MolDock score with β2-adrenergic receptors showed β2-antagonistic activity by decreasing salbutamol relaxation of precontracted tracheal strips, which indicates the importance of a chlorothiophene moiety in the hydrophobic region for best complementarity with β2 receptors. On other hand, the presence of a homoveratryl moiety increases the MolDock score of the tested compounds with the β1 receptor.


A rotating core magnetorheological finishing process has been developed to finish the external cylindrical surfaces at nano-level as the conventional finishing processes like grinding cannot meet the extreme precise requirement. The quality of finished cylindrical components estimated through its geometrical accuracy, material assets, and mechanical features. The macaroni making machine driving shaft is made up of mild steel where high quality of surface finish is required. In plastic toy industries, the mild steel punches are used where a high level of surface finish is required to increase the appearance of the products and to improve its geometrical accuracy. The MR finishing process can improve the external surface quality of the cylindrical components very precisely. This result in the improvement of prolongs functional performance of the components. In the present work, the optimum process parameters are experimentally investigated for nano-finishing of the mild steel cylindrical external surfaces using the rotating core magnetorheological (MR) finishing process. The rotation of tool core, the rotation of the cylindrical workpiece, the current, and the working gap are the control process parameters which affect the finishing performance i.e. percentage change in surface roughness value. So, the effects of these process parameters on the process response such as percentage change in surface roughness value have been analyzed using signal-to-noise ratios and mean response data. The current and the rotational speed of the tool core have been found as a considerable role for increasing the percentage change in roughness value. Further, the optimum magnitude of the process parameters are predicted as the current 3A, the rotational speed of tool 500 rpm, the rotational speed of the cylindrical workpiece 80 rpm and the working gap of 0.6 mm. With the finishing of these optimum process parameters on the present developed process, the average roughness Ra value of the external surface of the mild steel cylindrical is reduced to 60 nm from the initial Ra value of 600 nm in 90 minutes of finishing. The results of scanning electron microscopy test, mirror images and roughness graphs of the finished surface have confirmed that the present finishing process can fulfil the extreme precise requirement of surface quality which is not possible by the conventional finishing processes. The extreme precise requirement of the surface quality of the external cylindrical workpieces are dealing with mild steel punches in plastic toy industries, dies, and molds, macaroni making driving shafts, armature shaft, and shafts used in gear etc.


This paper focuses on making the library handbook as a means of promotion in the public library's youngest mountain. The purpose of this research is to create a handbook of Gunung Bungsu Public Library (PUGB) for the benefit of PUGB and librarians. Data were collected through documentation study, observation and interviews in the PUGB. The handbook is a guide or reference books in conducting activities in the library. The handbook can be used as a tool to facilitate the public to get information about libraries and library collections since the guidebook contains important information about the library. Collection of data and information in making the handbook conducted by ducumentation and observation. The first step in making  handbook is the collection of data and information. Further preparation of the organizational framework. The conteats of the framework are is: a preface, table of contents, overview, vision, mission, functions and objectives, opening hours, membership, order, plan room, system service, type of service, procedure utilization, regulaion borrowing, lending procedures, the procedure returns, sanctions, classification pf library materials, documents call number, classification collection, browse, catalog description, Wi-Fi, e-mail, and cover. The final step in the handbook  is making the cover of the . The handbook cover of the book is designed by using the software CorelDraw X5. Keyword s : handbook; library


Radiofrequency thermocoagulation has been used to treat chronic pain since the 1950s. The Tew electrode was developed as a flexible, curved electrode, virtually eliminating complication. Different temperatures and treatment durations were used to analyze the size and shape of lesions produced by the Tew electrode to facilitate the use of radiofrequency in chronic pain management.


