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Content Posted in 2014
3-Dimensional histological reconstruction and imaging of the murine pancreas., Steven L. Ciciotte, Mark Lessard, Ellen C. Akeson, Elizabeth Cameron, Timothy M. Stearns, James M. Denegre, Jesus Ruberte, and Karen L. Svenson
AAV-mediated lysophosphatidylcholine acyltransferase 1 (Lpcat1) gene replacement therapy rescues retinal degeneration in rd11 mice., Xufeng Dai, Juanjuan Han, Yan Qi, Hua Zhang, Lue Xiang, Jineng Lv, Jie Li, Wen-Tao Deng, Bo Chang, William W Hauswirth, and Ji-jing Pang
ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma., Monisha E Nongpiur, Chiea Chuen Khor, Hongyan Jia, Belinda K Cornes, Li-Jia Chen, Chunyan Qiao, K Saidas Nair, Ching-Yu Cheng, Liang Xu, Ronnie George, Do Tan, Khaled Abu-Amero, Shamira A Perera, Mineo Ozaki, Takanori Mizoguchi, Yasuo Kurimoto, Sancy Low, Liza-Sharmini A Tajudin, Ching-Lin Ho, Clement C Y Tham, Ileana Soto, Paul T K Chew, Hon-Tym Wong, Balekudaru Shantha, Masako Kuroda, Essam A Osman, Guangxian Tang, Sujie Fan, Hailin Meng, Hua Wang, Bo Feng, Victor H K Yong, Serena M L Ting, Yang Li, Ya-Xing Wang, Zheng Li, Raghavan Lavanya, Ren-Yi Wu, Ying-Feng Zheng, Daniel H Su, Seng-Chee Loon, R Rand Allingham, Michael A Hauser, Nagaswamy Soumittra, Vedam L Ramprasad, Naushin Waseem, Azhany Yaakub, Kee-Seng Chia, Govindasamy Kumaramanickavel, Tina T Wong, Alicia C How, Tran Nguyen Bich Chau, Cameron P Simmons, Jin-Xin Bei, Yi-Xin Zeng, Shomi S Bhattacharya, Mingzhi Zhang, Donald T Tan, Yik-Ying Teo, Saleh A Al-Obeidan, Do Nhu Hon, E-Shyong Tai, Seang-Mei Saw, Paul J Foster, Lingam Vijaya, Jost B Jonas, Tien-Yin Wong, Simon W M John, Chi-Pui Pang, Eranga N Vithana, Ningli Wang, and Tin Aung
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males., David E. Harrison, Randy Strong, David B Allison, Bruce N Ames, Clinton M. Astle, Hani Atamna, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Nancy L Nadon, James F Nelson, Scott Pletcher, James W Simpkins, Daniel Smith, J Erby Wilkinson, and Richard A Miller
A Common Functional Regulatory Variant at a Type 2 Diabetes Locus Upregulates ARAP1 Expression in the Pancreatic Beta Cell., Jennifer R Kulzer, Michael L. Stitzel, Mario A Morken, Jeroen R Huyghe, Christian Fuchsberger, Johanna Kuusisto, Markku Laakso, Michael Boehnke, Francis S Collins, and Karen L Mohlke
A Dominant Mutation in Hexokinase 1 (HK1) Causes Retinitis Pigmentosa., Lori S Sullivan, Daniel C Koboldt, Sara J Bowne, Steven Lang, Susan H Blanton, Elizabeth Cadena, Cheryl E Avery, Richard A Lewis, Kaylie Webb-Jones, Dianna H Wheaton, David G Birch, Razck Coussa, Huanan Ren, Irma Lopez, Christina Chakarova, Robert K Koenekoop, Charles A Garcia, Robert S Fulton, Richard K Wilson, George M. Weinstock, and Stephen P Daiger
A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation., Sally H Cross, Danilo G Macalinao, Lisa McKie, Lorraine Rose, Alison L Kearney, Joe Rainger, Caroline Thaung, Margaret Keighren, Shalini Jadeja, Katrine West, Stephen C. Kneeland, Richard S. Smith, Gareth R. Howell, Fiona Young, Morag Robertson, Rob van T' Hof, Simon WM John, and Ian J Jackson
A genetic interaction network model of a complex neurological disease., Anna L. Tyler, Tracy C. McGarr, Barbara Beyer, Wayne N. Frankel, and Gregory W. Carter
A lack of immune system genes causes loss in high frequency hearing but does not disrupt cochlear synapse maturation in mice., Melissa A Calton, Dasom Lee, Srividya Sundaresan, Diana Mendus, Rose Leu, Felix Wangsawihardja, Kenneth R. Johnson, and Mirna Mustapha
Alopecia areata: updates from the mouse perspective., John P. Sundberg, Annerose Berndt, Kathleen A. Silva, Victoria E. Kennedy, Beth A. Sundberg, Helen B Everts, Robert H Rice, and Lloyd E King
Alterations in thin filament length during postnatal skeletal muscle development and aging in mice., David S Gokhin, Emily A Dubuc, Kendra Q Lian, Luanne L. Peters, and Velia M Fowler
Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice., C Gonzales, M M Zaleska, D R Riddell, K P Atchison, A Robshaw, H Zhou, and S J Sukoff Rizzo
Alternative RNA isoform analysis in Adad1tm1Reb mutant testes., He Yang
A major QTL on mouse chromosome 17 resulting in lifespan variability in SOD1-G93A transgenic mouse models of amyotrophic lateral sclerosis., Roger B Sher, Terry D Heiman-Patterson, Elizabeth A Blankenhorn, Juliann Jiang, Guillermo Alexander, Jeffrey S Deitch, and Gregory A. Cox
A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse., Abdul Salam Jarrah, Filippo Castiglione, Nicholas P Evans, Robert W Grange, and Reinhard Laubenbacher
A method for increasing expressivity of Gene Ontology annotations using a compositional approach., Rachael P Huntley, Midori A Harris, Yasmin Alam-Faruque, Judith A. Blake, Seth Carbon, Heiko Dietze, Emily C Dimmer, Rebecca E Foulger, David P. Hill, Varsha K Khodiyar, Antonia Lock, Jane Lomax, Ruth C Lovering, Prudence Mutowo-Meullenet, Tony Sawford, Kimberly Van Auken, Valerie Wood, and Christopher J Mungall
A methods paper that led to much more., Derry C. Roopenian
A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trimers., Ron Korstanje, Christina R Caputo, Rosalinda A. Doty, Susan A. Cook, Roderick T Bronson, Muriel T. Davisson, and Jeffrey H Miner
A murine rp1 missense mutation causes protein mislocalization and slowly progressive photoreceptor degeneration., Delu Song, Steve Grieco, Yafeng Li, Allan Hunter, Sally Chu, Liangliang Zhao, Ying Song, Robert A DeAngelis, Lan-Ying Shi, Qin Liu, Eric A Pierce, Patsy M. Nishina, John D Lambris, and Joshua L Dunaief
An algebra-based method for inferring gene regulatory networks., Paola Vera-Licona, Abdul Jarrah, Luis David Garcia-Puente, John McGee, and Reinhard Laubenbacher
Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division., Alexej Abyzov, Rebecca Iskow, Omer Gokcumen, David W Radke, Suganthi Balasubramanian, Baikang Pei, Lukas Habegger, Genomes Project Consortium, Charles Lee, and Mark Gerstein
Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components., Papia Chakraborty, F William Buaas, Manju Sharma, Benjamin E Smith, Anne R Greenlee, Stephen M Eacker, and Robert E. Braun
An ENU-induced mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility., Yasuhiro Fujiwara, Hirokazu Matsumoto, Kouyou Akiyama, Anuj Srivastava, Mizuho Chikushi, Mary Ann Handel, and Tetsuo Kunieda
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia., Birgit Knoechel, Justine E Roderick, Kaylyn E Williamson, Jiang Zhu, Jens G Lohr, Matthew J Cotton, Shawn M Gillespie, Daniel Fernandez, Manching Ku, Hongfang Wang, Federica Piccioni, Serena J Silver, Mohit Jain, Daniel Pearson, Michael J Kluk, Christopher J Ott, Leonard D. Shultz, Michael A Brehm, Dale L Greiner, Alejandro Gutierrez, Kimberly Stegmaier, Andrew L Kung, David E Root, James E Bradner, Jon C Aster, Michelle A Kelliher, and Bradley E Bernstein
Animal models of exfoliation syndrome, now and future., Simon W M John, Jeffrey M. Harder, John H Fingert, and Michael G Anderson
Antiepileptic activity of preferential inhibitors of persistent sodium current., Lyndsey L Anderson, Christopher H Thompson, Nicole A Hawkins, Ravi D Nath, Adam A Petersohn, Sridharan Rajamani, William S Bush, Wayne N. Frankel, Carlos G Vanoye, Jennifer A Kearney, and Alfred L George
Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models., Mallika Singh, Suzana S Couto, William F Forrest, Anthony Lima, Jason H Cheng, Rafael Molina, Jason E Long, Patricia Hamilton, Angela McNutt, Ian Kasman, Michelle A Nannini, Hani Bou Reslan, Tim C Cao, Calvin C K Ho, Kai H Barck, Richard A D Carano, Oded Foreman, Jeffrey Eastham-Anderson, Adrian M Jubb, Napoleone Ferrara, and Leisa Johnson
Applying "gold standards" to in-vitro-derived germ cells., Mary Ann Handel, John J. Eppig, and John C Schimenti
A promoter-level mammalian expression atlas., FANTOM Consortium and Judith A. Blake
A single-nucleotide polymorphism in the Abcc6 gene associates with connective tissue mineralization in mice similar to targeted models for pseudoxanthoma elasticum., Annerose Berndt, Qiaoli Li, Christopher S. Potter, Yanhua Liang, Kathleen A. Silva, Victoria E. Kennedy, Jouni Uitto, and John P. Sundberg
A topological similarity measure for proteins., Gabriell Máté, Andreas Hofmann, Nicolas Wenzel, and Dieter W Heermann
B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells., Jun Sik Lee, Lisa Scandiuzzi, Anjana Ray, Joyce Wei, Kimberly A Hofmeyer, Yael M Abadi, P'ng Loke, Juan Lin, Jianda Yuan, David V. Serreze, James P Allison, and Xingxing Zang
Basis for enhanced barrier function of pigmented skin., Mao-Qiang Man, Tzu-Kai Lin, Juan L Santiago, Anna Celli, Lily Zhong, Zhi-Ming Huang, Truus Roelandt, Melanie Hupe, John P. Sundberg, Kathleen A. Silva, Debra Crumrine, Gemma Martin-Ezquerra, Carles Trullas, Richard Sun, Joan S Wakefield, Maria L Wei, Kenneth R Feingold, Theodora M Mauro, and Peter M Elias
Basis of synaptic dysfunction related to Charcot-Marie-Tooth type 2D: investigating active zones., Lauren Budd
B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity., Jason Qian, Qiao Wang, Marei Dose, Nathanael Pruett, Kyong-Rim Kieffer-Kwon, Wolfgang Resch, Genqing Liang, Zhonghui Tang, Ewy Mathé, Christopher Benner, Wendy Dubois, Steevenson Nelson, Laura Vian, Thiago Y Oliveira, Mila Jankovic, Ofir Hakim, Anna Gazumyan, Rushad Pavri, Parirokh Awasthi, Bin Song, Geng Liu, Longyun Chen, Shida Zhu, Lionel Feigenbaum, Louis Staudt, Cornelis Murre, Yijun Ruan, Davide F Robbiani, Qiang Pan-Hammarström, Michel C Nussenzweig, and Rafael Casellas
Behavioral aging in diversity outbred mice: disparate phenotypes of inbred and heterogeneous populations, Casey Acklin
Biomarkers and molecular imaging in gastrointestinal cancers., Wa Xian, Frank D. McKeon, and Khek Yu Ho
Brazilian quilombos: A repository of Amerindian alleles., Carolina Carvalho Gontijo, Carlos Eduardo Guerra Amorim, Neide Maria Oliveira Godinho, Rafaela Cesare Parmezan Toledo, Adriana Nunes, Wellington Silva, Maria Manuela Da Fonseca Moura, José Carlos Coutinho De Oliveira, Rubiani C Pagotto, Maria De Nazaré Klautau-Guimarães, and Silviene Fabiana De Oliveira
