A chromatographic study of fiuorescent substances in the body-surfuce mucus of lyinnaeid snails has shown the existence of a number of ctirointttogruphically distinct forms of Lymnaea peregra. Tho Auorescent patterns of these forms are doscribed arid illustrated and their geographical distribution is mentioned. Evidence of the genetically controlled nature of these patterns is given and tho occurrence of natural hybrids is recorded. The practical uses of the technique in determining the genetic hnogonoily of populations are discussed, also the possible significance of the geographical distribution of the forms.


The invention relates to a low-power shipborne collision early warning method. According to the invention, a low-band VHF radio communication circuit and an antenna are connected at a navigation control terminal through a data interface circuit on a vessel with a navigation function, so that a boat surrounding the vessel is detected; a low-band VHF radio communication circuit, an early warning master controller, a GPS module, a GPRS module, an alarm circuit and an operation display circuit are installed on the boat; the GPS module and the GPRS module are connected with the early warning master controller respectively through ON-OFF control circuits; and the low-band VHF radio communication circuit is connected with the early warning master controller and an antenna through a corresponded interface. The vessel emits signal uninterruptedly to the surrounding area and the boat receives information at intervals; after the information is received, an acousto-optic alarm is emitted and information is sent to the vessel; meanwhile, the GPS module and the GPRS module are started and information is sent to a management center computer; and then the management center computer sends the correlated information to the navigation control terminal of the vessel, so that a good early warning effect is realized.


The paper aimed at analysing the patterns of efficiency of the Lithuanian family farms with respect to the uncertain data. The latter aim was achieved by the virtue of the probabilistic production functions. The sensitivity of the efficiency scores estimated for the Lithuanian family farms was analysed by manipulating the numbers of randomly drawn benchmark observations estimations and thus constructing respective order- m frontiers. The livestock farms appeared to be most efficient, or even super-efficient, independently of the model orientation or the order of the frontier. The crop farms exhibited the lowest mean efficiency as well as the widest distribution of the efficiency scores. The mixed farming was more related to the livestock farming in case of the input–oriented framework and to the crop farming in the output-oriented one in terms of the mean efficiency scores. Thus, the mixed farms were located inside the production frontier (surface) in a rather compact way. JEL codes: C140, C440, D240, Q120.


This article presents a hybrid Abox tableau calculus for SHQ which extends the basic description logic ALC with role hierarchies, transitive roles, and qualified number restrictions. The prominent feature of our hybrid calculus is that it reduces reasoning about qualified number restrictions to integer linear programming. The calculus decides SHQ Abox consistency w.r.t. a Tbox containing general axioms. The presented approach ensures a more informed calculus which adequately handles the interaction between numerical and logical restrictions in SHQ concept and individual descriptions. A prototype reasoner for deciding ALCHQ concept satisfiability has been implemented. An empirical evaluation of our hybrid reasoner and its integrated optimization techniques for a set of synthesized benchmarks featuring qualified number restrictions clearly demonstrates the effectiveness of our hybrid calculus.


The first of the three illustrations should cause no concern. The condition pictured in Fig 1 will respond to proper antipsoriasis therapy. However, Fig 2 and 3 illustrate a condition which requires prompt surgical intervention. The difficulty involved in the clinical distinction between the benign lesion of psoriasis and the malignant lesion of Paget's disease of the nipple is obvious. In Paget's disease of the nipple, the normal epidermal cells are replaced by large, pale-staining cells which lack the normal intercellular attachments of epidermal cells. In addition their cytoplasm stains positively for mucin when the alcianblue technique is used. These pale large cells are malignant in themselves, and are always associated with an underlying mammary carcinoma which is usually of the intraductal type. Presumably, the malignant ductal cells proliferate up the duct and eventually out into the epidermis of the nipple. There they do not form a tumor mass but


To investigate the fatty acids composition in different lactation stages of human milk in China.

 A large cross-sectional study was conducted and lactating women (n = 6481) within 0–330 days postpartum were recruited in China between 2011 and 2013. Human milk sub-samples (n = 1135) were randomly selected for fatty acids analysis in the original study. The sample size of colostrum, transitional milk, and mature milk were 160, 177, 798 respectively. Fats were hydrolyzed and fatty acids methyl esters were analyzed using gas chromatography.

 The content of oleic acid, the highest level fatty acid in human milk, was 36.63%, 34.53% and 35.12% of total fatty acids in colostrum, transitional milk, and mature milk, respectively in China. The content of palmitic acid was about 23.69%, 21.90% and 20.82% in colostrum, transitional milk, and mature milk, respectively. Saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty acids accounted for 36.99%, 39.14% and 23.49% of total fatty acids of mature milk, respectively. The content of linoleic acid and arachidonic acid was 20.47% and 0.54% in mature milk, respectively. The content of eicosapentaenoic acid (EPA) and docosahexenic acid (DHA) was 0.06% and 0.28% in mature milk, respectively. In addition to lactation stage, the fatty acids content differed significantly among various regions, nationalities, or mode of delivery. (i.e., Regions (city vs rural): oleic acid: 33.8% vs 36.4%; linoleic acid: 22.88% vs 17.21%; arachidonic acid:0.64%vs 0.59%; DHA: 0.42% vs 0.26%; EPA: 0.09% vs 0.04%. Nationality (Han vs Minority): oleic acid: 34.40% vs 36.59%; linoleic acid: 21.69% vs 16.54%; arachidonic acid:0.64%vs 0.57%; DHA: 0.38% vs 0.24%; EPA: 0.08% vs 0.04%.).

 Oleic acid is the most abundant fatty acids in human milk of China. In addition to lactation stage, the fatty acid concentrations vary among different regions and nationalities in China.

 This study was supported by Beijing Natural Science Foundation (S160002), the National Key R&D Program of China (2017YFD0400601) and the National High Technology Research and Development Program of China (863 Program) (2010AA023004).


An exoskeleton may help healthy older adults stay independent for a longer time by augmenting their torque at weakened joints. Predictive models are useful to develop exoskeletons and assess the effect of exoskeletons on the user. Existing models that predict the effect of exoskeletons on the user use pre-defined motions which do not change when the forces applied by the exoskeleton changes. In this work we have developed and tested a simulation architecture that incorporates the dynamic interaction between the user and the exoskeleton. This allows to predict modified motions due to the influence of the exoskeleton


This section contains a Greek-Hebrew index of the book An Index to Aquila . The function of this Index to Aquila's version of the Bible is to assist in the major task of obtaining a pre-Massoretic Hebrew text of the Old Testament. It is found that there is a method of cross-reference between the Latin and Greek Index, for in the latter the symbols, lat., syr., arm., are added where appropriate, and in the former the suggested Greek equivalent according to Aquila's method is, if possible, added after the Latin word. Keywords: An Index to Aquila ; Old Testament


Purpose – With the increasing concerns about food management, attention is placed on the monitoring of different potential risk factors for food handling. Therefore, the purpose of this paper is to propose a system that helps facilitate and improve the quality of decision making, reduces the level of substandard goods, and facilitates data capturing and manipulation, to help a warehouses improve quality assurance in the inventory‐receiving process with the support of technology.Design/methodology/approach – This system consists of three modules, which integrate the radio frequency identification (RFID) technology, case‐based reasoning (CBR), and fuzzy reasoning (FR) technique to help monitor food quality assurance activities. In the first module, the data collection module, raw warehouse and work station information are collected. In the second module, the data sorting module, the collected data are stored in a database. In this module, data are decoded, and the coding stored in the RFID tags are transfor...


Literature is replete with robust studies documenting the potential clinical utility and net protective effect of the use of temperature assessment/inflammometry in high-risk diabetic foot. We present a mobile phone-based device (FLIR One Personal Thermal Imager, FLIR, Inc., Wilsonville, OR, USA) and a stand-alone handheld device (Nubee, Duarte California, USA) to provide simple, quantifiable images to assist in rapid clinical visualization. Therefore, the purpose of this manuscript was to highlight the potential day-to-day application of these tools.


Objective To evaluate the diagnostic value of 128-slice spiral computed tomography(128-SCT) for coronary artery disease by compaing with selective X-ray coronary angiography(SCA). Methods Fifty-two cases of coronary artery disease with coronary angiography with CT(CTA)and selective X-ray coronary angiography(SCA) were analyzed retrospectively in order to do comparative analysis. Results 128-SCT coronary artery CTA could obtain better image quality; the coronary CTA imaging detected myocardial bridge in 6 cases, intra-arterial plaques were assessed in 98 branches; 17 cases of coronary artery had advantage. There were 86 branches in coronary artery disease, including 22 with mild stenosis, 24 with moderate stenosis, 40 with severe stenosis. Of 16 cases diagnosed with coronary artery disease by SCA, 22 with mild stenosis, 21 with moderate stenosis, 41 with severe stenosis. Conclusion Compared with SCA, coronary CTA basically can not only indicate the nature of the various plaque pathology, but also judge the stability of plaque and the myocardial bridge, which can be used as the screening for coronary artery disease, being a substitute for diagnostic coronary angiography.


Abstract: The article presents the research results into the influence of the content of a chemical-based stabilizing admixture in the form of starch on the change in the consistency of the concrete mix. The assessment of the impact of the stabilizing admixture dosed in the amount of 0.2%, 0.4%, and 0.6% in relation to the mass of cement on the change in consistency was made based on the cone drop test according to PN-EN 12350-2:2019-07. From the prepared concrete mixes, samples were also made for testing concrete density according to PN-EN 12390-7:2019-08 and compressive strength according to PN-EN 12390- 3:2019-07. For the developed composition of the concrete mix, a standard (reference) mix was prepared, which was used to compare the test results from samples containing admixture in different amounts. Based on the tests carried out, it was found that the applied stabilizing admixture based on starch with a different percentage share concerning the mass of cement significantly reduces the consistency. The use of an admixture in the case of a concrete mix with too high consistency gives the possibility of changing its purpose without affecting the other parameters. Keywords: Concrete mix; Starch; Concrete consistency


It is required for the Chinese insurance market to setup evaluating system of insurance. The core of it is the evaluating system of policies. It can make the policies understood easy. It is urgent to setup evaluating system of life insurance policies because the life policies have great effect to everyone and the most revenue of premium is from life policies. The key factors of the evaluating system for life policies are guarantee, increment and service. The main content of this article is about evaluating system of the guarantee of life policies.


