. In this work, we present a tool for the automated super optimization of Armv8.1-M Helium assembly on Cortex-M55. It consists of two parts: Firstly, a generic framework SLOTHY – Super (Lazy) Optimization of Tricky Handwritten assemblY – for expressing the super optimization of small pieces of assembly as a constraint satisfaction problem which can be handed to an external solver – concretely, we pick CP-SAT from Google OR-Tools . Secondly, an instantiation HeLight 55 of SLOTHY with the Armv8.1-M architecture and aspects of the Cortex-M55 microarchitecture. We demonstrate the power of SLOTHY and HeLight 55 by using it to optimize two workloads: First, a radix-4 complex Fast Fourier Transform (FFT) in fixed-point arithmetic, fundamental in Digital Signal Processing. Second, the instances of the Number Theoretic Transform (NTT) underlying CRYSTALS-Kyber and CRYSTALS-Dilithium [SAB + 22],[LDK + 22], two recently announced winners of the NIST Post-Quantum Cryptography standardization project [NIS16].


Julius Caesar William Shakespeare That tide, in our understanding of the origins of human insulin-dependent diabetes, broke on the shores of Europe in 1974. In the same year came reports that established the genetic basis of this disease (through HLA genes) and detection of a disease-associated biomarker (islet cell autoantibodies) [1,2]. The consequent altered awareness of disease pathogenesis suggested a change to a less therapeutically-orientated nomenclature, whence 'Type 1 diabetes'. Juxtaposing evidence that diseased islets show inflammatory changes, that genetic susceptibility involves immune response genes and that autoantibodies are good disease biomarkers led logically to the conclusion that this is an inflammatory, probably autoimmune, disease. Attempts to modify the disease process were initiated by Stiller et al. (cyclosporin) [3], Elliott et al. (prednisolone) [4], Assan et al. (cyclosporin) [5] and, dramatically, by Leslie et al. [6]. If the disease was autoinflammatory in nature and acute in presentation then, they all argued, aggressive immunosuppression might cure it. For Leslie et al. [6], there was no need for controls because only a cure could justify the character of the regime (high-dose steroids, azathioprine, anti-lymphocyte globulin and plasmapheresis). None of them worked, or rather, if there was an effect it was short-lived. That flood of data, on the pathogenesis of Type 1 diabetes, has continued unabated and is highlighted in a Position Statement in this edition. The authors emphasize two features. First, the evidence that the critical environmental events causing Type 1 diabetes operate early in life [7]. They note our striking ability to predict the disease with a high degree of accuracy; that prediction being based on a combination of genetic risk (HLA-risk alleles), autoantigen-specific autoantibodies and target-organ function (loss of insulin secretion). Second, they encourage the continuing support of longitudinal studies of population, family, twin and birth cohorts, on which this evidence is based [8]. But the purpose of prediction is prevention, and there is the rub. That flood did not lead on to fortune. We still cannot prevent, let alone modify, this disease. Even the somewhat vainglorious targets of cure in yesteryear have been replaced by the slightly effete prospect of improving C-peptide (that is, insulin) secretion or reducing insulin dose requirement [8]. The authors of the Position Statement reflect much of the thinking in the scientific community when they seek an answer through antigen-based immunomodulation. Such therapy holds out the prospect of success, with limited collateral damage in the form of side effects. But do these therapies work? After years of futile effort, compounded by some recent failures, it is inspiring, but hardly warming, that the authors wish to bring forward a mechanistic approach to designing future prevention trials that 'must include antigen-specific tolerance approaches'. Yet it is the very success of insulin therapy, with new syringes, needles, pumps and insulins, as well as improved outcome, which has stayed our enthusiasm for the aggressive treatment of children. For future successwith immunomodulation,wemayhave to take a courageous step back into pre-disease. Only then may the tide turn.


Propagator for spinning particle described in the Feshbach–Villars formalism is set up using fermionic coherent state path integral. The fermionization of the charge-spin symmetry is presented following the Schwinger recipe. The explicit calculations are done in the free case and magnetic interaction using the Foldy–Wouthuysen tranformation. The spectrum and wave functions are deduced.


Asian watergrass (Hygroryza aristata) is an herbaceous glabrous aquatic-rooted floating grass naturally growing in the tidally inundated coastal marshes, beels and canals. The ecology and growth performance of Asian watergrass were evaluated in the coastal wetland (CWL), in an artificially created canal (ACC) within the coastal wetland and in the university research ponds (URP). The study was conducted with three replications in each area. The proximate compositions of the leaves, roots and stems of the grass were determined. Important water and soil quality parameters were found favorable for the growth and production of Asian watergrass. The growth performance and total production of the grass were significantly higher in ACC (length: 2.78 m and weight: 386.86 metric ton ha−1) in comparison with those in CWL (2.36 m and 256.67 metric ton ha−1) and URP (2.22 m and 137.10 metric ton ha−1). Higher content of crude protein was found in leaves (17.49%) followed by roots (12.17%) and stems (9.39%), while the minerals (ash) and fiber contents were found higher in stems (25.68% and 9.53%) in comparison with those in leaves and roots. The findings indicate that the coastal wetlands of Bangladesh having available nutrients in both water and soil are suitable for higher growth and production of Asian watergrass. Considering the nutrient compositions, the Asian watergrass may be an important potential source of feed ingredient that may be used as fish feed in aquaculture throughout the world.


In our 'rights society' we seek to vindicate and protect, through our legal and political institutions, those rights we view as fundamental to human flourishing. However, changing social mores and limitations in our ability to relieve (or cope with) certain health conditions have resulted in unanticipated demands being placed on those rights; patients rely on them in seeking death, which is not normally associated with flourishing and which is largely antithetical to rights and health regimes aimed at promoting or preserving human life. The recent European Court of Human Rights decision in Affaire Haas v Suisse demonstrates the challenge of relying on rights to achieve death. Haas is the most recent case aimed at articulating the scope of individual autonomy and the duties of government in assisted dying scenarios. Once again, the applicant has invoked rights to achieve 'a good death', and in doing so has called upon public authorities to take some action to assist him. This paper considers Haas in the context of its predecessor European case, Pretty v United Kingdom, offering some observations about how they differ and why Haas had little chance of success, and was correctly decided.


A formal solution of the scattering field from a rough interface has been derived. Under the Bass perturbation theory, both waveguide and nonwaveguide (half‐space) scattering from a rough interface (the sea bottom) can be calculated analytically. By using an identical definition of ''scattering coefficient,'' a relation between the waveguide scattering (the modal S matrix) Mljs and the nonwaveguide scattering (conventional plane‐wave scattering) coefficient ms has been found: Mljs= (2π)2ms/‖V(θl)V(θj)‖, where V(θl) and V(θj) represent the reflection coefficients of the plane interface for the modal incident angles θl and θj, respectively. Consequently, based on this relation, the ms data measured in the conventional sense (half‐space) can be bridged into a shallow water reverberation prediction or vice versa.


Perovskite solar cells attract great attention due to its rapidly increasing efficiency. Conventional structure of perovskite solar cell contains FTO glass substrate, compact TiO2 layer, mesoporous TiO2/CH3NH3PbI3 layer, hole transport- ing material layer and Au counter electrode. In this work, we fabricated perovskite solar cells with the above conventional structure. The mesoporous TiO2 layer thickness are 500, 350, 150 and 100 nm. Thickness of CH3NH3PbI3 capping layer is about 300 nm. The perovskite films and solar cells were characterized by SEM, XRD, UV-Vis absorption spectrum, photo- current-photovoltage characteristics and electrochemical impedance spectra. XRD patterns of the perovskite films are similar, indicating the complete transfer from PbI2 to CH3NH3PbI3. Statistical results of short-circuit current, open-circuit voltage, fill factor and power conversion efficiency are compared, revealing that as mesoporous TiO2 layer thickness increasing, both photovoltage and fill factor decrease whereas short-circuit current slightly increases. Solar cells with thinner mesoporous TiO2 layer can give higher efficiency. Besides, the devices with 100 and 150 nm mesoporous TiO2 layers can present the average efficiency of 15%. The decrement of efficiency is supposed to be caused by stronger carrier recombination. Electro- chemical impedance spectra and current-voltage characteristics under dark condition were applied to characterize the carrier recombination process. Nyquist plots demonstrated an increment of the recombination as the mesoporous TiO2 layer thick- ness increases. Charge transfer resistances were obtained by fitting Nyquist plots. The charge transfer resistances of solar cells with 100 and 350 nm mesoporous TiO2 layer decrease with bias voltage exponentially in similar slope, indicating that this change of recombination do not influence the diode quality factor. Reverse saturated current density was obtained by fitting dark current-voltage curves. The reverse saturated current densities have positive correction with mesoporous TiO2 layer thickness. As a conclusion, the change of the recombination is caused by reverse saturated current density rather than diode quality factor. Further investigation revealed that the devices with thinner mesoporous TiO2 layers exhibit relatively stronger hysteresis behavior. 15.56% of certified efficiency has been obtained for the perovskite solar cell with 150 nm-thickness mesoporous TiO2 layer. Keywords perovskite; solar cell; carrier recombination; TiO2; film thickness


Extracted from text ... VOLUME 3 NUMBER 2 ? JUNE 2006 57
SA JOURNAL OF DIABETES & VASCULAR DISEASE EDITORIAL
Poor management of hypertension is a worldwide problem
with few countries achieving acceptable levels of blood
pressure control. In South Africa, hypertension is the dominant
risk factor for stroke, coronary heart disease, heart failure and
chronic kidney disease.1, 2 The reasons for inadequate control
are complex, but health-professional inertia with failure to
implement existing guidelines is a major contributing factor.
Additionally, in South African there are an abundance of
hypertension guidelines or protocols developed by professional
societies, medical aids, the Council for Medical ..


Research indicates that good front-end planning (FEP) results in the achievement of higher levels of project performance. By facilitating collaboration among stakeholders in diverse locations with the use of workflow-enabled processes, such pressures can be reduced, and the overall process and results of FEP can be improved. With these goals, a front-end planning tool (FEPT) has been developed as support for owners and major contractors who are engaged in front-end planning. This paper presents the new FEPT and describes how it has been used for construction megaprojects in the nuclear power, oil and gas, and mining industries. The paper begins with the definitions related to and an explanation of the general process for implementing and applying the FEPT and then describes and analyzes how the FEPT was applied in case study projects in order to test its validity. The results indicate that the FEPT increases the efficiency and effectiveness of front-end planning for the megaprojects studied and that it has the potential to produce similar results for other megaprojects.


