Now-a-days blind people and low vision people are suffering with many problems. Some of the problems they face in their daily activities are reading, identifying the objects and especially they are facing the problem to identify their medicine while they are buying from the medical stores. Blind people and low vision people face the problem while consuming medicines at home for this they depend on other people taking the inappropriate medicines is dangerous for an individual. At present everyone are using the hardware devices such as smart phones in their day to day life. So there should be some application in the smart phones which helps the visually impaired people and old people to detect the text in order to identify the medicine. Our vision is to design an application that helps the visually impaired people to scan the image and convert the detected text in to voice message. Google vision library is used to develop an application on android platform which mainly contain three important functionalities which are Text Recognition, Text Detection and Converting Text To Speech. Scanning the medicine image is done by using an in-built camera and application developed in the smart phone.


Scenes in Wellington of people lining the streets (possibly waiting for a parade). Frames 1 and 2 were taken looking at Perrett's Corner (corner of Manners and Willis Streets) showing the crowds, and frames 3 to 8 show people lining the street outside the Colonial Mutual Life building in Customhouse Quay. Frames 10 and 11 show people watching from the doorway of a building. Unless otherwise stated, all persons are unidentified. Photographs taken by Ans Westra.
Source of descriptive information - Notes written by Westra, accompanying the corresponding proof sheet
Quantity: 4 b&w original negative(s) 120 strips containing 12 images.
Physical Description: Cellulose acetate roll film


The apparent heat of proton ionization, l\.H', for phenolphthalein in aqueous solutions containing 6 per cent ethanol by weight was determined by two methods, (a) the conventional spectrophotometric method in which apparent dissociation constants are obtained as a function of temperature and (b) the novel tbermochromic method. The reasonably good agreement between the results of the two methods establishes the latter as a powerful and unique tool for obtaining l\.H' values of weak acids.


An orthonormal set of irreducible fifth-rank tensors having the required permutation symmetry is constructed. Various problems not encountered in the analogous problem for tensors of ranks two, three, four and six are discussed.


Taking Malus sievers in Gongliu county as experimental materials,the distribution area of Malus sievers were calculated by Googleearth10 polygon tool,the hazard situation of Agrilus mali Matsumura on Malussievers were researched by sampling methods.The results showed that the total distribution area of Malus sieversi was 1 696.8hm2 that less than 403.2hm2 in 2000,whereas the hazard area of Agrilus mali Matsumura weighed against the distribution area of Malus sieversi.Description quarantine pests on Agrilus mali Matsumura harm was more common.The degree of harm the hazard rating of Agrilus mali Matsumura to Malussieversimostly lied between class I and class II and rarely reached class III.If do not strengthen the appropriate protective measures would continuing less within Gongliu Malus sieversi where the western region of the Tianshan mountains.


Occultation study of star forming regions, W.-P. Chen the collapse of a magnetized cloud, Z.-H. Chiueh structure and star formation in interacting galaxies, D. Elmegreen observations of protoplanetary disks in millimeter-wave continuum and molecular line emission, M. Hayashi formation of massive stars, P. Ho molecular clouds in the galactic center, P. Ho study of the Herbig-Hare objects, J.-Y. Hu formation of first generation stars in the galaxy, D. Lin formation of planetary systems, D. Lin research of molecular clouds and star formation in China, C.-P. Liu present status and future development of optical/IR observations in China, Z.-Y. Qiao on the theory of large-scale star formation, G.-X. Song present status and future development of radio astronomy in China, Z.-C. Xu early evolution of planet-forming disks, Y. Chi.


The work presented here attempts to show the advantages of relating design tools and methods that impact on improvement methodology and outcome of product design, in this case eco-design and the mechanical analysis are related in order to optimize the design to generate a lower environmental impact without loss of functional performance. The methodology proposes a market survey to select the objects to analyze, in which observe the environmental impact analysis with a specific tool so the ranges of optimal values in production, use and disposal of values and objectives and as the use of eco-design strategies are set. At the same time, a mechanical study using reverse engineering, loads and stress analysis, by means of finite elements that just results in a number of conditions and values to be taken into account in future design. Once the research and analysis raises the design stage in which proposals are made, those are analyzed using the same tools, in terms of environmental impact and structural strength, to establish more robust design from a series of alternative proposals according to predetermined design criteria. This work aims to link the findings of both analysis so as to enable optimum results and compatible design specifications and thus show the current need to develop hybrid methods that relate to the different techniques and tools.


