The arrangement graph A/sub n,k/, which is a generalization of the star graph (n-k=1), presents more flexibility than the star graph in adjusting the major design parameters: number of nodes, degree, and diameter. Previously, the arrangement graph has proved Hamiltonian. In this paper, we further show that the arrangement graph remains Hamiltonian even if it is faulty. Let |F/sub e/| and |F/sub v/| denote the numbers of edge faults and vertex faults, respectively. We show that A/sub n,k/ is Hamiltonian when 1) (k=2 and n-k/spl ges/4, or k/spl ges/3 and n-k/spl ges/4+[k/2]), and |F/sub e/|/spl les/k(n-k)-2, or 2) k/spl ges/2, n-k/spl ges/2+[k/2], and |F/sub e/|/spl les/k(n-k-3)-1, or 3) k/spl ges/2, n-k/spl ges/3, and |F/sub e/|/spl les/k, or 4) n-k/spl ges/3 and |F/sub v/|/spl les/n-3, or 5) n-k/spl ges/3 and |F/sub v/|+|F/sub e/|/spl les/k. Besides, for A/sub n,k/ with n-k=2, we construct a cycle of length at least 1) [n!/(n-k!)]-2 if |F/sub e/|/spl les/k-1, or 2) [n!/(n-k)!]-|F/sub v/|-2(k-1) if |F/sub v/|/spl les/k-1, or 3) [n!/(n-k)!]-|F/sub v/|-2(k-1) if |F/sub e/|+|F/sub v/|/spl les/k-1, where [n!/(n-k)!] is the number of nodes in A/sub n,k/.


Review: Water War in the Klamath Basin: Macho Law, Combat Biology, and Dirty Politics By Doremus, Holly and A. Dan Tarlock Reviewed by Victoria Carchidi University of Pennsylvania, Philadelphia PA, USA Doremus, Holly and A. Dan Tarlock. Water War in the Klamath Basin: Macho Law, Combat Biology, and Dirty Politics. Washington, DC: Island Press, 2008. 249 pp. ISBN 10: 1-59726-394-X. US $30 ppbk. Recycled, acid-free paper. In 2007, the Klamath Basin was named one of the best one hundred places to live in the United States. A prime reason is its spectacular beauty: high desert with a large wetland area. The Basin's national wildlife refuges support three- fourths of the Pacific Flyway's migratory birds, and provide major salmon spawning habitat. But it is not such a wonderful place to live in a dry year, when conflict arises over who has rights to the limited water. Birds and ecosystems; fish and the communities that live off them; farmers; and hydropower all struggle to survive. Doremus and Tarlock, both law professors, focus on the dry year of 2001, when irrigation headgates to the Klamath Project were closed. That action stemmed from the government's listing of the Klamath salmon and suckers under the Endangered Species Act (ESA). It led to such outrage that biologists removed government license plates from their vehicles for their own safety. Historical legacies fuel the ongoing tensions over water in the Klamath. The authors demonstrate that American attitudes toward the West, the drive to "settle" it, produced laws about land and water rights, about natural resources and our obligations and rights to them: "The basin's problems stem from a long series of decisions, taken in good faith, about how the area's water should be used." (184) The Basin is home to a number of minority cultures: farmers, recruited in part from World War II veterans; the Klamath and Modoc Indian tribes; the fishing communities of the lower basin, and many others, including the suckers that are failing to reproduce and other organisms unnamed and uncounted. The Klamath's constellation of communities is unique, but the problem it faces is not. As the authors note, 2001 is over, but dry years are a natural feature of the West. Further, water has become an increasingly contested resource not only in the


It is undeniable that the demand for locally processed root crops is low compared to commercial junk foods, affecting the income of both farmers and local processors. This study was conducted to ascertain the product attributes that influenced the purchasing decision of the consumers which serves as a basis for positioning the product in the market. It utilized a survey research design using a combined purposive and quota sampling techniques to select the respondents who are the target market of the product. This study collected market data and consumer preferences from 200 segmented respondents who are located in Baybay City, Leyte. Conjoint analysis was used to determine the attributes that highly influenced the buying decision of the consumers. Results show that product type highly influenced the buying decision of the consumers. Processed root crops that are locally produced are mostly preferred by the consumers over commercial junk foods. However, consumers are rarely buying the product because it is unavailable in the common market outlets. Given its high market potential, it is recommended to modify and improve the marketing strategies employed by the local processors. Tapping LGUs for promotion and other aid for complying with the regulatory requirements necessary for placing the product in the local and department stores is highly advised.


Phishing Websites steal confidential material like from digital users. They steal all information possible from an end user. They use different techniques to steal the data. Most of the internet users become victims across the globe due to lack of digital education. Most fake websites look like trusted and real websites. About 2.009 million Phishing websites are detected in 2020; this rises to 26.02 percent in 2021. Identity theft cases have doubled since early 2020. Normal users can't spot phishing sites. Detecting fake sites requires special tools. Detecting phishing websites used black-list/whitelist, knowledge, URL-based, visual-similarity, machine learning, heuristic methods. Models detect URL-analysis, Webpage code, Webpage text data, URL statistical data, website images, and content. This paper studied and reviewed Phishing website detection methods. Comparing models, techniques, and accuracy.


Due to the impact of adverse environmental factors, unsatisfactory conditions of pig population, deterioration of food supply, abuse of antibiotics, lack of preventive measures, leads to the development of diseases among pigs, especially young, which leads to a decrease in resistance, body performance, reproduction and reduction of livestock, as well as large economic losses. The use of bacterial preparations from living microorganisms can significantly reduce or even eliminate the use of antibiotics and hormones in the cultivation of healthy animals, to obtain high-quality and safe high-grade products. The aim of the work is to study the effect of probiotic EM – 1 on the physiological state and productivity of young pigs of large white breed. The experiment was conducted on two groups (6 heads each) of animals-analogues, starting from 60 days of age, for 2 months. Animals of the control group received feed produced in the farm. Piglets of the experimental group in addition to the main diet received 5% of feed fermented with em-1. Evaluation of the physiological state and productivity of young pigs was carried out on 60, 90 and 120 days of experience according to the methods adopted in clinical practice. Hygienic, hematological, biochemical, zootechnical and statistical methods of research were used in the performance of the work. The use of probiotic EM-1 in animals of the experimental group led to an increase in hemoglobine concentration by 7.7%, an increase in the number of red blood cells by 13.7%, the total number of leukocytes by 9.52%, and glucose concentration by 11.4%. The advantage of the viability of these pigs for the content of total protein (P < 0.05), γ–globulins by 18.6%, the activity of aminotransferases (AlАT, AsAT; P < 0.05), the average daily gain increased by 12.3% at the end of the experiment. For feeding piglets feed with probiotic EM-1 increased metabolic processes, resistance and productivity of the body, which indicates a higher level of redox reactions in their body.


Comment on "Critical states and fractal attractors in fractal tongues: Localization in the Harper map" [Phys. Rev. E64 (2001) 045204]


In this network era,the new changes,new situations and new trends have been taken places in literary and artistic production,transmission,consumption and so on.The performances of the update of creative artistic productions on the concept mainly include the emergence of new artistic styles,varieties of cross-integration transmission modes in the proceed of literary transmission,the blurring of the distinction,the principal of equal literary consumer links and the images trend.


Objectives The literature on patient safety in psychiatry has not been explored systematically in terms of what interventions are used, how they are used, and what type of (preventable) harm is targeted. The aims of this scoping review are to explore patient safety strategies used in psychiatry and determine how they construct the notion of preventable harm. Method A scoping review of literature on patient safety in psychiatry published in English between 2000 and 2019 was conducted using Scopus, MEDLINE, PsycInfo, and CINAHL. Keywords of patient safety strategies and possible outcomes were coded from the results, discussion, or conclusion. Patient safety strategies were inductively categorized into themes according to the focus of the strategy. Results The review introduces 7 focus areas of patient safety strategies identified within the psychiatric literature: "risk management," "healthcare practitioners," "patient observation," "patient involvement," "computerized methods," "admission and discharge," and "security." The result shows that patient safety strategies mainly aim to reduce suicide, self-harm, violence, and falls and present a large diversity of measures, often aimed at reducing variability while increasing standardization. Conclusions The strategies that are supported in the literature to achieve safer psychiatry mainly arise from linear cause-effect models and rely on staff performance, competence, and compliance. Contemporary safety science acknowledges the performance variability of everyday normal work and sees risk as the dynamic migration of these daily activities. The field of psychiatry has not yet included this view of safety in the strategic actions to reduce preventable harm.


The increasing difficulty of space exploration missions, human support and maintenance of infrastructure push the expectations for future robotic systems. Complex software systems are required to autonomously perform mobile manipulation and interaction tasks in a robust fashion. Component based software development and software frameworks provide a way for efficient implementation. This paper introduces the Rock framework, which uses a model driven approach to handle the complexity of component networks which can reconfigure at run-time. The Artemis Rover, which participated at the SpaceBot Cup competition is used as an example where the Rock framework has been successfully applied to a mobile manipulation system.


This is a multicenter retrospective observational study, using Clalit health maintenance organization integrated data. We studied unstructured data of 1,339 brain-CT reports of patients aged 50-80 years. Patients were categorized by the presence or absence of brain infarction in the brain CT report and then compared to the presence of stroke diagnoses in the corresponding patient EHR.


