In the coming decades, the proportion of wind–solar energy in power system significantly increases, resulting to uncertainties of power fluctuation in abundant wind–solar energy regions. The flexibility operation of Pumped Storage Power Plants (PSPPs) has already been widely recognized to regulate wind–solar power fluctuations; however, less is known about the regulation reliability of the PSPP affected by them. It is a challenge, since various uncertainties exist during this regulation process. Here, a mathematical model with a solar–wind–hydro hybrid power generation system is adopted to investigate the regulation reliability of PSPP. The uncertainties and limitations of model parameters are considered during this process. Five regulation indexes, i.e., rise time, settling time, peak value, peak time and overshoot of the reactive power generator terminal voltage, guide vane opening and angular velocity, are extracted to evaluate the PSSP's regulation quality. Finally, the PSPP reliability probability affected by parametric uncertainties is presented. The obtained results show that the inertia coefficient is the most sensitivity parameters for the settling time, peak value and peak time with sensitivity index 33.7%, 72.55% and 71.59%, respectively. The corresponding total contribution rate of the top 10 sensitive parameters are 74.45%, 93.45% and 87.15%, respectively. Despite some types of uncertainties not being considered, the results of this research are important for the regulation reliability evaluation of PSPPs in suppressing power fluctuations of wind and solar generation.


The mode of Na+ entry and the dynamics of intracellular Na+ concentration ([Na+]i) changes consecutive to the application of the neurotransmitter glutamate were investigated in mouse cortical astrocytes in primary culture by video fluorescence microscopy. An elevation of [Na+]i was evoked by glutamate, whose amplitude and initial rate were concentration dependent. The glutamate‐evoked Na+ increase was primarily due to Na+‐glutamate cotransport, as inhibition of non‐NMDA ionotropic receptors by 6‐cyano‐7‐nitroquinoxiline‐2,3‐dione (CNQX) only weakly diminished the response and d‐aspartate, a substrate of the glutamate transporter, produced [Na+]i elevations similar to those evoked by glutamate. Non‐NMDA receptor activation could nevertheless be demonstrated by preventing receptor desensitization using cyclothiazide. Thus, in normal conditions non‐NMDA receptors do not contribute significantly to the glutamate‐evoked Na+ response. The rate of Na+ influx decreased during glutamate application, with kinetics that correlate well with the increase in [Na+]i and which depend on the extracellular concentration of glutamate. A tight coupling between Na+ entry and Na+/K+ ATPase activity was revealed by the massive [Na+]i increase evoked by glutamate when pump activity was inhibited by ouabain. During prolonged glutamate application, [Na+]i remains elevated at a new steady‐state where Na+ influx through the transporter matches Na+ extrusion through the Na+/K+ ATPase. A mathematical model of the dynamics of [Na+]i homeostasis is presented which precisely defines the critical role of Na+ influx kinetics in the establishment of the elevated steady state and its consequences on the cellular bioenergetics. Indeed, extracellular glutamate concentrations of 10 μm already markedly increase the energetic demands of the astrocytes.


In this article, we generalize the partially linear single-index models to the scenario with some endogenous covariates variables. It is well known that the estimators based on the existing methods are often inconsistent because of the endogeneity of covariates. To deal with the endogenous variables, we introduce some auxiliary instrumental variables. A three-stage estimation procedure is proposed for partially linear single-index instrumental variables models. The first stage is to obtain a linear projection of endogenous variables on a set of instrumental variables, the second stage is to estimate the link function by using local linear smoother for given constant parameters, and the last stage is to obtain the estimators of constant parameters based on the estimating equation. Asymptotic normality is established for the proposed estimators. Some simulation studies are undertaken to assess the finite sample performance of the proposed estimation procedure.


In 1937, several Japanese pearling vessels were arrested and seized by a patrol boat, operated by the Northern Territory Administration, because they had been found in territorial waters adjacent to an aboriginal reserve. At least eight actions were brought before Wells J. in the Supreme Court of the Northern Territory by the owners of the vessels in respect of these seizures. These actions resulted in two verdicts in favour of the Japanese owners, while the remainder were settled out of court, also in favour of the Japanese. The two judgments which were handed down by Wells J. are unreported, despite the widespread contemporary publicity given to the entire incident, and the importance of the issues which arose for consideration before the Court. Although it would be misleading to overstress the importance of the decisions as judicial precedents, they are nonetheless valuable and interesting because many of the issues which were considered by the Court are still relevant in the current controversy over offshore sovereignty in the Australian federal system. Although the High Court in December 1975 finally decidedl that the Commonwealth, as opposed to the States, has sovereignty over offshore areas beyond low water mark, the detailed application of this ruling still needs to be worked out, especially with regard to internal waters, offshore islands and islets, and waters enclosable by the application of the old common law rules. Several of the conclusions in these cases also provide some useful historical evidence of the law as it was understood at the time of the litigation.


Ç T HE IEEE Transactions on Software Engineering (TSE) and ACM Transactions on Software Engineering and Methodology (TOSEM) are jointly initiating a uniform approach to " journal-first " publication for the software engineering research community. The goal is to provide a mechanism whereby research results that may be a better fit for publication via the journal review process can be broadly disseminated to the community through presentation in the technical research tracks of ACM-and IEEE-sponsored conferences. As in other communities that provide a journal-first publication route (such as the VLDB conference in the database community), authors choosing this route benefit from the absence of page limits and annual submission deadlines, and the possibility of having their submissions undergo multiple rounds of review and revision. TSE and TOSEM are now considering manuscripts for review in a new submission category called Journal-First that can be selected in Manuscript Central at the time of submission. Authors of journal-first manuscripts will be required to declare that their paper qualifies for publication and presentation via the journal-first process. In short, journal-first manuscripts report research contributions that have not already been presented in prior publications. Papers that extend prior publications (particularly conference papers) by providing, for example, additional detail (proofs, algorithms, etc.) or expanded empirical evaluation that further supports the contributions of the prior publication would not qualify as journal-first. Papers that report completely new contributions or that build on prior work in substantial ways that lead to distinct and novel contributions beyond the prior work would qualify as journal-first. Ultimately, the community of reviewers and editors charged with assessing a submitted manuscript will judge whether a paper is sufficiently novel in its contributions to be considered journal-first; papers that do not qualify may be shifted to existing manuscript categories in TSE or TOSEM, and the authors will be so notified. Journal-first submissions to TSE and TOSEM will be reviewed using the same rigorous review process already in place for current submission categories, and in the same timely manner that the journals strive to maintain. Once a journal-first manuscript is accepted, it will be made available to organizers of upcoming software engineering conferences so that it may be included in a conference technical research track. TSE and TOSEM will actively promote all accepted journal-first papers for inclusion in conference programs for two years after their publication date. Conference organization is independent of TSE and TOSEM, so …


System and method for providing information in the system registry for accessing stored. The system and method further dynamic partitioning system registry general (applications and / or operating system independent) method is more convenient. The present invention also provides a user view such becomes more convenient for the client, components, and / or applications. Users may be based on the version, the computer configuration, the user and / or other suitable information. In addition, you can run the operating system's user registry view. Additionally and / or alternatively, that allow low-level components (e.g., client and / or application programs) to access dynamic partitioning to manipulate the data storage unit (e.g., add, delete and / or modify) redirection information (e.g., via an interface component).


A fitting method based on killing function specific explosion curves about missile in indicated plane of aircraft peripheral space is introduced. A geometric description of the threat of shot points on specific explosion curves by using the plane firing line scanning method was given and aircraft vulnerability was calculated according to concrete data of discrete shot points. By using kill probability caused by a series of discrete shot points and curve fitting to concrete data,the author fits a killing function satisfying some killing environment and conditions,which can be used to calculate any point's kill probability on continuous explosion curves plane of missile body on aircraft peripheral space.


The article proposes a new direction for the further development of GL-models–models on the basis of which performs the calculation of the reliability parameters of fault-tolerant multiprocessor systems. Such models reflect the reaction of the system to the appearance of failures of arbitrary multiplicity.The essence of the new direction is the construction of a model by composition of several basic GL-models in such a way that the values of the edge functions of onemodel form the input vector of the next one. This article shows that the model obtained in this way, which is proposed to be called cascade model, will also be basic and, in general case, can consist of an arbitrary number of submodels. This article givesa formula that allows one to determine the value of the degree of fault tolerance of the cascade model, depending on the values of the levels of fault tolerance of its component submodels. This article shows that the graphs of both the cascade and regularmodels are cyclic and have the same number of edges. At the same time, despite the fact that the intermediate submodels also have graphs, their presence does not increase the complexity of the model as a whole, since only the expressions of the edge functions are used in them. This article contains examples that confirm the correctness of the theoretically obtained results, and it also shows that the cascade model, at least in some cases, has lower computational complexity (the total number of logical operations in the expressions of edge functions) compared to the basic model. It was found that although the cascade model is basic, the sets of edges itloses and the regular basic GL-model on some input vectors may differ. In certain cases, several alternative cascade models can be built, which will differ in their parameters, but will have the same resulting value of the degree of fault tolerance.Given an example, where the properties of such alternative cascade models are compared. It was found that such models differ both in computational complexity and, in some cases, in the sets of edges they lose on certain input vectors. The possibility of modifying the cascade model was shown by changing the expressions of the edge functions of its component submodels, both individually and several simultaneously. At the same time, it is possible to block vectors with an increased multiplicity of zeros. A number of tasks for future research wereformulated.


Conventional magnetotelluric (MT) analyses of the Papua New Guinea (PNG) dataset reveal that it is a very good two-dimensional (2D) dataset with relatively high S/N ratios up to 10 2 s. However, traditional Swift's angles are unstable at some sites and differ slightly site to site. This implies that weak but significant distortions are present at all sites. Hence, the regional 2D strike angle was sought by minimizing the global X 2 misfits derived from the site- and frequency-independent Groom-Bailey (GB) decomposition at seven selected sites. The other three sites were eliminated by X 2 -test. The strike angle was determined to be 60° west of geographic north. One-dimensional (1D) Monte-Carlo inversion was performed using the Berdichevsky averages of the decomposed 2D principal tensor elements. The 2D model simply based on the 1D inversions was able to reproduce the observed impedances, except for the systematically high values of TM phase in the period range of 10 -1 to 10 s. This indicates that a 1D approximation of the electrical conductivity structure beneath this region is reasonably valid. The 1D models indicated the existence of a thin (up to 2.5 km) resistive layer just below the surface, suggesting the 'single' Darai limestone.