2898 T-Cell Immunoglobulin and Mucin Domain 4 (TIM-4) Signaling in Innate Immune-Mediated Liver Ischemia-Reperfusion Injury (IRI). H. Ji, Y. Liu, Y. Zhang, X. Shen, F. Gao, R. Busuttil, J. Kupiec-Weglinski. Dept of Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA. Background: TIM-4, the only TIM protein not expressed on T cells, is found on macrophages and dendritic cells. As an innate immunity-driven local infl ammation response, we hypothesized that TIM-4 signaling may play a role in the mechanism of liver IRI. Methods&Results: Unlike in sham controls, the ischemia insult triggered TIM-4 mRNA expression in mouse livers subjected to warm ischemia (90min) and reperfusion (0-24h). Its levels increased progressively, peaking by 6h of reperfusion, and declining at 12-24h. TIM-4 expression correlated with the kinetics of hepatocellular damage (sALT levels), and macrophage infi ltration/activation, both peaking at 6h of reperfusion. Indeed, TIM-4 KO or WT (B/6) mice treated with antagonistic TIM-4 mAb (RMT4-53; 0.5 mg i.v. at -1h) were resistant against liver IRI, as shown by sALT levels, hepatic architecture (no edema, vacuolization/ necrosis), and Suzuki's histological score. Unlike in controls, TIM-4 blockade/ ablation decreased hepatic CD68+ macrophage sequestration. Although TLR2, TLR4, and TLR9 were all induced in Ig-treated IR-stressed livers, their levels were suppressed in TIM-4 KO groups, along with diminished pro-infl ammatory cytokines (TNF-α, IL-1β, and IL-6). To document the function of TIM-4+ macrophages, we have developed a new model of liver IRI in which CD11b-DTR mice were adoptively transferred with syngeneic bone marrow macrophages (BMM; 5x106 cells i.v. at day -1). After DT treatment at day -2 (circulating CD11b <0.2%), CD11b-DTR mice remained uniformly IR-resistant, compared with PBS-controls. Interestingly, unlike WT BMM, which recreated liver IRI after adoptive transfer in CD11b-DTR test mice, infusion of TIM-4-defi cient BMM failed to trigger IRI, as shown by diminished sALT levels, well-preserved liver architecture, and decreased Suzuki's histological score. Of note, consistently heightened TNF-α, IL-1β, and IL-6 levels in CD11b-DTR mice repopulated with TIM-4 profi cient (WT) BMM were diminished after infusion of TIM-4 defi cient (KO) BMM. Conclusion: This study provides new evidence that: 1) IR-stressed liver macrophages express TIM-4; 2) Disruption of TIM-4 signaling ameliorates liver IRI; and 3) TIM-4 signaling is critically required for macrophage activation in the mechanism of liver IR-damage. Hence, modulation of physiological TIM-4 expression provides the basis for novel therapeutic strategies against organ IRI in transplant recipients. Abstract# 2899 Netrin-1 Is a Novel Molecule That Elicits Chemoattraction of Activated CD4+ T-Lymphocytes Via Interactions With Neogenin. L. Boneschansker,1 S. Bruneau,1 H. Nakayama,1 J. Yan,2 E. Wong,2 D. Irimia,2 M. Klagsbrun,1 D. Briscoe.1 1Boston Children's Hospital, Boston; 2Massachusetts General Hospital, Boston. Netrin-1 is a chemotropic protein that elicits both attractive and repulsive migratory responses, depending on target cell receptor expression. Netrin-1 is expressed in several tissues, including the kidney, and functions in the immune system as a chemorepellent for neutrophils and macrophages. However, the effect of Netrin-1 and its attractive (Neogenin, DCC) and repulsive (UNC5A-D, DSCAM) receptors in T cell biology is poorly understood. We hypothesize that attractive and inhibitory Netrin-1 receptors are expressed on T cells depending on their state of activation. We initially profi led all Netrin-1 receptors by qPCR and found that human CD4+ T-cells express Neogenin, UNC5A and UNC5B at low levels. We found a timedependent increase in Neogenin expression (average 6-fold) following 6-48hr mitogen activation (anti-CD3/CD28). CD4+ T cells do not express UNC5C-D, DCC or DSCAM. Western blot analysis showed Neogenin, UNC5A and UNC5B proteins expression on unactivated CD4+ T cells; only Neogenin increased in expression following activation. Also, in preliminary FACS analyses, we fi nd Neogenin expression on ~60% of the CD4+CD25+ T cell subset. The functional effect of Netrin-1 on lymphocyte migration in vitro was evaluated using microfl uidics. A total of 39.7±5.0% of 48hr mitogen-activated CD4+ T cells respond to Netrin-1 (100ng/ mL), vs. 22.0±2.3% in media alone (P<0.01); chemoattraction occurs in 21.5±2.1% and chemorepulsion in 18.2±3.0% of cells. As a control, we found that Netrin-1 inhibited IL-8-dependent migration of human neutrophils (by ~40%; P<0.05). To test the in vivo function of Netrin-1, we transplanted human skin onto SCID/Beige mice and, after 6 wks, we humanized the mice by adoptive transfer of human PBMC. Following transfer, matrigel without or with Netrin-1 (5ug) was injected into the skin (n=8 mice). Focal leukocyte infi ltrates were observed in controls; Netrin-1 elicited a diffuse infl ammatory response with an overall ~1.5 fold increase in infi ltrates by day 14 (vs. controls, P<0.01). Collectively, these novel fi ndings defi ne Netrin-1 as a potent regulator of bidirectional human CD4+ T cell migration, and suggest that its chemoattractant effects are dependent on Neogenin. These fi ndings provide for the intriguing possibility that targeting Neogenin will convert Netrin-1 into a potent chemoinhibitor of activated CD4+ T cell migration. 