The entitled session "We express our emotions and learn to control them" it was developed in the area of Social Personnel taking into account the competence: Builds their identity, as well as the ability: self-regulates their emotions and it has been gotten to achieve in the students the performance: Self-regulate their emotions in interaction with their partners, with teacher support, when applying basic self-regulation (breathing) strategies.
During the developed session were applied motivational and challenging activities that encouraged the achievement and active participation through dialogue with the purpose that students express what they feel and think.
It was taken into account the pedagogical processes such as motivation and exploration of previous knowledge, problematization, learning construction and information processing, evaluation and transfer in the didactic processes of the area.
The learning strategies were agreed with the interests and needs of first grade students in primary education.


Every academic year, at the beginning of the course, all the universities in Spain hold a series of events that are part of what we can call the Science Festival, using a 19th century positivist language. Within this celebration, the inaugural lesson, which is delivered by a teacher chosen for this purpose, and who is usually an academic of prestige in his academic specialty, acquires special significance. In a patient manner we have first formed a database of 2165 units, speeches or  opening lessons delivered at the 87 Spanish universities, public and private, from 1939 to 2019. Later we have been able to form several categories of analysis, which host different thematic fields of university life. One of these categories is the "History of Universities", which allows us to obtain a quota of 54 units or inaugural lessons dealing with this topic. From his reading and study we obtain very significant conclusions for the particular history of some universities, especially those considered as classics, but also for the whole of the Spanish university, from its origins in the Middle Ages to the 21st century. It is shown as well as the history of the universities, through a documentary source such as the opening lessons, can be consolidated as a field within the studies on higher education, and also on the institutional history.


In this paper, we first introduce the concept of cognitive machine-to-machine (M2M) communications. In cognitive M2M communications, devices generate packets and the packets are transferred to a concentrator. The concentrators are considered to be secondary users in the cognitive radio network opportunistically accessing a channel allocated to primary users. Based on a random access channel (RACH) mechanism, a queuing model to analyze the performance of cognitive M2M communications is proposed. The queuing model uses an iterative approach to reduce the complexity, and it is able to obtain various performance measures (e.g., queue throughput and delay).


The thinking orientation of dualistic antinomy between utilitarian values and virtue values of the virtueutilitarianism is also hurting people's hardworkedspirits as yet. For this sake, we should transcend the thinking orientation of virtueutilitarianism, and format the time hardworkedspirits basing on the value pursuing and centering round the vocational obligations. 


As game-based learning continues to draw attention, students' perceptions toward classroom activities are vital in influencing the quality of learning. This study used the social cognitive theory to show the perception traits of learning and playing in game-based environments and for students to identify their self-efficacy toward game-based learning by different trait groups. The game Formosa Hope was used in an experiment with 362 fifth- and sixth-grade students at ages 11 to 12 years as participants. Three perception traits were identified through a two-step cluster analysis: I—strong perceptions of learning and playing, II—moderate perceptions of learning and playing, and III—strong perception of playing but weak perception of learning. This study showed that regardless of trait type, students demonstrated positive self-efficacy, with those with Trait I having significantly higher self-efficacy than those with Traits II and III, indicating that students' positive perceptions of learning and playing are essential in prompting self-efficacy in game-based learning.


A method has been developed for measurement of proton conductivity of hydrogen-reducible ionic conductors under protonic fuel cell conditions in which the reducible electrolyte is sandwiched between layers of a nonreducible proton-conducting electrolyte in a disk. The proton conductivity of LiNaSO 4 under the fuel-cell condition was determined with Y-doped BaCeO 3 (BCY) as the nonreducible sandwich layers, using conventional methods under hydrogen at high temperature, under which conditions LiNaSO 4 would otherwise be chemically unstable. LiNaSO 4 and BCY had good chemical and mechanical compatibility in the sandwich disk. The major portion of the ionic conductivity of LiNaSO 4 at 600-680°C is due to Li + and Na + ion transport, and proton conductivity (7.01 X 10 -3 S cm -1 at 600°C to 1.23 X 10 -2 S cm -1 at 680°C) accounts for only 5-10% of total ion conductivity (1.25 X 10 -1 S cm -1 at 600°C to 1.35 X 10 -1 S cm -1 at 680°C). These data explain the poor performance of hydrocarbon conversion fuel cells using LiNaSO 4 as the electrolyte.


In order to attest the feasibility and the concept of great-quality III – V devices, we focus our actual work on the developming of a tandem dual-junction solar cell, including a GaAS<inf>1−x</inf>P<inf>x</inf> top cell and a Si bottom cell. A simulation study of the top cell was performed. The impact of GaAS<inf>1−x</inf>P<inf>x</inf> absorber layer thicknesses, the temperature, and P composition x on cell efficiency are evidenced. In these structures, a tunnel junction was needed to interconnecting both the bottom and top cell. We comparing the simulated performance of two tunnel junction structure and we will show that the use of the GaAs (n+)/GaAs (p+) tunnel junction improve the performance of the currentvoltage characteristics. An optimal efficiency of about 16.27% was obtained with a thickness of about 1–m, P fraction x=0.37 and a temperature of 285 K.


According to the United Nations Office on Drugs and Crime, the Netherlands is one of the major world producer and exporter of synthetic drugs. In 2008, for example, 42% of ecstasy drug that was seized globally was produced in the Netherlands. In 2008, like many police agencies worldwide, Dutch law enforcement authorities began adopting a strategy of tight control and severe restriction of access to both the precursor chemicals, or raw chemicals that are essential for the production of synthetic drugs, as well as adjunct chemicals that are necessary to create the chemical synthesis during the production cycle. Access to essential hardware, special glass vessels that are needed for production of synthetic drugs, was also tightly controlled.


At repair-restorely works exist technological influence on work surface of details, which sizable the intensive lower of running rubbing and wear out processes. Between rubbing surfaces begin forming of new layer with thickness in proportion of the wear out, in result of this the friction between the surfaces is decrease. This article present the influence of additive "Rimet" to variation of wear out, change of roughness and speed of wear out. The research are conducted on machine for rubbing and wear out "MRW-1", over rubbing couple in type "tempered steel - bearing alloy". At research are received datas for weight change on roll and bearing alloy AO-20 and BO-30. also the values of the change of the geometry of the rolls and the change of the rolls and bearing alloys roughness by several sections. The received results are giving possibility for rating of ongoing processes at using additive "Rimet" on tracking of treatment and wear out stability of rubbing couples from "shaft-bearing".


ObjectiveTo observe the changes in morphology,structure,and ventricular function of infarct heart after bone marrow mononuclear cells(BMMNC) implantation.MethodsTwenty-four dogs were divided into four groups with random number table,acute myocardial infarction(AMI) control group,AMI-BMMNC group,old myocardial infarction(OMI) control group and OMI-BMMNC group,6 dogs each group.Autologous BMMNC were injected into infarct and peri-infarct myocardium for transplantation in AMI-BMMNC group and OMI-BMMNC group.The same volume of no-cells phosphate buffered solution(PBS) was injected into the myocardium in AMI-control group and OMI-control group.Before and at six weeks of cell transplantation,ultrasonic cardiography(UCG) were performed to observe the change of heart morphology and function,then the heart was harvested for morphological and histological study.ResultsUCG showed that left ventricular end diastolic dimension(LVEDD),left ventricular end diastolic volume(LVEDV),the thickness of left ventricular postwall(LVPW)in AMI-BMMNC group were significantly less than those in AMI-control group(32.5±5.1 mm vs.36.6±3.4mm,46.7±12.1 ml vs.57.5±10.1ml,6.2±0.6mm vs.6.9±0.9mm;P0.05).LVEDD,LVEDV,LVPW in OMI-BMMNC group were significantly less than those in OMI-control group(32.8±4.2 mm vs.36.8±4.4mm,48.2±12.9ml vs.60.6±16.5ml,7.0±0.4mm vs.7.3±0.5mm;P0.05).The value of eject fraction(EF) in OMI-BMMNC group were significantly higher than that in OMI-control group(53.3%±10.3% vs.44.7%±10.1%).Compared with their control group in morphological measurement,the increase of infarct region thickness(7.0±1.9mm vs.5.0±2.0mm,6.0±0.6mm vs.4.0±0.5mm;P0.05) and the reduction of infarct region length(25.5±5.2mm vs.32.1±6.2mm,33.6±5.5mm vs.39.0±3.2mm,P0.05) were observed after transplantation in AMI-BMMNC group and OMI-BMMNC group,no ventricular aneurysm was found in AMI-BMMNC group,and the ratio between long axis and minor axis circumference of left ventricle increased in OMI-BMMNC group(0.581±0.013 vs.0.566±0.015;P0.05).Both in AMI-BMMNC group and OMI-BMMNC group,fluorescence expressed in transplantation region was observed,the morphology of most nuclei with fluorescence was irregular,and the differentiated cardiocyte with fluorescence was not found in myocardium after transplantation.The histological examination showed more neovascularization after transplantation both in AMI and in OMI,and significant lymphocyte infiltration in AMI-BMMNC group.ConclusionBMMNC implantation into infarct myocardium both in AMI and OMI have a beneficial effect,which can attenuate deleterious ventricular remodeling in morphology and structure,and improve neovascularization in histology,and improve the heart function.


Using nonylxanthate, A.R.845, sodium dodecyl sulfate, styrenephosphonic acid and hydroxamate for collectors, flotation of tin ore which contained Ta, Nb and W was investigated after grinding of the ore under 400 mesh. Suspensions of the sample for flotation were buffered at a pH around 8 because of the large amount existence of Ca carbonate minerals in the ore, therefor, most of flotation experiments were carried out at natural pH. In this condition A.R.845 and styrenephosphonic acid were more effective to Ca minerals than rare metal minerals, while hydroxamate was a effective collector to rare metal minerals. 88 wt%S was removed and 94 wt%Sn, 96 wt%Ta, W and 97 wt%Nb were recovered from the sample by use of nonylxanthate. By use of sodium dodecyl sulfate, 98 wt%Ca was removed and 85 wt%Sn, 91 wt%Ta and 72 wt%Nb were recovered from the sample.


