A parallel block-based adaptive mesh refinement (AMR) scheme is developed and applied to the prediction of the structure of non-premixed axisymmetric methane-air laminar diffusion flames. The parallel solution-adaptive algorithm solves the system of partialdifferential equations governing two-dimensional axisymmetric compressible laminar flows for reactive thermally perfect gaseous mixtures. A finite-volume spatial discretization procedure is used to solve the conservation form of the mixture continuity, momentum, and energy equations and species mass fraction equations on body-fitted multi-block quadrilateral mesh. The compressible formulation can readily accommodate large density variations and thermoacoustic phenomena. A local preconditioning technique is used to remove numerical stiffness and maintain solution accuracy for low-Mach-number, nearly incompressible flows. Limited piecewise linear solution reconstruction and Riemann solver based flux functions are used in the evaluation of inviscid fluxes and a centrally weighted secondorder discretization procedure is adopted for determining the viscous fluxes. A flexible block-based hierarchical data structure is used to facilitate mesh adaptation according to physics-based refinement criteria. The data structure also enables efficient and scalable implementations of the algorithm on multi-processor architectures via domain decomposition. Numerical results are discussed for co-flow laminar diffusion flames. The validity of the parallel AMR approach and the ability of the mesh adaption scheme to resolve fine-scale features of laminar flames is demonstrated.


Persuasion studies how a principal can influence agents' decisions via strategic information revelation --- often described as a signaling scheme --- in order to yield the most desirable equilibrium outcome. Recently, there has been a large body of algorithmic study of designing optimal public signaling schemes, a.k.a., public persuasion, which however is rifle with computational intractability results. In this paper, we design efficient and tight algorithms for public persuasion, and focus on a fundamental multi-agent persuasion model with no inter-agent externalities and binary actions introduced by Arieli and Babichenko. En route, we develop new algorithmic techniques which may be of independent interests.
First, we prove that optimal public persuasion is fixed parameter tractable. Our main result here relies on an interesting connection to a basic question in combinatorial geometry: how many cells can $n$ hyperplanes divide $R^d$ into? We use this connection to show a new characterization of public persuasion, which then enables efficient algorithm design. Second, we relax agent incentives and show that optimal public persuasion admits a bi-criteria PTAS for monotone submodular objectives and this approximation is tight. To prove this result, we establish an intriguing "noise stability" property of submodular functions which strictly generalizes the key result of Cheraghchi et al., originally motivated by applications of learning submodular functions and differential privacy. Finally, motivated by automated persuasion implemented as software, we consider relaxing the equilibrium concept of the model to coarse correlated equilibrium. Here we use a sophisticated primal-dual analysis to establish the polynomial-time equivalence between optimal public persuasion and the combinatorial problem of directly maximizing the sender's objective minus any linear function.


Using a treatment due to Bendow, Gianino and Tzoar (1) in which the electric field of a cw gaussian beam in a nonlinear waveguide is given utilizing the paraxial approximation, it is shown that a bistable behavior can occur in a cylindrically simmetric nonlinear waveguide in which the dielectric constant has a parabolic behavior in the radial direction.


Proline and betaine increased the thermostability of NAD-isocitrate dehydrogenase (EC 18.104.22.168) and of NAD-malate dehydrogenase (EC 126.96.36.199) when mitochondria isolated from pea leaves (Pisum sativum L.), wheat leaves (Triticum aestivum L.) and cauliflower buds (Brassica oleracea L.) were heated. Potassium chloride and choline chloride also increased the thermostability of isocitrate dehydrogenase in the three species, but their effects on malate dehydrogenase varied. Protection was found with both intact and disrupted mitochondria, indicating that it was not dependent on an osmotic effect. Proline and KCl also prolonged membrane integrity, as measured by impermeability to NAD+, during heating of pea leaf and cauliflower bud mitochondria. Phenylalanine reduced the thermostability of isocitrate dehydrogenase, indicating that protection is not a general solute effect.


All papers published in this volume of Journal of Physics: Conference Series have been peer reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing. • Type of peer review: Double-blind • Conference submission management system: https://sites.google.com/view/nanomat-2020 • Number of submissions received: 168 • Number of submissions sent for review: 146 • Number of submissions accepted: 63 Acceptance Rate (Number of Submissions Accepted / Number of Submissions Received X 100): 43.15% • Average number of reviews per paper: 2 • Total number of reviewers involved: 52 • Contact person for queries: Dr. Prashant B. Kharat Department of Physics, Vinayak Vidnyan Mahavidyalaya email@example.com


Designed by star architect of Moshes Safdie, Raffles City Chongqing includes a total of 6 mega high-rise towers 250 to 380 m tall, a sky conservatory, a 5-storey high shopping mall and a 3-storey basement car parking. Located at the confluence of the Yangtze and Jailing Rivers, the site for the project is imbued with a significance that is immediately symbolic, both as a sign of Chongqing's important past and as a vivid indicator of the city's thriving present and future. The design for the project to be situated at this gateway takes as its governing idea the image of powerful sails upon the water. The outer facades of the project's eight towers ? the transparent surfaces that will face the water to the north ? are meant to recall a fleet of ancient Chinese ships, with their huge rectangles of white canvas filled by the wind. This is a 1.13 million m2 mega scale integrated project of office, retail, hotel, service residence and high-end residence with the transportation hub and traffic circulation at various levels of the project. This paper presents the multi-dimensional hybrid design, engineering and construction of this mega scale project. The innovations and the cutting-edge technology used in this project are introduced and discussed benchmarking the design and construction of the skyscraper cluster in a major city like Chongqing of China.


This paper analyses the influence of external factors that affect the decision-making process in the selection of telecommunications engineering studies. Particularly, we have studied the influence of factors related to the generation of expectations about the studies. A survey was conducted on a sample of 701 male and female telecommunications engineering students. The results show the existence of a direct relationship between the choice of telecommunications studies in non-vocationally oriented students and their expectations of finding a job more easily, getting higher salaries and more prestige. On the other hand, non-vocationally oriented students show similar academic performance to that of vocationally oriented students.


Objectives Men are almost two times more likely to die by suicide than women, yet little research has focused on what is required to prevent suicide among men. This paper aims to investigate what factors interrupt suicidal behaviour in men, and to examine differences according to known suicide risk factors. Setting Australia. Participants 251 Australian men aged 18 years and over who had made a suicide attempt 6–18 months prior to completing the survey. Outcomes The survey canvassed the language men use to describe their depression and suicidality, warning signs, barriers to accessing help and what is needed to interrupt a suicide attempt. ORs and χ2 were used to test for differences by age, geographic location and current depression severity. Results Of 299 men screened and eligible to participate, 251 completed all or part of the survey. Participants identified different words and warning signs for depression compared with suicidality. The most commonly endorsed barriers to accessing help were not wanting to burden others (66%) and having isolated themselves (63%). Men overwhelmingly endorsed 'I thought about the consequences for my family' as the factor which stopped a suicide attempt (67%). 'I need support from someone I really trust and respect' was also strongly endorsed. There were few differences by age, region or depression severity. Conclusions Participants were able to identify signs, albeit often subtle ones, that they were becoming depressed or suicidal. Similarly, most were able to identify active strategies to interrupt this downward spiral. Men wanted others to notice changes in their behaviour, and to approach them without judgement.


Teacher's mental health plays a very important role in the promotion of education and teaching quality,students' healthy development and teachers'own life quality.On the base of the research review of mental health of teachers in Mainland China in the latest 20 years,this paper gives an overview of research methods,research content and maintenance strategies of teachers' mental health,and major factors which influence teachers'mental health,analyzes the existing problems of the study of teachers'mental health at present and takes a view of the future research in this field.


Power-Packer desired a way to create more insight into their procurement spend. To this end a model was designed to produce a spend analysis. Desired data was identified, then transformed into correct forms and errors were extracted. Using this data a dynamic visual dashboard was created with which the firm can actively produce information based on past data providing them with more insight into their procurement spend. With the provided model it will be possible for them to recreate the model periodically to maintain current insight.


This paper presents a state feedback controller design for a gantry crane. The controller is designed via pole placement in a Linear Matrix Inequality (LMI) region. Firstly, a stabilization condition which constrains the closed-loop poles of the system to be located in an LMI region is formulated in form of linear matrix inequalities (LMIs). The stabilization conditions guaranteed the system stability and gives satisfied transient performance. Based on the formulated stabilization conditions, a state feedback tracking controller is proposed for trolley position tracking and swing angle control of the gantry crane system. The performance of the proposed controller was investigated via simulations. The simulation results showed the proposed control scheme reduces the maximum payload oscillation by 48.28% when compared to PID control Scheme.


Energy has assumed the most important role in shaping transport policy. The paramount goal is to bring about energy savings in the short and long terms without significant adverse effects on mobility, economic growth or life styles. However, strategies for energy conservation have to be based on thorough understanding of travel demand determinants, land use patterns and attitudes of people towards mobility and modes. A plan of research is outlined which would enable a systematic, comprehensive and dynamic study of travel demand and energy efficiency to be undertaken. Effects of alternative fiscal, technological and regulatory policies as well as growth assumptions on short and long term energy consumption can be assessed using this approach (a).


Specimen‐driven intraoperative assessment of the resection margins provides immediate feedback if an additional excision is needed. However, relocation of an inadequate margin in the wound bed has shown to be difficult. The objective of this study is to assess a reliable method for accurate relocation of inadequate tumor resection margins in the wound bed after intraoperative assessment of the specimen.


The existing ways of braking of electric motors, comparison of the same ways among themselves are described, methods and technical decisions, used for an electric power effective utilization, including, research of a generating mode in a hoisting and transport and railway economy are resulted. The description of the concrete technical decision allowing rationally to use the electric power and to apply in a hoisting-and-transport and railway economy, including, in multiimpellent installations is resulted.


The rejection time of skin homografts was measured in rabbits previously sensitized by one intradermal injection of homologous blood platelets which had been carefully prepared free of leukocytes. The graft rejection time was determined by gross inspection and based on the onset of definite signs of graft breakdown.

