Objective: To obtain more information about frizzled6 gene and Frizzled6 protein,for further study on Wnt-Fz signaling pathway and the correlation between FZ gene and neural tube defects.Methods: Bioinformatics methods were used to analyze FZ6 gene structure,single nucleotide polymorphisms,protein secondary structure,protein interaction network,and multiple sequence alignment of Fz protein family.Results: FZ6 gene locates on the 8 chromosome of human (8q22.3-q23.1) and has full length of 33995 base pairs,encoding 706 amino acids;there are 8 SNPs in coding region,including 4 missense;the 10 members of Fz protein family are divided into four clusters,Fz3 and Fz6 in the same cluster;Fz6 protein has two conserved domains,but unlike other family members,it does not contain a C-terminal S/T-X-V motif;its secondary structure mainly consists of α-helix and coil.Conclusion we get more biological information about FZ6 gene and Fz6 protein by bioinformatic analysis,which is very useful for further research.


Constructing an n times n non-blocking wavelength router using n times n optical cross-connects may be impractical due to certain constraints such as the cost or space limitations. Moreover, in many cases the traffic requirements can be handled without a non-blocking router. In this paper, we study blocking wavelength routers constructed using x times x, x < n optical cross-connects without wavelength conversion. We find the set of rates that can be supported between the input and output fibers of a certain set of symmetric blocking routers. We propose a method to construct blocking routers to achieve any given supportable rate in this region for any given x


Millennium Specialty Chemicals (MSC) is one of the world's largest producers of terpene*-based fragrance and flavour chemicals. With products for the personal care industry, if you wash your clothes, brush your teeth, Clean your floors or chew gum - then you will probably have used our products and not even have known it. The company runs two production sites in the US. The main one is in Jacksonville, Florida and the other, a smaller site, is in Brunswick, Georgia. The small volume production facilities include both batch and continuous units such as reactors and distillation columns which make high value products using raw materials such as the by-products of pulp and paper mills. Millennium is a small company seeking the right level of automation for our needs and we do not "automate for automation's sake" - it needs to add value to our operations. Being small we also need to balance in-house skills with outside support. To help us to focus we use a set of industry best practices brought to us by organisations such as Breakthrough Process Consulting - a UK based consulting company, our vendors, and independent organisations such as the World Batch Forum and ARC. These help keep us on track and to learn from the mistakes of other companies who may have more resources able to tread paths that can ill afford to.


ABSTRACT Two early medieval jewelled crosses are preserved in the treasury of the Cathedral of Oviedo. The first, known as the Cross of the Angels, was donated by King Alfonso II in the year 808. The second, the so-called Cross of Victory, was given as a gift to the Cathedral by King Alfonso III in 908. The original function of these crosses remains unknown, as the early medieval sources are silent on the subject. Nevertheless, evidence suggests that the earlier of these two crosses was displayed on the main altar of the Cathedral of Oviedo before the twelfth century, while it seems likely that the second cross functioned as a processional cross. Around the turn of the twelfth century, the bishops of Oviedo began to develop a propagandistic programme using a series of old objects that were incorporated into new discursive contexts, in particular the corpus of texts redacted by Pelayo of Oviedo (1089–1153), consisting of the Liber Testamentorum and the Corpus Pelagianum. From this point on, the crosses became the stars of a series of legendary tales, whose enduring popularity has helped preserve these objects. This article reviews the historiographic process by which the first of these two crosses was transformed into acheiropoieton, and the second, into a Christian battle standard at the Battle of Covadonga.


Background and Design.-  Totally 36 patients who had undergone pyeloplasty operation for ureteropelvic obstruction in our clinic between 1986 and 1998 were evaluated retrospectively. Results.-  The mean age of these cases was 30,7 years, of which 12 were female and 24 male. Anderson Hynes technique had been undertaken in 30 patients, Foley Y-V plasty in 5, Culp DeWeered spiral flap in 1 patient. In all cases other than those who had undergone Foley Y-V plasty required nephrostomy and stend application. The development of severe wound infection requiring reoperation in 1 patient and a late fistula healing spontaneously in an other was observed. The mean duration of hospital stay was 9 days. Conclusion.-  In all cases an improvement had been noted when the findings of preoperative urography were compared with those taken 3 months after the operation. Atakan IH, Kaya E, Kaplan M, Alagol B, Inci O. The evaluation of our pyeloplasty operations.  Cerrahpasa J Med  2000; 31 (3): 140-143. * Anahtar Kelimeler:  Pyeloplasti, Ureteropelvik darlik * Key Words:  Pyeloplasty, Ureteropelvic obstruction


In recent years, a considerable amount of research has been devoted to the under-standing of the structural performance of single isolated stainless steel members. Not withstanding, advances related to the analysis of more complex stainless steel structures, such as frames, are scarce. On this basis, a comprehensive experimental programme on sway and non-sway austenitic stainless steel frames with slender and stocky rectangular hollow sections subjected to static loading was carried out at Universitat Politecnica de Catalunya. The paper presents the preliminary experimental results on one non-sway and one sway frame as illustrative of the experimental programme. A more in deep analysis of these frames will contribute to the appraisal of existing design rules for stainless steel, which are based on carbon steel, in terms of predicted ultimate capacities, plastic design and second order effects, considering the particular non-linear behavior and strain hardening for stainless steels.


The breakthrough cancer pain (BTcP) is defined as a "transitory flare of moderate to severe pain, interrupting mild background pain being controlled by chronic opioid therapy" (1) or as a "transient exacerbation of pain that appears in a situation of persistent pain otherwise stable" (2). The clinical features of BTcP vary from individual to individual and the underlying mechanisms are not always clear. BTP's clinical characteristics have been found to be mostly paroxysmal in onset, reaching maximum severity within 5 minutes (2-4), recurring in 4–7 pain episodes per day (1, 4, 5). The BTcP is normally a therapeutic challenge, and when treatment is inadequate or absent, can have a terrible impact on patients quality of life, reducing his or her ability to work and participate in other daily activities. Patients suffering from BTP feel poor and decreased satisfaction with overall pain control (6). Besides breakthrough pain may result in a number of other physical, psychological, and social problems (7). Really BTcP in patients further to be a significant clinical problem produces an increase in the economic burden for patients and the healthcare system (8). Also very often the poor management of this type of pain may reduce the estimate to the doctor. Despite the clinical relevance of BTcP in the context of cancer related pain, there is increasing evidence that its assessment and diagnosis is often poor and treatment suboptimal (9), and this type of pain remains largely lacunous in many aspects, including terminology, definition and epidemiology. BTP has been a topic of considerable semantic debate and subject of one of the major consensus meeting of an expert working group of the European Association for Palliative Care (2). In fact the term Breakthrough pain remained confusing for many European languages, because no translation existed (2). The expert working group of the European Association for Palliative Care suggested the use of a simpler term such as "transient" or "episodic" pain, as the English term "breakthrough" has no literal translation in many other languages. Although at present the term "breakthrough pain" remains widely and invariably used within the medical literature and other terms are confounding and unused in literature. Breakthrough pain is a spectrum of very different entities and it is still today classified as incident pain (IP) and spontaneous pain (SP) (10-12). Incident pain's episodes are related to an identifiable precipitant. IP is usually sub-classified into three categories, volitional IP is brought on by a voluntary act (e.g., movement, activity), non-volitional IP is brought on by an involuntary act (e.g., bladder spasm), and procedural pain is related to a therapeutic intervention (e.g., wound dressing) (13). In SP no identifiable precipitant can be related to the episodes. Based on the clinical features of BTcP it is recommended that it be managed with transmucosal rapid onset (ROO) formulations of fentanyl (oral or nasal). It is essential to consider that morphine sulphate immediate release, frequently used, does not show an efficacy profile superior to placebo first 45 minutes after, with pharmacokinetic characteristics inadequate to most of the episodes of BTcP and suitable only for the EUR. J. ONCOL.; Vol. 20, Suppl n. 1, pp. 11-12, 2015 © Mattioli 1885 Proceeding Master Class in Oncology


Embodiments of the present invention provides a highly accurate generation and use of the mold of the methods and processes for producing micro-optical elements such as microlenses. The master mold is generated using one of at least a gray scale techniques or direct write lithography, the master mold is produced, high-precision micro-optical contour of the is provided on the substrate or the resist layer. The generation of the secondary mold to be used from a variety of materials to fabricate the micro-optical element of high precision, may be using the master mold.


Realists agree that great powers balance the military power of rising powers, but there is little agreement regarding secondary-state responses to rising powers. First, there are differences regarding whether secondary states balance or accommodate rising powers. Second, there are differences among realists regarding the distinct roles of economic and military factors in secondary-state alignment policies. Third, some scholars argue that state alignments are not necessarily determined by realist variables, but can reflect preferences shaped by intentions, historical experiences, or cultural influences. This paper addresses these issues in balance-of-power theory. Its empirical focus is the impact of the rise of China on secondary-state alignments in East Asia. After examining the complex mix of China's military and economic reach in East Asia, it concludes that secondary-state behavior is sensitive to local variation in the great power capabilities and that secondary states tend to accommodate rather than balance rising powers. It further concludes that economic capabilities alone are insufficient to generate accommodation, so that the political-economy literature should reexamine cases of apparent secondary-state accommodation to economic dependency, sensitive to the presence of military vulnerability on the part these secondary states to proximate great powers. These conclusions suggest that there is nothing sui generis or culturally-determined in East Asian international politics and that realism can explain alignment behavior among East Asian states as well as it does among European states. Research on East Asia's response to China's rise that is sensitive to intra-regional variations in U.S. and Chinese military and economic capabilities also challenges assumptions of an emerging Chinese regional hegemony or of a costly region-wide U.S.-China competition.