Cooperative communication is an effective way of achieving spatial diversity when it is impossible to employ multiple antennas. Recently, a new relaying technique, so called Soft Decode and Forward, has been proposed, which aims to combine the benefits of conventional relaying techniques, i.e. "Decode and Forward" and "Amplify and Forward", and to mitigate the shortcomings of those conventional methods. We study the error performance of two cooperative scenarios employing soft-DF. We propose a novel approach to estimate the bit-error probability and the equivalent channel SNR for relaying techniques of consideration in the paper that employ the BCJR-algorithm for decoding. We also consider the mutual information loss due to applying different encoders at the relay.


First, the paper develops a possible archetypal format for codifying the layouts of houses and plots. Examples of application to actual layouts are presented. Measures of ground coverage and density (floor space index) are calculated for these cases, using a simple spreadsheet model. Possible extensions to street type and urban layout (as previously suggested by Marshall, 2005) are then discussed.


In the literature several cases are described of new-onset psychosis in asymptomatic human immunodeficiency virus (HIV)-infected patients without provable organic or, apparently, psychogenic cause. The onset is acute or subacute, with delusions, hallucinations, bizarre behaviour, or affective disturbances. There may be mild cognitive impairment. The course may be short, lasting days to weeks, or chronic, lasting months to years. In some cases psychosis precedes HIV dementia or progression to AIDS and, soon, death. It is possible that the psychosis is directly induced by the virus itself in the same manner as HIV dementia is presumed to be.


One can identify the construction and transformation of three distinct systems of industrial relations in Britain over the last century. In contrast to the view that the state has been largely abstentionist in the sphere of industrial relations, or that, where intervention has taken place, it has been ad hoc, incoherent and reactive, this article makes two arguments in explaining this pattern of institutional construction. First, that the British state has been a central actor in the construction and 'embedding' of industrial relations institutions. Secondly, that broad processes of economic restructuring have created the context and trigger for state action. It is the timing and character of economic restructuring which explain the distinctive evolution of British industrial relations.


With the development of suitable radio-frequency generators, the determination of the optimum means for coupling to human tissue and the determination of the best range of radio frequency, it has become possible to kill tumours successfully. This article describes these developments and the subsequent design of a system that has been used to kill tumours


The paper presents a brief review of the history of collaboration between CFI/Transtional and Chinese scholars, as well as the achievements both of the partners have made in the past two decades. Facing a series of global and serious issues and problems, the paper indicates it necessarytostrengthen the worldwide cooperation.


Newly hatched caterpillars from a clutch of Heliconius erato phyllis (Fabricius, 1775) eggs can be cannibals or non-cannibals. Further, they are able to recognize kin and preferentially cannibalize unrelated eggs. This study analyzed differences in the development and survival to maturity of cannibal and non-cannibal caterpillars of this butterfly, as estimates of the costs and benefits of cannibalistic and non-cannibalistic behavior. The variables analyzed were egg weight and volume, number of days from hatching to adulthood, growth rate, pupal weight, Rev35-1-22.indd 1 23/02/2022 11:10 Revista Biotemas, 35 (1), março de 2022 2 J. De Nardin e A. M. Araújo wing area, mortality of immatures, and survival of immatures under starvation. There were significant differences for egg volume and weight (cannibal > non-cannibal) and for duration of the first instar and pupa (cannibal < non-cannibal). Mortality among cannibals and non-cannibals was not different, but survival of cannibals under starvation was significantly greater. Siblings of cannibals and non-cannibals did not differ for the same variables. Non-cannibals have the benefit of leaving more siblings but suffer the cost of slightly slower development. A brief discussion of the costs and benefits of cannibalism and non-cannibalism in this study, as well as in the available literature, is included.


The methanol extract and residual methanol fraction of Excoecaria agallocha L. (Euphorbiaceae) stem bark was investigated in this study by wheat rootlet and shoot growth inhibition, and antimicrobial bioassay. The methanol extract and residual methanol fraction showed high inhibitory effect on both the wheat rootlet (82-89%) and shoot growth (85-90%) compared to control. The methanol extract showed a better and dose related inhibition on both the rootlet and shoot growth compared to residual methanol fraction. The value of methanol extract for rootlet and shoot were and , and of residual methanol fraction for rootlet and shoot were and . The methanol extract and residual methanol fraction did not show any antibacterial activity against the tested microorganisms of clinical isolates Escherichia coli, Staphylococcus aureous, Pseudomonas aeruginosa, Proteus vulgaris and Bacillus subtilis. The plant has the potential to be a source of novel cytotoxic compound(s).


The subject innovation relates to a concrete distributor for high-rise buildings, the fixed unit mounted in the hole formed in the central slab in a building; Support means provided in the lower end of the fastening means; A fixed frame installed in the upper portion of the fixing means; Rotating means provided in the upper portion of the fixed frame; It characterized in that comprises a splitter which is installed on top of the rotation means, and according to the layer construction is the enlargement because the concrete distributor also therefore move no release the entire distributor or inconvenience as in the conventional art, and the disassembly of the dispenser according it is possible to prevent the delay of the construction period can be shortened construction period, there is an effect capable of reducing the construction cost in accordance with the shortening of the construction period. In addition, there are effects that the load applied on the slab during the enlargement of the building, there is an effect that can increase the work efficiency, wider range of operation.


Jean-Francois Lyotard's essay `Adorno as the Devil' had argued that Theodor Adorno's Philosophy of Modern Music was a `diabolic' work of `negative theology' which attributed to Schoenberg's music a secret redemptive power. However, in his later writings, such as the essays in The Inhuman, Lyotard has himself moved close to a `negative theological' position with respect to modernity, time, aesthetics and music. The paper uses the occasion of Lyotard's own theologically inspired essays on music, `God and Puppet' and `Obedience', to re-evaluate the following: Adorno's claims that music transcends mere language and `reaches' for the theological; and more general claims within modern western culture on behalf of music's ability to express the inexpressible. The argument is that the music as negative theology position is not inherently metaphysical but rather that it reflects the importance of the `unsayable' to modern conceptions of reason. In resisting the `closure' of the modern narrative of reason, music, as a temporal art, has often given expression to the more radical forms of alterity present within modern forms of time. In other words, negative theology is not the discourse of the devil; it is the impossible discourse of western reason and its internal fracturing.


Abstract Brillouin zones in reciprocal space are most logically defined by Brillouin's original method, solely in terms of the Full Bravais Lattice giving the full translational symmetry of the crystal. Another method, which rejects zone boundaries of vanishing structure-factor, is illogical, both because it is possible to have an energy discontinuity of electron states across a plane of zero structure-factor, and because it ignores the energy continuity within Brillouin's original zones. The energy is always continuous within the true Brillouin zones, which must contain two electron states for each unit cell of the Full Bravais Lattice.


The South China Sea (SCS) territorial disputes have become one of the most significant security challenges in the East Asian Supercomplex (EAS). Described in Buzan and Wæver's classic study as a Great Power Bipolar Supercomplex defined by China and Japan, the emergence and actions of South Korea and Indonesia as regional powers have rendered the EAS multipolar and unusually volatile. As the hierarchy in the EAS transforms into a multipolar one, the securitization of China has allowed Japan and South Korea to facilitate the capacity building efforts of Southeast Asian states at the expense of China. As a result, the littoral states surrounding the SCS have taken advantage of this strategic competition in order to advance their own interests.


EDITORIAL COMMENT": These authors have previously reported the importance of sickle cell anaemia as a cause of maternal mortality in Bahrain (A). We have accepted this paper for publication although sickle cell anaemia is rare in Australia so that our readers can see the lesson learnt from this very large experience of 571 cases, namely that prophylactic blood transfusion is not indicated unless the haemoglobin value falls below 6 g/dL. We presume that all of these patients would require blood to be cross‐matched and available at delivery in case of postpartum haemorrhage.


Aluminum (Al) toxicity severely restricts crop growth and productivity in acidic soils. The rubber tree is one of the most economically important crops in tropical regions, which is tolerant to high concentrations of Al in sand or hydroponic culture conditions compared with other plants that have been reported. However, the mechanisms of Al tolerance in rubber trees remain unknown. In this study, we conducted a transcriptome and metabolome analysis for rubber tree sapling roots treated with 200 mM Al for 0 (CK), 2 or 5 days, respectively. Compared with the CK, a total of 9534 differentially expressed genes (DEGs) and 3821 differentially expressed metabolites (DEMs) were identified in 2 d of Al treatment. There were 10,373 DEGs and 4636 DEMs after 5 d of Al treatment, and 1626 DEGs and 1674 DEMs between 2 and 5 d of Al treatment. The DEGs mainly concentrated in transporters, transcription factors (TFs), cell wall biosynthesis and antioxidant systems, and the DEMs were mainly focused on lipids and lipid-like molecules, organic acids and derivatives, organic oxygen compounds, phenylpropanoids and polyketides. The combined transcriptome and metabolome analysis indicated DEGs and DEMs involved in ABC transporters, glutathione metabolism, flavonoid biosynthesis and phenylalanine metabolic pathways were identified to be closely associated with the Al tolerance of rubber trees. Our study elucidated the mechanism of rubber trees' tolerance to Al at the transcriptional and metabolic levels, which provides a theoretical basis for the study of Al tolerance both for rubber trees and other woody plants.


