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Hilleman Labs inks MoU with ICMR to develop new vaccine for diarrheaThursday, March 30, 2017
Mumbai, March 30 -- Hilleman Laboratories, a non-profit joint venture of pharmaceutical major Merck, Sharp & Dohme and UK-based Wellcome Trust, on Wednesday signed a memorandum of understanding with National Institute of Cholera and Enteric Diseases (NICED), a part of Indian Council of Medical Research's (ICMR), to develop a new vaccine for diarrhoea caused by Shigella bacteria. Hilleman Labs will take the lead in further development of the vaccine candidate for which NICED has already conducted initial research and also be responsible for its regulatory filings and commercialization, said Davinder Gill, chief executive officer of the company. NICED will provide support in the research studies. Shigellosis is one of the leading causes of death among children under five years of age, especially in low-income developing countries of Africa and South Asia. "Candidate vaccine against the infection have been developed and tested at NICED by using the in-vitro animal models, which showed significant immune response and protection against the infection," Shanta Dutta, director of NICED, said. Hilleman Labs is also developing four other vaccines for diarrhoeal diseases. Its rotavirus vaccine is in phase-II clinical trials and the company is in discussions with various companies for potential out-licensing or partnerships.


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Our client is an internationally operating car rental company with its headquarters in Thessaloniki and other offices, e.g. in Germany. The product portfolio includes car rental, corporate leasing and VIP transfer.
- Building relationships with hotels, airlines and other organizations in order to expand the business portfolio
- Planning and overseeing new marketing initiatives
- Researching new B2B opportunities
- Finding and developing new markets and improving sales
- Attending conferences, meetings, and industry events
- Developing quotes and proposals for clients
- Degree in Business Administration is other related studies
- +5 years of B2B Sales experience (preferred fields: car rental, hotel sales, general tourism)
- Languages: Mandatory – Greek, English, Nice to have: German
- Strong communication skills and IT fluency
- Ability to manage complex projects and multi-task
- Excellent organizational skills
- Ability to flourish with minimal guidance, be proactive, and handle uncertainty
Our client offers:
- Opportunities for professional development in Greece and abroad
- Long-term collaboration and a personalized advancement plan
If you are interested, please apply directly via the form below or through [email protected] It is necessary to attach your CV and related documents.

subset: commoncrawl


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What is pulmonary hypertension (PH)?
Pulmonary hypertension (PH) is abnormally high blood pressure that occurs in the arteries of the lungs (the pulmonary arteries). To understand pulmonary hypertension, it's good to first know how the respiratory and circulatory systems work together. Keep in mind that the left and right sides of the heart have essentially different jobs.
- When you inhale, you breathe oxygen into your lungs. That oxygen is transferred to blood cells, and that blood (now "oxygenated") is collected in the left side of the heart.
- The heart pumps out the oxygenated blood (through the arteries) to supply the rest of the body with oxygen.
- The blood – now devoid of oxygen – travels back (through the veins) to the right side of the heart.
- The right side of the heart collects the de-oxygenated blood, and pumps it (through the pulmonary artery) into the lungs.
- Then the cycle begins again: In the lungs, the blood cells drop off carbon dioxide (for us to exhale), picks up the oxygen that we inhale, and re-collects in the left side of the heart.
Some cases of PH have no identifiable cause (idiopathic pulmonary hypertension). However, genetic defects and immune system disease may be contributing factors to the development of this disease.
Another type of PH, called secondary pulmonary hypertension, occurs when the arteries in the lungs become too narrow for blood to flow through the vessels normally or because there are too few vessels to begin with. As a result, the heart works harder to pump blood through the lungs, causing pressure in the pulmonary artery to rise. Narrowing of the vessels in secondary hypertension can be caused by an associated medical condition such as blood clots, congenital heart defects, and liver disease.
The first symptoms of PH are typically shortness of breath during mild physical activity, although some patients may have fainting spells, especially with exercise. However, because the symptoms of PH aren't specific to the condition, it can be difficult to diagnose.
While for most patients there is no "cure" for pulmonary hypertension, certain medications can help lessen symptoms and improve lung and heart function. Careful monitoring by a cardiologist can help your child live as normal life as possible.
What are the types of pulmonary hypertension?
Pulmonary hypertension can be grouped into one of two categories, depending on what we know about what is causing it:
Idiopathic pulmonary hypertension (IPH)
- This diagnosis means that there is no clear cause of your child's pulmonary hypertension.
- IPH occasionally runs in families, and sometimes the BMPR2 gene (or another gene) is involved.
Secondary pulmonary hypertension
This diagnosis means that the pulmonary hypertension is thought to be caused by or associated with something else. Possibilities include:
- some congenital (present at birth) abnormalities of the heart
- some lung diseases, often related to prematurity
- diseases that primarily affect other organs, such as scleroderma, some liver diseases, hereditary hemorrhagic telangiectasia, AIDS/HIV, and sickle cell disease
- abnormal function of the left ventricle
- chronic thromboembolic disease, in which many small blood clots formed elsewhere travel into the lungs and are lodged there
- environmental factors, such as exposure to the drugs fenfluramine and dexfenfluramine (Fen-phen) or living at very high altitudes
It's extremely important to learn whether your child's PH is idiopathic or secondary, and if secondary, what is causing it — this is how your child's doctor will determine the treatment plan.
Pulmonary Hypertension | Symptoms & Causes
What are the symptoms of pulmonary hypertension?
Initial symptoms of PH are often minor, but slowly get worse over time. These symptoms can also occur as parts of other diseases, which can make it challenging for doctors to detect PH early. Be sure to consult your doctor if you experience any of the following symptoms.
The most common signs and symptoms of pulmonary hypertension are:
- shortness of breath while performing everyday activities (walking or climbing stairs)
- excessive fatigue
- fainting spells
- dizziness
- rapid heart beat
- low blood pressure
- swelling of legs and hands
What causes pulmonary hypertension?
Unfortunately, it's a complicated question. We know that PH occurs when the heart has to work extra hard to move blood through the very small vessels of the pulmonary artery to the lungs, eventually causing the heart muscle to weaken. At the most physical level, this might occur for one or both of two reasons:
There are fewer of these small vessels. This may be because:
- fewer of them develop as the lung grows
- they become blocked off by small blood clots
- they become blocked off by the thickening of the intima (the lining of the artery)
The vessels are smaller than normal in diameter. This may be due to:
- an increased number and/or size of cells (smooth muscle and other types of cells)
- connective tissue disorders
- blood clots that form in the lungs
- congenital heart defects
- chronic liver disease
- sleep apnea
Researchers aren't sure why these things happen, but many people group together types of PH based on presumed cause.
Pulmonary Hypertension | Diagnosis & Treatments
How do we diagnose pulmonary hypertension?
Measuring pulmonary blood pressure
- A pediatric cardiologist or other physician will perform a physical examination, listening to your child's heart and lungs.
- An echocardiogram (a test which uses sound waves to determine and structure and function of the heart) will sometimes, but not always, give an accurate idea of pulmonary artery pressure. This test is painless, takes about 30 minutes, and is easily performed in the doctor's office. In order to get the clearest images possible, it's important for children to cooperate and hold very still. Children younger than 3 who are restless may be given a medication (a sedative) to help them relax during a length procedure.
- Cardiac catheterization is a procedure that gives us very detailed information about the structures inside the heart muscle. In some cases, we may need your child to stay overnight in the hospital for this test.
Other tests your child's doctor may order include:
- Blood tests may help identify the underlying cause of the pulmonary hypertension as well as related medical conditions that occur as a result of the high blood pressure.
- CT scans of the chest show the lungs in more detail than a chest x-ray and better detects certain problems.
- Cardiac MRI is a non-invasive test that shows the structure and function of the heart without the radioactive radiation used in x-rays.
- Pulmonary function tests measure breathing and lung capacity.
- Ventilation and perfusion scans: Oxygen and a special type of test medicine is inhaled or injected into a vein in your child's arm to determine the path of air and blood flow within the lungs.
After all necessary tests are completed, experts at Boston Children's Hospital meet to review and discuss what they have learned about your child's condition. Then we'll meet with you and your family to discuss the results and outline the best treatment options.
How we treat pulmonary hypertension
While no cure has been found for secondary or idiopathic pulmonary hypertension, there are several treatments that can decrease pulmonary arterial pressure and improve your child's symptoms.
For idiopathic PH in particular, treatment is aimed at alleviating and controlling symptoms. This may be done using medication. Only in severe cases is surgery needed.
Secondary pulmonary hypertension
The most common types of treatments used for secondary pulmonary hypertension include:
- Inhaled oxygen to help raise the levels of oxygen in the bloodstream. This may be particularly helpful while sleeping, when your child may breathe less strongly than when he's awake. Oxygen is given by two small tubes in the very front of the nose ("nasal cannula"), and can help your child even when she is walking about.
- Inhaled nitric oxide (iNO) to relax pulmonary blood vessels. Given just like inhaled oxygen, iNO is typically used in children hospitalized for short-term therapy (usually hours or days) or for testing the pulmonary arteries during heart catheterization.
- Medications that help to relax pulmonary blood vessels, making it easier for your child's heart to pump blood. These come in several different forms: oral (pill), inhaled, or injected through the skin.
- Anticoagulants can prevent blood clots in your child's lungs.
- Diuretics can help your child's kidneys eliminate water.
- Atrial septostomy may be used in severe cases of pulmonary hypertension if medication fails to control the child's right ventricle from working very hard to pump blood. This surgery is done in the catheterization laboratory. During the procedure, a small hole is created between the upper chambers of your child's heart muscle, redirecting some of the flow of blood past the right ventricle to the left ventricle.
- A new, experimental form of therapy, called the transvascular Potts procedure, is being pioneered at Boston Children's. In this procedure, a small shunt is placed between the pulmonary artery and the aorta (main artery to the body), to increase blood flow to the heart and lower blood pressure.
- Lung transplantation may be an option for some patients who do not respond to medication.
The mission of the Pulmonary Hypertension Program is threefold:
- Provide the best possible care for our patients. Ours is a multidisciplinary approach using experienced physicians and other clinical professionals who have expertise in specific areas. Your child's care may also involve consultation with specialists at other institutions, to make sure that we bring the best collective knowledge to each case.
- Advance our understanding of pulmonary hypertension and develop new therapies. This serves both current and future patients: Our clinical trials regularly bring new treatments to our patients sooner than would be otherwise possible.
- Train new practitioners. As a program with enormous experience in treating children with pulmonary hypertension, it's our responsibility to help train the next generation of professionals dedicated to curing this disease.
Pulmonary Hypertension | Research & Clinical Trials
Boston Children's Hospital is home to the world's most extensive research enterprise at a pediatric hospital. We also have many partnerships with the top research, biotech, and health care organizations, and we work together to find innovative ways to improve kids' health.
Thanks to advances in basic science and clinical research, better therapies for pulmonary hypertension are being developed every year.
- We are a leader in the use of nitric oxide, prostacyclin analogs, endothelin antagonists, and other investigational therapies to treat both idiopathic and secondary pulmonary hypertension in children.
- Researchers and doctors have conducted a quality of life study for patients with pulmonary hypertension in an effort to identify strategies to improve development.
Current therapeutic trials include:
- evaluation of a new, more efficient way of delivering inhaled nitric oxide
- study of the long-term effects of ambrisentan. Used to treat PH, this medicine can help make exercise and breathing easier.