Carrying out the freedom of the government information is not only the trend of times,but the inevitable requirement of modern society to the government. Based on the necessity,the paper gives objective estimation of Chinese government information freedom and offers measures to promote and perform the situation.


Teenage pregnancy have a higher risk, not only damage the future of teenagers are concerned but also very dangerous for the health of adolescents. Antenatal Care (ANC) is a planned program of observation, education, and medical treatent in pregnant woman. ANC purpose in to monitor the progress of pregnancy, ensuring health and infant growth and development as well as improving and maintaining physical, mental, and social mother and baby. Antenatal Care behavior is determined by several factors, including predisposing factor, enabling factor, and reinforcing factor.To analyze the determinants of antenatal care on behavior of teenage pregnancy in the region Karanglewas health center Banyumas Residence 2014.The kind of reaserch is descriptive analytic with cross sectional approach. Taking into 43 teenage pregnancy third trimester. The sample taking technique used total sampling method. The analyze used the chi square and logistic regression. The majority education of teenage pregnant is elementary education (81.4%). The majority knowledge of teenage pregnant is good (60.5%). The majority attitude of teenage pregnancy mother's is good (60.5%). The majority behavior of teenage pregnancy is good  (81.4%). There is no correlation between education and behavior of Antenatal Care (p = 0,623 > = 0,05). There is a correlation between knowledge and behavior of Antenatal Care (p = 0,042 < = 0,05). There is a correlation between attitude and behavior of Antenatal Care (p = 0,042 < = 0,05). And the most factor that influence ANC behavior are knowledge and attitude (OR = 0,018). Keyword : Education, knowledge, attitude, behavior of ANC


Dam-break flood wave is an irregular, time-dependent and rapidly varying free surface open channel flow and therefore, is one of the complex and difficult problems. The research for solving this problem is mainly directed at experimental and numerical studies due to the difficulties in collecting field data. Despite that, the experimental and numerical studies on 3-dimensional dam-break problem are limited in the literature. In this study, the propagation of expanding dam-break flood wave in the downstream direction is investigated using a vertical plate placed in front of a reservoir built in the laboratory. The propagation of the wave front was observed using high speed camera and obtained results were compared with FLOW-3D numerical model which uses 3D RANS equations. The results were in quite good agreement.


For getting the accurately coal gas concentration, according to the its nonlinear characteristics and time series chaotic characteristics, established a forecasting model, using chaos theory and RBF neural network. To get the training samples, it reconstructed gas concentration time series. Using MATLAB simulation to forecast analysis, the result shows that the relative prediction error is from 0 to 3%, and the mean square error is 0.0056. The result is well, and the examples show prediction model is feasible.


An udder health programme (either at farm level or in a wider, industry level context) will only be effective if it is communicated in such a way that on-farm compliance is maximised. This requires an understanding of the varying aspects which motivate different farmers to implement change: while many other elements have been shown to be important, economic justification is a highly powerful driver of change in many herds. A good understanding of the costs of both clinical and subclinical disease is critical in understanding the potential for and likelihood of cost-benefit as a result of implementation of specific udder health measures.


The actual radial clearance and runout of the bearing are different from design ones, because of the unavoidable raceway roundness and roller diameter errors of a cylindrical roller bearing. However, there is little knowledge about how the raceway roundness and roller diameter errors affect the radial clearance due to the lack of the analysis method. In this study, a mathematic model with algebraic equations is developed. The raceway curves are described by Fourier series. When the outer ring is turned a angle, iterative calculations are done until at least one roller contacts the raceways by judging whether the clearances between the rollers and inner raceway equal zero or not. Then the radial clearance and runout of the bearing can be determined when the outer ring is turned one revolution. The independent and synthetic effects of the raceway roundness and roller diameter errors on the radial clearance and runout of a cylindrical roller bearing are analyzed. Results show that the clearance and runout periodically vary with the increase of the flap number, which is also the harmonic number, of the rotating raceway. The ratio of the numbers of the raceway flaps and rollers determines the period. The clearance and runout of a cylindrical roller bearing are greatly affected by the rollers' diameter errors instead of their positions.


Fatal bacteremic Klebsiella pneumoniae pneumonia is commonly encountered in alcoholic and diabetic patients. This report describes a previously healthy young man with rapidly fatal bacteremic pneumonia caused by K. pneumoniae serotype K1, complicated by septic shock and multiple organ dysfunction.


Contrary to what critics suggest, there is abundant evidence that high quality, gradeseparated transit does reduce urban traffic congestion. For example, research by Winston and Langer (2004) indicates that both motorist and truck congestion costs decline in a city as rail transit mileage expands. Garrett (2004) found that traffic congestion growth rates declined in several U.S. cities after light rail service was established. Baum-Snow and Kahn (2005) found significantly lower average commute travel times in areas near rail transit than in otherwise comparable locations that lack rail, due to rails higher travel speeds compared with automobile or bus under the same conditions. Using a regional traffic model Nelson, et al (2006) found that Washington DC's Metro rail transit service generates congestion-reduction benefits that exceed subsidies. My own research (Litman, 2004) shows that per capita congestion delay is significantly lower in cities with high quality rail transit systems than in otherwise comparable cities with little or no rail service. These results hold true even if New York is excluded from the analysis.


1. Euclid, The Thirteen Books of the Elements (trans, with introduction and commentary by T. L. Heath), 2nd ed., vol. 1 (Books I-II), vol. 2 (Books III-IX), vol. 3 (Books X-XIII), Dover, New York, 1956. 2. G. P?lya, Mathematics and Plausible Reasoning, vol. 1 (reprint of the 1954 original), Princeton University Press, Princeton, 1990. 3. R. Dedekind, Essays on the Theory of Numbers, I: Continuity and Irrational Numbers, II .The Nature and Meaning of Numbers (trans. W. W. Beman), Dover, New York, 1963.


Background: Due to strict time management General Practitioners (GPs) prefer short instruments when identifying suicidal behaviour in their patients. We summarize the available studies reporting diagnostic accuracy of brief instruments for suicidal behaviour in primary care. Method: Databases MEDLINE, EMBASE, PsychINFO, PSYNDEX, and Cochrane Library were searched without any time constraints. Risk of bias and applicability concerns were assessed using the QUADAS-2 tool. The certainty of evidence was rated via GRADEpro. We included studies on primary care patients or participants from the general population. Suicidal behaviour was the defined target condition. With respect to the applicability in a primary care setting we included only studies assessing brief screening instruments; a brief instrument was defined as having no more than twelve items. We assessed sensitivity, specificity, and positive and negative predictive value. Results: A total of 9,969 studies was identified; of those, six fulfilled all strong criteria and were included. The range of sensitivity was 0.26-1.00, specificity was 0.64-0.99, positive predictive value 0.06-0.91, negative predictive value 0.86-1.00. Risk of bias was rated moderate and concerns regarding applicability acceptable. A required sensitivity of at least 0.80 and specificity of 0.50 with a moderate to high GRADE rating was achieved by six of nine index tests. Conclusions: Brief screening instruments can support ruling-out suicidality, but are less suitable for ruling-in. They may support GPs in an initial assessment, but in case of a positive test result, a valid diagnostic assessment should be done by a structured clinical interview.


Objectives:Fmoc solid phase peptide synthesis principle was used to synthesize MP-2 and the anti - tuomr activity of MP-2 was checked.Methods:MP-2 was synthesized by PSSM -8 automatic peptide synthesiz- er,experimental factors were optimized by orthogonal experiment,peptide -resins were cleaved by trifluoroacetie acid (TFA),crude peptides were assessed by LC -MS and purified by HPLC.The purified MP-2 was farther eharacteried by conti-furneor assay.Results:Reaction conditions of synthesis were optimized with a purity of more than 69.2% and a recovery yield of 82%,which was checked by HPLC.The crude peptides were purified by pre- parative medium performance liquid chromatography (MPLC) and the purity of products reached more than 95%. The anti -tumor activity of MP-2 was evaluated on Km mice bearing S180 tumor,and the optimum dose of 0.25 mg·kg~(-1) was determined,the inhibition of tumor growth could reach 50.4%,a little lower than cyclophosphamide group.But MP-2 showed no side effect on mice's growth.Conclusions:With simple process,but high productivity and high purity,Fmoc principle was found to be a perfect method to synthesize MP -2,and the purity of products that purified by MPLC was high.Paper showed that MP -2 could suppress the growth of S180 efficiently,and set foundation for further pharmacodynamic research.


The usage of endodermic layers of melon (Cucumis melo L) to make succade have texture limitation. Blanching as a part of succade processing can make collapse texture of succade. To limitation the collapse texture need need soaking in firming agent solution like CaCl2, Ca(OH)2 and CaC6H10O6.5H2O. The usage of different calcium salt types will produce hygroscopicity differences which have effect to succade characteristic during storage. The experimental design is Nested Factorial Block Design. These are consist of two factors, the storage period (0, 1, 2, 3, 4 and 5 weeks) nested in the types of calcium salts (CaCl2, CaC6H10O6.5H2O and Ca(OH)2). Each treatment will be repeated three-times and tested parameter are water content, hardness, colour and organoleptic test (different test .i.e. performance, crispness and toughness). The data which obtained were analyzed with ANOVA (Analysis of Varians) at α = 5% then followed by Duncan's Multiple Range Test at α = 5% to find the degree of treatment which was really different. The experiment showed that calcium salts types influence the water content and shrinkage degree, whereas storage period of each calcium salts types influence the water content, hardness, colour (lightness, yellowness and redness) and organoleptic (crispness and white patch). Succade which were soaked in CaCl2 or calcium lactate solution showed the increasing of water content during five weeks storage, which cause the increasing of tenderness, lightness, yellowness and decreasing of redness, crispness and white patch. Succade which soaked in Ca(OH)2 solution during five weeks storage showed insignificant of increased water content and decreasing of water content in second week which result the increasing of hardness, redness, white patch and decreasing of lightness and yellowness.