Objective: Patient-reported toxicities after breast radiotherapy merit understanding in order to inform decisions and target supportive care interventions. Methods: As part of a collaborative quality improvement initiative, the Michigan Radiation Oncology Quality Consortium prospectively collects patient-reported outcomes data from women treated for breast cancer at 26 practices across the state. Of all 11,107 patients treated with lumpectomy and whole breast radiation therapy between 1/1/2012 and 12/31/2018, 2817 refused patient surveys. We describe here the maximal toxicity reported by the 7689 patients who provided survey responses within 7 days of end of treatment and for whom we had sufficient data to determine dose-fractionation and treatment fields. Multivariable logistic regression models separately identified the individual and treatment characteristics associated with 1) breast pain, 2) a bother scale (related to itching, stinging/burning, swelling, or hurting of the treated breast), and 3) fatigue. Breast pain was considered moderate or severe when score ≥4 on modified 10-point Brief Pain Inventory measure. Bother from multiple breast symptoms was considered frequent when score ≥3 on a scaled measure (range 0-4) averaging responses on four items derived from the Skindex. Fatigue was considered severe when rated as present "always" or "most of the time" over past four weeks. Results: Moderate or severe breast pain was reported by 2882 (37.5%) overall: 1022 (28.3%) of those receiving hypofractionation (HF) and 1860 (45.7%) of those receiving conventional fractionation (CF). Frequent bother from multiple breast symptoms was reported by 1029 (13.4%) overall: 288 (8.0%) after HF and 741 (18.2%) after CF. Severe fatigue was reported by 1795 (23.4%) overall: 681 (18.8%) after HF and 1114 (27.4%) after CF. In addition to treatment fractionation (p Conclusions: In this large observational dataset of patient-reported toxicities after whole breast radiotherapy, substantial differences existed by radiotherapy dose-fractionation. Race differences in breast pain and bother existed despite controlling for multiple other factors, including age, body habitus, comorbidities, and treatment characteristics; further research is needed to understand what drives these differences in order to target potentially modifiable factors. Intensification of supportive care may be appropriate for subgroups identified as being vulnerable to greater toxicity. Citation Format: Reshma Jagsi, Kent Griffith, Frank Vicini, Jay Burmeister, Michael Dominello, Inga Grills, James Hayman, Jean Moran, Peter Paximadis, Jeffrey Radawski, Eleanor Walker, Lori Pierce. Identifying patients at higher risk of toxicity after breast radiotherapy: Analysis of patient-reported outcomes in the Michigan Radiation Oncology Quality Consortium cohort [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr PD6-6.


A new characterization for global hyperbolicity is given. The concept of cosmological time function and its regularity was considered by Anderson et al. ["The cosmological time function," Class. Quantum Grav. 15, 309 (1998)]10.1088/0264-9381/15/2/006 and it was proved that if the cosmological time function of (M, g) is regular then it is globally hyperbolic. In this paper it is proved that if (M, g) is globally hyperbolic then there is a smooth function Ω > 0 such that the cosmological time function of (M, Ωg) is regular. It is also proved that the cosmological time function of Friedman-Robertson-Walker spacetime ((a, b) × f H, −dt2 + f h), a, b < ∞, is regular and in addition the regularity of cosmological time function for this kind of spacetimes is stable in Lor (M).


In this paper, a direct flux and torque control scheme for industrial application is analyzed in order to emphasis the drive performance at standstill and in the low speed range. The control strategy utilizes the torque and rotor flux commands to determine the reference value of the stator flux. In order to improve the low speed performance a closed loop estimator is employed to evaluate the rotor flux. The validity of the control scheme is verified by simulations and experimental tests of an induction motor drive system.


Objective: To study the clinical treatment of breast cancer in women ≥70 years old. Methods: The clinical data of 21 patients aged 70 years and elder who were treated from Jan. 2002 to Oct. 2005 were analyzed retrospectively and literatures were reviewed.Results:The percentage of stage Ⅱ~Ⅲ was 85.7%(18/21). Tumor diameters were about 1.3~6cm, and the average diameter was 4.13cm. Of all the patients 17 cases had comorbidities. Curative resection was performed in 19 of the 21patients, including 15 modified radical mastectomy(78.9%) . Two cases refuse treatment. Thirteen cases had ER-positive tumor and 9 of them accepted adjuvant endocrine therapy. Conclusion: Elder women with breast cancer should be diagnozed and treated as early as possible. Sugical operation is the major means for the treatment of operable breast cancer and we should emphasize the importance of adjuvant endocrine therapy .


Cannabis has been widely used by humans over many centuries as a source of fiber, oil and for medicinal purposes. Its use was illicit in numerous countries, including Greece and Lebanon. "Karma Lemon", one of the newest cannabis strain originated from Italy, is selected in this study to analyze its components using various techniques starting from the extraction, isolation and identification of cannabinoids using separatory compounds and NMR techniques as well as the main important morphological traits of this strain to be harvested at an appropriate time for medicinal uses in Greece and later on, in Lebanon. Thirty different samples were selected from the field of respected "Hemp Way Company" in Thessaloniki and studied for morphological traits. These were related to the length of the plant at harvest time (1.809 m) needed for the use of combines and the weight of inflorescence (213.5 g fresh and 40.8 g dry) for oil or seed production. Three samples of Karma Lemon cannabis strain inflorescence were analyzed at the Laboratory of Pharmacognosy, School of Pharmacy, in the Aristotle University of Thessaloniki in Greece, after proper extraction and isolation using ethanol and other separation compounds. TLC and NMR techniques were used to visualize and identify cannabinoids present after isolation. Cannabinoid acids, CBG, CBN, THC, CBD and other cannabinoids were identified and isolated.


Experimental maize hybrids with various levels of resistance to the maize stalk borer, Busseola fusca (Fuller), were evaluated at different infestation levels during seasons of favourable and unfavourable rainfall. Limited plant resistance sufficed to reduce plant damage and yield losses significantly. In spite of plant damage being more severe during the unfavourable season, yield losses were less severe, which was attributed to a greater seasonal effect on undamaged than on damaged plants. Yield reduction by seasonal effects was shown to manifest as a constant proportion of attainable yield in the favourable season, independent of infestation level. The significance of the results is discussed in relation to the development of differentiated economic thresholds, in order to improve the predictive estimation of yield losses for various categories of yield potential.


The GDVI provides early warning signals of a growth crisis in the event of large external shocks in LICs. This tool relates the likelihood of a sharp growth decline occurring in the event of a large exogenous shock to various economic and structural variables. The resources, instruments and policy buffers needed to absorb or mitigate shocks are often unavailable in LICs or difficult to implement in weak institutional and policy environments. In this regard, the GDVI helps to ascertain the potential sources of vulnerabilities (institutional, fiscal and external) and constitutes a useful tool for pre-emptive policy action.


Considering the requirements of speech applications such as speech synthesis and speech recognition,in order to improve the naturalness of speech synthesis system,this paper have done the systematic empirical work of acoustic feature analysis on the different structured(single syllable,two-syllable,three syllable and more than three syllable)words which contains lateral /l/ in Uyghur language,and get some valuable conclusions.The experimental analysis was carried out on the basis of Uyghur Acoustic Database.We believe that the study of this project not only has high research value for further studying of the Uyghur natural language,but also has high research value for the study of entire Altay language family.


Genome Wide Associations Studies GWAS are a powerful strategy for the exploration adaptive genetic variation to drought stress in advanced lines in common bean with interspecific genotypes, yet they still lack behind in the use of arid multi-environments as the subregions of the Colombian Caribbean. In order to bridge this gap, we couple an advanced genotypes panel integrated with Common Bean (Phaseolus vulgaris L.) × Tepary Bean (P. acutifolius A. Gray) interspecific lines with GWAS algorithms to identify novel sources of drought tolerance across the subregions of Colombian Caribbean. One of the most important challenges in agriculture is to achieve food security in environments vulnerable to climate change which worsens with the passing of the years. The common bean, a key product of the food basket of vulnerable regions of the Caribbean is affected by the reduction in yield under drought stress. A total of 87 advanced accessions with interspecific lines were genotyped by sequencing (GBS), leading to the discovery of 15,645 single-nucleotide polymorphism (SNP) markers. Five yield traits were developed for each accession and inputted in GWAS algorithms (i.e. FarmCPU, and BLINK) to identify putative associated loci in drought stress. Best-fit models revealed 47 significantly associated alleles distributed in all 11 common bean chromosomes. Flanking candidate genes were identified using 1-kb genomic windows centered in each associated SNP marker. A pathways enriched analysis was carried out using the mapped output in the GWAS step for each yield traits indices. Some of these genes were directly linked to response mechanisms of drought stress to level morphological, physiological, metabolic, signal transduction, and fatty acid and phospholipid metabolism. This work offers putative associated loci for marker-assisted and genomic selection for drought tolerance in common bean. It also demonstrates that it is feasible to identify genome-wide associations with an interspecific panel of genotypes and modern GWAS algorithms in multiples environments.


It was difficult to analyze and evaluate product service system due to its high order,multi-loop,nonlinear and uncertain characteristics.Aiming at this problem,concepts as service,product service network and product service chain were defined,the product service system was described from different perspectives.According to complex network theory,the microcosmic constitution of product service system and coupling mechanism between services were analyzed from perspectives of cost,quality,time,reliability,stability and robustness.Meanwhile,the evaluation system for product service system was also established.The proposed system provided theoretical foundation for checking,monitoring and optimization of service organization.Effectiveness and feasibility of the evaluation system were verified by examples.


Abstract: An alternative combustion technology for HD diesel engines has been developed to operate the engine with PCCI (premixed charge compression ignition) combustion at low load, and combined PCCI and so-called lean diffusion combustion (LDC) at medium and higher loads, through development of technologies of multi-pulse injections and combustion chamber designs. The LDC combustion process covers the early phase mixing process, the rich premixed combustion process and the later phase mixing process. Enhancement of mixing is essential and critical to the LDC combustion. Countermeasures to enhance the mixing rate are discussed in relation to multi-pulse injection and combustion chamber design.


A new non-contact cyclic wave load generation system for centrifuge model test is developed.Through computer controlled load device,the system can simulate storm wave load on breakwater in deep water.The system solves the problems accounted in previous study such as difficulty in energy dissipation,generating additional constraint and mass,and applying of reversal load that is hard to be carried out.Then a new measuring and controlling system is developed for dynamic centrifuge model test,which contains four functional modules: high speed data acquisition,low pass digital filter for signal noise and interference removal,modified proportion integration differentiation(PID) load control and signal generation control.The system also optimizes load control and data acquisition functions in dynamic centrifuge test.The feasibility of non-contact wave load generation system is verified by suction caisson breakwater centrifuge model test.Test results show that the device can apply wave load accurately and steadily,and can adjust load amplitude randomly.Cyclic displacement characteristics of suction caisson breakwater under wave load are as follows:accumulated value and amplitude of dynamic tilt angle both increase;horizontal displacement amplitude increases notably;while accumulated value of vertical displacement increases significantly.Suction caisson breakwater has oscillation-rock coupled motion mode.