This investigation contributes reflections about the legend of the Light of Yara, from historical perspectives, territorial location and mutations as contribution to cultural narratives and identities. Sprung up about Yara, settled in the current province of Granma, keeps your physical manifestation, although not the arguments and explanations on the motive of the starts of the light. In the first and second half of the xix century, the testimonies are notably different. When evaluating the historical available information appreciates a marked change of the arguments in the xix century. In the first half, the light has been in relation with a fire in the church of Yara; in the second, to patriotic criterions and for start-ups of xx century, with the birth of the republic and the need to emboss the patriotic values of the new state-nation. United to these changes in the arguments on the manifestation of the light, also ponders the complexity of the cultural narratives of the social actors that it have re contextualized the legend in the time.


In this paper, we prove the following theorems. If R is ring such that charK = 0, then there exist an integer k such that: (a) for every pair of finitely generated R-modules M and N; and (b) if M is a finitely generated R-module having a well-defined rank and (F.,φ.) is any finitely generated free resolution of M, then , ···, and ∀j≥d+1 where =


A connector and a cable capable of absorbing low-frequency electromagnetic waves when they are formed of a material containing a conductive nano material, and a magnetic metal material. Since the conductive nano material and a magnetic metal nanowire or magnetic nanoparticles, in comparison to only conductive nano material having a high permeability, low frequency electromagnetic waves can be absorbed and electrical interference between the various electric / electronic parts are kept to a minimum.


Low-Dose Cytarabine in Myelodysplastic Syndromes and Acute Leukemia A Comment E. Elio Cacciola F. Francesco Di Raimondo P. Patrizia Guglielmo G. Giuseppe Milone R. Rosario Giustolisi Elio Cacciola, MD, Francesco Di Raimondo, MD, Patrizia Guglielmo, MD, Giuseppe Milone, MD, Rosario Giustolisi, MD, Institute of Medical Semeiotic I and Hematology, University of Catania, Via S. Citelli No. 6, 1-95124 Catania (Italy) We have read with interest the paper of A. Inbal et al. [1] and we would like to make some comments. There are a few unclear data. The authors reported in table II that patient No. 2 had a granulocyte count of 5.98 × 10/1 before treatment with low-dose cytarabine (LDC) and a granulocyte count of 5.28 × 10V1 after treatment. It is also reported that patient No. 1 did not have any abnormal chromosomal pattern. Nevertheless, in the 'Results' and 'Discussion' sections they asserted that'... in 3 patients (No. 1, 2, 3) with refractory anemia (RA) normal peripheral blood was obtained after one course of treatment'. But patient No. 2 had before treatment with LDC a granulocyte count of 5.98 × 10/1 and of 5.28 × 10V1 after treatment; is this a mistake? Furthermore, the authors reported in the 'Discussion': '... therapy with LDC was associated with beneficial responses in 5 of the 8 patients, 3 of whom (namely the first three ones showed in the table) achieved normal peripheral blood counts'. However, patient No. 2 had yet prior to treatment a normal granulocyte count, whereas platelet count and Hb level were low. With regard to patient No. 1 the chromosomal analysis was normal (see table II), but in the 'Discussion' (p. 73) the authors reported as follows: 'In our 3 patients with refractory anemia (namely patients No. 1, 2, 3), despite excellent responses to cytarabine, the bone marrow metaphases remained 100% abnormal'. But if patient No. 1 had a normal chromosomal pattern before treatment, how could one explain 100% of metaphases abnormal? Is this a mistake? In addition, we would like to comment some suggestions of the authors with regard to the mechanism of action of LDC which, in our opinion, appears to be conflicting. They firstly reported that the LDC regimen results in inducing a suppression of the leukemic clone, so allowing the suppressed normal hematopoietic one to maturate. The authors later reported that the excellent response to cytarabine regards a differentiating effect on the leukemic clone, as demonstrated by the persistence of abnormal bone marrow metaphases. This could be the case in the patient with acute leukemia (even if one had a normal karyotype), but it is questionable in RA patients. In RA patients the percent of bone marrow blast cells is very small (5%); therefore, it is difficult to think that the myeloid matu-rative effect of LDC corresponds to a differentiative stimulus on 'leukemic clone' rather than on 'suppressed normal hemopoietic line'. The finding of a persistent abnormal chromosomal pattern after LDC does not seem enought to support this view because it might concern the persistence of residual leukemic cells. On the other hand, the


The loose, small zooecia of the cheilostome bryozoans have been discovered in the lowermost part of the La Meseta Formation on Seymour (Marambio) Island. They systemati− cally include the representatives of Beanidae Canu et Bassler, Catenicellidae Busk, Savi− gnyellidae Levinsen, and Calwelliidae MacGillivray. The bryozoan assemblage is comprised of separate, small−sized internal moulds dominated by distinct, boat−shaped zooecia belonging to Beania, scarce, unizooidal internodes tentatively included into a ditaxiporine catenicellid ?Vasignyella, and representative of the family Savignyellidae. A few branched segments composed of multiserial zooecia arranged back to back were tentatively incorporated into ?Malakosaria. Beania, marks the oldest fossil record, whereas representatives of Savignyelli− dae along with ditaxiporine catenicellid and ?Malakosaria are for the first time reported from Antarctica. The relationship between the taxonomic composition, colony growth−patterns rep− resented by membraniporiform/petraliform, catenicelliform and cellariform, along with asso− ciated biota and sedimentary structures of the La Meseta Formation implies nearshore environ− ment, with considerable wave action, and warm climatic conditions.


We present a brief overview of some recent observations of colliding galaxies and relevant numerical simulations. These are compared, and details of the locations and history of collision induced star formation are explored, with possible application to star formation at earlier epochs.


In this talk, Julia Davies draws upon a project looking at the role of Facebook in the lives of a group of fashion-conscious trainee hairdressers living in a city in the north of England. As ethnographic research, Dr. Davies shared in the young women's Facebook spaces and took part in their conversations. Facebook was the lens through which she viewed their lives and through which she traced interactions and events.


We consider secular perturbations of nearly Keplerian two-body motion under a perturbing potential that can be approximated to sufficient accuracy by expanding it to second order in the coordinates. After averaging over time to obtain the secular Hamiltonian, we use angular momentum and eccentricity vectors as elements. The method of variation of constants then leads to a set of equations of motion that are simple and regular, thus allowing efficient numerical integration. Some possible applications are briefly described.


This paper takes Grice's Cooperative Principle as an analyzing tool to study the conversations in Catch-22, a representative work of black humor. This thesis proves that the violation of Cooperative Principle can also create black humor. First present a general introduction to Heller and its work at first, which is followed by a brief introduction of cooperative principle. And then case analysis of the conversations creating black humor.


Calibrated automated thrombograms (CAT) with platelet‐poor (PPP) and platelet‐rich plasma (PRP) have provided useful insights on bleeding disorders. We used CAT to assess thrombin generation (TG) in Quebec platelet disorder (QPD)—a bleeding disorder caused by a PLAU duplication mutation that increases platelet (but not plasma) urokinase plasminogen activator (uPA), leading to intraplatelet (but not systemic) plasmin generation that degrades α‐granule proteins and causes platelet (but not plasma) factor V (FV) deficiency.


This paper takes as its starting point an ethnographical study of a spanking club for men created in France in 1988 and uses analytical tools created by Bourdieu to set out a historical sociology of deviant fantasies. The club emerged against a backdrop of sexual liberation and is designed to serve as a means of demanding freedom and allowing new criteria defining respectable sexuality to emerge. Spanking is frowned on as a puerile pleasure and somewhat unsavoury fantasy because of its association with child sexual abuse. Analysis of the discourse put forward by the club and its members reveals that this ambiguity is experienced as a constraint on how desire is experienced, but also provides ample possibility for eroticisation– in short, the discourse is double-faced, at once asserting and refuting any association with violence.


We show that the set of k-dimensional isoperimetric exponents of finitely presented groups is dense in the interval [1, \infty) for k > 1. Hence there is no higher-dimensional analogue of Gromov's gap (1,2) in the isoperimetric spectrum.


The study investigated socio-economic factors as attributes for examination malpractice among secondary school students in Cross River State-Nigeria. The survey research design was adopted for the study. The multistage sampling technique was used in selecting total of 1038 students for the study. The instrument employed for data collection was a four point scale developed, validated and administered by the researchers. Data collected was analyzed with the use of percentages and regression analysis. Among others it was found that, students' attribute examination malpractice more to societal factors, followed by school factor, and finally by personal factors. It was found that, there was a significant relationship between societal factors and attribution to examination malpractice. Base on these findings it was recommended among others that government should device a means of enforcing the law on examination malpractice and the process of employment into public offices should entail both written and oral examinations.