In the platelet sensitized rabbits, the skin homografts from the platelet donors ("specific" grafts) were rejected significantly earlier than in nonsensitized animals in 42 per cent of the experiments. The homografts from animals other than the platelet donors ("nonspecific" grafts) were rejected sooner than normal in only 10 per cent of the experiments.

The results were interpreted as demonstration that blood platelets contain histocompatibility antigens.


In a world where organizations are being inundated with data from various sources, analyzing data and gaining actionable insights in real-time has become a key service differentiator. Over the last few years, several stream processing frameworks have been developed to address the need for large-scale, real-time analytics. A crucial challenge in these environments is the complexity of configuring, managing and deploying long-running streaming applications. Operators must carefully tune these systems to balance competing objectives such as resource utilization and performance. At the same time, they must also account for external shocks such as unexpected load variations and service degradations.
 In this demonstration, we show how operators can maintain healthy streaming applications without manual intervention while still meeting their performance objectives. We use Dhalion, an open-source library that sits on top of the streaming application, observes its behavior and automatically takes actions to keep the application in a healthy state. In particular, through various Dhalion policies that are configured by the attendees, we demonstrate how a streaming application can meet its performance objective by automatically configuring the amount of resources needed at the various application stages. We also demonstrate Dhalion's modularity and extensibility that greatly simplifies the process of developing new policies which address different application requirements.


Let d be a positive integer and Λ be a collection of partitions of d of the form (a1, …, ap), (b1, …, bq), (m1 + 1, 1, …, 1), …, (ml + 1, 1, …, 1), where (m1, …, ml) is a partition of p + q − 2 > 0. We prove that there exists a rational function on the Riemann sphere with branch data Λ if and only if max(m1, …, ml) < d/GCD(a1, …, ap, b1, …, bq). As an application, we give a new class of branch data which can be realized by Belyi functions on the Riemann sphere.


The resolution of N-AC-DL-Phe catalyzed by aminoacylase in the micro-aqueous phase was studied.Aminoacylase showed high catalytic activity and its activity was improved with the increase of lgP.The optimum temperature,water content and pH were 64℃,3.2% and 7.0,respectively in the isoamylol.


UML (Unified Modelling Language) is one of method to analyze the business process and model the business process in the specific notation. The UML model very helpful in coordinating the development of the information system. Retail industry is the ubiquitous industry because this industry do not need of huge capital dan specific academic knowledge although if the industry size grow up, it will need more more capital dan more specific knowledge. One of the resources which the need of every industry including the retail industry is information. To produce valid information, on time and reliable it will need the information system. Good plan make good information system. UML help in the planning process, specifically in the modeling the system. The UML model for retail industry can be use to produce good information system if correctly implemented.

Keywords: UML , Retail industry , Information system


Rooted stem cuttings of Ilex crenata Thunb. 'Rotundifolia' were grown in a controlled-environment growth chamber. Root-zone temperatures were controlled with an electric system. Shoot carbon exchange and root respiration rates were determined in response to root-zone temperatures of 28, 32, 36, and 40C for 6 hour·day -1 for 7 days. Photosynthesis was decreased by root zones ≥ 32C, while root respiration in- creased with increasing root-zone temperature. Decreased photosynthetic rates were not due to increased stomatal resistance. Reduced shoot and root growth has been reported for many species in response to high root temperatures (Gur et al., 1972; Johnson and Ingram, 1984). Decreased photosyn- thetic rates and increased root respiration contribute to such growth reduction. Johnson and Ingram (1984) reported reduced photo- synthetic rates in pittosporum (Pittosporum tobira Thunb.) after 6 months at supraopti- mal root-zone temperatures. Szaniawski and Kielkiewicz (1982) found that maintenance respiration was greater at supraoptimal root temperatures and this was related to in- creased root respiration. The temperature at which increased res- piration and decreased photosynthesis result in no net gain in carbon is termed the tem- perature compensation point (TCP) (Levitt, 1980). As the temperature increases above the TCP, carbohydrate reserves are depleted. Starvation induced by high temperatures could contribute to reduced plant growth and yield depression (Chen et al., 1982). The exis- tence of a TCP in response to supraoptimal root-zone temperatures has never been re- ported. Therefore, this study was conducted to determine root respiration and shoot car- bon exchange rates for Ilex crenata 'Rotun- difolia' exposed to supraoptimal root-zone temperatures for 1 week. Plant material. Stem cuttings of 'Rotun- difolia' holly were taken on 19 Mar. 1985 and rooted directly in white cone-shaped containers (21 × 4 cm tapering to 1 cm) that had 20, 0.5-cm-diameter holes equidistant around the length of each cone-shaped con- tainer to increase air exchange when mea- suring root respiration. The cone-shaped containers contained milled pine bark amended with 1.77 kg of a micronutrient


Two mathematically equivalent problems are solved exactly and in terms of elementary functions. A penny-shaped crack in a transversely isotropic elastic space is interacting with arbitrarily located point forces, applied in such a way that the tangential displacements outside the crack vanish. The problem of finding the tangential stress produced by such loading is solved exactly and in closed form. The second problem is that of interaction of an arbitrary point force inside the transversely isotropic elastic half-space and a flexible punch. The method of solution is based on the previously published results of the author. The results are of fundamental value, since they effectively give the Green's functions for solving any relevant problem of interaction.


The ability of a metal-reducing bacterium to microbially reduce vitamin B12 was determined to expand our understanding of the role vitamin B12 plays in the transformation of halogenated compounds in microbial systems. The subsequent transformation of chlorinated methanes catalyzed by this microbially-reduced vitamin B12 was then evaluated. When incubated in the presence of Shewanella alga strain BrY and an electron donor, the microbial reduction of vitamin B12a to B12r was observed as a shift in the vitamin B12 spectrum. In treatments containing vitamin B12 and an electron donor but without BrY, the predominant species was vitamin B12a. The introduction of BrY into the system resulted in the production of vitamin B12r. The transformation of carbon tetrachloride (CT), chloroform (CF), and dichloromethane (DCM) was examined in batch systems containing vitamin B12, Shewanella alga strain BrY, and an electron donor. Transformation of both CT and CF was observed, while no significant change in the DCM concentr...


Intellectual capital for companies, particularly manufacturing firms in the third millennium can be considered as a competitive advantage. The purpose of the research is to examine the role of innovation capital in the creation of value for business organizations. Intellectual capital (IC) disclosure has been receiving an increasing amount of attention among the companies around the world such as Australian companies, Italian companies and others. This is due to the new economy driven which is knowledge-based economy where value creation become one of the crucial issues in the world and tends to be based on intangible rather than tangible assets. In this study, a questionnaire was distributed among manufacturing companies have tried to collect statistical information . Questionnaire was divided between manufacturing firms and financial operations managers.The result shows that a company's IC in general has a The significant positive impact on its financial and market performance.


Two species ofdormice occur in Britain, one native ( Muscardinus avellanarius) and one introduced (Glis glis). The latter is localised, but increasing and is often a pest. The former has suffered a long- term decline in numbers and distribution and is now fully protected. Detailed studies ofthe ecology and conservation requirements of Muscardinus increasingly show the value ofthis species as a bio-indicator ofhabitat quality and integrity, with encouraging signs that its occurrence will be monitored systematically as a means ofassessing conservation re quirements in the wider countryside.


Background Cholesterol is essential for growth and maintenance of mammalian cells. It is stored as cholesteryl esters by the enzymes acyl-CoA:cholesterol acyltransferases 1 & 2 (ACAT 1 & 2) (Sterol O-acyltransferase 1 & 2; SOATs in GenBank). ACAT1 blockade (A1B) in macrophages ameliorates various pro-inflammatory responses elicited by lipopolysaccharides (LPS) or by cholesterol loading. In mouse and human brains, Acat1 expression dominates over Acat2 and Acat1 is elevated in many neurodegenerative diseases and in acute neuroinflammation. However, the possible effects of ACAT1 blockade in neuroinflammation, regulated by mediators such as Toll-Like Receptor 4 (TLR4), has not been studied. Methods We conducted LPS-induced acute neuroinflammation experiments in control vs myeloid specific or neuron specific Acat1 knockout (KO) mice. Furthermore, we evaluated LPS-induced neuroinflammation in the microglial cell line N9 with or without pre-treatment of the small molecule ACAT1-specific inhibitor K-604. Biochemical and microscopy assays were used to monitor inflammatory responses and the fate of TLR4. Results In vivo studies revealed that Acat1 inactivation in myeloid cell lineage, but not in neurons, markedly attenuated LPS-induced activation of various pro-inflammatory response genes in hippocampus and cortex. Studies in cell culture showed that pre-incubating cells with K-604 significantly ameliorated the pro-inflammatory responses induced by LPS. In cells acutely treated with LPS (for 30 min), pre-incubation with K-604 significantly increased the endocytosis of TLR4, the major transmembrane signaling receptor that mediates LPS-dependent acute neuroinflammation. In cells chronically treated with LPS (for 24-48 hrs), pre-incubation with K-604 significantly decreased the total TLR4 protein content, presumably due to enhanced trafficking of TLR4 to the lysosomes for degradation. For ex vivo evidence, we isolated microglia from adult mice, and found that in mice without LPS stimulation, myeloid Acat1 inactivation altered cellular distribution of TLR4; in mice with LPS stimulation, myeloid Acat1 inactivation decreased the cellular content of TLR4. Conclusion Blocking ACAT1 in mouse microglia alters the fate of TLR4 and suppresses its ability to participate in pro-inflammatory signaling cascade in response to LPS.


