This article analyzes how Jonah is incorporated within the Synoptic Gospels, particularly Mark and Matthew. In addition to looking at the well-noted "sign of Jonah" passages Matthew and Luke, as well as at the clear allusion to Jonah found in the Stilling of the Storm episode in all three Synoptic Gospels, we suggest that there is a more over-arching use of Jonah in Mark and Matthew that runs from the Beelzebub controversy in Mark 3:20–35/Matthew 12:22–32 to the Transfiguration in Mark 9:2–32/Matthew 17:1–23. This larger Jonah-theme within Mark and Matthew points not only to the explicit connection between Jonah's three days in the great fish and Jesus' three days in the tomb, but also to the larger issues of Jesus' identity, the nature of the Kingdom, and the mission to the Gentile world.


The users can get the knowledge from centralized shared resources at any place and any time in e-learning by means of cloud computing technology. However, it is not clear the influence of Quality of Service on the e-leaning environment. In this paper, we investigate the influence on e-learning under Virtual Desktop Infrastructure by using a network emulator. In each case that we set the various values as QoS parameter, we observe subjective and objective responses of users. The purpose is to clarify the relationship between network quality of service and e-learning usability.


The issue of suicidal behavior in adolescents is one of the most disturbing and complex. The present work is aimed to draw attention to the problem of suicidal behavior in adolescents in modern Russian reality. While analyzing cases of severe injuries due to suicidal behavior in adolescents who were admitted to the Clinical and Research Institute of Emergency Pediatric Surgery and Trauma (CRIEPST) in Moscow (Russia) , the authors stated their significant increase in recent years . In 2016-2023, 58 children after suicidal attempts were hospitalized to CRIEPST. All children were teenagers (11-17 years old). The authors not only noted an increased risk of suicide in 14-16 age group of teenagers, but they also noted gender features in this group. Two groups of suicide causation were defined as well: psychopathological processes and affective, impulsive reactions. After summarizing findings obtained in CRIEPST , the researchers have stated an increase in the number of psychopathological predispositions in children in the recent years. An increased number of cases with suicidal behavior in adolescents and predominance of psychopathological processes as risk factors should make adults be more attentive to tendencies in suicide causation and their prevention. The data presented in the article are preliminary and incomplete, as they do not cover cases that did not lead to severe somatic consequences.


Objective:To compare the efficacy and safty of two kinds of dust mite vaccines for the treatment of dust mite-allergic rhinitis patients.Methods:80 patients with dust mite-allergic rhinitis were divided randomly into two groups:group A(35 cases,injection of domestic dust mite vaccine);group B(45 cases,injection of import dust mite vaccine).All patients were treated for one year.Results:80 patients completed the study.By the end of therapy,the significant effective rate was 91.43% for group A and 91.11% for group B,with no significant difference between them(P=1.0000.05).11 patients of the group A had local side effects only,and there was no systemic side effect appearing.39 patients of the group B had local side effects,and 4 had systemic side effect.Conclusion:Dust mite vaccines home-produced and imported both are effective and safe drugs for the dust mite allergic rhinitis patients.You can choose between them on the basis of practical situation.


Among infants younger than 12 months diagnosed with GERD, weak evidence supports the use of proton pump inhibitors (PPIs) and histamine H2 antagonists. Among children 12 months and older, studies have shown moderate benefit from PPIs and weak benefit from H2 antagonists for providing symptomatic relief and/or improving histologic or pH indices of disease.


An accelerated test matrix is outlined that includes acceptance, baseline and post-cycling tests, chemical and physical analyses, and the data analysis procedures to be used in determining the feasibility of an accelerated test for sealed, nickel cadmium cells.


Wavelength space can be subdivided into intervals of constant solar flux. This defines a spectral grid, referred to as solar flux numbers in this paper. The spectral irradiance expressed in units of irradiance per solar flux numbers has useful properties: it has no Fraunhofer structure, and is equal to the transmittance because the solar source function is constant in irradiance units per solar flux numbers. This representation of spectral irradiance has utility in atmospheric radiation and modeling by simplifying the quantitative analysis of the energy budget.


To the Editor: We read the article by Avramescu et al. published in Anesthesiology with great interest.1 The authors investigated the effect of interleukin-1β on the γ-aminobutyric acid (gABA) inhibitory currents in hippocampal and cortical neurons after exposure to etomidate or isoflurane in vitro. They arrived at their findings with the use of a mice model of sepsis consisting of intraperitoneal lipopolysaccharide injection. They were able to show some interaction between lipopolysaccharide and some, not all, measures of behavioral effectiveness of two anesthetics. overall, results described seem to offer insight on the potential relationship between inflammation and the amount of anesthetic needed In Reply: i thank Dr. trubuhovich for reminding Anesthesiology's readership and me that the Doctors Fothergill were native yorkshiremen and not scotsmen. in preparing for my February 2016 editorial,1 my files boasted a copy of Dr. trubuhovich's2 June 2006 article, but they lacked a copy of his september 2006 correction.3 That is certainly my failing and not Dr. trubuhovich's.


Shielding Computer Program 14-0 evaluates point-topoint attenuation functions and integrates over source regions to perform reactor-shield penetration calculations for neutrons and gamma rays. Neutron dose rates and gamma ray flux and dose and energy absorption rates can be computed for positions in and around complex reactor shields containing multiple sources described in a cylindrical coordinate system. In addition, the program can compute reactor- shield weight. Computation of any or all of these quantities in a single problem is optional. Enough physical and souree deseription capability is provided by the program that nuclear analysis of reactor-shield assemblies currently considered at ANPD should involve little uncertainty except that assoeiated with point-to-point attenuation functions and secondary souree distributions. A modification of the Albfert-Welton theory of neutron attenuation is used for fast neutron dose rate calculations. Combination of buildup factors by empirical expressions is used with exponential attenuation to compuie gamma ray doae rates. The program is coded for use on an IBM-704 having 32,768 magnetic eore memory locations. Magnetic tape units are used for the production package and output. No magnetic drum memory is required. (auth)


Taking a tunnel as the engineering background, this paper focuses on the mechanism of large deformation of soft rock, the design and optimization of supporting technology, aiming at the problem of large deformation of tunnel surrounding rock. By means of numerical simulation, the failure mechanism of structural large deformation of layered surrounding rock is deeply analyzed and studied. The tunnel is simulated with different support parameters to find more reasonable support parameters and optimize the existing support. The results show that the displacement of surrounding rock increases with the increase of upper load. When the roof load is less than 0.7 MPa, the vertical displacement of the sensitive block tends to be stable after a certain period of time; When the top plate load is 0.7 MPa, the vertical displacement of the roof sensitive block cannot converge, so some reinforcement measures must be taken at this time. When the tunnel is supported by bolts, the longer the length of bolts, the better the effect will be. 3m anchor length should be selected for support, and other support methods should be added to control tunnel deformation.


This article discusses the problem of the recognition of collective identities in the context of a democratic state of law based on the interpretation sug


Abstract In order to enhance the stirring efficiency in the molten metal, a new electromagnetic stirrer by tilting the yokes to a certain angle was proposed. The main merit of this stirrer is that it can generate simultaneously both rotating and travelling electromagnetic forces. In the current work, a numerical model was established to calculate the electromagnetic and induced flow fields. The effect of the tilt angle of the yokes on the stirring efficiency was studied. It is found that when the tilt angle is increased from 15 to 30°, the maximum absolute value of the electromagnetic force in the vertical direction is double. The average absolute value of the electromagnetic force in the vertical direction reaches 1·26×10−2 N, which is more than half of the electromagnetic force in the x or y direction. The electromagnetic force in the vertical direction is strong enough to induce a meridional flow in the vertical section. The flow patterns driven by the traditional rotating magnetic stirrer and the new stirrer were compared. The results show that with the traditional one, the flow pattern is mainly annular. With the new one, however, both annular and meridional flows are achieved. Finally, effects of the various electromagnetic force on the microstructure of Sn–20 wt-%Pb were analysed.


The Carboxy‐terminus of Hsc70 Interacting Protein (CHIP) controls several aspects of protein quality control machinery through its ability to function as a co‐chaperone, autonomous chaperone, and ubiquitin ligase. CHIP is ubiquitously expressed in all tissues, but interestingly, CHIP expression is higher in certain tissues such as heart, muscle and brain, suggesting an increased dependence on CHIP function in these organ systems. This concept is supported by studies that show how altered CHIP function associates with several ailments such as cardiac diseases, neurological disorders, and cancer. Microtubules (MTs) are a part of the cellular cytoskeleton that provides shape and structure to cells. In addition to these roles, MTs play a crucial role in cell division, migration, intracellular organization and trafficking. Dynamic assembly and disassembly of MTs upon various stimuli is important for the proper functioning of differentiated cells and is a process orchestrated by multiple proteins. Dysregulation in the MT reorganization machinery is implicated in a similar spectrum of diseases associated with the loss of CHIP function, however, there has yet to be a direct connection between CHIP and MT dynamics. We performed a proteomics screen on wild type and CHIP−/− mouse embryonic fibroblasts and identified differential regulation of proteins that regulate several aspects of MT function, such as STMN1 and PDLIM. Given the importance of CHIP in protein homeostasis, we hypothesized that CHIP is necessary for proper MT dynamics in response to cellular stimulations. We found that CHIP is required for the phosphorylation of stathmin, a regulator of MT assembly, and for the tubulin polymerization in C2C12 myoblast cells following insulin and glucose stimulation. This stimulation triggers an important MT‐dependent process to mediate glucose uptake. Furthermore, ex vivo studies using muscle fibers isolated from CHIP−/− mice failed to form MT lattices after glucose stimulation, consistent with a new role for CHIP in regulating MT in muscle. Altered MT dynamics, as well as CHIP loss of function, are also implicated in neurodegenerative diseases, particularly those associated with proteinopathies. To determine if CHIP contributes to MT regulation in neurons, we used an immunoprecipitation‐mass spectrometry approach and identified changes in interactions between CHIP and MT proteins during proteotoxic stress. Future experiments will focus on validating the interaction data and further dissecting the specific functions of CHIP that contribute to the regulation of MT dynamics using biochemical approaches and imaging. In conclusion, for the first‐time, our data couple CHIP to MT dynamics, and suggest that CHIP may contribute to cell protection by regulating the proteins that are vital to MT dynamics.


