Objective: To observe the ef ects of ZuogufiJiangtang Yishen Decoction(ZJYD) on blood glucose, blood lipids, renal function, serum inflammatory factors of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in MKR mice with diabetic nephropathy. Method: 8 weeks of MKR mice, which were dominant-negative insulin-like growth factor-1 receptor specifically targeted to the skeletal muscle were randomly divided into 5 groups: control group, high fat diet feed group, high-fat diet feed and mono-nephrectomy model group, ZJYD group, and positive control group(PCG), according to sex, fasting bloodglucose and body weight; 15 mice in each group. Fifteen C57 mice was as normal group. Four weeks after operation, the mice were gavaged for 30 days of ZJYD of 14.4g/kg; observing the fasting blood-glucose and blood lipids, renal function, serum contents of TNF-α and IL-6. Results: Compared to model group, ZJYD can low the fasting blood-glucose and blood lipids, improve the renal function, low the serum contents of TNF-α and IL-6, with significant differences(P 0.05, P 0.01). Compared with the positive control, the ef ect of lowing the content of IL-6 was superior to PCG; and the ef ect of improving the renal function, lowing serum content of TNF-α and blood lipids was as good as PCG; but the ef ect of lowing blood glucose was inferiorto PCG. Conclusion: The ZJYD of 14.4g/kg have good results of improving the renal function, lowing serum content of TNF-α and IL-6 and blood lipids of diabetic nephropathy in MKR mice.


North Korea has plutonium enough for 3 to 6 nuclear bombs. It has successfully weaponized the nuclear devices. And it "may be able to successfully mate a nuclear warhead to a ballistic missile." North Korea has deployed some 320 No Dong with the range of 1,300 kilometers, the payload of 1,000 kilograms, and circular error probable (CEP) of 2.5 kilometers, so it "may be able to" use nuclear weapons against Japan today. There are two scenarios in which North Korea might launch missiles against Japan. One is a military-diplomatic scenario in which North Korea would launch missiles as a part of its effort to normalize relations with Japan. The other is a scenario in which desperate North Korean leaders launch all-out attacks against Japan. Japanese response to North Korea's potential nuclear armament is twofold: military response and diplomatic response. As it is difficult to spot and destroy No Dong missiles on the ground, ballistic missile defense (BMD) and civil defense are the most important means of coping with missile attacks. In addition, an option to possess limited strike capabilities to conduct counterforce operations against North Korean missiles and missile bases is widely debated. Japan and North Korea took steps to improve their relations in 2008. The NorthKorean side promised to conduct comprehensive investigations on the abduction issue, and the Japanese side agreed to lift its ban on travels to and from North Korea as well as charted flights between the two countries when the investigation started. However, when Prime Minister Fukuda resigned in September, North Korea unilaterally suspended the implementation of the agreements. Japan-North Korea bilateral relations have stalled since then.


The article is devoted to communicative failures considered as different kinds of discomfort in the process of natural dialogic communication, in intercultural communication which occupies a special place in the modern communication space. It is stressed that any culture has its norms and rules of behavior, its discourse style "manner of speech" of its representatives, speech conventions upon which the admitted forms of socio-important meanings depend. At the implementation of communicative intentions in intercultural communication, it is necessary to have the knowledge of cultural peculiarities and differences, cultural traditions and mentality of communicating people and of those strategies which minimize communicative failures.


In this study, we revisit the security models divided by the potential adversaries according to their attack power of certificateless signatures. Since certificateless signature(CLS) scheme's introduction in 2003, there have been quite a number of CLS schemes proposed [1–9,11,12]. However, only few schemes are known to be secure against these adversaries. Some schemes are insecure against a type I adversary who can replace a user's public key and against a type II adversary who can access to the master secret key of the system, separately. In this talk, we classify attacks according to their attack power of certificateless signatures and consider the certificateless cryptosystems used for designing certificateless signatures with additional functionality.


Infrastructure projects are the backbone of the economy of the developed counties. Gaza Strip is suffering from non-prioritization of infrastructure project implementation. The objective of this paper was to identify the causes of non-prioritization infrastructure projects in the Gaza Strip. This paper considers the key causes of non-prioritizing infrastructure projects in Gaza Strip. Using an empirical questionnaire survey targeting groups consist of 5 ministries, 25 municipalities, 25 NGOs, international agencies and 59 consultancy firms working in Gaza Strip, respondents were invited to rate the level of importance of 52 causes have been finalized to be involved in this study from the literature. Results revealed that the most important causes are related to the project and its location, the surrounded political and economic environment, donors and project's owner. There is no consideration for local needs in the implementation of the infrastructure projects in the Gaza Strip and there are problems in the process of selecting infrastructure projects priorities by owners of these projects. Furthermore, several donors placing limitations on the type of infrastructure that it can support that related to their working area of aids and according to their political directions. Finally, the political and economic situation in Gaza Strip, and imposed borders blockade affects the decision-making process for the selection of the proposed projects. This paper will help the decision makers to consider the important aspects that should be considered when planning to infrastructure projects.


These two volumes on Acts are part of the New Covenant Commentary Series (NCCS), which are designed for ministers and students and represent an international cast of contributors. These two volumes are by two Korean scholars from different theological backgrounds. Both volumes follow a similar structure. First, the authors offer their explanation of the text but not in the typical verse-by-verse commentary style. The authors demonstrate a more general and diverse approach, analysing key themes and ideas, covering major events happening in Acts, sometimes focusing on certain passages, phrases and words to make specific points. They engage with many Western scholars and major academic publications and journals. Second, the authors provide occasional reflections on how the text impacts and shapes the identity and mission of the church today. The character and content of these reflections differ. Cho's reflections in the first volume are about divine–human encounter. They carry spiritual implications, for example, about being filled with the divine power (p. 72), miraculous intervention of God in human affairs (p. 83), on God's divine grace at work (p. 121), suffering and being obedient to the Spirit (p. 168). Park reflects in the second volume on the sense of the community, for example, the Church's growth and development (p. 12), its unity and encouragement (p. 54), inclusiveness and absoluteness (p. 100), on the community being adjustable, vision-oriented, prayerful, etc. The first volume is preceded by an introduction that deals with typical preliminary matters. Both volumes engage with various historical, theological and compositional questions in relation to Acts, although they are not systematic or comprehensive. They are easy to follow and will be accessible to a variety of readers. I think that application sections will be of special interests to practitioners and to a wider audience in general.


Also Described on the back cover as a very personal account of the scientific dating of the Turin Shroud and its surrounding controversy is HARRY E. G ~ v E ' s Relic, icon or hoax? Carbon dating the Turin shroud. (xvi+336 pages, 16 colour plates, 22 illustrations. Bristol & Philadelphia (PA): Institute of Physics Publishing; 0-7503-0398-0 hardback L19.50). GOX? was one of the inventors of the Accelerator Mass Spectrometry dating technique. As we now know, the Shroud is revealed by GOVE as being of the Middle Ages, and possibly as an icon of rare genius in its production. At times it seems that contra all his rational feelings, GOVE was almost willing (or praying ?) for it to be of ancient date. J. HERMANN & E. ZURCHER (ed.). History of Humanity volume Ill. From the seventh century BC to the seventh century AD. xxx+682 pages, 193 plates, 58 figures, 48 maps. 1996. Paris &London: UNESCO & Routledge; 92-3-102812-X (UNESCO) & 0-415093 0 7-4 (Routledge) hardback €95.


As a result of globalization, automotive sector producers in Turkey have begun to manufacture vehicles for global markets. It becomes important in this uncertain environment to be armed with performer flexibility levers in order to deal with the rapid changes in the sector. The main objective of this study is to evaluate the Turkish automotive sectors' customer needs and then to designate the flexibility types and system factors, and to detail the flexibility types which will fulfill the customer requirements. For this purpose, as the methodology, a decision-making model is developed by combining the Fuzzy Analytical Hierarchy Process (FAHP) and House of Flexibility (HoF) derived from Quality Function Deployment (QFD). After a detailed literature survey and an intensive discussion with experts from automotive sector, the most important criteria which could be used in our methodology are defined. First, the customer needs for this sector are detailed and ranked via FAHP. Then a house of flexibility is constructed to relate customer needs with the flexibility levers. Later, a second house is built to detail down the flexibility levers into system factors. The aim is the right selection of the flexibility portfolio which will satisfy the needs of the Turkish automotive industry.


Rhynchosauria was an important clade of herbivorous archosauromorph reptiles during the Triassic, with a worldwide distribution. We describe a new genus and species of early rhynchosaur, Eohyosaurus wolvaardti gen. et sp. nov., from the early Middle Triassic (early Anisian) Cynognathus Assemblage Zone (Subzone B) of the Karoo Supergroup, South Africa. Eohyosaurus wolvaardti is known from a single skull, and is recovered as the sister taxon of Rhynchosauridae in a new phylogenetic analysis. Cynognathus Subzone B has previously yielded the stratigraphically oldest well-understood rhynchosaur species, Mesosuchus browni and Howesia browni. Eohyosaurus wolvaardti increases the rhynchosaur diversity within this stratigraphical horizon to three species. Intriguingly, all currently confirmed rhynchosaur occurrences from the Early Triassic to earliest Middle Triassic are from South Africa. This may suggest a relatively restricted palaeogeographical distribution for early rhynchosaurs, followed by a global dispersal of rhynchosaurids during the Middle Triassic. © 2015 The Linnean Society of London


A fast and stable method is proposed for calculating the time-varying shielding current density in a hightemperature superconducting (HTS) film containing cracks. If an initial-boundary-value problem of the shielding current density is formulated by the T-method, integral forms of Faraday's law on crack surfaces are also imposed as boundary conditions. As a result of the spatial discretization of the initial-boundary-value problem, semi-explicit differential algebraic equations (DAEs) are obtained. Although the DAEs can be solved with standard ordinary-differential-equation (ODE) solvers, much CPU time is required for their numerical solution. In order to shorten the CPU time, the following high-speed algorithm is proposed: the block LU decomposition is incorporated into function evaluations in ODE solvers. A numerical code is developed on the basis of the proposed algorithm and detectability of cracks by the scanning permanent-magnet method is numerically investigated. The results of computations show that, when multiple cracks is contained in an HTS film, resolution of the scanning permanent-magnet method will be degraded remarkably.


