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Of Hyundai's bespoke electro-centric trio that makes up the compact Ioniq range, the Ioniq Hybrid is the most widely available and least focused of the lot. But that could be to its benefit; as the Ioniq was an early attempt at electrification that has since been surpassed in the EV stakes by all including Hyundai themselves. So the Ioniq Hybrid packs the potential of hybridization but mixed with Hyundai's penchant for reliability, comfort, and impressive economy figures, now dialed up further. It's also vastly cheaper than its two siblings, and with three available trims, there's the versatility of choice. The Ioniq Hybrid is the one to directly rival the Toyota Prius, and with the Blue model's combined 58 mpg estimate it would seem a task all too easy for the Ioniq. With power coming from a 1.6-liter gasoline engine mated to an electric motor, the combined power output rests at 139 horsepower, channeled to the front wheels through a six-speed dual-clutch automatic transmission.
While the Ioniq range as a whole continues from 2018 largely unchanged, minor refinements have been made to the specification and levels of safety equipment for the 2019 model. Google's POI search has been replaced by HERE, Server-based Voice Recognition for improved efficacy. The Hybrid's trim lines have also been updated, with the SEL Tech package amalgamated into the standard SEL offering. The SEL and Limited models now get improved safety features for 2019 in the form of autonomous emergency braking, pedestrian detection, lane keep assist, smart cruise control, and driver attention warning. Additionally, high beam assist is now available in combination with HID headlights on the Limited trim.
See trim levels and configurations:
|Price (MSRP)
|Hybrid Blue
1.6L Inline-4 Hybrid
6-Speed Automatic
Front-Wheel Drive
|Hybrid SEL
1.6L Inline-4 Hybrid
6-Speed Automatic
Front-Wheel Drive
|Plug-In Hybrid
1.6L Inline-4 Plug-in Hybrid
6-Speed Automatic
Front-Wheel Drive
|Hybrid Limited
1.6L Inline-4 Hybrid
6-Speed Automatic
Front-Wheel Drive
While other brands intend for their bespoke hybrid and electric offerings to look alien in an effort to set them apart from the pack, Hyundai's philosophy is more conventional. LED daytime running lights are standard on all models but the base Blue trim, but it's only the Limited trim that upgrades the headlights to HID units. To aid efficiency, all Ioniq Hybrids feature active grille shutters. In Blue and SEL trims, the Ioniq Hybrid rides on 15-inch alloy wheels with differing designs for the two trims. The Limited upgrades to 17-inch alloys in a Limited-specific design.
The base Ioniq Hybrid Blue features gloss black window surrounds and shaped lower doors devoid of cladding, while the SEL gets chrome beltline molding and lower door molding included. Both base editions feature body-colored door handles, while the Limited swaps these out for chrome items. From the SEL trim, the rear lights become LED units. Aside from the change in tail lights, the rear of all three trims remains largely unchanged, though the Blue model gets special badging.
Like its PHEV and Electric siblings, the Ioniq Hybrid measures 176-inches in length and rides on a 106.3-inch wheelbase. It measures 71.7-inches wide - broad for a vehicle in this segment - while standing 56.9-inches tall. Ground clearance is an ample 5.3-inches. Where it differs from its siblings is in its weight, bearing a curb weight of 2,996-3,115 lbs, approximately 400 lbs lighter than the Plug-In and only 100-200 lbs lighter than the pure EV Ioniq variant.
The Ioniq Hybrid is offered with a simple exterior color palette of six colors; Ceramic White, Symphony Air Silver, Summit Gray, Intense Blue, Scarlet Red Pearl, and Black Noir Pearl. All paint options are no-cost extras, with the pick of the bunch being the Intense Blue or Black Noir Pearl.
Each of the three models comprising the Ioniq Hybrid range comes equipped with a 1.6-liter four-cylinder Atkinson cycle gasoline engine and a six-speed dual-clutch automatic transmission. The four-cylinder develops 104 horsepower and 109 lb-ft of torque and is paired with an electric motor supplementing the system with 43 hp and 125 lb-ft of torque. The maximum combined system power output is 139 hp with all power being directed to the front wheels. Hidden beneath the rear passenger seats is a 1.56kWh lithium-ion polymer battery pack that enables electric drive up to speeds of 75 mph under light throttle application.
While the Ioniq Hybrid's economy might be its focus, the drivetrain is infuriating to use effectively. It's primarily the fault of the dual-clutch automatic gearbox which is jerky at low speeds and shifts awkwardly in an attempt to maximize efficiency, but almost always at the wrong moment. The engine itself offers up some decent performance, but throttle inputs are poorly programmed and unless you punch the gas through the firewall, you're going nowhere with any great measure of pace. It feels reluctant to push on, and when you do get frustrated and make more liberal use of the throttle, you compromise economy.
Hyundai could've tuned the system for a bit more of a natural feel, or at least one that feels more usable, particularly around town.
Aside from the tepid performance and frustrating gearbox, the steering is immensely vague and uncommunicative. The system is tuned for accurate weighing, but it feels like in the battle for efficiency, the steering wheel got divorced from the front wheels and lost custody of the kids too - there's just no communication. There's a mushy feeling on-center, with minor inputs yielding no response. On wavering surfaces, the Ioniq deviates from its line and you have to overcorrect constantly because of the lack of response just off-center.
Additionally, the ride is immensely busy, with relatively low weight not compensated for in the suspension tuning. On mirror-smooth surfaces, it responds as naturally as any other vehicle might, but mid-corner bumps negatively affect handling with a bounciness resulting in a porpoising motion that's bound to induce car-sickness on poorer road surfaces. The low-grip tires don't aid handling much either, and the limits of adhesion are low.
The brakes are another particularly low point for the Ioniq Hybrid. Unlike the EV version of the Ioniq, there's almost no energy recuperation off-throttle without brake application, and the blend between regeneration and friction braking is unnatural and severely stepped from one to the next. Heavy braking doesn't feel very confident either, primarily due to the soft suspension resulting in heavy nose-diving that's bound to unsettle most drivers in an emergency.
Every aspect of the drivetrain is geared towards efficiency, with the Ioniq Hybrid's pièce de résistance is the Blue model's EPA estimated economy of a combined 58 mpg, besting even the most efficient of Toyota Priuses at 56 mpg. The SEL and Limited offer marginally lower economy figures, both averaging an estimate of 55 mpg, which is still mighty impressive and enables a range of up to 655 miles on an 11.9-gallon fuel tank, while the Blue model can achieve up to 690 miles with mixed city and highway driving.
Some Hyundai models boast premium interiors, but the Ioniq isn't one of them. Despite feeling solid, the plastics are hard and look cheap, and the standard cloth surfaces feel low rent. But the steering wheel feels superb in hand, and the driver's perch is comfortable and offers standard height adjustment making it easy to find a good driving position. There's the availability of leather and heated front seats too up the trim ladder. The split rear window works to great effect to increase rear visibility, aided by the fact you're unlikely to have rear passengers. That's because the rear of the cabin is immensely cramped, with a poor seating position and sloping roof adults will want to avoid sitting back there at all costs. There are however two full sets of LATCH anchors to affix child safety seats to.
The Hyundai Ioniq Hybrid offers the most cargo volume of the Ioniq family, due to a smaller battery pack giving more space behind the second row of seats. There are 26.5 cubic feet of space back there, which is marginally less than the 27.4 cubic feet the Toyota Prius offers. But the cargo bay is large and the liftback styling gives a wide loading aperture to a square loading area capable of housing five carry-on sized pieces of luggage with some room to spare. Larger items will need to be lifted quite high though, as the hatch opening is rounded substantially at the lower corners which can make loading heavier items a bit awkward. The rear seats fold in a 60/40 split and do fold flat, but space is still limited due to the rear bench being perched high atop the battery pack. The storage is fairly large, but it's shallow, which could pose a problem for some larger items.
The cabin has numerous storage holes, with a large well in front of the gear selector, a narrow console bin and narrow, but wide slot on the dash finding much use. The door pockets can only hold a water bottle though, and the glovebox is on the small side. The rear of the cabin only has two small door pockets and a seatback pocket/net on the back of the front passenger seat.
Standard specification is decent in the Ioniq Hybrid, with features like dual-zone climate control, power windows, tilt-and-telescopic steering, cruise control, keyless entry, and a rearview mirror all standard on all trims. But it's higher in the line-up that you'll find amenities such as power driver seat adjustment, heated seats, and a seven-inch LCD driver display cluster, all available on the SEL. The Limited gets access to the most equipment, with a power sunroof, optional driver seat memory, auto-dimming rearview mirror, and wireless device charging. Driver assistance features are available on the higher trims, including automatic high beams, driver attention warning, blind spot monitoring and automatic emergency braking with pedestrian detection.
