A comparative study of classic and modern time-domain nonlinear modeling techniques is presented for the case of loudspeakers. NARMAX modeling, as well as some modern methods, employing artificial neural networks, fuzzy logic, and their combinations, are applied using measured time-series input-output data. The comparison is performed on the basis of their ability to produce accurate but also adequate and parsimonious nonlinear loudspeaker models, as well as of the simplicity of their application. Both stationary random and real musical signals are used in the evaluations.


Soil is a vital resource for survival for many rural populations. However, soil erosion negates the ecosystem function, productivity, livelihoods and national economy. To enable sustainable functioning of the ecosystem, it necessitates a need for proper management. There is a need for understanding socio-economic dynamics in soil erosion management. Therefore, this study sought to test the hypothesis that socio-economic factors significantly influence the participation of farm households in management of soil erosion in Chepareria Ward, West Pokot County. The study was anchored within the Diffusion of Innovation and Social-ecological System theory which supports social and economic capital assessments underlying individual decision in con serration plans to attain sustainable co system services. A household survey was undertaken and a total of 100 households were sampled. Data was analyzed in descriptive and binary logit regression model using the SPSS software. The results obtained indicate that age, education level of the respondent, cost of technology and land acreage were the possible predictor factors that showed significant influence at p<0.05 level of significance, hence supports the hypothesis tested. The study findings and recommend at ions will immensely help the land use planners and policy makers to encourage community participationandexecutesitesustainablemanagementpracticestoimprove ecosystem functioning at national and local environment thus improving participation of rural community as the primary stakeholder and achievement of sustainable development on natural resource management.


Measurements of the diffuse flux and the Crab Pulsar NP 0532 are updated. Special attention is given to the energy spectrum of these two phenomena.


This study investigated the effect of the tempering before aging on the precipitation of Laves phase and mechanical properties of 10Cr-6W and 10Cr-6W-3Co ferritic heat-resistant steels. Laves phase was precipitated by aging, which increase tensile strength but decreased elongation and impact value. Toughness was rapidly decreased by the presence of the very fine disk-like Laves phase precipitated at early aging stage. Strength and impact value were decreased by tempering treatment and that is due to the increase of the particle number per unite area and to larger particle size of Laves phase. Laves phase increased by adding Co, and consequently strength was increased and elongation and toughness were decreased. (Received February 26, 2004)


SIR, The Guidelines for pre-transfusion compatibility procedures in blood transfusion laboratories (BCSH, 1996) now includes a section on recommendations for computer issue without a serological crossmatch. These recommendations concentrate on the capture and interpretation of information from patient information, but I am concerned that they do not adequately address requirements associated with the blood donation. It is essential that information on the blood donation is accurate, and that this information is transferred to the computer system carrying out the electronic selection in a secure manner. Currently most hospital blood bank systems would capture the six-digit donation number and the group by barcode reader from the pack, but in some systems the regional identifier is assumed to be that of the local blood centre or has to be manually entered. Also the pack expiry date is not always captured electronically. I have serious reservations about the suggestion that hospital laboratories could carry out confirmatory testing of donor blood grouping. Any grouping procedure carried out within the hospital will lack positive sample identification and result transfer, and will involve manual sampling and labelling. By definition this is far less secure than the systems in place at the transfusion centres. To use a confirmatory system which is considerably less secure than the original test system cannot be cost effective and will only provide a 'comfort factor' which is unjustified. I would therefore suggest that recommendation (vi), Appendix 2 of the guidelines should be modified to read:


Wearables may have notable potential as an assistive technology for persons with various difficulties. Although quite popular, smartwatches' niches are still revealing. One of them is definitely in the domain of assistive technology due to their communication and location features. Positioning features enable parents or caregivers to know the whereabouts of child or persons with disabilities, thus increasing their safety. The paper presents smartwatch tracking system for people with complex communication needs with emphasis on detection of smartwatch wearer's common movement routes. The application is a result of multidisciplinary research performed in the area of information and communication technology, as an assistive technology aiming to explore the technological possibilities of connecting new generations of mobile devices and their technological supplements, or wearables, in order to establish a different communication and location aids.


Caches are integral parts in modern computers; they leverage the memory access patterns of a program to mitigate the gap between the fast processors and slow memory components. Unfortunately, the behavior of caches can be exploited by attackers to infer the program's memory access patterns, by carrying out cache-based side-channel attacks, which can leak critical information. Secure caches that were proposed employ cache partitioning or randomized memory-to-cache mapping techniques to prevent these attacks. Such techniques may add to the complexity of cache designs. In this work, we suggest the use of specialized prefetching algorithms for the purpose of protecting from cache-based side-channel attacks. Our prefetchers can be combined with conventional set associative cache designs, are simple to employ, and require low incremental hardware overhead costs, if the base prefetching scheme is already employed. We integrated our prefetching policies with commonly used GHB and stride prefetching schemes, and compared their performance with the standard implementations of those schemes, on both conventional and secure cache designs. More specifically, our results show that the use of our secure prefetching policy delivers original prefetching performance when integrated with a stride prefetcher. Finally, we demonstrate how a disruptive prefetching scheme can protect the cache from an access based side-channel attack.


Given a single image of an indoor scene without any prior knowledge, is it possible for a computer to automatically reconstruct the structure of the scene? This letter proposes a reconstruction method, called RISSIM, to recover the 3D modelling of an indoor scene from a single image. The proposed method is composed of three steps: the estimation of vanishing points, the detection and classification of lines, and the plane mapping. To find vanishing points, a new feature descriptor, named "OCR", is defined to describe the texture orientation. With Phrase Congruency and Harris Detector, the line segments can be detected exactly, which is a prerequisite. Perspective transform is a defined as a reliable method whereby the points on the image can be represented on a 3D model. Experimental results show that the 3D structure of an indoor scene can be well reconstructed from a single image although the available depth information is limited.


Structural, electronic and electrical properties of Phosphorus doped ZnO thin films deposited using pulsed laser deposition technique, on P-type Si (111) substrate are studied. X-ray diffraction measurements shows that undoped ZnO and Phosphorus doped ZnO films oriented along c-axis and maintains wurtzite crystalline symmetry. The change in grain size occurs by Phosphorus doping, which can be correlated to stress comes due to presence of Phosphorus. The changes in electronic structure has been observed by Phosphorus doping in ZnO thin films, which is understood from X-ray absorption spectroscopy. Hall measurements shows n-type behavior of Phosphorus doped ZnO samples.Structural, electronic and electrical properties of Phosphorus doped ZnO thin films deposited using pulsed laser deposition technique, on P-type Si (111) substrate are studied. X-ray diffraction measurements shows that undoped ZnO and Phosphorus doped ZnO films oriented along c-axis and maintains wurtzite crystalline symmetry. The change in grain size occurs by Phosphorus doping, which can be correlated to stress comes due to presence of Phosphorus. The changes in electronic structure has been observed by Phosphorus doping in ZnO thin films, which is understood from X-ray absorption spectroscopy. Hall measurements shows n-type behavior of Phosphorus doped ZnO samples.


The main idea of the article is the formation of the Russian nation on the basis of the Eurasian civilization under the condition of its leadership in states where the Eurasian civilization values have effect. The Russian nation is defined as a multi-ethnic community of the citizens of Russia, formed on the basis of the Eurasian civilization. And the author poses the Russian ethnos into the core of the Russian nation. Such interpretation of the nation allows integrating ethnic nationalisms into the pan-Eurasian tradition of the national-building, making the multi-ethnicity of the state a factor of strengthening its national security.


U UNTIL recently, J. B. Say's Law of Markets has been widely accepted by economic theorists,' even though Say's contention of the impossibility of general overproduction and glutting of markets2 seemed contradicted by the recurring experiences of severe crises. The presence of general overproduction, however, so impressed Say that he felt compelled to introduce modifications of his theory, which destroyed its inner consistency.3 This he did by defining "production," not in the usual sense of physical output of goods and services but only as the production of goods of which the sales receipts cover the costs. Thus Say reduced his Law of Markets to a meaningless tautol-


The economic crisis in Indonesia was caused companies bankruptcy. Most of the companies had the finance crisis. So, improving the profitability is a must in the company to defend and develop the business.
This research was conducted to find out the influence of the total consumer (X1), length of pipeline network (X2), investment cost (X3), sale price of the oil (X4) and the US$ exchange rate (X5) in 1994 until 2003 time period by using the multiple linear regression model. And the result of the above F test is finding out that the total consumer, length of the pipeline network, investment cost, sale price of the oil and US$ Exchange rate was stimulant affected to the profitability of publicly listed state gas distribution company PT Perusahaan Gas Negara (PGN). While the determinant of the coefficient R square is 59,3%, which is the most dominant is the 77,4% total consumer. The rest are 75% sale price oil, 60,5% the length of pipeline network, 20,1% investment cost and 12,8% US$ exchange rate.
The t test was conducted to find out the influence of the total consumer, length of pipeline network and the sales price of the oil as partial influence is significant, while the investment cost and the US$ exchange rate as partial influenced is not significant to the profitability pf publicly listed gas distribution company PT Perusahaan Gas Negara (PGN).