The present article gives coverage to conditionality of the modern range of problems of correlation between the phenomena of ''belief'' and ''knowledge'' from a perspective of the background (contradiction between realism and nominalism), as well as role and significance of the issue of ''existence'' of the non-existent thing conditioned by the irrational factor. The issue of possibility / impossibility of correlation between the reality and the abstracted and intuitive knowledge is considered. The reasons according to which different nominalistic and realistic interpretations of universals can only be conditionally called contradictory have been analyzed. In connection with the above-stated, the issue of possibility / impossibility of a single subject of all science was considered, as the nominal-real has a direct relevance to this; also the intentionality of cognition was analyzed, which in a certain way is related with abstracted and intuitive knowledge. The problem of existence of the non-existent thing is considered, it has irrational nature not only in terms of nominalism. Justification of the noniden-tity of universals and substances by means of impossibility of the latest to be part of utterances / reasoning once again indicates the necessity of parallelism of the phenomena: language reality. Elements of the phenomenological method are used in research. According to the causes analysis various nominalistic-realist interpretations of the universal can be called inconsistent only conditionally; the parallelism of phenomena ''language reality'' is determined by nonidentity of universals and substances. As knowledge is not an autonomous unchangeable system, there is a need to analyze the process of formation and further development of syllogistic reasoning. The fundamental problem of reality, not relevant to the creation, actualizes directly the phenomenological aspect of knowledge. This study is relevant in terms of the philosophy of science and theory of cognition; historical parallels specified in this article make it possible to explain the grounds of the inconsistence of the nominal-real in terms of the history of philosophy. The considered issue can also be of interest from the ontology discourse point of view, as the discourse of knowledge is constituted in a certain manner and a means of its expressing is a logical component, whereas non-logical components provide other means of discourse organization.


Abstract Monoclinic hydroxyapatite was synthesized by a wet method followed by heating in air at 1473 K for 1 h. The product is carbonate-free and has a Ca/P ratio of 1.65, which is slightly lower than the theoretical value (1.67) of hydroxyapatite. The crystal structure was investigated by Rietveld refinement using X-ray powder diffraction data. The structure has monoclinic symmetry with the space group P 2 1 / b (No. 14), Z =4, Dx =3.14 g cm −3 , and the lattice constants are a =9.426(3) A, b =18.856(5) A, c =6.887(1) A, and γ =119.97(1)°. The hydroxyl ions have an ordered arrangement along the hydroxyl columns. The hydroxyapatite prepared in the present study is 98% monoclinic.


c o r r e l a t i o n (or indeed any) w i t h s k i l l s i n v o l v e d i n gymnastics. T h i s i s borne out by Brace (26) who, i n a study of the l e a r n i n g a b i l i t y of high school g i r l s i n a s e r i e s of what he c a l l s "stunt type" a c t i v i t i e s , concluded t h a t the l e a r n i n g of sports type s k i l l s (mainly i n v o l v i n g b a l l s k i l l s ) i n v o l v e d d i f f e r e n t a b i l i t i e s from those r e q u i r e d to l e a r n s t u n t s ( t h a t i s gymnastic s k i l l s ) and rhythm type a c t i v i t i e s . He suggested, t h e r e f o r e , t h a t there must be d i f f e r e n t types of motor l e a r n i n g . 26. ( c ) The R e l a t i o n s h i p between Mental and Gross Motor A b i l i t y . I n a g e n e r a l study i n 1906 Terman suggested t h a t comparing "bright c h i l d r e n " w i t h "average c h i l d r e n " the b r i g h t c h i l d r e n performed b e t t e r on mental t e s t s but were I n f e r i o r I n motor t e s t s to the average c h i l d r e n . T h i s was the f i r s t of a s e r i e s of elementary s t u d i e s on t h i s s u b j e c t which were c a r r i e d out I n the f i r s t p a r t of the present century. These s t u d i e s produced v e r y c o n f l i c t i n g r e s u l t s , some agreeing w i t h Terman and others v i o l e n t l y d i s a g r e e i n g . These e a r l y r e s e a r c h e s are l i s t e d by O l i v e r (16) i n h i s s t u d i e s concerning e d u c a t i o n a l l y sub-normal boys. Perhaps the most important work f o r the purposes of the present study being t h a t of Nenzec, Cronin and Brannon i n 1933, who, i n v e s t i g a t i n g the r e l a t i o n s h i p between i n t e l l i g e n c e and motor a b i l i t y as measured by the Brace motor a b i l i t y t e s t s of normal g i r l s , found negative r e l a t i o n s h i p between I n t e l l i g e n c e and motor a b i l i t y and a s l i g h t but p o s i t i v e r e l a t i o n s h i p between c h r o n o l o g i c a l age and motor, a b i l i t y . B a l l a r d (27) d i s c u s s i n g the f i n d i n g s of American r e s e a r c h e r s up to 1919 i n s i s t e d t h a t they had found "a marked correspondence" between mental and motor a b i l i t y . However, he admitted t h a t t h e i r data was d e r i v e d from p r a c t i c a l sources and l a r g e l y from s u b j e c t i v e o b s e r v a t i o n s . B a l l a r d b e l i e v e d t h a t the American f i n d i n g s stemmed from the b e l i e f i n the p o s s i b i l i t y of f i n d i n g a "Motor Quotient" comparable w i t h I.Q,. I n 1925, Heaton (28) u s i n g an American sample of h i g h and low mental a b i l i t y and measuring height, weight, ches t expansion, 27. .75 yards dash, standing broad jump, a throw and push ups, found th a t those c h i l d r e n w i t h h i g h i n t e l l i g e n c e r a t i n g s were s u p e r i o r i n p h y s i c a l development to those having low i n t e l l i g e n c e r a t i n g s . I n h i s g e n e r a l conclusions he suggested two reasons f o r t h i s : • 1. The low mental a b i l i t y groups come from low income groups, and a r e , t h e r e f o r e , more l i a b l e to m a l n u t r i t i o n and i l l n e s s . 2. The more i n t e l l i g e n t t r y harder. Two s t u d i e s , by K i e l e r (29) and Johnson ( 3 0 ) , came to the common con c l u s i o n t h a t there was no s i g n of a s i g n i f i c a n t r e l a t i o n s h i p between p h y s i c a l s k i l l as measured and mental power or general x i n t e l l i g e n c e as measured. The Johnson t e s t s were used i n both r e s e a r c h e s as the measure of p h y s i c a l s k i l l . I n h i s r e s e a r c h Johnson claimed t h a t h i s t e s t b a t t e r y which c o n s i s t s of t e n a g i l i t y e x e r c i s e s performed on a 15 f o o t mat e l i m i n a t e d the elements of speed, s t r e n g t h and endurance, s k i l l alone being the f a c t o r considered. Johnson's r e s u l t s show a s l i g h t l y negative r e l a t i o n s h i p between mental a b i l i t y and h i s t e s t s (-0.059). These f i g u r e s are not s i g n i f i c a n t l y d i f f e r e n t from those of Ray (31) who i n studying the r e l a t i o n s h i p of Terman-Merrill T e s t r e s u l t s to t e s t s of p h y s i c a l a b i l i t y found r e l a t i o n s h i p s which ranged from 0.09 to 0.26 depending on the p h y s i c a l t e s t c o n s i d ered. Using a sample covering the whole range of a b i l i t y from s u p e r i o r to sub-normal K u l c i n s k i (32) i n 1945 concluded t h a t the average or normal group were s u p e r i o r to the sub-normal i n l e a r n i n g p h y s i c a l s k i l l s . X See "Tests and Measurements i n Health and P h y s i c a l Education", McCloy C.H. and Young N.D. Pages 95 to 98. 28. x The work of Dr. D.K. Brace i n t h i s f i e l d i s of the g r e a t e s t importance to the present study. Brace was p a r t i c u l a r l y a c t i v e i n the whole f i e l d of measuring motor a b i l i t y , working w i t h samples covering the whole range of mental a b i l i t y . I n one study he used a sample composed of low and h i g h grade mental d e f e c t i v e s w i t h I.Q.'s ranging from 23 to 82, w i t h a mean as low as 52.9, and i n another a sample co n t a i n i n g the h i g h e s t I.Q.'s a v a i l a b l e to him. I n v e s t i g a t i n g the r a t e of l e a r n i n g gross motor s k i l l s Brace (33) experimented w i t h the measurement of the speed of l e a r n i n g i n terms of the number of t r i a l s r e q u i r e d to master a s k i l l t e s t , and he found t h a t I.Q. was not a s i g n i f i c a n t f a c t o r i n the speed of l e a r n i n g the t e s t s . I n 1949 Brace (34) i n d i s c u s s i n g h i s experiment i n the motor-learning of f e e b l e minded g i r l s , made a summary of h i s own work on the r a t e of l e a r n i n g gross b o d i l y motor s k i l l s , and a l s o t h a t of McNeeley, McCloy and Milne. He concluded that i n the e d u c a t i o n a l l y subnormal range there was some r e l a t i o n s h i p between i n t e l l i g e n c e scores and the sco r e s i n the v a r i o u s p h y s i c a l t e s t s , but i n the normal population of c h i l d r e n and a d u l t s the c o r r e l a t i o n between i n t e l l i g e n c e and gross motor l e a r n i n g was approximately zero . Brace pointed out, however, t h a t even i n the e d u c a t i o n a l l y subnormal range the r e l a t i o n s h i p between the performance of motor s k i l l s and i n t e l l i g e n c e was too low to have ttny p r e d i c t i v e v a l u e . I n a l a t e r study u s i n g the Brace s c a l e w i t h young c h i l d r e n aged between 5 and 9 y e a r s , V i c k e r s (35) found t h a t a good score on X See "Measuring Motor A b i l i t y " , A.S. Barnes & Co, New York, 1927, and other r e f e r e n c e s i n present study.