Across the Ioniq Hybrid range, standard infotainment is taken care of by a seven-inch infotainment touchscreen with six speakers. The system features AM/FM/SiriusXM satellite radio/HD Radio functionality and accepts inputs via USB, auxiliary and Bluetooth media streaming. Furthermore, the system is fully compatible with Android Auto and Apple CarPlay, which is just as well since navigation is only available as an option on the top trim. Standard on the Limited model is complimentary use of Hyundai's Blue Link Connected Car System. The optional Ultimate Package for the Limited trim upgrades the media system to an eight-inch touchscreen with built-in navigation. The package also equips an Infinity premium audio system with eight speakers, along with Clari-Fi music restoration technology. For those with compatible devices, the package also includes a QI wireless charging pad.
J.D. Power gave the Ioniq Hybrid an overall quality rating of just 70 out of 100, which is the lower boundary for what they define as 'average'. The Toyota Prius is rated above that standard with a score of 74, however, the Prius does have a history of being top of the reliability charts several years down the line.
Hyundai's extensive 10-year/100,000-mile drivetrain warranty from its standard combustion models continues over to the Ioniq Hybrid, while the battery has an unlimited warranty.
To date, there have been two recalls on the Ioniq Hybrid in its current generation, for 2017 and 2018 models. In one incident, an electrical fault results in increased resistance which in turn overheats the battery and the rear seat and potentially leads to fire. The second incident pertains to an oil leak from the clutch actuator that may also lead to a fire. There have been no recalls issued at the time of writing for the 2019 Ioniq Hybrid.
The NHTSA has not tested any of the Hyundai Ioniq range. The Insurance Institute for Highway Safety (IIHS) has, however, awarding the Ioniq Hybrid a 2019 Top Safety Pick with superior frontal crash prevention aids. The standard raft of seven airbags, ABS, EBD, brake assist, stability control, and traction control all apply to the Ioniq, but the notable aspects of its safety-equipment are the standard items on the mid-spec SEL model, which equips smart cruise control, automatic emergency braking, lane keep assist, driver attention warning, blind spot warning, and rear cross-traffic alert as standard from the 2019 model.
Ultra-efficient, impressive styling, and on higher trims at least, loaded with safety features. What's not to like from Hyundai's Ioniq Hybrid? As it turns out, quite a bit, as the interior feels cheap and nasty, and the drive is substandard in many ways, like the awkward suspension and poorly modulated brake feel, and not least of all the poor throttle responses. There are some redeeming factors, such as the technology integration and great safety features available, and the abundance of highly practical cargo volume is a big plus for fans of practicality. This could well have been the best rival to the Toyota Prius, and the base price undercuts that of the Prius by a good margin if you're willing to sacrifice levels of equipment. But the Prius just seems to offer more in just about all areas but price and economy, and you're better off looking at the Toyota - it's just a more complete vehicle in every way.
Hyundai offers the Ioniq Hybrid in three trims, with prices ranging from $22,400 for the Blue model to a base MSRP of $27,800 for the Limited, with the SEL slotting neatly in the middle at $24,950. Prices exclude tax, licensing, registration, and a $920 destination charge, as well as any dealer-specific offers or incentives levied against the Ioniq Hybrid. A range of attractive specials and lease offers are also available.
Hyundai offers the Ioniq Hybrid in three trims: Blue, SEL, and Limited
The Ioniq Hybrid Blue might be the cheapest in price, and it's true that it's also the barest in specification, but it focuses heavily on economy and cuts out the frills in order to beat the Toyota Prius. For the money, you make do without LED taillights or even LED daytime running lights. Inside, you get cloth upholstery with six-way manual adjustment for the driver's and front passenger's seats, dual-zone climate control, cruise control, push-button start, and a seven-inch touchscreen infotainment system with AM/FM/SiriusXM/HD Radio capabilities and Android Auto/Apple CarPlay Functionality. A step up to SEL gets a ten-way power adjustable driver's seat, the front seats are heated, and there's a seven-inch LCD instrument cluster display. Last year's SEL Tech Package has now been integrated as standard, so the SEL also gets automatic emergency braking, smart cruise control, and lane keeping assist, along with driver attention warning, blind spot detection, and rear cross-traffic alert. For comprehensive safety and all the features you really need, the SEL is the pick of the three trims for us. The Limited focuses on upgrades to make the Ioniq a little classier and more refined. To that end, you get 17-inch alloy wheels, HID headlights with automatic high-beam assist, a power tilt-and-slide sunroof, leather seating surfaces, an auto-dimming rearview mirror, and LED interior lighting all standard, but the features don't justify the extra price.
|Price (MSRP)
|Hyundai Ioniq Hybrid
|139 hp
|Toyota Prius
|121 hp
|58/53 mpg
|Honda Insight
|151 hp
|55/49 mpg
The Prius' most direct rival comes in the form of the Hyundai Ioniq, but the Hyundai can't match the standard set by the Toyota. While the Ioniq Hybrid Blue might be marginally more efficient, the Prius drives better, offers better performance, a smoother drive, and more confident handling. It feels more premium inside too but lacks Android Auto and Apple CarPlay, neither of which are catered for in the Prius. The Ioniq may look less offensive, and offer fantastic safety and driver assistance systems, but the Prius is the one you'll want to live with on a day to day basis.
Honda has revived the Insight, now as a stylish, Civic-sized hybrid that receives an abundance of passenger and cargo space the Ioniq can't match. It offers better build quality and a higher class cabin, and while its infotainment system may be clunkier than the Ioniq's, it's a small faux pas in an otherwise stellar package. It's better to drive with greater driver involvement, higher levels of composure, and better performance, and while it can't match the Ioniq's gas mileage, it does feel easier to live with and more enjoyable to pilot. In this instance, the Honda beats the Hyundai by a substantial margin as the better vehicle.
The most popular competitors of 2019 Hyundai Ioniq Hybrid:


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Sad state of affairs, our council is now sending recyclables to landfill. 😥
We need to pick up our recycling game… it's a sign that China really does have the west by the proverbial… recycling isn't the only industry for which we rely on China.
There are some companies that turn soft plastics into park benches and other useful items, surely we can figure out things to do with our other crap.
Of course, it would be nice if manufacturers would use less packaging. Particularly in the realm of fresh produce which seemingly all comes in plastic these days.
As you can see from the post above, this is happening because the recycling centre that would usually handle our recycling waste has gone into receivership. Because we are all so good at recycling these days the value of recycled waste has dropped dramatically and because China is no longer taking our garbage our recycling facilities have nowhere to send what they can't sell. So it is just sitting in massive warehouses.
Of course our council doesn't actually have its own waste facilities, we have "transfer stations" which collect and truck our waste off to other councils to deal with.

subset: commoncrawl


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- Are you facing any problem related to bugs, cockroaches, Deepak (termite), lizard, mosquitoes, (dengue), rats (rodent), or kitchen gardening plant insects attack, etc? Nayakam can help you out. Nayakam has made it easy to get the service of a skilled and reliable service provider.How to avail of such services? The solution is just a click away. Download the Nayakam App from Google Play Store, install it, and select the service of Pest Control you require.
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- Termite treatment
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Platform-based development and large product variety puts high demands on flexibility and adaptability in the assembly systems.
Smart Assembly refers to a next generation capability in assembly systems and technologies which integrate "virtual" and "physical" methods in order to achieve dramatic improvements in productivity, lead-time, quality and agility.
The area contributes to develop new methods and tools that support assembly and design for assembly. Smart Assembly is one of three research themes in Wingquist Laboratory VINN Excellence Centre Stage 3.
Project leader: Kristina Wärmefjord
Balancing of weld-loads reduces throughput time at Volvo Cars
Kristina Wärmefjord, firstname.lastname@example.com
PPD/Product DevelopmentSignals and SystemsFraunhofer Chalmers CentreWingquist LaboratoryGeometry Assurance & Robust DesignGeometry and Motion Planning
Area of AdvanceProduction
Related projectsPlatform Based DevelopmentPerceived Quality
Tolerance Analysis, Robust Design, Assembly/Disassembly, Sequencing, Ergonomics, Resource Allocation, Energy Optimization
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Published: Mon 19 Oct 2015.