The title of this paper is a challenge to the psychiatry of eighty to a hundred years ago and to the old materialistic medicine. At that time every mental disease was supposed to be a cerebral disease. This older point of view was particularly stressed by Griesinger, in Zurich, ninety years ago. He felt quite certain that psychoses without cerebral pathology did not exist, but there were some psychoses the cerebral pAthology of which had not been investigated as yet. If I speak of the psychiatry of cerebral diseases, and if I separate it from the psychiatry of diseases with intact cerebral structure, I have no intention of taking part in a philosophical discussion on the relation of mind and body. I approve, of course, of the modern concept of psychosomatic medicine, which considers bothstructure and function, body and mind-as equivalent and inseparable expressions of life itself. My paper, however, is not based on theoretical and controversial philosophies. It is based on the concrete and certain fact that up to the present day we have had to deal on the one side with mental diseases which have a cerebral pathology, and on the other side with mental diseases which, so far as our present knowledge goes, do not. It is also based on the conviction that for practical, diagnostic, and therapeutic reasons it is good to consider the differences of psychopathology of the mental conditions with an& without cerebral pathology. In this modest unphilosophical sense we are allowed to speak to-day of the psychiatry of cerebral diseases. Until the beginning of this century most brain pathologists were psychopathologists, and the reverse was equally true. Since then increasing specialization in medicine has gone far in separating brain pathology and psychopathology. The progress of our knowledge in regard to the correlation between psychopathology and brain pathology has been hindered to a regrettable extent as a result of this separation. We must become conscious of the fact that modern medicine is in need of better and more detailed knowledge of the psychiatry of cerebral diseases. It is handicapped in its progress by the neglect of this discipline by two generations of psychiatrists.


In the desire to reform the penal system, separate countries of the Commonwealth of Independent States have made significant progress, substantially updating their legal framework. These also include the Republic of Kazakhstan. The study of the normative consolidation and organization of educational work with convicts under the Kazakhstan and Russian legislation and a questionnaire of practitioners revealed the advantages and disadvantages of regulatory support and law enforcement practice. This made it possible to outline further ways to improve the legal regulation of educational work with convicts in the direction of convergence with international standards. The penal legislation of the two countries largely coincides, but in Kazakhstan the issues of educational work find their legal consolidation not only at the level of the Penal code, but also in special acts. The advantages of Kazakhstan's legislation include: a clear definition of the tasks, directions, forms and methods of educational work; improvement of the mechanism of incentives and penalties application; determining the degree of behavior of convicts; involvement of the Probation Service in the provision of social and legal assistance to convicts preparing for the release; the presence of convicts among the subjects of educational work of voluntary organizations. Otherwise, the organization and conduct of educational work with convicts coincide. The basis of the organizational structure of the correctional institution is the unit, the heads of which are overloaded with the tasks not directly related to the implementation of the correctional process. Taking into account the experience of the Republic of Kazakhstan, it is proposed to amend the Penal code of the Russian Federation, in terms of the formulation of the concept of educational work through its tasks; clarification of norms relating to the directions, forms and methods of educational work. In the Provision about the units of prisoners in correctional institution, it is necessary to change the amount of duties for the head of the unit: establishing a ban (limitation) on the involvement of chiefs to implement unusual functions for them; the transfer to the category of rights the obligation to participate in inspections of the presence of persons held in a correctional institution, taking them to work (from work), their presence during searches, mealtime in the dining room, getting of parcels, transfer, sale of food and basic necessities, telephone conversations.


LICHEN simplex chronicus, the subject of this paper, is, in our experience, quite common among private patients and should be of some interest to radiologists. It is almost always associated with a great irritability, and highly nervous state of the patient. The high-tension, present-day living conditions offer a suitable soil and predisposition to the lesion. It seems that since the war the number of cases of lichen simplex chronicus in our practice has greatly increased. The nosology of the disease is difficult for it has no special demonstrable anatomical connection with the nervous system nor is it a typical lichen; on the contrary, it is classified as a pseudo-lichen. Indeed, some specialists deny the entity of the disease altogether, claiming that it is nothing more nor less than a chronic eczema. At present, however, the younger medical minds are changing, and falling in line with Vidal and Brocq, of the French school, who were first to describe the disease twenty years ago. Jadassohn, of the Germa...


Adsorption of glycine on amorphous calcium phosphate and its thermal stability were investigated by the reactions in an aqueous solution of CaCl2-K2HPO4-C2H5O2N-KOH system. Characterization of the products was determined by means of X-ray diffraction, thermal analysis (TG-DTA), infrared absorption spectrometry and ion chromatography. The largest quantity of glycine adsorbed on amorphous calcium phosphate having Ca/P atomic ratio of 1.65 was 8.5 mass% when it is synthesized under the conditions of temperature at 0•Ž, initial pH 10.0 and C2H5O2N /CaCl2 molar ratio 11.0, and then aged at 40•Ž. It was proved that the glycine as one of the amino acids was more tightly adsorbed on the surface of amorphous calcium phosphate than on HAp. The glycine adsorbed on amorphous calcium phosphate was started decomposition at above 200•Ž, was finished at 600•Ž, and amorphous calcium phosphate was then transformed to α -type tricalcium phosphate at around 660 °C.


This April 2021 issue of the Journal of Mixed Methods Research (JMMR) includes an editorial for a new virtual special issue, six articles and one media review. In the editorial, Fabregues, Molina-Azorin and Fetters (2021) introduce the third virtual special issue of JMMR. A virtual special issue is an online-only collection of previously published JMMR articles about an important topic in the field of mixed methods research. The first two virtual special issues focused on paradigms (Molina-Azorin & Fetters, 2020) and integration (Guetterman, Molina-Azorin and Fetters, 2020). In this third virtual special issue, five editorials and eight articles have been selected regarding another important topic: quality in mixed methods research. All three virtual special issues can be seen in the JMMR webpage under the ''Collections'' section. (https://journals.sagepub.com/home/mmr). In the first article of this issue, Akerblad et al. (2021) with affiliations in social sciences and philosophy, have introduced the concept of integrative strategy. This constitutes the efforts that researchers make to carry out a mixed methods research process where they are aware of and explicate the choices concerning the relationship between foundations (methodological-philosophical justifications) and praxis (practical processes of the research, the ''doings'' during the research process in a study). The authors' methodological purpose was to appraise the concept of integrative strategy and to identify how different types of integrative strategies can inform discussions and practices regarding integration in mixed methods research. Moreover, the authors examined specific perspectives on integration and analyzed three mixed methods studies as cases in order to examine and compare research practices concerning integration, and identify integrative strategies in each case.


When the U.S. military's railroad agency constructed an official railcar for the newly reelected Abraham Lincoln, agency officials never imagined that they had built his hearse. The car, completed in early 1865, was the Air Force One of its day. But the 16th president did not live to ride in it. Instead, the car, draped in bunting, carried his coffin on a 12-day funeral procession from Washington, D.C., to Springfield, Ill. Mourners flocked trackside to catch a glimpse of the assassinated leader. Newspapers ran front-page stories. Yet even with all those accounts, scholars are fuzzy on a few important details about the car, such as what color it was painted during an era that predated color photography. Now, a chemist and a conservator think they have solved that mystery. An outside expert, however, would like to see results from a few more tests before declaring the case closed. The question ...


The paper begins with a review of the concept of neoplastic progressions in plant tissue cultures, with the progressive acquisition of (a relative) independence to the
hormones auxins and cytokinins. It takes advantage of the deviations of carbon and nitrogen metabolisms shown in these particular cases, to illustrate the interdependence
with the metabolisms of the hormones ( and increased sensitivities to) polyamines and ethylene. These results provide additional examples of the changing concepts in
hormonology.


In recent years, technologies are being developed to treat acid mine drainage ( AMD ) , rock drainage (ARD ) and other effluents which are causing environmental pollution, both in water and soil . International environmental regulations today are quite demanding , since the current priority is the preservation of the environment. Currently has been developing terminology SBR SECUENTIAL BATCH REACTOR describing a group of variable volume systems for activated sludge treatment , where the processes of sedimentation, aeration and clarification are performed in the same reactor. In the SBR happen sequentially in time different processes of equalization, aeration and clarification. This added to the biomass technology allows treatment of a wide range of metallic and organic compounds . SBR is successfully applied in USA and CANADA hundreds of industrial plants. In this context we construct the pilot effluent treatments , incorporating modern technologies for the remediation of effluents from metallurgical plants , for it had to resort to the techniques of plant design plant, and we used software design teams and prototypes; as well as environmental considerations of clean technologies .


We introduce the pinching operator, which extends the theory of squeezing operators to cubic and higher order non-Gaussian operators, and use it to approximate $n$-photon entangled states using a pinched vacuum state and pinching tensor of rank $n$. A simple recursion relation is derived for generating the Bogoliubov transformed creation and annihilation operators, which may be used to express the pinched state as a statistically equivalent set of nonlinearly transformed complex Gaussian random variables. Using this representation, we compare low-order approximations of the pinched state to entangled multiphoton Fock states, such as Greenberger-Horne-Zeilinger (GHZ) and W states. Using post-selection and a threshold detector model to represent non-Gaussian measurements, we find that this model is capable of producing states with a fidelity comparable to that of experimentally prepared multiphoton entangled states. In particular, we obtain a Mermin statistic of $5.27 \pm 0.01$ for a five-photon GHZ state, violating the noncontexuality threshold by 127 standard deviations.


Modeling and control of bidirectional dual active bridge DC–DC converter becomes an important issue as they are extensively used in electric vehicle applications. This work deals with design and si...


In historical retrospect, the use of national issues and contradictions has repeatedly become the weakening mechanisms for some great powers in regard to others. In this case, various technologies to construct national myths and ideologies based on tribalism and national exclusiveness and superiority were applied. After the "Crimean spring" in 2014, the Crimean Tatar issue gained a new level of relevance. The Republic of Türkiye and Ukraine are actively using the Crimean Tatar factor to oppose the reintegration of Crimea into the Russian Federation and, consequently, to weaken Russia's positions in the Black Sea and Mediterranean region. In the article the authors analyze the peculiarities of the influence of the Republic of Türkiye on the Crimean Tatars, as well as the Ukrainian initiatives in relation to the Crimean Tatars and joint Turkish-Ukrainian projects, with the target group consisting of the Crimean Tatars. The methodological basis of the research is system-based, geopolitical, civilizational and institutional approaches, which are implemented both directly and by using a number of general scientific and political science methods. The current policy of Türkiye and Ukraine on the Crimean Tatar issue has common features. Firstly, it is currently topical for the policy elites of these states, both at the domestic and international political levels. Under these circumstances, if the Crimean Tatar issue is an opportunity for Kiev to re-establish its jurisdiction over Crimea, then for Ankara the Crimean Tatar population helps to enlist the electoral support, as well as to consider Crimea and the Black Sea region as a Turkish sphere of influence. Secondly, the conditional Turkish-Ukrainian alliance presents itself as a "protector" of the Crimean Tatars from "Russian aggression." Thirdly, Türkiye and Ukraine are projecting a positive state image by demonstrating protection of interests and observance of the Crimean Tatars rights on the territory of Russia. Fourthly, the actions of Türkiye and Ukraine in terms of the Crimean Tatar can be characterized as a double standard policy. This thesis is confirmed by the national policy of the Republic of Türkiye, and the approaches of Ukraine to the solution of the Crimean Tatar issue before the reunification of Crimea with Russia.


