The adoptive transfer of T cells gene-targeted with chimeric antigen receptors (CARs) has emerged as an exciting cancer immunotherapy due to the induction of complete remissions (CRs) in patients with chemotherapy-refractory hematologic malignancies. The CAR is an antigen-receptor created by fusion of the antigen-receptor domain of an antibody to the activation and co-stimulatory proteins associated with the T cell receptor (TCR) complex (reviewed in [1–3]). The CAR class most commonly investigated in clinical trials, CD19-targeted CAR T cells, will be considered for US Food and Drug Administration (FDA) approval as a standard of care for patients with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL) and diffuse large B cell lymphoma (DLBCL) in 2017 [4–9]. Such a paradigm-shifting and novel cancer therapy that relies on viral production, geneticmodification, cell expansion, quality control/quality analysis, as well as clinical application and toxicity management poses significant challenges to regulatory oversight. Institutional and federal regulatory management of CAR T cell clinical trials has proven adept at evaluating safety implications for patients. In 2016, there were at least 10 active clinical trials in the United States evaluating virally-modified CD19-targeted CAR T cell for B cell malignancies [10]. With impending approval for CD19-targeted CAR T cells, the challenges facing regulatory oversight of these products post-approval will be highlighted. The experiences with CD19-targetd CAR T cells will also serve as a valuable model to be used for cell therapies in future years.


In Sweden, the current national deficit is putting immense pressure on all government spending. Economic recession and increased levels of unemployment have jointly altered the image of the welfare state and redirected focus on it as a financial burden. A matter of considerable political and public concern is the consequences of the economic constraints on social services - the part of the welfare programs carried out by local authorities. This article raises concerns of resource allocation, starting from an outline of the impact of economic developments on different sectors of the social services. Expenditure for elderly care, child care and individual and family care is analyzed in the light of demographic changes and coverage rates. A main focus is put on the most recent development and the perceivable strategies for managing the financial cut-backs are discussed in detail. Two strategies stand out as central. One is dilution, which is granting help to an unchanged number or proportion of people granted help, combined with a decreased level or altered quality of the service provided. The other is focusing, where eligibility is defined more narrowly and in the normal case results in a consistent or even improved level of service to the most needy. Dilution seems to be the major strategy for child care and focusing the allocative trend in services for elderly people.


Background: This study sought to investigate the prognostic impact of right atrial (RA) size and function in patients with heart failure with preserved ejection fraction (HFpEF) in sinus rhythm (SR) and atrial fibrillation (AF). Methods: Consecutive HFpEF patients were enrolled and indexed RA volumes and emptying fractions (RA-EF) were assessed by cardiac magnetic resonance imaging (CMR). For patients in SR, feature tracking of the RA wall was performed during CMR. In addition, all patients underwent right and left heart catheterization and 6 min walk distance (6MWD) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) evaluations. We prospectively followed patients and used Cox regression models to determine the association of RA size and function with a composite endpoint of heart failure hospitalization and cardiovascular death. Results: A total of 188 patients (71% female patients, 70 ± 8 years old) were included. Ninety-two patients (49%) were in persistent AF. Eighty-five patients reached the combined endpoint during a follow-up of 69 (42–97) months. After a multivariate cox regression analysis, the impaired RA reservoir strain (HR 0.949; 95% CI [0.909–0.990], p = 0.016), the RA reservoir strain rate (HR 0.991; 95% CI [0.983–0.999], p = 0.028), the RA conduit strain (HR 0.932; 95% CI [0.879–0.988], p = 0.019), and the RA conduit strain rate (HR 0.989; 95% CI [0.881–0.997], p = 0.011) were significantly associated with a worse outcome for patients in SR. In persistent AF, no RA imaging parameter was related to outcome after a multivariate regression analysis. Conclusions: In HFpEF patients in SR, CMR parameters of impaired RA conduit and reservoir function are associated with dismal cardiovascular outcomes. In persistent AF, RA parameters lose their prognostic ability.


Summary High throughput sequencing technologies have enabled cross-species comparative transcriptomic studies; however, there are numerous challenges for these studies due to biological and technical factors. We developed CoSIA (Cross-Species Investigation and Analysis), an Bioconductor R package and Shiny app that provides an alternative framework for cross-species transcriptomic comparison of non-diseased wild-type RNA sequencing gene expression data from Bgee across tissues and species (human, mouse, rat, zebrafish, fly, and nematode) through visualization of variability, diversity, and specificity metrics. Availability and Implementation https://github.com/lasseignelab/CoSIA Contact Brittany Lasseigne (firstname.lastname@example.com) Supplementary information See Supplementary Files


Abstract The object of the present paper is to investigate the coefficients estimates, distortion properties, the radii of starlikeness and convexity, subordination theorems, partial sums and integral mean inequalities for classes of functions with two fixed points. Some remarks depicting consequences of the main results are also mentioned.


This study features a content analysis of the Greek primary school social studies curriculum of two consecutive educational reforms—those of 1982 and of 2000—both of which are used in schools today. The purpose of the study is to determine if there are global themes in the curricula of both reforms, and to compare which of the reforms includes the most references regarding global themes. The analysis revealed that even though the majority of references address national orientations, both of the reforms contain references to global themes; however, the 1982 reform has more references than that of the year 2000. It is recommended that countries in the European Union and beyond revisit their curricula in order to enhance global orientations and international perspectives, especially in the area of social studies, so that students are better able to make the leap from being national citizens to becoming 'cosmo-citizens'. Conceptualizing globalization and global education lobalization has recently received a great deal of emphasis even though remarkable attention to international matters has been given after World War II. Various recent developments, however, have brought about a new consciousness that individuals, nations, and societies constitute an integral part of the planet. Such developments include: universalization of education, realization that humanity lives on a single planet Earth and that we all constitute an extended family, concern about the ecology of the planet, tremendous development in information and communication technologies, the advent of 'global village' and the fact that there has been a world wide growth of economic, political, cultural, technological, and ecological systems (Billeh, 1999; Flouris, 2001). Globalization means different things to different groups of people depending on whether they are governmental officials, business leaders, teachers, unemployed groups, human rights activists, environmentalists, and so on. Different groups view globalization as good or bad, positive or negative, a form of exploitation or freedom. Thus, values are key to assessing the impact of globalization on people, cultures and societies. Among the varieties of definitions G


Abstract Hydrophobic silica aerogels (SiO2(AG)) was prepared via sol-gel and solvent exchange method under ambient pressure, which could be transformed to hydrophilic after heated under 500∘C. Heat treatment cannot change its structure. SiO2(AG) samples were the micro-porous structure formed by numerous fine particles and had high specific surface area, pore size and pore volume. The absorption performance of hydrophobic/hydrophilic SiO2(AG) on nitrobenzene, phenol and methylene blue (MB) showed that hydrophobic SiO2(AG) exhibited strong adsorption capacity on slightly soluble organic compounds, while hydrophilic SiO2(AG) was much more effective on adsorbing soluble compounds, which could be analyzed by the hydrophobic and hydrophilic interaction theory between the adsorbent and adsorbate.Hydrophobic/hydrophilic SiO2(AG) adsorption performance for MB is superior to that for phenol, which could be explained via the electrostatic interaction theory.


Delivery of appropriate levels of resource utilization is the key to controlling costs in today's health care settings. Nurse Managers have a strategic and pivotal role in patient care delivery and health-care organizations, and have become more accountable for managing patient care, personnel and costs in the face of fluctuating patient activity. The most frequently used statistic for the measurement of nursing care and personnel staffing is Nursing Hours Per Patient Day (NHPPD). The purpose of the development of a PC-based spreadsheet was to provide the nurse managers with an easy-to-use, interactive tool from which changes in resource needs could be quickly determined from changes in patient volume and activity.


Dimensionality-reduction methods are a fundamental tool in the analysis of large datasets. These algorithms work on the assumption that the "intrinsic dimension" of the data is generally much smaller than the ambient dimension in which it is collected. Alongside their usual purpose of mapping data into a smaller-dimensional space with minimal information loss, dimensionality-reduction techniques implicitly or explicitly provide information about the dimension of the dataset.In this paper, we propose a new statistic that we call the kappa-profile for analysis of large datasets. The kappa-profile arises from a dimensionality-reduction optimization problem: namely that of finding a projection that optimally preserves the secants between points in the dataset. From this optimal projection we extract kappa, the norm of the shortest projected secant from among the set of all normalized secants. This kappa can be computed for any dimension k; thus the tuple of kappa values (indexed by dimension) becomes a kappa-profile. Algorithms such as the Secant-Avoidance Projection algorithm and the Hierarchical Secant-Avoidance Projection algorithm provide a computationally feasible means of estimating the kappa-profile for large datasets, and thus a method of understanding and monitoring their behavior. As we demonstrate in this paper, the kappa-profile serves as a useful statistic in several representative settings: weather data, soundscape data, and dynamical systems data.


Abstract : This report documents the results of an Air Force Research laboratory in house program entitled Advanced Displays and Intelligent Interfaces (ADII). Specifically, it details how the technology that was developed and integrated within the ADII program was applied to showcase how it could be used in military and commercial environments. The two main capabilities within the ADII program that are addressed are the interactive datawall and the virtual worlds environment. Specific applications, as well as future plans for both capabilities, are discussed.


