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MRI-Guided Laser Surgery and Doxorubicin Hydrochloride in Treating Patients With Recurrent Glioblastoma Multiforme
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01851733
Recruitment Status : Completed
First Posted : May 10, 2013
Last Update Posted : August 27, 2021
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Device: MRI-guided Laser Heat Ablation (MLA) Drug: Doxorubicin Other: Blood draw - dendritic cells Device: Dynamic Susceptibility Contrast Magnetic Resonance Imaging
|Phase 1
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|37 participants
|Intervention Model:
|Parallel Assignment
|Single (Investigator)
|Primary Purpose:
|Official Title:
|A Pilot Study of Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Doxorubicin in the Treatment of Recurrent Glioblastoma Multiforme
|Actual Study Start Date :
|August 13, 2013
|Actual Primary Completion Date :
|April 12, 2018
|Actual Study Completion Date :
|May 30, 2018
Experimental: Arm B: (MLA, doxorubicin hydrochloride at 6-8 weeks)
Device: MRI-guided Laser Heat Ablation (MLA)
Drug: Doxorubicin
Other Name: Adriamycin®
Other: Blood draw - dendritic cells
The second 10 patients enrolled to Arm B:
Device: Dynamic Susceptibility Contrast Magnetic Resonance Imaging
Other Name: DSC-MRI
Experimental: Arm C: (MLA, doxorubicin hydrochloride at 72 hours)
Device: MRI-guided Laser Heat Ablation (MLA)
Drug: Doxorubicin
Other Name: Adriamycin®
Device: Dynamic Susceptibility Contrast Magnetic Resonance Imaging
Other Name: DSC-MRI
- Ktrans from DSC-MRI [ Time Frame: 6 weeks ]Using a 2 compartment model to calculate a the vascular transfer constant (Ktrans) which will provide a quantitative measure of blood brain barrier leakage
- Peritumoral permeability scores, measured by DSC-MRI and serum biomarkers [ Time Frame: 6 weeks ]Pearson correlation coefficient (r) will be determined for each biomarker and Ktrans value. A minimum r=0.5 is required for inclusion for further analysis and will be used as a peritumoral permeability score. This score will then be correlated with the patient outcome data to determine whether it has a predictive value.
- 6-month PFS (rate) [ Time Frame: 6 months ]Assessed using RANO Response criteria. A log-rank test will be used to compare 6-PFS of Arm B and of Arm C to historical controls.
- Overall Survival [ Time Frame: 2 years ]Date began MLA treatment to date of death from any cause. A log-rank test will be used to compare OS of Arm B and of Arm C to historical controls.
- Quality of Life [ Time Frame: 2 years ]Using Karnofsky performance status and the mini-mental state evaluation to assess patient overall response to treatment.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria - Arms B and C:
- Histologically confirmed GBM; rare GBM variants, secondary GBM, and suspected secondary GBM are allowed.
- Unequivocal evidence of tumor progression by magnetic resonance imaging (MRI) scan.
- There must be an interval of at least 12 weeks from the completion of radiotherapy to study registration except if there is unequivocal evidence for tumor recurrence per RANO criteria. When the interval is less than 12 weeks from the completion of radiotherapy, the use of PET scan is allowed to differentiate between unequivocal evidence of tumor recurrence and pseudoprogression.