Job analysis is needed to analyze and design what work to do, how to do it, and why the work should be done. Job analysis will provide information about job descriptions, job specifications, and job evaluations and can even predict job enrichment or expansion and job simplification in the future. This study aims to implement database security management procedures as a measure to prevent damage (error), loss and theft of data through backup and restore methods accompanied by encryption in the Job Analysis System application of the Balangan Regency Organization Division (Simanja). The backup process by adding Advanced Encryption Standard (AES) encryption which is stored to remote cloud hosting as a backup server using SSH Transfer Protocol (SFTP) provides adequate and efficient security.


ANNALS, AAPSS, 628, March 2010 I by some quirk or device—such as a time machine, capsule, or tunnel—we were transported back to 1998, a dozen years before this volume was produced, we would be thinking about field experiments in political science in a very different way than we do now. Although some early experiments had been conducted in field settings, by the 1980s, students of political behavior had largely abandoned them in favor of the analysis of large-scale surveys. Not a single field experiment was published in any political science journal in the decade preceding 1998, when field experimentation began to make a comeback. The first voting experiments, examining the impact of mail, telephoning, and canvassing on turnout, had been conducted but not yet published (Gerber and Green 2000). The next wave of field experiments in political science was just about to spread from Yale University to elsewhere in the United States and around the globe. This renaissance set in motion two important changes in the discipline. These changes have occurred gradually, but a time traveler would now find them striking. One change had to do with the priority given to the rigorous estimation of causal effects. Prior to 1998, political scientists valued the enterprise of estimating cause-and-effect relationships, but they placed little emphasis on the role of research design, Field Experiments in Comparative Politics and Policy


BEZDÍČEK, J.: Allele and genotype frequencies of milkprotein kappa-casein (CSN3) in artifi cal insemination bulls of Czech Fleckvieh and Holstein breed. Acta univ. agric. et silvic. Mendel. Brun., 2007, LV, No. 5, pp. 17–22 This thesis was meant to evaluate allele and genotype frequencies of kappa-casein (CSN3) in artifi cial insemination bulls in the Czech Republic of Czech Fleckvieh breed (n = 133) and Holstein breed (n = 58). Studied bulls were born between 1990 and 2005. Calculation was made by PowerMarker (Liu K., Muse S.V. 2005). Genotype frequencies established in Czech Fleckvieh bulls were AA = 0.391 AB = 0.4887 AE = 0.0075 BB = 0.0902 BE = 0.0226 and EE = 0 and allele frequencies were A = 0.6391 B = 0.3459 E = 0.015. Genotype frequencies established in Holstein bulls were AA = 0.5517 AB = 0.2759 AE = 0.1207 BB = 0 BE = 0.0345 and EE = 0.0172 and allele frequencies A = 0.75 B = 0.1552 and E = 0.0948. In Holstein breed we found higher frequency of E allele and higher frequency of genotypes with this allele. Genetic diversity, heterozygosis and PIC values in Czech Fleckvieh Bulls were following 0.4717; 0.5188 and 0.3737 and 0.4044; 0.4310 and 0.3668 in Holstein Bulls. These results show the higher genetic variability in bulls of Czech Fleckvieh breed. Results of χ2 test (Czech Fleckvieh 4.58; Holstein 2.55) show genetical disequilibrium in the Bulls both examined breeds used in artifi cial insemination in the Czech Republic. kappa-casein, allele frequencies, genotype frequencies, Czech Fleckvieh bulls, Holstein bulls Concerning bulls of Czech Fleckvieh and Holstein breed, which are active in an artifi cial insemination, determination of milkprotein kappa-casein (CSN3) is very important information. And it is not only for cow-breeders but also for farmers. The determination of the genotype is relevant in relation to milk, protein and fat yield and also for milk quality. Kučerová et al. (2006) detected increased protein and fat content in milk in population of Czech Fleckvieh breed of BB genotype. In the observed population frequencies of CSN3 allele B (0.38) and BB genotype (13%) were detected. The effect of AA CSN3 genotype on milk, protein and fat yield and effect of AA genotype on protein and fat percentage was found by the author also in her former study (Kučerová et al., 2004). A signifi cantly higher difference in protein production (p < 0.05) was determined between AB and BB CSN3 genotypes in the fi rst lactation of dairy cows of the Slovak Fleckvieh breed (Žitný et al., 1996). Dairy cows with AB genotype produced on average by 17 kg of proteins more than the group of cows with BB CSN3 genotype. Eenennaam et al. (1991) obtained the highest milk yields for the BB genotype from 1454 fi rst lactation heifers of California dairy cattle population. Negative effects of E allele on milk production parameters and pro-


Soybean growers this fall may have problems with green stem and mottled seed. Many of the problems may be caused by bean pod mottle virus (BPMV) or soybean mosaic virus (SMV). Both viruses cause the same leaf symptoms, green stem in the fall, and mottled seed coats. BPMV is transmitted primarily by bean leaf beetle; SMV is transmitted by at least 30 aphid species, including the newly introduced soybean aphid. Many soybean cultivars do not display obvious symptoms, and there is no positive correlation between severity of leaf symptoms and amount of seed coat mottling on fall-harvested seed.


Remembrance is a way of loving, that gloved hand you lay upon cold stone, emerald fields. Judy, my sister, you and I both know it's loneliness hid behind that curtain, the twister in the gut that picks us up, hurls us to heaven, the last things we own rags upon our backs. So sing, baby. Sing until that rainbow posits us somewhere over the rain clouds, over the starlight, over— the tangle and tatter of America— and done with. When you left the club that night, your last number still trembling the flames in their colored globes, I touched your dress—the even crossings of the threads a second skin against your hip, and I wondered what fresh hells the gods could demand of us.


Over the past decade Surface Plasmon Resonance (SPR) techniques have been applied to the measurement of numerous analytes. In this article, an SPR biosensor system deployed from an oceanographic vessel was used to measure dissolved domoic acid (DA), a common and harmful phycotoxin produced by certain microalgae species belonging to the genus Pseudo‐nitzschia. During the biosensor deployment, concentrations of Pseudo‐nitzschia cells were very low over the study area and measured DA concentrations were below detection. However, the in situ operational detection limit of the system was established using calibrated seawater solutions spiked with DA. The system could detect the toxin at concentrations as low as 0.1 ng mL−1 and presented a linear dynamic range from 0.1 ng mL−1 to 2.0 ng mL−1. This sensor showed promise for in situ detection of DA.


Health care utilization by children and adults with severe neurological impairment (SNI) has been increasing and is likely to continue to do so. SNI is often complicated by complex comorbidities such as malnutrition, bone disease, epilepsy, gastro-oesophageal reflux disease, and chronic suppurative lung disease. Enteral feeding is increasingly becoming the norm. Gastrostomy feeding has been shown to improve nutritional status including increasing total body protein, though concerns remain that it primarily increases body weight and fat. Indeed, Vernon-Roberts et al. suggest that children with neurological impairment are at risk of overfeeding, leading to excessive gain of body fat. They report that the use of a low energy, micronutrient complete, high-fibre diet allows children to continue to grow, but not accumulate excess body fat with energy intakes less than 75% of estimated average requirement. The authors should be commended for this study, which utilizes sophisticated body composition measures to assess body fat. They did so in a notoriously difficult group to recruit and study. Their aims were to attempt to answer an important question about how children with SNI should be nourished enterally. However, the findings of this study need to be interpreted with great care before clinicians alter their practice. Recruitment difficulties left the investigators with a small number of patients and these may not be typical of patients with SNI undergoing enteral feeding. Gastrostomy feeding is often recommended for undernutrition. However, the patients described in this study had median body fat measures at baseline of 28%. This is well within the normal range for children. In this setting it was appropriate that the clinicians adjusted energy intake to ensure growth without excessive weight gain. The patients at baseline were also young (median 2y) and follow-up was only 6 months. In our experience, overfeeding is unusual in the older patient with SNI because of the burden of care for caregivers of the larger immobile child. These patients are more likely to be undernourished. It is important to recognize that many patients with SNI in whom enteral feeds are instituted are malnourished. Thus, recommended intakes need to make provision for nutritional rehabilitation or catch-up growth. Some have chronically adapted to reduced intake and have abnormally low energy expenditure, which increases after the institution of enteral feeds (unpublished data; Arrowsmith F, Somerville H, Gaskin K, O'Loughlin E). Moreover, we have recently demonstrated that, even with aggressive nutritional rehabilitation in older children with cerebral palsy, their growth parameters, including body fat are, in general, still well below the normal range. This study also raises interesting questions of how to assess nutritional status in patients with SNI, given the difficulties of using standard anthropometry. The authors rightly focussed on body weight and fat, as previously suggested by Stallings et al. but the techniques used are not generally available. Even assessing body fat with skinfold callipers requires expertise but could be utilized in a specialist multidisciplinary setting. Another important question is 'What do clinicians aim for in terms of nutritional status when instituting enteral feeding?' Given the serious comorbidities and difficulties associated with gastrostomy feeding (e.g. reflux and aspiration) clinicians probably should be aiming for adequate rather than normal nutritional status. What constitutes normal nutritional status in children with SNI? The answer is not clear and will require long-term nutritional studies in the future. We are concerned with the authors' contention that children with severe CP 'will grow ... even on energy intakes which are 50% of estimated average requirement for normal children'. Children with cerebral palsy and other forms of SNI are heterogeneous and have serious comorbidities that complicate feeding, so that a 'one size fits all' approach is inappropriate. Rather, children should be regularly monitored in a multidisciplinary setting where appropriate adjustments, not only of nutritional parameters, but also of other clinical indices such as general health (respiratory and epilepsy management, treatment of gastro-oesophageal reflux disease, bone health) and quality of life for both child and caregiver can be made.