UAV(Unmanned Aerial Vehicle) needs IMU, GPS, etc. to know positions, velocity, attitude information. Especially, GPS is weak and easily jammed by the unexpected interferences in urban environment. So in this paper, control law is presented using optical flow for UAV to avoid obstacles in urban environment. lucas-Kanade Methods is used for optical flow estimation. BWB is used to simulate and 3D urban environment is constructed by MATLAB Virtual Reality.


We report recent progress in optical signal processing of phase-modulated digital signals using the delay-asymmetric nonlinear loop mirror. With broadband polarization-insensitive wavelength conversion in the loop mirror, signal demodulation is achieved at continuously variable bit-rate over 3 Gbit/s. Following the demodulation, all-optical clock recovery is also demonstrated.


Representation of uncertain knowledge by using a Bayesian network requires the acquisition of a conditional probability table (CPT) for each variable. The CPT can be acquired by data mining or elicitation. When data are insufficient for supporting mining, causal modeling such as the noisy-OR aids elicitation by reducing the number of probability parameters to be acquired from human experts. Multiple causes can reinforce each other in producing the effect or can undermine the impact of each other. Most existing causal models do not consider causal interactions from the perspective of reinforcement or undermining. Our analysis shows that none can represent both interactions. Except for the RNOR, other models also limit parameters to probabilities of single-cause events. We present the first general causal model, that is, the nonimpeding noisy-AND tree, that allows encoding of both reinforcement and undermining. It supports efficient CPT acquisition by elicitating a partial ordering of causes in terms of a tree topology, plus the necessary numerical parameters. It also allows the incorporation of probabilities for multicause events.


The importance of this challenge arises from the difficulty of observing individual electrons and ions. In most plasmas, waves can only be detected by measuring quantities, such as number density or magnetic field, that lack information about individual particles. Imaging discrete particles as they move in the presence of a wave would greatly improve upon this situation, providing particle-level data with a richness that is usually seen only in simulations. Such imaging is possible with dusty plasmas [1-4], and less commonly with pure ion plasmas [5].


ABSTRACT This article identifies factors of NGO interventions that enable an escape from the poverty trap, through in-depth analysis of the life courses of at-risk youths engaged with an NGO in the Philippines slums. Applying the Trajectory Equifinality Model for interview analysis, the study found the following crucial factors: a mentor role based on continuous support between youths and NGO staff; comprehensive intervention for children, family, and community focusing on children's career and life planning; peer educators; and transitional work opportunities. The findings demonstrate lessons for the development community in policy formulation and the implementation of programmes to effectively tackle child poverty.


The problem of instability of diabatic flow between rotating, concentric cylinders was studied analytically. The basic equations were reduced to a form identical to that of a similar instability fluid flow problem, namely, the instability of a horizontal layer of fluid heated from below. The latter problem has been solved by Pellew and Southwell, and their solution was used to calculate and predict the instability of diabatic flow in the annulus. The results of the analysis show that heating of the inner rotating cylinder stabilizes the flow, while heating of the outer stationary cylinder destablizes the flow. (auth)


A detailed study of the impact of New Physics (NP) operators with differ- ent Lorentz structures, which are absent in the Standard Model Hamiltonian, on the B → K ∗ 2 (1430)µ + µ − decay is performed. In this context, the various observables such as branching ratio, forward-backward asymmetry of leptons, lepton polarization asymme- tries and the helicity fractions of the final state K ∗ 2 (1430) meson have been studied. We have examined the effects of new vector-axial vector, scalar-pseudoscalar and tensor type interactions for this decay B → K ∗ (1430)µ + µ − by using the constraints on different NP couplings which come from the Bs → µ + µ − , B → Xsµ + µ − and ¯ B → ¯ K ∗ µ + µ − decays. It is found that the effects of V A, SP and T operators are significant on the zero position of AFB(q 2 ) as well as on its magnitude. In addition to this these NP operators also give sig- nificant effects on the differential decay rate, lepton polarization asymmetries and helicities fractions of final state K ∗ (1430) meson.


The variation in the frost structure on a number of microgrooved brass surfaces is examined through an experimental study. The microgrooved samples are 45 mm x 45 mm in dimension with a broad range of groove dimensions. Frost is grown on these microgrooved surfaces under natur al convection for a range of plate temperature (-8 to -18 o C) and relative humidity (30-70%) conditions. The frost st ructure on the microgrooved surfaces, especially at the early stages of frost formation, is found to be significa ntly affected by the groove geometry (i.e. groove d epth and pillar width). Coalescence of the condensed and hence frozen droplets, covering multiple pillars and grooves, is found to occur more frequently on the surfaces with shallow grooves and/or narrow pillars. For surfaces with in termediate groove depth and pillar width, a regular (brick-wal l-like) frost pattern on the pillar surface is obse rved. Thickness and density of frost layer on the microgrooved surf aces are also found to vary with the dimension of t he grooves in frost cycles up to 4 hours long. The relationships between frost structure, frost properties, and fros t melt-water drainage is discussed, emphasizing the importance o f these morphological features.


From the Publisher:
"Concurrent Systems, Second Edition" presents a modern approach to software systems, ideally suited to the needs of today's students and programmers. It focuses on those concepts in concurrency that play a vital role in the design of operating systems, database systems, distributed systems and communication networks.


Two studies examined relationships between infants' early speech processing performance and later language and cognitive outcomes. Study 1 found that performance on speech segmentation tasks before 12 months of age related to expressive vocabulary at 24 months. However, performance on other tasks was not related to 2-year vocabulary. Study 2 assessed linguistic and cognitive skills at 4-6 years of age for children who had participated in segmentation studies as infants. Children who had been able to segment words from fluent speech scored higher on language measures, but not general IQ, as preschoolers. Results suggest that speech segmentation ability is an important prerequisite for successful language development, and they offer potential for developing measures to detect language impairment at an earlier age.


Introduction Excess calorie consumption and reduced exercise have led to a growing number of individuals who are overweight or obese, with an estimated prevalence of approximately 65% of US adults and over 1.5 billion people worldwide (1). Obesity is associated with substantial health care burden, with an estimated annual medical cost of $210 billion (2). Excess weight gain is accompanied by ectopic fat deposition in extra-adipose tissue that contributes to the development of hyperlipidemia, insulin resistance (IR), and type 2 diabetes (T2D) (3, 4). This disease constellation, in conjunction with additional cardiovascular (CV) risk factors, significantly increases the incidence of CV disease (CVD), such as myocardial infarction and heart failure (HF). Thus, understanding the cellular and molecular processes that underlie cardiometabolic changes that occur during obesity is necessary for the design of optimal medical therapies to attenuate or prevent the sequelae of this disease. Endothelium as an arbiter of homeostasis versus disease. The vascular endothelium is a single layer of cells lining the entire interior surface of all vascular networks. Under normal conditions, the healthy endothelium controls vascular homeostasis by modulating vascular tone, maintaining blood fluidity and flow, controlling vessel wall permeability, and counteracting vascular inflammation (5). As such, endothelial dysfunction, or a failure of the endothelium to perform any of these critical functions, is essential in the initiation and progression of atherosclerosis and metabolic disease (6). Numerous reports demonstrated that dyslipidemia and hyperglycemia result in endothelial dysfunction (7–12). In addition, the release of proinflammatory cytokines (IL-6, TNF-α; refs. 5, 13) and adipokines (resistin; ref. 14) from inflamed adipose tissue (AT) can perturb endothelial function (15). Thus, endothelial dysfunction represents a pathophysiological link between metabolic and CV disease, and recent discoveries have uncovered an important role of the capillary endothelium and microvasculature in regulating metabolic functions under homeostatic and pathological conditions (16). As cardiometabolic disease progresses, so do vascular inflammation, remodeling, and dysfunction in all segments of the vasculature, including large conduit arteries, resistance vessels (arterioles), capillaries, and conductance vessels (veins and lymphatics). These changes can exacerbate cardiometabolic disease progression. Thus, this Review's goal is to highlight recent cellular and molecular data that implicate the vasculature as an initiating and instigating factor in atherosclerosis, IR, and HF development.


Geochemical and geochronologic studies emphasize the role of incremental growth of large magma chambers and associated complex magma processes. One of the major results of these studies is that volcanic and plutonic rocks tend to consist of different crystal populations recording complex individual histories. Detailed geochemical observations of individual minerals provide direct access to petrogenetic processes such as magma mixing, assimilation and fractionation and their role for the evolution of the magma chamber.


201Background: Survival of glioblastoma remains grim. Identifying survival-associating factors may provide actionable targets for future research and clinical intervention to improve patient outcomes. Our study examined the association between multiple clinical and biochemical indices and survival in glioblastoma patients. Methods: 265 consecutive glioblastoma patients who received tumor resection between 1/1/2010 – 12/31/2014 were reviewed. Data about treatments (extent of tumor resection, radiation therapy, and use of temozolamide), medical history, vital signs, weight, and lab tests were collected. Charlson Comorbidity Index (CCI) was calculated with ICD-9 codes. Lab and vital signs data within 30 days of surgery were excluded from the analysis. Cox regression for survival analysis was performed. Results: The mean age of the population was 57.5 years, with 78% death rate. The median survival was 19.1 months. Systolic blood pressure, blood glucose, and serum albumin were significant factors for survival...