- Candidate for MLA based on size, location, and shape of the recurrent tumor as determined by the performing neurosurgeon
- At least 18 years of age.
- Karnofsky performance status ≥ 60%.
- Scheduled for MRI-guided Laser Ablation (MLA).
- Normal left ventricular ejection fraction on MUGA or echocardiogram within the past 1 year prior to registration for patients with history of congestive heart failure and/or coronary disease requiring medications other than aspirin, or known prior exposure to anthracycline chemotherapy.
Adequate bone marrow and hepatic function as defined below (must be within 7 days of MLA):
- Absolute neutrophil count (ANC) ≥ 1500/mcl (G-CSF is allowed)
- Platelets ≥ 100,000/mcl
- Hemoglobin ≥ 9 (pRBC transfusion +/- ESA are allowed)
- ALT ≤ 3 x ULN
- AST ≤ 3 x ULN
- ALP ≤ 3 x ULN. If ALP is > 3 x ULN, GGT must be checked and be ≤ 3 x ULN.
- Bilirubin ≤ 2 x ULN
- At the time of registration, patient must have recovered from the toxic effects of prior therapy to no more than grade 1 toxicity.
- At the time of registration, patient must be at least 2 weeks from prior vincristine, 3 weeks from prior procarbazine, and 4 weeks from other prior cytotoxic chemotherapy.
- Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control, abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she must inform her treating physician immediately.
- Ability to understand and willingness to sign an IRB approved written informed consent document (or that of legally authorized representative, if applicable).
Exclusion Criteria - Arms B and C:
- Prior treatment with doxorubicin and/or bevacizumab.
- Prior treatment with Gliadel wafer is allowed if it has been at least 3 months from placement.
- Previous treatment with complete cumulative doses of daunorubicin, idarubicin, and/or other anthracyclines and anthracenediones that is equivalent to a total dose of 240 mg/m2 doxorubicin.
- More than 2 prior relapses.
- Currently receiving any other investigational agents that are intended as treatments of GBM.
- A history of allergic reactions attributed to compounds of similar chemical or biologic composition to doxorubicin or other agents used in the study.
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, recent heart attack within the previous 12 months or severe heart problems, or psychiatric illness/social situations that would limit compliance with study requirements.
- Pregnant and/or breastfeeding. Premenopausal women must have a negative serum pregnancy test within 14 days of study entry.
- Inability to undergo MRI due to personal and medical reasons.
- Known history of HIV or autoimmune diseases requiring immunosuppressant drugs.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01851733
|United States, Missouri
|Washington University School of Medicine
|Saint Louis, Missouri, United States, 63110
|Principal Investigator:
|Milan Chheda, M.D.
|Washington University School of Medicine
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Washington University School of Medicine
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|May 10, 2013 Key Record Dates
|Last Update Posted:
|August 27, 2021
|Last Verified:
|August 2021
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
|Product Manufactured in and Exported from the U.S.:
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Antibiotics, Antineoplastic
Antineoplastic Agents
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action