The exchange of health information in conditions directly related to electronic environment is referred as health information technology. Usually the protection of personal health related data is comprised of various elements such as ways of information usage and access to sensitive health information. The protection of individually identifiable health information is possible with combination of measures. Protective measures include administrative, technical and physical elements. Through such protective measures is possible to ensure confidentiality, integrity and availability of the information, while at the same time could be guaranteed the prevention of unauthorized access. Sensitive records usually contain personal health information. Personal medical data requires high level of protection, as its content includes medical condition or diagnosis, where unauthorized access could have negative impact on one's personal and professional life.


A death following epidural anaesthesia for Caesarean section in a patient with aortic incompetence and pre‐eclampsia is described. Possible hazards of epidural anaesthesia in aortic incompetence are described and it is suggested that reduction of total peripheral resistance is contraindicated in such patients.


Objective:To explore the psychological state of convalescent patients with senile depression and social support system.Methods:SCL-90 Symptom Checklist,Perceived Social Support Scale(PSSS),rehabilitation of 75 cases of senile depression were investigated and the findings of SCL-90 were analyzed with the norm.Results:The SCL-90 factor analysis,the rehabilitation of patients with senile depression in the somatization,interpersonal sensitivity,depression,anxiety,terror,mental illness and other factors were significantly higher than the norm.PSSS score of 30.58±12.16,accounting for 81.33% of low support for the state.Conclusion:Convalescent patients with senile depression obvious psychological problems,lack of social support system.


Abstract Background: Little is known about the growth rate of cholesteatoma in patients. Objective: Investigate the growth of residual cholesteatoma in subtotal petrosectomy based on volume measured in MRI scans. Materials and methods: Retrospective case series in a Tertiary Medical Centre. Thirteen residual cholesteatomas were identified in 10 patients after subtotal petrosectomy for which a wait-and-scan policy was adopted. Volume of the residual cholesteatoma was calculated by manual segmentation as well as the 'box method'. Results: Mean growth rate was 27.9 mm3/month (SD 22.8), with a large individual variation ranging from 2.2 to 69.8 mm3/month. No complications were reported in 10 patients with a wait-and-scan policy for residual cholesteatoma in subtotal petrosectomy. The box method overestimates growth rate compared to the reference method manual segmentation and a linear increase of this systematic error was seen with increasing size of the cholesteatoma. Conclusions: Residual cholesteatoma growth rate shows a large individual variation. A wait-and-scan policy could be considered in case of a (small) residual in subtotal petrosectomy with ample room to grow before destroying any remaining structures. Furthermore, the clinically more applicable and less time-consuming box method can be used to accurately measure volumes of small cholesteatomasup to a volume of 500 mm3.


The political overtones of Luigi Nono's works often resonate more loudly than his music. One might be tempted to counteract the eclipse of musical issues by social issues through reversing the position i.e., discussing music to the exclusion of politics but such a reversal might not be any more fruitful for the study of socially engaged artworks such as Nono's. Rather than posit musical and social issues at opposite poles of a hypothetical spectrum, I shall attempt to present both side by side, as analogous realms that exhibit identifiably similar tendencies. In the same vein, I shall place Nono's music in analogous but not opposite musical contexts. Even though this essay was originally presented in a conference session devoted to so-called avant-garde music composed after the Second World War, I will orient my discussion around sacred music composed before the Thirty Years War.


Detailed measurements of rocks in the far field at the Mars Pathfinder landing site are consistent with the near field exponential drop off in the cumulative number or area covered by large diameter rocks (and with similar behavior at the Viking sites).


Any pathological process is accompanied by quantitative and qualitative changes in metabolism, which is the main form of life manifestation. Metabolism disorders (it is the permanent exchange of substances between the body and the environment) arise if the activity of the central nervous system is affected; the trophic function of the nervous system directs nutrition and metabolism. In this function, the coordinating role belongs to the central nervous system and is made by means of the endocrine glands. Lipids introduced into the body are digested mainly with the help of the pancreatic and intestinal juice and are resorbed through the walls of the small intestine. Even in the intestinal wall, the re-synthesis of fatty acids and glycerine fat occurs. A certain amount of neutral fat is probably resorbed without being split into fatty acids and glycerine. Fats are mainly resorbed through the lymphatic system, in part (about 30%) by means of the portal vein system; the entire fat emulsion penetrates into the blood and its main mass is deposited in certain fat deposits: the adipose subcutaneous cell tissue, the epiploon and the mesenterium of the abdominal cavity, as well as in the fatty layers of the various organs. In fat deposits, processes of lipid formation from carbohydrates and of transformation of higher fatty acids can occur. Lipids from fat deposits are subject to oxidation, especially at the liver level.

https://revistadechimie.ro/pdf/70  PLESEA 7 19.pdf


The quantification of the impact of crises on household welfare and socioeconomic outcomes is a fundamental input for the design of ex ante safety nets and ex post alleviation programs. Economic downturns have direct effects through employment and household income, but whether these and other impacts are permanent rather than transitory is harder to establish. This study of Argentina estimates the relationship between GDP growth and severe crises on poverty, youth unemployment, and a series of human capital related outcomes, such as infant and maternal health, and school enrollment and progression. The identification strategy relies on provincial variation in GDP, and on a difference in differences estimation from the severe 1999-2002 crisis. The objective is twofold. On the one hand, the study documents the effects of past episodes. On the other hand, it extrapolates past results to provide bounds for the impact of the 2007-2009 financial crisis in Argentina. Besides the expected and well-documented relationship between crises and poverty levels, the main finding of this study is a strong effect on infant mortality and low weight at birth. Moreover, there is an asymmetry in these effects: the negative impact of downturns is greater than the positive evolution during recoveries. The results for education variables are more ambiguous, and even counter-cyclical in some cases. The document discusses the implications of these estimates for the current episode. Overall, these results provide evidence of permanent effects of economic crises through lower levels of human capital, worsening health outcomes and increased mortality. 1 The authors wish to thank Norbert Schady for detailed comments and suggestions, as well as Leonardo Gasparini, Andres Ham and participants at the UNDP-Regional Bureau for Latin America and the Caribbean seminars in Sao Paolo and Mexico City. The opinions in this document correspond to those of its authors, and do not necessarily represent those of the institutions to which they belong. Corresponding author: firstname.lastname@example.com CEDLAS-UNLP. Centro de Estudios Distributivos, Laborales y Sociales, Facultad de Ciencias Economicas, Universidad Nacional de La Plata. Calle 6 entre 47 y 48, 5to. piso, oficina 516, (1900) La Plata, Argentina. Phone: +54-(221)-422-9383. Email: email@example.com Website: www.cedlas.org


272 Background: Readmission within 30 days of discharge has been perceived by the Centers for Medicare and Medicaid Services to be an indicator of poor healthcare quality, however it is unclear how accurately this applies to oncology patients. Patients treated with allogeneic hematopoietic stem cell transplantation (HSCT) have high rates of readmission, but the incidence following umbilical cord blood transplantation (UCBT) is poorly described. The goal of this study was to identify the incidence, reasons, and risk factors for readmission following UCBT.

METHODS
A retrospective review of patients receiving an UCBT at Dana-Farber/Brigham and Women's Hospital between January 1, 2004 and December 31, 2013 was performed. The 30-day and the day +100, a traditional assessment point in transplantation, readmission rates were examined. Reasons for readmission, as well as sociodemographic and disease and stem cell transplant related variables were evaluated. Predictors of readmission were identified using multivariate regression analysis.

RESULTS
33.6% (42/125) of patients were readmitted within 30 days of discharge. Of patients who survived until day +100, 46.7% (57/122) were readmitted within 100 days of UCBT. The most common cause for readmission was infection (38.3%), followed by fever without a source (14.8%) and graft vs. host disease (GVHD) (8.6%) (Table). A multivariate logistic regression model of the probability of being readmitted within 30 days and by day +100 suggested that infection during transplant admission was a significant risk factor for readmission (OR: 5.1, p=0.003 and OR: 2.9, p=0.014, respectively).

CONCLUSIONS
There is a high rate of readmission within 30 days and by day +100 following UCBT. The most common causes of readmission were infection and fever without a source. Infection during the transplant admission predicted a higher risk of readmission, suggesting a possible group to target for interventions aimed at reducing readmissions and improving quality of care. [Table: see text].


Research to correlate bearing remaining useful life (RUL) predictions with Helicopter Health Usage Monitoring Systems (HUMS) condition indicators (CI) to indicate the damage state of a transmission component has been developed. Condition indicators were monitored and recorded on UH-60M (Black Hawk) tail gearbox output shaft thrust bearings, which had been removed from helicopters and installed in a bearing spall propagation test rig. Condition indicators monitoring the tail gearbox output shaft thrust bearings in UH-60M helicopters were also recorded from an on-board HUMS. The spal-lpropagation data collected in the test rig was used to generate condition indicators for bearing fault detection. A damage progression model was also developed from this data. Determining the RUL of this component in a helicopter requires the CI response to be mapped to the damage state. The data from helicopters and a test rig were analyzed to determine if bearing remaining useful life predictions could be correlated with HUMS condition indicators (CI). Results indicate data fusion analysis techniques can be used to map the CI response to the damage levels.


Endothelial cells distinguished by their epithelioid morphology have been recognized for many years. Rosai first characterized them as "histiocytoid" in appearance in 1979 and soon thereafter they became known by the more popularized term "epithelioid". By the early and mid 1980's this nomenclature was incorporated into classification schemes of epithelioid vascular tumors that included reactive, benign and malignant proliferations such as variants of bacillary angiomatosis, epithelioid hemangioma, spindle cell hemangioma, epithelioid hemangioendothelioma and epithelioid angiosarcoma. Subsequently, several new uncommon entities including composite hemangioendothelioma and epithelioid sarcoma-like hemangioendothelioma were described. As a group, these tumors can originate in a variety of different organ systems however, most develop in the soft tissues and skeleton. The epithelioid endothelial cell is common to them all, however, it is very important to distinguish amongst them as they have significant differences in their clinical behavior and biological potential and consequently their treatment and prognosis.