A natural growth stimulant, triacontanol can be extracted from commonly grown alfalfa, which might be used as a growth promoter for seedlings. The objective of this study was to determine the effect of alfalfa crude extract on growth of J. procera seedlings. 15 g of equal mixed alfalfa leaves and shoots were soaked in one litter of tap water for 24 hrs, 36 hrs, 48 hrs, 60 hrs and 72 hrs. A 200 ml extract was applied on factorial arranged J. procera seedlings at 5 days, 10 days, 15 days and 20 days interval in Randomized Complete Block Design with 6 replications. J. procera seedling height and dry weight was significantly affected by soaking time and application interval. However, both the height and dry weight were not significantly affected by the interaction effects of soaking time and application interval of the alfalfa water extract. The results of the study have revealed that application of alfalfa water extract could be used as a growth promoter to increase seedling length and dry weight of the seedlings.


Three groups of welded joints,including circular butt welded joint without and with shot peening treatment and cross-plate welded joint,were adopted and their very high cycle fatigue behavior study was carried out by using ultrasonic fatigue testing technique in ambient air and at room temperature with a stress ratio R=-1.Experimental results show that fatigue strength of circular butt welded joint is much higher than that of cross-plate welded joint,and the fatigue strength of welded joint is improved by shot peening treatment.The comparison of fatigue strength between welded joint and its base material with corresponding joint shape shows that the fatigue property of welded joint is much lower than that of base metal.Under the condition of same fatigue life,the fatigue strength of circular butt welded joint is only 45% of base metal while that is only 29% of base metal for cross joint.Fracture can still occur at circular joint beyond 5×106 cycles,while cross joint has a fatigue limit at very high cycle region(107-109 cycles).The fracture surface analysis by scanning electron microscope shows that cracks mainly initiate from the welded toes at fusion area or geometric discontinuity at the surface of circular butt welded joint and initiate from welded toes in cross-plate welded joint.Furthermore,cracks may initiate from weld defects,including the surface of specimen or discontinuity site at fusion area.The influence of shot peening on the site of crack initiation is not significant.


'Thou hast done well: This is God Who hath brought thee here!' Īšān Tīmūr Hwāja (born 1948) to the author, summer village of Sang-i Milla-yi Bālā, district of Šahr-i Naw, Tajikistan, 10 August 2009 On the basis of a reconstruction of the careers of a variety of religious personnel of Islam in the Tajik Soviet Socialist Republic, from de-Stalinization to independence, this article aims to shed light on some neglected features of Islam in Soviet Central Asia. Questioning the present-day hagiographic process, and confronting the data of oral history with those of pre-modern Muslim hagiography and biographies of religious scholars, this article assesses the specific Islamic revival that has been taking place in Central Asia in the aftermath of the reopening of the Gulag in 1955–56. It also deals with the lasting Kulturkampf, engineered by the Soviet authorities, between the Fergana-born Uzbek-speaking accredited staff of the Muslim Spiritual Board on the one hand, and the Persian-speaking leaders of prominent Sufi lineages with Bukhara and Samarqand pedigrees on the other. The role of mass population transfers in this phenomenon is evoked through their impact on the disruption of the Sufi masters' sacred 'territories' (Persian: qalamraw), and the increasing role of the latter as community builders. Acting as alternative figures to pre-modern khans, the Soviet saints of Islam, who have become the objects of a rich hagiographic process, are also introduced as the bearers and transmitters of pre-modern court culture that vanished from Central Asia in the early 1920s. Special consideration is given to the mutual relationship and competition between the scholars ('ulama) of the Spiritual Board and the gnostics ('urafa) of the Sufi paths, as well as to the former's contribution to a revival of Turkic Islamic culture – notably through the comment of Chaghatay didactical literature within active, though underground, literary circles.


Objective To investigate the protective effect of sevoflurane postconditioning with different concentrations given at the onset of reperfusion on focal cerebral ischemic-reperfusion injury.Methods Fifty male SD rats were randomly assigned to five groups(with 10 rats each):control group,oxygen inhalation group and 0.5MAC,1.0MAC,1.5MAC sevoflurane postconditioning group.All animals were subjected to the right middle cerebral artery occlusion(MCAO) for 120min, followed by reperfusion for 72h.The animals in 0.5,1.0 and 1.5MAC group were given 0.5,1.0 and 1.5MAC sevoflurane inhalation from 20min before to 10min after reperfusion.The neurological deficit scores (NDS) were recorded at 24,48,and 72h after reperfusion.Infarct volume percentage was determined after the last NDS assessment.Results The infarct volume percentage ratio of 0.5,1.0 and 1.5MAC group were 0.39±0.03,0.31±0.03 and 0.24±0.03,respectively (P0.05, among the groups),which were significantly smaller than 0.53±0.05 in control group (P0.05).The infarct volume percentage of O2 group was 0.51±0.05,which was not significantly different with that of control group. NDS of 24,48h and 72h after reperfusion in all sevoflurane groups was significantly higher than that in control and oxygen groups.Conclusion 0.5,1.0 and 1.5MAC sevoflurane postconditioning has a significant neuroprotective effect in a dose-dependent manner.


This paper positions knowledge migrants in the context of cross-border migration. This type of migrants is often staying abroad on a temporary basis. This holds especially for young highly-skilled people who move to another country for enhancing their research skills or for educational purposes. The paper sketches the issues concerned and provides empirical information from a study on young temporary knowledge migrants to The Netherlands. It addresses in particular the motives and satisfaction of these young migrants.


Flood risk, a function of hazard, exposure, and vulnerability, is increasing globally and has led to more and more disastrous flood events. Previous research has shown that taking early action is much more cost-effective than responding once the flood occurs. Such an anticipatory approach requires flood early warning systems (EWS) that provide ample lead time and that have sufficient spatial resolution. However, in developing countries, often the skill of available forecasts is insufficient to create a more effective triggering mechanism as part of a flood EWS.

This research presents an assessment of two methods to improve an existing flood EWS using a case study of the most flood-prone area of Malawi, i.e. the Lower Shire Valley. First, the forecast skill and trigger levels of the medium-term Global Flood Awareness System (GloFAS) model are determined for four gauge locations to assess how they can improve the national EWS. Secondly, an assessment is done on how the process of integrating flood forecasts based on local knowledge with official forecasts, can help to improve the EWS. This is done by semi-structured interviews at the national level and focus group discussions at the community level. The study shows that GloFAS does not predict absolute discharge values precisely, but can be used to predict floods if the correct trigger levels are set per location. The integration of multiple forecast sources is found to be useful at both national and community levels. An integration process is proposed where village stakeholders should take the leading role by using existing disaster management and civil protection coordination mechanisms. Overall, both methods can contribute to improving the flood EWS and decreasing the flood risk in the Lower Shire Valley in Malawi.


The number as one of the constants of the global culture is a logical and cultural phenomenon, and the study of such phenomenon in each national language enables to define its conceptual features and particulars of interaction of the language and the culture. Folklore works which contain names of numbers in their composition can show the features of the language pictures of the world of different nations clearly and vividly, in which the national features are combined in a peculiar way. It is known that numbers used in folk tales show different linguistic traditions. Linguistic-cultural analysis of numbers involves the study of numerical concepts, taking into account their linguistic, etymological and national cultural characteristics. This article aims to study the ethno-cultural symbols of the numbers in Tatar and Russian languages, found in the folk tales of these peoples. The relevance of this paper is conditioned with the fact that results of researches of the numerological code of the Tatar and Russian languages help to identify the common and the unique in the linguistic world image of ethnically different peoples that have contacted for a long time. The purpose of this paper is to describe lexical semantical properties of the number symbolism in the Tatar and Russian languages in the linguistic cultural aspect. Comparison of the philosophic understanding of the world image from the perspective of numbers, analysis of their symbolism with different peoples enables to analyses the specificity of their world outlook and to better understand common languages specific for the linguistic semantics, to establish the link between the language and the culture, to demonstrate the real significance of each of the components of the semantic structure of the world in the diachronous and synchronous perspectives.


This paper describes how the National Institute for Land and Infrastructure Management (NILIM), Ministry of Land, Infrastructure, and Transport (MLIT) is researching and developing the Intelligent Transportation System (ITS) for Pedestrians. The system will provide information on barrier-free facilities and routes to support mobility for the visually impaired and wheelchair users. The paper demonstrated that an information service system using RF-ID (radio frequency identification) tags to identify the exact position of the pedestrian is capable of providing reliable information to the visually impaired and wheelchair users. The needs that precede practical application are: to verify the maintenance costs for the RF-ID tags and digital maps; demonstrate information service validity for the users, particularly the visually impaired; and to evaluate the cost effectiveness of the system. To these ends, a long term monitor experiment will be conducted on actual roads.


ABSTRACT The commonly used acrylic resins for fabricating denture base suffer from poor mechanical properties. This study aimed to assess the effect of incorporating Titanium Dioxide (TiO2) nanoparticles (NPs) as a reinforcement agent on the compressive strength of different acrylic denture base materials. Thirty-two cylindrical specimens (22 mm in height and 12 mm in diameter) were prepared from PMMA resins with and without TiO2 NPs. They were allocated into two main groups according to the materials used such as cold cure and heat cure denture base resins and then divided into two subgroups each containing eight specimens: control (without nanoparticles) and experimental (with 2 wt.% TiO2 NPs). TiO2 NPs were synthesised via a chemical processing route. Particle morphology and size distribution were assessed using SEM and AFM while XRD technique was employed to determine the crystalline structure of the NPs. Compression test was performed on the specimens using a universal Instron testing machine to compare the compressive strength. Size of crystalline TiO2 NPs varied between 40 and 80 nm. The mean compressive strength for the cold cure acrylic resin (control group) and its nanocomposite (experimental group) were found to be 15.37 MPa and 17.42 MPa while for the heat cure acrylic resin and its nanocomposite were 23.04 MPa and 24.30 MPa. A statistically significant difference was recorded between the compressive strengths of cold cure acrylic resin and its nanocomposite. However, the difference was non-significant in the case of heat cure acrylic resin. The compressive strengths of both cold cure and heat cure acrylic resins increased after the incorporation TiO2 NPs.