2899 Netrin-1 Is a Novel Molecule That Elicits Chemoattraction of Activated CD4+ T-Lymphocytes Via Interactions With Neogenin. L. Boneschansker,1 S. Bruneau,1 H. Nakayama,1 J. Yan,2 E. Wong,2 D. Irimia,2 M. Klagsbrun,1 D. Briscoe.1 1Boston Children's Hospital, Boston; 2Massachusetts General Hospital, Boston. Netrin-1 is a chemotropic protein that elicits both attractive and repulsive migratory responses, depending on target cell receptor expression. Netrin-1 is expressed in several tissues, including the kidney, and functions in the immune system as a chemorepellent for neutrophils and macrophages. However, the effect of Netrin-1 and its attractive (Neogenin, DCC) and repulsive (UNC5A-D, DSCAM) receptors in T cell biology is poorly understood. We hypothesize that attractive and inhibitory Netrin-1 receptors are expressed on T cells depending on their state of activation. We initially profi led all Netrin-1 receptors by qPCR and found that human CD4+ T-cells express Neogenin, UNC5A and UNC5B at low levels. We found a timedependent increase in Neogenin expression (average 6-fold) following 6-48hr mitogen activation (anti-CD3/CD28). CD4+ T cells do not express UNC5C-D, DCC or DSCAM. Western blot analysis showed Neogenin, UNC5A and UNC5B proteins expression on unactivated CD4+ T cells; only Neogenin increased in expression following activation. Also, in preliminary FACS analyses, we fi nd Neogenin expression on ~60% of the CD4+CD25+ T cell subset. The functional effect of Netrin-1 on lymphocyte migration in vitro was evaluated using microfl uidics. A total of 39.7±5.0% of 48hr mitogen-activated CD4+ T cells respond to Netrin-1 (100ng/ mL), vs. 22.0±2.3% in media alone (P<0.01); chemoattraction occurs in 21.5±2.1% and chemorepulsion in 18.2±3.0% of cells. As a control, we found that Netrin-1 inhibited IL-8-dependent migration of human neutrophils (by ~40%; P<0.05). To test the in vivo function of Netrin-1, we transplanted human skin onto SCID/Beige mice and, after 6 wks, we humanized the mice by adoptive transfer of human PBMC. Following transfer, matrigel without or with Netrin-1 (5ug) was injected into the skin (n=8 mice). Focal leukocyte infi ltrates were observed in controls; Netrin-1 elicited a diffuse infl ammatory response with an overall ~1.5 fold increase in infi ltrates by day 14 (vs. controls, P<0.01). Collectively, these novel fi ndings defi ne Netrin-1 as a potent regulator of bidirectional human CD4+ T cell migration, and suggest that its chemoattractant effects are dependent on Neogenin. These fi ndings provide for the intriguing possibility that targeting Neogenin will convert Netrin-1 into a potent chemoinhibitor of activated CD4+ T cell migration. Abstract# 2900 Nrf2 Regulates TLR4 Innate Infl ammatory Responses Via Akt/Foxo1 Signaling Network. J. Huang, S. Yue, B. Ke, J. Zhu, X. Shen, Y. Zhai, R. Busuttil, J. Kupiec-Weglinski. Dumont-UCLA Transplant Ctr. Dept. of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA. Background: The nuclear factor erythroid 2-related factor 2 (Nrf2), a key regulator of resistance to oxidative stress, maintains the cellular redox homeostasis. Forkhead box O (Foxo) transcriptional factors modulate cellular processes in response to oxidative stress. Aim: We investigated molecular mechanisms by which Nrf2 regulates TLR4driven innate infl ammation in the pathogenesis of hepatic ischemia-reperfusion injury (IRI). Methods & Results: C57BL/6 wide-type (WT) and Nrf2-defi cient (KO) mice (n=4-6/gr) were subjected to partial hepatic warm ischemia (90min) followed by reperfusion (6h). Activation of Nrf2 after preconditioning of WT recipients with cobalt protoporphyrin (CoPP) ameliorated liver IRI, evidenced by improved hepatocellular function (sALT levels) and preserved tissue architecture (histology Suzuki's score). In marked contrast, ablation of Nrf2 signaling exacerbated IRinduced liver infl ammation and damage in Nrf2 KO hosts, irrespective of adjunctive CoPP preconditioning. CoPP-induced Nrf2-specifi c activation reduced macrophage/ neutrophil traffi cking, pro-infl ammatory cytokine programs, and hepatocellular necrosis/apoptosis, while increasing anti-apoptotic functions in IR-stressed livers. At the molecular level, Nrf2 activation augmented HO-1 expression and Stat3 phosphorylation, promoted PI3K/Akt while suppressing Foxo1 signaling. In contrast, Nrf2 defi ciency diminished PI3K/Akt and enhanced Foxo1 expression in the ischemic liver lobes. In parallel in vitro studies, Nrf2 knockdown in LPS-stimulated bone marrow-der