Objective: Compare the effects of 2 molecules as induction treatment in renal transplantation (RT): polyclonal antibodies (rATG or thymoglobulin) versus a monoclonal antibody antagonist of interleukin 2 receptors (basiliximub) in terms of occurrence of episodes of rejection, delayed graft function, graft loss, and the occurrence of infectious and neoplastic complications.
Patients and methods: A retrospective study involving 191 patients transplanted from 2007 to 2016 with a minimum follow-up of 3 months at department of nephrology, dialysis and transplantation Sahloul Sousse Tunisia. The induction treatment consists of the administration of a monoclonal antibody for 67 patients group 1 (G1) and polyclonal antibodies (anti-thymocyte anti-thymocyte globulin or thymoglobulin) for 124 patients group 2 (G2). In maintenance, patients were treated with ciclosporin or tacrolimus combined with MMF and corticosteroids or MMF alone with corticosteroids.
Results: We included 191 transplant patients with mean age of 33.13 ± 13.04 years. The occurrence of episodes of rejection was more frequent in patients treated with rATG (21.77% in G2 versus 14.92% in G1) but without significant difference (p =0.253). The delay of occurrence of rejection was shorter in the G1. The uni-varied study showed that the occurrence of pneumopathies (p=0.005, OR=6.626, IC [1.503-29.20]), urinary tract infections (p=0.020, OR=2.044, CI [1.115-3.748]), cystitis (p=0.038, OR=1.918, CI [1.032-3.564]), CMV infections (p=0.04, OR=2.567, CI [0.996-6.615]) and digestive infections (p=0.035, OR=4.472, CI [0.991-20.186]) are significantly observed with rATG treatment. In multi-variate analysis only pneumopathies (p=0.014, CI [0.034-0.681]) and urinary tract infections (p=0.04, CI [0.277- 0.969]) were significantly frequent with ATG treatment. Neoplastic complications occurred exclusively in G2. We found no significant difference for delayed graft function and graft loss in both groups.


Objective: The health or livelihood paradox has become a significant issue due to the adverse effects of COVID-19 disease on the lives of millions of people in the world. In this study, we aimed to investigate the economic impacts resulting from the pandemic on Iranian households and their coping strategies and resilience. Methods: We recruited Iranian people > 18 years of age to complete a cross-sectional online survey from May 1 to June 20, 2020 (670 participants). It dealt with socio-economic and demographic features, exposure and death due to COVID-19, businesses influenced by COVID-19, household economic status after the pandemic, and coping and resilience strategies. Results: The most applied financial coping strategies were receiving loans or credits, decreasing household consumption, and selling assets and livelihoods, respectively. Half of households had already lost their income due to COVID-19-related job losses or its direct costs. Normalization of the economic situation would take more than 2 years for 8% of these households. Conclusions: The current study showed that COVID-19 economic effects could be severe and irreversible for vulnerable households. The support of policymakers, financial services providers, and private sector companies is critical in building financial resilience through the crisis and beyond.


In recent years, the applied engineering solutions in small engines have been extended down to 50 ㏄ displacement engines to satisfy the more stringent emission regulation and increasing customer demands. The existing small engines, such as air-cooled 2 stroke or 4 stroke engines with carburetor system, have to enhance their mixture preparation and also have to call for the implementation of enhanced engine technologies into small engine category, which is as well known for automotive applications. In this paper, water-cooled 4 stroke 50 ㏄ small engine with electronic control fuel injection system were developed to enhance fuel economy and to meet EURO Ⅲ emission regulations. The engine power of 4 stroke with EMS was equivalent to 2 storke engines while the maximum torque increased due to extended engine speed. In the CVS 40 mode test, more than 50% enhancement of fuel consumption rate compared to carburetor system was obtained with lower emission level due to accurate closed loop air fuel ratio control.


trans-2,3-Dimethyl-1-tri-tert-butylsilyl-1-triisopropylsilylsilirane (1) has been prepared in 98% yield by the treatment of (tBu3Si)(iPr3Si)SiBr2 with activated magnesium in the presence of trans-2...


