The energy longevity of mobile devices, especially those which support multimedia, is becoming more important. In this dissertation, two methods are introduced to reduce the energy consumption of mobile video devices, because energy efficiency is critical in prolonging battery life. Also, network bandwidths of these mobile devices vary and are not always guaranteed. First, the work in this dissertation analyzes various lookup table techniques used for variable length coding in video codecs such as H.264/AVC to determine which one is most suitable in a low power environment and which power component should be minimized. The results presented show that a tree lookup table structure is an excellent choice to reduce power consumption that would help prolong battery life of the mobile decoding device. Also, scalability is a major issue for future video systems and their network adaptability and compatibility with legacy devices. Thus, this dissertation also presents a bit-depth scalable video algorithm that can be used to provide both the support for future high bit depth colors as well as reducing mobile power consumption via bandwidth reduction.


Abstract In this paper measured saturated electron drift velocity is 3.8cm/μs using an uniform field drift chamber and saturated effect of gas multiplication is occured above the 2×104 amplification factor in He/C3H8(60/40) gas mixture are reported. On the lower edge of energy spectrum of 55Fe 5.9 keV KX ray the total energy photoelectron peak from 1.5 keV Al characteristic KX ray in Helium is observed due to the decrease of the perturbation from amplifier noise .


Known as one of the leading companies involved in building integrated Photovoltaic (PV) systems, Atlantis has fabricated, designed and installed a large number of impressive PV systems all over the world. In addition to the two existing manufacturing facilities in Europe (Harkingen (CH) and Gera (D)) a new Atlantis manufacturing facility was built in the United States in 1995 to supply the American market with solar electricity generating building materials. The facility is located in Exmore, VA near the Chesapeake Bay. To successfully enter the American PV market, the products had to pass hardest test conditions of Underwriters Laboratories (UL) and PVUSA. For selling Photovoltaic roofs, the different ways and codes of building houses in the USA compared to Europe have to be taken into account.


The purpose of this white paper is to inform individuals and companies that they may be subject to complex federal patient privacy regimes. Federal laws regarding patient privacy have expanded greatly over the past two decades and the nature of enforcement for patient privacy violations has changed with them. These changes have resulted in an increased level of enforcement, and in significantly larger fines being imposed upon violators by the government agencies tasked with enforcement. Additionally, recent changes in the interpretation of these federal statutes have arguably increased the efficacy of private civil suits dramatically - by utilizing HIPAA as the standard for determining the duty of care owed to patients in negligence cases. The result of these converging factors is that a large number of the entities covered by federal statutes relating to patient privacy are unaware that they are subject to that legal regime. Simultaneously, all entities covered by these federal statutes are faced with an ever more stringent standard of compliance, and even larger civil and criminal penalties in the event of non-compliance. In addition to informing the reader about the expansion of federal patient privacy law and its impact upon businesses entities and attorneys, this paper proposes that one possible solution for entities presently affected by federal patient privacy legislation would be to utilize outsourced compliance solutions. These services would provide covered entities with the ability to maintain the ongoing compliance required by federal law, while potentially reducing the frequently dramatic increases in costs associated with compliance. This paper will first discuss the evolution of patient privacy rights in the United States. It will then discuss the modern patient privacy right framework under federal law - including the scope of the statutes, the evolution of enforcement of patient privacy rights, and how recent changes have made compliance essential for any affected entity. Finally, it will end by highlighting the benefits generally associated with outsourcing and discuss how they might be applied by entities affected by federal patient privacy statutes.


New microelectronic fabrication techniques enable the creation of high-performance on-chip antennas by using new or modified antenna designs. A system's performance is normally improved by a high antenna gain which requires an electrically large aperture typically supporting an array. Consequently, array design is of particular interest for high-performance on-chip systems. The feed for an array is a challenge because it must be low loss while extending over the large aperture. A solution is the waveguide slot array which integrates antenna elements with a low-loss feeding structure. This study presents a new slot array structure which is motivated by advanced microelectronic fabrication. It comprises a triangular waveguide as the array feed, and slots for the elements. This allows fabrication by a self-assembly technique which lithographically controls the shape of a three-dimensional structure. This process is complementary metal–oxide–semiconductor compatible, enabling radio and radar system-on-chip solutions. For production, the low mass of the structure makes it inherently robust, although hermetic packaging with a radio window akin to UV-erasable eproms would be required (not included here). The design concept is demonstrated with a physical prototype operating at a low frequency. The fabrication concept is demonstrated by a physical on-chip prototype, and its performance is assessed by simulation.


Abstract (±)-Raikovenal (1a) has been synthesized in five steps from dihydrofilifolone (3) by two Wittig reactions. A similar sequence provides (±)-preraikovenal from aldehyde 11. Epiraikovenal (1b) has been prepared by photolysis of preraikovenal or by photolysis of 5 to give 4b. Lewis acid induced cyclization of enal 5 gives cyclopentylideneacetaldehyde 16 rather than bicyclo[3.2.0]heptanecarboxaldehyde 4.


A variety of scaffolds, including collagen-based membranes, fleeces and gels are seeded with osteoblasts and applied for the regeneration of bone defects. However, different materials yield different outcomes, despite the fact that they are generated from the same matrix protein, i.e. type I collagen. Recently we showed that in fibroblasts MMP-3 is induced upon attachment to matrix proteins in the presence of TGFbeta. Aim: To investigate the regulation of matrix metalloproteinases (MMPs) and interleukins (IL) in osteoblasts upon attachment to type I collagen (col-1) in comparison to laminin -1 (LM-111) in the presence or absence of costimulatory signals provided by transforming growth factor beta (TGFbeta). Methods: Osteoblasts were seeded in col-1–and LM-111-coated flasks and activated by the addition of TGFbeta. Mock-treated cells served as controls. The expression of genes was investigated by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), immunocytochemistry and ELISA. Results: Attachment of osteoblasts to col-1 or LM-111 failed to activate the expression of MMPs or ILs. In contrast, TGFbeta induced the expression of MMP-3, MMP-9, and MMP-13, IL-6 and IL-16 mRNAs. MMP-3 was found to be elevated in supernatants of activated cells. No difference was found in the expression of MMP-1, IL-8 and IL–18. Interestingly, the expression of IL-1beta mRNA was not activated by TGFbeta alone, but it was activated by attachment of osteoblasts to LM-111 in the presence of TGFbeta. Conclusion: In contrast to fibroblasts, attachment of osteoblasts to col-1 or LM-111 had no effect on the induction of MMPs and ILs. TGFbeta induced the expression of MMPs and ILs in these cells but only MMP-3 was released. The results show significant differences between osteoblasts and fibroblasts in the effects of attachment to scaffold materials. This may have important consequences for tissue engineering of bone and for wound healing after surgery.


The paper considers the methods to improve the efficiency of the business process of repairing powergenerating equipment, as one of the main directions for increasing the efficiency and safety of the company activity as a whole. The efficiency of power generating companies is currently determined by the quality of the fieldoriented and supporting business processes arrangement. Companies in the power-generating sector have strict environmental and energy security requirements. Accidents at production and transport facilities can cause irreparable environmental deprivations. Also, the failure of the mains sections can completely stymie the work of large settlements, and endanger the life and health of people in the cold season. The performance of the equipment can be impaired as a result of natural causes (corrosive wear, metal fatigue, and other deformations) and due to violation of the operating mode. The good condition of the processing equipment is ensured by the maintenance and repair works performed in time. Company's experience has proven that, for the safe operation of processing equipment, it is necessary to annually appropriate funds in the amount of at least 2% of the initial cost of the equipment. The main focus should be on planning and arranging the processes involved. Safe operation can also mean availability to purchase equipment necessary for production tasks. Many large power generating companies are trying to act under the principle of technological self-sufficiency. It implies the presence of technological developments in intellectual property, as well as production facilities. The implementation of this principle is possible both through the development of own scientific resources, and through the absorption of industrial enterprises. All this gives a competitive advantage to power generating companies, as well as expands the range of services provided.


In Africa, rabies is maintained in populations of owned, free-roaming domestic dogs, but can be controlled by mass vaccination. It has previously been reported that rabies in dogs can be controlled if at least 40 per cent of a population is immune at any one time. To maintain this threshold, the World Health Organization (WHO) recommends that mass dog vaccination campaigns should achieve a vaccination coverage of at least 70 per cent of the population in a given area. However, the proportion of immune individuals may decline between vaccination campaigns as vaccinated dogs die and susceptible dogs enter the population through birth or migration. This study aimed to measure the rates of birth, death and migration in a population of free-roaming dogs in South Africa and assess the implications of mass rabies vaccination in the population. An initial census of an owned dog population in a community in Mpumalanga Province, South Africa was conducted from July to October 2011. The census was combined with a house-to-house rabies vaccination campaign. Following the census, repeated visits at regular intervals over a 24-month period to all households within the study community were undertaken. Demographic events, that is, births, deaths and migrations into and out of households, were recorded. To assess whether a 70 per cent vaccination coverage was sufficient to maintain population immunity above the 40 per cent threshold for a 12-month period, 70 per cent of dogs were randomly assigned a positive vaccination status during two simulated campaigns. The number of vaccinated dogs still present in the population 12 months later was divided by the total number of dogs in the population to give the vaccination coverage. During the study period, the annual population growth rate in 2012 was 18.6 per cent, while in 2013 it declined by 24.5 per cent. The results of the vaccination simulation showed that, despite the growth of the population during 2012, coverage remained around the 40 per cent threshold for that year. The decline in population in 2013 slowed the rate of decreasing vaccination coverage from the 2012 campaign. The second campaign in 2013 kept the coverage well above the threshold for that year. The authors found that, to ensure immunity in 40 per cent of the population 12 months after vaccination, the minimum vaccination coverage for the campaigns was 61 per cent in 2012 and 52 per cent in 2013. The authors conclude that their findings support the WHO's target of 70 per cent vaccination coverage during annual campaigns, and that it is possible to achieve this even in highly dynamic populations with high growth rates and rapid turnover.


