Regularized generalized canonical correlation analysis (RGCCA) is a generalization of regularized canonical correlation analysis to three or more sets of variables, which is a component-based approach aiming to study the relationships between several sets of variables. Sparse generalized canonical correlation analysis (SGCCA) (proposed in Tenenhaus et al. (2014)), combines RGCCA with an `1-penalty, in which blocks are not necessarily fully connected, makes SGCCA a flexible method for analyzing a wide variety of practical problems, such as biology, chemistry, sensory analysis, marketing, food research, etc. In Tenenhaus et al. (2014), an iterative algorithm for SGCCA was designed based on the solution to the subproblem (LM-P1 for short) of maximizing a linear function on the intersection of an `1-norm ball and a unit `2-norm sphere proposed in Witten et al. (2009). However, the solution to the subproblem (LM-P1) proposed in Witten et al. (2009) is not correct, which may become the reason that the iterative algorithm for SGCCA is slow and not always convergent. For this, we first characterize the solution to the subproblem LM-P1, and the subproblems LM-P2 and LM-P3, which maximize a linear function on the intersection of an `1-norm sphere and a unit `2-norm sphere, and an `1-norm ball and a unit `2-norm sphere, respectively. Then we provide more efficient block coordinate descent (BCD) algorithms for SGCCA and its two variants, called SGCCA-BCD1, SGCCA-BCD2 and SGCCA-BCD3, corresponding to the subproblems LM-P1, LM-P2 and LM-P3, respectively, prove that they all globally converge to their stationary points. We further propose gradient projected (GP) methods for SGCCA and its two variants when using the Horst scheme, called SGCCA-GP1, SGCCA-GP2 and SGCCA-GP3, corresponding to the subproblems LM-P1, LM-P2 and LM-P3, respectively, and prove that they all


stage renal disease, which carries a heightened risk of atherosclerosis and other co-morbid conditions. Dialysis treatment per se can bring additional risk factors for inflammation, such as increased risk of local graft and fistula infections, impure dialysate or bio-incompatible membranes. Our study was designed to determine whether a hemodialysis session leads to an acute substantial alteration in the plasma levels of the proinflammatory cytokines interleukin (IL)-6, IL-1b and tumor necrosis factor (TNF)-a, the Tlymphocyte activation factor soluble IL-2 receptor (sIL-2R), and an inflammation mediator and chemotactic granulocyte factor, IL-8, in end-stage renal disease patients receiving chronic intermittent HD. In this study, 21 (12 male/nine female) patients undergoing chronic hemodialysis were enrolled. The acute effect of a hemodialysis session on serum cytokine concentrations was assessed by comparison of pre-hemodialysis and post-hemodialysis determinations. Serum IL-1b, sIL-2R, IL-6, IL-8 and TNF-a levels were determined with chemiluminescence enzyme immunometric assays. A significant difference was not observed for IL-1b, IL6, TNF-a, and sIL-2R concentrations in pre-hemodialysis and post-hemodialysis specimens (p /0.05). Serum median (25th /75th percentiles) IL-8 concentration was 69.4 (34.9 /110.3) pg/ml before hemodialysis, and decreased to 31.5 (18.0 /78.8) pg/ml following hemodialysis (p : 0.006). Clearance of IL-8 increased by 0.479/0.08 pg/ml for each unit increase in pre-dialysis IL-8 (p B/0.001) and decreased by 5.639/2.59 pg/ml for each unit increase in predialysis urea mmol/l (p B/0.05). In conclusion, the results of our study demonstrate that a hemodialysis session markedly decreases IL-8 concentration, which is significantly affected by predialysis concentrations, indicating that removal of IL8 is a concentration gradient-dependent action, but does not change the serum levels of IL-1b, sIL /2R, IL6, and TNF-a, underlining importance of the structural characteristics of the molecules.


: The tool wear is an unavoidable phenomenon when using coated carbide tools during hard turning of hardened steels. This work focuses on the prediction of tool wear using regression analysis and artificial neural network (ANN). The work piece taken into consideration is AISI4140 steel hardened to 47 HRC. The models are developed from the results of experiments, which are carried out based on Design of experiments (Response surface methodology). The cutting speed (V), feed (f) and depth of cut (a )are taken as the inputs p and the wear (V ) is the output. The results reveal that the ANN provides better accuracy when compared to b Regression analysis.


Most students in tertiary institutions nowadays have remarkable admittance to contemporary music and use them in both expected and unexpected ways. They spend hours daily listening, singing and dancing to various genre of contemporary music. This paper set out to examine the effects of contemporary music on the academic achievement of the tertiary institution students with focus on Adeyemi College of Education in Ondo State, Nigeria. A descriptive survey design was employed and the targeted populations for the study comprised both students and lecturers in the institution. The instrument for data collection was a structured and well-designed questionnaire guide. Five hundred and forty (540) students were randomly selected from various departments as well as One hundred (100) lecturers, making a total number of six hundred and forty (640) respondents. Data collected were analyzed using descriptive statistics in form of frequencies and simple percentage. The findings divulge that contemporary music is causing students to lose focus on their academic tasks, promotes a high sense of immorality through use of highly offensive language (lyrics) and dance patterns. This has resulted in penetrability of moral impiety, licentious dressing and sexual perversion among students. This study recommends that students should be encouraged to be listening to music that will convey positive character-building messages for edification and desist from music that egg on and motivate unethical acts.


Modern software engineering education is driven by an expectation that industry best practice and state of the art software technologies should not wait until graduation, but should appear early in the undergraduate curriculum. Moreover, students in our programmes have a strong, and well-justified belief that industrial strength project work is well-regarded by potential employers, and have had little difficulty expressing their preference for more relevant courses.In response, we have significantly enhanced the industry linkages and professional focus of our SE programme through a series of initiatives over a four year period. These initiatives have included: the introduction of a more modern development process employing multiple iterations; a novel approach to the first software engineering unit in which the students must extend an existing (phase 1) software system; the involvement of a live industry partner in the advanced software engineering unit, with regular and candid feedback from the company staff; and the provision of detailed support materials for version control and automated unit testing as part of our process infrastructure. This paper details our experiences during this period, the rationale for our process and course structure, and discusses the feedback on our approaches from students and local employers.


The invention relates to a system of a consumer, in particular cigarette pack or pharmaceutical pack, and server, said consumer product comprises a covert coding, wherein the coding is assigned to a cash benefit and can be transmitted via a telecommunication connection to a server, wherein the server is provided to check, if the coding is registered as valid, and a cash benefit in favor of the telecommunications number of the caller will be credited by the server in response to this audit.


Objective To compare dexmedetomidine with midazolam/fentanyl for sedation in children with pulmonary artery hypertension(PAH) after congenital cardiac surgery.Methods Forty children with PAH were randomly divided into two groups after congenital cardiac surgery.The age of children ranged from 3 to 89 months,and weight ranged from 3 to 26 kg.Group A received an infusion of dexmedetomidine(Dex) 0.5 - 1.0 μg/kg bolus for induction,then a maintenance dose of Dex 0.25 - 0.75 μg · kg- 1 · h - 1.Group B received an infusion of midazolam 0.1 mg/kg bolus for induction,then a maintenance dose of 0.5-2.0 μg·kg-1 ·min-1.The maintenance dose offentanyl was 1.0-1.5 μg·kg-1 · h-1.The time of target sedation score,duration of mechanical ventilation,frequency of using other sedatives and prevalence of delirium were compared between the two groups. Other indicators including COMFORT scale,heart rate ( HR),mean arterial pressure (MAP) and pulse oxygen saturation ( SPO2 ) were compared between the two groups among following time points:before infusion,10 min,1 h,4 h,8 h,12 h after infusion.Results Time points after infusion had lower COMFORT scale significantly compared with time points before infusion(26.3 ± 7.3 ) in group A ( P <0.01 ),so as in group B while the COMFORT scale was 23.9 ± 5.9 before infusion.There was no statistics difference of the time to reach the target sedation score between group A and group B [ (4.4 ± 1.5 ) min vs (4.3 ± 1.9 ) min,P > 0.05].The COMFORT scale had no statistic difference among the time points after infusion in the two groups.The COMFORT scale,HR,MAP and SPO2 had no statistic difference between goup A and goup B among time points before and after infusion.Frequency of using other sedatives were significantly lower in group A compare with group B (4.3 ± 3.3 vs 10.7 ± 5.5 ) ( P < 0.01 ).The prevalence of delirium was significantly lower in group A than group B (25% vs 60% ) ( P < 0.05).The duration of mechanical ventilation was lower in group A compare with group B [ (40.9 ± 22.3) h vs (46.1 ± 23.1 ) h] but there was no statistics difference.Conclusion Compare with midazolam/fentanyl,single use of dexmedetomidine had sound therapeutic effects to provide sedation for children with PAH,while the latter could decrease the frequency of using other sedatives and prevalence of delirium.

Key words:
Heart defects,corgenital; Dexmedetomidine; Pulmonary artery hypertension; Children; Sedation; Delirium


This study discusses the effect of airflow on oven temperature profiles, the internal cake temperature and the final cake quality. It was found that the presence of airflow reduced the oscillation in the oven temperature profile from 12.98–30.27% to 3.17–4.02%. The bottom of the oven chamber experienced the greatest reduction in temperature oscillation in the presence of airflow. During the second stage of baking with airflow, the heating rate was increased from 5.07 to 7.52 °C min−1 and 8.35 °C min−1 to the increase of the baking temperature from 160 to 170 °C and 180 °C, respectively. The cake volume expansion rate was also increased 5–10% during second stage when baking with airflow condition. The cakes baked in the presence of airflow had a more porous crumb texture and lower moisture content compared to the cakes baked without airflow.


Abstract : Typical sections of a prototype hypervelocity track installed in a thin-wall tube for an ablation/erosion chamber was designed, fabricated, and tested as a part of an overall cost reduction study for a Proposed Reentry Vehicle Ground Test Facility. An estimated cost savings of 40 to 50 percent may be realized utilizing test results obtained in the present investigation. The original cost estimate was based on conventional and proved concepts for maintaining rail position and straightness which depends on heavy wall tubes with rails fully supported over their full length. The reduced cost concept utilizes a thin-wall vessel with the rails simply supported near the connecting flanges only. Rail alignment and displacement measurements were obtained under varying conditions that would occur in actual operation of such a facility.