The Weighted Region Problem is defined as the problem of finding a cost-optimal path in a weighted planar polygonal subdivision. Searching for paths on a grid representation of the scene is fast and easy to implement. However, grid representations do not capture the exact geometry of the scene. Hence, grid paths can be inaccurate or might not even exist at all. Methods that work on an exact representation of the scene can approximate an optimal path up to an arbitrarily small -error. However, these methods are computationally inefficient and thus not well-suited for real-time applications. In this paper, we analyze the quality of optimal paths on a 8-neighbor-grid. We prove that the costs of such a path in a scene with weighted regions can be arbitrarily high in the general case. If all regions are aligned with the grid, we prove that the costs are at


Despite the common notion that diuresis following alcohol exposure persists as a result of suppressed vasopressin (VP) release from the brain, we previously have shown that any suppression of plasma VP (pVP) is transient and its level returns to baseline even when blood alcohol remains significantly elevated. In this study we hypothesized that the persistent diuresis after alcohol dosing is not due to an inability of VP neurons to respond and the peptide released from the brain. Thus, we compared the response of VP neurons to an acute osmotic challenge in adult male Sprague Dawley rats that received either water or ethanol (40% v/v) at 1% BW i.g. for 5 days. On the next day, rats were given an i.v. 5% NaCl ramp at 10μl/100g/min. Blood was sampled every 20 min for determination of a plasma Na ‐ pVP dose response for 80 min, followed by rat brain harvest to determine cFos immunoreactivity in the supraoptic neurons. There was no difference in resting pVP between the two groups of rats. Alcohol rats were able to mount a full VP dose‐response and expressed cFos appropriately to the hypertonic challenge, suggesting that their brains retained the ability to detect and respond to the stimuli. The results do not suggest a suppressed VP secretion from the brain. Rather, the persistent diuresis that accompanies acute alcohol intake reflects primarily a decrease in kidney responsiveness to VP as previously shown.


Populist political parties have become a key feature of the European political landscape. In addition to claiming to be identified with the people, many of these parties are characterized by exclusionary narratives which centre on groups such as immigrants and religious minorities, a feature considered by many analysts as specific to right-wing populism. Left-wing populism is frequently defined as sharing right-wing populism's identification with the people and its anti-elitism but not its attachment to exclusionary narratives. This study joins other recent work in challenging that assumption, providing evidence for the contention that anti-elitism is also a form of excluding populist communication. Using Van Dijk's methodological approach to the analysis of the discursive positioning of 'Us/Them' and elements of Burke's dramatistic pentad, this article examines the party and electoral communication of Podemos, the self-described, left-wing populist Spanish political party, from its foundation in January 2014 up until the close of the European Union parliamentary election campaign in May 2014. The study shows that an exclusionary narrative was integral to Podemos' campaign communication in that a group of people identified as the caste (la casta) constituted the stigmatized out-group in contraposition to the in-group of the 'people' which included immigrants and the leaders of Podemos. This suggests that populist parties or politicians of all ideological stripes may be characterized by exclusionary and stigmatizing narratives.


Akshata M. Kulkarni. Transdermal drug delivery systems are becoming more popular in the field of modern pharmaceutics.The objective of this study is to determine the permeation of Pregabalin from transdermal patch into microcirculation of skin. Matrix type transdermal drug delivery system (TDDS) of Pregabalin was prepared by the solvent evaporation technique. Several batches were prepared by using combination of HPMC E-15 and Eudragit RS-100 different ratios. Propylene glycol was used as plasticizer and DMSO was incorporated as a permeation enhancer. Formulated transdermal patches were characterized for their physicochemical parameters like thickness, weight variation, folding endurance, percentage moisture uptake and drug content uniformity.The in-vitro permeation studies were performed using Franz diffusion cell. Patches were evaluated for their ex-vivo skin permeation studies. The possible drug polymer interactions were studied by FTIR.Formulation F-9 containing HPMC E-15 and Eudragit RS100 in the ratio of 200:600mg, propylene glycol 30w/v and DMSO 30%w/v was found to be the most optimum formulation and also found to exhibit maximum invitro %drug release for about 11.2 hrs. Result of evaluation studies showed that Pregabalin can be administered as a controlled drug delivery system to reduce frequency of drug administration.