We model demand for di¤erent classes of antibiotics used for respiratory infections in outpatient care using a linear approximate almost ideal demand system approach. We compute elasticities to socioeconomic determinants of consumption and own- and cross- price elasticities between di¤erent groups of antibiotics. We .nd signi.cant elasticities between newer/more expensive generations and older/less expensive generations of antibiotics. The larger use of more expensive antibiotics is also associated with the self-dispensing status of practices, ceteris paribus.


Introduction

Expression Vectors

Transcription

Translation

Cellular Compartments

Cytoplasm

Periplasm

Membranes and Cell Surface

Extracellular Medium

Protein Stability

Protein Folding

Fusion Proteins

Summary

Bibliography

Keywords:

chaperone;
E. coli;
fusion protein;
gene expression;
vector


A method for determining a location and a direction for viewing a protrusion comprising the steps of: Directing a plurality of beams in an outward direction from a point where the point is located within a protrusion; Selecting at least one of the plurality of beams for determining a location and a direction for viewing the protrusion; and Determining a location and a direction for viewing the protrusion using the selected at least one of the plurality of beams.


According to regulation of construction project completion check and acceptance for environmental protection and working practice,some technical issues in cement industry were analyzed such as monitoring condition control,wastewater monitoring,flue gas monitoring,noise monitoring and environment quality monitoring.It made suggestion that environmental protection check needed to focus on implementation of environmental protection laws and regulations system,pollution prevention facilities,enterprise environment management,wastewater outlet standardization,health protection distance,total amount pollutants control,elimination of obsolete industrial equipment as well as public participation.


The shallow protections,water and soil conservation and ecological functions of slope vegetation were introduced.Taking the vegetation slope protection work in rock slope of water transport tunnel in Yanshan Reservoir as an example,the paper analysed the general situations of rock slope,and comprehensively compared the effect of vegetation concrete ecological protection,anti-scour base material ecological slope protection and soil spray-sowing technology,then put forward three technological and construction measures in winter.The practice indicates that vegetation slope protection works have good comprehensive effects on slope protection,water and soil conservation.


Method for obtaining a 3D image using a CCD sensor is proposed. A prototype that implements the proposed method is developed. Received and processed data using a prototype. Using the prototype, experimental data on the distance to the test objects were obtained. Based on the data obtained, a depth map was built. The accuracy of the built depth map is 5 сm.


We investigate near-field infrared spectroscopy and superfluid polariton imaging experiments on conventional and unconventional superconductors. Our modeling shows that near-field spectroscopy can measure the magnitude of the superconducting energy gap in Bardeen-Cooper-Schrieffer-like superconductors with nanoscale spatial resolution. We demonstrate how the same technique can measure the c -axis plasma frequency, and thus the c -axis superfluid density, of layered unconventional superconductors with a similar spatial resolution. Our modeling also shows that near-field techniques can image superfluid surface mode interference patterns near physical and electronic boundaries. We describe how these images can be used to extract the collective mode dispersion of anisotropic superconductors with sub-diffractional spatial resolution.


The cultivation of creative talents is not only the ultimate pursuit of universities,but also the demand and expectation of society on universities.In the process of cultivating creative talents,universities should first transform the way of thinking of students,and construct a faculty which has the idea of creative education,then reasonably adjust the setting of course,and then build a harmonious and free campus environment to provide a scientific and effective innovation environment for the cultivation of creative talents.


Purpose: To investigate new diagnostic criteria of keratoconus using Orbscan II Slit Scanning Corneal Topography/Pachymetry System. Methods: Eighty eyes of 45 patients with keratoconus and 100 randomly selected eyes of 50 patients without any ophthalmologic problem were enrolled in this study. Anterior elevation from BFS, posterior elevation from BFS, Sim K (maximum), and thinnest pachymetric value were evaluated using Orbscan II. Values outside 2 standard deviations from the mean value of each parameter were estimated to the upper or lower limits in diagnosing keratoconus. Results: There were significant differences of all parameters of Orbscan II between the keratoconic eyes and the control (p 23.3 m, posterior elevation from BFS > 49.8 m, Sim K (maximum) > 47.0 D, thinnest pachymetric value m. Conclusions: Orbscan II can provide useful information in the diagnosis of keratoconus with high sensitivity and specificity.


We have measured both the static and dynamic structure factors of a single dendrimer with small-angle x-ray scattering (SAXS) and neutron spin-echo spectroscopy under good solvent conditions with the aim of finding a consistent correlation between the structural properties of dendrimers and their dynamic behavior. The samples under investigation were star-burst polyamidoamine dendrimers with generations g=0 to 8 in dilute methanol solutions. A model independent approach employing inverse Fourier transformation and square root deconvolution methods has been used to analyze the SAXS data to obtain the pair distance distribution function p(r) and the radial excess electron density profile Δρ(r). In addition, we formulated a model that takes both the colloidal (globular, compact shape with form polydispersity or fuzzy surface) as well as the loose, polymeric (self-avoiding random walk) character of dendrimers into account. With this model we were able to describe the spectra of all dendrimer generations consi...


My earliest memories of O.L. are hearing his name as part of an introductory phrase as in, "O.L. says...." or "According to O.L...." as if he were some sort of Zeus-like figure off at the "mother" school, the University of Texas at Austin. In 1983, at UT Northwest, also known as Eastern New Mexico University (ENMU), four of O.L.'s advisees were on the faculty; George Mehaffy who was my master's committee chair, Mark Isham, also on my master's committee and still at Eastern, Charles Jackson, and, during the summers, Milam Rowald. O.L.'s name frequently arose in conversations, especially those related to Mark's finishing his dissertation. Little did I realize in 1982-83 that I, too, would begin my sentences with "Dr. Davis says...." Ten years later I, too, would say, "O.L. says...." I recall the circumstances of my first meeting with O.L. quite vividly. When Sherry Scarborough graduated in 1983, George Mehaffy tapped me to be the president of the Omicron Upsilon, the ENMU chapter of Kappa Delta Pi (KDP). In 1984, the KDP Convocation was being held in Montreal, Canada, in April. George said I had to go as the chapter representative, not that the chapter could afford to pay my way, but the chapter "had" to be represented and, it would give me an opportunity to meet Professor O.L. Davis, Jr. and see, as I recall, if I would pass muster and be an acceptable potential doctoral student at UT studying under O.L. Doctoral studies had not been/were not in our family 5-year plan--Bonnie and I had recently married in 1983 and were planning on returning to Amarillo, where she owned a house, upon my graduation in 1984. But, at the urging of George and Mark, we flew to Montreal--one of the worst experiences of our married life, but a story for another time--to attend the KDP Convocation and meet the "man." During a break in the business and legislative sessions, Convocation ran from Wednesday evening until Sunday back then, George came and said, "Come, Lynn, it is time to go and meet O.L." Dutifully, I checked my shirt and coat for crumbs and flakes, straightened my tie and followed George--still Dr. Mehaffy at that time--down under the Queen Elizabeth Hotel to the lower city and a small glass-walled coffee shop where this man sat a table. I was in the presence of O.L. Davis, Jr.. I don't remember what happened next or what we talked about but after a short time George and I left O.L. sitting there talking to others who stopped in because they saw him sitting there in the shop. George told me after we left that I had done well and that things were going to be okay. Several weeks later, after our return to Portales from Montreal, George called me into his office to let me know that O.L. had obtained a fellowship for me and I was approved to start the doctoral program in August. As I previously stated, going on for a doctorate was not part of the new Burlbaw family plan and several weeks of discussion ensued before I/we decided we were going to Austin, but only long enough for me to get my degree, and then we would be back off to Amarillo or New Mexico or Arizona where we had family. Little did we know! So, what was it about this "O.L. guy" that so impressed George Mehaffy and Mark Isham that I had to go to first to Montreal to meet and then to Austin to study with him? As I recall George saying, not just once, but many times, "O.L. has more ideas in one day than most people have in a life-time." I have no doubt that part of the Montreal conversation consisted of O.L. running some "ideas" by me and me making some sort of, obviously appropriate, responses. The condition of having ideas has, for me, been one of the defining characteristics of my relationship with O.L. and his willingness to share those ideas and to encourage me to have ideas and seek ideas from other. "Have you thought of ..." or "What would it be like if ..." or "How do you suppose ..." appear in every conversation with O.L., even if the intended purpose of your conversation was to find out when you were going to get the draft of chapter III of your dissertation back! …


The paper investigates the exhibition activities of artists, aimed at the development of the Soviet professional fine art. Revealed variety of genres and the main content of the work of artists. The role of the media in promoting the creation of the Ural painters and distributed their aesthetic values.


At the annual meeting of the Southern Seismic Well Shooting Association held in Shreveport on April 4, a motion was passed recommending to SEG that the Society take steps toward formulation of a recommended standard form for the acoustic (continuous‐velocity or sonic) log.


Large companies have different methods of doing this, one of which is to run sales simulations. Such simulation systems often need to perform complex calculations over large amounts of data, which in turn requires efficient models and algorithms. This chapter intends to evaluate whether it is possible to optimize and extend an existing sales system called PCT, which is currently suffering from unacceptably high running times in its simulation process. This is done through analysis of the current implementation, followed by optimization of its models and development of efficient algorithms. The performances of these optimized and extended models are compared to the existing one in order to evaluate their improvement. The conclusion of this chapter is that the simulation process in PCT can indeed be optimized and extended. The optimized models serve as a proof of concept, which shows that results identical to the original system's can be calculated within < 1% of the original running time for the largest customers.