Resistive heating or electrothermal regeneration is a valuable alternative to conventional adsorbent regeneration methods because of cost, energy, and time efficiency; however, it only works for electrically conductive adsorbents such as activated carbon. Zeolites are widely used adsorbents for gas separation; however their high resistivity prevents their regeneration with resistive heating. This paper describes a proof of concept study assessing the feasibility and performance of multiple carbon loading techniques to decrease zeolite resistivity and allow its resistive heating without sacrificing its adsorption properties. Carbon was added to zeolite by physical mixing, chemical vapor deposition of ethanol and benzene, carbon nanotube growth via catalytic CH4 decomposition, and thermal decomposition of polyvinyl-alcohol. Similar thermal conditions were applied (2 hours at 600 °C) for all carbon deposition methods to avoid the impact of multiple variables. Elemental analyses and scanning electron micrographs confirmed the addition of carbon, and resistivity decreased by up to 8 orders of magnitude. Resistivity decrease was greatest when carbon was added directly to the zeolite's surface compared to physical mixing with zeolite. Carbon nanotube growth decreased zeolite resistivity from >107 Ω m to 0.7 Ω m, but caused partial loss of adsorption capacity. The reduction in zeolite resistivity, however, allowed resistive heating of zeolite at a heating rate as high as 120 °C min−1. This work presents CNT-addition as a potential method to allow resistive heating for zeolite adsorbent regeneration. By considering multiple carbon addition methods and identifying CNT-addition as preferred, these findings inform future research efforts that will focus on optimization and application testing.