Web-based case reporting systems which house questionnaires on a secure web site allow investigators from multiple sites to enter interview data directly into the outbreak database. NetEpi Case Manager is an open source software tool designed to assist with epidemiological investigations, analyses, and other aspects of public health practice. Between April and June 2005, Victoria reported an increase in the number of cases of Salmonella enterica ser Hvittingfoss (S. Hvittingfoss), with cases also detected in New South Wales, the Northern Territory, the Australian Capital Territory, Western Australia and southern Queensland. S. Hvittingfoss is a serovar often isolated from human, animal and environmental sources in northern Queensland, but is rarely identified in other parts of Australia. OzFoodNet used NetEpi to investigate this outbreak on behalf of the Communicable Diseases Network Australia. (non-author abstract)


A physical-enhanced secure wavelength division multiplexing chaos communication scheme in virtue of the chaos synchronization of two multimode semiconductor lasers (MSLs) is introduced. In this scheme, the messages are divided into a set of blocks, and these blocks are transmitted by different modes with different wavelengths, according to a pre-negotiated pattern. The numerical results indicate that the proposed scheme affords multiple simultaneous bidirectional message transmissions, and the security can be greatly enhanced. The proposed scheme provides a new way to implement high speed multichannel chaos communication with high security.


See article by Wilson et al. [9] (pages 601 –607) in this attenuated by pretreatment with L-arginine or the NO issue. donor NOR-3. These observations suggest a tonic vasoconstrictor activity dynamically opposed by NO, with the net vasomotor effect resulting from the balance of the two


Hermann Kopp, who was elected a Foreign Member of the Royal Society in 1888, and who died in Heidelberg on February 20, 1892, was born on October 30, 1817, at Hanau, where his father, Johann Heinrich Kopp, practised with some distinction as a physician.


Stress from material removal processes are compared by observation of the Twyman effect. Stress scales with the abrasive size used during mechanical removal processes, and is reduced by chemical removal processes. SSD was also measured.


Phyllanthus niruri is a herb used as a traditional medicine for treatments of jaundice, asthma, hepatitis and malaria. The present study was designed to determine the phytochemical constituents, antioxidant activity and antimicrobial analysis from ethanol and acetone extracts of the plant. Qualitative phytochemical analysis revealed the presence of cardiac glycosides, flavonoids, glycosides, polysterols, phenols, tannins, diterpenes and partial presence of alkaloids and carbohydrates. Antioxidant properties were evaluated by accessing DPPH radical scavenging effect (IC50= 66%) for acetone extract and (IC50= 56%) for ethanol extract, metal chelating activity and assaying the reducing power (FRAP) by following standard protocol. Phenol and flavonoid content of the extracts were measured by Folin ciocalteu and Alcl3 assays. The antimicrobial activity of the extract were tested against the isolates viz., Bacillus sp., Pseudomonas sp., Escherichia coli, Staphylococcus sp. and Lactobacillus sp., which were both used as wild and mutated strain for the study. These organisms were isolated from poultry feeds that are divided into four stages of the feed (pre-starter, starter, stalk and finisher) by opting disc diffusion method. The wild strain showed (0.2 mm) activity and mutated strain showed (0.3mm) in ethanolic extract, while the wild strain showed (0.3 mm) and mutated strain showed (0.2 mm) in acetone extract. Chloramphenicol was kept as a standard. The constituent components were separated in HPLC using a solvent system developed with the aid of TLC. The results of the study support the ethano-medical uses of P. niruri and P. niruri as antimicrobial agent.


PURPOSE: To connect a rotary cutting tool at a high speed and a motor-driven driver to each other in a driving manner by using spindle units changeable by each other as a tool holder. CONSTITUTION: High speed cutting is achieved with a machine tool provided with a small diameter bearing 33 which is immediately usable without using any tool holder by directly fitting and presetting a cutting tool 29 to a spindle 31 of a spindle unit 23. The spindle unit 23 is small similar to the tool holder, and preferably easily changeable by a conventional tool changing device. Since the tool holder is dispensed with, the conventional bearing is maintained small, no excessive heat to damage the bearing is generated, and the bearing can be operated at high speed of, for example, 20,000 to 40,000 rpm.


High-precision ultrasonic transmission phase delay is the key technology in phased array ultrasonic beams.On the basis of field programmable gate array(FPGA),the ultrasonic phased array system,including the phase delay algorithm and the module of the phase delay control,was designed.The algorithm of linear phased arrays was analyzed and validated.And with the waveform excitation,the coarse transmission phase delay based on the system clock is 15 ns;the fine phase delay based on the digital phase can achieve 0.35°phase resolution,which equals 3.75 ns time resolution at a 250 kHz transmission frequency.