The aim of this paper was the assessment of nitrate (NO3 - ) and nitrite (NO2 - ) content in the mixed feeds and eggs from two different production systems (organic and conventional). Were analyzed 40 samples of mixed feed and lay eggs from Brown hybrid at the age of 27 weeks in two units in Romania. Sampling and the preparation of samples were performed in compliance with the rules of the standards in force in Romania and harmonized with EU legislation (SR 13175:1993); the method for the determination used was spectrophotocolorimetry method (UVmini 1240 SHIMADZU) . Analysis of mixed feed samples revealed statistically significant differences (p≥0.05) between the two systems (organic vs. conventional) for the nitrate content but significantly distinct (p≤0.01) for nitrite content (0.49 vs. 1.71 ppm relative to a feed with a moisture content of 12%), values well below the maximum allowable 15 ppm provided by legislation in Romania. In the case of the nitrate content of analyzed eggs, there were distinctly significant differences (p≤0.01) for whites samples (0.83 vs. 2.65 ppm fresh product) and mixtures samples (0.18 vs. 0.15 ppm fresh product) and statistically insignificant (p≥0.05) for yolk samples. In the case of nitrite content of eggs from the two production systems were very significant differences (p≤0.001) (0.16 ÷ 0.27 ppm vs.0.06 ÷ 0.22 ppm fresh product). Higher values of nitrite in eggs from organic systems may be due to access of poultry on grassy paddock and additional consumption of green fodder, its analysis revealed an average of 0.83 ppm at 12% moisture feed.


EnglishIntroduction: Circumference of the neck may be a possible measure for the identification of overweight in adults in clinical practice The objective was determined the cut-off points of neck circumference corresponding to excess weight levels classified by Body Mass Index (BMI). Method: Cross-sectional study, with adults patients, of both genders, attended in nutrition clinic of Sergipe University Hospital. Were collected waist circumference, neck circumference, body weight, height, the latter two used for the determination of BMI. Data were analyzed using the Mann-Whitney test and the correlation between the numerical variables by the Spearman test. The Receiver Operating Characteristic (ROC) curve was used to evaluate the predictive capacity of the neck circumference, as well as, the determination of the cut-off points of overweight or obesity (α = 5%). Results: A total of 323 subjects were evaluted, with a mean age of 40.9 (10.8) years, most (81%) women. For the male and female, respectivamente, neck circumference showed a strong correlation with body weight (r = 0.859, p portuguesIntroducao: A circunferencia do pescoco pode ser uma medida possivel para a identificacao do excesso de peso em adultos na pratica clinica. Objetivo: Determinar os pontos de corte da circunferencia do pescoco correspondentes aos niveis de excesso de peso classificados pelo Indice de Massa Corporal (IMC). Metodos: Estudo transversal, com pacientes adultos, ambos os sexos, atendidos no ambulatorio de nutricao do Hospital Universitario de Sergipe. Medidas antropometricas de circunferencia abdominal, circunferencia do pescoco, peso corporal e estatura foram aferidas, as duas ultimas utilizadas para o calculo do IMC. Os dados foram analisados usando o teste de Mann-Whitney e a correlacao entre as variaveis numericas pelo teste de Spearman. A curva ROC (Receiver Operating Characteristic) foi utilizada para avaliar a capacidade preditiva da circunferencia do pescoco, bem como, a determinacao dos pontos de corte de sobrepeso ou obesidade (α=5%). Resultados: Foram avaliados 323 individuos, com media de idade de 40,9 (10,8) anos, maioria (81%) mulheres. Para o sexo masculino e feminino, respectivamente, a circunferencia do pescoco mostrou forte correlacao com o peso corporal (r = 0,859; p


The authors investigated how normal subjects respond, in terms of the motion of their lower limbs, pelvis, and trunk, during level walking when fitted with mass-produced separated medial and lateral arms insoles. Three-dimensional gait analysis was performed on eight healthy male adults, fitted bilaterally with the tested orthosis. Eighteen spherical retroreflective skin-mounted markers were placed at specific anatomical points. Each participant performed six consecutive gait cycles at self-selected speed under three experimental conditions: barefoot, shod, and shod with insoles. Kinematic variables were then calculated and one-way analysis of variance and Tukey-Kramer multiple comparisons tests were performed to characterize the differences observed among the test conditions. When the separated-arms insoles were used, the kinematics of the lower limb joints, pelvis, and trunk at the sagittal plane were not significantly affected, with the exception of the ankle joint. At the frontal plane, significant differences were found for both the hip joint and trunk, whereas at the transverse plane, significant differences were found for the ankle-foot complex only. The ankle-foot motion at the frontal plane and the hip joint motion at the transverse plane were not analyzed because of a high level of noise. All subjects but one exhibited consistently lower gait cycle and stance phase duration and increased stride length, walking speed, and cadence when changing from the shod to the insole condition. Our results indicate that there are immediate effects of the separated-arms foot orthoses to the walking pattern of the examined group. However, the way these insoles affect the lower limbs, pelvis, and trunk regarding relief of pain and fatigue remains unclear.


Background: Fractures and dislocations are common orthopedic conditions arising from traumas from anthropic interaction on wild species, such as those caused by road trampling. Among the treatments, osteosynthesis is considered the method of choice in the treatment of fractures, such as ilium body fractures and femoral fractures. Based on this context, with regard to the incidence of auto accidents and few studies describing osteosynthesis techniques for crab-eating fox, the present study aimed to report the osteosynthesis performed on the body of the ileum and femur of a wild specimen of Cerdocyon thous.Case: A female, adult, crab-eating fox (Cerdocyon thous), coming from wild life was referred to hospital care with a history of run over. After specific examinations, it was diagnosed a complete transverse femoral shaft fracture, an oblique ilium body fracture, a pubic and ischial fracture, and pelvic canal narrowing. The treatment instituted was osteosynthesis of the femoral and ilium body fractures through the use of a 2.7 mm locking plate and screws. In the postoperative period, radiographic examination was performed, where bone callus formation was observed in the 5th week and bone remodeling and consolidation in the 11th week. After 140 days of rehabilitation, the animal was able to be released in the wild, with effective return of function of the pelvic limbs. The release was performed by environmental agencies in a national natural reserve, using radio necklace monitoring.Discussion: Osteosynthesis techniques and preoperative and postoperative management proved to be effective for the return of adequate function of the pelvic limbs in Cerdocyon thous. For wild animals, the use of internal orthopedic implants (plate and screws, for example) become the most suitable for osteosynthesis. They decrease the risks of complications resulting from the management, since they require minimal postoperative manipulation. Thus, they maintain the wild behavior of the animal even in captivity. Among the complications observed in the clinical case, we can mention the use of long plate in the osteosynthesis of the ilium body and the narrowing of the pelvic canal as the most relevant. In relation to the pelvic canal narrowing and the reproductive cycle of the species, the crab-eating fox presents monogamous behavior, gestation of 3 to 6 pups per litter and breastfeeding for approximately 3 months. Because litters are relatively large (number of individuals per calving), the pups are relatively small - approximately 120 g at birth -, so it is expected that no complications occur during the gestational period. The treatment of fractures with the use of locking plates was efficient, obtaining bone consolidation at 10 weeks postoperatively, thus corroborating the scientific descriptions for bone consolidation in canids. Finally, the destination for release and monitoring by radiotelemetry was a joint decision between the environmental agencies of the State and the Union. The release decision was based on the maintenance of the wild behavior without evidence of meekness of the specimen, the absence of sanitary restrictions, as well as the population biology and the genetic flow since the release of the animal was carried out near the rescue site. It is concluded that the surgical treatment instituted by the femoral and ilium osteosynthesis was effective for the Cerdocyon thous specimen, culminating in the rehabilitation of the animal and release in the wild.


An aqueous ink binder including 30-60%, by weight based on the dry weight of the binder composition, of a first polymer including, as polymerized units, 15-75%, by weight based on the weight of the first polymer, ethylenically unsaturated carboxylic acid monomer having a pKa from 2.0 to 4.6, the first polymer having a calculated Hansch parameter from 1.3 to 2.1, and 70-40%, by weight based on the dry weight of the binder composition, of a second polymer, the second polymer being an aqueous emulsion polymer is provided. Also provides are a clear or pigmented ink composition and a method for providing an ink which has press resolublility and, as a dry film, water resistance.


Abstract : The Korteweg-deVries and the Kadomtsev-Petviashvili (KP) equations both model the evolution of relatively long water waves of moderate amplitude as they propagate in shallow water. Both equations are completely integrable. In this paper we review the derivation of each equation as an approximate model of shallow water waves, and compare their solutions with some of the experimental observations of waves in shallow water. We also describe in detail the family of doubly periodic KP solutions. These are the natural two-dimensonal generalizations of cnoidal waves in one-dimensional; one may think of them as describing 'typical' patterns of nonlinear, two-dimensional waves in shallow water.


In a door closing procedure, an aircraft passenger door is pivoted from an open position to a pivoted-in position, shifted to a closed position, locked into a locked condition, and then Secured into a Secured locked condition. A control method and arrangement for controlling the closing proce dure includes Sensors that respectively each Sense the completion of a respective allocated one of the Steps of the (22) Filed: Jul. 31, 2001 closing procedure, and then responsively initiate the next following Step of the procedure. The closing procedure is (30) Foreign Application Priority Data carried out in an automatic Sequential Step-wise manner using a simple robust arrangement, without requiring a Aug. 2, 2000 (DE)..................................... 1OO 37 621.5 computer control.