Objective To investigate the expression of glucose transporter1(GLUT1),multidrug resistance related protein(MRP) and glutathione S-transferase pi(GST-π)in lung cancer.Methods The expression of GLUT1,MRP and GST-π were tested by immunohistochemical method in 42 cases of lung cancer specimens including 28 males and 14 females,with an average age of 54.7.Among them 2 cases were small cell cancer,21 cases squamous cancer,16 cases adenocarcinoma,and 3 cases bronchiolo-alveolar carcinoma.Results In 42 cases of lung cancer specimens,36 cases showed positive staining of GLUT1 protein(85.7%);24 cases showed positive staining of MRP protein(57.1%);23 cases showed positive in GST-π protein(54.8%).There was a significant positive correlation between the expression of GLUT1 and GST-π(P0.05),but there was no significant correlation between GLUT1 and MRP(P0.05).As compared with the expression of GLUT1,MRP and GST-πin lung cancer tissues of T1 and T2 group,there was significantly increased the T3 and T4 group(P0.05,P0.025,P0.01 respectively).The expression of GLUT1,MRP and GST-πwith lymphatic metastasis in lung cancerwas significantly higher than those without lymphatic metastasis(P0.05,P0.05,P0.025 respectively).Conclusion High expression of GLUT1 at lung cancer tissue could be seen in human lung cancer,and there was significant positivecorrelation between the expression of GLUT1 and GST-π.GLUT1 might up-regulate the expression of GST-π.High level expression of GLUT1,MRP and GST-π is related with the invasion degree and lymphatic metastasis of lung carcinoma.


. The proteases secreted by four strains (MT004, 1102, 480 and 480P-) of Aeromonas salmonicida grown in liquid culture have been studied. Strains MT004, 1102 and 480 all show a similar pattern with two types of proteases produced; one of molecular weight 70 000 which is active against casein and gelatin and one (or more) of lower molecular weight (about 20 000) which is (are) active against gelatin but not casein. Strain 480P- produces only the latter type of protease(s). The protease of molecular weight 70 000 is classified as a serine-type protease, but further characterization of the features of its active site has not yet proved possible. The results are discussed in terms of the previously published but often contradictory data on the proteases of A. salmonicida.


Sabbath, Community, and a New Imagination: Learning to Listen in Treynor, Iowa Adam Magill Doctor of Ministry School of Theology, Fuller Theological Seminary 2018 In a world filled with idols vying for people's allegiance, communities can easily lose their capacity to listen to and care for each other. The purpose of this project is to explore the various forces attempting to dominate life in Treynor, Iowa, in order to help neighbors to examine their own priorities and discover together a new imagination of Sabbath life and practices. Utilizing the frameworks of Appreciative Inquiry and the Missional Change Process, a small group of leaders from Zion Congregational Church led two-session interviews with their neighbors. These interviews asked questions about faith and life in the Treynor community and explored the relationship between neighbors and the potential idols of work, sports, and consumerism. These interviews found that when neighbors spent time listening to other neighbors, their captivity to life-stealing forces lessened as they become more aware of the competing claims for their allegiance and instead began dreaming about Sabbath life and practices together. This project humbly attempts to remind the larger church that there is life beyond the supermarket of idols in which we find ourselves; an alternate imagination of life can be awakened, one that is rooted in Sabbath practices flowing out of a primary relationship with God. May God lead us all in discovering this new imagination, as neighbors listen to each other and challenge the status quo. Content Reader: Alan Roxburgh, PhD Words: 223 "Learn something!" -Tom Magill To my beautiful wife and children: Thank you for your love and support through this season of life. I am looking forward to our next adventures together.


In this paper, we propose a database selection method for cherry blossom movie databases constructed on the assumption that large amounts of movie data on different observation locations are constantly stored into the corresponding areas of the movie database. Our proposed method extracts a suitable candidate set of movie databases according to the user's image query based on the color information that summarizes the characteristics of each movie database in the distributed movie database environment. Our method focuses on the color frequency trend of cherry blossoms in a movie database to extract the movie databases that include flowering states in the image frames similar to the user's input cherry blossom image and to extract the period by analyzing the increasing and decreasing trend of the specified flower color within the specified period. In the experiment, we evaluate the feasibility of our proposed method in the distributed movie database environment, where each movie database consists of pseudo-movie data on cherry blossoms.


We evaluate the dielectric reliability performance of 21 nm pitch interconnects integrated in a dense low-k and using a barrierless Ru fill scheme. We show our line-to-line and tip-to-tip TDDB pass 10 years of lifetime at 0.75 V for technology relevant line lengths and number of tips, respectively. Intrinsic dielectric breakdown without metal drift is demonstrated using BTS-TVS measurements. We also investigate the impact of dielectric scaling towards lower dimensions using planar capacitor structures. We observe an increasing field acceleration factor with decreasing thickness possibly suggesting different, slower, degradation mechanisms being present in the thinner dielectrics leading towards more reliability margin for scaled interconnects.


This paper presents a magnetically integrated isolated bidirectional three-port DC-DC converter (TPC) that includes an integrated dual active bridge converter (DAB) and non-isolated bidirectional DC-DC converter (NBC), each of which can be independently controlled. The proposed TPC simultaneously uses large, small, and magnetizing inductances, of which the small and magnetizing inductances are used for the DAB function, while the large inductance is used for the TPC function. The proposed magnetic component can function as any of the three inductances in the TPC. We constructed a 750 W, 175 kHz prototype of the proposed TPC along with an example of a conventional TPC and measured their respective efficiencies. The results show the efficiencies of the integrated TPC were all above 90% across the entire range of output power and were nearly equal to those of the conventional device. However, compared to the conventional type, the magnetic components in the proposed converter were 10% smaller, and the overall size of the converter was 33% smaller.


Peristaltic transport of two fluid model with micropolar flui d in the core region and Newtonian fluid in the peripheral layer is studied under t he assumptions of long wavelength and low Reynolds number. The linearised equations governing the flow are solved and closed form expressions for pressure rise, time averaged flux and frictional force have been obtained. The effects of various parameters on these flow variables have been studied. It is found that the pressure rise increases wi th micropolar parameter (m) and central mean radius (�), but decreases with coupling number (N ) and viscosity ratio (¯ µ). The frictional force ( ¯ F ) decreases with coupling number (N ) and viscosity ratio (¯


To identify the various areas and to undertake to comment briefly about each area would not only be difficult but would also be grossly unfair to the depth of the insights given by the author in each area. However, anyone who knows Bruce Larson would know that he places strong emphasis (and rightly so) upon relationships. Even to mention this might conjure up thoughts of shallow and superficial relationships, but this is certainly not what the author suggests in a wide variety of settings. One other emphasis might be lifted out for special attention. Helping people become whole can best be done through the ministry of the laity. With this conclusion this reviewer is in complete agreement. It is not necessary, Larson says, for a person to know all of the psychological theories or to have training in specialized techniques. The basic essential, rather, lies in the quality of the relationsip.


The effects of 3'-azido-3'-deoxythymidine (AZT) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine on myeloid and erythroid colony-forming cells were studied by clonogenic assays. Both consistently inhibited granulocyte-macrophage CFU (CFU-GM) and erythroid burst-forming units in a dose-dependent fashion. Concentrations of AZT and 9-(1,3-dihydroxy-2-propoxymethyl)guanine required for 50% inhibition of CFU-GM were, respectively, 0.9 +/- 0.1 and 2.7 +/- 0.5 microM; those required for 90% inhibition were, respectively, 34.0 +/- 2.8 and 35.7 +/- 3.6 microM. Erythroid burst-forming units were less sensitive to high concentrations of AZT than were CFU-GM.


Relationship between glutathione-peroxidase activity of blood plasma, red blood cell haemolysates and 10.000 g supematant fraction of liver homogenate and sorne carcass traits of rabbits was investigated. The carcass traits were estimated by CT method and determinad after slaughtering. The correlation between the above mentioned parameters was different depending on the tissue where the enzyme activity was measured. The results also suggest that the selection, oriented to the improvement of dressing traits, as genetic effect could independently influence the dressing traits and glutathione-peroxidase activity.


We present a methodology for quantifying the effect of MIMO radar on tracking association performance. Two general factors affecting contact-to-track association are included. The first is a decrease in measurement error, in both Doppler and azimuth. The second is an increase in detection probability (due to enhanced discrimination of slow-moving targets from the clutter ridge), which effectively decreases the average time interval between track updates. The approach quantitatively evaluates the decrease in the probability of a track association error with a MIMO radar, to efficiently assess the design trades of system parameters.


The improved method of seismic hazard analysis,based on mode superposition technique,is applied to calculate the main vibrating parameters(mainly PGA,PGV and response spectra) for any engineering site by considering its surrounding historical earthquakes,geological structure and wave propagation characters.The estimated parameters by this method can be adopted as a basis for earthquake-resistant design of structures.


Nothing lasts forever. Not people, not redwood trees, not empires, not climatic conditions, not even the Sun and Earth and certainly not an organizations success formula. Regardless of how strong and successful an organization is, and regardless of how long a period of success the organization has had, the need for change is inevitable. In some instances, the need for change occurs because of changes in the environment. This can be due to changes in customer's tastes and preferences, changes in technology, changes in the nature of competition, or other external factors beyond the control of management. The need for change can also occur because of the organizations own success. Changes in organizational size and complexity as a result of growth and market success create the need for changes in organizational structure and possibly, culture. The "secret" of long term success is the ability to adapt to change. Organizations develop "success formulas" or "winning business models" that last for a period of time. Then, as the environment changes or conditions within the organization itself change, the enterprises must adapt. If it does so successfully, it will continue to exist and flourish. If it does not adapt successfully, however, it will experience difficulties and perhaps failure, regardless of how strong it appears at a moment or how many resources it has. The decline can occur swiftly or agonizingly slowly over a long period of time. This study will be designed to assess the implementation and effectiveness of change management practice in public developmental agencies in North Gondar, particularly in Gondar town. On the basis of data collection through questionnaires which are founded on t he theoretical assessment of related literatures; research tries to unearth some of the real practice of change management based on the opinion of the respondents in particular organization. The population and target population of the study comprises all employees (managers as well as non managers) currently working in the public developmental agencies located in Gondar town. The researchers used both stratified and systematic random sampling techniques in selecting the research subjects. Stratified sampling technique is used to stratify employees who are currently working in these eight organizations into managers and non managers. Then appropriate number of respondents has been allocated and selected from each stratum and PDA's using systematic random sampling technique.