Artificial hypogravity was created by having subjects remain in a supine position while undergoing rotation in an artificial gravity simulator. Various cardiovascular variables, such as heart rate, cardiac output, thoracic electric impedance, and blood pressure were measured. Results indicated that the hypogravity force produced a headward fluid shift, as seen by a decrease in thoracic impedance, which triggers regulatory neuroendocrine mechanisms. These findings are presented and discussed.


This manual describes the worksheet version of the Food Aid and Food Security Analysis System (FAFSAS) for Honduras. It details the step-by-step procedure of using the analytical system for policy analysis and includes a conceptual framework and model that combine FAPRI data with country-specific information, described in a series of equation.


17.8 pdnm . km. The resulting chirped pulses are modulated in a second lithium niobate modulator. Driving voltages of 4.5 V were used to generate 32 channels of data, each at a bitrate of 50 Mb/s, for an aggregate bitrate of 1.6 Gb/s, operating in a return-to-zero (RZ) format. The 32 channels are spaced by 1.2 nm. The output spectrum, Fig. 2b, with the data modulator encoding a square-wave (all RZ channels on) yields a spectral bandwidth of 30 nm after passing through the modulator, so that ofthese 32 channels, only20 fall within the gain bandwidth of the EDFA, and contain sufficient power to carry a transmission. By adjusting the modulator phase and pulse duration, the wavelength and spacing of the WDM channels can be dynamically allocated, on a bit-by-bit basis. The quality of the transmission system was determined by measuring the bit-error rate (BER) as a function of received power. The function of the WDM router was obtained by use of a tunable bandpass filter, having a spectral bandwidth of 1.1 nm. The BER for a single channel transmitting (Fig. 3, lower) indicates a l o r 9 BER receiver sensitivity of -40 dBm. With one adjacent channel transmitting the same pseudorandom bitstream, offset by 1024 bits (Fig. 3, upper), the performance is degraded by crosstalk. The difference in receiver sensitivities indicates a crosstalk power penalty of 1 dB. Significantly better crosstalk performance can be obtained by use of a filter bandwidth of approximately half the channel spacing. In summary, we demonstrate a chirped WDM transmitter capable of delivering a transmission of 20 channels of 50 Mb/s data for a local access network. The data modulator simultaneously defines the wavelength channels, and encodes data onto them, making this transmitter extremely flexible in assigning wavelength channels to the transmission. Moreover, the transmitter is composed entirely of technologically mature components. 1. M. C. Nuss, W. H. Knox, U. Koren, Electron. Lett. 32, 1311 (1996). CF15 11:30 am 20 I


The basement units of the study area are Paleozoic-Mesozoic Keban metamorphics and Late Cretaceous Elazig magmatics. As a result of tectonic events caused by final collision in Middle Maastrichtian, all these basement units were juxtaposed, uplifted, eroded and acted as a source area for the Maastrichtian-Paleogene basins. Upper Cretaceous Paleogene deposits were systematically sampled in order to determine their ages and lithologies. Due to new age findings and stratigraphical positions the marine units were identified as; Harami, Seske and Kirkgecit formations. Late Oligocene-Early Miocene Alibonca formation and Pliocene Karabakir formation are the other units of the study area. Maastrichtian-Thanetian Harami formation is formed by grainstone intercalated with sandstone at the bottom and white limestone at the top. Early Lutetian Seske formation consists of conglomerate at the bottom and much nummulitic, carbonate cemented sandstone with ophiolitic fragments at the top. Kirkgecit formation consists of sandstone-siltstone-limestone intercalation, and it is early Bartonian early Chattian. Late Chattian-middle Burdigalian Alibonca formation consists of conglomerate at the bottom, reefal limestone in the middle and clayey limestone intercalated with algal limestone at the top. Pliocene Karabakir formation is formed by conglomerate-mudstone and locally by intercalations of pyroclastics and lavas. Pertek Andesite and Basalt Members are both vertically and laterally transitional with sedimentary lithologies of the Karabakir formation. There is no data to date the lithology; however, it was assumed that it had been Pliocene in age according to the lithostratigraphical succession. In the study area, macrotectonic events were experienced in Late Cretaceous, Early Eocene, middle-late Lutetian, Middle?-Late Miocene and in the Latest Pliocene. During the last tectonic phase, the Anatolian plate bounded by the East Anatolian Fault (EAF) in E-SE began to move westward, and the right lateral strike slip Pertek Fault activated in the study area.


The invention discloses a concrete composition with hyperfine carbonate rock powder and allocating method, which comprises the following parts: polyvalent powder, additive, rough aggregate, fine aggregate and water, wherein the scale of polyvalent powder in per cubic meter concrete is 300kg/m3-550kg/m3, which contains 70kg/m3-150kg/m3 hyperfine carbonate rock powder, 20%-100% cement and mineral material.


The invention discloses a rolling public bench. The rolling public bench comprises a bench surface, bench legs and hand rockers, wherein the bench surface is of a caterpillar structure and is connected with the hand rockers on the bench legs; buckle switches are arranged on the hand rockers and can be used for fixing the bench surface and enabling the bench surface to not roll.


In order to improve the working life of extractive pump,3 kinds of materials which include carbon steel,4-6%chrome steel and alloy steel and corresponding heat treatment process used for them are chosen.Fricative pairs are matched to be tested under the same working condition.A comprehensive analysis of test results indicates that fricative pairs consisting of nickel-plated carbon steel/chrome-plated carbon steel and 4%-6%CrN steel is the better combination.


Micro-surfacing technology is used to treat early diseases on Henan S333 Highway.The raw materials and their choosing basis are discussed in detail,and the mixture proportion is determined through experiment. Practice shows that the application of micro-surfacing technology in this project improves the slip resistance performance; increases the texture depth;eliminates cracks,net cracks,rutting and other apparent diseases.


A gravel storage building and distribution facility was planned for construction at the West Parr yard located in the Port of Richmond, California. The general subsurface profile consists of a fill layer overlying a lens of young bay mud, a soft to med stiff silty clay and clayey silt. Below that lied a deeper dense clayey sand and stiff clay layer. The ground water table elevation observed in borings was approximately 7 to 10 feet below the current ground surface. Loads in excess of 3,500 psf would be applied to these strata and relatively tight settlements tolerances were necessitated to maintain functionality of the building's conveyor systems. Deep pile foundations were considered but due to the excessive costs and operational challenges, it was elected to implement a ground modification system, jet grout columns, to transfer the loads through the undocumented fill and young bay muds, to the more competent, stiff clay layer below.


The families of the Carmo village, in the interior of the state of São Paulo SP Brazil, were analyzed through family and child anamneses, photos and drawings of houses, interviews with school, day-care and health officers. Carmo village, originally founded by a group of slaves (quilombo) and characterized by an extended family network, has lost its capacity to produce agricultural jobs. Analysis focused on sharing family concerns, on the inhabitants' involvement with non-governmental organizations and with public authorities. Four family types were identified according to place connections and attachment: non-connected and non-attached families; connected and attached families; connected and non-attached families; non-connected and attached families. Insertion modality in the social and familial context is a consequence of past histories and indicates the success and failure of the family enterprise.


Split-thickness skin grafts (STSGs) are the mainstay of skin replacement therapy but fail to adequately reproduce basic skin functions and subject patients to new, open wounds that can cause significant pain and scarring. Full-thickness skin grafts (FTSGs) have improved cosmetic outcomes and better recapitulate skin functions, but few sites can serve as donors and requirement for "take" is greater. Prior research has shown that full-thickness skin column (FTSC) harvest results in improved healing of the injured site and decreased morbidity of the donor site at 10% harvest density. This study aims to determine the maximal harvest density of FTSC donor sites.

 Ten donor sites were created on the dorsum of anesthetized swine (Sus scrofa domestica). STSG donor sites were harvested with a dermatome (12/1000 inch) and compared to FTSC donor sites with the highest possible harvest ratio of sixteen 1.5mm-diameter skin columns/1cm2 (28% harvest density). Donor site morbidity was assessed via re-epithelialization, contraction, pigmentation, number of hair follicles, and scar thickness on post-burn day (PBD) 7, 14, 21, 28, 60, and 90.

 There were no significant differences in re-epithelialization or contraction between FTSC and STSG donor sites. STSG donor site pigmentation was significantly decreased as compared to control on all assessment days (p=0.0161, 0.0003, 0.0031, 0.0095, 0.0244, respectively), and remained significantly hypopigmented as compared to FTSC starting at PBD 14 (p< 0.0001). Pigmentation was decreased for FTSC donor sites at PBD 14 (p=0.0204) but significance was lost by PBD 21. Both FTSC and STSG donor sites showed significantly fewer hair follicles as compared to control at PBD 7 (p=0.0011, 0.0003, respectively). On PBD 21, STSG had significantly less hair follicles as compared to FTSC donor sites (p=0.0010). This resolved by PBD 28. FTSC scars were significantly thicker than both control and STSG at PBD 28 (p=0.0348, 0.0038, respectively) and PBD 60 (p=0.0174, 0.0329, respectively). This significance was lost by PBD 90.

 No statistically significant differences were seen in re-epithelialization and contraction between FTSC and STSG donor sites. STSG were hypopigmented as compared to FTSC donor sites and had significantly less hair follicles at day 21. FTSC donor site scars were significantly thicker than STSG. Although decreased donor site morbidity has been observed at lower harvest densities (10%), these results were not seen at 28%, which likely exceeds the optimal harvest density.


The Single-phase AC Regulator on Base of Bidirectional IGBT Switches In the work one of the methods for regulation of sinus shape AC voltage for middle-power loads with activeinductive character is observed. Such a regulator keeping output voltage of sinus shape must be fast-reacting and work in closed-loop system. It's shown, that for providing such features Buck and Boost pulse regulators can be applied. The only difference from DC pulse converters is that electronic switches in the system must be with bidirectional conductivity. For this reason an IGBT transistors can be applied with implemented in structure reverse diodes and if such two transistors are connected in series and with contrary conductivity then at activating both one of them will be in on-state. Realization of AC regulators with such switches is described in the work. Results of computer modeling also are given. Output voltage ripples are investigated on subject of their range and efficiency of filtering equipment on LC base. Such regulators can be applied for instance in electrical transport self supply systems.