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Dive Brief:
- The Office of the Inspector General at HHS announced Tuesday the creation of a new litigation team that will concentrate on identifying and fining Medicare and Medicaid fraud. The team's creation is intended to put further pressure on physicians, drugmakers and other healthcare organizations suspected of bilking the federal government.
- The team was created in March and will have around 10 attorneys when hiring is complete. It will levy primarily civil monetary penalties and concentrate on excluding bad actors from Medicare and Medicaid programs.
- According to Lisa Re, chief of the OIG's administrative and civil remedies branch, the types of cases that will face the most enforcement are those that impact medical judgment—suggesting that physicians will be heavily targeted.
Dive Insight:
The creation of a specific department dedicated to rooting out fraud isn't surprising, given the federal government's ongoing crackdown across Medicare and Medicaid, but this should serve as a warning to providers—especially independent physicians who lack the resources that large organizations have to ensure billing compliance. Docs "need to step up their game on compliance," said OIG veteran Tony Maida (now McDermott Will & Emery).
"What you're going to see are a lot of kickback cases, both against the payor of the kickbacks … and the recipient of the kickbacks, which tend to be physicians," Re said.


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The Climate tipping Points project will be at this September's Winchester Café Scienitifique – details below: Mon 4th September – … More
Category: Uncategorized
Why is Climate Change so Hard to Address? (Article for #SciRoom)
Back in November we held a public discussion with The Science Room, which as part of their mission to get … More
"Why is climate change so hard to address?" #sciroom event on 19/11
This coming Saturday we'll be co-hosting a session of The Science Room – a regular meetup in Southampton where scientists … More
New video! A quick animated guide to Climate Tipping Points
We've just released a quick animated guide to Climate Tipping Points on our YouTube channel – give it a watch … More
Researchers' Café Round-up
We had a great time at Researchers' Café on Friday evening – we hosted two lively discussion circles about Climate … More
Sustainability Researchers' Café on Friday 14th
Our next public event will be at the next Researchers' Café at Mettricks Old Town on Friday 14th October from … More
Getting the ball rolling at the Family Festival of Science
We had a great time at the Family Festival of Science at Thomas Hardye School on Saturday, talking to kids … More
First stall at Family Festival of Science, Saturday 8th October
Our first event will be the Family Festival of Science tomorrow, held at the Thomas Hardye School in Dorchester, Dorset, … More
Welcome to climatetippingpoints.info!
Welcome to climatetippingpoints.info, the online home for the ReCoVER-funded Outreach Project: "The point of no return? An Interactive Stall and … More


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How Does Your Taste in Wine Compare to Megadeth's Dave Mustaine?
Heavy metal fans know Dave Mustaine as the leader of the band Megadeth, but he is now growing a new following in the wine world.
Through is latest venture Mustaine Vineyards, his fans can share his love of wine.
Mustaine spoke to TheStreet's David Marcus about his relationship with wine that started out growing up homeless and drinking "gut rot." But it was a concert with the San Diego symphony that inspired him to launch his own wine.
Mustaine Vineyards is a family business and he says the idea came after he suffered an arm injury that left his guitar playing in jeopardy. The Vineyard is something Mustaine plans to spend even more time on whenever he decides his days in Megadeth are done.
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Racial discrimination against non-citizens (HRC38, 2018, OS)
Date : 2018.07.02
IMADR statement on "Racial discrimination against non-citizens" at the 38th session of the Human Rights Council. Whole text can be read below or downloaded here.
IMADR Oral Statement: 38th session of the Human Rights Council
Item 9: Interactive Dialogue with the Special Rapporteur on racism
2 July 2018
Speaker: Taisuke KOMATSU
Thank you Mr. President,
We welcome the first reports of Ms. Tendayi Achiume as the Special Rapporteur on racism. We express our great appreciation to her close engagement with civil society which she has demonstrated since she took up the function last year.
We endorse her timely recommendations to combat racial discrimination in the context of citizenship, nationality and immigration status, intersecting with gender, religion and other grounds. Women with foreign backgrounds are increasingly becoming a target of manifestations of racial discrimination such as racial profiling, hate speech and hate crimes. In this regard, we would like to stress the vital importance of a comprehensive anti-discrimination law which includes the protection of non-citizens regardless of their immigration status. The absence of or the lack of implementation of such law is one of the common key issues raised by civil society representatives at country reviews of the UN Committee on the Elimination of Racial Discrimination (CERD).
Furthermore, we note with concerns that many States fail to put in place an independent national human rights institution or equality body with the mandate and sufficient resources to combat racial discrimination against vulnerable groups including non-citizens. In this regard, we would like to reiterate the importance of the CERD General recommendation No. 17 on the establishment of national institutions. Strengthening of these legal and institutional measures can also contribute to counter the glorification of Nazism which is addressed in her another report.
We welcome the country visit requests sent by the Special Rapporteur, some of which are pending from the time of her predecessors. We regret that Japan, Malaysia, South Africa and Tunisia have not accepted the request for over 5 years, despite their standing invitation to Special Procedures.
Lastly, we express our commitment to cooperate with the Special Rapporteur to tackle all forms of racial discrimination through strengthening collaboration and cooperation with rights-holders.
We thank you.


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Hattie's first exposure to the construction industry was building forts out of lumber scraps on her dad's jobsites. She eventually graduated to framing walls with her dad on residential projects. Now she is responsible for the creation and submission of proposals, development of marketing materials, and directing and implementing company initiatives. She helps promote our reputation and company culture in the communities where we live and work.
At home, Hattie is surrounding by boys: her husband, two sons, and dog, Virgil, keep things hoppin'. They love floating the Bitterroot River, farmer's markets, and exploring the outdoors. She's a pretty good cook and likes to try new dessert recipes.
Culinary Dislikes: Lima beans


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The USA crypto-currency exchange Coinbase got the rank of a full associate of the Visa product. Right now Coinbase is the only crypto company that has managed to achieve this level of certification.
Principal Member status allows company to issue debit cards, and Coinbase customers can now spend their bitcoins, ethers and XRP wherever Visa cards are accepted.
Coinbase debit card holders will be able to pay with cryptocurrency in 29 European countries. Inside the application, clients can select which wallet to implement for future purchases. The card supports 9 different cryptocurrencies: Bitcoin, Bitcoin Cash, Ethereum, Augur, Litecoin, Brave, XRP, 0x and Stellar.
More important advantage of Principal Member status is that Coinbase has the right to issue debit cards to other companies, including other cryptocurrency companies. Despite the fact that Coinbase is not going to provide such services in the near future, this may become a new source of income for the company, whose revenue for 2019 fell by almost 40%.
Coinbase UK CEO Zeeshan Feroz said in an interview with Forbes that cryptocurrency assets were not liquid before, since it was necessary to convert them into an exchanger, so payments were not instant. Presently, tokens can easily be used in real-time to spend for products together with services, whether or not the retailer takes crypto coins.
Previously, Coinsbase debit cards were dealt with the Paysafe Group Limited. It is expected that ultimately, transaction processing fees will decrease – in the payment chain it will become one link less. Coinbase right now charges a $ 0.99 fee for each operation for below a dollar.
It is noteworthy that earlier the Visa team spoke negatively about cryptocurrency, calling bitcoin "a financial bubble for criminals." The head of the payment giant Mastercard also spoke negatively about cryptocurrencies. In the autumn of 2018, the two firms made the decision to fasten the service terms for bitcoin credit cards.


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Suppose you're looking for the most effective way to sell tickets to an upcoming event. Any event organizer will tell you that offering early bird rates, discount codes, referral codes, and group booking rates is a no-brainer. And they're right – a well-implemented marketing strategy never fails.
But where should you start?
If you're not planning to use an event management solution, you're setting yourself up for a big headache and an organizational nightmare.
Let's explore this in more detail…
Why Should You Use an Events Management Tool?
You might find that WordPress's default features aren't cutting it anymore, primarily if you're featuring events on your site regularly.
Sharing basic information about your events is helpful, but why not take things up a notch? With the right tools, you can sell tickets, track attendance and registrations, and much more.
If this is the sort of thing you're after, you might want to consider a nifty management solution like FooEvents.
Fooevents Review: What's Fooevents?
FooEvents is the #1 ticket plugin for WordPress. With FooEvents, you can sell tickets and manage event registrations for physical and virtual events with ease.
The best bit?