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Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 8
Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities
Authors Oh YM , Bhome A, Boonsawat W, Gunasekera KD, Madegedara D , Idolor L, Roa C, Kim WJ , Kuo H, Wang C , Lan LTT, Loh LC , Ong C , Ng A, Nishimura M , Makita H, Silverman E, Lee JS , Yang T, Lin X, Wang C , Lee SD
Received 23 July 2012
Accepted for publication 27 September 2012
Published 14 January 2013 Volume 2013:8 Pages 31—39
DOI https://doi.org/10.2147/COPD.S36283
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Yeon-Mok Oh,1 Arvind B Bhome,2 Watchara Boonsawat,3 Kirthi Dias Gunasekera,4 Dushantha Madegedara,5 Luisito Idolor,6 Camilo Roa,6 Woo Jin Kim,7 Han-Pin Kuo,8 Chun-Hua Wang,8 Le Thi Tuyet Lan,9 Li-Cher Loh,10 Choo-Khoon Ong,10 Alan Ng,11 Masaharu Nishimura,12 Hironi Makita,12 Edwin K Silverman,13 Jae Seung Lee,1 Ting Yang,14 Yingxiang Lin,14 Chen Wang,14 Sang-Do Lee1
1Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 2Department of Pulmonary and Critical Care, "Friends of the Breathless" Foundation, Pune, India; 3Department of Medicine, Khon Kaen University, Khon Kaen, Thailand; 4Central Chest Clinic, Colombo and National Hospital of Sri Lanka; 5Respiratory Disease Treatment Unit and Teaching Hospital Kandy, Sri Lanka; 6Section of Respiratory Services and Physical Therapy and Rehabilitation Lung Center of the Philippines, Quezon City, Philippines; 7Department of Internal Medicine, Kangwon National University, Kang Won, Korea; 8Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan; 9Respiratory Care Center, University Medical Center Ho Chi Minh City, Vietnam; 10Department of Medicine, Penang Medical College, Penang, Malaysia; 11Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore; 12Division of Respiratory Medicine, Department of Internal Medicine, Hokkaido University Hospital, Sapporo, Japan; 13Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 14Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
All authors made an equal contribution to this study
Background and objectives: Chronic obstructive pulmonary disease (COPD) is responsible for significant morbidity and mortality worldwide. We evaluated the characteristics of stable COPD patients in the pulmonology clinics of seven Asian cities and also evaluated whether the exposure to biomass fuels and dusty jobs were related to respiratory symptoms, airflow limitation, and quality of life in the COPD patients.
Methods: This cross-sectional observational study recruited 922 COPD patients from seven cities of Asia. The patients underwent spirometry and were administered questionnaires about their exposure to cigarette smoking, biomass fuels, and dusty jobs in addition to respiratory symptoms and health related quality of life.
Results: Of the patients, there appeared to be variations from city to city in the history of exposure to biomass fuels and dusty jobs and also in respiratory symptoms of cough, phlegm, wheeze, and dyspnea. These symptoms were more frequent in those COPD patients with a history of exposure to biomass fuels than without and those with a history of exposure to dusty jobs than without (P < 0.01 for all comparisons). Airflow limitation was more severe in those COPD patients with a history of exposure to biomass fuels than without (52.2% predicted versus 55.9% of post-bronchodilator forced expiratory volume in 1 second [FEV1], P = 0.009); quality of life was poorer in those with exposure to biomass fuels than without (40.4 versus 36.2 of the St George's Respiratory Questionnaire [SGRQ] total score, P = 0.001). Airflow limitation was more severe in those COPD patients with a history of exposure to dusty jobs than without (51.2% predicted versus 57.3% of post-bronchodilator FEV1, P < 0.001); quality of life was poorer in those with dusty jobs than without (41.0 versus 34.6 of SGRQ score, P = 0.006).
Conclusion: In Asian cities, the characteristics of COPD patients vary and the history of exposure to biomass fuels or dusty jobs was related to frequency of symptoms, severe airflow limitation, and poor quality of life.
Keywords: COPD, Asia, biomass, dust
© 2013 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.


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Like washing your hair, your dishes, or even your clothes, washing your makeup brushes is one of those annoying tasks that you're probably not doing often enough. But, don't think you can just run them under warm water or rub them with sanitizer and call it a day; there's a technique to making sure you're getting rid of the bacteria and taking care of your bristles. Here's exactly how the experts say you should do it.
You should be washing your brushes at least once a week.
According to celebrity makeup artist Allan Aponte, the brushes you use the most—i.e. usually your foundation and concealer brushes—should be cleaned once a week while everything else is usually fine to only be cleaned once or twice a month.
Brushes that you get wet or use liquid products with are also more important to keep clean because "moist environments allow for an overgrowth of bacteria and fungi," says dermatologist Joshua Zeichner, MD, director of cosmetic and clinical research in dermatology at Mount Sinai Hospital in New York City. This is especially crucial if you have sensitive or acne-prone skin.
More From Women's Health
Only wash the tips of your bristles.
Rather than dunking your whole brush head into a bowl of water, Aponte suggests only getting the ends of your bristles wet under lukewarm, running water. "Submerging the whole brush head will eventually dissolve the glue that holds the brush together," explains Aponte.
Use a gentle, fragrance-free shampoo.
Aponte prefers baby shampoo over regular soap because it "still suds up and gets rid of dirt and oils but it won't dry out the bristles." His favorite one is the Aquaphor Baby Wash and Shampoo. In a bowl, pour a two to one ratio of water and shampoo. Dip the bristles into the mixture, then brush them from side to side in the palm of your hand until they lather up before rinsing under warm water. Continue this lather and rinsing cycle until the water running through your brush turns clear.
Do not use a blow dryer on your makeup brushes.
Once your brushes are clean, squeeze out the excess water with a paper towel then lay them flat onto a counter, with the bristles hanging over the edge to finish drying. "Never let your brushes dry upright as the water can go down the barrel that hold the bristles together and loosen the glue," explains Aponte.
You should replace your brushes at least once every year.
Maybe even more often if you use your brushes more frequently. Aponte says there are a few signs to look for, including if it's lost its shape, if the base of the brush head is shaking, if your bristles are constantly shedding, and if it's lost its fullness.
Chelsea Burns is the Beauty Director for Women's Health and has been writing in the beauty and wellness space for over six years with her work appearing in Real Simple, Health, Fitness, and Byrdie.com. She's an expert at testing products and is always on the hunt for the best tinted moisturizer.