Documation 2014: The CEO of Jalios presents the results of his company in 2013, a declination of Jalios JCMS solution for SMEs to "democratize collaborative" and promotes "hunt in packs" between software editors to develop internationally. [...]


The calyx-krater from Orvieto in the Louvre which is the eponymous vase of the Niobid Painter has come into the scholarly spotlight again during the last decade as a result of Erika Simon's penetrating discussion of the iconography of the main scene (Fig. i).1 Recently Kristian Jeppesen has made it the subject of two long articles which have contributed several cogent observations about the relationships of the figures and, a contribution for which every student of the vase must be grateful, a splendid series of new detailed photographs.2 Though both scholars have rejected the association of the main scene with Marathon which was suggested by Friedrich Hauser in Furtwangler-Reichhold,3 their new observations seem, at least to one who has become preoccupied with Marathonian iconography, to support rather than to weaken this connection. In this article I do not wish to criticize in detail the alternative explanations that Simon and Jeppesen have proposed but simply to outline what seems to me to be going on...


Aim:  To assess the critical tooth number (CTN) required for prevention of subjective dysphagia caused by oral impairments and to evaluate the relationship between this CTN and mortality.


Self-assembly and self-selection of a single linkage isomer of a mixed-metal molecular triangle with ferrocene functionality have been achieved using an ambidentate ligand, and the product was characterized by multinuclear NMR spectroscopy and X-ray single crystal structure determination.


The Nano Particles (NP) metal playing an increasingly important both in industrial processes and in biomedical research. However, data on potential toxicity to living organisms remains insufficient. The aim of this work was to study the effects of semiconductor nanomaterials (CdSe) on a bio indicator species in ecotoxicology, the land snail Helix aspersa. The snails were injected with increasing concentrations CdSe for 03 months. We sought to evaluate the effects of oxidative stress on the digestive gland and by monitoring the activity of certain enzyme biomarkers: GST and catalase. We also measured the levels of reduced glutathione and total protein. Malondialdehyde (MDA) considered as a biomarker of lipid peroxidation was also measured. Thus, the neurotoxicity of CdSe was confirmed through the measurement of Acetylcholinesterase (AChE). Our results show an increase in the activity of antioxidant enzymes (GST, catalase, MDA) and decreased GSH levels in the digestive gland, as we have also identified a neurotoxic effect CdSe results in reduced activity Acetylcholine Esterase (AChE). DOI: 10.29011/AESET-102.100002


The current condition, where the rapid flow of globalization and technological progress is increasing so that everything regarding foreign countries will be easily and unlimited.The impact of this current of globalization has caused the fading of the spirit of nationalism and patriotism among the younger generation.Many factors cause the fading of the spirit of nationalism, but one of the biggest is that foreign cultures are more considered modern and according to the times so that they are more likely to like and be interested in the culture of foreign countries.By using a qualitative method with a descriptive approach with data used based on literature studies based on references from previous research on the role of pancasila in growing awareness of the nationalism of the younger generation in the era of globalization.The results obtained in this study, namely Pancasila, play an important role in growing nationalism awareness, because pancasila is the ideology and basis of the state.Pancasila is the basis of all things, so the life of individuals, communities, nations, and countries must be in accordance with ancestral values and values contained in every precept of pancasila.


The use of patch clamp methods for identifying ion-specific channels and other transport structures in plant cell membranes is described. Methodology, basic concepts that underlie data analysis, and applications of this powerful technique are emphasized.


Single-crystal SiC has been widely applied for electronic devices. Photocatalysis assisted chemical mechanical polishing (PCMP) is an efficient global flattening technology for finishing SiC, but the atomic level removal mechanism is still under discussion. In this paper, the atomic behavior of removal with hydroxyl free radical (·OH) aqueous solution was investigated using the ReaxFF molecular dynamics (MD) simulation. The theoretical analysis shows that ·OH oxidation of SiC can occur spontaneously, and the mechanical behavior would be able to increase the potential energy and reduce the reaction barrier the reactants. The simulation results show that with only chemical oxidation occurs, the SiC surface adsorbed O, H or -OH to produce Si-O*H2, Si-OH2, Si-OH, Si-H2O, Si-H*O*-H2O, Si-H2O*, Si-O*H* and Si-H, etc, no Si atoms were observed to detach from the SiC substrate. Nevertheless, if the mechanical action was applied, some Si and C atoms break off the substrate by forming SiO, SiO2, CO, CO2 or chain, and the other Si or C atoms were detached by the adsorption on the abrasive. In addition, no atoms break away from the substrate in H2O solution. The force F x in H2O solution is less than that in ·OH aqueous solution because of the lubrication of H2O solution. Furthermore, it is found that the mechanical action applied, the more -H and -O adsorbed on the SiC surface result in the more Si and C atoms are removed. The experimental results show that SiC wafer could be oxidized by ·OH under the mechanical action of diamond abrasive particles. This study reveals that the removal of Si and C atoms from the substrate is the result of the combined action of chemical oxidation and mechanical sliding, which is helpful to explain the dynamic process of the oxidation and removal of Si and C atoms on the atomic level in the SiC PCMP. Furthermore, it provides a valuable method reveal the material removal mechanism.


The paper addresses two instances of link partitioning problems in communication networks: dedicated and shared partition allocation problems. These problems belong to the class of nonlinear nondifferentiable integer optimization problems which are difficult for conventional nonlinear integer programming methods to find global optima. We use a genetic algorithm for solving these problems. Possible partitions of a communication link are represented as chromosomes to which genetic operators are repeatedly applied to find better solutions. Comparative experimental results show that the genetic method outperforms uniform partitioning and a conventional heuristic method for a wide range of offered load levels in multiclass calls.


The US is applying sanctions to Iran indiscriminately, contravening a moral and reputational imperative to ensure that American policies do not contribute to more COVID-19 deaths.


Central Hunan area is a world-famous area for Sb (Au) mineralization. This paper has systematically studied carbon, hydrogen, oxygen, sulfur, lead and strontium isotopic geochemical characteristics of Sb (Au) deposits in central Hunan and discussed sources of ore-forming metals and ore-forming fluids. The researches show that the ore-forming metals such as Sb and Au came from basement clastics, while the ore-forming fluids were mainly derived from meteoric water.


Gauge theory approach to consideration of the Nambu-Goldstone bosons as gauge and vector fields represented by the Cartan forms of spontaneously broken symmetries, is discussed. The approach is generalized to describe the fundamental branes in terms of $(p+1)$-dimensional worldvolume gauge and massless tensor fields consisting of the Nambu-Goldstone bosons associated with the spontaneously broken Poincare symmetry of the $D$-dimensional Minkowski space.


Background This study aimed to investigate resilience as a protective factor for depressive mood and anxiety among Korean employees. Methods Participants were employees of eight private and local government organizations in Korea, aged 19 to 65 years. A self-report questionnaire that included items on resilience, job stress, levels of depression and anxiety, and socio-demographic factors, was administered to 1,079 Korean employees, with 1,076 valid responses. We performed hierarchical linear regression analyses with the levels of depression and anxiety scores as dependent variables. Results Being women and having a high level of job stress were associated with greater depressive mood and anxiety. In contrast, resilience was negatively related to depressive mood and anxiety, after adjusting for demographic variables and the level of job stress. Among the five factors for resilience, "support" and "hardiness" were protective factors for depressive mood and anxiety after adjusting for demographic variables and the level of job stress. Conclusion Based on the results of the current study, we suggest that focusing on the resilience of employees, especially on "support" and "hardiness," factors as well as developing and engaging in interventions that increase resilience in the workplace, can protect against depressive mood and anxiety, especially for those with high levels of job stress.


Currently, the teaching of geography and history, lack of efficient strategies for the pedagogical, geographical and historical training at all levels, gener...


reaching imperial expansions" (pp. 82, 9) are unfortunate choices which reify popular stereotypes of a single unified narrative of an "Islamic invasion of India", contrary to recent scholarship which emphasizes the Hindu–Muslim encounter as a longer, more heterogeneous and translational process. The final three chapters are dedicated to the modern period. The impact of European merchants and the establishment of British rule to 1857 is the subject of chapter 10: "Europeans". British rule is treated first in terms of territorial acquisition and then in terms of its increasing impact on Indian society, economy and political life. Chapter 11, "The nation state", examines the growth of Indian Nationalism through nineteenth-century socio-religious reform movements, the high politics of the Indian National Congress and the biographies of Gandhi and Jinnah. The volume ends with chapter 12, "New nations", in which, under the rubric of nation state, economy and society, Trautmann gives a succinct sketch of each South Asian nation from 1947 to the present day. Surprisingly no mention is made of either communal violence or language politics – arguably two of the most significant strands in Indian political life. Finally an important concluding discussion analyses the conflicting views of the past of Indian civilization that form part of each nation state's self-definition. In sum, Trautmann largely succeeds in his ambitious goal, producing a compact, readable narrative that makes 5,000 years of Indian history accessible to undergraduates and the interested lay-reader alike. Inevitably, specialists will find grounds for dissatisfaction, whether authorial decisions about compression, or occasional sleights of hand which veer towards uncomfortable generalizations. This is particularly the case with chapter 9. Yet, despite such concerns, this book is a remarkable achievement, and will certainly go a long way towards meeting the needs of the target audience.