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Getter and Ghostemane make an extraordinary match in their brand new Dahlia I EP, which delivers three riveting hip hop tracks that we can't get enough of!
These guys go in hard on the first track and don't ever let up. First up, "Hack:Slash" boasts a fierce, striking beat stacked up against some absolutely insane bars. Just 1:32 seconds into the EP and we definitely have some mixed feelings — "Hack:Slash" is really sick, but why the hell did they end the track so prematurely? Either way, with little warning, Getter and Ghostemane have our full, undivided attention.
"Grain" and "Beware: The Sirens" do their damnedest to make sure we have our Getter x Ghostemane fix, but a full listen through Dahlia I will only prove you need to listen again. It's short, savage, and insanely repeatable.
Let's hope the "I" in Dahlia I means this is the first of a series of EPs that Getter and Ghostemane release together — because hip hop needs more of what these guys are serving up!
Out now via Shred Collective

subset: commoncrawl


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They grew up watching and idolizing Chicago Blackhawks stars such as Bobby Hull, Stan Mikita and Tony Esposito.
They cheered and celebrated when Team USA defeated the Soviet Union in the game tabbed the "Miracle on Ice" en route to winning the gold medal at the 1980 Winter Olympics.
And they quoted lines from "Slapshot," the 1977 comedy featuring the Charlestown Chiefs and player-coach Reggie Dunlop, played by Paul Newman.
Newman was in his early 50s during the filming of "Slapshot." Well, the men you're about to meet are continuing to play, and to enjoy a love affair with the sport of ice hockey well past that age.
A higher calling
From mid-October to mid-May, the 30-or-so fellows 50-and-over who play hockey at the Winnetka Ice Arena lace up their skates every Sunday morning and are ready to go at 6:45 — earlier than most early church services. They usually play three 5-goal games within a time allotment of 80 minutes.
"People ask me if I go to church on Sunday; I say, 'Yes I do. I go to the Winnetka Ice Arena every Sunday morning,'" Randy Lauer, 58, of Winnetka, says with a laugh.
Lauer, who makes out the lineups for Sunday's game between the two squads (red and white) every Saturday night, wants to follow in the footsteps of his late father, Chuck, who played until age 65.
"That's my benchmark right now," says Lauer, past president of the Winnetka Hockey Club who played hockey at New Trier West, Lake Forest College and also was part of the Marine Corps hockey team in San Diego when he served in the U.S. Marines. "We'll get there and see how we feel."
Tom Gullen, a Winnetka Park District retiree who ran the rink at the Ice Arena for 35 years, has been playing on Sunday mornings for around 20 years.
"I get up every morning this early so this isn't a big deal," says Gullen. "I use the adage, 'I never slowed down because I never sped up in the first place.' "
Gullen, 59, says when players reach his age "you've got to accept that there are some things you used to do (on the ice) that you can't do. (But) every once in a while you make a play that makes you feel good, and it's fun to set up a nice goal or make a nice assist."
While love of the game is a big reason why these 50-somethings (and even 60-somethings) continue to skate, shoot and score, to a man — whether at the Winnetka Ice Arena or further south at Rocket Ice in Bolingbrook — they'll tell you it's the camaraderie and friendships that keep them coming back.
"It's a great bunch of guys, it really is," says Keith Jutkins, 62 years young, referring to those he plays alongside —and against — in the Rocket Ice's Hockey Five-O league for players ages 50-and-over. Teams take the ice every Friday night from mid-September to mid-December, and again from early January through mid-April.
Jutkins plays for the Geri-Hat Tricks — one of four squads in the league along with the Grey Wolves, Pond Hockey and Rusty Blades. Each game consists of three 15-minute periods and is officiated.
"They're all good guys; we all know each other," adds Jutkins, who after one recent game brought pork loins for his team and the opposing team "for some post-game camaraderie" and a late-night dinner.
"We're competitors on the ice, but off the ice it's the camaraderie of it," he says.
Both Jutkins and Mark Huppertz of Bolingbrook, captain of the Wolves, have competed in Hockey Five-O since the league's inception four years ago, with both returning to play after years away from the ice thanks to this league.
"It's physically challenging, but it really, really keeps you young and really keeps you in physical shape," says Huppertz, who played prep hockey at Homewood-Flossmoor and club hockey at Illinois State.
Huppertz has been playing throughout the fall and winter with a meniscus tear — the NHL would call it a lower body injury — but he's not about to shut himself down for the rest of the season… and he plans on playing long after this season is over.
"I'd like to continue playing until I can't play anymore," he says. "There's the element of camaraderie, and it really, really does keep you young."
The younger guys
Thursday nights at Johnny's IceHouse in Chicago, just a few blocks east of the United Center, is where Mike Vasilevich dons his Chicago Sharks uniform. The Sharks are comfortably in first place in the five-team Over-40 Elite League.
Vasilevich has been playing Over-40 Elite hockey for six years now, but here's the rub: he's over 50. In fact, he's 55.
"I would say probably 45 is median age; a couple of guys (are) in their 60s and several in their 50s," says Vasilevich, who has an impressive hockey resume that includes stints in minor and Junior A hockey, three years in upstate New York as a member of the SUNY Brockport College hockey team and a season in the old Atlantic Coast League with a club called the Troy Slapshots.
"We're a bunch of old guys but it's very competitive," he says. "We've been playing against each other for so long."
When asked what it's like to compete against younger players, Vasilevich replied, "It's very challenging. Just the speed of the game now is so much faster, the equipment is better, the players are more skilled and taught better and the coaching is much better."
An added perk of playing in this league is going up against some onetime professional players. For example, Brian Noonan and Reid Simpson, both former Chicago Blackhawks, skate with the Chicago Chargers.
"All in all, they're just good guys," Vasilevich says. "At the end of the day we're all buddies. It's just the drive to keep playing as long as we can and as long as we're all healthy."