Developing an information literacy program in the 21st century requires more than simple planning - it requires a thoroughly designed strategy based on proven success. In this book, twenty information literacy experts, including Michael Eisenberg, Virginia Walter, and Lesley Farmer, explore various techniques and contribute perspectives on information literacy programs in educational environments from kindergarten through higher education, including public libraries. The result is an indispensable volume that provides an integrated, comprehensible approach for creating a successful, sustained program. The book is divided into chapters, each focusing on one of the 17 components that make up what authors Curzon and Lampert identify as the "information literacy wheel". Each section of the wheel - planning, teaching models, collaboration, marketing, assessment, and more - undergoes in-depth analysis by one of the information literacy professionals. Here is a key resource, packed with compelling analyses and real-world examples from the experts themselves, for developing an effective, multi-dimensional information literacy program in the 21st century.


This reference provides an overview of life on earth, bridging the gap between zoology and botany. The book demonstrates the amazing diversity of all living things in a manner that should be accessible.


Digitalization of the original maritime audio/visual archives plays a very important role in the modernized management, usage and communication of the archive information. This paper analyzes the necessity of the digitalization of the audio/visual archives and provides for reference to persons concerned the process to realize the digitalization and the issues to be considered.


A classification of interactive graphic systems, currently used to prepare plans and maps in surveying practice, is presented. The first generation of systems are graphics editors storing drawings that can be graphically changed and redrawn. A second generation of systems provides the same functionality as the first, but the user can add certain types of information to the graphical elements (e.g., tube diameter or material). The state-of-the-art third generation of systems internally stores models of reality, drawings and reports produced in varying formats are just operations to make these internal models visible to the user. Such systems can automatically maintain constraints on the model during changes. This classification seems to reflect a very general trend in computer applications toward systems that integrate an increasing amount of knowledge about reality.


Abstract The study investigated the effects of the addition of 0% (control group, CG), 0.25, 0.35, and 0.45% superfine smashed okra powder (SSOP) or carrageenan (CAR), and 0.25% SSOP – 0.35% CAR complex (OC) on the quality of chicken meatballs. Chicken meatballs fabricated with the SSOP-CAR complex showed better quality as compared to the other treatments. The lowest cooking loss was observed in the OC group, which corresponded to significantly decreased relaxation times of low-field nuclear magnetic resonance (LF-NMR) (T21 and T22) (P < 0.05). Compared to CG, The L* and a* values of chicken meatballs were significantly decreased due to the addition of SSOP (P < 0.05), and the additions of SSOP and CAR significantly increased the storage modulus (G′) and loss modulus of chicken meat batter upon heating (P < 0.05). Besides, the OC and 0.45% CAR groups showed the highest texture profile values for hardness and chewiness (P < 0.05). The sensory evaluation revealed that the chicken meatballs emulsified with the OC had the best overall acceptability. The results indicated that OC could be a great feasible and potential application in the meat industry, especially in the development of functional emulsified meat products.


A number of concerns have been raised about the suitability of computer-mediated communication (CMC) for supporting socialization in educational settings. To investigate this issue, we developed a survey instrument that measures perceptions of CMC relating to socialization and administered the instrument in two different educational contexts: one that used CMC for general course-related and personal communication and one that used CMC to support team projects. CMC was perceived to be significantly better for initiating social relationships and for social influence in the context of general communication than in project teamwork. No differences were seen between contexts on the measure of social intimacy. These findings have interesting implications concerning expectations for CMC in educational settings.


Objective: To observe the efficacy of MEBO in treating wounds post excision of hemorrhoid and fistula. Method: 153 cases of this disease were treated MEBO gauze. The dressing was changed every day. At the same time, antibiotic drug was administered as well as comprehensive treatment. Result: Pain was quickly relieved. Wound healing was promoted. Scar formation was reduced. No complications such as anal stricture, anal distortion, mucosal extroversion and exudation happened. The function of the anus was good. Conclusion: MEBO is efficacious in treating wounds after hemorrhoid and fistula excision. It can promote skin tissue regeneration and repair and lessen pains.


This chapter explores how the Hebrew aljamiado copy of the Danza, Iberia's version of the European Dance of Death, fits into MS Parm. 2666 and reflects its compiler/s' and copyist/s' contemplation on the role of wealth, status, and wisdom in this world. The figure of Death in this Iberian Dance of Death has some unique characteristics that suggest it has its origins in, and would have resonated with readers from the Semitic traditions of the Peninsula. In the Iberian Danza all are not equal in Death, and the text underscores that their status in death is ambiguous at best, known only to God and recorded in the "libro de la vidas". The chapter discusses the version of the Danza in MS Parm. 2666 and how and why it was recorded and used, how it was given meaning, by the converso, crypto-Jew or Jew that recorded it.Keywords: aljamiado; crypto-Jews; Dance of Death; Danza; Iberia; MS Parm. 2666; Semitic traditions


Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortalities world-wide. Targeted therapy has been a growing topic of investigation to improve therapeutic efficacy for NSCLC. A few targeted therapies that exploit aberrant protein expression profiles have been approved for NSCLC. However, marginal improvement in efficacy observed with these therapeutic approaches highlights the need for discovery of additional therapeutic targets. Tax interacting protein 1 (TIP1) is a molecular target that is overexpressed on the surface of various cancers and correlates with poor overall patient survival. The functional domain of TIP1 (PDZ domain) caps the C-terminus of many cellular proteins that regulate cell signaling, cancer development, and progression. We found that antibodies against the PDZ domain of TIP1 induced cytotoxicity of lung cancer cells but not normal cells. A quantitative mass spectrometry-based approach identified a ten-fold increase in Midkine protein expression on blockade of TIP1. Midkine is a heparin-binding growth factor that is involved in cancer progression, therapy resistance, and immune suppression. This study tested the hypothesis that Midkine is upregulated by the anti-PDZ/TIP1 antibody via the β-catenin/Wnt signaling pathway, which subsequently modulates downstream signaling mechanisms. In co-immunoprecipitation studies we found a direct interaction of TIP1 with β-catenin on the cell surface. Anti-TIP1 antibody treatment led to nuclear translocation of β-catenin in NSCLC cells. We used a luciferase based TOPFlash/FOPFlash reporter assay to study the transcriptional activity of the canonical β-catenin/Wnt pathway following TIP1 blockade. Reporter assays showed a three to four-fold increase (p<0.0001) in the transcriptional activity of β-catenin following TIP1 blockade in NSCLC cells. Genetic silencing of β-catenin inhibited Midkine mRNA transcription (p<0.005), protein induction and its extracellular release (p<0.0001) following anti-TIP1 antibody treatment. In conclusion, the mechanism of Midkine release following TIP1 blockade involves the β-catenin/Wnt signaling pathway. Ongoing studies are evaluating the dual-targeting of TIP1 and Midkine for enhanced efficacy of NSCLC treatment.
 Citation Format: Minakshi Saikia, Abhay K. Singh, Nathan Cheung, Dennis E. Hallahan, Vaishali Kapoor. Blocking the functional domain of TIP1 upregulates midkine via the β-catenin/Wnt signaling pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2566.


The characteristic of the drift error of inertial platform system is a high-order nonlinear dynamic system.Using the neural networks' abilities of universal approximation of differentiable trajectory and capturing system dynamic information,this paper presents the drift error identifying project of inertial platform based on neural network.The drift error model of inertial platform is established,and training the NN model by BP algorithm,the system achieves satisfied modeling identification results.


This dissertation's research aims at studying the viability of using both low cost consumer Commodity Off The Self (COTS)PCs and libn~software in implementing a distributed real-time system modeled on a real-world engineering problem. Debugging and developing a modular satellite system is both time consuming and complex, to this end the SUNSATteam has envisioned the Interactive Test System that would be a dual mode simulator/monitoring system. It is this system that requires a real-time back-end and is used as a real world problem model to implement. The implementation was accomplished by researching the available parallel processing software and real-time extensions to GNU/Linux and choosing the appropriate solutions based on the needs of the model. A monitoring system was also implemented, for system verification, using freely available system monitoring utilities. The model was successfully implemented and verified with a global synchronization of < 10ms. It was shown that GNU/Linux and libn~ software is both mature enough and appropriate in solving a real world distributed real-time problem. ii Stellenbosch University http://scholar.sun.ac.za


A new characteristic mixed finite element method is developed for solving saltwater intrusion problem. In this algorithm, the splitting mixed finite element (SMFE) method is applied for solving the parabolic-type water head equation, and the mass-conservative characteristic (MCC) finite element method is applied for solving the convection-diffusion type concentration equation. The application of the splitting mixed element method results in a symmetric positive definite coefficient matrix of the mixed element system and separating the flux equation from the water head equation. While the mass-conservative characteristic finite element method does well in handling convection-dominant diffusion problem and keeps mass balance. The convergence of this method is considered and the optimal L2-norm error estimate is also derived. c ©2017 All rights reserved.


This paper builds on the work of Yates & Mosleh [1] in developing a Bayesian reliability demonstration methodology for Australian defence that is simple to employ yet effective in minimizing test resources, maximizing test accuracy and ultimately minimizing financial and operational risk. The additional work is required primarily to resolve issues with respect to understanding the influence of the various parameters and test planning. The paper presents a sensitivity analysis on the parameters of BRDT's, which establishes that the parameters of the Prior are the most significant source of error in the analysis. It also shows that the results are not particularly sensitive to variations in weight. A number of test planning methodologies for both exponential MTBF and P5 problems are then considered, with the conclusion that the sequential BRDT approach outlined in [2] is the most appropriate to meet the requirements. On the basis of these findings, the paper discusses a potential BRDT process for Australian Defence based on sequential methods and the work of [I]. This will require specification of maximum weights for each evidence class and acceptable risks in the contractual documents, as well as the required reliability characteristics. It will also necessitate formal pre-posterior analysis to ensure the Prior is appropriate and may also require the contractor to seek out additional evidence to satisfy the risk goals.