Despite substantial efforts in recent years toward the development of new vaccines and drugs against tuberculosis (TB), success has remained elusive. Immunotherapy of TB with mycobacterial Hsp65 as a DNA vaccine (DNA-hsp65) results in a reduction of systemic bacterial loads and lung tissue damage, but the high homology of Hsp65 with the mammalian protein raises concern that pathological autoimmune responses may also be triggered. We searched for autoimmune responses elicited by DNA-hsp65 immunotherapy in mice chronically infected with TB by evaluating the humoral immune response and comprehensive histopathology using stereology. Cross-reactive antibodies between mycobacterial and mammalian Hsp60/65 were detected; however, no signs of pathological autoimmunity were found up to 60 days after the end of the therapy.


The purpose of this article is to consider the socio-psychological phenomenon of cooperation (joint work) in the context of modern conditions of higher education in our country. The approaches of foreign and domestic authors to the definition of the term of interest are analyzed. The authors emphasize the tendency of work in Russian science to consider cooperation as a strategy of behavior in a conflict situation and the lack of adequate psychometric tools to measure joint work in small groups and organizations. The relevance of this study is due, on the one hand, to the lack of significant scientific works in the context, and on the other – the growing need of modern higher education in the revision and refinement of production processes for the effective implementation of teaching. Cooperation in the context of higher education can be seen as a type of interaction characterized by interdependence, distribution of roles and outcomes. An attempt is made to generalize the authors ' opinions and to classify the socio-psychological phenomenon under consideration in higher education on the following grounds: time, subordination, subjective factor, organization, degree of freedom, type of communication, context. Provides examples of cooperation in educational, expert, research, vocational guidance of the teacher. There are four areas in the consideration of the joint work of the subjects of the educational process in higher education. This is the cooperation of nonpedagogical staff, teacher and student, teachers among themselves, students in the framework of both educational and extracurricular activities. A concrete plan of successive steps of theoretical and empirical nature is outlined, aimed at studying the socio-psychological phenomenon of cooperation in the aspect of the functioning of the Russian higher school.


Precommercial thinning is commonly viewed as a means of increasing growth rates of individual trees to alleviate medium-term shortfalls in future wood supply. In fall 1985, a precommercial thinning experiment involving cleaning and four levels of black spruce basal area removal (0,20,40 and 60%) wasestablished in a dense (6,000 stems ha*1), 24-yearold black spruce plantation on a highly productive site near Beardmore, Ontario. After 9 years, total and merchantable net black spruce stand volume and total net stand volume incrementwere greatest in the cleaned control, and lowest in the 60% basal area removal treatment. In contrast, there was relatively little treatment response in quadratic mean diameter. Black spruce stand density management diagrams (SDMD) (Newton and Weetman 1994) usually provided better estimates of stand volumes and 9-year stand growth than preliminary variable density yield tables for this species. Projected black spruce net merchantable yields at the physical rotation age (55 years), based on the SDMD, were greater in the cleaned control than in any of the precommercial thinning treatments, while treatment differences in quadratic mean diameter at rotation age were <1 cm. The cost/benefit of precommercial thinning black spruce on highly productive sites should be carefully examined before large programs are undertaken. Silvicultural alternatives to increase merchantable biomass and the production of sawlogs are discussed in terms of stand treatments and species selection.


In today's data-driven business landscape, Data Analytics (DA) has emerged as a vital tool for organizations to extract insights from their existing data, enabling informed decision-making. While large enterprises have wholeheartedly embraced DA as a strategic asset for operational enhancement, SMEs have been comparatively slower in adopting these transformative solutions. To remain competitive and surpass their rivals, SMEs must recognize the significance of harnessing their data assets effectively to drive decision-making processes. This research aims to delve into the challenges hindering the adoption of DA among SMEs, particularly focusing on issues such as inadequate information infrastructure and limited awareness of the benefits that DA can offer. Furthermore, this study investigates the implementation of data analytics as a practical solution to address these challenges, providing a comprehensive analysis of both the advantages and disadvantages associated with DA adoption in the SME context. By shedding light on the untapped potential of data analytics, this research aims to empower SMEs and equip them with the necessary tools to thrive in today's digitally-driven era of business.


This paper explores the connections between the 1930s Great Depression and the 2008 Financial Crisis. It also goes into great detail regarding the causation, consequences, and changes that surrounding the 2008 Great Recession. Particularly, the change in federal monetary policy during the early 2000s saw a spike in the amount of loans and mortgages. Accompanied by the positive expectations and aspirations of the investors, the housing market boomed. As a result, financial derivatives of asset-backed securities also flooded the market. In the end, this over-inflation of the housing market and its derived products created a housing bubble, which ultimately led to a catastrophic financial crisis when too high a leverage and inability of borrowers to pay back loans burst this overly-optimistic bubble. Upon the occurrence of this financial crisis, new policies were enacted and acts were set in place. Through interpreting the findings of 2022's Nobel prize winning economists, individuals and groups alike are able to protect themselves from inevitable financial crises that take place in the future.


ABSTRACT. A new species of Bryconops is described from the rio Xingu Basin, Brazil, that differs from all congeners by the following combination of characters: predorsal scales 8–9, perforated scales in the lateral line 43–45, and pigmentation pattern composed of wide silvery midlateral band on body, hyaline dorsal and anal fins (in alcohol), and dark blotch on distal half of dorsal caudal-fin lobe. The new species shares with members of the subgenus Bryconops maxillary relatively short, edentulous or with one conical tooth, and gill rakers without ossified denticles. The middle and lower Xingu support a remarkable diversity of Bryconops composed of at least nine species-level taxa; comments on their local distributions and habitats are provided, as well as a key to their identification.


Nonrecurring congestion creates significant delay on freeways in urban areas, lending importance to the study of facility reliability. In locations where traffic detectors record and archive data, approximate probability distributions for travel speed can be determined from historical data; however, the coverage of detectors is not always complete, and many regions have not deployed such infrastructure. This paper describes procedures for estimating such distributions in the absence of this data, considering both supply-side factors (reductions in capacity due to events such as incidents or poor weather) and demand-side factors (such as daily variation in travel activity). Using data from the Dallas metropolitan area, the supply-side analysis identifies probability distributions that fit observed speed data, and develops regression models for estimating their parameters. For cases in which data is available on demand variations, a demand-side procedure is presented for refining the analysis to account for this source of uncertainty.


Abstract : Significant number of airfield pavements are constructed with Portland Cement Concrete (PCC). Effectively restoring damaged PCC sections in military airfields requires a well-formulated repair plan. This study investigates the feasibility and efficiency of using different precast concrete panel installation techniques for contingency repair of damaged airfield pavements. High-density polyurethane (HDP) foam and flowable fill were selected as bedding and leveling materials after literature review. Deep injection using HDP foam as well as conventional leveling using cement mortar were investigated to determine the impact of leveling techniques on repair performance. Performance of the repaired sections was characterized by load transfer efficiency, joint stiffness and deformation energy dissipated through the pavement foundation. A heavy weight deflectometer (HWD) along with an F-15 gear simulator was used to determine the stiffness properties and accumulation of plastic deformations after each load interval during performance testing. Decay of joint stiffness and load transfer efficiency, as well as increase in deformation energy, were calculated as a function of number of load applications. The results indicate a significant increase in the deformation energy and considerable loss of joint stiffness with number of load applications when flowable fill was used as leveling material. This study reveals that precast panels installed with HDP foam performed superior compared to precast panels installed with flowable fill. Additionally, precast panels installed using deep injection method performed better in terms of higher load transfer efficiency, higher joint stiffness and lower dissipated deformation energy. This study suggests that precast concrete panels leveled using HDP foam deep injection method outperformed other investigated permutations.


This paper introduced the application of Materials Studio and Crystal Maker in the teaching of Solid State Physics. Material studio software can assist to classroom teaching in the crystal structure and band theory teaching effectively through modeling,simulation and demonstration. And the Crystal Maker software can help the lecture more vividly by presenting the crystal structure and simulating the corresponding crystal diffraction pattern,which can vividly tell the contents of the reciprocal space and the diffraction of the crystal.


To take into consideration the forward and reverse facility integration in reverse logistics network design, this paper proposed a mixed integral linear programming(MILP) model to address the issues of site selection and flow allocation in a reusable bottle recycling system. The model mainly focuses on the decision about whether the distribution and recycling facilities should be integrated at one location. And this paper also gives numeric example to validate the model and make a quantitive analysis on the benefits brought by this facility integration.


COPYRIGHT © 2023 Balogun, Banke-Thomas, Galvin and Boateng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Social inequality and equity in community actions for health


NOSOCOMIAL infection has become a serious problem in recent years. A substantial number of these infections are caused by Gram-negative bacilli. 1 The emergence of these organisms as a major cause of infection in hospitalized patients is due, in part, to the control of streptococcal and staphylococcal infections with effective antibiotic therapy. Gram-negative bacillary infections are a special threat to patients with impaired hostdefense mechanisms. Most hospitals are populated with increasing numbers of these patients due to improvements in the management of a variety of chronic debilitating diseases. Agents such as adrenal corticosteroids, alkylating agents, and antimetabolites are being used extensively in the fields of organ transplantation, autoimmune disorders, hematological diseases, and metastatic malignancies. These agents contribute to the problem because their toxicity includes myelosuppression and impairment of immunological mechanisms. Reverse isolation has been an accepted technique for protecting compromised hosts from acquiring nosocomial infection. However, the effectiveness


The academic demands on a typical professor mean that his or her time must be used to maximum advantage. There is advising of students, research, teaching, grading, class preparation, committee work, faculty meetings and other activities that take precious time. Increased student enrollment means more student, larger classes and more sections to be taught. In order to address these issues, the writer has developed and approach to designing re-usable classes that allow them to be used multiple ways to help with the time demands on a professor. They can be used to create courses that help with the problems created by increase class sizes, number of sections to be taught. They also can be made into revenue source, for the university. When used as described herein, the approach also gives more time to the professor and increases the potential for student learning. The approach is presently being used at Georgia Institute of Technology and is providing its self a very good method.