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Trade in commercial services
China may have overtaken Germany to become the world's largest exporter of goods during 2009, but America remained the biggest exporter of services. During 2009 the value of world exports of services was about a quarter of the value of global trade in goods. According to the World Trade Organisation, America's service exports, which fell by 9% during the year, were 14.2% of the world total for last year. The market share of Britain, the world's second-biggest exporter of services, was just over half that of America. The recession affected trade in both goods and services, but not to the same extent. The value of world merchandise trade shrank by 23% during 2009, whereas trade in services declined by 13%.
This article appeared in the Economic & financial indicators section of the print edition under the headline "Trade in commercial services"
Economic & financial indicators April 17th 2010
From the April 17th 2010 edition
Discover stories from this section and more in the list of contentsExplore the edition


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American humorist Will Rogers, who said "I never met a man I didn't like", built his legendary career on telling jokes about Congress.
In that humble, aw shucks way of his, he said his jokes weren't meant to hurt anybody, but with "Congress, every time they make a joke, it's a law, and every time they make a law it's a joke."
President Trump attempted to make a joke Monday at the National Scout Jamboree, at the expense of his Health and Human Services Secretary, Tom Price, about what would happen to him if he didn't corral the votes needed to repeal and replace Obamacare.
Pointing to Price, a former six-term congressman from Georgia, whom he put in charge of selling the GOP reform bill, Trump said, "By the way, are you going to get the votes? You better get the votes. Otherwise, I'll say, Tom, you're fired."
Firing some of the top people in his administration has been in the forefront of Trump's mind, almost from the time he was sworn into office.
He was forced to get rid of his national security adviser, Michael Flynn, after it was learned that he discussed U.S. sanctions with the Russian ambassador to Washington that Vladimir Putin wants lifted, and lied that he never had any contacts with the Moscow envoy.
He fired FBI director James Comey who was conducting a sweeping investigation into Russian contacts with many of Trump's aides and advisers during the 2016 campaign.
He then forced his press secretary, Sean Spicer, to resign, effective after the end of August, by removing him from the daily press briefings.
And Wall Street financier Anthony Scaramucci is said to be evaluating scores of other aides in the White House for removal and replacement.
But now Trump wants to fire his attorney general, Jeff Sessions, who has also had several discussions with the Russian ambassador, and subsequently recused himself from any and all decisions dealing with Russian meddling and cybersecurity skullduggery in the election.
That meant that the responsibility to fill the vacancy left by Trump's firing of Comey fell to Deputy Attorney General Rod J. Rosenstein who appointed former FBI director Robert S. Mueller III as special counsel with sweeping powers to dig into every aspect of the case, including whether the Trump campaign coordinated with Moscow on ways to influence the outcome of the election.
In recent weeks, the president has lobbed a volley of emailed Tweets expressing his deep disappointment with Sessions, saying that if he'd known the former senator would recuse himself from the investigation, he wouldn't have chosen him to run the Justice Department.
In another tweet on Monday, Trump called Sessions, who was one of his earliest high profile supporters in the 2016 campaign, "our beleaguered A.G", "VERY weak," demanding to know why he was not "looking into Crooked Hillary's crimes & Russia relations."
In yet another battery of tweets this week, Trump wrote: "Why didn't A.G. Sessions replace Acting FBI Director Andrew McCabe, a Comey friend who was in charge of Clinton investigation but got big dollars ($700,000) for his wife's political run from Hillary Clinton and her representatives. Drain the Swamp!"
That begs the question why the president doesn't just replace McCabe himself.
Trump's escalating pressure on Sessions to resign has been relentless, but he's refused to do so, effectively daring his boss to fire him, which would ignite a political firestorm in the government, especially in Congress where Sessions is widely respected on both sides of the political aisle.
"I don't think it helps to throw your own people under the bus," said GOP Rep. Tom Cole of New York.
"Jeff Sessions is a man of integrity, loyalty, and extraordinary character," says Republican Sen. Richard Shelby of Alabama.
But Trump's chief target is Mueller. His plan is to get rid of Sessions and then install an acting attorney general in a recess appointment during Congress's month long August vacation — someone who would fire Mueller in an attempt to end or at least curtail the investigation.
This would allow Trump's appointee to avoid the Senate confirmation process and serve in that post through the end of next year.
All of this raises deeper questions about the stability of Trump's government.
Nearly six months into his presidency, he is still in the midst of rearranging the deck chairs in his administration, with scores of key administrative posts remaining unfilled.


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Corrected entry: The American troops were issued 30 caliber Krag-Jorgensen breech loading rifles, yet, at the 1:13 hour on the second disc, a trooper is firing what appears to be a civil war-era percussion muzzle loader.
Correction: It is true that the main issue weapon for the US Army in 1898, was in fact the Krag Rifle .30-40 Army. It was only issued to regular infantry, and the carbine was issued to the US Cavalry. Several units STILL had the 1873 .45-70 Govt Springfield Rifle and Carbine, due to lack of money spent by the government to acquire the newly adopted longarm. Along with this, the mixed issuance of both the .45 Colt Peacemaker and the 1890 double action .38 spl Colt and Smith and Wesson revolvers. With National Guard units participating in the campaign, many still had the 1873 Springfield in their armories. My Great Grandfather served with the 1st Vol. Cavalry, which has several National Guard units supporting it, and noted the difference of weapons carried by members of several units. Some had their own sidearms, and a few in the Guard units had brought their own lever action Winchester rifles, many chambered in the older .45-70 Govt round, like shown in the scene with Frederic Remington painting.


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Overnight, reports circulated about Facebook and Instagram going dark. Now, Lizard Squad is claiming to have taken down a large handful of sites—albeit briefly.
Reports suggest that Facebook, Instagram, Tinder, MySapce, AIM and Hipchat at the very least were affected by the alleged attack. All those sites are definitely now back up and running properly, and reports about how long there were down varies—certainly less than an hour for Facebook, though.
It's a short, sharp impact but on wide selection of sites. Indeed, if its is the work of Lizard Squad, the ability to take out such a wide range of sites in one go is worrying. We currently have no more details, but will update if we find out more.
Update: A Facebook spokesperson has told The Verge that this was "not the result of a third party attack but instead occurred after we introduced a change that affected our configuration systems." It's suspected that the Tinder outage may have been triggered by the Facebook outage.