Cyber threats pose grave national security dangers to the US. Many cyber-attacks today are executed with ever-growing collection of malicious tools. Cyber threat intelligence (CTI) and malware analysis portals aim to provide knowledge and tools to help prevent and mitigate attacks. However, current CTI and malware analysis portals and techniques have been criticized for being too reactive as they rely on data collected from past cyber-attacks. Online hacker forums provide a novel source of data that can inform a proactive CTI and malware portal. This research demonstrates the AZSecure Hacker Assets Portal. This portal collects and analyzes malicious assets directly from the largely untapped and rich data source of online hacker communities by utilizing state-of-the-art machine learning techniques. This paper explores the development and evolution of the AZSecure Hacker Assets Portal. We also present key portal functionalities such as asset searching, browsing, and downloading, source code visualizations and code comparison analytics, and an interactive CTI dashboard.


Three cows within their 26th week of lactation (average milk yield: 15.7 kg/day) were used to determine the effects of starvation on 19 free amino acids (AA) of plasma, uremia and glycemia. For three successive days, blood samples were collected at hourly intervals from 09.00 am to 03.00 pm. From 1 month before up to the ist day of the sampling period, the animals were overfed in two equal meals (06.15 am and 03.30 pm) with a hay-based diet. On the 2nd and the 3rd day, only water was available. On the Ist day of fasting, muscle protein catabolism increased as suggested by an increase (P < 0.05) in mean plasma levels of 3-methylhistidine (MeHis, index of muscle protein catabolism in cattle), Asp, Gly, His, Lys and Ser. On the same day, mean plasma concentrations of Glu and Pro decreased (P < 0.05), possibly through an enhanced utilization of those AA for gluconeogenesis and/or energy needs as suggested by the maintainance of glycemia and the increase (P < 0.05) in uremia. On the 2nd day of fasting, further changes of metabolic parameters occurred: mean plasma levels of MeHis, urea, Arg and Leu still increased (P < 0.05); those of Asn, Asp, Glu, Met and Tyr decreased (P < 0.05); plasma Gly, His, Lys and Ser plateaued at high and plasma Pro at low levels. Unlike results reported in dry cow, plasma Ala, Gin, lie and Val did not increase during the fasting period. Furthermore, despite an enhanced protein mobilization, glycemia and milk yield dropped (P < 0.05) on the 2nd day of fasting. The fall in plasma glucose probably resulted from a continuous glucose uptake by the mammary gland for milk lactose synthesis which was not entirely compensated by gluconeogenesis. Within-day variations in plasma metabolites were observed, but these variations were generally lower during fasting than during feeding, especially for plasma glucose which showed variation with time of day during both fasting days. It was concluded that, as in dry cows, a 2-day fasting enhances muscle proteolysis in lactating cows. Contrary to dry cows, however, gluconeogenesis mechanism which attempts to maintain glucose homeostasis becomes insufficient in lactating cows to avoid a drop in glycemia from the 2nd day of fasting. The decrease in milk yield might be, at least partly, the result of that drop in glycemia. Finally, the time course from the last meal is a factor affecting within-day variations of plasma metabolites.


This paper aims to investigate intellectual capital management in a public organisation as the Chambers of Commerce; in particular, whether and to what extent intellectual capital contributes to overall accountability and what role intellectual capital plays as a management tool. In order to answer these questions, the paper examines a case study, the Chamber of Commerce of Verbania Cusio Ossola that, at present, is one of the few in Italy, which prepares an intellectual capital report, by dedicating to it a special section in its social budget, where IC is reported. The paper also describes the intellectual capital report used in the Chamber of Commerce, the information supplied and the role of intellectual capital management in this context explaining the value added it brings to the community.


The projection of cortical areas 17, 18, and 19 onto the laminar part of the dorsal lateral geniculate nucleus was investigated with degeneration methods and with the autoradiographic axon tracing method. In agreement with previous accounts, degenerating cortical axons stained by the Nauta method were restricted to laminae A, A1, C and to the interlaminar zones. In contrast, adjacent sections stained with the Fink‐Heimer method showed fine dust like degeneration throughout all of the laminae of the nucleus. Comparisons of Fink‐Heimer degeneration resulting from lesions of area 17 with that resulting from lesions of areas 18 and 19 further suggested that the area 17 projection is heavier and more uniform than the projections from areas 18 and 19.


Silicon tetramethoxide (TMOS) monomers have been dissolved in mixtures of methanol and water, hydrolyzed, and condensed to form siloxane polymers. The various oligomers which form during the early stages of the reaction have been identified through high-resolution {sup 29}Si NMR with polarization transfer. At low water/alkoxide ratios the hydrolysis is incomplete and limits the condensation reaction. Small cyclics are formed in addition to linear polymers. At high water/alkoxide ratios, the hydrolysis is fast and complete and the condensation is rate limiting. The polymers are largely branched as indicated by the high proportion of Q{sup 3} chain branching sites and Q{sup 4} three dimensionally cross-linked groups. So highly condensed species including small rings or cagelike structures can be expected in these mixtures.


To the Editor: Acquired amegakaryocytic thrombocytopenic purpura (AATP) is a rare disorder characterized by severe thrombocytopenia and marked decrease or total absence of megakaryocytes in the bone marrow. The clinical course is variable and some cases have been reported to progress to aplastic anemia, myelodysplasia or leukemia (1, 2). A variety of pathogenetic mechanisms have been suggested so that no standard treatment has been stablished. I report a case of AATP successfully treated with a limited course of cyclosporin A (CsA). A 20-yr-old woman with an unremarkable medical history presented in May 1998 with a 11-month history of easy bruising. Physical examination only revealed scattered petechiae and ecchymosis. Her white blood cell count was 5.5 · 103 lL, hemoglobin 12.25 g dL, and platelet count 22 · 10 lL. Bone marrow aspiration and biopsy showed a slightly reduced cellularity with absence of megakaryocytes. Erythroid and myeloid elements were normal. Bone marrow cytogenetic study revealed normal karyotypes. Screening for platelet antibodies, antinuclear antibodies (ANA), and single-stranded DNA antibodies were negative. Parvovirus B19 serologies were negative. A computerized tomography (CT) scan of the thorax was normal. She was diagnosed as having AATP. Treatment with prednisone (1.5 mg kg d) was started, but over the next 2 wk her platelet count dropped to 7 · 10 lL. Prednisone was tapered off while a course of intravenous immunoglobulin (1 g kg d for 2 d) was given without response. The platelet count only rose after platelet transfusions. At this point, thrombopoietin (Tpo) levels were 8.55 fmol mL. Oral CsA (5 mg kg d) was initiated 35 d after diagnosis, and its dose was adjusted to keep levels between 200 and 300 ng mL. One month later her platelet count progressively increased, and stabilized around 50 · 10 lL 8 months after the initiation of CsA. We saw a tight correlation between CsA levels and platelet count during treatment (Fig. 1). Nonetheless, after 12 months on CsA the drug was stopped and the patient's platelet count was closely monitored. Shortly after CsA cessation platelet counts dropped slightly over the next 2 months, but then stabilized, ranging currently from 50 · 10 to 70 · 10 lL. Her clinical course was completely unremarkable. On her last observation in May 2002 the patient was doing well, off medication, and with no bleeding diathesis. Good responses to therapy in AATP patients have been mostly achieved using immunosuppressive agents such as CsA or antithymocyte/antilymphocyte globulin (3, 4). Our case illustrates the benefits of a limited CsA course. This benefit is twofold: first, we achieved a partial remission, keeping platelet counts within a range in which bleeding complications rarely occur. Secondly, it is well established that CsA increases the risk of cancer (by suppressing immune response and by a direct cellular effect) and infectious complications. Stopping CsA after 12 months limits the possibility of occurrence of these and other undesirable side-effects. Further studies are warranted to define better the pathogenesis and therapy of this poorly recognized


intRoduction Delirium is a common complication of critical illness. It has conventionally been regarded as an unavoidable and benign side effect of long-term sedation on an intensive care unit (ICU). However in recent years this pre-conception has been challenged by the publication of studies demonstrating poorer outcomes in ICU patients with delirium. This article will define delirium, summarise the risk factors, provide an overview of the current evidence for its detection and discuss its management. Summary


Results of measurements made using the multipole wiggler at beamline 16 of Photon Factory are reported. Double crystal rocking curves, Si(111) and Si(333) topographs, and thermal maps of the cooled‐crystal surface were measured at total incident power levels up to 1600 W and power densities up to 0.7 W/mm2, for two different crystal designs. Significant crystal deformation occurred in the form of surface curvature for both designs. Finite element calculations provided a preview of the experimental results and proved very valuable in interpretation of the measurements.


Background: In environmental epidemiology, the question of whether epigenetic processes might mediate environmental health effects is an intriguing one. The advent of the Illumina Infinium HumanMet...


Laser rapid solidification experiments were performed on Nd13.5Fe79.75B6.75 hyperperitectic alloy to investigate microstructure evolution.The results show that at scanning velocity higher than 2 mm/s,peritectic T1 phase directly precipitates from the liquid instead of by peritectic reaction.Using KGT model and the maximum growth temperature criterion,critical velocity for the transition from primary γ-Fe phase to T1 phase is calculated to be 0.34 mm/s,which approaches the experimental value of 2 mm/s.High velocity banding structure,showing oscillatory plane front and cellular microstructures,is firstly detected in Nd13.5Fe79.75B6.75 peritectic alloys.The growth velocity for banding structure is deduced to be in the range of 100-500 mm/s.The experimental appearance of the banding structure agrees well with the theoretical prediction.


In developed economies, consumers have been saying it loud and clear: Corporate social responsibility (CSR) is a must, not a nice-to-have. As far back as 2010, more than 88 percent of consumers thought firms should improve society and the environment. The trend has hardly abated. A 2018 survey conducted in the United Kingdom and the United States revealed that the overwhelming majority of consumers now count on brands to help them be more environment-friendly in their own daily lives.