OBJECTIVE:To investigate the therapeutic efficacy of polycystic ovary syndrome(PCOS)in the treatment of Ethinylestradiol and cyproterone acetate tablets.METHODS:62 cases of PCOS were treated by Ethinylestradiol and cyproterone acetate tablets for 3 cycles.The serum levels of E2,FSH,LH,PRL and T,the size of ovary and the number of sinus follicle were determined before and after treatment(P0.01 or P0.05).RESULTS:The serum levels of FSH,LH,LH/FSH,T and PRL and the size of ovary and the number of sinus follicle decreased significantly after treatment for 3 cycles than before(all P0.01).CONCLUSION:Ethinylestradiol and cyproterone acetate tablets can significantly improve hyperandrogenism in PCOS patient and be used for ovulation induction so as to promote the possibility of ovulation and pregnancy.


"Since the Beginning Pemuda Pancasila has always Supported Reformasi carried out Constitutionally. The Coverage by the Print Media and the Electronic Media of Pemuda Pancasila's presence at the DPR RI on May 19 1998 is Mistaken and Without a Clear Source." So read the banner which hung in "strategic locations" in each of Jakarta's five boroughs within two days of Suharto's resignation. However, on May 21, two days before the banners went up and the evening after Suharto delivered his short statement of abdication, the confusion at Pemuda Pancasila [PP] HQ had yet to be so institutionalized. "There's been a bad misunderstanding," pleaded a shaken Alwi, in lieu of a salutation. He went on in defense of his organization, insisting it wasn't members of PP who brought the sign reading "The President of Indonesia Remains Haji M. Suharto" to the DPR [People's Representative Assembly], but rather it was FKPPI2 that brought the sign. FKPPI had left their banner behind and some Pemuda Pancasila members just happened to pick it up. If they were caught before the cameras holding the banner, that was only because some of our members are under-educated and didn't think to read the sign first, explained Alwi, a Pemuda Pancasila member who once staffed the cigarette stand outside the youth group's HQ in front of the Tebet train station in South Jakarta.


The environment perception technology is the difficult problem for Unmaned Ground Vehicles navigation,especially under off-road conditions.As is known,off-road environment appears changeable and there are several kinds of obstacles,including water,stone or steep slope,bush or shrub,deep ditch and trees,etc.In this paper various typical obstacles were picked by using LMS Z210 laser range finder.UGV following road image were acquired with the size of 80×30.Since different obstacle had distinct characteristic from laser image,laser beams hitting water surface at an oblique angle were reflected away from the sensor,resulting in the fact that no data were returned.Such points showed up as voids in the laser image.Based on this,water area could be detected effectively.According to different features of other obstacles,stones and trees were both recognized accurately.On the basis of horizontal projection and vertical projection theory,the 3D information of detected obstacle was calculated.It will make firm foundation for 3D reconstruction.


One of the parameter to judge the success of an university is the quality of the
alumnus product appearance in answering the challenge of the real world, either they
choose professional line or education and academic line. Although like this, the mismatch
can be happened between the graduate capability with the real world demand, if the
factors outside education aspects like personal aspect or external factors beyond the
reach of the education world.
The background of this learning and teaching method is the problems that have
been faced by the freshly graduate students as a result of the existing architectural
education, The architectural education now and in tile future should be capable to
produce ready-use graduates and capable to struggle in the global world that has been
waiting for them. This ' thing can be achieve by learning method that introduce real
entrepreneur or business world in the early stage.
One of the solution is by developing learning method in the architectural
department using "Design and Sell" method, the metnod that give chances to the
students to know more about the working world and the real world.


within globalization. Nonetheless, the term "community" does carry with it the implication of some degree of value consensus or, more weakly, of some shared meanings, shared rules, and shared institutions. Common meanings are, after all, the basis and bedrock of any understanding of community. Yes, we can trace the ever-increasing density of integration, exchange, and communication and the increasing activism of transnational civil society. But to what extent and in what precise ways does this provide evidence of a global community characterized by shared understandings and shared rules and institutions? This is perhaps the most important question raised, but not fully answered, by Iriye's fascinating book.


Diamond nanocrystals are deterministically positioned on high-Q SiO2 microdisks using a fiber taper. The fiber taper is then used to collect cavity modified NV- nanocrystal emission.


We demonstrate that the Hamiltonian structure and the integrability of a system of evolution equations can be formulated in terms of a classical field theory using BRST and anti-BRST symmetries. We derive the field theory action and explicitly generate the integrable hierarchy associated to a bi-Hamiltonian system based on cohomological arguments and gauge-fixing deformations.


Cost efficient operation and maintenance strategies are crucial for reducing cost of wind energy. Since the regime change from feed-in tariffs to an auction-based bidding system for capacity in mos ...


The mystery illness known as SARS n-Cov2 COVID-19 has revolutionized the lives of people irrespective of their age group; it has brought everything to a standstill. Lockdown was imposed which exacerbated the anxiety levels. It has to a great extent affected the physical and mental health of the masses across the globe.This quantitative and qualitative interpretative research aims to examine the level of anxiety among 251 college and university students studying in various universities and colleges across the Kashmir division of Jammu and Kashmir, India. The study was conducted in July 2020 when the lockdown was strictly in action. Convenience sampling was used to collect the data. This Study administered a questionnaire known as Generalised Anxiety Disorder Screener (GAD -7), an anxiety questionnaire which is self-reported to find out the anxiety level among students, and thematic analysis was used initially to measure the coping mechanism before the extracted code were put in frames. It was found out that most student's experienced moderate and severe anxiety due to the COVID-19 pandemic and the subsequent lockdown.Thematic data analysis outcome indicated five major themes-Developments of Personal interest, Putative coping, Religious Coping,Gaming and Maladaptive coping strategies. This research study discovered that students tried to mitigate stress but were mostly found aimless and the stance for handling such an uninvited situation wasn't clear. However, more research is required to investigate anxiety levels among students. Keyword: Anxiety, COVID-19, Coping, University Students, Religious Coping.


The development and optical spectral analysis of Cu 2+ (0.5 mol %) doped three new glasses have been reported in the following composition: 10TeO 2 -69.5 B 2 O 3 -10 Li 2 O-10 AlF 3 ; 10CdO-69.5 B 2 O 3 -10 Li 2 O-10 AlF 3 ; 10ZnO-69.5 B 2 O 3 -10 Li 2 O-10 AlF 3 . Due to the homogeneous distribution of Cu 2+ ions, both CdO and ZnO containing glasses are found to be in bright blue colour, but a greenish blue colour has been noticed from the TeO 2 containing glass, the reason for this has been explained. Without the Cu 2+ ions, the reference glasses have also been prepared and found them in good transparency with excellent resistance towards the moisture without any degradation on their surfaces. Based on the XRD profiles, amorphous nature of these glasses has been confirmed. Due to the presence of TeO 2 , the UV transmission for the glass is found to be extended up to 300 nm compared with the other two glasses. Under an UV source (254 nm), a blue emission has been noticed from the surfaces of the glasses. From the measured absorption spectra of these copper glasses, a abroad absorption band ( 2 B 1g → 2 B 2g ) at 800 nm and a weak absorption band ( 2 B 1g → 2 E g ) at 387 nm have been measured to examine the effects of the CdO, ZnO and TeO 2 contents in the glasses studied. FTIR spectra of these glasses have also been analyzed to investigate the glass structures. Emission spectra of (0.5 mol %) Cu 2+ : B 2 O 3 -(TeO 2 /CdO/ZnO)-Li 2 O-AlF3 have revealed two emissions at 415 and 438 nm with an excitation at 371nm.


The invention relates to a solvent composition for cleaning, and particularly relates to a cleaning solvent composition for an automobile coating line. The cleaning solvent composition comprises C1-4 fatty acids, C1-6 alkyl esters, C1-4 alkyl alcohols and C3-8 alkyl ketones. The cleaning solvent composition has the characteristics of being high in flash point, and excellent in cleaning property.


This study is purposed to analyze the economic impact of the Mega Sports event on the region by means of the Inter Regional Input Output Analysis in these viewpoints. As a method of study, the tourism industry was re-classified into wholesale and retail business, food business, accommodation and culture amusement service in two inter regional industry relation tables composed of Gangwon-do and Non Gangwon-do, and the economic impact distributed to the district owing to the holding of the ``2010 Chuncheon World Leisure Congress and Leisure Games`` was analyzed by deriving the tourism multiplier, When the economic impact distributed directly and indirectly to the economy of Chunchoen was analyzed, about 45.38 billion Won of production induced effect, about 24.01 billion Won of added value induced, about 8.62 billion Won of income induced effect and about 1,010 employment induced effect had been appeared.


1. Michael Robert Herman, 1942-2000 A. Fathi and J. C. Yoccoz 2. L2 regularity of measurable solutions of a finite-difference equation of the circle Michael Robert Herman 3. On Herman's theorem for ergodic, amenable group extensions of endomorphisms Jon Aaronson and Benjamin Weiss 4. Lyapunov exponents with multiplicity 1 for deterministic products of matrices C. Bonnati and M. Viana 5. Remarks on stability and diffusion in high-dimensional Hamiltonian systems and partial differential equations Jean Bourgain 6. Stable manifolds and the Perron-Irwin method Marc Chaperon 7. C2 densely the 2-sphere has an elliptic closed geodesic Gonzalo Contreras and Fernando Oliveira 8. Further rigidity properties of conformal Anosov systems R. De La Lave 9. On some approximation of the 3D Euler system E. I. Dinaburg and Ya G. Sinai 10. Lyapunov 1-forms for flows M. Farber, T. Kappeler, J. Latschev and E. Zehnder 11. Constructions in elliptic dynamics Bassam Fayad and Anatole Katok 12. Demonstration du 'theoreme d'Arnold' sur la stabilite du systeme planetaire (d'apres Herman) Jacques Fejoz 13. Sur le theoreme de Bertrand (d'apres Michael Herman) Jacques Fejoz and Laurent Kaczmarek 14. Commutators and diffeomorphisms of surfaces Jean-Marc Gambaudo and Etienne Ghys 15. Wandering domains and random walks in Gevrey near-integrable systems Jean-Pierre Marco and David Sauzin 16. Examples of Aubry sets John N. Mather 17. New phenomena associated with homoclinic tangencies Sheldon E. Newhouse 18. On holomorphic critical quasi-circle maps Carsten Lunde Petersen 19. KAM theorem for Gevrey Hamiltonians G. Popov 20. Convergent transformations into a normal form in analytic Hamiltonian systems with two degrees of freedom on the zero energy surface near degenerate elliptic singularities Helmut Russmann 21. Sur les structures de Poisson singulieres Laurent Stolovitch.