The Hipparcos reference frame is defined by the positions and proper motions of ~10 5 stars given in the Hipparcos Catalogue (ESA, 1997). It is the optical counterpart of the International Celestial Reference Frame defined by the radio positions of extragalactic sources. The linking of the Hipparcos frame to the extragalactic frame is described by Kovalevsky et al. (1997) and Kovalevsky (1997). In the present review we consider only the intrinsic properties of the Hipparcos reference frame. A complete description of the contents of the Hipparcos Catalogue is contained in Volume 1 of ESA (1997). Recent overviews have been given by Perryman et al. (1997) and Perryman (1997). The principal astrometric data provided are the barycentric coordinates (α, δ) of the stars, the trigonometric parallaxes (π) and the proper motion components (μ α* = μ α cos δ, μ δ ). These parameters are given in the main catalogue for 117955 entries along with estimated standard errors and correlation coefficients, all data being referred to the common reference epoch T o = J1991.25 on the Terrestrial Time (TT) scale. Typical ranges of the astrometric standard errors and some other characteristics of the catalogue are shown in Table 1.


ABSTRACT In this study, we explore the concerns of elementary education (ELED) teaching candidates regarding teaching science in the outdoors and how their apprehensions might have been shaped by their recollected Environmental Socialization (ES) experiences during childhood. Qualitative and quantitative survey data were collected and analyzed using convergent mixed methods design. Data included responses to an open-ended question about their concerns teaching outdoors, responses to a Likert-type question about fear teaching outdoors, and responses to the frequency of recollected ES experiences. The open-ended question was coded first for themes and five themes emerged. Quantitative data from recollected ES experiences were then used to classify ELED candidates as either Low ES or High ES and then responses to the open-ended item were reanalyzed to examine differences by group. Additionally, the response to a Likert-type item about fear of teaching in the outdoors was statistically examined for group differences. Overall, ELED candidates recalled significantly higher participation in DE-D (Stage 1) ES experiences and much less participation in EFS (Stage 2) ES experiences. Statistically significant differences were found between Low ES and High ES candidates, in addition to stark contrasts in their reporting of concerns. We posit that the lack of EFS experiences has the potential to impact how these future elementary teachers will choose to engage in outdoor teaching opportunities.


No. 151 — May 2014 the democratic potentialities in online communities of producers/produsers; and several disparate chapters on 'producing the (un)civic web,' covering topics ranging from the 'Occupy Wall Street' movement to the corporate monetisation of Facebook fan pages. Drawing on presentations from the 'Organized Producers of Net Cultures' symposium in May 2011, the collection aims to engage critically with familiar key concepts and issues. One of the most interesting preoccupations underpinning the book is that it seeks to distance itself from, and to a degree question, prominently used terminology such as 'participatory culture' and Axel Bruns' 'produsage', which volume editor Tobias Olsson contends in his introductory essay has 'mythologized, rather than analyzed' (p. 13) the immense social, cultural and economic changes brought about by the internet, thereby signalling the need to 'resuscitate the very notion of producers within contemporary media research' (p. 18). Christian Fuchs' essay makes a compelling case in relation to this in his critique of the 'positivistic mainstream' (p. 43) of internet studies, stressing the need to acknowledge the 'exploitation of user labour' exhibited in corporate uses of social media (p. 27). Further underlining the ongoing relevance of the concept of 'producers', Dino Viscovi and Malin Gustafsson expose (in addition to the free content garnered from news site users) the overwhelmingly negative impressions of public comments and commenters on the part of journalists interviewed in Sweden. The collection expands to some degree on the considerable scholarship in the area in a theoretical sense; however, the most important contributions the authors make to ongoing debates is by considering these in relation to less frequently discussed settings. Within its European context, the discussions of Swedish-born case studies such as the physical exercise networking site jogg.se and the digital horse training/racing site stallet.se, as well as the government-sponsored community 'Malmö in Second Life', are fascinating. Ulrika Sjöberg and Ingegerd Rydin's examination of the digital endeavours of Swedish public service television reveal a number of parallels with equivalent multiplatforming practices in Australia. While I felt that the surveillance implications of many of the platforms discussed deserved more attention at times, the collection as a whole offers valuable insights into how the concept of 'participation' should be understood, given the inherent complexities of contemporary media environments. All essays are accessible and well written (despite the book's awkward subtitle) and, although the volume is not explicitly targeted towards the purpose of teaching curricula, would serve as a useful resource for an undergraduate unit of study as a recommended text. — Adam Brown, Communication and Creative Arts, Deakin University


It comes to be able to perform screening test which added functional information simply by using the modified flat panel detector(FPD).The purpose of this research is analyzing the dynamic state of heart wall from sequential chest images at the short period by the modified FPD. The heart beat process, peak expiratory and respiratory pause, was taken in three healthy volunteer sa nd ap atient of ischemic heart disease. Horizontal movement of heart wall in the left atrium, the left ventricle, and the cardiac apex part were analyzed for the sequential 30 images(6 frame/sec x 5sec).The result was approximated to the sign curve and amplitude(move distance of heart wall)and frequency(heart rate)were analyzed. Compared with the normal case, abnormal case's pulsation in the left ventricle and the cardiac apex part were small, and its cycle was also irregular than the analysis result. It is suggested that this method is useful as heart dynamic examination to diagnosis of angina, myocardial infarction, etc. which cause abnormalities of heart wall movement.


The CP-52 and CP-54 wells are located on the Tambun structure of Bekasi Regency of West Java Province with the target formation being Baturaja. The pressure build up analysis is carried out for monitoring activities to obtain reservoir and boundary, innitial pressure (Pi), permeability (k), skin (s), ΔP skin, average pressure (Pavg), and flow efficiency information. Tests performed on both wells are pressure build up test (PBU) and to analyze the method of Horner approach pseudo pressure and P2 either manually or with the help of software v.ex.2 v2.02 as validation.


(Volume 3).- VII. Discrete Physics Commentary.- [179] Random Lattice Field Theory: General Formulation.- [180] Gauge Theory on a Random Lattice.- [181] Weights of Links and Plaquettes in a Random Lattice.- [182] Can Time Be a Discrete Dynamical Variable?.- [183] Discrete Quantum Mechanics.- [185] Discrete Mechanics.- [188] Derivation of Regge's Action from Einstein's Theory of General Relativity.- [189] Lattice Gravity Near the Continuum Limit.- [195] Physics in Terms of Difference Equations.- VIII. Strong Interaction Models Commentary.- [72] Implications of Approximate SU3 Symmetry and Mass Formulas for the Mesons.- [143] Scaling Properties and the Bound-state Nature of the Physical Nucleon.- [144] A Simple Bound-state Model of the Physical Nucleon.- [145] Multiplicity Distribution in the Multiperipheral Model and a Onedimensional Gas.- [152] Abnormal Nuclear States and Vacuum Excitations.- [155] A Possible New Form of Matter at High Density.- [156] Interactions of a Dense Fermion Medium with a Scalar Meson Field.- [156a] Corrections to "Interactions of a Dense Fermion Medium with a Scalar Meson Field.- [170] Abnormal Nuclear States.- [176] QCD and the Bag Model of Hadrons.- IX. Historical Papers.- [136] History of Weak Interactions.- [186] Broken Parity.- X. Gravity (Continuum Theory).- [192] Are Black Holes Black Bodies?.- Permissions.


A quantized probability distribution is defined for a sequence of digital data produced by a Bernoulli source. From it, both a grouped distribution and a histogram are obtained. Their entropies are considered, and relationships between them are derived. Some applications are described, and a commentary about microscopic uncertainty versus macroscopic information is presented, with a related entropic modulation factor.


We propose a simple yet efficient mechanism for passive error correction in topological quantum memories. Our scheme relies on driven-dissipative ancilla systems which couple to local excitations (anyons) and make them "sink" in energy, with no required interaction among ancillae or anyons. Through this process, anyons created by some thermal environment end up trapped in potential "trenches" that they themselves generate, which can be interpreted as a "memory foam" for anyons. This self-trapping mechanism provides an energy barrier for anyon propagation and removes entropy from the memory by favoring anyon recombination over anyon separation (responsible for memory errors). We demonstrate that our scheme leads to an exponential increase of the memory-coherence time with system size L, up to an upper bound L_(max), which can increase exponentially with Δ/T, where T is the temperature and Δ is some energy scale defined by potential trenches. This results in a double exponential increase of the memory time with Δ/T, which greatly improves over the Arrhenius (single-exponential) scaling found in typical quantum memories.


In this paper,we discuss and prove te existence of VB direction of the meromorphic functions which satisfy the folling contion:(lim)——r→∞lnT(r,f)lnlnr=k(2k∞)so that in another way,without considering the fulling-up disc,we prov the existence of Borel direction on the meromorphic functions of zero order again.