"Transient ischemic attack" (TIA) is a familiar term now very well known to practitioners, house officers, and students alike. Even patients frequently call their doctors, worried that they have had a "TIA." In this age of increasing media-centricity, we can expect even more hype and more patient and physician awareness of TIA and other putative "stroke symptoms." Yet the term and concept of TIA are relatively new. We owe to Miller Fisher the first detailed description and review of the phenomenology of TIAs, described as "prodromal k e t ing attacks of paralysis, numbness, tingling, speechlessness, unilateral blindness or dizziness," which nearly always preceded cerebral infarction in his patients with occlusion of the internal carotid artery.' This work was stimulated by Dr. Fisher's experience with a single patient who had episodes of transient right monocular blindness preceding a left hemiplegia. The patient remarked, "Isn't it funny that I went blind in the wrong eye?"2 Previously, Peabody3 and Oslefl had each described, near the turn of the twentieth century, patients with multiple TIAs. Most textbooks of medicine and neurology written before 1950 did not mention TIAs, but Gowers referred to "premonitory symptoms" before brain softening: and Gordone described a "preapoplectic period" during which patients had headache and other ill-defined symptoms before their strokes. In this issue of Neurology, two articles7s8 about TIAs both conclude: (1) TIAs are usually very short; the majority of episodes clear within 1 hour, and most patients with signs lasting 4 hours or longer develop strokes; and (2) some patients with clinical TIAs have infarcts shown on CT in locations appropriate to their transient symptoms. The finding of infarction by CT or other neuroimaging techniques is important and conclusively links TIA with cerebral infarction. Although Levy7 does not note the CT results of his patients, he does review reports that showed a range between 25% and 50% of positive CTs among four series of TIA patients. Werdelen and Juhlel.8 noted CT-documented infarcts in three of ten TIA patients. In addition to reports cited by these a number of others have also studied the incidence and location of ischemic lesions shown by CT and other imaging tests, such as magnetic resonance imaging and positron emission tomography, in patients with attacks meeting the definition criteria for TIAs. Nicolaides et ale studied 149 patients with hemispheric TIAs, 48% had an infarct on CT and 35% of the patients had an infarct in the symptomatic hemisphere. Fortythree percent of 70 patients with transient monocular blindness but no history of stroke or cerebral symptoms had infarcts on CT? Nicolaides et al analyzed the results of 17 studies of the frequency of infarcts on CT in patients with hemispheric TIAs. Of 783 patients, 154 (20%) had infarction on CT. Of 371 patients analyzed for the side of symptoms, 11% had infarcts in the symptomatic hemi~phere.~ MRI is clearly more sensitive than CT in documenting cerebral infarcts. In one study,'O seven of 22 patients with TIAs (32%) showed infarcts on CT (six in the symptomatic hemisphere) while 17 (77%) had infarcts on MRI (15 in the symptomatic hemisphere). Salgado et all1 also studied TIA patients with both CT and MRI. Of 21 patients with TIA or amaurosis fugax (two had a clinical stroke in the same vascular temtory as their TIA), eight CTs (42%) and 16 MRIs (84%) showed focal ischemia." Only 50% of the CT findings correlated with symptoms, but 81% of the abnormal MRIs had lesions appropriate to the symptoms. KinkleI2 found that 13 of 60 TIA patients (22%) had focal CT abnormalities, while 42 (70%) had MRI lesions in periventricular (12), cortical-subcortical (18), and watershed (12) distribution. Emission tomography13 and positron emission tomography also show a high incidence of abnormality in TIA patients.14-ls The cerebral metabolic rate for oxygen and the oxygen extraction fraction are often altered in the symptomatic region long after TIAs have resolved. The imaging data are very convincing that many patients with TIA have persistent, possibly reversible, brain tissue dysfunction, and probably at least one in four have a cerebral infarct. We do not know why symptoms are only transient in the patients with infarction. The finding that most TIAs are short is not new. In fact, we do not know of any study that has found otherwise. In the largest single study of TIAs, the NINCDSfunded Cooperative Study of Transient Ischemic Att ack~ , '~ 1,307 patients were analyzed; the median duration of attacks was 14 minutes in patients with "carotid artery symptoms" and 8 minutes in the "vertebrobasilar system" symptom group. Ninety percent of hemispheral attacks lasted less than 6 hours, and 90% of


The practice link is an essential teaching part of the Principles and Methods of Digital Mapping curriculum as the effect of theoretical study will ultimately be verified by practice. Therefore,how to arrange and organize the practice link of Principles and Methods of Digital Mapping in the teaching process is particularly important. This paper starts from classroom experiments,laboratories,practice base construction,experiment and practice teaching materials and other aspects to introduce the organization and implementation of the practice link of the Principles and Methods of Digital Mapping curriculum of Tongji University Excellent Curriculum.


In this book Peritz analyses how free competition has signified both freedom from oppressive government and freedom from private economic power. Peritz shows how these two complex yet distinct and sometimes contradictory images have influenced government policy and continue to inspire public debate over political economy in America.


This study tested the relationship between system quality, information quality, service quality, satisfaction, and continuance intention in online learning. Four hundred and thirteen college students participated in the survey and completed the questionnaires. The results verified the positive impact of system quality on satisfaction. The positive effects of information quality and service quality on satisfaction and continuance intention were also significant. Besides, satisfaction increased the continuance intention of online learning. These findings suggest that effective information and service quality may help universities increase the continuance intention of college students in online learning during the epidemic.


A range of both sol-gel and polymer derived sensor films have been developed for optical oxygen and pH sensing. Oxygen sensing is based on the luminescence quenching of the ruthenium complex [Ru(II)-tris( 4,7-diphenyl-1,10-phenanthroline)]dichloride, ([Ru(dpp)3] 2+ ), which is entrapped in the sol-gel matrix. The oxygen-dependent luminescence is detected using the principle of phase fluorometry, which facilitates indirect monitoring of the luminescence lifetime. The pH sensor uses excitation ratiometric detection of the fluorescence from the pH sensitive dye, 1-hydroxypyrene-3,6,8-trisulfonic acid, ion-paired with cetyl trimethyl ammonium bromide (HPTS_IP). The phase-based detection scheme, dual lifetime referencing (DLR), was also examined as an alternative sensing strategy. ORMOSIL oxygen sensor films were fabricated using a range of organosilicon precursors including methyltriethoxysilane (MTEOS), ethyltriethoxysilane (ETEOS), n-propyltriethoxysilane (PTEOS) and phenyltriethoxysilane (PhTEOS). In addition to optimising the sensor performance, issues such as the influence of humidity on oxygen sensing were addressed. By varying the processing parameters, the surface characteristics and microstructure were tailored to suit applications such as breath gas analysis and bioprocess monitoring. pH sensor films were prepared by hydrolyzing and co-condensing (3-aminopropyl) trimethoxysilane (APTMS) with an organosilicon monomer such as ETEOS or PTEOS or the polymer, ethyl cellulose (EC). Optimised pH sensors showed good reproducibility, reversibility and short response times. The dynamic range for these sensor films extends from pH 6.00 to 8.50 which is relevant for bioprocess monitoring applications. The spectral compatibility of the luminophores and the printability of the sol-gels present the possibility of simultaneous oxygen and pH sensing using low-cost LEDs as excitation sources along with common detection electronics.


Preface 1. Some general results in combinatorial enumeration Martin Klazar 2. A survey of simple permutations Robert Brignall 3. Permuting machines and permutation patterns Mike Atkinson 4. On three different notions of monotone subsequences Miklos Bona 5. A survey on partially ordered patterns Sergey Kitaev 6. Generalized permutation patterns - a short survey Einar Steingrimsson 7. An introduction to structural methods in permutation patterns Michael Albert 8. Combinatorial properties of permutation tableaux Alexander Burstein and Niklas Eriksen 9. Enumeration schemes for words avoiding permutations Lara Pudwell 10. The lexicographic first occurrence of a I-II-III pattern Torey Burton, Anant P. Godbole and Brett M. Kindle 11. Enumeration of partitions by rises, levels and descents Toufik Mansour and Augustine O. Munagi 12. Restricted patience sorting and barred pattern avoidance Alexander Burstein and Isaiah Lankham 13. Permutations with k-regular descent patterns Anthony Mendes, Jeffrey B. Remmel and Amanda Riehl 14. Packing rates of measures and a conjecture for the packing density of 2413 Cathleen Battiste Presutti and Walter Stromquist 15. On the permutational power of token passing networks Michael Albert, Steve Linton and Nik Ruskuc 16. Problems and conjectures.


ABS>A manual is presented which was prepared to serve as a training and operating guide for KAPL and USN personnel who perform radiation protection functions at the S3G facility. The S3G power plant, which consists of one reactor and one set of propulsion equipment, is used to evaluate the performance of the SSR(N)586 power plant in operation. The radiological hazards involved are summarized and instructions are provided for the operation of radiation protection instruments. Radiation exposure control limits, safe discharge limits for contaminated air and water, and methods of controlling and minimizing radiation hazards are included. (W. D. M)


We introduce symSpline: a symmetric, dual-mouse technique for the manipulation of spline curves. In symSpline, two cursors control the positions of the ends of the tangent to an edit point. By moving the tangent with both mice, the tangent and the edit point can be translated while the curvature of the spline is adjusted simultaneously, according to the length and angle of the tangent. We compare the symSpline technique to two asymmetric dual-mouse spline manipulation techniques and to a standard single-mouse technique. In a spline matching experiment, symSpline outperformed the two asymmetric dual-mouse techniques and all three dual-mouse techniques proved to be faster than the single-mouse technique. Additionally, symSpline was the technique most preferred by test participants.


Against a system of gender ideologies that defined a woman's social position and intellectual pursuits as private, devoted to domestic concerns and the moral welfare of her family, the emergency of the cortigiana onesta, the intellectual courtesan, dramatically calls into question the humanists' injunction against women's public status and speech. How did Veronica Franco, the foremost example of the cortigiana onesta in sixteenth-century Italy, succeed in infiltrating the "academy of learned men"? Were any restrictions placed upon her professional activities when she vied with men for public recognition and literary commissions? How did social forces contain or compel the courtesan's cultivation of a literary identity in Venetian society? And finally, what were the maneuvers, both personal and professional, that the cortigiana onesta adopted when she obtained entrance into an elite literary circle and allied herself with powerful male patrons and intellectuals?


In any study of the dissemination of ideologies, Marxism must claim a special place for two reasons. First, Marxism is both more precise and more all-embracing than any rival ideology, and its advocates claim not only that it is a "good" ideology but that it is the only correct ideology. Second, Marxism has been revised, by people who call themselves Marxists, in a way that would have astonished its founder.