The aims of this study were to investigate the fouling mechanisms of model organic compounds (MOCs) on two ultrafiltration membranes [composite regenerated cellulose (YM100) and polyethersulfone (PES)] and the relationship between fouling and membrane characteristics, flux decline, and the streaming potential (SP). Two alginic acids (polymer and dimmer, AA), abietic acid (AbA), colominic acid (CA), and N-acetylneuraminic acid (NA) were selected as MOCs to test their membrane fouling potential through flux decline and SP. The fouling caused by the two AAs, which contained many polysaccharides, was the highest among MOCs, but this fouling was external (solute deposition on the membrane surface) and reversible as polysaccharides did not strongly adsorb onto the YM100 and PES membranes. CA also caused external fouling of the two membranes; however, AbA caused internal (solute adsorption on the pores wall of membrane) and irreversible fouling of the PES membrane. NA, which contained amino sugars, exhibited very low fouling of both membranes. The hydrophilic YM100 membrane experienced less fouling than the hydrophobic PES membrane with all MOCs. The measurement of the SP using a modified dead-end filtration cell was employed to evaluate the flux decline due to MOCs.


We describe a modified maximum likelihood method that overcomes the problem of complete or quasicomplete separation in multinomial logistic regression for discrete choice models with finite samples. The modification consists of augmenting the observed data set with artificial observations that reflect a prior distribution centered on equal choice probabilities. We demonstrate through Monte Carlo simulations of data sets as small the minimum degrees of freedom case that the modified maximum likelihood approach leads to superior parameter recovery and out of sample prediction compared to conventional maximum likelihood. We explore the role the prior weight plays on parameter recovery and out of sample prediction by varying the weight given to the prior versus the weight given to the data in the likelihood function. We demonstrate a numerical procedure to search for an appropriate weight for the prior. One application for the proposed approach is to estimate discrete choice models for single individuals using data from discrete choice experiments. We illustrate this approach with Monte Carlo simulations as well as four data sets collected using online discrete choice experiments.


Purpose: The purpose of this study was to evaluate the great saphenous vein (GSV) as a conduit for crossover femoro-femoral bypass. Generally the conduit for crossover femoro-femoral bypass is a synthetic material because of the acceptable long-term patency and low complication rates. But, as the average life expectancy becomes extended, a better patency rate becomes more important. In this study, we compared the patency rates and hemodynamic results between crossover femoro-femoral bypass operations with GSVs and those with synthetic grafts. Methods: From 1998 to 2008, 119 femoro-femoral bypass operations were done. Among them, 38 femoro-femoral bypass used GSV as a conduit (group I) and 79 operations used expanded polytetrafluoroethylene (group II). Two cases used arm veins and we excluded those cases. Results: The 3 year primary patency rate of total cases was 75.1%, 93.7% in group I and 66.1% in group II. There were no statistical differences in hemodynamic results such as peak systolic velocity, volume flow and ankle/brachial systolic pressure index between the two groups. Conclusion: The 3 year primary patency rate of group I was better than that of group II. However there were no differences in hemodynamic changes. So GSV is recommended as a conduit for crossover femoro-femoral bypass especially in young patients who are eager to have longer patency rates after surgery instead of less invasive endovascular therapy.


This chapter covers poisoning by members of the fungal subkingdom Dikarya that includes most of the 'higher fungi'. The phylum Ascomycota contains the medically important toxic fungi Claviceps purpurea, the cause of ergotism, Aspergillus flavus, a source of hepatotoxic and carcinogenic aflatoxins, the edible but potentially toxic morel mushrooms (Morchella species), Gyromitra species, and Podostroma cornudamae that has caused multisystem symptoms and signs. The phylum Basidiomycota includes the order Agaricales (gilled mushrooms/toadstools or agarics) to which most of the medically important larger fungi belong. 'Mushroom' and 'toadstool' may suggest 'edible' and 'poisonous' respectively, but these terms are not strictly applied. Poisonous species must be distinguished from field (Agaricus campestris) and cultivated (A. bisporus) mushrooms and from the many other mushrooms that are considered to be delicious and are passionately sought after by mycophiles worldwide.


NiCO3 and CoCO3 react with hydrogen to produce methane at 200–250 °C without any additional catalysts, and some alkali or alkaline-earth metal carbonates are also hydrogenated at 300–400 °C to form methane using transition metal powders as a catalyst.


AbstractWe observe a stable intermediate resistance switching state in the currentperpendicular to plane geometry for all Co/Cu/Co double layer nanopillarjunctions grown by molecular beam epitaxy. This novel state has a resistancebetween the resistances of the parallel and antiparallel alignment of both Co-layer magnetizations. The state, which originates from an additional in-planemagnetic easy axis, can be reached by spin transfer torque switching or by anexternal magnetic field. In addition to spin torque-induced coherent small-anglespin wave modeswe observe abroadmicrowave emission spectrum. Thelatteris attributed to incoherent magnetic excitations thatlead to aswitchingbetween the intermediate state and the parallel or antiparallel alignment ofboth ferromagnetic layers. We conclude that the additional magnetic easyaxis suppresses a stable trajectory of coherent large-angle precession, whichis not observed in our samples. Keywords: ∗ Corresponding author Emailaddress: firstname.lastname@example.com(B. Beschoten)


The EMW at the BESSRC beam lines at the APS provides high photon flux at high energies with the capability of producing circular polarization on axis. We observe a high degree of circularly polarized x-rays at such energies. The polarization and frequency tunability of the elliptical multipole wiggler (EMW) is an ideal source for many magnetic measurements from X-ray Magnetic Circular Dichroism (XMCD) to Compton scattering experiments. We performed Compton scattering measurements to determine the polarization and photon flux at the sample as a function of the deflection parameters Ky and Kx. We used for our measurements a Si (220) Laue monochromator providing simultaneous photon energies at 50 keV, 100 keV and 150 keV. Magnetic Compton Profiles were determined by either switching the magnet polarity or the photon helicity. The results obtained using Fe(110) single crystals were very similar.


SUMMARY

The mathematical description of the normal modes of the rotating self-gravitating stratified compressible liquid core is shown (in the absence of dissipation) to rest exactly on only two scalar fields. These two potentials are governed by a coupled pair of second-order linear partial differential equations which follow from a new variational principle (VP). The latter is simpler for computational purposes than the conventional VP involving four field variables. One of the two new equations reduces to the subseismic wave equation (SSWE) when the effect of flow pressure on compression is neglected. A VP for the SSWE exists only when the Earth model is further constrained, but the VP for the two-potential formulation of core dynamics is valid, without approximation, for any core stratified in accord with hydrostatic equilibrium, with elastically deformable oblate boundaries.


The TiC coating was prepared on TC4 alloy using argon arc cladding method of graphene and titanium powder to improve wear resistance. The microstructure and phase of coating was observed by XRD, OM and SEM. The properties of coating were tested by microhardness-tester and dry slipping friction tester. The results show that the coating consists of TiC and Ti, and the composite coatings have good bonding with substrate. The in-situ synthesis of TiC particles are uniformly distributed in the composite coatings, and the morphology of TiC particles are composed of particle-shaped, rod-like and flower-like morphologies. The average microhardness of composite coating can reach 835 HV, about 2.8 times of the substrate. The composite coating has excellent tribological properties.


List of illustrations Preface Abbreviations and conventions Introduction 1. The significance of the quarto text 2. The nature of playhouse manuscripts 3. The history of Henry V's quarto text 4. The quarto printings 5. The copy for and printing of Q1 6. The so-called 'reporters' of Q1 7. Compositor errors in Q1 8. Mishearings from dictation 9. Re-lineation 10. Premeditated revisions 11. Reassignments of parts 12. Q's use of the cuts from F 13. Verbal alterations for consistency 14. Shakespeare's changes or the players'? 15. Stage history Note on the text List of characters The Play Textual notes Appendix 1: some of Q's re-lining of verse Appendix 2: Q's rendering of Pistol's lines as verse Bibliography.


Objective: The main objective of this study was to describe the use and limitations of tonsil scrapings (TS), oral fluids (OF), nasal swabs (NS), and environmental swabs (ES) to detect porcine reproductive and respiratory syndrome virus (PRRSV). Materials and methods: Two PRRSV-positive growing pig farms using different PRRSV control strategies were enrolled in this study. Sampling began approximately 52- and 21-days post PRRSV exposure for farms 1 and 2, respectively, and occurred once a month for four months using fixed spatial sampling. Samples for OF and ES were collected at the pen level and TS and NS samples were collected at the individual level. All samples were tested using reverse transcriptase-polymerase chain reaction (RT-PCR). Results: A total of 192 samples were collected over the study period: 48 TS, 48 OF, 48 NS, and 48 ES. Overall, 20 TS (41.6%), 0 OF (0.0%), 6 NS (12.5%), and 1 ES (2.1%) tested RT-PCR positive for PRRSV throughout this study. Implications: Tonsil scraping samples yielded more positive PRRSV RT-PCR results for longer time periods when compared to OF, NS, and ES for PRRSV detection in growing pigs. Tonsil scraping samples tested RT-PCR positive for PRRSV up to 168 days post exposure. Oral fluids, NS, and ES sampling methods for PRRSV detection in growing pig populations, particularly months after the initial infection or vaccination, should be used with caution given low RT-PCR positive samples found in this study.


