Two NIR emitting platinum [Pt(N^N^C)(phosphine)] and iridium [Ir(N^C)2(N^N)]+, complexes containing reactive succinimide groups were synthesized and characterized with spectroscopic methods (N^N^C - 1-phenyl-3-(pyridin-2-yl)benzo[4,5]imidazo[1,2-a]pyrazine, N^C - 6-(2-benzothienyl)phenanthridine, phosphine - 3-(diphenylphosphaneyl)propanoic acid N-hydroxysuccinimide ether, N^N - 4-Oxo-4-((1-(pyridin-2-yl)-1H-1,2,3-triazol-4-yl)methoxy)butanoic acid N-hydroxysuccinimide ether). Their photophysics was carefully studied and analyzed using TD DFT calculations. These complexes were used to prepare luminescent micro- and nanoparticles with the "core-shell" morphology, where the core consisted of biodegradable polymers of different hydrophobicity, namely, poly(D,L-lactic acid), poly(ε-caprolactone) and poly(ω-pentadecalactone), whereas the shell was formed by covalent conjugation with poly(L-lysine) covalently labeled with the platinum and iridium emitters. The surface of the species was further modified with heparin to inverse their charge from positive to negative value. The MPs size determined with DLS varies considerably from 720 to 1480 nm, but NPs diameter falls in a rather narrow range, 210-230 nm. The species with poly(L-lysine) shell display high positive (> 30 mV) zeta-potential that make them essentially stable in aqueous media. Inversion of the surface charge to negative value with the heparin cover did not deteriorate the species stability. The iridium and platinum containing particles display emission, the spectral patterns of which were essentially similar to those of unconjugated complexes that indicate retaining of the chromophore nature upon binding to the polymer and further immobilization onto polyester micro- and nanoparticles for drug delivery. The obtained particles were tested towards their ability to penetrate into different cells types: cancer cells, stem cells and fibroblasts. It was found that all types of particles could effectively penetrate into all cells types under investigation. Nanoparticles were shown to penetrate into the cells more effectively than microparticles. However, positively charged nanoparticles covered with poly(L-lysine) seem to interact with negatively charged proteins in the medium and enter the inner part of the cells less effectively, than nanoparticles covered with poly-(L-lysine)/heparin. In the case of microparticles, the species with positive zeta-potential were more readily up-taken by the cells than those with negative one.


"New Engineering" corresponds to emerging industries that first refers to specialties for emerging industries such as artificial intelligence, intelligent manufacturing, robotics, cloud computing, etc., and also includes the upgrading of traditional engineering majors. Through the understanding of the new engineering education and the development of science and technology, this paper studies and designs the teaching space for the new engineering specialties and upgrading engineering ones. Based on the analysis of the case of teaching space reconstruction of the Human Settlements College of Xi'an Eurasia University, we can draw some conclusions: the first is to summarize the method of teaching space planning and design of new engineering subjects; The second is how to create a teaching space that stimulates innovation ability and normalizes learning behavior; The third is to promote a new student-centered education model. We hope it will be able to provide certain reference value for teaching space planning designers of both new engineering and engineering majors.


This present study is aimed to find out the correlation between Javanese cultural values orientation, personality trait, and forgiveness among Javanese college students. We propose several hypothesis: (a) there would be a positive and significant correlation between Javanese cultural values orientation and forgiveness, (b) there would be a positive and significant correlation between agreeableness, openness, conscientiousness, extraversion and forgiveness, (c) there would be a negative and significant correlation between neuroticism and forgiveness. A hundred students participated this study by filling out three questionnaires: forgiveness scale, cultural value orientation scale, and personality trait scale. Pearson correlation analysis shows that all hypothesis was accepted.


The electronic properties of the conjugated backbone of polythiophene can be tailored by the incorporation of alkyl and perfluoroalkyl substituents. A regioregular copolymer with alternating alkyl and perfluoroalkyl substituents displays absorption and emission maxima between those of the homopolymers composed of the individual structural units. However, the combination of the alternating electron-rich and electron-poor units, together with a small twisting influence of the perfluoroalkyl groups, provides a material which displays enhanced solution-phase fluorescence and strong solid-state fluorescence which is absent for the wholly alkyl analogue.


The use of glycerol residue, a palm oil waste from Oleochemical industries as a raw material for the production of succinic acid with immobilized cell fermentation process was investigated. In this work, the raw material, immobilized cells to produced succinic acid were characterized by Fourier Transform Infrared Spectrometry (FTIR) and Scanning Electron Microscope instruments. Based on the results, the functional group appearing for treated and commercial glycerol is the hydroxyl, aromatic methoxyl, alkenes, soap, carbonyl and alcohol group. The hydroxyl group which is O-H appeared at a spectra value of 3394.27 cm-1for the treated glycerol and 3299.96 cm-1 for the commercial group. Respectively. From the analysis of SEM for bead, it was found that majority of pores fall within range and the shapes was ellipsoid and a thick skin around strains was detectable, therefore indicating that immobilized cell prepared for fermnatation process is an attractive source for succinic acid applications


Nearly 60 years after the first description by Barlow, mitral valve prolapse (MVP) still remains a diagnosis of great interest and intense controversy. This continuing concern is driven by the high prevalence of this valvular disorder, detected in 1.2%–2.4% of the general population, and its not infrequent association with symptoms including atypical chest pain, exertional dyspnoea, palpitations and anxiety (MVP syndrome) and clinical findings including midsystolic click, low blood pressure, leaner build and ECG anomalies. It is also common in cardiovascular conditions including significant mitral regurgitation (MR), infective endocarditis, cerebrovascular ischaemic events, ventricular arrhythmias (VAs) and even sudden cardiac death (SCD). On the other hand, strong controversy arises from the general lack of knowledge of the pathophysiological basis underlying most of these associations, especially with VAs and SCD, which might be coincidental in such a common disorder like MVP.


We have developed Ludicrous Speed Linear Mixed Models, a version of FaST-LMM optimized for the cloud. The approach can perform a genome-wide association analysis on a dataset of one million SNPs across one million individuals at a cost of about 868 CPU days with an elapsed time on the order of two weeks. Significance Identifying SNP-phenotype correlations using GWAS is difficult because effect sizes are so small for common, complex diseases. To address this issue, institutions are creating extremely large cohorts with sample sizes on the order of one million. Unfortunately, such cohorts are likely to contain confounding factors such as population structure and family/cryptic relatedness. The linear mixed model (LMM) can often correct for such confounding factors, but is too slow to use even with algebraic speedups known as FaST-LMM. We present a cloud implementation of FaST-LMM, called Ludicrous Speed LMM, that can process one million samples and one million test SNPs in a reasonable amount of time and at a reasonable cost.


Abstract We have investigated the increased rate of glycolysis following transformation of chick embryo fibroblasts by Rous sarcoma virus. In both normal and transformed cells the regeneration of adenosine 5′-diphosphate and orthophosphate was found to be the rate-limiting factor for glycolysis. The plasma membrane Na + -K + -adenosine-5′-triphosphatase (ATPase) was a major contributor to adenosine 5′-diphosphate and orthophosphate regeneration in the fibroblasts, but its contribution was not changed by viral transformation. Neither protein synthesis, nor nucleic acid synthesis, nor microtubular function contributed significantly to the adenosine 5′-diphosphate and orthophosphate pools required for glycolysis either before or after transformation. Measurements of oxidative phosphorylation and of ATPase activity of isolated mitochondria did not reveal any changes following transformation that could account for the increased rate of glycolysis. We propose that an ATPase, which is not sensitive to conventional inhibitors of the Na + -K + -ATPase or mitochondrial ATPase, appears or is increased after transformation. Culturing chick embryo fibroblasts in the presence of artificial ATPase activators, such as dinitrophenol or gramicidin, mimicked some of the characteristic changes induced by viral transformation. The apparent K m of glycolysis for glucose was decreased by about 10-fold, and the apparent V max of hexose transport was increased by about 4-fold. In contrast to transformation, ATPase activators did not change the apparent V max of glycolysis or the activity of hexokinase, nor did they mimic the morphological and growth characteristics of transformed cells.


This document provides a guide to the selection of modified binders including multigrade bitumens for different treatments and service conditions, and to assist in the use and interpretation of the Austroads Specification Framework for Polymer Modified Binders and Multigrade Bitumens (AGPT/T190).


Background It is estimated that more than half of all women in adolescence age suffer from dysmenorrhea and it often interferes with their daily physical and emotional aspects. It is the leading cause of short-term school absenteeism and is associated with a negative impact on academic and daily activities. Objectives To investigate impacts of dysmenorrhea, factors associated with it, and its self-management strategies used by health science students. Methods A cross-sectional institution based study was conducted among 246 Mekelle University health science students selected by stratified random sampling technique. Data were collected using self-administered semistructured questionnaire. Data were analyzed using SPSS 16. Results The prevalence of dysmenorrhea was 71.8%. Participants who had long menstrual cycle interval, long menses flows, and positive family history and who were alcohol users were more likely to had dysmenorrhea. Participants reported that 28.6% feel depressed, 16.2% are absent from class, and 22.9% had poor personal relationship due to dysmenorrhea and 78.2% of them practiced self-medication. Conclusion Dysmenorrhea is common among Mekelle University health science students and it is major problem representing the cause of feeling depressed, poor personal relationship, and class absenteeism. Majority of the study participants used self-medication to treat dysmenorrhea.