We present Scratchy-a modular, lightweight robot built for low budget competition attendances. Its base is mainly built with standard 4040 aluminium profiles and the robot is driven by four mecanum wheels on brushless DC motors. In combination with a laser range finder we use estimated odometry - which is calculated by encoders - for creating maps using a particle filter. A RGB-D camera is utilized for object detection and pose estimation. Additionally, there is the option to use a 6-DOF arm to grip objects from an estimated pose or generally for manipulation tasks. The robot can be assembled in less than one hour and fits into two pieces of hand luggage or one bigger suitcase. Therefore, it provides a huge advantage for student teams that participate in robot competitions like the European Robotics League or RoboCup. Thus, this keeps the funding required for participation, which is often a big hurdle for student teams to overcome, low. The software and additional hardware descriptions are available under: https://github.com/homer-robotics/scratchy.


FIELD: industrial organic synthesis. SUBSTANCE: titaniumcontaining catalytic composition is prepared by liquid-phase impregnation of silicon-containing solid with titanium halide, for instance with titanium tetrachloride, in hydrocarbon solvent followed by calcination. Further, catalyst is optionally brought into interaction with water and/or silylating agent. EFFECT: improved working characteristics of catalyst and increased yield of epoxy products. 34 cl, 3 tbl, 9 ex


Abstract When a woman in a forty-two year old lesbian relationship becomes disabled, her partner becomes her primary caretaker. However, when the caretaker becomes ill, distant family members take over decision-making responsibilities and without regard to their wishes, separate the women in two different nursing homes. A lesbian social worker realizes the nature of the relationship and advocates with the respective families to have the two women placed together shortly before one partner dies.


A reply to:Assi, A. 2016. "Lebanon's consociational model, Christian parties and the struggle for political power in post-2005 period". Global Discourse 6 (4). http://dx.doi.org/10.1080/23269995.2016.1259230.


Infection with Mycobacterium tuberculosis remains a major global health emergency. Although detailed understanding of the molecular events of M. tuberculosis pathogenesis is still limited, recent genetic analyses have implicated specific lipids of the cell envelope as important effectors in M. tuberculosis pathogenesis. We have shown that pcaA, a novel member of a family ofM. tuberculosis S-adenosyl methionine (SAM)-dependent methyl transferases, is required for α-mycolic acid cyclopropanation and lethal chronic persistentM. tuberculosis infection. To examine the apparent redundancy between pcaA and cmaA2, another cyclopropane synthetase of M. tuberculosis thought to be involved in α-mycolate synthesis, we have disrupted thecmaA2 gene in virulent M. tuberculosis by specialized transduction. Inactivation of cmaA2 causes accumulation of unsaturated derivatives of both the methoxy- and ketomycolates. Analysis by proton NMR indicates that the mycolic acids of the cmaA2 mutant lacktrans-cyclopropane rings but are otherwise intact with respect to cyclopropane and methyl branch content. Thus,cmaA2 is required for the synthesis of thetrans cyclopropane rings of both the methoxymycolates and ketomycolates. These results define cmaA2 as atrans-cyclopropane synthetase and expand our knowledge of the substrate specificity of a large family of highly homologous mycolic acid methyl transferases recently shown to be critical toM. tuberculosis pathogenesis.


Microcosm is an example of a virtual world, providing long-term, primarily (but not exclusively) synchronous communication among large, distributed communities, whose members are represented by virtual identities known as avatars. It provides support for establishing an identity, social interaction, navigation, interacting with objects, customization and extensibility, and security.