Line loss of rural distribution power net takes a large proportion in line loss of the entire power system,so it has a significant meaning to analyze theoretical line loss of rural distribution power net and reduce loss by using reasonable method. Aiming at current situation of the theoretic line loss calculation in rural distribution power net,calculation method of the theoretic line loss is analyzed,theoretic line loss calculation and analysis system is designed,and the influential factors of line loss were also summarized in detail.


The whiplash injury develops the various symptoms, in which those due to the vertebrobasilar insufficiency are particularly various and complicated. However, few literatures to explain the mechanism of this vertebrobasilar insufficiency in the whiplash injury have published, so far. We performed the brachial angiography to all the patients who had had the clear history of the whiplash injury and its symptoms. Almost all the angiograms showed the diffuse spasm of the vertebral arterial system, while some showed the stenosis of the vertebral artery at its origin, and the displacement of the artery in its course. The vertebral nerve including the sympathetic nerves in it is diffusely innervating the vertebral arterial systems. The injury to the neck probably causes the excitement of the crvical sympathetic ganglions which brings about the diffuse spasm of the vertebral arterial systems. We summarized the mechanism of the vertebrobasilar insufficiency in whiplash injury as follows:


The present invention, tetrahydroquinoline sulfonamide compound, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods for promoting RORγ activity, IL-17 method of the amount increased in a subject, as well as cancer and other medical use of such compounds It provides a method of treatment of disorders.


Gating The breathing cycle was divided into eight parts by using a respiratory signal. This signal was acquired by laying a belt around the patient's waist with a black disc containing a white spot in the center. The position of this spot was tracked with the help of a video camera. A light emitting diode (LED) was used for synchronizing the respiratory signal with the listmode PET data. The PET data is then sorted based upon the amplitude of the respiratory signal. Detailed comparison of different gating methods have shown that the amplitude based gating is superior to other forms of gating. The eight gates, which represent eight respiratory phases, are then reconstructed individually without attenuation correction.


With the rapid development of urbanization and population growth, the ecological environment in the Yellow River Delta has undergone significant changes. In this study, Landsat satellite data and Google Earth Engine (GEE) were utilized to dynamically evaluate the changes in eco-environmental quality in the Yellow River Delta region using the remote sensing ecological index (RSEI). Additionally, the CASA model was used to estimate net primary productivity (NPP) and explore the relationship between vegetation NPP, land-use and land-cover change (LUCC), and eco-environmental quality to reveal the complexity and related factors of eco-environmental quality changes in this region. The results show that: (1) Over the past 20 years, the eco-environmental quality in the Yellow River Delta region has changed in a "V" shape. The eco-environmental quality near the Yellow River Basin is relatively better, forming a diagonal "Y" shape, while the areas with poorer eco-environmental quality are mainly distributed in the coastal edge region of the Yellow River Delta. (2) The response of vegetation NPP to eco-environmental quality in the Yellow River Delta region is unstable. (3) Urban construction land in the Yellow River Delta region is strongly correlated with RSEI, and the absolute value of the dynamic degree of land use is as high as 8.78%, with significant land transfer changes. The correlation between arable land and RSEI is weak, while coastal mudflats are negatively correlated with RSEI, with the minimum absolute value of the dynamic degree of land use being −1.01%, and significant land transfer changes. There is no correlation between forest land and RSEI. Our research results can provide data support for the eco-environmental protection and sustainable development of the Yellow River Delta region and help local governments to take corresponding measures.


Path integral policy improvement (PI2) is a data-driven method for solving stochastic optimal control problems. Both feedforward and feedback controls are calculated based on a sample of noisy open-loop trajectories of the system and their costs, which can be obtained in a highly parallelizable manner. The control strategy offers theoretical performance guarantees related to the expected cost achieved by the resulting closed-loop system. This paper extends the single-agent case to a multi-agent setting, where such theoretical guarantees have not been attained previously. We provide both a decentralized and a leader-follower scheme for distributing the feedback calculations under different communication constraints. The theoretical results are verified numerically through simulations.


The article shows that Azerbaijan belongs to modern countries with a high rate of economic development, therefore, at the current stage of evolutionary development as a state, it has embarked on the path of a new level of improvement. This shows how in recent years the economic situation in the republic has contributed to significant economic growth, an increase in the level of both the social welfare of the state and the modernization of the socio-economic infrastructure of the republic as a whole, resulting in a diversified structure of the economy.
The article reveals an assessment of the current state of industrial enterprises in Azerbaijan, as well as an analysis of the directions and trends of their development. The assessment of the current state was carried out by studying resolutions, orders, acts, strategies for long-term economic development and other documents with the help of which it is possible to assess the quantitative composition of industrial enterprises.
The determination of trends in the development of industrial enterprises was carried out using the analysis of the "Main directions of the Strategic Roadmap for the National economy and the main sectors of the economy", approved by the decree of the President of the Republic of Azerbaijan Ilham Aliyev on December 6, 2016.
The analysis carried out in the article made it possible to determine the priority directions of sustainable development of industrial enterprises, more precisely: improvement of production; scientific, technical and innovative development; implementation of programs specified in the concept of the "Strategic Roadmap for the development of the national economy", etc. The main priority of industrial enterprises is innovative development, which includes all of the above, and NTR is presented here as a certain "layer", a means of realizing prospects. Based on the above, a logical chain of the main directions of development of industrial enterprises is constructed and their justification is given.
The article reveals the investment activity of the country's economy, as well as analyzes the level of foreign investment.
At the end of the article, the key directions of the formation of the innovative economy of the country are indicated, the priorities of industrial development and conclusions regarding them are indicated.
Keywords: industry, business, non-oil sector, machine-building complex, sustainable development, pandemic, investment, diversification, development strategy, innovation.


This chapter summarizes Beijing's policies and techniques for managing different subsets of the Overseas Chinese (OC) over the last three decades. It argues that the Chinese Communist Party's (CCP)'s qiaowu methods have successfully unified cooperative groups for its own interests through cooptation, while other methods have sought to prevent hostile ones from eroding its grip on power. Referring to Gamson's typologies of cooptation, social management, and control techniques, qiaowu has sought to bring in, influence, subsume, or isolate targeted groups of OC for particular outcomes. By 2008, threats such as the pro-democratic and Taiwanese pro-independence movements had been largely subverted, and remain only a partial cause of concern. Similarly, Falungong (FLG) have been largely isolated and discredited, while the Tibetan and Xinjiang separatist movements find themselves overwhelmed by a wave of Chinese nationalism.Keywords: Beijing; Chinese Communist Party (CCP); Falungong (FLG); Gamson; Overseas Chinese (OC); Tibetan; Xinjiang


The Internet of Things (IoT) invades our world with billions of smart, interconnected devices, all programmed to make our lives easier. For educators, teaching such a vast and dynamic field is both a necessity and a challenge. IoT-relevant topics such as programming, hardware, networking and artificial intelligence are already covered in core computing curricula. Does this mean that fresh graduates are well prepared to tackle complex IoT problems? Unfortunately, nothing could be further from the truth. The problem is that IoT devices are complex systems, where software, hardware, and humans interact with each other. From this interaction, unique behavior and hazardous situations can emerge that might easily stay undetected, unless systems are analyzed as a whole. This paper presents two differently flavored courses that teach IoT using a holistic, system-centric approach. The first is a broad introduction to Pervasive Computing, focused on the intelligence of "Things". The second is an advanced course that zooms on the process of testing a software-intensive system. The key characteristics of our approach are : (1) teaching only the bare essentials (topics needed for end-to-end engineering of a smart system), (2) a strong, hands-on project component, using microcontroller-based miniature systems, inspired by real-life, and (3) a rich partnership with industry and academic idea incubators. Positive student evaluations gathered during the last five years demonstrate that such an approach brings engagement, self-confidence and realism in IoT classrooms. We believe that this success can be replicated in other courses, by shifting the focus on different IoT-relevant aspects.


Epithelial junction formation and morphogenesis requires the GTPase-activating protein SH3BP1 and the F-actin–capping protein CapZ to guide Cdc42 signaling and cytoskeletal dynamics.


Objective To investigate the treatment of spontaneous brain stem hemorrhage and analyse the factors affecting its prognosis. Methods The clinical data of 37 patients with spontaneous brain stem hemorrhage were analysed retrospectively. The factors affecting its prognosis were discussed in combination with the relative literatures in the patients with spontaneous brain stem hemorrhage. Result Of 37 patients with spontaneous brain stem hemorrhage, 9 were healed, 15 improved, 6 survived in the vegetative status and 7 died. Conclusion The major factors which affect the prognosis include the volume of hemorrhage, and conscious disturbance levels in the patients with spontaneous brain stem hemorrhage.


In the analytical review of the literature the main stages of development of biodegradable magnesium alloys in surgery and traumatology were discussed. The analysis revealed the main problems: there is no way to control the speed of the biological resorption alloys, the effects of products of magnesium degradation on the tissues and the organism in general are not studied, there is no information on the characteristics of the regeneration of bone tissue when implanted magnesium implanted magnesium alloys Materials for osteosynthesis with metal clamps made of steel X18H9T are used in 25,0-52,2% of cases, the corrosion of fasteners reaches 18-21%. Corrosion of the metal clips leads to the increase of the concentration of iron, chromium, nickel and titanium in the surrounding tissue. Electrochemical processes in metallic implants occurs due to their structural and chemical inhomogeneous. The microstructure of stainless steel is presented by differently oriented grains. Therefore, the question remains relevant to finding biodegradable materials suitable for implants for osteosynthesis, which could be completely metabolized by the organism, without causing of the pathological effects on the surrounding tissue and the body. The property of magnesium metal dissolved in the tissues of a living organism is known since the 19th century. Payr suggested the use of magnesium metal needles for the treatment of angiomas, in order to achieve thrombosis surrounding the tumor. In 1937 Lambotte made a post in the French Surgical Academy on the application of the osteosynthesis of the shin bone clamps with alloy Dow-metal (magnesium - 92% Aluminum - 8% + traces of manganese), made in the form of loops and screws. In 1938, Earl D. Mc.Braid and published their positive experience with plates and screws made of material similar in composition to the Dow-metal for osteosynthesis of fractures of the arm and forearm bones. Magnesium alloys may be used as a material for various types of implants for osteosynthesis in traumatology and orthopedics. As the analysis of scientific papers over the past decade, the number of scientific articles devoted to the study of the properties of magnesium alloys and their effect on bone formation, as well as their use in osteosynthesis has grown significantly. Implants which are based on magnesium, may have several advantages over bioinert metal alloys, polymers, and bioceramics. They are not toxic, not carcinogenic, the mechanical properties of a structure close to the cortical bone, and may have osteoinductive and anti-bacterial action. Also, there is no need for a second surgical intervention. The main problems to be addressed, in our view, are as follows. 1. Need to examine the nature of -bone formation in the fracture in the presence of the implant based on magnesium alloy. 2. To examine the impact of products of magnesium degradation on the surrounding tissue and the body as a whole. 3. Loss of rigidity of the implant magnesium based alloy in the process of biodegradation.