What is Lifelong Leaming? ............................................................... .i The Public Health Workforce in the United States Who they are and what they do ..... ................................................... 1 The Eleventh Essential Service in Public Health Prepare for and respond to disasters ................................................ 8 Training, Educating, and Preparing the Public Health Workforce: Competencies as a Benchmark Who gets what and why ................................................................ 11 An Academic Health Department Model Building a learning organization: Workforce development in the context of practice ............................... 16 Lifelong Learning in Public Health Where do we go from here? Combining the system. the workforce. and the issues ........................ 22 References ............................................................................... 28


Given that the transhumanist vision of the world is frequently painted as desirable for people and optimistically utopian, the article's aim is to investigate one of such visions, imagined by Scott Westerfeld in The Succession duology to see if such a utopian model accounts for the necessity of the survival of humanity. While avoiding the usual strictly dystopian and alarmist scenarios, Westerfeld's postmortal and extropian world is rife with challenges to the transhumanist ideas, asking about the actual grounds on which future communication and cooperation would be based, and the limits of enhancement that need to be drawn not to lead to dehumanization.


The politics of education came from its parent discipline of political science. In the course of its development, an integrative-aggregative tension appeared. The macro-micro divide in the politics of education is a controversial topic. Although the scholars in the politics of education have made great contributions to the field, disagreement still exist in the basic conceptions, theoretical frames and foundations.


Tetrabasic lead sulfate(4BS) is one of the precursors of the electrode active material in lead acid batteries.An excellent active material structure can be obtained after formation when the cured plates contain a high amount 4BS.The cycling life of the batteries is longer and the premature capacity loss(PCL) can be avoided effectively.The primary production methods of 4BS pastes during recent years were presented mainly from the paste mixing process and curing process,the structure of 4BS obtained by different production methods and its impact on battery's performance were discussed.The application of 4BS for high-performance lead acid batteries was also prospected.


Bauer and Swanson ' s paper is an important contribution to the litera-ture measuring the dynamic effects of monetary policy shocks on the macroeconomy. It shows what can go wrong using apparently exoge-nous high-frequency monetary policy surprises as instruments for monetary policy shocks, and it shows how to correct the faulty estimates and inference by incorporating appropriate control variables. It is also the fi rst paper to use the expanded set of monetary policy surprises com-piled by Swanson and Jayawickrema (2022), another important contribution. The culmination of the authors ' work is the monthly impulse responses shown in fi gure 8 of the paper. These are the new benchmark impulse response functions for the effect of Federal Reserve monetary policy shocks on the US macroeconomy.


Four materials of Elymus were compared in growth period,grass yield,seed yield and stem/leaf ratio in dry farming to provide theory base for construction of ecological environment and seed production in arctic-alpine region of Qinghai-Tibet Plateau.They could winter safely in Tongde region,which showed strong capacity of drought,cold-resistance.The yield of the tested materials was the highest in second year.The yield of Elymus sibiricus L.cv.Qingmu No.1 and Elymus sibiricus L.cv.Tongde was higher,their fresh grass yield,dry grass yield and seed yield in second yield were 36500.2 kg/hm2,44894.6 kg/hm2,908.7 kg/hm2 and 35500.2 kg/hm2,10924.0 kg/hm2,902.4 kg/hm2 respectively,they were good herbage for livestock with richer leaves.Four materials can be cultivated in arctic-alpine region of 3200 m in altitude in Qinghai-Tibet Plateau.


In this paper a comparison is made between OpenModelica and Dymola for a simulation model of a power boiler. The similarities and differences are presented. Dymola has the advantage of having a more elaborate user interface and solver, but the OpenModelica user interface and solver has improved very much during last few years. The advantage of OpenModelica is that anyone can use the models without having to pay high license fees, something that is of significant interest when installations are made in industries. In many ways a combination of the two is advisable, where Dymola can be used for application developments and later OpenModelica can be used in the actual installations. It has been seen in this application for a CFB boiler that it is easy to use the same model in both environments without any modifications. Still, the solver for OpenModelica is not as powerful as for Dymola, which may be a problem for on-line applications for larger models, while no problem for small models. Introduction and Literature Review 1 Methodology E Dahlquist et al. Comparison Open Modelica – Dymola for Power Plant Simulation 140 SNE 23(3-4) – 12/2013 TN Air flow to boiler Figure 1: View of the CFB boiler in Dymola interface. Showing boiler 5 at Mälarenergi CHP plant. E Dahlquist et al. Comparison Open Modelica – Dymola for Power Plant Simulation SNE 23(3-4) – 12/2013 141 T N 2 Model Validation and Results E Dahlquist et al. Comparison Open Modelica – Dymola for Power Plant Simulation 142 SNE 23(3-4) – 12/2013 TN Figure 2: Bed temperature at the same elevation for eight meters. Part load (July 5, 2011) at 6.2 kg/s fuel, 30.1 kg/s Variables DCS RH Errror% Steam temperature after HPSH2 (°C) 434 439 1.0 Fluegas temperature after cyclone (°C) 550 566 2.9 Fluegas temperature before cyclone (°C) 551 576 4.6 Steam temperature after cyclone (°C) 366 353 -3.6 Full load (September 2011) 16.5 kg/s fuel, 79.8 kg/s air, 48.8 kg/s feed water Steam temperature after High Pressure Super Heater 2 (°C) 494 488 -1.2 Bed temperature (°C) 833 879 5.2 Fluegas temperature before cyclone (°C) 758 757 0 Steam temperature after cyclone (°C) 385 379 -1.5 Table 1: Measured process data (DCS) compared to predictions made with the simulation data. 3 Comparison of Dymola and OpenModelica from a User Perspective E Dahlquist et al. Comparison Open Modelica – Dymola for Power Plant Simulation SNE 23(3-4) – 12/2013 143 T N Figure 3: Difference between simulated and measured data for five variables in boiler 5 July 4-7 2011. E Dahlquist et al. Comparison Open Modelica – Dymola for Power Plant Simulation 144 SNE 23(3-4) – 12/2013 TN Figure 4: Bayesian Net of differences between simulated and measured data from Boiler 5 during the period September 10 to September 18, 2011. E Dahlquist et al. Comparison Open Modelica – Dymola for Power Plant Simulation SNE 23(3-4) – 12/2013 145 T N 4 Discussion and Conclusions Acknowledgments. References Proceedings of the 8th International Modelica Conference (Modelica'2011) Mathematical and Computer Modeling of Dynamical Systems: Methods, Tools and Applications in Engineering and Related Sciences Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference Applied Thermal Engineering ipw Two dimensional web property variation modeling and control Journal of Loss Prevention in the Process Industries Demandbased maintenance and operators support based on process models E Dahlquist et al. Comparison Open Modelica – Dymola for Power Plant Simulation 146 SNE 23(3-4) – 12/2013 TN Water research Principles of Object Oriented Modeling and simulation with Modelica 2.1 . Journal of Process Control TAPPSA Journal 15th IEEE International Conference on Engineering of Complex Computer Systems (ICECCS) Control Engineering Practice Chemical Product and Process Modeling Water Research Control Engineering Practice Proceedings Control Systems Proceedings of the 8th International Modelica Conference (Modelica'2012) Applied Energy Applied Thermal Engineering


The Internet has introduced a variety of online buying services that expand the reach of sellers and reduce search costs for buyers. In markets in which traditional outlets tend to establish prices through bargaining, these online intermediaries have also altered the price setting process. Perhaps the most well known example is Autobytel.com which provides referral services in the automobile market. By using Autobytel, a buyer can obtain a posted price as an alternative to bargaining with a car dealer ship. To understand the effect of online referral systems on the price setting process, we construct a theoretical model of oligopolistic price competition in which one dealership has an exclusive contract with a referral intermediary. We show that posted prices offered through the referral system are not necessarily lower than offline prices (bargained prices). Our model provides theoretical insights relevant to results in the empirical literature addressing the role that Autobytel and other infomediaries play in online markets.


The aim of the study was detection and identification of root knot nematodes infecting the flower crops cultivated in open air and indoor. Studied biological material consist of nematodes was obtained from soil and infested plants using two methods, namely enzymatic digestion for plants samples and Baerman funnel for soil samples.The identification of nematodes has been based on morphobiometrical and molecular characters. It has been identified Meloidogyne incognita (Kofold & White, 1919) Chitwood ,1949 in two samples.


The elementary birch synusia of autotroph determined consortium separated in constellation on singular taxation indication (forest stand origin) in aspect of Betula pendula Roth impaction by the Inonotus obliquus (Pers.) Pil. is positioned.


Deep Sea Drilling Project/Ocean Drilling Program Holes 504B and 896A were drilled into the upper oceanic crust of the Costa Rica Rift, only 1 km apart. Thus they provide an excellent opportunity to study lateral variation in the volcanic-rock section of the oceanic crust. Recovery of cores from these holes was poor. Therefore, comparison of one hole with the other is based on continuous information from geophysical well-logging data. Continuous lithologic profiles were created by calibration of logging data to cores, followed by statistical analysis.


Important information can be obtained from smartphone users data such as profile modeling, behavior recognition, geolocalization, etc. Human activity recognition (HAR) from sensor smartphone data is a field which has garnered a lot of attention due to its high application in various domains such as the user health. In this paper, we will consider data from accelerometer to recognize the kind of user movements that we will classify to six kinds using machine and deep learning algorithms. Then, based on these results, we will make a recommendation system to inform the users of smartphone about their healthy behavior related to their physical activities.