Let G be a finite group. A normal subgroup N of G is a union of several G-conjugacy classes, and it is called n-decomposable in G if it is a union of n distinct G-conjugacy classes. In this paper, we first classify finite non-perfect groups satisfying the condition that the numbers of conjugacy classes contained in its non-trivial normal subgroups are two consecutive positive integers, and we later prove that there is no non-perfect group such that the numbers of conjugacy classes contained in its non-trivial normal subgroups are 2, 3, 4 and 5.


Horizontal stratified strata is a common geological model, and it needs to be simulated numerically in order to get the propagation law of sound waves in it, usually using the finite-difference time-domain method. However, for hundreds of meters underground well section, how to improve the calculation efficiency is a question that we need consider. In this paper, a dynamic method is proposed to obtain the computational domain, which can minimize the computational domain when the simulation results are reliable. When the transmitter is located below the receiver and the nearest delamination boundary is more than 2.0 m below the instrument, all delamination media below the instrument can be ignored in the calculation. A similar strategy is used for the layered boundary located above the array receiver. In this paper, the method is used to simulate the response of phased array acoustic logging in multi-layer media.


This article introduces proximal̆ Cech complexes in approximating object shapes in digital ima ges. The theoretical framework is based on̆ Cech complexes and proximity spaces. Several topological st ructures are defined for the C̆ech nerve based covers of a finite region of Euclidean plane. W e definek-petals andk-corollas which are the generalizations of spokes and maximal nuclear clusters. We extend the classical notion of a proximity as a binary relation, to arbitrary number of sets. A new shape signature based on the distribution of orders of C̆ech nerves is defined. A practical application of this framework in approx imating object shapes in digital images is given.


Ultraviolet Rays to glaze is popular in recent years by its unique superiority,it becomes the important method of enhances the print extra value. Ultraviolet Rays to glaze such as the ice flower,refractive power,crystal seven colors and so on not only impact vision,but also impact smell and touch,which causes the ordinary printed matter promotion to the high-quality goods. This article through discussion about esthetic value and application of Ultraviolet Rays to glaze in printed matter design,prospect reknew Ultraviolet Rays,and also expect to pay close attention to other special printing.


In this paper, we propose and analyze a direct sequence spread spectrum multiaccess (DS/CDMA) receiver that employs an integrated filtering and decoding technique for cancellation of cochannel interference (CCI) in cascaded form. We consider channels that experience multipath returns which is one of the factors responsible for signal degradation in mobile communication systems. The idea behind the integrated filtering is that CCI can be more reliably estimated by exploiting coding. We investigate the BER performance of the proposed scheme by theoretical analysis. Both numerical and simulation results exhibit the significant improvement that can be attained by the proposed scheme compared to the conventional scheme.<<ETX>>


The study analyses the implementation of TOEFL Preparation and provides conclusions and suggestions to improve participants' ability to face the TOEFL test. In the study, 40 participants participated in the implementation of TOEFL preparation courses which consisted of three parts, namely listening, structure, and reading. The analysis results showed that the average TOEFL score of the participants was 448, with the highest score reaching 540 and the lowest score of 376. Although the average score met the minimum requirements at IBIK 57 Campus, there were participants who did not reach the standard. Suggestions included individual coaching, increased listening practice, strengthened knowledge of grammar and structure, reading comprehension strategies, as well as encouragement for self-study and use of additional resources.


Self-pumped phase conjugate wave has been observed in KNSBN:Co crystal at different argon-ion laser wavelengths. For 514.5 nm of the wavelengths, phase conjugate reflectivity as high as 73.0% is measured. The incident angle and incident position dependence of phase conjugate reflectivity is presented. The formation time is observed to be dependent on the incident intensity. The loss of the crystal is regarded connected with threshold intensity of producing self-pumped phase conjugation.


There is a theory error in the electro-hydraulic servo valve frequency characteristic test system due to the presence of dynamic flow meter piston position feedback system.With the help of computer simulation,the degree and variations of the error can be rationally analyzed.According to an example of the electro-hydraulic servo valve frequency characteristic test system,the test error can be analyzed by the Simulink function of software Matlab.The results have proved that by adjusting the gain and time coefficient of the inertia link in the feedback system based on the frequency range of the tested servo valve,a higher test precision of the servo valve frequency characteristic will been obtained.


Low‐temperature (T=50 K) Raman rotational spectra are calculated for the endohedral complexes Li+@C60, Na+@C60, CO@C60, LiF@C60, and LiH@C60. The systems Na+@C60 and CO@C60 produce very similar spectra dominated by pure rotational bands. The other systems present more complex and dissimilar spectra which suggest librational motions and hindered rotations. An assignment of these spectra is provided by analyzing the structure of the low energy rotational eigenvalues and eigenfunctions. Rotational energy quasiband and quasiresonance‐band structures are found to be the origin of the features observed in the more complex spectra. Out of these analyses, a classification of the low‐temperature rotational spectra of endohedral C60 complexes in two basic classes emerges.


In the LHCb experiment being carried out at the Large Hadron Collider (CERN), the uand b-quark coupling strength characterized by the element Vub of the Cabibbo± Kobayashi±Maskawa (CKM) matrix has been measured for the first time by studying the baryonic decay. jVubj has been measured earlier in B-meson decay reactions only, with the exclusive and inclusive determinations showing a discrepancy at the level of 3s. In the LHCb experiment, the L0b-baryon decay probability was measured and jVubj was determined, the L0b ! pmÿ nm decay channel being examined for the first time. Thee jVubj value agrees well with the results of previous exclusive measurements in B-meson decays, but does not confirm inclusivemeasurements at the level of 3:5s. Although the Standard Model does not predict the value of the CKM matrix elements, it requires consistency in different processes. For this reason, to explain the discrepancy between jVubj measurements, several effects beyond the Standard Model were involved, for instance, the supersymmetry theory. To reveal or restrict the possible contribution from new effects, inclusive measurements should be additionally verified. Source:Nature Physics, online publication of July 27, 2015 http://dx.doi.org/10.1038/nphys3415


This paper presents the results of the conceptual design of passive safety systems for reactor power 225 MWth using Pb-Bi coolant. Main purpose of this research is to design of heat removal system from the reactor wall. The heat from the reactor wall is removed by RVACS system using the natural circulation from the atmosphere around the reactor at steady state. The calculation is performed numerically using Newton-Raphson method. The analysis involves the heat transfer systems in a radiation, conduction and natural convection. Heat transfer calculations is performed on the elements of the reactor vessel, outer wall of guard vessel and the separator plate. The simulation results conclude that the conceptual design is able to remove heat 1.33% to 4.67% from the thermal reactor power. It's can be hypothesized if the reactor had an accident, the system can still overcome the heat due to decay.


The development of disruptive technologies in the Marine field is an important means to seize the commanding heights of international scientific and technological competition and requires policy support from the government. Based on the concept of strategic niche management, this study quantitatively studied the construction and evolution of policy protection space during the development of China's deep-sea carrier equipment technology from 2001 to 2018. The research shows that :(1) from 2001 to 2018, three different types of policy tools were used in relevant technology policies, with the proportion of "expect establishment" 62.50%, "network construction" 6.58% and "learning and experiment" 30.92%, but the use of policy tools was not balanced. (2) on the whole, the growth trend of the number of deep-sea submersible development is lower than the trend of the use of policy tools, indicating that the use of policy tools has a certain impact on the development of deep-sea vehicle technology, but the effect is limited. From 2010 to 2018, the number of deep-sea vehicles developed and the number of policy tools used increased by three times and four times respectively compared with that from 2001 to 2009, indicating that the use of policy tools after 2010 has a significant role in promoting the development of deep-sea vehicle technology and industry. (3) China's deep-sea delivery equipment industry is still in the stage of technological niche, and the use of protective policy tools such as network construction should be strengthened.


The current study investigates the extent to which receptive vocabulary size test scores can predict second language (L2) speaking ability. Forty-six international students with an advanced level of L2 proficiency completed a receptive vocabulary task (Yes/No test; Meara & Miralpeix, 2017) and a spontaneous speaking task (oral picture narrative). Elicited speech samples were submitted to expert rating based on speakers' vocabulary features as well as lexical sophistication measures. Results indicate that vocabulary size was significantly associated with vocabulary rating. However, learners with large vocabulary sizes did not necessarily produce lexically sophisticated L2 words during speech. A closer examination of the data reveals complexities regarding the relationship between vocabulary knowledge and speaking. Based on these findings, we explore implications for L2 vocabulary assessment in classroom teaching contexts and provide important suggestions for future research on the vocabulary-and-speaking link.


In vitro propagation of Grand Naine banana (Musa sp. 'AAA') is gaining importance in the banana industry. However, the occurrence of somaclonal variants is at present limiting the use of tissue cultures plants in spite of several advantages. Hence a brief study was carried to characterize the somaclonal variants of tissue-cultured Grand Naine from the farmers' fields around Bangalore, India. Eleven positive variants were characterised based on their morphological and yield characters. To confirm the variants at the DNA level, Random Amplified Polymorphic DNA (RAPD) analysis was conducted to identify differences in the banding patterns. Forty three primers were used for the analysis of which OPF-09 differentiated the variants and the normal Grand Naine bananas. A band size of 320 bp was produced in all the normal samples but was absent in the variants tested. In the present study RAPD markers proved to effectively and precisely confirm the variants identified using molecular characters. Of the eleven superior variants analysed, variants GNV-04, GNV-08 and GNV-10 showed positive phenotypic characters which could be used in developmental programmes of Grand Naine banana.