Experimental vibrational spectroscopic studies and density functional theory (DFT) calculations of the amino acid derivatives N-acetyl-L-Asp and N-acetyl-L-Glu have been undertaken. Raman and IR spectra have been measured in the solid state for both molecules. DFT simulations were conducted using the B3-LYP correlation functional and the cc-pVDZ basis set in order to determine their energy minimized/geometry optimized structures (based on a single isolated molecule in the gaseous state), and vibrational spectra were computed at the optimized geometry in each case. Normal coordinate calculations have provided vibrational assignments for fundamental modes, including their potential energy distributions. Significant differences are observed in the computed structures and in the vibrational spectra of N-acetyl-L-Asp and N-acetyl-L-Glu. The combination of experimental and calculated results provides an insight into the structural and vibrational spectroscopic properties of N-acetylated amino acid derivatives.


A cutinase from Thermobifida fusca WSH04 and two lipases, L3126 and Lipex 100L, were applied to the enzymatic pretreatment of wool fabrics followed by protease treatment, aiming at hydrolyzing the outmost bound lipids on the wool surface. A mild oxidation with 2 g/L hydrogen peroxide (30%) was selectively carried out before the enzymatic treatments. The cooperative actions of mild oxidation, cutinase and lipase pretreatments during wool processing were investigated. The results showed that lipase pretreatment alone had less impact on the wettability and anti‐felting ability of wool fabrics than cutinase treatment. Combined use of cutinase and lipase pretreatments did not evidently improve the properties of the wool fabric compared with the individual cutinase pretreatment. By contrast, mild oxidation slightly enhanced the activity of cutinase toward the wool surface and promoted the subsequent proteolytic reactions. The wetting time and contact angle of the protease‐treated fabric deceased to 1.2 min and 55°, respectively; the area shrinkage decreased to 3.1%, with an acceptable strength loss from 489 to 418 N. The changes in the cuticle scales of the wool fibers, confirmed by scanning electron microscopy, further proved the cooperative actions of mild oxidation and cutinase pretreatment during enzymatic wool processing.


In this paper, we present progress in the application of the explicitly time-dependent multi-configuration time-dependent Hartree–Fock (MCTDHF) method. The spin–orbitals and equations of motion are expressed in the basis of Gaussian Type Orbitals. MCTDHF is then applied to the calculation of the electronic ground state of various small molecules by imaginary time propagation. We were able to take between four and 12 active electrons into account. We discuss the suitability of a core guess as initial wave function, the possibility to obtain excited states, as well as the consequences of a neglect of core excitations.


Digital Images of Oxford, Bodleian Library MS Bodley 221, containing a fifteenth century scribal copy of Thomas Hoccleve's Regiment of Princes.


The purpose of the thesis is to question the hegemony of auteurist, director-based
criticisms of Shakespearean films by rescuing the film-editor from anonymity. By
drawing my attention to the determining, yet largely disregarded work of editorial
creation, I offer a reading of a selection of Shakespearean films that acknowledges the
centrality of collaborative work in representing Shakespeare on film. In order to
recreate the editor as a 'collaborative auteur', I propose to trace the authorial
signature(s) of the editore(s) by examining and identifying in which ways and according
to which specific patterns the Shakespearean pre-texts are transformed into
'Shakespearean' film texts.


Graphene is widely used in various real-life applications due to its high sensitivity to the change in the carrier concentration. Here, we demonstrate that graphene can be used for implementing a reliable lightning detection network as it shows excellent sensitivity to the electric field of both positive and negative polarities, with a wide range of magnitude. The lowest electric field detected by our graphene sensor is 67 V/m, which is much smaller than the detection limit of previously reported graphene sensors and comparable to that of field mill and MEMS-based sensors. We also present the results of outdoor experiments where the response of the graphene sensor to the atmospheric electric field on a lightning day was tested and found to be in good agreement with the existing field mill sensor.


As a result of structural reform of Russian railways, a host of agents those provide customers with loading resources. These processes reduce in efficiency of the car fleet, increasing transportation costs, shortage of cars for many customers, an increase of empty runs and, as a result, a depletion of a number of sections of the network carrying capacity at a reduced total volume of rail traffic. According to the authors, the reason for this situation is the mismatch occurred heterogeneity of rolling stock to existing planning conditions and tariffs. It is established that the inefficiency of decentralized car fleet contributes to the predominance of tree-type network, and the importance of this factor in the new environment has increased substantially. To ensure the efficient operation of rail transport as a systemic industry, providing mass-haul transport, it is proposed for integration into a regional logistics. It is also shown that freight terminals regional logistics transportation and distribution system (RLTRS) is appropriate to create on the basis of major freight railway stations.


For more than ten years, modern psychology and pedagogy have preferred effective and original educational tools, the main purpose of which is to reveal the potential of modern art, the development of critical thinking that can be used in the study of various school subjects. Modern society, like life, is very demanding, it needs citizens who are able to think flexibly and dynamically, are able to navigate the variability of life, can make unusual decisions. Critical thinking of contemporary art is a jewelry tool for understanding the new educational paradigm focused on the adaptation of free communication in the world. Life proves that thanks to creativity, flexibility, the ability to generate new ideas, society will be easier to navigate in the most difficult times. How to prepare primary school students for life activities and fruitful work? Why should teachers and their students understand contemporary art? Scientific research (Kolotilo O.) proves that the main tasks of teaching an integrated course «art» are to reveal creative talents, stimulate artistic and figurative thinking, education of aesthetic taste of the individual in early school age and later independent life. In the process of a brief review of the history of modern art, the development of cultural values, the development of artistic and figurative thinking is formed on the basis of the idea of «beautiful». The demand for creative, intellectually developed people is very high.The classification of types of thinking has its origins in the works of Aristotle, who built the sphere of «speculation» and «pure reason» on a system of universal abstractions. Psychologists, in turn, consider several types of thinking: visual, concrete and abstract, intuitive and critical thinking. The scientific prism of intellectual and practical activity emphasizes the unity of thinking with the feelings of perception of the world around. Thanks to critical thinking, the child goes beyond sensory cognition. L. Masol, S. Zhupanin and F. Shchegel agree that the methodological basis for understanding the essence of the artistic image are the philosophical provisions of the theory of knowledge, interpret thinking as a holistic expression of human essence, where feelings and imagination provide diversity of implementation. Each of us is an artist, and creativity brings us great pleasure. In art, a person gets many opportunities to express their feelings and emotions. Creative talents in children are no longer perceived as internal uncontrolled processes. Creativity – a constant companion of child development, and in a broader sense – a necessary condition for existence. With the help of an integrated art course introduced by the New Ukrainian School, primary school students expand their knowledge of the ideas and features of contemporary art and develop skills to implement various components of contemporary art in their professional activities. Key words: critical thinking, creativity, subject learning, creativity, abilities, art, New Ukrainian School


The purpose of the present invention is to develop a kit capable of detecting or measuring an antigen at high sensitivity without requiring an immobilization step or a washing step. The present invention provides a kit for detecting or measuring an antigen, the kit comprising: a conjugate composed of a polypeptide including an antibody light chain variable region and a polypeptide including an antibody heavy chain variable region; and a fragment of protein M marked with a fluorescent pigment, wherein the fragment of protein M is a fragment having the ability to bond with the conjugate.


Liolaemus barbarae is a small liolaemid lizard (SVL: 56 mm) endemic to the high Andes of northern Chile. Diet and prey availability were assessed during three seasons of activity (spring 2003, summer 2004, autumn 2004) in order to determine patterns of prey consumption and eventual selection. Liolaemus barbarae was strictly insectivorous preying on flying and epigeous insects, mainly chinch bugs (Lygaeidae) and ants. Prey types were consumed in different proportions than available in the environment. The selection for Lygaeidae, the most frequent prey consumed, was inversely correlated with their availability suggesting a nutrient-optimization strategy. Ants acted as complementary prey but they were less consumed than available. Despite the harsh environmental conditions, this Andean lizard seems able to fulfil its trophic requirements, its annual diet being less variable than the seasonal fluctuations of insects in the environment.


Objective To explore the method of treatment for cirrhosis associated portal hypertension and hepatogenic diabetes.Methods The clinical data of 46 cases of cirrhosis with portal hypertension and hepatogenic diabetes treated in recent 10-year period were retrospectively analyzed.Results All the patients received operative treatment after basic nutritional support and adjunctive insulin therapy.Surgical intervention included portoazygos veins devascularization procedure in 39 cases,and devascularization combined with splenorenal shunt in 7 cases.Results showed that the hepatogenic diabetes improved in 39 cases(84.8%).Conclusions Patients with cirrhosis and hepatogenic diabetes should have treatment directed to the primary disease and mainly to aggressively improve live function,and additionally treat the abnormal glucose metabolism.


PTU UB™ is a new generation of high-performance polyurea coating and is the result of six years of development and field testing. This chemical ...


This article argues that Mohsin Hamid's How to Get Filthy Rich in Rising Asia functions as a strategic parody of a self-help book that comments on economic globalization's failures and in turn illustrates the violence that it produces. Although globalization is detrimental to individuals and relatively inescapable within the world of Hamid's text, opportunities for reading creatively can counter its detriments. Hence, creative ways of reading provide alternatives to buying into the globalized and ever-globalizing capitalist system — alternatives that Hamid suggests his readers should embrace.


Understanding of natural convection of miscible two phases in porous media is of great importance to problems of geological storage of carbon dioxide. We consider saltwater-freshwater fingering instabilities in a saturated porous medium. Plastic resin particles with an average diameter of 320 μm or 440 μm were packed 50 mm in height in a tube with the inter diameter of 32 mm. Development of the fingering due to instabilities and natural convection of freshwater and saltwater in porous media have been imaged by means of micro-focused X-ray computer tomography (CT) every three minutes. At early stages of convective mixing, ripples appear on the contour surface of the concentration of sodium iodine and grow to be fingers which extend vertically downwards with time. As fingers proceed downwards, the concentration of sodium iodine in fingers are reduced. As a result the convective mixing is rapidly suppressed. With an increase in the density difference and the permeability, the development of the natural conve...