In order to investigate the role of urban sculpture in shaping the sense of identity in contemporary urbanism, studying their history and background and reasons for their emergence in the city seem to be necessary. The emergence of the identity crisis may be a predisposing factor for authentication attempts. Location is an aspect of space which is occupied by something or someone and has meaning and value dimensions. In other words, location is where function and meaning of space interact. Thus, form, function, installation place and connotation of urban sculpture can have a central role for formation and alignment of existent semantic identity of urban planning of a city. The goal of this study is to study the role of these statues in the sense of identity in urban planning and the research method was literature review and surveying. The results show that the statues have a major role to stabilize or disrupt the meaning of identity in a city.


From April to November 2004 was made a bat fauna inventory in Northern of Mato Grosso do Sul, Brazil (Jauru's Project/MMA). Eight points was sampled with mist-nets in a cerrado's ecosystem and was caught 146 individuals de 28 species, distributed into six bat families. The total of species in this study just represents 30% of cerrado's bat fauna. The more caught family was Phyllostomidae represented by Glossophaga soricina (Pallas, 1766) and Artibeus lituratus (Olfers, 1818). Some rare species were caught: Lophostoma brasiliense (Peters, 1866), Lonchophylla mordax Thomas, 1903 and Lionycteris spurrelli Thomas, 1913. The more abundant point sampled (0.032 bat/m2/h) shown a Simpson index of D = 3.86 and the low abundant point sampled (0.003 bat/m2/h) was D = 3.03. The preservation of water springs and forest cover in study sites are discussed.


Amorphous calcium phosphate (ACP) attracts attention as a precursor of crystalline calcium phosphates (CaPs) formation in vitro and in vivo as well as due to its excellent biological properties. Its formation can be considered to be an aggregation process. Although aggregation of ACP is of interest for both gaining a fundamental understanding of biominerals formation and in the synthesis of novel materials, it has still not been investigated in detail. In this work, the ACP aggregation was followed by two widely applied techniques suitable for following nanoparticles aggregation in general: dynamic light scattering (DLS) and laser diffraction (LD). In addition, the ACP formation was followed by potentiometric measurements and formed precipitates were characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), and atomic force microscopy (AFM). The results showed that aggregation of ACP particles is a process which from the earliest stages simultaneously takes place at wide length scales, from nanometers to micrometers, leading to a highly polydisperse precipitation system, with polydispersity and vol. % of larger aggregates increasing with concentration. Obtained results provide insight into developing a way of regulating ACP and consequently CaP formation by controlling aggregation on the scale of interest.


patent is extknded or adjusted under 35 U.S.C. 154(b) by 0 days. pre-alteration the use of a marker, state) the aqueous barrier. the impact on the blood brain


This paper describes a collaborative application of the Community Health Assessment Sustainability Education (CHASE) model (Ross, Crawley & Mahoney, 2017) to rural community development. The rural population nationally and internationally accounts for almost half of the total global population and these communities are confronted with reduced access to healthcare which contributes to increased health disparities (Couper et al., 2015; Hogarth & Rapata-Hanning, 2015). Nurses play a critical role in reducing these disparities around the globe with limited models to guide their practice (Ross & Crawley, 2018; Doolan-Noble, 2019). While nurses are positioned to navigate the holistic landscapes of health that integrate the socio-political, cultural, sustainable, economic and environmental aspects related to the uniqueness of rural communities they, require models to guide their practice. The CHASE model is one such model that guides practice however, we are aware one such model does not fit all communities therefore, the purpose of this research is to revise how this model is used and adapted for ongoing and future application.


This study aims to determine how the drive thru service system affects the compliance of taxpayers of two-wheeled motor vehicles in Banyuwangi City. This research is designed by suing qualitative approach. The data in this study was collected through data collection techniques, namely observations to the research site directly, distributing questionnaires, and collecting documentation. This study uses cross tabulation analysis assistance, then only measures two variables namely the drive thru service system (variable x) and taxpayer compliance (variable y). The results show that the taxpayer compliance of two-wheeled motor vehicles, obtained a point of contact in the high category of 23 people or 95.83%, and in the category of being found as many as 1 person or 4.17%. From the results, it can be concluded that the drive thru service system has a relationship to the taxpayer compliance of two-wheeled motor vehicles to complete their obligations in paying tax on two-wheeled motor vehicles. But in the service of drive thru samsat, it is felt that there are still some obstacles, among others, online networks from the center that sometimes experience problems, the operational duration of services is less long, as well as the lack of skilled personnel in the use and mastery of drive thru technology.


The City Competitiveness refers to a city in the process of competition and developing which compares with other cities has attraction of, competes for, own, control and the transformed resources, seizes, occupies and controls the market, in the creation value, the ability to provide welfare for its resident. The theoretical foundation of City Competitiveness is a quite wide range, which includes: The local marketing, Sustainable development, the urban government; further extends, the national competitiveness, the global competitiveness, which most concerned to all countries around the world. The impact of globalization produces an effect on the cities under a state, and market competition between countries or economies. "Global city" is beyond the country, as the world's important economic, political and cultural strongholds, and leads the direction of globalization. In recent years, scholars of the world committed to research the rankings of the National Competitiveness and the Global Competitiveness. Local Economic Development has become the central issue of Taiwan Government economic policy in recent ten years. However, three is no suitable model for measuring urban competitiveness. The study on related indicators of urban competitiveness include both fields of construction and application; references both of the national Competitiveness and City Competitiveness, exposition multiple value of City Competitiveness, an empirical case study of Kaohsiung City's development; With a view constructing a pointer system model of City Competitiveness with local characteristics and practical operation. By means of document database analysis and management science, to construct the key factors of City Competitiveness, a case study of Kaohsiung City, find out the key factors that impact on local economic development strategy. Based above research, it might be a strong reference to policymaker and decision-making mechanism in decision process.


Martin Dahinden's article 'Democracy Promotion at a Local Level' is a welcome and timely contribution to on-going debates about the meaning of democratisation and external support to democracy. Since the end of the Cold War and with the rise of the 'good governance' agenda, the dominant approach to democracy promotion within multinational institutions as well as bilateral donor agencies has been a rather normative and technocratic one. The role of the West in accompanying transition from auto...


The present invention discloses a cylindrical container base structure and siphon intake gallery applications, includes a box-type tubular structure into soil in a base, and integrally connected thereto siphon corridor, cylindrical box structure comprising a plurality of like base diameter, height and the like, bottomless cylindrical body, the cylindrical body is connected by the connection between any two walls together, the top of the cylinder and surrounded by a top cover plate sections provided, the cover plate can switch defines box cylindrical base through hole, the siphon comprises an intermediate corridor wall, the bag wall, vertical wall, cell energy dissipation, energy dissipation wall, rib, and ribs preformed holes siphon corridor through hole. All the concrete structures of the present invention, having the structure is simple, easy to use, anti-ice sand, fast drying up, the advantages of good durability, but also to avoid corrosion caused by the shutter closed tightly and leaks. The water intake structure can be prefabricated on land, water flotation transportation, convenient on-site installation, construction speed, low cost, strong adaptability to soft ground.


For the first time gas phase radicals have been observed, using the matrix isolation method, during methanol oxidation on a Pt/SiO2 catalyst. A method of identifying the radicals generated is suggested, which utilises the differing resistance of MeO· and MeO·2 radicals to photolysis using the full light of a high pressure mercury lamp.


In order to model rock mass fracturing and destabilizing along various structural planes, in this paper, a cellular automata (CA) model is set up, and a CA evolution algorithm mainly considering energy propagation is developed. A computing program is put forward on Matlab, the evolution process of rock structural plane fracturing and destabilizing is studied, which shows the complexity of rock structural plane destabilizing process.


This paper proposes a data-driven aircraft flight performance comparative analysis method based on QAR data. First of all, select the target aircraft types and the competing types, and randomly extract a certain amount of QAR data for each model, extract the key parameters that reflect the flight performance from QAR data. Secondly, based on the combination of single-parameter analysis and multi-parameter analysis methods, analyze and compare the key performance parameters of each aircraft type. At last, discover and analyze the potential differences in data, in order to provide support for aircraft flight performance improvement and flight safety.


To the editor:

Acute chest syndrome (ACS) is a leading cause of hospitalization and death for people with sickle cell disease (SCD).[1][1] Cigarette smoking has been inconsistently related to an increased risk of ACS in prior studies[2][2],[3][3] and may be one of the few potentially modifiable


The results of a numerical and experimental study of an electric machine with cylindrical permanent magnets are presented. It is shown that if a squirrel-cage rotor in a standard induction motor is replaced by a rotor with permanent magnets, then a significant increase in the specific power of the electric machine can be obtained. Numerical studies and analyses of the characteristics of an electric machine with tangentially magnetized neodymium and ferrite magnets in the motor mode have been carried out. It is shown that in order to ensure maximum specific characteristics for use in electric vehicles, it is necessary to take into account the driving cycle and carry out liquid cooling of the electric motor. Also, a comparison of the characteristics obtained during testing of an experimental sample in the generator mode and the characteristics obtained in the calculation models was made. It is shown that the discrepancy between the calculated and experimental dependences for several values of the rotor speed is no more than 4%. The characteristics of the electrical machines under study were calculated using the Simcenter MagNet and Simcenter MotorSolve software packages. References 7, figures 6, tables 2.