During the last four decades, the management of hypertension has been enriched by the remarkable development of new, effective and well-tolerated antihypertensive drugs. The multiple clinical trials performed with these agents have provided compelling evidence that lowering blood pressure is a very effective way to reduce cardiovascular morbidity and mortality so that, today, hardly any physician would really dispute the need to treat hypertension. Yet, the numerous national or local surveys which have provided a critical appraisal of the quality of hypertension care have consistently demonstrated that the prevalence of patients with unknown hypertension and the percentage of treated hypertensive patients with an uncontrolled blood pressure remain high [1–6], despite all information strategies and the rapidly growing diffusion of national and international guidelines for the management of hypertension [7–10]. Thus, data from the National Health and Nutrition Examination Surveys in the USA show that the awareness of the hypertension population has improved from 50% in the 1970s to approximately 70% in the 1990s [1]. Over the same time, the percentage of treated hypertensive patients with a normal blood pressure has also increased from 10 to 29%, but the most recent survey has found a stabilization of these figures at 27% [1]. In Europe, several studies have reported a percentage of controlled blood pressure ranging between 6 and 30% [2–4,6].


Abstract Field-rearing studies of Camnula pellucida (Scudder) conducted at Saskatoon from 1960 to 1962 indicated that marked differences often occurred in rate of development, survival and fecundity because of differing weather patterns. Grasshoppers usually developed more rapidly as they hatched later in the season when temperatures were rising. In addition, striking differences occurred in growth rates of grasshoppers hatched on similar dates in different years due to sharply contrasting climatic conditions. Although survival of nymphs was generally high, mortality was consistently greatest during early nymphal life. Precipitation or excessively hot weather during this period increased mortality considerably, yet did not affect the older nymphs. Survival of adults was also generally high whether they fledged early or late in the season. They were able to endure very high temperatures during mid-summer or below freezing temperatures during late autumn. The three-year average reproductive capacity of this grasshopper was approximately eight egg-pods or 176 eggs per female. The rate of oviposition varied with temperature, reaching a maximum per female of approximately one pod every four days during mid-summer when temperatures were high and declining thereafter as temperatures dropped. The average egg-pod contained 22.13 eggs which showed a tendency to increase as adults fledged later in the season. It is suggested that climatic conditions frequently play a decisive role in the short-term modification of grasshopper infestations as well as in the long-term cyclic rise and fall in populations; consistently favourable or unfavourable conditions throughout the grasshopper cycle could result in an explosive outbreak or in almost complete elimination of any threat to the crop.


Software based musical instruments are new kind of musical instruments that employ digital technology in the generation of sound, user interface or both. In this work I describe a new software based musical instrument called Seq1 that was developed at the RFMedia laboratory in Ylivieska. Design choices for Seq1 came from findings in literature into similar phenomena. Research literature also unveiled the fact that although there are frameworks for describing different aspects of software based musical instruments there is no general model for classifying software based musical instruments. There are systems for classifying musical instruments such as the most prominent of these, the Hornbostel-Sachs system which is meant as a way to classify every type of musical instrument. It was originally created in 1914 and has since then been updated several times. The last update has been in 2011 which added tens of new subcategories for electrophones (electronic instruments). The subcategories meant for classifying software based musical instruments seem to be inadequate. This work introduces a sketch of a new model for classifying specifically software based musical instruments and introduces Seq1 as an example for the usage of the new classification system.


The ecology civilization requires us to reconsider the human and the natural relations,reconstructs the human and the natu- ral harmony.From the person and the natural historical condition,the realistic contradiction as well as the present age puzzled and so on aspects analyze,pointed out that the construction ecology civilization is to historical and the reality resonsideration result,also real- izes the human sustainable development way that must be taken,and proposed that the construction ecology civilization first requests the humanity to change the traditional concept,sets up the person and the nature harmonious natural view,the values and the develop- ment concept.


We consider a classical model in the kinetic theory of plasma—the Vlasov–Maxwell–Landau system. Global in time classical solutions near Maxwellians are constructed for hard potential and soft potential, i.e., γ⩾−1. The construction of global solution is based on an energy method. Meanwhile, global classical solutions of the Vlasov–Poisson–Landau system near Maxwellians for γ⩾−1 and the exponential decay of such solutions are obtained.


The Photovoltaic-based microgrid (PV-MG) has become the core of the integration application of the photovoltaic power system, and it's the most effective ways to make use of the solar energy locally. Currently, the feed-in-tariff (FIT) policy of PV-MG in China is fixed and far below the market price, which cannot fully display and contribute to the regulation tools' impact on the business investment of PV-MG. This paper makes research on the effective FIT policy's effect on the PV-MG investment. Firstly, this paper sets up PV-MG business model and analyzes the income distribution among participants. Then, this paper puts forward three kinds of FIT model, that are the fixed FIT(FFIT), constant premium FIT(CPFIT) and variable premium FIT(VPFIT) model. And the market price that main grid of the electricity imported from gird is divided into fixed price and TOU price. Based on this classification, this paper develops the optical charge and discharge strategies of battery storage system and the PV-MG overall operational strategies under multi-scenarios. Through MATLAB simulation, this paper can get the power flow and income distribution among relevant participants in PV-MG, and makes sensitivity analysis on relevant parameters. This model is applied to one of Shenzhen's actual microgrid model and verifies its effectiveness.


The port features decides its important strategic position in the Integrated logistics system, The quick increase and permanent development in Shenzhen seaport have made it a break - through and the core of development of Shenzhen logistics industry, therefore, developing port logistics industry with great effort is an important behaviour to practise logistics development strategy in shenzhen.


This study characterized the mean and fluctuating parts of the radial component of the local velocity in the stagnation region of an impinging, free-surface liquid jet striking a smooth flat plate. Four different nozzle exit conditions were studied, including fully developed pipe flow, a contoured nozzle, and turbulence-damped and undamped sharp-edged orifices. Liquid jet Reynolds numbers in the range 30,000 to 55,000 were investigated. Velocities were measured using laser-Doppler velocimetry. Mean velocities were found to vary nearly linearly with radial location, with the slope of the line being a function of distance from the impingement plate. Dimensionless mean velocity gradients, of relevance to the heat transfer, were found to be a strong function of nozzle type, but roughly independent of jet Reynolds number for a given nozzle type. Turbulence levels were also found to be strongly influenced by the nozzle exit-condition. Local heat transfer data corresponding to the flow structure measurements presented here are reported in Part 2 of this study. 22 refs., 9 figs.


Complex vibration signals of wind turbine gearbox were studied so as to extract the fault features.The measured vibration signals were filtered and reconstructed by Gabor transformation,and then the meshing frequency and its harmonic components were inhibited,after which bispectral analysis was carried out to the reconstructed signals that mainly include sideband components,random components and inherent frequency components.Finally,the difference of non-Gaussian feature between normal gear vibration signals and pitting gear vibration signals was revealed,and subsequently the characteristic values of non-Gaussian intensity were extracted.Results show that gear faults may change the distribution of nonGaussian components in vibration signals.The characteristic values of non-Gaussian intensity extracted from filtered signals are closely related to the gear pitting faults.The method is very simple in calculation,which therefore may be used in actual engineering projects.


Background/Aims The majority of data on the medical costs of caring for cancer is based on aged Medicare beneficiaries treated in the indemnity/fee-for-service (FFS) system. Much fewer data are available on the costs of treating cancer in patients less than 65 years old. Using data from 4 CRN sites, we examined the cost of treating cancer by phase of care and stage of cancer for aged (65+) versus adult non-aged (greater than 18 and less than 65 years) HMO patients. Methods We used a longitudinal case-control design to estimate cancer care costs for patients starting 12 months prior to diagnosis. Aged (N = 46,032) and non-aged (N = 46,423) HMO cancer patients were enrolled between 01/2000 and 12/2008. We sampled 171,448 aged and 203,312 non-aged controls from among all HMO members who had no tumor registry evidence of cancer prior to 2009. HMO controls were frequency matched to cancer cases on a 5-to-1 ratio by age group and gender. Health care utilization data were extracted for 2000–2008. Cost coefficients derived from modified national Medicare reimbursement systems were applied to utilization data and summed to total monthly costs per patient in 2008 dollars. Monthly costs were analyzed by four 12-month periods—Pre-diagnosis, Treatment, Survivorship, and End-of-life (EOL)—by case/control, aged/non-aged and stage I–III/IV. Only one year of Survivorship was included in this analysis. Results Average monthly cost differences between aged and non-aged were reported. Pre-Diagnosis: Aged > Non-aged (difference of $261, P <0.0001); both groups see sharp increases in quarter prior to diagnosis. Treatment: Non-aged > Aged costs ($201, P <0.0001). Survivorship: Aged > Non-aged ($44, P <0.0375). EOL: Non-aged > Aged costs ($2,173, P <0.0001). All groups experienced accelerating EOL costs. Late-stage cancer costs were greater than costs of early-stage and, except for the Pre-diagnosis phase, non-aged late-stage costs were higher than aged late-stage. Late-stage cancer costs were more variable in the Survivorship phase. Aged and non-aged cases were significantly more expensive than their controls in all phases. Conclusions Non-aged cases are more costly than aged cases during Treatment and EOL phases; however, pattern changes and age effects dominate during the Pre-diagnosis and Survivorship phases.


Reply from the Authors: As Dr. Lombroso points out, the effectiveness of carbamazepine and phenytoin for the treatment of paroxysmal kinesigenic choreoathetosis (PKC) has long been known: however it has not been widely realized that very low doses and levels were effective in completely abolishing the attacks. These doses and levels are lower than those usually required for the treatment …


PurposeThis study aims to examine Taiwanese male and female police officers' perceived stress during the COVID-19 pandemic.Design/methodology/approachData were analyzed based on surveys conducted with 1,671 officers in various cities and counties between May and July of 2021, during the period of level 3 alert of COVID-19 pandemic in Taiwan.FindingsIt was found that officers who perceived poor inter-agency coordination and higher risk of infection, and those who were assigned to home quarantine duty and stationed in the metropolitan areas of Taipei, which suffered the worst spread of infected cases, were more likely to exhibit a higher level of stress. On the other hand, police identity, COVID-19 self-legitimacy, supervisor support, COVID-19 information and adaptive emotion regulation were found to be associated with an enhanced level of mental health.Research limitations/implicationsThe surveys were conducted at the beginning of the community outbreak. Given the cross sectional nature of the data, the findings may not reflect officers' mental health at different phases of the pandemic.Originality/valueSuch study can add a cross-national perspective that can be utilized to generalize about policy perspectives related to police mental health at times of health crises, such as COVID-19 pandemic.