Actin filaments and microtubules control the shape of cells and organize their contents. The proteins that form these cytoskeletal polymers were identified and isolated decades ago—actin in 1942 (1) and tubulin in 1968 (2)—but we still argue about some of their basic properties. New work from Niedermayer et al. (3), however, puts us on the right track, or more properly back on the right track, to understanding how actin filaments fall apart. After years of study, how is it still possible for otherwise reasonable people to disagree about how actin filaments and microtubules assemble and disassemble? The shortest answer I can think of has two parts: (i) the details matter, and (ii) the experiments are hard. The details matter because small differences in the rate, mechanism, or geometry of polymer assembly and disassembly produce cytoskeletal networks with different architectures. Ultimately, we want to understand how cells manipulate such basic biochemical properties to produce different cytoskeletal structures with different biological functions. How, for example, does one cell construct a 3D pseudopod that pushes forward the plasma membrane; a linear stress fiber that pulls on cell adhesions; and a contractile ring that splits the cell in two—all from actin filaments? The experiments are hard, in part, because cytoskeletal polymers are constructed from large numbers of weak, noncovalent interactions, and they are dynamic, sometimes even ephemeral structures. To study assembly and disassembly of cytoskeletal polymers, we require techniques that maintain their native structure: techniques that often push technical boundaries in both biochemistry and physics. It is not surprising then, that the work of Niedermayer et al. represents the joint effort of two groups, one led by biochemist Marie France Carlier and the other by physicist Rheinhard Lipowsky.


The detection, transmission and the effect of Xanthomomas campestris pv. campestris (Xcc) in the physiological quality of broccoli seeds were evaluated. The seeds were obtained from inoculated field plants ('Baron', 'Florida', 'Hana Midori Sakata', 'Precoce Piracicaba de Verao', 'Ramoso Santana' and 'Sabre' genotypes) with the bacterium. For the seed pathogen detection the semi-selective medium were used: starch for xanthomonads (SX) agar, nutrient starch cycloheximide antibiotic agar (NSCAA) and basal starch cycloheximide antibiotic agar (BSCAA); the bacteria seeds transmission percentage was evaluated using sand and test tube. The physiological seed quality was evaluated by the standard germination and vigor tests: the accelerated aging, speed of emergence, seedling growth and seedling dry weight. The semi-selective medium NSCAA was more efficient to detect Xcc from broccoli seeds; there was not significant difference among genotypes regarding the percentage of bacteria transmissed by seeds percentage; although, Xcc can be disseminated by seeds, it did not affect both seed germination and vigor.


Paludrine, atebrin, and sulphamerazine neither prevented nor cured infections with Leucocytozoon simondi in ducklings, nor did they have any noticeable effect on the course of the infections. Paludrine failed to cure an established infection of Leucocytozoon sakharoffi in a crow. The extensive 'tissue stages' of these parasites probably explain the negative results.


Objective
To explore the clinical effect of long-term mild hypothermia therapy on high-grade aneurysmal subarachnoid hemorrhage (aSAH).

Methods
A total of 58 patients with high-grade aSAH were retrospectively analyzed who were treated with long-term mild hypothermia at Department of Neurosurgical Intensive Care Unit (ICU), Xuanwu Hospital, Capital Medical University from March 2015 to January 2017. Among them, 24 cases were treated with microsurgical clipping and 34 with interventional endovascular embolization. Follow-up study was carried out through outpatient clinic visit or telephone with the modified Rankin Scale (mRS) score after hospital discharge.

Results
In 58 patients, the duration of long-term mild hypothermia therapy was 5-14 days with an average of 7.0±4.4 days. Cardiac arrhythmia occurred in 37 (63.8%) patients, hypotension in 50 (86.2%), deep venous thrombosis in 8 (13.8%), gastrointestinal motility disorder in 54 (93.1%), stress ulcers in 8 (13.8%), pneumonia in 30 (51.7%) and acute respiratory distress syndrome in 4 (6.9%) patients. Cerebral vasospasm was reported in 28 (48.3%) patients, chills in 21 (36.2%), coagulation dysfunction in 17 (29.3%), stress hyperglycemia in 15 (25.9%), hypoalbuminemia in 13 (22.4%), catheter-related infection in 6 (10.3%) and delayed cerebral ischemia in 10 (17.2%) patients. There were 8 (13.8%) cases of death reported during treatment. Univariate analysis showed that high-grade Hunt-Hess grades (Ⅳ and Ⅴ) and cerebral vasospasm were the risk factors for death during treatment of long-term mild hypothermia (all P <0.05). A total of 48 patients were followed up for 3-6 months with an average of 4.3±1.9 months. Among them, 56.5%(26/46) achieved favorable outcome and 43.5% (20/46) reported unfavorable results. Among the patients with poor outcome, 6 died and 14 were moderately or severely disabled.

Conclusion
Long-term mild hypothermia therapy could improve the prognosis of patients with high-grade aSAH.

Key words:
Subarachnoid hemorrhage; Intracranial aneurysm; Hypothermia, induced; Treatment outcome; Prognosis


Since the reform in economy and opening policy in China, the small and medium enterprises of our country developed rapidly, and played a decisive role in keeping the speed and health of national economy developing, satisfying the social demand, optimizing industrial division, promoting technical innovation and providing employment. While nowadays there are some barriers in loaning, which are concerned greatly by the society


Wastewater effluent disposal is a challenge in Moroccan rural area. Wastewater treatment is the only suitable solution to overcome these environmental constraints. Technology such as Multi-Soil-Layering (MSL) system is one of the most appropriate solution for the treatment of wastewater for small communities in rural areas. The MSL system overcomes many of the deficiencies of conventional soil treatment systems such as large land requirement clogging and low Hydraulic Loading Rate (HLR). The MSL systems are composed of Soil Mixture Blocks (SMB) arranged in a brick-like pattern and surrounded by Permeable Layers (PL). To investigate the efficiency of MSL systems in relation to HLR differences and the fluctuations in the wastewater contamination levels, three MSL pilot plants were alimented continuously by domestic wastewater, were constructed in three 36×30×65 cm plastic boxes, with different HLR of 250, 500 and 1000 l/m2/day. The main removal rates of Biochemical Oxygen Demand (BOD5) and Chemical Oxygen Demand (COD) were higher at higher HLR. However, the kinetic rate constant of the MSL process implemented under Moroccan conditions is 130 d-1 at 25°C.


The status quo and the development process of transmission channel of power grid relay protection in Inner Mongolia Baotou area is introduced.Several optimal solutions are put forward from two aspects of facilities and equipment,and software configuration.And suggestions of improving the optical fiberas,the quality of the tail fiber connection head welding quality and the 2 Mbit/s connection,strengthening communication and coordination with relay protection workers,rationally making use of the allocation of fiber multiplexing channel,are carried out to ensure relay protection signal transmiting quickly and reliably,and the safe and stable operation of power supply network in Baotou area.


Objective To study the induction of IL-6 on expression and activity of tissue factor (TF)in peripheral blood monocytes(PBMCs).Methods rhIL-6 100 ng/L and rhIL-6 100 ng/L+ rhIL-6 MoAb 10μg/L were used respectively to stimulate the PBMCs for 24 h,PBMCs without any stimulation as control group,to study the changes of antigen content,mRNA expression and the ac- tivity of the TF.Results The antigen content,mRNA expression and activity of TF were increased significantly in 100 ng/L rhIL-6 group as compared with rhIL-6 100 ng/L+rhIL-6 MoAb 10μg/L and control groups(P<0.01).Conclusions rhIL-6 can induce the increase of antigen expression,activity and mRNA expression in PBMCs,and these effects can be suppressed successfully by rhIL-6 MoAb. This study demonstrated that there was potential relations between cytokines and thrombogenesis, which may play an important role the pathogenesis of chronic rejection.


I believe that military colorectal surgery is a national treasure. Our country is at war, and a major burden of the current conflict has fallen to our military members and their families. As described in the article on military practice in this issue of Clinics, military surgery is under siege and needs to be protected and supported. To become an advocate and promoter of military colorectal surgery, consider the following:

Try to find ways to showcase our military members. Rather than just sitting in the audience at our national or regional meetings, they deserve the podium. We need an affirmative action program for our military members. There ought to be a portion of the program of each American Society of Colon and Rectal Surgeons (ASCRS) meeting for presentations by the military. There ought to be more members from the military on committees. Although many of the military members are early in their career, they should be offered the opportunity to serve as officers for ASCRS and the American Board of Colon and Rectal Surgery as soon as possible. Perhaps a Military Liaison Committee could be formed or an annual military dinner could be a part of ASCRS. Again, I emphasize that many leaders of our specialty have served in the military but were never fully allowed to lead until they left the military. We ought to allow these sorts of leaders to bloom while yet in uniform. Military members continue to be an invisible force in ASCRS, one that deserves to be tapped and encouraged.

If you teach in a colorectal fellowship program, try to recruit a member of the military as a fellow.

If offered, please accept the opportunity to serve as a consultant. In this role you can elevate the level of knowledge and expertise of military physicians by teaching them better practices, new techniques, and so forth. In a very real way, you will be serving your specialty and your military.

When you see our military members at meetings, please thank them personally for their contributions and the sacrifices of their families.

Our military surgeons are representing our specialty while serving our country. They have earned and deserve our thanks and support.


Presented is the integrated analysis of interpretation of SVSL (Side-View Seismic Location) data describing the time-spatial distribution of fracturing of geological formations in various oil-and-gas fields and geodynamic test areas. Based on numerous data established are general regularities of time and spatial variation of the open fracturing of geological formations. These regularities are used to construct the models of geological interpretation of 3D and 4D distribution of fracturing mapped by SVSL seismic method to solve various applied problems of oil-and-gas geology and ecology.


Abstract Irradiation with ultraviolet (UV) energy was investigated to assay cadmium, copper, lead, and zinc by anodic stripping voltammetry (ASV) in amino acid parenteral nutrition (PN) solutions. Sample digestion by UV irradiation showed the best performances to liberate the metals from the samples (metal recoveries between 90% and 102%) in comparison with classical oxidative wet digestion methods. The best UV digestion condition was obtained with 1:10 diluted PN samples irradiated during 10 h at 90±3°C with the addition of one aliquot of 50 µL concentrated H2SO4 and repeated additions of 50 µL 30% (v/v) H2O2 at each 60 min irradiation interval. By using the UV digestion procedure cadmium, copper, lead, and zinc were simultaneously assayed in commercial amino acid PN solutions by ASV. The metal concentrations ranged between 1.3 to 4.4 for cadmium, 2.9 to 40.8 for copper, 4.4 to 16.8 for lead, and 1.4 to 208.5 for zinc. The ASV method correlated well with atomic absorption spectrometry measurements to assay the investigated analytes in amino acid PN samples after the UV digestion.