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Here's something different for you this Friday, dear readers: A music-analysis essay! Well, my attempt at one, anyways XD I don't have much of a grounding in music theory, but I was asked to write on it by a friend of mine. I showed him my previous entry on The Rise and Fall of the Third Reich and he asked me why I wrote so much concerning Hitler. I asked him if there's anything he'd like to see, and he said music! So I thought I'd give it my best shot and write a music post, though he'd probably be able to do much better…he has some formal music training. Still, I hope he and anyone else coming across this entry will find it interesting, at least 🙂
One series of games I've been playing a lot recently is the Warhammer 40k Dawn of War, and one series I used to play a lot was Castlevania. One subject I was and still am quite interested in is religion. I'll talk about all three of these here, specifically the different ways in which Warhammer and Castlevania games make use of religious music. Both do, after all. It may sound strange to readers who aren't familiar with the properties, so let me give you a brief introduction to both.
I described the Warhammer 40,000 universe in a bit more depth here (my entry on grimdarkness XD). To offer a shorter, quicker recap, the setting of 40k is incredibly dystopic, where mankind is ruled by a terrible galactic Imperium which kills billions of its own citizens a day but still isn't as bad as the various space aliens and extradimensional terrors which would otherwise consume everything. The Dawn of War games (DoW I and II, and their expansions) take place within this scary backdrop, and revolve around the toughest of the Imperium's soldiers, the Space Marines. Now, the thing about the Imperium is that it's also a theocracy. All of its citizens, administrators, and soldiers (in theory, at least) worship the Emperor of Mankind as a God, and the religious structure of the Imperium itself is loosely based off of medieval Catholicism. The language of the far-future Imperium is often represented as Latin, there are big gothic cathedrals (some of which are attached to incredibly big robots—this should give you an impression of how over-the-top 40k's setting is XD), and the Space Marines themselves have some similarities to medieval knights. Some space marines, such as the Black Templars, *really* play into this, as their armor has things like a knight's crest and they even use (futuristic) swords and shields, but most of the Marines have this aesthetic to some extent. They certainly recall the portrayal of the medieval knight as a crusader or holy warrior. In all the Dawn of War games, your marines say stuff like "Faith is my shield!" and "Heretics will be purged!" which are the sorts of things you'd expect to hear from the deeply religious.
Castlevania, on the other hand, is quite different. Its first game released in 1986 for the Nintendo Entertainment System. The original Castlevania had nowhere near the elaborate setting and backstory of Warhammer 40,000. It was pretty simple: You were the whip-wielding hero Simon Belmont (in future games, you'd play as his ancestors or descendants), and you had to navigate through a series of side-scrolling, platforming levels to eventually defeat the evil vampire Dracula and stop him from terrorizing medieval Europe. Pretty much all the Castlevania games followed this basic formula, though some don't have a whip-wielding or Belmont-descended protagonist (such as Alucard from Symphony of the Night or Shanoa from Order of Ecclesia), and of course many of the recent games are 3D rather than 2D platformers.
Given the differences between the two game series, you may expect the 40k entries to be the more religiously-tinged of the two, in terms of aesthetics, concepts, and of course music. You'd think Warhammer would have more religious music, right? While gospel tunes would obviously be too upbeat for such a grimdark setting, old-time medieval hymns and Gregorian chants ought to fit right in, especially given how much 40k likes to use Latin in its descriptions. Ironically enough, however, the opposite is true: Castlevania has a much wider array of 'religious' hymnal music, and even the relatively few 'hymnal' tunes or chants found in the Dawn of War games aren't as true to the Catholic source material as Castlevania's.
Now, a brief digression on how I'm using the terms religious music, hymnal, and so on. Again, I've no grounding in music theory, so I can't define liturgical music referring to its specific, technical dimensions of tone, tempo, composition, and so on. However, even I can fall back on a combination of Wikipedia and "I know it when I hear it." I think religious music is songs like this:
Lots of choral singing, backed by an organ, and most importantly, slow-paced with an intent to evoke calm and reflection within the listener.
And this:
A Gregorian chant without any organs or instrumental accompaniment, but sung in a liturgical language (Latin) and also methodically paced, its intent being to evoke calm and reflection in the listener.
Now, let's look at some of the music in the Castlevania and Dawn of War games to see how well each captures the emotions the religious songs I've posted above try to evoke.
These tunes from Dawn of War I and II are pretty emblematic of the music of the games as a whole:
http://www.youtube.com/watch?v=kQ-GU-t2o_U (Space Marine theme from DoW I)
http://www.youtube.com/watch?v=x8qp992Dssk (Space Marine theme from DoW II)
As you can tell, both pieces are very militaristic with few religious elements aside from some chanting in the second one. And even with the chanting, the tempo and background rhythm of the music is clearly meant to evoke a military march, not the calm and contemplation encouraged by actual religious music. There is one song with perhaps slightly more religious content: The theme of the Sisters of Battle from the Dawn of War expansion pack, Soulstorm. The Sisters of Battle are literally nuns, though in the universe of 40k they're a martial order which sees war rather than peace as their religious duty. They have power armor and weapons similar to the Space Marines, though they're not as strong. Check out their theme:
There's an organ, and even some chanting in Latin, but the rhythm of the music is very militaristic, like the Space Marine themes, and instills dread in the listener rather than awe or reflection.
There are a handful of songs in Dawn of War which really capture a religious theme, but there are very few of them. One of those few is this, IMO:
From what I understand, this is a genuine Gregorian chant, and captures the same emotions of calm and reflection 'official' chants are supposed to do.
Now, let's look at some selections of music from the Castlevania games. It's very, very varied, of course, ranging from jazzy/funky pieces like this one to hard rock like this. However, it also has a tremendous amount of genuinely religious music, in my estimation. Check these out:
The menu screen from Rondo of Blood (and several other games) use an actual Christian hymn, the Kyrie Eleison, as their themes.
"Gloomy Memories," from the Dawn of Sorrow OST, isn't exactly a match for the religious music I've shown above, but it comes close and captures a melancholic, sort of contemplative feel, at least moreso than most Dawn of War music.
The password screen of Super Castlevania IV also seems somewhat hymnal in composition and intent, to me.
The beginning of this track from Lament of Innocence, "House of Sacred Remains," would not be out of place in a church service, though I suppose I must note that a lot of this churchy-sounding music is more baroque than ecclesiastical, i.e more melancholy than what you'd see in a real religious service. Still, it captures the reflection and calm encouraged by liturgical music quite well, in my estimation—before the more eclectic main tune kicks in, of course, at around the 1:30 mark.
And, of course, one of my favorite Castlevania songs and pieces of music, period–"Requiem for the Gods" from Symphony of the Night:
Again, more melancholic and generally Baroque than specifically religious, but it comes close to catching that religious theme, IMO.
As you can tell, Castlevania, in general, seems to have more music of a genuinely religious nature in more places than Warhammer 40k: Dawn of War. I could only find one track in the DoW games that wouldn't seem out of place in a religious context, while there are several among many Castlevania games which would—at least to an extent; as I admitted above, they wouldn't fit in perfectly. XD
It may seem somewhat ironic—at first glance—that a series of platforming games about killing vampires has more convincing religious music than games set within a galaxy-spanning medieval Catholic-inspired theocracy. On closer inspection, however, this actually makes sense. Allow me to explain.
The Castlevania mythos, despite ostensibly just being based on some guy fighting Dracula, is suffused with religion. As most of my readers are no doubt aware, in classic tales vampires loath religion and are repelled by religious iconography. In Castlevania, this is a gameplay mechanic; the protagonists of most games can pick up items like crosses to increase their power against Dracula and his minions. Naturally, semi-religious music would also be appropriate in such settings, to represent the protagonist's struggle against the forces of literally ungodly evil.
In the Warhammer 40k universe, however, religion is actually not that important. Despite the aesthetic trappings, like the giant-robot cathedrals and the Space Marines talking about faith all the time, the setting revolves much, much more around warfare, militarism, and combat—religion is more just a 'flavoring' than any significant part of gameplay, for either the computer or tabletop games. The portrayal of the Imperium as a dysfunctional theocracy is mainly there to make it seem even more dystopian to the player, as most of the (Western, first-world) audience will almost certainly consider religious fanaticism to be undesirable. Thus, the compositional reasoning behind Dawn of War's music makes sense. While genuinely religious music would immerse the player further in Castlevania's setting (emphasizing the holy nature of the protagonist and the aversion to religion vampires have in the classic mythos), it would be more of a distraction in a Warhammer game, which is more about war, war, and more war than any cultural mythos.
Also, I'll admit that I may be comparing apples to oranges here—Castlevania has been around much longer than the Dawn of War series of games. There are two Dawn of War Games (but with several expansions), both of which were first released in the 2000s (though 40k computer games have a much longer history, as old as Castlevania's, the Dawn of War games are the most successful, which is why I chose to focus on them). Thus, the Castlevania games have much more music overall, and it's understandable they'd have more religious music as well, starting from a larger and broader musical base.
So, what can we learn from all this? I suppose it that's you can't necessarily tell what kind of music a given game will have just by looking at its boxcover or artwork. You might expect a game with an armored nun on its cover (like Dawn of War: Soulstorm) to have more religious music than a game with some beefy dude with a whip fighting monsters, but as I've proven above, the opposite is true. Not that I'm knocking either game series, of course, I like both Warhammer and Castlevania—just making a comment on what I found interesting about their music. I hope you found this entry interesting too!
Anyways, next week (or maybe even sooner) I think I'll do a post on another series of games. I'll be discussing the Ys (pronounced eece, like fleece) games, a venerable and very popular series produced by the Falcom company in Japan (The only property that has more games than Ys over there is Final Fantasy!). I bought Ys I and II Chronicles on Steam and really enjoyed them, and I'm gonna start on Ys Origin and Oath in Felghana soon. Please look forward to my posts on them!