To the Editor: The systematic review of the effects of omega-3 fatty acids on cancer risk by Dr MacLean and colleagues concluded that dietary supplementation with omega-3 fatty acids is unlikely to prevent cancer. We would like to raise some of our concerns about this review. Thirty-eightprospectivestudieswereselectedforreviewbased on prespecified criteria. However, none of these studies measured fatty acid composition in patients. The food frequency questionnaire and dietary records correlate poorly with direct measurements of fatty acids in patient samples and are prone to measurement error. Ultimately, the effect of omega-3 fatty acids depends on levels achieved in individuals. Fish cannot synthesizeomega-3fattyacidsdenovobutrather ingesteicosapentaenoic and docosahexaenoic acid present in phytoplanktonandzooplankton. Thus, some fish(especially farm-raised fish)arepoorsourcesofomega-3fattyacids.Wethereforethink that a more accurate conclusion of this study is that a preventive effect of omega-3 fatty acids on cancers is still uncertain. We also disagree with the authors on their assessment that animal studies "do not come close to replicating human exposures." Animal models, especially those developed recently, can closely mimic the clinical course of cancer progression, and are invaluable tools for mechanistic studies that cannot be performed in humans. Animal diets are designed with varying ratios of omega-3 to omega-6 fatty acids, both of which are essential fatty acids required for mammals to survive. It is the ratio of omega-3 to omega-6 that is important for deducing their mechanistic functions, and animal diets have been formulated to reflect human consumption.


The work described in this thesis presents part of a
 framework that can be used to extract
 detailed disease biological information from peripheral tissue. This
 framework is based
 on the central dogma of biology "DNA to RNA to protein" and on a systems
 biology
 approach that aims to produce synergetic data whose disease pathological,
 prognostic
 and predictive value is greater than the sum of the individual experiment
 results. HD
 patients are often characterized by a multifaceted clinical profile,
 consisting of several
 symptoms and variable disease progression rates. Therefore, a systems
 approach such as
 the one described above is expected to be the most effective in identifying
 potential treatments
 and predictive biomarkers that will be most informative for the different
 patient
 subpopulations.


FIELD: transport. SUBSTANCE: invention relates to protection of nonterrestrial objects against space refuse, meteorites and other dangerous objects and to cleaning of near-Earth space environment of dead artificial satellites, their fragments etc. proposed method consists in making obstacle to affect refuse by kinetic shock effects. Note here that said obstacle is composed of several compact obstacles, each being made up of regularly distributed pelletised explosive. Conical strikers (vertex angle of 45° to 90°) are arranged at obstacle vertices. Said strikers may be composed of containers for explosive. Quantity of sprayed obstacles and distance between them is defined proceeding from expected sizes of refuse and relative speed on approach. Note here that energy of oncoming refuse flow should be lower that that brought about by obstacles and strikers. EFFECT: higher efficiency. 2 dwg


Rational taxation system has the effect of equalizing income.Because of the different expenditure structure,there are differences between the urban and rural residents' tax burden.Based on the statistical data of China Urban Life and Price Yearbook and China Yearbook of Household Survey,we calculate separately the income redistribution effect of main taxes on urban and rural residents in China.The result shows that China's taxation has the negative effect on residents but the degree of the negative effect is fading,especially in rural areas.By comparing the redistribution effect of urban and rural residents,we suggest adjusting the structure of the current tax system,perfecting the mechanism to monitor the income and optimizing the adjustment direction and strength of tax incentives.


Background: Thymoma size, stage, and postoperative therapies affect patient survival. First, the current study attempted to reveal the relationship between mediastinal lymph node involvement (LNI) and thymoma patient survival. Second, this study aimed to evaluate the efficacy of lymph node dissection (LND) during surgery. Methods: Thymoma patients with LND during surgery were enrolled in the Surveillance, Epidemiology, and End Results program database (SEER). Survival, based on age, tumor size, Masaoka stage, and LNI status, was analyzed via univariate and multivariate analysis. The efficacy of adjuvant therapies and LND was analyzed by stratification analysis in each WHO pathologic grade. Results: In all 399 patients, old age, advanced clinical stage, and positive LNI predicted significantly worse overall survival (OS) (P = 0.044, 0.012, 0.032). Postoperative radiotherapy and chemotherapy showed significant benefits for positive LNI patients (P = 0.003, 0.020), but adjuvant treatments did not affect the OS of negative LNI patients. Moreover, Masaoka Stage I patients receiving less than 2 lymph nodes removed with LND had significantly better OS than those with more than 3 (P = 0.038). However, in advanced stage, different numbers of LND did not affect patient OS. Conclusion: Diagnostic age, clinical stage, and LNI status were shown to be independent risk factors for OS. Compared with old age, advanced stage, and positive LNI patients, younger, local stage and negative LNI patients showed significantly better prognoses. Radiotherapy or chemotherapy significantly improved positive LNI patient OS. Stage I patients dissecting 1 or 2 lymph nodes manifested significantly better OS than those dissecting lymph nodes more than 3.


The demand for rare earths in aluminum alloy industry has experienced substantial growth in recent years. The erbium and scandium are two effective rare earth additives, mainly due to its remarkable improvement to aluminum alloy performance. However, the production process of rare earth has caused significant environmental problems. Hence, the analysis of environmental impacts associated with erbium and scandium processing is gaining importance. In this study, a life cycle analysis on the environment impacts of erbium oxide (Er2O3) and scandium oxide (Sc2O3) was carried out based on life cycle assessment (LCA) method. The life cycle assessment results showed that the production of 1 kg of Er2O3 and Sc2O3 generated 21.7 kg CO2 eq. and 743 kg CO2 eq., respectively. The leaching and purification process accounting for 95% of the overall water usage of Er2O3 production. For Sc2O3, energy and chemical consumption played a key role in reducing environmental impacts. Furthermore, Er2O3 appeared to have less environmental impact than Sc2O3 on most environmental issues. A detailed review of contribution was conducted and recommendations for further research were given.


: This paper reviews the development of the passivated emitter, rear locally diffused (PERL) silicon solar cell. The main focus of this text is on the fabrication technologies available to process such cell structure. When PERL solar cell was first introduced, it achieved an efficiency record of 24% in a laboratory setting. However, it had very limited commercial usage due to its complex fabrication process. Nowadays, companies such as Suntech Power has commercialised products based on PERL cells. Thus, reviewing all the fabrication technics that can be implemented to manufacture PERL solar cells might enable us to transform certain advanced laboratory fabrication technics to be suitable for commercial usage.


ust before Christmas 1997, the casual reader of the Economist-if that isn't oxymoronicmight have skimmed an article about subsidies in the United States and their impacts on land use, especially in the American West. The figures cited in the article were indeed impressive. Take mining, for example: between May 1994 and September 1996, the United States sold land containing some $16 billion worth of minerals for J


We present the results of a first campaign of radio continuum observations toward supergiants with spectral types in the range O8 - B3. Three targets out of twelve were detected with the ATCA and the VLA. The measured fluxes and the upper limits yielded values of the stellar mass-loss rates dM/dt and the wind efficiencies. The comparison of predicted and derived values of dM/dt shows a good agreement.


Zein E. Obagi. The Art of Skin Health: Restoration and Rejuvenation , 2nd edition. Boca Raton, FL: CRC Press, 2014. ISBN-10: 1842145967, ISBN-13: 978-1842145968. $199.95.

![Graphic][1]

This book was presented for review to me as a cosmetic dermatologic surgeon with authorship of textbooks on chemical peeling and as a teacher of many of the procedures shared by plastic surgery.

This new textbook is a consolidation of Dr. Obagi's opinions and a compilation of the basic existing knowledge, reviewing practically everything one might need to reverse photo damage and aging skin.

Chapter 1 is a basic science skin presentation for the nonphysician or the relatively inexperienced physician, complete with references.

Chapter 2 expands principles on the reversal of cosmetic benign skin changes, which the author claims is not performed well by the specialty of dermatology. In my opinion, that may have been the case 20 years ago. His principles of skin restoration are excessively discursive and are extensively presented.

Chapter 3, written by the author's associate, is an encyclopedic consolidation of every topical agent, including growth factors and barely-effective cosmeceuticals, available to treat the most common skin diseases. This is geared towards the physician rather than the nonphysician.

Chapter 4 on the author's skin classification system incorporates botulinum toxin, lasers, fillers, and his peels, and it may be inferred that the author believes that his system is superior to the existing system of judging whether these procedures are indicated.

Chapter 5 on rejuvenating the skin presents accurate points but nothing new to a physician familiar with existing principles of cosmetic dermatologic and plastic surgery. However, the author's interpretation of peel depth and his non-peer-reviewed claims that his …

Corresponding Author: Dr Harold J. Brody, 1218 West Paces Ferry Road, Suite 200, Atlanta, GA 30327, USA. E-mail: drb{at}atlantadermatology.com

 [1]: /embed/inline-graphic-1.gif


The purpose of this study was to analyze the factors of accounting expertise, new literacy, and motivation on the job readiness of prospective accountants in the Covid-19 pandemic era. This research was conducted at Universities spread across Bali which have A & B accredited Accounting Study Programs in 2021. The number of samples used was 93. Data was collected by distributing questionnaires. The data analysis technique in this study used multiple linear regression analysis with the Smart-PLS tool. The results of the study prove that Accounting Skills have a positive and significant effect on job readiness. New Literacy has a positive and significant effect on job readiness. Motivation has a positive and significant effect on accounting expertise on job readiness. Motivation has a negative and insignificant effect with new literacy on work readiness.
Keywords: Accounting Skills; New Literacy; Motivation; Working Readiness.


In February 2012, several plants of physic nut (Jatropha curcas) growing in Assiut Governorate (Egypt) showed shedding of the leaves, blackening and decaying of the collar region of the stem and necrotic lesions on branches. A fungus was consistently isolated on potato dextrose agar (PDA) from symptomatic branches. Single-spore fungal cultures produced white, aerial mycelium that became dull gray after a week in culture. The mycelium was fast spreading, branched and septate. Pycnidia from 30-day-old pure cultures produced dark brown, oval conidia that were two celled, thin walled, and oval with longitudinal striations. The average size of the conidia was 23.64×12.73 μm with a length/width ratio of 1.86. Conidia were initially unicellular, hyaline, thick-walled with granular content. Based on conidial morphology, the fungus was identified as Lasiodiplodia theobromae. To confirm the identity of the mycete the internal transcribed spacer (ITS) region was amplified with ITS1/ITS4 primers and sequenced. Sequences of the isolates were 99% identical to two L. theobromae accession from GenBank (HM008598 and HM999905). Five 1-year-old healthy plants of J. curcas were inoculated inserting a 10-mm PDA plug of mycelium into the wound and wrapping the inoculation site with wetted cotton wool and Parafilm. Ten non-inoculated plants served as control. After 6 days, all inoculated plants produced the same symptoms. while controls remained symptomless. The pathogen was reisolated from inoculated branches, fulfilling Koch's postulates. L. theobromae has been reported to cause cankers and dieback in Malaysia (Sulaiman and Thanarajoo, 2012) and India (Latha et al., 2009). To our knowledge, this is the first report of stem canker associated with L. theobromae of physic nut in Egypt.