There is often a trade-off between building deep learning systems that are expressive enough to capture the nuances of the reality, and having the right inductive biases for efficient learning. We introduce Residual Pathway Priors (RPPs) as a method for converting hard architectural constraints into soft priors, guiding models towards structured solutions, while retaining the ability to capture additional complexity. Using RPPs, we construct neural network priors with inductive biases for equivariances, but without limiting flexibility. We show that RPPs are resilient to approximate or misspecified symmetries, and are as effective as fully constrained models even when symmetries are exact. We showcase the broad applicability of RPPs with dynamical systems, tabular data, and reinforcement learning. In Mujoco locomotion tasks, where contact forces and directional rewards violate strict equivariance assumptions, the RPP outperforms baseline model-free RL agents, and also improves the learned transition models for model-based RL.


As an alternative to baseline technology a low-temperature syngas separation process has been proposed for pre-combustion CO2 capture from coal-derived syngas for an IGCC plant. Through systematic process synthesis – sequencing of separators and location of compressors and expanders, followed by Pinch Analysis and energy targeting – a process design has been proposed and the net power consumption has been estimated. From a targeted power consumption of 21.9 MW the figure for the proposed design is increased to 22.9 MW mainly due to increased load for auxiliary refrigeration at low temperature. The power consumption of the proposed design represents further improvement from earlier designs that have already been shown to have higher energy efficiency than baseline technology.


Road safety is a serious problem worldwide, and especially so in developing nations such as Tanzania. The government of Tanzania has made a strong commitment to deal with road safety problems by developing and implementing a comprehensive road safety program. This paper discusses the problems that have caused the current road safety situation in Tanzania, focusing on the institutional set up of road safety activities, traffic legislation, law enforcement, training and education, vehicle safety/inspection, road traffic management, and post-collision assistance. Recommendations are provided as to what still remains to be done to reverse the current situation to help mitigate the number of accidents and fatalities caused by traffic accidents.


The amount of dirt or impurities in pulp and paper is a critical quality characteristic. Manufacturers evaluate dirt content by sampling a small portion of their production. In such cases, the estimate of the error associated with the measurement itself. Whether the analytical procedure is manual or automatic, the randomness inherent in the sampling process is the biggest contributor to variability. This paper presents a theoretical model that explains the observed randomness and provides an equation for estimating the error of the measurement. It is proved that if m is the number of impurities detected in the sample, then l/m 12 is a lower bound for the relative error of the estimate and, in many cases, a good approximation of the expected error.


In this paper, we investigate the suppliers' allocation decisions between different product forms and markets using supply equations derived from a translog revenue function. This is of interest based on the hypothesis that fish processors and importers respond to changes in relative prices, diverting more fish into products or to markets where the price has risen. This can also at least partially explain the strong degree of correlation between prices of different product forms and markets that is observed in many seafood markets. An empirical analysis is carried out for cod for three main producers, Canada, Iceland, and Norway. The supply of cod exhibits substantial variation, and it is processed into a number of product forms. How the landings are allocated between product forms is then of substantial interest in itself, but also with respect to the influence of new species in the whitefish market, like pollock.


The new perovskite compound La0.5Ba0.5FeO3−δ was prepared by the sol–gel method. The Rietveld refinement, from the X-ray diffraction pattern, proved that the sample presents single phase type cubic structure at room temperature. In addition, electrical properties were performed using complex impedance spectroscopy (CIS) technique as a function of frequency (100 Hz to 7 MHz) at various temperatures (278–573 K). As a matter of fact, impedance analysis was performed using the equivalent circuit model and it indicated the presence of a single semicircle arc. Furthermore, the obtained results of the AC conductivity have been discussed in terms of the non-overlapping small polaron tunneling (NSPT) model. Finally, it is worth mentioning that the conductivity of our investigated perovskite oxide was found to be σ573 = 1.23 × 10−2 Ω−1 cm−1. These results confer to this material a potential application as a cathode material.


Tuberculous kyphosis is an unstable lesion that tends to progress and lead to many problems.Various corrective osteotomies  for kyphosis have been described for various conditions, but not for tuberculosis. This articles proposed shortening procedure to correct tuberculous kyphosis. The preexperimental study  was conducted in 49 patients with tuberculous kyphosis treated surgically at Cipto Mangunkusumo and Fatmawati hospital since June 1996 till June 2001. All patients were evaluated radiographically in the preoperative period, postoperative period, and at the latest follow-up (6-36 months). Neurological deficit risk of operation was also evaluated by Frankel grading. The kyphosis were classified  into three group, group A (kyphosis 30° - 59°) group B (60° - 89°) and group C (90° - 120°). The average postoperative  kyphosis correction was 30.82° (67.5%); in group A 28° (75.49%), in group B 42.3° (62.43%), and in group C 27° (23.36%). Anova test gave significant difference in persentage of postoperative correction. Paired t-test also gave significance postoperative correction in all groups. Neurological complication was found in 6 patients  (12.2%); 4 (11,8%) in group A dan 2 (40%) in group C, and no statistical difference between the two groups concerning this complication (p=0.1023). We concluded that shortening procedure for tuberculous kyphosis gave significant correction. In TB-kyphosis > 90° shortening procedure still gave significant correction although a potential risk of serious neurologic complication. (Med J Indones 2004; 13: 47-52) Keywords: Shortening procedure, tuberculous kyphosis


Natural events are believed to have contributed to an increased global temperature. This is caused primarily by increase in greenhouse gases effect, such as carbon dioxide (CO2). This study evaluated assessment of carbon foot prints in 3 out of the 5 Departments in the Faculty of Agriculture and Forestry, Cross River University of Technology, Obubra Campus. Purposive sampling methods was adopted to involve students studying Animal Science, Agronomy and Forestry base disciplines within the Faculty. Carbon foot print online calculator developed by (WWF, 2016) was used for the assessment. The calculator had well-structured questions to monitor carbon foot print generated by each student activities through food, home, travel and stuff. The results were analyzed using Analysis of Variance (ANOVA). Tables were used to compare with the global average planet of 3.06 tones for human existence on the earth surface. The Department of Animal Science recorded the highest carbon foot print of 614.18 tonnes requiring 6.53 tonnes planets to cohabit. The lowest carbon foot print of 469.0 tonnes was obtained in the Department of Forestry requiring 6.52 tonnes planets to exists. 500 level students generated the highest carbon foot print 356.48 tonnes requiring 7.22 tonnes of global average planets. While, the least foot print was observed in 200 level students 307.54 tonnes. The male and female students produced the same average carbon foot print of 625.3 tonnes. Investigation revealed high carbon foot print in food consumption, travel and home required more planets to sustain our lives in the


The deep change of China in the 20th century can't be reached by one political party or one class. It is the result of the join force formed by several factors and several forces. Thus, without Chinese u- nited front, there can't be Chinese historical progress in the 20th century. The united front led by the Party during the 80 years developing experience, has made historical contribution for Chinese nation's indepen- dence, unity, flourish, democracy and Chinese people's greater funtion on the world stage.


This research is an analysis about how philosophy, neuroscience and pedagogy, have as common theme the study of brain, mind, and education, and answer the current need to develop educational practice with neuroscientific bases, it is classified in the field of educational neuroscience. When these disciplines work together, generate a transdisciplinary knowledge, which enables the education community think philosophically in the ability to perceive the world through sensory systems, and how they co-evolve with learning systems and human action, thus achieving unite scientific knowledge and educational practice.
The philosophy of sounds and auditory perception is an emerging area in the field of philosophy of perception, which goes beyond the visual understanding of the nature, objects, content, and varieties of perception. On this basis the contribution of auditory perceptual style, that is, establishing the construction of sound sense from the specialized use of hearing according to structure a linguistic discourse in its real-emotional, clear sound context own you will see in the process of teaching and learning.
Therefore, starting from the cerebral substrate underlying auditory perception and establishing the foundations of knowledge, educational implications are proposed based on an auditory aesthetic that enhances the analytical reading and music appreciation.


A new integrated layout optimization method is proposed here for the design of multi‐component systems. By introducing movable components into the design domain, the components layout and the supporting structural topology are optimized simultaneously. The developed design procedure mainly consists of three parts: (i) Introduction of non‐overlap constraints between components. The finite circle method (FCM) is used to avoid the components overlaps and also overlaps between components and the design domain boundaries. (ii) Layout optimization of the components and supporting structure. Locations and orientations of the components are assumed as geometrical design variables for the optimal placement while topology design variables of the supporting structure are defined by the density points. Meanwhile, embedded meshing techniques are developed to take into account the finite element mesh change caused by the component movements. (iii) Consistent material interpolation scheme between element stiffness and inertial load. The commonly used solid isotropic material with penalization model is improved to avoid the singularity of localized deformation in the presence of design dependent loading when the element stiffness and the involved inertial load are weakened by the element material removal.


Two thousand and thirty-nine trees on 213 plots are being monitored yearly for
root disease infection and mortality. Three compartments on the Fernan Ranger
District of the Idaho Panhandle National Forests are the site of the project.
Relationships between factors such as species, aspect, slope, elevation,
habitat type, stand appearance on aerial photography, plot root disease
severity ratings, and measured volume losses due to root disease mortality are
being evaluated. Effective means of judging past and future losses in root
disease-affected stands are sought.