Election administrative violations occur at the time of the implementation of the general election by election organizers and contestants. Sometimes, they do not realize that they have committed a violation. Since the general election during the reformation period after the fall of the New Order in Indonesia, there have been frequent violations of election administration resolved through administrative courts through the State Administrative Court. The dispute resolution was carried out after complaints were made through Bawaslu and DKPP as administrative dispute resolution (ADR) institutions and did not bring results.  This administrative violation is considered detrimental to the candidate contesting the election, causing a dispute between the candidate contesting the election and the organizers of the general election. This article examines the process of resolving electoral administrative disputes in Indonesia and the judiciary's role in resolving electoral administrative disputes. Several examples of cases of election administration violations that occurred and their causes obtained through empirical studies using the technique of documenting judges' decisions that have permanent legal force at the Supreme Court of the Republic of Indonesia were analyzed using inductive logic.


Collectively, despite disruption and stress related to the COVID-19 pandemic, we continue to make progress on our goals The IEEE Computer Society (CS) members and contributors have discovered new ways to learn and teach, conduct research and publish, attend and facilitate virtual conferences, look for and implement computing-based solutions to health-care and logistics emergencies, and most impressive of all, support and connect with one another in this time of shifting priorities and increasing physical isolation Thanks to our members' resilience and resourcefulness, the CS has continued to make meaningful contributions and create new opportunities


The photonic-crystal surface-emitting laser is a new-generation semiconductor laser capable of emitting a high-power, high-quality (i.e., high-brightness) beam, as well as on-chip two-dimensional beam steering, lasing in various wavelength regimes, and on-chip ultra-short self-pulsation, owing to their freedom of light-matter control. Here we introduce light detection as a new functionality, wherein the photonic-crystal laser is operated under reverse-bias conditions. We find that the photonic-crystal laser operated under reverse-bias conditions has a very high shunt resistance and a low dark current, which are essential qualities to achieve high detectivity. In addition, high responsivity is achieved by utilizing proper band-edge-modes and $Q$ -matching conditions for resonant light absorption. Furthermore, by employing photonic-crystal lasers as the detector as well as the laser source, a direct time-of-flight distance measurement is successfully demonstrated.


The knowledge of the interrelationships among the photometrical, electrical and thermal (photoelectrothermal) parameters is extremely important to design lighting systems based on light-emitting diodes (LEDs). This paper proposes a novel methodology based on the luminous flux estimation of LEDs considering a photoelectrothermal design space. The main contribution of the proposed methodology is the use of only LED datasheet information, which avoids experimental tests to obtain the LED data. This methodology provides 3D and 2D space designs, which helps to identify the luminous efficacy, heatsink thermal resistance and junction temperature of the system without requiring experimental tests or simulations with high computational cost. Thus, the designer can define the minimum system requirements and design the system with emphasis in the desired features. The proposed design methodology has been verified experimentally using three different scenarios, presenting satisfactory results.


The architecture of Friends meetinghouses on the East Coast is generally of one type. Although many of these are charming and architecturally interesting and effective works, they usually present subdued, utilitarian variations of early Georgian style, most often by a local architect or builder. Most new structures follow the old patterns, and in the few cases where architects of some stature have been involved, either from weight of tradition or a feeling that the proper form had been found, significant departures have been almost nonexistent. The small meetinghouse of Newton Monthly Meeting in downtown Camden, New Jersey, although well within the expected limits of muted expression and simplicity, presents a unique and pleasing variation of the pattern. Starting from an indigenous early eighteenth-century "clapboard Quaker" cabin, it was enlarged and remodeled in 1885 in the oft-riotous, but here subdued, Queen Anne style by Wilson Eyre, Jr., an important creative architect of the period. The meeting traces its origins back to 1679, the time of the founding of Camden by William Cooper, an English convinced Quaker. With Friends from across the Delaware River at Shackamaxon (Kensington, Philadelphia) a meeting was formed under the care of Burlington, New Jersey, Meeting. The first meetinghouses were near Newton Creek in what is now Gloucester; in 1801 a brick house was erected at Mt. Vernon and Mt. Ephraim Avenues, the first house of worship within the present limits of


The process of locating components in an available space while satisfying spatial relationships among the components is called packaging. The task requires extensive spatial reasoning about geometric shapes. It is a generic design task common to many domains. It is also very time-consuming, especially as machines become more compact and complex. This paper describes progress toward automation of the packaging problem. An approach is proposed to determine the optimal locations of components in an assembly from spatial relationships between the components. The approach utilizes a novel combination of optimization and solid modeling techniques.


Since the mid-1980s, terms such as "the everyday" (Alltag), "expe rience", "life-world" and "culture" have achieved a meaning and significance which have come to define the new direction taken by social history in the last decade.1 In what follows, I will first of all outline the conjunctural links between these new or renewed concepts and the criticisms that have been directed at objectivist structural functionalism in historical social science. I will then go on to ask w hether labels such as "the history of everyday life" (Alltagsgeschichte), the "history of experience" (Erfahrungsgeschichte) or "his torical anthropology" (Historische Anthropologie) are able to symbolise and develop fu rther post-structural changes in social history. O r might it no t be m ore appropriate to speak about the beginnings of a new historical cultural science (Historische Kulturwissenschaft)} Are we dealing with the belated in troduction of a qualitative paradigm2 in the field of historical social sci ence (Historische Sozialwissenschaft)'} Do the exponents of the new approaches already constitute a "third generation" of historical social scientists, succes sors to both the first generation, who form ulated their conception of an historical social science in the 1960s and 1970s and defended it against the m ainstream of the time,3 and the second generation, who spread its new social scientific paradigm in the 1980s? Finally, I will ask where all this fits into the discourse of post-modernism.


Background: The proportion of pharmaceutical expenditure out of total health-care expenditure in South Korea is high. In 2016, 25.7% of national health insurance (NHI) spending was for pharmaceuticals. Given the increasing demands for the access to newly introduced medicines and following increase in pharmaceutical spending, the management of NHI pharmaceutical expenditure is becoming more difficult.
Methods: This study analyzed the data claimed to NHI for pharmaceutical reimbursement from 2010 to 2016.
 Results: The policy implications with respect to the trends and problems in spending by drug groups were elicited. First, the proportion of off-patent drugs spending which were treated to chronic disease was much higher than anti-cancer drug spending. Second, the spending to the newly introduced high-costed medicine increased, however, current price-reduction mechanism was not sufficient to manage their expenditure efficiently.
Conclusion: Our system seems to need several revisions to improve the efficiency of pharmaceutical expenditure and to cope with high-costed medicines. This study suggested that the prices of off-patent drugs need to be regularly readjusted and the Price-Volume Agreement System should be operated more flexibly as well.


Objective
The aim of this study was to explore the effect of low density lipoprotein(LDL) on the proliferation and differentiation of MC3T3-E1 osteoblasts, as well as the expression of low density lipoprotein receptor-related protein 5(LRP5) and dickkopf-1(DKK1) mRNA of MC3T3-E1 osteoblasts. The possible mechanisms of the treatment of atorvastatin on LDL expression in MC3T3-E1 osteoblasts were also investigated.

Methods
Proliferation, osteocalcin expression, LRP5, and expression of DKK1 mRNA of MC3T3-E1 with interaction of LDL at 0.05, 0.10, 0.20 mg/ml levels after 24 h, 48 h, 72 h were detected by CCK8, ELISA, and fluorescence quantitative PCR. Furthermore, proliferation, osteocalcin expression, LRP5 and DKK1 mRNA of MC3T3-E1 after the treatment of atorvastatin of 10-6mol/L and 10-5mol/L were also be studied, respectively.

Results
The effect of LDL on proliferation, expression of osteocalcin and expression of LRP5 and DKK1 mRNA in MC3T3-E1 osteoblasts was the most obvious under LDL with 0.20 mg/ml level. Under that level, atorvastatin(10-6 mol/L or 10-5 mol/L) was able to make the proliferation of MC3T3-E1 osteoblasts in 48 h and 72 h be decreased, while significantly caused upregulation of osteocalcin, LRP5 mRNA expression; and down regulated DKK1 mRNA expression(all P<0.05).

Conclusions
Atorvastatin can reduce the inhibitory effect of LDL on the proliferation and differentiation of osteoblasts. The mechanisms of atorvastatin on osteoblasts are possibly related to the osteoblast proliferation and expression of LRP5 mRNA and DKK1 mRNA of osteoblasts of wnt signal pathway. (Chin J Endocrinol Metab, 2015, 31: 707-711)

Key words:
Low density lipoprotein; Atorvastatin; Osteoblast; Low density lipoprotein receptor-related protein 5; Dickkopf-1


Organic-inorganic hybrid materials composed of phenolic resin and silica were prepared by in-situ polymerization of silicon alkoxides in phenolic resin matrix. The hybrid materials showed uniform m...