A 30-year-old man presented for advice regarding a benign naevus. He gave an incidental history of tingling and pain on his palms within minutes of contact with water, lasting approximately 30 min. Warm water triggered the symptoms more rapidly than cold water. His soles were not affected. Mild axillary and palmar hyperhidrosis was reported. Sweating on his palms after exercise could trigger the symptoms. He was otherwise fit and well, with no upper ⁄ lower respiratory or gastrointestinal symptoms. There was no history of atopy or other medical problems, and he was not on any medication. Examination revealed a 70-kg man with normal palms and soles. Immersion of his hand in water produced symptoms in 75 s with visible flesh-coloured papules (Fig. 1). Appearance reverted to normal after 20 min. Longer immersion produced symptomatic lesions of longer duration, up to 35 min. Oral antihistamines were of no benefit.


1. A process for preparing a compound of formula (I), a salt or monohydrate by treatment with a compound of formula (IV) a compound of formula (V) in the reaction mixture, and then dissolved the compound of formula (I) is treated with an acid to form a salt of the compound of formula (I), which precipitates from a solution containing dissolved compound of the formula (I) .2. A method according to claim 1 obtaining monohydrate compound of formula (I), wherein the salt of the compound of formula (I) is then treated with an aqueous basic solution to precipitate the monohydrate compound of formula (I) .3. A method according to claim 2, wherein the monohydrate of the compound of formula (I) is deposited at a temperature of from 35 ° C to 45 ° C.4. A method according to claim 2 or 3 for preparing a compound of formula (I), in which the monohydrate is dried under reduced pressure until until a compound of formula (I) .5. Process according to one claim 1, wherein the solution containing the dissolved compound of the formula (I) and the precipitated salt of formula (I) compound is the reaction mixture, or is a separate solution of the compound of formula (I), obtained after isolation of the compound of formula (I) smesi.6 from the reaction. The method of claim 1, wherein the acid generated In situ in the reaction mixture after the formed compound of formula (I), by adding to the reaction mixture and the protic substance kisloty.7 precursor. A method according to claim 6, wherein the acid is generated in situ in the reaction mixture after the formed compound of formula (I), by adding to the reaction mixture of an alcohol and atsilhlorida.8. The method of claim 1, wherein the alcohol is ethanol and the acid chloride is atsetilhlorid.9. The method of claim 1, wherein the compound


The La0.7-xTixMg0.3Ni3.5(x=0.00,0.05,0.10) hydrogen storage alloys were prepared by magnetic levitation melting under Ar atmosphere,and the effects of Ti on electrochemical properties of the alloys were studied systematically.X-ray diffraction(XRD)analyses showed that the alloys are mainly composed of LaNi5,LaMg2Ni9 and La2Ni3 phases.When x=0.10,TiNi3 phase appears.The cell volumes of LaNi5,LaMg2Ni9 and La2Ni3 phase decrease with the Ti content increasing.Electrochemical investigations showed that the maximum discharge capacity of the alloy electrodes are 370 mAh/g(x=0.00),331 mAh/g(x=0.05) and 252 mAh/g(x=0.10),respectively.The anodic peak potential of the cyclic voltammograms curve shifts to negative with the Ti content increasing,which means that the adding of Ti make the oxidation reaction of electrodes occur more easily.


This study investigated whether perceived goal support from family and friends may moderate the relationship between academic self-efficacy and motivational outcomes among early adolescent students recruited from a low-middle socio-economic status(SES) background school in Turkey (N = 319, X ¯ age = 13.13, SD = .80). Self-report questionnaires included measures of academic self-efficacy, perceived family and friend support, and academic and career motivations. Academic self-efficacy and perceived support from family related positively to both types of motivation. Children who perceived lower family support benefited more from the positive effects of self-efficacy on motivations, whereas children with higher family support seemed to gain less (or not gain at all) from self-enhancing functions of self-efficacy. Same findings were found for peer support, but only when family support was excluded from analyses. Findings implied the need to study larger family and peer contexts under which self-efficacy beliefs may be more or less effective on motivation.


The Institute of Physics is very large; it is much larger than any of the national physics organisations in the rest of Europe. One reason for this is clear.


Ozet: This study aims to investigate the views of different groups involved in enforcing, teaching, and adopting IFRS in Jordan concerning the different factors influencing de facto compliance with IFRS and whether the introduction of the OECD corporate governance principles improved such compliance. This was achieved by carrying out face-to-face interviews. It was also believed that face-to-face interviews would enable the researcher to estimate the degree of awareness among national investors regarding the level of disclosures that must be provided by companies listed on the stock exchanges of their jurisdiction, and the concept of corporate governance. The outcome of the conducted interviews revealed that the major barriers to full compliance with IFRS disclosure requirements in the Amman Stock Exchange (ASE) are: low non-compliance costs, inadequate qualification of accounting practitioners, low demand for more disclosure by investors, management resistance, and the lack of relevance of all the requirements under IFRS to the economic development stage of the scrutinised capital market. The impact of the introduction of corporate governance codes in the scrutinised context on improving de facto compliance with IFRS is not clear. Additionally, the results enhanced the assessment of the applicability of the Western theoretical foundations to the Arab emerging capital markets.


Context: The diagnosis of polyneuropathy may be challenging at the early stages of the disease. Despite electromyography (EMG) efficacy in the establishment of polyneuropathy diagnosis, in some cases, results are dubious and neurophysiologists may implement additional techniques to ensure that conduction is affected. Aims: The aim of the study was to evaluate motor-evoked potential (MEP) characteristics in children with acute inflammatory demyelinating polyneuropathy (AIDP). Settings and Design: The study was conducted at a pediatric research and clinical center for infectious diseases. Subjects and Methods: Twenty healthy children (7–14 years old) without signs of neurological disorders were enrolled as controls. Thirty-seven patients (8–13 years old) with AIDP were enrolled as the main group. EMG and transcranial magnetic stimulation (TMS) were performed on the 3rd–7th days from the onset of the first symptoms. Statistical Analysis Used: Descriptive statistics and Student's t-test were used. Bonferroni method was applied to implement appropriate corrections for multiple comparisons. Results: Significant differences between children with AIDP and controls on latencies of both cortical and lumbar MEPs were registered. Cortical MEP shapes were disperse in 100% of the cases and lumbar MEPs were disperse in 57% of the cases. Conclusions: Diagnostic TMS on the early stage of the AIDP in children may be implemented as the additional tool. The main finding in this population is lengthening of the latency of cortical and lumbar MEPs. Disperse shape of the lumbar MEPs may be used as the early sign of the acute demyelization.


The informal colony refers to a group of people forming naturally. According to the characteristics of students and aerobics teaching and using theories of psychology and education,the author designs a series of teaching experiments. The aim is to make the informal colony formed by students freely play an important role in the aerobics teaching exercise and it has turned out to be good through the experiments.


Effect of TCCM on prednisone acetate induced osteoporotic rat was evaluated by single photon absorptiometry.24 male Sprague-Dawley (SD) rats at 3 months of age and weighing 345~347g were used in this study and randomly divided into control,hormone-TCCM groups.The hormonal group was fed prednisone acetate (4.5mg/kg,ig)twice a week and the hormone-TCCM group given TCCM(5g/kg,ig)6days per week besides prednisone acetate.After 90 days,single photon absorptiometric measurement were made on femurs of three groups of rats.Results showed that bone mineral density(BMI) in proximal,middle and distant segments of hormonal rats was respectively decreased by 12.4%(P<0.05),13.9%(P<0.05) and 11.9%(P<0.05)ub comparison with control,and the BMD in proximal,middle and distant segments of hormone-TCCM rats was separately increased by 25.9%(P<0.01),34.4%(P<0.01)and 30.6%(P<0.01)when compared with hormonal rats. These data suggested that TCCM could prevent prednisone acetate-induced osteoporosis in rats.


A kind of manufacturing process for housing precast concrete with exterior decoration was developed based on practical housing industrialization project.According to the characters of housing precast concrete,the designe and manufacture method of mold was discussed,a prefabricated technology by which exterior decoration could be integrated with concrete was introduced,the steam curing system and conditions were determined,and a brief description of the products stacking measures was given.


Laila Nuranna Cervical cancer continues to be a wide spread women health problem throughout the world, especially in developing country like Indonesia.1 Reports from Indonesian government hospitals show that cervical cancer makes up 28% of all cancer cases in women.2 In Indonesia, data from various academic hospitals until 2007 showed that cervical cancer is the first ranked malignancy in women followed by breast cancer, ovarian cancer, cancer of the uterus, vulva, and vagina.3 Since 2008, breast cancer is the leading cancer among Indonesian women, based on pathology data.4 The majority of cervical cancer cases (about 70%) are diagnosed when they are already at an advanced stage (stage IIb or more).5 This is an astonishing fact, considering that preventive measures toward cervical cancer are very possible due to several factors. First of all, the etiology of cervical cancer has already been established as persistent HPV infection with a natural history that takes a long time for the development of cancer. Furthermore, there are already several well-known and cost-effective methods for screening. Nowadays, the availability of HPV vaccine should further reduce the burden of cervical cancer. Unlike other types of cancer, screening efforts in cervical cancer is of high importance and is the main approach in the prevention of cervical cancer. Therefore, the focus for cervical cancer prevention should be on screening, which ideally should cover 70-80% of population at risk. One important factor in mass screening program is achieving screening coverage, which can achieve 70-80% of women at risk.6 Lack of screening program for cervical cancer in Indonesia is the main cause for most patients being diagnosed at an advanced stage. Pap smear is a popular screening method. Unfortunately, it is difficult to be used as a basic method for mass program because this method requires a level of infrastructure such as cytologic laboratory including the human resource needed, such as pathologists and cytotechnicians. As a result, cytology-based screening is largely unavailable and therefore likely to have little impact on the disease. Another alternative method for cervical cancer screening is VIA (Visual Inspection with Acetic Acid) where the cervix is washed with 3-5% acetic acid and then inspected by the naked eye for detecting any color changes in the form of acetowhite epithelium that signifies the cervix being at the pre-cancer lesion phase. VIA has potential advantage over traditional screening techniques in low-resource settings. There is immediate feedback of test results to the patient and, more importantly, treatment can be provided immediately after the test. We defined a positive test for VIA as either abnormal or cancer, as shown by acetowhite epithelial lesions and other visual markers of (pre) cancerous lesions of the cervix.7 VIA can be a breakthrough screening method enabling women in low resource setting like Indonesia to have the opportunity to be screened. The Indonesian Ministry of Health adapts a cervical cancer screening program with VIA test. This method is non-invasive, simple, and low-cost. This VIA program has already been employed in several areas in Indonesia. Currently, almost all provinces in Indonesia, 33 of 34 provinces, has been exposed to the See and Treat Program or SVA (Single Visit Approach) for Cervical Cancer Prevention. Recent review estimates that the sensitivity of this method is 66-99% and the specificity is 6498%.8 Another study found that it is more sensitive but less specific than the conventional Pap smear.9 In this era of digital camera, the procedure of VIA can be documented which we call Documentation on VIA (Do-Via). This documentation of VIA is inspired from cervicography, a form of magnified photographic inspection of the cervix that has been shown in the past to be a reliable method of detecting cervical cancer precursor Indones J 62 Laila Obstet Gynecol