1. The effects of variation in dietary sodium intake on biochemical indices of sympathetic activity were investigated in normal subjects.


Quantum yields for the direct trans cis (Φlc) and cis trans (Φcl,) photoisomerization of 4-nitro-,4,4′-dinitro-, and 4-nitro-4′-methoxystilbene (NS, DNS, and NMS, respectively) were measured in solution at room temperature as a function of the concentration of quenchers (ferrocene, azulene, and oxygen). The results are in full agreement with a previously proposed reaction scheme for NMS, involving a triplet state as an intermediate in the trans cis photoisomerization and both triplet and excited singlet states in the cis trans photoisomerization. The branching ratios for decay of twisted configurations of the first excited singlet (1p*) and the lowest triplet (3p*) into the ground states and the yields for intersystem crossing from the first excited trans and cis singlet configurations to the lowest triplet state (Φlisc and Φcisc, respectively) were determined. Φlisc and Φcisc are large (0.45–0.86) for NS and DNS and significantly smaller for NMS in polar solvents. Since the trans triplet state (3t*) is in thermal equilibrium with 3p* it is this 3t* ⇄ 3p* equilibrium which is accessible for the influence of triplet quenchers and solvent properties in the cis ⇄ trans photoisomerization. At room temperature oxygen quenches mainly 3p* while at lower temperatures (between 0 and — 140°C) also3t* is quenched. The yields for the conversion 1t* 1p* and for formation of 4a,4b-dihydrophenanthrene (DHP) are small. From the kinetic analysis no indication was found for involvement of excited states of DHP in the cis trans photoisomerization of 4-nitrostilbenes.


Many systems with multiple operating conditions have components such as sensors and actuators that remain invariant to the operating conditions. This paper investigates the simultaneous stabilization of such systems using the stable inverse approach. For common components with poles and zeros in the open left half plane, the results show that the controller order can be reduced. For common components having poles and zeros in the closed right half plane that result in an unstable inverse, an interpolation scheme is proposed to develop a stabilizing control.


A water shortage is one of the most important factors for development and management of water resources. For reliable water shortage measurement in a stream, Korea Water Resources Corporation(KOWACO) founded five foot Parshall flume at Yong-dam experimental watershed in 2000. The Parshall flume has a specially designed shape to facilitate flow measurements by eliminating sediment deposition problem that could lead to an incorrect measurement. In this study, computational fluid dynamics(CFD) model was used to analyze flow behavior of Parshall Flume under free discharge of five headwater level cases. The flow rates computed by CFD model are compared with those by ISO`s formula, USBR`s formula and stage-discharge rating curves. Flow rates computed by ISO`s and USBR`s formula are mostly same, but flow rate by CFD model is larger than empirical value by 9% and flow rate by stage-discharge rating curves is less than empirical value by 16%


SUMMARY1. The report on the chromosome number n=14 and 2 n=28 in the taxon investigated was first recorded by the author in 1961.2. In the present investigation, the detailed karyotype analysis of the species has been studied.3. Four distinguishable types of chromosomes have been recorded as revealed from the idiogrammatic representation of the karyotype of the species.4. Of the fourteen pairs of chromosomes, one pair is long and secondarily constricted and the rest are medianly constricted.


Objective To evaluate the effect of dynamic hip locking plate for the treatment of unstable intertrochanteric femoral fractures.Methods 46 cases of unstable intertrochanteric femoral fractures were treated with dynamic hip locking plate.Results All patients were followed up for 6 ~ 32 months,averaged 14.7 months.The clinical results were evaluated by the Harris hip scoring system.Among the patients,37 cases were excellent,6 good,and 3 poor,and the excellent and good rate was 93.5%.Conclusions Locking plate for unstable intertrochanteric femoral fractures can provide solid and stable fixation with few complication.


We give examples of Shimura correspondence for rational modular forms f of weight 2 and level p^2, for primes p<=19, computed as an application of a method we introduced in \cite{Pacetti-Tornaria}. Furthermore, we verify in this examples a conjectural formula for the central values L(f,-pd,1) and, in case p = 3 (mod 4), a formula for the central values L(f,d,1) corresponding to the real quadratic twists of f.


Phytochemical study of the methanol extract from?Dendrobium infundibulum?(Orchidaceae) led to isolation of nine pure compounds including?two new compounds (dendroinfundin A and dendroinfundin B) and seven known compounds (ephemeranthol A,?moscatilin,?aloifol I, batatasin III, 3,3'-dihydroxy-4,5-dimethoxybibenzyl,??3,4'-dihydroxy-3',4,5-trimethoxybibenzyl?and dendrosinen B). Their structures?were?determined from their spectroscopic data. All compounds were then examined for their lipase and alpha-glucosidase inhibitory activities. Dendrosinen B (IC50?= 295.0?37.9 ?M) showed moderate inhibitory activity against?lipase when compared with orlistat (IC50?= 31.4?0.6 nM). Strong anti alpha-glucosidase agents were batatasin III (IC50?= 148.8?8.4 ?M) and dendrosinen B (IC50?= 213.9?2.4 ?M), which were more potent than acarbose (IC50?= 809.1?22.2 ?M).


Background: The histologic type of thyroid carcinomas includes follicular, papillary carcinomas, and medullary carcinomas. The reports about the histological, immunohistochemical, and ultrastructural characteristics of each kind of thyroid carcinomas were common, but the simultaneous occurrence of a medullary and papillary carcinoma as 2 distinct tumors has been reported extremely rarely. Objects: To explore the pathogenesis, clinicopathological characteristics, immunohistochemical phenotype, and pathological diagnosis of medullary thyroid carcinoma combined with papillary thyroid microcarcinoma. Methods: The clinicopathological characteristics and immunohistochemical phenotype of a patient with left medullary thyroid carcinoma combined with right papillary thyroid microcarcinoma were retrospectively stu-died. Then, relevant literature was thus reviewed. Results: General appearance: The size of the left thyroid lobe was 2.5 × 2 × 1 cm, the cut surface was gray and red, and a nodule with a diameter of 1.3 cm could be observed. The cut surface of the nodule was gray and yellow, solid, and hard. The size of the right lobe of the thyroid gland was 0.7 × 0.6 × 0.5 cm, and a gray nodule with a diameter of 0.4 cm was seen on the cut surface. The cut surface of the nodule was gray, solid, and hard. Observation under the microscope: the left nodular tumor cells were round, oval, or plasma cell-like, some areas were arranged in nests, and some areas were arranged in beams. Calcification and sheet-like eosinophilic amyloid deposits could be seen in the stroma. The nodule on the right showed a branched papillary structure, the covering cells on the surface of the nipple were ground glass-like nuclei, and nuclear grooves and pseudo-inclusion bodies in the nucleus could be observed. Immunohistochemistry: left lobe tumor cells Calcitonin, CEA, TTF-1, CD56, CgA, and Syn are all (+), CK19 and TG were both (−); right lobe tumor cells CK19 and TG are both (+), Calcitonin, CD56, CgA, and Syn are all (−). Conclusions: The origin, clinicopathological manifestations, and immunophenotypes of medullary thyroid carcinoma and papillary thyroid carcinoma are different. It is relatively rare for the two to occur at the same time. The diagnosis mainly depends on the microscopic morphology and immunophenotype characteristics.


This paper concerns the development of innovative composite floor systems, comprising timber beams and prefabricated concrete slabs. For the development of this new system, two properties were regarded as vital, as follows: (1) good stiffness, and (2) a high degree of prefabrication. Shear connection systems installed using completely dry processes were used. Innovative and very efficient materials, such as fiber-reinforced concrete (FRC) and modified wood, were used for the manufacture of the specimens. The research reported in this paper was conducted in two phases, as follows: (1) the mechanical properties of different shear connectors were investigated (Phase A), and (2) on the basis of these experiment's results a second investigation was carried out in order to study the behavior of full-scale timber-concrete composite slabs (Phase B). During Phase A four different configurations, with a total of eight specimens, were laboratory tested in shear. During Phase B two full-scale floor elements, each with a different shear connection system, were laboratory tested in bending. The two shear connector systems used in the investigation were (1) shear anchor-keys of furfurylated wood, and (2) inclined steel tubes. Both of the proposed connection systems performed more than satisfactorily, showing a very high degree of composite action even at load levels close to the failure load. Moreover, it appeared that the assembling of the prefabricated fiber-reinforced concrete slab with the underlying beams occurred in an extremely easy manner. (C) 2014 American Society of Civil Engineers. (Less)


AIM: To assess the effect of estrogen on the gene expression of caveolin-1 in rat vascular smooth muscle cells (VSMCs). METHODS: Wistar rats were ovariectomized and subjected to subcutaneous implantation of placebo pellets (OVX+V group) or estradiol pellets (OVX+E group). 2 weeks after implantation, the expression of caveolin-1 gene in endothelium-denuded aortic tissue was examined by RT-PCR. Furthermore, Northern blotting was used to analyze the mRNA expression of caveolin-1 in cultured rat VSMCs. RESULTS: RT-PCR showed that expression of caveolin-1 gene was significantly higher in OVX+E group than that in OVX+V group. Northern blot analysis showed that the mRNA expression of caveolin-1 was higher in VSMCs pretreated with 17β-estradiol (17β-E 2) than that in VSMCs without 17β-E 2 pretreatment. CONCLUSION: Estrogen up-regulates the gene expression of caveolin-1 in the vascular wall, partially indicating the cardiovascular effect of estrogen. [


We study polycrystalline samples of KCu 3 As 2 O 7 (OH) 3 , a new candidate spin-1/2 kagome antiferromagnet, by magnetic susceptibility and heat capacity measurements above 2 K. The unique arrangement of the 3 z 2 - r 2 and x 2 - y 2 orbitals on the Cu 2+ kagome net is noted and compared to the orbital patterns found in other kagome minerals. It is suggested that this orbital arrangement gives rise to one antiferromagnetic and two ferromagnetic interactions on isosceles triangles forming a highly distorted kagome lattice. KCu 3 As 2 O 7 (OH) 3 is found to show an antiferromagnetic long-range order at T N =7.2 K. Remarkably, a spin entropy is more gradually released upon cooling below T N compared with a conventional magnetic long-range order, which may originate from the geometrical frustration still present in this highly distorted kagome lattice.