This paper puts forth an indictators system to measure the prosperity of a nation. Throughthe analysis of the population and prosperity of the ethnic groups in China, the paper holds that the keyof the prosperity of a nation is the coordinative development of population, education and economy. Insuch a perspective, the paper znalyzes the achievements, problems and Prospects of population development and national prosperity in Tibet.


In order to change the problem of data redundancy in a genetic algorithm, this paper proposes a computer mathematical model based on the combination of an improved genetic algorithm and mobile computing. Combined with the least square method, MATLAB software is used to solve the equations, determine the range of parameters, and solve the estimation parameter range and identification problems. The improved genetic algorithm combined with mobile computing and least square method to establish a mathematical model greatly increased the individual search space and increased the operation rate of 90% compared to the basic genetic algorithm or mobile computing. The results show that the improved genetic algorithm and mobile computing have a certain ability to identify the optimal solution and greatly improve the work efficiency.


The purpose of this study is to provide effective basic data necessary for marketing strategy of HMR products by identifying the effect of HMR selection attributes on customer satisfaction according to family Composition. To this end, the research subjects conducted a survey with employees dispatched to 100 of 140 HOMEPLUS nationwide and surveyed customers who purchased HMR products from stores for about 60 days from July 1, 2018 to August 30, 2018. The data collected were analyzed for statistical significance using SPSS 21.0 for windows, and the hypothesis was verified based on the results processed. Research shows that the four factors, quality, price, convenience and variety, which are the sub-factors of HMR selection attributes, were not different according to family composition, the quality, price, and variety among the sub-factors of HMR selection attributes affected customer satisfaction, but the convenience factors did not affect customer satisfaction. The purpose of this study was to identify the effect of HMR selection attributes on customer satisfaction and to compare the differences according to the general characteristics of survey subjects, The present invention has been made in view of the above problems. ■ keyword :∣HMR∣Family Composition∣Selection Attributes∣Customer Satisfaction∣ 접수일자 : 2019년 05월 02일 수정일자 : 2019년 05월 13일 심사완료일 : 2019년 05월 13일 교신저자 : 김동수, e-mail : email@example.com 가족구성에 따른 HMR 선택속성이 고객만족에 미치는 영향 603


Author(s): Renstrom, T; Nyhus, HT; Utsunomiya, H; Schwengner, R; Goriely, S; Larsen, AC; Filipescu, DM; Gheorghe, I; Bernstein, LA; Bleuel, DL; Glodariu, T; Gorgen, A; Guttormsen, M; Hagen, TW; Kheswa, BV; Lui, YW; Negi, D; Ruud, IE; Shima, T; Siem, S; Takahisa, K; Tesileanu, O; Tornyi, TG; Tveten, GM; Wiedeking, M | Abstract: © 2016 American Physical Society. The γ-ray strength functions and level densities of Ge73,74 have been extracted up to the neutron-separation energy Sn from particle-γ coincidence data using the Oslo method. Moreover, the γ-ray strength function of Ge74 above Sn has been determined from photoneutron measurements; hence these two experiments cover the range of Eγ≈1-13 MeV for Ge74. The obtained data show that both Ge73,74 display an increase in strength at low γ energies. The experimental γ-ray strength functions are compared with M1 strength functions deduced from average B(M1) values calculated within the shell model for a large number of transitions. The observed low-energy enhancements in Ge73,74 are adopted in the calculations of the Ge72,73(n,γ) cross sections, where there are no direct experimental data. Calculated reaction rates for more neutron-rich germanium isotopes are shown to be strongly dependent on the presence of the low-energy enhancement.


We investigated the cross-talk in 6-core erbium doped amplifiers. Results indicate that the amplifier has lower cross-talk when the fiber bending radius >30 mm. The bending induced pump distribution nonuniformity can be reduced by randomly-twisting the fiber.