You have full control over your customer data, the sales process, and you can sell unlimited custom tickets without paying ticket fees or commission. It's a win-win. You don't have to be a tech guru to get started; the set-up is quick and straightforward, so rest assured, you'll be up and running in no time.
FooEvents has one main plugin (FooEvents for WooCommerce) plus a range of other plugins for additional functionality. FooEvents offers a range of licenses, all of which are valid for 12 months from the date of purchase.
You can choose from three license types:
Single site license: Here, you or a client can only use each plugin on one domain.
Multiple domains: You can use each plugin on up to three domains.
Unlimited Domains: You can use each plugin on unlimited web domains.
FooEvents also enables you to buy individual plugins or a bundle, depending on your needs. Pricing starts at $59 for the main FooEvents for WooCommerce plugin and the bundles range between $129 to $389 depending on the license type. If you're not happy with your purchase, FooEvents offers a seven-day money-back guarantee.
Fooevents Review: Fooevents – Its Key Features
Each Fooevents bundle comes with a range of different features. There are three available bundles:
- The basic bundle
- The bookings bundle
- The premium bundle
When you select your preferred bundle, you can choose either a single, multiple, or unlimited site license. Let's look at each of these bundles in turn:
The Basic Bundle: You can display your events on a calendar, check-in attendees using a barcode scanner, email tickets as a PDF document, and allow attendees to download tickets from their account.
The Bookings Bundle: Here, you can create bookable products and recurring events, display slots and dates for customers to select, check-in attendees, and manage bookings with the FooEvents check-in app.
The Premium Bundle: This bundle allows you to ask custom questions to each attendee, set events that occur more than once a day, and empower customers to choose specific seats.
You're in Control
You can choose precisely what your tickets look like, how they're sent, their format, and how they're used. All tickets contain 1D or QR barcodes, too (if you want them); otherwise, you can disable this via your settings.
If you're not the creative type, you can always use FooEvents's ticket templates. With over 20 professionally designed templates to choose from, you're sure to find a suitable layout for you.
Tickets Are Printer Friendly
PDF tickets are easy to print, and attendees can print them from any device that supports PDFs.
A Zoom Integration
You can sell tickets to webinars, online conferences, and meetings hosted on Zoom. FooEvents connects securely to your Zoom account, where you can automatically pre-register attendees, providing a hassle-free experience for both you and your guests.
Grow Your Database
Once your attendees have been issued tickets, they're registered in your WooCommerce database. This is excellent news if you want to build a CRM database and manage access.
Manage Access With the Free Check-Ins App
The era of the clipboard is over. Now, all your attendees, events, and booking information are accessible from one centralized place. If you're dealing with vast numbers of attendees, this is a winner. The app connects securely to your WordPress website and allows you to scan tickets instantly with its built-in barcode scanner.
100% Self Service
Customers can check availability on your website and book their preferred time and date slots. This means no phone calls, no emails; attendees can handle everything themselves, from one place with just a click.
Seating Charts
If you download the FooEvents seating extension, you can create and manage seating charts. Attendees can view booked seats and select their own from the ones available.
Access Over 100 Secure Payment Methods
You can sell tickets and process payments using various payment methods, including credit cards, bank transfers, cash on delivery, and PayPal.
Fooevents Review: How Do I Set Up Fooevents?
This is a quick rundown of how the app works:
- Purchase your license: Have a look at the license types on offer and choose the best one for you.
- Download the plugin: Once you've purchased a license, FooEvents sends you an order confirmation email. Open this to access the direct download links to your plugin files. If you can't access these through your email, you can also download them from the 'My Account' section of the FooEvents website.
- Install the plugin: Head to your WordPress admin area, then select 'plugins' and 'add new.' Here, you can upload the zip file you downloaded from your order confirmation email or the 'My Account' section of the website.
- Activation: You should now see your plugin under the 'plugins' tab of your WordPress admin area. Hit 'activate,' and you're good to go.
- Activate automatic updates: If you want to benefit from automatic updates, you'll need to link your account to your website. To do this, enter your website URL in the license tab. You can find this under the 'My Account' section. FooEvents will then provide you with a license key to enter.
Voila, that's it!
Fooevents Review: What About Fooevents' Competitors?
Although there are cheaper ticket management solutions on the market, many like to hit you with additional one-time fees that can burn a hole in your pocket. In contrast, FooEvents doesn't do this, and their bundles come with free features like an iOS and Android app to manage check-ins.
They also have one of the most extensive feature lists on the market. You're spoilt for choice with features like coupon support, ticket inventory, email ticket themes, branded tickets, and an export attendee CSV list. However, FooEvents is only compatible with WooCommerce WordPress websites. So, if you're using a different website platform, you'll need to look elsewhere. If you fall into this category, here a couple of other options worth considering:
Tickera: Tickera offers similar features to FooEvents, and it's not limited to WooCommerce WordPress. Tickera payment plans start from $49 per year, plus a $70 one-time fee.
Events Tickets Plus: This plugin allows you to sell tickets on multiple websites. It comes with many of the same features as Tickera and FooEvents. You can manage ticketing and RSVPs for free with the basic plan, or you can upgrade to unlock more advanced features. Prices range from $99 for one-site programs, but you could pay as much as $750 for unlimited site plans.
Fooevents Review: FAQ's
Last but not least, let's round off this review with some of the frequently asked questions we hear about FooEvents:
Q: How do I create an event?
A: Go to your WordPress admin area, select 'products' and then 'add new.' You can choose the title of your event and add information such as a description and images. In your WooCommerce product data settings, you'll find the FooEvents event tab. Here you'll see various fields you can use to configure your event and your ticket. You can also create different ticket types (such as VIP, student, etc.) using WooCommerce 'attributes and variations'.
Q: Can I translate FooEvents?
A: Use WordPress translation files (.PO/.MO) to change all FooEvents text outputs into your website's default language. FooEvents is also compatible with WordPress Multilingual (WPML), meaning you can translate your event content into different languages.
Q: Can I create my own PDF or HTML ticket themes?
A: Yes, you can. Check out the following instructions for a more detailed explanation.
Q: Which FooEvents product is the best fit for me?
A: Each FooEvents product comes with different features. The bundle you choose will depend on the size of your event and the functionality you need. Check out the other pricing bundles above and see which features best suit your requirements and budget.
Q: What payment gateways does FooEvents support?
A: Payments are processed using WooCommerce which means you can choose from over 100 popular payment gateways, including Stripe, Square, PayPal, most credit cards, direct bank transfer or cash on delivery.
Q: Can I change the design and layout?
A: FooEvents works seamlessly with the majority of WooCommerce compatible themes, meaning you have countless options to choose from when setting up your store and marketing your events to customers. The event page uses WooCommerce templates which makes it easy to customize and make your own.
Fooevents Review: Are You Ready to Use Fooevents?
We hope that by the end of this Fooevents review, you now have a better idea of whether the app is a good choice for your business. If you're still on the fence, why not give their seven-day moneyback guarantee a spin?
Whatever you decide, tell us all about it in the comments box below. Speak soon!


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Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats
The main objective of wound treatments is to restore the functional skin properties and prevent infection. Traditional Chinese medicine provides alternative anti-inflammatory, antimicrobial, and wound healing therapies. Both Angelica dahurica extract (AE) and Rheum officinale extract (RE) possess antimicrobial activity. In this study, AE and RE were applied in wound treatment to investigate their healing effects. Thirty Sprague-Dawley rats with dorsal full-thickness skin excision were divided into normal saline (NS), AE, RE, AE plus RE (ARE), and Biomycin (BM) groups. The treatment and area measurement of wounds were applied daily for 21 days. Wound biopsies and blood samples were obtained for histology examinations and cytokine analysis. Results showed that wound contraction in ARE group was significantly higher than that in NS and BM groups (P < 0.05). Histological analysis showed that more inflammatory cell infiltration, collagen fibers, and myofibroblasts were observed in ARE treated group than those in NS group on days 3–5. In ARE group, plasma IL-6 levels were elevated during days 3–5 (P > 0.05), and plasma TGF-β1 levels were significantly lower than those in the NS group on days 3-4 (P < 0.05). In conclusion, ARE accelerates wound healing during inflammation and proliferation phases.