The inherent librational characteristie of Helical-Gear has great influence to geared-motor and its correlative parts.Based on ANSYS,the paper makes a modal analysis of Helical-Gear,and calculates its low-order inherent livarational fxequency,the host librational model and maximum deformation and libration stress of each ordr with the analysis of livration mode nephogram,the paper provides rational evidence for the structual optimization design and the dynamic response of the Helical-Gear in Geard-Motor


Ceramic matrix composites (CMCs) are actively developed to replace metal alloys currently used in the hot parts of civil aircraft engines. This should improve engine efficiency and reduce environmental impact. The objective of the present study is to identify the weaknesses of the material under service. For this purpose, in situ tensile tests under synchrotron radiation are carried out at room temperature and at 1250°C. The damage mechanisms of the material under loading are identified. Digital volume correlation is used for analyzing cracks, in particular by studying discontinuities within the displacements fields. Finite element models are constructed directly from the tomographic images at the mesoscopic scale to reproduce numerically the experiments. Our results reveal a strong correlation between the weaving of the material and cracks initiation. It appears that transverse yarns planes act as stress concentrators and are the preferred places for crack initiation, which is consistent with the calculated stress fields. Mots Clés : Essais in-situ, Tomographie, Corrélation d'image volumique, Éléments finis, Composites SiC/SiC


The present invention relates to a method of culturing a cell by the cell culture method of the continuous perfusion culture comprising a cell culture medium and on the cell, wherein the addition of cell medium to the cell culture medium and outflow of liquid having a lower cell density than the cell culture the flow inside the hollow fiber to circulate the cell culture medium over a filter module comprising a (hollow fiber), the filter module is an alternating tangential flow that causes. Preferably, the addition of culture medium, in particular a spray rate and / or removing the biomass from the culture medium one or more times. The method is particularly suitable for the culture of the aggregated cells. In addition, the present invention relates to the production of antibodies by the biological material, preferably a cell, and wherein the biological material can be further purified by downstream processing.


The Cabibbo–Kobayashi–Maskawa (CKM) parameters are investigated in detail in recent predictive models which are based on low-energy non-Abelian discrete family symmetries. Some of the models can already be excluded at the present precision of the determination of the CKM parameters, while some of them seem to survive. We find that to make the uncertainties of the theoretical values comparable with the assumed uncertainties of ~1° and ~2° in ϕ2(α) and ϕ3(γ), respectively, at about 50 inverse atto barn achieved at a future B factory, it is necessary to reduce the uncertainties in the quark masses, especially that of the strange quark mass by more than 60%.


Free fatty acid release from fat cells, obtained from epididymal adipose tissue of rats of different sizes, was found to be dependent on the cell surface area, regardless of the age of the animals. The same result was found with cells of different sizes from the same animal. These results, when related to in vivo conditions, would indicate that for the same adipose tissue mass, activity would decrease with increasing cell size. On the other hand, the total activity of a given tissue would increase by increasing the size of its cells.


Two Fraenkel-Mostowski models are constructed in which the Boolean Prime Ideal Theorem is true. In both models, AC for countable sets is true, but AC for sets of cardinality 2 and the 2m = m principle are both false. The Principle of Dependent Choices is true in the first model, but false in the second.

Mathematics Subject Classification: 03E25, 03E35, 04A25.


Total cross-section measurements have been made of the /sup 26/Mg( p, n)/sup 26/Al reaction, with separate measurements of the cross sections to the first two excited states of /sup 26/Al from threshold to E/sub cm/ = 5.6 MeV. Thermally averaged reaction rates are tabulated over the temperature range 0.1< or =T/sub 9/< or =10 for the inverse reactions, /sup 26/Al(n, p)/sup 26/Mg, with the three lowest states of /sup 26/Al as ''targets,'' and compared to rates calculated on a statistical model.


The envelope theorem, now the fundamental tool in modem duality analysis, had its beginnings in Jacob Viner's classic 1931 article on shortand long-run cost curves. It seemed wrong to Viner that at any given point along the long-run cost curve, the long-run average cost curve should have the same slope as the short-run curve, where capital was being held constant. This is still a puzzle to many people, along with the various other envelope theorem results (see, for example, the discussion of a related issue by Sexton, Graves, and Lee 1993). Viner instructed his draftsman, Wong, to draw the long-run curve through the minimum points of the short-run average cost curves. Curiously, Samuelson's resolution of the puzzle in Foundations (1947) dealt only with a simple unconstrained maximum problem, maximize y = f(xl2 ... .. n, a), where the xi's are the decision variables and a is a vector of parameters. Its relation to the original Viner-Wong diagram seems a bit remote at first, and, curiously, a discussion of the envelope theorem in the explicit Viner-Wong context seems missing from the literature.' This is unfortunate because it is possible to communicate the essence of this result (and more general results) with a simple cost diagram that goes back to the roots of cost theory.


The purpose of this research was to analyze economic growth and shifting of economic structure of the origin district in Bengkulu Province. Base on BPS secondary time series data (2001-2017), descriftive analysis was used to analyze economic growth and shifting economic structure, specialty after the region otonomous era (OTDA).  The DLQ and SSA method was used to determine the potential and leading sectors to increase economic performance. The result of this research was conclude that expansion of the the region in Bengkulu Provinsi has positif impact on economic development for the origin district. The economis structure was shifting from premier sector to secondary and tertier sector. The potential and leading sector after OTDA become more than before (from 4 or 5 sector to 7 untul 9 sector). Keywords : Dynamic Location Quotient 1 , Shift Share Analysis 2 , Economic Growth 3 , Economic Structure 4 , Potential and Leading Sector 5


The coaxial probe technique is used to acquire the dielectric properties of biological tissues in the microwave frequency range. To dielectrically characterize heterogeneous samples, the sensing radius of the probe must be known. Thus, in this article, for the first time, both experimental and numerical investigations were conducted to analyze and model the sensing radius dependence on the probe dimensions. The results suggest that 1) the sensing radius increases linearly with the inner radius of the outer conductor and is not affected by the width of the outer conductor; 2) the inner conductor has higher impact than the insulator on the sensing radius; and 3) although the sensing radius depends on the dielectric properties of the investigated samples, the trend of the sensing radius relative to the probe dimensions is the same across different samples. Furthermore, a method for predicting the sensing radius, through use of neural networks, is proposed.


Photographic postcard. Black and white. Portrait of Simon and Francis (Hoffart) Bosch. Studio image of a man and a woman. Man is seated in a chair at the left. Woman stands on the right and has her hand on the man's shoulder. Couple identified as Simon and Francis (Hoffart) Bosch. Inscribed on the front: "Simon & Francis." Courtesy of Walter & Elizabeth (Bosch) Miltenberger Collection, 2009.07, GRHC.


In this study, we used a chip-on-chip test vehicle with 30μm pitch lead-free solder micro bump to study the electromigration reliability of solder micro bump interconnection used for 3D chip stacking. The structure of micro bump composed of Sn2.5Ag solder material with Cu/Ni under bump metallization (UBM) was selected. Two types of interconnection were chosen to evaluate the effect of the joint structure on electromigration behavior. The type I was the chip stacking sample with the IMC / Sn (5 um thick) / IMC joint structure, while the type II was the sample with fully transformed Ni3Sn4 intermetallic (IMC) joints made by the post-treatment of long time thermal aging. Electromigration test was performed on the four point Kelvin structure and daisy-chain structure under the current stressing of 104∼105 A/cm2 at an ambient temperature of 150°C. During the electromigration test, the resistance increase was in-situ monitored to determine the definite time to failure. The microstructure evolution was also examined at different stages of joint resistance increase. From the testing results, the rapid increase of joint resistance was found at the early stage under current stressing in the type I micro bump. After that, the joint resistance increase became slower. This mild increasing stage was much longer than the early stage. For the type II sample, however, the resistance increasing rate was quiet lower than that of the type I sample at the identical testing time. With a higher current density in the order of 105 A/cm2 in the micro joint, the effect of joule heating caused the damage happened in Al trace and Cu UBM while the residual Sn solder had been transformed to be Ni3Sn4 IMC totally and few voids were found around IMC by the microstructure observation. When applied a current density in the order of 104 A/cm2 on the micro joint, the residual Sn was also fully transformed to be IMC. However, the failure mode of the micro joint is not clear yet because the experiments are still on-going. The resistance variation is showing a steady state under such a condition of current stressing and so far no open failure happened.


This paper presents a lab based approach to teaching the undergraduate CS Information Security course. Given the magnitude of real and potential loses associated with security breaches, employers increasingly expect graduates of CS programs to have an understanding of information security concepts. The infrastructure requirements for the course includes setting up a secure laboratory environment to accommodate the development of viruses and worms. The labs and lectures are intended to instruct students in the inspection and protection of information assets, and detection of and reaction to threats to information assets.


Total hip replacement is rapidly growing procedure because of  pain relief ,restoring range of motion  and patient's satisfaction. Primary go is to restore individual geometry of patient's hip joint, long term components survival and most important- improving patient's quality of life. In past decades this surgery has several limitations as patient's age, bone morphology ( incl. anatomical deformities) ,previous surgeries ,etc.  Recently , with the development of modern implants ( cups and stems) these limitations are past.  Young patients indicated for THA are always great challenge , because their functional requirements , life expectancy ,anatomical variations (  due to congenital or acquired disorders) , greater mobility and higher risk of aseptic loosening. Standart  cementless  stems have some unsolved issues as fixed  intra / extramedular  dimentions, proximal stress shielding, impingement, etc. They are based on 2D-planning and often have mismatch between acetabular and femoral center of rotation. Custom femoral  stems are based on specific 3D- scan of the hip joint, which presents  individual  shape of  acetabulum and especially femoral canal. This allows  optimal bone support for the stem, preserving bone substance , excellent  contact bone-stem and most important- restores center of rotation. For the period 2010-2014  we  operated  16 patients , 8 were  with Osteoarthrosis (OA); 4-with Avascular necrosis (AVN) ; 2 with dysplastic hips (DDH) and two with posttraumatic osteoarthrosis . Follow up is 6-42 months. We perform THA with modified  posterior surgical approach with minimal femoral reaming, due to individual femoral rasp with the same size  as the customized  femoral stem.  During  the follow up period we found no complications,Harris Hip Score was 97 pts.  and  85%  of  the patients had regular physical exercises for 3 weeks.