Critical infrastructures (CIs) are of a dual character: they are a protection good that can be adversely affected by a threat, but at the same time, some infrastructure categories are dangerous in their own right. Because it integrates collaboration and decision-making on how space should be used, spatial planning is an important process in development of CI. Risk management utilizing spatial planning includes analysis and management tools that have a spatial and place-based context. In Germany, CI deserves protection as laid down in the Federal Regional Planning Act. This research paper starts from the hypothesis that regional planning is obligated to take the physical component of CI and its susceptibility against various threats into account. However, the administrative boundaries that define a region in this context is not the appropriate level of analysis for assessing the systemic criticality of CI which is up to territorial levels that consider an entire infrastructure network and to individual project approval procedures. The paper discusses the role of regional planning for the protection of CI by the example of the Region of Cologne, Germany. This research was collaborative in nature carried out between a scientific partner and the Region of Cologne that served as a so-called model region for "co-production of knowledge". The role of science in this context is problematic because science cannot give a proof of normative aspects like the intended level of acceptable risk or the importance of the protection of CI. Science in this context is inconclusive. Thus, there was a need to involve all those experts of the regional administration that are legally responsible or involved in the assessment of risks and management of land. Throughout the project, this included representatives from the divisions of regional planning, natural protection, water management, immission control and crisis management. The entire team of researchers and practitioners came to an agreement on the various normative decisions, for example, concerning the research approach or the definition of susceptibility indicators. This collaborative approach, which is principally applicable in other regions in Germany as well, guarantees for applicability of planning decisions on the ground. Finally, using results from a GIS-based risk assessment demonstrated how regional spatial planning takes CI into account. The assessment results will be used by the administration of the Region of Cologne for the Environmental Report to be prepared for the new regional plan.


This paper demonstrates the potential of a qualitative empirical research method [Ganzheitliche Bewaltigung von Komplexitat (GABEK®)] for systemic sustainability research. We interpret systemic corporate sustainability as a research programme that views the company and its environment as an ongoing process of social construction. Furthermore, we argue that the mental models of relevant actors are crucial within the process of social construction. We then present GABEK® as a unique method for qualitative empirical content analysis and highlight that GABEK® can contribute substantially to systemic sustainability research because it holds the potential to unearth and analyze the mental models of diverse actors with the scrutiny of empirical research. We illustrate this potential with a case study of a major German company's sustainability management (BASF AG), and we outline avenues for future research for an empirically oriented approach to systemic sustainability research.


Abstract The constraints of minute reactant amounts and the impossibility to remove any undesired surface‐bound products during monolayer functionalization of a surface necessitate the selection of efficient, modular and orthogonal reactions that lead to quantitative conversions. Herein, we explore the character of sulfur–fluoride exchange (SuFEx) reactions on a surface, and explore the applicability for quantitative and orthogonal surface functionalization. To this end, we demonstrate the use of ethenesulfonyl fluoride (ESF) as an efficient SuFEx linker for creating "SuFEx‐able" monolayer surfaces, enabling three distinct approaches to utilize SuFEx chemistry on a surface. The first approach relies on a di‐SuFEx loading allowing dual functionalization with a nucleophile, while the two latter approaches focus on dual (CuAAC–SuFEx/SPOCQ–SuFEx) click platforms. The resultant strategies allow facile attachment of two different substrates sequentially on the same platform. Along the way we also demonstrate the Michael addition of ethenesulfonyl fluoride to be a quantitative surface‐bound reaction, indicating significant promise in materials science for this reaction.


At the present stage of development of society, the problems of the quality of life of people with disabilities and disabilities are especially relevant. The policy of modern Russia has a course towards reducing isolation and segregation of this category of citizens. Education for a person is an important condition for a full life and the ability to fulfi ll their educational needs. The state has formulated a clear idea of the mechanism for creating a school for all students. Inclusion makes it possible for each student to obtain knowledge in the volume necessary for him, taking into account his physical and mental state. Assistive technologies are aimed at supporting and improving the functionality of students with disabilities and disabilities. At the present stage of the development of inclusive education, the needs for assistive technologies are largely unmet.


This essay examines the concept of fate, exploring the causal-normative constraint problem in the existential phenomenology of humanity in A Dream of Red Mansions. It studies the structure, content, and origin of the consciousness and experience of fate, as it is illustrated in the phenomenology in the novel, exploring the causal and normative challenges that fate poses to the reality, value, authenticity, happiness, and freedom of a person. Doing so, the essay also demonstrates both the difference and affinity between the Chinese concept of fate and Hindu concept of karma, as well as existentialist (Heideggeran) concepts of 'thrownness' and 'existentiality.'


Helmholtz's theory of space had significant impact on Schlick's early 'critical realist' point of view. However, it will be argued in this paper that Schlick's appropriation of Helmholtz's ideas eventually lead to a rather radical transformation of the original Helmholtzian position.