C57BL/6J congenic Prp-TDP43A315T mice develop progressive neurodegeneration in the myenteric plexus of the colon without exhibiting key features of ALS., Theo Hatzipetros, Laurent P. Bogdanik, Valerie R Tassinari, Joshua D Kidd, Andy J Moreno, Crystal Davis, Melissa Osborne, Andrew Austin, Fernando G Vieira, Cathleen Lutz, and Steve Perrin
C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response., Vivek Kumar, Kyungin Kim, Chryshanthi Joseph, Saïd Kourrich, Seung-Hee Yoo, Hung Chung Huang, Martha H Vitaterna, Fernando Pardo-Manuel de Villena, Gary Churchill, Antonello Bonci, and Joseph S Takahashi
CbGRiTS: Cerebellar gene regulation in time and space., Thomas Ha, Douglas Swanson, Matt Larouche, Randy Glenn, Dave Weeden, Peter Zhang, Kristin Hamre, Michael Langston, Charles Phillips, Mingzhou Song, Zhengyu Ouyang, Elissa J. Chesler, Suman Duvvurru, Roumyana Yordanova, Yan Cui, Kate Campbell, Greg Ricker, Carey Phillips, Ramin Homayouni, and Dan Goldowitz
CcpA Is Important for Growth and Virulence of Enterococcus faecium., Sudha R Somarajan, Jung H Roh, Kavindra V Singh, George M. Weinstock, and Barbara E Murray
Characterization of a spontaneous retinal neovascular mouse model., Eiichi Hasegawa, Harry Sweigard, Deeba Husain, Ana M Olivares, Bo Chang, Kaylee E Smith, Amy E Birsner, Robert J D'Amato, Norman A Michaud, Yinan Han, Demetrios G Vavvas, Joan W Miller, Neena B Haider, and Kip M Connor
Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli., Matthew D Johnson, James Bell, Kim Clarke, Rachel Chandler, Prachi Pathak, Yandong Xia, Robert L Marshall, George M. Weinstock, Nicholas J Loman, Peter J Winn, and Peter A Lund
Choline kinase beta is required for normal endochondral bone formation., Zhuo Li, Gengshu Wu, Roger B Sher, Zohreh Khavandgar, Martin Hermansson, Gregory A. Cox, Michael R Doschak, Monzur Murshed, Frank Beier, and Dennis E Vance
Chromatin connectivity maps reveal dynamic promoter-enhancer long-range associations., Yubo Zhang, Chee-Hong Wong, Ramon Y Birnbaum, Guoliang Li, Rebecca Favaro, Chew Yee Ngan, Joanne Lim, Eunice Tai, Huay Mei Poh, Eleanor Wong, Fabianus Hendriyan Mulawadi, Wing-Kin Sung, Silvia Nicolis, Nadav Ahituv, Yijun Ruan, and Chia-Lin Wei
Chronic Proliferative Dermatitis in Sharpin Null Mice: Development of an Autoinflammatory Disease in the Absence of B and T Lymphocytes and IL4/IL13 Signaling., Christopher S. Potter, Zhe Wang, Kathleen A. Silva, Victoria E. Kennedy, Timothy M. Stearns, Lisa Burzenski, Leonard D. Shultz, Harm Hogenesch, and John O. Sundberg
CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI., Felipe T Salles, Leonardo R Andrade, Soichi Tanda, M'hamed Grati, Kathleen L Plona, Leona H. Gagnon, Kenneth R. Johnson, Bechara Kachar, and Mark A Berryman
Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation., Jessica S Blackburn, Sali Liu, Jayme L Wilder, Kimberly P Dobrinski, Riadh Lobbardi, Finola E Moore, Sarah A Martinez, Eleanor Y Chen, Charles Lee, and David M Langenau
Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease., Harriet M. Jackson, Ileana Soto, Leah C. Graham, Gregory W. Carter, and Gareth R. Howell
c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells., Justine E Roderick, Jessica Tesell, Leonard D. Shultz, Michael A Brehm, Dale L Greiner, Marian H Harris, Lewis B Silverman, Stephen E Sallan, Alejandro Gutierrez, A Thomas Look, Jun Qi, James E Bradner, and Michelle A Kelliher
Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma., Gareth R. Howell, Katharine H MacNicoll, Catherine E. Braine, Ileana Soto, Danilo G Macalinao, Gregory L Sousa, and Simon W M John
Comparison of inference reliability of ovarian cancer purity., Jared Graveley
Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses., Deanna Lamont, Gayatri Mukherjee, P Rajesh Kumar, Dibyendu Samanta, Caroline G. McPhee, Thomas W H Kay, Steven C Almo, Teresa P DiLorenzo, and David V. Serreze
Complex Traits., Wayne N. Frankel
Correction of the Crb1rd8 Allele and Retinal Phenotype in C57BL/6N Mice Via TALEN-Mediated Homology-Directed Repair., Benjamin E. Low, Mark P. Krebs, J Keith Joung, Shengdar Q Tsai, Patsy M. Nishina, and Michael V. Wiles
Crisp1 and alopecia areata in C3H/HeJ mice., John P. Sundberg, Alexander Awgulewitsch, Nathan D Pruett, Christopher S Potter, Kathleen A Silva, Timothy M Stearns, Beth A. Sundberg, Mariana Weigel Muñoz, Patricia S Cuasnicu, Lloyd E King, and Robert H Rice
Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements., Tsuyoshi Inoue, Takahide Kohro, Toshiya Tanaka, Yasuharu Kanki, Guoliang Li, Huay-Mei Poh, Imari Mimura, Mika Kobayashi, Akashi Taguchi, Takashi Maejima, Jun-Ichi Suehiro, Akira Sugiyama, Kiyomi Kaneki, Hirofumi Aruga, Shoulian Dong, Junko F Stevens, Shogo Yamamoto, Shuichi Tsutsumi, Toshiro Fujita, Xiaoan Ruan, Hiroyuki Aburatani, Masaomi Nangaku, Yijun Ruan, Tatsuhiko Kodama, and Youichiro Wada
Cryptic and complex chromosomal aberrations in early-onset neuropsychiatric disorders., Harrison Brand, Vamsee Pillalamarri, Ryan L Collins, Stacey Eggert, Colm O'Dushlaine, Ellen B Braaten, Matthew R Stone, Kimberly Chambert, Nathan D Doty, Carrie Hanscom, Jill A Rosenfeld, Hillary Ditmars, Jessica Blais, Ryan Mills, Charles Lee, James F Gusella, Steven McCarroll, Jordan W Smoller, Michael E Talkowski, and Alysa E Doyle
DBA/2J Mice Are Susceptible to Diabetic Nephropathy and Diabetic Exacerbation of IOP Elevation., Ileana Soto, Gareth R. Howell, Cai W John, Joseph L Kief, Richard T Libby, and Simon W M John
Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy., Ye Liu, Jakob S Satz, My-Nuong Vo, Leslie A Nangle, Paul Schimmel, and Susan L. Ackerman
Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load., Yves Lévy, Rodolphe Thiébaut, Monica Montes, Christine Lacabaratz, Louis Sloan, Bryan King, Sophie Pérusat, Carson Harrod, Amanda Cobb, Lee K Roberts, Mathieu Surenaud, Céline Boucherie, Sandra Zurawski, Constance Delaugerre, Laura Richert, Geneviève Chêne, Jacques Banchereau, and Karolina Palucka
Dendritic spine density changes: a correlation with age and behavioral phenotypes., Courtney Vaughn
Derivation and characterization of mouse embryonic stem cells from permissive and nonpermissive strains., Anne Czechanski, Candice Byers, Ian Greenstein, Nadine Schrode, Leah Rae Donahue, Anna-Katerina Hadjantonakis, and Laura G Reinholdt
Design, construction and evaluation of a LEGO Skinner box for educational use., Andrew Gallup
Detecting and characterizing pleiotropy: new methods for uncovering the connection between the complexity of genomic architecture and multiple phenotypes- session introduction., Anna L. Tyler, Dana C Crawford, and Sarah A Pendergrass
Detection of chromosomal breakpoints in patients with developmental delay and speech disorders., Kagistia H Utami, Axel M Hillmer, Irene Aksoy, Elaine G Y Chew, Audrey S M Teo, Zhenshui Zhang, Charlie W H Lee, Pauline J Chen, Chan Chee Seng, Pramila N Ariyaratne, Sigrid L Rouam, Lim Seong Soo, Saira Yousoof, Ivan Prokudin, Gregory Peters, Felicity Collins, Meredith Wilson, Alyson Kakakios, Georges Haddad, Arnaud Menuet, Olivier Perche, Stacey Kiat Hong Tay, Ken W K Sung, Xiaoan Ruan, Yijun Ruan, Edison Liu, Sylvain Briault, Robyn V Jamieson, Sonia Davila, and Valere Cacheux
Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice., K Saidas Nair, Jessica Barbay, Richard Smith, Sharmila Masli, and Simon W M John
Developmental genotyping and phenotyping of a novel mouse mutant, Olivia Katz
Development and function of human innate immune cells in a humanized mouse model., Anthony Rongvaux, Tim Willinger, Jan Martinek, Till Strowig, Sofia V Gearty, Lino L Teichmann, Yasuyuki Saito, Florentina Marches, Stephanie Halene, A Karolina Palucka, Markus G Manz, and Richard A Flavell
Development of a human macrophage migration inhibitory factor transgenic NSG mouse model to enhance engraftment of primary human chronic lymphocytic leukemia., Olive Baranowski
Development of an optimized ex-vivo organotypic slice culture systems for cancer studies, and a study of the molecular mechanism of Nothch1 in stem cell maintenance and cellular transformation., Efrat Bentolila
DFLAT: functional annotation for human development., Heather C Wick, Harold J. Drabkin, Huy Ngu, Michael Sackman, Craig Fournier, Jessica Haggett, Judith A. Blake, Diana W Bianchi, and Donna K Slonim
Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children., Raquel G Cao, Nicolas M Suarez, Gerlinde Obermoser, Santiago M C Lopez, Emilio Flano, Sara E Mertz, Randy A Albrecht, Adolfo García-Sastre, Asuncion Mejias, Hui Xu, Huanying Qin, Derek Blankenship, Karolina Palucka, Virginia Pascual, and Octavio Ramilo
Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation., Hiromasa Morikawa, Naganari Ohkura, Alexis Vandenbon, Masayoshi Itoh, Sayaka Nagao-Sato, Hideya Kawaji, Timo Lassmann, Piero Carninci, Yoshihide Hayashizaki, Alistair R R Forrest, Daron M Standley, Hiroshi Date, Shimon Sakaguchi, and FANTOM Consortium
Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells., Takashi Maejima, Tsuyoshi Inoue, Yasuharu Kanki, Takahide Kohro, Guoliang Li, Yoshihiro Ohta, Hiroshi Kimura, Mika Kobayashi, Akashi Taguchi, Shuichi Tsutsumi, Hiroko Iwanari, Shogo Yamamoto, Hirofumi Aruga, Shoulian Dong, Junko F Stevens, Huay Mei Poh, Kazuki Yamamoto, Takeshi Kawamura, Imari Mimura, Jun-Ichi Suehiro, Akira Sugiyama, Kiyomi Kaneki, Haruki Shibata, Yasunobu Yoshinaka, Takeshi Doi, Akimune Asanuma, Sohei Tanabe, Toshiya Tanaka, Takashi Minami, Takao Hamakubo, Juro Sakai, Naohito Nozaki, Hiroyuki Aburatani, Masaomi Nangaku, Xiaoan Ruan, Hideyuki Tanabe, Yijun Ruan, Sigeo Ihara, Akira Endo, Tatsuhiko Kodama, and Youichiro Wada
Discovering pancreatic islet function in an obese mouse model., Chelse-Amoy Steele
Discovery of transgene insertion sites by high throughput sequencing of mate pair libraries., Anuj Srivastava, Vivek M. Philip, Ian Greenstein, Lucy B. Rowe, Mary Barter, Cathleen Lutz, and Laura G Reinholdt
Dissecting the chromatin interactome of microRNA genes., Dijun Chen, Liang-Yu Fu, Zhao Zhang, Guoliang Li, Hang Zhang, Li Jiang, Andrew P Harrison, Hugh P Shanahan, Christian Klukas, Hong-Yu Zhang, Yijun Ruan, Ling-Ling Chen, and Ming Chen
Dissection of complex gene expression using the combined analysis of pleiotropy and epistasis., Vivek M. Philip, Anna L. Tyler, and Gregory W. Carter