The development of immune checkpoint inhibitors has been a major breakthrough in cancer therapy. Here, we report the effective use of the Goeckerman regimen in the treatment of an evolving immune checkpoint inhibitor dermatosis. The patient is a 67-year-old male who was diagnosed with mesothelioma in April 2015 and was started on pembrolizumab presenting with subsequent skin eruptions (psoriasiform dermatitis and bullous disease). He received eight months of Goeckerman therapy at University of California, San Francisco, Psoriasis and Skin Treatment Center. Within days of starting Goeckerman therapy, he had rapid improvement in his skin lesions along with a reduction in pruritus. The Goeckerman regimen is further discussed as a novel treatment method for checkpoint inhibitor dermatoses.


Objective To construct the eukaryotic expression vector of gene encoding 17 tandem repeats of human mucin 1(17MUC1 VNTRs),and express the gene in COS-7,HeLa and Lewis cells.Methods Synthesize 1MUC1 VNTR by PCR using the designed primer and clone into pGEM-T easy vector.Digest the constructed recombinant plasmid with SalⅠ and XhoⅠ,and ligate the digested product in turn to construct 17MUC1 VNTRs which was subcloned to eukaryotic expression vector VR1012.Transfect COS-7,HeLa and Lewis cells with the constructed recombinant VR1012-17m,then test for the transcription of mRNA by RT-PCR and the expression of 17m antigen protein by Western blot.Results Both restriction analysis and sequencing proved that the constructed recombinant plasmid VR1012-17m contained 17m gene.RT-PCR showed transcription of 17m mRNA in transfected COS-7,HeLa and Lewis cells.17m protein was expressed in all the transfected cells and showed specific reaction with McAb against MUC1 VNTR,as proved by Western blot.Conclusion The eukaryotic expression vector for 17m tumor antigen was successfully constructed and expressed in COS-7,HeLa and Lewis cells,which laid a foundation of further study on MUC1 vaccine and biotherapy of tumors.


A new theoretical approach to the unsteady detonation in condensed explosives was developed in our laboratory. The experimental results presented here represent the first study of the propagation of front waves moving transverse to the detonation front. It also appears that the velocity of these waves does not depend on the explosive confinement


BACKGROUND
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune and cyclophosphamide (CYC) is often used in the therapy of SLE. Anti-Müllerian hormone (AMH) is expressed in the ovarian granulosa cells and is a reliable biomarker for ovarian reserve. Recent studies have showed that SLE patients have lower serum AMH levels and CYC has a negative influence on ovarian reserve. But the results are conflicting in other studies. The objective of our study is to perform a systemic review and metaanalysis to confirm the relationship between SLE and ovarian reserve reflected by serum AMH levels as well as the effect of CYC on ovarian reserve of SLE patients.

METHODS
PubMed, Embase, Web of Science, CNKI, CHINESE WANFANG, China Science and Technology Database (VIP) databases were searched for eligible studies by two independent authors. Studies comparing serum AMH levels between SLE patients and healthy controls as well as serum AMH levels between SLE patients with and without the treatment of CYC were extracted. All statistical analyses were performed with STATA 12.0.

RESULTS
Totally 19 studies including 1,272 SLE patients and 555 healthy controls were included in our study. In a comparison of serum AMH levels between SLE patients and healthy controls, the pooled SMD was -0.79 (95% CI, -1.41 to -0.18) (P<0.05), indicating a significantly lower serum level of AMH in SLE patients. The results were repeated in subgroup analyses by region, diagnostic criteria of SLE and AMH detection methods. The therapy of CYC in SLE patients had a negative influence on serum AMH levels with the pooled SMD of -0.58 (95% CI, -0.87 to -0.30) (P<0.05).

CONCLUSIONS
SLE is related to increased risk of decreased ovarian reserve and the treatment of CYC can do harm to ovarian reserve.


This is the second interim annual report from a four-year longitudinal study of the social impact resulting from the Ministry of Defence's expenditure on cadets. The key themes covered by this report relate to Social Mobility and cadets' attendance, behaviour, and attitude at school. The report includes the views of schools, Ofsted and Cadet Force Adult Volunteers (CFAVs) on the benefits of cadets. In addition, this report comments on findings on the value and contribution of adult volunteers, cadets' health and wellbeing including special educational needs and disability, and the role which cadets can play in improving community cohesion. The report is based on data gathered from 202 in-depth interviews and 3,753 responses to questionnaires


This article draws on the experiences of teachers and teacher educators within the "Bristol Decolonising Network", an informal professional learning network based in South West England, to share examples of teacher-led decolonising/antiracist initiatives. The seven vignettes presented cover a range of subject areas across the English Secondary school curriculum, with varying rationales, foci, forms and intended outcomes. For this Special Issue, we look across these cases to consider links between teacher-led decolonising and antiracist initiatives and professional learning. We suggest that professional learning is both a condition for, and outcome of, teachers' engagement in such work; and that extending collaboration beyond hierarchical and institutional boundaries is a key enabler for progress on this agenda.


Previous research has acknowledged the widespread adoption of social networking (SNS) platforms for online shopping among social media users, known as social commerce. While the positive effects of shopping on social network platforms have received much attention in the literature, the negative outcomes of this type of commerce remain under-explored. Notably, the prevalence of cybercrime, specifically related to online purchasing fraud, has increased rapidly. To address this gap, this paper explores the online purchasing fraud cases related to shopping on the social network platforms, the demographic characteristics of the victims and the financial impact of the fraud to the victims. In addition, this paper also explores the strategies to mitigate the fraud cases. The data was gathered from social network users via an online survey. The findings show that almost seventy percent of the respondents were currently using social network platforms to shop, with Facebook being the most popular platform. For those who use social commerce, as many as twenty-four percent (24%) admitted to having been victims of purchasing fraud. The overwhelming majority of the victims were highly-educated middle-income earning married women, aged between 26–35. In terms of financial impact, the majority of the victims had lost nearly RM400. Few mitigation strategies were identified, including word of mouth, background check of sellers, reliable and transparent transaction process, and avoidance.


China's fertilizer industry is examined in a few aspects:the fast growth of phosphate fertilizer industry,promotion measures of some dominant phosphoric chemical and phosphate fertilizer enterprises,and finally,main problems and suggestions in the future.


Recent advances in artificial intelligence and data analytics have demonstrated that complex inputoutput relation can be learned by a deep neural network architecture when a large amount of training data is available. In development of data-driven soft-sensor for process control, there is always the concern whether sufficient physics were captured to allow for successful extrapolation and inference of other properties. To make up for the lack of important information, a dynamic model using past sensors readings and operating parameters was commonly used. However, simple input-output models in the form backpropagation neural work were shown to be unable to predict correct differential change of output (i.e. process gain), if the amount of data is not sufficient. To overcome this problem, one approach is to train a preliminary model using simulation data and use transfer learning to match plant data. It was found that gain consistency of the preliminary model can be preserved, while the prediction accuracy of the model can be substantially improved with only a limited amount of actual data. Alternatively, a semisupervised training approach can be used. A nonlinear state-space model can be formulated in an observer-predictor form using a sequence-to-sequence recurrent network encoder. The observer can be trained using the large amount of unlabeled data provided by flow, pressure and temperature sensors. This observer-encoder outputs a limited number of hidden states using unlabeled dynamic data in the past operating window. These hidden states and the current values of manipulated variables were then used as input for a predictor which can be developed with a limited number of labeled data. The gain sign is mostly consistent, indicating that sufficient physics was captured by the model.


Isobutyl-2-cyanoacrylate (Group I) and n-butyl-a -cyanoacrylate (Group II) were tested in two groups of dogs: Group I=13 dogs and Group II=12 dogs that had intestinal laterolateral anastomosis.The anastomosis were avaluated on days: 4, 14 and 28 after surgery. Adhesions between omentum and the surgical wall wound were grossly observed in both groups. Regarding the presence of adhesions comparing the two groups with unpaired t test, the difference between Group I and II is not significant (p=0,3624). Histology revealed inflammation and granuloma on the anastomosis with the adhesive inside of it both with isobutyl-2-cyanoacrylate and n-butyl-a -cyanoacrylate.


A hybrid micro-displacement sensor based on a Fizeau-type interferometer has been developed. The proposed sensor structure includes a polyimide waveguide, a distributed feedback laser diode, a two-segment edge-illuminated refracting-facet photodiode, a polarization beam splitter plate, a quarter-wave plate, and a beam splitter plate all on a silicon substrate (2 mm /spl times/ 3 mm). The sensor was fabricated by means of a passive alignment technique using alignment marks with an alignment accuracy of /spl plusmn/1 um. By using this sensor and an electronic feedback system, the position of a mirror actuated by a piezoelectric transducer can be servo-controlled. Nanometer-scale positioning of the mirror was accomplished with good stability against creep phenomena of the piezoelectric transducer.


For any given projective variety Y , we construct a projective variety X ⊂ P whose general fiber of the Gauss map with reduced scheme structure is isomorphic to Y when the characteristic > 0. Mathematics Subject Classification (2000) 14N05


Carcass was main product on cattle slaughtering which contain beef for human consumption and it has high nutritional and economical value. Carcass production on cattle has been influenced by several factors, such as cattle breed, feed, and body conformation. Cattle Butt Shape was one of part cattle body conformation which allegedly has have positive correlation on produced carcass. This research was aimed to evaluate Butt Shape condition influenced on Bali cattle carcass characteristic. The research was using Bali cattle which slaughter in Kendari Slaughtering House (Rumah Potong Hewan/RPH - Kendari). The observation includes weighing, and measuring parts of carcass was conducted on 60 heads of Halal process slaughtered Bali cattle which traditionally maintained. The research parameters were carcass productivity parameters i.e: slaughtering weight, carcass weight and length, leg length and circumstances. Obtained data were analyzed using Complete Randomized Design and post hoc analyzed using Least Significant Different if have any influence. The research result showed that cattle Butt Shape condition have significant (p<0, 05) influence on all Bali cattle carcass productivity parameters. Butt shape with B category was result the best carcass productivity compare the others, while C category was better than D. It can be concluded that body and carcass weight were linearly influenced by cattle butt shape.


This article from the overall tourism resources of Hefei,analysis of the nature and history of double degree about Hefei City,refining the Hefei city unique,that Hefei City Tourism New——"Arrow town image" and "An arrow two wings",The new tourism pattern.The new image and the dispersion pattern of tourism resources and city image promotion role and significance in the integration of city.