In 1967, Coates discovered the electron channelling contrast of backscattered electrons (BSEs) in scanning electron microscopy, and by this the possibility to investigate arrangements of lattice defects in deformed microstructures of materials. Since that time, a straightforward development of the scanning electron microscopes as well as of the electron channelling contrast technique took place. Nowadays, the performance of scanning electron microscopes is high enough that the resolution of electron channelling contrast imaging (ECCI) micrographs is comparable with conventional bright field transmission electron microscopy (TEM) micrographs. In the first part of the present paper, a historical review on the development of the ECCI technique starting from its discovery more than 45 years ago up to the combination with other advanced methods of scanning electron microscopy like electron backscatter diffraction or high-resolution selected area channelling patterning in the last few years is given. Major important investigations using this technique for the visualization of individual lattice defects like stacking faults (SFs) and dislocations or dislocation arrangements are chronologically summarized. The second part demonstrates that nowadays, ECCI micrographs taken in high-resolution scanning electron microscopes can be called high-resolution ECCI (HR-ECCI). It is shown that the resolution of individual SFs and dislocations in the HR-ECCI micrographs is comparable to that of conventional TEM (about 15 nm defect image width). Furthermore, the paper is demonstrating that HR-ECCI micrographs can be obtained for various types of materials after different mechanical loadings and different grain sizes ranging from large grain size of 500 μm (cast steel) down to less than 2 μm (γ-TiAl).


Heterogeneous performance of the firms is explained by several different theories. Following the notion of resource-based view, this conceptual study attempts to bring in the human capital theory to explain firm performance. Empirical researches studying human capital management are numerous in western countries. However, not much can be said about the deployment of Malaysian human capital especially in R&D firms since very little empirical studies have been done to understand this sector. Therefore, in general this paper intends to argue the role of human capital in influencing performance. In specific, it attempts to examine the relationship between human capital and organizational performance and whether environmental dynamism, uncertainty and munificence have moderating effects on this relationship.


Technology as a key dimension of service quality has generally been overlooked. When embedded in organisation culture, technology creates a competitive advantage sustainable over time because it is not easily imitated. The value of developing operational definitions of service quality dimensions is explored. Technology is investigated not only as input‐processing‐output but as the application of knowledge to work. Two components of technology are: service logic (know‐why) and service technique (know‐how). Service logic is offered as the means for expressing causal relationships in a way that establishes rational connections between seemingly unrelated operating events. Service technique is viewed as a way of doing things designed to optimise customer satisfaction while maximising employee satisfaction. The service map is presented as a managerial tool for discovery of the service logic that gives rise to service technique.


This study reports on ESP (English for specific purposes) instruction of technology industries for students in the department of applied foreign languages of a technical university. The instruction was conducted by a teacher with academic subject background, work experience and English proficiency that succeeded in leading students to an effective meaningful learning. The results suggested that students have benefited from the instruction and had a better performance on the final grade. Those with higher achievement showed better self-discipline, participation and motivation in attending the class so that they were more competent to learn such a technological and professional ESP course.


Measure-Correlate-Predict (MCP) is not only a primary technical method to evaluate the development level of wind resource of a wind farm in plan, but it can also determine the annual energy production. The result of MCP can be influenced by the long term wind reference data, which means that if the long term wind reference data is low in credibility, the result of MCP is also unreliable; and then the wind resource assessment of the wind farm in plan can be false. However, in engineering practice, the long term wind reference data from meteorological stations can be affected by some objective factors, such as the new buildings around the wind masts; small trees around the wind masts can grow up to 20m or even higher, which would also affect the wind data. The NCEP/NCAR reanalysis dataset, which are produced by National Centers for Environmental Prediction (NCEP) and National Center for Atmospheric Research (NCAR), is widely used as an alternative long term wind reference data. The dataset is available from January 1 in 1948 to the present and data samples are recorded every 6 hours. Surface wind data and 10 m wind data are available and are saved on a grid at 2.5 degree resolution at different air pressure levels ranging from 10 hPa to 1000 hPa. This paper studies the application of the NCEP/NCAR reanalysis dataset in the wind resource assessment, because of the low resolution of the NCEP/NCAR reanalysis dataset and the general MCP methods, such as the regression method, the Weibull scale method and the matrix method, are not sufficient any more; therefore, a new MCP method, named as wind index, is presented. For evaluate the feasibility of the dataset and the new MCP method, a case study is carried out. The calculated energy production of the studied wind farm, which is based on the long term wind reference data from meteorological stations and NCEP/NCAR reanalysis dataset are compared. The result shows that the calculated energy production is very close to real energy production, which means that different long term reference wind data and different MCP methods show almost same development level of wind resource. Therefore, it can be concluded that the combination of the NCEP/NCAR reanalysis dataset with wind index MCP method is a very reliable MCP calculation principle and can have a good practical value.


Recently it has been revealed that the number of ssDNA-phages in the environment is much greater than previously expected. Improved viral counting methods have increased ssDNA-phage detections, resulting in the expansion of the only known ssDNA-phage family Microviridae. However, completely new ssDNAphage families have not been found. In this study a new ssDNA-bacteriophage V155, previously isolated from the lake Jyvasjarvi, was characterized. The aim was to study the features of the phage and also find out if V155 belongs to the Microviridae-family. Numerous metagenomic analyses have revealed that ssDNAphages are common in fresh waters. However, this is the first time that lake derived ssDNA-phage is cultivated in laboratory in order to characterize its morphology, host range and life cycle. The genome of the bacteriophage was confirmed to be ssDNA by various nuclease treatments, and its protein profile and the existence of lipid structures were analyzed in SDS-PAGE. The morphology of the phage and its hosts as well as the phage-host-interactions were researched using electron microscopy. In addition, the host range and the life cycle of the phage were studied using infection experiments and plaque analysis. It was revealed that the capsid of V155 is icosahedral in the same manner as in the other Microviridae. However, the capsid size greatly exceeds that of the known ssDNA-phages. According to the chloroform tests and lipid staining of the electrophoresis gel, the virion seems to contain lipids, yet further research is needed in order to confirm this. If membrane structures were found, it would make V155 unique within the known ssDNA-phages. In the host range experiments it was discovered that the phage is able to infect three different Flavobacterium strains. There are no other reports of Flavobacterium as a host species for Microviridae. Furthermore, the plaque morphology and the difficulties growing the phage in liquid culture indicate, that when needed, V155 is able to shift from lytic to lysogenic life cycle. This is relatively rare within the known ssDNA-phages. According to these results V155 has clear similarities to the Microviridae-family. Nevertheless, the differences revealed during the research make it plausible that this bacteriophage belongs to a new Microviridae-subfamily, or possibly even to a completely new viral family. More structure and sequence research is still needed in order to characterize the phylogeny of V155 comprehensively.


The title compound, C14H16FN5O3, was synthesized and the structure was investigated by X-ray crystallography. It crystallizes in the triclinic system, space group P1 with a = 7.9062(9)A, b = 10.4189(12)A, c = 10.5347(12)A, α = 62.983(2)°, β = 70.570(2)°, γ = 76.828(3)°, V = 726.01(14)A3, Z = 2, R = 0.0494. The crystal structure is stabilized by intermolecular N-H…O hydrogen bonds and a π-π stacking interaction between the quinolone rings.


FIELD: information technologies. SUBSTANCE: system to store and search for medical data in a medical institution, comprising software implemented in this system and user-oriented, which functions to display a start page to a user that has just entered the system, and the start page, in particular, belongs to the area of the user's responsibility, with the displayed information, containing a contextual list of options related to the user's working process, which assists in quick access and navigation of a user along one or several data areas, in particular, related to duties and functions of the user. EFFECT: quick access and navigation of a user in one or several data areas of a medical data management system, data areas of which, in particular, relate to functions and duties of a user. 9 cl, 23 dwg


Objectives: to identify the main health problems of the prison population, describe the sociodemographic and health of convicts profile; point the main complaints and more frequent pathologies. Method: exploratory, descriptive, quantitative and qualitative, held in a maximum security prison. The study sample was composed of 63 convicts, which answer a semi-structured form. For the analysis, there was the simple descriptive statistics and discourse analysis of the collective subject. Results: the prison population is young, with low educational level and family income, present as the main pathologies skin disorders, respiratory disorders, gastrointestinal, cardiovascular, and infectious diseases. Final considerations are numerous health problems presented by the detainees, as well as their complaints ranging from lack of medical care and other health professionals, to the unsanitary conditions in which live, and picture of state failure and the competent bodies.


This invention relates to the complex health protection nutriment made with the mixture of fungoid preparation, the extracting matter of medical edibles (the extracting matter of Chinese medicine) and the trace element of active calcium, selenium and genmanium. Its feature is that the fermented technology of bioengineering is used to make the fungoid preparation, the trace element of active calcium, selenium and germanium can add in biofermented process of fungoid strain and the effective components are extracted from the Chinese medicine or medical edibles by secondary back flow method with alcohol. This method has the adventages of low cost, high extracting rate, short production period and high quality of product.