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The Pharmacovigilance station follows the Trial Supplies station and precedes the R&D Consultation station. Pharmacovigilance is a legal requirement and is specific for trials within the Clinical Trial Regulations scope. This station is part of the 'trial planning phase' group of stations.
Pharmacovigilance (PV) is the science relating to the detection, assessment, understanding and prevention of the adverse effects of medicines. Systems must be in place to enable the identification, recording, reporting and analysis of safety information so that any safety signals that arise during a trial are quickly identified and acted upon.
For Clinical Trials of Investigational Medicinal Products (CTIMPs), the sponsor's responsibilities for PV are outlined in Part 5 of the Clinical Trial Regulations ) as amended by The Medicines for Human Use (Clinical Trials) (Amendment) (EU Exit) Regulations 2019) . The terminology associated with PV is based on the assessment of seriousness, causality and expectedness of an adverse event. An Adverse Event flowchart (pdf, 180.98 KB) has been developed as part of the Toolkit to provide an overview of the assessments required.
Brexit Transition
The MHRA has published Guidance on Submitting Clinical Trial Safety Reports that describes new reporting routes for both single case reports and Developmental Safety Update Reports/Annual Progress Reports.
The Investigational Site
For all trials, the investigator should make all staff aware of any safety reporting requirements and have systems to ensure all relevant events are detected, recorded and notified in accordance with the protocol (see Safety Reporting station).
Staff should be made aware of these requirements through GCP training and/or knowledge of local procedures or policies.
Further reading & Workstream Documents:
- Safety Reporting station: Outlines the safety reporting requirements once a trial has commenced
- Trial Supplies station: For information on requirements for the Investigators Brochure
- The MHRA Risk-adapted Approaches to the Management of Clinical Trials of Investigational Medicinal Products: Appendix 1, Section 4 - Risk adaptation relating to safety surveillance.


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Goshen, Indiana
Register online by selecting from the classes below. Alternatively, you can also download, print, and mail in your registration form.
Something unique that I want to offer people is the opportunity to come make artwork in a collaborative environment at a time most convenient to one's schedule. Therefore, I am offering classes with multiple days and providing you with the flexibility to choose how often you come each month.
Please keep in mind advance registration is required: at least 24 hours prior to attending any art class. For more information about classes, expecations, and registration, please read the class policies.
Copyright © 2019, Kristen O'Dell. All rights reserved.


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Click on image for details.
Srinivasa R Murthy
Association for the Mentally Challenged, Dharmaram College P.O, Bangalore - 560 029, India
Click here for correspondence address and
Indian psychiatrists have actively engaged with world psychiatry by contributing to understanding and care of persons with mental disorders based on the religious, cultural and social aspects of Indian life. The contributions are significant in the areas of outlining the scope of mental health,classification of mental disorders, understanding the course of mental disorders, psychotherapy, traditional methods of care, role of family in mental health care and care of the mentally ill in the community settings.
Keywords: Indian Psychiatry, global psychiatry, classification, community care, family, religion, yoga, psychotherapy
Correspondence Address:Srinivasa R MurthyAssociation for the Mentally Challenged, Dharmaram College P.O, Bangalore - 560 029 IndiaSource of Support: None, Conflict of Interest: NoneCheck6DOI: 10.4103/0019-5545.69202
Source of Support: None, Conflict of Interest: None


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A friend recently told me about an emergency room visit for a twisted ankle that nearly cost her $3,500 — and how she successfully argued a bill. We're leaving out the name of the hospital and insurer, and also my friend's name; the point here is not to name names but to give helpful advice on challenging a bill.
My friend wrote in an email:
"Below is a draft with the details, that I asked [my wife] to put on her legal stationery, which outlines both what happened and the specific individuals my doctor friend suggested:
Dear [President, Chief Medical officer and Chief Operating Officer of a New York hospital]
I am writing to you today because of a recent visit by [my wife] to [your hospital] on November 4, after she twisted her ankle while hiking nearby.
[My wife] was brought to your emergency room in the early afternoon by ambulance, where a physician's assistant wrapped her leg with an ace bandage, and a nurse gave her Tylenol and sent her home with crutches. While she might have considered having an MRI to see how severe the injury was, she was informed that you did not have an MRI machine. The entire visit lasted about 90 minutes.
So imagine her surprise when she received a bill from her insurance company, showing that [the hospital] had charged $3052.00 for "Op misc. services" and $343.00 for '"doctor services." Attached are the bills she received from [her insurer] for claim numbers [xx] and [xx].
This charge is unconscionable, not only because of the high cost for the most minimal care. In addition, not a single diagnostic study was performed, other than the laying on of hands. It is simply impossible that this amount of care could be considered complex or intensive—and that the charges are in any way 'reasonable and customary'. To charge more than $3000 to view what might have been a sprained ankle is an egregious abuse of the medical system and I would like to request that the appropriate person at the hospital review my request to significantly reduce the fee charged.
If you have further questions, please feel free to contact [my wife] at [phone] or via email at: [email].
Thank you for your consideration,
What happened next
She writes further:
"I was given the name of a patient advocate who was the most helpful contact, since my many years at [former employer] taught me that these types of customer activities are critical for adjudication and perhaps even more pertinent for the hospital given the liability issues they may face in some circumstances.
"Every time the billing department gave me the runaround or failed to call me when planned, I contacted my advocate.
"I can give you more details about all the back and forth if you want, but in the end, I paid $386 to the hospital, about 1/3 of the $300 bill for the physician's assistant who wrapped my leg in an ace bandage, and my insurance covered the ambulance charge (since by then I had met my deductible.). The entire thing was resolved by about April but it did require me calling weekly—and sometimes a few times per week when they hospital was non-responsive."
"Hope that helps; let me know if there's anything else I can do to help."
I asked her a few questions:
1. How much did you pay the patient advocate?
"I didn't pay the advocate anything—he was a hospital employee on a recorded line."
2. This draft letter — is this what [your wife] sent from her law practice, signed by her? And she asked them to contact you, and not her?
"I couldn't find the final letter in my files so I sent what I had on file. [My wife] is a family law attorney and said it was better to have her contacted if she was sending the letter and 'representing' me. Once I sent it and was turned over to an advocate and the billing department, I contacted the hospital myself."
3. I am kind of interested in how you arrived at those numbers.
"They began at $3000, then offered me the 'insurance approved rate' of about $1000, and when I refused (and kept calling) they finally reduced it to $386 which I accepted. The initial rate (billed separately) for the physician's assistant was about $300, and I was billed for 30% which I did not dispute."
The takeAways
4. When we write this kind of piece, we always see if we can give a takeaway for people to learn from your successes.
"What I learned:
"1. My insurance company didn't really care about the cost since when this began, I hadn't met my deductible and they weren't going to pay out anyway. Both they and the hospital tried to convince me that this was customary and the minimum fee for an admission was $3000. Don't believe them.
"2. I think it was important that I knew exactly what care I had received (and my procedures were very simple,) so I could outline what was (and what was not) done. Initially the hospital tried to say that their service was 'appropriate' and I had to remind them that I didn't say the care was inappropriate but the billing for the care received was inappropriate. So pay attention to the argument and refute it specifically.
"3. Be persistent. This took tenacity and was frustrating over several months, but each call was fairly short and once I was assigned a patient advocate, he was always my second call (after calling the billing department and getting little satisfaction.)
"4. Be polite. No matter how frustrating it gets, keep you cool and thank the people talking to you. Be persistent –but cordial. Acknowledge that you know it is not the representative's decision, but that you want to know where to make an appeal or who else you can talk to about the matter."