An immobilized means for holding a workpiece, comprising: a fastener configured to engage the rod to clamp the workpiece; pin configured to be positioned and secured to the respective pin engaging the workpiece; pad; and an actuator, said actuator the actuator configured to move the clamp for alternately pulling the pad in contact with the workpiece and the jig rod is disengaged, so that securing means assembly to release the workpiece.


The article discusses the initial history of the emergence and development of preliminary investigation bodies in the territory of Kostroma Province in the pre-revolutionary period of time. The published work reveals the process of the gradual
emergence, development and establishment of the institution of a judicial investigator in the course of the judicial reform of Alexander II. When collecting material, the author used inaccessible literary sources on the history of the investigating authorities in Kostroma Province. In the study of sources and source materials, the author used both the universal – the dialectical-materialistic – method of cognition, and the general scientifi c methods of cognition: deduction, induction, analysis, synthesis, logic. The main fi ndings of the study include: the Russian pre-trial investigation in the territory of modern Kostroma Region has deep traditions rooted in pre-revolutionary Russia. The emergence of the institution of judicial investigators in Kostroma Region was carried out as part of the all-Russian modernisation of the judicial investigative system.


A new methodology for the long-term planning of public electricity distribution networks is presented, The methods developed take into account both the uncertainties related to the growth of loads and the dynamic nature of the problem. The basic methods used are stochastic dynamic programming and statistical decision analysis. By using the proposed approach, the optimal investment strategy for the long-term development of a distribution network can be evaluated. The methods presented are applied to medium-voltage (e.g. 20 kV) networks, which are radially operated.


Advanced Substrates consist of a 200-nm-thick GaN layer bonded to a handler wafer. The thin layer is separated from source material by Smart CutTM technology. GaN on Sapphire Advanced Substrates were used as seeds in HVPE-GaN growth. Unintentionally doped and silicon-doped GaN layers were crystallized. Free-standing HVPE-GaN was characterized by X-ray diffraction, defect selective etching, photo-etching, Hall method, Raman spectroscopy, and secondary ion mass spectrometry. The results were compared to HVPE-GaN grown on standard MOCVD-GaN/sapphire templates.


Information about the structure of the course can be found in the course syllabus, handed out the first day of class and available on the course website at Digital machines dominate our everyday life to such a degree that it is hard to imagine a time when the idea of a programmable computer was but a twinkle in a few oddball's eyes. But that's the way it was, for example, way back in 1936 when Alan Turing wrote his famous paper " On computable numbers, with an application to the Entscheidungsproblem " where the notion of a universal Turing machine was first introduced. In the years that followed, the optimism of the earlier pioneers in computing must have seemed insane: machines which can execute billions of arithmetic operations per second? Crazy! Even after the invention of the transistor, few suspected that digital computers would be as ubiquitous and useful as they are today. The force (or whatever you want to call it, especially if you aren't Luke Skywalker) behind this, of course, is Moore's Law (or Moore's self-fullfilling prophecy if you want to be a cynic, but I prefer not to get so cynical, especially at the beginning of a class): the feature size on silicon chips is cut in half approximately every two years. Since Gordon Moore (whose hand I got to shake...twice!) wrote down his famous prediction forty years ago, we have been in an era of unprecedented growth. But Moore's law is not really a law, but a statement about the rate of technological progress for computers. And if one thinks for a while, one begins to wonder when Moore's law will end (and perhaps, what will happen to your job when this happens!?) If we blindly extrapolate Moore's law into the future we see that somewhere around 2050, the feature size of computers would need to be the size of an atom. The size of an atom! Which makes us wonder (1) whether Moore's law will be able to reach the atomic size? and (2) what happens when we get to machines that are so small? Of course we don't know the answer to either of these questions because foresight isn't 20/20, but we can, as engineers, physicists, chemists, and material scientists make some rough guesses about (1). What we know is that even today we can construct transistors which are molecular sized. Now these aren't …


Several hundred microearthquakes observed with ultra-sensitive tripartite network at Matsushiro are analysed for the purpose of location of their origins. Attentions are drawn to the fact that lower limit of the observed apparent velocities shows a systematic tendency concerning the direction of the wave propagation. It varies broadly from 3.6km/s to over 10km/s. This tendency is interpreted due to the inclination of the surface layer boundary near the observatory. If the lower limit corresponds to the critical case of wave refraction, the expected inclination of the boundary is calculated to be 13 degrees under one of the crustal models proposed by Mikumo et al. (1961). Seventy five percents of analysed shocks are located in the western side of the fossa magna.


Nanozymes have the potential to replace natural enzymes, so they are widely used in energy conversion technologies such as biosensors and signal transduction (converting biological signals of a target into optical, electrical, or metabolic signals). The participation of nucleic acids leads nanozymes to produce richer interface effects and gives energy conversion events more attractive characteristics, creating what are called "functional nanozymes". Since different nanozymes have different internal structures and external morphological characteristics, functional modulation needs to be compatible with these properties, and attention needs to be paid to the influence of nucleic acids on nanozyme activity. In this review, "functional nanozymes" are divided into three categories, (nanozyme precursor ion)/ (nucleic acid) self-assembly, nanozyme-nucleic acid irreversible binding, and nanozyme-nucleic acid reversible binding, and the effects of nucleic acids on modulation principles are summarized. Then, the latest developments of nucleic acid-modulated nanozymes are reviewed in terms of their use in energy conversion technology, and their conversion mechanisms are critically discussed. Finally, we outline the advantages and limitations of "functional nanozymes" and discuss the future development prospects and challenges in this field.


is the premier computer graphics conference. This conference continues to attract many outstanding contributions describing the most recent and exciting developments in computer graphics. The SIGGRAPH program committee felt that a number of these papers should be considered for publication in TOG. This then started a process in which each of these papers was extensively refereed, revised and refereed again (in addition to their being reviewed by three reviewers for the conference). In the end, four were finally selected to be published in TOG: three in the April 1983 issue, one in the July 1983 issue. I must admit that I viewed much of this reviewing process from the sidelines. The process was organized by Dan Bergeron and his associate editors, who all put in a tremendous amount of energy to make this issue possible. The authors pitched in by revising and improving their papers within nearly impossible time constraints. This issue is a credit to the work of all these people.


Abstract : The purpose of this investigation is to evaluate the earthquake hazards at Eisenhower and Snell Locks along the Saint Lawrence Seaway and to provide time histories for earthquake ground motion that represent the cyclic shaking that would be felt in the free field on bedrock at the lock sites. Ground motions defined by this study are for use in the engineering-seismic evaluation of the respective locks. This study consists of both a geological and a seismological analysis and consists of the following (1) a geological evaluation of fault activity at the sites and in the region, (2) a seismological appraisal of the historic seismicity in the region, (3) as interpretation of seismic source areas and maximum earthquakes with their prospects for recurrence, and (4) attenuated peak ground motions at the sites with time histories aor analogous cyclic shaking. The area covered by this study are the sites of the Eisenhower and Snell locks near Massena, New York, portions of New England and Canada and the St. Lawrence Valley which has been a source of major historic earthquakes.


OBJECTIVE: To investigate the effects of different excipients and formula on fluid-bed drying granulating of Xinmaishen capsule and to optimize the granulating formula. METHODS: The effects of different excipients and formula on granules were investigated with degree of granulating difficulty; granule yield; hygroscopicity and critical relative humidity as assessing index, and the formula was optimized as well. RESULTS: The optimized formula of Xinmaishen granule had the volume ratio of 1∶ 0. 3∶ 0. 3∶ 0. 4 for exact∶ lactose∶ dextrin∶ gum acacia and the critical relative humidity was about 50% . CONCLUSION: The granule prepared in this formula ratio had a decreased hygroscopicity, prolonged shelf life as compared with the former formula and an stronger stability.


When any primary amine reacts with an aldehyde or a ketone under specific conditions, Schiff bases are formed. The general structure of Schiff base is R2C∙NR′ and is considered as a subclass of imines which is commonly used as a synonym for azomethine. The first imines were prepared in the nineteenth century by a classical method that involves condensation of a carbonyl compound with the help of amine under the distillation of azeotropic and to remove water formed in the system, molecular sieves are used. Later many ways of synthesis of Schiff bases are invented. Schiff bases exhibit a wide range of biological activities and are commonly used for industrial purposes. These are the most widely used as intermediates in organic synthesis, catalysts, pigments and dyes, polymer stabilizers, etc.


The ability of the macrocyclic hexaaza-dithiophenolate macrocycles (H2LH6, H2LMe2H4, and H2LMe6) to support dinuclear zinc complexes has been examined. The macrocyclces contain two 4-tert-butylthiophenolate units which are connected by two lateral dipropylenetriamine units with different nature and patterns (secondary or tertiary) of the N donors (H2LH6: 6 × R2NH, H2LMe2H4: 4 × R2NH, 2 × R2NMe, H2LMe6: 6 × R2NMe). Three binuclear complexes ([Zn2(LH6)]2+ (1), [Zn2(LMe2H4)]2+ (2), and [Zn2H2(LMe6)Cl2]2+ (3)) were obtained, isolated as ClO4– or BPh4– salts, and characterized by CHN, ESI-MS, IR, and NMR spectroscopy, and X-ray crystallography (1(ClO4)2, 1(BPh4)2, 2(BPh4)2, 3(ClO4)2). In contrast to the parent N6S2 macrocycles with diethylenetriamine linkers which support bioctahedral [Zn2L(L′)]n+ complexes (L' = bridging coligand), the present ligands coordinate to zinc with non-bridging thiolato donors to afford tetrahedral ZnN3S (1,2) or ZnN2SCl (3) coordination environments. The decrease of the coordination number from 6 in the [Zn2L(L′)]n+ to 4 in the present complexes is attributed to the change of the chelate-ring size. The six-membered chelate rings in 1–3 allow larger bond angles and encourage tetrahedral coordination.