In the present dual‐probe microdialysis study the effects of intrastriatal perfusion with the tridecapeptide neurotensin(1–13) [NT(1–13)] and its active fragment NT(8–13) on striatopallidal GABA and striatal dopamine release were investigated. The modulatory action of NT(1–13) on D2 receptor‐mediated inhibition of striatal and pallidal GABA release was also studied. Both intrastriatal NT(1–13) (100 nM) and NT(8–13) (100 nM) increased striatal (139 and 149% respectively) and pallidal (130 and 164%) GABA release, and this effect was antagonized by intrastriatal perfusion with the neurotensin receptor antagonist SR48692 (100 nM). A similar increase (155%) in striatal dopamine release was observed following intrastriatal NT(1–13) (100 nM), but not NT(8–13) (100 and 500 nM). However, at the highest concentration studied (1 μM) NT(8–13) was associated with a rapid increase (130%) in striatal dopamine release. In a second study intrastriatal NT(1–13) (10 nM) counteracted the inhibition of striatal and pallidal GABA release induced by pergolide (500 and 1500 nM). The inhibitory action of the D2 agonist was restored when SR48692 (100 nM) was added to the perfusion medium. These results suggest that in the neostriatum the neurotensin receptor located postsynaptically on the striatopallidal GABA neurons seems to differ from the neurotensin receptor located on dopaminergic terminals, as indicated by the relative lack of effect of NT(8–13) on striatal dopamine release. Furthermore, the ability of NT(1–13) to counteract the pergolide‐induced inhibition of both striatal and pallidal GABA release strengthens the evidence for antagonistic receptor‐receptor interaction between postsynaptic striatal neurotensin and D2 receptors located on striatopallidal GABA neurons.


The reduction limit of critical heat flux(CHF) in vertical tube under flow oscillation condition,obtained by a temperature response model,was modified using the CHF experimental data of Umekawa and Ozawa et al..Based on the modified reduction limit of CHF,a new correlation was proposed to predict the CHF under flow oscillation condition in vertical tubes at low velocity and pressure conditions.The comparisons between the prediction of the new correlation and experimental data show a reasonable agreement with a mean error of 11.5%,which is smaller than the error of prediction using Kim correlation,21.04%.


After the 1994 genocide against the Tutsi in Rwanda, the post-genocide government spearheaded the creation of genocide commemorations. Over the past two decades, political elites and survivors' organizations have gone to great lengths to institutionalize the memorialization, including creating laws to protect the memory of the genocide from denialism. Ordinary Rwandans have responded to the annual commemorations using creative means of support for and disagreement with the government's interpretation of their shared violent past. Music has been used as citizen-driven tool to both spread and criticize genocide memorialization nationally and beyond. While scholars have explored the politicization of state-organized mechanisms such as memorials, citizen-driven creative means remain largely unexplored. Addressing this gap in Rwandan memory scholarship, I examine how Kizito Mihigo, a famous post-genocide musician, used his individual memory of surviving the genocide against the Tutsi through music to contribute and respond to the annual commemorations of the genocide. I argue that Mihigo's story and commemoration songs were politicized from the start but were intensified when he used his music to go beyond promoting genocide commemorations to questioning the events and when he pleaded guilty to terrorism charges.


Objective
To evalutate the efficacy and learning curve of holmium laser enucleation of prostate on patients with benign prostatic hyperplasia (BPH).

Methods
We retrospectively analyzed the first 60 surgical cases of a surgeon who was experienced on transurethral resection of prostate (TURP) and newly using holmium laser enucleation of prostate (HoLEP). Participants were divided into three groups (the early surgery group, middle group and late stage group), based on surgical time. There were 20 patients in each group, while the operative duration time, postoperative hemoglobin, urethral catheterization duration time, postoperative hospitalization duration, enucleation efficacy, and the change of hemoglobin were compared. The learning curve was evaluated by enucleation efficacy.

Results
The early group, middle group and late surgical enucleation of the prostate enucleation time gradually shortened, the efficiency gradually increased, there were statistically significant differences (P 0.05).

Conclusions
It is available for experienced TURP surgeon to use HoLEP on patients with BPH. As the surgeon become experienced, the enucleation efficacy is satisfied.

Key words:
Prostatic Hyperplasia; Lasers, Solid-State; Prostatectomy


The Global Leadership Initiative on Malnutrition (GLIM) criteria have been recently launched by consensus of the major nutrition societies. GLIM criteria are partly constructed on the previous definition of malnutrition developed by the European Society of Clinical Nutrition and Metabolism (ESPEN). We aimed to assess malnutrition according to the ESPEN and GLIM criteria at baseline and to determine the corresponding risk of mortality during a 4‐year follow‐up in community‐dwelling older adults from the SarcoPhAge (Sarcopenia and Physical Impairment with advancing Age) study. The relationship between malnutrition and incidence of 4‐year adverse health consequences (institutionalization, hospitalization, falls, and fractures) was assessed.


This paper investigates the annular type LIM disregarding the edge effect. Using the Fourier transform, the FEM solution is translated in the space of wave numbers. The effect of velocity V on eddy current is clarified in the moving coordinate. Also, the Fourier spectrum of body force is divided into forward, backward and alternating components to clearly indicate the effect of V on such components.


We have observed at high resolution (λ/Δλ=5×10 4 ) and good signal-to-noise ratio (between 50 and 250, with the majority having S/N≥100) a group of 18 early-type stars in the solar neighborhood in the region of the K I λ7699 resonance line, to detect interstellar absorptions due to K I. Using our detections, and upper limits, we measure K I column densities and estimate those of H I along these lines of sight


The personal writing of children in English class is considered in the light of recent research on creative processes. It calls for divergent rather than convergent thinking, and a task-oriented rather than ego-oriented approach towards the work. Writing done in the classroom has evident advantages over that done at home. The most effective way of stimulating good writing will vary with the age, the sex and the individuality of the child. The moment of starting to write is fraught with particular difficul ties, which may be lessened by the use of 'synectics' technique.


The genus Jatropha belongs to the Euphorbiaceae family, widely distributed in the wild or semi-cultivated areas in Central and South America, Africa, India and South East Asia. Ethnopharmacological studies show that the leaves and other parts of the Jatropha curcas are used in traditional medicine to treat wounds, fever, rheumatism, mouth infections, cancer, toothache, convulsions, cough and fever. Evaluation of J. curcas have demonstrated their different pharmacological effects, among them anticoagulant, coagulant, antidiabetic and neuroprotective. Phytochemical investigation on the chemical constituents of the J. curcas leaves have resulted in the isolation and structure identification of flavonoids and its glycosides, sterols, steroid sapogenins, alkaloids, triterpenes, and phorbol esters diterpenes, the main toxins present in oil and seeds, leaves, stems, flowers and roots of J. curcas. Pathological symptoms are related with the consumption of J. curcas in any form, oil, seeds, seed cake or extracts; however the young leaves may be safely eaten.


The aim to produce infant bed by using bamboo and bamboo charcoal fabrics. This baby bed will be highly Anti-Microbial smooth, soft, herbal smell and back rest material will be having the cooling property and fragrance with more comfortless for the babies. Baby bedding is also known as bed cloths, is the material laid above matters for warmth, protection of matters and it is washable and comfort for sleeping. It improve more absorbency and implement natural printing and antimicrobial finish. The treated fabric will be analysed by comfort properties like air permeability and wicking property. The finished fabric is tested, further to develop the end product and the result shows that end product is more comfortable for the usage


Magnetic properties of Sm 0 . 2 Ca 0 . 8 Mn 1 - x Ru x O 3 (x=0, 0.04, and 0.08) are investigated in the temperature range 4.2-240 K, external magnetic fields up to 15 kOe and hydrostatic pressure up to 12 kbar. Transport properties of Sm 0 . 2 Ca 0 . 8 Mn 0 . 9 2 Ru 0 . 0 8 O 3 are also investigated in the temperature range 77-280 K and under pressure up to 10 kbar. It is found that for a pristine phase (x=0), hydrostatic pressure increases the ferromagnetic domains embedded in an antiferromagnetic matrix, and slightly decreases the Neel temperature. The effect of pressure on the magnetic interactions depends upon Ru doping. For Sm 0 . 2 Ca 0 . 8 Mn 0 . 9 6 Ru 0 . 0 4 O 3 an applied pressure decreases both Curie and Neel temperatures, but enhances the ferromagnetic fraction. In the case of Sm 0 . 2 Ca 0 . 8 Mn 0 . 9 2 Ru 0 . 0 8 O 3 an applied pressure suppresses the ferromagnetic interactions and surprisingly increases the resistivity. To the best of our knowledge this is the first time that such an effect was observed in perovskites. All of the above observations are discussed in the context of phase separation.


We have engineered conditionally‐immortalized mouse astrocytes to express β‐galactosidase or GAD65 in a tetracycline‐controlled fashion. The engineered cell lines, BASlinβgal and BASlin65, divide at 33°C but cease division at 39°C. We carried out morphological and biochemical analyses to further understand GABA production and release, and to determine the suitability of these cells for transplantation. Using the BASlinβgal cell line, we showed a dramatic regulation of β‐galactosidase expression by tetracycline. The BASlin65 cell line showed functional GAD65 enzymatic activity and GABA production, both of which were suppressed by growth in the presence of tetracycline. When cultured in the absence of tetracycline, BASlin65 cells have a total GABA content equal to or greater than other GABA‐ergic cell lines. Immunofluorescence microscopy revealed that GAD65 had a distinct perinuclear localization and punctate staining pattern. GABA, on the other hand, showed diffuse staining throughout the cytoplasm. BASlin65 cells not only synthesize GABA, they also release it into the extracellular environment. Their ability to produce and release significant amounts of GABA in a tetracycline‐regulated manner makes BASlin65 cells a useful cellular model for the study of GABA production and release. Furthermore, their non‐tumorigenicity makes them excellent candidates for transplantation into specific regions of the brain to provide a localized and regulatable source of GABA to the local neuronal circuitry. J. Neurosci. Res. 3:302–310, 2000 © 2000 Wiley‐Liss, Inc.


RT @John_Rouleau: My favorite part of #mnleg session is when members pretend there are tons of people who aren't lobbyists/activists watchi…


The article discloses the educational, developmental and educational functions of a didactic complex of information support.The technological approach in education involves a clear statement of learning goals and methods of their guaranteed achievement, and the competence-based approach as an output result implies a certain level of formation of professional competencies.Main aspects and features of the practical implementation of the indicated stages design of information technology of education in the formation of professional competencies among university graduates The essence of information technology of education has been disclosed Analyzed scientific and scientific-methodical literature on the problem of higher professional education, made it possible to highlight certain directions in the interpretation of the essence of the concept of "information technology of education".