Ethane-1,2-diyl diacrylate was synthesized by esterification reaction of ethylene glycol and acrylic acid.Effect of catalyst content,acrylic acid content,ethylene glycol,inhibitor content,reaction time on the reaction of esterification was studied.The optimum reaction conditions were discussed:catalyst dosage is 1.7% of the total mass,mole ratio of acrylic acid to ethylene glycol is 2.5,inhibitor dosage is 0.6-0.7 g/mol AA.the mixture is stirred at 90-100 ℃ for 5 h.The products were identified by IR and 1HNMR.


103Rh, 31P and 1H NMR data are reported for the cyclometallated Rh(III) complexes of the type RhH(Y)()L2, where Y can be either an anionic or neutral ligand, is a carbon—nitrogen bidentate ligand arising from cyclometallation at the imine carbon of the Schiff's bases derived from 2‐amino‐3‐methylpyridine and substituted benzaldehydes and L can be either PPh3, AsPh3 or SbPh3. There is only a modest dependent of δ (103Rh) on the nature of the benzaldehyde, a substantial change as a function of L and the most significant sensitivity, >800 ppm, as a function of Y. It is suggested that 103Rh NMR spectroscopy may be useful in the study of linkage isomers of SCN−.


The dawn of old stars: Classic xanthene dyes like eosin Y (gr. eoς=goddess of dawn) and green-light irradiation can replace precious metal complexes for the organocatalytic asymmetric -alkylation of aldehydes rendering the process purely organic.


THE INVENTION CONCERNS A LIMIT ACCELERATION FOR TURBO-REACTOR. EC LIMIT ACCELERATION FEATURES A STORAGE HYDRAULIQUE10, A PISTON10A RESSORT10D AND WHICH RECEIVES A CHAMBRE10B PRESSURE IN PI REIGNING CIRCUIT3 FUEL, FROM A POINT P1 DE3, LOCATED uPSTREAM OF INJECTEURS2; INVENTION, THE OTHER OF CHAMBRE10C ACCUMULATEUR10 IS CONNECTED BY A CONDUITE11 OUTPUT COMPRESSEUR1A. LIMIT THIS ALLOWS TO ABSORB TIPS FUEL FLOW, RESULTS OF OPERATIONS OF THE BRUTAL SHUTTLE GAS, AND THAT WITH THE SAME EFFICIENCY DESPITE CHANGES PI, ESPECIALLY WITH aLTITUDE AIRCRAFT.


This paper considers the codification of wind loads in Australia with particular reference to Australian Standards AS 1170.2 and AS 3995. Meteorological aspects, and the way these are currently incorporated in the Standards are discussed. The calculation of wind pressures and forces and the dynamic effects on wind in relation to the two Standards are also addressed. Future developments are briefly covered.


This case study aims to dissect the world famous Wenzhou footwear manufacturing industry in order to discover how, if at all, the case complies with an industrial organisation framework, namely the industrial district model, which is becoming more and more prevalent in less developed countries (LDCs).

In order to examine the extent to which the industrial district model may have developed and advanced in Wenzhou's footwear industry, I aim to explore whether the typical features of the international model are present in the industry's structure, and if so, to what extent. I also aim to discover whether Wenzhou's footwear industry has any peculiar characteristics, which do not pertain to the international model.

In order to do so, this case study aims to extend a similar study conducted by Professor Khalid Nadvi and Professor Hubert Schmitz entitled "Industrial Clusters in Less Developed Countries: Review of Experiences and Research Agenda", using it as a tool to investigate the extent of Wenzhou's compliance with the industrial district framework. I attempt to add the example of the Wenzhou footwear industry to this discourse, which examines the Brazilian, Indian, Peruvian, Mexican and Italian footwear industries? adaptation of the industrial district model.


The classification of the acute leukemias depends mainly on the morphologic and cytochemical evaluation of the blast forms. One of the main accepted morphologic criteria in the differentiation between acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML) is the absence of granules in the blast cells of ALL. We evaluated a patient with ALL in whom granules were present in the cytoplasm of 35% of the blast cells, as seen in AML. Cytochemical evaluation was performed, including periodic acid-Schiff reaction, Sudan black B, alpha-naphthyl acetate, alpha-naphthyl butyrate, naphthol AS-D chloroacetate, and acid phosphatase stains. The results of these studies confirmed the morphologic impression and diagnosis of ALL. Ultrastructural evaluation revealed that the granules consisted of many tiny vesicles closely packed together in a proteinaceous matrix, resembling to some extent the inclusions described in lymphocytes in the Chédiak-Higashi syndrome, but clearly different. The morphologic, cytochemical, and ultrastructural studies of this unique case are presented in detail. To our knowledge, this is the first time that such granules have been described in blast cells of ALL.


Gliomas are the most common primary intracranial malignant tumors of the central nervous system. The most popular clinical strategy for glioma treatment is maximum surgical resection combined with radiotherapy and chemotherapy. However, the therapeutic effect of this strategy is suboptimal; the prognosis remains poor, and relapse is common. Moreover, this strategy does not significantly improve the duration of patient survival, and a complete cure remains elusive. In preclinical studies, it is necessary to establish a stable and reliable glioma model in order to develop new treatments and chemotherapeutic drugs for glioma. Different cell lines have different biological characteristics. Thus, it is essential to select the most suitable glioma cell line for model development based on the purpose of the study. Understanding the different chemotherapeutic agents used in glioma treatment can provide a drug reference for convection-enhanced delivery and help in the development of new drugs for this tumor. Convection-enhanced delivery technology enables drug transport across the blood-brain barrier, enhances drug targeting, and reduces systemic toxicity. Therefore, it has great potential in the chemotherapeutic treatment of glioma. This review summarizes the advantages and disadvantages of different glioma cell lines as well as the current progress in different chemotherapeutic drugs and convection-enhanced delivery for gliomas. It lays the foundation for new treatment strategies and provides a theoretical basis for the clinical application of these chemotherapeutic agents and convection-enhanced delivery techniques in glioma treatment.


The dynamic of direct and indirect runoff is decisive for the formation of landscapes and the nature and function of surface water systems. This in turn determines the size, dynamics and quality of surface water and ground water. The interactions associated with these processes are characterized by great complexity. Therefore, spot analyses or very localized sampling do not suffice to obtain the data necessary to unravel the surface and subsurface history of water movement in landscape and geological media. This, however, is necessary if integrated water resources management is to assure water supplies for our expanding populations, agriculture and industries. As in many countries drinking and irrigation water is primarily extracted from surface water and most surface waters have a subsurface history, both surface and groundwater systems and their interconnection had to be studied. There is now a wealth of knowledge documenting this, and the thematic issue presents some of these examples. The success of these five studies mostly is based on the application or analyses of isotope tracers, both natural and anthropogenically introduced. The review article by Rank et al. [1] presents an example for the application of isotope tracers in surface water runoff in large catchments in Central Europe over 50 years. These studies began primarily during the second half of the past century and paralleled the rapid development of hydrogeology, both in research and teaching. Progress in the interpretation of geochemical analyses and the beginning of hydraulic modelling are very well documented, and much of the work done in hydrogeology today bases on principles and approaches developed during this period. Parallel and almost immediately relevant for hydrogeology was then the introduction of tracer methods. Dye-tracers were applied to follow rainwater from its infiltration to points of discharge or were used to establish hydraulic connections between two points [2]. Such tracing methods are still being applied in very specific analyses of, for example, fracture systems in crystalline rocks investigated for waste disposal. Dye tracers also were the tool of choice to investigate the Austrian Alpine river network described here [2]. Tracer input in high altitude recharge areas was accompanied by monitoring throughout the drainage basin. This approach yielded very good results and greatly helped to understand flow paths and flow velocities of contributors to the surface runoff. This research intensified with the introduction of environmental isotope technologies. The water isotopes of hydrogen and oxygen permitted to characterize the recharge water and follow its path through the subsurface, where then primarily mixing of different components could be determined. From this, the first isotopic hydrograph separations resulted just 50 years ago – some earlier attempts using geochemical analyses were only partially successful. Where tritium analyses were available, these separations often permitted to add 'age dating' thus enhancing the understanding of the flow systems studied. The introduction of such 'simple' environmental isotope measurements to hydrogeology was rapidly followed by measurements of environmental isotopes in dissolved constituents, and within a short-time isotope analyses based on stable and radioactive isotopes became the dominating tool in river basin studies. This permitted not only direct and detailed hydrogeological observations


Model checking is considered a promising approach for the verification of software for embedded systems. Generating system models that are close to real-life behavior, however, is challenging. As a result, in some approaches a model can be automatically constructed out of the assembly code along with an appropriate target simulator/debugger. The implementation of the latter is crucial for the entire verification process. To that end, this paper presents requirements and challenges that arise when implementing and verifying such a simulator for the [mc]square model checker from the RWTH Aachen University.


Recurrent fish kills in the Spanish Alfacs Bay (NW Mediterranean) have been detected during winter seasons since 1994, and were attributed to an unarmored, ichthyotoxic, dinoflagellate, initially identified as Gyrodinium corsicum Paulmier, Berland, Billard, & Nezan. Several strains were isolated from the bay and their clonal cultures were compared by combined techniques, including light and electron microscopy, internal transcribed spacer and 5.8S rDNA nucleotide sequencing, and HPLC pigment analyses, together with studies of their photochemical performance, growth rates, and toxicity. Using phylogenetic analyses, all strains were identified as members of the genus Karlodinium, but they were separated into two genetically distinct groups. These groups, identified as Karlodinium veneficum (Ballantine) J. Larsen and K. armiger Bergholtz, Daugbjerg et. Moestrup, were also supported by the other techniques used. Detailed analyses of fine structural characteristics (including plug‐like structures in amphiesma and a possible layer of semi‐opaque material beneath the outer membrane) allowed discrimination of the mentioned two species. Specific differences in pigment patterns coincided with that expected for low‐ (K. veneficum) and high‐light (K. armiger) adapted relatives. The higher photosynthetic efficiency of K. veneficum and the longer reactivation times of the PSII reaction centers observed for K. armiger were in agreement with this hypothesis. The two species differed in toxicity, but the strains used always induced mortality when incubated with bivalves, rotifers, and finfish. Compared with K. armiger, strains of K. veneficum yielded higher cell densities, but had lower growth rates.