As a risk practitioner I'm exposed to workplace common sense deficiencies all the time. We are all too familiar with the countless emails and social media pictures we receive of workplace safety fails completely lacking common sense, which would suggest that common sense in the workplace, isn't common practice!


An ultrafine-grained Al-5083 alloy reinforced with 5 vol.% nano-sized β-SiC particles was fabricated with a powder cryomilling and consolidation technique. Tensile tests were conducted at temperatures from 298 to 773 K for this composite. The mechanisms for deformation and fracture of this nanostructured composite at various temperatures are discussed.


A systematic study is made on the strong prophase signal for serious cold damage with a view to form the forecast conceptual model, by using various information such as 500hPa altitude field, the North Pacific marine temperature field, firn on the Qinghai-Tibet Plateau, and physical quantity reflecting atmospheric activity. This provides information in various aspects for forecast of serious cold damage in Guangxi.


Long integration time of GEOSAR makes it difficult to deal with the maneuvering target due to the complex relative motion between radar and target. This paper addresses the motion parameters estimation problem of high speed maneuvering target in GEOSAR where translation motion and rotating motion are considered. A method based on Keystone transform, Fractional Fourier Transform (FrFT) are introduced to estimate and compensate the translational motion and extract micro motion feature. The effectiveness of the method is validated by simulation results.


A PECULIAR facies suggesting kinship has been found in some nonfamilial cases of supravalvular aortic stenosis in childhood.1 2 3 4 5 In addition, it has been recognized that infants with idiopathic hypercalcemia have a rather characteristic "elfin" facial appearance. Recently described are a group of older children with "aortic stenosis" and an "elfin" fades. An illness during infancy in each patient was suggestive of idiopathic hypercalcemia.2 Their facies appeared identical to those of patients with supravalvular aortic stenosis described by others.1 , 3 , 4 It seems unlikely that this remarkable similarity is coincidental. Although an association between idiopathic hypercalcemia and supravalvular aortic stenosis has been alluded . . .


This paper discusses the design, implementation, and potential use of an ontology‐based mobile pediatric consultation and monitoring system, which is a smart healthcare expert system for pediatric patients. The proposed system provides remote consultation and monitoring of pediatric patients during their illness at places distant from medical service areas. The system not only shares instant medical data with a pediatrician but also examines the data as a smart medical assistant to detect any emergency situation. In addition, it uses an inference engine to infer instant suggestions for performing certain initial medical treatment steps when necessary. The applied methodologies and main technical contributions have three aspects: (a) pediatric consultation and monitoring ontology, (b) semantic Web rule knowledge base, and (c) inference engine. Two case studies with real pediatric patients are provided and discussed. The reported results of the applied case studies are promising, and they demonstrate the applicability, effectiveness, and efficiency of the proposed approach.


Risk and protective factors associated with suicidal ideation among 1,377 Asian American college students across 66 U.S. campuses were examined. The results indicated a variety of factors were associated with morbid thoughts: medication for mental health concerns, gender, GPA, undergraduate status, religious affiliation, living with a family member, living with a partner, and active participation in student organizations. Furthermore, some of these factors were related to serious consideration of suicide: medication for mental health concerns, undergraduate status, living with family, and active participation in student organizations. Among Asian Americans who seriously considered suicide in the past 12 months, recent family, academic, and financial problems were the top three most frequent significant events occurring before the development of suicidal ideation.


Greenhouse experiments determined differences in imazaquin bioavailability over time under various soil moisture regimes. All soils were initially fortified with 63 ppb (w/w) of commercially formulated imazaquin. Treatments consisted of maintaining at field capacity for 15 wk (FC), maintaining air-dry for 15 wk (AD), soil that was maintained air-dry for 2 wk and then wet to field capacity at 2 wk intervals (2WAD), and soil that was wet to field capacity at the initiation of the experiment and at 2 wk intervals (2WFC). Little dissipation of imazaquin occurred in the AD soil over the 100 d of this study. Rapid dissipation over the first 35 d occurred for the other three treatments. Imazaquin half-life ranged from 17 to 18 d for the FC, 2WAD, and 2WFC soils. Imazaquin concentration increased or only slightly decreased in samples taken after the second watering in both the 2WAD and the 2WFC soils. Due to differences in adsorption/desorption of imazaquin with changing soil moisture levels, bioassays may not determine the dissipation of the actual concentration of imazaquin contained in soil.


The results of the evaluation of zinc maleate and zinc anthranilate as thermal stabilizers for poly(vinyl chloride) (PVC) are reported in this article. Calcium stearate, diphenyl isodecyl phosphite, and epoxidized soya oil were used as costabilizers. Both zinc compounds showed good stabilizing performance in static and dynamic tests, particularly at low concentrations. The best results were obtained with zinc anthranilate. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 77: 2603–2605, 2000


Regulation of university research funds based on process control emphasizes concepts,objects,and methods.These three factors have a significant impact on the regulatory process.Accordingly,this paper established a process control system model for the regulation of university research funds.This model includes the dimensional coordinates consisted of regulatory process,the key nodes,and factors.Based on process control theory,university research funds supervision should be done by correcting regulatory philosophy,specifying regulatory targets,and using integrated regulatory approach.


Objective To evaluate management options for cochlear implantation in patients with chronic suppurative otitis media. Study Design Retrospective case review. Setting Tertiary referral center with a large cochlear implant program. Patients Ten patients with chronic suppurative otitis media who received cochlear implants were identified. Case history, etiology of hearing loss, and management of the ear with the implant were evaluated. Interventions Cochlear implantation and subsequent rehabilitation. Main Outcome Measures Early and late complications were evaluated. Results No early or late complications were identified in this group of patients after an average follow-up period of about 4 years. Conclusion Cochlear implantation can be safely achieved in patients with chronic suppurative otitis media. There are several options for the management of these patients, and the approach chosen should be individualized on the basis of clinical findings.


This study concentrates on utilization of alternative intensity measures (IMs) in the formation of ground motion record (GM) sets that could be used for nonlinear time history based seismic demand analyses. To recommend suitable IMs that will be taken as basis in ground motion database formation, correlation of several IMs with top drift demands of single-degree-of-freedom (SDOF) systems has been evaluated as the first step for different levels of strength reduction factor (R) and ductility () utilizing records from PEER's NGA ground motion database. From the results of SDOF-based study, alternative ground motion record sets have been formed considering candidate IMs and following a stratified random sampling approach. As the next step, seven reinforced concrete frames having different structural properties were dynamically analyzed utilizing these record sets and major engineering demand parameters (EDPs) were extracted from the nonlinear time history analysis results to investigate the correlation performance of the selected IMs designating their suitability in the use of ground motion selection.


Abstract. The aim of the presented paper will be the calculation of the estimated life expectancy at birth for males and females in the Czech Republic using selected levelling functions (Gompertz–Makeham, Kanistö and Thatcher) and using ARIMA model and Random Walk with Drift, constructed for the time series modelling. The levelling functions for modelling mortality rate are nonlinear, thus difficult to solve, ARIMA models are in turn based on entirely different principles (stochastic process and backward looking expectations). Subsequently it will be pointed to differences that arise when using both methods and the differences that occur when we compare the estimates that are published by the Czech Statistical Office. Given that the estimates of life expectancy at birth using different approaches are similar, then based on ARIMA model and Random Walk with Drift there will be extrapolated to the near future (2012–2030). Presented alternative estimates will be correlated with predictions which are calculated by the Czech Statistical Office and it will be easier to obtain them, because they are based purely on a statistical approach, which does not require the additional demographic information, which are expensive to obtain.


This paper describes a way of implementing DPC in a Gaussian MIMO broadcast channel. The outer encoder is based on a vector TCQ designed to possess certain "good properties". Simpler schemes such as the Tomlinson Harashima or scalar Costa's scheme are also considered by a way of comparison. The inner encoder is implemented through a vector version of the ZF-DPC and the MMSE-DPC. The BER performance of the DPC schemes is evaluated and compared to that of conventional interference cancellers (pre-ZF, pre-MMSE). From simulation results the choices of the inner encoder, the outer encoder (THS/SCS/TCQ) and the interference cancellation technique (conventional or DPC) are discussed


The condition is reported to be associated with chronic irritation of horns at the base (Sastry, 2001). The most commonly observed clinical signs are frequent head shaking, tilting at the affected side, bending of affected horn and nasal discharge in advance cases (Joshi et al., 2009). The bullocks appear to be highly susceptible as compared to bulls and cows. Carcinoma of horn core in cattle is primarily squamous cell neoplasm (Patra, 1963).


Hormones and neurohormones act on the nervous system to produce important changes in behavior. This article uses studies of amine actions in the lobster nervous system and their possible relationship to aggressive behavior in lobsters to explore how such changes might come about.


The nature of large-scale evolutionary processes that shape genomes over time fundamentally differs from the forces governing local evolution within individual genes. Large-scale events such as horizontal transfer, genome rearrangements, gene duplication, and gene loss obscure the notion of orthology and have demanded new models of evolution. Multiple genome alignment tools must cope with such large-scale changes in addition to local changes such as nucleotide substitution and indels. Using simulated genomes containing both large and small-scale evolutionary changes, we present an alignment quality comparison of Mauve, a multiple genome aligner that considers large-scale evolutionary events, to alignments generated by other state-of-the-art genome alignment systems. Our results indicate that in the presence of large-scale rearrangement events, Mauve has superior accuracy. Mauve is available from http: //gel. ahabs.wise.edu/mauve.


Investigations on uranium extraction from a representative mineralized granite sample (Gattar granite GII) by solvent-in-pulp (SIP) technique were carried out in the present study. For this purpose, the solvent (tri-butyl amine) (TBA) was mixed with the leaching slurry without prior filtration. The influence of various factors affecting the SIP process, such as contact time, solvent concentration, dilution factor, type of surfactant, surfactant/solid ratio were studied. About 91% uranium extraction efficiency was attained by the application of the chosen extraction SIP conditions. Also, about 96% of the loaded uranium could be stripped by using sulfuric acid as an effective stripping agent.