1. Introduction
The skin, the largest organ of the body, forms an indispensable barrier that protects against injury and infection [1]. When injury occurs, a complex cascade of biological processes begins to repair and regenerate the damaged tissue. The wound healing process comprises four continuous and overlapping phases: hemostasis, inflammation, proliferation, and remodeling [2]. In general, the goals of wound care and treatment are to prevent infection, reduce swelling and inflammation, accelerate wound healing, and minimize scar formation [3]. Antimicrobial agents such as ciprofloxacin, mupirocin, and neomycin sulfate are commonly used to prevent and treat infections [4], while corticosteroids and nonsteroidal anti-inflammatory drugs are used to reduce swelling and inflammation of the skin [5]. Some supplements, such as vitamin E, glutamine, zinc, and freshwater clam extract, have also been shown to be effective in wound healing [6, 7].
In recent years, traditional Chinese medicine (TCM) and natural compounds obtained from a variety of herbs have become popular as alternative and complementary therapies [8]. Moreover, numerous studies have demonstrated the effectiveness of extracts from plants such as Aloe vera, Calendula officinalis, Abrus cantoniensis, and Ampelopsis japonica in treating skin lesions [9–11]. Compared with the common use of therapies, such as antimicrobial agents and anti-inflammatory drugs, the advantage of using TCM therapy for skin lesions is that it may have multiple active effects, such as anti-inflammatory activity, antimicrobial activity, cell stimulation, and the promotion of wound healing [9]. This study therefore investigated the treatment of skin wounds with TCM extracts. Rheum officinale (da huang) and Angelica dahurica (bai zhi), which have heat-clearing, toxin-resolving, swelling reduction, anti-inflammatory, antimicrobial, and antibacterial properties, were chosen for the wound treatment [12–18]. Emodin, an active compound in R. officinale, has been shown to improve wound healing in rats [19]. Furthermore, A. dahurica extract has been demonstrated to accelerate the proliferation of rat skin cells and human keratinocytes in vitro [20, 21]. However, using A. dahurica or/and R. officinale on treating wound has not been studied yet. In this study, an excisional wound rat model was exploited using extracts prepared from these two herbs to investigate their effects on wound healing.
2. Materials and Methods
2.1. Preparation of the TCM Extracts
A. dahurica and R. officinale powders were purchased from Hou-Chuia Biopharm Co., Ltd. Tainan City, Taiwan. Ethanol extracts of these TCMs were prepared separately by adding 50 g of the powders into 400 mL of 70% ethanol and heating the mixtures at 70°C for 24 h. The mixtures were then centrifuged at 10,000 ×g for 15 min and the supernatants were concentrated under reduced pressure to remove the ethanol. Equal volumes of A. dahurica extract (AE) and R. officinale extract (RE) were mixed and designated as ARE. The AE, RE, and ARE were sterilized by autoclave before application.
2.2. Antimicrobial Susceptibility Test of the TCM Extracts
Disk diffusion test was performed according to CLSI standards [22] to test the antimicrobial susceptibility of AE, RE, and ARE. S. aureus ATCC 29213 (Bioresource Collection and Research Center, BCRC, Hsinchu, Taiwan) was cultured in Tryptic Soy Broth (Becton, Dickinson and Company, USA) at 37°C until log phase and the turbidity was adjusted with the broth to achieve 0.5 McFarland standard (approximately 108 CFU/mL). The autoclaved 6 mm diameter filter paper disks (Advantec Grade Number 1) were soaked with 20 μL of AE, RE, or ARE and dried at room temperature. The inoculums (~107 cells) were spread onto Mueller-Hinton agar (Becton, Dickinson and Company, USA), and then the disks were placed onto the agar. Disks containing distilled water were used as negative control (Blank). The results were expressed as the means ± SE of diameters (mm) of the inhibition zone scored after overnight incubation.
2.3. Anti-Inflammatory Test of the TCM Extracts
Human acute monocytic leukemia (THP-1) cells (BCRC, Hsinchu, Taiwan) were cultured in RPMI-1640 medium (Gibco BRL, Gaithersburg, MD, USA) supplemented with 0.05 mM β-mercaptoethanol (Sigma-Aldrich, St. Louis, MO, USA), 2 g/L sodium bicarbonate, 1% penicillin/streptomycin (PS, Biological Industries, Beithemeek, Israel), and 10% fetal bovine serum (Gibco BRL, Gaithersburg, MD, USA) in a humidified atmosphere with 5% CO2 at 37°C. For anti-inflammatory test, THP-1 cells were seeded into 24-well culture plates at 1 × 105 cells/mL/well, and then 1 μg/mL lipopolysaccharides (LPS) (Sigma-Aldrich, St. Louis, MO, USA) were added to the wells to induce inflammation. The TCM extracts, AE, RE, or ARE (final concentration = 0.2%), were then added to the wells. After 24 h of coincubation, the supernatants were obtained by centrifuged at 15,000 ×g for 15 min and assayed using human TNF-α enzyme-linked immunosorbent assay (ELISA) kits (R&D System, MN, USA).
2.4. Animals
Thirty healthy male Sprague-Dawley (SD) rats weighing between 250 and 300 g were used in this study. The rats were placed in standard cages and housed in a humidity- and temperature-controlled room (55 ± 15%; 22 ± 1°C) with 12-h light-dark cycles. All the rats received standard amounts of food and water. All experiments were performed according to the institutional protocols of the Animal Usage Regulation Committee of Tzu Chi University (number 104084).
2.5. Excisional Wound Model and Treatment
The rats were anesthetized through ether inhalation for approximately 10 minutes, following which the back hair of the rats was shaved and a full-thickness excisional skin wound (area of 20 × 10 mm2, depth of 2 mm) was created on the dorsum of each rat by using forceps and scissors under sterile conditions [7]. After wounding, the rats were housed individually in clean cages and randomly classified into five groups: normal saline (NS), AE, RE, ARE, and Biomycin (BM). Treatments were administered once a day for 21 days. Wounds were cleaned gently with sterile NS swabs before treatment. In the NS group, no other treatment was provided after NS cleaning. In the AE, RE, and ARE groups, treatment involved the topical application of approximately 1 μL/mm2 of TCM extract. The TCM extracts were kept on the wound. In the BM group, a thin layer of Biomycin ointment (CBC Biotechnological & Pharmaceutical Co., Ltd. New Taipei City, Taiwan) was administered using sterile swabs. After treatment, the wounds were left at air without covered, and the rats were housed individually in clean cages. The rats were sacrificed on days 3, 4, 5, and 21 after wounding, and wound biopsies and blood samples were obtained for analysis.
2.6. Wound Measurement
The wounds and a ruler with 1-mm increments placed beside the wounds were photographed with a digital camera (Nikon D70, Tokyo, Japan) once a day before treatment. The wound areas were measured using ImageJ (National Institutes of Health, United States). Percentage of wound area after contraction was calculated as follows: (, the proportion of wound area on day 0; , the proportion of remaining wound area on day ).
2.7. Histology Analysis
Cross-sectional full-thickness skin biopsies were obtained from the wound sites at days 3, 4, 5, and 21 after wounding for histological study. These wound samples were fixed with 4% buffered formaldehyde, embedded in paraffin, and divided into 5-µm sections. The tissue sections were stained with hematoxylin and eosin (H&E) for general morphology and Masson's trichrome for collagen fibers observation. Immunohistochemistry (IHC) was performed using alpha-smooth muscle actin (α-SMA) antibodies for myofibroblasts observation. The tissue sections were deparaffinized, rehydrated, and treated with peroxidase reagent for 20 min at room temperature. The sections were then boiled with the citrate buffer (pH 6.0) for 30 min and blocked with the ImmunoBlock for 2 h at room temperature. After washing with PBS, the tissue sections were incubated with α-SMA antibodies (1 : 200 dilution; Abcam, Cambridge, MA, USA) for 3 h and then treated with mouse probe HRP labeling (BioTnA Inc., Kaohsiung, Taiwan) for 30 min at room temperature. The sections were stained with DAB brown (1 : 50 dilution; BioTnA) and counterstained with hematoxylin. After dehydration, sections on slides were covered with coverslips, and the results were analyzed using microscope.
2.8. Analysis of Cytokines
Blood samples were collected at days 3, 4, and 5 after wounding and centrifuged at 3000 ×g for 10 min at 4°C. The plasma samples were stored at −20°C for later measurement of cytokine concentration. The levels of inflammatory cytokine IL-6 and the angiogenesis factor TGF-β1 were measured using rat IL-6 and TGF-β1 ELISA kits (R&D Systems, MN, USA). Measurements were performed according to the manufacturer instructions. The optical density of each reaction was determined using a Dynex MRX II microplate reader (Chantilly, VA, USA) at 450 nm and converted into a concentration through the standard curve. The results were expressed as pg/mL.