New experimental results for the vapor−liquid equilibrium of the system (water + methanol + sodium sulfate) are presented at (salt-free) solvent mixture methanol mole fractions from about 0.036 to ...


This is an excellent survey of recent work in Anglo-American ethics. It starts with Moore, moves on to Prichard and Ross, then to emotivism (largely taken up with Stevenson, comparatively little of Ayer), and on to the conflict between prescriptivism, as represented by Hare, and descriptivism, as championed by Mrs. Foot, principally, with some consideration of the views of G. J. Warnock. The book concludes with a chapter on the free-will question, the last pages of which are especially rewarding (Hudson's thesis about the possibility of linguistic reform in this area, should the notion of free will turn out to be illusory, is strikingly reminiscent of one of the arguments advanced on behalf of free will by Sir Isaiah Berlin in Historical Inevitability (1954). Hudson refers instead to Wittgenstein's idea that language-games can become obsolete and be supplanted, and to the contrast between science and superstition as explanatory models. There are, however, some drawbacks. The views of Toulmin, Paul Edwards and Singer are not even mentioned; while both Baier and Nowell-Smith are given short shrift. Studies of the free-will question such as Gahn's excellent book on Fate, Logic and Time (1967) or a recent anthology by Lehrer (1966) are not discussed. But it is not possible to talk, let alone equitably, about everything. The book is excellently written (except in two spots: Austin on free will (pp. 345-350), and some extra comments on Hare's neustics and phrastics (pp. 231-234), both of which are technical, involved and end up in obscurity). It is also, for the most part, excellently argued. I do not share Hudson's view of moral philosophy as meta-ethics (pp. 1, 12-13) but this is not a matter for a reviewer to pick on. I wish that Hudson had said more about utilitarianism (pp. 215-217), instead of restricting himself to Hare's exploration of the subject, in Freedom and Reason; but at least this is a subject which has been excellently covered elsewhere. The section on situation ethics (pp. 213-215) is exceedingly trenchant. The discussions of Hume on is-ought (pp. 249-265) and of Searle's derivation (pp. 282-291) are models of exposition, and quite properly placed within the context of Hudson's chapter on descriptivism. Hare's reply to criticisms (pp. 294-304) is elegantly and perceptively handled. The book as a whole is well organized, well developed, and will be of immeasurable assistance even to readers already familiar with the topics and material covered (this is especially true of


The effects of nutrient enrichment on density, biomass and on the relative contribution of pigmented and heterotrophic flagellates to the total abundance of all flagellates associated with Eichhornia crassipes were evaluated through mesocosm experiments over 33 days. Two triplicate treatments (nitrogen and phosphorus addition and a control treatment) were colonized, producing six mesocosm systems. The only variable that showed significance was flagellate density. Density increased significantly with increased nutrient concentrations in both flagellate groups, suggesting the importance of bottom-up control mechanisms. However, the time lag and the low magnitude response to density, as well as the lack of significant variation in biomass with respect to fertilization, suggested that a complex relationship is responsible for influencing the structure of flagellate communities associated with vegetation during nutrient enrichment in these food webs. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)


The experiment researched the changes in biological property and antioxidant activity of winter-jujube ferment during fermentation process. The results were as follows: reducing sugar content was increased first and then declined,soluble solids content and pH values were both decreased while the titratable acidity was increased.With the increase of biomass,the reducing power,scavenging capacity to hydroxyl free radical and SOD activity were also improved. However,there were no significant changes in flavonoids content before and after fermentation.


Purpose: The transfer of the human cornea from a donor to the artificial storage media is accompanied by the transient stress response of the cells reacting to the traumatic change of the environment. The aim of this study was to investigate cellular stress-mediated changes in the tissue at the metabolic level. Methods: Eight human corneas were obtained post-mortem from 58-67 year-old donors and stored in Eusol-C at +4°C for 3 days. The daily changes in metabolic profiles of the samples were investigated with HR MAS 1H NMR spectroscopy. Results: 24 metabolites were assigned in the corneas. The significant differences in metabolic profiles between the preserved and non-preserved tissues were observed for ATP, butyrate, formate, glutamate, methionine and phenylalanine. Conclusions: The transfer of the human cornea from its natural environment to the storage media causes the metabolic changes appearing during the first days of the preservation. A further research should explain if they are temporary or they could have an impact on the graft survival in recipients.


In the circulation domain of our country ,it has been for a long time that internal trade and internation trade have been separated.With the development of market economy,it is necessary to expedite the integration of internal and international trade.At present long-range layouts should be made and implemented in various aspects agradually in order to expedite the integration process,mainly including such approaches as endowing businesses of internal trade with the authority to deal in international trade,emphasizing the organization innovation of international trade businesses,developing large-scale circulation group and strengthening the cultivating of versatile talents.


The invention relates to an ultrasonic sensing device (1) for a motor vehicle, comprising an ultrasonic diaphragm (3), with an actuator (4) for moving the ultrasonic membrane (3) and with a control device (7) for driving the actuator (4), wherein the ultrasound sensor device (1) including a storage device (9), in which a production date of the ultrasonic sensor device (1) is stored, and the control means (7) is adapted to an age of the ultrasound sensor device (1) based on the stored production date to be determined.


James Goodman 1 , Jonathan Paul Marshall *, 1  and hampers the development and use of new technologies. Similarly, old social habits may remain, as when corporations install renewable energy with harmful consequences, even if those consequences are less deleterious than for fossil fuels. Different narratives about energy transition compete for local, national and international recognition. Technocratic narratives assume transitions can be managed by inevitable 'innovation' and 'green alternatives', while behavioral narratives assume lifestyle is central and needs to be drastically changed to reduce energy and material consumption. Other narratives emphasize the need for decentralized locally adapted solutions, while others attempt to design centralized, global solutions. There is a debate whether adequate changes can result from market incentives or need direct policy interventions such as deadlines for phasing-out coal or promotion of state-run renewable energy.


Simple Summary We compared the foraging techniques of Common Buzzards and Rough-legged Buzzards on their wintering grounds in east-central Poland. Both buzzard species spent the most time standing on the ground, less perching on trees and even less perching on fence posts. The difference in the hunting behaviors of the two species is associated with the use of small fence posts around pastures as hunting sites, which were conspicuously avoided by the Rough-legged Buzzards. Snow cover was the only weather factor in both buzzard species that affected foraging behavior and possibly intensified interspecific competition. Abstract Birds wintering in the northern Palearctic compensate for substantial energy losses and prepare for a food deficit in winter by adjusting their foraging behavior. Apart from weather conditions, interspecific competition also drives hunting strategies. To describe this phenomenon, we observed the behavior of two sympatrically wintering raptor species: the Common Buzzard and the Rough-legged Buzzard. The study was carried out in east-central Poland during four seasons on a study plot where the densities of both species were high. Interspecific differences were detected in the use of available hunting sites. Rough-legged Buzzards conspicuously avoided using fence posts for scanning the surroundings and spent the most time standing on the ground. Common Buzzards more often used trees for this purpose when the snow cover was thick. Thicker snow cover resulted in fewer attempted attacks on prey in both species and caused Common Buzzards to change their hunting sites less frequently. The study also showed that the more often a bird changed its hunting site, the greater the number of attempted attacks. The outcome is that the ultimate effectiveness of hunting is mediated by the overview of the foraging area from different heights and perspectives, not by the type of hunting site. Snow cover was the most important factor in modifying foraging behavior and possibly intensifying interspecific competition.


Atmospheric pressure is one of the most significant disturbing noises to surface gravity measurements. This effect is usually removed by two different methods that are based on the availability of pressure data and their distribution in both time and space. The first and most accurate method is the convolution of the global surface pressure field with an appropriate Green's function; its downside is that it requires short sampling intervals currently unavailable. The second method determines a transfer function between pressure and gravity known as barometric pressure admittance. In this paper, we adopt an alternative approach for the determination of the admittance that is based on the least-squares (LS) product spectrum of the atmosphere pressure and gravity time series. It represents a reasonable gravity response to air pressure fluctuations in specific frequency bands (frequency dependent admittance), that is derived from a fiveyear data set from the Canadian Superconducting Gravimeter Installation – CSGI (Cantley, Canada). The results show improvements in the gravity spectrum, particularly in the diurnal and semi-diurnal bands and in higher frequency bands.


As the "public man", how important a role the government plays depends on the government's efficency. The article makes a necessary definition and analysis of the importance and urgency, the specific characteristics and gradation of government efficency from three sides, and reveal the internal rule.


Pullman defines as "the space that opens up between the private mind of the reader and the book they're reading" (216). Taken individually, the chapters in this stimulating volume deliver engaged and comprehensive discussions, provide innovative theoretical and methodological approaches, and offer fresh insights into studying children's books. Taken together, they advance an exciting vein of children's literature scholarship. As the editors themselves point out, the collection is by no means meant to be exhaustive; rather, its goal is to provide a model and impetus for future research. Offering a multifaceted discussion of its subject matter, this highly readable volume manages to get a serious scholarly conversation underway and create space for other researchers to fill in the inevitable gaps. Accessible in both content and style, Space and Place in Children's Literature, 1789 to the Present will primarily be of use to students and scholars of children's literature, cultural geography, and childhood studies, but is likely to draw the attention of researchers working in other fields as well. Nada Kujundžić