The vertical and rocking impedances of a rigid foundation resting on a semi-infinite transversely isotropic medium are obtained in the frequency domain. In the present approach, the contact pressure distribution on the soil foundation-interface is approximated by a linear combination of known pressure patterns. It is shown herein that the approximate solutions of spatial displacement distributions satisfy quite well the boundary conditions for this mixed boundary problem.


Objective To study the air microorganism contamination in tunnel,and to observe the disinfection effect of chlorine dioxide.Methods The total air bacterial and fungal counts were monitored before and after using chlorine dioxide by the method of knock-on and settling process.The effect of sterilization was evaluated.Results When sterilized in 10 mg/m3 for 30 minutes the dissolution ratio of total bacterial count was 94.6% by method of knock-on and 93.5% by method of settling process,while the dissolution ratio of fungal count was 92.1% by method of knock-on and 89.6% by method of settling process.When sterilized in 5 mg/m3 the dissolution ratios of total bacterial count and fungal were 69.5% and 73.3%.Conclusions The effectiveness of air disinfection in the tunnel is valid when use activated 1,000 mg/L chlorine dioxide in a final concentration of 10 ml/m3.


Objective To observe the effects of CF,5Fu and L-OHP on advanced colorectal cancer.Methods 46 patients with advanced colorectal cancer were randomly divided into two groups,including treatment group(n=32) and control group(n=14).Both groups were treated wiht CF and 5-Fu,in addition,the treatment group was additionally treated with L-OHP.After a course,the effects,toxic reactions and survival rate in one year of two groups were compared.Results The effective rate of two groups were significant difference(P0.05) and the toxic reactions of two groups were no significant difference(P0.05).1 year after treatment,The survival rate of treatment group was higher than those of control group.Conclusion The efficacy of CF,5-Fu and L-OHP on advanced colorectal cancer was affirmative.In addition,toxic reactions were lighter and tolerance well.


An adaptive predictive controller based on fuzzy neural model is proposed for the operation condition of the air-conditioning evaporator.The proposed adaptive predictive controller is mimics PID controller,therefore it possesses simply structure and can be easily operated.The evaporator is identified by fuzzy neural model,and then the parameters of the proposed controller are adjusted by gradient descent algorithm on line.The simulation results show that the proposed controller based on fuzzy neural model possesses better performance and can be used in evaporator of air-conditioning.


Seed classification contributes significantly to the final added value in crop production. Manual seed characteristics estimation is a difficult, time-consuming process that is prone to human error. Image processing is a good candidate for developing automated seed characteristics estimation systems. Many applications use image processing, such as inspecting pests in crop fields, grading fruits by size and color, estimating ripeness of fruits and vegetables before harvesting, and identifying crop diseases. For the classification of different seed varieties, old methods are still used. Manual seed size calculation and classification (small, medium, and large) with calipers, for example. There are no state-of-the-art methods for classifying seeds within species. This study will look at various image processing techniques for estimating various seed characteristics, improving classification, discovering new features, reducing complexity, and identifying flaws in existing techniques. According to the findings, there is a negative relationship between soya bean seed size and climatic factors. The decrease in osmotic ability affects larger seeds because they need more water for growth. As a result, seed selection is important prior to plantation based on environmental conditions.


Recruitment of the patent foramen ovale (PFO) while SCUBA diving has conventionally been thought to be caused by Valsalva maneuvers performed during ascent and may provide a route for venous air emboli to enter the arterial circulation. Alternatively, we hypothesized that mild increases in inspiratory and expiratory load, similar to that provided by a SCUBA regulator, would be sufficient to recruit the PFO. Two healthy adults with a PFO completed three randomized trials (inspiratory, expiratory, and combined (inspiratory/expiratory) loading) consisting of 6 levels of incrementally increasing load, to a maximum resistive load of 20 cmH2O/L/s. A saline contrast echocardiogram was performed at each resistive load to determine foramen ovale patency. Right atrial and pulmonary wedge pressures were obtained using a Swan Ganz catheter, and intrathoracic pressure was estimated using an esophageal balloon catheter. We found that PFO recruitment occurred in response to both inspiratory and expiratory loads. We will further examine the relationship between PFO recruitment, phase of the respiratory cycle, and the right‐to‐left atrial pressure difference during both loading conditions.


In biomedical trace element research, reference materials are a relatively recent development: indeed, Bowen's Kale Powder became available only in the middle of the 1960s, NBS Orchard Leaves (SRM 1571) and NBS Bovine Liver (SRM 1577) in the beginning of the 1970s. In general, when compared to a number of real samples submitted to laboratories for elemental analyses, these reference materials have high or relatively high trace element concentrations. This is probably best illustrated when the levels expected in human blood plasma or serum (matrices which are frequently analyzed both because of their established biomedical importance and their ready availability) are considered. For example, for chromium and manganese, figures are as follows-370 and 14,950 ng/g (in Bowen's Kale Powder), 88 and 10,300 ng/g (in NBS Bovine Liver), and 1.5 and 5.5 ng/g dry weight (in human blood plasma or serum). So, although the above-mentioned, first generation biological reference materials rendered excellent services as a means to check the accuracy and precision of analytical techniques, large numbers of investigators were still largely left to their own devices. Some reference materials are specifically aimed at researchers working on human blood plasma or serum, e.g., NBS Human Serum (SRM 909), Nycomed's Human Serum (STE 105), and National Institute for Environmental Studies' (NIES) (Japan) Freeze-Dried Human Serum. In all three cases, however, it is obvious that the original levels of several elements must have been drastically distorted during the collection and preparation of the


The purpose of this study was to identify the effect of muscular strength, sensation, and spasticity of the hip joint on balance using clinical tools in chronic stroke patients. Thirty-two subjects participated. It were measured muscular strength of the hip flexor, extensor, abductor, and adductor using manual muscle testing, light touch sensibility, and spasticity of the quadriceps using the modified Ashworth scale in the paretic lower extremity. Also, static and dynamic balance were measured by the functional balance scale. Collected data was analyzed by stepwise multiple regression. Muscular strength of the hip abductor, light touch sensibility, and spasticity were associated with static balance(p


only to 1968. State space provides the unifying framework that the authors need. There are many parametrizations in state space that are equivalent in practice if infinite precision is available. When the parameters are implemented with FWL, however, the roundoff errors destroy this equivalence and lead to different degrees of performance degradation. It is then natural to formulate a range of optimal parametrization problems where optimality refers to objectives such as minimising the sensitivity of a filter transfer function with respect to parameter errors. Within the state space-sensitivity-optimisation framework the authors comprehensively survey the literature, pose, solve and discuss a number of FWL problems and illustrate the solutions with suitable examples that are illuminating for those working in the areas of signal processing, control and adaptive systems. Despite the need for a considerable amount of matrix manipulation, we are never allowed to lose sight of the connections to final practical goals. I found the material on delta operator v shift operator methods in estimation and control particularly interesting, throwing light on the links between these approaches, data prefiltering in identification and FWL problems. It is a long time since I have read a book that has such a degree of novelty yet accessibility. It set me thinking about all sorts of related sensitivity problems and this stimulus and buzz is surely what a reader looks for in any book. Excellent!


Using the northern Asian Salticidae as an example, it is shown that the faunistic suture zones, where ranges of allopatric species meet or overlap, can be used as 'indicators' of biogeographical boundaries. In northern Asia 16 pairs of allopatric species, divided into 5 groups, characterise the area defined earlier as the Angaran subregion. Additionally 18 endemic/subendemic species (15 % of all northern Asian salticids) are found there. By analysing the habitat preferences of Siberian endemics, it is assumed that they may be traced either to mountain forest-steppe or mountain tundra landscapes, and seem to be of late Pleistocene/Holocene origin.


This paper analyzed the characteristics of electric arc furnace of yellow phosphorus production.It takes Human-Simulated Intelligent Algorithm as the complexity of smelt process.Input Energy according to the best power curve.The coupling between three-phase electrodes was considered in particular,and also the treatment of abnormal condition is included.The performance of this control system is pretty as it ran more than one year.


The Advanced Light Source (ALS) storage ring has a 4.9 meter magnetic radius and an antechamber type vacuum chamber. These two requirements makes conventional bent tube manufacturing techniques difficult. The ALS sector vacuum chambers have been made by machining two halves out of aluminum plate and welding at the mid plane. Each of these chambers have over 50 penetrations with metal sealed flanges and seven metal sealed poppet valves which use the chamber wall as the valve seat. The sector chambers are 10 meters long and some features in the chambers must be located to .25 mm. This paper describes how and how successfully these features have been achieved.


The molecule of the title compound (C 5 H 4 N 2 O 4 ) is practically planar; the dihedral angles between the ring plane and the planes of the nitro group and the aldoxime group are 5.0(3) and 4.4(3)°, respectively. Intermolecular O4-H4...N2 hydrogen bonds, with O-H = 0.96 (5), H...N = 1.89 (5), N...O = 2.827 (5) A and O-H...N = 164(1)°, connect molecules into infinite chains along the b axis.