PURPOSE: A rolling-element hold spacer for retaining, in a rotatable and slidable manner, rolling elements used in a rectilinearly-movable apparatus, such as a rectilinearly-rolling guide apparatus, a ball screw, and a ball spline, as well as a rectilinearly-movable apparatus using the rolling element hold spacer is provided. CONSTITUTION: A rolling-element hold spacer (9) includes a spherical indent (11) which is formed in either side of a rolling element (7) so as to match the curved surface of the rolling element (7); thick hold sections (10a,10b) to be interposed between the rolling elements (7); and thin bent sections (12) for interconnecting only one thick hold section pair (10a,10b) in which the rolling element (7) is to be interposed. The thin bent section (12) is deflected or twisted in a curved portion of a rolling-element circulation path. Further, the rolling-element hold spacers which are adjacent to each other with a single rolling element interposed therebetween mutually perform pivotal movement around the rolling element (7), thereby enabling smooth circulation of the rolling elements (7). Clearance arises between the rolling element (7) and the thick hold sections (10a,10b) as a result of bent of the thin bent section (12). Lubricant enters the clearance, to thereby sufficiently lubricate the rolling elements (7). So long as a rolling-element hold spacer (9) is placed around every other rolling element (7), all the rolling elements (7) are eventually held by the rolling-element hold spacers (9). Consequently, the number of rolling-element hold spacers (9) can be reduced to one-half the number of the rolling elements (7), and the number of rolling elements (7) can be increased correspondingly.


In the paper we describe structures of quasitriangular Lie bialgebra on gl 2 ( C ) using the classification of Rota-Baxter operators of nonzero weight on gl 2 ( C ) .


The present invention is a display device, and relates to a control method of the power integrated circuit, a controller for generating a switch pulse which is synchronized to the input video, and initialize the switch pulse in the frame blanking period without the input image, and the switching pulse control It is driven according to a signal and a power integrated circuit for generating the power to the display panel. More than 0 and contrast adjustment in the normal period duration duty ratio is set within the frame blanking period of the switching pulse signal is adjusted to within 3%. Accordingly, the present invention can be controlled to the minimum duty ratio change of the switched pulse signal in the frame blanking period to prevent image degradation due to power fluctuations.


There has been a rapid expansion of activity in the field of biomaterials and related medical devices, both in scientific terms and in clinical and commercial applications. The author of this book has been influential in setting the standard for the accurate definition of some of the terms used, and in particular his definition of biocompatibility, agreed at a 1987 conference, has been accepted around the world. The book presents definitions and explanations of 6000 terms used not only in the fields of biomaterials and medical devices, but also in materials science, biological sciences, and clinical medicine and surgery.


Partial measurements in flight of the handling qualities of a Grumman XF7F-1 airplane were investigated. Results are for low altitude and normal center of gravity conditions only.


New fermentation source in the technology of fermented non-alcoholic beverages. Decoding and identifi cation of microbe composition of trivially called rice fungus as a new fermentation source have been studied. It has been found out that Orуzamyces indici РГЦ is an associative consortium of microorganisms of various groups: Zygosaccharomyces fermentati Naganishi, Pichia membranaefaciens Hansen, Lactobacillus paracasei subsp. рaracasei, Leuconostoc mesenteroides subsp. dextranicum, Acetobacter aceti, and it is potentially able to bring about the fermentation processes. Technology of new fermented non-alcoholic beverage "Klukovka" of higher biological value has been developed.


Distance function is a main metrics of measuring the affinity between two data points in machine learning. Extant distance functions often provide unreachable distance values in real applications. This can lead to incorrect measure of the affinity between data points. This paper proposes a reachable distance function for KNN classification. The reachable distance function is not a geometric direct-line distance between two data points. It gives a consideration to the class attribute of a training dataset when measuring the affinity between data points. Concretely speaking, the reachable distance between data points includes their class center distance and real distance. Its shape looks like "Z," and we also call it a Z distance function. In this way, the affinity between data points in the same class is always stronger than that in different classes. Or, the intraclass data points are always closer than those interclass data points. We evaluated the reachable distance with experiments, and demonstrated that the proposed distance function achieved better performance in KNN classification.


Abstract:In this article, one of the key questions I will be asking is whether the publication process of children's literature written in a minority language and the interrelationship between the illustrations and text during this process call into question the notion of a predetermined original, as well as the binary model of the translation process and, ultimately, the fixed nature of language. As a case study, I will analyze a picturebook—Selina Chönz's Uorsin (1945)—that was simultaneously released in two languages (one a major language and the other a minority one) and in multiple dialects (of the minority language). I will also discuss Uorsin's two sequels, Flurina und das Wildvöglein (1952) and Der grosse Schnee (1955)—which were first written in German as accompaniments to the images of the illustrator, Alois Carigiet, and which were only translated into Romansh at a later point in time. I will draw on scholarship in translation studies (Roman Jakobson; André Lefevere), adaptation studies (Linda Hutcheon), children's literature (Maria Nikolajeva and Carole Scott; Benjamin Lefebvre), and children's literature translation studies (Emer O'Sullivan; Riitta Oittinen; Gillian Lathey) and show that the written text and its illustrations are already in conversation during the publishing process. Thus, each can be described as a form of adaptation of the other.


The adults of the new species Zachvatkinibates svanhovdi A. Seniczak and S. Seniczak sp. nov. are described and illustrated from Norway, and this is the first finding of Zachvatkinibates Shaldybina, 1973 in Fennoscandia. This species is the most similar to Z. quadrivertex (Halbert, 1920), but differs from it mainly by the shape of notogastral setae, posterior tectum of notogaster and lack of postanal porose area Ap, which in Z. quadrivertex is present. In Z. svanhovdi, the prodorsal seta in is long, translamella is narrow, notogastral setae are short and distally pliable, notogastral porose areas are usually oval and of medium size, but Aa can be larger, especially in males. Dorsal crest on tarsus I is present. The cytochrome oxidase I (COI) barcodes (length: 658 bp) of five specimens of the new species are provided; the maximum variation within the species was 2.41% (p-dist). The morphology and ecology of the new species is compared with other Zachvatkinibates species. The knowledge on family Punctoribatidae in Fennoscandia is updated, and Mycobates carli (Schweizer, 1922) is first reported from Norway.


Esophageal cancer (EC) is the leading cause of cancer‐related mortality worldwide. The underlying genetic risk factors remain unclear. The association between gene growth hormone receptor (GHR) and phospholipase C epsilon 1 (PLCE1) polymorphisms and the EC risk were identified in this study.