A bio-based benzoxazine surfactant is synthesized using amino acids as an amine source, and may have potential use in cosmetics and cleaning products.


By taking account the recommendations of the International consensus built up by the Committee of the US Endocrinology Association (2007), the 2006 normative documents by the Ministry of Health and Social Development of the Russian Federation and on the basis of the their many years' clinical and pedagogical experience, the authors have prepared a lecture for laboratory study specialists, obstetricians, endocrinologists, and other physicians who are responsible for the management of pregnant women. Concise data on the physiology of the thyroid in healthy pregnant women and in those who reside in the iodine-deficiency areas are given. The updated data on the clinical types of gestational thyroid pathology, the effects of thyroid hormone deficiency and excess on a future mother, the placenta, and fetal growth and development are summarized. There are arguments in favor of and against the expediency of total and selective screening for impaired function of the thyroid and the general principles of the laboratory diagnosis of its diseases during pregnancy. Original algorithms for interpreting the laboratory parameters of the thyroid system during gestation in the routine situations of the primary diagnosis of various diseases of the thyroid in obstetric practice and its further monitoring during treatment are discussed.


Synchronization of the iNET communication link is essential for implementing the TDMA channel access control functions within the transceiver MAC transport layer, and providing coherent signal demodulation timing at the transceiver PHY layer. In the following implementation, the 1588 timing reference source is the GPS receiver. Because it is being used in the Ground Station Segment and Test Article Segment, it becomes feasible to utilize the 1588 timing reference for cross-layer (MAC+PHY) iNET transceiver synchronization. In this paper, we propose an unified iNET transceiver synchronization architecture to improve iNET transceiver performance. The results of the synchronization performance analysis are given.


The Semantic Web is composed of applications that share, exchange and link self-describing data (instead of text) via the World Wide Web rendering it a kind of global, distributed database – with a lot of semi-tidy information in it that may also allude to very different conceptualisations. To formally specify the data and the conceptualisation, there exists an architectural agreement in form of the famous Semantic Web representation layer cake. The cake (http://www.w3.org/2001/09/06-ecdl/slide17-0.html) characterizes different language layers on which data may be self-describing (cf. a slightly modified version on the vertical axis in Figure 1).


The policing of political protests is one of the most political and controversial aspects of the police role. The approach that police take to a particular protest or protest movement is likely


With the objective of establishing values for haematological picture in Santa Ines breed sheep, raised in the Metropolitan Mesorregion of Recife, an erythrogram was performed in a total of 102 animals, clinically healthy and kept under same nutrition, environment and climatic conditions. The influence of age and sex upon each one was evaluated. Results were analyzed by Tukey's test at level of significance of P < 0.05 and revealed mean values of erythrocytes: 9.19 ± 2.63 x 10· Imm3 packed cell volume (PCV): 30.07 ± 5.30 %; haemoglobin (Hb): 10.67 ± 2.68 g/dl; mean corpuscular volume (MCV): 34.81 ± 11.71 m3; mean corpuscular haemoglobin (MCH): 12.27 ± 4.81pg; mean corpuscular haemoglobin concentration (MCHC): 35.34 ± 5.43%. A significant difference was observed between sex only in the erythrocytes, where male showed average values higher than the female. The values of PCV and Hb decreased significantly with the advance in the age of females, where the younger ones presented higher values. ln conclusion, the mean values obtained under those conditions and in the region studied can be influenced by sexual and age factors having an influence on the erythrogram.


Kim Bennell is an academic physiotherapist and currently Professor and Foundation Director of the Centre for Health, Exercise and Sports Medicine at the University of Melbourne, Australia. Here she leads a multidisciplinary team from physiotherapy, medicine, science and human movement. She …


A cross sectional study was conducted on 164120 non-vaccinated layer birds of 96 farms in six upazilas (Sadar, Batiaghata, Dumuria, Dighulia, Rupsha and Fultala) of Khulna district to determine the seroprevalence of Salmonella infection ( S. pullorum and S. gallinarum ) during the period from August 2009 to July 2010. Sera samples were collected from 1268 layer birds of different ages and the birds were selected through a disproportionate stratified random sampling technique based on the flock size of each farm. Sera samples were tested by Serum plate agglutination (SPA) test applying commercial Salmonella antigen (Nobilis® SA, Intervet International B.V. Boxmeer- Holland) to detect the presence of antibodies against Salmonella . The overall seroprevalence of Salmonella infection was recorded as 65.9%. The significantly higher seroprevalence (76.6%) of Salmonella infection was recorded in layer birds of >56 weeks of age than those of other age groups. Seasons had significant influence on the seroprevalence of Salmonella infection. The seroprevalence was significantly higher in summer (82%) than that in rainy (66.8%) and winter (50%) seasons. The location of farms, i.e. upazilas also had significant association with the occurrence of Salmonella infection. The seroprevalence significantly differed between the different categories of flock size. The flock size of 5001 and above had the highest seroprevalence (81.4%) among other categories. It may be concluded that above 60% layer birds in 92 out of 96 farms are infected with Salmonella organism, which requires keeping of vigilant eye of the poultry farmers and the hatchery owners in the control of Salmonella infection in poultry farms. DOI = http://dx.doi.org/10.3329/bjvm.v9i1.11206 Bangl. J. Vet. Med. (2011). 9(1): 27-31


It is a recognized view that particle size could play a significant role in catalytic performance. To obtain the nanoparticles with the different size, a series of bimetallic PtPd/SiO2–Al2O3 catalysts subjected to hydrothermal treatment in different time were prepared and applied for NO oxidation under diesel exhaust. The experimental results confirmed that the average noble particle size was gradually increased at a different variation rate, along with aging time. An increasing of average particle size resulted in the reduction of the corresponding NO turnover frequencies (TOFs) by different degrees. Thus, a new sight on the relationship between particle size and NO catalytic activity is obtained. In the aging process, the overall trend of noble metal particles got larger along with receding NO catalytic performance, yet in a period, a few small particles presented more bridged/chelating nitrate and ionic nitrate species, further retarding its rate of loss activity.


Objective:To explore the prevalence of and to identify possible risk factors for chronic pain after surgery for femoral hernia. Background:Chronic pain has become a very important outcome in quality assessment of inguinal hernia surgery. There are no studies on the risk for chronic pain after femoral hernia surgery. Methods:The Inguinal Pain Questionnaire was sent to 1967 patients who had had a repair for primary unilateral femoral hernia between January 1, 1997 and December 31, 2006. A follow-up period of at least 18 months was chosen. Answers from 1461 patients were matched with data recorded in the Swedish Hernia Register and analyzed. Results:Some degree of pain during the previous week was reported by 24.2% (354) of patients. Pain interfered with daily activities in 5.5% (81) of patients. Emergency surgery (OR = 0.54; 95% CI = 0.40–0.74) and longer time since surgery (OR = 0.93; 95% CI = 0.89–0.98 for each year added) were associated with lower risk for chronic postoperative pain, whereas a high level of preoperative pain was associated with a higher risk for chronic pain (OR = 1.17; 95% CI = 1.10–1.25). Surgical technique was not found to influence the risk for chronic pain in multivariate logistic regression analysis. Conclusions:Chronic postoperative pain is as important a complication after femoral hernia surgery as it is after inguinal hernia surgery. In contrast to inguinal hernia surgery, no risk factor related to surgical technique was found. Further investigations into the role of preoperative pain are necessary.


Introduction: Assessment of the renin-angiotensin-aldosterone system has been recently granted a much greater role in the evaluation of patients with arterial hypertension. There is no single test efficient in selection of patients for second-step etiological investigation. Methods: Altogether, 198 consecutive patients − 119 women (60%) and 79 men (40%) – hospitalized in years 2009–2011 at the Clinical Department of Endocrinology Medical University of Bialystok were diagnosed with primary aldosteronism. In each patient, plasma renin activity and plasma aldosterone concentration (basic and after 2 l NaCl infusion) were evaluated. Results: The percentage of patients with plasma aldosterone concentration ≥15 ng/ml was 53 and the percentage of patients with plasma renin activity ≤0.1 ng/ml/h was 20. The percentage of patients screened for primary aldosteronism in which the aldosterone:renin ratio exceeded consecutive cut-offs of 20, 30, 40 and 50 were respectively 57, 45, 34 and 29. Among 15 patients in which plasma aldosterone concentration after infusion of 2 l of saline was ≥6.5 ng/dl (8.6%), 13 (6.6%) were diagnosed with primary aldosteronism. Conclusion: The obligatory use of tests confirming autonomy of aldosterone secretion in patients screened for primary aldosteronism seems cost-effective in limiting the number of patients for further diagnosis.


A research study on 'Psychosocial Implications of Involuntary Childlessness in the Indian Cultural Context' has been undertaken to understand and appraise the societal notions on infertility and the values attached to parenthood and perceptions of individuals experiencing infertility regarding parenthood their experiences about the same and its implications on their psychological self marital and familial relations. In context of the same a small exercise on concept mapping was planned to understand the prevalent notions of involuntary childlessness in the contemporary middle upper middle class families of the society with a view to build a conceptual framework for the research study. The results of the concept mapping exercise are presented here. (authors)


Summary.  Background: The A subunit of factor XIII (FXIII‐A) functions as an intracellular transglutaminase (TG) in the megakaryocyte/platelet lineage, where it probably participates in the cytoskeletal remodeling associated with cell activation. However, so far, the precise role of cellular FXIII (cFXIII) and the functional consequences of its absence in FXIII‐A‐deficient patients are unknown. Objectives and methods: In this study, we used platelets from four patients with congenital deficiency of FXIII‐A to study the role of cFXIII in platelet functions. Results: We found that FXIII‐A represents the only detectable source of TG activity in platelets and that the binding of fibrinogen in response to thrombin receptor agonist peptide (TRAP) stimulation was significantly reduced in platelets from the patients. In agreement with this, in control platelets, monodansyl‐cadaverine (MDC), a competitive amino‐donor for TGs, inhibited fibrinogen binding induced by TRAP in a dose‐dependent manner. Moreover, upon adhesion to fibrinogen, normal platelets incubated with MDC as well as FXIII‐A‐deficient platelets showed a distinct extension pattern with reduced lamellipodia and increased filopodia formation, suggesting a delay in spreading. Conclusions: These findings provide evidence for the direct involvement of cFXIII‐dependent TG activity in the regulation of platelet functions.