In 1985 a number of biodynamic vegetable producers, who were involved in multiplication and breeding of open pollinated varieties, set up the "Initiativkreis für Gemüsesaatgut aus biologisch-dynamischen Anbau" (The Initiativecircle for vegetable seeds from biodynamic farming). Within this informal platform they exchanged experiences and discussed issues related to organic seed multiplication and breeding. During the years they realised that, to avoid conflicts between the time dedicated to professional vegetable production and time dedicated to breeding, the vegetable producers needed some economic compensation for their breeder activities. To promote their breeding work, raise funds and coordinate their breeding activities, members of the "Initiativkreis" established the (non-profit) association Kultursaat in 1994. At present eighteen breeders are working by order of Kultursaat. These breeders are located all over Germany, one breeder is situated in the Netherlands and two others are based in the north of Switzerland. Together they cover all major vegetable crops, such as e.g. carrot, cabbage, lettuce, tomato, sweet pepper, pumpkin, cucumber, onion, leek, beans and beetroot. The crop choice of each breeder depends on his individual interests and affinity with the crop. But Kultursaat also actively stimulates gardeners to pick up breeding of crops that are not included in its activities yet. The breeders are financed through Kultursaat for their breeding activities. To apply for funding, each breeder has to submit a project proposal once a year that is evaluated by the executive board, a committee that consists of five of the members, mainly breeders themselves. The association also handles the official procedures for the registration and application for breeders' rights of new varieties. When breeders' rights are granted, the individual breeders transfer these rights to the Kultursaat association. Another important field is the exchange of knowledge and experiences between breeders. This is realised by biannual meetings. Furthermore, new breeders are personally coached by more experienced members and the more experienced breeders also can ask for personal coaching by one of the other members. In 2007 Kultursaat also started a genebank for the collection and in situ maintenance of open pollinated varieties (co-funded project by the German Federal Program for organic farming). Besides practical breeding and seed multiplication, the members are also active in developing new plant evaluation and breeding methods that are inspired by anthroposophy, such as peripheral effects (e.g. biodynamic preparations, planetary configuration, sound) on appearance of plants and breeding and picture forming methods (e.g. copper chloride crystallization and rising pictures) to evaluate quality.


Conceicao Evaristo, a writer from the State of Minas Gerais, brings as her mark the literary production born out of the life experience of the black person in Brazilian society, which shakes hegemonic literary structures and patterns. It is discussed in this article the thematic of childhood in the work of Conceicao Evaristo, Poncia Vicencio , which can also be read as a breaking of standards by offering prominence to the child. As we will see, in this novel, the childhood of the characters transits historically between past and present, describing the different forms of learning, the games and frolics, fantasies, violence and oppression, in consonance with the identity inheritance of the characters, that, once adults, rethink the child's look and feelings. In a society that prioritizes the point of view of the experienced adult, the small black child acquires centrality and is able to narrate the own paths, from their social, racial status and also their gender. As will be seen, a social critique of the slave-making past permeates the whole book. The novel is constituted from a sinuous structure, since its reading depends on the memories of the main character, who enters in several labyrinths until finding an exit to its suffering and prostration before the situation of social and racial inequality experienced by her and by her family. In this sense, Evaristo presents us the possibility of thinking infancy in a plural way, for it invites us to think twice about the conception of what the children's universe is, beyond innocence, lost paradise, colorful toys, and standardizing school desks.


There has been some question about sexual allocation in outbreeding simultaneous hermaphrodites. In particular, under what circumstances should they invest equally in male and female functions? An attempt was made to determine the pattern of allocation of reproductive effort in the hermaphroditic teleost fish, Hypoplectrus nigricans (Serranidae), and to elucidate the factors influencing that pattern. Most of the gonad of H. nigricans is comprised of ovary, the testis forming only a thin band of tissue on the outside of the gonadal capsule. On a given day of spawning, eggs comprise most of the biomass of the gametes released. Courtship behaviors are at least as much female as male functions. Thus, most of the reproductive effort is spent on female functions. This pattern is not accounted for by inbreeding, low density, or partial parthenogenesis, but by the structure of the mating system. Hamlets "trade eggs," giving up eggs to be fertilized in exchange for the opportunity to fertilize those of another individual. Together, egg trading and the pattern of allocation of reproductive effort account for the evolutionary stability of the hermaphroditism by providing a fecundity advantage similar to that of parthenogens over sexual organisms.


Even though the interventions were adapted from standard clinical practice, the way they were provided meant that the care given infants in the study was distinctly different from standard care, with different risk profiles. Parents should have been informed about those differences.


The author puts forward that data for studying the pronunciation history of Jin Dialects includes contemporary dialect data and historical document data.The former involves the present data of all kinds for studying Jin Dialects and the data for studying the rest important dialects;The latter contains the rhyming dictionaries and poetry rhymes of Jin people in different periods,the notes of the pronunciation of Jin Dialects scattered in ancient books and records in different historical periods,and the accomplishment made by sorting out the data of the pronunciation of the external territory languages with the pronunciation of Northwest Dialects in Chinese language.At last,the author suggests we adhere to four principles for studying the the pronunciation history of Jin Dialects.


"this trial was just." (Though in somewhat of a different category, it might be well to compare The Case of General Yamashita by A. Frank Reel, University of Chicago Press, 1949.) Because of their intimate connection with the case, the authors have been able to anticipate and answer legalistic criticism pertaining to the "ex post facto" issue, the meaning of aggressive war, the crime of conspiracy in international law, and the inadequacy of the procedures under which the trials took place. If what happened at Tokyo (and Nuernberg as well) is really taken to heart by all nations, large and small, it will indeed go a long way to demonstrate the validity of the statement of the authors that "world society [has] vindicated the rule of law and order among nations" and insured itself with "a policy of prevention and deterrence." Though the Tokyo Trials took place between 1946 and 1948 (the original proclamation authorizing the trials was dated January 19, 1946, and it was not until December 23, 1948, that sentences were pronounced), there is a ring of currency about the book. In the first place, there is a side of General Douglas MacArthur (other than military and/or attempted policy-making) that is presented which has perhaps been lost sight of by all but the most avid students of that complex personality. In the second place, while the only direct reference to Korea is the statement that the book goes to press as "crimes against international law are once again being committed" in that theatre of combat, one cannot help but connect Japan and Korea—will there be more such trials and how far will the Tokyo Trials act as a precedent in the future? These two factors in themselves might well make the book worth the while of all who are interested in a subject of such overwhelming importance. But, in addition, the authors have done a magnificent job of presenting a complicated legal and international problem with skill, discernment, and cool-headed logic. BENJAMIN MUNN ZIEGLER. Amherst College.


Registration is an important step during prostate biopsy with interventional Ultrasound (US) to project the Magnetic Resonance (MR) information of the corresponding slice of a pre-acquired MR volume of the same patient. This paper presents a method of deformable registration between US and MR prostate modalities using Thin-Plate Splines (TPS). The use of radial-basis functions such as splines is a typical approach for deformable registration wherein, TPS are more computationally efficient than Bsplines. However, registration with TPS employs strategic choice of correspondence points in the moving and reference images and therefore, has been rarely used by researchers for prostate registration. Aiming to deal with this issue, a novel method to automatically choose correspondence points (control points) based on the prostate geometry is presented in this paper. Shepard's interpolation is used with the TPS in order to deal with the interpolation artifacts produced by reverse TPS transform. To evaluate the accuracy of our correspondence generation method, two intuitive geometric methods for prostate contour sampling are also implemented. Our registration results are validated using 4 patient datasets obtaining an average DSC of 0.97 ± 0.01.


Cupric oxide (CuO) thin film was sputtered onto fluorine-doped tin oxide (FTO) coated glass substrate and incorporated into a photoelectrochemical (PEC) cell as a photocathode. Through in situ nanocrystal engineering, sputtered CuO film shows an improvement in its stability and photocurrent generation capability. For the same CuO film thickness (150 nm), films deposited at a sputtering power of 300 W exhibit a photocurrent of ∼0.92 mAcm(-2) (0 V vs RHE), which is significantly higher than those deposited at 30 W (∼0.58 mAcm(-2)). By increasing the film thickness to 500 nm, the photocurrent is further enhanced to 2.5 mAcm(-2), which represents a photocurrent conversion efficiency of 3.1%. Systematic characterization using Raman, XRD, and HR-TEM reveals that the high sputtering power results in an improvement in CuO film crystallinity, which enhances its charge transport property and, hence, its photocurrent generation capabilities.


Nowadays, the Unified Modeling Language (UML) is becoming a "de facto" standard for object oriented environments and then it is perceived as a part of the culture of software engineers. However, the luck of rigorous semantic basis is a great shortcoming of UML which upsets its use to address safety problems. Still, taking benefit of the richness of UML to model critical systems is worthwhile because it is aimed at reducing the certification effort required for the design phase. Currently, we undertake works to delimit a well-defined UML core which could be used to model such systems. In this paper, we explore some critical aspects and recommendations of basic UML constructs which should be approached when dealing with safety.


The invention provides an air conditioning system of an oxygen cabin-type gymnasium and a working method thereof. An oxygen cabin-type gymnasium system comprises the oxygen cabin-type gymnasium, a central air conditioner fresh air supply general air conduit, an air source purifying system, an air degerming and filtering device, oxygen producing equipment, oxygen supply equipment, a carbon dioxide lower suction system and a negative oxygen ion generator. When the oxygen content measured by an oxygen measurer in the gymnasium is not more than 22%, the oxygen producing equipment starts working and supplies oxygen to the gymnasium, when the oxygen content measured by the oxygen measurer in the gymnasium is not less than 30%, the oxygen producing equipment does not work, when the CO2 content measured by a carbon dioxide meter in the gymnasium is not more than 3%, the carbon dioxide lower suction system does not work, and when the CO2 content measured by the carbon dioxide meter in the gymnasium is more than 3%, not less than 5% and not less than 6%, the weak grade, the intermediate grade and the strong grade of an exhaust fan in the carbon dioxide lower suction system work respectively. The invention has the following advantages of reasonable structure, simple operation steps, economic cost and strong practicability, and completely changes the air quality in the gymnasium so as to change the body function of a sporter.


despite progress in neonatal care and despite changing concepts in treatment in the recent years, the mortality rate of infants with congenital diaphragmatic hernia (CDH) remains high ([20][1]). Pulmonary hypoplasia and vascular alterations associated with CDH have tremendous postnatal functional