This investigation was carried out to determine the incidence of bacterial respiratory pathogens in cattle. A total 300 samples were collected from the respiratory system of 200 sample of 100 slaughtered cattle, 50 apparently healthy cattle and 50 animals with respiratory affections. Bacteriological examination of these samples from recent slaughter and living cattle resulted in isolation of 150 (65.22%) and 80 (37.78%), respectively. The results showed that 230 animals were positive with an incidence of (76.67%), of which some cases showed mixed infection and few had one bacterial isolate in a pure form in culture. The total numbers of isolates were 214 of which 70 (28.09%). Staphylococcus spp. 90 (42.06%), E. coli, 25 (11.66%) Proteus spp. 15 (7.01%), Pasteurealla spp., 9 (4.21%), Citrobacter spp. and 15 (7%) Pseudomonas spp. Besides, the antibiotic sensitivity test was done in vitro on some pathogenic respiratory bacterial isolates. Most microorganism were sensitive to enerofloxacin. INTRODUCTION Cattle are considered the most important farm animals, cattle are the main source of milk, meat and hides. Cattle are susceptible to many respiratory pathogens, the most serious of them are the bacterial pathogens (Blood and Henderson, 1979). Isolation And Identification Of Bacterial Causative Agents ... Talat Hamed Shesah Badier 385 Many aerobic bacterial agents causes respiratory disorders in cattle. Actinomyces pyooens, P. haemolytica, E. coli, Ps. aeruginosa, Haemophilus and Salmonella were incriminated in the aetiology of respiratory diseases in cattle (Fischer, 1975, Garoiu et al., 1982, Sing and Singh, 1980 and Barboura, 1997). Indole-negative pasteurllae, producing dermonecrotic pasteurella toxin were isolated from the nose of calves in a herd with enzootic bronchopneumonia Ehlers et al. (1993). On the other hand, virtalal et al. (1996) suggested that a synergistic effect between mycoplasma species and P. multtiocida which were isolated from respiratory samples of cattle. P. muttocida and P. haemolytica were covered from pneumonia lungs of stressed feeder calves than died from bovine respiratory tract disease, (Putdy et al., 1997). Six strains of Corynebacterium spp. were isolated from 137 slaughtered cattle with an incidence of 4.5% El-Enbaw (1986). Examination of 33 diseased cattle lungs were done by Collins et al. (1988) and the infection was attributed to Pasteurella species, mycoplasma and S. aureus. This study was done to show the predominant respiratory bacteria among cattle. MATERIALS AND METHODS A total of 300 samples were collected from respiratory system of cattle (200 samples were from 100 slaughtered cattle, 50 of apparently healthy cattle and 50 from diseased ones). Samples were collected from cattle were nasal swabs, tracheal swabs, laryngeo tracheal swabs and Isolation And Identification Of Bacterial Causative Agents ... Talat Hamed Shesah Badier 386 heart blood. The samples collected by sterile cotton swabs. From freshly slaughtered cattle and immediately transferred to the laboratory for cultivation. Lung samples were collected from congested lung areas of the slaughtered cattle, in sterile plastic bags and transported on ice box for bacteriological examination. Collected samples were inoculated onto enrichment media (peptone water, nutrient media and loffers media), then inoculated onto nutrient agar, blood agar, mannitol sal agar and MacConkey agar plates and incubated aerobically at 37 o C for 24-48 hours. Suspected growing colonies were characterized on the basis of morphological and colonial appearance according Finegold and Martin, (1982). The pure colonies were identified biocemcially according to Koneman et al. (1983) and Kries and Holt (1989). The pathogenicicity and virulence of some isolated strains P. multocida to mice were determined according to Wilson and Miles (1975). Susceptibility of the most predominant pathogenic isolates to different chemotherapeutic agents was tested the disc diffusion method according to Finegodl and Matin (1982). RESULTS Table (1) results revealed that the bacterial isolates were 150 (65.22% and 80 (34.78%) in recent slaughtered and living cattle animals respectively. Table (2) illustrated that the number and incidence of bacterial isolates in 100 tracheal swabs and 100 lung tissues was 80 (53.33%) and 70 (46.67%), respectively. While Table (3) revealed that number and incidence of bacterial positive samples in apparently and diseased cattle were 0 (44.44%) and 50 (55.56%). Isolation And Identification Of Bacterial Causative Agents ... Talat Hamed Shesah Badier 387 Table (1): Rate of bacterial isolation from respiratory system of cattle. Positive Negative Source and types of samples No. of samples No % No % Slaughtered Cattle (different parts of resp. systems) 200 150 75 50 25 Living cattle (nasal swabs) 100 70 70 30 28.57 Total 300 230 76.67 70 23.33 Table (2): Types of infection and incidence of bacteriological positive cases in slaughtered cattle. Positive Negative Source and types of samples Total no. of samples No % No % Trachea swabs 100 80 53.33 20 40 Lung tissues 100 70 46.67 30 60 Total 200 150 75 50 25 N.B. No. of isolates ( %). Table (3): Results of bacteriological examination of living cattle. Positive Negative Source and types of samples Total no. of samples No % No % Apparently healthy cattle 50 40 44.44 10 100 Diseased cattle 50 50 55.56 0 0 Total 100 90 90 10 100 Table (4) revealed the presence of E. coli 90 (42.06%) and Staph. aureus 60 (28.04%) and Citrobacter 9 (4.21%). Table (5) illustrate that bacterial isolates in slaughtered cattle were 175 (58.41%) and in living animals were 89 (41.59). Isolation And Identification Of Bacterial Causative Agents ... Talat Hamed Shesah Badier 388 Table (4): The incidence and occurrence of pathogenic and potentially pathogenic bacteria in samples from examined cattle. Living cattle (100) Total Slaughtered (200) Healthy cattle (50) Diseased ones (50) Bacterial species No. % No. % No. % No. of isolates Isolation rate % S. aureus 50 40 0 0 0 15.6 60 28.04 P. multocida 5 4 1 4 5 7.81 11 5.14 P. haemolytica 3 2.4 1 4 0 0 4 1.87 Ps. aeruginosa 0 0 0 0 15 23.44 15 7.00 E. coli 50 40 15 60 25 39.06 90 42.06 Proteus 15 12 5 20 5 7.81 25 11.68 Citrobacter 2 1.6 3 12 4 6.25 09 4.21 Total 125 100 25 100 64 100 214 100 Table (5): The total bacterial groups in examined cattle. Slaughtered cattle (200) Living ones (100) Total (300) Bacterial group No. % No. % No. % Staph. aureus* 50 40 10 11.23 60 28.03 Pasterulla spp.** 8 6.20 7 7.89 15 7.50 Ps. aureuginos** 0 0 15 16.85 15 7.50 E. coli** 50 40 40 44.90 90 42.05 Proteus** 15 12 10 11.23 25 20.56 Citrobacter** 2 1.52 7 7.84 9 4.20 Total 125 58.41 89 41.59 214 100 * Gram positive group. ** Gram negative group. Isolation And Identification Of Bacterial Causative Agents ... Talat Hamed Shesah Badier 389 Table (6): Results of antibiotic sensitivity test to some pathogenic representative bacterial strains (8 isolates of each type m.o.). 1 2 3 4 5 6 7 Antibiotic disc R S R S R S R S R S R S R S Ampicillin 5 3 8 0 8 0 4 4 8 0 8 0 0 0 Tetracycline 8 3 5 8 0 4 4 8 0 8 0 0 0 Gentamycine 8 0 5 3 8 0 8 0 8 0 8 0 0 0 Streptomycine 3 5 4 4 8 0 8 0 8 0 8 0 0 0 Erythromycine 4 4 6 2 8 0 8 0 8 0 8 0 0 0 Enerofloxacin 0 8 0 8 0 8 0 8 0 8 0 8 0 8 R = Resistance M = Moderate S = Sensitive 1= Staph. aureus 2 = Pasteuriella spp. 3 = Ps. eruginosa 5 = E. coli 6 = Proteus spp. 7 = Citrobacter spp. DISCUSSION The results emphasize the role of bacterial pathogens as a complicating cause in respiratory diseases in cattle. The results agreed with the obtained ones by Palatary and Newhall (1985). Examination of 300 samples (Lung and Nasal swabs) from affected cattle revealed that 76.67% of them were harboured pathogenic bacteria such high incidence of isolation was also reported by Zaid (1996). The obtained results revealed that Staph. aureus isolated percentage 28.09% were agreed with the results obtained by Abo-Aikhail and ElNaenaeey (2003). While E. coli isolates percentage (42.06%) was higher than obtained by Abo-Aikhail and El-Naenaeey (2006) due to these cattle reared and sever stress and less nutrition some of strains of Pasteuriella species were resistant and some other ones were sensitive to ampicillin, tetracycline, gentamycine, strepomycine and erythromycine, these results are like to results obtained by Ungureanu et al. (1988). Isolation And Identification Of Bacterial Causative Agents ... Talat Hamed Shesah Badier 390 Pasteurella species incidence (7.01%) in this study was high to obtained by Al-Human et al. (2004) due to sever stress factors affected on the cattle in our study. The incidence of other obtained bacterial agents were 7.5% (Ps. aureuginosa), 2.56% (Proteus species) and 4.20% (Citrobacter species), which nearly agreement with the other one obtained by Abo-Aikhail and El-Naenaeey (2003). This study results were revealed that most of the examined strains were all resistant to Ampicilline tetracycline, genamycine, streptomycine and Erythromycine which agreed with Abo-Aikhail and El-Naenaeey (2003) and more sensitive to enerofloxacine. REFERENCES Abo-Aikhail, A. El-M. and El-Naenaeey, E.Y. (2003). Studies on terobic bacteria causing respiratory infections in cattle with special reference to zoonotic importance. Suez Canal. Vet. Med. J., VI (2). Al-Humam, N.A.; Al-Dughaym, A.M.; Mohammed, G.E.; Housam, E.M.; Gameel, A.A. (2004). Study on the isolation and pathogenicity of pasteurella multocida type A. in calves in Saudi Arabia. Pakistan J. of Biological Sciences 7(4): 460-463. Barbour, E.K.; Nabbutt, N.H.; Hamadeh, S.K. and Al-Nakhli, H.M. (1997). Bacterial identity and characteristics in health and unhealthy respiratory tracts of sheep and calves Vet. Res. Commun, 21(6), 421430. Isolation And Identification Of Bacterial Causative Agents ... Talat Hamed Shesah Badier 391 Blood, D.C. and Henderson, J.A. (1974). Veterinary Medicine 9 Edition. The English Language book


Abstract Background Anti-SARS-CoV-2 serological responses may have a vital role in controlling the spread of the disease. However, the comparative performance of automated serological assays has not been determined in susceptible patients with significant co-morbidities. Methods In this study, we used a large number of COVID-19 negative patient samples (n = 2030) as well as COVID-19 positive patient samples (n = 112) to compare the performance of four serological assay platforms; Siemens Healthineers Atellica IM Analyzer, Siemens Healthineers Dimension EXL Systems, Abbott ARCHITECT, and Roche cobas. Results All four serology assay platforms exhibited comparable negative percent agreement with negative COVID-19 status ranging from 99.2-99.7%, and positive percent agreement from 84.8-87.5% with positive real-time reverse transcriptase polymerase chain reaction (RT-PCR) results. Of the 2142 total samples, only 38 samples (1.8%) yielded discordant results on one or more platforms. However, only 1.1% (23/2030) of COVID-19 negative cohort results was discordant whereas discordance was 10-fold higher for the COVID-19 positive cohort at 11.3% (15/112). Of the total 38 discordant results, 34 were discordant on only one platform. Conclusion Serology assay performance was comparable across the four platforms assessed in a large population of COVID-19 negative patients with relevant comorbidities. The pattern of discordance shows that samples were discordant on a single assay platform, and discordance rate was 10-fold higher in the COVID-19 positive population. Impact statement High negative percent agreement reinforces the reliability of serology testing especially in a cohort of at-risk patients. Serology platform discordance highlights the importance of a two-test strategy for properly identifying seroconverted patients.


Objective To investigate the expression of insulin-like growth factor-1(IGF-1) and its receptor(IGF-1R) in the patients with leiomyoma and their roles in the pathogenesis.Methods ELISA was used to determine the expression of IGF-1 and IGF-1R in 23 patients' leiomyoma,myometrium and sera.Each patient served as self-control.EIA was used to determine the levels of estradiol(E2) and progesterone(P) in their sera.Another 30 healthy women were enrolled in as normal serum controls.Results(1) The expression of IGF-1 and IGF-1R was stronger in leiomyoma than in myometrium(P0.01).(2) There was no difference in the expression of IGF-1 in the serum between the patients and the normal subjects(P0.05).The expression of IGF-1R was stronger in the patients than in the normal subjects(P0.01).(3) There was no significant difference in serum E2 and P at proliferation and secretion phases(P0.05).Conclusion Overdue expression of IGF-1 and IGF-1R is a probable mechanism in the development of uterine leiomyoma.Estrogen and progestogen mediate the effect of IGF-1 on leiomyoma.IGF-1 acts on the growth and proliferation of leiomyoma mainly through autocrine or paracrine.It is a probable regulatory factor in the growth of leiomyom.