2.9. Statistical Analysis
All values were expressed as mean ± standard error of the mean. Statistical analyses were performed through a -test with IBM® SPSS® Statistics (version 22.0, SPSS Inc., IBM, Chicago, IL, USA). values < 0.05 were considered statistically significant.
3. Results
3.1. Antimicrobial and Anti-Inflammatory Effects of AE and RE
All of the AE, RE, and ARE have showed the antimicrobial activity against S. aureus ATCC 29213 (Table 1). Furthermore, AE, RE, and ARE reduced the expression of TNF-α released by LPS-stimulated THP-1 cells, indicating the anti-inflammatory effects of the TCM extracts (Figure 1). These results revealed that these TCM extracts have antimicrobial and anti-inflammatory activities.
3.2. Effects of AE and RE on Wound Contraction
The AE, RE, and ARE were topical application on the wound site for treatment. The percentage of wound area after contraction represented the effects of each treatment on wound healing. Figure 2(a) shows the photographs of wound sites on days 0, 3, 4, 5, 7, 10, 14, and 21 after wounding; Figure 2(b) shows the percentage of wound area after contraction measured using ImageJ from days 0 to 21. On days 3–10, the percentage of wound contraction in the ARE group was significantly lower than that in the NS group (Figure 2). The percentage of wound area after contraction in the ARE group was lower than that in the NS group on day 3 (70.25% versus 80.63%), day 4 (60.05% versus 76.41%), day 5 (55.16% versus 74.80%), day 7 (41.23% versus 52.61%), day 10 (19.52% versus 27.67%), and day 14 (12.23% versus 7.07%) (P < 0.05). On day 21, the wounds had nearly recovered. The wound areas of the ARE and NS group remained at 0.05% and 0.78%, respectively, and the percentages of wound contraction in the AE and RE groups did not differ significantly from that in the NS group (Figure 2(b)). However, the wound contraction of the BM group was less favorable than those of the other groups (Figure 2(b)). The histological characterization of the wound sites on day 21 showed almost complete healing on NS, AE, RE, and ARE groups, while scabs were still observed above the epidermis on the BM group.
3.3. Histological Observation of Healed Wound Area
Skin biopsies from the wound sites on days 3–5 were investigated to determine the treatment effectiveness. The histological observations showed that scabs and granulation tissues were observed at the wound sites, and more inflammatory cells were observed in ARE groups than NS group on days 3–5 (Figure 3). On day 3, H&E stain showed that the scabs in ARE group were thicker than those in NS group, and the dermis was loose in NS group while an organized formation in the dermis was observed in ARE group. Masson's trichrome stain showed that newly formed collagen fibers were observed in the dermis, and the presence of collagen fibers in ARE group was more than those in NS group (Figure 3). On day 4, the dermis in NS group was still loose, and the granulation tissues in ARE group were more than those in NS group. On day 5, the scabs in ARE group were thinner than those in NS group, and more myofibroblasts were observed in ARE group than NS group as shown in IHC of α-SMA (Figure 3). The histological characterization on day 21 of NS and ARE groups showed that new epidermis was constructed; hair follicles and dense irregular connective tissue were observed in dermis from H&E stain. In both groups, abundant and well-organized collagen were present in the dermis as shown in Masson's trichrome stain; myofibroblasts were absent in the dermis as shown in IHC of α-SMA. After 21 days of wound healing process, the wounds were almost healed and formed a complete structure of normal skin (Figure 3).
3.4. IL-6 and TGF-β1 Levels on Day 3 to Day 5
The levels of inflammatory cytokine IL-6 and the angiogenesis factor TGF-β1 at days 3–5 were measured to investigate treatment effectiveness. Figure 4(a) showed elevation in the plasma IL-6 levels of the ARE group (18.38 pg/mL at day 3; 26.08 pg/mL at day 4; 23.38 pg/mL at day 5) exceeding that in the NS group (10.88 pg/mL at day 3; 24.42 pg/mL at day 4; 13.58 pg/mL at day 5) (). The plasma TGF-β1 levels of the ARE group were significantly lower than those in the NS group on days 3 and 4 (Figure 4(b)). On day 3, the TGF-β1 levels in NS and ARE groups were 79.52 pg/mL and 36.24 pg/mL (P < 0.05), respectively, and 46.89 pg/mL and 33.47 pg/mL (P < 0.05) on day 4.
4. Discussion
The TCM extracts, AE, RE, and ARE were used on excisional wound treatment because these extracts have antimicrobial and anti-inflammatory activities (Table 1, Figure 1). Our data revealed that treatment with ARE accelerated the healing of excisional wounds in the early stage of the wound healing process. The wound healing process consists of four continuous and overlapping phases. The hemostasis phase starts immediately after injury, followed by the inflammation phase, which continues for approximately 10 days. Meanwhile, the proliferative phase starts on the third day after wounding and continues for approximately 2 weeks. Remodeling and scar maturation starts during the proliferative phase and continues for several months [2]. In our data, the wound contraction rate of the ARE group was significantly higher than that of the control group on days 3–10 (Figure 2). Since day 3 to day 10 fall in the inflammation and proliferation phases, these results therefore suggest that the wound healing effect of ARE occurred within these phases.
Because the wound contraction of the ARE group was significantly lower than that of the NS group on days 3–5, we investigated histological changes in the wound healing process during this period. Collagen fibers play key components in wound healing, which provide structural support of skin strength [2]. Myofibroblasts are crucial cells involved in wound healing, which present more in the granulation tissue and disappeared after wound repair [23]. In our data, the histological observation revealed more collagen fibers and more myofibroblasts were present in ARE group than in NS group (Figure 3), suggesting that ARE treatment increases collagen fibers and myofibroblasts in the inflammation phase of wound healing process. The inflammatory cells, such as neutrophils and monocytes, are recruited to the wound site after injury [24]. Our histological characterization revealed that infiltration of inflammatory cell was more in ARE treated group than in NS group, suggesting ARE treatment increases inflammatory cell infiltration at the wound site during the inflammation phase.
The levels of inflammatory cytokine IL-6 and the angiogenesis factor TGF-β1 at days 3–5 were measured to investigate treatment effectiveness. Several studies have reported that IL-6 plays an influential role in wound healing. Kuhn et al. found that IL-6 is necessary for the efficient stimulation of epithelial proliferation after injury [25], while Lin et al. demonstrated that IL-6 knockout mice had impaired wound healing and suggested that IL-6 has crucial roles in wound healing, probably by regulating leukocyte infiltration, angiogenesis, and collagen accumulation [26]. Our results showed that the plasma IL-6 levels in the ARE group increased from day 3 to day 5 (Figure 4(a)), suggesting that wound contraction improved greatly in the ARE group during this period, possibly because of the increase in amount of IL-6. TGF-β1 reportedly plays an intricate role in modulating inflammation and immunity. Ashcroft et al. found that mice lacking Smad3, proteins that transduce signals from TGF-β1, exhibited accelerated wound healing and reduced inflammatory responses compared with those who had the proteins [27]. Li et al. found that overexpression of TGF-β1 in keratinocytes, a predominant cell type in the epidermis, causes chronic inflammation and delays wound healing [28]. However, Tang et al. reported that TGF-β1 mRNA expression was increased in emodin treatment group in wound tissue on day 7 [19]. We supposed that the opposite results of TGF-β1 were because these experiments were carried out on different days in wound healing process. The period of days 3-4 is involved in the inflammatory phase, while day 7 is involved in the proliferation phase [2]. Our data revealed that the plasma TGF-β1 levels of the ARE group were significantly lower than those in the NS group on days 3 and 4 (Figure 4(b)), indicating the lower levels of TGF-β1 accelerated wound healing process of inflammatory stage.