Hard on the heels of volume 1 of The Cambridge History of American Literature, which covered early American literature from initial European contact with native peoples through the early Republic, comes this volume, devoted to all forms of prose writing in the antebellum period. Those who found the first installment of this long-awaited series a useful, though hardly complementary, collection of monographs should be more pleased with this effort, for herein the general editor has assembled four sophisticated contributions that reassess the remarkable literary achievement of the period.' Keeping his introductory comments to a minimum, Bercovitch sets the agenda by reiterating what he observed in the first volume in the series. Briefly put, he argues that, as we approach the millennium, consensus about America's literary history has broken down and been replaced by dissensus, with any invocation of the former sounding "rather like an appeal for compromise, or nostalgia." Further, "what used to be a relatively clear division between criticism and scholarship, aesthetic and historical analysis," he observes, "has blurred and then subdivided over and over again (in various combinations) into a spectrum of special interests" (p. 2). Thus, with American literary history now defined "in the plural," each contributor was given free rein to approach relevant texts through whatever points of view seemed to him or her most productive, the whole volume integrated mainly through the ways that each scholar's authority would complement that of the others. Happily for posterity, the intellectual gamble worked well; the book's four sections are a hand difficult to beat for an overview of antebellum prose. The volume succeeds so well because of the strength of each contribution, for, as Bercovitch had hoped, all four scholars demonstrate themselves in full control of general methodologies as well as the range of prose literature germane to them. So what do we have here? Michael Davitt Bell contributes a piece on "The Conditions of Literary Vocation," essentially an overview of the literary marketplace or, as Bercovitch puts it, "an inside narrative of literature


A stacking assembly of fuel cells detemperatura solid oxide intermediate (1) comprising: (i). a base plate (40); (ii). a bell (50) sealingly attached to said plate 5 basey defining a volume bell (60) between said placabase and said hood; (iii). at least one stack of fuel cells oxidosolido intermediate temperature (10) mounted on dichaplaca base and enclosed by said hood; (iv). at least one gas inlet (120) defining at least aPoint gas inlet (125) in said hood volume; and V). a preheater (200) located outside said numberof hood and in fluid communication with a deoxidante and said source at least one gas inlet and adapted oxidant parasuministrar (140) from said source of adicho oxidant volume hood through said gas inlet, each stack comprising fuel cell stacks at least trescapas fuel cell (20,21), comprising cadacapa stacking fuel cells at least one cell decombustible solid oxide intermediate temperature (30), defining cadacelda fuel an inlet end oxidant and desalida oxidizer exhaust (140a) end, said at least one stack of fuel cells: (a) at least one gas inlet open collector (70) defining unextremo open collector (80) of said at least one fuel stacking deceldas; and (b) at least one gas outlet internal manifold, said at least one entry point gas in said volume campanasituado away from said end open collector of said at least unapilamiento fuel cell so that the oxidant use entraen said volume hood through said at least one input gasy passes around the outside of said at least one stack of decombustible cells towards said at least one gas inlet open collector, resulting in a direct heat transfer between said oxidant and external lasuperficie (170) of said layers of stacking decombustible cells prior to entry of said oxidant into said inlet open decolector gas, said preheater formaque being configured in use oxidant from said oxidant source is heated and supplied adicho volume bell through said at least one gas inlet auna temperature not exceeding 100 ° C below the temperature operati vaen use in the inlet end of the fuel cell nearest Laal least one gas inlet open collector, wherein said at least one stack of fuel cells oxidosolido intermediate temperature defines a height X measured from the layer deapilamiento fuel cell (20) closest to said plate basehasta layer stack of fuel cells (21) remote dedicha base plate, and wherein said at least one point gas inlet estasituado at a height Y of said stacking layer closest to said base plate decombustible cells, which 0.25X = Y = 0.75X.


Abstract Research has devoted considerable attention to the contribution of cultural and creative industries (CCIs) to economic growth and innovation. Measuring and evaluative tools have played an increasingly important role in meeting the demand for the accountability of public money supporting this sector. Nevertheless, creativity remains an elusive subject for policy-makers. One of the major obstacles in adopting CCI policies is the difficulty in apprehending the value of support actions for cultural and creative enterprises. The present research is a first attempt to create a harmonised and simple set of indicators (the 'benchmarking raster') to assess local policies targeting economic development of CCIs. It has been completed in the framework of the INTERREG- funded CREA.RE network with the aim to encourage the authorities of small and medium-sized cities and regions to further invest Structural Funds in CCIs. It is also expected to contribute to CCI-focused economic development strategies (or Smart Specialisation Strategies).


 Abstract— Thermal power plants in India are facing the problem of forced outages due to unexpected boiler tube failures. Fly Ash Erosion (FAE) is one of the prime reasons for these failures. The main cause of this FAE is the localized increase in the velocity of flue gases which in turn increases the velocity of fly ash particles. The rate and extent of FAE depends on various parameters such as particle velocity, angle of impact, particle composition, shape, size & sharpness factor, temperature of particle, surface temperature of tube, population density of particles, coal quality, combustion efficiency, erosive resistance of the tube surface including compositional & temperature variations. Particle velocity is the most important parameter as the rate of erosive loss is proportional to the velocity raised to an exponent that ranges between two and four. Particle velocity is driven by the local flow velocity at any particular boiler location. It is difficult to physically measure velocities of flue gases inside the boiler when it is in operation. However, it is required to know the velocity flow field in various zones so that its effect on the various failure mechanisms can be predicted. The primary tool to combat Fly Ash Erosion is flow modification in conjunction with a cold air velocity test before and after modification. The cold air velocity test is performed to predict the velocities in the respective zones of the boiler. A comprehensive EPRI Guideline has been published which provides a step-by-step procedure of CAVT. In this paper authors have used cold air velocity technique (CAVT) to determine local velocity profiles across various pressure parts. The use of CAVT to identify regions of excessive velocity, followed by the installation of diffusion and distribution screens, may provide utilities with the most optimum solution to the problem. The authors have tried to predict the Cold Air Velocity. The actual geometry of the flue gas path of the 210 MW boiler is created using Pro-E and meshed using GAMBIT is imported in FLUENT for analysis. The inlet and outlet are given pressure boundary conditions. The k-epsilon realizable is used as turbulence model. The results obtained are then compared with the experimental data of CAVT to validate the model. For comparing the results, the points where the actual CAVT is performed are replicated in the simulated model. Cold Air Velocity Test is successfully simulated using FLUENT. The results of the simulation are in good agreement with the experimental results of CAVT with error of order of ±23 %.


Amateur soccer statistics have interesting applications such as providing insights to improve team performance, individual coaching, monitoring team progress and personal or team entertainment. Professional soccer statistics are extracted with labor intensive expensive manual effort which is not realistic for amateur matches. In this paper we develop a solution that automatically extracts action-related soccer statistics from a static camera pointed at the pitch. We implement a solution to player localization and action classification problem in human action recognition. Our method does not rely on player tracking, sliding windows, super voxels or construction of multiple hypotheses. Our work is developed with actual application in mind and a fully functional recognition pipeline is implemented, specifically tailored to meet the inherent challenges of action-rich soccer video.


Discourteous behaviours in workplaces may hamper the relations between employees and this may have negative effects on the outputs of employees and enterprises. In this study, the impact of workplace incivility on employee creative performance and the mediating effect of leader-member exchange and the moderator role of age and working time on the relationship between these two were aimed to be put forward. In this context, a questionnaire was conducted with private and public sector employees and managers in Malatya Province to collect data in order to test the moderated-mediation structural equality model formed. The results of the research indicate that workplace incivility adversely affects employee creative performance and leader-member exchange. In addition, leader-member exchange has a mediator role and tenure has a moderator role in the relationship between workplace incivility and employee creative performance.


Congenital abnormalities detected in bovine fetal submissions Nematodirus infection diagnosed with varying clinical presentations in lambs by several centres Lungworm diagnosed as contributing to mixed respiratory disease in outdoor pigs Avibacterium paragallinarum (infectious coryza) infection detected in two flocks Haemonchosis diagnosed in adult alpacas from several farms These are among matters discussed in the Animal Health and Veterinary Laboratories Agency's (AHVLA's) disease surveillance report for April and May


1 This study was designed to examine further the attenuated contractile responses to 5‐hydroxytryptamine (5‐HT) previously observed in aortae from diabetic rats. 2 Cumulative concentration‐response curves to 5‐HT, and the 5‐HT receptor agonists, α‐methyl 5‐HT (α‐Me‐5‐HT, 5‐HT2/1C agonist), (±)‐1‐(2,5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane (DOI, 5‐HT2/1C agonist) and 5‐carboxamidotryptamine (5‐CT, 5‐HT1A/1B/1D agonist), were examined in endothelium‐intact and ‐denuded aortae from 2‐week streptozotocin (STZ)‐diabetic and control rats. 3 In endothelium‐intact and ‐denuded aortae from diabetic rats, maximum responses to 5‐HT and α‐Me‐5‐HT were significantly reduced compared to those of aortae from control rats. Responses to these agonists were inhibited by the 5‐HT2/1C receptor antagonist, ketanserin (0.1 μm). 4 The attenuated responses to 5‐HT of aortae from diabetic rats were normalized by chronic insulin treatment of the rats (5 units day−1, s.c.), but not by altering the glucose concentration of the bathing fluid. 5 The nitric oxide synthase inhibitor N‐nitro‐l‐arginine (NOLA, 0.1 mM) significantly potentiated responses to both 5‐HT and α‐Me‐5‐HT in endothelium‐intact aortae. However, the difference between maximum responses of aortae from diabetic and control rats was still evident in the presence of NOLA. 6 Endothelium‐intact rings, in the presence of ketanserin (0.1 μm) and preconstricted with the thromboxane A2‐mimetic, U46619 (0.1–0.3 μm), from control and diabetic rats, did not relax to cumulative additions of 5‐HT (1 nM‐30 μm). 7 Contractile responses to DOI were obtained only in endothelium‐denuded aortae, and in endothelium‐intact aortae in the presence of NOLA, from control rats. 8 Contractile responses to 5‐CT were obtained only in endothelium‐denuded aortae from both control and diabetic rats, and in endothelium‐intact aortae in the presence of NOLA, from control rats. 9 [3H]‐ketanserin binding studies showed that there was no significant change in the affinity or density of [3H]‐ketanserin for binding sites in membrane preparations of aortae from control and diabetic rats. 10 These results suggest that 5‐HT contracts aortae from rats via 5‐HT2/1C receptor activation. However, the simultaneous release of EDRF from endothelial cells in response to 5‐HT does not appear to be receptor‐mediated. The attenuated contractile responses observed to 5‐HT in aortae from 2‐week diabetic rats do not appear to be mediated by changes in either endothelial cell function or an alteration in 5‐HT receptor affinity or density.