The study of processes based on cavitation use required a clear definition of phenomena arising in liquid at high-frequency oscillation impact upon it. For the in-depth study of the phenomena under investigation in the given work there was used a high-speed video filming. As the analysis of high-speed filming has shown after closing a bubble is divided into many pieces which, in their turn, pulse in-phase. At the same time there is observed a formation of complex bubble formations which are offered to be called clusters (Fig. 3). Bubbles formed under the influence of variable acoustic pressure and located at a small distance from each other combine. Two processes take place simultaneously – bubbles combining (coalescence) and the integration of small bubbles in larger ones under the influence of cohesion forces with the formation of general structures (coagulation). The coalescence is followed with the transition of a system in a state with lower free energy.


Thermodynamics is one of the most basic branches in physics. However, its mathematical background is still obscure. The crucial point lies in our lack of mathematical setting which represents thermodynamic state space. In some other branch of physics, the state space of a physical system may be clearly defined. In classical mechanics it is described by the cotangent bundle over a configuration space, and in quantum mechanics by a Hilbert space. If we consider only equilibrium states of a thermodynamic system, we can think of a suitable open subset of a Euclidean space as a state space. But it is not so easy to set up a state space which includes non-equilibrium states. Another crucial problem lies in the notion of entropy. Entropy plays a role of great importance in thermodynamics. However, it is clearly defined only for equilibrium states. Many attempts have been made to extend the notion to non-equilibrium states. The basic idea can be roughly described as follows. Divide a system Σ into small subsystems Σi so that each Σi is in an equilibrium state, and then define the entropy of Σ as the total sum of the classical entropy of Σi . Prigogine fully carried out this idea and defined entropy by using integration (see [5], [6]). But the definition is only justified by the so-called local equilibrium assumption, which is not necessarily accepted by physicists. In 1931, Onsager developed a theory of linear non-equilibrium thermodynamics (see [3], [4]). We shall sketch his theory for an isolated systemΣ . Suppose that the entropy S of Σ is defined on a sufficiently small neighborhood M of an equilibrium state and that S is a differentiable function of extensive variables x1, . . . , xn onM . Then every thermodynamic process x(t) = (xi(t)) of the isolated system Σ satisfies the following ordinary differential equations: dxi


Checkpoint inhibitors are novel immune-stimulating antibodies that have revolutionized the management and prognosis of several malignancies. The primary targets are cytotoxic T-lymphocyte–associated antigen-4 (anti-CTLA-4; e.g. pembrolizumab) and programmed cell death-1 receptor (anti-PD-1; e.g. ipilimumab and nivolumab). In spite of the significant advantages, many immune-related adverse effects have been identified. One of which is checkpoint inhibitor-induced colitis (CIC). Although there is awareness of the histopathologic features of anti- CTLA-4 induced colitis, there is much to be discovered about the pathologic features of anti-PD-1 colitis.

 We herein report three cases of CIC. There were two women and 1 male (age range, 50 to 73-years-old, mean 64-years-old) who presented with diarrhea and/or hematochezia after multiple cycles of pembrolizumab or ipilimumab/ nivolumab combination therapy. Endoscopic examination was abnormal in all of these cases.

 The histologic features were similar in two cases, with moderate active chronic colitis and one case with focal active colitis. Two of the three patient were given steroids in addition to their regular medications with symptom improvement. One patient was removed off all medications and enrolled into hospice due to disease progression. CIC has been an increasingly recognized immune-related adverse effect that has a wide spectrum of clinical presentations ranging from mild diarrhea and abdominal pain to severe colitis and intestinal perforation. However, it is thought to be underestimated. Histologically, CIC can mimic inflammatory bowel disease, microscopic colitis and active colitis. Our cases showed histopathologic features mimicking those of ulcerative colitis.

 Awareness of CIC is crucial for the multidisciplinary management essential for these patients. The histopathologic pattern coupled with the clinical history can allow pathologists to confirm the diagnosis of CIC and facilitate timely diagnosis and treatment.


Understanding how humans explore the world in search of novelties is key to foster innovation. Previous studies analyzed novelties in various exploration processes, defining them as the first appearance of an element. However, innovation can also be generated by novel association of what is already known. We hence define higher-order novelties as the first appearances of combinations of two or more elements, and we introduce higher-order Heaps' exponents as a way to characterize their pace of discovery. Through extensive analysis of real-world data, we find that processes with the same pace of discovery, as measured by the standard Heaps' exponent, can instead differ at higher orders. We then propose to model the dynamics of an exploration process as a random walk on an evolving network of the possible connections between elements. The model reproduces the empirical properties of higher-order novelties, revealing how the space of possibilities expands over time along with the exploration process.


Gluten related‐disorders have a prevalence of 1–5 % worldwide triggered by the ingestion of gluten proteins in wheat, rye, barley, and some oats. In wheat gluten, the most studied protein is gliadin, whose immunodominant 33‐mer amino acid fragment remains after digestive proteolysis and accumulates in the gut mucosa. Here, we report the formation of 33‐mer thin‐plate superstructures using intrinsic tyrosine (Tyr) steady‐state fluorescence anisotropy and cryo‐TEM in combination with water tension measurements. Furthermore, we showed that fluorescence decay measurements of 33‐mer intrinsic fluorophore Tyr provided information on the early stages of the formation of the thin‐plate structures. Finally, conformational analysis of Tyr residues using minimalist models by molecular dynamic simulations (MD) demonstrated that changes in Tyr rotamer states depend on the oligomerization stage. Our findings further advance the understanding of the formation of the 33‐mer gliadin peptide superstructures and their relation to health and disease.


An analytical framework close to the canonical model on platform competition introduced by Rochet and Tirole (2004) is used to investigate the two-sidedness of the market for custodian services. The canonical model has to be changed to include the effects of bundling. It becomes clear that horizontal consolidation of the European post-trading institutions is welfare increasing.


This study was designed to determine the effectiveness of extensive pre-guidance, periodic checking, and detailed correction and comment on specific preliminary steps in the development of the documented research paper, written by freshman English students, according to their grade achievement. Also included was a cross-check analysis of written essays, prepared and impromptu. The study involved the research papers of forty-eight students enrolled in two classes. One group received detailed guidance, the other did not. An evaluation chart, developed by the instructor and another rater, was used on all papers; a systematic sampling of 19 percent of these was graded by the second rater. The inter-rater reliability coefficient (Pearson r) was established as .96.The hypothesis-there will be no significant difference in the grade achievement of separate sections of second semester freshman English students on the research paper according to different instructional procedures-was not rejected. The conclusion wa...


The present work has as the main theme the uses and meanings of the practices of reading and writing in a field school in the district of Serra Talhada (PE), and aligns with the literacy conception sanctioned for the New Literacy Studies theorists (NEL), that understand literacy practices are permeated of beliefs, values, attitudes and individual and social ideologies beyond being signed by time and space. To develop this work, we have chosen, as a focus of attention, a school in Serra Talhada district (PE), and as a locus of observation, classroom environments of a fifth-grade class, as well as the external spaces to this room. Our theoretical framework supports the central discussions of our thesis: reading and writing practices, the field education and the study of everyday life. For believing that the daily practices are "built" from the union of many factors and for understanding that different environments reflect different realities, we established as a general objective of the research to know and to analyze the everyday life of this school with regard to events and literacy practices experienced by the school community. So, we intend to identify and analyze the actions and uses that involve writing and reading, starting from the agreement that different individuals develop different practices. We conducted a qualitative study, with ethnographic principles, so that we can, in fact, analyze the process of construction of the reading and writing practices creations, in order to highlight their particularities. We chose research instruments to describe and understand the micro contexts where the focused literacy practices were developed. So, we intended to identify and analyze the actions and uses that involve writing and reading, starting from the agreement that different individuals develop different practices. We conducted a qualitative study, with ethnographic principles, so that we could, in fact, analyze the process of construction of the reading and writing practices creations, in order to highlight their particularities. We choose research instruments to describe and understand the micro contexts where the focused literacy practices were developed. To generate the data to the continuation of the research, we used as instruments: observation - while main research technique; semi-structured interviews with the team manager of the institution, students' parents and a school teacher, and a questionnaire applied to parents of pupils and students of the school. Our results point out that in the everyday life of the focused school there are several moments in which it is possible to understand transformed attitudes and discourses, or better, "built" according to the present context and with the demands of the situation. This movement allowed us to look at the singularities, since daily practices reveal ways to make constructions and usages and give us clues about the uses and meanings of the language written in that context. We concluded that the writing is (re) signified to and (re) adapted to the different situations of everyday life, which presents, sometimes approaches to the practical aspects of the ideological literacy and, sometimes, to the aspects of the autonomous model of literacy. We believe that this research will help to consolidate the goals proposed for the education, making the school a place where cultural diversity promotes educational quality, effective participation of the community and expansion of literacy experiences in the search for an effective exercise of citizenship.


This paper reports on the findings and implications of a study of the performance of small-scale physical lighting models. It seeks to clarify the primary causes of divergence between model and real building performance and to discuss the main factors involved in achieving accurate physical representations of buildings. A brief account of a case study is given in which an existing museum building was modelled. The methodology adopted is described and an analysis of the model's divergent performance from that of the building is made. This is followed by an examination of the core issues in scale modelling for accurate daylight prediction. The latter focuses on sources of error in the model's representation of dimensions and photometric properties. Drawing on examples from the case study it is suggested that the size of such errors may account for the apparently persistent overestimation of illuminance levels by lighting models. Proposals are suggested for dealing with error ranges in small-scale model performance.