A SYMPOSIUM upon the method of evolution, participated in by students from widely, different provinces, can hardly be expected to develop, harmony of opinion. But to be assigned a place in such a discussion as a. representative of one field of endeavor does not inmply that the conclusion one reaches will necessarily differ from that of his Cosymposiasts; for the question of the method of evolution is a question of fact, and when the fact is discovered, it will be recognized as completely by the paleontologist as by the physiologist. And, in particular, to be assigned the final place in the argument does not mean that the doctrine preached will be, or even is, the last. word on the subject. In the. present state of knowledge of biology the most that can be expected of an address on this subject is a statement of principles which should -guide us in a search for the facts. Beyond these principles there are justifiable suspicions, and there may even be militant conjecture, but little else. The first fundamental principle for the guidance of one who would find the method of evolution is a principle commnion to all sciences which seelk to explain the occurrences of a remote pa.st. No agencies may be assumed to have operated fifty million years ago of a. different order from those that operate to-day. If the phenomtiena of the present afford a plausible, or even possible, explanation of the past, there must be no appeal to other phenomena, the like of which do not now exist. Just a.s a geologist mnentally constructs the rock strata a thousand feet below the surface, and the glacial drift of regions


The ability of the reticulo-endothelial system (RES) to remove activated procoagulants from the circulation may provide an important protective mechanism against thrombosis . In 11 patients undergoing major surgery, the phagocytic and catabolic activity of RES was measured using I-labelled microaggregated human serum albumin in a dose of 10μci of 125I and 5mg/kg of aggregates per test. RES function tests were performed before surgery and again exactly 24 hours postoper atively. Plasma samples were also taken for At III, fibrinogen and FOP levels. The phagocytic index and catabolic rate was determined using a computer programme. The phagocytic rate of the RES was not affected either by surgery or by low doses of heparin. However, the catabolic rate increased postoperatively in the control patients (p < 0 .00 5) and low-dose heparin prevented such an increase. The mechanism for such an effect is obscure, but it is suggested that heparin is taken up and stored by RES cells without prior degradation and that this up-take and storage slows the metabolic activity significantly. Further studies are needed to determine the importance of intra-cellular storage and release of heparin.


The invention discloses a refrigerator and a folding shelf assembly thereof. The folding shelf assembly comprises two brackets, two guide installation seats, and a shelving plate, wherein the two brackets are orientated in the up and down direction and arranged at intervals in the horizontal direction; the two guide installation seats are respectively arranged on the two brackets and are adjustable in the up and down direction in positions, the shelving plate is connected with the guide installation seats and overturn between a vertical position and a horizontal position relative to the guideinstallation seats, and the shelving plate is orientated in the vertical direction in the vertical position and can be orientated in the horizontal direction in the horizontal position. The folding shelf assembly disclosed by the invention can be freely folded or unfolded through overturning of the shelving plate according to demands, and is simple in regulation operation without dismantling the shelving plate. In addition, the folding shelf assembly disclosed by the embodiment of the invention has simple structure and low cost.


The structural evolution behavior of germanium anionic clusters doped with the rare-earth metal yttrium, YGen– (n = 6–20), has been investigated using a mPW2PLYP density functional scheme and an ABCluster structure searching technique. The results reveal that with increasing cluster size n, the structure evolution pattern is from the Y-linked framework (n = 10–14), where Y serves as a linker (the Y atom bridges two germanium subclusters), to the Y-encapsulated framework (n = 15–20), where the Y atom is located in the center of the Ge cage. The simulated PES spectra show satisfying agreement with the experimental PES spectra for n = 12–20, which reveals that the global minimum structures reported here are reliable. In particular, the anionic YGe16– nanocluster is found to be the most stable structure in the size range of n = 6–20 through analyzes of the relative stability, highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) gap, spherical jellium model, and isochemical shielding surface. Moreover, spectral properties such as infrared and Raman spectra were reported. In addition, the UV–vis spectra of the YGe16– nanocluster are in good agreement with solar energy distribution, showing that such substances serve as multifunctional building blocks to be potentially used in optoelectronic devices or solar energy converters.


The field bioassay of 4 trunk injection insecticides(14% Imidacloprid+DDVP,4.5%Imidacloprid,2%Abamectin and 30%DDVP+omethoate) was conducted against Brontispa longissima.The results showed that 14%Imidacloprid+DDVP,4.5%Imidacloprid and 30% DDVP+omethoate were efficient,and 14%Imidacloprid+DDVP exhibits high efficiency.The control effect reached 95.10% 30 days after the injection at the dose of 0.7 mL/cm trunk ground diameter.


THEOREM 1. Let K be a nonnegative Borel measurable function on Rd with f K(x) dx = 1. Then the following conditions are equivalent: (i) J -* 0 in probability as n -oo, some f; (ii) Jn -O 0 in probability as n -s oo, all f; (iii) Jn -s 0 almost surely as n -* oo, all f; (iv) Jn --* 0 exponentially as n -> oc (i.e. for all E > 0, there exist r, no > 0 such that P(JnE) no), all f; (v) lim0h = 0 and limnnhd = oo. Also, (v) implies (iv) when K is merely absolutely integrable and f K(x) dx = 1. 0


Strain based design concepts have been extensively used for subsea pipelines for both installation and service. However, most onshore transmission pipelines are designed assuming a maximum longitudinal stress, typically 90% SMYS. Some onshore pipelines have been designed for a limiting axial strain generated by causes such as seismic activity, frost heave, discontinuous permafrost or landslides. Models have been developed to predict the axial strain capacity in both tension (usually limited by the girth welds) and compression (where the limit is local buckling of the pipe wall).
 In service monitoring of a pipeline initially designed on a stress basis may reveal that strains approaching or exceeding the design level are occurring, or are predicted to occur in the future. In these cases the pipeline operator will have to assess if the pipeline is fit for continued service. In principle strain based design approaches could be adapted for such an assessment.
 Strain based design approaches place more onerous demands on the linepipe and the girth welds, but for a new pipeline these requirements can be addressed during design, material specification, procurement and weld procedure qualification. However, for an existing pipeline the data required to use strain based approaches may not be readily available. Some strain capacity models are only valid over a restricted range of inputs and so cannot be used in all cases. Hence there is a need to develop guidance for assessing the fitness for purpose of a stress based design pipeline that is found to be experiencing high axial strains.
 The European Pipeline Research Group (EPRG) has initiated a program to develop such guidance. This paper presents the results of the first stage of this program. The requirements for data such as inspection records, weld metal fracture toughness and parent pipe mechanical properties are considered. A flow chart has been developed to guide operators when assessing an existing pipeline found to be subject to high strains, and a gap analysis identifies areas where additional work is required.


State policies can support renewable energy development by driving markets, providing certainty in the investment market, and incorporating the external benefits of the technologies into cost/benefit calculations. Using statistical analyses and policy design best practices, this paper quantifies the impact of state-level policies on renewable energy development in order to better understand the role of policy on development and inform policy makers on the policy mechanisms that provide maximum benefit. The results include the identification of connections between state policies and renewable energy development, as well as a discussion placing state policy efforts in context with other factors that influence the development of renewable energy (e.g. federal policy, resource availability, technology cost, public acceptance).


This survey mainly dealing with the health issues. Their related information is collected and how important data mining is in health care. Now-ever-days health issues are increasing and recording every information are becoming more complex. Gathering the health record by gathering the data sets related to insurance claims, health surveys and other sources including data quality and privacy issues. The analysis of new health conditions using data mining is necessary. Clinical Decision Making by diagnose their issues or disease rather than by the medical experts. Bio medicine and Genetics for finding the specific diseases that are effects of genetics are studied with the help of bio medical and molecular level. Population Health focused mainly on the patterns, trends and causes of specific disease across a population. Health Administration and Policies mainly focus on the insurance plans in the area of health administration. It is believed that by analyzing the related data and extracting the hidden information out of that data, many useful and applicable solutions can be developed. With the increase of implementing electronic systems, such as electronic health records systems, in the health sector, there are massive amount of data being captured every day. Keywords—Data Mining; Health Data Analysis; Data Quality; Predictive Modeling; Health Big Data; Data Mining Applications; Classification; Clustering; Association


A supersonic mercury vapor jet has been developed for use in stripping electrons from a beam of heavy ions. The required surface densities (2 to 20 μg/cm2) were obtained with the apparatus described. The increase in pressure caused by the jet was less than 3×10−7 mm Hg at the end of a 10‐in. beam tube.


In his very informative article about the century-old lessons from syphilis,1Meyer tells us that "Calomel ointment supplanted the use of carbolic acid, which had been criticized for causing eczema and fissures of the hands, thus enhancing (with welldocumented prophylactic failures) instead of retarding the spread of infection." Meyer also says that "William Halsted (1852 to 1922) requested the Goodyear Rubber Co to make thin rubber gloves to protect his and his nurse's hands from harsh antiseptic solutions used in the operating room." With the new emphasis on washing before and after every patient contact, the same problem may be reappearing. A busy doctor can see 30 patients a day. Will any skin tolerate 60 washings, especially in the winter, when hands tend to crack and bleed? My skin won't, even though I use a scrub that contains lanolin and aloe vera, and I doubt others' will, either, judging


The influence of age at the time of exposure to aerosols of lUCeOz were studied in C57BL/6J female mice. Mice were exposed to aerosols of '"CeO, when 70, 260 or 450 days of age to achieve desired initial lung burdens of 0.2, 1.0 or 4.5pCi '"Ce. The retention of Ce after exposure and cumulative radiation doses to lung, liver and skeleton were similar in the different age groups. Less life shortening and radiation pneumonitis occurred in mice exposed when 260or 450-days-old than in mice exposed when 70 days old. Benign lung tumors occurred more frequently in the '"CeOz-exposed mice than in the controls, but there were no apparent differences among mice exposed at different ages. Malignant lung tumors occurred more frequently in the mice exposed to '"Ce02 when 70 days of age than at the other ages., It was concluded that 70-day-old mice are more sensitive to development of late occurring effects of inhaled '"Ce02 than 260or 450-day-old mice. 144


Four isoquinolone alkaloids, N-methylcorydaldine, 8a oxyhydrastinine 8b, 6,7-dimethoxy-2-methylisocarbostyril 9a and doryanine 9b, have been efficiently synthesized from phenyl vinyl sulfoxide via the Pummerer type rearrangement as a key step.