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August 21, 2019 In News
Student Services First Week of School Extended hours
Student Services Extended hours
August 26-29th
Friday 7:30am-4:30pm
Student Wireless Network
To log in to Taft College\'s wireless network, enter your A Number for the User ID and your Password is your first initial capitalized followed by your last name initial and the last 6 numbers of your A Number.
Example: Student Tom Jones with an A Number of A0002005 would use A0002005 for the User ID and Tj002005 for Password.
Taft College Help Desk
Taft College ITS Help Desk ticketing system.
Student Services Extended hours
August 26-29th
Friday 7:30am-4:30pm


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Sweet smell for Hickman in home finale
Kewpies snap losing streak in time for districts
Cray Logan wanted his team to remember the smell.
The Hickman coach still remembers the smell of the old Hickman gym during his last game as a player for the Kewpies in 2007. Now coaching the Kewpies, Logan wanted to make sure his seniors remembered the smell of their last home game as well.
"What I wanted from them is to leave a smell that they can come back to years and years and years down the road," Logan said.
Whatever scent was wafting through the air during Friday night's matchup between the Kewpies and Fort Zumwalt North will bring back pleasant memories for the team's six seniors, as Hickman held off the Panthers, 74-65.
From the start, it was clear Hickman's game plan was centered around Fort Zumwalt North's Mujtaba Alkhaldi. Standing at 6-foot-6, Alkhaldi outsized the closest Kewpie by two inches. In terms of Hickman's starters, he expanded his height advantage to four inches.
Hickman started the game with 6-foot-2 Jarvis Jennings positioned on the Panthers' big man. After picking up a quick foul, Jennings settled in, not allowing Alkhaldi to back his way to the rim.
The Kewpies proceeded to give Alkhaldi different looks throughout the night, sometimes switching into a 2-3 zone to push him out of the floor's center, other times matching him up with Nate Wilson and Roman Canty, both of whom stand 6-foot-4. The constant change appeared to throw Alkhaldi off balance, as the Fort Zumwalt North post player finished with 12 points, none of which came in the fourth quarter.
"With an excellent big like he is, my biggest goal is to try to find a weakness," Logan said. "A lot of times when you find a talented big like that with great footwork, they don't like to run up and down the floor as much as we do."
To limit Alkhaldi's effectiveness on defense, the Kewpies pushed the ball up the floor as quickly as possible when in transition. The up-tempo game suited Jennings, as the Hickman guard slashed his way to the rim time after time to lead all scorers with 28 points.
Still, despite its focal point on both sides of the ball being minimized, Fort Zumwalt North never let the Kewpies fully pull away. After leading by 10 points at halftime, Hickman's lead was closed to just four points at the end of the third quarter.
With Alkhaldi out of the equation, the Panthers turned to guards Grant Rapplean and Kyle Bampton. The pair had opposite playing styles, with Rapplean shooting from the perimeter and Bampton bullying his way to the basket, but both were equally effective. Rapplean finished with 17 points while Bampton added 16 of his own.
It was Bampton who quieted the crowd with just over four minutes left in the game by making a layup despite being fouled and converting the ensuing free throw to tie the game at 56. Logan immediately called a timeout.
When he looked around the huddle, he didn't see panic. His team had been in this position before this season.
"You can see it in our record right now that we've lost games by very very close margins," Logan said. "So really now, it's, 'We've been here before, you know what that's like, let's bring this one home.'"
Hickman and Fort Zumwalt North answered each other shot-for-shot as the clock ticked down. It wasn't until the Kewpies' Caillou Naylor made a layup despite Alkhaldi being draped all over him that Hickman managed to pull away.
From that point, Fort Zumwalt North was forced to foul. Jennings iced the game with 51.9 seconds to go to put Hickman up 71-65.
The win rescues the Kewpies from an eight-game losing streak just in time for district play. Hickman (8-16) is matched up with Raymore-Peculiar in the opening round of the Class 5 District 9 bracket on Tuesday.
"Tomorrow, we've got to forget about it," Jennings said. "Celebrate tonight but at 9 a.m. tomorrow morning, we've got to forget about it, realize we're 0-0 again and that anything can happen. We've got to prepare for a big game on the 26th."