The development of key materials for proton exchange membrane fuel cells including electrocatalysts, electrodes, proton exchange membranes and bipolar plates in DICP are introduced in this paper. The basic fundamentals and the most recent progress in the key materials have been discussed. The preparation methods of electrocatalysts have been reviewed. Characteristics of various electrode preparation methods are also introduced. A new electrode design and prospective manufacturing methods are indicated. The disadvantages of the present exchange membrane are presented. The results of proton exchange membrane degradation mechanisms are given. Studies of the Nafion/PTFE membrane, blending membrane and PBI membrane are reviewed. Developmental trends of the membrane in both the medium and long term are previewed. Different bipolar plates are compared.


The weather directly impacts ventilation systems, especially large industrial systems found in underground mines. Underground mine ventilation systems have high cost implications that add to the financial strains and uncertainties of future mining operations. In addition, the dynamic nature of underground ventilation systems makes the accurate prediction of underground conditions extremely difficult using traditional steady-state methods. Therefore, improved prediction methods of dynamic underground environmental conditions are needed to ensure cost-effective ventilation systems. This paper investigates simulating the sensitivity that underground ventilation systems have to fluctuating ambient conditions. Simulation software was applied to a case study on a gold mine in South Africa. The results showed that transient software can now be applied to entire mine ventilation systems, and can improve predicting the underground environment because of fluctuating ambient conditions.


The purine contents of alcoholic beverages are usually quantified by high-performance liquid chromatography coupled with a UV detector and preceded by hydrolyzing samples with perchloric acid. In this article, we have developed an improved hydrolysis procedure in which sulfuric acid is used as the hydrolysis reagent. Through experiments under different conditions, we established the optimum sample pretreatment technique. This whole method enables four purine bases (namely, guanine, adenine, hypoxanthine, and xanthine) in beer to be determined with recoveries close to 100%, a repeatability error of less than 1%, and improved limits of detection for all the analytes was less than 5 μg/L. The overall method was successfully applied to the determination of purines in marketplace alcoholic beverages. The results showed that beers had far more total purine content (average content: 72.87 mg/L) than other alcoholic beverages (average content: 0.22 mg/L in Chinese spirits, 45.99 mg/L in rice wine, and 29.67 mg/L in wine).


This is a revision of J.R. Krueger's reading and translation of the Ordos Prince Sagang Sechen's moralistic poem written in 1662 in seventy-nine alliterative quatrains attached to his Erdeni-yin tobči, the Jewel Summary, the 'classical' chronicle of pre-modern Mongol historiography. A new reading and interpretation is offered with ample commentary.


Three finite element techniques are compared with a simple method based on conventional magnetic circuit theory. The 2D-FE method used is based on the common vector potential technique. The 3D-FE method employed uses the total and reduced magnetic scaler potential representation. It is shown that while the simple method yields only approximate answers all the finite element models give satisfactory results. The work is supported by experimental results. >


driven to arrive at the pyramid's bottom up a significant source of business prototype inventions Even though it remains undisputed that for corporations to flourish by increasing revenue, achieve competitive effectiveness and simplification of business process, managers must have a good understanding of how business approach work in a long-term perspective, the educational community however has merely provided initial glimpse on the subject matter so far. The development of African society and sometimes fast cyclical changes has a major impact on the activities of competing firms and business environment. African economic growth has been very moderate in contemporary times, and is likely to remain moderate in the near future. The World Bank (2018) forecasts that the economy will remain in a state of Abstract: The purpose of this study is to examine the activities of a competing firm in a long-term perspective: revenue increase, effectiveness of competition, simplification of business processes and Coca-Cola Nigeria Plc was adopted as the case study. Three research questions and hypotheses were raised to solve the research problem. Descriptive survey technique using quantitative analysis method was adopted as the research design. The population of study comprises of the employees of Coca-Cola Nigeria Limited and 100 respondents were randomly selected for the study. The instrument for data collection is the carefully structure questionnaire. Findings revealed that long-term competitive strategy does significantly influence revenue increase; there is significant relationship between long-term competitive strategy and effectiveness of competition; and long-term competitive strategy does not significantly influence simplification of business process. The study however recommended that competitive strategies should be designed with revenue increase in mind; strategies should be put in place to achieve effectiveness of competitiveness; and ease of doing business should be given better attention in order to continue to remain relevant.


In recent years scientists have noticed that attention to the traditional view of the intelligence is no longer limited to the cognitive perspective only where psychologists have found the importance of the emotional side of the human because of the increased impact conscience in human life and is inseparable from thinking and then there is a full conviction that there is no duplication (Gardner, Salovi, Mayer, 1990) and Coleman (1995) find that they agree that traditional tests of intelligence will not give a complete picture of the behavior of the individual and not enable us to test the predicting and success the future,


Problem Definition: Many production systems deteriorate over time as a result of load and stress caused by production. The deterioration rate of these systems typically depends on the production ra...


A somewhat abstruse model recently formulated by Alonso is introduced and analyzed. The nature and certain structural properties of the model are examined and its general form is identified. The salient feature of the model is its simultaneous and consistent determination of the totals of the endogenous variables and of their constituent parts. The model can be viewed as an integration of substantive (producing–causal) submodels with a structural–formal (distributive) submodel. The integration is based on the dual roles of two endogenous variables both as normalizing factors and as explanatory factors. The last role is justified by the factors' representation of relative (inverse) mean cost of interaction. A statistical-independence postulation is also identified as an underlying statement of the model.


Recent advancement in the communication technologies creates an opportunity for the effective use of nowcasting – predicting the weather over short periods and communicating the predictions to the public in real time. Current nowcasting systems using weather radar images in the Czech Republic are built on traditional algorithms and numerical weather models. The objective of this work is to research the possibilities of using neural networks for processing of weather radar image sequences as an enhancement to the existing nowcasting methods. I propose and test a convolutional neural network as a solution for two tasks – interpolation and extrapolation of a sequence of weather radar images. In both tasks, the proposed network achieves promising results. Quantitative comparison of my network and the currently used method COTREC ended in favour of the proposed network. The qualitative evaluation shows multiple benefits of my solution – the ability to capture the change of the radar echo intensity and shape. The results of this work create space for deeper research in this field.


*e-mail: firstname.lastname@example.com Abstract. Polymers are widely used in cement mortar and concrete modification due to their significant role in improving the overall performance of cement-based materials. Their physical interaction is well-accepted, while less attention is given to chemical interaction between the polymers and cement. Through a review of prior arts, chemical interactions are discussed and summarized in this paper. Various chemical interactions may take place between cement and different types of polymers. Understanding these chemical interactions will play an important role in clarifying the relationship between microstructure and macrostructure of polymer-modified cementitious materials. Authors expressed and proved the conviction that the organic-inorganic (Polymer-Portland cement) composite with some components chemically bonded, in parallel to the physical interaction, will be the next stage in concrete technology progress.


A new theory and methodology to optimize subgroup parameters were established by the use of Chebyshev approximation. The optimization of the fitting method was realized by the minimax approximation provided by the Remes algorithm. As for the moment method, a new definition for moments was proposed to cure the poor reproducibility of effective cross section by the original moment method. The new moment method uses transformed Chebyshev polynomials as orthogonal bases. This method is mathematically stable and the efficiency was verified by a numerical example. It was also shown that use of preconditioning can furthermore enhance the efficiency. The first dominant term of the new moments can be approximated by old moment definition σα with α= 0.1–0:6, including the case with α=−1/2. This fact can explain the efficiency of the reservation of half-integer moments in the reproducibility of effective cross section that was mentioned by Unesaki.


As Internet users increasingly post images to express their daily sentiment and emotions, the analysis of sentiments in user-generated images is of increasing importance for developing several applications. Most conventional methods of image sentiment analysis focus on the design of visual features, and the use of text associated to the images has not been sufficiently investigated. This paper proposes a novel approach that exploits latent correlations among multiple views: visual and textual views, and a sentiment view constructed using SentiWordNet. In the proposed method, we find a latent embedding space in which correlations among the three views are maximized. The projected features in the latent space are used to train a sentiment classifier, which considers the complementary information from different views. Results of experiments conducted on Flickr and Instagram images show that our approach achieves better sentiment classification accuracy than methods that use a single modality only and the state-of-the art method that jointly uses multiple modalities.


Asymmetric and porous polysulfone (PSf) membranes were prepared by wet phase separation. Binary (PSf)/N,N-dimethylacetamide (DMA) solutions with polymer concentrations of 12.5–30 wt % were cast in thicknesses of 80–700 μm and immersed in a coagulation bath of pure water. The morphology of the formed membranes' cross sections consisted of a cellular structure and macrovoids; the cellular structure density was highest when the cast solution contained about 21 wt % PSf, regardless of the cast thickness. The membranes' pure water permeability decreased as the cast thickness increased. The instantaneous onset of the turbidity, regardless of the PSf content and cast thickness, its steep growth, and relatively high end value were the main characteristics of the turbidity phenomena taking place during the formation of the protomembranes. Again, the membrane-forming system with a PSf/DMA solution with about 21 wt % polymer, regardless of the cast thickness, had the highest turbidity end value. The shrinkage of the cast solutions into the corresponding protomembrane was also examined quantitatively. Inverse experiments showed that the direction of the gravitation field had no influence on the shrinkage of the membrane-forming ternary system or the membranes' morphology and its water permeability. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 1667–1674, 2005


Studies have shown that high systolic and diastolic blood pressure in patients, along with known risk factors for cardiovascular disease...