Introduction: Essential hypertension is an important public challenge having leading positions in morbidity and mortality worldwide. Co-morbid hypertension and obesity is a multifactorial disorder, but mechanisms leading to weight gain in hypertensive persons are not completely known until now. According to data of our recent observations and literature, apelin is believed to play an important role in development of obesity in hypertension. Aim: The aim of the study was to investigate apelin-12 level changes in Ukraine patients with essential hypertension and obesity. Materials and methods: Ninety-six patients with essential hypertension were examined. Surveys, examinations and laboratory investigations were conducted according to internationally accepted protocols. In all patients levels of apelin-12 and glucose in blood were assessed. Also systolic and diastolic blood pressures were measured, and Body Mass Index scores were calsulated in all subjects. All patients were categorized by means of k-means clustering using apelin and Body Mass Index means. Difference between groups was calculated using Kruskal-Wallis test. Results: Patients were categorized into 4 cluster based on k-means according to apelin and Body Mass Index scores. The 1st and 2nd clusters had opposite meanings of Body Mass Index scores. Patients of the 1st cluster had the lowest Body Mass Index scores and also the shortest duration of the disease. No significant differences of Body Mass Index scores in patients of 3rd and 4th clusters were detected, but the opposite apelin activity was detected. In cluster 4, adipokine activity was the lowest in total group of patients, and in cluster 3 – the highest. Patients of 4th cluster had pronounced carbohydrate disorders and dyslipidemia. Significant correlations of apelin with parameters of carbohydrate pool were found. Summary: The increased level of peptide apelin in hypertensive patients was detected. Significant dyslipidemia with high atherogenetic index, dysglicemia, hyperinsulinemia, and pronounced expression of pro-inflammatory cytokines are accompanied with decreased apelin level and negative correlation of Body Mass Index with peptide. Overexpression of apelin in hypertensive patients with moderate abnormalities in lipid and carbohydrate metabolism is considered as a compensatory reaction. keywordS: essential hypertension, obesity, adipokines. AddreSS for correSpoNdeNce: Kharkiv National Medical University Prospekt Lenina 4, 61022, Kharkov, Ukraine Tel.: (+057) 7323344 E-mail: email@example.com burden of disease in the world. [Haslam D., James W., 2005]. Obesity itself is recognized as one of the most important risk factors for the development of hypertension and its progression. Hypertension in obese patients in over 60% is associated with gluco-metabolic disturbances, like insulin resistance, glucose intolerance. Moreover, diabetes develops in 2% of treated hypertensive patients every year [Demydenko G., Kovalyova O., 2013]. Carbohydrate metabolism plays a central role Received 04/22/2014; accepted for printing 10/21/2014


Three different laying stage quails have been studied in this research.Supplementation of daidzein(Da,at the dose of 3 mg/kg) greatly increased the laying rate and serum T 3 level of 35 day old quails by 6 9%(P0 05) and 22 8% (P0 05),respectively.Laying qualils(7 months of age) fed diet containing 3 mg/kg of Da showed obviously higher laying rate (P0 05) and T 3 level (P0 05),while those treated with Da at the dose of 6 mg/kg showed a decrease of laying rate(P0 05).Moreover,the laying rate of quails(12 months of age) fed diet containing 6 mg/kg of Da was apparently increased(P0 01).Serum T 3,T 4 and IGF 1 elevated by 34 8%(P0 01),27 6%(P0 05) and 30 8%(P0 05),respectively.These results indicate that optimum concentration of Da can significantly promote laying rate of different laying stage quails.


Transplants are produced and sold in South Africa for the planting of seedcane supply plots (nurseries), commercial fields, and for gap filling. The most important factor constraining the use of transplants is the low germination of single-budded setts (SBS) planted in polystyrene trays. The main aims of this project were to develop practical methods for optimising germination and to control pathogens without adversely affecting germination. Seedcane quality, cane age, storage and treatments using heat, chemicals and fungicides affected germination and growth. Germination of SBS from old seedcane was significantly higher when taken from the top than from the middle and bottom of the stalk. Storage of seedcane for three and eight days after harvest adversely affected germination and growth. Topping of stalks three days before harvest increased germination potential, but results were variable, depending on cane age, cane quality and further treatments. Treatment of SBS at both 50°C for 120 minutes and 52°C for 30 minutes controlled Clavibacter xyli subsp. xyli (C. x. xyli) (the causal organism of ratoon stunting disease) more effectively than treatment of whole setts. After treatment of SBS at 52°C for 30 minutes, germination was greater than that after treatment at 50°C for 120 minutes, and C. x. xyli was eliminated from stalks of six out of seven varieties. Treatment of SBS at 52°C for 10 minutes significantly improved both germination and plant growth. Treatment of SBS for 10 minutes after addition of ethephon to the hot water significantly increased germination compared with the untreated control, but not compared with treatment with hot water alone. After treatment of SBS with fungicides, germination was highest after treatment with Eria® (Novartis), a chemical with two active ingredients, namely carbendazim and difenoconazole. Compared with no treatment and the short hot water treatment, treatment with Eria® in hot water (52°C) significantly improved germination and plant growth in both unsterilised and sterilised medium. Treatment of SBS and drenching of trays with a solution of propamocarb-HCl and benomyl had no effect on germination or growth, indicating the limited role of systemic infections and soilborne pathogens in germination failure. However, germination and growth were significantly increased


Activation of T cells is thought to play an increasingly important role in the pathogenesis of inflammation and insulin resistance in obesity and Type 2 diabetes. Costimulation is essential for amplification of the T cell response, with the co-stimulatory molecules CD80 and CD86 playing an important role in the pathogenesis of a variety of inflammatory diseases. In this study, we used CD80/CD86 double knockout (B7 KO) mice to investigate the involvement of these key molecules in diet-induced obesity (DIO) and insulin resistance. Wild-type (WT) and B7 KO mice were fed either high fat diet (HFD) or normal chow. After 12 weeks of HFD feeding, WT and B7 KO mice had similar weight gain. B7 KO mice had less epidydymal fat (1.31±0.04 g vs. 0.92±0.06 g for WT vs. B7 KO) which was confirmed by MRI measures. Despite less systemic T cell activation, insulin resistance was significantly worse in the B7 KO mice. B7 KO mice had decreased Treg content which was a result of both impaired development and proliferation. A defect in Treg cells conferred enhanced classical activation of macrophages in the adipose tissue. Adoptive transfer of Treg into B7 KO mice restored insulin sensitivity in B7 KO mice on HFD. Taken together, lack of B7-mediated costimulation results in impaired development and proliferation of Treg and enhanced adipose inflammation and insulin resistance. Our results suggest an essential role for B7 in maintaining Treg numbers in experimental DIO.


Teaching method with cases includes theory,cases,and operation.The procedure of the teaching,generally,divides into five stages,such as following,thinking,creative,mixed and consolidated study,etchence to broaden the teaching space of it and cultivate students' ability to solve problems.


In order to promote the development of mass sports movements such as: material foundations, funding sources, and synchronous promotion at all levels in the District to create conditions to thoroughly grasp the activities of developing Physical Fitness. Mass sports. Co-application of solutions, including creating human resources to work in mass physical training and sports activities in Tay Son and Binh Dinh districts: Conisistent with the development strategy of the Province and the City Party Committee.


Abstract. An idea used in the characterization of even perfect numbers is used, first, to derive new necessary conditions for the existence of an odd perfect number and, second, to show that there are no even 3-perfect numbers of the form , where M is odd and squarefree and , besides the six known examples.


The orthogonal frequency division multiplexing(OFDM) has been regarded as the core technology of 4G wireless communications system in the future,but the problem of high peak-to-average power ratio(PAPR) is the main obstacle to limit the applications of OFDM.A novel concurrent selective mapping(SLM) algorithm is thus proposed to reduce the PAPR in space-time block coded(STBC) MIMO-OFDM systems.It is proved that the conjugate symbols of two antennas have the same PAPR property,which results in that PAPR reduction to be done is only for the first symbol period.By using the property in the proposed algorithm,the cost due to computational complexity is significantly reduced with the same PAPR performance kept in comparison with the conventional concurrent SLM algorithm.Simulation results demonstrated that the performance of the proposed algorithm outperforms the conventional concurrent SLM algorithm.


Purpose: The purpose of this study was to correlate treatment response with tumor blood perfusion in patient of advanced head-and-neck cancer undergoing neoadjuvant chemotherapy. Materials and Methods: A total of 40 patients of advanced head-and-neck cancer, who were planned for neoadjuvant chemotherapy, were included in the study. All patients underwent diagnostic computed tomography (CT) with perfusion study for staging and quantitative measurement of tumor volume as well as perfusion parameters (including tumor blood volume, blood flow, permeability, and time to peak enhancement), at baseline and after completion of neoadjuvant chemotherapy. Total 3 cycles of neoadjuvant chemotherapy with paclitaxel, cisplatin, and 5 fluorouracil were given. Tumor response was evaluated in terms of change in tumor volume and correlated with perfusion parameters. Results: Out of 40 patients, 22 patients had more than 50% reduction in tumor volume, who were grouped as responder and remaining 18 patients had <50% decrease in tumor volume, grouped as nonresponder. Both the groups were similar in terms of age, gender, performance status, stage, nodal status, or addiction. Baseline CT scan shows a significant difference in tumor blood flow (P = 0.048) and marginal difference in time to peak enhancement (P = 0.058) in two groups. However, there is no difference in tumor blood volume (P = 0.32) and permeability surface area (P = 0.07). Conclusions: Evaluation of tumor blood flow by perfusion CT is helpful in predicting chemotherapy outcome and deciding appropriate treatment modality, but further evaluation with more number of patients is required for validating the predictive role of each perfusion parameters.


Machining parameters in turning processes including cutting speed, depth of cut, feed rate, and the length of the cutting parameters affect the product quality. One of the required product quality is the level of surface roughness. Reseach used response surface experimental based on central composite design to develop the empirical method of relationship between cutting parameters and surface roughness. Furthermore, an optimization is also conducted by using desirability function approach to determine the combination of cutting parameters in order to have low surface roughness of product. The results show that the machining parameters (depth of cut, length of cutting, cutting speed) have significant impact to the surface roughness of product. Based on the results, the mathematical model: Y = 1.109 -0.068(X ) – 0.111(X 2 )-0.098(X 3 ) + 0.268 (X 1 ) 2 + 0.17 (X 2 ) 2 + 0.106 (X 3 ) 2 + 0.086X 1 X 2 - 0.073X Keywords: surface roughness, machining, depth of cut, cutting speed.


Multimedia streaming is growing at a phenomenal rate, especially with the emergence of augmented/virtual reality applications and the growing demand for YouTube-like services. This stimulates research in all aspects of streaming systems, including but not limited to real-time and resource-efficient transcoding, server efficiency, network optimization, and client adaptation. Research and development of any part of the system require repetitive and tedious tasks in setting up the rest of the system for validation and evaluation of new ideas. This not only complicates the research work but also challenges the reproducibility and sharing of the research results. Existing proposed testbeds all have a specific focus and do not address all components of multimedia streaming. In this paper, we propose iStream, a flexible testbed for multimedia streaming system that integrates various components relevant to such systems. The components are plug-&-playable and customizable to compose various streaming systems and setups. iStream provides multimedia system researchers and developers with a flexible playground to explore their innovative ideas. Along with the design, we present a diverse set of case studies demonstrating the wide-range use of iStream.