Objective To explore the clinicopathological characteristics of esophageal cancer in Henan and its relationship with related proteins.Methods The pathological data of 541patients with histopathologically confirmed esophageal cancer were retrospectively analyzed.Results In 541patients,363 were males and 178 were females.Microscopy confirmed squamous cell carcinoma in 519cases(95.9%).TNM stageⅡaccounted for 64.33%,and fewer patients were found in stage Ⅳ.The focus was most commonly located at upper thoracic part in 65patients,middle part in 385 patients,and lower part in 91patients.The expression of epidermal growth factor receptor(EGFR)increased in lymph node metastasis group than that in non-metastasis group,the level of cluster differentiation antigen 56(CD56)was higher in poor-differentiated group than that in well-differentiated group,and the positive rate of Ki67was higher in advanced group than that in early group(P0.05).Conclusions The esophageal cancer is mostly located at middle thoracic part, followed by lower part,and is seldomly found at upper part in Henan.Male patients are more than female patients. Fewer patients in early stage visit hospital.The expressions of EGFR,CD56and Ki67increase in esophageal carcinoma patients,which may be associated with the degrees of esophageal malignancy,invasion and metastasis.


We numerically investigate arrays of metallic nanoparticles deposited on a glass substrate and covered by a liquid-crystal material. Extinction spectra at normal incidence are computed using the finite-difference time-domain method, and we show that by rotating the optical axis around an axis orthogonal to the main direction of illumination, it is possible to tune the resonance of the system according to a simple law. The spectral width of the tunability is studied as a function of different parameters.


For a fixed integer k, all but a finite number of line-transitive linear spaces with lines of size k are point-primitive. In this paper, we study the finite class of examples where a line-transitive group is point-imprimitive, that is, preserves a non-trivial partition of the point set. We restrict to the case where (i) the number of unordered point-pairs, on a given line, contained in the same class of the partition is at most eight, and (ii) some nonidentity group element fixes setwise each class of the partition, and also fixes a point. This family of linear spaces was studied by Ngo Dac Tuan and the third author in 2003, leaving several problems unresolved. We prove that all examples in this family are known, namely Desarguesian projective planes of appropriate orders, and an additional example on 91 points. The result is obtained by a combination of theoretical analysis, and exhaustive computer search.


The Dovinė River is a second biggest tributary (length 47 km, catchment area 588.7 km2) of the Šešupė River. A characteristic feature of the basin is lakes taking 7.3 % of the total area. In early 1970s, three lakes (Dusia, Simnas and Žuvintas) located in the upper and middle reaches of the Dovinė River were dammed trying to increase the low runoff of the heavily polluted Šešupė River at the Marijampolė City (Baltrušaitienė, Bridickaitė, 1979). As a lot of undesirable hydrological and ecological consequences of the damming arose in the lakes (Kilkus, 2003), the possibilities to return them to the natural state have been discussed often enough of late years. In 2003, the project Renaturalisation of the Dovinė River basin sponsored by the PIN/MATRA foundation has been started on, and some new data on the hydrology as well as hydrochemical and hydrophysical properties of surface water in the basin have been collected during field studies in the summer of 2004. A socalled hydrometrical survey (Januškis, 1981) has been carried on during a short period of continuous drought to estimate the space distribution of low runoff, groundwater discharge sites as well as ephemeral streams. Some hydrophysical and hydrochemical parameters such as water temperature (T), pH and electric conductivity (C) have been measured at the same sites, too.


The understanding of object-oriented programming languages is generally based on their included features. In this understanding, these features form the underlying concepts of both the languages and the modeling processes based on the languages. Consequently, object-oriented languages are generally compared and evaluated based on these features. Alternatively, object-oriented programming languages may be seen as supporting a conceptual perspective on programming. Instead of the features, the underlying concepts are then concepts such as phenomenon and concept, and also the abstraction processes in relation to these concepts. A comparison of object-oriented languages from the conceptual perspective gives additional understanding of each language and the mutual relations and differences between these.


In Hezhou and some of her towns,some Hakka people have been keeping the old foodway of Leicha,Micha and Ximocha so far.This custom implies very deep historic and cultural connotation.Ximocha called by the local people is the contemporary legacy of teaism prevailing in Tang and Song dynasty,which is extremely valuable.And this custom coincides with the pursuit of healthy eating in modern society,so it has great marketing economic value.


Dr. Katsutoshi Komeya joined Toshiba Corporation after graduating from the Faculty of Engineering, Yokohama National University, in March 1962 and in the following year, 1963, he started research on synthesizing and sintering aluminum nitride (AlN) and silicon nitride (Si3N4), an area in which there were very few examples of research. After several years of basic research, he and his colleagues discoverd those sintering auxiliaries that represent a creative sintering principle applicable to both nitrides, and became the first person in the world to establish a starting point for creating new functional materials. Thereafter, materials were developed on a worldwide scale based on this principle. AlN is now used for semiconductor substrates, packing materials, and parts for semiconductor manufacturing processes as a high-thermal conductive material. Furthermore, Si3N4 is now employed for engine parts and bearings as a high-temperature, high-strength and excellent wear resistant material.This paper dealing with sintering of AlN was the first paper to discuss the influences of various additives on the sintering of AlN. Examination of the roles of 30 types of additives clarified that rare-earth oxides, such as Y2O3, La2O3, and Sm2O3, and alkaline earth compounds, such as CaCO3 and BaCO3, form aluminates under high-temperature sintering and that densification is promoted by liquid phase sintering. It has also been shown that, when SiO2 is added to AlN, a sintered body of plate-like texture can be obtained by generating AlN polytypoid but densification is prevented by the generation of this phase. In addition to the above, this paper clarified the following two points, which are now deemed as important findings for the implementation of AlN. First, it was found that a black-gray color was created when compounds that contain transition elements, such as Ti, Zr, and Hf, are added. Currently, these compounds are used as important additives to give a black color to AlN packages. Second, measurement of the bending strength of various sintered bodies consisting of AlN and additives revealed that, among those materials where densification is achieved, Y2O3 and CaCO3, which are now employed in practical applications, exhibit only low strength, but La2O3 and Sm2O3 are effective for providing high strength. As the achievement of high strength is now considered the most important subject in the field of AlN ceramics, this paper provides important findings for the solution of this problem as well.As described above, this pioneering paper was the first to clarify those sintering auxiliaries that are now basic components of ceramics and their effects in the initial stage of the development of AlN ceramics. Furthermore, this paper also suggests those additives that are effective for achieving high strength as well as for coloring and is very frequently referred even though it is written in Japanese. I therefore recommend it as "a paper that leads the studies of ceramics in the 20th century", as I judge that it is really worthy of that honor.


FIELD: oil-and-gas industry. SUBSTANCE: proposed method comprises making the mortar to be injected to well and forced into interval to be isolated. After injection of mortar into well in amount of 10% of total amount, portion of fibro fibers is added thereto under mortar jet. First portion of fibro fibers is fed in 3 mm length, minimum, and in minimum amount of 1 kg per 1 m of mortar. At insignificant increase in injection pressure, 2 nd , 3 rd and 4 th portions of fibro fibers (6, 12, 18 mm-long) are added in portions of 2-5 kg per 1m of mortar till pressure of 70-90% of permissible pressure to operating string or to pools. Injection is terminated to force mortar with fibro fibers, process fluid to permissible pressure to string or to pools. Solution residues are washed off by back-flushing. Well is closed for mortar hardening period. EFFECT: higher efficiency of isolation, fast process.


This study examines how a rapid change in social perceptions of a national-origin group triggered by the COVID-19 pandemic influenced immigration judges' decision-making in US removal proceedings. Using originally compiled court data on removal proceedings decided between 2019 and 2020, we applied a difference-in-differences framework to produce three key findings. First, consistent with theory of event stigma, Chinese respondents experienced a significantly higher removal rate during the early pandemic period. Second, consistent with theory of associative stigma, East and Southeast (E/SE) Asian respondents also experienced a significantly higher removal rate during the early pandemic period. Third, the removal rate declined for both Chinese and E/SE respondents during the later pandemic period, but this decline was more gradual and lagged for E/SE Asian than for Chinese respondents. Finally, increases in the number of cases involving Chinese respondents increased the removal rate for E/SE Asian respondents during the early months of the pandemic. The last two findings suggest that associative or indirect stigmatization may be harder to combat than direct stigmatization owing to the implicit nature of bias underlying associative stigma. This study highlights the socially constructed nature of national origin groups, and the importance of both direct and indirect stigmatization in the production of social inequality. © 2022 Cornell Law School and Wiley Periodicals LLC.


intermediate. Ann Intern Med. 2006;144(7): 465-474. 3. Bodenheimer T, Wagner EH, Grumbach K. Improving primary care for patients with chronic illness: the chronic care model, part 2. JAMA. 2002; 288(15):1909-1914. 4. Robert Wood Johnson Foundation. Improving chronic illness care. http://improvingchroniccare .org/. Accessed December 1, 2006. 5. US Centers for Disease Control and Prevention. National Program of Cancer Registries. http://www .cdc.gov/cancer/npcr/npcrpdfs/0607_npcr_fs .pdf. Accessed January 15, 2007. 6. Frieden TR. Asleep at the switch: local public health and chronic disease. Am J Public Health. 2004; 94(12):2059-2061. 7. New York City Department of Health and Mental Hygiene. The New York City A1C Registry. http: / /www.nyc.gov/html/doh/html/d iabetes /diabetes-nycar.shtml#pt. Accessed February 3, 2007. 8. Steinbrook R. Facing the diabetes epidemic— mandatory reporting of glycosylated hemoglobin values in New York City. N Engl J Med. 2006; 354(6):545-548. 9. Tu JV, Willison DJ, Silver FL, et al. Impracticability of informed consent in the Registry of the Canadian Stroke Network. N Engl J Med. 2004; 350(14):1414-1421. 10. Haynes MA, Smedley BD, eds. The Unequal Burden of Cancer: An Assessment of NIH Research and Programs for Ethnic Minorities and the Medically Underserved. Washington, DC: National Academy Press; 1999. 11. MacLean CD, Littenberg B, Gagnon M. Diabetes decision support: initial experience with the Vermont diabetes information system. Am J Public Health. 2006;96(4):593-595. 12. Littenberg B, Maclean CD. Passive consent for clinical research in the age of HIPAA. J Gen Intern Med. 2006;21(3):207-211.