Rural youth are faced with many difficult economic social problems and adjustments. Their rapid increase as a proportion of the total population creates problems of economic opportunity in agriculture. Rural youth have poorer and loss education than urban youth. Facilities and leadership have been looking in the recreational program of rural areas. The principal objective of this study was to discover the factors and conditions in the adjustment of the rural youth of Teton County to the situation in which they find themselves during: the youth period. To gain this objective the personal interview wee used and this material was further supplemented by information from secondary sources. The youth population group of Teton County has tended to increase in proportion to the child and adult population of the county. There has been an extensive migration into the south central part of the county of both children and young adults. No immediate decline in youth numbers in the county can be expected and, therefore, the migration of youth out of the county will continue. A large proportion of Teton County youth have migrated from the county. In t is migratIon they left the fame and moved to villages end cities. These youth entered a wide range of occupations, most of then outside of agricultural fields. Unemployment, lack of work opportunities and low incomes are problems of many of these youth. Those youth remaining have had to adjust themselves to the occupational demands of the county. They average below completion of a high school education* Teton County youth have more formal education than theIr fathers; the village youth received more education than the farm youth; the girls received more then the boys; and the youth leaving the county received more than those youth who remained. The married youth, just establishing households, were having difficulties in securing adequate housing. Tetson County youth's recreational activities were of an Individualistic type, supplemented by such leisure time uses as the radio, reading, and comercial recreation. Asy planning to old Teton County youth In solving their problems oust consider the adjustments youth have node in the past, the number of youth and their present situation In the county, end the attitudes and goals of the local people as they apply to youth as future citisens. RURAL TOUTE ADJUSTMENT IE SELECTED AREAS OF TETOE CCRjm, 1926-19«) by GLEE V. VEEGEROKT A TEESIS Subrdttcd to the Graduate Cmrsaittee in partial fu lf illn e n t o f the requirement* for the Degree o f Ineter o f Science in Agricultural Economic* at Lbntima State College


It is a method for producing a cutting or embossing roll surface with a roll from the basic body protruding cutting blade or embossing projection described. This method will be further formed such that an optimal homogeneity of the cutting knife or the embossing projection while minimizing the length and cost of the production process is ensured. To achieve this objective the following steps are suggested: a) Single or multi-layer coating of the cutting knife or the embossing projection on the roll base body by means of laser cladding, wherein the respective layer is produced with the aid of a powdered additive material, which is melted in a produced at the weld site molten, b) detecting the light emitted from the molten bath of heat and / or light radiation, at least during the application of each layer, and c) controlling or regulating the power of the laser used for laser cladding in response to the emitted heat and / or light radiation of the molten bath, such that the temperature of the molten bath remains constant during the deposition of the respective layer substantially.


The calculation of kerma factors from known cross sections is not as simple as is often implied. The kerma factors are strongly influenced by the reaction mechanism assumed. An important example of this dependence on the reaction mechanism is the contribution of the /sup 12/C(n,n')3..cap alpha.. reaction to the total kerma in carbon. First, a short review will be given of the ENDF/B-V carbon cross sections which were used in the calculation of carbon kerma factors. Using the reaction channels implied in the ENDF/B-V evaluation, the contribution of various reactions to the total kerma factors in carbon will be given. A detailed analysis of the reaction mechanisms which could contribute to the (n,n')3..cap alpha.. reaction in carbon has been carried out. First their contribution to kerma, independent of cross section, will be calculated and then the initial spectra of alpha particles produced by the various reaction mechanisms will be given. A discussion of possible ways of experimentally distinguishing the reaction mechanisms will be made by comparing their different initial spectra and their variation in kerma with neutron energy. Finally, the event-size spectra for tissue-equivalent proportional counters will be presented, giving only the contributions from the (n,n')3..cap alpha.. reaction and itsmore » various possible reaction channels. 3 refs., 11 figs., 4 tabs.« less


Education has an important role in influencing one's attitudes, including attitudes towards the environment. The purpose of writing is to explain how learning through a combination of Problem Based Learning and Group Investigation models in improving attitudes towards the environment. Investigative activities to find out the surrounding environmental problems followed by the process of solving problems encountered during the investigation are a series of learning processes that will foster concern for environmental problems. Knowledge gained from direct experience of real problems found will affect a person's behavior or attitude.


The Vicarious Learner project is investigating the role of dialogue in learning and, more specifically, how learners benefit from opportunities to 'overhear' other learners. We describe evidence of such learning by students using "vicarious learning resources" in a computer-supported learning environment. We argue that education dialogue has properties that are different from "everyday" dialogue. We see educational dialogues in particular as being about the complex alignment of concepts where the participants know that an initial misalignment is fairly certain. We focus on the distinction between exposition and derivation in discourse and discuss how this might describe what happens in learning dialogues.


Mild Cognitive Impairment (MCI) refers to a transitional stage between normal aging and dementia. The purpose of this study was to predict the development of MCI patients based on cognitive functio ...


The advantages and disadvantages of wireless communication systems are the key factors that determine victory or defeat in the war. The construction of military informatization has accelerated in various countries, and the struggle for electromagnetic space has become more intense. Therefore, the communication anti-jamming techniques received extensive concern. It is of great significance to explore a waveform that can communicate effectively under interference. In this paper, the complex electromagnetic environment, typical means of military communication jamming and anti-jamming are analyzed thoroughly. A double-sequence frequency hopping waveform design method based on pseudo-random chirp is proposed, which has some practical value in engineering.


Comorbid anxiety in bipolar disorder (BD) and unipolar major depressive disorder (MDD) is associated with worse symptoms, poorer response to treatment, and higher rates of suicidality. These investigators examined whether comorbid anxiety disorders or symptoms increase impulsivity in 205 patients with BD (mean age, 37 years; 29% male) and …


Humans, other animals and geological processes leave their imprint on the seafloor. The interpretation of such features may be challenging. Very-high-resolution synthetic aperture sonar (SAS) data and seabed photographs (TFish) have recently been acquired from the Barents Sea using the HiSAS 1030 and TFish systems on the autonomous underwater vehicle (AUV) HUGIN HUS. These data demonstrate the clear morphological distinction between iceberg ploughmarks and trawl marks produced during fishing, and also enable the interpretation of small, irregular depressions as whale-feeding marks.

A 13 km2 area was imaged with a very-high-resolution SAS deployed from an AUV (Fig. 1a–c), nested within 175 km2 of conventional hull-mounted multibeam data (Fig. 1d) on the Loppa High, SW Barents Sea (Fig. 1h). Water depths here range from 420 to 440 m. SAS data were processed to give imagery with a resolution of 7×7 cm and bathymetric grids at 20×20 cm. TFish photographs (resolution 5×5 mm/pixel) were also acquired from the AUV from selected sites.

 Fig. 1.
Multibeam bathymetry, SAS imagery and micro-bathymetry, and seafloor photographs of trawl marks, possible whale-feeding marks and iceberg ploughmarks. ( a ) SAS imagery of trawl marks and whale marks. Acquisition system Kongsberg HiSAS 1030 (wideband SAS sonar, frequency 70–100 kHz). ( b ) SAS micro-bathymetry …


During the practices of correspondence teaching,it's easy for teachers to identify key points,however to help students understand difficult questions is not that easy.According to this essay,trying out some unconventional methods targeted at certain difficulties such as presenting in images,breaking down into easy parts,boiling down to the core and relating to reality,etc would be an effective and creative way of cracking teaching obstacles while improving the efficiency of correspondence teaching.


The globalization process in culture, economics, politics, and constant development of information technology, destruction of binary, hierarchical view of the world require reconsideration of the classical humanistic paradigm. The concept of New Humanism may be considered as one of the possible variants of answer to these contemporary challenges. The article deals with the new understandingof humanism, its potential is analyzed as worldview basis of UNESCO scientific, educational and cultural programs. The author underlines that global changes in all aspects of human make new challenges to education and require a new vision of the educational process basing on the humanistic principles. It is pointed out that transculturality, dialogueness, inclusivity, cosmopolitanism, tolerance to Other, assertion of gender equality, priority of education are the main characteristics of the New Humanism. It is concluded that the primary educational task from the position of a New Humanism is formation of humanistic values such as respect of human life and dignity, equal rights and social justice, recognition of cultural and social diversity, a sense of human solidarity and collective responsibility for our common future. This is that great potential of worldview basis of UNESCO educational strategy.


This article analyzes the effect of remittances on aggregate demand and equilibrium income within a Keynesian model. Our analysis demonstrates that the composition of aggregate demand varies because remittances produce an increase in consumption and a contraction in the external sector. The total value of aggregate demand is then reduced by the value of remittances in national currency. Consequently, we confirm that the remittance multiplier is (-1).


This Special Section presents the latest developments on intelligent modeling, neural networks, deep learning, and adaptive estimation, and their applications in industrial applications. Through a rigorous peer-review process, eleven articles have been accepted, which are summarized below.


A highly polished planar Pt electrode was used in an in situ reflection−absorption infrared cell to examine the chemical products of electrochemical reactions of NaNO2 in a methanolic solution in the 2500−1100 cm−1 range. Analysis of the resulting infrared bands showed that methanol reacts directly with the electro-oxidation products of nitrite. The predominant oxidation product was methyl nitrite, with apparent smaller quantities of NO2, NO3−, and NO. The reduction product of in situ-generated methyl nitrite was N2O, presumed to occur via adsorbed N- and O-type species. No other species arising from NxOyHz were observed; however, bands associated with the stretching modes of O−H and N−H that would clearly identify any such products were outside the accessible spectral range examined here due to interfering absorptions from methanol.


ok Re vi ew s 5 0 7 how each through writing took up the question of the Congolese nation, and in sometimes unexpected ways. What is interesting in these chapters is that the author provides an in-depth analysis of individual texts and places them within a broader, Pan-African context. He reads works of Congolese fiction with an eye toward what he calls "polyvocality," or the existence of several voices within one text (93). Thomas argues that the polyvocality within these texts may explain how official and nonofficial prose does not always support or criticize the state as one might expect. An introduction, a chapter on official writers, and a concluding investigation of the media in the nation-making and -breaking process round out the analysis. The last chapter sits slightly askew from the others; it is the only one to depart from the study of literature. Thomas brings his astuteness to the reading of political cartoons of the recent past, in which artists poke fun at Congelese leadership. His examination of the newspaper La Rue Meurt is quite illuminating (180). As this is the acme of the analysis, one wonders, why stop there? Why not examine film or music in order to interrogate other media and the alternative Congolese voices that Thomas searches? But this would have been a different project. The book title is somewhat deceptive in its broad, overarching scope. The investigation consists primarily of literary analysis, and Dominic Thomas is quite skilled at it. He asks good, incisive questions, such as what to do when the good guys (the colonized) become the bad (dictators) (158). He judiciously turns to Congolese authors for a response. To his credit, Thomas seeks to avoid facile binary relationships (colonized versus colonizers). A map of Francophone Africa and the Congo would have been very useful for readers (at least this one). One false note is struck when, at the conclusion of his study, Thomas offers suggestions for all of Africa (190–91). I find it difficult, personally, to make the leaps from Congolese fiction to a brief media study to prognoses on Africa's future. Nonetheless, it is a provocative end to an engaging study.