Disclosed is a process for the flame signal detection by means of a projecting into a combustion chamber of a burner flame rod (15), comprising the steps of: detecting a first signal, the effluent of one of the ionization electrode (15) ionisation current is dependent, generating a second signal indicative of a predetermined having cyclical pattern, generating a third signal by adding the first signal and the second signal, comparing the third signal with a first threshold value and generating a fourth signal based on the comparison of the third signal with the first threshold value, comparing the third signal with a second, from the first threshold value different threshold value, and generating a fourth signal based on the comparison of the third signal with the second threshold value, and determining an operating parameter of the burner on the basis of at least one of the fourth signal and the fifth signal. In addition, a corresponding device for flame signal detection is proposed.


How can we spot anomalies in large, time-evolving graphs? When we have multi-aspect data, e.g. who published which paper on which conference and on what year, how can we combine this information, in order to obtain good summaries thereof and unravel hidden anomalies and patterns? Such multi-aspect data, including time-evolving graphs, can be successfully modelled using Tensors. In this paper, we show that when we have multiple dimensions in the dataset, then tensor analysis is a powerful and promising tool. Our method TENSORSPLAT, at the heart of which lies the "PARAFAC" decomposition method, can give good insights about the large networks that are of interest nowadays, and contributes to spotting micro-clusters, changes and, in general, anomalies. We report extensive experiments on a variety of datasets (co-authorship network, time-evolving DBLP network, computer network and Facebook wall posts) and show how tensors can be proved useful in detecting "strange" behaviors.


In this article we describe an implementation of the Mehrotra's primal–dual interior-point method in the package . Usage of 's computer algebra system in our software is described. Both augmented and normal equation system approach are implemented. Described implementation is compared with main LP solvers. Algorithm for generating an efficient starting point as well as algorithm for the elimination of zero variables and the stabilization algorithm are incorporated in the developed code.


Amy Snyder Ohta (1962– ) is best known for her application of Vygotsky's sociocultural theory to second language learning and development. She is also widely recognized as one of the first scholars who conducted extensive research on the development of interactional competence of adult learners of Japanese through microanalysis of classroom interactions.

Keywords:

language and social interaction;
language in the class room;
pragmatics;
sociocultural language studies


With the rapid development of Internet economy, the problem of "last kilometer" distribution difficulty in B2C e-commerce has become one of the pain points of the whole industry, and improving the customer service level of C-end has become an important content of enterprise development. The change of C-end demand distribution will have a significant impact on the location of end-of-line service outlets, so this paper studies the spatial distribution of C-end customer demand points. According to the significant spatial clustering of C-end customer demand points in geographical space, K-means algorithm and DBSCAN algorithm are selected to cluster the demand points. The clustering results of the two algorithms are evaluated by the internal distance and the average distance between clusters. The comparison results show that k-means algorithm has better clustering effect on the demand points, and its clustering results can also be used as the end the main measurement index of service network layout provides services for terminal service network location.


Objective To discuss a new method of BMSCs culture which can reduce the lead-in of extraneous antigenic substances in the process of cell culture, and can thus better meet the demand on the quantity and biological characteristics of BMSCs in the clinical use of tissue engineering bone. Methods BMSCs from a human adult in vitro were induced by using autologous platelet-rich plasma instead of animal serum in high-carbohydrate DMEM (Dulbecco's minimum essential medium). After the cultured BMSCs were amplified rapidly by Rotary Cell Culture System, their growth status was observed and their biological characteristics were detected. Results The cells were in good growth status and presented fine biological characteristics. Their growth speed in Rotary Cell Culture System was observed to be evidently faster than that by conventional methods. Conclusions Rotary Cell Culture System by autologous platelet-rich plasma instead of animal serum is a good culture method to induce human BMSCs in vitro. The quantity and biological characteristics of BMSCs cultured in this way can meet the demand in clinical use.