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Mar 13, 2012
MDS Tuesday
Hello Peeps !!!
Happy Tuesday !!!
I decided to work on some cards using the MDS Doily using the IN Colors- Island Indigo, Pool Party and Wisteria Wonder. I shrunk the center doily and embellished it with designer brads. I framed the sentiment using the large and scallop oval punch and also used In Color DSPs. Hope you like it.
Stamps: MDS, Petite Pairs
Paper: Whisper White, In Color DSPs
Ink: Pool Party, Island Indigo, Wisteria Wonder
Accessories: ruffled ribbon, designer brads
Tools: circle punches, scallop ovan and large oval punch, dimensionals
Thansk fro stopping by.
Have a wonderful day stampin'
Posted by Me, My Stamps and I at 8:49 AM
Labels: MDS, MDS Tuesday
6 comments:
- Julie A. said...
Hi Chat! This is a gorgeous set of cards!!! Would you believe I actually don't have the Hello Doily stamp yet? It's on my wish liist and I will be getting it soon:) Thanks so much for sharing your beautiful work:)
- March 13, 2012 at 1:07 PM
- Allison said...
These look so beautiful! Love the pool party one especially!
- March 13, 2012 at 1:55 PM
- Paper Potter said...
What a perfectly gorgeous set of cards!!!
- March 14, 2012 at 4:51 AM
- Judy Rozema said...
Ah these are gorgeous!!
- March 15, 2012 at 6:37 AM
- Penny Hanuszak said...
I never really thought too much of this stamp until I saw your beautiful cards. Now of course I have to have it! Thanks for sharing your gorgeous creations.
- March 23, 2012 at 1:39 PM
- Christine K said...
Thanks, Chat, for letting me CASE!
Here's my version:
- April 3, 2012 at 1:47 PM
Subscribe to: Post Comments (Atom)


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Colloid Cyst of the Third Ventricle Presenting with Features of Terson's Syndrome
Mary K Jacob1, SK Anand1, Prasad George2
1 Department of Ophthalmology, Nizwa Hospital, Ministry of Health, Sultanate of Oman2 Department of Medicine, Nizwa Hospital, Ministry of Health, Sultanate of Oman
Correspondence Address:Mary K JacobDepartment of Ophthalmology, Nizwa Hospital, P.B 1222, Nizwa 611, Sultanate of Oman Source of Support: None, Conflict of Interest: NoneCheckDOI: 10.4103/0974-9233.142275
Source of Support: None, Conflict of Interest: None
This report describes a middle-aged man presenting to the ophthalmologist with history of seeing floaters before both eyes since 2-weeks duration. A history of intermittent headache and dizziness of recent onset was elicited on questioning. Ocular examination showed bilateral early papilloedema and mild vitreous hemorrhage. Brain computed tomography (CT) disclosed features suggestive of colloid cyst of the third ventricle in the region of foramen of Monro with moderate hydrocephalus. Emergency craniotomy and excision of the cyst was done, and the patient is doing well for the last 18 months after the surgical intervention. The mechanism of this presentation, importance of early investigations, and timely intervention are highlighted in order to avoid serious neurological sequelae. The literature was extensively reviewed for atypical presentations of intraventricular colloid cyst.
Keywords: Colloid Cyst, Obstructive Hydrocephalus, Third Ventricle, Vitreous Haemorrhage


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Signed in as:
Signed in as:
Ron has 30 years of detailed knowledge and earned experience in the life insurance and wealth management industry. He has held management positions at the world's top insurance companies and helped grow a number of nationally recognized producer groups. His philosophy includes leveraging macro views of financial planning in order to develop specific wealth building and capital preservation strategies for clients. Ron prides himself on considering each client's specific goals and unique values to plan accordingly. In his leadership role at the National Network of Accountants, Ron's goal is to help grow and enhance NNA's relationships with accountants, accounting firms and other professionals. In addition to traditional methodology, Ron utilizes all aspects of digital communications and marketing to enhance advisors and clients overall experience with the firm. Ron is also an accomplished author, having penned a popular book, Invest In Your Life: Why Wall Street Wants You – an insider's look into the issues regarding the sale of life insurance policies to secondary investor groups. He has over the years also been a regular contributor to several nationally recognized industry publications, including The CPA Journal, The National Underwriter, and The Journal of Accountancy. He received a B.A. from The George Washington University in 1988, and then went on to earn the industry-respected Chartered Life Underwriter and Chartered Financial Consultant designations from The American College in Bryn Mawr, PA. Ron also serves on the prestigious International Advisory Committee for EcoPeace Middle East – a unique organization that promotes peace in the Middle East based upon the common need for water and other natural resources. Ron resides in Upper Brookville, NY with his wife Claudia and his children Zachary & Hanna.
National Network of Accountants
6900 Jericho Turnpike, Suite 300 Syosset, NY 11791 US and 15 North Main St, Suite 100, PMB 714, West Hartford, CT 06107.
Copyright © 1992 National Network of Accountants - All Rights Reserved.