Abstract The thermodynamic parameters of La(NO3)3 and La(OH)3 are evaluated and the thermodynamics of nano-La2O3 synthetic process is analyzed. On the base of thermodynamic analysis, La2O3 nano-powders are prepared by the sol-gel method and experiment scheme is designed by an orthogonal method. The dry-gelatin is analyzed with different thermal analysis/thermo-gravimetric analysis (THA-DTA) and X-ray diffraction method. The microstructure of nano-La2O3 particles are experimentally examined and analyzed. All the results indicate that nano-La2O3 particles well-dispersed are obtained and the average grain size is in the range of 20–50 nm. *Supported by National Natural Science Foundation of China (Grant Nos. 50402022, 50425415 and 50672006)


Many of us deal with the capital markets on the daily basis-as an investor, broker, dealers or financial analysts. To gauge the performance of the market, every one seeks information on the behavior of the market. The present study is an extensive study that estimates crude oil future series with twenty various GARCH specifications of models. This overall exercise executes an idea on the suitability of a specific specification for estimating volatility among the estimated specifications. The results reveal that among the twenty GARCH specifications of models, GJR specifications are found to be better than GARCH and EGARCH specifications.


Three aspects of Chinese economic familism are distinguished: nepotism, paternalism, and family ownership. This essay is mainly concerned with the last aspect and the resultant phenomenon of the prevalence of family firms among privately owned Chinese commercial and industrial enterprises. It is argued that such firms are not necessarily small, impermanent, and conservative, because they tend to behave differently at various stages of their developmental cycle. Four phases of development—emergent, centralized, segmented, and disintegrative—are identified and discussed. This Chinese pattern is then compared with its Filipino and Japanese counterparts.


This experiment was conducted to study the effects of different relative humidity(RH) and ammonia(NH3) stress in poultry house on plasma ammonia level and cytokine contents of broilers.A total of 288 21-day-old broilers with an average bodyweight were divided into 6 treatments with 6 replicates per treatment and 8 broilers per replicate.The 6 treatments were as follows: Treatment 1,30 mg/kg NH3+ 35% RH;treatment 2,30 mg/kg NH3+ 60% RH,treatment 3,30 mg/kg NH3+ 85% RH;treatment 4,70 mg/kg NH3+ 35% RH;treatment 5,70 mg/kg NH3+ 60% RH;treatment 6,70 mg/kg NH3+ 85% RH.The experiment was conducted in climate chambers,and the experiment lasted for 3 weeks.The results showed as follows: 1) NH3 concentration had a significant influence on plasma ammonia level(P 0.05),the plasma ammonia level was increased with the increase of time in climate chambers.2) RH had a significant influence on serum interleukin 1β(IL-1β) content at 3 weeks in climate chambers(P 0.05),the contents of IL-1β and interleukin 6(IL-6) in serum were increased with the increase of time in climate chambers.3) NH3 concentration had a significant influence on serum interleukin 4(IL-4) content at 1 and 2 weeks in climate chambers(P 0.05),also had a significant influence on serum interleukin 10(IL-10) content at 1 and 3 weeks in climate chambers(P 0.05).RH had a significant influence on serum IL-10 content at 1 week in climate chambers(P 0.05).It is concluded that RH and NH3 stress impair the immune function of broilers.With the increase of time in climate chambers,the body obtains certain ability to adapt to the environment,the immunosuppressive effects has a reduced tendency.Moreover,the immune suppression of broilers caused by 70 mg/kg NH3+ 85% RH cannot be alleviated.


This study summarizes econometric findings from time-series research on the relationships between cigarette consumption and advertising, price, and income using a meta-analysis methodology. The study also investigates the trends in these relationships over time, controlling for possible confounding effects of design variables in the studies analyzed. The results show that the advertising and income elasticities are positive and significant on average across studies, and the average price elasticity is significantly negative. The elasticities vary across countries and design factors and have become smaller over time. Implications for public policy and future research are discussed.


Abstract Disinformation represents a pressing issue in the context of security and politics in the region (not only) of Central and Eastern Europe. With the conflict in Ukraine, European virtual space was flooded with online media offering alternative explanations concerning the situation in that country. So-called alternative media developed into trusted sources of information for part of society. Therefore, this paper analyzes in-depth the techniques of manipulation they use; in other words, the aim of the paper is to deconstruct their power over peoples' hearts and minds. Through the case of the Czech Republic, we demonstrate modernized manipulation of public opinion based on a selective choice of topics and stories combined with properly chosen manipulative techniques controlling emotions and relativity.


AYI DIANITASARI. The Implementation of Audio Watermarking Technique using Phase Coding Method. Supervised by SHELVIE NIDYA NEYMAN. Today, digital data has substituted analog data in various applications. The digital data is easier to make, manipulate and distribute, these are the advantages of the digital data. Otherwise, copyright protection is one of the problems using the digital data. The wider of the use of computer network and technology make digital data easier to distribute illegally at the lower cost and qualified content. This problem could be handled by the digital watermarking, a technology which allows a secret message to be hidden in digital data, without the detection of a user. The watermark is not apparent to the user, and does not affect in any way, the use of the original data. Audio watermarking is the part of digital watermarking. Audio watermarking is the information insertion process to the audio and the extraction process to retrieve the information without influence the audio quality. In this research, implemented audio watermarking to the wav audio data using Phase Coding method that works in the frequency domain. The phase coding method works by substituting the phase of an initial audio segment with a reference phase that represents the watermark data. Phase coding method resulted the PSNR (Peak Signal to Noise Ratio) value as the quality measurement. Based on the analysis result, the watermarked audio quality using this method is above 30 db and the watermark file can be extracted in the value of BER (Bit Error Rate) = 0%. Phase coding method has passed 5 (five) attacks as an analysis benchmarking, the attacks are resampling, cropping, noise addition, time stretching, and multiple watermark with the same information and also different information. Based on the analysis benchmarking result, phase coding method only robust to the resampling and noise addition attacks. This audio watermarking technique using phase coding method implemented using Matlab 7.0.1


Traditional cognitive testing for older adults can be inaccessible, expensive, and time consuming. The development of computerized cognitive tests (CCTs) has made strides to alleviate such issues with traditional cognitive testing. Self-administered CCTs allow for individuals to test rapidly and conveniently on various devices. However, such tests may not factor in relevant contextual information pertinent to the testing situation (e.g., is the user in a proper environment or context to test?). This dissertation aims to develop a mobile, context-aware cognitive testing system (CACTS) capable of tracking and analyzing contextual information during CCTs. By utilizing mobile device sensors and user input, the proposed context-aware system will capture ambient and behavioral data during testing to compliment user performance results. This research will help provide insight into the contextual factors that are relevant to the user's testing efficacy and performance in CCTs.


Waste telecommunication equipment generated by the domestic mobile telecommunication industry is classified and distributed, not as waste electrical and electronic equipment, but as scrap iron, which can cause international problems such as violations of the agreements of the Basel Convention on the control of transboundary movement of hazardous waste and its disposal. The purpose of the study is to establish the infrastructure for the correct implementation of an export-and-import declaration by determining both the identification of hazardous materials and the composition ratio for recycling waste mobile communication equipment. In total, 16 pieces of waste equipment from three companies was collected for leaching and contest analysis: repeaters, base stations, antennae, cables, batteries, and wires. In the resultant composition ratio, 99% of a coupler and more than 80% of a repeater sample were composed of scrap metal, whereas 30 ~ 50% of a base station sample was made of printed circuit board (PCB). The lead leaching concentrations in two PCBs exceeded the standard value (13.9 mg/L and 5.5 mg/L), which means that it is necessary to control them in the transboundary movement of waste. The type and concentration of hazardous chemicals are different for each component and product, suggesting that waste mobile communication equipment has to be separated and sent out in parts.


Suaeda heteroptera (S. heteroptera) is the most common indicator plant of solonchak in coastal wetlands of the Liao River Estuary, the influence of meteorology, hydrology environment on vegetation distribution is of growing interest. With the help of satellite remote sensing (RS) technology and geographic information system (GIS), we investigated the spatial-temporal distribution and area change of S. heteroptera in the wetlands of the Liao River Estuary from 1997 to 2016, and the identification of the main driving mechanisms in the S. heteroptera evolution was analyzed in this coastal wetland. The SPSS Statistics 22 software was used to calculate the correlation coefficients between total area of S. heteroptera and each driving factor based on available long-term (1997-2016) and medium-term (2007-2016) data. Correlation analysis results indicated that the change in S. heteroptera coverage had insignificant correlations (correlation coefficients r=−0.241, r=−0.188 and r=−0.269) with annual mean temperature, precipitation, and sunshine duration, respectively. The results also showed that the growth of S. heteroptera was extremely relevant to runoff from the Liao River from April to June (r=0.889) over the last 10 years. This study revealed that some potential factors, such as river discharge may be related to the large-scale degeneration of S. heteroptera in Liao River Estuary wetlands.