The article is devoted to the problem of credit rating under the unstable economic situation in the country, the negative impact of sanctions, reduced solvency of enterprises and the public which is becoming increasingly important for domestic commercial banks. In a crisis, both individuals and legal entities experience difficulties in fulfilling their obligations due to a lack of funds. Therefore, they are forced to apply for credit resources more often than in a stable economy. In this regard, banks should insure themselves against credit risks even at the initial stage of lending, which is possible only if the credit organization has an effective credit rating system, which allows obtaining the highest quality information about the borrower, his capabilities and readiness to return lent funds.
The main hypothesis of the study is that at present there is no uniform methodology that allows evaluating credit rating in full. In this regard, banks are developing their own methods, generally similar to each other.


The emphasis has been placed on the fact that the state has the main responsibility for the formation of state policy in the field of education and the development of effective mechanism for its implementation. The author has emphasized that without the development of effective mechanism for the implementation of the educational function of the state it will be impossible to ensure the proper functioning of all spheres of public life: political, economic, cultural, environmental, informational, law enforcement, etc. In this regard, it has been focused on the importance of clarifying the content of the educational function of the state, developing effective mechanisms for its implementation.
The education has been offered to be understood as a complex process regulated by the norms of national legislation, to ensure its quality we create relevant entities, entitled to provide educational services, which allows recipients of such services to realize personal potential based on their abilities, interests, needs, motivation, capabilities and experience. It has been established that the understanding of education as the result or process is the feature of the expediency of legal interpretation of this term, since procedural issues related to the organization of the educational process, education, establishment and operation of educational institutions, education management, etc. are regulated by law, primarily by administrative law.
As a result of revealing the essence of the categories "function of the state" and "education" the author has formulated own definition of the concept of "educational function of the state" as the direction conditioned by the social purpose of the state, during which the state (in the form of state and non-state subjects of educational activity) creates proper conditions to meet the needs of citizens for their intellectual, spiritual, physical and cultural development, to provide them with equal access to educational services, which, as a consequence, may lead to the achievement of the planned learning outcomes. The conclusion about the two-component purpose of the educational function of the state has been made.
It has been substantiated that the implementation of the educational function of the state is mainly carried out with the help of administrative and legal tools. The characteristic features inherent in the educational function of the state as an object of administrative and legal regulation have been outlined.
The author has distinguished the main prerequisites for ensuring the proper implementation of the educational function of the state: a) the existence of a coherent system of regulatory acts, the provisions of which determine the priority areas of the state educational policy and take into account European educational standards, while developing an effective mechanism for implementing regulations; b) clearly defined range of subjects of management in the field of education with the consolidation of their administrative and legal status at the legislative level; c) the system of financial and logistical support of procedures for the provision and consumption of educational services must be scientifically sound and take into account modern innovative tendencies in the education sphere; d) development of an effective mechanism for motivating the employees in the field of education to use innovative technologies.


The present invention relates to a class of piperazine substituted 1,3-disubstitued urea compounds and piperazine substituted amide compounds, or pharmaceutically acceptable salts of the piperazine substituted 1,3-disubstitued urea compounds and the piperazine substituted amide compounds, a preparation method of the piperazine substituted 1,3-disubstitued urea compounds and the piperazine substituted amide compounds, a drug composition containing the piperazine substituted 1,3-disubstitued urea compounds and the piperazine substituted amide compounds, and a use of the piperazine substituted 1,3-disubstitued urea compounds and the piperazine substituted amide compounds in preparation of a soluble epoxide hydrolase inhibitor, wherein the piperazine substituted 1,3-disubstitued urea compounds, the piperazine substituted amide compounds, or the pharmaceutically acceptable salts of the piperazine substituted 1,3-disubstitued urea compounds and the piperazine substituted amide compounds are presented by the following general formula (I). The compounds of the present invention provide the same activity or the higher activity compared to a compound in the prior art, and have characteristics of water solubility suitable for preparation and administration, and excellent pharmacokinetic property.


A RESEARCH WORK SUBMITTED TO THE POSTGRADUATE
SCHOOL, AHMADU BELLO UNIVERSITY ZARIA, IN
PARTIAL FULFILLMENT FOR THE AWARD OF MASTER OF
SCIENCE DEGREE (M.SC. PHYSICS) PHYSICS
DEPARTMENT, AHMADU BELLO UNIVERSITY ZARIA
October, 2010


Background: The aging population and increasing prevalence of diabetes are placing significant strain on healthcare systems globally, including in Poland. In recent years, notable progress has been made in establishing patient care systems and improving access to treatment, with significant changes in the reimbursement of innovative therapies. However, as the impact of diabetes on the healthcare system continues to grow and advancements are introduced in patient care, there is a pressing need, to continually search for the most optimal solutions to further enhance diabetes care. Objectives: This paper summarize developments of diabetes care in Poland with a special focus on reimbursement of novel therapies introduced in recent 5 years. Methods: We conducted a review of published sources and publications on the management of diabetes care in Poland. This included an analysis of the latest advancements in coordinated care, the collaborative efforts between general practice physicians and specialists, as well as changes in reimbursement policies and other notable progressions in patient-centric care. Furthermore, we analyzed published reports from the National Fund and assessed reimbursement expenditures. Conclusion: The landscape of diabetes treatment in Poland has undergone significant changes in recent years driven by advancements in pharmacological therapies, technological innovations, and healthcare policies. While challenges remain, these changes offer opportunities for further progress in diabetes care in Poland. Continuous efforts to improve patient centered care along with embracing emerging technologies, will contribute to more effective diabetes management and improved quality of life for individuals with diabetes in the country.


Movable retaining pins are generally used in automobile gears, axles, crankshafts, and seatbelt assemblies. The original manufacturing procedures comprise three-stage forming and then drilling. However, a clamp in the drilling process always causes rod surface damage and dents, and the resulting depth tolerance that always exceeds specified dimensions. This study modifies the cold-forging process by replacing the original mechanical drilling stage with one additional forming stage comprised of backward extrusion. The finite element method is applied to analyze and simulate the forming load at each stage, and the Taguchi method is utilized to optimize the product quality in the key second stage. Analytical results show that transforming the original three forging processes and one drilling process into four forging stages overcomes the problems in part manufacturing. Simultaneously, the dimensional accuracy obtained from experiment and numerical analyses shows in good agreement and trusty.


'Institute of Public Health, National Taiwan University College of Medicine, Taipei 10018, and Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, ROC; 2US Environmental Protection Agency, Washington DC, USA; 'Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, USA; 4Department of Legal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.


Immediate-type hypersensitivity reactions occur in genetically-predisposed (atopic) subjects In these subjects, repeated exposure to environmental antigens (allergens) lead to increased immunoglobulin E (IgE) responses, and induce an inflammatory reaction responsible for an increased reactivity of target organs and tissues to allergenic and non-allergenic factors. Recent studies have shown that the allergic state resulted from a dysregulated Th1/Th2 response to allergens. with a shift towards a Th2(like) response Activated Th2 lymphocytes, in blood and lymphoid organs, and at the site of the allergic reaction, produce cytokines that promote IgE synthesis and proliferation, recruitment and (pre(activation of effector cells such as mast cells and basophils, eosinophils and macrophages, fibroblasts, epithelial and endothelial cells; conversely numbers and activation of Th1 lymphocytes are reduced in allergic patients. Most effector cells are sensitized by IgE and, upon activation by allergens and Th2 cytokines, secrete vasoactive, bronchoconstrictive and proinflammatory mediators such as histamine, PAF (platelet-activating factor), leukotrienes, prostaglandins and thromboxanes, responsible for the immediate phase of the allergic reaction. Moreover, effector cells also produce proinflammatory cytokines, responsible for continuation and worsening of the allergic reaction (late phase). Thus, antiinflammatory therapy (ie corticosteroids) is needed, even in patients with moderately severe allergic symptoms. Anaphylactic reactions are also IgE-dependent. However atopy does not represent a major risk factor, except for latex and neuromuscular blocking agents. Anaphylactic reactions result from sudden and extensive degranulation of mast cells and basophils induced by antigen bridging of surface-bound IgE. The major mediator of anaphylaxis is histamine; cardiovascular effects of histamine are probably mediated by endogenous nitric oxide (NO) produced by endothelial cells. PAF, leukotrienes and cytokines could also be responsible for the worsening of severe anaphylactic reactions. Finally, very recent results strongly suggest that an immune-induced dysregulation of the renin-angiotensin system could also be involved in anaphylactic reactions to drugs and hymenoptera venoms. Anaphylactoid reactions are not Ige-dependent: mast cell and basophil degranulation usually result from direct activation or activation by complement-derived factors such as anaphylatoxins. However, pathophysiology and treatment of anaphylactoid and anaphylactic reactions are similar.


Global Navigation Satellite System (GNSS) is the standard generic term for satellite navigation systems that provide autonomous geospatial positioning with global coverage. As of 2007, the United States NAVSTAR Global Positioning System (GPS) is the only fully operational GNSS. Based on bandwidth optimization criterion, the GPS receiver is proposed for solving the carrier/code phase tracking problem. Tracking is the part of the baseband signal processing. The carrier phase tracking loop, the frequency tracking loop, and the code tracking loop are the main three tracking loops in receiver. The architecture of the tracking loops are analyzed and designed with respect to thermal noise and dynamic stress errors. The noise bandwidth in the tracking loop is the most important parameter. The optimization method of noise bandwidth is developed in GPS receiver to provide a better tracking performance. Simulation results show that our proposed method can not only reduce the thermal noise influence but also keep locking in reasonable user dynamic. Keywords-Global Positioning System (GPS), tracking loop, optimal noise bandwidth


We present the chronological series of acoustic emission (AE) signals detected in samples of Westerly granite loaded in different regimes, one of which included a feedback loop between the axial stress and AE activity. In both regimes, the fracturing system evolves without a characteristic energy scale and with the same scaling exponent independently of the applied feedback. The scaling properties of the waiting-time distribution are more sensitive to both the drive control and the stage of fracture process. The revealed period of a lack of time correlation during continuous loading is explained by the transition between the hierarchic levels in the heterogeneous material.