The 11 coastal provinces in China are experimental fields of the development of marine economy which requires marine science and technology talents. As marine industry cluster expands its scale, the distribution of marine science and technology talents are found to be unbalanced among regions. This paper endeavors to make a comprehensive evaluation of the marine science and technology talents in the coastal 11 provinces by establishing a multi - dimensional evaluation system which features marine industry as the dominant industry while including other elements such as education, scientific research, economic and living environment. The evaluation targets are divided into three levels—strong, medium and weak—according to their respective agglomeration. From the perspective of geographic advantages, we put forward a complementary interaction strategy for the strong and weak agglomeration areas, hoping to provide accurate reference to local governments' scientific policy formation.


Purpose

The high calculation effort for accurate material loss simulation prevents its observation in most magnetic devices. This paper aims at reducing this effort for time periodic applications and so for the steady state of such devices.

Design/methodology/approach

The vectorized Jiles-Atherton hysteresis model is chosen for the accurate material losses calculation. It is transformed in the frequency domain and coupled with a harmonic balanced finite element solver. The beneficial Jacobian matrix of the material model in the frequency domain is assembled based on Fourier transforms of the Jacobian matrix in the time domain. A three-phase transformer is simulated to verify this method and to examine the multi-harmonic coupling.

Findings

A fast method to calculate the linearization of non-trivial material models in the frequency domain is shown. The inter-harmonic coupling is moderate, and so, a separated harmonic balanced solver is favored. The additional calculation effort compared to a saturation material model without losses is low. The overall calculation time is much lower than a time-dependent simulation.

Research limitations/implications

A moderate working point is chosen, so highly saturated materials may lead to a worse coupling. A single material model is evaluated. Researchers are encouraged to evaluate the suggested method on different material models. Frequency domain approaches should be in favor for all kinds of periodic steady-state applications.

Practical implications

Because of the reduced calculation effort, the simulation of accurate material losses becomes reasonable. This leads to a more accurate development of magnetic devices.

Originality/value

This paper proposes a new efficient method to calculate complex material models like the Jiles-Atherton hysteresis and their Jacobian matrices in the frequency domain.


oh.LF paper deals with the stochastic sample or almost sure stability of the modes at rest in general coupled nonlinear oscillatory systems sub.+cted to external rand o m e x c i t a t i o n . B y u s i n g t h e s m a l l perturbation method and Lyaplnov ,finction method, sujjicient conditions .&r stability o,f the rest modes are established and applied to examine the stability o.fpitching vibration in a nonlinear absorber sub.bcted to a random vertical support excitation.


Vitreoretinal surgery is one of the most difficult surgical operations, even for experienced surgeons. Thus, a master-slave eye surgical robot has been developed to assist the surgeon in safely performing vitreoretinal surgeries; however, in the master-slave control, the robotic positioning accuracy depends on the surgeon's coordination skills. This paper proposes a new method of autonomous robotic positioning using the shadow of the surgical instrument. First, the microscope image is segmented into three regions—namely, a micropipette, its shadow, and the eye ground—using a Gaussian mixture model (GMM). The tips of the micropipette and its shadow are then extracted from the contour lines of the segmented regions. The micropipette is then autonomously moved down to the simulated eye ground until the distance between the tips of micropipette and its shadow in the microscopic image reaches a predefined threshold. To handle possible occlusions, the tip of the shadow is estimated using a Kalman filter. Experiments to evaluate the robotic positioning accuracy in the vertical direction were performed. The results show that the autonomous positioning using the Kalman filter enhanced the accuracy of robotic positioning.