The translucence and color change in wood methods, which are commonly used to differentiate sapwood from heartwood in tree cores, are compared against the microscopic analysis of wood anatomy method for determining sapwood depth. The translucence method was tested on collected wood cores of White Spruce (Picea glauca (Moench) Voss) and Jack Pine (Pinus banksiana Lamb.). The color change in wood method was tested on Trembling Aspen (Populus tremuloides Michx.). For every statistical comparison, sapwood depth values obtained with the translucence or color-change methods were significantly different from those obtained using the microscopic analysis. Using the sapwood depth values obtained with microscopy as a reference, the bias associated with the translucence or color-change methods used on Picea glauca, Pinus banksiana and Populus tremuloides constantly under- or overestimated sapwood depths within −0.3 cm to 1.6 cm; −4.9 cm to 0.5 cm; and 0 to 1.8 cm, respectively. The different ranges of over- and underestimation arise from species-specific anatomical characteristics. Estimates for the errors in sapwood depth, when the depth is measured using either the translucence or color-change methods, are presented. These relationships and research outcomes will lead to more efficient forest monitoring and improved estimates of forest water balance, which in turn will lead to improved forest management in the face of climate change.


The types of bacteria and their extracellular catabolic enzyme activity in a mixed bacterial culture, developed to bring about appreciable softening of hard root-cuttings of jute, were characterized. The bacterial population showed a typical diauxic growth and started secreting enzymes after 48 h of growth, which coincided with the beginning of softening process. D-glucose, a catabolite repressor, inhibited softening as well as the synthesis of bacterial extracellular proteins by 97% when added within two and a half days of incubation, later addition being ineffective. Bacterial cell-free culture supernatant, having catabolic enzyme activities, such as those of pectin transeliminase, polygalacturonase, pectin methylesterase, (jute) hemicellulase and CMCase, liberated sugars from sterile root-cuttings but was unable to bring about softening to the extent comparable to in-situ bacterial growth. However, when the supernatant was added along with the ruptured bacterial cell solids, the degree of softening was increased by 17%. A similar observation of partial softening was observed when the sterile cuttings were treated with a combination of proprietary fungal enzymes.


Collaborative systems Quality management discipline requires a set of assessment mechanisms to evaluate external quality characteristics influenced by environmental parameters and impacted by ecosystem factors. The present paper suggests a new assessment oriented model to assess and monitor quality performance. The proposed model, named RatQual, gives a hierarchical categorization for collaborative systems quality factors. RatQual is designed to quantify dependent-environment qualities by considering internal, external and in use aspects. This model is supported by a tool that automates the assessment process. This tool gives assistance in quality evolution planning and serves for periodical monitoring operations used to enhance and improve information system quality.


This paper argues that the components of globalization (economic integration, democratization, and global governance networks) are changing the nature of corporate governance and the prospects for peace. Multinational enterprises are the instruments of economic integration. As such, multinationals as a group deserve credit for the positive productivity-related wealth effects of the process. As the implementing institution, these enterprises are also inextricably related to the inequality--the social void--resulting from globalization that threatens peace. Hyper competition in the global product markets and the demands of the financial markets determine, to a large extent, the activities of the multinational. Alternatively, there is an evolving opportunity for management to participate in a socially positive way with global governance networks that are gradually assuming the regulatory role from national governments. Within these market and governance constraints, individual firms have an opportunity to mitigate the negative pressures on their various constituencies thus contributing to development and the


We use elementary arguments to prove results on the order of magnitude of certain sums concerning the gcd's and lcm's of [Formula: see text] positive integers, where [Formula: see text] is fixed. We refine and generalize an asymptotic formula of Bordellès [Mean values of generalized gcd-sum and lcm-sum functions, J. Integer Seq. 10 (2007) Article ID:07.9.2, 13[Formula: see text]pp], and extend certain related results of Hilberdink and Tóth [On the average value of the least common multiple of [Formula: see text] positive integers, J. Number Theory 169 (2016) 327–341]. We also formulate some conjectures and open problems.


In this paper, the subgrade subsidence causes of Huannan line in k194+480~k196+960 are analyzed,and the material properties,design and construction of geoweb are also discussed. Through analyzing the in situ measurements of dynamic stress in subgrade soil and strain of geoweb under railway load,the treatment mechanism of subgrade subsidence is studied.The results show that the geoweb can increase the bearing capacity of sand cusion and improve subgrade dynamic stress under sand cusion.


The electro-optic Pockels effect may be generated in silicon photonics structures by breaking the crystal symmetry by means of a highly stressing cladding layer (typically silicon nitride, SiN) deposited on top of the silicon waveguide. In this work, the influence of the waveguide parameters on the strain distribution and its overlap with the optical mode to enhance the Pockels effect has been analyzed. The optimum waveguide structure have been designed based on the definition and quantification of a figure of merit. The fabrication of highly stressing SiN layers by PECVD has also been optimized to characterize the designed structures. The residual stress has been controlled during the growth process by analyzing the influence of the main deposition parameters. Therefore, two identical samples with low and high stress conditions were fabricated and electro-optically characterized to test the induced Pockels effect and the influence of carrier effects. Electro-optical modulation was only measured in the sample with the high stressing SiN layer that could be attributed to the Pockels effect. Nevertheless, the influence of carriers were also observed thus making necessary additional experiments to decouple both effects.


LOVERS of Virgil will welcome gladly a volume to follow The Gathering of the Clans, and in Aeneas at the Site of Rome they will find no disappointment. Dr. Warde Fowler has made it clear here to any who still needed such teaching what prompted him once to confess: 'The study of Virgil is for me one of the things that make life worth living.' His clearness of vision seizes and interprets the elements in Virgil's work that are of permanent value to humanity, the catholicity of appeal which entitles Virgil to be ranked with Homer, with Shakespeare, and with the great religious teachers of mankind.


441 Background: Gemcitabine and nab-paclitaxel has been reported to prolong survival in patients with metastatic pancreatic cancer. This drug combination was studied in such patients in the MPACT trial with an average age of enrolled patients being 63. Pancreatic cancer, however, is a disease of the aging with a median age at diagnosis of 70. Reductions in dosing by 20% or more in one or both components and has been shown to improve the tolerability of this regimen, thereby increasing treatment exposure. Our study aims to examine the efficacy and tolerability of this drug combination in an elderly population and how this is affected by schedule and dosing modifications. Methods: A retrospective chart review was performed of 83 patients over the age of 70 with a median age of 79 who received this drug combination as first-line treatment for pancreatic adenocarcinoma at a single institution. Overall survival and progression-free survival were assessed as well as schedule modification, dose reduction, and rates of adverse events. Results: For patients with metastatic or non-metastatic disease, the mean overall survival and progression-free survival were found to be 10.57 months and 6.63 months, respectively. When only patients with metastatic disease are analyzed, these values were found to be 9.26 months and 6.05 months, respectively, which are similar to those observed in the MPACT trial. The most common adverse events of grade 3 or greater were fatigue in 34.9% of patients and hematologic adverse events including neutropenia in 27.7% and leukopenia in 25.3% of patients. Dose reductions were commonly used to mitigate adverse events. Reductions in either one or both drugs by at least 20% occurred in 84.3% of patients. Conclusions: Gemcitabine and nab-paclitaxel in treatment of pancreatic cancer is well tolerated in an elderly population with similar rates of adverse effects when compared with previous studies, though this population experienced a significantly higher rate of fatigue. Dose reductions were used frequently in this population to improve tolerability, which may have contributed to the observed increase in overall survival in this population.


In recent years, the application of high resolution remote sensing images has become more and more widely with the development of Remote Sensing technology. QuickBird satellite image is the more commercial used high resolution remote sensing image, but due to its technical confidentiality, high-resolution satellite generally does not provide rigorous sensor model. This paper uses ERDAS10.0 to orthographic check the QuickBird image by the method of orthorectification, introduces the method and procedure of the orthogonal projection like drawing, analysis the positioning accuracy.


A common problem in forestry is plant death caused by frost. The risk of frost is highest on wind protected, flat or low-lying areas in the terrain. Here you often have regeneration problems with Norwegian spruce which is especially sensitive to spring frost. Swedish tree experiments have shown that the black spruce can be a suitable alternative on these areas, for example on moisture frost prone areas. The species originates from North America and its pioneer tree characteristics make it more frost hardy than Norwegian spruce. It is also relatively free from damages and in Canada the light wood makes it sought after as pulpwood.
In this study areas suitable for culturing black spruce in northern Sweden were identified, where it can compete with Norwegian spruce.
By the creation of a map model based on different map material, the suitable areas could be selected. First, a slope model including low-lying and flat areas of a certain size was created. Thereafter a selection of the different land covers was made in a map layer. The land covers that were selected were forested mires, peatery and swamp forests. When the slope model and the selected land covers were run together it resulted in a polygon map with areas that met the requirements of land cover as well as slope and surface area. To be able to present the result in a suitable way, the area within Asele municipality was chosen as delimitation. The total area of suitable black spruce areas within Asele municipality was calculated to 7118 ha. That corresponded to about 1,6 % of the total land area, when water surfaces was excluded.