A mass–radius (M–R) relationship is proposed for solid planets and solid cores ranging from 1 to 100 Earth-mass planets. It relies on the assumption that solid spheres are composed of iron and silicates, around which a variable amount of water is added. The M–R law has been set up assuming that the planetary composition is similar to the averaged composition for silicates and iron obtained from the major elements ratio of 94 stars hosting exoplanets. Except on Earth for which a tremendous amount of data is available, the composition of silicate mantles and metallic cores cannot be constrained. Similarly, thermal profiles are poorly known. In this work, the effect of compositional parameters and thermal profiles on radii estimates is quantified. It will be demonstrated that uncertainties related to composition and temperature are secondary compared to the effect of the amount of water. The super-Earth family includes four classes of planets: iron-rich, silicate-rich, water-rich, or with a thick atmosphere. For a given mass, the planetary radius increases significantly from the iron-rich to the atmospheric-rich planet. Even if some overlaps are likely, M–R measurements could be accurate enough to ascertain the discovery of an Earth-like planet. The present work describes how the amount of water can be assessed from M–R measurements. Such an estimate depends on several assumptions including (1) the accuracy of the internal structure model and (2) the accuracy of mass and radius measurements. It is shown that if the mass and the radius are perfectly known, the standard deviation of the amount of water is about 4.5%. This value increases rapidly with the radius uncertainty but does not strongly depend on the mass uncertainty.


The thermal decomposition process of zidovudine( AZT) was studied by means of thermogravimetry( TG),differential scanning calorimetry( DSC),and thermogravimetric analysis coupled with Fourier transform infrared spectroscopy( TGA-FTIR). The infrared spectra of AZT,its gaseous products and remainders from thermal decomposition at various temperatures were determined. The molecular bond orders were calculated by GAMESS method of quantum chemistry,and the mechanism of the thermal decomposition of AZT was discussed. The results indicated that the thermal decomposition of AZT was a three-stage process.Disconnection of the C-N bond between thymine ring and tetrahydrofuran ring occurred in the initial step of the decomposition,and the intermediate was confirmed as thymine.


Echinococcosis or hydatid cyst (HC) is considered one of the major parasitic infections in Libya that causes many health problems and economic losses in communities. The aim of the present study was to determine the prevalence of HC in patients referred to surgery in three hospitals in Benghazi from 2000 – 2007. The study was conducted on 329 patients diagnosed with hydatid cyst disease and treated surgically at the three hospitals. Cystic echinococcosis (CE) affected more females 205 (62.31%) than males 124 (37.69%). Cysts were found in liver and lung in 61.8% and 31.6% of cases, respectively. In addition, cysts were found in brain, muscle, kidney eye, and peritonea in the remaining 6.6% of cases. A significantly higher number of hydatid cysts were recorded in the liver than in other sites (P


Abstract This study aimed to investigate the one-year bond strengths to dentin of one-bottle etch-and-rinse adhesive systems applied under different moisture conditions. Class V cavities were prepared in bovine incisors and randomly allocated (n = 8) according to the type of adhesive system used – SB (Adper™ Single Bond 2); PB (Prime & Bond 2.1); and XPB (XP Bond) – and the moisture condition kept in the cavity – moist, over-wet, and over-dry. Filtek™ Z250 was used for teeth restoration. Specimens for microtensile bond strength (µTBS) test were obtained and stored in water for 24 h or 1 year, and submitted to mechanical testing. Data were analyzed using t-tests, ANOVA and the Holm–Sidak post hoc test (α = 0.05). Weibull analysis was used to verify the reliability of specimens. The type of adhesive and the moisture condition of the substrate affected the µTBS. At 24 h, SB performed better under the moist and over-wet conditions. At 1 year, SB, PB, and XPB showed the greatest percentage reduction at the moist (∼38%), over-wet (100%), and over-dry (100%) conditions, respectively. The reliability of adhesives was affected by the variable factors tested. In conclusion, the solvent composition of adhesives and the moisture condition of the substrate play an important role in the bond strength and bonding stability of resin-based restorations, as well as on the reliability of the adhesive interfaces over time.


PTU-45 Table 1 COVID-19 period (2020) Pre-COVID-19 period (2019) Number of patients 51 51 Female/Male 63%/ 37% 45%/ 55% Mean age (years) 63.4 (21 – 87) 64.8 (29 – 86) ASA grades 1 2 3 4 14% (7) 37% (19) 33% (17) 16% (8) 16% (8) 41% (21) 31% (16) 12% (4) Presenting complain Abdo pain Jaundice 61% (31) 43% (22) 75% (38) 55% (28) Blood test Bilirubin (umol/L) CRP (mg/L) 107 (6 – 493) 66 (1 – 206) 108 (3 – 669) 64 (1 – 342) Indications for ERCP Obstructed CBD Blocked biliary stent Biliary leak 92% (47) 4% (2) 4% (2) 82% (42) 10% (5) 8% (4) Waiting time for ERCP (days) 2.5 (0 – 9) 4.6 (0 – 27) Length of hospital stay (days) COVID-19 +ve COVID-19 -ve 20.6 (8 – 31) 7.1 (1 – 43) 21.5 (0 – 175) 30-day mortality COVID-19 +ve COVID-19 -ve 50% (2/4) 6% (3/47) 8% (4/51) ERCP success rate Cannulation rate Technical failure Complete stone extractions Extrahepatic strictures stented 90% (46) 6% (3) 80% (16/20) 88% (21/24) 86% (44) 16% (8) 94% (16/17) 85% (17/20) ERCP complications Nil Post ERCP pancreatitis Mucosal tear/Bleeding Biliary sepsis Desaturation post sedation 98% (47) 4% (2) - - - 88% (45) 10% (5) 2% (1) 2% (1) 2% (1) In the COVID-19 positive cohort, two patients passed away due to worsening COVID pneumonitis. One of the patients had COVID-19 prior to ERCP, while the other contracted COVID-19 post-ERCP. Patients who were negative for COVID-19 passed away due to metastatic adenocarcinoma of bile duct, bilateral pleural effusions and atelectasis post cholecystectomy and pulmonary embolism.In comparison to 2020, the mean length of hospital stays and waiting time for ERCP were slightly longer, at 21.5 days (range, 0-175) and 4.6 days (range, 0-27) respectively.ConclusionPatients undergoing ERCP who were infected with COVID-19 had longer hospital stay, and higher 30-day mortality compared to those who did not have COVID-19. However, length of hospital stay was shorter in COVID time. There was no statistically significance in the KPI between COVID-time and normal times.


The internet opens up new horizons for (science) communication: through classical websites, weblogs, wikis, podcasts, or videos. Specific research on the potential these communication media offer for university museums and collections is still missing. Therefore, the paper presents and surveys the current use of internet communication in order to provide fundamental material for critical discussion. The study is based on collections registered in the online database "University Museums and Collections in Germany".


I must confess at the outset that despite repeated reading and study I am not quite sure what Dan Raff is driving at in this paper. In the end, I have decided he is telling us to write good history. He is suggesting that we not simply work backward from a known outcome and assemble a coherent explanation of how the firm arrived at that point. Rather, we should put ourselves into the flow of events as they happened. We should consider the complexity and uncertainty of change as it occurred. We should identify paths considered but not taken (or maybe not considered at all), dead ends pursued, obstacles encountered and interim solutions devised, course readjustments midstream—in sum, the full array of choices made by those who attempted to steer the firm toward some destination, be it the eventual end point we observe or some other unfulfilled alternative. And of course we should keep in mind that our historical actors did not see our end point as The End; they were necessarily thinking beyond that outcome or at least were being swept onward by the course of events. In my favorite of his many aphorisms, Raff cautions us that "the reasons survivors look strong now are not necessarily the reasons they survived the crises then." The point resonates with much of what I have to say here. Raff's call begs two obvious questions. First, why should we do this? What ends does such history serve? Second, how do we put this prescription into practice? These questions sound distinct but ultimately cannot be. Our aims cannot be separated from our means. This becomes clear, I think, when we turn from theory to actual examples. Now, by his own admission, Raff's paper is a tad thin on examples. I recall one brief allusion to General Motors (GM). I suppose I was


The lifetime of wireless sensor networks deployments depends strongly on the nodes battery state of health (SoH). It is important to detect promptly those motes whose batteries are affected and degraded by ageing, environmental conditions, failures, etc. There are several parameters that can provide significant information of the battery SoH, such as the number of charge/discharge cycles, the internal resistance, voltage, drained current, temperature, etc. The combination of these parameters can be used to generate analytical models capable of predicting the battery SoH. The generation of these models needs a previous process to collect dense data traces with sampled values of the battery parameters during a large number of discharge cycles under different operating conditions. The collected data allow the development of mathematical models that can predict the battery SoH. These models are required to be simple because they must be executed in motes with low computational capabilities. The paper shows the complete process of acquiring the training data, the models generation and its experimental validation using rechargeable batteries connected to Telosb motes. The obtained results provide significant insight of the battery SoH at different temperatures and charge/discharge cycles.


Calcium level is maintained by parathyroid hormone, 1alpha, 25 (OH)(2)D(3) and calcitonin in cooperation with bone, kidney and intestine. In the kidney activation of vitamin D and transcellular calcium transport in distal tubule regulate calcium concentlation. In the parathyroid glands calcium-sensing receptor sense extracellular calcium and secretes parathyroid hormone. It is received negative feedback from 1alpha, 25 (OH)(2)D(3) and phosphate.


By means of Jones vector, we obtain the Jones vector of superposed two partially polarized light, and, with the degree of polarization, we have analyzed poincare sphere representation of superposed partially polarized light.


With the rapid development of component technology,it has become an effective method to enhance productivity and quality of software.Component testing is one of the most important techniques used to assure the quality of software compo- nent.The Component testing platform(CTP)is an operational platform to increase testing efficiency and decrease testing costs. This article introduces the conception,architecture and implementation technology(Web Services)of Service-oriented architec- ture(SOA).Then,how to build the framework of CTP witlh SOA is proposed.Finally,the advantage of CTP is given.