We discuss ways of improving navigation facilities in hypertext systems, considering theoretical and implementation issues, from a natural language processing research perspective. The key claim is that certain ideas from the theory of discourse structure can be exploited to improve the context-sensitivity of navigation facilities. In particular, (i) after a node is reached by a jump, links to other nodes can by dynamically suppressed where these are rendered irrelevant by the user's mode of arrival; and (ii) at any point after a jump (or sequence of jumps), the user can easily return to a limited set of structurally accessible nodes. The approach therefore combines certain advantages of navigation based on document structure with those based on individual interaction histories. The ideas have been tested by altering the implementation of Info, the hypertextual help system built into the Emacs text editor, which runs on Unix, Macintosh and pc systems. Evaluation studies are currently being planned, and we see further potential for exploiting notions from discourse structure to inform the design of navigation aids.


Emission measurements were performed on a series of σ−π conjugated organosilicon copolymers, −[(SiMe2)mA]n− (m = 1, 2, 3, 4, and 6), with alternating dimethylsilylene and π-conjugated units (A = phenylene, diphenylene, and anthranylene) in various solvents. The copolymers with m ≥ 2 exhibit a broad emission ascribable to an intramolecular charge transfer (CT) excited state resulting from the charge transfer between the dimethylsilylene and aromatic units. The solvatochromism of the emission spectra was observed for the organosilicon copolymers, where the emission maximum shifted to longer wavelength in polar solvents. The influence of the dimethylsilylene chain-length and the π-conjugated unit on the CT emission was investigated. The molecular orbital calculations on a model compound suggest that the vibronically structured emission is attributed to the π-character of the aromatic unit, and the structureless broad emission is ascribed to the σ-character of the Si−Si bond in the excited states. The emissio...


A new method, theoretically justified, is proposed to overcome difficulties in analysing reliability data coming from Type I censored samples. The article shows that, by means of Monte Carlo simulations, it is possible to obtain quasi-exact likelihood estimator properties and conservative confidence intervals for log-location-scale distributions. In the case of the exponential distribution, comparisons with the exact estimator properties show that the Monte Carlo approach allows to calculate the properties with very good accuracy. Finally, for the exponential distribution it is demonstrated that, if the number of failures can only be different from zero, confidence intervals based on the asymptotic properties of the likelihood estimators may give statistically meaningless results in the case of small sample size (3–10) and low probability of failure (.05–.20).


This paper discusses welfare costs of a decrease in productivity and argues that there are two important channels which cause a reduction in welfare: a decrease in output per firm (intensive margin) and a decrease in number of operating firms (extensive margin). Traditional Dixit-Stiglitz monopolistic competition framework with constant elasticity of substitution utility and common productivity across firms fail to capture the extensive margin. To address this problem, this paper introduces "continuum-quadratic" utility (i.e. linear demand system) while keeping the other assumptions unchanged and finds that lowering productivity affects not only the intensive but extensive margin as well.


Rare earth elements are metals that show unique characteristics in a range of applications for the new technological paradigm.This research aims to assess the environmental impacts in connection with the production of rare earth elements from a Brazilian ore; the Life Cycle Assessment methodology, was employed. Modeled data were collected from a monazitebased productive system that possesses the characteristics associated with the Brazilian scenario. According to the results hereby obtained, the main environmental impacts of the rare earth eements production are those associated with the climate change categories related to health and eco-systems, urban land occupation and fossile fuel depletion, of which the most contributive inputs are the hydrocloridric acid and ammonium hydroxide.


It was 10.10 pm when I entered the British Museum with my booking paper printed from the internet. I was due to see the Terracotta Army at 10.20 pm, my scheduled time; visits to the exhibition being arranged like this as booking is overwhelmed, with the Museum staying open until midnight on Thursdays and Fridays.

Just entering the museum at this time, with darkness outside and the entrance and hall virtually empty, is fascinating. But watching the exhibition is spectacular; you travel back to a time when human civilisation was at its height in Egypt with the Pharaohs, in Greece, in Italy with the Etruscans and the Romans.

Three hundred years BCE … and you enter …


Pandemic covid-19 precedes education to adapt with this disruptive situation. The needs of teaching and learning continuity suggests online learning as one of the solutions along with its challenge. This study aim to investigate whether gender differences influence demotivating factors of EFL Learners of Indonesian Undergraduate Student during pandemic covid-19 situation Surveys design was utilized to verify the hypothesis in this research. On the basis of Kikuchi's (in press) qualitative study, this study employed 34-item questionnaire that consist of five categories;((a) Course Books, (b) Inadequate School Facilities, (c) Test Scores, (d) Noncommunicative Methods, and (e) Teachers' Competence and Teaching Styles) to gather quantitative data. Having cluster random sampling as sampling technique, the participants were 368 EFL Learners of Indonesian Undergraduate Student from private universities in Jakarta. The findings of the research revealed that gender did not influence demotivation factors on online learning during pandemic situation. However, the finding indicated the absence of face-to-face teacher in online learning significantly influence demotivating factors on learning English, as non-communicative approach and teacher performance being the most cited factors. Additionally, the result of the study can be the basis of further research on demotivating factors in learning English.


Monsanto has been making thermoplastic sheets with tinted color gradients since the 1950s. But novel technology commercialized more recently has pumped new life into the product. The thermoplastic sheets are intended for use as interlayers between sheets of glass for vehicle windshields or in architectural applications. Monsanto's new Saflex process has substantially reduced production costs, improved product quality, and enhanced Monsanto's market position. It also has earned the employees who developed it recognition by the company. Saflex interlayers are polymer sheets imbedded between layers of glass to improve safety by limiting danger from flying glass following an impact. Most interlayers made today are also colored for control of incident sunlight. Therein lies a problem. It is desirable to vary the density of the color across the glassinterlayer composite. Typically, a windshield is more densely colored at the top. Prior to development of the new Saflex process, the conventional procedure for mak...


According to the family-centered approach, the involvement of family in the care of hospitalized older patients is a crucial element of quality care. Active involvement of family in care by the nursing staff depends on different factors, including attitudes towards the importance of family in the care and perception of the interactions with the family. This study aims to identify the factors predicting staff behavior of involving the family in the care process. A cross-sectional study was conducted among 179 nursing staff at a hospital, using a self-report questionnaire examining staff attitudes towards the importance of family in care, the perception of the interactions with the family (family behavior, communication and conflicts), and staff behavior toward family involvement. The findings point out the importance that staff attitudes have on their behavior in the active involvement of family in the care of older patients. Staff behavior of family involvement was predicted by their perceptions of the family (as conversational partners and having their own resources), less conflicts with the family, and staff academic education. Staff behavior toward family is influenced by their attitude and staff–family relationships. Educational programs should emphasize the importance of family, as well as dealing with conflicts.


With the rapid development of domestic hotel industry,key employees have gradually become important strategic resources for existence and development of hotels,and played a crucial role in the management and sustainable development of hotels. How to keep on hotel key employees fundamentally is the problem demanding prompt solution. This paper defines the concept of hotel key employees,and analyses their characteristics,needs and current situations. At last,based on their characteristics and needs,it analyses the ways to train and keep on them from the whole process of human resource management.


AbstractMoringa oleifera is a plant with multiple uses. Among them, the best-known use of seeds is as natural coagulant for the clarification of turbid water. The process of preparation of the natural coagulant generates different wastes including Moringa seed husk. This work studies the use of this waste as biosorbent for cadmium and copper removal. Adsorption studies were performed using batch test and the effects of contact time, temperature, pH, concentration of metal, and concentration of adsorbent were also analyzed. We have also studied the biosorbent structure through SEM and EDX. Experimental results were analyzed using Langmuir and Freundlich isotherms and the adsorption kinetics by pseudo-first and pseudo-second-order equations. The experimental results showed that the maximum removal of Cu and Cd was observed at pH 6, 1 h contact time, 1 mg/L initial concentration of Cd and 2 mg/L of Cu, and 1 g of biosorbent added. The percentages of metal removal were around 90% for both metals studied. Resu...


80 Background: There is increased evidence that cancers of the upper GI tract are comprised of distinct epidemiological and molecular entities that may respond differently to anti-cancer therapy in Asian patients compared to North American patients. Everolimus, an oral inhibitor of the mammalian target of rapamycin (mTOR) showed clinical promise in a phase II study in Japanese patients with pre-treated metastatic gastric cancer with a disease control rate of 56% (Doi et al, JCO, 2010). This study evaluates the efficacy and safety of everolimus in patients with pre-treated metastatic gastric and esophagus cancers in a US population.

METHODS
Patients with advanced upper GI adenocarcinomas who experienced disease progression despite 1-2 prior regimens were treated with everolimus 10 mg PO daily. The primary endpoint was disease control rate (DCR; CR+PR+SD). Secondary end points included progression free survival (PFS), toxicity, overall survival (OS) and translational correlatives of the mTOR pathway.

RESULTS
Of the 40 patients enrolled to date, 19 have gastric, 7 have esophagus and 14 have tumors from the GEJ. 32 patients are evaluable to date: median age of 59 (range 36-79), all patients had an ECOG of 0 or 1; 11 (34%) received 1 prior regimen and 21 (64%) received 2 prior regimens. We observed 0 responses with 44% of evaluable patients having stable disease. Median overall survival was 5.6 months (95% CI: 3.2-7.6) and PFS was 1.8 months (95% CI: 1.6-2.2). 89% of all adverse events were grade 1-2, and 11% were grade 3-4. Grade 3-4 related adverse events include: fatigue (24%), thrombocytopenia (22%), anemia (9%). Updated results of translational correlatives with the mTOR pathway will be presented.

CONCLUSIONS
We did not achieve the same degree of overall survival or disease control as in the Japanese study which may reflect differences in the locations of the primary tumor or underlying geographic variation. However, OS is significantly better than best supportive care reported in a recent randomized European trial (Thuss-Patience PC et al, Eur J Cancer 2011). Results of the randomized Phase III trial of everolimus vs best supportive care in this patient population are pending.