In order to maintain the temperature of a space optical remote sensor in orbit,a thermal control system is designed.The thermal control strategy is primary passive thermal control and assistant active thermal control.A simple simulation of the complicated orbital environment is made,and beta cloth is chosen to prevent AO.Three extreme conditions are confirmed based on its work patterns and heat fluxes.Thermal control design is primary concentrated on the sun-oriented work pattern in low temperature condition.The result of thermal balance test show that the thermal control system meets the requirement of mission,and the thermal design is feasible.Some guidance and reference are gotten from the research jobs for other analogous spacecraft.


where r is the risk-free rate of interest, T is the time when the option expires, t is the current time, S̃(T) is a lognormal random variable related to the stock price S(T) at time T, k is the exercise price, and x+ :=max(x,0). In insurance terms, (L! k)+ represents the indemnity payment on a policy with a loss of L and a deductible k. The Black–Scholes price can also be regarded as the discounted insurance charge (see Gillam and Snader [18] or Lee [25]). It is easy to compute the insurance charge under


Case report illustrates obstruction encountered in a patient with end‐stage dilated hypertrophic cardiomyopathy (HCM) who underwent LVAD implantation. The morphology reversed in early postoperative period to HCM. Pump replacement required coring of the ventricular muscle. Dilated end‐stage hypertrophic cardiomyopathy can revert back to the original morphology on decompression.


Pregnancies and deliveries need to be managed in a "continuum of care" across all levels of health care service provision. For this purpose, many countries maintain a "Perinatal Registry" – an electronic database in which relevant information related to pregnancy and childbirth (obstetrical history, risk factors, test outcomes, etc.) are periodically collected and evaluated. To date, such a system is not routinely used in Ukraine. However the importance and demand is reflected in a newly adapted concept by MOH Ukraine [1] where it was stated that the creation of perinatal registry is a priority task. The Ukrainian-Swiss Mother and Child Health Programme has supported Volyn Oblast health care authorities in the joint development of such a perinatal registry according to the specific local needs. The registry is an open source software tool that is accessible through a secure internet line and will support the health care providers at secondary and tertiary level in collecting and evaluating perinatal data – in particular for high risk pregnant women. The tool enables better decision-making, better quality of antenataland perinatal care and a reduction of neonatal and maternal mortality. Upon successful piloting in two facilities, the system will be scaled-up to the whole Volyn Oblast. 1. BACKGROUND Most health care services are provided at different levels of care, depending on the complexity and risk the intervention or service entails. A "referral system" is of particular importance in pregnancy and childbirth, as a range of potentially life-threatening complications require management and skills that are only available at higher levels of care [2]. The neonatal mortality (death during the first 28 days of life) accounts for a large proportion of child deaths in many countries, especially in low-income settings. In Ukraine, the neonatal mortality is 8 deaths per 1'000 live births while the average figure for high-income countries is 3.1 [3] [4]. A well organized referral system allows creating a so called "continuum of care" [5] has big potential to reduce neonataland also maternal mortality (Millennium Development Goals 4 and 5) and to improve the effectiveness of the heath care system. In order for such referral system to function, it is essential to have clearly defined referral patterns, timely referrals and access to relevant clinical information at the receiving health facility. In the Ukrainian health care system, information related to pregnancy and childbirth is routinely collected on paper at hospital level. At a central level, there is a lack of real-time information concerning the number of pregnant women, their potential risk factors and their location. There is also a low capacity to identify and manage risk pregnancies at Rayon (secondary) level because of lack of necessary equipment and experience of medical staff. Thus, high number of women who should have been referred to oblast level in advance deliver at rayon level which endangers mother and newborn. On the other side, to prevent possible complications during delivery some women are unnecessarily referred from secondary level to tertiary level which does not have the capacities to manage a high number of cases. In addition, dealing with deliveries at tertiary level if there is no clinical indication is also a big cost-driver. European countries have identified the necessity for an advanced medical birth register to monitor and manage maternal and perinatal health either at regionalor at National level and introduced relevant electronic databases [6]. To date, such tools are with a few exceptions not available in Ukraine. On this account, the Volyn Oblast healthcare administration with the assistance of Ukrainian-Swiss Mother and Child Health Programme has taken steps towards the implementation of an Oblast perinatal registry to improve monitoring and high risk pregnant women management in Volyn Oblast. The approach is in line with the project's objectives to enforce quality assurance and to contribute to a reduction in perinatal mortality and morbidity. As the earlier development of the regional telemedicine network of Oblast and Rayon health institutions [7] this application is part of the Programm's initiative to promote and introduce open source eHealth tools in Ukraine. 2. MATERIALS AND METHODS To define the specific system requirements from both the technical and the clinical point of view an expert working group at Oblast level which included ten specialists in Mother and Child health filed from Oblast and Rayon health institutions was founded. In several meetings between June 2009 and September 2010 the working group members have developed special forms for data entry as well as identified risk factors for further integration into the application. Essential requirements to the system were: • Data unification has to be provided by using ICD-10 codes and clearly identified risk factors. Relevant data can originate from obstetrical anamnesis, woman's diseases, complication of pregnancy, abnormal results of screening tests, but also from life styles, health-related behavior, and the social environment • Hence, data has to be collected by the health professionals during the entire cycle of a pregnancy decentralized in the Rayon and Oblast health institutions. At the same time, relevant and aggregated data must be made available for data analysis, evaluation, statistics and alert functions in real-time. Oblast experts and responsible specialists shall be in charge of monitoring and consultation of risk pregnancies and make correct decision in time at Oblast or Rayon level in order to improve clinical care and patient outcome. • Security and data privacy has to be ensured with best technical measure to comply with the legislation. Different access levels for the users of the system have to be implemented to prevent possible malpractice. • It must be possible to link the perinatal registry to the telemedicine platform iPath [7] which allows easily transferring clinical cases of interest to an expert group which will provide clinical consultation services. According to the requirements, the perinatal registry was designed and developed by Ukrainian programmers in close collaboration with the specialists from Swiss Tropical and Public Health Institute, Basel, Switzerland within Ukrainian-Swiss Mother and Child Health Programme. The joint development over distance was facilitated by frequent communication and the use of a software versioning and a revision control system (SVN). The application was build using the popular programming language "PHP" together with the open source database system "mySQL". In order to save development time, "Code Charge Studio" a so called Fourth-generation programming language was used which helped in creating the graphical user interface (GUI). 3. RESULTS Due to the nature of the system, the registry was developed as web-based software – an application which is accessed over a network such as the Internet or an intranet. The PHP/mySQL architecture was chosen because it is open source, free of charge and is very suitable for multilingual database applications. The developed software product itself is also open source and freely available on the internet 1 . This was done to maintain flexibility in sense of possible future adaptations to local requirements or translations into further languages. The database structure of perinatal registry was crucial. In order to assure maximal flexibly for analysis or options to extend the data, the design follows the principles of a "relational database". This design which is often used in medical records [8] consists of a series of unordered tables and matches data by using common characteristics. Database structure of perinatal registry is shown in Figure 1. Figure 1: Database structure of Perinatal Registry of Volyn Oblast The graphical user interface (GUI) is essentially a web-site which can be accessed through a standard web-browser (see Figure 2). The system allocates access rights (Oblast-, Rayon-level or individual Institution-level) according to the user rights. After passing authentication in a log-in window, the web-based GUI allows the user to enter, edit, search or view the requested information in the perinatal registry. Data entry is mainly done through text fields, drop-down menus, and check boxes, for example lists of conditions in IDC-10 coding, list of other risk factors, list of Rayons, etc. Structured data is the key to good analysis. The main focus is on risk group pregnancies which can be identified by checking various indicators across the database and summarized in a risk report. Other statistical reports for a specific Rayon or for the whole Oblast, such as number of pregnancies, number of newborns, number of pregnant women referred to tertiary level, number and causes of deaths, number and types of pathologies, etc. can be produced at any time with no additional effort. In the future it is planned to implement MOH Reporting form #21 which will help to generate and submit reports for the health specialists. The system requirements at the client side are very low: The client computer does not need additional software installation. A standard web-browser (MS Internet Explorer > 7.0 , Mozilla Firefox > 3.0 or Opera > 9) with usual updates and plug-in is sufficient. As the software will handle patient data, strict security measures have to be implemented. Strong authentication and privileges management, as well as the use of encryption for data transfer (TLS/SSL) and storage will be in place. Another concern will be on the infrastructure in which the application will be deployed: The dedicated application server will run Linux operating system and 1 http://sourceforge.net/projects/mch-registry/ Test n Pregnancy n Antenatal visit n PATIENT


A study was undertaken to understand the changes in biochemical constituents like total protein content in twotolerant entries (MAC 3 and LMA) and two susceptible groups (DB and HA 3) of field bean against pod borers namely H. armigera and A. atkinsoni. The total protein content was lower in the tolerant group than in the susceptible entries. MAC 3 recorded the lowest (18.1, 21.2 and 23.7%), while HA 3 recorded the highest protein content (20.3, 23.1 & 26.5%) in leaves. podsand seeds, respectively. The mean total protein content was 19.33, 22.08 and 25.05 per cent in leaves, pods and seeds, respectively.


The authors present a framework for a geographic information systems (GIS)–based decision support system (DSS) designed to provide online routing instructions in response to updated information on traffic and weather conditions for vehicles transporting hazardous materials. Embedded within the DSS is a heuristic that exploits a spatially and temporally rolling horizon. The heuristic is implemented using standard, widely available tools to facilitate adoption by decision makers. The DSS's ability to dynamically update instructions in response to real-time information is demonstrated along the corridor between the metropolitan areas of Washington, D.C., and Baltimore, Maryland.