We present a rigorous method giving the field scattered by a dielectric plane surface with a local cylindrical perturbation illuminated by a plane wave. The theory is based on Maxwell's equations written in a nonorthogonal coordinate system. A Method of Moments (PPMoM) with Pulses for basis and weighting functions is applied for solving in the spectral domain. For several deterministic profiles, we study the influence of polarization, incidence angle and perturbation depth and show that the distance defining the far-field approximation depends on the observation angle.


Christine Lindstrøm works as an Associate Professor of Science in the Faculty of Teacher Education at Oslo and Akershus University College in Oslo, Norway, where she teaches physics and science education to pre-service science teachers. She undertook her tertiary studies at the University of Sydney, Australia, from which she has a Bachelor of Science (Honours), Master of Education and PhD in Physics. Christine's PhD project was in Physics Education Research, where she focused on improving the first year physics course by developing and implementing 'Link Maps', as well as synthesising an understanding of physics student learning by integrating a variety of theoretical backgrounds, from neuroscience via cognitive psychology to educational theories. Christine's current research focuses on improving the science teacher education program at Oslo and Akershus University College, and she has a keen interest in how the brain learns physics. Christine also holds a position as Adjunct Associate Professor of University Pedagogy at the Norwegian University of Science and Technology, where she teaches short courses on university teaching to PhD students and researchers.


Opinion Dynamics models can be, for most of them, divided between discrete and continuous. They are used in different circumstances and the relationship between them is not clear. Here we will explore the relationship between a model where choices are discrete but opinions are a continuous function (the Continuous Opinions and Discrete Actions, CODA, model) and traditional discrete models. I will show that, when CODA is altered to include reasoning about the influence one agent can have on its own neighbors, agreement and disagreement no longer have the same importance. The limit when an agent considers itself to be more and more influent will be studied and we will see that one recovers discrete dynamics, like those of the voter model in that limit.


Once considered the domain of higher education, the flipped classroom is increasingly being implemented in secondary school settings. Although enactments of the approach vary, it typically involves the use of digital technologies to shift direct instruction to the home environment, providing for more targeted in-class teaching. This paper describes how a flipped classroom approach was enacted in a senior secondary mathematics classroom and reports on the students' and teacher's perceptions of the impact of the approach in terms of students' engagement with mathematics. It adds to the limited research in this area through providing an account of how flipping the classroom works in practice and its potential for engaging students in mathematics.


Abstract Preparative scale polyacrylamide gel electrophoresis has been employed for isolating milligram quantities of globin messenger RNA from total RNA of rabbit reticulocyte ribosomes. Adherence to defined conditions for gel formulation, polymerization and electrophoresis have allowed recovery of globin messenger RNA within 24 hours electrophoresis time. The biologic activity of mRNA so isolated has been determined by assay in mRNA-dependent protein synthesis systems, and the products identified by standard procedures as rabbit globin. Application of preparative scale polyacrylamide gel electrophoresis for isolating other mRNAs as well as for resolving various similar molecular weight messenger RNAs (i. e., alpha-and beta-globin messages) is concluded to be feasible and is being investigated.


The AnyCasting Casting Simulation Software was used to simulate the castings process of a nodular iron exhaust manifold cast with sand mold,to analyze its flow field and temperature field,and to forecast the defects that may occur in the casting,locations and sizes of defects.It was found that the results of simulation and analysis were basically in agreement with the experimental results.Hereby,the measures to improve the pouring rate and gate section area were proposed.Satisfactory casting was obtained after conducting test again with the improved casting method.


An exercise for teaching transient stability In this paper, the transient stability limits of a synchronous machine for various initial loadings have been determined in terms of its steady-state stability limit.


Viewing a G-graded k-coalgebra over the field $k$ as a right $k$ G-comodule coalgebra it is possible to use a Hopf algebraic approach to the study of coalgebras graded by an arbitrary group that was started in [NT]. Let $C=\oplus_{g\in G}C_{g}$ be a G-graded coalgebra. The graded C-comodules may be viewed as comodules over the smash product $C\rangle\triangleleft kG$ , the general definition of which was given in [M]. Coalgebras graded by an arbitrary group have been considered in [FM] in order to lntroduce the notion of G-graded Hopf algebras. On the other hand, M. Takeuchi introduced in [T] the sets of preequivalence data connecting categories of comodules over two coalgebras (we call such a set a Morita-Takeuchi context). The main result of this note is a coalgebra version of a result established by M. Cohen, S. Montgomery in [CM] for group-graded rings: for a graded coalgebra $C$ the coalgebras $C_{1}$ and $C\rangle\not\in kG$ are connected by a Morita-Takeuchi context in which one of the structure maps is injective. Most of the results in this note are consequences of the foregoing. As a first application we find that a coalgebra $C$ is strongly graded if and only if the other structure map of the context is also injective. The final section provides analogues of the Cohen-Montgomery duality theorems: if $C$ is a coalgebra graded by the flnite group $G$ of order $n$ , then $G$ acts on the smash coproduct as a group of automorphisms of coalgebras and $(C\rangle\triangleleft kG)*kG^{*}$ is coalgebra isomorphic to the comatrix coalgebra $M^{c}(n, C)$ . If $G$ is a finite group of order $n$ , acting on the coalgebra $D$ as a group of coalgebra automorphisms, then the smash coproduct $D\rangle\triangleleft kG^{*}$ is strongly graded by $G$ and moreover:


This paper is centered on a new form of adaptive material which functions much in the same way as skeletal muscle tissue, is structurally modeled on plant actuator cells and capable of rapidly expanding or shrinking by as much as an order of magnitude in prescribed directions. Rapid changes of plant cell shape and sizes are often initiated via ion-transport driven fluid migration and resulting turgor pressure variation. Certain plant cellular structures like those in Mimosa pudica (sensitive plant), Albizia julibrissin (Mimosa tree), or Dionaea muscipula (Venus Flytrap) all exhibit actuation physiology which employs such turgor pressure manipulation. The paper begins with dynamic micrographs of a sectioned basal articulation joint from A. julibrissin. These figures show large cellular dimensional changes as the structure undergoes foliage articulation. By mimicking such structures in aircraft flight control mechanisms, extremely lightweight pneumatic control surface actuators can be designed. This paper shows several fundamental layouts of such surfaces with actuator elements made exclusively from FAA-certifiable materials, summarizes their structural mechanics and shows actuator power and energy densities that are higher than nearly all classes of conventional adaptive materials available today. A sample flap structure is shown to possess the ability to change its shape and structural stiffness as its cell pressures are manipulated, which in turn changes the surface lift-curve slope when exposed to airflows. Because the structural stiffness can be altered, it is also shown that the commanded section lift-curve slope can be similarly controlled between 1.2 and 6.2 rad−1. Several aircraft weight reduction principles are also shown to come into play as the need to concentrate loads to pass through point actuators is eliminated. The paper concludes with a summary of interrelated performance and airframe-level improvements including enhanced gust rejection, load alleviation, ride quality, fatigue life and flight safety.


The only change in the constituents of the cerebra-spinal fluid recorded after 10 punctures of the cisterna magna, with replacement of the fluid by physiological saline, was a slight decrease in the glucose values.


ABSTRACT Sun, B.; Yang, X., and Cui, Y., 2019. Quality and safety factors in aquatic products circulation: a case study of Dalian city. In: Gong, D.; Zhu, H., and Liu, R. (eds.), Selected Topics in Coastal Research: Engineering, Industry, Economy, and Sustainable Development. Journal of Coastal Research, Special Issue No. 94, pp. 950–954. Coconut Creek (Florida), ISSN 0749-0208. Aquatic products objectively have higher requirements on circulation for its fresh characteristics and the quality and safety problems are complex. Affected by food quality and safety incidents in recent years, residents have a skeptical attitude towards the quality and safety of aquatic products. Therefore, the study on the aquatic product quality and safety is becoming more and more important. Dalian is a coastal city, and the quatic products are the main foods. Based on the five aspects of the circulation of aquatic products in Dalian, such as the source of circulation, processing, transportation, wholesale and retail, this paper analyzes the causes of the problems and analyzes the factors affecting the quality and safety of aquatic products in Dalian city by analytic hierarchy process (AHP). The weight of each influencing factor is determined, and the main factors in each criterion layer are analyzed. These factors include water environment pollution, cold chain logistics technology factors, government supervision strength factors and circulation subject quality and safety awareness factors.


This article describes research related to sampling techniques for establishing linear relations between land surface parameters and remotely-sensed data. Predictive relations are estimated between percentage tree cover in a savanna environment and a normalized difference vegetation index (NDVI) derived from the Thematic Mapper sensor. Spatial autocorrelation in original measurements and regression residuals is examined using semi-variogram analysis at several spatial resolutions. Sampling schemes are then tested to examine the effects of autocorrelation on predictive linear models in cases of small sample sizes. Regression models between image and ground data are affected by the spatial resolution of analysis. Reducing the influence of spatial autocorrelation by enforcing minimum distances between samples may also improve empirical models which relate ground parameters to satellite data.


Chinese female middle-distance race athletes have made many splendid achievements before, but when some elite athletes are retired, it makes Chinese female middle-distance race get into a valley again. We try to find out the differences between Chinese female middle-distance race athletes and foreign female elite middle-distance race athletes, and provide some references for the training of Chinese female middle-distance race athletes by comparing and analyzing the subsection-achievement in the long distance race.