The lecture presents a recent methodology allowing one to execute numerical computations with finite, infinite, and infinitesimal numbers on a new type of a computer – the Infinity Computer – patented in EU, USA, and Russia (see [20]). The new approach is based on the principle 'The whole is greater than the part' (Euclid's Common Notion 5) that is applied to all numbers (finite, infinite, and infinitesimal) and to all sets and processes (finite and infinite). It is shown that it becomes possible to write down finite, infinite, and infinitesimal numbers by a finite number of symbols as particular cases of a unique framework different from that of the non-standard analysis. The new methodology evolves ideas of Cantor and Levi-Civita in a more applied way and, among other things, introduces new infinite integers that possess both cardinal and ordinal properties as usual finite numbers (its relations with traditional approaches are discussed in [8–11,14,19,21,27]). It is emphasized that the philosophical triad – researcher, object of investigation, and tools used to observe the object – existing in such natural sciences as Physics and Chemistry, exists in Mathematics, too. In natural sciences, the instrument used to observe the object influences the results of observations. The same happens in Mathematics where numeral systems used to express numbers are among the instruments of observations used by mathematicians. The usage of powerful numeral systems gives the possibility to obtain more precise results in Mathematics, in the same way as the usage of a good microscope gives the possibility to obtain more precise results in Physics. A numeral system using a new numeral called grossone is described (see [15, 16, 18, 22]). It allows one to express easily infinities and infinitesimals offering rich capabilities for describing mathematical objects, mathematical modeling, and practical computations. The concept of the accuracy of numeral systems is introduced. The accuracy of the new numeral system is compared with traditional numeral systems used to work with infinity. In order to see the place of the new approach in the historical panorama of ideas dealing with infinite and infinitesimal, see [8–11, 14, 19, 21, 27]. In particular, connections of the new approach with bijections is studied in [11] and metamathematical investigations on the theory can be found in [10]. The new methodology has been successfully used in a number of applications: for study-


According to the requirements of the country to speed up the construction of modern vocational education system, a group of ordinary undergraduate institutions of higher learning are transformed into applied technology-based higher education institutions. The key to transformation is teaching reform, and the design of classroom teaching mode is an important part. This paper studies and explores the design of teaching mode under the background of applied curriculum reform in private undergraduate colleges. It analyzes the traditional classroom teaching mode and the current popular multi-application teaching methods, and proposes a new concept based on the teaching task. Self-organizing classroom teaching model. It has a universal significance for the design of classroom teaching mode in private undergraduate colleges.


Ultra intense laser (UIL) light can create relativistic plasmas whose electron oscillation energy exceeds the electron rest mass. The interaction of such relativistic plasma with UIL exhibits distinct relativistic effects such as relativistic self-focusing or relativistic transparency as well as very rich nonlinear effects such as relativistic fi lament instability or stimulated Raman scattering. In addition to the brief review of these phenomena, we describe the channel creation and the anomalous penetration by UIL (super-penetration) as an application of relativistic plasma.


A model to describe molecular fragmentation into several fragments is presented. The case where dissociation is induced by the absorption of a single or several photons from ultrashort pulses is considered. Time-dependent perturbation theory is employed to describe the excitation process and the subsequent fragmentation dynamics is treated using various theories treating direct and indirect break-up processes. The multiple fragmentation of the Fe(CO)5 molecule serves as a numerical example. Different experiments are simulated and, regarding the simplicity of the model, an overall excellent agreement between theory and experiment is found, thus providing an insight into the excitation and fragmentation dynamics under various conditions.


This book, the sixth in a series entitled Progress in Respiration Research (the first was published in 1962), comprises papers presented at the 1969 meeting of the European Society for Pathophysiology of Respiration. All papers pertain to chronic bronchitis. Of the 71 contributions, 36 are in German, 20 in English, and 15 in French; consequently, the book will have limited value for physicians who read only English. The dust jacket's statements that the contributions indicate how "research work is having a significant effect on the daily practice of medicine" and that the volume gives an excellent summary of therapy of bronchitis are unwarranted. There are only a few papers on treatment, and one of these concludes that "judgment of results of therapy of chronic nonspecific obstructive lung diseases is a very complicated problem." Although the volume is not one of those logorrheic products of symposia and although the papers are


E2" obtained from Lemmon's E2 (XXIII 346) by adding O(p-*-p) and since T ± E2" (E2 = S2). The proof of this last is carried out by a matrix which shows that D(/> -*•/>) is not a thesis of E2. (It is of course a thesis of T.) E2 is similarly shown to be the union of an infinite series of systems and likewise each E2 and ET (=• {E2 + Q(p -*p) -*• D D O -*•/>)}) and so none of them are finitely axiomatizable either. Lemmon also notes (p. 308, n. 9) that Aqvist's proof of 2 above assumes that Becker's rule holds in all extensions of S2. Whether to call this a fault in Aqvist's proof is perhaps a terminological matter resulting from the ambiguity of the name 'S2' but it does leave open the question whether every system between S2 and T (except of course T itself) is unreasonable in Hallddn's sense. (It should be noted that for Lemmon a system is essentially a collection of theses together with the rules of substitution and detachment. I.e., all extensions are assumed to be closed under these rules but not necessarily any others.) That any system between S2 and T is Hallcten-unreasonable is a by-product of Lemmon's 1966 article. Lemmon calls a system S strongly H-incomplete iff there are wff's A and B each containing one propositional variable and such that the variable in A is different from the variable in B and that hs A v B but neither l-8 A nor ra B. This is the original definition of XVI 273. He calls S simply H-incomplete if the same holds but with the condition relaxed that A and B contain only one variable (this is McKinsey's definition of XIX 67). Theorem 1 states that a system S is incomplete iff there are disjoint systems Sx and S2 such that the theorems of S are precisely those formulas which are theorems both of Si and S2 . He then proves that where L is the system obtained by adding to PC the rule REhA*-*B => hDA<-» DB, and where T is p-*p and F is — (p-*p) then hL0 F v • "T. A number n is said to be a necessity gap for a system S iff had "A for no wff A. Theorem 2 (p. 298) states that any system S containing L and contained in PC (i.e., T + A -> QA) which has necessity gaps is strongly H-incomplete. In particular, any system between E2 and T satisfies this condition thus establishing Aqvist's result 2 even for extensions of S2 which like Lemmon's E2 (vide supra) do not satisfy Becker's rule. Theorem 3 (p. 299) establishes that if S has a maximal characteristic matrix (i.e., where the matrix is regarded as a Boolean algebra and the set of designated elements is a maximal filter) then S is H-complete. The problem of finding general methods for establishing that systems have maximal characteristic matrices is still very much open, and Lemmon conjectures that the converse of Theorem 3 is false.


Two interlayers, blended interlayer based on TPD-oxetane with PFO-TPD-OCH3 and crosslinkable polymer interlayer based on Poly(RO2-spiro-TPA-oxetane), were introduced in polymer light-emitting diodes (PLEDs). Both interlayers showed resistance to organic solvents and the performance of PLEDs was greatly enhanced when each interlayer was inserted. The maximum luminescence efficiency of 0.147 cd/A at 11 V and the maximum luminescence of 739 cd/m2 at 15 V have been achieved with blue light emitting polymer, Poly(RO2-spirobifluorene).


Along with the development of economy,politics,culture of China's ancient society,the mode of China's early stage political thinking completed the change from attached importance to God to attached importance to people in the Warring States.This change not only realized the political thinking breakthrough of human from perception to reason,but also aroused the thought rising of people-being-foundation,and impelled the China's early stage political thinking to take the development road of humanism.


The focus of the present paper lies on the identification of mechanical two-inertia-systems based on frequency response measurement without the need of angular transducers. The calculation of the frequency response is carried out by excitation of the system with Pseudo-Random-Binary-Signals followed by a signal processing procedure utilizing the Welch-Method. Former research has pointed out that this approach leads to reliable, good results with measured signals of the systems current and speed. As actual research tends to the control of variable speed drives without encoders, the paper gives an approach for an identification method using estimated speed values from an observer structure.


Background The predictor of radiographic spinal progression is the presence of syndesmophytes at baseline in axial spondyloarthritis (axSpA) and fat metaplasia on spine maybe predict the formation of new syndemophytes. Some studies suggests that fat metaplasia maybe a potential starting point for new bone formation and have a general systemic effect on new bone formation in spine, rather than results from local inflammation. Recent studies suggest that fat metaplasia on sacroiliac joint (SIJ) MRI at baseline is associated with spinal radiographic progression in axSpA patients. Objectives So in this study, we investigated for propensity to fat metaplasia on SIJ in axSpA patients. Methods The 357 patients who fulfilled the ASAS axSpA criteria were enrolled. All underwent MRI on SIj with T2 MR image, T1 fat suppressed with enhanced and short τ inversion recovery (STIR) image at baseline and lumbar spine radiographs at baseline and after 2 years. Inflammatory and structural lesions on SIJ MRI was scored using the SPondylo Arthritis Research Consortium of Canada (SPARCC) method. spinal radiographs were scored using the Stoke AS Spinal Score (SASSS). Multivariate logistic regression analysis was performed to identify for propensity to fat metaplasia on SIJ in axSpA patients. Results Among the 357 patients on baseline SIJ MRI finding, 182 patients showed fat metaplasia on SIJ, 148 patients showed erosion and 27 patients showed ankylosis. Propensity to fat metaplasia in axSpA patients showed the male, HLA-B27 negative, smoking, back pain onset time within 6–12 months at time of diagnosis, uveitis, peripheral arthritis, compared to erosion and anylosis on SIJ in axSpA patients. The patient with fat metaplasia or ankylosis on SIJ at baseline showed increased SASSS but there was no significant change in SPARCC over 2 years. univariate logistic regression analysis showed back pain onset time within 6–12 months at time of diagnosis and uvitis as a significant predictors of fat metaplasia. multivariated logistic analysis showed back pain onset time within 6–12 months at time of diagnosis as an affecting factor for fat metaplasia on SIJ (OR,5.67; 95% CI 4.71–17.95).Abstract THU0270 – Table 1 The radiographic spinal progression over 2 years according to structural lesion in the sacroiliac joints observed on baseline MRIAbstract THU0270 – Table 2 Univariate and multivariate analysis of affecting factor for fat metaplasia on SIJ Conclusions The back pain onset time within 6–12 months at time of diagnosis was affecting factor for propensity to fat metaplasia on SIJ in axSpA patients statistically and fat metaplasia on SIJ was associated with radiographic spinal progression in axSpA patients. so the early detection of fat metaplasia on SIJ in axSpA patients was important to protection of radiographic spinal progression. References [1] Maksymowych, et al. MRI evidence of structural changes in thesacroiliac joints of patients with nonradiographicaxial spondyloarthritis even in the absence of MRI inflammation. Arthritis Research & Therapy2017;19:126. [2] Fat Metaplasia on Sacroiliac Joint Magnetic Resonance Imaging at Baseline Is Associated with Spinal Radiographic Progression in Patients with Axial Spondyloarthritis. Plos oneaugust 2015 13. Acknowledgements none Disclosure of Interest None declared