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Civil Rights
Block on Trump's Asylum Ban Upheld by Supreme Court
The Eighth Circuit's Court of Appeals affirmed a lower court ruling against Hasenwinkel, a registered nurse who sued her former employer on claimed violations of the Family Medical Leave Act (FMLA).
In affirming the lower court's decision, the circuit court found that not only did Hasenwinkel's employer comply with federal law, but that it gave her three times more time than was required under the FMLA.
Bonnie Hasenwinkel was hired as a nurse in the summer of 2007 by Mosaic, a company that operates in-home care and nursing-care facilities for adults with mental disabilities. While employed with Mosaic, Hasenwinkel obtained FMLA leave on seven different occasions. The following is taken verbatim from the circuit court's opinion:
"Hasenwinkel took continuous periods of FMLA leave to have knee
surgery (March 4 to 17, 2010), treat depression (April 7 to 24, 2011), undergo a heart
procedure (July 27 to August 7, 2011, and October 4 to October 16, 2011), and
recover from neck surgery (November 23, 2011, to April 2, 2012). She also took
intermittent FMLA leave to attend physical therapy (June 18, 2009, to June 17, 2010)
and to care for her ailing father (January 10, 2011, to January 9, 2012)."
Hasenwinkel claims that in the Summer of 2011, she was asked to return to work after she requested FMLA leave in order to treat her chronic depression. In the coming years, her performance at work declined. When she left for neck surgery, she never returned to work. Even with an additional 12 weeks of FMLA leave given to her do to a serendipitous company restructuring of its FMLA policy, she was never well enough to return to her position. Mosaic fired her in 2012.
Under the FMLA, federal law requires that certain eligible employees (of which Hasenwinkel was one) are allowed 12 weeks of requested unpaid leave under certain circumstances, including the birth of a child, debilitating illness of a family member, or the development of a medical condition that would essentially make it impossible for the employee to return to work.
During this time, an employer may not retaliate or terminate the employee's position unless the employee exhausts her 12 weeks' time and still cannot return to work. At that point, termination is permissible under the Act.
In Hasenwinkel's case, the court found that Mosaic never denied her leave requests and that, in fact, Hasenwinkel was afforded approximately three times about the time she was entitled to under the Act. She was, in fact, able to use the additional twelve weeks she had stumbled into in 2012 recuperate. In that time, however, she did not recover sufficiently from her neck surgery. Thus, Mosaic's termination of her employ, coupled with her diminishing performance, was justified.
A basic sum total of the hours would have revealed that Hasenwinkel did not have a foot to stand on to bring a FMLA case against Mosaic. It demonstrates that even with leave requests generously being given out, employers must always be vigilant to respond to various employment suits.
Related Resources:
Meeting with a lawyer can help you understand your options and how to best protect your rights. Visit our attorney directory to find a lawyer near you who can help.


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Day 61: Two Random Variables Q2
For those of you who have been following along, today we are going to post another question and in the next post we will give the solution. This will be another two random variable question and we've covered everything you need to solve it in our previous posts. So with that, let's get to today's question.*


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Multi-day tours, designed to complement your academics and enhance your cultural immersion, are included in all of CIEE's Open Campus Block programs!
The city of Bath, which has been a World Heritage site since 1987, is located in the county of Somerset, in South West England. It is well known for its Roman built baths and 18th- century Georgian architecture. Bath was founded by the Romans in the 1st century AD. The Romans used the natural hot springs as public Baths. During the Middle Ages, the city became important for the wool industry, but it wasn't until the 18th century under the reigns of Kings George I, II and III that it really emerged as an elegant spa city and became known for literature and art. The city became fashionable and the population grew. Jane Austen lived in Bath in the early 19th century. Further building was undertaken in the 19th century and following the Bath Blitz in World War II.
The Roman remains, especially the Temple of Sulis Minerva and the baths complex, are amongst the most famous and important Roman remains north of the Alps. Our study tour will include a visit to the Roman Baths complex which is still located in the heart of the city. Bath is also well known for its architecture and this you will be able to see during the tour of the city and throughout our stay. Honey-coloured Bath stone has been used extensively in the town's architecture, including at Bath Abbey, the Royal Crescent, Circus, Pump Room and Assembly Rooms. Significant individuals who are associated with the design and layout of city include John Wood Senior and Richard 'Beau' Nash.
Visti the historic Pulteney Bridge built in 1774 with notable architecture & rows of stores lining each side, or explore museum throughout Bath including the Holburne Musuem, the Victoria Art Gallery, and the Jane Austen Centre.