Objective To compare the draining efficacy of Foley catheter with ttree methods of bladder irrigation after transurethral resection of prostate (TURP).Methods From October 2003 to October 2009,90 patients underwent TURP in our department were randomly assigned into 3 groups,each with 30 patients.All the patients were catheterized with 22F silicon triple-way Foley catheters and underwent bladder irrigations with normal saline,with intermittent template in Group A,continuous template in Group B and continuous-manual combination template respectively.Compared the three groups with tubidity of the urine,the incidence of clot obstruction and bladder spasm.Results The difference of tubidity of urine,the incidence of catheter obstruction and bladder spasm between the three groups were statistically significant (P0.05).Group C have better tubidity of urine,lower incidence of catheter obstruction and bladder spasm.Conclusion Bladder irrigation with continuous or intermittent template could relatively increase the incidence of catheter obstruction and bladder spasm.Continuous-manual combination bladder irrigation had better efficacy of catheter patency maintainance by reducing the incidence of catheter obstruction with clots.


Since the implement of reform-and-open policy in 1978, the thirty years has witnessed the development of Chinese scholar's widespread discussion and deep research on such problems as whether human and nature have ethics relations, anthropocentrism and its value, the intrinsic value and right of nature. They have formed the particular theory viewpoint, discipline model and question consciousness of the Chinese environmental ethics. China has made significant progress in theoretical studies of environmental Ethics. It has played a positive role in promoting the development of its environmental ethics. However, China's environmental ethics is still in the primary stage of exploration, and mature environmental ethics with characteristics of Chinese culture has not yet been developed. In its future development, China's environmental ethics needs to be improved in the following aspects. Firstly, remarkable achievements have been made on introducing and clarifying western ethics thoughts, but efforts made are insufficient on obtaining our own unique decision-making right system, theoretical framework and the construction of environmental ethics with characters of Chinese culture. Secondly, China's environmental ethics has placed great emphasis on theoretic research of environmental ethics out of interest, showing broad and lasting doctrinal disputes, but it has show little concern for the social reality in China. Thirdly, China'senvironmental ethics has been lack of enthusiasm for environmental education which disseminates environmental ethics. Thirty years is far from enough for the development of a new discipline. However, the existence of these issues promises infinite vitality. Moreover, after the reform and open policy, the government has paid great attention to environmental problems, and its extended effect has become the driving force for the harmonious development of the environment ethics theory.


RESULTS: A significant main effect of time (p<0.05) was found for IL-1β, IL-2, IL-8, IL-10, and IL-15. Concentration of IL-1β was smaller at +5 (3.9 ± 0.4 ng/mL), +15 (3.6 ± 0.4) +30 (3.5 ± 0.3), and +60 (3.7 ± 0.4) compared to IP (4.1 ± 0.4). IL-2 was greater after set 1 (10.8 ± 1.0 ng/mL), and set 2 (11.0 ± 1.2) compared to PRE (10.2 ± 1.0), and smaller at +30 (9.9 ± 1.0) compared to IP (11.0 ± 1.0). IL-8 was greater after set 1 (8.4 ± 0.6 ng/mL), set 2 (8.6 ± 0.7), and set 3 (8.5 ± 0.7) compared to PRE (8.0 ± 0.6). IL-10 was smaller at +30 (31.3 ± 7.4 ng/mL) compared to PRE (34.0 ± 7.4), and also smaller at +15 (32.6 ± 7.9) +30 (31.3 ± 7.4), and +60 (33.4 ± 8.6) compared to IP (38.0 ± 8.6). IL-15 was greater at IP (15.5 ± 4.0 ng/mL) compared to PRE (13.4 ± 3.5), and smaller at PRE (13.4 ± 3.5), +30 (11.9 ± 3.3), and +60 (11.6 ± 3.2) compared to IP (15.5 ± 4.0). No condition × time point effects were observed. CONCLUSIONS: Both TS and CS induced an acute cytokine response in resistance-trained women; incorporating intra-set rest (CS) did not appear to affect this cytokine response. Supported in part by a grant from the National Strength and Conditioning Association Foundation.


Floating Point (FP) addition, subtraction and multiplication are widely used in large set of scientific and signal processing computation. A high speed floating point double precision adder/subtractor and multiplier are implemented on a Virtex-6 FPGA. In addition, the proposed designs are compliant with IEEE-754 format and handles over flow, under flow, rounding and various exception conditions. The adder/subtractor and multiplier designs achieved the operating frequencies of 363.76 MHz and 414.714 MHz with an area of 660 and 648 slices respectively.


Wake steering of vertical axis wind turbines (VAWTs) is investigated experimentally and numerically via stereoscopic particle image velocimetry and Reynolds averaged Navier-Stokes simulations. Three different blade pitch angles (-10°, 0°, 10°) of straight H-type VAWTs are adopted to deflect and deform the wake. The experimental results confirm the efficacy of blade pitching on the wake steering, and validate the simulation for both moderate and significant wake deflections. The simulation is then extended to full-scale VAWTs, exploring the wake deflection effects on the power performance of VAWT arrays. The effects of inter-turbine distances and pitching configurations are considered. With the upwind VAWT deflecting the wake, the overall power coefficient is increased by 41%.


Turbine generator (T-G) units with low tuned concrete foundations were investigated experimentally during both startup and normal operating conditions. The dynamic response of the turbine generators and their foundation systems were characterized by resonance curves obtained during the startup transient and by vibration mode shapes at the normal operating condition. No severe resonance at the fundamental frequencies of the system was observed. The deflection or displacement of the foundation pedestal does not lead to unacceptable T-G vibration. The experimental results are compared and discussed with some previous theoretical studies.


The utility model relates to a device for methane decarburization and synchronous preparation of nanometer calcium carbonate. The device comprises a calcium hydroxide storage tank, wherein a liquid outlet of the calcium hydroxide storage tank leads to a cavity of a micro-channel reactor, a methane inlet of the micro-channel reactor is connected with a methane source through a microporous membrane and an air pump, an outlet of the micro-channel reactor is connected with a gas-liquid separator, a liquid outlet of the gas-liquid separation connector is connected with a liquid inlet of the calcium hydroxide storage tank through a liquid inlet pump, and a gas outlet of the gas-liquid separator is connected with a purified gas pipeline, and an ultrasonic wave generation device is arranged at the bottom of the micro-channel reactor. Through application of the device, the nanometer calcium carbonate is obtained while CO2 in methane can be removed, ultrasonic wave cavatition is adopted in a production process so as to promote the dissolution of calcium hydroxide and reaction between the calcium hydroxide and the CO2 and improve the removal efficiency of CO2; and simultaneously, the device can promote the dispersion of the nanometer calcium carbonate, reduces agglomeration and improves the quality of products.


The Crimson-spotted rainbowfish (Melanotaenia fluviatilis) from the Murray-Darling basin of Australia is a common indicator species in Australian ecotoxicology. Biochemical changes have been investigated in this species, but not molecular markers of ecoto


Two-photon-excited fluorescence spectroscopy is a powerful tool to study the structural and electronic properties of optically active complexes and molecules. Although numerous lanthanide complexes have been characterized by two-photon-excited fluorescence in solution, this report is the first to apply such technique to actinide compounds. Contrasting with previous observations in lanthanides, we demonstrate that the two-photon absorption properties of the complexes significantly depend on the metal (4f vs 5f), with Cm(III) complexes showing significantly higher two-photon absorption cross-sections than lanthanide analogues, and up to 200-fold stronger emission intensities. These results are consistent with electronic and structural differences between the lanthanide and actinide systems studied. Hence, the described methodology can provide valuable insights into the interactions between f-elements and ligands, along with promising prospects on the characterization of scarce compounds.


growths on the tissue of a woman's Human cervix. The cervix is part of the uterus that opens to the vagina. Growths are usually f lat and invisible. Papillomavirus ● High-risk types can cause cell womenshealth.gov changes that can lead to cervical 1-800-994-9662 cancer over time, if those cell (HPV) and TDD: 1-888-220-5446 changes are left untreated. Having high-risk HPV is not the same as Genital Warts having cervical cancer. Usually, these high-risk HPV types cause no health problems at all and go away Q: What is human papillomavirus on their own. Persistent high-risk


ABSTRACT The high-quality draft genomes of two Vibrio parahaemolyticus strains, one that causes the acute hepatopancreatic necrosis disease (AHPND) in cultured shrimps (FIM-S1708+), and another that does not (FIM-S1392−) are reported. A chromosome-scale assembly for the FIM-S1392− genome is reported here. The analysis of the two genomes gives some clues regarding the genomic differences between the strains.


Apoptosis is one of the morphological depiction methods of cell death. Apoptosis appeare in all on the living process of organism. It also is one of the factors which regulates the normal physiological process and disease occurness of organism. At present, apoptotic researching had made great progress in the field of the molecular mechanisms, significance of biology, morphological and biochemical characteristics and gene regulation. This article compared a few of apoptotic checking methods with each other and assayed the advantages and faults of HE and TUNEL in apoptotic checking. It also expounded the relationship of apoptosis to AID, tumor virus infection, nervous system disease and injury of bloodless.