Abstract Allozyme electrophoresis was used to investigate genetic population structure among 245 individuals of the silverside Odontesthes argentinensis sampled from localities in southern Brazil and Uruguay. Striking differences in allozyme frequencies and genetic variability were detected among localities. Analysis of these differences indicated two distinct populations: one distributed in a wide marine coastal zone; and one in the peripheral environment of the Patos Lagoon estuary in southern Brazil. The population in Patos Lagoon appears to have originated from an ancestral marine population and been established in the estuary by a founder effect. The extent and pattern of genetic divergence found in our study, the existence of diverse reproductive strategies in the estuarine silversides, and differences in morphology of eggs and larvae, indicate that speciation is taking place in Patos Lagoon. It is suggested that the two populations should be considered separately when formulating management and conservation strategies.


This paper analyzes why there has been great development of the international sports after World War II and its enlightenment for the Chinese sports.It is held that China should make new sports development strategies and establish good international images in order to serve for constructing China into a sports powerful country and for helping build a harmonious world.


It is our great pleasure to come up with our fourth issues of Mathematics Education Forum Chitwan (MEFC) as a peer-reviewed journal.


Cancer is one of the most common death causes worldwide. Breast and genital cancers in women and prostate cancer in men constitute three of the most common cancers. Detection and prevention of these types of cancers are critical objectives. Recent findings indicate that some patients suffer from cancer comorbidity. The probability of survival among patients with comorbid condition is lower than those with only one type of cancer. The importance of concomitant chronic illnesses during cancer treatment through the SEER data is assessed through many machine‐learning approaches. In order to improve the accuracy of prediction of survival rates in patients with cancer and comorbidity of cancers, the gradient boosting ensemble method is adopted for feature selection and modelling. This proposed method increases the accuracy rate and reduces the error rate, and exhibits a significant predictive improvement of survival rates in comorbid cancer compared with the previous proposed models.


The proposed protocol Secure AODV – ESBF (Adhoc on Demand Distance Vector based on Energy level and Signal Strength Implementing Bayesian Probability and Fuzzy Logic) is a modification of existing dynamic protocol AODV. In AODV protocol Hop count is considered as metric for the process of route selection. Whereas in proposed protocol route is selected based on Energy Level of nodes and Signal strength that exist between them. Since Energy level and signal strength act as two factors that determine effectiveness of the route, Bayesian probability is implemented to select optimized path in a more accurate and efficient manner. In selected optimal paths the RREQ will be forwarded and reach destination. As need for efficiency of the routing, the security of the routing is also of immense importance. The security to protocol is implemented in two phases. In first phase, security is provided by preventing from selecting malicious node as the neighbor node and simultaneously preventing from RREQ forwarded to the malicious node by eliminating it. The insecure nodes are eliminated and efficient neighbors are selected and RREQ is forwarded to limited neighboring nodes based on energy level of nodes and signal strength of links implementing the Bayesian probability. The second phase of security is implied by implementing the Two Fish cryptography algorithm during process of data transmission from source node to the destination. To further improve the efficiency of Bayesian implemented modified secure AODV protocol in this work, the fuzzy logic is implemented. Fuzzy logic is implemented in destination node in process of selecting more stable path from routes forwarded from source node. The simulations are performed in NS2 network simulator and results proves that the proposed protocol is efficient compared to the AODV protocol and other earlier modifications of AODV protocol.


Introduction: According to the National Survey on Drug Use and Health (NSDUH), marijuana is the most commonly used illicit drug worldwide. In the United States and Europe, prevalence of regular marijuana use among adults reaches 4%. Despite the common belief that cannabinoids have an antiemetic effect, chronic use of cannabinoids can result in paradoxical bouts of abdominal pain, nausea and vomiting. Cannabinoid hyperemesis syndrome (CHS) is still an under recognized clinical entity and its diagnosis can be challenging to many clinicians due to the similarity of its clinical presentation to other more common disorders. Case Report: We found that patients who were diagnosed with CHS have usually undergone an extensive clinical evaluation before the diagnosis was made. We are presenting a case of cannabinoid hyperemesis syndrome related to chronic and heavy marijuana use. Conclusion: Compared to the increasing use of marijuana worldwide, cannabinoid hyperemesis syndrome is still an under recognized condition.


This paper describes a scheme for solving a system of simultaneous equations. Under appropriate conditions, we give an algorithm which provides an alternating sequence tending to the solution. The discussion can be considered as an extension of the Intermediate Value Theorem for vector equations. In view of the complexity of the problem, the scheme is surprisingly simple, and understandable to undergraduates. The algorithm can be readily implemented by a computer program, and the initial guess does not have to be close to the solution. The scheme is elsewhere being adapted to study systems of partial differential equations related to ecology and other applications.


Introduction. Two puzzles 1. The president's legislative policy agenda 2. Studying agenda building 3. A theory of presidential legislative policy agenda building 4. The size of the president's agenda 5. The substantive content of presidential agenda 6. Divided government and presidential policy moderation 7. From the White House to Capitol Hill: presidential agenda success in Congress 8. Conclusions.


Abstract This paper reviews the results of a qualitative metasummary exploring parents' experiences of a transgender and gender nonconforming (TGNC) child's initial identity disclosure conversations or the parent's initial awareness of their child's gender identity. We conducted a systematic literature search, resulting in 22 peer-reviewed articles with qualitative data collected from parent participants. Data analysis resulted in two primary themes, five subthemes, and 25 total findings, which we describe in the findings section. The discussion section articulates how these findings may benefit healthcare providers serving parents and their TGNC identified children. This paper concludes with an invitation for healthcare providers to provide services that address the needs of TGNC children, parents, and the relational bond existing between them.


When a right management device (7) receives from an information reproduction device (5) a first request to inquire the right and reproduction conditions of digital contents, a content reproduction system (2) refers to a right management database to acquire the right condition, acquires the reproduction condition from an information reproduction device that owns the right to reproduce the digital contents, and transmits a first response indicative of the right and reproduction conditions of the digital contents to the information reproduction device (5).  When the information reproduction device (5) judges that the digital contents are not reproduced in accordance with the reproduction condition of the received first response, the information reproduction device (5) transfers the right to reproduce the digital contents from the information reproduction device that owns the right to reproduce the digital contents to the information reproduction device (5) in accordance with the right condition of the received first response.


The bachelor thesis is focused on implementation of marketing and marketing management in company JS Communication s.r.o. The goal is based on the analysis to propose new marketing tools that will help the company in further develop. The theoretical part contains the issue of marketing services, marketing management and marketing in an educational institution, because the company is mainly engaged in the provision of educational events. The practical part is devoted to introducing the company and its current application of marketing. Then there are performed some specific analysis describing the situation in the company. These analyses are used as a basis for recommending the introduction of new marketing tools and measures. Subsequently there is done time, cost and risk analysis of the recommended tools.


Asian Paints Umited and International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) collaborated
to improve rural livelihoods through integrated watershed development programme. Six villages in Patancheru
mandal of Medak district, Telangana, India covering an area of 7143 ha were selected in consultation with the
local community for Asian Paints Limited-ICRISAT watershed. The prime mitigation strategy for addressing
water scarcity was initiated in the project by rainwater harvesting, efficient use of available water resources and recycling of grey water...


This paper focused on the promotion of hospitality and tourism activities through the provision of library services. Information is a valuable resource for enterprises and people alike because they rely on correct information to perform daily activities. Libraries act as gateway or access point to information, concepts, and works of creativity. Services in libraries and information centres play an important role in the advancement of hospitality and tourism businesses. The paper focuses on essential library and information services to promote hospitality and tourism businesses. These library and information services include: making available resources such as maps, directories, bibliographies, biographies, referral services to mention but few. The services highlighted are aimed to promote hospitality and tourism activities in the 21st century.


This review covers the recent literature on oxidative generation of N-centered radicals using photoredox catalysis. The concept of proton-coupled electron transfer is briefly discussed. Applications of such reactive N-centered radicals in cascade processes comprising arene amidation, alkene amidation, C—C bond cleavage reactions, and remote C—H functionalization are addressed. In addition, novel reagents allowing for clean oxidative N-radical generation are discussed.


The invention discloses a non-contact power transmission device for an aircraft tire pressure real-time monitoring system, which comprises a primary DC power supply, a primary converter, a rotary transformer, a secondary converter and a secondary DC power supply, and is characterized in that the primary converter comprises a PWM controller and an inverter network, and the secondary converter comprises a rectifier filter circuit and a voltage stabilizing conversion circuit; the primary DC power supply directly inputs into the inverter network in the primary converter, realizes inversion through the inverter network controlled by the PWM controller, inverts the DC power supply into PWM wave, applies the wave to both ends of a primary winding of the rotary transformer, and produces induced voltage in a secondary winding of the rotary transformer; and the induced voltage subsequently passes through the rectifier filter circuit and the voltage stabilizing conversion circuit of the secondary converter, and is output to the secondary DC power supply. The non-contact power transmission device for the aircraft tire pressure real-time monitoring system can be applied on an aircraft in the adverse environment, thereby preventing adding any capacitor with very large size and very large capacity.


Nanotechnology is used to produce the materials in the nano meter size range either by top-down or bottom-up process 1 . Its properties are varied based on their size, shape and surface functional properties with respect to the site of administration 2 . The nanoparticles due to its smaller size and enhanced surface properties possessing high surface area, leads to greater chemical and biological activity. It can also get absorbed onto the surface of the macro molecules 3-5 .


The reasons of tree kinds of leakage (leakage of air, full oil, lubricating oil and water) of diesel locomotive's pipeline connection were analyzed. To resolve the leakage problem, a measure that the traditional pipe connection is replaced by the iron-based shape memory alloy pipe connection was put forward. And feasibility of this measure was demonstrated in detail.