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Construction may have caused carbon monoxide leak
A Rochester family has been displaced from its home, and fire department officials are looking at construction in the area as a possible cause.
First responders were called about 12:25 a.m. today to the 4200 block of Dodge Lane Northeast, where they found elevated levels of carbon monoxide — 100-150 parts per million — in the house.
Firefighters went through the home looking for a source, said Larry Mueller, assistant fire marshal for the Rochester Fire Department. The appliances were all fine, he said, but the sump pump appeared to be the source. The pump was disassembled and the area was covered with plastic.
Construction crews are blasting land in the area, officials learned, possible sending the odorless, colorless gas through the ground into the home.
About 6:25 a.m., firefighters responded again to the home for a carbon monoxide alarm. This time, Mueller said, there were about 50 ppm of the gas throughout the home.
Officials checked two additional homes in the area to measure for the presence of the deadly gas, but detected none, he said.
The homeowners have been advised to leave the home and stay away until a source is confirmed and the levels have dissipated.
Mueller said they'll discuss the situation with the construction crews.
"We sometimes see other gases, like methane, come through as a result of blasting, but we've never seen carbon monoxide like this," he said.
The health effects of CO depend on the concentration and length of exposure, as well as each individual's health condition. Most people will not experience any symptoms from prolonged exposure to CO levels of approximately 1 to 70 ppm, but some heart patients might experience an increase in chest pain.
As CO levels increase and remain above 70 ppm, symptoms become more noticeable and can include headache, fatigue and nausea. At sustained CO concentrations above 150 to 200 ppm, disorientation, unconsciousness and death are possible.


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Guest Essay: The difference between them
There is no doubt that George Washington and Thomas Jefferson were slave owners. There is no avoiding their complicity in America's original sin. What makes them different from Robert E. Lee and Stonewall Jackson is that Washington and Jefferson labored militarily and legislatively to establish the United States. True, slavery and white supremacy were built into the foundation of life in this country. However, Lee and Jackson and their confederate cohorts fought to destroy the union that Washington and Jefferson worked so hard to establish.
Robert E. Lee violated his oath as a West Point trained military officer to defend the United States "against all enemies foreign and domestic." By preferring his status as a Virginian over his status as an American he engaged in treason in his attempt to overthrow the US government. Let's remember that as people fight so hard to maintain the confederate monuments located in places all around this country.
MORE: McMickle: Trump creates climate for hatred to grow
There is no statue to any British general who fought against this country between 1776-1781. There are no statues to German or Japanese generals who fought against the US in World War II. If we do not honor defeated British generals who fought against the establishment of this country, why do we still maintain monuments and statues in honor of generals who fought to destroy the United States of America?
It is sad that Donald Trump, who seems completely devoid of history, cannot make this distinction between our nation's founders and the traitors who fought to destroy our "more perfect union."
Marvin A. McMickle is president and professor of Church Leadership at Colgate Rochester Crozer Divinity School


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Global commodities broker Marex Spectron has just announced that it has appointed Carla Stent as its new Non-Executive Chair of the Group Board.
Carla Stent, until recently Chair of the Audit & Compliance Committee, takes over from Simon Heale, who stood down in December after three years in the role.
Stent's current Board roles include the Post Office Limited, JP Morgan Elect plc, Savernake Capital Group and Power to Change. She has also served on the boards of Change Alliance (India) Private Limited, Christian Aid, The Young Women's Trust, and Virgin Group, amongst others.
Carla Stent commented:
I am delighted to have been appointed Chair of Marex Spectron. This is an exciting time for the company, with a number of recent acquisitions and new developments, and I look forward to closely working with Ian Lowitt and the Board to continue on this upwards trajectory.
Jeremy Isaac's of JRJ Group added:
To have someone of Carla's calibre as Chair of Marex Spectron is a wonderful outcome for the firm. After four years on the Board she has a tremendous understanding of Marex Spectron and brings great experience to this role.
Marex Spectron has recently completed the acquisitions of the Irish energy broker Energy Broking Ireland Limited (EBI), as well as the customer business of Rosenthal Collins Group LLC (RCG).