Dissection of Immune Gene Networks in Primary Melanoma Tumors Critical for Antitumor Surveillance of Patients with Stage II-III Resectable Disease., Shanthi Sivendran, Rui Chang, Lisa Pham, Robert G Phelps, Sara T Harcharik, Lawrence D Hall, Sebastian G Bernardo, Marina M Moskalenko, Meera Sivendran, Yichun Fu, Ellen H de Moll, Michael Pan, Jee Young Moon, Sonali Arora, Ariella Cohain, Analisa DiFeo, Tammie C Ferringer, Mikhail Tismenetsky, Cindy L Tsui, Philip A Friedlander, Michael K Parides, Jacques Banchereau, Damien Chaussabel, Mark G Lebwohl, Jedd D Wolchok, Nina Bhardwaj, Steven J Burakoff, William K Oh, Karolina Palucka, Miriam Merad, Eric E Schadt, and Yvonne M Saenger
Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies., Kine Marita Knudsen Sand, Bjørn Dalhus, Gregory J. Christianson, Malin Bern, Stian Foss, Jason Cameron, Darrell Sleep, Magnar Bjørås, Derry C. Roopenian, Inger Sandlie, and Jan Terje Andersen
Dissection of tumor heterogeneity by the proteotoxic stress response., Xiaochen Sun
DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury., Kimberly A Fernandes, Jeffrey M Harder, Simon W M John, Peter Shrager, and Richard T Libby
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos., Daniel M Messerschmidt, Barbara B. Knowles, and Davor Solter
Effects of housing density in five inbred strains of mice., Judy Morgan, Karen L. Svenson, Jeffrey P Lake, Weidong Zhang, Timothy M. Stearns, Michael A. Marion, Luanne L. Peters, Beverly J. Paigen, and Leah Rae Donahue
Electrical stimulation as an alternative method to terminal sperm freeze., Robert Rounds
Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice., Jinhee Lee, Michael A Brehm, Dale Greiner, Leonard D. Shultz, and Hardy Kornfeld
Epigenetic States of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity., Kin-Hoe Chow, Dong-Mi Shin, Molly H Jenkins, Emily E Miller, David J Shih, Seungbum Choi, Benjamin E. Low, Vivek M. Philip, Brad Rybinski, Roderick T Bronson, Michael D Taylor, and Kyuson Yun
Evaluation of cancer immunity in mice., Mary L Disis and Karolina Palucka
Evaluation of semantic similarity measures as search tools in the Gene Ontology and Mammalian Phenotype Ontology., Daniel Galvez
Examination of insulin signaling in an Alms1 gene trap mouse model for Alstrom syndrome., Charles Thorpe
Exome-Based Mapping and Variant Prioritization for Inherited Mendelian Disorders., Daniel C Koboldt, David E Larson, Lori S Sullivan, Sara J Bowne, Karyn M Steinberg, Jennifer D Churchill, Aimee C Buhr, Nathan Nutter, Eric A Pierce, Susan H Blanton, George M. Weinstock, Richard K Wilson, and Stephen P Daiger
Expression of mammalian U2 snRNA genes., Parixit B. Joshi
Expression of Neonatal Fc Receptor in the eye., Michael B Powner, Jenny A G McKenzie, Gregory J. Christianson, Derry C. Roopenian, and Marcus Fruttiger
Familial Alström syndrome: a rare cause of bilateral progressive hearing loss., Fayez Bahmad Jr, Carolina Sousa Alves Costa, Marina Santos Teixeira, Jairo de Barros Filho, Lucas Moura Viana, and Jan D. Marshall
Finding potential new candidate genes for the negative and cognitive symptoms of schizophrenia using mouse phenomics and bioinformatics., Gwenaelle Thomas
Gene Profiling of Postnatal Mfrprd6 Mutant Eyes Reveals Differential Accumulation of Prss56, Visual Cycle and Phototransduction mRNAs., Ramani Soundararajan, Jungyeon Won, Timothy M. Stearns, Jeremy R. Charette, Wanda L. Hicks, Gayle B. Collin, Juergen K. Naggert, Mark P. Krebs, and Patsy M. Nishina
Generation of improved humanized mouse models for human infectious diseases., Michael A Brehm, Michael V. Wiles, Dale L Greiner, and Leonard D. Shultz
Genetically engineered humanized mouse models for preclinical antibody studies., Gabriele Proetzel, Michael V. Wiles, and Derry C. Roopenian
Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice., Gerda A Noordmans, Yuan Huang, Holly S. Savage, Marcory C R F van Dijk, Gert Schaart, Marius A van den Bergh Weerman, Peter Heeringa, Jan-Luuk Hillebrands, Ron Korstanje, and Harry van Goor
Genetic Analysis of Tissue Glutathione Concentrations and Redox Balance., Yang Zhou, David E. Harrison, Kimberly Love-Myers, Yi Chen, Arthur Grider, Kathie Wickwire, John R Burgess, Mateusz A Stochelski, and Robert Pazdro
Genetic modulation of nephrocalcinosis in mouse models of ectopic mineralization: the Abcc6(tm1Jfk) and Enpp1(asj) mutant mice., Qiaoli Li, David W Chou, Thea P Price, John P. Sundberg, and Jouni Uitto
Genome assembly and haplotyping with Hi-C., Jan O Korbel and Charles Lee
Genomic analysis of transcription regulation in drosophila., Jacqueline Duhl
Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver., Catherine Emmanuel, Yoke-Eng Chiew, Joshy George, Dariush Etemadmoghadam, Michael S Anglesio, Raghwa Sharma, Peter Russell, Catherine Kennedy, Sian Fereday, Jillian Hung, Laura Galletta, Russell Hogg, Gerard V Wain, Alison Brand, Rosemary Balleine, Laura MacConaill, Emanuele Palescandolo, Sally M Hunter, Ian Campbell, Alexander Dobrovic, Stephen Q Wong, Hongdo Do, Christine L Clarke, Paul R Harnett, David D L Bowtell, and Anna deFazio
Genomic DNA sequencing of p53 in normal oviduct, tubal tumor, and high grade serous ovarian cancer., Sophie de Bruijn
Genomic encyclopedia of bacteria and archaea: sequencing a myriad of type strains., Nikos C Kyrpides, Philip Hugenholtz, Jonathan A Eisen, Tanja Woyke, Markus Göker, Charles T Parker, Rudolf Amann, Brian J Beck, Patrick S G Chain, Jongsik Chun, Rita R Colwell, Antoine Danchin, Peter Dawyndt, Tom Dedeurwaerdere, Edward F DeLong, John C Detter, Paul De Vos, Timothy J Donohue, Xiu-Zhu Dong, Dusko S Ehrlich, Claire Fraser, Richard Gibbs, Jack Gilbert, Paul Gilna, Frank Oliver Glöckner, Janet K Jansson, Jay D Keasling, Rob Knight, David Labeda, Alla Lapidus, Jung-Sook Lee, Wen-Jun Li, Juncai Ma, Victor Markowitz, Edward R B Moore, Mark Morrison, Folker Meyer, Karen E Nelson, Moriya Ohkuma, Christos A Ouzounis, Norman Pace, Julian Parkhill, Nan Qin, Ramon Rossello-Mora, Johannes Sikorski, David Smith, Mitch Sogin, Rick Stevens, Uli Stingl, Ken-Ichiro Suzuki, Dorothea Taylor, Jim M Tiedje, Brian Tindall, Michael Wagner, George M. Weinstock, Jean Weissenbach, Owen White, Jun Wang, Lixin Zhang, Yu-Guang Zhou, Dawn Field, William B Whitman, George M Garrity, and Hans-Peter Klenk
Genomic Epidemiology of Salmonella enterica Serotype Enteritidis based on Population Structure of Prevalent Lineages., Xiangyu Deng, Prerak T Desai, Henk C den Bakker, Matthew Mikoleit, Beth Tolar, Eija Trees, Rene S Hendriksen, Jonathan G Frye, Steffen Porwollik, Bart C Weimer, Martin Wiedmann, George M. Weinstock, Patricia I Fields, and Michael McClelland
Germline Quality Control: eEF2K Stands Guard to Eliminate Defective Oocytes., Hsueh-Ping Chu, Yi Liao, James S Novak, Zhixian Hu, Jason J Merkin, Yuriy Shymkiv, Bart P Braeckman, Maxim V Dorovkov, Alexandra Nguyen, Peter M Clifford, Robert G Nagele, David E. Harrison, Ronald E Ellis, and Alexey G Ryazanov
GLUT4 Defects in Adipose Tissue Are Early Signs of Metabolic Alterations in Alms1GT/GT, a Mouse Model for Obesity and Insulin Resistance., Francesca Favaretto, Gabriella Milan, Gayle B. Collin, Jan D. Marshall, Fabio Stasi, Pietro Maffei, Roberto Vettor, and Juergen K. Naggert
H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency., Bérénice A Benayoun, Elizabeth A Pollina, Duygu Ucar, Salah Mahmoudi, Kalpana Karra, Edith D Wong, Keerthana Devarajan, Aaron C Daugherty, Anshul B Kundaje, Elena Mancini, Benjamin C Hitz, Rakhi Gupta, Thomas A Rando, Julie C Baker, Michael P Snyder, J Michael Cherry, and Anne Brunet
HCoDES Reveals Chromosomal DNA End Structures with Single-Nucleotide Resolution., Yair Dorsett, Yanjiao Zhou, Anthony T Tubbs, Bo-Ruei Chen, Caitlin Purman, Baeck-Seung Lee, Rosmy George, Andrea L Bredemeyer, Jiang-Yang Zhao, Erica Sodergren Weinstock, George M. Weinstock, Nathan D Han, Alejandro Reyes, Eugene M Oltz, Dale Dorsett, Ziva Misulovin, Jacqueline E Payton, and Barry P Sleckman
Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene., Kenneth R. Johnson, Leona H. Gagnon, Chantal M. Longo-Guess, Belinda S. Harris, and Bo Chang
Hidden in plain sight: spike-wave discharges in mouse inbred strains., Verity A. Letts, Barbara J. Beyer, and Wayne N. Frankel
High-resolution genetic mapping in the diversity outbred mouse population identifies apobec1 as a candidate gene for atherosclerosis., Tangi L Smallwood, Daniel M Gatti, Pamela Quizon, George M. Weinstock, Kuo-Chen Jung, Liyang Zhao, Kunjie Hua, Daniel Pomp, and Brian J Bennett
High-resolution sex-specific linkage maps of the mouse reveal polarized distribution of crossovers in male germline., Eric Yi Liu, Andrew P Morgan, Elissa J. Chesler, Wei Wang, Gary Churchill, and Fernando Pardo-Manuel de Villena
How chromatin looping and nuclear envelope attachment affect genome organization in eukaryotic cell nuclei., Hansjoerg Jerabek and Dieter W Heermann
Human cancer growth and therapy in immunodeficient mouse models., Leonard D. Shultz, Neal Goodwin, Fumihiko Ishikawa, Vishnu Hosur, Bonnie L. Lyons, and Dale L Greiner
Human CD141+ Dendritic Cells Induce CD4+ T Cells To Produce Type 2 Cytokines., Chun I. Yu, Christian Becker, Patrick Metang, Florentina Marches, Yuanyuan Wang, Hori Toshiyuki, Jacques Banchereau, Miriam Merad, and A Karolina Palucka
Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies., Gabriele Proetzel and Derry C. Roopenian
Human plasma cells express granzyme B., Wei Xu, Priya Narayanan, Ning Kang, Sandra Clayton, Yoichiro Ohne, Peiqing Shi, Marie-Cecile Herve, Robert Balderas, Capucine Picard, Jean-Laurent Casanova, Jean-Pierre Gorvel, Sangkon Oh, Virginia Pascual, and Jacques Banchereau
Identification of a QTL in Mus musculus for Alcohol Preference, Withdrawal, and Ap3m2 Expression Using Integrative Functional Genomics and Precision Genetics., Jason A. Bubier, Jeremy Jay, Christopher L. Baker, Susan E Bergeson, Hiroshi Ohno, Pamela Metten, John C Crabbe, and Elissa J. Chesler
Identification of candidate gene regulators linking obesity to sleep., Jasmine Johnson
Identification of clinically relevant read-outs and study of muscle regenerative potential in an improved muscular dystrophy mouse model, the DBA/2J-mdx congenic., Connor Dolan
Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse., Tia DiTommaso, Lynelle K Jones, Denny L Cottle, Anna-Karin Gerdin, Valerie E Vancollie, Fiona M Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P Steel, John P. Sundberg, Jacqueline K White, and Ian M Smyth
Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice., Yuan Huang, Christina R Caputo, Gerda A Noordmans, Saleh Yazdani, Luiz Henrique Monteiro, Jaap van den Born, Harry van Goor, Peter Heeringa, Ron Korstanje, and Jan-Luuk Hillebrands
Identification of the Key Differential Transcriptional Responses of Human Whole Blood Following TLR2 or TLR4 Ligation In-Vitro., Simon Blankley, Christine M Graham, Ashleigh Howes, Chloe I Bloom, Matthew P R Berry, Damien Chaussabel, Virginia Pascual, Jacques Banchereau, Marc Lipman, and Anne O'Garra
Identifying common components across biological network graphs using a bipartite data model., Ej Baker, C Culpepper, C Philips, Jason A. Bubier, M Langston, and Elissa J. Chesler
Identifying differentially expressed genes in sleep deprived mice., Gabriel Vela
Identifying mouse models for skin cancer using the Mouse Tumor Biology Database., Dale A. Begley, Debra M. Krupke, Steven Neuhauser, Joel E Richardson, Paul N Schofield, Carol J. Bult, Janan T. Eppig, and John P. Sundberg
Identifying the gene responsible for a new spontaneous mouse model of neuromuscular disease., Jakub Dziedzic
IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes., Alicia Rodriguez-Pla, Pinakeen Patel, Holden T Maecker, Jose Rossello-Urgell, Nicole Baldwin, Lynda Bennett, Victoria Cantrell, Jeanine Baisch, Marilynn Punaro, Alisa Gotte, Lorien Nassi, Tracey Wright, Anna Karolina Palucka, Jacques Banchereau, and Virginia Pascual
Immune Status, Strain Background, and Anatomic Site of Inoculation Affect Mouse Papillomavirus (MmuPV1) Induction of Exophytic Papillomas or Endophytic Trichoblastomas., John P. Sundberg, Timothy M. Stearns, Joongho Joh, Mary Proctor, Arvind Ingle, Kathleen A. Silva, Soheil S Dadras, A Bennett Jenson, and Shin-Je Ghim
Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development., Ken-Edwin Aryee, Leonard D. Shultz, and Michael A Brehm
Immunohistochemical analysis of metaplastic non-goblet columnar lined oesophagus shows phenotypic similarities to Barrett's oesophagus: A study in an Asian population., Supriya Srivastava, Mei Shan Liew, Frank D. McKeon, Wa Xian, Khay Guan Yeoh, Khek Yu Ho, and Ming Teh
Impaired hypercarbic and hypoxic responses from developmental loss of cerebellar purkinje neurons: implications for sudden infant death syndrome., M Calton, Price E. Dickson, R M Harper, D Goldowitz, and G Mittleman
Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγ(null) mice treated with alogliptin., Agata Jurczyk, Philip Diiorio, Dean Brostowin, Linda Leehy, Chaoxing Yang, Fumihiko Urano, David M Harlan, Leonard D. Shultz, Dale L Greiner, and Rita Bortell
Inductive influence of dystrophin deficiency on rhabdomyosarcoma (RMS) growth in NRG-Dmdmdx-5cv mice: a novel mouse model to evaluate immune therapies., Chantal Barksdale
Inflammatory dilated cardiomyopathy in Abcg5-deficient mice., Dennis W Wilson, Karen L Oslund, Bonnie L. Lyons, Oded Foreman, Lisa Burzenski, Karen L. Svenson, Thomas H Chase, and Leonard D. Shultz
Integrative genetic analysis of allergic inflammation in the murine lung., Samir N P Kelada, Danielle E Carpenter, David L Aylor, Peter Chines, Holly Rutledge, Elissa J. Chesler, Gary A. Churchill, Fernando Pardo-Manuel de Villena, David A Schwartz, and Francis S Collins
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation., Kyong-Rim Kieffer-Kwon, Zhonghui Tang, Ewy Mathe, Jason Qian, Myong-Hee Sung, Guoliang Li, Wolfgang Resch, Songjoon Baek, Nathanael Pruett, Lars Grøntved, Laura Vian, Steevenson Nelson, Hossein Zare, Ofir Hakim, Deepak Reyon, Arito Yamane, Hirotaka Nakahashi, Alexander L Kovalchuk, Jizhong Zou, J Keith Joung, Vittorio Sartorelli, Chia-Lin Wei, Xiaoan Ruan, Gordon L Hager, Yijun Ruan, and Rafael Casellas
Interrogating congenital heart defects with noninvasive fetal echocardiography in a mouse forward genetic screen., Xiaoqin Liu, Richard Francis, Andrew J Kim, Ricardo Ramirez, Guozhen Chen, Ramiah Subramanian, Shane Anderton, Youngsil Kim, Liyin Wong, Judy Morgan, Herbert C. Pratt, Laura G. Reinholdt, William Devine, Linda Leatherbury, Kimimasa Tobita, and Cecilia W Lo
Investigating aspartoacylase activity in mouse podocytes through genomic and proteomic analyses., Yuka Takemon
Investigating neurovascular changes in aging and alzheimer's disease., Jake Radell
Investigating pleiotropic and epistatic effects in the BTBR x C57BL/6 mouse model., Bo Kane
Investigation into the immunogenicity of green fluorescence protein as a tool to eliminate populations of cells in vivo., Isaac Aderinto
In Vivo Detection of Peripherin-Specific Autoreactive B Cells during Type 1 Diabetes Pathogenesis., Nahir Garabatos, Raimon Alvarez, Jorge Carrillo, Jorge Carrascal, Cristina Izquierdo, Harold D. Chapman, Maximiliano Presa, Conchi Mora, David V. Serreze, Joan Verdaguer, and Thomas Stratmann
Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria., Jacky Chung, Sheila A Anderson, Babette Gwynn, Kathryn M Deck, Michael J Chen, Nathaniel B Langer, George C Shaw, Nicholas C Huston, Leah F Boyer, Sumon Datta, Prasad N Paradkar, Liangtao Li, Zong Wei, Amy J Lambert, Kenneth Sahr, Johannes G Wittig, Wen Chen, Wange Lu, Bruno Galy, Thorsten M Schlaeger, Matthias W Hentze, Diane M Ward, Jerry Kaplan, Richard S Eisenstein, Luanne L. Peters, and Barry H Paw
Juxta-articular joint-capsule mineralization in CD73 deficient mice: Similarities to patients with NT5E mutations., Qiaoli Li, Thea P Price, John P. Sundberg, and Jouni Uitto
Lack of neuropathy-related phenotypes in hint1 knockout mice., Kevin L. Seburn, Kathryn H. Morelli, Albena Jordanova, and Robert W. Burgess
Lack of Response to Laser Comb in Spontaneous and Graft-Induced Alopecia Areata in C3H/HeJ Mice., Lloyd E King, Kathleen A. Silva, Victoria E. Kennedy, and John P. Sundberg
Landscape and variation of RNA secondary structure across the human transcriptome., Yue Wan, Kun Qu, Qiangfeng Cliff Zhang, Ryan A Flynn, Ohad Manor, Zhengqing Ouyang, Jiajing Zhang, Robert C Spitale, Michael P Snyder, Eran Segal, and Howard Y Chang
Launch of the new letter category: 'Mouse Mutants with Absent/Minimal Skin Phenotype'., Michael Rendl, John P. Sundberg, John Seykora, Thomas Luger, Ralf Paus, and Thomas Trier-Mork
LIN28A Marks the Spermatogonial Progenitor Population and Regulates Its Cyclic Expansion., Papia Chakraborty, F William Buaas, Manju Sharma, Elizabeth Snyder, Dirk G de Rooij, and Robert E. Braun
Loss of MeCP2 From Forebrain Excitatory Neurons Leads to Cortical Hyperexcitation and Seizures., Wen Zhang, Matthew Peterson, Barbara Beyer, Wayne N. Frankel, and Zhong-Wei Zhang
Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses., Olivier Epaulard, Lucille Adam, Candice Poux, Gerard Zurawski, Nina Salabert, Pierre Rosenbaum, Nathalie Dereuddre-Bosquet, Sandra Zurawski, Anne-Laure Flamar, Sangkon Oh, Gabrielle Romain, Catherine Chapon, Jacques Banchereau, Yves Lévy, Roger Le Grand, and Frédéric Martinon
Meiosis-Specific Cohesin Component, Stag3 Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes., Jessica Hopkins, Grace Hwang, Justin Jacob, Nicklas Sapp, Rick Bedigian, Kazuhiro Oka, Paul Overbeek, Stephen A. Murray, and Philip W Jordan
Metabolomics as a tool for discovery of biomarkers of autism spectrum disorder in the blood plasma of children., Paul R West, David G Amaral, Preeti Bais, Alan M Smith, Laura A Egnash, Mark E Ross, Jessica A Palmer, Burr R Fontaine, Kevin R Conard, Blythe A Corbett, Gabriela G Cezar, Elizabeth L R Donley, and Robert E Burrier
Metagenomic analysis of double-stranded DNA viruses in healthy adults., Kristine M Wylie, Kathie A Mihindukulasuriya, Yanjiao Zhou, Erica Sodergren Weinstock, Gregory A Storch, and George M. Weinstock
Methodology for inferring gene function using phenotype data., Joao A. Ascensao
Microbial sequencing to improve individual and population health., Sharon J Peacock and George M. Weinstock
Misleading results: don't blame the mice., Gary A. Churchill
Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells., Jakob Neef, Sangyong Jung, Aaron B Wong, Kirsten Reuter, Tina Pangrsic, Rituparna Chakrabarti, Sebastian Kügler, Christine Lenz, Régis Nouvian, Rebecca M. Boumil, Wayne N. Frankel, Carolin Wichmann, and Tobias Moser
Molecular dissection of the role of VEGFA in development of Schlemm's canal., Sneha Goswami
Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice., Thomas J. Sproule, Jason A. Bubier, Fiorella C Grandi, Victor Z Sun, Vivek M. Philip, Caroline G. McPhee, Elisabeth B. Adkins, John P. Sundberg, and Derry C. Roopenian
Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics., Mauro Longoni, Frances A High, Meaghan K Russell, Alireza Kashani, Adam A Tracy, Caroline M Coletti, Regis Hila, Ahmed Shamia, Julie Wells, Kate G Ackerman, Jay M Wilson, Carol J. Bult, Charles Lee, Kasper Lage, Barbara R Pober, and Patricia K Donahoe
Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles., James N Sleigh, Robert W. Burgess, Thomas H Gillingwater, and M Zameel Cader
Mouse alopecia areata and heart disease: know your mouse!, John P. Sundberg, Lucie Chevallier, Kathleen A. Silva, Victoria E. Kennedy, Beth A. Sundberg, Qiaoli Li, Jouni Uitto, Lloyd E King, and Annerose Berndt
Mouse modeling of mutational acquisition in human acute myeloid leukemia (AML)., Jennifer Ditano
Mouse models for pseudoxanthoma elasticum: genetic and dietary modulation of the ectopic mineralization phenotypes., Qiaoli Li, Haitao Guo, David W Chou, Annerose Berndt, John P. Sundberg, and Jouni Uitto
Mouse phenome database., Stephen C. Grubb, Carol J. Bult, and Molly A. Bogue
Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility., Chizuru Sogawa, Yasuhiro Fujiwara, Satoshi Tsukamoto, Yuka Ishida, Yukie Yoshii, Takako Furukawa, Tetsuo Kunieda, and Tsuneo Saga
Mutations in Alström protein impair terminal differentiation of cardiomyocytes., Lincoln T Shenje, Peter Andersen, Marc K Halushka, Cecillia Lui, Laviel Fernandez, Gayle B. Collin, Nuria Amat-Alarcon, Wendy Meschino, Ernest Cutz, Kenneth Chang, Raluca Yonescu, Denise A S Batista, Yan Chen, Stephen Chelko, Jane E Crosson, Janet Scheel, Luca Vricella, Brian D Craig, Beth A Marosy, David W Mohr, Kurt N Hetrick, Jane M Romm, Alan F Scott, David Valle, Juergen K. Naggert, Chulan Kwon, Kimberly F Doheny, and Daniel P Judge
Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice., James N Sleigh, Stuart J Grice, Robert W. Burgess, Kevin Talbot, and M Zameel Cader
Next-generation pathogen genomics., George M. Weinstock and Sharon J Peacock
NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : A Model for Stromal Cell-Tumor Cell Interaction for Human Colon Cancer., Justin Maykel, Jian Hua Liu, Hanchen Li, Leonard D. Shultz, Dale L Greiner, and JeanMarie Houghton
Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks., Karen G. Dowell, Allen K. Simons, Hao Bai, Braden Kell, Zack Z Wang, Kyuson Yun, and Matthew A Hibbs
Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication., Irene Guendel, Sergey Iordanskiy, Rachel Van Duyne, Kylene Kehn-Hall, Mohammed Saifuddin, Ravi Das, Elizabeth Jaworski, Gavin C Sampey, Svetlana Senina, Leonard D. Shultz, Aarthi Narayanan, Hao Chen, Benjamin Lepene, Chen Zeng, and Fatah Kashanchi
OMIT: Dynamic, Semi-Automated Ontology Development for the microRNA Domain., Jingshan Huang, Jiangbo Dang, Glen M Borchert, Karen Eilbeck, He Zhang, Min Xiong, Weijian Jiang, Hao Wu, Judith A. Blake, Darren A Natale, and Ming Tan
One more test, Ann Jordan and Interlibrary Loan
On finding bicliques in bipartite graphs: a novel algorithm and its application to the integration of diverse biological data types., Yun Zhang, Charles A Phillips, Gary L Rogers, Erich J Baker, Elissa J. Chesler, and Michael A Langston
Optimizing mouse models of neurodegenerative disorders: are therapeutics in sight?, Cathleen Lutz and Melissa Osborne
OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness., Jerome E Roger, Avinash Hiriyanna, Norimoto Gotoh, Hong Hao, Debbie F Cheng, Rinki Ratnapriya, Marie-Audrey I Kautzmann, Bo Chang, and Anand Swaroop
Out of the bottleneck: the Diversity Outcross and Collaborative Cross mouse populations in behavioral genetics research., Elissa J. Chesler
Patterned progression of bacterial populations in the premature infant gut., Patricio S La Rosa, Barbara B Warner, Yanjiao Zhou, George M. Weinstock, Erica Sodergren Weinstock, Carla M Hall-Moore, Harold J Stevens, William E Bennett, Nurmohammad Shaikh, Laura A Linneman, Julie A Hoffmann, Aaron Hamvas, Elena Deych, Berkley A Shands, William D Shannon, and Phillip I Tarr
Performance of C57BL/6J and DBA/2J mice on a touchscreen-based attentional set-shifting task., Price E. Dickson, Michele A Calton, and Guy Mittleman
Phenotypic and Genotypic Analysis of Clostridium difficile Isolates: a Single-Center Study., Yanjiao Zhou, Carey-Ann D Burnham, Tiffany Hink, Lei Chen, Nurmohammad Shaikh, Aye Wollam, Erica Sodergren Weinstock, George M. Weinstock, Phillip I Tarr, and Erik R Dubberke
Phenotypic Characterization of the KK/HlJ Inbred Mouse Strain., A Berndt, Beth A. Sundberg, Kathleen A. Silva, Victoria E. Kennedy, M A Richardson, Q Li, R T Bronson, J Uitto, and John P. Sundberg
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel Loci in the genetic regulation of bone mass attainment., John P Kemp, Carolina Medina-Gomez, Karol Estrada, Beate St Pourcain, Denise H M Heppe, Nicole M Warrington, Ling Oei, Susan M Ring, Claudia J Kruithof, Nicholas J Timpson, Lisa E Wolber, Sjur Reppe, Kaare Gautvik, Elin Grundberg, Bing Ge, Bram van der Eerden, Jeroen van de Peppel, Matthew A. Hibbs, Cheryl L Ackert-Bicknell, Kwangbom Choi, Daniel L Koller, Michael J Econs, Frances M K Williams, Tatiana Foroud, M Carola Zillikens, Claes Ohlsson, Albert Hofman, André G Uitterlinden, George Davey Smith, Vincent W V Jaddoe, Jonathan H Tobias, Fernando Rivadeneira, and David M Evans
Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival., Jonathan A Coleman, Xianjun Zhu, Hidayat R Djajadi, Laurie L Molday, Richard Smith, Richard T Libby, Simon W M John, and Robert S Molday
Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy., M K Oliva, Tracy C. McGarr, Barbara Beyer, E Gazina, D I Kaplan, L Cordeiro, E Thomas, S D Dib-Hajj, S G Waxman, Wayne N. Frankel, and S Petrou
PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration., Christopher L. Baker, Michael Walker, Shimpei Kajita, Petko M. Petkov, and Kenneth Paigen
Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene., Jill M. Recla, Ray F. Robledo, Daniel M. Gatti, Carol J. Bult, Gary A. Churchill, and Elissa J. Chesler
Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis., Baktiar O Karim, Ki-Jong Rhee, Guosheng Liu, Kyuson Yun, and Steven R Brant
Protein Ontology: a controlled structured network of protein entities., Darren A Natale, Cecilia N Arighi, Judith A. Blake, Carol J. Bult, Karen R. Christie, Julie Cowart, Peter D'Eustachio, Alexander D Diehl, Harold J. Drabkin, Olivia Helfer, Hongzhan Huang, Anna Maria Masci, Jia Ren, Natalia V Roberts, Karen Ross, Alan Ruttenberg, Veronica Shamovsky, Barry Smith, Meher Shruti Yerramalla, Jian Zhang, Aisha Aljanahi, Irem Celen, Cynthia Gan, Mengxi Lv, Emily Schuster-Lezell, and Cathy H Wu
QTL mapping of modifiers of junctional epidermolysis bullosa using phenotypically disparate strains B6 and 129X1., Nabig Chaudhry
Quantitative trait loci that modulate trabecular bone's risk of failure during unloading and reloading., Engin Ozcivici, Weidong Zhang, Leah Rae Donahue, and Stefan Judex
Quantitative trait locus mapping methods for diversity outbred mice., Daniel Mario Gatti, Karen L. Svenson, Andrey Shabalin, Long-Yang Wu, William Valdar, Petr Simecek, Neal Goodwin, Riyan Cheng, Daniel Pomp, Abraham Palmer, Elissa J. Chesler, Karl W Broman, and Gary Churchill
Rapamycin Ameliorates Nephropathy despite Elevating Hyperglycemia in a Polygenic Mouse Model of Type 2 Diabetes, NONcNZO10/LtJ., Peter C. Reifsnyder, Rosalinda A. Doty, and David E. Harrison
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction., Richard A Miller, David E. Harrison, Clinton M. Astle, Elizabeth Fernandez, Kevin Flurkey, Melissa Han, Martin A Javors, Xinna Li, Nancy L Nadon, James F Nelson, Scott Pletcher, Adam B Salmon, Zelton Dave Sharp, Sabrina Van Roekel, Lynn Winkleman, and Randy Strong
Rapid identification of major-effect genes using the collaborative cross., Ramesh Ram, Munish Mehta, Lois Balmer, Daniel Mario Gatti, and Grant Morahan
Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells., Hira Lal Goel, Tatiana Gritsko, Bryan Pursell, Cheng Chang, Leonard D. Shultz, Dale L Greiner, Jens Henrik Norum, Rune Toftgard, Leslie M Shaw, and Arthur M Mercurio
Representing kidney development using the gene ontology., Yasmin Alam-Faruque, David P. Hill, Emily C Dimmer, Midori A Harris, Rebecca E Foulger, Susan Tweedie, Helen Attrill, Douglas G Howe, Stephen Randall Thomas, Duncan Davidson, Adrian S Woolf, Judith A. Blake, Christopher J Mungall, Claire O'Donovan, Rolf Apweiler, and Rachael P Huntley
Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection., Te-Chia Wu, Kangling Xu, Romain Banchereau, Florentina Marches, Chun I Yu, Jan Martinek, Esperanza Anguiano, Alexander Pedroza-Gonzalez, G Jackson Snipes, Joyce O'Shaughnessy, Stephen Nishimura, Yong-Jun Liu, Virginia Pascual, Jacques Banchereau, Sangkon Oh, and Karolina Palucka
Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin., Vishnu Hosur, Kenneth R. Johnson, Lisa M. Burzenski, Timothy M Stearns, Richard S. Maser, and Leonard D. Shultz
RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration., Ryuta Ishimura, Gabor Nagy, Ivan Dotu, Huihao Zhou, Xiang-Lei Yang, Paul Schimmel, Satoru Senju, Yasuharu Nishimura, Jeffrey H. Chuang, and Susan L. Ackerman
RNA-Seq Alignment to Individualized Genomes Improves Transcript Abundance Estimates in Multiparent Populations., Steven C. Munger, Narayanan Raghupathy, Kwangbom Choi, Allen K. Simons, Daniel Mario Gatti, Douglas Hinerfeld, Karen L. Svenson, Mark P Keller, Alan D Attie, Matthew A. Hibbs, Joel H. Graber, Elissa J. Chesler, and Gary Churchill
Schlemm's Canal Is a Unique Vessel with a Combination of Blood Vascular and Lymphatic Phenotypes that Forms by a Novel Developmental Process., Krishnakumar Kizhatil, Margaret Ryan, Jeffrey K Marchant, Stephen Henrich, and Simon W M John
Searching for the initiating site of the major capsid protein to generate virus-like particles for a novel laboratory mouse papillomavirus., Joongho Joh, Alfred B Jenson, Arvind Ingle, John P. Sundberg, and Shin-Je Ghim
Selective ablation of the NMDA receptor in somatostatin-positive GABAergic neurons: effects on mouse behavior and neuronal connectivity., Alison Smith
Sepsis from the gut: the enteric habitat of bacteria that cause late-onset neonatal bloodstream infections., Mike A Carl, I Malick Ndao, A Cody Springman, Shannon D Manning, James R Johnson, Brian D Johnston, Carey-Ann D Burnham, Erica Sodergren Weinstock, George M. Weinstock, Todd N Wylie, Makedonka Mitreva, Sahar Abubucker, Yanjiao Zhou, Harold J Stevens, Carla Hall-Moore, Samuel Julian, Nurmohammad Shaikh, Barbara B Warner, and Phillip I Tarr
Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice., Erica B Schleifman, Nicole Ali McNeer, Andrew Jackson, Jennifer Yamtich, Michael A Brehm, Leonard D. Shultz, Dale L Greiner, Priti Kumar, W Mark Saltzman, and Peter M Glazer
SnapShot: Cancer Vaccines., Karolina Palucka and Jacques Banchereau
Spontaneous asj-2J Mutant Mouse as a Model for Generalized Arterial Calcification of Infancy: A Large Deletion/Insertion Mutation in the Enpp1 Gene., Qiaoli Li, C Herbert Pratt, Louise A. Dionne, Heather Fairfield, Son Yong Karst, John P. Sundberg, and Jouni Uitto
Spontaneous CNV in a Novel Mutant Mouse Is Associated With Early VEGF-A-Driven Angiogenesis and Late-Stage Focal Edema, Neural Cell Loss, and Dysfunction., Norihiro Nagai, Pete Lundh von Leithner, Kanako Izumi-Nagai, Brett Hosking, Bo Chang, Ronald E. Hurd, Peter Adamson, Anthony P Adamis, Richard H Foxton, Yin Shan Ng, and David T Shima
Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait., Weiqun Yu, Cheryl L. Ackert-Bicknell, John D Larigakis, Bryce MacIver, William D Steers, Gary Churchill, Warren G Hill, and Mark L Zeidel
Standardized description of scientific evidence using the Evidence Ontology (ECO)., Marcus C Chibucos, Christopher J Mungall, Rama Balakrishnan, Karen R. Christie, Rachael P Huntley, Owen White, Judith A. Blake, Suzanna E Lewis, and Michelle Giglio