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Dental care does not only involve fixing teeth, it plays a key role in giving you the perfect smile. Furthermore, they can also give you valuable insight as to why you need to get a certain procedure done.
When it comes to improving your teeth, or smile, in general, it calls for cosmetic dental work. If you are in the UAE, you can have the best dentist in Dubai to take a look at your teeth and help you achieve a million-dollar smile!
Here are the top 5 most common dentistry procedures that are popular are among people:
1. Teeth Bleaching
For those who want to have a quick fix to their stained or yellowed teeth, teeth bleaching is the most popular procedure that people get done. It is for those whose teeth are not much damaged, they just need to be brightened up a little. Teeth bleaching is affordable as well. The process does not take long, and the results are satisfactory as well. People get a bright smile to flaunt.
2. Enamel Abrasion
Another fix to treat teeth discoloration, enamel abrasion involves the usage of pumice in a micro-abrasion machine. It helps in removing the surface stains on the teeth.
Coffee, wine, soda, tea, and tobacco leave stains on the surface of the teeth. Enamel abrasion helps with getting rid of those. However, the procedure is not suitable for intrinsic stains or those present inside the tooth.
The cosmetic dentist you are receiving the treatment form can guide you better as to what stain procedure is going to be most suitable for you.
3. Enamel Bonding
People with chipped teeth or deep, stubborn stains can get dental bonding. The same composite bonding material is used in this procedure that is used in white dental fillings. Your dentist can shape this moldable material into your desired shape so that they match the rest of your teeth and look natural.
However, with the advent of dental veneers, this procedure has taken the back seat. The main reason is the durability of the enamel bonding is shorter.
4. Invisalign Braces
A common misconception is that braces are for kids only. More and more adults are getting braces to make up for what they should have done a long time ago for their teeth. As the name suggests, Invisalign braces work in such a way that no one can know that you are wearing them.
Braces help with treating misalignment that is painful and causes headaches as well. This makes it worth it.
5. Dental Veneers
For decades, dental veneers have been ranking at the top in cosmetic dental procedures. The procedure has become immensely popular. Veneers happen to be thin porcelain shells that fit over the surface of your teeth.
First of all, the enamel of your tooth is filed down gently. Then, the dentist will take its impression. That is then forwarded over to a dental lab for custom veneers. You will be using temporary veneers until you get the permanent ones. Top-rated dentist in Dubai are usually done as a solution for chipped, fractured, or deeply-stained front teeth.
Whether you want to get a fresh-white smile or want to re-do your smile, a reliable and skilled dentist can help you achieve it.


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New Ram 2500 Trucks For Sale in Bedford, Ohio
* The advertised price does not include sales tax, vehicle registration fees, other fees required by law, finance charges and any documentation charges. A negotiable administration fee, up to $115, may be added to the price of the vehicle.
* Images, prices, and options shown, including vehicle color, trim, options, pricing and other specifications are subject to availability, incentive offerings, current pricing and credit worthiness.
Get the Reliable Ram 2500 at Ganley Chrysler Jeep Dodge of Bedford
The Ram 2500 offered at Ganley Chrysler Jeep Dodge of Bedford is a heavy-duty truck designed mainly for hauling and towing services around Bedford. It also offers an upscale cabin with accompanied high-end features. The predicted reliability rating it carries tells more about this work truck. This commercial truck features an affordable price tag making it suitable for those who are budget-oriented.
The new changes it brings along include an increase in its towing capacity and a digital rearview mirror that displays video footage from the rear-facing camera.
Ram 2500 Trim Levels
Ram Tradesman
It is the preliminary trim of the Ram 2500. It boasts some upscale features such as a power-sliding rear window, pedestrian detection, an upgraded infotainment system, and many more.
Ram Big Horn
In addition to what the Tradesman offers, this trim gains automatic climate control, heated front seats and steering wheel, fog lights, and parking sensors (front and rear).
Ram Laramie
This trim carries adaptive cruise control, leather upholstery, park assist (parallel and perpendicular), a height-adjustable driver's seat, and satellite radio. The Laramie is the trim that we highly endorse.
Ram Rebel
This trim boasts plenty of off-road features, such as locking differentials, a firm suspension, and locking differentials. Although it is an off-road trim, it does not come standard with the all-wheel-drive.
Ram Limited
The Ram Limited is one of the top-level trims. It gains heated rear seats, power running boards, and wireless device charging.
Ram Longhorn
Since it is the upper-level trim, it carries all features from the other trims. It only adds a parking camera system and four-corner air suspension.
The Ram 2500 offers two powertrains: a 410 horsepower V-8 engine, and a six-cylinder turbodiesel pumping out 370 horsepower. The base engine is paired with an eight-speed automatic transmission, whereas the turbodiesel receives a bolted six-speed automatic transmission. Both engines offer adequate power in any driving situation.
With the Ram 2500, you are assured of a comfortable drive in rugged areas like in Bedford because of the off-road features it carries, such as high ground clearance and a firm suspension that soaks up the ruggedness of the surface.
This work truck is impressive on winding roads, thanks to its well-composed handling. For towing capabilities, the maximum capacity it can tow is up to 20,000 pounds. This heavy-duty truck records 16 mpg on the gas mileage status when combined, both highway and city.
Interior Features
The interior part of this work truck is equipped with some fabulous components. They are adjustable front seats, cupholders at the front and rear part, cloth headliner, glove box, heated and ventilated front seats, floor covering, adjustable headrests, ambient interior lighting, and much more.
Exterior Features
Its exterior features some upscale components. They are chrome step bumper, fog lights, deep-tinted glass, approach lights, aluminum panels, manual-folding side mirrors with signal indicators, and 18-inch wheels.
Technology & Safety
Infotainment System
Several tech components accompany the infotainment system of this commercial truck, such as satellite radio, Bluetooth connection, automatic climate control, an infotainment touch screen, wireless device charging, USB ports, push-button start, and a navigation system.
Safety Features
The following are the driver assistant features offered by the Ram 2500. They are:
- Parking camera system (surround-view)
- Park assist
- Pedestrian detection
- A head-up display
- Cross-traffic alert
- Automatic emergency braking
Visit Ganley Chrysler Jeep Dodge of Bedford Today!
Feel free to stop Ganley Chrysler Jeep Dodge of Bedford to witness the Ram 2500. We also offer options of buying the truck, such as the online purchase and lease options for our Cleveland customers. Do not hesitate to start the car buying process online.
Schedule A Test Drive
Ken Ganley Chrysler Dodge Jeep Ram Bedford
310 Broadway Ave
Bedford, OH 44146-2131
- Sales: 440-232-2121


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...one of the only haunted houses where the creatures WILL touch you!
(PRWEB) August 13, 2012
Experience a New Location for 2012
The Fear Experience is no stranger to the Cleveland area and it's back again this year with all new thrills and chills! Now located at 10701 Brook Park Road, Parma, Ohio in a building with over 90,000 square feet available to create the most horrifying scenes possible. The Fear Experience is one of the best Cleveland haunted houses and will be open for business in their new location starting September 21 and will be open every Friday and Saturday night during October from 7pm to midnight!
A general admission $15 ticket purchase gains a guest entry into three of the scariest haunted houses in Cleveland, Ohio. All three haunted houses are designed by professionals and the set changes every year! Inside all houses, guests will experience scenery that rivals the best horror movies! Each of these sets contain extreme scenes with all new evils lurking in the shadows, just waiting for the perfect moment to strike. One of the haunted houses is a pitch black maze that guests will have to find their way through, while avoiding the creatures of the dark and hopefully finding the light!
Take a Look at How It All Got Started
The Fear Experience started out as a charity attraction and has since transformed into one of Cleveland's scariest commercial haunted houses, well known by all in the industry. Not only does this haunted house bring to life your greatest fears, but it's also one of the rare gems in the industry where its professional actors can touch its guests, creating the ultimate scare. If customers think they have experienced a real scare before, then they better think again!
The Most Intense Attractions of the Year
One of the unique attractions that The Fear Experience has to offer is the opportunity to be buried alive! Guests will use each of their senses in this thrilling, six feet under attraction! Entry to this attraction is purchased separate from the haunted houses.
Another new feature to The Fear Experience this year is the 7,000 square feet of open space in an old, abandoned department store that will put all guests to the ultimate test: Zombie Paintball! Guests will be able to use a paintball gun to defend themselves through this open area where zombies lurk and wait to attack! Entry to this attraction is purchased separate from the haunted houses.
Also, this great Cleveland, Ohio haunted house will be selling concessions to all guests and there will even be an arcade! There is fun for all ages!
All sets are currently being designed and built. The Fear Experience is also currently hiring actors! If you are interested, please visit http://www.thefearexperience.com or call 216-245-3327 for more information.
Presale tickets can also be purchased at http://www.thefearexperience.com.


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Grow Your Portfolio by Using Short Term Investment Options
If you have a sound amount of money in savings and you are willing to invest this amount to earn profits then the right option for you is to invest in a profitable field. For this purpose, you can park your money in the short term investment options. If you have sound knowledge about investment opportunities then you will get the right returns otherwise there is risk involved in investing your amount. Those that do not have sufficient funds cannot afford to lose their entire amount by investing in a wrong place. You should take guidelines from experts before you invest this amount in different portfolios.
Many options are available for short term money investments but you should be careful while you are investing in these amounts. The small investors always think to use the investment portfolio that is safe for their investment. The main goal of these investment opportunities is to ensure that you will get some interest in return. Do not waste your time and money in investing in portfolios that do not have the best records.
If you have sound knowledge regarding investment opportunities and investing in different portfolios then you do not need to hire services from experts otherwise you should take guidelines from experts. The experts have sound knowledge about the portfolio and investment opportunities. When you have some savings or accumulated funds from your money than before investing this amount you should create a plan first. The goal and planning stage is interlinked with each other so you should invest in options that will give you the best opportunities to save your cost. Selection stage for your investment options is also very critical as you cannot afford to make the wrong decision. The earning capacity of these investment portfolios is also linked with the period you want to keep this money parked.
The short term investment options are the best for small investors as they can earn small earnings by availing these investment options. The brokers usually offer these kinds of investment opportunities. These brokers are very professional in their field and can give you proper guidelines where require. After getting the right information from these experts then you can make your decision whether to invest in these portfolios or you need to search for other opportunities. The small investor is more risk averter than from the other investors due to shortage of funds.