This thesis explores the encounter between the Afghan-American community and the U.S. military-industrial complex in the production of cultural knowledge for counterinsurgency (COIN) operations in Afghanistan. It focuses on the narratives mobilized as 'expertise' by Afghan-American contractors from the major diaspora hubs in California and Virginia, who were employed as role-players, translators, and cultural advisors by the U.S. military and defense contractors. I discuss how such narratives gained currency and shaped the perceptions of Afghanistan in the U.S. foreign and security policy communities. The goal of the thesis is to demonstrate the extent to which COIN-centered cultural knowledge production both defined political strategies toward Afghanistan and also reconstituted the Afghan diaspora in America. The thesis contributes to emergent ethnographic studies on militarism by looking at its effect on American society in general and the Afghan diaspora in particular. The broader application of the thesis findings is to move beyond critiques of the troubled connection between anthropology and the military, and to analyze the relationship between citizens and the state in terms of national and biopolitical security.


Higher plants are prominent sources for several bioactive chemical constituents (secondary metabolites) who include photochemical, flavoring agents, fragrant molecules, and food additives. According to WHO estimates, it has been reported that more than 80% of population in developing countries prefer these natural bioactive active compounds for their primary health requirement. At present, conventional chemotherapy is constrained due to the nonselective toxicity to human organs and their usage is limited now a days. In a recent survey, more than 60% of cancer patients have been preferring adjuvant phototherapy along with chemotherapy. Thus, photochemical are being widely used as anticancer agents to target specific pathological pathways underlying cancer with low toxic profiles and side effects. These photochemical are cost-effective and easily accessible to the public to treat cancer diseases. These bioactive photochemical are meticulously belongs to secondary metabolites such as alkaloids, flavonoids, polyphenols.Among them, the flavonoids are polyphenolic substances, which are found in all parts of the plant such as flowers, fruits, leaves, roots, seeds, and bark. They possess high medicinal properties like being anti-cancer, anti-hypertensive, anti-inflammatory, anti-obesity, anti-malarial, antioxidant agents. Quercetin is major flavones associated with a profound antioxidant and medicinal property to prevent the oxidation of lipids in vitro and in vivo, and also exhibits direct proapoptotic effects on tumor cells. This compound has proven efficacy in targeting several cancer cells of breast, colon, prostate, ovarian, and lung tumor in vitro. The present review focuses on the effect of quercetin in cancer therapy.


This chapter reviews the recent research progress of graphene, with an emphasis on its thermal conductivity and its polymer nanocomposites. Thermal conductivity of nanocomposites can be measured by either the steady-state methods or the transient methods. As identified by the theoretical models, the effective thermal conductivity of composites can be affected by several key factors. In the case of graphene-polymer nanocomposites, most experimental reports have suggested that the key barrier in achieving superior thermal conductivity lies in the high interfacial thermal resistance between the graphene fillers and polymer matrices. To quantitatively understand the impact of interfacial thermal resistance on the effective thermal conductivity of graphene-polymer nanocomposites, Nan's theoretical model may be employed. The chapter discusses the definition of interfacial thermal resistance and the key factors affecting it. It reviews the approaches for reducing interfacial thermal resistance between graphene and polymer.


Approximately 9.2% of avian taxa are known to hybridize, a larger proportion than most vertebrate groups. However, rates of hybridization vary widely across avian orders: ducks and geese (Anseriformes) hybridize widely and frequently, while hybridization between swift species (Apodiformes) has never been recorded (Grant & Grant 1992). Seabirds, excluding the whiteheaded gull complex (Charadriiformes), are assumed to experience limited hybridization (Schreiber & Burger 2002). The potential for hybridization in seabirds may be lower than for other avian taxa because of the colonial nature of most species, elaborate courtship and thus stringent sexual selection, and/or the long-term pair bonds that many seabirds exhibit (Schreiber & Burger 2002).


The effects of phosphorus on atmospheric corrosion resistance of low carbon steels have been investigated by cyclic corrosion test、SEM and micro-Raman analysis.The results indicate that phosphorus can increase corrosion resistance of low carbon steels especially at the early stage of atmospheric corrosion.The phosphorus enriched on the face of steels was hydrolyzed,then phosphate was formed.This kind of phosphate cover on the cranny and holes in rust and resist water and oxygen's passing.Moreover,the H2PO-4 can accelerate the air oxidation of Fe2+ to Fe3+ and promote the formation of stable rust.As a result,the atmospheric corrosion resistance of high phosphorus bearing steels was improved.


Aluminum production process requires the formation of stamping the profile surface holes, slots and indentation.The indentation for stamping marks did not penetrate profile. Because of the indentation image with the surrounding untreated area having a high degree of similarity in appearance and the profile surface brightness varies, effective image segmentation and detection have difficult. In this paper, according to the characteristics of the surface morphology of indentation of aluminum profiles, the indentation image detection method is fast and effective.


A powerful data‐acquisition and processing system, which retains the low per‐station cost of a microcomputer‐based system while providing the resources for easy data reduction, is presented. The system uses microcomputer‐based real‐time data‐collection stations and a larger central computer for data‐reduction tasks. An application to the control of a continuous‐wave ultrasonic spectrometer is shown. In particular, the precision measurement of acoustic velocity as a function of temperature is presented for single‐crystal vanadium with a low concentration of interstitial hydrogen.


Atomicity is a fundamental correctness property in multithreaded programs. A method is atomic if, for every execution, there is an equivalent serial execution in which the actions of the method are not interleaved with actions of other threads. Atomic methods are amenable to sequential reasoning, which significantly facilitates subsequent analysis and verification.
 This article presents a type system for specifying and verifying the atomicity of methods in multithreaded Java programs using a synthesis of Lipton's theory of reduction and type systems for race detection. The type system supports guarded, write-guarded, and unguarded fields, as well as thread-local data, parameterized classes and methods, and protected locks. We also present an algorithm for verifying atomicity via type inference.
 We have applied our type checker and type inference tools to a number of commonly used Java library classes and programs. These tools were able to verify the vast majority of methods in these benchmarks as atomic, indicating that atomicity is a widespread methodology for multithreaded programming. In addition, reported atomicity violations revealed some subtle errors in the synchronization disciplines of these programs.


This study examined the effects of chronic corticosterone (CORT) treatment on the morphology of two physiologically different muscles. Nerve terminals from the slow twitch soleus (SOL) and fast twitch extensor digitorum longus (EDL) of Fischer 344 rats were stained using the zinc iodide osmium (ZIO) technique. Nerve terminal area, perimeter, and logitudinal extent legth were measured using computer‐aided morphometry.


Based on analysis of recognition and writing of Islamic culture and people of the Hui by Zhang Cheng-zhi and Shi Shu-qing,writers of the Hui ethnic group,the author tried to elaborate the similarities and differences from four aspects represented in their writings: Islamic culture,religious belief,people,and aesthetic standard.Shi Shu-qing lived and wrote his works in loess plateau,the holy place of the Hui people.The meaning conveyed in his writings is close to nature of Islam.While Zhang Shang-zhi,based on reason and passion,depicted his approach to holy place artistically,practicing his holy value by aesthetic means.


– A mnemonic for easily recalling the unicode entities of vowels with grave accents, acute accents, and circumflexes is described.


Infrared (IR) small target detection plays an important role in the field of target detection. However, due to the small IR target texture feature is not obvious, low signal-to-noise ratio, strong clutter interference and other reasons, the IR small target detection and its challenges. Therefore, this paper designs a robust detection method which can accurately detect IR dim targets in strong background clutter environment. Firstly, the local mean contrast enhancement strategy is used to enhance the target and suppress the background of the IR image, and the influence of isolated noise is eliminated. Then Harris corner detection algorithm is used to calculate the corner response pixel by pixel for the image after contrast enhancement. Finally, a simple threshold segmentation is used to detect the IR dim small target. The experimental results show that our method has excellent detection effect in the case of very low SCR and strong background clutter. At the same time, compared with the existing methods, our method is more robust and has less false alarm rate.


In this paper, we introduce the concept of smoothness for signals supported on the vertices of a graph. We provide theoretical explanations when and why the Laplacian eigenbasis can be regarded as a meaningful "Fourier" transform of such signals. Moreover, we analyze the desired properties of the underlying graphs for better compressibility of the signals. We verify our theoretical work by experiments on real world data.


The Post-human Potential of a Polish Comic Book Fandom

Comic books are an undeniable part of the modern culture, gaining more popularity every year. Reading comics influences the perception of communing with other products of culture, which results in the transformation of reading into new cultural practices. They may be the result of individual participation, however, the effectiveness of undertakings may often depend on the results of teamwork and collective participation practices. Initially, the grassroots movements of comic book enthusiasts are transformed with time into forms of structured activity. Such an organized community has the potential to implement the assumptions of critical post-humanism, according to which man is not hyper-causative and should participate with actors other than human. This work outlines the historical background of the comic book fandom, considers the idea of participation in culture, analyzes the initiatives taken with particular emphasis on socially engaged activities and content, characterizes the problems faced by the community and relates individual aspects of its functioning to critical post-humanism. The research methodology was based on the analysis of the literature on the subject, virtual ethnology and interviews. The obtained results showed the comic book community as a heterogeneous community that grew out of the need for change. This fandom is involved in initiatives related to diversity, ecology, emancipation and equality, at the same time trying to popularize the comic culture medium.