STAT3 targets suggest mechanisms of aggressive tumorigenesis in diffuse large B-cell lymphoma., Jennifer Hardee, Zhengqing Ouyang, Yuping Zhang, Anshul Kundaje, Philippe Lacroute, and Michael Snyder
Steady state analysis of Boolean molecular network models via model reduction and computational algebra., Alan Veliz-Cuba, Boris Aguilar, Franziska Hinkelmann, and Reinhard Laubenbacher
Subcapsular transplantation of tissue in the kidney., Leonard D. Shultz, Neal Goodwin, Fumihiko Ishikawa, Vishnu Hosur, Bonnie L. Lyons, and Dale L Greiner
Systems consequences of amplicon formation in human breast cancer., Koichiro Inaki, Francesca Menghi, Xing Yi Woo, Joel P. Wagner, Pierre-Étienne Jacques, Yi Fang Lee, Phung Trang Shreckengast, Wendy WeiJia Soon, Ankit Malhotra, Audrey S M Teo, Axel M Hillmer, Alexis Jiaying Khng, Xiaoan Ruan, Swee Hoe Ong, Denis Bertrand, Niranjan Nagarajan, R Krishna Murthy Karuturi, Alfredo Hidalgo Miranda, and Edison T. Liu
Testing a protective role for angiogenin treatment in embryonic stem cell-derived motor neurons derived from transgenic mice carrying human ALS mutation TDP43 (A315T), Kevin Clare
The altered expression of CELF4 responsive mRNAs in kindled wild-type mice., Bethany Berry
The Antigen Presenting Cells Instruct Plasma Cell Differentiation., Wei Xu and Jacques Banchereau
The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse., Andrew P Morgan, James J Crowley, Randal J Nonneman, Corey R Quackenbush, Cheryl N Miller, Allison K Ryan, Molly A. Bogue, Sur Herrera Paredes, Scott Yourstone, Ian M Carroll, Thomas H Kawula, Maureen A Bower, R Balfour Sartor, and Patrick F Sullivan
The Complex Role of Neuroinflammation in Glaucoma., Ileana Soto and Gareth R. Howell
The conjunctival microbiome in health and trachomatous disease: a case control study., Yanjiao Zhou, Martin J Holland, Pateh Makalo, Hassan Joof, Chrissy H Roberts, David Cw Mabey, Robin L Bailey, Matthew J Burton, George M. Weinstock, and Sarah E Burr
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells., Nathalie Schmitt, Yang Liu, Salah-Eddine Bentebibel, Indira Munagala, Laure Bourdery, K Venuprasad, Jacques Banchereau, and Hideki Ueno
The effect of culling on health and physiology of mouse litters., Beverly Paigen, Michael A Marion, Timothy M. Stearns, James M Harper, and Karen L. Svenson
The effects of histone deacetylase 6 inhibition on a mouse model of Charcot-Marie-Tooth disease type 2D., Opemipo Akerele
The function of Netrin5 in the development of the mouse nervous system., Liam Sigaud
The gene expression database for mouse development (GXD): Putting developmental expression information at your fingertips., Constance M. Smith, Jacqueline H. Finger, James A. Kadin, Joel E. Richardson, and Martin Ringwald
The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data., Sebastian Köhler, Sandra C Doelken, Christopher J Mungall, Sebastian Bauer, Helen V Firth, Isabelle Bailleul-Forestier, Graeme C M Black, Danielle L Brown, Michael Brudno, Jennifer Campbell, David R Fitzpatrick, Janan T. Eppig, Andrew P Jackson, Kathleen Freson, Marta Girdea, Ingo Helbig, Jane A Hurst, Johanna Jähn, Laird G Jackson, Anne M Kelly, David H Ledbetter, Sahar Mansour, Christa L Martin, Celia Moss, Andrew Mumford, Willem H Ouwehand, Soo-Mi Park, Erin Rooney Riggs, Richard H Scott, Sanjay Sisodiya, Steven Van Vooren, Ronald J Wapner, Andrew O M Wilkie, Caroline F Wright, Anneke T Vulto-van Silfhout, Nicole de Leeuw, Bert B A de Vries, Nicole L Washingthon, Cynthia Smith, Monte Westerfield, Paul Schofield, Barbara J Ruef, Georgios V Gkoutos, Melissa Haendel, Damian Smedley, Suzanna E Lewis, and Peter N Robinson
The mouse Gene Expression Database (GXD): 2014 update., Constance M. Smith, Jacqueline H. Finger, Terry F. Hayamizu, Ingeborg J. McCright, Jingxia Xu, Joanne Berghout, Jeff Campbell, Lori E. Corbani, Kim L. Forthofer, Pete J. Frost, Dave Miers, David R. Shaw, Kevin R. Stone, Janan T. Eppig, James A. Kadin, Joel E. Richardson, and Martin Ringwald
The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse., Judith A. Blake, Carol J. Bult, Janan T. Eppig, James A. Kadin, Joel E Richardson, and Mouse Genome Database Group
The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses., Tohru Tezuka, Akane Inoue, Taisuke Hoshi, Scott D Weatherbee, Robert W. Burgess, Ryo Ueta, and Yuji Yamanashi
Theory-of-mind in adolescents and young adults with Alström syndrome., Hans Erik Frölander, Claes Möller, Jan D. Marshall, Annette Sundqvist, Berit Rönnåsen, Lil Falkensson, and Björn Lyxell
The PAX2-null immunophenotype defines multiple lineages with common expression signatures in benign and neoplastic oviductal epithelium., Gang Ning, Jonathan G Bijron, Yusuke Yamamoto, Xia Wang, Brooke E Howitt, Michael Herfs, Eric Yang, Yue Hong, Maxence Cornille, Lingyan Wu, Suchanan Hanamornroongruang, Frank D. McKeon, Christopher P Crum, and Wa Xian
The relationships between environmental bacterial exposure, airway bacterial colonization, and asthma., Avraham Beigelman, George M. Weinstock, and Leonard B Bacharier
The role of complement proteins in cancer., Ruchi Shah
The role of Kdm5d in regulating meiotic recombination., James Boucher
The role of telomere length in meiotic DNA recombination., Isabella Beroutsos
The role of the interleukin-2 receptor {gamma} gene in the development and progression of DBA/2J glaucoma., Ricky Anjorin
The wistar legacy to embryonic stem cell research., Barbara B. Knowles
TMEM14C is required for erythroid mitochondrial heme metabolism., Yvette Y Yien, Ray F. Robledo, Iman J Schultz, Naoko Takahashi-Makise, Babette Gwynn, Daniel E Bauer, Abhishek Dass, Gloria Yi, Liangtao Li, Gordon J Hildick-Smith, Jeffrey D Cooney, Eric L Pierce, Kyla Mohler, Tamara A Dailey, Non Miyata, Paul D Kingsley, Caterina Garone, Shilpa M Hattangadi, Hui Huang, Wen Chen, Ellen M Keenan, Dhvanit I Shah, Thorsten M Schlaeger, Salvatore DiMauro, Stuart H Orkin, Alan B Cantor, James Palis, Carla M Koehler, Harvey F Lodish, Jerry Kaplan, Diane M Ward, Harry A Dailey, John D Phillips, Luanne L. Peters, and Barry H Paw
Transcriptional profiles of bovine in vivo pre-implantation development., Zongliang Jiang, Jiangwen Sun, Hong Dong, Oscar Luo, Xinbao Zheng, Craig Obergfell, Yong Tang, Jinbo Bi, Rachel O'Neill, Yijun Ruan, Jingbo Chen, and Xiuchun Cindy Tian
Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines., Romain Banchereau, Nicole Baldwin, Alma-Martina Cepika, Shruti Athale, Yaming Xue, Chun I Yu, Patrick Metang, Abhilasha Cheruku, Isabelle Berthier, Ingrid Gayet, Yuanyuan Wang, Marina Ohouo, LuAnn Snipes, Hui Xu, Gerlinde Obermoser, Derek Blankenship, Sangkon Oh, Octavio Ramilo, Damien Chaussabel, Jacques Banchereau, Karolina Palucka, and Virginia Pascual
Transcriptome analysis of spontaneous and induced lung tumors in mice using RNA Seq., Janaya Shelly
Transplantable Malignant Melanoma in LT.B6 Congenic Mice Resembling Pigmented Epithelioid Melanocytoma in Humans., Soheil S Dadras, Kathleen A. Silva, Lloyd E King, and John P. Sundberg
Two disease models for congenital glycosylation deficiency., Xingjian Zhang
Ultrasmall integrated 3D micro-supercapacitors solve energy storage for miniature devices., Chuizhou Meng, Jimin Maeng, Simon W M John, and Pedro P. Irazoqui
Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation., Swathi Srivatsa, Srinivas Parthasarathy, Olga Britanova, Ingo Bormuth, Amber-Lee Donahoo, Susan L. Ackerman, Linda J Richards, and Victor Tarabykin
Unification of multi-species vertebrate anatomy ontologies for comparative biology in Uberon., Melissa A Haendel, James P Balhoff, Frederic B Bastian, David C Blackburn, Judith A. Blake, Yvonne Bradford, Aurelie Comte, Wasila M Dahdul, Thomas A Dececchi, Robert E Druzinsky, Terry F. Hayamizu, Nizar Ibrahim, Suzanna E Lewis, Paula M Mabee, Anne Niknejad, Marc Robinson-Rechavi, Paul C Sereno, and Christopher J Mungall
Unraveling genetic modifiers in the gria4 mouse model of absence epilepsy., Wayne N. Frankel, Connie L. Mahaffey, Tracy C. McGarr, Barbara J. Beyer, and Verity A. Letts
Variation and Genetic Control of Gene Expression in Primary Immunocytes across Inbred Mouse Strains., Sara Mostafavi, Adriana Ortiz-Lopez, Molly A. Bogue, Kimie Hattori, Cristina Pop, Daphne Koller, Diane Mathis, Christophe Benoist, David A Blair, Michael L Dustin, Susan A Shinton, Richard R Hardy, Tal Shay, Aviv Regev, Nadia Cohen, Patrick Brennan, Michael Brenner, Francis Kim, Tata Nageswara Rao, Amy Wagers, Tracy Heng, Jeffrey Ericson, Katherine Rothamel, Adriana Ortiz-Lopez, Diane Mathis, Christophe Benoist, Taras Kreslavsky, Anne Fletcher, Kutlu Elpek, Angelique Bellemare-Pelletier, Deepali Malhotra, Shannon Turley, Jennifer Miller, Brian Brown, Miriam Merad, Emmanuel L Gautier, Claudia Jakubzick, Gwendalyn J Randolph, Paul Monach, Adam J Best, Jamie Knell, Ananda Goldrath, Vladimir Jojic, Daphne Koller, David Laidlaw, Jim Collins, Roi Gazit, Derrick J Rossi, Nidhi Malhotra, Katelyn Sylvia, Joonsoo Kang, Natalie A Bezman, Joseph C Sun, Gundula Min-Oo, Charlie C Kim, and Lewis L Lanier
When are results too good to be true?, Gary A. Churchill
Whole-Genome Analyses of Enterococcus faecium Isolates with Diverse Daptomycin MICs., Lorena Diaz, Truc T Tran, Jose M Munita, William R Miller, Sandra Rincon, Lina P Carvajal, Aye Wollam, Jinnethe Reyes, Diana Panesso, Natalia L Rojas, Yousif Shamoo, Barbara E Murray, George M. Weinstock, and Cesar A Arias
Whole-Genome Sequence of the C57L/J Mouse Inbred Strain., Guruprasad Ananda, Yuka Takemon, Douglas Hinerfeld, and Ron Korstanje
Whole Genome Sequence of the Treponema pallidum subsp. endemicum Strain Bosnia A: The Genome Is Related to Yaws Treponemes but Contains Few Loci Similar to Syphilis Treponemes., Barbora Staudová, Michal Strouhal, Marie Zobaníková, Darina Cejková, Lucinda L Fulton, Lei Chen, Lorenzo Giacani, Arturo Centurion-Lara, Sylvia M Bruisten, Erica Sodergren, George M. Weinstock, and David Smajs


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I am selling my Sega Game Gear for money to go to my Gameboy SP fund and I have a question: Do I just plug the travel battery pack in to charge it? Do I flip the switch to on or off for charging? Because after all last night I charged it and the battery seems dead. Just want to make sure so I can change my auction on Ebay.