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China's ambassador to Canada is explicitly defending Beijing's position on Hong Kong's pro-democracy protests – even as he presses Ottawa for stronger trade ties to his country.
In one of his first major speeches since taking over the top diplomatic posting earlier this year, Luo Zhaohui on Tuesday pushed back against Canada's support for the demonstrators, suggesting the protests could lead to instability.
"For our deepening economic reform, stability is a must," he told a business audience at a downtown Toronto hotel. "We have to abide by the law."
His words come just weeks ahead of a trade mission to China by Ontario Premier Kathleen Wynne and a visit from Prime Minister Stephen Harper at next month's APEC Summit. Sino-Canadian relations have been tense in recent months, with each side accusing the other of espionage.
Both Ottawa and Queen's Park have backed the Hong Kong protesters, who are demanding the right to elect their local government without interference from Beijing. But Mr. Luo reinforced his government's interpretation of Hong Kong's Basic Law, which allows a "nominating committee" to screen potential candidates.
"I'm quite optimistic the issue will be resolved peacefully," he said, adding later, "Sometimes there are some issues, some problems come up that block bilateral relations, that block the satisfaction of our bilateral relations."
Foreign Minister John Baird stuck to his guns, saying he would not shy away from pressing Beijing on the matter.
"We have raised our concerns with senior members of the Chinese leadership," his spokesman, Adam Hodge, wrote in an e-mail. "Canada has a frank dialogue with the Chinese on a variety of issues, including human rights, rule of law and prosperity."
Ms. Wynne's spokeswoman, Zita Astravas, reiterated the Premier's pledge to tell Chinese officials to allow the protests to continue.
But Mr. Luo made clear the top subject he wants a dialogue on is business. He called for freer trade between the two countries, "bilateral energy corridors" to funnel oil and natural gas to China and for Canadians to invest more in his country. He even asked the assembled business heavyweights to contact him directly if there was anything he could do to help them set up shop.
He also touted a series of internal reforms – which he dubbed a "new deal" – aimed at helping economic development. He said Beijing is delegating power to lower levels of government in the hope that decisions can be made more quickly, lifting restrictions on starting a business and making it easier for people to move from the countryside to the city.
He was particularly candid in discussing the recent loosening of China's one-child policy, which will now allow couples to have two children if one parent is an only child.
"I have one daughter. That is my generation's contribution, sacrifice for my country's economic development," he said. "Personally, I really think that [having] two kids is perfect."
And he told his audience that despite China's rollback from double-digit levels of economic growth in recent years, it will still ultimately overtake the United States to become the world's largest economy.
"The slower economic growth … is a price worthwhile for a more sustainable growth," he said.
Despite the friction on human rights, Ms. Wynne adopted a similarly business-oriented refrain Tuesday. She spent part of the day meeting with Xu Ming, Vice-Governor of Jiangsu province, to discuss co-operation between the two provinces' agriculture sectors.
"We'll build on our past achievements, we'll deepen our ties and hope that will lead to new partnerships that benefit Ontario, Jiangsu and China," she said. "I look forward to a long and mutually prosperous relationship."


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As a misread metaphor, Day of the Dead (Dia de los Muertos) might have been better used for the LA Kings than the Anaheim Ducks as each team used the motif to promote its weekend games. The festival honors and celebrates the dead with "offrendas"—altars decorated to represent the person's life—and eating and drinking in their honor, plus other activities like skull-themed face painting.
The Ducks did their "Dia" on Friday. The Kings did theirs Saturday night. Whose "dead" were more in view—the Ducks', who won their Cup a full dozen years ago and who have only tangential connections in the personnel of now (Ryan Getzlaf)—or the Kings', whose Cups, plural, were as few as five years ago (2012, 2014), the reminders or which, or remainders of which, still skate (or sit on the bench) in the form of Martinez, Doughty, Kopitar, Carter, Toffoli, Lewis, Clifford, and Quick. If I had to pick the more-dead team, well . . . .
The Ducks, further, have made some noise in the early part of the season, surprising people by being "the" California team at a time where everyone had the Sharks in for another run. The Kings were expected to do exactly nothing, the Stanley Cup hangover—don't those generally end a day or two after the party?—holding on, and on, and on into the present.
Truth is, LA has mostly lived down to expectations, starting the season with two wins in seven games, then winning a pair before dropping four in a row and piling up a horrendous -20 goal differential, tied with Detroit for worst in the league and certainly worst in the West. But none of that is a reason to stop going to the games, as was proved in their 4-3 OT win against the Blackhawks at Staples on Saturday evening.
The game started out ominously for Chicago goalie Corey Crawford. After letting in two quick goals, at 2:50 and 4:29, he was pulled. It turns out that he got yanked for concussion protocol and was shortly back in the net. A puck had hit him in the mask.
It might not have been the goals, but the goal scorers—first Kyle Clifford and then relative newbie Matt Roy, neither of whom is there to tally but will take what he gets when offered. But give Clifford credit for roofing a wrister, a beautiful shot no matter who took it, and Roy for getting one through two converging defenders in the slot. It was not unlike a few dozen goals scored over the years by Patrick Kane, but it still looked like Crawford was leaky. It was Clifford's second of the year and Roy's first, and third of his career. He was, by the way, a seventh-round Kings' pick in 2015.
So Crawford went out and Robin Lehner went in, and four minutes later it was 2-1 on a power play goal that started with a scramble and a rebound and ended with Kubalik chipping a shot into the right side of the net with Campbell not able to get over right away.
Campbell followed this up shortly later with a great glove save that caused his whole body to pinwheel dramatically in the aftermath. The crowd cheered. But shortly after, with about three minutes left in P1, he gave the puck away and watched as David Kampf buried it into the open net Campbell had just vacated.
It looked like it was going to be one of those kinds of games, the spectres represented by the skull-motif painted on so many fans' faces in honor of the dead haunting both teams. But it settled down to a back-and-forth game where the Kings kept up the offensive pressure. Shot totals were 17-12, 18-8, and 10-4 in the three periods, all in favor of LA. In the third, the Kings surged ahead on a goal by Michael Amadio before allowing Jonathan Toews to tie it with less than two minutes to go.
The resulting OT could have ended with Alex Nylander took the puck to the LA net with a guy slightly trailing to his right. He should have shot—the spot was there—but he dished. The puck didn't make it to the net.
Drew Doughty, meanwhile, played almost the whole OT for the Kings. They iced the puck at one point, and I looked for signs of fatigue in Doughty, but he was at least faking it right—not all bent over the stick. And he was on the spot to end it, at 4:43. The play had Toffoli assisting. He and Dustin Brown each had two assists on the night.
Doughty sped down the slot, passed to Toffoli, and went around the right side of the net. Toffoli shot. Crawford briefly had it in his pads, but it came loose as Doughty swept around the net and out the left side. He tucked it back in to end the game. Shots in OT were 4-3, again in LA's favor.
Even mascot Bailey had the one side of his face painted calavera-style (look that up on this thing called the "internet"), and he and the 18,230 (minus maybe 4,000 Chicago-sweatered fans) screamed in delight. Their team was alive, if just for this moment.
The Kings gave away a very cool Day of the Dead hat to select patrons, including those who were part of a pre-game party with a live Mariachi band.
The event took place on City View Terrace—aptly named with LA Live and the huge hotel-condo complex to the front and three huge condo projects, now supposedly dormant while half-built, to the right. The weather was in the mid-60s and the air clear. It was one of those nights where LA shines the best.
The Kings now head on the road. Toronto is first, on Tuesday.