Mining frequent patterns in databases is a fundamental and essential problem in data mining research. A continuity is a kind of causal relationship which describes a definite temporal factor with exact position between the records. Since continuities break the boundaries of records, the number of potential patterns will increase drastically. An alternative approach is to mine closed frequent continuities. Mining closed frequent patterns has the same power as mining the complete set of frequent patterns, while substantially reducing redundant rules to be generated and increasing the effectiveness of mining. In this paper, we propose a method called projected window list technology for the mining of frequent continuities. We present a closed frequent continuity mining algorithm, ClosedPROWL. Experimental result shows that our algorithm is more efficient than previously proposed algorithms. Temporal databases, association rules, Mining methods and algorithms


This paper describes the over rolling tests with the Kalibra lorry carried out at a Maurer modular swivel joist expansion joint situated at the Bridge near Ewijk on motorway A50 over the river Waal in the Netherlands. The dynamic behaviour of the joint was measured and analysed by the EMPA. The objectives of the tests were the vertical and horizontal load transfer: Dynamic amplification factors, upswing after unloading, damping and relation to real traffic. The characteristics were related to the fatigue life of these structures.


Development in any nation is a function of leadership and good governance at any level. However, there is no doubt that Nigeria faces some challenges of development where it has been argued that one of the factors that has militated against the initiatives for developments by various governments in Nigeria since independence in 1960 is that of leadership and good governance, which fails to embrace the culture of accountability and proper management of public resources there by, resulted into poverty and hunger among the people, as well as political and social instability in the country. This paper seeks to examine the concept of leadership and good governance as they relate to the challenges of development in Nigeria. The methodology employed in this paper is content analysis and largely from secondary sources of data. Thus, relevant books, journals, magazines, newspapers and internet materials were analyzed to determine ways in which poor leadership and lack of good governance have been the obstacles to development in Nigeria. The paper concludes that, for effective and sustainable development to be achieved there must be a link between the elements of good governance and leadership which includes accountability, rule of law, transparency in the management of resources as well as absence of corruption among others.


Abstract : This report describes the results of questionnaire designed to assess Navy on-the-job training (OJT) practices. The questionaire was based on shipboard observations and on model of the on-the-job trainer as a coach who guides the trainee through a task using three steps: (1) assessment (2) training and (3) evaluation. The questionnaire was sent to over 5,000 shipboard supervisors: 2,321 responded. Three major conclusions can be drawn from the information and data provided in the report. First, OJT is an important component of the Navy training process and should become even more important as the Navy increases the emphasis on shipboard training in the coming years. Apprentice training and 'A' school training do not and will not produce personnel capable of independently performing jobs. Second, very few shipboard petty officers receive information or training on how to conduct OJT. Third, while over 50% the supervisors reported that they used appropriate OJT techniques, at least 20% do not, and another 30% are not as effective as they could be. Evidence from tutor training can improve performance of both tutors and the students they train. Therefore, there is both a need and a capability to improve the quality of shipboard OJT


It has been shown that in xenotransplantation of human cells into immunodeficient mice, the mouse strain background is critical. For example, the non-obese diabetic (NOD) strain is most efficient, the BALB/c is moderate, and the C57BL/6 is inefficient for human cell engraftment. We have shown that the NOD-specific polymorphism of the signal regulatory protein-alpha ( Sirpa ) allows NOD SIRPA to bind human CD47, and the resultant "don't eat me" signaling by this binding prevents host macrophages to engulf human grafts, thereby inhibiting rejection. We then developed the C57BL/6. Rag2 null Il2rg null strain harboring NOD-specific Sirpa , named the BRGS mouse. The efficiency of human cell engraftment in BRGS mice was equal to that of NOD. Rag2 null Il2rg null mice. These findings clearly show that in addition to depletion of lymphocytes, inactivation of phagocytosis via the CD47-SIRPA interaction is one of the critical determinants to establish an efficient xenogeneic transplantation system. Here we tested whether the efficient xenotransplantation capability of the BALB/c strain is also mediated by the SIRPA-CD47 self-recognition system. BALB/c SIRPA was capable of binding to human CD47 at an intermediate level between those of C57BL/6 SIRPA and NOD SIRPA. Consistent with its binding activity, BALB/c-derived macrophages exhibited a moderate inhibitory effect on human long-term culture-initiating cells in in vitro cultures, and showed moderate phagocytic activity against human hematopoietic stem cells. DNA sequencing of the SIRPA IgV domain located in the CD47 binding site in each strain was performed. We identified 2 SNPs unique to BALB/c mice, and 3 SNPs unique to both BALB/c and NOD mice. Among these 5 SNPs, BALB/c strain has a Val residue at the 29 th amino acid, whereas all other mouse strains have a Leu residue. Introduction of C57BL/6 SIRPA carrying the L29V mutation into C57BL/6 conferred the binding affinity to human CD47 equivalent to that of BALB/c SIRPA, indicating that L29V mutation at least contributes to the enhanced binding of BALB/c SIRPA to human CD47. Thus, BALB/c-specific L29V polymorphism in SIRPA renders to be able to recognize human CD47. Our data strongly suggest that the mouse strain effect on xenogeneic engraftment might be ascribed mainly to "macrophage tolerance" based on the binding affinity of strain-specific polymorphic murine SIRPA with human CD47. This information should be useful to develop a novel immunodeficient strain with superior efficiency for xenogeneic transplantation of human cells. Disclosures: No relevant conflicts of interest to declare.


Single-nanoparticle two-photon microscopy shows great application potential in super-resolution cell imaging. Here, we report in situ adaptive optimization of single-nanoparticle two-photon luminescence signals by phase and polarization modulations of broadband laser pulses. For polarization-independent quantum dots, phase-only optimization was carried out to compensate the phase dispersion at the focus of the objective. Enhancement of the two-photon excitation fluorescence intensity under dispersion-compensated femtosecond pulses was achieved. For polarization-dependent single gold nanorod, in situ polarization optimization resulted in further enhancement of two-photon photoluminescence intensity than phase-only optimization. The application of in situ adaptive control of femtosecond pulse provides a way for object-oriented optimization of single-nanoparticle two-photon microscopy for its future applications.


Qualitative, descriptive-exploratory research of the case study type, carried out with six teachers and 23 students, data production was by semi-structured interview and focus group. For the data analysis, the SECI knowledge conversion model was used: socialization, externalization, combination and internalization.


Real estate development project usually contains three stages: obtaining ownership of land, building and selling. But for the decision-making of an investment, the traditional NPV method can not exactly evaluate the flexible value of management. With an introduction of the real option theory, this paper points out that real option is a right to choose the real project investment. For the real estate development investment projects, the investment option of subsequent stages is to be owned after finishing every stage. Aiming at the decision-making of the three-stage investment in real estate development project, this paper sets up a relative real option model and provides the option value as well as the critical prices at the best investment point of each stage.


At present, the successful operations of the fourth party logistics (4PL) in practice gradually demonstrate that it is an effective mode to integrate the supply chain's complicated resources rationally, efficiently and flexibly. In order to thoroughly analyze the supply chain resources integration problem in 4PL from a quantitative perspective and to guide the integration practice, based on the previous study results, this paper takes the multi-objective optimization action of the integration decision as an analysis pivot, builds a improved ant algorithm to resolve the integration decision optimization process. Finally, the reasonability and feasibility of the algorithm are validated through the simulation of a calculation case.


The photoluminescence (PL) of annealed porous SiO2 film embedded by Si nanocrystals (Si-NCs) has been found emitting blue-light at room temperature deposited by plasma-enhanced chemical vapor deposition(PECVD) at near-atmosphere pressure. The SiO2 films obtained by PECVD had rare Si-NCs embedded in them. The blue-light emission peak located at 418 nm of porous SiO2 films was faint because their surface was passivated by hydrogen. In order to improve the PL intensity, the deposited films were annealed in primary gas at 500°C for 3 hours. Compared to unannealed films, the PL peak of annealed films shift from 418 nm to 397 nm, and the intensity strengthened obviously. The transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR) revealed that Si-NCs emerged after annealing while Si-H bonds decreased. Si-NCs were thought as the origin PL of 397 nm. The decrease of Si-H irradiative centers improved the PL intensity.


Traditional phonetic analyses of stops have recognized three phases: onset, closure, and release. Using data from an expanded version of UPSID [I. Maddieson and K. Precoda, J. Acoust. Soc. Am. Suppl. 1 86, S19 (1989)] and from an ongoing project on the sounds of the world's languages [P. Ladefoged and J. Choi, J. Acoust. Soc. Am. Suppl. 1 86, S75 (1989)], it will be shown that phonologically only two phases—closure and release—are exploited. For example, independent distinctions of phonation type cannot be found in the onset phase. Similarly, only the release stage may be distinctively lateral. The phonological restriction applies to stops made with pulmonic and glottalic airstreams (velaric stops are not discussed here). Language‐specific examples of contrasts in the closure and release phases are presented and some universal implications for consonant inventories are explored.


We develop the framework of boundary derivative expansion (BDE) formalism of fluid/gravity correspondence in a compactified D4-brane system, which is a nonconformal background used in top-down holographic QCD models. Such models contain the D4-D6 model and the Sakai-Sugimoto (SS) model, with the background of the compactified black D4 branes under the near-horizon limit. By using the dimensional reduction technique, we derive a 5D Einstein gravity minimally coupled with three scalar fields from the 10D D4-brane background. Following the BDE formalism of fluid/gravity correspondence in the conformal background, we directly derive all the first order transport coefficients for nonconformal gluonic matter. The results of the ratio of the bulk to shear viscosity and the sound speed agree with those obtained from the Green-Kubo method. This agreement guarantees the validity of the BDE formalism of fluid/gravity duality in the nonconformal D-brane background, which can be used to calculate the second order transport coefficients in nonconformal background.