Changes in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal or (during mitosis) whole genome level. The study of mechanisms leading to genotoxicity is crucially important, as well as the detection of potentially genotoxic compounds. We consider the current state of the art and describe here the main endpoints applied in standard human in vitro models as well as new advanced 3D models that are closer to the in vivo situation. We performed a literature review of in vitro studies published from 2000–2020 (August) dedicated to the genotoxicity of nanomaterials (NMs) in new models. Methods suitable for detection of genotoxicity of NMs will be presented with a focus on advances in miniaturization, organ-on-a-chip and high throughput methods.


The ability to accurately measure long-term time-series of tidal currents in bays and estuaries is critical in estuarine hydrodynamic studies. Accurate measurements of tidal currents near the air-water interface and in the bottom boundary layer remain difficult in spite of the significant advances in technology for measuring tidal currents which have been achieved in recent years. One of the objectives of this study is to demonstrate that turbulent mean velocity distribution within the bottom boundary layer can be determined accurately by using a broad-band acoustic Doppler current profiler (BB-ADCP). A suite of instruments, including two BB-ADCPs and four electromagnetic (EM) current meters was deployed in San Francisco Bay, California in an investigation of resuspension and transport of sediment during March 1995. The velocity measurements obtained in the bottom boundary layer by BB-ADCP were highly coherent (r2>0.94) with the velocity measurements obtained by EM current meters. During early March 1995, both BB-ADCPs and EM current meters recorded a very unusual flow event. Agreement among independent measurements by these instruments in describing such an atypical hydrodynamic occurrence further validates the velocity measurements obtained by BB-ADCP in the bottom boundary layer.


At the University of San Diego (USD), Industrial and System Engineering (ISE) students are required to take an Introduction to Systems Engineering course. The course material includes the introduction to the theory and methods used for problem identification, description, modeling, solution and implementation using the principles of the system development life-cycle (SDLC). To make the material meaningful the students need to apply the knowledge and information learned in the classroom in a real world environment. Service-Learning provides a "hands-on" opportunity for students to develop these skills. In the Fall of 2000, a community service project was identified with the Business Process Redesign (BPR) group at University of San Diego (USD). The Oracle corporation is implementing new a enterprise resource planning system throughout USD. The Business Process Redesign group assists each department at USD in defining and documenting of their current as-is processes because the departments are overwhelmed with current day-to-day operations and do not have the time or expertise to document their current processes. During Fall 2000 and Fall 2001, ISE students enrolled in the Introduction to Systems Engineering course, acting as external consultants, have provided the necessary resources for the BPR group to assist the departments. The result has been a win-win-win situation for all participants. The participating departments at USD win by having their processes documented by an unbiased consultant. The students win by applying textbook knowledge and by being exposed to a broader knowledge of professionalism and ethics than from textbook exercises. The ISE program wins through visibility across campus. This paper presents details on how we implemented the service-learning projects in the Introduction to Systems Engineering course. The benefits of service-learning for students and clients are discussed along with their assessments of the overall process. Finally, suggestions for identifying and implementing service-learning are discussed.


The graduates as the scholarly outputs are the key features managing the department of higher education. The department's graduation success is by fulfilling the expected graduation criteria, including education, research, and community service. This research aimed to study the efforts of the department to maintain the quality of the graduates by implementing a risk management approach. The research methods used were qualitative and quantitative, used collectively. The data was collected by interview, observation, documentation, and questionnaires; then, data analysis was carried out using inductive and descriptive quantitative data analysis techniques. The study was conducted in the magister Islamic studies program of Universitas Ahmad Dahlan Yogyakarta. Data were obtained from the department managers, which included 57 active students out of 87 students while the research was conducted in progress. The research results show that qualified graduates who meet graduation criteria are the risk the department faces. The efforts to maintain student graduation were achieved by a risk management approach and the steps of risk identification, risk assessment, risk placement, risk reviewing, and reporting. Risk management contributed to minimizing the risk of ungraduated students. Moreover, a risk management approach becomes necessary to prevent failure to achieve the planned quality objectives.


NHS England identified Patient Initiated Follow Up (PIFU) as part of NHS COVID-19 recovery, in line with the personalised-care agenda. We aimed to assess how the introduction of PIFU for neurology patients at Croydon University Hospital (CUH) has impacted patient outcomes, capacity and non-elective admissions. Data were extracted from electronic records on all patients booked into a CUH neurology PIFU appoint- ment from 1st June to 29th October 2021. Data were collected on the number of admissions or outpatient attendances for 5 years pre-PIFU appointment and compared with 0-6 months post-PIFU. 355 patients had a PIFU appointment at CUH neurology between 1st June and 29th October 2021. The most common neurological conditions prompting a PIFU appointment were epilepsy (40%), multiple sclerosis (22%) and Parkinson's disease (12%). The average number of outpatient appointments reduced from 11.0 pre-PIFU to 1.5 post-PIFU. The average number of ED attendances reduced from 3.1 pre-PIFU to 0.4 post-PIFU. Although there are significant limitations in this study (inadequate time since appointment, the pandemic), we remain keen on PIFU and had been running an advice line service before it was labelled as PIFU. Further follow-up data and patient satisfaction data is needed.


South Australia's Cannabis Expiation Notice (CEN) scheme, introduced in 1987, enabled adults possessing, cultivating or using small amounts of cannabis in private to avoid formal prosecution and the possible conviction by paying an expiation fee. The system attracted considerable criticism when first introduced. Some in the criminal justice sector thought the approach would prove unworkable. The paper summarizes a 1997 study of criminal justice attitudes toward the CEN system. Data were collected from 50 people via one-to-one interviews and focus-group discussions. Most respondents were from South Australia Police, but members of the judiciary and representatives of other government departments were also interviewed. Overall, this research indicated that the criminal justice sector was satisfied with expiation and saw no need to revert to prosecution of minor cannabis offenders. Drug Task Force and other detectives were concerned, however, about the provision for up to 10 plants in cultivation being expia...


Quality of life of cancer patients is one of the key parameters of analyzing treatment results and a criterion of treatment effectiveness. Immunomodulator "Polyoxidonium" has immunostimulating, membrane stabilizing, anti-oxidation function and can restore immune reactions. The tool for assessment of patient quality of life was questionnaire FACT-G including 27 main questions that assess four spheres of patient's life and 16 additional questions, which characterize toxicity of chemotherapy schemes. Treatment schemes applied for the patients resulted in improvement of main and additional parameters for breast cancer patients' quality of life.


Introduction: Huntington's disease (HD) is an inherited progressive neurodegenerative disorder which affects motor function, cognition and the psychological state of HD patients. Its triad of unique symptoms compared to other neurodegenerative disorders might give rise to a higher level of burden for their carers. The aim of this study was to explore factors associated with the quality of life in patients with HD. Materials and Method: Eighty-one HD patients and their carers participated in this study. Cognitive impairment was assessed with the Neuropsychiatry Unit Cognitive Assessment Tool (NUCOG), motor disturbances was scored using the Unified Huntington's Disease Rating Scale (UHDRS) motor scale, psychological status of both patient and carer were assessed using the Depression Anxiety Stress scale (DASS21), behavior of the patient was assessed using Revised Cambridge Behavioural Inventory (CBI-r) and patient's quality of life was assessed with WHOQOL-BREF questionnaire. Results: Patients' psychological conditions, motor disturbances and behavior of the patient are correlated with low QOL in HD patient. Conclusion: Other than regular motor symptoms, psychological and behaviour of HD assessment should be assessed regularly to ensure the patients having good quality of life.


The invention provides a chip packaging component and a manufacturing method thereof. The chip packaging component comprises a substrate, a chip, an adhesive layer and a packaging layer, wherein a convex pattern and a concave pattern are formed on a first surface of the chip, and the first surface faces to the substrate; the adhesive layer is arranged between the substrate and the first surface of the chip and is filled in the concave pattern of the first surface, and the first layer of the adhesive layer is adhered onto the substrate through the adhesive layer; and the packaging layer is used for packaging and protecting the chip and the substrate. According to the chip encapsulating component and the manufacturing method thereof, as the convex pattern and the concave pattern are formed on one side surface of the chip combined with the substrate, under the situation that the chip is adhered onto the substrate through the adhesive layer, an adhesive material can be filled in the concave pattern to reduce the height of the adhesive layer, so that the miniaturization of the encapsulating component is realized. In addition, as the adhesive material is filled in the concave pattern, the contact surface between the chip and the adhesive material can be increased, so that the heat radiation effect of the chip can be improved.


The following notes comparing the styles of William M. Harnett and John F. Peto are based on study of the voluminous material on the two painters assembled by Alfred Frankenstein, and on examination of a number of their paintings and of the scientific data on them gathered by Sheldon Keck (see this issue, pp. 38–56). In both cases the comparison is of their mature and not their early work.


The distributions of charged particles from heavy ion collisions have been measured by the PHOBOS collaboration. Results from Au+Au collisions at various energies and over a broad range of centrality are presented and discussed. This data are compared to p+p, d+Au and Cu+Cu collisions at the corresponding energy and centrality.


The role and place of volunteer practice in the process of professional training of "Social work" program students
have been considered. The main tasks and forms of volunteers practice making – of future social workers have been
characterized and its impact on the process of professional development of future social workers, aspects of involving
students in volunteer work in their spare time have been revealed; forms of future social workers tovolunteer as
organizers of volunteering have been disclosed.
Key words: volunteering, volunteers, social workers, vocational training, voluntary practice.


This paper summarizes the application of software packages such as Mathcad and MATLAB in system simulations of communication and radar systems. With the help of the software packages, little time was spent on computer programming; nearly all the energy was concentrated on the analyses of the fundamental theory behind the simulations.


A study was conducted during 1996-97 on the effect of sowing date on grain and fodder production among 21 selected lines of barnyard millet [Echinochloa crus.galli (L.) p, Beauv. ssp utilis] cultivars at an altitude of 2 100 m above mean sea-level on 3 sowing dates in April, May and June respectively. Sub-optimal temperature during vegetative period at sowing date in April and May delayed the initiation of flowering. On the contrary, an early tennination of growing season and prolong duration of grain filling was observed in June sowing at an exposure to low atmospheric temperature at post-floral growth of crop. Cultivars sown in April gave maximum grain and fodder yield. Correlation and path analysis suggested that sowing condition in April was more effective for greater exploitation of both grain and fodder yield of cultivars Under high hill condition.