The aim is to explore the possibilities of improving motor and sensitive disorders to ensure the highest possible social adaptation - the expansion of self-service skills, opportunities for affordable employment, or the restoration of professional activity flax. Methods: To study the possibilities of improving the social reintegration of patients during rehabilitation in a mud resort, we observed 240 patients who had an injury to the cervical spine 24 years. Disease duration ranged before 3 years, 4-7 years, more 7 years. We studied the occupational therapy method and group psychotherapy method. All patients were divided into three representative groups: 91 patients (group 1) received a course of balneoplasty therapy in the form of mud applications on the spine and lower limbs at a temperature 42-44 0C, exposure time 20 min, placement of procedures - every other day, for a total of 12-15 procedures per treatment; on days free of mud cure, hydrokinesitherapy was performed in a pool with warm (29-32 0С) brine water, 12-15 procedures, and also apparatus physiotherapy procedures, massage and exercise therapy. In addition to the course of balneopedotherapy, 149 patients also received ergo-therapy and psychotherapy (90 people - group 2) and only occupational therapy - 59 people (group 3). Results: Improvement of post-traumatic organic neurological disorders caused by balneo-mud therapy creates a favorable basis for conducting training activities that expand patients' functionality. The inclusion of ergotherapy in the rehabilitation process of spinal patients in a balneo-mud resort is appropriate and justified. It allows not only to expand the functionality of patients but also to reduce the time to master the essential self-care skills and consolidate them. Conclusion: The inclusion of psychotherapy in the complex of occupational therapy is desirable. It allows you to influence the psycho-emotional state of the patient and improve the effectiveness of training activities, especially in male patients. Changing the hospital and closed home atmosphere to the conditions of the resort, the possibility of broad communication, participation in various social events significantly change the psycho-emotional state of patients, increasing their activity, causing an increase in the setting for inclusion inactive life..

Keywords: ergotherapy, psychotherapy, spinal injuries, activity and participation, rehabilitation, social adaptation,


Criticism of the Pardoner's Prologue and Tale has long held that Roman de la Rose's Faux Semblant lay behind Chaucer's portrait of a hypocritical churchman. Yet however much Faux Semblant's speech may explain the Pardoner's blatant hypocrisy, the rhetoric and content of his confession and his later intemperate "salesmanship" to the other pilgrims and to Harry Bailly in particular can be derived largely from the commercial discourse of medieval France, specifically the practices of provincial itinerant salesmen revealed in the comic and satiric Old French "trade" poems: Rutebeuf's "Dit de l' Herberie" and the anonymous "Dit du Mercier," which share a surprising number of details with Chaucer's poem and probably served as models for his tavern realism, his faux relics made with "latoun," and his treatment of the Pardoner as emasculated. Moreover, like Chaucer's poem, the two "Dits" are heavily ironic in revealing their narrators' deceptive and unsavory natures, either through direct confession or through au...


the Obręczówka and the Przepaść river valleys located in the north fragment of the Sandomierz Upland (Kondracki 2001) belong to those areas where numerous archeological excavations have been carried out for a long time (Podkowińska 1961; żaki 1972; bąbel 1975; Kowalski 1975; Uzarowiczowa 1975; Uzarowicz -Chmielewska 1979; bąbel 1998; balcer 2002; Orzechowski 2007; Jedynak, Kaptur 2008; Kaptur 2010; Przeździecki et al. 2011; Orzechowski 2013; Kaptur 2014) (Fig. 1). the settlement development within the border between the Sandomierz Upland and the iłża Foreland, lasting, with breaks, from the Paleolithic period, resulted in the cultural diversification of archeological sites. Within the above-mentioned river catchment areas, settlement development was connected mainly with easy access to water, fertile soils derived from loess (in the case of the Przepaść river – chernozems), geology of the region (flint outcrops) and configuration of the land (defensive function of sites). Department of General Geology and Geotourism, Faculty of Geology, Geophysics and environment Protection, aGh University of Science and technology 30-059 Kraków, al. Mickiewicza 30, Poland; email@example.com


Games live streaming is growing rapidly as a form of entertainment. A game streamer will like to know what game to stream in order to attract huge number of viewers and followers which in turn will generate sizable income for the streamer. Using streamer's metrics, the main goal of this research work is to design and develop a set of resources that a streamer can use to maximize the number of viewers and followers for a particular game and when to play the game. This research develops two models using machine learning techniques that can be used by game streamers to maximum the returns on investment. When both model predictions are presented as percentage, Model 1 using regression algorithms provides a MAE of 5.48 meaning the prediction has an error within 5.48% of the streamer's total follower count. Also, Model 1 has 85.46% of its predictions' absolute error less than or equal to 5. Similarly Model 2 with 2.53 MAE and 87.68% of its predictions' absolute error less than or equal to 5.


Based on acknowledgement of the theory of causality and necessity,a scientific model is advanced in this paper to achieve analytic knowledge of human cognition.Based on this model of cognition,the essence and or igin of the two categories of uncertainty-randomness and fuzziness-are analyze d and elaborated.Furthermore,a few case studies are performed,focusing on the d evelopment of human knowledge.The author concludes that the objective world esse ntially does not characterize uncertainty in any sort;uncertainty is a subjectiv e character of human cognition and it stems from the limitation of cognitive abi lity.The significance of the scientific methods that dealing with uncertainty,su ch as stochastic mathematics and fuzzy mathematics,is to provide us with a cogni tive means so as to help us to understand the real world effectively with our li mited cognitive ability,rather that to depict the nature of the objective world.


Understanding geological and hydrogeological characteristics in coastal areas is an issue of paramount importance considering its socio-economic relevance, whereas, to date, limited information has been acquired due to the lack of suitable survey methods. We have conducted an airborne electromagnetic survey in an alluvial coastal plain, Kujukuri, in southeast Japan, to examine the effectiveness of elucidating the subsurface electric-resistivity structure both on land and offshore. Our approach was to use a grounded electrical dipole source and a helicopter-towed magnetic field receiver. Repeated surveys both at high and low tides revealed that a reliable resistivity structure is available to a depth of 300–350 m in coastal areas where shallow (∼5 m deep) water prevails.


Polyethylene glycol (PEG)-laser nephelometer assay for the detection of circulating immune complexes (i.c.) has been developed. The method proved to be useful in the detection of i.c. in sera of rabbits with chronic serum sickness. I.c. were detected in 28 animal experimental sera and in samples with preformed immune complexes, but not in sera of 10 healthy rabbits and 5 rabbits prior to immunization. Laser nephelometer assay is a rapid, simple, quantitative screening test suited for clinical use as a first step in i.c. detection.


The seasonal distribution of the talitrid amphipod Trinorchestia trinitatis on an exposed sandy beach was examined in relation to moisture content and temperature profiles of the sand. Sand in which animals burrowed always had moisture levels >1.7% of the wet sediment weight throughout the year. Monthly mean moisture values for talitrids ranged from 3.0-5.0%. During winter, talitrids were found high up on the beach far from the reach of the surf and burrowed deeply to avoid freezing. After the thaw in early spring, animals reduced their burrow depth and moved downshore. Large animals began migration earlier than smaller animals. From late spring to summer, the population concentrated near the strandline left by wave action during the preceding high tide, burrowing shallowly. During this period the distribution patterns varied with animal size and reproductive condition. Small animals, especially juveniles, were located shoreward of and burrowed at shallower depths than large animals and ovigerous females, which were located higher on the beach. In late summer, burrowing depth of talitrids increased as temperatures in the surface layers rose. Behavioral responses, such as burrowing and surface migration to cope with the wide fluctuation of environmental factors, mainly sand moisture content and sand temperature, are suggested to be important mechanisms enabling T trinitatis to survive in the physically severe sandy beach environment.


Celite coated with potassium fluoride was found to be an effective and economical reagent for hydrogen-bond-assisted reactions. C-, N-, O-, and S-alkylations were conveniently performed in high yields under mild conditions.


This study will not only provide the needed information on the use of Terminalia suparba to increase ovulation in the female Clarias species which is the basis for further work on the reproductive biology of this fish, it will equally establish which hormone in the plant is responsible for inducing ovrulation Clarias gariepinus. ABSTRACT Thisstudyfocused on the assessment of Terminaliusuparba (bark, leave and root) based diet to improve theovulationof Clarias gariepinus broodstocks. Tenfemale and ten male broodstocks were obtainedfrom areputablefish/arm in Ogun State. Nigeria and werefed with the dietsfor jour weeks before the breeding exercise. The latency period observed in treatments 1 to 4 was 4hoUTS 30minules while tile ovulation period in treatment 5 was Bhours. There was no significant different (P>O.05) among the means. The broodstocksin Treatment 2 (Rout) has the highest fecundity count (2001) while those in Treatment 5 (control)has the leastfecundity count (l490). The phytochemical analysts of the plant materials showed thepresence of Alkaloids, Tannin, Phenol, Glycoside, Flavonoids, Steroids, Phlobatannin, Saponin. Anthraquinones. Thephysical and chemical parameters of water observed showed that dissolved oxygen valuerangesfrom 3.28 -4.60, pH 6.5 - 8.5, temperature 28.0 - 2R.R and conductivity 8.9 - 9.20. It is thereforeconcluded that the inclusion of'Terminalia suparba in thefeed of Clarias gariepinus broodstock will notonly improve ovulation butalso reduce the latencyperiod.