Objective To discuss the referral process and the matters needing attention of long-distance transportation in critical patients in order to ensure the smooth development of the long-distance referral.Methods The clinical data of 194 critical patients with long-distance transportation were retrospectively analyzed.Results Except1 case of death in transit,the other cases all arrived in the reception hospitals safely.The circulation and breathing of critical patients were affected by the transportation.Conclusion Smoothly conducting the long-distance transportation of the critical patients can not be separated from the advanced equipments,proficient medical technology,close coordination of first aid team,understand and support of patients' families and perfection of the emergency medical service system(EMSS)including pre-hospital first-aid,in-hospital emergency treatment and emergency ICU.


patients with ascites due to cirrhosis" were somewhat similar to those following adrenalectomy, and, although urinary levels of aldosterone always fell to normal, this was not necessarily accompanied by a rise in excretion of sodium. Amphenone is at present difficult to obtain and it causes disturbing sideeffects; in cases of severe liver disease it may precipitate hepatic coma. Yet it may well have a place in the management of those patients in whom ascites is resistant to all other forms of therapy. Retention of water and salt cannot be ascribed solely to the action of the adrenal cortex. Other hormones-for example, oestrogens-have salt-retaining activity, and these may be present in excess when the liver is damaged. J. R. K. Preedy and E. H. Aitken" showed convincingly that oestrogens could influence fluid retention, especially when the hepatic circulation was impeded. Evidence that antidiuretic hormone (A.D.H.) plays a part is more questionable, though increased antidiuretic activity has been found in the urine of patients with ascites.'6 As the cirrhotic liver is able to dispose of A.D.H. normally,"7 any increase in activity mustindicate excessive production. At the Royal Society of Medicine meeting J. Lee and G. W. Bisset reported high levels of A.D.H. activity in blood obtained from the internal jugular vein of some patients with liver disease. Assay methods are extremely laborious and the quantities measured minute, so that a larger series must be awaited before the role of A.D.H. can be assessed. The value of adrenal steroids in the treatment of liver disease remains to be discussed. It must be admitted that they play little part in the treatment of uncomplicated liver disease, either hepatitis or cirrhosis. Occasionally steroids may be life-saving for patients with fulminating viral hepatitis, and they are worth a trial for patients with hepatitis which relapses. They are also diagnostically helpful in deciding whether prolonged obstructive jaundice is due to intrahepatic cholestasis (" cholangiolitic hepatitis ") or to extrahepatic obstruction. In the former, a short course of treatment is usually accompanied by a fall in the levels of serum bilirubin and alkaline phosphatase, with subsequent clinical improvement.'8 A fall may also occur in extrahepatic obstruction, but the serum bilirubin rises again when the steroids are stopped.'9 They appear to have an action on production of bilirubin rather than a direct effect on the obstructing process. Whatever the mechanism, this method should be useful in diagnosing the small group of patients with obstructive jaundice who give rise to clinical difficulty. NEUROLOGICAL ASPECTS --OF PULMONARY EMPHYSEMA


In progeria, a mutant form of lamin A constitutively tethered to the inner nuclear membrane causes disruption of the Ran GTPase system by inducing ROS. However, ROS are also induced by disruption of the Ran system. The data suggest that the nuclear lamina and Ran GTPase system are part of a pathway that contains positive and negative feedback loops.


Individual persons are the most influential players in the online digital environment. Regarding their internet activities, these individual players could perform their role as either the original creator, the user, or the subsequent creator of the online digital works. When they are performing different roles, they are protected under different fundamental rights. For example, when online user borrows an online original works of the original creator to create online derivative works, two fundamental rights which are relevant are 'copyright' and 'the right to freedom of expression'.
The thesis focus on the rights of these online individual players in these two important aspects: copyright and the right to freedom of expression. Based on the inexplicable conflict between both rights, this thesis fundamentally argues that it is not as what was previously claimed that 'copyright is the engine of free expression'. On the other hand, it is the other way around that 'free expression is an engine of copyright'. This is following the logic of the deductive argument based on the evidence that 'free expression is an engine of creative expression' and 'creative expression is an engine of copyright'.
The argument above thus supports the importance of creativity in the copyright regime. It is thus certified that under the fundamental concept of copyright there lies a strong concept of system that protects and encourages the prosperity of human's creativity under the term of authorship. Therefore, the protection of copyright in the digital era should not be directed away from this very fundamental concept.
In terms of making online derivative works, this thesis therefore proposed that an exception of copyright infringement should be allowed for unauthorised user in so far as it encourages the prosperity of human's creativity and does not conflict with a normal exploitation of the work and does not unreasonably prejudice the legitimate interests of the author, as certified under Article 9 of the Berne Convention.
For this purpose, the thesis finally proposed that it is possible under the fundamental concept of copyright and the internet technology to create a distinction between the act of making adaptation and making publication of the online digital derivative works. This is, at least, to allow unauthorised making adaptation of the online digital works for prosperity of individual's creativity, without re-publishing of those derivative works online.


It is important to model the substrate coupling for today's mixed-signal circuit design. This paper presents the hierarchical block boundary element method (HBBEM) for substrate resistance calculation. HBBEM, which can extract the whole interconnect capacitance matrix with once computation, is applied to the substrate resistance calculation. Experiments show that the proposed method is able to produce results with comparable accuracy, and of higher efficiency than existing methods both in running time and memory usage


The diagnosis and treatment of nonsmall-cell lung cancer in advantage stage by Chinese and western medicine were reviewed and summarized,so as to analyze the usage and advantages of combination medicine,providing reference and experience for treating nonsmall-cell lung cancer in advantage stage.


The effects of different calcium levels upon germination and tube growth of the pollen of Setaria sphacelata (Schum.) Stapf and Hubbard were studied at low, optimal and high levels of boron. Calcium (10 and 100 mg/1) stimulated germination at all levels of boron and enhanced tube growth to an even greater degree. The inhibitory effects of high boron levels (50 mg/1) were largely overcome by addition of 10 to 100 mg/1 calcium. Magnesium (1 and 10 mg/1) stimulated germination and tube growth at optimal and high boron levels, but 100 mg/1 magnesium were highly inhibitory. Potassium and sodium had little effect upon pollen germination or tube growth at any level of boron supply. It was concluded that calcium, together with sucrose and borate, might be required for optimal germination and growth of the pollen tubes. Nevertheless, the tubes obtained were much shorter than required for fertilisation in vivo, indicating either that some essential factor was still missing or that the pollen is inherently incapable of producing tubes of adequate length.I wish to thank dr. Donald T. Krizek for critically reading the manuscript.


Aim To synthesize carbasalate magnesium,a new medicine which may play a role in the treatment of the cardiovascular disease.Method Carbasalate magnesium was synthsized from Asprin(acetyl salicylic acid),Mg(OH) 2·4MgCO 3·6H 2O and urea by a two step preparing method.The optimization of the production technology of carbasalate magnesium was researched,using the orthogonal test method.Results The total yield could reach 70%,purity ≥99 9%.Their structures were established by elemental analysis,IR, 1H NMR and 13 C NMR spectra.Conclusion The synthetic technique is comparably simple,with better quality of the product and lower costs.


The injection of thioacetamide into rats resulted in the release of hepatocellular-specific antigens into the systemic circulation. These hepatic proteins remained in the circulation for 1 to 2 days. Circulating autoantibodies, directed to autologous liver antigens, were detected about a week later in the sera of only 2 of the 20 rats.


In this paper, the complex-valued neural networks with both periodic time-varying delays and coefficients is considered. A sufficient criterion is established to ensure the existence, uniqueness and global exponential stability of periodic solution for the considered complex-valued neural networks. When these coefficients are constants, a stability criterion is derived to the existence, uniqueness and global exponential stability of equilibrium point. Two examples with numerical simulations are given to demonstrate the efficiency of obtained results.


Injection compression molding method of the present invention, a mold clamping state of the mold 11 at a low pressure, while moving the cavity space 13 to the gate 30, the molten state from the gate into the cavity 13 thermoplastic resin composition 16 after injected and filled, as well as the mold clamping state in the high-pressure filling completion almost simultaneously mold 11 to compress shaping the thermoplastic resin composition 16 filled in the cavity space 13. Since the thermally conductive filler such as conductive fillers can injection compression molding a thermoplastic resin composition containing a high proportion, for example, can be utilized for the production of molded articles, such as a separator for or a planar antenna fuel cells.


Watermark technology is developed to tackle the problem of unauthorized copying and distribution of digital data. Different schemes have been proposed in the last few years, but most of them are symmetric. This paper is devoted to some typical asymmetric watermarks and some basic characteristics of asymmetric watermark and symmetric watermark. This paper studies different kinds of digital watermarking algorithms based on the characters of HVS and embed the watermarks with visually recognizable patterns.


This paper surveys several mutual fund performance evaluation models. The models are applied to examine the performance of Greek equity and balanced mutual funds. Specifically, the Henriksson and Merton (1981), Bhattacharya and Pfleiderer (1983) and Lockwood and Kadiyala (1988) models are applied and compared. Empirical results show that models in which beta is treated as random variable imply superior manager performance in terms of selectivity, contrary to models based on the assumption of binary betas. All models are in agreement that fund managers do not exhibit superior macro-forecasting abilities.


The bifurcation analysis of a second-order continuous-time forest-fire impact model is carried out by resorting to a properly defined one-dimensional discrete-time system (map). The map is derived quite directly from the forest-fire model and is exploited to find out the regions of the chosen parameter domain characterized by qualitatively different behaviors. The results are compared with the bifurcation analysis carried out with a different method


With the expansion of college enrollment, the number of college students is increasing, and the amount of information to be dealt with in the information management of college students is increasing. In most colleges and universities, managing college student information is done arti"cially. In this context, how to e…ectively manage and utilize the dance big data of college students has important research value. erefore, this article takes the development and realization of student dance under the public service platform system of colleges and universities as the subject and design the university dance big data management and utilization system based on information resource sharing. Due to the high mobility of college students, this work also carries out an information resource sharing strategy to establish the dance big data management and utilization system for universities; after the implementation of the student dance big data management service system, colleges and universities can provide more convenient transfer, management, query, and other services of student "les.