In AE, the active compound, furanocoumarins, possessed anti-inflammatory effect in the LPS-stimulated RAW264.7 macrophage cells [29]. Imperatorin, another active compound in AE, showed antioxidant effect protected renal injury by reducing NADPH oxidase and inhibiting of MAPK pathway [30]. AE can accelerate the proliferation of human keratinocytes and stimulate the cell cycle process of human keratinocytes by downregulation of cyclin D1 expression, thus enhancing the wound healing process [20]. In RE, the active compound, emodin, possessed anti-inflammatory activity via inhibiting the NF-κB and MAPK signaling pathway [31], had antimicrobial effect against S. aureus [32], and enhanced wound healing in rats [19]. Rhein, another active compound found in RE, possessed antimicrobial effect against S. aureus [32] and protected endothelial cells against oxidative injury [33]. The antibacterial, anti-inflammatory, and antioxidant properties were related to the improvement of wound healing [34], suggesting that the effects of wound healing by ARE treatment may be attributed to the antibacterial, anti-inflammatory, and antioxidant activities in ARE. Comparing to a previous study in wound healing with emodin [19], our ARE treatment is much more effective on wound contraction, suggesting that, in addition to emodin, other active constituents, such as furanocoumarins, imperatorin, and rhein in ARE, may have contributed to the wound healing effects. Furthermore, our results showed that the healing effectiveness observed in ARE treated group was better than those in AE- or RE-treated groups, suggesting the synergistic effects of ARE on wound healing.
5. Conclusion
In this study, we demonstrated that ARE accelerates wound healing during the inflammation and proliferation phases. The present study suggests that ARE may be useful for application in wound treatment in the early stage of wound healing. We propose that ARE may have multiple effects in the treatment of skin lesions, including anti-inflammatory activity, antimicrobial activity, cell stimulation properties, and the promotion of wound healing.
Conflicts of Interest
The authors declare that there are no conflicts of interest regarding the publication of this article.
This study was supported, in part, by grants from the Tzu Chi University (TCMRC-P-105003). The authors thank ENCH biotechnology company for assistance in preparing the ARE.
R. F. Pereira, C. C. Barrias, P. L. Granja, and P. J. Bartolo, "Advanced biofabrication strategies for skin regeneration and repair," Nanomedicine, vol. 8, no. 4, pp. 603–621, 2013.View at: Publisher Site | Google Scholar
S. Enoch and D. J. Leaper, "Basic science of wound healing," Surgery (Oxford), vol. 23, no. 2, pp. 37–42, 2005.View at: Publisher Site | Google Scholar
M. P. Rowan, L. C. Cancio, E. A. Elster et al., "Burn wound healing and treatment: review and advancements," Critical Care, vol. 19, no. 1, article 243, 2015.View at: Publisher Site | Google Scholar
S. O'Meara, N. Cullum, M. Majid, and T. Sheldon, "Systematic reviews of wound care management: (3) Antimicrobial agents for chronic wounds; (4) diabetic foot ulceration," Health Technology Assessment, vol. 4, no. 21, p. -228, 2000.View at: Google Scholar
C.-S. Chen, W.-H. Su, M.-H. Cheng et al., "Nonsteroidal anti-inflammatory drugs for wounds: pain relief or excessive scar formation?" Mediators of Inflammation, vol. 2010, Article ID 413238, 2010.View at: Publisher Site | Google Scholar
S. Guo and L. A. DiPietro, "Critical review in oral biology & medicine: factors affecting wound healing," Journal of Dental Research, vol. 89, no. 3, pp. 219–229, 2010.View at: Publisher Site | Google Scholar
Y.-C. Peng, F.-L. Yang, Y.-M. Subeq, C.-C. Tien, and R.-P. Lee, "Freshwater clam extract supplementation improves wound healing by decreasing the tumor necrosis factor α level in blood," Journal of the Science of Food and Agriculture, vol. 97, no. 4, pp. 1193–1199, 2017.View at: Publisher Site | Google Scholar
S. Bent, "Herbal medicine in the united states: review of efficacy, safety, and regulation: grand rounds at university of California, san francisco medical center," Journal of General Internal Medicine, vol. 23, no. 6, pp. 854–859, 2008.View at: Publisher Site | Google Scholar
R. F. Pereira and P. J. Bártolo, "Traditional therapies for skin wound healing," Advances in Wound Care, vol. 5, no. 5, pp. 208–229, 2016.View at: Publisher Site | Google Scholar
Q. Zeng, H. Xie, H. Song et al., "In vivo wound healing activity of Abrus cantoniensis extract," Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 6568528, pp. 1–7, 2016.View at: Publisher Site | Google Scholar
K. Lee, B. Lee, M.-H. Lee et al., "Effect of ampelopsis radix on wound healing in scalded rats," BMC Complementary and Alternative Medicine, vol. 15, no. 1, article 213, 2015.View at: Publisher Site | Google Scholar
B. S. F. Bazzaz, M. Khajehkaramadin, and H. R. Shokooheizadeh, "In vitro antibacterial activity of Rheum ribes extract obtained from various plant parts against clinical isolates of Gram-negative pathogens," Iranian Journal of Pharmaceutical Research, vol. 2005, no. 2, pp. 87–91, 2005.View at: Google Scholar
W. Yanwen, G. Wenyuan, X. Xiaohe, and L. Yi, "Calorimetric investigation of the effect of hydroxyanthraquinones in Rheum officinale baill on Staphylococcus aureus growth," Thermochimica Acta, vol. 429, no. 2, pp. 167–170, 2005.View at: Publisher Site | Google Scholar
B. Hu, H. Zhang, X. Meng, F. Wang, and P. Wang, "Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide- induced inflammatory responses in RAW264.7 macrophages," Journal of Ethnopharmacology, vol. 153, no. 3, pp. 846–853, 2014.View at: Publisher Site | Google Scholar
C.-Y. Hsiang, C.-L. Hsieh, S.-L. Wu, L. Lu, T.-Y. Lai, and Ho, "Inhibitory effect of anti-pyretic and anti-inflammatory herbs on herpes simplex virus replication," American Journal of Chinese Medicine, vol. 29, no. 3-4, pp. 459–467, 2001.View at: Publisher Site | Google Scholar
M. Lee, J. Lee, C. Seo et al., "Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1," Food and Chemical Toxicology, vol. 49, no. 5, pp. 1047–1055, 2011.View at: Publisher Site | Google Scholar
Y.-S. Kwon, A. Kobayashi, S.-I. Kajiyama, K. Kawazu, H. Kanzaki, and C.-M. Kim, "Antimicrobial constituents of Angelica dahurica roots," Phytochemistry, vol. 44, no. 5, pp. 887–889, 1997.View at: Publisher Site | Google Scholar
D. Lechner, M. Stavri, M. Oluwatuyi, R. Pereda-Miranda, and S. Gibbons, "The anti-staphylococcal activity of Angelica dahurica (Bai Zhi)," Phytochemistry, vol. 65, no. 3, pp. 331–335, 2004.View at: Publisher Site | Google Scholar
T. Tang, L. Yin, J. Yang, and G. Shan, "Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats," European Journal of Pharmacology, vol. 567, no. 3, pp. 177–185, 2007.View at: Publisher Site | Google Scholar
X. Bai, D. Hu, Y. Wang, Y. Su, X. Zhu, and C. Tang, "Effects of Angelica dahuricaextracts on biological characteristics of human keratinocytes," Chinese Journal of Reparative and Reconstructive Surgery, vol. 26, no. 3, pp. 322–325, 2012 (Chinese).View at: Google Scholar
J.-S. Qu, X.-J. Kang, and S.-L. Zheng, "Extraction of angelica dahurica polysaccharide and its effect on rat skin cells proliferation," Chinese Pharmacological Bulletin, vol. 21, no. 5, p. 637, 2005.View at: Google Scholar
CLSI, "Performance standards for antimicrobial disk susceptibility tests; approved standard—eleventh edition," in CLSI document M02-A11, P. A. Wayne, Ed., Clinical and Laboratory Standards Institute, 2012.View at: Google Scholar
I. A. Darby, B. Laverdet, F. Bonté, and A. Desmoulière, "Fibroblasts and myofibroblasts in wound healing," Clinical, Cosmetic and Investigational Dermatology, vol. 7, pp. 301–311, 2014.View at: Publisher Site | Google Scholar
P. Martin, "Wound healing—aiming for perfect skin regeneration," Science, vol. 276, no. 5309, pp. 75–81, 1997.View at: Publisher Site | Google Scholar
K. A. Kuhn, N. A. Manieri, T.-C. Liu, and T. S. Stappenbeck, "IL-6 stimulates intestinal epithelial proliferation and repair after injury," PLoS ONE, vol. 9, no. 12, Article ID e114195, 2014.View at: Publisher Site | Google Scholar
Z.-Q. Lin, T. Kondo, Y. Ishida, T. Takayasu, and N. Mukaida, "Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice," Journal of Leukocyte Biology, vol. 73, no. 6, pp. 713–721, 2003.View at: Publisher Site | Google Scholar
G. S. Ashcroft, X. Yang, and A. B. Glick, "Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response," Nature Cell Biology, vol. 1, no. 5, pp. 260–266, 1999.View at: Publisher Site | Google Scholar
A. G. Li, D. Wang, X.-H. Feng, and X.-J. Wang, "Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder," The EMBO Journal, vol. 23, no. 8, pp. 1770–1781, 2004.View at: Publisher Site | Google Scholar
W.-Q. Yang, Y.-L. Song, Z.-X. Zhu et al., "Anti-inflammatory dimeric furanocoumarins from the roots of Angelica dahurica," Fitoterapia, vol. 105, article no. 3223, pp. 187–193, 2015.View at: Publisher Site | Google Scholar
Y. Cao, Y. Zhang, N. Wang, and L. He, "Antioxidant effect of imperatorin from Angelica dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway," Journal of the American Society of Hypertension, vol. 8, no. 8, pp. 527–536, 2014.View at: Publisher Site | Google Scholar
X. Chu, M. Wei, X. Yang et al., "Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma," Food and Chemical Toxicology, vol. 50, no. 7, pp. 2368–2375, 2012.View at: Publisher Site | Google Scholar
Y. Wu, W. Gao, X. Xiao, and Y. Liu, "Calorimetric investigation of the effect of hydroxyanthraquinones in Baill on growth," Thermochimica Acta, vol. 429, no. 2, pp. 167–170, 2005.View at: Publisher Site | Google Scholar
X.-F. Zhong, G.-D. Huang, T. Luo, Z.-Y. Deng, and J.-N. Hu, "Protective effect of rhein against oxidative stress-related endothelial cell injury," Molecular Medicine Reports, vol. 5, no. 5, pp. 1261–1266, 2012.View at: Publisher Site | Google Scholar
R. Yaghoobi, A. Kazerouni, and O. kazerouni, "Evidence for clinical use of honey in wound healing as an anti-bacterial, anti-inflammatory anti-oxidant and anti-viral agent: a review," Jundishapur Journal of Natural Pharmaceutical Products, vol. 8, no. 3, pp. 100–104, 2013.View at: Publisher Site | Google Scholar


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Fighting for manufacturers in the Ozarks
Each year, I make a point of visiting several of our area's manufacturers so that I can stay current on the issues they face and see the quality of products being created here in Missouri's 7th Congressional District firsthand. For my 2016 manufacturing tour, I visited Digital Monitoring Products in Springfield, Architectural Systems Inc. in Monett, Holden Industries in Southwest City and Grace Precision Products in Webb City.