An accurate description of the transition corridor is of great significance for the flight process of the vertical take-off and landing (VTOL) fixed-wing unmanned aerial vehicle (UAV). To study the transition flight process of vertical take-off and landing fixed-wing UAVs, the dynamic model and transition corridor model of this type of UAV are established in the current article. The method for establishing the model is based on a reasonable match of the power and aerodynamic force of this type of UAV. From the perspective of flight dynamics, the ducted lift-increasing system's deflection angle–speed envelope is studied with the maximum lift coefficient of the wing and the system's available power. The influence of the overall parameters and energy parameters of the UAV on the deflection angle–speed envelope of the ducted lift-increasing system is analyzed, and a method is proposed to expand the vertical take-off and landing fixed-wing UAV's transition corridor. Taking the UAV as the object, using the established model, the transition flight corridor of the UAV is obtained, the influence of the control parameters on the transition flight is studied, and the appropriate transition flight control strategy is determined. At the same time, the influence of the overall parameters and energy parameters on the transition corridor is calculated. According to the calculation results, the effect of expanding the flight corridor of the UAV is more obvious when increasing the available power than when increasing the aerodynamic parameters by the same proportion.


We are delighted to see a cross-discipline review article by Chong, Sinclair and Guymer appearing in this issue of CEO ('Facts on fat', pp. 464–471). As the authors anticipate, this review provides valuable information to readers of the Journal, who are mostly ophthalmologists. We also believe that this cross-discipline review article will enable readers to better understand the roles of dietary fats, and be in a position to convey better quality information to their patients. Given that a possible association between dietary fatty acid intake and age-related macular degeneration is a current hot topic in the ophthalmic literature, this review article is well worth reading.


Although negative energy densities are predicted by relativistic quantum field theories, I present an argument that an "operational" positivity still holds: the energy in a region, plus the energy of an isolated device which traps or measures that energy, must be positive. If we assume Einstein's field equation, this means the local geometry of a negative energy-density region cannot be measured by the trajectories of test particles.
So far, all attempts to design thought-experiments to verify a classical local geometry in the negative energy-density region have failed. It seems we must impute a quantum character to such a space-time regime.


The dependence of the signal strength of radio waves upon ionospheric focusing and spatial attenuation is calculated for a spherical ionosphere in terms of parameters obtainable from the appropriate vertical incidence ionogram. The signal strength at any given distance can be presented as a function of these ionospheric parameters in the form of a contour chart from which the unabsorbed field strength can be obtained easily as a function of frequency. The geometrical optics approximation is used. The limits of the region at the skip distance for which this method fails are estimated by comparing the results of a ray- and a wave-type calculation.


In this work, the thermal diffusivity and thermal effusivity properties of the (Bi0.5Na0.5)0.935 Ba0.065TiO3 lead-free ferroelectric ceramics are studied since it can be use as pyroelectric detectors. Photoacoustic and photothermal techniques were used to determine thermal diffusivity and thermal effusivity respectively. The preparation of the ceramics was perform in our laboratory by using the oxide-mixing conventional method. The ceramics present high value of thermal diffusivity compared with barium Titanate. All measurements were made at room temperature.


A two-tap dispersion-insensitive photonic microwave bandpass filter based on optical single-sideband (SSB) polarization modulation is proposed for long-reach radio over fiber applications. The optical SSB polarization modulation, which generates two complementary intensity-modulated signals along two orthogonal polarization directions, is implemented by a polarization modulator (PolM) followed by an optical filter. With a polarization maintaining fiber (PMF) to introduce a time delay, a two-tap dispersion-insensitive photonic microwave bandpass filter is obtained. The proposed filter is used to shape a Gaussian pulse to an ultra-wideband (UWB) signal. After 40-km fiber transmission, no distortion in the waveform of the UWB signal is observed.


[Abstract] Hayabusa was moving near Asteroid Itokawa for about three months in 2005. Using tracking and navigation data such as range, Doppler, distance from the asteroid, and optical images taken by navigation cameras, we estimated the mass of Itokawa for several orbital phases. The results are consistent in their error ranges. The estimated mass of Itokawa is 3.51 ± 0.105 ( 10 10 kg), from which the density of Itokawa is derive d as 1.9 ± 0.13 (g/cm 3 ). This is one of the important characteristics to understand the nature of Itokawa. We are also trying to investigate the accuracy of the ephemeris of this asteroid.


The latest displacement and velocity sensors such as LDV and LiDAR have limited application in large-scale civil structures, because it is difficult to find an appropriate sensor installation position on which the sensors can aim at the measurement point. Instead, GPS-RTK is widely applied to large civil engineering structures, but GPS-RTK has low sampling rate, accuracy and precision, and is frequently affected by environmental conditions such as bad weather and surrounded obstacles. In the study, a new structural response measurement system has been developed for the online measurement of displacement, velocity and acceleration of large-scale civil structures. The proposed system estimates the structural responses with high sampling rate, accuracy and precision by fusing measurements obtained from GPS-RTK and accelerometer based on two-stage Kalman filter. The proposed system has the following advantages over GPS-RTK sensors: (1) 6 DOF displacement, velocity and acceleration can be measured simultaneously with a single sensor system, (2) The accuracy (around 2 mm) and sampling rate (up to 100 Hz) of the proposed system are better than those of GPS-RTK, and (3) The performance of the system is less affected by environmental conditions. To verify the performance of the proposed system, a field experiments at Yeongjong grand bridge was performed.


Abstract Feeding sugar syrup to honey bee colonies inside their hives doubled their collection of kiwifruit pollen in trials during the 1984 flowering season. There was, however, no significant increase in the colonies' collection of other types of pollen.


British Welfare State's negative effects emerged day by day in 1970s.So,Mrs.Thatcher reformed the Welfare State wholly and modestly and wished to keep a positive balance between welfare state and economic progress.Her reformation made welfare state more durative in Britain,at same time,it did bring some negative effects.In a word,the reformation is the base for the later,so it is historic.


Locoregional recurrence  is the most frequent cause of death of patients  with SCCHN. At present day clear guidance on the irradiation volume, total dose and timing of radiation re-treatment of these patients  are missing. 20 patients  with histologically confirmed locoregional recurrence  of HNSCC, received reirradiation. Median time after primary radiotherapy course was 37 months.  The treatment volumes and total doses were formed as follows: GTV (primary lesion and involved lymph nodes, delineated on CT, MRI and 18 F-FDG PET-CT)+CTV (0,5–1,0 cm) + PTV (0,3–0,5 cm) was treated  to the total dose equivalent  to 66–70 Gy of conventional  fractionation,  the upper  neck (if indicated,  levels I–III+PTV 0,5 cm) to 60 Gy, the lower neck (if indicated,  levels IV–V+PTV 0,5 cm) — equivalent to 50 Gy. Single doses to these volumes were 2,14–2,21 Gy, 2,0 Gy and 1,8 Gy, respectively. Treatment was planned using IMRT and VMAT techniques with SIB (Simultaneously Integrated Boost). Daily positioning  inaccuracy was less than 3 mm at lymph nodes PTV and less than 1 mm in OARs of CNS and optic pathways. 19 of 20 patients  received full course of radiation therapy without a break. Radiation toxicity manifested with grade 2 oral and pharyngeal mucositis and grade 2 radiation epidermitis. Relief time of radiation mucositis and dermatitis was the same to primary radiotherapy course. Oneyear OS was 48%. Using technique of SIB with IMRT and VMAT during curative reirradiation of recurrent HNSCC is available with maintaining  satisfactory tolerability.


Gallium Nitride (GaN) based light-emitting diodes (LEDs) suffer from the persistent issue of high resistivity of the p-type layer, due to inefficient dopant activation at room temperature. Here, a novel Electrostatic Field Effect LED (EFELED) is demonstrated to solve this issue by introducing significantly more holes into the LED active region for the first time. An increase in drive current is observed through application of positive biases to a capacitor layer on top of a 436 nm InGaN/GaN LED. With a positive bias of 5 V applied to the capacitor, the EFELED showed more than a two-fold increase in optical output from electroluminescence (EL) measurements, as well as over 115% enhanced external quantum efficiency (EQE). Modulation of holes can also be achieved through the novel capacitor integration in the EFELED, which leads to light output control. This proposed EFELED provides an alternative method to efficiently improve hole injection for the active region through energy band bending, which addresses the fundamental p-type doping issue for LED devices.


Abiotic formation of aliphatic lipid compounds (i.e., fatty acids, alcohols, and acylglycerols) has been reported to occur at elevated temperatures and pressures under simulated hydrothermal conditions (McCollom et al., 1999; Rushdi and Simoneit, 2001, 2006). Although abiotic chemistry may occur at these conditions, the prebiotic self-assembly of micelles to bilayer to vesicles (protocells) may have occurred elsewhere. Amphipathic compounds such as fatty acids and acylglycerols are important candidates for micelle/bilayer/vesicle formation. Thus, it is of interest to demonstrate that abiotic lipids (amphiphiles), precursor compounds for abiotic cellular membranes (Deamer, 1997), can be synthesized under hydrothermal conditions.


In this paper, we address the challenging problem of radio positioning in non-line-of-sight (NLoS) conditions. To this end, we utilize measurements in the form of time-of-flight and gNodeB angular information in the context of 5G New Radio (NR) networks. Such measurements are processed by artificial neural networks with different snapshot and sequence-processing architectures to track the positions of the terminals. For model training, we consider a crowdsensing data acquisition scheme to effortlessly gather the desired measurements with the synchronized location tags. Realistic ray-tracing based evaluations on the so-called Madrid map at 28 GHz millimeter-wave band are provided, to assess the achievable performance while also varying the amount of uncertainties within the data. The obtained results show that radio positioning is feasible with accuracy in the order of 1 meter, or even below, also in challenging NLOS scenarios if the data and measurement uncertainties are small. The results also show that the sequence processing approach offers superior performance under practical measurement uncertainties.