"Mergers: main developments between 1 January and 30 April 2009"* On 4 February 2009 the European Commission approved, under the EU Merger Regulation, the proposed acquisition of the Czech…


Arato M. Banki CM, Bissette G, Nemeroff CB, Elevated CSF CRH in suicide victims. Biological Psychiatry 1989;25:355—359. Baker DG, West SA, Nicholson WE, Ekhator NN, KasckoW JW, Hill KK, Bruce AB, Orth DN, Geracioti TD Jr. Serial CSF corticotropin—releasing hormone levels and adrenocor tical activity in combat veterans With post—traumatic stress disorder. Am J Psychiatry 1999;156:585—588. Banki CM, Bissette G, Arato M, O'Connor L, Nemeroff CB. Cerebrospinal ?uid corticotropin releasing factor—like immunoreactivity in depression and schizophrenia. Am J Psychiatry 1987; 144:873—877. Basile AS, Hanus L, Mendelson WB. Characterization of the hypnotic properties of oleamide. Neuroreport 1999;10:947—951. Brady LS, Whit?eld HJ Jr., Fox RJ, Gold PW, Herkenham M. Long—term antidepressant administration alters corti cotropin—releasing hormone, tyrosine hydroxylase, and min eralocorticoid receptor gene expression in rat brain. Thera peutic implications. J Clin Invest 1991;87:831—837. Brady LS, Gold PW, Herkenham M, Lynn AB, Whit?eld HJ Jr. The antidepressants ?uoxetine, idazoxan and phenelzine alter corticotropin—releasing hormone and tyrosine hydroxy lase mRNA levels in rat brain: therapeutic implications. Brain Res 1992;527:117—125. Brady LS, Lynn AB, GloWa JR, Le DQ, Herkenham M. Repeated electroconvulsive shock produces long—lasting increases in messenger RNA expression of corticotropin—re leasing hormone and tyrosine hydroxylase in rat brain. Therapeutic implications. J Clin Invest 1994;94:1263—1268. Casper RC, Kocsis J, Dysken M, Stokes P, Croughan J, Maas J. Cortisol measures in primary major depressive disorder With hypersomnia or appetite increase. J Affect Disord 1988;15:131—140. Cheer JF, Cadogan A—K, Marsden CA, Fone KCF, Kendall DA. Modi?cation of 5—HT2 receptor mediated behavior in the rat by oleamide and the role of cannabinoid receptors. Neuropharmacol 1999;38:533—541. Cravatt BF, Prospero—Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA. Chemical character ization of a family of brain lipids that induce sleep. Science 1995;268:1506—1509. Cravatt BF. Giang DK, May?eld SP, Boger DL, Lerner RA, Gilula NB. Molecular characterization of an enzyme that degrades neuromodulatory fatty—acid amides. Nature 1996;384:83—87. Geracioti TD Jr, Orth DN, Ekhator NN, Blumenkopf B, Loosen PT. Serial cerebrospinal ?uid corticotropin—releas ing hormone concentrations in healthy and depressed humans. J Clin Endocrinol Metab 1992;74:1325—1330. Geracioti TD Jr, Loosen PT, Orth DN. LoW cerebrospinal ?uid corticotropin—releasing hormone concentrations in eucortisolemic depression. Biological Psychiatry 1997;42:166—174. Gold PW, GoodWin FK, Chrousos GP. Clinical biochemical manifestations of depression: Relation to the neurobiology of stress (part II of parts). N Engl. Med 1988;319:413—420. Huidobro—Toro JP, Harris RA. Brain lipids that induce sleep are novel modulators of 5—hydroxytryptaine receptors. Proc Natl Acad Sci USA 1996;93:8078—8082. KasckoW JW, Regmi Gill PS, Parkes DG, Geracioti TD. Regulation of corticotropin—releasing factor (CRF) messen ger RNA and CRF peptide in the amygdala: studies in primary amygdalar cultures Endocrinology 1997;138:4774—4792. Lerner RA, Siuzdak G, Prospero—Garcia O, Henriksen SJ, Boger DL, Cravatt BF. Proc Natl Acad Sci USA 1994;91:9505—9508. Lister RG. The use of a plus maze to measure anxiety in the mouse. Psychopharmacology 92: 180—185, 1987. Mulchahey JJ, Regmi A. Sheriff S. Balasubramanian A, KasckoW JW. Coordinate and divergent regulation of corti cotropin—releasing factor (CRF) and CRF—binding protein expression in an immortalized amygdalar neuronal cell line. Endocrinology 1999;140: 251—259. Nemeroff, C.B., Widerlov E, Bissette G, et al., Elevated concentrations of CSF corticotropin—releasing factor—like immunoreactivity in depressed patients. Science 1984;226:1342—1344. Sachar EJ. Corticosteriods in depressive illness: II. A lon gitudinal psychoendocrine study. Arch Gen Psychiatry 1967;17:554—567.


A method for forming a semiconductor device having a fin structure includes (a) forming a device isolation film over a silicon substrate to define an active area, (b) etching silicon substrate of gate forming region to form a trench, (c) selectively etching the device isolation film of a trench boundary, (d) forming a gate oxide film over the entire surface of the resulting structure, (e) depositing an electrode material over the entire surface of the resulting structure to form a gate electrode, and (f) forming a gate spacer over a sidewall of the gate electrode.


At-rest lateral stress coefficient that is used for the evaluation of geotechnical structures such as foundations and retaining walls plays a significant role in the analysis and design, as a state variable of in-situ stress condition. In the widely applied Jaky's Ko equation stress condition can be inferred from the internal friction angle obtainable from the laboratory experimentation whereas the eguation mares it challenging to evaluate the influences and criteria of particle characteristics which is essential for the application of friction angles in practices. Thus, this study experimentally explored the behaviors of Ko depending on the relative density, particle shape, and surface roughness effect during a range of loading stages. The Ko values of Jumumjin sand, glass beads, and etched glass beads were measured using a customized Ko device housing strain gauges during loading-unloading-reloading steps, and the effect of dominant factors on Ko is analyzed. Results show that the high Ko prevails for both round and angular specimens with low relative density and the surface roughness has a nominal effect. The angular particles exhibit low Ko for specimens with similar relative density. The characteristics of relevance between Ko and friction angles with varying relative density are also investigated based on the experimental results using empirical correlations and previously reported values.


The invertebrate trace fossil record in the Malhada Vermelha Basin, although recognized, is quite sparse and poor from the Systematic Ichnology approach. Field researches carried out in this basin found the presence of these structures which are studied and taxonomically identiied in the current work. The absence of wall lining and the presence of a meniscate backill characteristic of Taenidium barretti allowed assigning this ichnospecies to the analyzed samples. These traces are ascribed here as the result of bioturbation activity in moist sediments exposed to subaerial conditions in paleoenvironmental features of a hot climate.


Fog removal from a single foggy scene is a tedious piece of work. Some of the existing methodologies are based on various constraints and assumptions to evaluate fog free image or defog image. Recent researchers have applied deep neural network algorithms to calculate defog image. Motivated by the recent works, this paper aims to estimate fog free image entrenched on Convolutional Neural Network (CNN). Different haze relevant features are learned using deep architecture of CNN. Using these extracted features, final defog image has been estimated. Results are compared with the existing methodologies for analysis purpose as well.


Radio signal path loss is a particularly important element in the design of any radio communication system or wireless system, and it is necessary to be able to determine the levels of the signal loss for a give radio path. The more accurate model the better decision making will occur for the network rollout, planning and optimization. The radio signal path loss could be estimated by many elements of the radio communications system in particular the transmitter power, and the antennas, especially their gain pattern, height, azimuth and also are highly influenced by clutters (land use), terrain height and morphology, spatially related parameters. Okumura-Hata empirical model, which has many parameters, is the most common model for prediction and estimation of this complicated phenomenon. On the other hand, geostatistical techniques offer interpolation methods for describing the continuity of spatially/temporarily variable data which is essential feature of many natural phenomena. Over the last decades, this theoretical framework has been successfully applied in other type of spatial problems (Konak, 2010). As it is mentioned above signal path loss is highly influenced by spatial parameters, therefore geostatistics has high potential to be implemented for such purpose (Arpee J. et al., 2000). There are few researches conducted using geostatistical techniques for modelling wireless propagation models. In a recent paper, Konak (2009) reports that ordinary kriging is competitive with radial basis ANNs to estimate the signal-to-noise ratio in cellular wireless networks. Konak in 2010 extends the ordinary kriging approach proposed in 2009 by considering path loss due to obstacles and other factors in indoor environments. In this paper we have compared the result of different spatial and non-spatial interpolation techniques with Okumura-Hata empirical model to evaluate geostatistical analysis capability to find a way of having more accurate mobile coverage models. As the result, this research will help us to have RF path loss trend estimation which is extracted from sampled data to describe data variability across the entire cellular system areas. The area of interest is a city in west of Iran. Okumura-Hata, Inverse Distance Weighting (IDWa non-spatial interpolation technique) with different power and number of neighbour and different type of kriging (ordinary & universal) with different semi-variogram model and GeoComputation 2011


We study the geometric aspects of two exotic bialgebras S03 and S14 introduced in math.QA/0206053. These bialgebras are obtained by the Faddeev–Reshetikhin–Takhtajan RTT prescription with non-triangular R-matrices which are denoted R03 and R14 in the classification of Hietarinta, and they are not deformations of either GL(2) or GL(1|1). We give the spectral decomposition which involves two, respectively, three, projectors. These projectors are then used to provide the baxterization procedure with one, respectively, two, parameters. Further, the projectors are used to construct the noncommutative planes together with the corresponding differentials following the Wess–Zumino prescription. In all these constructions there appear nonstandard features which are noted. Such features show the importance of systematic study of all bialgebras of four generators.