China is currently in a rapid urbanization phase, and road traffic accidents occur frequently, with vulnerable road users often being easily injured. Traditional road traffic safety research often focuses on environmental and structural safety issues or considers human factors as the cause of accidents. This study organized 30 vulnerable road users to travel in a quadrangular road area in the Wudaokou area of Beijing, collected language data from the subjects for analysis, and attempted to apply schema theory and the perceptual cycle model from the field of cognitive psychology to analyze the perception and decision-making processes of vulnerable road users, thus discovering accident risks in the traffic environment and their underlying causes from the perspective of vulnerable road users. The study found that factors such as disorderly placement of shared bicycles, food delivery vehicles occupying the road, damaged road infrastructure, and unreasonable road design affect traffic safety and order, and proposes targeted improvement suggestions.


The paper summarizes global advances of research in grapevines for drought tolerance. It covers the negativeinfluence of drought stress on photosynthesis, vegetative and reproductive growth; and also the prospective on the trend of furtherresearch for water stress resistance by integrating the physiological process into biological mechanism were put forward.


In this study, we first present a coherent optical orthogonal frequency division multiplexing (CO-OFDM)with polarization division multiplexing (PDM)and 64-order quadrature amplitude modulation (QAM). We then proposed an efficient channel estimation method based on minimum mean square error(MMSE)to further improve the performance of the system. The results show that a CO-OFDM system use of PDM, high order QAM technology, and our improved MMSE channel estimation algorithm can significantly improve the transmission performance and built higher speed rates, large capacity and long haul distance transmission via optical networks.


Background and Purpose—Further research is needed to better identify the methods of evaluating processes and outcomes of stroke care. We investigated whether achieving 4 evidence-based components of a care bundle in a Scotland-wide population with ischemic stroke is associated with 30-day and 6-month outcomes. Methods—Using national datasets, we looked at the effect of 4 standards (stroke unit entry on calendar day of admission [day 0] or day following [day 1], aspirin on day 0 or day 1, scan on day 0, and swallow screen recorded on day 0) on mortality and discharge to usual residence, at 30 days and 6 months. Data were corrected for the validated 6 simple variables, admission year, and hospital-level random effects. Results—A total of 36 055 patients were included. Achieving stroke unit admission, swallow screen, and aspirin standards were associated with reduced 30-day mortality (adjusted odds ratio [95% confidence interval]: 0.82 [0.75–0.90], 0.88 [0.77–0.99], and 0.39 [0.35–0.43], respectively). Thirt...


Given a family $\mathcal{F}=\{A_1,\dots,A_s\}$ of subsets of $\mathbb{Z}_n$, define $\Delta \mathcal{F}$ to be the multiset of all (cyclic) distances dist$(x,y)$, where $\{x,y\} \subset A_i$, $x \neq y$, for some $i=1,\dots,s$. Taking inspiration from a Euclidean distance problem of Erd\H{o}s, we say that $\mathcal{F}$ is Erd\H{o}s-deep if the multiplicities of distances that occur in $\Delta \mathcal{F}$ are precisely $1,2,\dots,k-1$ for some integer $k$. In the case $s=1$, it is known that a modular arithmetic progression in $\mathbb{Z}_n$ achieves this property (under mild conditions); conversely, APs are the only such sets, except for one sporadic case when $n=6$. Here, we consider in detail the case $s=2$. In particular, we classify Erd\H{o}s-deep pairs $\{A_1,A_2\}$ when each $A_i$ is an arithmetic progression in $\mathbb{Z}_n$. We also give a construction of a much wider class of Erd\H{o}s-deep families $\{A_1,\dots,A_s\}$ when $s$ is a square integer.


Aplastic anaemia (AA) is a rare immune‐related adverse events (irAEs) after immune checkpoint inhibitors (ICIs) administration with poorly understood incidence and outcomes. We analysed an electronic health record database of 52 303 ICI‐treated patients and found 77 (0.15%) cases of AA, with a median onset of 126 days (interquartile range, 58–363 days). The most used treatment for AA was systemic glucocorticoids 60 (77.9%) and 32 (41.6%) patients were able to resume ICI within 1 year. Patients diagnosed with AA had a steep decline in overall survival (OS) within the first 120 days; when compared to propensity score‐matched patients without AA, they had a significantly worse OS (hazard ratio 1.72, 95% confidence interval 1.19–2.50; p = 0.003).


Aspects of practical assessment such as question design and management of the assessment are discussed. Reference is made to some of the problems and to the possibilities for innovation which are possible as a result of implementing practical assessment of the kind required by the GCSE examining groups.


Existing methods for measuring vapor pressure are too expensive or not quantitative enough for chemistry classes in secondary schools. Our method measures the vapor pressure inside a bubble trapped in a graduated microtube made from a disposable 1-mL glass pipet. Vapor pressures of water, methanol, and ethanol are measured over temperature ranges of 4-90 °C. The enthalpy and entropy of vaporization and boiling points, calculated using the Clausius-Clapeyron equation, agree well with published values. The vapor pressures of aqueous solutions of ethanol and methanol plotted against mole fractions of water give positive deviations from Raoult's law, but concentrations were identified from which molecular weights of the alcohols could be calculated. These molecular weights are not significantly different from published values. Sources of error in the method are analyzed. A procedure for use in secondary schools is outlined.


In the enlargement of fonts, fonts becoming enlarging or reducing targets are divided into rows and columns, and cost is calculated according to forming pixel patterns of every row and every column. In enlargement treatment, cost represents line segment quantity and a column or a row with small cost, and namely columns or rows with pixel arrays similar to line segments can not be enlarged easily. Besides, in reducing treatment, cost represents similar degrees among adjacent rows and columns, and columns or rows with similar pixel patterns near can become reducing targets in the priority. Because rows and columns of enlarging targets and reducing targets are determined according to the construction of pixels of fonts which become the enlarging targets and the reducing targets actually, natural enlarged and reduced fonts can be obtained. Besides, the enlargement and the reduction of fonts are used for the deformation of fonts.


On August 17, 2010, the Financial Accounting Standards Board and the International Accounting Standards Board jointly issued exposure drafts proposing a new accounting model for leases. This paper explains how a lessee would account for leases under this proposal.


This study identifies the various views on the baseball introduction in Korea as examining the existing studies. For this purpose, this study breaks down the views on the baseball introduction into view on the introduction in 1904, view on the introduction in 1905 and view on the introduction in 1907 found out the conclusions as follows. In Korea, since Na Hyung-Seong insisted the introduction of baseball in 1905, diverse studies quoted his opinion. Then, the view on the introduction of baseball in 1905 was the established theory. However, as examiningthe actual bases, Na Hyung-Seong quoted "history of Chosun Baseball" of Osima, but it was considered that on year was added(the 37th year of Meiji period=1904) during translation. And the view on the introduction in 1904 was appeared in "History of Chosun Baseball" written by Lee Gil-Yong, which was considered to be the first record on the Korean baseball history two years prior to Osima. Therefore, the baseball was firstly introduction for YMCA members in Korea by Phillip L. Gillett, the American missionary in 1904 in accordance with the examination up to now. However, to clarify the view on the baseball introduction in Korea, it is necessary to examine Gillett who introduced the baseball and exploit the data related to baseball activities among foreigners in Busan and Incheon opened from the end of 19th century, It will be the subject for the future studies.


The invention discloses a car window area identifying method and device based on sobel edge detection and belongs to the field of image processing. The car window area identifying method includes calculating gradient in the vertical direction by sobel gradient operator in the identifying area to obtain a horizontal edge image and gradient in the directions of 45 degrees and 135 degrees by oblique sobel operator to obtain a 45-degree edge image and a 135-degree edge image; determining upper and lower borders of a car window according to the horizontal edge image and left and right borders of the car window according to the 45-degree edge image and the 135-degree edge image. By the car window area identifying method and device based on sobel edge detection, interference resistance of identification of the car window is improved.


This study was to assess the nutritional quality and bioactive properties of black cumin (Nigella sativa L.) seeds and oil commonly found in the Chinese market. The results showed that black cumin seeds contain 5.02, 21.07, 39.02, 3.02, 6.01, and 25.86% moisture, crude proteins, crude fat, ash, fiber, and carbohydrates, respectively. It also contains substantial amounts of minerals, namely calcium, potassium, phosphorus, magnesium, sodium, iron, zinc, and copper. Glutamic acid (4.10 g/100 g protein) is the major amino acid of black cumin seeds. The major volatile components in black cumin seeds were thymoquinone (21.01%), o-cymene (18.23%), and β-thujene (17.22%). Cumin seed oil extracted by the soxhlet method contains high quantities of unsaturated fatty acids (UFA; 85.16%) and low amounts of saturated fatty acids (SFA; 15.02%). The major fatty acid of black cumin seed oil was linoleic acid (57.71%), followed by oleic acid (24.46%). The most prominent TAG of black cumin seed oils was oleoyl-dilinoleoyl-glycerol (OLL; 38.87%). In addition, the levels of α-tocopherol, β-tocopherol, γ-tocopherol, and total polyphenols in the black cumin seed oil were 25.59, 14.21, and 242.83 mg/100 g, and 315.68 mg GAE/kg, respectively, and possessed high antioxidant activity (DPPH IC50%, of 4.02 mg/mL). These findings demonstrate that black cumin seeds are nutritionally rich with high potential applications in the food, pharmaceutical, and cosmetic industries.