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Earlier I wrote about Martha Dodd, an American woman who saw with her own eyes what was happening in Germany after 1933 and forcefully warned a disbelieving American public. But before Martha, there was Dorothy Thompson, the first American journalist to be kicked out of Germany by Goebbels. Dorothy made her way as a freelance journalist to Germany in the 1920s; by 1925 she was heading up the Berlin bureau of the New York Post, writing biting commentary which made her so famous that she attracted the attention of Sinclair Lewis, who married her. Thompson became completely fluent in German. In 1931 she was invited to sit down for an interview with Hitler, whom she found comically preposterous. After this "Little Man" (Thompson) seized power in 1933, she wrote about her impressions in a book, I saw Hitler, introducing Hitler to American audiences for the first time. It was this book which so infuriated Goebbels and resulted in her expulsion.
Back in the States, Dorothy Thompson went on the lecture circuit warning a skeptical American audience about the dangers of Nazi Germany; she reached an even wider audience through her regular radio broadcasts. But because she knew the true nature of the Nazi regime, she understood the perils for anti-fascist Germans - particularly writers. It is not an exaggeration to say that Dorothy Thompson is a savior of 20th century German letters. She used her celebrity, her considerable organizational talents, and even her own money to bring as many writers to America as possible.
It was extremely difficult for any European to get into isolationist America in the 1930's: for one thing, emigrants needed an affidavit from an American "sponsor". These were extremely hard to come by, and not a few refugees from the Nazi terror perished in Europe for lack of a sponsor. Dorothy Thompson personally knew many of the key writers in Berlin and Vienna; she sponsored the expressionist playwright Ernst Toller and the Austrian literary salonist Eugenie Schwarzwald (who never made it). In one of the ironies of history, the lifelong Republican Thompson sponsored the Marxist Bertolt Brecht. In the case of Carl Zuckmayer, Thompson flew to Washington DC and stormed into the Oval Office unannounced (impossible today) to have President Roosevelt personally sign an affidavit. Zuckmayer and his family spent their first weeks in New York at Thompson's apartment on Central Park. When she couldn't help personally, she enlisted the aid of others. Peter Kurth, Thompson's biographer, wrote me this: " What she did was make sure that every damn person she knew in the United States sponsored at least one or two people while there was still time, her efforts to bring in hordes of refugees solely on the grounds of "racial persecution" having failed before Congress."
Those writers she couldn't help, such as the great Austrian writers Joseph Roth and Robert Musil, she introduced to American readers with her own translations. Thompson translated and secured American publication of Roth's The Radetzky March and Musil's notoriously difficult The Man without Qualities.
Thompson used her platform to heap scorn on the American admirers of Nazi Germany - of which there were many until America was brought into the war. In 1939 she attended a huge rally of the pro-Nazi German-American Bund at Madison Square Garden, and had to be rescued by police after she stood up and laughed at one of Bund leader Frtiz Kuhn's anti-semitic tirades. Dorothy was not afraid to call Charles Lindbergh - America's darling - a "somber cretin" because of his pro-Nazi sympathies. By 1940, Dorothy Thompson was, next to Eleanor Roosevelt, the most influential woman in America, and she used this influence to keep the Geist of a free Germany alive though the darkest days of the war. Thanks to her, the German exiles suffered only minor consequences during this period : for the most part they were not viewed as "enemy aliens".
After the war she once again came to the defense of her German exile friends, as they were hounded by the FBI during the anti-communist hysteria of the McCarthy period. It would take a book to recount everything that Dorothy Thompson did for Free (anti-fascist) Germany; the literary landscape of postwar Germany would look very bleak indeed had it not been for the intervention of this brave champion of freedom:
"Political freedom is the condition of all freedom, as the people of Russia have learned, as the people of Italy have learned, and as the people of Germany have learned. They gave up political freedom to get something else which they thought at the moment was very much more important, and then they found out that there is not anything more important. And the first condition of political freedom is that we should stick to a regime of law, and not move off the path toward a regime of men."
-Dorothy Thompson