In this article, we investigate the role of the self-interaction error in the simulation of collisions using time-dependent density functional theory (TDDFT) and Ehrenfest dynamics. We compare many different approximations of the exchange and correlation potential, using as a test system the collision of $\mathrm{H^+ + CH_4}$ at $30~\mathrm{eV}$. We find that semi-local approximations, like PBE, and even hybrid functionals, like B3LYP, produce qualitatively incorrect predictions for the scattering of the proton. This discrepancy appears because the self-interaction error allows the electrons to jump too easily to the proton, leading to radically different forces with respect to the non-self-interacting case. From our results, we conclude that using a functional that is self-interaction free is essential to properly describe charge-transfer collisions between ions and molecules in TDDFT.


We study the formulation of statistical mechanics on noncommutative classical phase space, and construct the corresponding canonical ensemble theory. For illustration, some basic and important examples are considered in the framework of noncommutative statistical mechanics: such as the ideal gas, the extreme relativistic gas, and the 3-dimensional harmonic oscillator.


Reverberation Chambers are often made of commercialised shielding rooms with dimensions in the meter range. On one hand this is very expensive; on the other hand the maximum amplitude of the E-field decreases with volume for a given input power. In the lower GHz-range small chambers with volumes below 1 m3 provide much higher field strengths at low input power. If small devices need to be tested at high field strength in the GHz-range, the use of commonly known mode tuners is not efficient due to loss of the usable volume. Therefore in order to replace the time and volume consuming tuner process, the paper shows the impact of frequency modulated signals on the field conditions for susceptibility testing in a small reverberation chamber with a volume of 0,38 m3.)


Argostemma tortilobum, a new species endemic to Vietnam, is described and illustrated. The species is morphologically most similar to A. sarmentosum, but differs in having erect stem without runners, densely pilose peduncle and twisted corolla lobes with ciliate margins.


Electrical stimulation of the visual cortex causes subjects to see spots of light (phosphenes) in their visual fields. The authors have developed arrays of penetrating electrodes which can form the basis of a visual prosthesis centred around electrical stimulation of the visual cortex. These arrays have been constructed of inert materials, and have been implanted into cats to test array insertability and biocompatibility. Tests to determine electrode wire insertion force have also been performed. Preliminary acute histological results have shown little cortical damage due to the implants.<<ETX>>


Audit report delay in municipal governments is a condition that has worsened, on average, over the past few decades. The purpose of this study is to identify variables that influence audit timeliness in governments. The data analyzed in this study are from a state that has historically had longer delays in reporting (currently an average of 420 days from fiscal year-end until the date the audit report is submitted). This research utilizes ordinary-least-squares regression to estimate the effect of several variables on the time it takes to file audit reports with the state auditor's office. The research also utilizes logistic regression to estimate the effects of those variables on the incidence of filing reports after state-mandated deadlines. Variables found to be associated with both longer audit report delay and late audits include the number of audit findings and the receipt of an adverse or qualified audit opinion. Travel distance between the auditor's office and the client's office was also found to play a role in timeliness. A greater amount of long-term debt carried by the governmental entity was not found to be associated with shorter audit delays but was found to be somewhat associated with audits filed on time.


This article describes a simple method of evaluating the importance of specific energy information system (EIS) requirements. This method helps organizations that have identified a need to develop an EIS but can't find the time to define the complex requirements. It is a method intended to speed up the process without sacrificing the quality of the process. Energy management teams typically know a lot about the need for each requirement, but very little about the cost or effort to produce it. On the other hand, information technology (IT) development teams know more about costs and effort than the relevant importance of each of the requirements. Therefore, the conditions are set for confusion, and the likelihood of disagreements is high. Our goal in using this method of requirements definition is to prevent cost evaluation from tainting the need evaluation of any one of the proposed features of the EIS. This method breaks the requirements definition down into manageable tasks, evaluates the best balance between need and cost for each of the requirement tasks, and then produces a priority of work document to guide the development team.


With video obsevering,actual combat simulation and static state intercept methods,this paper from angle of statics studied the phenomenon of attacking player dribble storm attack misplay. Findings: three reasons misplay in attacking players. The first reason is dribbled overexert,the second reason is that attacking players'attention put at counterwork with defense player,the third reason is existing problem in holding the part of the basketball. On the basis of these the author puts forward some suggestions.


Parasympathetic stimulation decreases heart rate and force of contraction and involves acetylcholine binding to M2, activation of the G protein‐activated inward rectifier K+ channel (GIRK1)2/(GIRK4)2. Although GIRK4 is required for the generation of IkAch, no data on the regulation of its expression are available. In a model for lipid lowering, culture of atrial myocytes in lipoprotein depleted serum (LPDS) increased GIRK4 promoter activity (GIRK4‐Luc) and protein compared to cells grown in FBS. LPDS stimulated phosphorylation of Akt while LPDS‐stimulated GIRK4 promoter was inhibited by the p‐Akt inhibitor, LY294002. LPDS increased SREBP1 and SREBP1 increased GIRK4 promoter in myocytes. Insulin treatment of myocytes increased SREBP‐1, GIRK4 promoter, GIRK4 protein and p‐Akt. LY inhibited insulin‐stimulated GIRK4 expression. Diabetic autonomic neuropathy is associated with parasympathetic dysfunction. In the type 1 diabetic Akita mice, which demonstrate parasympathetic dysfunction, expression of GIRK4 and SREBP1 in the atrium was decreased compared to WT. Insulin treatment of Akita increased level of SREBP1 and GIRK4 to that in WT and reversed parasympathetic dysfunction. Given that insulin has been shown to regulate SREBP, these data suggest that hypoinsulinemia in type 1 diabetes might result in parasympathetic dysfunction due to decreased SREBP and GIRK4 and Akt might play a role in this pathway.


(1949). Safety Measures in Skiing. Journal of the American Association for Health, Physical Education, and Recreation: Vol. 20, No. 2, pp. 89-124.


Classification of biophysical properties within each micro-catchment. Same as 'Class2' only using mean slope attribute rather than the majority slope attribute. Derived using the COMBINE command in ArcGrid with 'slopezone', 'aspectzone2' and 'soilzones', producing 60 biophysically unique micro-catchments.


This study analyzed the caloric share of ultra-processed foods in preschoolers' lunchboxes and associated parental attitudes. The snacks were registered and classified according to the NOVA classification: In Natura or Minimally Processed Foods; Processed Foods; Ultra-processed Foods and Culinary Ingredients. A questionnaire was applied to the parents to identify parental attitudes. Pearson's Chi-Square, Student's t-tests, and Beta regression models were used. The caloric share of ultra-processed Food in lunchboxes was 55%, being 7% for In Natura or minimally processed foods. There was a significant association between the caloric share of ultra-processed food and parental attitudes: only sending snacks that kids like (p=0,005), choosing foods with the child's favorite TV characters(p=0,03), convenience(p=0,01), being able to buy all snacks at the supermarket(p=0,002), not reading the food label(p=0,025), not having information to prepare a healthy lunchbox(p=0,016), and the mother not being the person who prepares the lunchbox(p=0,002). Parental attitudes are strongly associated with the children's eating habits, which is why it is important strengthening public policies that regulate the provision of ultra-processed foods.


The spacecraft in space is exposed to charged particle bombardment leading to significant charging and distorting the wake structure. The complexity of interaction between spacecraft and particle is difficult to assess, thus needs to be resolved numerically using appropriate method. Electro Magnetic Spacecraft Environment Simulator (EMSES) was developed based on Particle-in-Cell (PIC) which treated not only electrostatic phenomena but also selfconsistent analysis of electromagnetic effects on the spacecraft surfaces. We employed EMSES to simulate the charging of ERS-1 spacecraft and its influence on the vicinity of the spacecraft in low Earth orbit (LEO) environment. We focused on the floating potential of the spacecraft and the wake structure in the downstream region of the spacecraft. We also present the contribution of electric field to drive the ion trajectory passing through the sheath edge of the spacecraft.


Inflammation is a protective action that role on defending mechanism to defeat agent causing cell injury. Glucoside of skunkvine (Paederia scandens) has anti-inflammation effect. The aim of this study was to know the anti anti-inflammatory effect of skunkvine (Paederia scandens) extract on artificial edema in Wistar rat. Thirty-five Wistar rats were divided into 7 groups, each group consisted 5 rats. In the control and treatment groups, aquadest (negative control), fenilbutazon (positive control), skunkvine extracts in dose 10mg/kgBW, 20mg/kgBW 30mg/kgBW, 40mg/kgBW, and 50mg/kgBW were administered per orally. In order to induce the edema, one hour after administration, in each group, right hind paw of the rats was injected subcutaneously with by 1% carrageenin. The volume measurement performed with one hour interval for 5 hours assessing with pletysmometer. The data were analyzed by ANOVA. The result of this study showed there was significant difference on group with skunkvine extract 20mg/kg BW to negative control and positive control. In conclusion, that the skunkvine extract 20 mg/kgBW has potency as anti-inflammation substance.


Almost 20% of the patients with multiple myeloma (MM) associate renal involvement, and 5% need long-term haemodialysis treatment. Both plasmapheresis and high cut-off haemodialysis (HCO-HD) have been used to remove light chains from the blood and minimize the renal damage. In the largest study, plasmapheresis has been shown to be ineffective in the renal recovery. Furthermore, the most important trial, EuLITE II, concluded that HCO-HD did not improve renal recovery and independence from haemodialysis. The hypothesis of this work is that patients with an acute renal failure related to multiple myeloma undergoing early HCO-HD treatment, before being haemodialysis-dependent, may achieve better renal function in short and, perhaps, in long term.

 We have studied five patients with multiple myeloma and acute renal failure who received treatment with HCO-HD in order to remove serum kappa or lambda light chains. The procedure was realized with Filtryzer BK2.1F dialyzer (Palex Medical) with an area of 2.1 m2 at a blood flow of 250 ml/min and a dialysate flow of 500 ml/min, usually changing the dialyzer in the middle of the session. The sessions lasted between 6 and 8 hours, initially on successive days, and alternate days afterwards.