Bondowoso Regency is one of the fourth largest coffee producers in East Java. In 2020 the coffee area is 17,700 ha with a production of 10,285 tons consisting of Arabica coffee and Robusta coffee. However, when viewed in terms of quality and price, Arabica coffee has a better advantage than Robusta coffee, so that the people of Bondowoso Regency develop more Arabica coffee. Areas that have the potential to develop Arabica coffee agribusiness are in the Ijen Raung area. Currently, Arabica coffee farmers in the region have problems where the COVID-19 pandemic has caused a decline in Arabica coffee prices, sales and limited promotional events held by local governments. So that the income of Arabica coffee farmers in Ijen Raung decreases. This study aims to analyze the activities of sustainable Arabica coffee agribusiness development during the COVID-19 pandemic in Ijen Raung, Bondowoso Regency. The method used in this research is ISM analysis to produce appropriate and interpretable. The sampling method used experts with four experts. The analysis results show that the formulation of local government policies and monitoring and evaluation of policies are key factors needed in sustainable Arabica coffee agribusiness development activities during the COVID-19 pandemic in Ijen Raung Bondowoso Regency. © 2023 American Institute of Physics Inc.. All rights reserved.


The paper examines the spatiality of day-to-day social reproduction in middle-class Britain. We argue that the concept of spatiality should be extended to include analyses of the production of home space, the meaning of which has received only limited attention from geographers. The potential spatial organization of the various tasks which constitute day-to-day social reproduction is contrasted with their spatial form in two historical conjunctures in Britain. In both cases (and despite the possibility of alternative arrangements) this spatial form is home-based. Using middle-class childcare as our illustration, we account for the persistence of this spatial organization in contemporary Britain, emphasizing the importance of the spatially prescriptive nature of the dominant ideology of childcare and of cultures of domesticity. In turn, the spatial organization of middle-class daily social reproduction is shown to be (re)constitutive of 'home'.


In this work, a behavioral model of tubular wave couplers (TWC), whose use was recently included into automotive Standards for immunity verification of wiring harnesses in the frequency range from 400 MHz to 3 GHz, was derived. The model is based on scattering parameter measurements with the TWC mounted onto the calibration structure provided by the manufacturer, and the spurious effects related to such a fixture have been modeled and de-embedded from the measurement data. The proposed behavioral model allows physical insight into the TWC behavior (e.g., device directivity), and represents an important step for possible correlation of the TWC method with radiated susceptibility test procedures foreseen by the Standards.


An image processing apparatus collects volume data regarding an object, generates volume-rendered image data from the collected volume data, acquires a projection image of the object based on the volume-rendered image data at a position at which virtual illumination is emitted toward the object, and corrects the projection image by using at least one conversion function, thereby obtaining a result image.


Novel spatiotemporally complex nonlinear dynamics observed in a phase-conjugate optical feedback system are experimentally captured and classified using chaos bandwidth (~30 GHz), quantifying complexity via permutation entropy (> 0.9), and real-time frequency and temporal analyses.


In order to improve the quality and health safety of fermented milk, soya fermented by different lactic acid bacteria (LAB) was used. It was found that soya fermented by solid state (SSF) and submerged (SmF) fermentation can be used for the processing of innovative fermented milk, because the final product is enriched with soya proteins and LAB. Lactobacillus sakei in milk-soya samples, treated with submerged fermentation, was responsible as the strain for low active acidity (pH 4.62), high titratable acidity (99.0 T) and degradation of lactose (up to 4.18%) P ≤ 0.05, lower amounts of D(–) lactic acid isomers, biogenic amines and high acceptability of the final product. The results showed a possibility for innovations to use LAB, especially L. sakei, in soya fermentation and production of fermented milk products of valuable composition.


Objective To study the imaging features of malignant tumors of intra-abdominal testes.Methods The clinical presentation,computer tomography(CT),ultrasonography(US)and magnetic resonance imaging(MRI)features of 6 patients with malignant tumor of intra-abdominal testes proved by surgery and pathology were analyzed retrospectively.Results CT performed in 6 patients showed well-circumscribed soft-tissue masses with inhomogeneous enhancement in all cases.US in 4 patients showed well-circumscribed masses with inhomogeneous hypo-echogenicity.MRI in 1 patient showed soft-tissue mass with inhomogeneous intensity and enhancement.Retroperitoneal lymph nodes were detected in 3 patients.The pathological diagnosis of all patients was seminoma.Conclusion The malignant tumor of intra-abdominal testes has some imaging characteristics,the radiologist should raise to know it and play an important role in the diagnosis.


Säntti, J., Puustinen, M., & Salminen, J. (2017). Theory and practice in Finnish teacher education: a rhetorical analysis of changing values from the 1960s to the present day. Teachers and Teaching, 24(1), pp. 5–21. When the above article was first published online the order of authors was incorrect. The correct order is as follows: Janne Säntti, Mikko Puustinen and Jari Salminen. The author apologize for this error.


to explain how the fiction came about. His attitude is throughout cautious and critical. His verdict ' Livy was preoccupied with writing, not with the affairs of the day or even with antiquarian research ' (p. 5) must perhaps be qualified by a reference to P. Fraccaro's insufficiently known paper Livio e Roma (1942, now in Opuscula 1, 81). The mere fact that Livy did not indulge in antiquarianism is significant: he was chiefly interested in the late Republic.


Pulsed magnetic fields greater than 100 koe and of microsecond duration are reported here to be readily producible in millimeter‐diameter coils supplied by energy storage units of only several joules capacity. Demonstrative experiments are described which show the magnetic‐state transitions of a 20‐μg specimen of MnAs near 90 koe, the shift in transition temperature when the specimen and coil are subjected to hydrostatic pressures up to 850 atm, and the reversal of magnetization of a 0.5‐μg iron cube from which all reverse nuclei were driven presumably.


Through the huge success of spectroscopic single-fiber, statistical surveys of the Local Universe in the last decade, it has become clear, that an authoritative observational description of galaxies will involve measuring their spatially resolved properties over their full optical extent for a statistically significant sample. The Calar Alto Legacy Integral Field Area Survey (CALIFA) survey was designed to provide a first step in this direction. This survey is obtaining spatially resolved spectroscopic information of a diameter selected, statistically well-defined sample of ∼600 galaxies in the Local Universe (0.005 < z < 0.03) using the PMAS/PPAK IFU, mounted on the Calar Alto 3.5m telescope (Sanchez et al. 2012). CALIFA has been designed to allow the building of two-dimensional maps of the following quantities: (a) stellar populations: ages and metallicities; (b) ionized gas: distribution, excitation mechanism and chemical abundances; and (c) kinematic properties: both from stellar and ionized gas components. The optical wavelength range is covered from 3700 to 7000 A, using two overlapping setups (V500 and V1200), with different resolutions: R ∼850 and R ∼1650, respectively. CALIFA is a legacy survey, intended for the community. The reduced data will be released, once the quality has been guaranteed. CALIFA published its first Data Release (DR1, http://califa.caha.es/DR1) in November 2012, providing freely to the community fully reduced and quality control tested datacubes of 100 objects in two spectral resolutions (Husemann et al. 2013). The galaxies in DR1 already cover a wide range of properties in color–magnitude space, morphological type, stellar mass, and gas ionization conditions. This data offers the potential to tackle a variety of open questions in galaxy evolution using spatially resolved spectroscopy. The release also includes software interfaces and tools that allow easy access and friendly visualization to the data.


This article proposes a fast and accurate expansion-iterative method for solving second kind linear Volterra integral equations. The method is based on a special representation of vector forms of triangular functions (TFs) and their operational matrix of integration. By using this approach, solving the integral equation reduces to solve a recurrence relation. The approximate solution of integral equation is iteratively produced via the recurrence relation.


Objective. Alteration in the vaginal flora has been associated with adverse pregnancy outcomes. The objective of this study was to examine the impact of changes in individual microflora on genital immunity among low‐risk pregnant women in early pregnancy. Design. Cross‐sectional study. Setting. Large, tertiary care, academic hospital clinic. Population. Low‐risk women were enrolled prior to 14 weeks' gestation. Methods. Women were included if they had no medical or previous obstetrical complications, were non‐smokers, had no sexually transmitted infections and no intercourse in the last 48 hours. Consenting women underwent speculum examination for collection of vaginal culture and Dacron swabs for cytokine analysis. Semi‐quantitative vaginal cultures were performed in a reference laboratory. Main Outcome Measures. Concentrations of immune mediators were compared in the presence of various organisms. Concentrations were converted to multiples of the median to standardize the values of each mediator. Regression analyses were performed to control for race. Results. We enrolled 47 women. The frequencies of genital microorganisms were: H2O2‐producing lactobacilli (70%), Ureaplasma urealyticum (66%), Gardnerella vaginalis (45%), anaerobic non‐pigmented Gram‐negative rods (ANPGNR, 40%), anaerobic pigmented Gram‐negative rods (APGNR, 17%). After adjusting for race and body mass index, interleukin‐1β, interferon‐γ, tumor necrosis factor‐α and granulocyte macrophage‐colony stimulating factor were increased in the presence of G. vaginalis, ANPGNR, and APGNR. There was no consistent impact on the other markers of immune activation. Conclusion. The presence of individual species impacts genital immunity among low‐risk pregnant women. Perturbations in genital immunity could partially explain heterogeneity in adverse pregnancy outcomes.