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ALLENTOWN — — Nearly 2.2 million Pennsylvania residents work for an employer that does not offer a retirement-savings plan, according to a 2015 Fact Sheet by AARP.
Unless any of them buy the winning Powerball ticket or hit the jackpot under lawmakers' expanded gaming plans, Joe Torsella wants to come up with an alternative to help them make it through to retirement.
"The simple reality is, if you don't have a way of saving at your place, even though theoretically you could walk down the street and set up an account, it just doesn't happen," said Torsella, who is Pennsylvania's treasurer. He visited the Lehigh County Government Center on Thursday to host the first of three hearings statewide for a task force of government and business leaders that he convened to help come up with a retirement solution for those private sector workers.
The task force's goal according to Torsella: Flesh out the dimensions of the problem; catalog workable solutions instituted in other states; and figure out what would work in Pennsylvania.
For those residents who don't have access to employer-sponsored payroll deduction retirement accounts, the state should facilitate individual retirement accounts as a way to get people to start down the path to savings, Torsella said during an interview before the hearing. His office could be a conduit for such accounts.
The Treasury administers the so-called 529 college savings accounts to cover school costs. It also recently debuted "PA ABLE," which are tax-advantage savings accounts for the disabled and their families that do not jeopardize government benefits, he said.
"We're very interested in issues of financial empowerment," said Torsella, who was elected state treasurer last November.
He noted a bipartisan bill for a state-based plan introduced by Sen. Pat Browne, R-Lehigh, and Sen. Art Haywood, D-Montgomery County. In a statement, Browne and Haywood said eligible employees who do not have an employer retirement plan would be automatically enrolled in a statewide private retirement savings plan. Employers would not contribute to these accounts, and those employees who choose not to participate can opt out of the program by notifying their employer.
Pre-tax contributions would begin at $25 a month with no maximum limit on contributions, Torsella added. Workers could be offered the same menu of investment options as the deferred compensation plan offered to state employees, according to the proposed legislation.
Torsella said the House has also introduced similar legislation, authored by Democratic state Reps. Mike Driscoll of Philadelphia and Mike Hanna of Centre and Clinton counties.
Taxpayers wouldn't have to foot the bill if Treasury were to administer a retirement-savings program, he said. He said administration start-up costs for the ABLE program came to less than $1 million, while the 529 college savings plan is paid by fees from participants.
"I think there is a gathering sense that we should look to how we can step in," Torsella said. "We're not talking about state-funded retirement accounts. We're looking at them as models of the 529 college savings plans and ABLE accounts."
Stephen Herzenberg, executive director of the Harrisburg budget watchdog group Keystone Research Center, said Torsella is on the right track, noting the erosion of retirement income stemming from the decline of employer-based defined pension plans and the rise of worker-contribution, employer-sponsored accounts known as 401(k).
"The collapse of retirement security is an important issue," Herzenberg said during a telephone interview.
Torsella also said he hears from many residents about their "economic anxieties."
"I turned 54 about a week ago," he said, "and I realized I could be one of the statistics, with the amount of savings you're supposed to have."
Retirement savings
Hearing in Allentown focuses on retirement help
Business Buzz
Background: Some 2.2 million Pennsylvanians work for an employer that does not offer a retirement plan.
What's happening: State Treasurer Joe Torsella has launched a task force to come up with a possible solution.
Meanwhile, state Sen. Pat Browne, R-Lehigh, is among lawmakers pushing legislation to establish a statewide private retirement savings plan.
Learn more: Visit the Treasury Department online at patreasury.gov.
Get the inside scoop on the Lehigh Valley's business scene on The Business Cycle, themorningcall.com/business. Like us on Facebook: facebook.com/LVBizCycle. Follow us on Twitter: @LVBizCycle.


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PORT OF SPAIN, Trinidad (UPI) — Giorgio Chinaglia headed in a goal in the 51st minute Monday, enabling the North American Soccer League champion New York Cosmos to score a 1-1 tie against a Trinidad All-Star team.
Trinidad took the lead in the 31st minute when Ricky Goddard beat Cosmos goalie Erol Yasin. Chinaglia evened the score on a header off a free kick by Ron Atanasio. It was Chinaglia's eighth goal of the Cosmos' current exhibition tour.
The Cosmos won the first three games of the tour in the Bahamas, outscoring their opposition 31-2. Wednesday the NASL champs play in Trinidad against Nautico of Brazil.


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Posting this here as not sure exactly where this shoud go. I saw on the front page showing FIOS equip. wrong labeling.
FWIW LivingRoom is 7232 DVR Bedroom is 7100. I saw that when I went looking where to post the question as to why my DVR when I go to Support DVR Troubleshooting does it tell me I need to have a DVR STB when I do have one. It also says call 1-800-verizon Opt. 3. There is no option 3. Everything else seems to work ok. But it just makes no sense why there is an option there that makes no real sense.
I am not sure I understand the question. Does your DVR work?
**If someones post has helped you, please acknowledge their assistance by clicking the red thumbs up button to give them Kudos. If you are the original poster and any response gave you your answer, please mark the post that had the answer as the solution**
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Just now saw this reply. The dvr works. But when it acts up and I go to the secion in troubleshooting that says it is supposed to fix common dvr probs. It tells me I need a dvr stb. That makes no sense. And what is this call Vz 1-800-verion opt. 3. There is no option 3. Also my stb's here should show Livingroom 7232 Bedroom 7100..


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Align Collection by BDI – where form and function align.
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They stood over 150 feet high situated by the Hindu Kush mountains for more than 1700 years !
After failing to destroy the 1,700-year-old sandstone statues of Buddha with anti-aircraft and tank fire, the Taliban brought a lorryload of dynamite from Kabul. A Western observer said: "They drilled holes into the torsos of the two statues and then placed dynamite charges inside the holes to blow them up."
The operation to wreck the statues carved into a cliff in the Bamiyan Valley in the Hindu Kush mountains of central Afghanistan was supervised by Mullah Obaidullah, the Taliban defence minister. There has been an international outcry since Mullah Mohammed Omar, the Taliban leader, issued a special edict on Feb 26 2001 ordering the destruction of all non-Islamic statues.
Kofi Annan, the United Nations Secretary-General, had pleaded with the Taliban's foreign minister, Wakil Ahmad Muttawakil, in Islamabad yesterday to save Afghanistan's cultural heritage. He was told that all other "moveable statues" – including more than a dozen smaller Buddha statues in the Kabul Museum – had also been destroyed.
Mr Annan, who spent half an hour with Mullah Wakil during the first leg of his South Asia tour, showed dismay and frustration while talking to reporters. He said: "They will be doing themselves a great deal of disservice and no religious leaders from the Islamic world have supported the edict. I told them you have to respect what is sacred to others.
Mr Annan added that it was "not going to be easier now to raise money" from the international community for the humanitarian crisis unfolding in Afghanistan. More than one million people have been displaced by the fighting and drought. But, no government has told me categorically that they would not help the desperate people of Afghanistan."
Mullah Wakil said the work of destroying the Bamiyan cliff statues had started already, "but they are very tough ones".But his mention of steel rods and cement walls which were erected in the 1930s to bolster the back of the standing Buddhas and which are now exposed made it clear that the frontal part of the statues had been blown up.
Mullah Wakil insisted that the edict was an internal matter for Afghanistan and had been "excessively exagerrated in the outside world and the media". He said the Taliban had no intention to disrespect any other religion. "We do admit the relics were the cultural heritage of Afghanistan, but the part that contradicts our Islamic beliefs we would not like to have them any more."
Mullah Wakil said the edict had been under discussion by the Taliban authorities for more than a year and did not permit the removal of the statues to other countries – which Japan, India and New York's Metropolitan Museum had offered to do. He said the Taliban would rebuild the Kabul Museum to show off the remaining historical objects, which do not represent living things, which are forbidden according to the Taliban's harsh interpretation of Islam.
The destruction of the statues is almost certain to lead to even greater condemnation and the isolation of the Taliban by the international community.


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Sansa Stark is a divisive character for many Game of Thrones fans: Either you feel for her and the unthinkable pain of what she's suffered through over the course of the show, or you still haven't forgiven her for fawning over Joffrey in the early seasons. But whatever sentiments you harbour toward the late Eddard's eldest daughter, there's one seemingly insignificant detail that's worth paying attention to: her hairstyles.
From season to season, Sansa's hair looks have transformed and aligned with her narrative at that moment — and it's not an accident. "It's never random," Sophie Turner, who plays Sansa on the show, previously told Refinery29. "Sansa's hair is constantly reflecting the people she's learning from, or mimicking, or inspired by at the time." Even beyond that, her hairstyles have also had Pinterest-worthy moments, from half-up twists to intricate braids.
Ahead, we've rounded up Sansa's most iconic hair looks from the show's eight seasons, so you can see for yourself how symbolic the styles have been.


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