It is reported that the development of small-sized townships is urbanization of the countryside in China. Issues calling for special attention are putforward. Five steps are suggested as follows: formation of tertiary industries;improvement of people's living condition; process of urbanization in the countryside, motivation for making more profit; and orientation of policy and supportfrom the government. Finally, the countermeasures for the construction of small-sized townships in West China are put forward.


When exploring possible IT solutions to business problems, one of the key questions that should be asked early in the process is whether it makes more business sense to either build the solution entirely, buy an off-the-shelf package and integrate it, or some combination of build and buy. For many companies, this decision can be just as time-consuming, labor and cost intensive as the actual development itself. It is our belief that, as a key strategic decision, the buy vs. build process should make every effort to leverage the strengths of Agile. By applying Agile techniques to the buy vs. build process, organizations are able to accelerate and focus the decision-making process. Ultimately, the marriage of Agile and buy vs. build allows teams to maximize value to the business and keep the product development cycle as "agile" as possible. In this paper, we will explore our experiences in applying Agile techniques to help in this key decision. Examples will be provided from our experiences to date that illustrate how Agile can be used to address the buy vs. build question.


The biological effect of DES (diethylstilbestrol) administered during the organogenetic period of pregnancy is teratogenic rather than carcinogenic. A series of 420 women exposed to DES during the 1st trimester of pregnancy were studied. Colposcopic examination revealed that the original squamocolumnar junction occurred in the vagina in 82% of the cases. During the process of squamous metaplasia, there is danger that neoplastic transformation by carcinogens may occur in the vagina or cervix. Reports of the incidence of squamous intraepithelial neoplasia in DES-exposed women vary widely due to differences in patient selection, numbers in the series, and histologic interpretations. Diagnostic accuracy may be improved through the use of spectrophotometric evaluation of DNA content. The possibility that DES-exposed women have a higher risk of squamous neoplasia should be considered.


The early decades of the twenty-first century may turn out to be the time when supranational adjudication comes of age. Jenny Martinez recently observed that "there are now more than fifty international courts, tribunals, and quasi-judicial bodies, most of which have been established in the past twenty years." Curtis Bradley notes that "[i]ncreasingly, in terms of the subject matters that they address and the ways in which they are structured, international adjudicatory institutions are resembling traditional domestic courts rather than simply interstate arbitral mechanisms." And private litigants are asking domestic courts to enforce the judgments of international bodies with increasing frequency.


Refractive index n(T) and absorbance A(λ) of NaCl, MgCl2, and Na2SO4 solutions are measured and compared with the values obtained from artificial and natural seawater.


Identifying vulnerable plaque is important for preventing an acute coronary event. The present study examined the relationship between the clinical presentation of coronary artery disease and the plaque characteristics of nonculprit segment assessed by virtual histology intravascular ultrasound (VH‐IVUS).


This paper argues that ecological frameworks offer a powerful way of explaining the take-up of information and communication technology (ICT) in schools. Past research has focused on teachers and their willingness and readiness to use ICT but this has not satisfactorily explained the use (or non-use) of ICT. Gaps in this research can be addressed by an ecological approach which shifts attention from the teacher to the context in which ICT is expected to be used. Such an approach, following Bronfenbrenner and others, looks at the relationship of individuals to the system in which they act, a relationship which is seen as interdependent. An ecological perspective explains how take-up of ICT is influenced by the degree to which different levels of a system, eg, micro, meso, exo and macro levels, are aligned. It is recommended that researchers and policy makers should pay greater attention to context when advocating the use of ICT.


Immune checkpoint inhibitors have revolutionized cancer treatment but have been associated with severe adverse cardiac events including myocarditis. CD40 agonist (CD40ag) antibodies are immune regulators that have emerged as promising candidates with remarkable efficacy across tumors including those thought to be resistant to established ICIs. To investigate CD40 signaling and its potential for adverse cardiac events, C57BL/6J, CCR2-GFP, and CCR2-knockout mice were injected with CD40ag or isotype antibodies for 7 days. Flow cytometry showed a specific increase in CCR2
 +
 macrophages that was independent of monocyte recruitment. There was no change in neutrophil recruitment and only a modest increase in dendritic cells was evident. We also observed a significant expansion of CD4 and CD8 T-cells that displayed an effector memory phenotype. Bulk cardiac tissue gene expression analysis (Figure A) revealed that CD40 activation upregulates multiple inflammatory cytokines (Ifng, Tnf, Il-12β) and chemokines (Ccl3, Ccl5, Ccl7, Cxcl9, Cxcl10), which are regulated by interferon gamma and coordinate the activation of APCs and T-cells. Finally, RNA in situ hybridization (Figure B-C) demonstrated increased levels of Cxcl9 (red) expression in cells consistent with CCR2
 +
 (white) macrophages when comparing isotype control to treatment with CD40ag. These findings reveal that CD40 activation results in a robust expansion of CCR2
 +
 macrophages and activation of T-cells within the heart, initiating a feed forward loop of activation that is mediated by interferon gamma and generates inflammatory cytotoxic mediators that may lead to myocardial injury.


This chapter contains sections titled: 3.1 The General Game, 3.2 The Monotone Game, 3.3 Communication Complexity and Formula Size, 3.4 Synchronized Protocols, 3.5 Consequences


ABSTRACT Four experiments investigating the effects of physical and social variables on the production of pointing in infants 10 to 18 months old are described. In the first two experiments, which were primarily concerned with the relation between reaching and index finger pointing, physical dimensions such as distance between baby and target objects were manipulated. Vocalization and the social communicative intentions of the pointing babies were measured. The third and fourth experiments concerned the role of the social context on the production of the pointing gesture. The third experiment compared the incidence of pointing in the presence and the absence of the mother in order to determine whether production of the gesture by the infant implies a recipient of the message. The fourth experiment compared the incidence of pointing in babies when the mother was the partner with the incidence of pointing when another infant was present. Results supported the view that pointing is, from its inception, a form of shared reference. An intrinsically social gesture, it is associated with visual checking with the social partner. It is used in infant-to-infant inezaction and is not produced if there is no one around. Findings are discussed in terms of an early capacity of sharing reference and certain aspects of social understanding shown by infants. (RH)


In this paper, we propose an estimation method of the parameter in an exponential distribution based on a progressive Type I interval censored sample with semi-missing observation. The maximum likelihood estimator (MLE) of the parameter in the exponential distribution cannot be obtained explicitly because the intervals are not equal in length under the progressive Type I interval censored sample with semi-missing data. To obtain the MLE of the parameter for the sampling scheme, we propose a method by which progressive Type I interval censored sample with semi-missing data is converted to the progressive Type II interval censored sample. Consequently, the estimation procedures in the progressive Type II interval censored sample can be applied and we obtain the MLE of the parameter and survival function. It will be shown that the obtained estimators have good performance in terms of the mean square error (MSE) and mean integrated square error (MISE).


Cyanide hydratase [E.C. 188.8.131.52] is an intracellular enzyme detected in few fungi and bacteria. It catalyzes the reaction of hydration of cyanide, a potent toxin, to form formamide, a non-poisonous amide intermediate of cyanide degradation. When asked to name a poison, everybody nominates cyanide. This evil reputation of cyanide worth paying attention because of its increasing occurrence due to natural synthesis and also due to the large scale industrial production of inorganic cyanide as CN and HCN as well as organic cyanides as nitriles, RCN. As cyanide is highly toxic, it must be detoxified in the effluent before discharging into the sewers. Although several processes of cyanide detoxification are available, the biological treatment of cyanide waste is cost-effective and ecofriendly. Cyanide hydratase is becoming important green catalyst for this process, which converts cyanide into formamide and ammonia without employing extreme conditions of reaction temperature and hydrogen ion concentration. The present project was undertaken with the view of approaching to the bioremediation of cyanide effluent. Potential cyanide degrader actinomycetes, identified as Micromonospora braunna was isolated and acclimatized in the minimal medium containing 1000 ppm cyanide. The detection of formamide in the culture broth confirmed the cyanide hydratase activity. 76.66 enzyme units were detected in the production broth supplemented with dextrose as carbon source and potassium cyanide as sole nitrogen source. The enzyme cyanide hydratase was extracted and its reaction parameters were determined. The kinetics studied revealed the Km value as 33mM and Vmax 39 μmoles/ml/min.


Let C be a category of (pointed) spaces. For $X, Y \in C$ we denote the wedge (or one point union) by $X \vee Y$ and the cartesian product by $X \times Y$. Let $Z \in C$; we say that Z cancels with respect to wedge (resp. cartesian product) and C, if for all $X, Y \in C$ the existence of a homotopy equivalence $X \vee Z \to Y \vee Z$ implies the existence of a homotopy equivalence $X \to Y$ (resp. for cartesian product). If this does not hold, we say that there is a non-cancellation phenomenon involving Z (and C).


Recent evidence indicates an increased prevalence of intravenous opioid drug abusers (IVDAs) among supraglottic squamous cell carcinoma (SG‐SCC) patients. This study investigates whether the clinical course of SG‐SCC in IVDA differs from SG‐SCC in non‐IVDA.