This document explores the inclusion of transient analysis in the optimization of water distribution systems. Fluid transients, also referred to as water hammer, play a significant role in determining the design criteria for a distribution system and optimization procedures should account for their presence. The inclusion of transient analysis in an optimization process can be achieved through the use of an enumeration process that utilizes a simulation framework. A complete enumeration scheme that incorporates both transient and steady state concerns is developed. This comprehensive optimization approach is explored through a case study involving a simple pipeline connecting a pump and a storage reservoir. The entire solution space for the system under consideration in the case study was determined and the global optimum was identified. A design that accounts for the effects of a pump-trip was achieved at a marginal cost over the optimal steady state design which would have been at considerable risk of failure if a pump-trip were to occur. A method that reduces the simulation burden or workload without constraining the solution space was developed and applied to same the case study. This technique referred to as the Probabilistic Selective Simulation (PSS) method randomly selects designs for simulation from the complete population of design alternatives for simulation. The success of the method varied according to the desired fraction of designs to be selected. The PSS method produced designs that ranged from 0.2% to 0.8% more expensive than the global optimum for selection targets of 10% and 1% respectively. These results can be viewed as successful when the reductions in the execution time relative to the full enumeration are considered.


Focusing on the "Meng",there are different explanations of "Fu-guan" in Meng,Wei Feng,The Book of Songs in successive dynasties.Considering the marital customs at that time,"Fu-guan" should be an insinuation,which means "returning matchmaker".In the Spring and Autumn Period,the marriage of commoners was decided by the command of parents and words of a go-between.It has both special backgrounds and progressive meanings at that time.The basic structure of the commoners' marriage is "Three Ceremonies".


A CMOS image sensor with stacked photodiodes was fabricated using 0.18 µm mixed signal CMOS process technology. Two photodiodes were stacked at the same position of each pixel of the CMOS image sensor. The stacked photodiodes consist of shallow high-concentration N-type layer (N+), P-type well (PW), deep N-type well (DNW), and P-type substrate (P-sub). PW and P-sub were shorted to ground. By monitoring the voltage of N+ and DNW individually, we can observe two monochromatic colors simultaneously without using any color filters. The CMOS image sensor is suitable for fluorescence imaging, especially contact imaging such as a lensless observation system of digital enzyme-linked immunosorbent assay (ELISA). Since the fluorescence increases with time in digital ELISA, it is possible to observe fluorescence accurately by calculating the difference from the initial relation between the pixel values for both photodiodes.


The interest of coumarins as antioxidant agents has attracted much attention in recent years. A quantitative structure-activity relationship (QSAR) study of the DPPH• (2,2-diphenyl-l- picrylhydrazyl) radical scavenging ability of chemical compounds, based on the 0-3D DRAGON molecular descriptors and an artificial neural networks (ANN) technique was developed. The built mathematical model showed a correlation coefficient for the training set (R 2 ) = 0.71, an external correlation coefficient (�� ������ 2 ) = 0.65 and it was used to predict the antioxidant activity of 4-hydroxycoumarin derivatives. Besides, an experimental in vitro assay was developed for the reference compound of this group (4-hydroxycoumarin) and the results obtained confirmed the predictions made by the ANN.


What should we teach to the designers of the future so they can embrace
complexity by developing forms that are creative and human, and consider the
different aspects of life in a changing world? What are the specific learning
outcomes that should be formulated in the planning of a design curriculum?
What are the most important design competencies that should be considered in
this process? How would design competencies add value to design education? In
this paper, we intend to study the value of design competencies within an
Outcomes-Based Education (OBE) curriculum framework by understanding the
interconnections between design competencies and their related learning
outcomes. In this order, we first determine design competencies and subcompetencies
as "the proven abilities to use knowledge, skills and personal,
social and/or methodological abilities, in work or study situations and in
professional and personal development" (Savic & Kashef 2013, p. 990). Then we
revisit the definition of design as a profession in the 21st century by a
comparative analysis of designers' perception of their own knowledge, skills and
attitudes acquired through their education and applied within their design
practice. Finally, we will discuss a new model of design competencies, which
would enable educators to articulate practice-based learning outcomes that will
in turn enhance the value of design education in the new era.


Investment Incentive Agreement between the Government of the United States of America and the Government of the Republic of Armenia. Washington, 2 April 1992


The saga of the Edinburgh Trams, and ensuing Public Inquiry, sheds light on systems of power and influence in the city. Drawing mainly upon Inquiry evidence, this article gives an account of why the project was over-budget, curtailed in length, and failed to meet the original timetable. It examines how blame was apportioned by key actors. In terms of analysis, the article explores the Trams as a 'mega-project', and locates it in the context of outsourcing the state, both national and local. More generally, it treats Edinburgh as an example of the 'calculable city', in which assets are treated as future forms of revenue rather than as public resources.


The aim of the present study was to provide aerobic (maximal oxygen consumption – VO2max) and anaerobic [jump tests: counter-movement jump (CMJ) and bounce jump (BJ); and running tests: 10 m sprint and 10 m dribbling the ball (10 mDB)] profiles of older soccer players (n = 12), and heart rate (HR), blood lactate accumulation (La) and match analysis (individual motor activity and team behaviour) aspects of a soccer match. The maximal aerobic test values were: HRmax, 154 ± 14 beat min−1; maximal power, 160 ± 24 W; VO2peak, 36.3 ± 11.3 ml kg−1 min−1; peak La, 8.2 ± 1.8 mM. Jump test values were: CMJ, 21.2 ± 4.5 cm; BJ, 17.3 ± 4.8 cm. Running performances were: 10 m sprint, 2.06 ± 0.36 s; 10 mDB, 2.17 ± 0.21 s. Running showed similar values in the two halves (first half, 82%; second half, 88%), while walking lasted longer during the second half. Regarding the technical aspects of the match, 42% of the consecutive passes made in possession of the ball exceeded three passes, indicating that their play was structured in a cooperative manner. Older soccer players succeeded in maintaining good aerobic and anaerobic physical capability.


1. An idea without a future 2. The hollow men 3. The dream and the fetish 4. The protocol of (re) writing 5. A man of the last hour 6. A postscript of transgression Notes Index.


Telescoped ground engaging telescoped wear and support members are provided with self-adjusting connector apparatus that releasably retains the wear member in a rearwardly telescoped orientation on the support member. In illustrated embodiments thereof, the connector apparatus includes cooperating ratchet structures operatively associated with the support and wear members and functioning to automatically re-tighten an abrasion-created loosened interfit between the wear and support members in response to a rearwardly directed operational force imposed on the wear member.


Cerebral ischemia-reperfusion (CIR) seriously affects human health and life as it is accompanied by inflammation and apoptosis in brain tissues. Tubeimoside I (TBMS-1) can inhibit neuroinflammation and has neuroprotective effects; however, its effects on ischemia-reperfusion (IR) injury of the brain requires clarity. A mouse cerebral artery occlusion/reperfusion model was used to simulate CIR injury. The neurological function and the area of cerebral infarction were assessed by 2,3,5-triphenyltetrazolium chloride staining. Tumor necrosis factor-α, Interleukin (IL)-1β, IL-6, and IL-10 levels were measured by enzyme-linked-immunosorbent serologic assay kits. Protein blot analysis was performed to assess the expression of apoptosis-related factors. In addition, PC12 (pheo-chromocytoma) cells were treated with oxygen–glucose deprivation/reoxygenation (OGD/R) to establish an in vitro model of CIR injury. The cell viability was measured by cell counting kit-8 assay, and apoptosis levels were detected by flow cytometry. In vivo results indicated that Tubeimoside I reduced cerebral infarct size, decreased inflammatory factor content, inhibited the expression of apoptosis-related factors, including Bax and cleaved-caspase-3 (Asp175), and promoted the expression of survival factor, such as B-cell lymphoma protein 2. In vitro, Tubeimoside I was able to increase cell viability and inhibit apoptosis. Mechanistically, Tubeimoside I was able to enhance both in vivo and in vitro expressions of NAD-dependent deacetylase sirtuin-3 (SIRT3). SIRT3 inhibitor abolished the protective effect of Tubeimoside I on OGD/R-treated cells. Tubeimoside I lessened CIR injury by activating SIRT3. Hence, it could be a potential drug candidate for treating IR injury of the brain.


To associate Baudelaire and Barthes may seem a somewhat unlikely gesture. Barthes wrote about Baudelaire in a sustained way only once and with reference to a marginal part of the poet's work, namely his failed theatrical projects. Yet Baudelaire remains a point of reference across
 the entire span of Barthes's career, in particular as the author of a frequently cited quotation from 'Exposition Universelle' (1855): 'la vérité emphatique du geste dans les grandes circonstances de la vie'. This phrase punctuates Barthes's
 published work throughout, from one of his earliest essays to his very last book on photography, and is closely associated with another persistently recurring motif: the concept of numen, a term used to designate a static gesture expressing divine authority. The aim of this article
 is to examine the significance of Baudelaire for Barthes by investigating how he deploys the quotation from the 'Exposition Universelle' essay and the intertwined concept of numen. Its guiding questions are: what does Baudelaire mean for Barthes? And what does that tell
 us in turn about Baudelaire? Answering these questions involves tracing the intersecting trajectories of quotation and concept across Barthes's work, with a particular focus on the value to be attributed to exaggeration or excess in the communication of meaning through gesture and language,
 a phenomenon that both Barthes and Baudelaire associate with hysteria, as either something to be ironically assumed (Baudelaire) or ambivalently exorcized (Barthes).


Small special libraries in Hungary using the Tinlib system have sought solutions, within the frame of two TEMPUS grants, for the DOS-based catalogue service on the Internet. The first grant is used to link the catalogues of both libraries to the Kozelkat system. The second grant helps to install a common server under the auspieces of the Tinlib user service. The main phases of the project are: (1) Both libraries convert and upload their catalogues to the databases inplemented on the common server that are available on the Internet and updated continously. (2) The databases will be searchable on multiple surfaces, in simple Web form and in more complex forms. (3) The catalogues will be linked in reasonable groups to the Kozelkat system. (4) A common system will be created for storing the libraries' full-text and multimedia documents.