 Between July 2016 and November 2019, five patients with a mean age of 67.8 years (2 women and 3 men) received HCO-HD. Three of them had MM with lambda light chains, and two of them had MM with kappa light chains. The average bone marrow plasmocytosis was 38.6 % (minimum 10% and maximum 90%). Two patients required treatment with haemodialysis for glomerular filtrate (FG) estimated by MDRD-4 formula of 4 and 5 ml/min, respectively. The other three had a GF (MDRD-4) between 19 and 30 ml/min. Initial hematological treatment included bortezomib, dexamethasone, and thalidomide. One patient was switched to carfilzomib. Only two patients underwent renal biopsy, both showing myeloma kidney with intratubular light chain casts. An average of 9.8 sessions has been administered (minimum 5, maximum 19). At the end of the treatment, serum kappa light chains decreased from a mean of 29461 mg/L to 1516.5 mg/L, and serum lambda chains decreased from a mean of 7245 mg/L to 1030.66 mg/L. At the beginning of the treatment the mean GF (MDRD-4) was 17.4 ml/min, 29.6 ml/min at the end of it, and 42.33 ml/min six months later (table 1). Only one patient became dependent of haemodialysis. This patient developed renal failure in context of a second relapse of a very aggressive myeloma. Another patient who presented 47900 mg/L of serum kappa light chains at diagnosis, 90% bone marrow plasmocytosis, and a GF (MDRD-4) of 30 ml/min when started HCO-HD, in the present and few days after 19 sessions has a GF (MDRD) of 43 ml/min.

 An early treatment with HCO-HD, before the patients need renal replacement therapy, may lead to a better renal outcome and independence from haemodialysis at least in the medium term. Largest studies are necessary to confirm this hypothesis.


A 426 cm core from Lake Barkol,eastern Tian Shan,provides the evidence of Holocene climate in Westerly dominated Asia.Here,we present a grain-size component series decomposed by empirical orthogonal function and the chronology is based on radio carbon dating.The results show that the EOF1 component has a high correlation coefficient(0.64) with the volume percentage of the component less than 2 μm,furthermore it is similar to the evolution pattern of oxygen isotope from carbonate which is a proxy indicating the regional effective moisture,so the EOF1 component is an indicator of the effective moisture in the region.Modern dust grain-size analysis from Barkol shows a peak percentage around 61.2 μm.Coincidently,the EOF2 component has a high positive correlation coefficient with the grain-size ranging from 45 to 138 μm,which suggests that the EOF2 indicates the regional dust activity.EOF results suggested that the effective moisture was low and the dust activity was strong in mid-Holocene,which was consistent with the mid-Holocene arid interval occurred in the northern Mongolia Plateau.The enhanced Siberia high intensified the Westerly circulation and winter monsoon,and which could be the main reason for the arid and dusty mid-Holocene climate in the research region.


We demonstrate a fabrication of ferroelectric optical nanocomposite thick films by aerosol deposition method (ADM) and report their highly enhanced optical and electrical characteristics. Nanocomposite gold / PZT 3-¿m-thick films acquired the enhanced surface plasmon resonance at a wavelength of 640 nm as well as the enhanced electrical properties. The strength and the position of surface plasmon resonance at the nanocomposite films deposited by ADM could be controlled by adjusting the concentration and the shape of nanogold in the host matrix.


An equilibrium point learning problem in discrete-time dynamic neural networks is studied in this paper using stable dynamic propagation with constrained learning rate algorithm. The new learning scheme provides an adaptive updating process of the synaptic weights of the network, so that the target pattern is stored at a stable equilibrium point. The applicability of the approach presented is illustrated through a binary pattern storage example.


Disclosed is the preparation of quinophthalone derivatives of the general formula (I), in which the grouping A makes up unsubstituted or substituted heterocyclic aromatic rings and the grouping B makes up an unsubstituted or substituted aromatic ring, by reacting a methyl-substituted heterocyclic compound of the general formula (II), with an anhydride of an aromatic dicarboxylic acid of the general formula (III) or with the corresponding free dicarboxylic acid (IIIa) in the presence of an acid plus an organic solvent, using as the organic solvent an alkyl ester of benzoic acid.


Pseudo‐Bartter's (PB) syndrome characterized by hypokalemic metabolic alkalosis and persistent failure to thrive constitutes a rare typical presentation of cystic fibrosis (CF) with prevalence of 16.8%. We present a case of CF presenting with failure to thrive, dehydration, PB syndrome associated with chest infection and primo‐colonization with Pseudomonas aeruginosa. Sweat chloride test was 102 mmol/L. DNA analysis identified 2 mutations 3849 + 1G>A (intron 19) and 4382delA (exon 24) present in heterozygous status. To the best of our knowledge, our case is the first reported case in the literature of CF manifested by PB syndrome associated with chest infection and primo‐colonization with Pseudomonas aeruginosa.


At present, for the vast majority of enterprises, profit is the inexhaustible driving force for their development. For enterprise managers, the level of profit is directly related to their enterprise decisions. Starting from the current management of hotel enterprises, this paper studies the management methods of hotel bedroom capacity, and puts forward an effective and scientific management mechanism of hotel bedroom capacity, in order to give some inspiration to hotel enterprise managers.


The problem of a normal impact and penetration of rigid spatial bodies of a finite mass into a half-space occupied by an elastoplastic soil medium. The penetrated medium is modeled by linearly compressible elastoplastic Grigoryan medium, with the yield strength linearly depending on pressure. The problem is analyzed in a 3D formulation, using software package LS-DYNA. The elastoplastic penetrated medium is analyzed on a fixed Eulerian grid with empty meshes, where the material flows to in the process of deformation. Spatial strikers are modeled by a rigid non-deformable body in a Lagrangian coordinate system. The effect of surface friction during the penetration of strikers of various forms (a round cone, a four-ray star and a pyramidal body) into elastoplastic Grigoryan soil medium is studied. The cross-section of the star-shaped body is generated by two rhombs with the ration of diagonals of 1:2; the base of the pyramid is a rhomb with the ratio of diagonals of 1:3. The analyzed bodies have equal areas of the bases and equal inclinations of the side surface (the angle between the direction of the motion velocity vector of the body and a normal to the side surface). A circular cone with the same base area is considered for comparison.The considered strikers moved with constant velocities and mechanically, in the velocity range of 150 to 600 m/s, corresponding to subsonic and supersonic velocities. The surface friction coefficient is close to the value of the friction coefficient in sandy soils of natural composition. The results are compared with the earlier obtained computational results for a zero friction coefficient. It is found that resistance to penetration and penetration depth can be described using binomial Resale's penetration law with a quadratic velocity. The disagreement between the forces of resistance to penetration of a pyramidal, conical and star-shaped bodies of the same height are within the interval of 10-20%.


The crystal and molecular structures of the β-polymorphic forms of phthalocyaninatomanganese(II), [Mn(pc)], and phthalocyaninatocobalt(II), [Co(pc)], have been determined by single-crystal X-ray diffraction methods at 295 K, and also at 116 K in the case of [Mn(pc)]. Crystals are of the monoclinic β-polymorph type, space group P21/c, Z= 2; for [Mn(pc)](116 K), a= 14.590(3), b= 4.741(1), c= 19.301(5)A, β= 120.79(1)°; (295 K), a= 14.576(5), b= 4.755(1), c= 19.362(7)A, β= 120.70(2)°; [Co(pc)](295 K), a= 14.542(2), b= 4.773 1(5), c= 19.352(2)A, β= 120.824(7)°. Automatic diffractometry has provided significant Bragg intensities for 1 608 {[Mn(pc)], 116 K}, 1 525 (295 K), and 1 930 {[Co(pc)]} independent reflections and the structures have been refined by full-matrix least-squares methods to R 0.038 {[Mn(pc)], 116 K}, 0.072 (295 K), and 0.039 {[Co(pc)]}. The metal atoms co-ordinate within the central cavity of the macrocyclic phthalocyaninate ligand to a precisely planar array of nitrogen atoms, with mean bond lengths Mn–N = 1.941(3)A at 116 K, 1.933(5)A at 295 K, and Co–N 1.908(2)A. The intermolecular packing is of the typical herringbone arrangement, with angles of 47.9 {[Mn(pc)], 116 K} and 47.3°{[Co(pc)]} between the normals to the MN4 co-ordination planes and the crystallographic b axes. Each molecule has close contacts with two neighbours related by translations of ±b, resulting in pseudo-octahedral metal environments with axial Mn–N contacts of 3.150(3)(116), 3.169(6)A(295 K), and a Co–N contact of 3.219(3)A. The importance of these intermolecular contacts in establishing a ferromagnetic exchange path in [Mn(pc)] is discussed, as are deviations within the macrocyclic ligand from D4h symmetry.


KLCOVANSKA, Veronika, Bc.: Analysis of the evolution of taxation in the Slovak Republic. [Bachelor thesis]. Banking Institute University of Prague, Foreign University Banska Bystrica. Department of Finance, Accounting and Insurance. Supervisor: Ing. Lenka Ostrožlikova. Year of defense: 2013. Number of pages: 60. The thesis is focused on the development of taxation in the Slovak Republic with accent on the impact of the crisis on tax revenues. It consists of three chapters. The first chapter is devoted to the theoretical definition of basic economic concepts that inherently belong to the research problems. The second chapter deals with the general characteristics of the taxes of their dividing, but the most important part of this chapter is a detailed overview of the development of the tax system of the Slovak Republic from its inception to the present, including tax changes effective from 1 January 2013. The third chapter analyzes the development of tax revenues accruing to the state, as well as local budgets in relation to the appearance of crisis in Slovakia.


The purpose is to describe and explain the pronounced and changing specialisations of six European countries in terms of both trade and technology. The explanation starts from Pavitt's categorisation of technological families, showing how it can be refined to describe sub-families and how the categories evolved. The task is (a) to define what are the requirements for success in innovation in each category, (b) to assess each country's capacity to meet those requirements. Six behavioural requirements are postulated: two types of inter-functional coordination; external interaction; and three types of vertical interaction. There are also three external requirements: science base, technical manpower, and patient money, of various types. It is shown how these requirements appear to vary among families, sub-families and sectors, and how countries appear to vary in their ability to meet them. This explains satisfactorily the pattern of specialisation, and direction of change, which is described.