Girth limit felling and bark beetle attack All stands of norway spruce older than 60 years within the forest range "Kamschlacken" in the Harz mountains have been examined for infestations of living trees by the spruce bark beetle ( Ips typographus ) in autumn 1998. These stands were classified into three different types of forestry utilization applied in 1997 and 1998: 1. girth limit felling (ZN in the german text and tables), 2. thinning (NN) and 3. no utilization except sanitary felling (KN). Along 60 surveystrips running with the gradient of the slopes and forming straight lines in a distance of 100 m to each other, 183 pieces of tops resp. short Logs remaining after utilization of the main stern were measured and exarnined for bark beetle infestations. The diameters of these tops/logs were between ll and 41 cm and - within this range - did not show a significant influence on the density of mother galleries and the reproduction rate. Both parameters neither were correlated with the degree of canopy cover directly over the respective log or top. But the chi-square-test revealed a highly significant influence of the type of utilization on the deadly typographus -infestation in neighbouring living spruce: Stands with girt limit felling exhibited twice as many infestation spots (> 2 infested trees) and three tirnes more single infested trees than to be expected according to the relations between the hectarages of the three utilization types ZN, NN and KN. In this context, the clear dependence of the number of infested standing trees within a given stand on the total of reproductive mother galleries in tops and logs in that stand was not very surprising. Even though the data base needs enlargement by additional investigations in other districts, already this result gives an alarming indication of the bark beetle infestation risk connected with the new utilization-type of girth limit felling with thick tops remain ing as breeding material in the stand.


A successful air-based remediation system, now frequently chosen for sites contaminated with VOCs, demands a thorough understanding of the nature and distribution of the VOCs and the soil air permeabilities. Considering likely remediation methods during the site investigation allows collection of all data needed for method selection and design within a single, highly efficient site visit. A case history illustrates how to integrate several data collection and testing activities into a single site visit.


The purpose of this presentation is to have the participants of the tutorial understand common patterns of project management mistakes. Such mistakes directly cause late, over budget, poor quality software to be produced. Participants will then learn a new approach to developing software which keeps their teams on target. As long as the team operates under the new paradigm, the team is very productive and stays in "the software development zone."The zone approach addresses risk in all activities of software development, Risk management done in this manner is one of three critical success factors that serves to keep your software staff "in the zone." The two other factors will be discussed in the presentation. After understanding all three of the critical zone factors, participants of the presentation will have an opportunity to practice zone management on a sample requirements specification.


Relatively Myasthenia gravis is an uncommon disorder with an annual incidence of 10-20 new cases per million. Diagnosis follows a bimodal distribution with a predominantly female peak in the second and third decade of life and a predominantly male peak in the fourth to eighth decades. It presents with fluctuating skeletal muscle weakness and fatigue most commonly affecting the ocular muscles, although any muscle may be affected. MG affects 50 to 200 per million people. It is newly diagnosed in three to 30 per million people each year. Diagnosis is becoming more common due to increased awareness. Although there is still no cure for myasthenia gravis in modern sciences other than symptomatic management, Ayurvedic therapies can give much more promising results. Comparison between myasthenia gravis and diseases explained in Ayurveda is difficult and exact correlation is not possible. But based on Nidana, Roopa, Upashaya , and Anupashaya , a probable diagnosis can be made and treated accordingly. When aggravated, a single Dosha may cause manifold diseases depending upon the various etiological factors and the sites of manifestations. Hence nomenclature of all types of diseases in definite terms is not always possible. If a physician is not able to name a particular disease, he should not feel ashamed on that account. In the present study, Vatavyadhi chikitsa, Asthimajjagata vata chikitsa, Arditavat chikitsa and Avarana concepts were applied for diagnosis and treatment. Nasya, Nasapana, Basti chikitsa were planned accordingly. Vatakaphahara, Dhatvagni vardhana, Brimhana and Snehana dravyas were used in the management.


To improve hierarchical the disposable position and reliability of the simulation results of the remaining oil for accurate simulation of water flooding history,combined with the oilfield layered water injection data to analyze the characteristics of the faucets mouth loss,set up to consider starting differential pressure,water nozzle diameter and loss characteristics of the mouthstratified water injection numerical simulation model,layers paragraphs front of the mouth of the stratified injection wells flow pressure the mouth loss equation well-grid pressure equation coupled;consider layered the waterflood reservoir simulation linear system generates wellbore flow well-reservoir flow coupling stratified water injection reservoir simulation and stratified water injection analog functions in PBRS(parallel black oil simulator).The simulation results show that the model can reflect the role and development of mining stratified water injection effect,to alleviate the oilfield layer utilized contradiction between to improve waterflooding development effects.


Magnetism
Quantum spin liquids avoid conventional magnetic ordering down to the lowest temperatures. Among the candidates for this state of matter, organic salts such as κ-(BEDT-TTF)2Cu2(CN)3 have been prominent. Miksch et al. studied this material using electron spin resonance to elucidate the nature of its ground state. Instead of the expected gapless state, the temperature dependence of spin susceptibility suggests the formation of a spin gap.

Science , this issue p. [276][1]

 [1]: /lookup/doi/10.1126/science.abc6363


You may download books from anvatquynhon.xyz. Project is a high quality resource for free e-books books.Give books away. Get books you want. No annoying ads enjoy it and don't forget to bookmark and share the love!Look here for bestsellers, favorite classics and more.The anvatquynhon.xyz is home to thousands of free audiobooks, including classics and out-of-print books. Search for the book pdf you needed in any search engine.


This volume is a translation of the 1977 German edition, and the additional time required to produce an English version has dated some of the contents. Nevertheless, there is sufficient careful and original analysis in this volume to give it lasting value. The book can be divided into three parts. The first part, consisting of chapters 1-6, deals with the motivation for and forms of industrial cooperation between Western firms and the enterprises and state organs of the Communist countries of Eastern Europe. The authors present a useful typology of cooperation with insights into the strengths and weaknesses of each form of cooperation. The chapters on motivation and institutions are less satisfactory for two reasons. First, the authors fail to connect the broad trends (such as growing industrial concentration and specialization) that they identify as the ultimate causes of cooperation to changes in the microlevel environment which impel firms to seek East-West cooperation. Second, in their analysis of both motivations and institutions, the authors' emphasis is overwhelmingly on the East. Western institutions and, more importantly, the motivations of (and alternatives available to) Western firms receive only a cursory treatment. The second section of the book, chapters 7-9, examines the broader context of industrial cooperation. Though dated by recent events, chapter 7 is a very good discussion of the negotiations toward a trade agreement between the European Economic Community and the Council of Mutual Economic Assistance or its member countries. Chapters 7 and 8 discuss the effects of intergovernmental cooperation agreements and of the business cycle on cooperation. The last section of the book consists of three chapters which evaluate experiences with industrial cooperation. These are supplemented by appendixes, the most important of which present eleven case studies of industrial cooperation and a list of industrial cooperation agreements. Unfortunately, the case studies are so brief that they provide little insight into the problems and potential benefits of industrial cooperation. Industrial cooperation is a difficult subject to analyze, primarily because definitions are amorphous and the raw data consist of either aggregate data of dubious veracity or the experiences of individual firms, which must then be made comparable to the experiences of other firms. The authors have done well to extend their study as far as they have, and their conclusions and insights should serve as a basis for further data gathering and deeper analysis.


The small size and small refrigeration requirements of superconducting sensors make these devices a poor match to conventional cryogenic refrigeration systems. We have considered the design and construction problems of building microminiature refrigerators for the cooling of these devices which would match their cooling requirements. Preliminary work is described on the construction of a first stage 77 K refrigerator built on a Si‐wafer using photolithography.


A search for an optimal value of a complex multi-dimensional continuous function is still one of the most pressing problems. The genetic algorithms (GA) and evolution strategies (ES) are methods to solving optimization problems that is based on natural selection, the process that drives biological evolution. Our goal was to use evolutionary optimization methods to find the global optimal value (minimum) of a non-smooth multi-dimensional function with a large number of local minimums. We took several test functions of different levels of complexity and used evolution strategies to solve the problem. The standard evolution strategies, which work well with smooth functions, gave us various points of local minimums as a solution, without finding the global minimum, for the complex function. In our work, we propose a new approach: the cross-selection method, which, in combination with previously developed methods - adaptive evolution strategies, gave a good result for the searth for the global minimum the complex function.


Media authentication and tampering localization are important in content delivery via untrusted intermediaries, such as peer-to-peer (P2P) file sharing. Many differently encoded versions of a media file might exist. Our previous work applied distributed source coding to authenticate the legitimate diversity of encoded images and also localize the tampered regions in an inauthentic image. The authentication/localization decoder was supplied with a Slepian-Wolf encoded image projection as authentication data. We extend our scheme to localize tampering in contrast and brightness adjusted images using an expectation maximization algorithm at the decoder. Experimental results demonstrate that tampered image blocks can be identified with high probability using data of only a few hundred bytes for a 512 times 512 image.


The P fixation capacity of the four major soil groups of Tamil Nadu was estima- tod. The P fixation capacity of the soils ranged from 20 to 183 mg P/100 g of soil with a mean value of 85 mg P/100 g of soil. The soils studied were found to differ widely in their P fixation capacity, the highest value of P fixation capacity was recorded in the high level latorita soils of Ootacamund and the lowest in the alluvial soil of Melalathur. The P fixation capacity was found to be positively correlated with clay (r=0.632), total R30, (r=0.483). Also, (r=0.533). The relationships of P fixa- tion capacity with clay, total R₂Os. Fejos, free Fes0, and organic carbon were more close in acid soils than neutral and alkaline soils. In alkaline soils, the influence of free CaCO was more, whereas in the neutral soils. Fo,O,. CEC and exchangeable Ca influenced the P fixation capacity of soils.


The experimental set-up of a disc brake system are established. The LuGre friction model is adopted to determine the friction force between the disc and the pad. The nonlinear dynamic behavior of the brake pad with non-internal condition is discussed, also the shrill frictional noise signals are investigated. The study shows that with the decrease of disc velocity, the tangential motion of the pad loses its stability, then the pure slip and incomplete stick-slip self-excited vibrations are resulted. The low and high frequency squeal noise are obtained experimentally at the same time. With proper parameters, a chaos phenomenon also can be observed in the tangential motion by the numerical simulation, the experimental test findings are used to verify the numerical simulation results.


Hydrological process in arid zones differs substantially from that in better documented humid environments. The ponding point for infiltration is reached within 10 mins of first rain and overland flow forms the major component of basin runoff. Drainage densities are high, approaching 100 km.km−2, maximising the opportunity for both water and eroded soil to reach the channel network. The typical flood bore is not as abrupt as the mythology of desert streams would suggest. Nevertheless, the time of rise of the flood hydrograph is usually between 4 and 16 mins, giving credance to the notion of 'flash flood'. Measured flows remain subcritical in the main, though Froude number exceeds unity for short periods around peak discharge. Flow is exceedingly turbulent, with Reynolds number > 105 even for much of the recession limb. As a result, suspended sediment concentrations by size grade are shown to be hydraulically controlled. However, the high degree of turbulence and wide availability of sediment from hillslope and channel sources also means that the mean size of the suspended load varies systematically with flow parameters. In this respect, ephemeral streams differ from perennial counterparts in humid environments where no clear-cut relationships exist. There is greater prospect of deriving a physically deterministic model of suspended sediment transport in desert streams. Implications for soil erosion and reservoir siltation are discussed, and sediment is traced from its source to its various sinks within the drainage basin.