By the way , I took my super nintendo and 12 games to Gamestop over the weekend and got $45 credit. Too bad they have not had an SP in stock in 3 weeks

subset: commoncrawl


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CannaEase™ Skin Protect (For External Application)Regular price Sale price Rs. 649.00
CannaEase™ Skin Protect is a plant-based and chemical free oil that helps manage skin problems. It nourishes, moisturises dry skin, heals skin rash. It is very promising in Lightning scars while boosting supple and soft skin. It is packed with anti-inflammatory properties which helps with psoriasis and eczema.
How Vijaya Leaf Extract affects our body?
The Endocannabinoid system (ECS) is one of the biologic regulatory systems which is responsible for creating and sustaining balance in our body. ECS keeps the body balance or scientifically it maintains homeostasis by monitoring endocannabinoids. The two primary cannabinoid receptors in our body CB1 and CB2, are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues
The Vijaya Leaf Extract contains hundreds of phytocannabinoids among which Cannabidiol and Tetrahydrocannabinol are the most abundant. Cannabidiol plays a larger role in the ECS by modifying how the CB1 and CB2 receptors bind to different cannabinoids. When we have an imbalance in the ECS, supplementing our body with these phytocannabinoids can help our body regain balance.
Benefits of Full-spectrum (Vijaya Leaf Extract) Skin Protect
1. Nourishes and Moisturizes Dry Skin
Reduces dryness and keeps the skin hydrated.
2. Soothes Sensitive Skin
Our full-spectrum extract when mixed with Virgin Coconut oil provides a calming effect to the skin.
3. Boosts Supple and Soft Skin
It can reduce the excess sebum production in the skin, and provides soft and supple skin.
4. Prevents Acne
Virgin Coconut oil with hemp extract is a perfect for acne prone skin It prevents human sebocytes, the cells that create sebum, from producing too much of the oil.
5. Heals Skin Rash
It aids with skin conditions marked by redness, itchiness, and scaly patches.
6. Natural Anti-inflammatory
Cannabidiol is known to have beneficial anti-inflammatory properties, including the ability to reduce the production of inflammatory cells of the immune system called cytokines. Cannabidiol may help those experiencing pain, by reducing pain perception when Cannabidiol interacts with cannabinoid receptors (CB2 receptors).
Vijaya Leaf Extract 1.5%
Virgin Coconut Oil 98.5%
Our product is made with 100% Virgin Coconut Oil and has a tendency to freeze in cold weather (below 18 degrees). If it freezes, please put the Skin Protect Oil in warm water for 10 mins before use.
Apply 10-12 drops gently over the affected area (depending on the size of area of application).
Safety Instructions:
Keep away from Children.
For external use only.
Please discontinue in case you have a reaction to the medicine.
Storage information:
Store in a cool and dry place, away from sunlight.
Key Ingredients:
|Full-spectrum Raw Vijaya leaf extract when mixed with Virgin Coconut oil provides a calming effect to the skin.
|Virgin Coconut oil with hemp extract is a perfect combination for acne prone skin. It prevents human sebocytes, the cells that create sebum, from producing too much of the oil.
We do not recommend the use of our products as an alternative to medical care. Ananta Hempworks Solutions Pvt. Ltd. is not responsible for any individuals reaction to any particular ingredient. We maintain a transparent policy, where each product description on our website includes a complete list of ingredients. People with sensitivities or allergies to any listed ingredient should not use the product. We recommend to always do a patch test to ensure the suitability of the product.
Please do not use any information found within our website to self-diagnose any medical conditions or treat any health-related problems or diseases.
Our products are meant for your personal use and the information provided has been collected from other sources to inform you about the possible benefits of herbs, essential oils, and other natural ingredients used in our products. The content found on this website is for informational purposes only.
All information provided on our website is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any medical condition or disease.
The information provided on our website is not intended to prescribe or be taken as medical advice. Please consult your doctor, should you have any concerns that require medical attention.


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The plan with no funding: Critics attack social care proposal
By Cassie Chambers
Calls for clarity drowned out the government's message on social care today, as the coalition unveiled its much-anticipated white paper.
The white paper, designed to define ways to salvage a social care system "in crisis", included several major changes to the current arrangements.
Yet debate on the content of the bill was overshadowed by arguments over what it is missing: a concrete funding plan.
"Today's proposals are meaningless without the money to make them a reality," shadow health secretary Andy Burnham said.
"The government is failing to face up to England's care crisis."
Many argue that funding decisions are key to the success of social care reform, as an already strained safety net is set to support an increasing number of people in coming years.
According to the Office of National Statistics (ONS), the next two decades will see a 50% increase in the number of 70+ year olds in the UK.
The three main parties tried to come to an agreement on reform before the last general election, but the Tories walked away from negotiations and attacked Labour for proposing a 'death tax'.
The funding proposal thought by many to be the most promising—a cap on the amount of resources an individual must spend on their own care—was mentioned in a progress report alongside the white paper but was not included in the paper itself.
The suggested cap of £35,000, advocated by the independent Dilnot report last year, has been heavily debated across party lines.
The Dilnot report argued that such a cap would both protect government from astronomical care costs and encourage individuals to take out social care insurance to help cover their contribution.
NHS statistics suggest the average lifetime cost of social care is £30,000, with one in ten individuals facing care of £100,000.
Today, the government laid out some alternative options for funding social care changes—including a fee to opt into the system and higher cap than the initially proposed £35,000.
Speaking to the House of Commons, Andrew Lansley said that although a cap was the "right basis" for reform, the government needed to explore cheaper options for changing the system.
Experts estimate the £35,000 cap would cost the government £1.7 billion per year.
Emphasising the need for clarity about how government will deal with the funding crisis, Michelle Mitchell of Age UK said: "The proposals will not live up to ambition without the solid foundation of a fair and sustainable funding structure.
"We need the government to make it clear how reforms will be funded and set out a clear timetable."
Local Government Association chairman, Sir Merrick Cockell, agreed. "There is an immediate crisis in social care which needs to be urgently addressed now," he said.
"No-one would disagree that care should focus on an individual's needs, but attempts to improve the quality of care are meaningless if there is no money for councils to provide these services."
Although financial reform of the social care system is the most prominent issue to be resolved, the white paper also advocated a variety of other measures.
Recommendations included more consistency in the services provided by local councils and measures to allow individuals control over the type of care they receive.
One controversial proposal in the white paper is for a "universal deferred payment" program. This program would allow those needing care to borrow money to pay for care and put off paying back this loan until after their death.
These "pay when you die" policies currently offered by some councils are designed to decrease the number of the elderly who must sell their homes to pay for nursing home care.
Opponents argue the interest that accumulates on these loans is unfair and deters the elderly from taking advantage of these programs.
Responding to Lansley in the House of Commons, Burnham said he welcomed some of the coalition's recommendations—such as the proposal on deferred payments—but accused to coalition of having a "pick and mix" approach to the Dilnot report.
He argued that the Dilnot report should be implemented as a complete package if it is to work effectively.
Yet despite criticism, Lansley praised the historic nature of the government's proposed reforms, saying: "Our plans will bring the most comprehensive overhaul of social care since 1948."
"It will mean that people get the care and support that they need to be safe and to live well so they don't reach a crisis point."


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The MCWD regularly hosts, or helps host, educational workshops and events to raise awareness of water quality issues in the District. See upcoming and past events below:
Minnehaha Creek Watershed District 15320 Minnetonka Blvd, Minnetonka, MN 55345 Office 952-471-0590 - Fax 952-471-0682Office hours: Monday - Friday, 8:00am - 4:30pm
Copyright © 2019 Minnehaha Creek Watershed District. All rights reserved.
Downloadable documents on this site require Adobe Acrobat Reader. Click to get a free copy. Site design by: Creed Interactive - Minneapolis Web Design


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🇯🇪 Jersey Post has come up with a whimsical approach to the COVID-19 theme which has resulted in a set of 8 stamps needing to be issued on 1 March 2021. The title of the issue notes the 'lockdown' which has shut down the island for a sustained period as a means of preventing the rampant coronavirus from spreading among the island's residents. One Jersey resident, Berni Martin of St Brelade, resolved to pass the period of enforced isolation by painting a fanciful picture of a bird each day for 100 days and some of the results of her labours are used as designs for the new stamps which are at least an original and cheerful approach to the philatelic commemoration of this gruelling period in our modern history which has yet to see its endgame. The issue's title is 'Flockdown'. The stamps are self-adhesive and were lithographed by Cartor. Rating:- ***.
🇨🇦 In Blog 1806 I illustrated the sheetlet of 12 stamps due to be released by Canada Post on 15 January 2021 to mark the end of its Lunar new year series. The stamps will also be issued in self-adhesive format in booklets of 12 as depicted below and the 12 accompanying miniature sheets will be rereleased in a 'press sheet' which must be an enormous item for which I can find no use at all. I mean, what do you do with the things when you've spent a lot of money on them?
🇮🇪 An Post, the postal service of the Irish Republic has released details of its planned new stamp issues for 2021:-


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Women's Journee Collection Bellamy Booties
Item # 109245
$99.99 $69.98
Size Chart
Please select all product options to view availability:
- Ship it
Receive in 4-7 business days with standard shipping
- Buy online, pick up in store
Orders are typically ready within 4 hours
The Bellamy bootie by Journee Collection is about to become your new favorite go-to this season! The deep �V� center cut creates an intoxicating bootie. The textured pattern plus the faux leather material and the slip-on style makes this bootie appealing for all ages. The almond toe shape is perfect for your every day wear. Try it out today!
- Faux leather
- Pull-on entry
- Approx. 3 inch stacked heel
- Foot flattering almond toe
- Padded insole for added comfort
- Synthetic outsole
- Deep "V" center cut detail for added style


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Factors Predicting Systemic Inflammatory Response Syndrome in Cranial Surgery Patients
Keywords:systemic inflammatory response syndrome, craniotomy, blood glucose, comorbidity, age
Objective: To study the predicting power of age, comorbidity, blood glucose and types of surgery on cranial surgery patients systemic inflammatory response syndrome (SIRS).
Design: Predictive correlational research.
Methodology: The sample consisted of 164 cranial surgery patients in the intensive care unit of a tertiary hospital. The study was conducted within the frst 24 hours after their operations. The research instruments were 1) a personal information form; 2) a comorbidity assessment form; and 3) a systemic inflammatory response syndrome (SIRS) scoring form. Binary Logistic Regression Analysis was employed for data analysis, with the level of statistical signifcance set at .05.
Results: The incidence of SIRS was found in 49.4% of the patients. Age and blood glucose levels were identifed as signifcant factors capable of predicting 24% of SIRS incidence (at .05, Nagelkerke R2 = .24, p < .01). Comorbidity and surgery types, on the other hand, were incapable of signifcantly predicting SIRS.
Recommendations: It is recommended that nurses apply the data on every cranial surgery patients age, blood glucose level and SIRS score to assessing their post-operative condition, as part of the process of monitoring all the risk-group patients for clinical signs of inflammation and alleviating their systemic inflammation.
2. Tam AK, Ilodigwe D, Mocco J, Mayer S, Kassell N, Ruefenacht D, et al. Impact of systemic inflammatory
response syndrome on vasospasm, cerebral infarction, and outcome after subarachnoid hemorrhage: exploratory analysis of CONSCIOUS-1 database. Neurocrit Care 2010;13(2):182-9.
3. Singer M, Deutschman CS, Seymour CW, ShankarHari M, Annane D, Bauer M, et al. The third international consensus defnitions for sepsis and septic shock (Sepsis-3). JAMA 2016; 315(8):801-10.