Abstract Background The use of second-generation antipsychotic (SGA) medication among child and adolescent psychiatric patients has increased worldwide in recent years. The increase appears to have been more extensive in the USA than in European countries, but the tendency is similar. However, after a peak the use seems to have declined in the USA. Simultaneously with the increasing numbers, the duration of SGA use has lengthened, indications have broadened, and off-label use has increased. Despite existing follow-up recommendations and evidence for the metabolic adverse effects of SGAs in children, research evidence has not translated into clinical practice. Objective The aim of this study was to assess the clinical use and follow-up practices of SGA medication among child psychiatric patients of one university hospital in Finland. Method This retrospective patient report-based study was conducted at the Child Psychiatric Clinic of Tampere University Hospital, Finland. The study sample consisted of 133 patients who were younger than 13 years when initiating SGA treatment and had an ongoing SGA medication during the study period. The study sample was divided into two groups according to diagnosis to examine whether there were differences between patients with an autistic or a developmental disorder (F83-84) and patients with other psychiatric diagnoses. Results: This study showed that SGA use in children younger than 13 years was mainly off-label. Irrespective of diagnosis, the most common indication was aggression. Especially children with psychiatric diagnoses other than developmental disorders had multiple socio-demographic risk factors and adverse life experiences in their background. The follow-up practices were diverse and partly irregular. Conclusions: A need for systematic SGA monitoring practices and dialogue between the medical specialities treating children and their families is evident.


The paper deals with the increase of protection systems' efficiency by means of the Honeypot technology. The design principles of this technology are described. We propose several ways of the file storages effective organization. Plans of collecting statistical information on malefactor's actions are discussed. Also the efficiency of the suggested approach is estimated.


This article analyzes the interpretation of the theme of family and family line in the works of V. Aksenov, L. Ulitskaya and in modern mass literature. The author uses the comparative-historical and integral method of analysis of a literary work. It has been established that the theme of the family line in modern prose is localized in the «family» stories as «small» forms of family line history. The concept of «family line» implies the traditional values: the importance of genetic memory, home, family, procreation, responsibility to the ancestors and to future generations. The category of family line is extended by introducing parallel storylines of children born out of wedlock and the motifs of «serial monogamy», «alleged paternity» in the novels of contemporary fiction writers. Most often, the theme of family line degeneration in modern prose is expressed through the violation of moral norms by protagonists, their breaking away from the roots and from the past. This theme is also directly connected with the motif of ancestral curse.


Tracking ground support equipment (GSE) in a high accuracy manner is crucial for both airport safety and optimal management of airport assets but the related researches and products are scarce. Tracking a multi-carriage logistics train is obviously most challenging compared with other single-carriage GSE. In this paper, we design a real-time on-board positioning and heading system (ROPHS) to obtain the real-time status of a multi-carriage logistics train which consists of a powered leading vehicle and one or several non-powered trailing vehicles. The status includes: (a) the accurate positions and velocities of any points on this train, and (b) the alterable number and linking sequence of trailing vehicles at any time of a trip. Technically, the hardware of the system relies on real-time kinematic (RTK) to obtain geolocation of the leading vehicle, and on gyroscopes, magnetometers and accelerometers to obtain headings of all vehicles. A geometry based recurrence algorithm is afterwards presented to calculate the positions of any trailing vehicles. In the end, the multiple model based tracking algorithm is proposed to compute the precision-improved locations and real-time velocities of the whole train. Different from existing traditional GPS or RFID based positioning techniques, the proposed system can reach centimeter-level accuracy, which enables collisions detection, especially those latent collisions that cannot be easily monitored or foreseen by crews' visual inspection.


The present invention discloses a chlorine-containing mixed aminopyralid herbicide fenoxaprop and belongs to the technical field of pesticide. The herbicides aminopyralid and fenoxaprop-P as the main active ingredient, the mass ratio of aminopyralid and fenoxaprop-P is 0.1 to 80: 0.1 to 80. Mixed herbicides of the present invention in non-cultivated land, orchard, forest, field wheat, canola and corn field in postemergence field, has a quick, wide herbicidal spectrum, long duration, herbicidal thoroughly, low residue, low toxicity, safety and environmental protection, etc., is the quality of non-arable land, orchards, forests, wheat fields, corn fields and rapeseed field chemical herbicides.


Contamination of heavy metals such as Cu2+ and Pb2+ have become serious problems in the aquatic ecosystems. Various efforts to prevent the negative impacts of pollution are being conducted. One of the crucial efforts is to monitor the concentration of heavy metals in aquatic ecosystems. However, the monitoring the heavy metal concentration faces various obstacles, particularly in the lotic ecosystems such as river due to the water flow. This study aims to analyze the utilization of biofilm matrix as a biological agent in the monitoring of river ecosystems. The study focuses on Cu2+ and Pb2+ in the Cokro River of Malang City. The concentration of Cu2+ and Pb2+ were measured in the river water, sediment and biofilm. The environmental parameters those analyzed were temperature, pH of bottom sediment, pH of water, current speed and water depth. The results of this study reveal that the concentration of Cu2+ and Pb2+ inside the biofilms were much higher compared with those of in the sediment and river water. According to the results of this study, the biofilm matrix is a promising biological agent to monitor the Cu2+ and Pb2+ concentration in the lotic ecosystems such as Cokro River.


As like the other sectors, the health sector also has a huge amount of data that should be utilized for handling the different diseases. One of the increasing diseases is the diabetes that can be handled if it is detected at an early stage. For this purpose, the algorithms of ML can be used. We have discussed the various algorithms of ML and the attributes that can be used to train these algorithms for detecting the diabetes.


The evaluation of performance parameters of modern data transfer networks is a crucial matter to arrange flow route selection and flow control. In this paper formulae which allow to calculate the average cost of increment of predicted total packet delay caused by accepting a certain packet coming to the data communication system have been derived. Moreover using the obtained results some algorithms for input flow control have been suggested.


•  Introduction •  Death receptor signalling •  TNF‐R1 signalling •  CD95 signalling •  TRAIL‐R signalling •  Targeting death receptors in cancer therapy •  Targeting TNF‐R1 ‐  Isolated limb perfusion (ILP) ‐  Cell surface antigen‐restricted activation of TNF‐based fusion proteins ‐  Use of PEGylation to improve the specific anti‐tumour effect of TNF ‐  Tumour targeted gene delivery of TNF •  Targeting CD95 ‐  Tissue‐specific features of agonistic CD95 antibodies ‐  Cell surface antigen‐restricted activation of CD95L‐based fusion proteins ‐  CD95L‐based gene therapy •  TRAIL as a target for anti‐cancer therapy ‐  TRAIL‐receptor agonists and their toxicities ‐  Responsiveness of primary tumour cells to TRAIL‐mediated apoptosis ‐  Sensitization to TRAIL ‐  Clinical application of TRAIL‐R agonists •  Future perspectives


Dr. Stewart served as discussant for the Santa Fe paper session "Working On, Working For, and Working With American Indians" from which this special issue of PA is drawn. His most visible applied anthropology role has been as expert witness. He reports that between 1950 and 1983 he testified in numerous Indian Claims cases on behalf of the Chippewa, Shoshone, Ute, Southern Paiute, Northern Paiute, Klamath, Washo, Gosiute, and Indians of California, helping these groups receive awards from the Indian Claims Commission in excess of $200 million. Most recently, he was involved in the San Juan Southern Paiute effort to obtain federal acknowledgement as a tribe. However, Dr. Stewart is best known for his testimony on behalf of members of the Native American Church who have sued state courts for the legal right to practice the peyote religion openly. His work in this area has spanned the thirty years from 1960 through the present. Dr. Stewart discussed the origins of anthropological concern with the peyote reli...


Osteoma of temporal bone predominantly arises from external auditory meatus followed by mastoid and temporal squames. They usually present as cosmetic deformity or are incidental findings on radiological investigation. Surgical excision is the treatment of choice. A case of osteoma, developing in mastoid cavity is being reported for the first time from India.


Biology and Earth science have always been linked during the history of the French educational system. As a result, the school subject today is called "Life and Earth Sciences" in which biology represents approximately 2/3 of the content. Thus, the teacher training courses involve both Biology and Earth Science subjects. Life and Earth sciences are a mandatory core subject in secondary schools and the objectives and the content of the courses are set by a national curriculum. In France at the lower secondary level, the main objectives of biology teaching are understanding how the human organism operates and the organisation of the environment in order to lead children to responsible behaviour in health care and environment preservation. Another main objective is that students should become open-minded and critical of the information transmitted by the media. At higher secondary level the objectives are very similar: to encourage citizenship based on scientific knowledge and methods, and to prepare the students for further science education. Because of the decrease in the number of students who choose science studies after higher secondary school, biology teaching, like other scientific subjects, has become a priority today in France. We have to make biology teaching more attractive and more useful to help students to choose a scientific career. In my presentation I will develop these topics and try to answer some questions about biology teaching in France: WHO is teaching biology (teacher training)? WHAT is taught (the subjects)? HOW MANY hours are devoted to biology at the different levels? WHY is biology taught (the objectives)? HOW is biology taught (the methods)?


The invention provides an aluminium alloy for a vehicle hub and a preparation method thereof. The alloy comprises the following components by weight percent: 4.5-6.3% of Zn, 1.4-2.5% of Mg, 0.5-0.9% of Cu, 0.12-0.3% of Zr, 0.05-0.15% of Ti, 0.05-0.2% of Cr, 0.1-0.3% of Sc and the balance of Al. The preparation method of the aluminium alloy comprises the following steps: weighting raw materials, melting the raw materials except for magnesium blocks, adding a covering agent, then adding the preheated magnesium blocks, stirring, injecting nitrogen or argon to degas, filtering with a ported ceramic plate, reducing the temperature, standing for 20 minutes, and adopting a liquid forging mould and a liquid forging forming method to prepare the hub. The prepared vehicle hub has high strength, impact toughness and corrosion resistance; and the mechanical properties of the aluminium alloy hub can be ensured, the production cost can be reduced and the large-scale production of the hub is easy to perform.