Slow Ca‐action potentials (CaAP) were studied in normal human skeletal muscle fibers obtained during surgery (fibers with both ends cut). Control studies also were carried out with intact as well as cut rat skeletal muscle fibers. Experiments were performed in hypertonic Cl‐free saline with 10 or 84 mM Ca and K‐channel blockers; muscles were preincubated in a saline containing Cs and tetraethylammonium. A current‐clamp technique with two intracellular microelectrodes was used. In human muscle, 14.5% of the fibers showed fully developed CaAPs, 21% displayed nonregenerative Ca responses, and 64.5% showed only passive responses; CaAPs were never observed in 10 mM Ca. In rat muscle, nearly 90% of the fibers showed CaAPs, which were not affected by the cut‐end condition. Human and rat muscle fibers had similar membrane potential and conductance in the resting state. In human muscle (22–32± C, 84 mM Ca), the threshold and peak potential during a CaAP were + 26 ± 6 mV and + 70 ± 3 mV, respectively, and the duration measured at threshold level was 1.7 ± 0.5 sec. In rat muscle, the duration was four times longer During a CaAP, membrane conductance was assumed to be a leak conductance in parallel with a Ca and a K conductance. In human muscle (22–32° C, 84 mM Ca, 40 μS, fiber diameter), values were 0.4 ± 0.1 μS, 1.1 ± 0.7 μS, and 0.9 ± 0.4 μS, respectively. Rat muscle (22–24° C, 84 mM Ca) showed leak and K conductances similar to those found in human fibers. Ca‐conductance in rat muscle was double the values obtained in human muscle fibers.


Abstract : The Union's Atlantic blockade campaign of the South during the first year of the American Civil War is analyzed in the general context of operational art and with a view to lessons learned. The joint operations of Union forces are described at the operational level. Tactical descriptions of the first two engagements are detailed only as necessary to understand operational movement. Flag Officer Silas Stringham and Major General Benjamin Butler led a joint expedition to gain Federal access to the North Carolina interior waterways. Flag Officer Samuel du Pont and Brigadier General Thomas Sherman led a second expedition to establish an ideal base of operations at Port Royal, South Carolina. The combination of overwhelming force and sound tactics at key decisive points led to important Union victories that opened the door to effective follow-on operations. The campaign as a whole significantly tightened the Union blockade of the South, and helped to establish the economic, political, and military context for ultimate Union victory in the Civil War. (KAR) P. 1


We study the steady state in three-level lambda (\ensuremath{\Lambda}) and ladder systems. It is well known that in a \ensuremath{\Lambda} system this steady state is the coherent population trapping state, independent of the presence of spontaneous emission. In contrast, the steady state in a ladder system is in general not stable against radiative decay and exhibits a minimum in the population of the ground state. We show that incoherent population pumping destroys the stability of the coherent population trapping state in the \ensuremath{\Lambda} system and suppresses a previously discovered sharp dip in the steady-state response. In the ladder system the observed minimum disappears in the presence of an incoherent pump on the upper transition.


Acute myeloid leukaemia (AML) is a heterogeneous disease characterised by an abnormal increase in myeloblasts. Current treatment protocol employs the standard "7+3" chemotherapy regimen complemented with haematopoietic stem cell transplantation. However overall cure rate remains at 30-40%. Targeted therapy, especially the use of tyrosine kinase inhibitors, has been the main focus in the pursuit of an alternative solution. Internal tandem duplication at the juxatmembrane domain of fms-like tyrosine kinase 3 (FLT3-ITD) was found in around 30% of AML cases, conferring unfavourable treatment outcome and prognosis. Sorafenib, and other FLT3 inhibitors, successfully induced remission or partial remission in most of the relapsed/refractory FLT3-ITD AML patients (CR/CRi/nCR = 82.4%, n=34 in our sorafenib monotherapy cohort). Although consolidation with combination of sorafenib and chemotherapy or hypomethylating agents was reported to significantly extend the remission period, all patients relapsed with drug resistance. Mutations at the tyrosine kinase domain (TKD) were reported to alter the binding affinity of the drugs to the receptor and hence generate resistance. However, they were found only in around 25% of the patients while other non-mutational mechanisms of resistance have also been reported. Their relative importance in patients remains uncertain. We hypothesised that there is an emergence of drug-resistant clones acquiring new mutations or pathways to develop the resistance. We have performed whole exome sequencing (HiSeq pair-end sequencing of 101 bp) for sorafenib-sensitive and sorafenib-resistant samples obtained from 8 FLT3-ITD relapsed/refractory AML patients before sorafenib treatment and at relapse with drug resistance. Genomic content of the bulk population was observed to change drastically among the 8 patients, with disappearance of single nucleotide polymorphisms (SNPs) and emergence of new SNPs, suggesting the emergence of drug-resistant clones. Emergence of TKD D835Y mutation was observed in 3 patients with variant allele frequencies (VAF) at 11%, 44% and 50% that were undetectable in the sorafenib-sensitive samples. Mutations at other reported sites of TKD were not found. Filtering of the generated list of single nucleotide changes and insertion/deletions (indels) to sort out emerging non-synonymous mutations with high VAF at resistant samples but undetectable in the sensitive samples was done. They include SLC15A1, CDC27, NADKD1, DGAT2, UBXN11, TFR2 and TTBK1, potentially implicated in sorafenib resistance. They are involved in different pathways, including membrane transporter, cell cycle regulation and energy metabolism. Further functional validation of their role in sorafenib resistance is required to understand the mechanisms involved. Disclosures No relevant conflicts of interest to declare.


All nurses should receive three days of fully funded continuing professional development every year, RCN president Sylvia Denton told college members at the opening of their annual congress (pictured) this week.


In the second part of this two-part paper, the mathematical model of U-core permanent magnet machines is derived and used to determine the steady state performance of a prototype machine. Based on this model, the current and torque are calculated as function of time, allowing the design and optimization of this kind of machine to be undertaken. The theoretical curves are compared with measured ones, obtained with a prototype machine built and tested.


possibility that the UK was under two equal but opposite obligations, and thus to step into the realm of policy-making by making a choice between the two. Attempts to force a resolution of the norm conflict—by using the test derived from B to establish a quasihierarchy of norms, with 'general' international law norms superior to those of the ECHR—were both unconvincing and, ultimately, futile. The UK has been 'outed' in having to make a choice between one obligation and the other, between expediency and principle.


In fact,most of the mining area of the bottom of the well established single-channel operation in order to take into the car and out the coal,and used the bottom of the well to adopt vehicle scheduling.This article solves the transportation of themining vehicles in such environment by using PV operation.


Two new species of Catostomus (sensu stricto) are described from northwest Mexico. One inhabits northeastern headwater streams in the Rio Yaqui drainage and the other is widely distributed in the southern and southeastern parts of the Rio Yaqui and in the upper Rio Mayo basin. These new taxa exhibit low pharyngeal tooth counts, possibly indicating a close relationship between them. They are hypothesized to be members of an old, regional ichthyofauna that stretches from central Mexico to northwest United States.


Since 2004, Cassini's Composite Infra-Red Spectrometer (CIRS) has taken over a million spectra of Saturn's main rings. Almost all spectra are well fit with a Planck function and scalar multiplier, producing a database of effective temperature and emissivity that vary with location, illumination and viewing geometry. Use of this data to extract information about the rings has been complicated by the many parameters influencing the emission, and by computational difficulties. Here we present a new method for addressing two of the basic computational hurdles in producing verifiable models of Saturn's ring emission.


The use of caribou (Rangifer tarandus) and beaver (Castor canadensis) by New England Paleoindians has been confirmed by new evidence. Using an approach which includes consideration of bone shrinkage during calcination, in addition to species—specific morphology, Spiess has identified faunal assemblages composed exclusively of mammal bone from two sites in central New England, The Bull Brook site (Massachusetts) and the Whipple site (New Hampshire). Caribou is the most commonly identified species at both sites, although beaver is present at Bull Brook. Because of the variability of caribou behavior in different environmental contexts, the implications of these identifications for the reconstruction of Paleoindian subsistence economy must await further research.


PURPOSE: A city sculpture management server and a system thereof are provided to implement independent and integrated control of sculptures by independent operation even if a management server is out of control. CONSTITUTION: A schedule event queue(21) registers a schedule and an event which are read from a schedule database(30). A pre-scheduler(23) checks one or more schedules which are in the front of the schedule event queue. A schedule synchronization unit(43) synchronizes a schedule stored in the schedule database and a schedule stored in an agent. A control unit(60) transmits a control command to the agent at the operation time of each sculpture and sculpture composition equipment. [Reference numerals] (10) Schedule register; (20) Scheduler; (21) Schedule event queue; (23) Pre-scheduler; (30) Schedule database; (40) Synchronization unit; (41) Time synchronization unit; (43) Schedule synchronization unit; (50) Communication unit; (60) Control unit;


The purpose of this study is to determine the variables associated to the development of Burnout on Arica's municipal educational establishment workers. Analyzing the results according to the Burnout statement and diagnose. A non-probabilistic sampling was used because of the availability, this way the sample was contituted with 120 people (71.7% women and 28.3% men; a 30.8 % presented Burnout, a 40% evidenced risk of experiencing it, and 29.2% did not present signs of it). Regression models allow us to explain punctuation for the three Burnout dimensions (according to statement and diagnose) from the variables of the organizational, group, or personal order. Finally, the variables which fall into the development of the Burnout Syndrome on the sample used are established.


In this paper, We propose a novel power allocation scheme for physical-layer network coding (PNC) in uplink multi-way relay channels (MWRC). The power allocation is formulated as a constrained optimization problem under the transmitting power constraint of user terminals, aiming at maximizing the success probability of the successive interference cancellation (SIC) detection at the relay. optimizing over such a metric maximizes the probability of correctly detecting all user signals, which is critical to the network code generation at the relay. Specifically, We first develop a generalized closed-form success probability of the SIC detection on signals with pulse-amplitude modulation (PAM) at the relay. A constraint optimization is formulated over this probability subject to the poWer constraints of user terminals. We implement an evolutionary particle swarm optimization (PSO) algorithm to solve the problem whose cost function is complicated and not necessarily concave. The numerical results show that the proposed power allocation method can improve the quality of network code extraction at the relay.