Decomposition methods play a critical role in cooperative co-evolutionary algorithms (CCEAs) for solving large-scale optimization problems. Although some well-performing decomposition methods have been designed based on the interactions among variables (IaV), their grouping accuracy is still limited due to the poor performance on the overlapping problems and the computational roundoff errors of IaV in the implementation. To deal with these limitations, a graph-based deep decomposition (GDD) method is proposed to obtain more accurate grouping results, especially for the overlapping problems. On the one hand, the GDD mines the IaV information and obtains the minimum vertex separator of the interaction graph of variables, so as to group variables deeply and recursively. On the other hand, the GDD has the ability of fault tolerance to deal with the computational roundoff errors of IaV and can improve the grouping accuracy. For better experimental studies of overlapping problems, a novel overlapping function generator is designed with the random and complicate overlap type, and two new metrics are proposed to evaluate the grouping accuracy. Comprehensive experiments show that GDD can greatly improve the grouping accuracy and help CCEAs perform better than other existing algorithms, especially on the overlapping problems. In addition, the GDD is highly fault tolerant and can divide problems accurately even on the inaccurate IaV.


The molecule of the title compound, C7H7N5O2S2, is non-planar. The dihedral angles formed by the thiohydantoin and methylthiadiazole systems with the amide group are 85.5 (1) and 38.4 (3)°, respectively. The crystal structure is stabilized by intermolecular N—H⋯N/O hydrogen bonds and short S⋯O contacts, forming a three-dimensional network.


Let s, r ∈ ℕ and be the quantized walled Brauer algebra. The quantized walled Brauer algebra admits two distinct one-dimensional representations. These are generated by central elements of called the symmetrizer and the anti-symmetrizer of . We compute explicitly the coefficients of these two elements with respect to a diagrammatic basis of .


From the perspective of theories of public policies and sports sociology,and by using statistics in the survey of the current state of "Public Participation in Asian Games 2010 in Guangzhou",which indicated that the public have a relatively high degree of understanding,participation intention and expectation of stadium related de-cisions,but have a relatively low degree of right awareness and participation with actual actions,the author ana-lyzed and demonstrated that "democratized decision making" is the inevitable way to the development of stadiums in China,and probed into the course of action to democratized decision making in such 5 aspects as establishing a rational need investigation procedure,establishing and perfecting the system of stadium decision voting by democ-ratic groups and the public,perfecting the stadium construction budget monitoring mechanism,becoming a public product supply responsible government,and democratization of stadium financial decision making.


A reconnaissance study suggests that on alpine slopes in the Colorado Front Range which have both a soil and winter snowcover, pocket gophers (Thomomys talpoides) may be the dominant geomorphic age...


From August 2004 to October 2005 we underwent 13 procedures using SGAP(superior gluteal artery perforator)as pedicles by either advancement(8/13)or interpolated(5/13)flaps in reconstruction of twelve sacral ulcers in twelve patients. Three(two interpolated and one advanced flaps)of the thirteen procedures were complicated with venous congestion and hematoma, two were saved by decompression with tunnel widening and flap debulking, however the other one interpolated flap was lost post salvage and the defect needed resurfacing by a V-Y advancement SGAP flap from the opposite side. Ten of the thirteen flaps survived completely without morbidity and only one recurrence noted after an average 10 months follow-up. We found the interpolative moving of flaps and the thickness discrepancy between defects and flaps (the SGAP flaps were usually too bulky for shallow sacral ulcers)may increase the risk for torsion of pedicle and venous congestion that resulted in serious complication even flap loss.


The Grid-connection of large-scale intermittent generations brings new challenges to transmission networks (TN). Based on the analysis of life cycle cost (LCC) of TN, taking TN planning as the main decision issue and reliability assessment as a sub-issue, a master-slave relationship of hierarchical decision is formed. Using the multilayer programming theory, a bi-level programming model of TN is proposed. The upper level aims at the optimal LCC and generates a planning scheme. Considering the uncertainties of intermittent generation outputs, loads and line outages, a linear dc stochastic optimal power flow model (SOPF) is formulated to assess the reliability of the generated scheme on lower level. Hybrid algorithm combined an improved deferential evolution algorithm, three-point estimate method and linear programming is adopted to solve the proposed model. Results of 18-bus system show feasibility and validity of proposed method.


"This publication has presented an overview of current research on MPC joints in wood trusses. The literature search was primarily of U.S. sources, with some effort to obtain literature from other parts of the world. An
enormous amount of important information has been amassed by studies on testing procedures and theoretical models. Among the many attributes that must be considered in modeling and analysis of joints and trusses are the effect of load angle, wood-plate orientation, size, thickness, stiffness
of steel plates, and specific gravity of wood on the strength of the joints, as well as the effect of the gap closure between members, tooth damage or length, and tooth layout on the overall joint performance. Extensive research has been done on tension joints in trusses; some has been done on heel connections, but very little has been done on web and other connections. Researchers have devoted considerable effort to
understanding tensile joints under axial loading. However, experience suggests
that even tensile joints are subjected to combined loadings because of eccentricities.
The behavior of a simple MPC joint is very complex and influenced by many variables, including plate properties, joint geometry, and the natural variability of wood. An integrated approach, as used by Foschi (1977), that considers the material behavior and interactions of wood and plate and that is simple but sufficiently accurate for designing joints should be developed. A standard method for studying the long-term behavior of MPC joints should be developed and used in design. One possible option
would be to use a time-temperature superposition principle for developing
long-term data from relatively short-term tests. Failure modes of the truss
joints should be characterized. Work on dynamic behavior and environmental
effects on the joints is also needed."--Summary and conclusions.


Of all medieval Jewish philosophers after Maimonides, the one whose legal thinking is most constitutional was Rabbi Nissim ben Reuben of Girona, known by the acronym Ran (Rabbenu Nissim). He was born in about 1310 and died in 1376. He lived, taught, and judged in Barcelona, then part of the Crown of Aragon. A prolific writer, he authored a celebrated commentary on Rabbi Isaac Alfasi's Sefer ha-Halakhot and a commentary on the tractate of Nedarim, printed in standard editions of the Babylonian Talmud and customarily studied in the place of Rashi's commentary (which does not exist on that tractate). In addition, he wrote novellae on selected tractates of the Babylonian Talmud and scores of legal responsa. In the realm of philosophical thought, he composed an influential collection of philosophic homilies, known as Derashot ha-Ran ("The Homilies of Rabbi Nissim"); and he also wrote an unfinished commentary on the Pentateuch, ending with Gen 23:20. All of his works were written in Hebrew.1 Ran was the leading authority of his day in rabbinic law and the most original Jewish political philosopher between Maimonides and Abrabanel. He was also, as already said, the most constitutionally minded of all medieval Jewish philosophers after Maimonides. It is because of the constitutional nature of his legal philosophy that I have entitled this paper, "Rabbi Nissim of


The risk to develop breast cancer varies at least five fold around the sor1d, Migrant women from low incidence countnes to the United States c\pcricnce a radual merease n risU suggesting that it takes more than one generation for migrants to adopt the risk f the host country and that risk ftc tors may act earlx in life or in ulero. in Hawaii first generation migrant rates were already more than twice as high a rates in Japan 36 \ s. I 3 cae per 100,00(11 and increased to 57 cases per 11(0. t)0( ( for the second eneration. \ hi Ic brcust cancer incidence in Japan a cragcd approximately 28.6 per I 00,000 women during 198$ to 19922. women with Japanese ancestry in the United States eerienced incidence rates of $2.3 per I 00.000 ssornen as compared to IllS per lOt.t.000 Caucasian women: Ethnic dtft'erences can he partially explained by mnenstrtmal. repro ductive, and anthropometric factors, but a large proportion of the discrepancy in risk remains unexplained.A comparison between breast cancer risk factors in China and in the United Statcs found that the combined ponulation attributable roT was 63ffor repro— ductive factors and anthropometric factors. leaving a large propor tion of risk unexplained. Thirty years ago, it was proposed 5 that cthntc dilfetcnccs WCtc a n ttlt of sn ttonmen( 0 and hi 5. st\ Is. factors whtch are mortified only with the passtng of generattons. According to this hypothests. breast cancer risk among descendants of migrants will he similartothe risk of thehostpopulation once they have achieved full acculturation. One of the more apparent changes that migrants. itt particulir Asian migrants. experience over time are eannc' patterns. Because ot the large number or Japanese migrants a ho came to Hawaii dttring the beginning of the 20 centur and thanks to the Hawaii Tumor Registry established in 1960, Hawaii has been an ideal place to study the effocts of nutrition on breast cancer ittcmdertce and tiiortauitv. Early dietars research itt i-lassaii showed that comiipamcst to Jipi nese migrants, second generation Japanese consumed less Asian foods, such as rice, tofu, sashimi, salted fish, green tea and more Western foods. uch a meat and en Ifile. In terms of nutrments, fit intake a as higher in the second generation, while protein intake renaincd equal Fat and ptctei 1 intake was correlated ss oh breast cat.icer in an aggregate study de.sig.n 5,hut i.n a case-control study 7 n.o strong support for the fat hypothesis was detected. A later study 5 described an increased risk of similar mnagititude among Caucasian and Japanese ostmenopausil wotmien wmth the eonstitmsption of sausage. m eats, and dairy items, bitt no stunt ficant association for fat, saturated fat. cr ar.imai protein. As a re.su.it of the e.arly di.etary fat studies around the ssorld, the \V1NS (Women's Intervention amid utrition Studs was iniriatcsf Cancer ssmrs mvor. I 54 a milieu in Hmsvaii out of 2.400 nationwide, has e been randomnizesm to I 101k tat vs. regular diet to cletermi.ne whether dietary fat re.duction Os post-menopausal wom.en with breast cancer will decrea.se th rern 10.57 mate inst pi'olon: dfcase—trec urviva1. Over time. a large nutritional data base has been developed at the Cancer Research Center. It contains a food composition table with information on I 32 nutrients and food components for 2200 foods, man' of theni based on recipes used by different ethnic groups in Hawaii. In a large mulitethnme cohort of diet anti cancer established in 1995 1 more than 200,000 men and women in Hawaii and Los Angeles have completed a quantitative scannable food frequency sluestioitnaire a hich a as anal zed with the help of the ntitrmtmonai data base. This cohort5tudy will follow more than 50.000 woitmen of Caucasian, Japanese. and Native Hawaiian ancestry tim Hawaii for many years. Data from the questionnaire will provide the opportu— rmitv to analyze the effect of different foods and nutrients on ht'east cancer risk. In addttioti. blood and urine samples ss ill be collected ama) anals zed tom vilanitns. minerals, and phvtoestrouens to deter mine possible associations with breast cancer risk, In recent years, accumulated dietai'y research from many different populations has questioned the role of dietar fat in bm'east cancer ctiolog and lead to a shift mu rescam'ch focus ti.) other aspects of nutrition, in particular. t'rumts and egetables as a eli as soy foods I have been investigated as potentially protecting against the disease, a hereas excess ' alone intake and adult weight and gain in body ittass • tie sLispeeted to inci'ease breast cancer risk through a medi ating effect of tnsttlin md related growth factors.: Sos foods and sot1avones, phytoestrogens c' untamed in soy products. have beet) a research focus at the Cancer Research Center for many years, The Anals tie il Lahoratori at the Cemmier has the ability to measum'e isoliavone levels in a arietv of foods and in hod fluids° and has shown that urinary isoflavone exeretmon can be used as a marker of soy intake, 0'A case-control study which included Asian-American a omen from HawaiU' detected a 30U' decreased risk of breast cancer for women hormt who i'epot'Ied eating tofu moi'e than once a week as compared to womemi who ate tofu less than once a month. However, the protectis e effect of soy was primarily obsersed among women horn itt Asia . After completing a pilot clinical trial with isofias one tablets, the BEAN (Breast. Estrogens .And Nutrition) studs. now investigates the h pothesms whether two servings of soy l da as tofu, soy tnilk. so\ nuts. protein isolate, or so\ hart will alter menstrual cc' Ic length and circulating estrogen levels, which lire considered predictors of breast cancer risk, 5 in premenopausal \s onten dmmrmng a two-s ear ittterventmon. In cooperation a ith several mtmammographmc Jimmies. appt'oxitnatel 2( (ft wonien has e been re cruited into this stud so far. Comparison of rnamtnograms at baseline and at the end of the study will provide us with information a hether soy foods affect the appearance of healthy ntamtuograms as suggested in a prevm ams 5tttd2l . Mamntouraphic density t tn i mtdepemident rfrk factor for breast cancer conferring an approxi ntatel fourfold risk to develop the diseasOs' in women a ith a large pi'Oportion of dense areas in their mammograms when c tnpareil to women a mth mIte lowest dettsmtv pattem'ns. As part t the mttlttc.thnic Tort. a mantnioeraphic density research proieet ss ill explore possible influemices of. soy fom ds and other dietary factors on mint mographic densities. An emtierging area of pm'ommsittu research is the interactiomt between mmtritmonal intake and polvnmorphisms in genes coslitig for enzstmtes thai ats'in\ mOved in the chemical activation and detoxification of mtutrieitts, carcinogens, and hornsones. The interaction hypothesis may he able to explaimm why persons with the sanic geitetic material