For parallel robots with general configuration, it is difficult to achieve the large rotation range requirement for pelvic fracture reduction. Application-based workspace optimization is important.In this paper, a 3-RRPS parallel robot with optimized parameters is studied, which can offer large orientation workspace and compact configuration. The inverse kinematics of the robot is analyzed by vector method. The cylindrical coordinate searching algorithm and boundary extraction method is adopted to solve orientation workspace. Defining the comprehensive branch length (CBL) to express robot's compactness under the premise of satisfying the required orientation workspace. The genetic algorithm (GA) is used to optimize structural parameters of the robot with CBL as the objective function. The results show that when the orientation angles of the moving platform are not less than 28°, the optimal CBL of the robot is 291 mm. After virtual prototype simulation verification, the orientation angles of the robot's moving platform around x-axis and y-axis can reach ±28°, the orientation angle around z-axis can reach ±40°, which meets the requirements of rotational range for pelvic fracture reduction surgery.


The influence of activated and acetylaed technology on the production of acetylated wood pulp are investigated.The results show that under the conditions of activated time of 3 h,activated temperature of 80℃,amount of acid as 9 times to that of pulp,acetylated time of 2 h,acetylated temperature of 50℃,amount of sulfuric acid 2.50% and the molar rate of acetic anhydride as 2 times to that of the cellulose's hydroxyl group,the product has good properties with less insoluble residues and fine intrinsic viscosity.


a velocity of pure translation give no appreciable field. If rotation, but not translation, of matter gives a magnetic field, then we should expect the moment of a rotating sphere to be proportional to the volume, so that the field at the equator would be independent of the radius for spheres of the same density and angular velocity.* But it is known that there is no appreciable field due to the rotation of small non-magnetic bodies, so that it seems probable that the earth's field cannot be due to an effect depending on angular velocity only. The Secondary Corpuscular Rays. 455


Abstract : The data from which these records were made were provided by the NASA Goddard Space Flight Center, in digital form, on magnetic tapes. The data tapes contained magnetic field measurements from a three-component Schonstedt Instrument Company fluxgate magnetometer, the time of the measurements, and several other useful related measurements. Each sensor had a nominal range of + or - 1000 gammas in measurement of the magnetic field component along its sensitive axis. One sensor, the Z sensor, was aligned approximately (within 2 degrees) with the spin axis of the satellite throughout the flight.


Abstract New experimental results describing the breakup of drops suddenly subjected to shearing forces sufficient to cause drop breakup are presented. The experiments examine fluids which are immiscible and Newtonian under the conditions studied. These results and other breakup mechanism results are then discussed in the context of combining them with kinematic information on more complex flows in order to predict drop size distributions in processing flows. By analyzing the time scales of various breakage mechanisms studied in simple shear flow and comparing them to the appropriate time scales in more complex flows, the relevant importance of a given mechanism in determining the daughter drop size distribution is predicted. This type of time scale analysis is performed for flow in a cavity and flow in an extruder.


5-Ethyl-2- {4- [4- (4-tetrazol-l-yl - phenoxymethyl) - thiazol-2-yl] - piperidin- 1 -yl} - crystalline salt of a pyrimidine, their composition, methods and methods for their use for their preparation are disclosed. For example, besylate, camsylate, esylate, HBr, HCl, mesylate, is selected from the group consisting of sulfuric acid and tosylate, 5-ethyl-2- {4- [4- (4-tetrazol-1-yl - phenoxymethyl) - thiazol-2-yl] - piperidin- 1 -yl} - crystalline salt of the pyrimidine is provided.


The first 50 years of colonialism in Singapore (beginning in 1819) provided a foundation for the spread of team games that occurred in the second half of the century. The pursuit of athleticism and the games ethic, associated with activities emerging from British Public Schools, would dominate the later sports scene in Singapore. With the added necessity of ensuring health and fitness to combat the tropical environment, games were gradually introduced to other sectors of the predominantly migrant population. This article outlines the evolution of sport (often termed 'amusements' by the British settlers) within the context of rule by the British East India Company. Individual games and recreational pursuits were the rule of the day. The small British and European contingent brought the legacy of country games and traditional sport with them, meaning horse racing, hunting, shooting and to a lesser degree fishing. Not surprisingly sailing proved to be the first systematically organized outdoor activity. Indoor games such as billiards and chess also prevailed. The first organized open-air game was probably fives – a relative of rackets and squash. Some indigenous games were present, notably 'sepak raga' played in a circle form (bulatan). The first sports organized for the general population took place during the New Year festivities, when land and sea sports provided a rare occasion for the people to participate in boisterous fun. The first clubs of any standing emerged in 1826 the Singapore Yacht Club, in 1842 the Sporting Club and in 1852 the Singapore Cricket Club. Association football had yet to be codified in England, so any games of that sort may have included elements of the handling game that was to become rugby. Racket games such as lawn tennis would be introduced in the 1870s. The establishment of modern sports to Singapore can be linked to the early and middle periods of the nineteenth century and as such it would appear that Singapore (along with settlements such as Penang) was a pioneering location for sport in South-East Asia.


In the late 80's, the Portuguese democracy was already a certainty. The official discourse extolled the virtues of the political rulers and the majorities obtained by the PSD and its leader, Cavaco Silva, proved the confidence of voters. However, this scenario was disturbed when the weekly newspaper O Independente reported that the Finance Minister, Miguel Cadilhe, had harmed the State in a real estate business, casting suspicion on the (virtuous) cavaquista governance. Analyzing how this scandal has been built in the pages of O Independente, this paper will reflect on the role of political media scandals in democratic societies, in particular in the Portuguese society over the last twenty years.


The study is aimed to understand multidimensional empowerment framework. It views empowerment as a process having personal, economic, social and political dimensions, with personal empowerment being the 'core' of the empowerment process. The study establishes that MFPs create empowerment promoting conditions for women to move from positions of marginalisation within household decision-making process and exclusion within the community, to one of greater centrality, inclusion and voice. The social processes of MFPs strengthen women's self-esteem and self-worth, instill a greater sense of awareness of social and political issues, leading to increased mobility and reduced traditional seclusion of women. Most importantly, MFPs enable women to contribute to the household economy, increasing their intra-household bargaining power. However, the study recognises the limitations to the transformative capacities of MFPs, especially those operating from a minimalist framework, as economic empowerment doesn't always lead to a reversal in gender relationships.


We consider the problem of simultaneously identifying m intruders in a network consisting of n cooperative agents. Our approach consists of identifying attacks through a distributed scheme that uses detection filters. It is shown that the problem of identifying multiple attackers can be formulated as a spectral assignment problem and that the filter gains can be obtained through a carefully constructed linear system of equations. Necessary and sufficient conditions for the existence of the solution to the linear system are provided in terms of the network topology. The approach is highlighted through an illustrative example.


Rhabdomyosarcoma (RMS) is a mesenchymal cancer of skeletal muscle histogenesis and the most common soft tissue sarcoma of childhood. Survival for children with high-risk disease is less than 30% and has not improved in over four decades, underscoring the need for a deeper understanding of the dysregulated pathways at the molecular level. Recently, we and others have identified Hippo signaling as one of the developmental pathways hijacked by RMS, leading to uncontrolled RMS cell and tumor growth. Here we will describe the nature of dysregulated Hippo signaling in the two most common forms of RMS, known as fusion-negative RMS and fusion-positive RMS (formerly ERMS and ARMS, respectively). Fusion status refers to the absence or presence of RMS-specific PAX-FOXO1 fusion oncogenes, mutant transcription factors that portend a poor clinical outcome. In fusion-negative RMS, we find a critical role for YAP1 in tumor initiation and tumor maintenance, with YAP1 engaged in a feed-forward loop with the Notch pathway to support RMS cancer cell stemness. In fusion-positive RMS, we also find dysregulated canonical Hippo signaling supporting tumorigenic phenotypes. However, there is an additional unanticipated role for PAX3-FOXO1 in restraining noncanonical Hippo signaling. Complementary tumor models used to interrogate Hippo signaling in RMS, including patient-derived cell lines, primary human myoblast-based models, and genetically engineered mouse models, will be presented. Finally, the discrete knowledge gaps to be filled and the therapeutic opportunities that will arise from preclinical harnessing of the Hippo pathway in this and other childhood soft tissue sarcomas will be considered. Citation Format: Corinne M. Linardic. Dysregulated Hippo signaling in childhood rhabdomyosarcoma [abstract]. In: Proceedings of the AACR Special Conference on the Hippo Pathway: Signaling, Cancer, and Beyond; 2019 May 8-11; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2020;18(8_Suppl):Abstract nr IA06.


ECENTLY it has been recognized that there is often a discrepancy between the general reading abilities of the child beginning the study of geography and the specific abilities required to read, with adequate comprehension, introductory textbooks in geography. Though the teacher must normally work with such instructional materials as are at his disposal, he can remove many difficulties by insuring geography readiness on the part of the pupils and by delaying geography instruction until the children are ready for it. The term "geography readiness" (first employed, so far as the writer is aware, by Tabb ') is here used to denote not only readiness for reading in geography but also ability to master geographic concepts and experiences apart from reading. It is the purpose of this article to show that geography readiness can be analyzed and that the study of geography can be planned for intelligently.


Ireland is currently experiencing burgeoning inward investment and economic growth. The ability to attract inward investment is largely due to a well-educated and trained workforce and a rapidly developing innovation culture in the universities and elsewhere. Accordingly, the role of the university has changed radically in the new innovation age because of the heightened strategic importance of education in a society which is now truly knowledge-driven. The ability to exploit new knowledge is intimately linked to the protection of new ideas. Ireland, like most of Europe, lags behind the USA in the area of Intellectual Property Rights (IPR). The authors discuss the importance of redressing this problem as a matter of urgency.