Sodium telluride, prepared by heating tellurium with Rongalite in aqueous sodium hydroxide, easily reduces aromatic nitro compounds to the corresponding amines in good yields. The reduction can be carried out using a catalytic amount of tellurium, since sodium telluride is readily regenerated in the presence of excess Rongalite.


We will present the development of a rich internet application for remote visualization, collaborative annotation, and automated analysis of high-resolution, high-throughput biological images. With our application, high-resolution images in various formats (e.g. from whole-slide scanning devices) that are usually too big to fit into traditional computer memory can be visualized at multiple resolutions in web clients through fully Javascript interfaces, caching mechanisms and distributed image tile servers. Our underlying relational data model allows to create projects which contain users with permission lists, images, ontologies with domainspecific terms, and layers of annotation geometries (e.g. polygons) drawn on top of original images. All project data are stored in a relational database and can be visualized and edited through the web interface, and they can also be retrieved or updated by third-party softwares through a RESTful API (two client libraries in Java and Python have been developed). In addition, we are integrating ImageJ/Fiji/OpenCV image processing routines and our generalpurpose machine learning algorithms to facilitate image annotation and quantification. At this stage of development, our application already delivers about one thousand whole-slide images (roughly 1.5Tb of data) and more than six thousand regions of interest were annotated by our collaborators in the context of ongoing studies on lung cancer and inflammation, and Zebrafish toxicology. Overall, the proposed web software is generally applicable and its methodological choices open the door for large-scale distributed and collaborative image annotation and exploitation projects. Acknowledgments: This work is funded by the research grant n°1017072 of the Walloon Region (DGO6).


This article proposes a high efficient zero voltage and current switching (ZVCS) based high frequency link three phase three level diode clamped inverter operated with Space Vector Pulse Width Modulation technique (SVPWM) with an optimized current controller by taking photovoltaic array as a source. The scheme is analyzed in different load conditions by using an optimized current controller. The optimum values of current controller are obtained by using a minority charge carrier inspired algorithm. In This article, two types of controllers have been analyzed and compared. The switching scheme and operation are implemented in MATLAB and simulation results shows the effectiveness, robustness of this technique used.


The authors show that Zipf's law can be understood only by a dynamical approach and that deviations from Zipf's law unveil physical properties of systems.


ABSTRACT Objectives : The purpose of this study was to estimate the antioxidant activity of water extract of Nelumbinis stamen (WNS) in GC-2 spd (ts) cells. Methods : we investigated the effect of WNS in mouse GC-2 spd (ts) cells by MTT assay. The protective effects of WNS against hydrogen peroxide-induced oxidative stre ss in GC-2 spd (ts) cells were examined by measuring cell viability. Lipid peroxidation levels and catalas e were measured. Results : WNS showed cell viability as 101.9, 108.9, 111.8, 125.8, 134.5 % in 2.5, 5, 10, 25, 50 ??g/ml concentrations, respectively. The protective effect of WNS concentration was 2.5 ??g/ml against hydrogen peroxide-induced oxidative stress in GC-2 spd (ts) cells. LPO were decreased significantly at 2.5, 5, 25 ??g/ml of WNS concentrations. Catalase activity was significantly incr eased at 2.5, 5 and 10 ??g/ml of WNS concentrations, respectively. Conclusions : In conclusion, WNS has antioxidant activities in GC-2 spd(ts) cells against oxidative stress.Key words : water extract of Nelumbinis stamen (WNS), GC-2 spd(ts) cells, Cell viability, LPO, Catalase


The article presents a method of validation the three-component microelectromechanical speed gyro which will later be used in the design of an automated navigation system working body of the machine-hexapod.


In this paper, cooperative multicast with the help of short-range data sharing is studied in the cognitive radio networks (CRNs). The original multicast data is split into many segments, and the transmission of each segment is divided into two stages. In the first stage, cognitive base station transmits each segment to the corresponding cooperative user, and in the second stage, the cooperative user decodes the received data and broadcasts it to other multicast users. Based on this transmission model, cooperative multicast is formulated as an optimization problem with the aim of maximizing the total transmission rate. Afterwards, we first propose a cooperative user selection strategy, which is meaningful when the multicast size is large, and then implement the resource allocation with dual translation and subgradient updating. The simulation results show that the proposed cooperative multicast scheme can achieve much higher spectrum efficiency than both conventional multicast scheme and multiple description coding multicast scheme.


Solid electrolytes have received considerable scientific attention and assumed important technological significance in recent years, due to potential practical applications in fuel cells, batteries, electrochromics, process control, sensors and environmental protection. Use of solid electrolytes for developing electrochemical gas sensors is a well established field with successful commercial applications related mainly to oxygen measurements. Discovery of new solid electrolytes have led to new areas of development and applications such as hydrogen monitoring. Applicability of solid electrolytes have also been extended to species which are not ionically mobile in the electrolyte by use of auxiliary phases. More recently, significant progress in sensing of molecular species such as CO2, SO2, SO3, NO, NO2, HCl, H2O and HF have been achieved by interfacing 2 or more electrolytes in electrochemical chains and/or by using auxiliary phases, semi-permeable coatings or in-situ catalysts to promote the desired electrode reactions.


Modern single space feeding systems for fattening pigs allow the detailed assessment of an individual animal's feeding behaviour. In an experiment involving 96 fattening pigs, the influence of deoxynivalenol (DON) contaminated feed (> 4 500 μg/kg DON) on the zootechnical performance and feeding behaviour was compared with a feed with low DON concentration (< 900 μg/kg DON), this served as the control group. Additionally, in separate treatments, two commercial mycotoxin binders were added to the DON-contaminated feeds to assess if an expected DON effect could be attenuated. The high DON content significantly (P < 0.03) reduced daily feed intake (500–600 g/day). The DON group showed 240 g less daily gain compared to the control with 728 g/day. Both mycotoxin binders were seen to additionally depress weight gain by approximately 65 g/day (P < 0.01). The treatment did not affect the individual feeding behaviour as assessed by daily visits to the feeder, feed intake per visit and the highest feed intake per visit per day. These were influenced only by the pig and its pen, indicating that the animals developed a distinct behaviour within their respective groups. Behaviour analyses of persistency and day-to-day variation showed that the persistency was reduced and variation was increased when DON without or with binder was present. The DON contents therefore seemed to lead to a more erratic and less consistent behaviour that remained dependent on the animal group.


Crowdsourcing has become an indispensable tool in the behavioral sciences. Often, the "crowd" is considered a black box for gathering impersonal but generalizable data. Researchers sometimes seem to forget that crowdworkers are people with social contexts, unique personalities, and lives. To test this possibility, we measure how crowdworkers (N = 2,337, preregistered) share a monetary endowment in a Dictator Game with another Mechanical Turk (MTurk) worker, a worker from another crowdworking platform, or a randomly selected stranger. Results indicate preferential in-group treatment for MTurk workers in particular and for crowdworkers in general. Cooperation levels from typical anonymous economic games on MTurk are not a good proxy for anonymous interactions and may generalize most readily only to the intragroup context.


It is well known that gravity and neutrino oscillation can be used to probe large extra dimensions in a braneworld scenario. We argue that neutrino oscillation remains a useful probe even when the extra dimensions are small, because the brane-bulk coupling is likely to be large. Neutrino oscillation in the presence of a strong brane-bulk coupling is vastly different from the usual case of a weak coupling. In particular, some active neutrinos could be absorbed by the bulk when they oscillate from one kind to another, a signature which can be taken as the presence of an extra dimension. In a very large class of models which we shall discuss, the amount of absorption for all neutrino oscillations is controlled by a single parameter, a property which distinguishes extra dimensions from other mechanisms for losing neutrino fluxes.


OBJECTIVE
We conducted this study to gain an insight into the experiences and views of practitioners of urut Melayu, the traditional Malay massage, which will be used in developing a preliminary framework of the urut Melayu process.

DESIGN
We adopted a qualitative study design. We carried out a total of five focus group discussions (FGDs) comprising 6-10 urut Melayu practitioners each.

LOCATION
We carried out three FGDs at the Traditional and Complementary Medicine Division, Ministry of Health and two FGDs at a district Health Clinic.

SUBJECTS
All participants of the FGDs were urut Melayu practitioners registered with the Ministry of Health. Three (3) FGDs comprised all females while two comprised all males. A total of 12 males and 24 females participated in the study.

RESULTS
We identified six themes from the study, namely, indications for urut Melayu, the urut Melayu technique, other treatments in conjunction with urut Melayu, outcome of urut Melayu, ethics of urut Melayu, and practitioners' source of skills and knowledge.

CONCLUSIONS
Urut Melayu is a unique form of massage carried out for various purposes. Although it is common belief that there are vast differences in the way it is performed from one practitioner to another, this study revealed that similarities do exist and there is potential to develop a standard framework for urut Melayu for regulation and training purposes.


The major trend toward vehicle electrification intensifies the need for increased battery energy densities. During the development of new electric vehicle battery technologies, it has become clear that thermal, mechanical, and electrochemical coupling effects play an important role in battery performance, degradation, and response to abusive conditions. The macro-homogeneous Dualfoil model, which solves ion transport and charge transfer dynamics, predicts the electrical response of a single small battery cell. However, when considering large cells or assembled battery modules and packs, inhomogeneity of electric potential and temperature throughout the cell volume becomes severe enough to impact battery performance. Cell expansion and contraction during charge/discharge cycles further increase such inhomogeneity, and the resulting potential and temperature imbalances cause non-uniform current distribution in the cell. Heavily cycled cell regions generate additional heat and stress, causing severe degradation in the performance and life of the battery. Given the strong coupling between thermal, mechanical, and electrochemical phenomena, it is imperative to integrate multiple physical models in the simulation of complete battery packs.
 In this work, a modified Dualfoil electrochemical model is coupled to a thermo-mechanical finite element solver to represent such multiphysics coupling effects. Outputs from the 3D thermo-mechanical solver, such as temperature and stress, are supplied as inputs to the Dualfoil model, which in return computes the electrochemical response and provides the local heat generation rate and Li intercalation induced volume change to the thermo-mechanical solver. Using this coupled multiphysics simulation framework, the impact of external mechanical loading under different charge/discharge profiles was investigated. The transient, non-linear behavior of internal variables, such as SOC, overpotential, and current density, during and after cycles, was obtained in the entire 3D battery pack domain. This information provides good insights for design and optimization of battery packs with high performance and long life time.