A third of Americans have hypertension, a major antecedent of stroke and heart failure. A single bout of exercise lowers blood pressure in hypertensive humans (postexercise hypotension, PEH). There is evidence suggesting exercising muscle releases substance P (SP) in the NTS to depress baroreflex function by decreasing NTS baroreceptor output to distal synapses via activating GABA signaling. We previously showed that a SP neurokinin receptor (NK1R) antagonism in the NTS attenuated PEH. We further showed that PEH was associated with a decrease in GABA inputs to NTS 2nd‐order baroreceptor neurons that was normalized with NK1R antagonism. Here we tested the hypothesis that reduced available NK1R on GABAergic inter neurons in the NTS contributes to the exercise‐induced reduced GABA inputs. NK1R distribution on glutamic acid decarboxylase (GAD 67) positive neurons was examined using fluorescent immunohistochemistry. We confirmed that activation of the NK1R with SP resulted in NK1R internalization in the NTS. The GABA neurons from the PEH group had a higher degree of NK1R internalization compared to the SHAM group. The data suggest that NK1R internalization may contribute to the exercise‐induced decrease in GABA inputs to the NTS 2nd‐order baroreceptor neurons during PEH. These results provide a potential novel target for treating hypertension.


The formation and development situation of Chinese woodworking machinery distributors are introduced systematically for the first time.The current status of Chinese woodworking machinery distributors are analyzed and the fact that Chinese woodworking machinery distributors are a team that can't be ignored,for it helps promote the development of China's forest industry and regulate the market and promote industrial development in the current market economy,is pointed out.


The nearest-neighbor diffusion-based algorithm (NNDiffuse) has seen great success in multispectral pansharpening. Here, we extend the capabilities of NNDiffuse to perform image fusion of high-res multispectral and low-res hyperspectral images (HRMSI+LRHSI fusion). Unlike learning-based frameworks which are computationally expensive and require extensive optimization and/or training time, NNDiffuse is fast, radiometrically accurate (introduces less spectral distortions compared to other state-of-the-art methods), and requires no training data. We introduce the utility of NNDiffuse in hyperspectral-panchromatic and hyperspectral-multispectral sharpening and look at workflows dealing with low-res HSI bands that fall outside the HRMSI spectral response functions. Sharpened image quality is assessed using image-wide metrics. Sharpening performance is also measured on the fused images in terms of their utility in pixel classification and ACE target-background separability. NNDiffuse and DL- and non DL-based methods are presented using hyperspectral imagery from SHARE2012, AVIRIS-NextGen, Hyperspec-VNIR-C, and ROSIS sensors.


Measurements of the network bandwidth is a fundamental issue in the area of networking analysis. Hence, a great deal of research should be conducted for evaluating and understanding of network measurements since it is crucial and useful in many areas of enhancing network performance including; protocol development, evaluate network changes and discover of the network problems. This paper is concerned with the analysis of bandwidth measurements A scheme for detecting and identifying of network problems by measuring the characteristics of network bandwidth is proposed. The proposed approach is applied on the network infrastructure at the Hashemite University-Jordan (HU) as a case study. The network bandwidth is analyzed in terms of upload/download measurements where these two variables are extracted from the main university network gateway. The results are incorporated in the proposed approach to identify the university network problems. Furthermore, a formula describing internet traffic and the other sources of traffic is introduced and proved by using the outcome of monitoring the bandwidth on firewall gateway. The presented scheme is shown for its ability to, successfully, identifying and accordingly correcting the main weaknesses and shortcomings of the targeted network.


The oil and gas industry is in a stage of intense focus on safety, preparing for better management of environmental risks and mitigating them. Given the policy of corporate social responsibility, technical and economic challenges, as well pressures in domain-specific regulations, it has become increasingly obvious that the management of these risks is essential for long-term sustainability of oil and gas companies. Research shows that safety and environmental issues, compliance with regulatory rules, price volatility, and rising challenges associated with access to oil and gas reserves and markets are the top risks identified by oil and gas industry executive directors. In this sense, the tools offered by artificial intelligence can contribute to the proper management of these risks and to the adequate monitoring of all the categories of processes that take place at the level of the optimized production generated by the gas wells, regarding the transport of petroleum products through the pipelines and especially with regard to offshore activities.