The one-pot synthesis of the title species (IV) involves condensation of dihydrofuran with glycolaldehyde dimer (II) followed by lipase-catalyzed kinetic resolution.


To reduce the cost of the e-beam curing composite manufacture,the minimum e-beam energy value to fabricate laminate stepwise cured on both-side irradiation is analyzed,and the effect of the dosage distribution on the interlaminar shear strength(ILSS)of carbon fiber/epoxy matrix composite is discussed.The experiments indicate that the uniform curing can be accounted for the preferred penetrating radiation while 125 keV is set as the radiation energy.Compared with the composite bearing equal irradiation on both side,the ILSS in composite bearing unequal irradiation can be enhanced by 7.5%(from 61.7MPa to 66.3 MPa).The optical microscope,SEM and DSC observations reveal that the greater difference for ILSS results from the active functional group amount in interlayer determined by the distribution of radiation dosage.


Described here is a tri-stable-state memory cell using Josephson junctions as switching elements. In contrast to all previously reported superconducting Josephson memories where information is stored in binary form,the tri-stable-state memory cell stores information in ternary form and at higher density than with the conventional bi-stable memory loops. The principle of operation and design criteria are discussed.


The characteristic feature of the retina of Lepidosiren paradoxa is the hugeness (20–25 μm) and sparse-ness of the cells which compose it. The epithelial layer is well pigmented. The visual cells may be classified into rods and single cones which possess a large oil droplet and a smaller paraboloid. Neither the epithelial pigment nor the visual cells show retinomotor responses. Landolt's clubs arising from the bipolar cells and terminating amidst the epithelial cell processes are present and resemble those of another Dipnoan, Protopterus. The ratio of photoreceptor, bipolar, and ganglion cells is about 2:2:1, indicating a very low degree of summation. There is no noticeable difference among the dorsal, vental, temporal, and nasal regions of the retina. The similarity of this retina to that of other dipnoans and urodeles is briefly discussed. It appears as if the growth of the eye were arrested (neoteny) during the evolution of this genus because of the insignificant role of vision in its life.


A survey of the decolonisation era in the Pacific, leading to independence for fourteen nations, but continuing and varied forms of colonial possession by nine other entities. The essay argues that decolonisation is unfinished business in the Pacific.


Aim: The aim was to study the occurrence of tetracycline resistance determinant tetA gene, and antibacterial resistance pattern in commensal Escherichia coli recovered from healthy non-clinical layer chickens. Materials and Methods: Twenty-four cloacal swabs were obtained from 15 flocks in five different layer farms located at around Namakkal, which is a place of high-intensity layer chicken rearing in south India. Identification of E. coli was carried out by performing cultural and biochemical tests. Antimicrobial resistance test was carried out using disc diffusion method. The polymerase chain reaction employing tetAC forward and tetAC reverse primers were carried out to detect tetA gene conferring resistance to tetracycline. Result: All the collected cloacal swabs yielded E. coli. Twenty-one isolates (88%) were resistant to tetracycline antibiotic in disc diffusion method. All the isolates showed resistance to more than six antibiotics, which implied existence of multidrug resistant microbiota in intestine of poultry. Only seven (29%) isolates showed the presence of tetA gene indicating the involvement of either other one or more efflux gene(s), namely tetB, tetC and tetD or ribosomal protection encoded by tetM, tetO, tetQ and tetS genes than tetA gene. Conclusion: Based on the presence of tetA gene among tetracycline-resistant bacteria in healthy non-clinical food-producing animals such as layer chickens, it can be significant in human medicine as tetA gene could easily be spread to other bacteria. This kind of phenomenon can be extrapolated in transfer of resistance for other antibacterial essential for treating bacterial infections in human. We conclude that preventing the spread of antimicrobial resistance through direct or indirect contact, consumed food/feed and through the environment is empirical in reduction of failures while treating bacterial infections.


atic power relationships inherent to the genre. Palmer argues, "a middleclass writer who works for the national literary market does not destroy the place but rather indexes the way that the place acts upon the middle-class writer" (10). Palmer's chapters focus on Caroline Kirkland, Eliza Farnham, and Rose Terry Cooke; Bret Harte and Sarah Orne Jewett; Rebecca Harding Davis and Thomas Detter; William Dean Howells; and Elizabeth Stuart Phelps. Her work is historically grounded, attentive to the text as a site of meaning, and an engaging read. Readers of Western American Literature will no doubt be particularly interested in her discussion of Kirkland and Harte, but her central argument about the way a narrative motif can express the complexities of region is also provocative and well worth consideration.


This thesis concentrates on the possibilities of obtaining various kinds of grants and on the budgetary process in the small village Horni Heřmanice. It analyzes their obtaining for the period of 2009 - 2013. This thesis describes accounting for grants, with links to budgetary structure of the village. Based on the offered subsidies are recommended selected grant programs to ensure the development of the village.


I read with great interest an article "Impact of Tofacitinib on Components of the ACR Response Criteria: Post Hoc Analysis of Phase III and Phase IIIb/IV Trials" by Bessette et al.1 The authors carried out an extensive study on clinical response to tofacitinib (TOF) in patients with rheumatoid arthritis (RA) and concluded that a divergence between physician- and patient-reported measures highlights the importance of identifying appropriate patient-reported outcomes to manage RA symptoms in a clinical setting.


Malignant and benign neuroendocrine tumors (NET) share many histopathological features. Liver transplantation (LT) is one of the liver-directed therapies for neuroendocrine liver metastases (NELM). The aim of this study was to determine the outcomes of patients undergoing LT for NELM.


This article presents two algorithms to control the speed of doubly-fed induction motors. The controllers are designed using the complex-valued sliding mode methodology to track either the rotor or the stator current. An outer loop controls the mechanical speed. The control schemes are validated experimentally and compared in a laboratory setup.


The temperature dependence of the I–V parameters of different III–V multi‐junction concentrator cells at several concentration levels was investigated. Moreover, the influence of spectral changes on the temperature coefficients of multi‐junction solar cells was examined. Complete sets of temperature coefficients of a metamorphic Ga0.35In0.65P/Ga0.83In0.17As dual‐junction cell, a metamorphic Ga0.35In0.65P/Ga0.83In0.17As/Ge triple‐junction cell and a lattice‐matched Ga0.50In0.50P/Ga0.99In0.01As/Ge triple‐junction cell determined under well‐controlled laboratory conditions are reported. Copyright © 2012 John Wiley & Sons, Ltd.


PURPOSE:To prepare 1-oxadethiacephalosporin having heterocyclic thio group in high yield without lactonization, from a free acid having a halomethyl group at 3-position without protecting the carboxyl group of the free acid.


Mid-air haptics is an emerging technology that can produce a sense of touch in mid-air using ultrasound. While the use of mid-air haptics has a lot of potential in various domains such as automotive, virtual reality or professional healthcare, we suggest that the home is an equally promising domain for such applications. We organized an ideation workshop with 15 participants preceded by a sensitizing phase to identify possible applications for mid-air haptics within the home. From the extensive set of ideas that resulted from this, five themes emerged: guidance, confirmation, information, warning and changing status. As general 'application categories', we propose that they can provide a useful basis for the future design and development of mid-air haptic applications in the home, and possibly also beyond.


The article analyzes the factors influencing the process of political and legal theory of state sovereignty in the context of globalization and European integration. Analysis of systematic research shows that the most important features and characteristics of state sovereignty in domestic and foreign literature are two properties: the supremacy of state power and the independence of the state from other sovereign states from the outside. It was found that the very nature of state sovereignty, the genesis of the formation, modification and development of its concept are conditioned by globalization and integration processes in the world, and above all, within the European Union. It is argued that state sovereignty will continue to play a key regulatory and institutional role in international relations, but at the same time, it is becoming more multilevel and multi-component in relation to Ukrainian society. It is proved that by declaring the Ukrainian state sovereign, independent, the Constitution of Ukraine enshrines not only what has been achieved, what is real in its functioning and development, but also a kind of perspective of the idea of sovereignty. The comprehensive study focuses on the implementation of state sovereignty, which depends not only on historical, sociological and international legal factors, but also on the ability of Ukrainian society to overcome economic difficulties, complete the legal framework, increase financial stability and efficiency, state extra-budgetary social funds. It was found that the realization of the sovereign rights of the Ukrainian state in the context of globalization and European integration requires a new understanding, new approaches and new practices to solve global problems of human civilization, preserve international peace through legal principles that shape the global and regional legal space. It is proved that modern Ukraine is not yet sufficiently involved in globalization and European integration processes, and in modern relations the state's participation in these processes is carried out by the country's citizens.


This paper reports on the recent advancement of the GRANEX technology platform developed by our group for power generation from low-grade heat sources. The technology is particularly suited to applications involving geothermal power generation and waste heat recovery. By combining the concepts of heat regeneration and supercritical Rankine cycle into a unified process, GRANEX improves the thermal efficiency of the cycle and increases the net electrical output which can be recovered from a given low-grade heat source. The regeneration of the thermal energy in GRANEX is achieved through a novel heat regenerator invented and patented by our group in partnership with Granite Power Limited (GPL). Development of GRANEX dates back to early 2006 when a Research and Development Agreement was established between the University of Newcastle and GPL. In conjunction with a program of fundamental studies an applied program of work was undertaken for proof of concept and prototype development with the assistance of a REDI grant from AusIndustry (2007-2009). By 2008, a 1 kW prototype had been built and experimental trials of the system had been completed, demonstrating considerable advantages over conventional systems in terms of both thermal efficiency and power generation (about 40% improvement). This was followed by the design of a 100 kW pilot-plant in early 2009. The pilot-plant is currently under construction and is due to be commissioned by late November 2009.