In the past few years, many Information Technology (IT) departments have been vastly expanded or created, and new processes have come into existence. With these increasing numbers of elements, organizations face the challenge of process integration. They must seek to integrate what are often rapidly changing sets of procedures to make processes work synergistically and maximize the return from IT. Current process frameworks and guidelines such as Capability Maturity Model Integration (CMMI) or Project Management Body of Knowledge (PMBOK) fall short of the challenges posed by process integration in Information Technology. This paper provides the basis of a framework for IT process integration. To do this, two groups of integration strategies are considered. First, we discuss horizontal and vertical integration strategies as a single group. We then address a second group of initiatives consisting of foundation building, innovation, and automation as complementary strategies to the first. Finally we discuss future trends in process integration.


The loss of talented students from Science, Technology, Engineering and Math (STEM) fields is a major challenge for U.S. technological advancement and global competitiveness in the 21st century. Although inclusive teaching strategies can help student retention, formal instruction in pedagogy is often completely absent from postdoctoral training. Thus, increased access to training in pedagogy for student teaching assistants (TAs) and postdoctoral scholars has the potential to improve the quality of instruction in the STEM classroom. In order to provide TAs with the tools they need to create a safe learning environment that respects student diversity and encourages learning, a group of postdoctoral scholars in the Division of Biological Sciences at UCSD have developed a TA training workshop on inclusive teaching. The workshop is based on the learning goals of (1) raising TA awareness of the impact of identity and classroom climate on student learning, (2) helping TAs recognize the importance of inclusivity in effective teaching, and (3) empowering TAs with a pedagogical toolkit for creating an inclusive classroom. The workshop uses a combination of self‐reflective and group activities to personalize diversity issues and model best practices for inclusive teaching. Based on participant pre‐ and post‐surveys, this workshop has been successful in promoting awareness of unconscious bias and providing strategies that participants can use in their classrooms to facilitate and encourage student learning. This workshop will continue to provide an opportunity for postdocs and undergraduate and graduate teaching assistants to increase their awareness and understanding of the importance of diversity and inclusiveness in learning.


Wisdom: The advice ofthe old is never overlooked. A wise person learns through other people smistakes. Two waterfalls do not hear each other (said about two people loudly arguing with each other). Of particular interest to missiologists and missionaries in the field are the Gikuyu proverbs on Moving OutlMission Spirit: Staying in one place begets lice. Traveling is learning. Traveling opens one's eyes. Traveling is seeing. A person who does not travel says that only his mother knows how to cook well. There are certain Gikuyu proverbs that are found in other world languages and reflect universal values: Charity begins at home. A long journey/trip begins with one step. The bird that wakes up early eats the best worm. Prevention is better than cure. A little knowledge is a dangerous thing. This major contribution to African proverbs scholarship challenges other scholars to make similar collections in other major African languages. These ongoing contributions to African oral literature and contextualization are echoed in the Gikuyu proverb: A river is enlarged by its tributaries. It is hoped that the next printing will correct the misspellings and typographical errors in this 2001 edition. An extensive bibliography including booklets and articles on Gikuyu proverbs would be useful.


Halogen-free flame-retardant, expandable styrene polymer granules containing a) 5 to 50 wt .-% of a filler selected from pulverulent inorganic substances such as talc, chalk, kaolin, aluminum hydroxide, aluminum nitrite, aluminum silicate, barium sulfate, calcium carbonate, titanium dioxide, calcium sulfate, silica, quartz flour, aerosil, alumina or wollastonite, and b) 2 to 40 wt .-% of expandable graphite having a mean particle size in the range of 10 to 1000 microns, containing c) 0 to 20 wt .-% of red phosphorus or an organic or inorganic phosphate, phosphite or phosphonate, d) 0 to 10 wt .-% carbon black or graphite, and to processes for their preparation and use for the preparation of self-extinguishing expanded polystyrene foams.


A number of copolymers on the basis of acrylate or methacrylate copolymers containing nitrogen and of ethylene copolymers containing structural units of N, N-diethyl-2-aminoethyl acrylate and 2,2,6,6-tetramethyl-4-piperidyl acrylate or of the vinyl ester of N, N-dimethyl-e-aminocaproic acid were synthetized. These copolymers were added to polypropylene before spinning. The dyeability of stretched fibres with acid dyestuffs was evaluated.

Eine Anzahl Copolymere auf Basis von stickstoffhaltigen Acrylat- und Methacrylatcopolymeren sowie von Ethylencopolymeren, die N, N-Diethyl-2-aminoethyl-acrylat- oder 2,2,6,6-Tetramethyl-4-piperidylacrylat-Struktureinheiten enthalten, und auf Basis des Vinylesters der N, N-Dimethyl-e-aminocapronsaure wurden synthetisiert. Diese Copolymere wurden dem Polypropylen vor dem Verspinnen zugesetzt. Die Anfarbbarkeit der gereckten Fasern mit sauren Farbstoffen wurde gepruft.


Based on the Minimum Gibbs Free Enthalpy algorithm (FEM) and a model of reaction zones located around electrode tips in the submerged arc furnace, an analysis of the raw material chemical composition influence on the ferrosilicon smelting process was carried out. A model of the ferrosilicon process in the submerged arc furnace is a system of two closed isothermal reactors: an upper one with a lower temperature T1, and a lower one with a higher temperature T2. Between the reactors and the environment as well as between the reactors inside the system, a periodical exchange of mass occurs at the moments when the equilibrium state is reached. Based on the model, sets of calculations were performed: for a Fe-Si-O-C system and, subsequently, for a more complex Fe-Si-O-C-Al-Ca-Mg-Ti system. For both systems, the energy and mass balance values were calculated and the effects of raw material contaminants on the efficiency of the ferrosilicon melting process were determined.


Aggression brings adverse effects on individuals and the environment, and often developsinto social problems. This meta-analysis study aimed to find out the correlation between self-control and aggression. The used samples based on 18 primary studies from 10 onlinejournals published in 2002 - 2017 which is found by searching on online database journal viawww.lib.ugm.ac.id. Two artifacts allowed for correction in these study are sampling errorand measurement error. The results of the analysis provided support for the hypothesis thatself-control had a negative correlation to aggression, therefore self-control inhibits the emerge of aggression behavior.


Introduction: Vitiligo is a protracted skin disorder in which areas of skin lose their color. Numerous research has revealed that psychosocial therapies can lessen the effect of social stigma on the degree of vitiligo impairment. Objective: This study examines how an educational intervention affects the knowledge and attitudes of Egyptian and Saudi professionals and non-professionals toward patients with vitiligo. Materials and Methods: A quantitative, comparative quasi-experimental study was conducted with 357 participants at the College of Nursing-Jeddah (CON-J), Saudi Arabia, and the Faculty of Nursing, Menoufia University, Egypt. To complete the study, three valid and reliable tools were utilized: demographic and personal characteristics, the IOF Scale, and knowledge and attitudes. Results: A high percentage of Egyptians (81.4%) and Saudis (81.1%) had a higher education level, and nearly two-thirds (66.5%) were single. The total sample (n = 375) spanned the ages of 20 to 50 years. Most (94.6%) Saudis live in cities, 82.2% are health professionals, and nearly two-thirds (69.7%) are middle-class. After the intervention, there was a high level of knowledge difference between Egyptian and Saudi participants (professional and non-professional) at (p = 0.021); (p = .001), respectively.


The study aims to design the information system of fiber optic core management based on Android at PT.Telkom Kebumen. This study used qualitative method with a descriptive approach. Data collection techniques are carried out by observation and literature study that related to research. The software development method used waterfall. The problem of the research result are data processing of core management still using Ms.Excel so that the data received by technicians is not accurate because the data changes and data additions are slowly, and to looking for data is too difficult because the data that saved  on Ms.Excel is too much. There are suggestions that submitted, designing a new information system that can help the job so that can be more effective and  efficient. By utilizing the advanced android technology which owned by  all technicians.


This study aims to determine behaviors of college students regarding use of credit card and their level of credit card literacy. For this end, a survey is conducted with 720 respondents studying in Gaziantep University. According to findings of the study, credit card literacy level of the students is determined as 43%. One of the findings is that credit card literacy level of students differs according to gender and the faculty that they are studying. Also it is observed that students who get a credit card after a conscious reading of credit card agreement and students who regularly pay the debt have a higher level of credit card literacy compared to other students.


In this article a study about catalyst regeneration is been put forward. A study of how catalyst regeneration is done, why there is a need of regeneration and also about catalyst deactivation mainly in refinery processes. Catalyst Regeneration is widely used in many industries by in-situ or ex-situ methods as an economical beneficial technique for processes. In this article I have also shared some important test done on catalyst before they are used in a specific process. Catalyst Regeneration is mainly seen where the spent catalyst is costly.


Biodiesel emerges as an alternative biofuel for fossil ones because it is less polluting and can be produced from renewable sources. However, biofuels are generally more susceptible to auto-oxidation than fossil ones. Some fundamental characteristics in biofuel must be controlled in order to permit the correct operation of engines, so that the National Agency for Petroleum, Natural Gas and Biofuels (ANP) establishes specific resolutions about that. In most cases, the biofuel is poorly resistant to auto-oxidation, being required the addition of extrinsic antioxidant agents. In this work, it was demonstrated the curcumin is a natural product with excellent antioxidant behavior to be added to commercial biodiesel samples. The physical-chemical characteristics, induction period measured using Rancimat method EN14112 and acid number by ASTM D 664 method were investigated in present work for two commercial biodiesel samples prepared with different raw materials (soybean oil or soybean oil with beef tallow). The presence of beef tallow in one of the samples was positive for this biofuel quality in all of the aspects analyzed. Curcumin proved to be an efficient antioxidant for both biodiesel samples, increasing the induction period and reducing the acid number, guaranteeing good oxidative stability for commercial biodiesels studied. DOI: http://dx.doi.org/10.17807/orbital.v11i4.1225


The information on heavy metals accumulation in Populus L. (poplar) species growing within the limits of Orenburg and in ecologically clean zones is reported in the article. Data on the content of ascorbic acid in the leaves of Populus nigra L., and silver-leaved poplar, Populus alba L., spread in different habitats are submitted.