The amendment of the Factories and Machinery Act 1967 (FMA) in 2006, with the inclusion of the new provision on special scheme of inspection takes into account of the development and advancement of technology, particularly on the latest procedure of inspection of plant and machinery in the Malaysian industries. The FMA since 1967 is the safety at work legislation applicable in Malaysia that provides for the control of factories with respect to matters relating to safety, health and welfare of person therein, the registration and inspection of machinery and for matters connected therewith. Inclusion of such provision provides an option to the industry to conduct its special scheme of inspection that analyzes the likelihood of failure and the consequence of the same in its work. This is obviously important for the economic benefits as the implementation of the scheme safeguards the integrity of the plant that will eventually increase the industry productivity and competitiveness. This paper discusses the importance of the inclusion of the special scheme of inspection provision into the statute and how it regulates the implementation of the system in the light of the development of technology in the industry. Analysis was made based on the latest legal documentation enforced relating to special scheme of inspection and with the coming into force of the Factories and Machinery (Special Scheme of Inspection) (Risk-Based Inspection) Regulations on June 1, 2014, the provision under the Factories and Machinery (Amendment) Act 2006 on special scheme of inspection shall now be fully implemented to see the effectiveness of the inspection approach for plant equipment using 'risks analysis'.


1. Interposer for stacked containers comprising a central flat body (1), lateral wings (2) on the sides of the central flat body (1) and perpendicular to said central flat body (1), a plurality of flanges (3 ) opposite to the side flaps (2) comprising at least one reinforcement (4) linked to at least two lateral flaps (2) so that the side flaps (2) are joined together and located in a position perpendicular to the body center plane (1). 2. Inserter for stacked containers according to claim 1, wherein the reinforcement (4) is a flat body with two wings at right angles to each other. 3. interposer stacked containers according to the preceding claims, wherein the reinforcement (4) has a height at least equal to the side flaps (2). 4. Interposer for stacked containers according to the preceding claims, wherein the reinforcement (4) is positioned inside the side flaps (2). 5. Interposer stacked containers according to claims 1 to 3, wherein the reinforcement (4) is positioned outside the side flaps (2). 6. interposer stacked containers according to the preceding claims, wherein the reinforcement (4) is of a material choice of plastic, metal and combination thereof.


Objective To establish the optimum polymorphism(AFLP) analysis system for amplified fragment length and silver staining system for Polygonum multiflorum Thunb.Methods The improved method of CTAB-DNA isolation was used to extract total DNA from Polygonum multiflorum Thunb.Several factors including the quantity and time for digested DNA were investigated and orthogonal test was used to optimize the system of pre-amplification and selective amplification.Results 400 ng DNA were digested with restriction enzymes at 37 ℃ about 5 h.The sharp fingerprint patterns were obtained by 6% denatured acrvlamide/bisacrvlimade gels electrophoresis with the AFLP silver-staining using the optimized system of pre-amplification and selective amplification.Conclusion The AFLP reaction system could be used to identify the species and local populations for Polygonum multiflorum Thunb.with efficiency,strong stability and reliability.


Abstract : This thesis addresses the issue of optimal budget allocation in the modernization of the U.S. Army's Light Tactical Wheeled Vehicles (LTWV). To achieve the objective for this research, a decision optimization tool was requested by the U.S. Tank-Automotive and Armaments Life Cycle Management Command (TACOM LCMC) and Program Executive Office, Combat Support / Combat Service Support (PEO CS/CSS) to provide an analytical tool to serve as the underpinning for modernization strategies for the LTWV over the next fifteen fiscal years. The optimization tool was implemented in Excel, using Excel Premium Solver Platform as the solver engine. An initial analysis was done to demonstrate the validity of the model, using notional data and the weighted values from the Value Model. Sensitivity analyses were also performed on the model by varying the inputs, such as the budgetary and average age requirements, to look at the capabilities that can be provided during the modernization period.


Houston, Saori M. MA, Purdue University, May 2016. A Longitudinal Study of Development of Fluency of Novice Japanese Learners: Analysis Using Objective Measures. Major Professor: Atsushi Fukada. Fluency has been studied extensively in ESL and EFL mainly to determine what spoken features are characteristics of fluent speech by comparing students who participated in study abroad programs with those who did not. These studies were mainly done with advanced learners of English as a second or foreign language, and there have not been many studies conducted with novice-level learners of foreign languages. Japanese fluency studies are especially in the minority. It is necessary to investigate the characteristics of fluency in Japanese novice-level learners since Japanese shares very little in common with English. This study investigated the developmental changes in fluency in Japanese foreign language learners (JFL) over the course of one semester using objective measures. Research questions are 1) which objective measures change in relationship to changes in L2 general proficiency throughout a semester, and how do they change, 2) Which objective measures correlate to subjective rating obtained from Japanese instructors?


To develop a scalable face image restitution system we apply Attribute-Enhanced Sparse Code words on local features extracted from face images combining with inverted indexing to construct an efficient and scalable face retrieval system. Nowadays Photos with people are the major interest of users. Among all those photos, a big percentage of them are photos with human faces. The importance and the sheer amount of human face photos make manipulations (e.g., search and mining) of large-scale human face images a really important research problem and enable many real world applications. Thus, with the exponentially growing photos, large-scale content-based face image retrieval is an enabling technology for many emerging applications. To utilize automatically detected human attributes that contain semantic cues of the face photos to improve content based face retrieval by constructing semantic code words for efficient large-scale face retrieval. By leveraging human attributes in a scalable and systematic framework, we propose two orthogonal methods named attribute-enhanced sparse coding and attribute embedded inverted indexing to improve the face retrieval in the offline database. We investigate the effectiveness of different attributes and vital factors essential for face retrieval.


The present invention includes two human comprising the immunoglobulin loci, wherein one of the two human immunoglobulin loci is a human heavy chain loci and the other of the locus is a human light chain loci, only one of the loci excluding humans a transchromosomic It provides transgenic mammals (preferably rodents). In transgenic mammal, except for some human transchromosomic is a self-replicating type. In transgenic mammal, except for some human and transchromosomic comprises a single human chromosome 14 fragment. In transgenic mammal, except for some human, a human light chain locus is associated with endogenous mammalian chromosome. In transgenic mammals except some humans, the human heavy chain locus is contained in a transchromosomic human light chain locus is associated with endogenous mammalian chromosome. In such transgenic mammals, other than humans, such as a few, at least a portion of the human light chain locus is cloned into a YAC vector. In transgenic mammals except some humans, the human heavy chain locus is included in hCF (SC20), a human light chain locus is included in the human kappa light chain locus transgene KCo5. In transgenic mammal, except for some human, a human light chain locus is contained in a transchromosomic human heavy chain locus is associated with endogenous mammalian chromosome. The transgenic mammals (e.g., mouse) non-human, the endogenous mammalian heavy chain locus and at least one mammalian light chain locus and endogenous mammalian heavy chain locus and kappa light chain locus is inactivated. Transgenic mammal, except a human, the human sequence antibodies, transchromosomic, heavy chain, light chain


With SeCuUI we present a solution that aims to increase security of data entry on public terminals. The user can enter all data requested by the terminal using her mobile device. Sensitive data can be hidden from prying eyes by exclusively showing it on the user's mobile. To speed up the whole process, the SeCuUI-client stores previously entered data on the mobile device to provide auto form filling capabilities.


The Kiskendo Cave System is a system that has many benefits, including as a tourist site and water source. One of the systems in the upstream of Kiskendo Cave is the Semar-Kiskendo Caves system. This system is estimated to greatly affect the condition of the Kiskendo cave system because it is connected to the allogenic river which contributes to recharge from outside Jonggrangan Karst Area. The purpose of this research was 1) to find out the characteristics of the Semar Cave cavities and 2) to analyze the connectivity and characteristics of cavities in the Semar - Kiskendo Caves system. This research employed a survey method by mapping the cave to answer the first problem and conducting a tracer test of underground river stream to answer the second problem. The results showed that the Semar Cave cavity that could be mapped was 158.2 meters long, the total volume of the cave was 1,220.6 m3, and the average diameter of the cave cavity was 2.8 meters. The results of second study using the tracer test showed the connection between Semar Cave and the underground river in Kiskendo Cave, and the cavities had a characteristic of a single conduit which was sufficiently developed.


This article explores the vocational psychology of lesbians. Identity and work are assumed to be interrelated elements of the self, and a continuum from invisibility to integration captures two critical aspects of a consideration of lesbian identity in the workplace. First, it characterizes the range of responses lesbians use in resolving the core dilemma of how to manage their identities as lesbian workers. Second, it describes a needed progression in the career development literature, in which consideration of lesbian workers becomes an integral part of vocational pychology. This article begins with a brief review of the literature in lesbian and women's identity development, to lay a foundation for the discussion of vocational issues facing lesbians that follows. It then concludes with suggestions for fture theoretical and empirical efforts, as well as implications of this work for vocational counseling. IDENTITY DEVELOPMENT OF LESBIANS Gelso and Fassinger(1992) pointed out the developmental underpinnings of all major theories of vocational behavior, in that the formation of an occupational self encompasses intrapsychic, personality (trait), cognitive, learning, and environmental aspects through complex, dynamic interactional processes over time in relatively predictable sequences. Other identity development trajectories--sexual, racial and ethnic, gender, and others--are thus inextricably interwoven with the development of a vocational identity. In addition, for development taking place under oppreasive conditions (racism and xenophobia, sexism and patriarchy, heterosexism and homophobia), theoretical frameworks assume the primacy of those oppressive influences on a normative psychological process of group or cultural self-definition (c.f. Allport, 1954; see Fassinger & Schlossberg, 1992; Gonsiorek & Rudolph, 1991). Most of these models postulate a sequence of stages that must be negotiated in moving through processes of awareness, exploration and understanding, attitudinal change, identification, and integration regarding one's status as a member of an oppressed group in relation to the dominant culture. Most salient in exploring the vocational psychology of lesbians are developmental models and concepts related to gender and sexual orientation. It has often been suggested in the lesbian and gay identity development literature that important differences between men and women are likely to influence the identity formation process, and yet much of the existing literature does not address these differences. Most of the well-known identity models have been developed based on the experiences of gay men and then generalized to lesbians, or they represent syntheses of existing models into simplified frameworks and, thus, also present predominantly androcentric perspectives on development (McCarn & Fassinger, in press). But influences on women's development such as gender role socialization (particularly regarding the formation of relational identities and the interconnection of intimacy and autonomy), the repression of sexual desire, and the advent of feminism (and its concomitant reinforcement of nonstereotypic gender roles) have been indicated as factors likely to create a unique context for the formation of lesbian identity (McCarn & Fassinger, in press). For example, much has been written regarding the expression and repression of women's sexuality and the complex interconnection between intimacy and autonomy both in lesbian and in heterosexual women (e.g., Butler, 1993; Daniluk, 1993; Fassinger & Morrow, in press; Frye, 1992; Garner, Kahane, & Sprengnether, 1985; Gilligan, 1982; Peck, 1986; Vance, 1984). Interwoven intimacy and autonomy processes, as manifested in lesbian identity development, suggest that women would be likely to "come out" in the context of a relationship, rather than through articulating and acting on sexual desire alone. This, in turn, would predict a lengthy process of questioning and exploration in women, because it is partly subject to the behavior of intimate others (McCarn & Fassinger, in press). …