Knowledge on cheetah population densities across their current range is limited. Therefore, new and efficient assessment tools are needed to gain more knowledge on species distribution, ecology and behaviour. Scat detection dogs have emerged as an efficient and non-invasive method to monitor elusive and vulnerable animal species, like cheetahs, due to the dog's superior olfactory system. However, the success of locating scat using detection dogs can be significantly improved under suitable weather conditions. We examined the impact of temperature, humidity and wind speed on detection rates of scat from cheetahs during a scat detection dog survey in Northern Kenya. We found that average wind speed positively influences the scat detection rate of detection dogs working on leash. Humidity showed no significant influence. Temperature showed a strong negative correlation with humidity and thus was excluded from our model analyses. While it is likely that wind speed is especially invalid for dogs working off leash, this study did not demonstrate this. Wind speed could thus influence the success of monitoring cheetahs or other target species. Our findings help to improve the survey and thus maximise the coverage of study area and the collection of target samples of elusive and rare species.


I. Controversies in economic theory are of varying importance, — The explanatory and instrumental aspects of economic theory, 335. — Changing facts and social theories, 337. — II. The place of "facts" in economic controversy, 339. — The relation of psychology to economic theory, 343. — Mechanistic and organic social theories as a source of controversy, 347. — Difficulties arising out of the organic analogy, 349. — III. The philosophy of "social control," 351. — IV. Chaotic possibilities of "viewpoints" in economics, 355. — Uses and limitations of the mechanistic view, 356. — Types of new "approaches" to economics, and their limitations, 359. — Sacrifices entailed in eliminating controversies, 360. — The scientific character of economics, old and new, 362.


This article explores migrant disappearances and border deaths at the Greek borderlands through the notion of forensic  bordering. Based on fieldwork in the Evros region, Athens and its surroundings, and on the island of Lesvos, I argue that  disappearance and non-identification in the event of death are effectively border violence by other means. Three forms of symbolic and political post-mortem border violence are then explicated: the act of disappearance, the act of non-identification, and the act of denying proper mourning. Crucially, this article unpacks the underlining logic that, if migrants from Africa, Asia, and the Middle East are not supposed to cross the border in the first place, their existence and, ultimately, their equal humanity can be similarly denied in death. If the forensic sciences are generally perceived positively as means to provide answers, closure, accountability, and truth, forensic bordering seeks to do the exact opposite, rejecting accountability and employing silence as a deterrence.


: We discuss monotone numerical methods for fractional and nonlocal HJB equations in strongly and weakly degenerate cases. These equations are dynamic programming equations of optimal control of SDEs driven by pure jump Levy processes. We discuss very precise (fractional) error bounds for diffusion corrected difference-quadrature methods. By precise fractional rate we mean, the convergence rates depend optimally on the order of the nonlocal operators. For weakly degenerate nonlocal equations, we obtain stronger regularity type estimates for both the viscosity solutions and numerical approximations. As a result, we show the improvement in error bound for the schemes compared to strongly degenerate cases.


This paper investigates the syntax of polarity particles 'yes' and 'no' as responses to negative utterances such as negative questions and assertions. It has been noted by Krifka (2013), among others, that negative utterances can be responded to in four different ways, such that 'yes' and 'no' are both part of positive or negative responses. We argue that 'yes' and 'no' in negative responses to negative utterances are derived from feature checking/valuation between the polarity particle and the TP-internal Pol head, followed by TP ellipsis. By contrast, 'yes' and 'no' in positive responses to negative utterances are immediately followed by the empty TP, which recruits its antecedent semantically from the propositions denoted by the preceding negative question or assertion. It is shown that the line of our analysis musters empirical support from Goodhue and Wagner's (2018) recent analysis of the interaction between polarity particles and intonation, in that unlike the unmarked cases that employ syntactic feature checking/valuation, the marked cases of polarity particles that rely on semantic binding and composition are bound to bear the peculiar intonation of contradiction contour.


In this study, three varieties of rice including Tarom, Anbarbo and Hashemi were selected and their heavy metals Content were analyzed. Subcritical water was used to provide rice bran extract at temperatures 100 and 120 ° C. In order to provide grape juice treatments, we used 5, 10, 15 and 20 % of extract in the formulation of red grape drink. samples which had packed and pasteurized, kept in the refrigerator for three months, then Rheological measurements were carried out by using Brookfield rheometer at 5°C .Physical and chemical characteristic evaluated by using SPSS software and one-way ANOVA and Duncan test >P) 0.05). Increasing temperature results in increasing rice bran extraction in subcritical water extraction method. Investigation of rheological properties showed that increasing in amount of rice bran extract cause to decrease consistency coefficient and increase flow index. Consistency coefficient of treatments during storage indicated that consistency coefficients were increased for all treatment


ABSTRACT Ever since an intense theoretical debate over a decade ago, the concept of heterogeneity has had a well-established place within poststructuralist Discourse Theory. It captures the interactions between the heart of the space of representation and its margins, between excluded excess and manifest presence; and conceptualizes particularities, differential remainders, and discursive exteriority. The analytical implications of heterogeneity remain underexploited, however. This contribution makes the case that one way to operationalize the notion of heterogeneity in empirical research is by tracing its strategic effects. Since heterogeneity constitutes 'the primary terrain within which homogeneizing logics operate', heterogeneous dynamics like the 'incorporation of new demands' and 'the exclusion of others who were previously present' affect and shape the availability and feasibility of political strategies. This contribution first provides an extensive definition of heterogeneity drawing on the original debate that gave the concept prominence. An approach that captures and explains the strategic effects of heterogeneity is then developed through the integration of heterogeneity into the logics framework. Finally, this approach is illustrated through an exploration of the politics of international trade.


The Small Business promotes productive development of a country. The performance impact of these organizations largely in compliance with macroeconomic objectives and economic performance in promoting the welfare of society. The implementation of management systems help organizations to develop efficient processes and sorted so that facilitate their production and operational activities. The need to implement these management systems in the areas of quality and environmental management has evolved such that it has become a requirement for an organization to remain productive in a particular profession and to comply with legislation and regulations that affect a particular social group . This paper aims to show the impact it has had to implement quality systems and environmental management in Small and Medium Enterprises as a result of an exploratory study in Bogota Colombia


A method is proposed for tracking objects in face with varying viewpoints and partial occlusions. A low-dimensional subspace is built to model the appearance of the target. And each image sample is presented as a coefficient vector in the subspace. A collection of image patches are sampled as the candidates of the object image region in the current frame, and their likelihoods of being the object are evaluated resorting to the reconstructions from the corresponding coefficient vectors. The image patch with highest likelihood is selected as the object image region. Finally, the subspace is incrementally updated based on the coefficient vectors, which are assigned with the temporal weights to enhance the adaptability of the tracker. Experimental results show that our proposed method can locate the target accurately even when the target undergoes changes in viewpoints and partial occlusions.


Given its size, reputation, and dominance of the retail sector, Wal-Mart has quickly become one of the most controversial companies of our time. Despite its considerable coverage in the news and popular press, relatively little has been written about Wal-Mart in academic, peer-reviewed books and journals. Using data on Wal-Mart that record the opening date and location of every store in the United States between 1972 and 2001, I will analyze the relationship between Wal-Mart and a number of variables that measure political engagement. I find Wal-Mart stores are correlated with decreasing voter turnout, lower participation in political activities, less philanthropy, and declining social capital. The pattern is observed in four different data sets based on county and individual-level data. The results imply Wal-Mart has a measurable impact on communities in the United States that reaches beyond prices, income, and employment. Big box retail, it seems, comes at a cost. Lower prices and all that comes with them hold important consequences for political participation.


In multi-core processors, Last Level Cache(LLC) can reduce the speed gap between the memory and the core. For this reason, LLC has big impact on the performance of processors. LLC is composed of shared cache and private cache. In computer architecture community, most researchers have mainly focused on the management techniques for shared cache, while management techniques for private cache have not been widely researched. In conventional private LLC, memory is statically assigned to each core, resulting in serious performance degradation when the workloads are not fairly distributed. To overcome this problem, this paper proposes the replacement policy for managing private cache of LLC efficiently. As proposed core-aware cache replacement policy can reconfigure LLC dynamically, hit rate of LLC is increases drastically. Moreover, proposed policy uses 2-bit saturating counters to improve the performance. According to our simulation results, the proposed method can improve hit rates by 9.23% and reduce the access time by 12.85% compared to the conventional method.


This article describes the identification through the use of images and interactive remote control technology to achieve metallurgical industry,mineral aggregate automatic sampling,which greatly eased the sharp increase due to mineral aggregate throughput,artificial factors fraud violations and other causes of the rising production Disconnection management,reduce labor intensity and improve the efficiency of inspection and analysis system.