Nowadays along with the development and progress the number of people who are taking up higher education is increasing. According to the data from 2008, which were published by the Central Office of Statistics, 1937,4 thousand people were students in Poland presently. A big part of these people leave their home places in order to start studying in other cities. It is concluded that the selected problems of students from the Faculty of Health Sciences which are concerned with taking up higher education beyond their home places were analysed. These problems involve personal difficulties and keeping single-handed households. Moreover, deficiencies of aid units responsible for helping students in personal, material, cognitive, organizational and adaptation spheres were discovered. In this way, this study discovers not only problems among students who are studying Nursing in Medical University of Gdansk, but also directions for the solution to these problems. It is extremely important for the quality of this study, because it brings ready-made ways of coping with the mentioned problems in the from of proposals for creating specialized aid units.


In this paper we present a management system for the Instructional Design Matrix (IDMatrix). The management activities consist in designing, planning, and monitoring the contents offered in semi presence-ased courses of the I (ederal Institute for Technological ducation of  eara - ra il). efore the implementation of this tool, the IDMatri x were conceived ust as a restricted document to certain people, and


This thesis analyzes the radio characteristic,the region geography characteristic and the radio transmission of the load management system.It's benefit to the system network construction of the load management system wireless channels.


The invention provides a protection method of a quartz tube. The quartz tube is used for a deposition apparatus adopting a chlorine-containing substance as a reactant. The protection method of the quartz tube comprises of removing hydroxy in the quartz tube and generating a fortifier of bond energy in the quartz tube. According to the protection method of the quartz tube, the hydroxy can be prevent from reacting with the chlorine-containing substance to form a yellow reactant through removing the hydroxyl in the quartz tube and the generated fortifier of the bond energy can prevent oxygen in quartz materials from reacting with the chlorine-containing material to form a yellow reactant, so that after the deposition manufacture procedure, the quartz tube is easy to maintain and preserve thereby prolonging the service life of the quartz tube; and the fortifier of the bond energy can also enhance surface characteristics of the quartz tube, making the latter maintenance not prone to damaging the quartz tube and ensuring the reliability of the deposition manufacture procedure.


Formation of magnetically ordered array of two types of rectangular nanorods, ∼300nm in length and a few nanometers in size, is achieved in the Mn-doped CoFe2O4 spinel through chemical phase separation mediated by cooperative Jahn-Teller distortions. At room temperature, the magnetic nanorods, with composition close to CoFe2O4, interlace with the paramagnetic counterparts and form a highly organized checkerboard pattern in the cross section. The checkerboard size in the range of ∼13.8×7.9–∼17.3×14.0nm2 is tunable with composition and, particularly, with the isothermal annealing time. These three-dimensional nanocheckerboards exhibit a nearly ideal configuration for the patterned perpendicular recording medium.


Besides explaining the different conception of nature, word, verb and temporality in Western and Hebrew culture, the thesis of this article is, first, that music in times of the Temple was essential in all aspects, sacred and profane, to Hebrew life. Second, after the Babylonian exile and during the Middle Ages, music was reserved only for singing the Bible at the synagogue. Third, this synagogue music, according to the nature of the Hebrew word, is essential to the correct understanding of the Holy Scripture, because in the Hebrew culture word and music are inseparable from one another, unlike the Western conception, according to which music is only an external accompaniment or adornment of the text. Fourth, with regard to the legality of profane music, in this period of exile, opinions are divided between rigorist and permissive rabbis.


The authors combine new observations of broad linewidths for C IV λ1548 and Mg II λ2800 in quasars with previously published widths. C IV λ1548 is systematically broader. The kinematics and geometry of the broad line-emitting gas evidently depend on the ionization level. A single photoionized cloud is therefore a poor approximation to typical conditions in the line-emitting gas. These results also suggest that the acceleration mechanism is less efficient for more optically thick gas clouds.


The contributions of this paper are twofold: first, a reverse engineering (RE) project is described while other educational projects based on existing systems have mainly focused on maintenance. Second, by means of an RE project, it became possible to approach real-world conditions more closely than in other types of educational software engineering (SE) projects.


Get to know the #1 rule for data specialists: Know thy data. Is it clean? What are the keys? Is it indexed? What about missing data, outliers, and so on? Failure to understand these aspects of your data will result in a flawed report, forecast, or model. In this hands-on workshop,  You will learn multiple ways of looking at data and its characteristics.  You will learn to leverage PROC MEANS and PROC FREQ to explore your data.  You will learn how to use PROC CONTENTS and PROC DATASETS to explore attributes and determine whether indexing is a good idea.  You will learn to employ powerful PROC SQL's dictionary tables to easily explore aspects of your data.


Conducted measurements of qualitative informative features for object recognition determined the most effective methods for measuring them. For this purpose, it is proposed to use the method of digital spectral analysis "thermal noise", which will provide a significant increase in resolution and measurement accuracy of object characteristics. Experimental studies have shown that to increase the likelihood of correct identification of objects by existing radio-technical identification systems, it is necessary to measure the highly informative characteristics of objects - their radar long-range portraits. Measurement of such portraits is proposed to carry out through the use of broadband and especially ultra-wideband signals, with high stability of the complex frequency characteristics of the receiving and transmitting paths of radar stations. In particular, the proposed structure of the construction of an experimental measuring complex and the principle of its operation for measuring radar distance portraits of identification objects.


I strongly recommend the book to anyone interested in the construction of meaning in practice. This book offers valuable supplementary reading to anyone interested in the topic, although it is best not to use it as the only source for courses devoted to the construction of meaning as more theoretical background is required. Nevertheless, the theoretical issues discussed in the introduction could also be very helpful for students in semiotics, particularly those interested in the differences between semiotics and semiology.


The association of maternal gestational diabetes mellitus (GDM) with childhood cardiovascular alterations is not well established. This study aims to test the hypothesis that prenatal exposure to GDM is associated with vascular and cardiac alterations in early childhood.


SETTING
Several matrix metalloproteinase (MMP) polymorphisms favouring the development of lung fibrosis after pulmonary tuberculosis (TB) have been described.

OBJECTIVE
To investigate the association of MMP-1, MMP-9 and MMP-12 polymorphisms with the development of fibrosis in pulmonary TB.

DESIGN
We studied 49 normal subjects and 98 TB patients. We analysed the association between MMP polymorphisms and clinical indices of lung fibrosis by serial chest radiography for 1 year after completion of treatment.

RESULTS
The frequency of the MMP-1(-1607G) polymorphism was significantly higher in TB patients with moderate to advanced pulmonary fibrosis than in those with minimal to mild fibrosis. Having at least one -1607G MMP-1 polymorphism increased the risk of moderate and advanced fibrosis respectively by 5.04 (95%CI 1.25-20.30) and 9.87 (95%CI 2.39-40.88) fold. There was no association of MMP-9(-1562T) and MMP-12(Asn357Ser) polymorphisms with lung fibrosis. The production of MMP-1 from monocytes stimulated by interleukin-1 beta was increased in subjects with the 1G allele genotype compared to the 2G/2G genotype.

CONCLUSIONS
Patients with MMP-1(-1607G) polymorphism are more vulnerable to more extensive lung fibrosis 1 year after anti-tuberculosis treatment. This may be related to increased MMP-1 activity, leading to enhanced destruction of the matrix with subsequent fibrosis.


A number of reports have described the isolation and characterization of bacteria that are capable of producing alginate lyase. These bacteria are expected to be used for preparation of alginates of low molecular weight with novel physiological and physical functions. They can also be used to produce single cell detritus from brown algal thalli for feeding of aquaculture animals. So far, the isolation of alginate-degrading microorganisms from natural environments and organisms has been carried out by enrichment cultivation supplied with both peptone and sodium alginate, followed by selection of alginate-degrading microbes on a plate containing sodium alginate as a sole source of carbon for growth. Therefore, this would reduce the time and effort to screen for the microorganisms with the aforementioned ability, if they are to be concentrated at the sites for collection of environmental samples. The purpose of the present study is to examine the effectiveness of a method intended to concentrate alginate-degrading bacteria in aquatic environments to avoid exhaustive screening in the laboratory. A test tube having nine holes in its surface was filled with 15% sodium alginate gel and immersed in the sea or brackish waters for three days, after which the retrieved gel was spread on the isolation plates which comprised nutrient agar and 1.5% sodium alginate. Subsequent analyses showed that 50% of the total bacteria which formed colonies on the isolation plates had alginate lyase activity. Of these, two bacterial strains were closely related to Cellulophaga fucicola NN015860 based on the 16S rRNA gene partial sequence data. The viscous alginate gel in the tube was assumed to have served not only as an absorbent for the floating microorganisms in aquatic environments but also as a primary carbon source for the bacteria that are capable of producing alginate-degrading enzymes. In short, the alginate gel may have concentrated the bacteria of interest at the sites where the test tubes were placed. Considering that most of the alginate-degrading bacteria described so far have been obtained from the algal thalli of the brown macro-algae, the method described here should be useful for effective isolation of alginate lyase-producing bacteria from aquatic environments during summer and autumn when most of the benthonic, macro-algal thalli disappear from coastal environments.


The conclusion about the absence in them of the mathematical means of the adequate description of passage from one inertial reference system to another because of the use by them of particular derived field functions on the time, which completely tie electrodynamic process to one concrete frame of reference, is made on the basis of the critical analysis of extraction from the equations of the electrodynamics of ideas about the space and period. Is proposed new approach to the development of the mathematical apparatus for electrodynamics in the direction of the more adequate description of passage from one inertial reference system to another due to the introduction into the examination of the trans-coordinate equations, which use new Galilean and trans-coordinate derivatives of field functions.


To solve the problem of the environmental pollution and loss of large molybdenum metal in a pickling of molybdenum concentrate,the method of replacing part of the nitric acid with sodium nitrate was used to remove impurities. Laboratory and industrialized experiment results show that using sodium nitrate instead of parts of sodium nitrate,first of all,could meet the needs of different specification products; Second,the flue gas emission reached standard; Finally,the soluble molybdenum content in the wastewater was reduced and the recovery of molybdenum metals was improved.