The article examines various theoretical points of view and concepts that exist in the modern literature on the problem of conceptualization of mergers and acquisitions (M&A) in the aspect of innovation. The purpose of the article is to characterize the phenomenon of mergers and acquisitions by studying how the literature describes the convergence between M&A and innovation at various levels of management, as well as to identify areas for future research developments. A systematic review of the available scientific literature revealed a limited but rapidly growing coverage of this phenomenon by scientific research, which mainly focused on several aspects (primarily, the causes of M&A, the consequences of M & A for the innovative development of the organization), often studied in isolation. This fact requires further research efforts to expand the scope of research on the convergence of M&A and innovation, and to develop frameworks and models to support effective management decision-making.


Introduction: Medicinal plants are very rich in bioactive source of drugs of traditional system of medicine, modern medicines, nutraceuticals, food supplements, folk medicines, pharmaceutical intermediates and chemical entities for synthetic drugs. E. heterophylla is widely used in folklore medicine for the treatment of several bacterial infections. In traditional system of medicine, aqueous extract or decoction of the leaves that is used to prepare food such as yam porridge or taken directly to "wash out the bowels" or as a purgative. Objective: To qualitatively and quantitatively determine the phytochemical and essential oil composition of the aerial parts of E. heterophylla. Methodology: Phytochemical and essential oil screening and quantification of the aerial parts of E. heterophylla were carried out using high performance liquid chromatography (HPLC) and gas chromatography (GC). Results: Phytochemicals characterized include 719.19mg/100g alkaloid (euphorbin-A and C), 376.20mg/100g flavonoid (quercitrin and myricitrin ), 139.80mg/100g saponin (sapogenin, and saponine), 80.60mg/100g glycoside (rutin and kaempferol-3-glucopyranoside), 33.93 sterol (sistosterol and campesterol), 25.32 phenolic acid (vanillic and protocatechuric acid), 19.32mg/100g isoflavan (daidzein and genistein), 6.11mg/100g anthocyanins (Cyaniding3-(6,6'caffeonyl-p-hydroxybenzoylso and cyaniding-3-(6,6'dicaffeonylsophoroside)-5-glucos), 1.92mg/100g terpenoid (B-amyrin and clovandiol), 1.19mg/100g anthraquinones (2,3-dimethoxybenzoquinone and heterophylline), 1.72x10mg/100g lignan (seroisolariciresino and epipinoresinol) in decreasing order and 100% essential oil. Conclusion: The presence of these essential oil and phytochemical constituents in E. heterophylla could be responsible for the therapeutic activities elicited by the plant.


This study aimed to determine the degree of incidence of alexithymia in addicts and non-addicts according to the cut-off score, and the differences between the two samples on the dimensions of the used scale by the sub and the total scores. It also aimed to determine the effects of age and the level of education on the incidence of alexithymia. A sample of 589 males in Kuwait, (264 addicts and 325 non-addicts), completed the 20-item Toronto Alexithymia Scale (TAS-20). The result showed significant higher score mean of incidence of alexithymia and probability of developing it in the sample of addicts. Moreover, it found significant differences in the sub-dimensions and the total score in favor of the addicts. The analysis of variance ANOVA did not reveal differences between age and educational level in the sample of addicts, While in the non-addicted sample there were significant differences in age. It was found that the level of alexithymia decreased with age, in the total score and Difficulty Identifying Feeling, Difficulty Describing Feelings subscale, And Externally-Oriented Thinking subscale, and that the higher the academic qualification decreased the level of alexithymia..


The invention relates to a partitioned power supply method considering industrial city load characteristics and belongs to the technical field of electric power system planning and reliability evaluation. According to the technical scheme, a typical partitioned power network structure reliability set is formed, and all partitions are subjected to rapid reliability evaluation; a short circuit current out-of-limit point is found out, and partition schemes are made according to a short circuit current distribution and partition unlinking decision function; the schemes meeting the requirement for the short circuit current level are subjected to safety and stability evaluation and reliability evaluation to obtain an optimal solution of a reliability-short circuit current objective function; according to the industrial load level of all the partitions, the reliability of weak partitions is improved, and a final partition scheme is output. According to the partitioned power supply method, a rapid reliability evaluation model for partitioned power supply schemes is established through a typical partition structure, the influence of an industrial load on the reliability of all the partitions is analyzed, and corresponding improving measures are proposed according to the reliability level; the partitioned power supply method can be applied to industrial city partition schemes, and the evaluation and optimization method has universal applicability.


For most of my academic career, I have depended on national organizations to give me the kind of support network I need in my chosen areas of study, African American, ethnic, and Southern literature. This has turned me into a kind of conference junkie; I recently attended my 22nd MLA in a row! However, for many years the MLA was void of the kinds of panels I needed; for that reason, and many others, the organization that has always meant most to me is MELUS, the Society for the Study of the Multi-Ethnic Literature of the United States. MELUS, in fact, eventually drew me to MLA, since this became the site where we convened executive committee meetings, enjoyed cocktail parties and banquets, and most importantly, presented our work to each other and the broader constituency of the MLA. MELUS, of course, is probably familiar to people reading this, but let me briefly relate the fabled story of the organization's origin. As Katharine Newman herself has recorded, the year was 1972, the setting, the MLA annual convention. A group of angry scholars of ethnic literature, who had many times tried and failed to get the MLA to accept a panel on African American literature, organized an impromptu session in the hallway of the headquarters hotel (99-100). Out of that frustration, rebellion, and commitment, MELUS was born: the original band of insurgents decided that they would foster a society dedicated to all the ethnic writers of our country. The organization was sustained, however, not by anger, but by the joy of discovery, fellowship, and a vital sense of mission. MELUS's goals were always clear: find and connect the scholars of ethnic American literature; encourage the development of a new literary history; and make that literary history live by locating, annotating, publishing, and discussing both "lost" and new literary texts. Eventually, even the MLA recognized MELUS and gave the organization regular sessions at the annual conference. Subsequently, MLA started sponsoring divisions and sessions on all the varieties of ethnic literature, as MELUS types began to infiltrate the hierarchy, and as more ethnic Americans were admitted into the academy itself and then began to demand their literatures be respected and studied. MELUS deserves kudos for its role in this revolution, but the organization got most of its reputation from its outstanding journal, which has today become one of the leading venues for discussions of ethnic literature, culture, and theory. The now-legendary "Mother MELUS," Katharine Newman, one of the original insurgents, became the founding and long-time editor of our journal. For many years, both the journal and MELUS itself were respectively the leading journal and umbrella organization for Asian American Studies, Jewish literary studies, and several other clusters of scholars, many of whom have now gone on to organize societies dedicated to their specialties. From the first, then, MELUS was evangelical, and none of our original motives have really changed. We tell prospective members, "We don't just want your dues--we want YOU!" One of the great benefits of our annual convention has been the invigorating influx of new, often young, talent, and the conferences have always attracted scholars from abroad, who until recently were often doing their work on ethnic writers in isolation. We also have "set our text" at ALA, ASA, and at regional MLAs. More importantly, for the past eighteen years, MELUS has sponsored its own conference in the spring; these events have taken place all over the United States, at campuses such as the University of Minnesota, UCLA, Howard, Hawaii, Vanderbilt, and Berkeley. Even in its infancy, MELUS drew the attention of devotees of American ethnic literature across the globe, particularly in Europe, where American studies programs had often seen the significance of American ethnic culture long before their counterparts in the States. Our conferences drew increasing numbers of European scholars, and eventually trans-Atlantic conversations developed about a European chapter. …


The present invention discloses pharmaceutical preparations for treatment of eye disorders containing an alpha 2 adrenergic agonist, to processes for producing the pharmaceutical preparations and methods for treatment of various eye disorders including dry eye and meibomian gland dysfunction and a medicinal applicator for topical application of an alpha 2 adrenergic agonist to a subject, a package assembly for the medicinal applicator and methods of using the medicinal applicator to treat eye disorders.


Damage of materials inherently involves coupling of deformation and failure mechanisms at multiple length and time scales. This paper develops self-consistent elastic constitutive relations of crystalline materials containing atomistic scale cracks, from observations made in a concurrent multi-scale simulation system coupling atomistic and continuum domain models. The self-consistent constitutive model incorporates both nonlinearity and nonlocality to account for atomic level interactions and deformation mechanisms, especially near crack tips. Atomistic modeling in the concurrent model is done using molecular dynamics (MD), while the continuum modeling is done using a crystal elasticity finite element (FE) analysis code. The atomistic–continuum coupling is achieved by enforcing geometric compatibility and force equilibrium in an interface region. The constitutive model is calibrated by comparing with the results of MD predictions in the concurrent model. For validation, the crack tip stress field is investigated using both the coupled concurrent model and a FE model with the constitutive law. The self-consistent model exhibits excellent accuracy and enhanced efficiency in comparison with pure MD and concurrent model results.


The invention relates to a preparation method of high-purity rizatriptan benzoate. The preparation method comprises the following steps: (1) carrying out diazotization, namely reacting 4-(1H-1,4-triazole-1-methyl)aniline with a sodium nitrite water solution to generate diazonium salt; (2) carrying out nitrogen reduction and hydrazine reaction, namely carrying out nitrogen reduction on the diazonium salt by virtue of the sodium nitrite water solution to generate 1-(4-hydrazinophenyl)methyl-1,2,4-triazole by virtue of concentrated sulfuric acid; (3) carrying out indole reaction, namely carrying out indole reaction on 1-(4-hydrazinophenyl)methyl-1,2,4-triazole and 4-dimethylamine butyraldehyde dimethyl acetal to generate rizatriptan alkali; and (4) carrying out salt forming reaction: namely forming salt from rizatriptan alkali and benzoic acid. According to the preparation method of the high-purity rizatriptan benzoate, the percentage of impurities is smaller than 0.5%, and the percentage of any simple impurity is smaller than 0.1%; meanwhile, the preparation method has the advantages that the yield is high, raw materials are easily available, the reaction condition is mild and safe, special equipment is not required, and the cost is lowed; the preparation method is high in total yield and applicable to industrial production.