4. Chao A, Chou W-H, Chang C-J, Lin Y, Jr., Fan S-Z, Chao A-S. The admission systemic inflammatory
response syndrome predicts outcome in patients undergoing emergency surgery. Asian J Surg 2013; 36(3):99-103.
5. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference:defnitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20(6):864-74.
6. Dieleman JM, Peelen LM, Coulson TG, Tran L, Reid CM, Smith JA, et al. Age and other perioperative
risk factors for postoperative systemic inflammatory response syndrome after cardiac surgery. Br J Anaesth 2017;119(4):637-44.
7. Kulpho Y, Thosingha O, Danaidutsadeekul S, Kongsayreepong S. Predicting factors for systemic inflammatory response syndrome during the frst 24 post-operative hours in abdominal surgery patients. Thai J Nurs Res 2014;29(1):5 -14. (In Thai)
8. Chaikittisilpa N, Krishnamoorthy V, Lele AV, Qiu Q, Vavilala MS. Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury. J Neurosci Res 2018;96(4):661-70.
9. Srivisai T, Pinyopasakul W, Charoenkitkarn V. Relationships between age, body mass index, comorbidity and systemic inflammatory response syndrome in patients with respiratory infection at an emergency unit. Rama Nurs J 2558;21(2):186 - 98. (In Thai)
10. Bhattacharjee S, Layek A, Maitra S, Sen S, Pal S, Gozi NK. Perioperative glycemic status of adult traumatic
brain injury patients undergoing craniotomy: a prospective observational study. J Neurosurg Anesthesiol 2014;26(4):313-9.
11. Chen S, Li Q, Wu H, Krafft PR, Wang Z, Zhang JH. The harmful effects of subarachnoid hemorrhage on
extracerebral organs. Biomed Res Int. 2014;2014:858496. doi: 10.1155/2014/ 858496.
12. Saetung H, Thosingha O, Danaidutsadeekul S,Tantiwongkosri K. Relationship between blood loss, blood glucose level and serum magnesium level and multiple-organ dysfunction within the frst 24 hours after open-heart surgery. Thai J Nurs Res 2014;29(3):80-91. (In Thai)
13. Alazawi W, Pirmadjid N, Lahiri R, Bhattacharya S. Inflammatory and immune responses to surgery and
their clinical impact. Ann Surg 2016;264(1):73-80.
14. Ramona Browder Lazenby. Handbook of pathophysiology. 4 ed. China: Wolters Kluwer Health; 2011.
15. Chen S, Yang Q, Chen G, Zhang JH. An update on inflammation in the acute phase of intracerebral
hemorrhage. Transl Stroke Res 2015;6(1):4-8.
16. Alan N, Seicean A, Seicean S, Neuhauser D, Weil RJ. Impact of preoperative anemia on outcomes in
patients undergoing elective cranial surgery. J Neurosurgery 2014;120(3):764-72.111
17. Fernandes D, Goncalves-Pereira J, Janeiro S, Silvestre J, Bento L, Povoa P. Acute bacterial meningitis in the
intensive care unit and risk factors for adverse clinical outcomes: retrospective study. Journal of critical care
18. Jafar N, Edriss H, Nugent K. The effect of short-term hyperglycemia on the innate immune system. Am J
Med Sci 2016;351(2):201-11.
19. Finnerty CC, Mabvuure NT, Ali A, Kozar RA, Herndon DN. The surgically induced stress response. JPEN J
Parenter Enteral Nutr 2013;37(5 Suppl): 21s-9s.
20. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation
and regression analyses. Behav Res Methods 2009;41(4):1149-60.
21. Jacome T, Tatum D. Systemic inflammatory response syndrome (SIRS) score independently predicts poor
outcome in isolated traumatic brain injury. Neurocrit Care 2018;28(1):110-6.
22. Charlson Mary E., Charlson Robert E., Peterson Janey C., Marinopoulos Spyridon S., Briggs William M.,
Hollenberg James P. The Charlson comorbidity index is adapted to predict costs of chronic disease in primary
care patients. J Clin Epidemiol 2008;61(12): 1234-40.
23. Baek JH, Kim MS, Lee JC, Lee JH. Systemic inflammation response syndrome score predicts the
mortality in multiple trauma patients. Korean J Thoracic Cardiovascular Surg 2014;47(6):523-8.
24. Maneeprasit M, Sindhu S, Danaidutsadeekul S, Tantiwongkosri K. Factors related to systemic
inflammatory response syndrome (SIRS) of coronary artery disease patients in the frst 24 hours after open
heart surgery. JRTAN 2016;17(3):63-72.
25. Schifman RB, Howanitz PJ, Souers RJ. Point-of-care glucose critical values: A Q-Probes study involving
50 health care facilities and 2349 critical results. Arch Pathol Lab Med 2016; 140 (2):119-24.
26. Niven DJ, Rubenfeld GD, Kramer AA, Stelfox HT. Effect of published scientifc evidence on glycemic
control in adult intensive care units. JAMA Intern Med 2015;175(5):801-9.
27. Scott MJ, Miller TE. Pathophysiology of Major Surgery and the Role of Enhanced Recovery Pathways
and the Anesthesiologist to Improve Outcomes. Anesthesiol Clin 2015;33(1):79-91.
28. Dieleman JM, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, et al. Intraoperative highdose dexamethasone for cardiac surgery: a randomized controlled trial. JAMA 2012;308(17): 1761-7.
29. Lineberry C, Stein DE. Infection, sepsis, and immune function in the older adult receiving critical care. Crit
Care Nurs Clin North Am 2014;26(1):47-60.
30. Rau C-S, Wu S-C, Chen Y-C, Chien P-C, Hsieh H-Y, Kuo P-J, et al. Stress-induced hyperglycemia, but
not diabetic hyperglycemia, is associated with higher mortality in patients with isolated moderate and
severe traumatic brain injury: analysis of a propensity score-matched population. Int J Environ Res Public
Health 2017;14(11):1340.
31. Daniel R, Villuri S, Furlong K. Management of hyperglycemia in the neurosurgery patient. Hosp Pract 2017;45(4):150-7.
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33. Golebiowski A, Drewes C, Gulati S, Jakola AS, Solheim O. Is duration of surgery a risk factor for extracranial complications and surgical site infections after intracranial tumor operations? Acta Neurochir
34. Davis MC, Ziewacz JE, Sullivan SE, El-Sayed AM. Preoperative hyperglycemia and complication risk
following neurosurgical intervention: a study of 918 consecutive cases. Surg Neurol Int 2012;3:49.


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Recycling Christmas Trees
Back in November the Chastain Park Conservancy began selling Christmas trees in the Red lot. If you bought your tree there you could bring it back on Jan 1 & 2 to recycle it and receive a new tree to plant. I guess the only problem was you needed to hold onto your tree until 1/1 or 1/2 which is probably a little long for most folks to hang onto a tree. If you drove by the red lot over the past week you surely saw the tree pile growing outside the fence…
Yesterday I took my Christmas tree back to recycle it and the pile of trees returned as instructed was much smaller than the pile of trees piled up outside the fence. It got me wondering what is going to happen to all of the trees piled up outside the fence?
I wouldn't think they are the responsibility of Barefoot Mountain Farms, or the Conservancy, or the neighborhood…right? I guess we will see… Mulch or not to mulch…
I am excited about planting the red bud sapling that I received yesterday. Hopefully it can survive the Chastain Park winter.
I personally want to thank the Conservancy for putting together this program in Chastain Park and offering the neighbors a simple way to purchase and return a Christmas tree, all while supporting and giving back to the park.
I hope everyone had a wonderful holiday season!


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Garden as metaphor, Part 3…or 4
Can anyone think of a better metaphor for life as a human than a garden?
All the planning, selecting, planting, nurturing, stoking, prodding, coaxing, frustration, re-planting, and finally, after all the work and with some luck, the harvesting of fresh food…this is all just like the bigger things in our lives.
Lately it has been difficult to ignore some generational changes afoot that simply cannot bode well for our nation, now or in the future.
Where debate historically involved logic, facts, and reasoning, a great deal of what is represented as debate is simple ridicule, mockery, dismissiveness.
Few things demonstrate the weakness of an argument more than the use of ridicule and mockery, or name-calling. Yet the Internet is full of this waste of time. Because of my own passion for and involvement in tough policy issues, I am really interested to hear separate points of view from people, and spirited debate, give-and-take, is part of that process. This process is what makes Western Civilization so unique and so precious.
Dismissiveness assumes all will be well, no matter what, irrespective of actions or behaviors across the landscape.
In my observation, the younger generations are much more inclined to forgo logic and facts, and are more inclined to leap into name calling and ridicule in their online debates. This just cannot bode well for American democracy, which is based on the use of logic, reason, and facts. How our citizens expect to hold on to their Constitutional rights and liberties, and yet allow debate to be dominated by juvenile behavior is not wild speculation. Already we have witnessed the erosion of individual liberties at the hands of judges who don't care what the US Constitution says, or what their particular state constitution says; their basis for decisions making is purely personal, or political.
So go grow a garden, fellow citizens. Tending even a small garden helps us work physical and mental muscles that atrophy easily. It builds small but important personal traits that are needed on a much bigger scale. Tending, cultivating, and nurturing all build basic skills necessary for us to function well as individuals and for our civilization to succeed on the whole.
The alternative – relying on everyone else for everything else we need, and ridiculing the rest – is a recipe for disaster.
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TMC Tropic Marin Phosphate Pro Test Kit
- Regular price
- £26.99
- Sale price
- £26.99
Tropic Marin Phosphate Pro Test Kit is a high precision test kit ensuring accurate results for testing Phosphate in your fish tank.
Pay up to 30 days later or split your payment into three with Klarna.
Click here for more info.
- Product Description
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Product Description
The phosphate concentration in natural saltwater is approximately 0.06 mg/l (ppm). However, the phosphate concentration in coral reefs may be much lower, typically between 0.01 and 0.02 mg/l (ppm). The objective is to establish an appropriate level in relation to the number and type of aquarium inhabitants. In freshwater applications, a phosphate concentration of up to 0.4 mg/l (ppm) is suitable; however 1 mg/l (ppm) should not be exceeded. Even a concentration of 0.02 mg/l (ppm) is adequate for supplying aquatic plants with nutrients. Therefore, the phosphate concentration in the aquarium water should be tested regularly.
With the high resolution Tropic Marin Phosphate-Test Professional the phosphate concentration can be determined with a particularly high accuracy in the low concentration range between 0.01 and 1 mg/l.
- Measurement range: 0.01 - 1.0 mg/l (ppm)
- Accuracy: 0.02 mg/l (ppm)
- For determining the phosphate concentration in aquaria
- Incl. comparator and phosphate standard to check function and shelf life of the test reagents
- Sufficient for approximately 50 applications
How to use:
- Shake the dropper bottles before use! Assemble and prepare the comparator.
- Rinse out both glass cuvettes with tap water and then several times with aquarium water.
- Fill each glass cuvette with exactly 5 ml of aquarium water using the dosing syringe. Put one of the two water samples aside as a reference.
- Add 10 drops (for saltwater) or 12 drops (for freshwater) of test reagent A to the test cuvette, close the glass cuvette using the stopper and briefly shake the sample.
- After that, add 4 drops of test reagent B, close the glass cuvette once again and briefly shake it.
- After 2 minutes of development time place the open test cuvette and the reference cuvette with the water sample into the comparator. Place the comparator on the colour card in such a way that the reference cuvette is sitting on a coloured field and the test cuvette on a white field
- Now compare the opposing fields. To do this, look into the open cuvettes from above. Move the comparator on the colour card until both cuvettes match exactly.
- Read off the phosphate concentration under the relevant colour field. If the colours do not match exactly, an intermediate value can be estimated.
- Rinse out the glass cuvettes and the syringe thoroughly with tap water after the measurement process.
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Delivery & Returns
We really want you to be happy with the product that you've received. If however, when the goods arrive they're not what you want, then no problem - we have a 60 day no quibble return guarantee. Just let us know that you're going to return the item(s) by contacting us (stating your Order Number) and complete the returns packing slip that will have been included with your delivery. This will help us to quickly identify the item that you have returned (unopened and unused) - and we'll put a refund through for you.