This paper analyses all influence factors of channel patterns and definite that boundary conditions of river channel,water and sediment conditions are major requirement of formation and transformation to channel patterns.Channel patterns are divided into six grades and quantified coding.Equation of differentiating channel patterns is put forward based on data of 12 rivers by multiple linear regression equations,and Cp standard.The conclusion can be draw that the most important factor of channel patterns is boundary conditions of river channel,the second is water conditions,the third is sediment conditions.


Thank you very much for reading theories and methods of group counseling inthe schools. As you may know, people have look numerous times for their chosen readings like this theories and methods of group counseling inthe schools, but end up in malicious downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they juggled with some malicious bugs inside their laptop.


* Please see http://CRUSER.nps.edu for additional details on concepts *Please note: abstracts should be 300-500 words Due by 1 March to email@example.com NPS CRUSER Technical Continuum 11-12 April 2017 Autonomous USV Missions Other Robotics or Autonomy topic Calhoun: The NPS Institutional Archive


We present a symbolic approach to the calculation of siphons and traps for algebraic Petri nets where the color domains are speci ed without equations and with at most unary operation symbols


Significant oral function is often lost after surgical therapy for head and neck cancer. The use of osseointegrated implants for reconstruction in patients with head and neck surgery has shown to significantly improve the quality of life for these patients. Variable success rates range from 99% to 70%.


Avulsion fractures of the pelvis occur in both the skeletally immature and adult patient populations the patho-mechanism is the sudden forceful contraction of the related muscle. The case reported here is an overlooked case of anterior inferior iliac spine avulsion fracture in a 25-year-old man, misinterpreted as malignant pathology. Avulsion fractures of the anterior inferior iliac spine can be diagnosed with medical history and radiological methods. The physician must be cautious during the assessment of the patient with complaint in his/her groin and keep in mind the possibility of an anterior inferior iliac spine fracture.


The quality of high-voltage protection running,not only on high-frequency protection device itself,at the same time depends largely on the work of high-frequency channel.Analyzing the composition of the high-frequency channel and the type of high-frequency channels,for different failure,adopting different treatment methods;failure of high-frequency channel should be first out of high-frequency protection,and then proceed to the inspection and processing channels.


The authors studied the duration of action of vecuronium in 15 patients with normal renal function and 40 patients with chronic renal failure to evaluate the effect of secondary hyperparathyroidism on the action of vecuronium. The patients were divided into four groups: 15 patients with normal renal function (Group A); nine patients with chronic renal failure who did not need haemodialysis (Group B); 15 anephric patients who did not require parathyroidectomy (Group C); and 16 anephrenic patients who underwent parathyroidectomy because o f severe secondary hyperparathyroidism (Group D). The ratio o f the height o f the first twitch (T1) to the baseline value before vecuronium administration was measured by an electromyogram. 'Baseline T 1 was obtained after anaesthesia induction with thiamylal iv. The time to 10% recovery o f the first twitch (REC 10) after administration of vecuronium 0.12 mg. kg -1 iv was measured in each group. Anaesthesia was maintained with isoflurane and nitrous oxide in oxygen, and supplemented with fentanyl iv. Patients in Group D showed shorter REC 10 (51 + 4 rain) than those in Groups B (71 + 6 rain) and C (80 • 10 min) (P < 0.05), but similar REC 10 to patients in Group A (37 + 4 min). These results suggest that the duration of action of vecuronium in anephrie patients with secondary hyperparathyroidism is shorter than in those without secondary hyperparathyroidism.


This work presents the direct current control scheme of shunt active power filter with an LCL output filter of a single phase energy distribution system feeding nonlinear loads connected at the PCC using an LQR. The model of SAPF-LCL is carried out in D-Q frame and the controller with added integral action is designed to compensate harmonics of the nonlinear loads and to keep the DC bus voltage at its reference value. Simulation and preliminary experimental results carried out confirmed the best performance in steady state of the implemented controller and the good tracking in dynamic regime to load and source voltage variations and robustness to large variation of source inductance.


We found no controlled trials evaluating the efficacy of changing formulas in the management of uncomplicated regurgitation. However, the evidence suggests that no benefit can be expected from changing formulas, including the discontinuation of iron-fortified formulas. 1,2 Additionally, changing formulas leads many mothers to believe that their child has a disease or illness. 3 Although controlled trials of infants with gastroesophageal reflux disease (GERD) show that formula thickening (eg, with rice cereal) decreases spitting-up, 4 and expert consensus panels recommend formula thickening (along with parental reassurance) as first-line therapy in the management of uncomplicated regurgitaion, 5 one could question whether these outcomes in infants with GERD would hold for infants with uncomplicated regurgitation. Flat-prone positioning and avoiding the seated position is beneficial in infants with GERD, but the association of prone positioning with sudden infant death syndrome limits this intervention. 5 (Grade of recommendation: D, based on a synthesis of information from controlled trials performed in other patient populations, retrospective surveys, physiologic evidence, and consensus expert opinion.)


There are various ways through which we try to capture another person's attention. One of these ways is to address them. After trying to highlight what it is to address another person, the chapter argues that doing so generates a reason (for you, as addressee) to attend to the act. When the act of address is a speech act, matters are further complicated by the expectations parties bring, and are entitled to bring, to an (anticipated) speech exchange. If this is correct, then the act of address itself generates the most basic form of conversational pressure: in cooperative exchanges speakers who address an audience have a claim on the audience's attention. To fail to attend to a speaker who addresses you and whose claim on your attention is part of a (would-be) cooperative exchange, the chapter argues, is to disrespect her as a rational subject.


I studied local divergence in growth, a trait previously shown to be both phenotypically plastic and heritable, among wood frog (Lithobates sylvaticus (LeConte, 1825)) tadpoles inhabiting four ponds within a continuous woodland. Mark–recapture results revealed very low levels of migration among ponds as close as 35 m and no more than 185 m apart. Common garden experiments conducted at two temperatures revealed consistent year-to-year patterns of phenotypic divergence in tadpole growth performance among the four pond populations. The divergence in growth performance was conserved when controlling for parental effects via half-sibling experiments. Results of cross-transplant experiments suggest that the divergence in tadpole growth reflected either genetic drift or adaptation to local pond conditions. Taken together, the results suggest that divergence in growth performance among the tadpoles from the four ponds is the result of selection or genetic drift reinforced by low levels of gene flow among pond pop...


Patients with glycogen storage disease (GSD) type lb show normal activity of glucose-6-phosphatase (EC18.104.22.168) as assayed in frozen liver, though their clinical and biochemical findings are similar to those of patients with GSD la (McKusick 23220). In 1978, we demonstrated that a basic defect ofGSD lb exists in the glucose-6-phosphate (G6P) transport system of microsomat membranes (Narisawa et al., 1978; Igarashi et aL, 1979). Subsequently our findings were confirmed by others (Beaudet et al., 1980; Lange et al., 1980; Corbeel et al., 1981; Schaub et al., 1981). In this paper, the basic defect in GSD type lb was investigated in two patients; one with severe and the other with mild clinical symptoms. METHODS


The aim of this study was to identify the eggs of helminths in the faeces of Alces alces, Cervus elaphus and Capreolus capreolus in Lithuania. The modified method of McMaster and the sedimentation technique were applied.110 samples of faeces were collected including 20 samples of elk, 30 samples of roe deer and 60 of red deer (30 of farmed and 30 of wild red deer) and investigated for the presence of helminth endoparasite eggs. 100% of the samples studied showed nematodes and/or trematodes eggs. The following species were found: Paramphistomum cervi (10 of the Cervidae faeces positive), Dicrocoelium dendriticum (45), Strongyloides papilosus (60), Trichuris ovis (5), Capillaria sp. (19), Nematodirus sp. (36) and Strongylidae (25). P. cervi, D. dendriticum, S. papilosus and Strongylidae were found in all three cervid species. Cappilaria sp. was common only in red deer. The presence of T. ovis eggs was found at various distribution rates in elk and roe deer faeces. The eggs of Nematodirus sp. were identified in elk and red deer faeces. The wild and farmed red deer demonstrated the same helminths species. There were maximum numbers of helminths eggs per gram in the samples of farmed red deer faeces.


Attention-deficit hyperactivity disorder (ADHD) is a heterogeneous, long-course neurodevelopmental disorder with a strong genetic component . Children and adolescents with ADHD frequently have cooccurring conditions, such as depression, bipolar disorder, anxiety, and learning disabilities . The neuropsychological problems associated with ADHD in children have been well documented, and typically are characterized as core deficits in attention and executive functioning . Those with comorbid learning disabilities often have more pronounced neuropsychological deficits .