The latest data from the Center for Manufacturing Research shows just how important the industry is in our community. Manufacturers in Missouri account for approximately 13 percent of total output in our state. Last year, there were more than 260,000 Missourians who supported themselves and their families working in manufacturing.
Manufacturing is undoubtedly huge in our state already, but it's only getting bigger. The Missouri Department of Economic Development's 2015 report showed that manufacturing was the largest growing industry subsector in our state — creating 5,000 new jobs from May 2014 to May 2015 — and grew at a faster rate than national manufacturer trends.
It is imperative at a national and local level that we embrace manufacturers and their hardworking employees. My "Enforcing Orders and Reducing Customs Evasion (ENFORCE) Act," which I have introduced many times and fought for since I came to Washington, passed into law earlier this Congress. This bill means American border agents will have the necessary tools to stop trading partners who violate US trade laws in order to illegally "dump" products into our country.
Digital Monitoring Products (DMP) in Springfield was the first stop of my manufacturing tour this year, and also one of the 14 exporters in Missouri's 7th Congressional District that have directly benefited from the U.S. Export-Import Bank. Last October, I joined a group of my House colleagues in signing a discharge petition to reauthorize this bank because, without it, companies like DMP in the Ozarks would be at a major disadvantage in the global market. Also, Missouri could've risked losing around $1.5 billion in export sales and thousands of jobs if the bank hadn't been reauthorized.
During my visit to DMP, I couldn't help but notice that despite being a 41-year-old company, they've been able to stay on the cutting edge of their industry. Due to their success, they've begun a process to expand their facility by more than 70,000 square feet and will be doubling the size of their Engineering & Development department.
Manufacturing is not just a crucial part of life in the Ozarks; it is a part of America's history. During my visit to Architectural Systems Inc. (ASI), for example, I learned that their work is in some of America's iconic museums and landmarks. ASI's wall fabrication systems, exterior and interior paneling and engineering are all showcased at the National Museums of the American Indian and African American History and Culture on our National Mall in Washington. ASI is currently involved with constructing what will be iconic additions to New York City's skyline: The Millennium Tower and Hudson Yards buildings. ASI will also be leaving their mark on San Francisco's skyline upon completion of the Transbay Transit Center.
From 'Main Street' in smaller communities to major U.S. cities, Americans rely heavily on the quality and efficiency of manufacturers here in the Ozarks. As your representative, one of my top priorities in Washington will always be to stand up for manufacturers and their role in growing our economy.
Billy Long, the congressional representative from Missouri's 7th District, contributes a regular opinion piece.


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'08 Bravado Buffalo S/C [Add-On | Tuning | Liveries | Template | Sound | Handling] [Version 1.1]
A beefier, slightly redesigned cousin of the original Buffalo bearing a moniker of S/C trades reasonable turning radius and a mediocre V6 for a supercharged whining V8 that looks like it could smash its way out of the engine bay and strangle anyone daring oppose it with its timing belt. Increased mass results in a car that drives more like a steamroller than a sleeper-looking four-door sedan. Only a well-placed shot from an anti-materiel rifle to the engine may halt its destructive march. Subtlety be damned.
Southern San Andreas Super Autos
This is an improved model of original Bravado Buffalo. As of 1.1, it comes as single model with tuning parts and liveries:
– Bravado Buffalo S/C (model name: buffalosc).
Change Log:
+ Added missing seatbelts.
• Tweaked custom grille livery mapping.
• Tweaked liveries: Bruise Blue OEM Stripe (corrected grille mapping), Raging Red OEM Stripe (corrected grille mapping, more vivid red), Your Ex-Girlfriend's Enemy (corrected grille and skirt mapping), Ferocious Flames (spoilers are no longer coloured).
• Minor model fixes.
Initial release.
• Full livery support: 4K template available in the archive.
• Body: remodelled rear fascia (reminiscent of 2006-2010 Dodge Charger), new headlight clusters, working fog lights, new badges, new grille with transparent mesh, front plate, third brake light, brighter light textures, various minor improvements.
• Tuning: 7 liveries, custom front bumpers, grilles, hoods, spoilers, exhaust tips and door trim.
• Interior: added pedals, added automatic transmission shifter, improved rear seats.
• Wheels: colourable steel rims with Bravado logo, colourable brake calipers (support secondary colour).
• Engine: new shaking V8 model (supports secondary colour).
• Handling: higher top speed, stronger understeer at higher speed, increased mass.
• Sound: custom V8 engine sound with supercharger whine.
• All basic vehicle functions: breaking glass, dirt mapping, all LODs etc.
Rockstar Games – original vehicle model.
Voit Turyv – vehicle model, UV mapping and templating, tuning parts.
Eddlm – custom handling.
LamboFreak – custom soundbank.
matej, Valante Luize Sushi – screenshots.
3D Artists:
DynamoHotRun – custom bash bars, custom front bumpers.
GhostRiderPT – headlight casing model.
le_shark – improved trunk model.
MrKote – improved rear bumper model, custom grilles, custom hood.
Graphics And Livery Artists:
(Ambient) – Bruise Blue OEM Stripe, Raging Red OEM Stripe, S/C Black Trim, Your Ex-Girlfriend's Enemy.
Boywond – Buffalo S/C badges.
Smukkeunger – Grey Bravado Fender Stripes.
TheSecretPower – Ferocious Flames.
The Shotty – Off-Duty.
If you want to modify the model or reupload it somewhere else, make sure to contact me and give credit.
Installation guide in a readme file in the archive.
Cooool Mod, Right !!!
Link Download : https://dl1.9gtamods.com/index.php?act=dl&id=1567045491


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Recycling Distillation Technique saves gallons of water during the process of distillation. The technique was invented by Professor Krishan Kumar Sharma, Former Vice Chancellor and Head Department of Zoology M.D.S. University, Ajmer (Rajasthan) in the year 2004.
Sharma,K.K.(2004) Modification of distillation processes in laboratories and industries to conserve water. I.J.Env.Sci.8:108,116