We investigate device-to-device (D2D) communication underlaying cellular networks with M-antenna base stations. We consider both beamforming (BF) and interference cancellation (IC) strategies under quantized channel state information (CSI), as well as, perfect CSI. We derive tight closed-form approximations of the ergodic achievable rate which hold for arbitrary transmit power, location of users and number of antennas. Based on these approximations, we derive insightful asymptotic expressions for three special cases namely high signal-to-noise (SNR), weak interference, and large M. In particular, we show that in the high SNR regime a ceiling effect exists which depends on the received signal-to-interference ratio and the number of antennas. Moreover, the achievable rate scales logarithmically with M. The ergodic achievable rate is shown to scale logarithmically with SNR and the antenna number in the weak interference case. When the BS is equipped with large number of antennas, we find that the ergodic achievable rate under quantized CSI reaches a saturated value, whilst it scales as log2M under perfect CSI.


In many astrophysical problems, it is important to understand the behavior of functions that come from rotating (Kerr) black hole orbits. It can be particularly useful to work with the frequency domain representation of those functions, in order to bring out their harmonic dependence upon the fundamental orbital frequencies of Kerr black holes. Although, as has recently been shown by W. Schmidt, such a frequency domain representation must exist, the coupled nature of a black hole orbit's $r$ and $\theta$ motions makes it difficult to construct such a representation in practice. Combining Schmidt's description with a clever choice of timelike coordinate suggested by Y. Mino, we have developed a simple procedure that sidesteps this difficulty. One first Fourier expands all quantities using Mino's time coordinate $\lambda$. In particular, the observer's time $t$ is decomposed with $\lambda$. The frequency domain description is then built from the $\lambda$-Fourier expansion and the expansion of $t$. We have found this procedure to be quite simple to implement, and to be applicable to a wide class of functionals. We test the procedure using a simple test function, and then apply it in a particularly interesting case, the Weyl curvature scalar $\psi_4$ used in black hole perturbation theory.


Giant clams are marine bivalves that inhabit Indo-Pacific coral reefs. The boring giant clam, Tridacna crocea, exhibits bright and conspicuous mantle coloration based on the specialized cells (iridocytes) that generate structural colors. In order to illustrate the coloring mechanism of individual iridocytes, the reflection spectra curve of iridocytes was obtained by a micro-hyperspectral imager. TEM images were obtained to show the inner nanostructures of iridocytes. FDTD simulation was conducted to analyze the relationship between the color of iridocytes and the unique lamellar structure. We found that the laminae in the regular arrangement within cells govern the coloration of individual iridocytes. With the gradual increase of lamellar thickness and spacing, the color of the structure varies from bright violet to orange-red, forming a full visible spectrum. This study provides a new understanding of the various colors produced by individual iridocytes.


Key results of recent studies on cadmium sulfide nanoparticles are systematized. The dependence of the structure and properties of CdS nanoparticles on the nanoparticle size is illustrated. The possibility of utilizing CdS quantum dots as biological labels and sensitizers for solar cells is analyzed. The principles, features and potential of the method of aqueous solution deposition are described from the standpoint of synthesis of CdS nanocrystals and hybrid forms based on them with specified structure and properties. The bibliography includes 180 references.


BACKGROUND
Citrus limon is a small evergreen plant belongs to family Rutaceae. Species are extensively cultivated throughout the world because of their multiple health benefits for humans and their applications in pharmaceutical and food industries. Various studies were conducted using its plant parts(fruits, flowers, peels, leaves, blossoms)but the studies on peel extracts are very limited. However,the anti convulsant activity of peels has not been studied yet.

OBJECTIVE
The main goal of this study is to appraise the anti convulsant effect striked by antioxidant property of Hydroalco-holicextracts of Citrus limon (HAECL) peels in various animal models.

METHODS
The anticonvulsant and in-vivo antioxidant activity of HAECL peels was carried outby Maximal electric shock(MES)model, pentylenetetrazole (PTZ)induced clonic convulsion model and PTZ induced kindling test. The extract was administered to test groups at doses of 200,400 and 600 mg/kg., orallyin PTZ and MES methods. The highest dose of ex-tract was given to the test grouped animals in case of kindling test. After completion of the time period of kindling the brains of all grouped animals were isolated and subjected to analyseoxidative stress parameters such asmalondehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and glutathione (GSH) biochemically to investigate the antioxidant profile of the plant.

RESULTS
HAECL peels at doses of 400 and 600 mg/kg significantly (p<0.01) delayed the onset, decreased the duration of myoclonic spasmin PTZ induced seizure model and also significantly (p<0.01) decreased the duration of hind limb tonic extension (HLTE) as well as significantly (p<0.05)increased the postictalde pression (PID) in MES model compared to control.In PTZ-induced kindling model,the malondialdehyde (MDA)level was elevated in preference with diminished level of SOD, CAT, GSH compared to control group but pre treatment with HAECL at highest dose reduced the MDAlevelandre-finedSOD, CAT and GSH status effectively.

CONCLUSION
From the above inquisition,it was concluded that HAECL is able to produce effective anti convulsant activity and also attenuate oxidative stress inducedduring seizure.


Objectives  Mutations in the genes encoding the transcription factors PROP1 and POUF‐1 (Pit‐1) have been reported as common causes of combined pituitary hormone deficiency (CPHD), and HESX1 mutations have been identified in children with septo‐optic dysplasia (SOD). There are few data on UK children. We have performed mutation analysis in a large cohort of affected children within the West Midlands region to assess the feasibility of a screening strategy for molecular diagnosis in CPHD and SOD.


BACKGROUND
Patients with non-small cell lung cancer (NSCLC) and stable disease (SD) have an unmet clinical need to help guide early treatment adjustments.

OBJECTIVE
To evaluate the potential of tumor biomarkers to inform on survival outcomes in NSCLC SD patients.

METHODS
This post hoc analysis included 480 patients from the IMpower150 study with metastatic NSCLC, treated with chemotherapy, atezolizumab and bevacizumab combinations, who had SD at first CT scan (post-treatment initiation). Patients were stratified into high- and low-risk groups (overall survival [OS] and progression-free survival [PFS] outcomes) based on serum tumor biomarker levels.

RESULTS
The CYFRA 21-1 and CA 125 biomarker combination predicted OS and PFS in patients with SD. Risk of death was ~4-fold higher for the biomarker-stratified high-risk versus low-risk SD patients (hazard ratio [HR] 3.80; 95% confidence interval [CI] 3.02-4.78; p < 0.0001). OS in patients with the low- and high-risk SD was comparable to that in patients with the CT-defined partial response (PR; HR 1.10; 95% CI 0.898-1.34) and progressive disease (PD) (HR 1.05; 95% CI 0.621-1.77), respectively. The findings were similar with PFS, and consistent across treatment arms.

CONCLUSIONS
Biomarker testing shows potential for providing prognostic information to help direct treatment in NSCLC patients with SD. Prospective clinical studies are warranted.

CLINICALTRIALS
gov: NCT02366143.


Los Alamos National Laboratory (LANL) is preparing to implement engineering controls in Sandia Canyon at Technical Area (TA) 72. Los Alamos National Security (LANS) biologists conducted a floodplain determination and this project is located within a 100-year floodplain. The proposed project is to rehabilitate the degraded channel in lower Sandia Canyon where it crosses through the outdoor firing range at TA-72 to limit the loss of sediment and dissipate floodwater leaving LANL property (Figure 1). The proposed construction of these engineered controls is part of the New Mexico Environment Department's (NMED) approved LANL Individual Storm Water Permit. The purpose of this project is to install storm water controls at Sandia Watershed Site Monitoring Area 6 (S-SMA-6). Storm water controls will be designed and installed to meet the requirements of NPDES Permit No. NM0030759, commonly referred to as the LANL Individual Storm Water Permit (IP). The storm water control measures address storm water mitigation for the area within the boundary of Area of Concern (AOC) 72-001. This action meets the requirements of the IP for S-SMA-6 for storm water controls by a combination of: preventing exposure of upstream storm water and storm water generated within the channel to the AOC andmore » totally retaining storm water falling outside the channel but within the AOC.« less


Purpose

Use of cloud-based enterprise resource planning (ERP) services equips an SME to forego the requirements of high financial budget, IT infrastructure, and trained IT personnel as it is required for on-premise ERP solution. The purpose of this paper is to analyze the organizational and technological factors as well as the factors that concern the performance of cloud service provider. These concerns are known as extrinsic factors and they are compliance, network, and information security. This study links the organizational and technological factors of SMEs and the extrinsic factors of cloud vendor for the successful implementation of cloud ERP.

Design/methodology/approach

Resource dependence theory (RDT) was used to understand the relationship of SMEs and cloud service provider. Structural equation modeling was employed in analyzing the data of 208 SMEs that were collected through a survey.

Findings

The empirical analysis supports the RDT as the critical success factors of the SMEs have a positive relationship with the extrinsic factors (compliance, network, and information security) during the cloud ERP implementation.

Research limitations/implications

The data collected in this study is from India and this acts as a limitation as the result might not hold true for other countries and regions. Also, the data collected are cross-sectional and only represent the perspective of the respondents at the time of filling the questionnaire.

Originality/value

This paper attempts to bring out a relationship between SMEs and cloud service provider for the successful implementation of cloud ERP.


The demand for medical schools to produce competent doctors to meet health needs in South Africa has increased. In response to this challenge, the Faculty of Health Sciences at a relatively elite university introduced a problem-based, socially relevant curriculum in 2002. The classroom environment is designed to facilitate a learning context where students from diverse backgrounds engage critically and learn from each other. This study draws on data from a larger qualitative case study to describe how a group of 'black' students who failed their first semester experienced the school–university transition. Drawing on post-structuralist theory, this article analyses how the students negotiated learning and identity. The argument is made that the students re-positioned themselves in deficit, outsider subject positions in order to survive their first year. This article ends with a consideration of the implications for developing a learning environment which recognises difference and fosters diversity.