Abstract Background: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia due to renal phosphate wasting. An overproduction of the phosphatonin fibroblast growth factor 23 (FGF-23) has been implicated in TIO pathogenesis. FGF-23 increases renal phosphate excretion by reducing the expression of sodium-dependent phosphate co-transporters NPT2a and NTP2c in the proximal tubules. TIO is most commonly associated with mesenchymal tumors. Epithelial tumors are estimated to account for only 5% of reported cases of TIO. Here we report a rare case of TIO associated with castration resistant metastatic prostate cancer. Clinical Case: A 59 year old male with high grade castration-resistant metastatic prostate adenocarcinoma presented with worsening fatigue and bone pain. Nine years before presentation, he was treated with prostatectomy, pelvic radiation, and taxotere followed by one year of luteinizing hormone-releasing hormone (LHRH) agonist. Bony metastases were identified 8 years later, and he was treated with a combination of LHRH agonist, RANK-ligand inhibitor denosumab, antiandrogenic therapy abiraterone and prednisone. Due to refractory disease, he received three cycles of sipuleucel-T, a cell-based cancer immunotherapy, and was enrolled in a phase 1B clinical trial involving enzalutamide. Laboratory evaluation included phosphorus 1.2 (2.5-4.5 mg/dL), urine phosphate excretion 1984 (400-1300 mg/24 hour), parathyroid hormone 110 (15-65pg/mL), calcium7.9 (8.7-10.2 mg/dL), vitamin D-25 85.3 (30-100mg/dL), inappropriately low vitamin D 1,25 40 (19.9-79.3 mg/dL) and FGF-23 387 (44-215 ref units/mL). Whole body scan showed widespread osteoblastic metastatic lesions. He was treated with high-dose calcitriol, vitamin D, calcium carbonate, and potassium phosphate with improvement in hypophosphatemia and bone pain. Clinical Lessons: Hypophosphatemic osteomalacia in the setting of advanced prostate cancer was first reported in 1975. The role of FGF-23 as a phosphatonin in such cases has since emerged, due to advancement of laboratory assays and improved understanding of the pathophysiology of TIO. Review of existing literature reveals five reported cases of prostate cancer-associated TIO with associated elevated FGF-23. This condition poses a diagnostic challenge, as TIO-related bone pain and weakness can be mistaken for that associated with bony metastases. Given the inability to resect widely metastatic disease, treatment of such cases consists of reducing tumor burden with chemotherapy and radiation and supplementation with calcitriol and phosphorus. While other FGF pathways have been implicated in prostate cancer-related angiogenesis, drug resistance, and metastases, the role FGF23 may play in an aggressive disease course warrants further investigation, particularly given it may represent a treatment target.


In many practical engineering applications, the number of actions that have been finished should be known, particularly for an untrimmed video sequence that includes an event with a series of actions, it is important to know the number of actions that have been finished. In this paper, we termed this process as visual event progress estimation (EPE). However, the research related to this problem is few in the research community. To solve this problem, a visual human action analysis-based framework, namely one-shot simultaneously action detection and identification (SADI)-EPE, is presented in this paper. The visual EPE is modeled as an online one-shot learning-based problem; sliding window and attention-based bag of key poses formulate our framework. Unlike most of the action analysis methods relying on a number of training data of some predefined classes, our method can realize SADI for any event if one sample of the event is given, which makes it feasible for practical applications. At the same time, not only SADI but also the progress estimation of the event can be realized by our algorithm. In terms of methodology, the key pose is defined by an invariant pose descriptor from skeletal data and silhouette data. Moreover, in order to extract representative and discriminative poses from one training sample, we present a new bidirectional $k$ NN-based attention weighted key pose selection method, which can filter the unrelated actions and model different importance of various key poses. In addition, an attention-based multi-modal fusion scheme, which addresses the difficulty of high-dimensional features and few training samples, is proposed to augment the performance of our algorithm. Finally, we propose an evaluation criterion for the estimation problem. Extensive results demonstrated the efficacy of our proposed framework.


FIELD: food industry. SUBSTANCE: invention relates to a food product granulated component applicable, in particular, as an admixture to a milk product. The food product granulated component includes a filler and a coating. The filler is a food semi-product piece representing a fluid at room temperature and chosen from the group consisting of fruit semi-product pieces, other semi-product pieces chosen from the group consisting of semi-product pieces of honey, nuts, cocoa, defatted cocoa, chocolate, coffee, vanilla and their mixtures. The coating contains a layer consisting of a component chosen from the group consisting of food cocoa and chocolate products as well as food additives with hydrophobic effect, in particular, in case of necessity, flavoured and/or coloured food fats or fat-containing substances with fat content equal to 80 % or more or their mixtures. The mean diameter of the food product component granules is equal to 6-18 mm, preferably, 8-11 mm. The food product component is essentially in a sterile form. EFFECT: invention allows to manufacture a product attractive in terms of taste and sensation. 16 cl, 1 dwg, 1 ex


This paper mainly discussed some special requiremen ts for communication system and specific implement methods during the cause of cam paign cooperation in modern times. That system is the Advanced Field Tactical Da ta System which was developed to meet the requirements for controlling every fir e nodes, through which Army can achieve their campaign and tactical goals. The c ourse of dealing with communication message mainly include Emery's situation rep orted, Message change (generally referred to taxis and how to choice best ways), Fire distribute, Evaluating for enemy's casualty, cooperation among all fire no des, etc. The primary focus for this paper is how to deal with overall throughp ut, message latency, immunity from transmission errors, terrain effects on links and jamming. The system must balance all of these factors to provide within lit tle delay and that some messages are received with a specified time, finally we can make all fire nodes have best control in order to realize the aim of make th is system more optimized.


Hydraulic transmission used in performing mechanism has been widely app- lied to the system of automatic electrode regulation in modern steel-melting electric-arc-furnace with the basic theory of classical control,this paper made a preliminary analysis of the system.Moreover,on the base of a math- ematical model of the system,a designing method of automatic electrode reg- ulators is put forward.


The electrostatic interactions between spherical particles suspended in an electrolyte solution is analyzed. The surfaces of these particles are coated with an ion‐penetrable membrane, which bears nonuniformly distributed fixed charges. We consider two classes of fixed charge distributions; these distributions all yield the same amount of total fixed charges in the membrane phase. The exact solution to the governing Poisson–Boltzmann equation is derived for the case the potential of the system under consideration is low. Based on this solution, the stability ratio and the critical coagulation concentration of a dispersed system are estimated.


The utility model relates to a theft-proof mobile phone which can control the shutdown and install and uninstall a cell and a mobile phone card. A password shutdown chip and a locking device for a cell panel and the mobile phone card are arranged in the mobile phone. The mobile phone can be shut down only by the password. The locking device which can be unlocked by a key comprises a lock bar, a lock body, a rocker, a spring, a lock core and a lock tongue plate which is integrated with the cell panel. Only a matched key can unlock the locking. A locking device of a password electronic unlock comprises a lock bar, a lock body, a spring, a magnet coil, an iron core and a lock tongue plate which is integrated with the cell panel. The upper end of the iron core which is movably inserted in the magnet coil is hinged with the lock bar. A password unlocking chip which is connected with the magnet coil is arranged in a mobile phone core. Only with password, the magnet coil can be electrified to unlock the lock and rescind the locking. A theft can not shut down the mobile phone after robbing the mobile phone and cannot uninstall the cell and the mobile phone card, let alone disassemble and renew the mobile phone. Therefore, the mobile phone is easy to be found or the theft feels the mobile phone is useless, and the actions of stealing mobile phones can be gradually eliminated.


A method of metal flow, load and strain prediction in forming operations is presented. Based on the upper-bound elemental technique, it is applied to hot forging operations where a constant flow stress can be assumed and also to cold working of aluminium and steel where the effects of strain hardening are taken into account. The predictions were found to be in reasonable agreement with experimental results.


Vaginal bleeding in the first trimester is a frequent cause of concern to the patient and her obstetrician. With the advent of ultrasonography, a high percentage of these patients are now being evaluated sonographically. We report a case with an extensive intrachorionic collection of blood that initially was misinterupreted as an intrauterine embryonic demise. A viable fetus was detected one week later.


The entry point to the debate concerns whether the rate of profit has risen or not since the early 1980s, notably in the United States which most contributions focus on. Graphic 1 below summarises and updates the results of previous works. Both in the USA and in the three main European countries, we can clearly distinguish two periods: a fall in the rate of profit until the early 1980s, then a rise. It can be noted that the fluctuations are most marked in the USA where the rate of profit falls from 2007 onwards, and this before the crisis moreover (Husson 2009b). But the tendency is certainly there.


Defining emotional and psychological abuse emotional and psychological abuse - knowing and feeling towards the definitions of emotional and psychological abuse emotional and psychological abuse in a global, cultural and historical context case histories of emotional and psychological abuse the parents of emotionally and psychologically abused children emotionally and psychologically abused children - observation, communication and assessment the emotional and psychological abuse of Michelle implications for management and trainers.


Several sequential deposition processes for Cu(ln,Ga)(S,Se), leading to highly efficient thin film solar cells are described. Secondary phases and interdiffusion determine the growth mechanism of a process consisting of InSe, and Cu deposition at a low substrate temperature followed by a high temperature selenization step. Complex phase transitions are involved in the formation of CulnS, by this inverted process. The presence of a secondary CuS phase leads to a complete recrystallization of the film. Alloys of CulnSe, with CulnS, can be formed with the inverted process. Devices based on these absorber layers exhibit efficiencies up to nearly 16% for Cu(ln,Ga)Se, and nearly 12% for CulnS,.


Mapping accurate satellite images from street view is a challenging image-to-image translation task. Recent advances in Generative Adversarial Networks (GANs) have shown promising results in image-to-image translation. Pix2Pix is a generalized framework for image-to-image translation which uses Conditional Adversarial Networks. It has performed well on a large number of datasets. However, it uses a simple pixel-level reconstruction loss due to which the output suffers distortion in some cases. In this paper, we propose SatGAN, which is based on Pix2Pix but adds the perceptual reconstruction loss with the pixel-level reconstruction loss to produce colourful and blur free images. The perceptual reconstruction loss forces the Generator to generate samples having a similar feature representation with that of the ground truth. We experimentally prove that SatGAN produces both qualitatively and quantitatively better results than Pix2Pix for street-view to satellite dataset.


A synchronous multifrequency optical network architecture (SYMFONET) is proposed. It uses practical high-density wavelength division multiplexed direct detection components, and will enable 10–100 Gbit/s of packetised data to be switched with extremely low latency.