New phase transitions at 462 and 495 K have been found in Ba(NO2)2. The increase in entropy at each transition is about 13 J mol−1 K−1. A gain of two orientations per independent NO−2 ion at each transition corresponds to an entropy increase of 11.5 J mol−1 K−1. The crystal melts at 516 K. The high‐temperature phase I is metastably retained at 298 K on rapid solidification, reverting to phase III on reheating above 350 K. Phase III is orthorhombic with lattice constants at 298 K of a = 7.657, b = 8.355, and c = 6.742 A and four Ba(NO2)2 in the unit cell. The linear thermal expansion coefficients are 30.7, 14.0, and −5.9×10−6 A K−1 for the a, b, and c axes, respectively. The powder pattern for phase II has not been indexed. Phase I may be fitted by a monoclinic unit cell with a = 6.692, b = 7.052, and c = 9.638 A and β = 104.61° at 507 K with four Ba(NO2)2 in the unit cell. A dielectric anomaly is observed at 468 K in the frequency range 0.1–1 MHz: dielectric losses obscure the anomaly at lower frequencies.


Objective:To investigate the role of NF-KB/lKB signal pathway in the regulation of proinflammatory cytokines in Ang II-induced human mesangial cells (HMC) . Methods: TNF-a, IL-la and IL-lp mRNA expression was determined by ribonuclease protection assay. Electrophoretic mobility shift assay (EMSA) and Western Blot were used to detect the activity of NF-kB and degradation of 1KB. Results: HMC incubated in medium alone did not express IL-la mRNA, but there was constitutive mRNA expression TNFa and IL-1b in unstimulated cells. Ang II significantly upregulated TNF-a, IL-1a and IL-1b mRNA expression. Significant up-regulation of NF-KB activation, nuclear translocation of p65 subunit, and degradation of IkBa and IkBb were observed in Ang II-induced HMC. Conclusions: Expression of proinflammatory cytokines in Ang Il-induce HMC was mediated by NF-KB/lKB signal pathway.


In this study, a survey was conducted on the customers who had visited Korean restaurants in Daejeon from October 1st to October 30th of 2011 for empirical analysis to clarify the difference in Selection attributes and behavioral intention for Korean restaurants by motivation for Eating out. There search was executed by self-answering subjective method and 259 copies, out of 300 copies deployed then 275 collected from which inappropriate ones were removed, were used to run factor analysis for explaining the dimensions and correlation of selecting properties and them motivation by SPSS Win Ver, 17.0 statistical package. In addition, multivariate analysis of variance(MANOVA) was performed for thesis verification and cluster analysis on motivation to eat out. In summary of the analysis, factors in Selection attributes were found to have differences dependent on the motivation type to eat out and the motivation was statistically shown to give a significant difference in behavioral intention. Based on the results, useful implications were suggested.


One as "the hundred problem years of after the W. colorirne"1 E. B. Du Bois that identified problem America's appears as greatest intransigent challenge as as "the problem of the col rirne"1 at problem appears as intran igent as ever. Although many members of our society wish it away or deny its continued relevance, racial inequality and antagonism are alive and well, as attested most recently by the controversy over African American voter access in Florida in the 2000 presidential election and by the recent lawsuits seeking reparations for slaves' descendents.2 Accusations of white racism or black "reverse racism" fly freely in the Land of the Free, and affirmative action for equal opportunity generates heated debates in this nation dedicated to the proposition that "all men are created equal." As sociologist Orlando Patterson puts it, discussions about race in the United States today resemble a "dialogue of the deaf."3 Tragically, it appears that the present generation is destined to pass on the problem of race to still another generation. Yet this generation also bears another legacy from the twentieth century one that emerged only in its final decade: an international trend toward interethnic and interracial reconciliation. Since the early 1990s, political and religious entities in South Africa, Australia, Ireland, and other nations have taken significant steps to overcome long-intractable conflicts between ethnic and racial groups in their societies. These initiatives have included such measures as public confession, apology, forgiveness, and, in some cases, attempts at reparation. In his recent and groundbreaking work Interracial Justice , Eric K. Yamamoto observes that "race apologies among groups apparently trying to restore broken relationships exploded as a worldwide phenome-


The chosen steroid hormones are the human sexual hormones. Estradiol and estriol are femail hormones (estrogens), testosterone is male hormone (androgen). The greatest difference in structure of these molecules is observed in the A-ring which in an estrogen molecule is aromatic and planar while in an androgen molecule the A-ring has a distorted 1a-sofa conformation (Fig. 1). The estrogen molecule also is characterized by absence of angular methyl group in ?10-position. DFT calculations are shown that these molecules contain vibration modes in terahertz range connected by deformations of all steroid rings and by the COH and methyl-group twisting [5]. The analysis of vibration spectra indicates that there are some interesting correlations between molecular structure and spectral properties. The THz absorption spectrum of testosterone has intensive absorption maxima at 48(v<inf>2</inf>) and 81(v<inf>5</inf>) cm−1 (Fig.1). Raman spectrum of testosterone has several absorption maxima at 28, 37(v<inf>1</inf>), 44(v<inf>2</inf>) and 58(<inf>3</inf>) cm−1. Vibration modes v<inf>1</inf>, v<inf>2</inf>, v<inf>3</inf> and v<inf>5</inf> are determined by deformation of all steroid rings and also are visible in estrogen spectra (Fig. 2). The structures of testosterone and estradiol differ only the A-ring conformation and vibration mode v<inf>2</inf> is more intensive in testosterone.


We focus on the distribution regression problem (DRP): we regress from probability measures to Hilbert-space valued outputs, where the input distributions are only available through samples (this is the 'two-stage sampled' setting). Several important statistical and machine learning problems can be phrased within this framework including point estimation tasks without analytical solution (such as entropy estimation), or multi-instance learning. However, due to the two-stage sampled nature of the problem, the theoretical analysis becomes quite challenging: to the best of our knowledge the only existing method with performance guarantees to solve the DRP task requires density estimation (which often performs poorly in practise) and the distributions to be defined on a compact Euclidean domain. We present a simple, analytically tractable alternative to solve the DRP task: we embed the distributions to a reproducing kernel Hilbert space and perform ridge regression from the embedded distributions to the outputs. We prove that this scheme is consistent under mild conditions, and construct explicit finite sample bounds on its excess risk as a function of the sample numbers and the problem difficulty, which hold with high probability. Specifically, we establish the consistency of set kernels in regression, which was a 15-year-old-open question, and also present new kernels on embedded distributions. The practical efficiency of the studied technique is illustrated in supervised entropy learning and aerosol prediction using multispectral satellite images.


The interaction between impeller and volute produces a complex and unsteady water flow. It involves the interference of the non-uniform flow (such as the impeller's jet wake and a secondary flow). In this paper, the transient flow in a new type of dishwasher pump is investigated numerically. In addition, pressure measurements are used to validate the numerical method, and the simulation results agree well with the experiment. Three schemes, 0 rpm (revolutions per minute)/30 rpm/60 rpm, of volute speeds are investigated. Multiple monitoring points are set at different positions of the new dishwasher pump to record pressure-pulse signals. In addition, frequency signals are obtained using a Fast Fourier Transform, which is then used to analyze the effect of the volute tongue and the outflow of the impeller. The radial force on the principal axis is recorded, and the schemes with different rotation speeds of volute are compared. The results show that the volute speed has only a small effect on the pump performance. In addition, the speed of the volute mainly affects the flow field in the transition section located between impeller and volute. The difference of the flow field in the impeller depends on the relative position between the impeller and the volute. The time domain curve for the pressure pulse is periodic, and there is a deviation between the peak for the schemes in the outflow region. In the frequency domain, the characteristic frequency equals the blade passing frequency. In the outflow region, the effect of the volute speeds increases with increasing volute speed. For the radial force, the rotating volute strengthens the fluctuation of the radial force, which affects the operational stability of the pump. The shape of the vector distribution is most regular for the 30 rpm scheme, which indicates that the stability of the pump is the highest. This paper can be used to improve both the control and selection of volute speeds.


Objective
To explore the change of serum cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and carbohydrate antigen 125 (CA125) levels before and after neoadjuvant chemotherapy in patients with breast cancer and their relationship with the efficacy.

Methods
Totally 80 breast cancer patients in the Fifth People's Hospital of Qinghai Province from March 2015 to March 2018 were enrolled for a retrospective study. All patients were treated with neoadjuvant chemotherapy of docetaxel+ adriamycin+ cyclophosphamide (TAC) regimen. The serum CYFRA21-1 and CA125 levels were detected by the enzyme-linked immunosorbent assay. The relationship between serum CYFRA21-1 and CA125 levels and the efficacy of neoadjuvant chemotherapy was analyzed. The independent sample t test was used for comparison between groups. The paired t test was used for the comparison before and after treatment in the same group. The receiver operating characteristic(ROC) curve was used to analyze the predictive value of different methods (CYFRA21-1, CA125, CYFRA21-1 combined with CA125) in evaluating the efficacy of chemotherapy.

Results
The serum levels of CYFRA21-1 and CA125 in patients with breast cancer after chemotherapy were significantly lower than those before chemotherapy [(4.51±0.53) ng/ml vs (4.95±0.65) ng/ml, t=4.692, P 10%), 72.22%(26/36), 77.27%(34/44), 75.00%(60/80)and 0.758 for CA125 (critical value: the reduction ratio >12%), 94.44%(34/36), 95.45%(42/44), 95.00%(76/80) and 0.906 for the combination of both factors. The accuracy and area under the curve in combination of both were significantly higher than those when either factor was used (all P <0.017).

Conclusion
The changes of serum CYFRA21-1 and CA125 levels in breast cancer patients before and after neoadjuvant chemotherapy are related to the efficacy of neoadjuvant chemotherapy, so CYFRA21-1 and CA125 can be used as indicators for efficacy evaluation, and the combination of both may have a better predictive value.

Key words:
Breast neoplasms; Chemotherapy, adjuvant; Antigen; Treatment outcome