Broadcast postemerge application of urea-ammonium nitrate solution (28 and 32 percent UAN) to corn has the potential to cause phytotoxic symptoms of leaf burn, necrosis, loss of leaves, and plant stunting. Burn symptoms will be visible within 24 to 48 hours after application. With hot-dry conditions, appearance of darkened leaf tissue can begin within a few hours. Depending upon the severity of damage, reduced plant growth may be visible for several weeks after application.


The method of synthesis of frequency dividers of harmonic oscillation on nonlinear jet elements is proposed. Its essence consists of searching a mode with the maximum output power and/or the maximum power transfer factor and circuit design of the founded optimum mode. The method is illus t rated on the concrete example.


Purpose: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor, often metastatic at presentation, for which current chemotherapeutic regimens are largely ineffective. As its pathogenesis is still unknown, we hypothesized that deregulation of signaling pathways commonly activated in cancer may contribute to MCC tumorigenesis and may provide insights into targeted therapy approaches for this malignancy. Experimental Design: We retrospectively profiled 60 primary MCC samples using a SNaPshot-based tumor genotyping assay to screen for common mutations in 13 cancer genes. Results:We identifiedmutations in9 (15%)MCCprimary tumors, includingmutations inTP53 (3of 60) and activating mutations in the PIK3CA gene (6 of 60). Sanger sequencing of the primary MCC tumors detected one additional PIK3CAmutation (R19K) that had not been previously described in cancer. Merkel cell polyoma virus (MCPyV)was detected in 38 (66%)MCCcases andpatientswithMCPyV-positive cancers showed a trend toward better survival.With one exception, the presence ofMCPyV and activatingmutations in PIK3CA appeared mutually exclusive. We observed that signaling through the PI3K/pAKT pathway was active in one MCPyV-positive and in all MCPyV-negative MCC cell lines, as evidenced by AKT phosphorylation. Importantly, the presence of a PIK3CA-activating mutation was associated with sensitivity to treatment with ZST474, a specific phosphoinositide 3-kinase (PI3K) inhibitor, and to NVP-BEZ235, a dual PI3K/mTOR inhibitor, targeted agents under active clinical development. Conclusions: PI3K pathway activation may drive tumorigenesis in a subset of MCC and screening these tumors for PIK3CA mutations could help identify patients who may respond to treatment with PI3K pathway inhibitors. Clin Cancer Res; 18(5); 1227–36. 2012 AACR.


A current sheet susceptible to the tearing instability is used to drive reconnection turbulence in the presence of a strong guide field. Through nonlinear gyrokinetic simulations, the dependencies of central quantities such as the heating rate on parameters like collisionality or plasma β are studied, revealing that linear physics tends to predict only some aspects of the quasi-saturated state, with the nonlinear cascade responsible for additional features. For the solar corona, it is demonstrated that the kinetic heating associated with this type of turbulence agrees quantitatively with observational volumetric heating rates. In the context of short particle acceleration events, the self-consistent emergence of plasmoids or flux ropes in the turbulent bath is found to be important: ubiquitously occurring merger events of these objects cause strong bursts in the heating rate, the timescale of which is consistent with nanoflare observations. Furthermore, anisotropy of the temperature fluctuations is seen to emerge, hinting at a new means of generating coronal ion temperature anisotropy in the absence of cyclotron resonances.


In this paper we give out a sufficient and solution of quadratic function's maximum with theory of quadratic form and give out the definition of the positive definite property of the following homogeneous polynomials of degree In two variables function, based on the definite of local maximum of two variables function.


The present application relates to a laser marking device configured to perform permanent prints onto an ophthalmic lens, which is made of at least one predetermined material. The device is in particular configured for emitting a focused beam of UV laser radiation pulse having at least one radiation wavelength between 200 nm and 300 nm, a pulse duration of between about 0.1 and about 5 ns ns and a pulse energy of between about 5 μJ to about 100 μJ. The present application further relates to a laser marking method configured to provide permanent prints on an ophthalmic lens using the above device.


Chronic fatigue syndrome (CFS) is an increasingly common chronic medical condition that affects not only patients but also their families. Because family dynamics, particularly the family life cycle, can and does influence the disease process, those providing counseling to CFS patients and their families would do well to recognize these dynamics. CFS as a disease process is experienced differently throughout the family cycle. This process is described and illustrated with case material.


The International Journal for Quality in Health Care, which is an official journal of the International Society for Quality in Health Care (ISQua), presents two editor's choices in this issue. Together they span from the unit through to the system levels, and capture the diversity, challenges and positive benefits associated with healthcare continuous quality improvement studies.


The present invention, respectively a dentin restorative material kit comprising a combination of color tones of different kinds of curable paste, the curable paste is cured body having a thickness of 3.0mm obtained by curing these the when colorimetry black background conditions, in the value of the range of lightness L


Submitted for the DFD09 Meeting of The American Physical Society Droplet formation from the breakup of micron-sized liquid jets WIM VAN HOEVE, ARJAN VAN DER BOS, MICHEL VERSLUIS, JACCO SNOEIJER, Physics of Fluids, University of Twente, The Netherlands, MICHAEL P. BRENNER, School of Engineering and Applied Sciences, Harvard University, Cambridge, USA, DETLEF LOHSE, Physics of Fluids, University of Twente, The Netherlands, PHYSICS OF FLUIDS, UNIVERSITY OF TWENTE, THE NETHERLANDS TEAM, SCHOOL OF ENGINEERING AND APPLIED SCIENCES, HARVARD UNIVERSITY, CAMBRIDGE, USA TEAM — Droplet formation from the breakup of a liquid jet emerging from a micron-sized circular nozzle is investigated with ultra high-speed imaging at 1 million frames per second and within a lubrication approximation model [Eggers and Dupont, Phys. Rev. Lett. 262, 1994, 205-221]. The capillary time τc = √ ρr3/γ is extremely small – of the order of 1μs. In the analyzed low Reynolds number regime the jet breakup is driven by surface tension forces only. Rayleigh breakup is not influenced by the surrounding air. The highspeed imaging results and those from the model calculation perfectly agree for various liquid viscosities and jet velocities, confirming a universal scaling law also for diminutive Rayleigh jets. Wim van Hoeve Physics of Fluids, University of Twente, The Netherlands Date submitted: 04 Aug 2009 Electronic form version 1.4


The polarized gluon distribution function Δg(x) is presently studied at various deep inelastic scattering and pp experiments. The goal is to eventually determine the contribution of the gluon spin ΔG to the overall spin‐1/2 of the proton, given that the quark spins are known to only contribute at the level of 30%. A review of the present status and prospects will be given.


Diagnosing liver nonalcoholic steatohepatitis (NASH) using non invasive procedures is challenging because the visual aspects in US imaging between healthy and affected liver are very much alike. Attenuation and backscattering coefficients are employed to determine the behavior of the US beams into the liver tissue. The values of these coefficients generate features for a classifier. We try to determine if is possible to discriminate between healthy and steatohepatitis patients and if is possible to assess the steatohepatitis grade. Support vector machine is used as a classifier and the Cohen's kappa statistic evaluates the performance of the classifier. Experiments performed on US images acquired from a lot of 51 biopsied patients shown that these coefficients can successfully be used to distinguish between healthy and moderate/severe steatohepatitis. The role of fibrosis stage and fatty is also investigated. Brunt score is used to assess the steatohepatitis grades. Fibrosis stage and steatosis grade are also determined.