Experiments were conducted to recognize and possibly distinguish oil cracking in conventional reservoir rock versus source rock. Oil and source rock samples were heated in pressure vessels at 380 o C for 72 hours, which resulted in oil cracking to gas and pyrobitumen, with some residual liquid. The oil samples were heated with different minerals (fine-grained quartz, calcium carbonate, montmorillonite, kaolinite and illite) employing different ratios of the oil to the mineral in each case. Heating oil with quartz or calcium carbonate was used as a proxy for reservoir cracking conditions, while heating oil with clay minerals was used as a proxy for cracking within a source rock. Adjustments in the amount of oil mixed with the mineral and differences in the oil types and source rock types were used to investigate those situations. Based on the experiments, oil cracking in source rock versus reservoir rock can be differentiated by relative concentrations of the prominent C 7 hydrocarbons: methylcyclohexane, methylbenzene (toluene) and n-heptane in the liquid products. Ratios of the prominent C 6 hydrocarbons: cyclohexane, n-hexane and methylcyclopentane did not show a systematic or parallel effect and did not appear to depend systematically on the proxies we tested. Diamondoids as thermal robust nanoparticle could be formed at highly mature and over-mature stages with high catalytic effects of clay minerals. Calcium carbonate inhibits the formation of diamondoids at highly mature and over-mature stages.


Experiments have been carried out on the properties of a hollow cathode as an ion-source. The measured electron density, ion and neutral temperatures and drift velocities have been compared with predictions from the conservation laws for matter, momentum and energy. Very large exit drift velocities of ions and neutrals are observed. The magnitude and direction, against the electric field, can be explained on the basis of the momentum balance. At weak magnetic field strengths even supersonic drift velocities are found. The charge flux carried by the ions is about five percent of the net arc current. For small flows, the ionized fraction of the gas supply approaches 100%. The neutral particle density outside the cathode consist of a fraction drifting with a large velocity out of the cathode and a fraction of cool background atoms. The change of the ratio of these fractions with increasing distance to the cathode causes the average neutral particle drift to decrease very rapidly. Finally, an analysis of the overall cathode power balance is given.


Discrete event simulation (DES) is a method for digitally replicating the behavior and performance of real-world processes, systems, and facilities. DES is widely applied in manufacturing, logistics, healthcare, and military domains. In some cases, DES method is insufficient. On one hand, the simulation must be disassembled into subsystems and then distributed on a multiprocessing environment to enhance the simulation performance. On the other hand, to expand current functionality and prevent future application development, a set of interacting simulations is required. In this project, the IEEE high-level architecture (HLA) standard mechanisms are adopted to solve the interoperability problems between heterogeneous components. Time synchronization between federates is essential to have all DESs running in parallel. In this paper, we present a distributed simulation framework designed to assist decision-makers in making the best decisions and prioritizing the adoption of Lean tools and techniques.


The main pillars of the insurance management are market share, financial strength and return for stockholders' capital. To increase the volume of business is a natural target for the management of an insurance company, but that may cause a need of new capital for solvency requirements and consequently a reduction in profitability is likely to occur. An appropriate risk analysis is then to be carried out on the company, in order to assess appropriate strategies, among these reinsurance coverage are extremely relevant. At that regard risk theoretical models may be very useful to depict a risk-return framework and in this paper some results are emphasized for the insurance risk management analysis in case different reinsurance strategies are pursued.


The aims of this study are: (a) To analyze the income of rice farmers in Kaloloa Village, Samaturu District, Kolaka Regency; (b) To analyze the strengths, weaknesses, opportunities, and threats in Manage Village, Samaturu District, Kolaka Regency, and (c) To study the rice marketing strategy in Kaloloa Village, Samaturu District, Kolaka Regency. This Research will be conducted in November 2019 in Kaloloa Village, Samaturu District, Kolaka Regency. The population in this study were all rice farmers in Kaloloa Village, Samaturu District, Kolaka Regency, which amounted to 13 rice farmers. The sample in this study is part of the number and characteristics possessed by the population. In this study, the sample for internal factors consisted of 13 rice farmers, and the sample for external factors consisted of 3 consumers. Analysis of the data used in the Analysis of the Principal Opportunity Point (BEP) used to determine the strategy. This study shows that rice farmers in Kaloloa Village have an average production of 4,146 with a selling price of Rp. 4,500/Kg. So farmers' income is IDR 91,471,900 / season or equivalent to an average of 7,036,300. per season. Meanwhile, the total production is 20,025, with an average of 4,146 per hectare.


The Paramyxovirinae currently are organized in three genera: the paramyxovirus genus (including Sendai virus [SeV], human parainfluenza virus type 1 [hPIV1], and human and bovine PIV3); morbilliviruses [e.g., measles virus and the distemper viruses]; and rubulaviruses (e.g., mumps virus and simian virus 5 {SV5}]). The first rubulavirus P gene sequence determined correctly was that of SV5. This yielded the surprising result that there was no single open reading frame (ORF) large enough to code for the SV5 P protein. mRNA transcribed from cDNAs that were exact copies of the SV5 P gene could be translated into the shorter V protein encoded by the 5' proximal ORF, but not into the longer P protein. Paramyxovirus RNA synthesis is restricted to the cytoplasm, and these viruses fend for themselves in all aspects of mRNA synthesis. Given that they formed their poly (A) tails by the unusual mechanism of polymerase stuttering, this mechanism was immediately suggested as one that could also account for the unusual G insertions. Experimental evidence in favor of a stuttering mechanism came from work with SeV, a member of the remaining paramyxovirus genus. SeV mRNAs made in vitro with purified virions contained the same pattern of G insertions as those found intracellularly, indicating that the process was carried out by viral gene products.


Serious economic crimes and violations of economic, social and cultural rights have often been neglected in criminal proceedings and/or reports of truth commissions following economic transitions or armed conflict. Although economic crimes have often resulted in a substantial loss of profit to economies and societies at large, they have neither been widely nor effectively prosecuted. Central- European and the Balkan region are not exception to this rule. However, as argued in the article, from Nuremberg on, there have been attempts and successful examples of prosecuting war profiteering cases. Even quite recently, the International Criminal Court's prosecutor called for such a prosecution to be conducted before the ICC. The study focuses on criminal responsibility for severe economic offences committed in transitional periods, as well as on establishing serious economic criminal offences as crimes under international law. it explores legal and social preconditions under which serious economic offences may be characterized as crimes under international criminal law.


The utility model relates to lighting technology and discloses a gesture control LED lighting device. The gesture control LED lighting device comprises an LED light source module, an AC-DC power module, a control module and a driving module and further comprises a gesture acquisition module, wherein a direct current output terminal of the AC-DC power module is connected with the driving module and the control module to provide power for the driving module and the control module, an output terminal of the driving module is connected with the LED light source module, a control terminal of the driving module is connected with an output terminal of the control module, the driving module drives the LED light source module according to a PWM signal outputted by the control module, the gesture acquisition module is connected with the control module to recognize gesture motion in an acquisition area, and a corresponding control signal is generated to modulate the PWM signal outputted by the control module. The gesture control LED lighting device has properties of more control convenience and randomness, and relatively rich control functions.


Abstract This paper presents some experimental results on the corrosion durability of cracked reinforced concrete beams made with plain mortar and strain hardening fibre-reinforced cementitious composites (SHFRCCs) containing polyethylene and steel-polyethylene hybrid fibres. All beams are subjected to cyclic wetting and drying using water containing 3% sodium chloride (NaCl). In addition, an external potential is also applied to the reinforcement to accelerate the corrosion. Corrosion of steel bars is monitored through a pair of sensors attached to the reinforcing bar in each beam. Test results show that beams containing SHFRCC material exhibited better corrosion protection than that of plain mortar beams. Among all specimens, beams containing hybrid steel-polyethylene fibre-reinforced SHFRCC exhibited the best corrosion protection.


We present DaMuEL, a large Multilingual Dataset for Entity Linking containing data in 53 languages. DaMuEL consists of two components: a knowledge base that contains language-agnostic information about entities, including their claims from Wikidata and named entity types (PER, ORG, LOC, EVENT, BRAND, WORK_OF_ART, MANUFACTURED); and Wikipedia texts with entity mentions linked to the knowledge base, along with language-specific text from Wikidata such as labels, aliases, and descriptions, stored separately for each language. The Wikidata QID is used as a persistent, language-agnostic identifier, enabling the combination of the knowledge base with language-specific texts and information for each entity. Wikipedia documents deliberately annotate only a single mention for every entity present; we further automatically detect all mentions of named entities linked from each document. The dataset contains 27.9M named entities in the knowledge base and 12.3G tokens from Wikipedia texts. The dataset is published under the CC BY-SA license at https://hdl.handle.net/11234/1-5047.


Trade union funds are the basis and guarantee for various activities in public institutions. It is of great significance to constantly enhance the vitality of trade unions and the competitiveness of public institutions to continuously improve the management and use of trade union funds, thus giving full play to the role of trade union funds to better serve workers. This paper analyzes the management and use of trade union funds in the present situation and proposes several measures for improvement.


The fourth industrial revolution has created many challenges for records and information management. This chapter provides an overview of the field of records management and describes the fourth industrial revolution and its impact. Further, it identifies several challenges to the profession of records manager, such as the effect of cloud computing, big data, mobile devices, and financial and ethical concerns. The author investigates how records managers can keep up to date with the changes in their profession by training and continuing education opportunities. Finally, the author discusses some possible solutions to the many challenges records managers face so that they can do their jobs effectively.