Introduction:
 The activation of NF-κB is the dominant process that correlates with the pathogenesis of diabetic cardiomyopathy (DCM). Recently, accumulating evidence shows that long noncoding RNAs (lncRNAs) play crucial roles in sustaining the NF-κB pathway. However, the underlying mechanisms remain unclear. In this study, we identified the upregulated expressed lncRNA NBR2 in adipocyte-derived exosomes (AdEXO) and investigated its regulatory role in diabetic myocardial fibrosis.

 Hypothesis:
 We hypothesized that AdEXO-NBR2 promotes diabetic myocardial fibrosis through regulating the IκBα/NF-κB pathway.

 Methods:
 We examined the effect of exosomes from diabetic (db/db) mice-derived adipocytes on ANG-II-induced cardiac fibrosis and function in non-diabetic (C57BL/6J mice). In the invitro study, HG (33mmol/L)-stimulated AdEXO were cultured with adult human cardiac fibroblasts (aHCFs). Differentially expressed lncRNAs in AdEXO were screened using lncRNA sequencing.

 Results:
 Intramyocardial injection of diabetic AdEXO in the non-diabetic heart significantly exacerbated myocardial fibrosis, as evidenced by poorer cardiac function and enhancer collagen deposition. Whereas administration of a exosomes biogenesis inhibitor mitigated cardiac fibrosis in diabetic mice. We found lncRNA-NBR2 is a common molecule significantly increased in diabetic AdEXO and HG-stimulated non-diabetic AdEXO. After four weeks of ANG II infusion, EXO-db/dbWT-injected mice displayed fibrosis in the heart. However, interestingly, mice receiving NBR2-deficient db/db-EXO showed a decrease in cardiac fibrosis. Similarly, AdEXO-NBR2 promoted aHCFs proliferation and transformation capabilities in vitro. Mechanistically, NBR2 was loaded to AdEXO by directly interacting with heterogeneous nuclear ribonucleoprotein K (hnRNPK). Subsequently, AdEXO-NBR2 was internalized by aHCFs and epigenetically downregulated IκBα expression by recruitment of hnRNPK/SETDB1 and increasing the H3K9 trimethylation level in the IκBα promoter, ultimately activating the NF-κB pathway.

 Conclusions:
 Our findings highlight a novel epigenetic mechanism of AdEXO lncRNA-mediated diabetic cardiac fibrosis and identify NBR2 as a therapeutic target of DCM.


The prevalence of mobile computing platforms and the Internet of Things applications has triggered a quest to evolve energy-efficient software systems. Thus, addressing energy efficiency at the architectural level is a booming topic of interest. By this paper, we aim to propose an energy-driven architecture that encloses the most relevant artifacts tackled throughout the software design to analyze energy consumption. Our approach combines the meta-modeling and the graph transformations to formalize the understudied system and to survey the energy consumption. The energy consumption analysis is held on different alternative solutions of software architecture in a precocious stage for design more energy-efficient applications.


Introduction Measuring weight is difficult to be carried out in bedridden people, with physical deformity or in emergency units. Under these circumstances, one option is to estimate the weight. Objectives The aim of this study is to propose and validate equations for estimating the weight of Brazilian adolescents based on anthropometric variables related to body weight. Methods The study was developed based on a database created from data collection of a primary project, which had information from 662 Brazilian adolescents (10 to 19 years old). Based on the variables sex, age (days), weight (kg), height (m) and neck circumference (NC) (cm), equations for estimating weight of adolescents were proposed. The formulas were proposed after performing multiple linear regression models and subsequently tested and validated using appropriate statistical tests, considering 99% confidence. Results Two formulas were generated, the "Rucco Formulas—Adolescents", one for girls: -131.63091 + (0.00209 × A) + (37.57813 × H) + (3.71482 x NC) and another for boys: - 15.2854 + (-0.00414 × A)+ (14.30315 × H2)+ (0.04888 x NC2). Statistical test (R2) indicated that the proposed formulas are suitable for estimating weight. Low values of REQM and high values of CCI (> 0.8) also reinforce the quality of the proposed formulas. Conclusions The current weight of adolescents can be estimated with adequate accuracy and precision using sex-specific "Rucco Formulas—Adolescents", generated from regression models using only three predictor variables.


The homology based 3-Dimensional structure prediction of calcium dependent protein kinase Isoform 1 From Cicer arietinum (chick pea) was carried out using bioinformatics tools. The CPK1 sequence on Protein BLAST analysis for homology search revealed 100 hits and Out which a few had significant E score (E <0.005) and better sequence similarity. Multiple sequence alignment analysis of CPK1 using MultAlin and HHpred showed above 90% similarities with protein sequences of Thermotoga petriphila (Hypothetical protein), Geobacillus stereothermophilus (1w91; 99.5%; E score=1.2 E-11), Thermoanaerobacterium saccharolyticum (1uhv; 99.4%; E score=2.9 E-11) and Bacillus stereothermophilus (1qw9; 98.5%; E score=4.9 E-6) from the PDB database. The secondary structure of CPK1 using PSIPRED VIEW revealed many helices, strands and coils in the protein structure. The tertiary structure prediction of CPK1 by MODELLER 8v2 showed a (s/a) 8 fold. The program VERIFY 3D assessed the quality of the predicted structure of CPK1 with acceptable scores.


The dominating effect of Wavelength Division multiplexed system is Four Wave Mixing (FWM).Channel crosstalk and performance degradation of the system can be induced in the multi channel systems by FWM. In this paper, we have simulated the effect of chromatic dispersion on FWM using equal channel spacing in terms input/output spectrum, eye diagram and bit error rate. Results show that the effect of FWM reduces with the increasing dispersion coefficient. And the suppression of FWM is achieved by placing the Optical Phase Conjugator (OPC) in the midway of the fiber optic link. It strongly suppresses the FWM signal by introducing the destructive interference between the first and second halves of the fiber optic link. Reconstruction of original signal can be achieved by placing another OPC at the end of the second fiber span. DWDM system with OPC can effectively suppress the Four Wave Mixing signal power.


As nonrenewable sources are depleting day by day and are creating environmental hazards due to their use, renewable sources are evolving as a preferred option in the world. Many countries have set up high targets of renewables. So that the energy production mix will not be compromised and the energy is easily available.The focus of the research is to simplify modelling of single phase system. Maximum power point has been implemented using fuzzy logic.


Teacher preparation programs need quality training courses that offer flexible, interactive alternatives to isolating online courses and classroom-based programs that limit students to a specific place and time. The HyFlex course design provides a solution by combining internet video instruction (such as Zoom), regular online learning, and face-to-face classroom experiences into one course where students can choose the method that best meets their individual learning needs and even alternate between methods throughout the course session. HyFlex aligns with learner centered instruction and offers a unique opportunity for educators to receive quality licensure courses. This article explores existing literature on the HyFlex course delivery method and discusses a case study done to examine student outcomes resulting from its use in a post-baccalaureate special education teacher licensure program.


This is the first of a set of three papers in the Journal that were to transform the study of drug antagonism (see also Schild, 1949, and Arunlakshana & Schild, 1959). At the time it was written, there was a pressing need for methods that would allow the effectiveness of drugs to be measured and expressed in a consistent and reproducible fashion. As Schild noted in his introduction, the requirement was particularly great for antagonists because of the multiplicity of methods then used and the lack of information about their reproducibility. In this important paper he proposed and validated a new measure of antagonist action, PA. The key principle is that the same submaximal response to an agonist is measured first in the absence of antagonist and then in its presence, using a greater concentration of agonist. This was an important departure from early attempts to quantitate drug antagonism by determining the reduction that the antagonist caused in the response to a standard application of agonist. The results of such measurements had proved rather irreproducible, not only from laboratory to laboratory but even between different preparations of the same tissue. Schild was always meticulous in his acknowledgement of the contributions of others, and he makes it clear that his new scale for the expression of drug antagonism was based on the work of Clark & Raventos (1937) who had already recognised the advantages of assessing the effectiveness of antagonists in terms of the multiple by which the agonist concentration had to be increased to overcome the effect of a certain concentration of antagonist. This factor was described as the dose rutio by Gaddum et ul., (1955). Schild extended the concept by suggesting that a useful index of the effectiveness of an antagonist would be the value of PA,, the negative logarithm of the concentration of the antagonist that reduces the effect of a multiple dose ( x ) of an agonist to that of a single dose. Here x is the dose ratio. Though this was to prove an important advance, the paper became a landmark at least as much because of its detailed description of how best to measure the action of antagonists and also because of its searching discussion of the pharmacological applications of such methods. Three points merit particular mention. 1 . Schild showed that pA values provided a means of quantifying not only the overall effectiveness of an antagonist but also some of the characteristics of its action, namely, its time dependence and its variation with concentration. It has to be appreciated that Schild defined pA as an experimentul measure of antagonist action, independent of theory. Hence pA increases with time following the application of an antagonist. Also, PA, values may or may not vary with the magnitude of the response measured depending on the antagonist's mechanism of action. Moreover, pA values can be calculated whether or not the antagonism is competitive (though their interpretation is much less certain for noncompetitive antagonism, as Arunlakshana & Schild were to discuss in 1959). It follows that the term pA, should not be regarded simply as another way of expressing the negative logarithm of the dissociation equilibrium constant for the combination of an antagonist with its binding site: this relationship holds only for reversible competitive antagonism, at equilibrium, as shown by Arunlakshana & Schild (1959). 2. The paper described in the greatest detail how the action of antagonists could be evaluated using the isolated guinea-pig ileum preparation, and the procedures that Schild introduced were to be widely adopted. His 'automatic assay apparatus' allowed tissues to be exposed to agonist at reg-