The invention discloses a distributed storage system and a method for downloading files thereof. The method for downloading files comprises the steps that a metadata server receives a URL for requiring to download a file from a client end, a data server where file blocks of the file are placed is inquired through the ID of the file, and the data server where the file block with the low load is placed is used as a main file downloading server to generate a new URL; the URL required by the client end is oriented to the new URL again; the main file downloading server downloads other file blocks which are not arranged in the main file downloading server from other data servers, and the file blocks of the file are sent to the client end in sequence. According to the distributed storage system and the method for downloading files thereof, uniform URL oriented metadata servers are provided for the outside, the metadata server is oriented to the main file downloading server again, and the needed files can be downloaded only by using an HTTP request once.


Introduction: Gasa crater is the result of a recent impact event in Mars latest Amazonian, approximately 1.25 Ma, and coincident with the last glacial phases of Mars most recent ice age. During the most recent ice age (2.10.4 Ma) an ice-rich mantling deposit was emplaced equatorward to the mid-latitudes. Meltwater from degradation of this deposit has been implicated in gully formation. The fresh morphology of Gasa crater provides an ideal contrast between dry mass wasting processes that have dominated downslope movement on the equator-facing slope and the gullied pole-facing slope, which has developed a large bajada. We suggest that this asymmetry is due to the insolation-dependent degradation of local ice and snow deposits. These gullies indicate that the development of extensive gully systems can occur on a timescale of perhaps a few hundred thousand years. Geologic Setting: Gasa (35.72°S, 129.45°E) is a very fresh ~7-km diameter impact crater which occurs within the simple to complex crater transition on Mars [1] with a crisp rim-crest, a well-defined flat floor, and no evidence of substantive infilling (depth-diameter ratio of 0.12). Gasa is located within an older ~18-km diameter crater in eastern Promethei Terra on Noachian cratered terrain. The outer (un-named) host crater has muted topography, a low depth:diameter ratio (0.07), evidence of latitudedependent mantling, gullies, and polygonally patterned ground [e.g., 2] which are all evidence of extensive Amazonian modification [e.g., 3]. Rays: Radiating from Gasa are extensive ray patterns (Fig. 1) visible in nighttime THEMIS infrared data [4]. The population of rayed craters, like Gasa, on Mars is limited [5]. Generally, the distinctiveness of crater rays arises from both compositional and maturity differences [e.g., 6]. The thermophysical distinctiveness of martian rays [5,7,8] is attributable to thermal inertia differences with surrounding terrain (low TI rays) hence rays are most apparent in nighttime thermal infrared data [9]. The distribution of identified rayed craters [5] suggests that the occurrence or persistence of rays is dependent on substrate. Intermediate to high background thermal inertia and intermediate albedo appear to be the important criteria regarding the distinguishability of rays (see mapping results of Mellon et al. [10] and Putzig et al. [11]). This is consistent with most of the Tornabene et al. [5] detections occuring in volcanic terranes. Rays on Mars can be homogenized with the surrounding environment or obscured from view by multiple geomorphic processes known to be active on the martian surface. To date, Gasa crater (Fig. 1) is located farther poleward (35.7°S) than any other identified rayed crater. The absence of identified rayed craters in the mid and high latitudes is consistent with recent resurfacing events in these regions due to deposition of latitude-dependent mantling deposits, which are discussed further below. Figure 1: THEMIS (Thermal Emission Imaging System) nighttime thermal infrared data show a pattern of fresh rays emanating from the ~7-km-diameter inner crater (Gasa).


This paper mainly compares and studies three target detection algorithms-YOLOv5, KCF algorithm and the enhanced KCF algorithm with Kalman Filter. The features, advantages and disadvantages of these algorithms are summarized. Also, this paper proposes a combined target detection algorithm that uses YOLOv5 to identify the target in the first frame and enhanced KCF algorithm with Kalman Filter to track the target in the following frames. The proposed algorithm is tested and validated on an open-source infrared small target dataset. The results show that the proposed algorithm can achieve a high recognition rate without consuming too many computational resources, and it is especially robust compared to pure KCF algorithm when dealing with jerky videos.


Calibration can greatly increase the utility of collecting seafloor backscattering strength with multibeam echo sounders (MBES). A calibration procedure to determine high resolution, three dimensional transmit and receive beam patterns of a Reson SeaBat 7125 MBES was performed using the fresh water calibration tank at the University of New Hampshire. The measurements employed an omni-directional Reson TC4034 projector/hydrophone as a reference transducer at an acoustic distance of 13 m. The multibeam sonar system was configured for 256 beams equi-angle mode and operating frequency of 396 kHz. The transmit beam pattern was computed for across-track angular range between +/-90° in 0.1° increments and along-track angular range between +/-2.55° in 0.09° increments. Receive directional characteristics were measured for the across-track range of +/-120° in 0.1° increments with along-track angular range of +/-1.23° in 0.18° increments. With these measurements, a three-dimensional plot of the transmit beam pattern was computed for the entire range of angles, although for the receive beam pattern it was only determined for the 0° along-track angle. The reduced angular coverage of the receive beam pattern was due to discrepancies in the off-axis results that are thought to be related to receiver saturation. Measurements for the transmit beam pattern show a -3 dB beamwidth of 0.99° for across-track angle of 0° with side lobes below -17 dB. The results show an unexplained curvature in the transmit beam pattern that would have gone un-noticed during a two dimensional beam pattern measurement. An interference effect causing ripples and attenuation of the transmit beam pattern was also observed. This effect is thought to be caused by a second 200 kHz projector mounted parallel to the 396 kHz projector. This interference occurs at an across-track angular region between +30° and +75° with gradual decrease in amplitude of about 3 dB. The receive beam pattern measurements show a -3 dB beamwidth of approximately 0.62° for the most inner beams (beams 128 and 129) and of approximately 1.40° for the most outer beams (beams 1 and 256) at along-track angular position of 0° with side-lobes below -26 dB for the most inner beams and below -17 dB for the most outer beams.


Introduction: Here, we present a case of macular hole (MH) reopening after an initial successful closure with an inverted internal limiting membrane (ILM) flap procedure.

 Case Report: The patient was a 72-year-old Hispanic male who presented with decreased vision in the right eye who was found to have a 431 μm, full-thickness macular hole. The patient underwent three separate 25-gauge pars plana vitrectomies to correct the macular hole. The first involved an inverted ILM flap technique, the second one removal of the flap and the third one subretinal injection of balanced salt solution (BSS).

 Conclusion: The failure of the inverted ILM flap, we believe, was primarily due to the inferiorly attached flap being pulled down by surface tension of the rising fluid level.


The survey was conducted to evaluate the occupational exposure of workers to ethylene oxide (EtO). EtO is used to sterilize heat- and/or moisture-sensitive medical and surgical supplies, and exposure to EtO may occur during the sterilization process. Personal breathing-zone and general-area sampling for EtO was conducted by NIOSH researchers during the survey. Six personal short-term EtO sampling results (ranging from <0.01 to 0.80 parts per million (ppm) were below the NIOSH short-term recommended standard of 5 ppm for a maximum of 10 minutes per day. Recommendations concerning work practices and installation of engineering controls are offered that could reduce EtO exposure potential in the hospital.


This presentation shared some case studies, interesting pedagogical challenges intersecting with learning technologies, and new and better way of doing things that does not always involve buying new or expensive tools/licensing at Georgetown Qatar. It highlighted ideas, technology, and use case scenarios in the areas of Learning Management Systems, Eportfolios, Instructional Continuity, Survey software, Digital Clickers, Digital Rubrics and Media Collaboration Tools. It also focused on examples of current and future potential collaboration between Georgetown DC and Doha campus in relevant areas of Educational Technology.


finishing materials . The apparatus had becn developed by the author for evaluating fioor vibrations caused by hun 旧 n walki .At first ,verti 〔ra1 laads applied t〔)n 〔x 〕rs by walki people and the apparatus , and floor vibrations caused by walking , were measllred and colllpared by using some finishing materials . Secondly, from the result of the nieasurement and the comparison , it has been shown thaし the vibrations were hcard!y influenced by finishiiig materials .As a result ,the methQd of measuri floor vibrations directly after removirlg finishing materials from floors, was estabhshed for the


Radiomics has shown promising results in the diagnosis, efficacy, and prognostic assessments of multiple myeloma (MM). However, little evidence exists on the utility of radiomics in predicting a high‐risk cytogenetic (HRC) status in MM.


Seismic acquisition on land is expensive. Even small improvements in data quality can be costly in terms of
increased field effort. Instrument performance should never be allowed to become a limitation, and for this
reason digital systems have been designed to record to an accuracy which more than matches the potential of
processing techniques. However, the system is no better than its weakest link and it is therefore desirabie that we identify this and avoid practices, however standard these may have become, which place unnecessary restrictions on recording fidelity.
When specifying a seismic system, we need to give particular attention to the performance of the analogue
elements between ground motion (or water pressure ) and the analogue-to-digital converter. Digital specifications are robust and easily checked, but specifications at the analogue 'front end' can be ambiguous or misleading and can be difficult to verify, especially in the field. This part of the system calls for careful consideration, especially of its performance at low frequencies.
One of the characteristics of land seismie data is the high content of source-generated and other noise which travels in various surface modes. This noise is usually of lower frequency than most of the signal and may, at the points of detection, be stronger than the signal by orders of magnitude. This is particularly the case where surface sourees are employed.
The industry-wide popularity of geophones with natural frequencies of 8 to 10 Hz suggests a lack of adequate consideration for the problems which surround this analogue interface. The following offers
three separate arguments which favour natural frequencies approximately an octave higher than those
popularly in use. These relate to:

(1) Low-frequency performance of the geophone.
(2) Low-frequency performance of the analogue 'front
end' electronics.
(3) High-frequency spurious modes within the
geophone.
Each of these arguments is, of itself, convincing. Taken together the case for higher frequency geophones
appears to be unanswerable. The popularity of the lO-Hz geophone remains unchallenged through much of
the seismic contracting industry because its disadvantages are rarely acknowledged.