Two field experiments were conducted during successive summer seasons of 2007 and 2008 at Sakha Agricultural Research Station to investigate the efficacy of some weed control treatments i.e. butralin, Prometryne and fulazifop-p-butyle, whether alone or in combination, or plus one hand hoeing in addition to the hand hoeing twice for controlling annual weeds and their effects on some growth characters, seed yield and its components of sunflower. Results indicated that the herbicides, whether in combination, or plus one hand hoeing decreased dry weight of total weeds during the two seasons. The treatments ( butralin and prometryne) plus fluazifop-p-butyl reduced the dry weight of total weeds by 83.5 and 84.1 %, respectively in the first season and 86.2 and 88.7 %, respectively in the second season while, the herbicides plus one hand hoeing reduced the dry weight of total weeds 84.1, 87.7 and 85.5 %, respectively in the first season and, 93.3, 95.8 and 94.4 % respectively in the second season as compared to the control at 65 days from sowing. Hand hoeing twice was reduced total weeds only by 81.1 and 91.7 %. Therefore, it can be used herbicides, whether combined between in, or plus one hand hoeing for the control of most annual weeds.
Results revealed that all studied herbicides plus one hand hoeing  or in combination significantly increased growth characters of sunflower i.e. plant height, stem diameter and dry weight/plant during the growth stage and at harvest. (Butralin, prometryne and fluzazifop-p-butyle) plus one hand hoeing increased seed yield/fed by about 47.91, 48.62 and 44.84 % and, by about 45.45, 45.86 and 42.21%, during both growing seasons, respectively as compared to the control t. Data also cleared that all herbicide treatments slightly decreased chlorophyll a, b and total chlorophyll but did not adversely affect oil content of sunflower seeds.
These results indicated that under heavy invested soil with annual weeds, it is possible to apply herbicides i.e. butralin at 2.5 l/fed, prometryne at 1.0 l/fed, and fluazifop-p-butyl at 1.0 l/fed followed by (one hand hoeing) after 30 days from sowing or combined between in). Also, the highest net return was obtained by herbicides plus one hand hoeing and hand hoeing twice. These practices gave the height reduction in annual weeds and increased sunflower yield and its components. Thus, these herbicidal treatments can replace hand hoeing for the control of annual weeds in sunflower crop.


Hepatic steatosis has been associated with fibrosis, but it is unknown whether the latter is independent of the etiology of fat infiltration. We analyzed the relationship between clinical characteristics, insulin resistance (HOMA‐R) and histological parameters in 132 patients with "viral" steatosis caused by genotype 3 chronic hepatitis C (CHC‐3) and 132 patients with "metabolic" steatosis caused by nonalcoholic fatty liver disease (NAFLD), matched by age, BMI, and degree of liver fat accumulation. Tests of liver function were comparable in the two study populations. The prevalence of features of insulin resistance was higher in NAFLD, as was HOMA‐R (P = .008). Logistic regression analysis confirmed that steatosis was associated with a high viral load and low serum cholesterol in CHC‐3, and with high aminotransferase, glucose, ferritin and hypertriglyceridemia in NAFLD. At univariate analysis, advanced fibrosis was associated with steatosis in NAFLD, but not in CHC‐3. Other parameters related to fibrosis severity were HOMA‐R and a low platelet count in CHC‐3, and high aminotransferases, HOMA‐R, ferritin and low HDL‐cholesterol in NAFLD. On multivariate analysis, only low platelet count (OR = 0.78; 95% CI, 0.67‐0.92) and HOMA‐R (OR = 2.98; 1.13‐7.89) were independent predictors of advanced fibrosis in CHC‐3. In NAFLD, severe fibrosis was predicted by fat grading (OR = 3.03; 1.41‐6.53), ferritin (OR = 1.13; 1.03‐1.25) and HOMA‐R (OR = 1.16; 1.02‐1.31). In conclusion, insulin resistance is an independent predictor of advanced fibrosis in both NAFLD and CHC‐3, but the extent of steatosis contributes to advanced disease only in NAFLD. Virus‐induced hepatic steatosis as seen in CHC‐3 does not contribute significantly to liver fibrosis. (HEPATOLOGY 2006;44:1648–1655.)


Research shows that the world's children spend more than six hours per day on media use (Leggett, 2013). If consumed in an appropriate fashion, the media can enrich children's lives, although excessive use of the media from an early age and exposure to violent and other inappropriate content can adversely affect children's development, thinking, attitudes and behavior. Many research studies have revealed that even before they start school, children spend several thousand hours on media use, during which they are exposed to tens of thousands of instances of violent content and hundreds of thousands of advertisements (Strasburger, 2009, Trend, 2007; Story, French, 2004). Precisely for this reason, countries such as Sweden have long ago recognized the importance of introducing media education for children as early as in preschool. A unique characteristic of such education is that it emphasizes the role of parents, whose mediation can significantly affect the program's effectiveness, although there is a general lack of comprehensive research examining the attitudes of parents about the media education of children. In Croatia, children start to learn about the media only in the first grade of primary school, as part of Croatian language courses. Until then, it is up to the parents to teach their children about media content, a process that should start from the very beginning. However, parents themselves often lack sufficient knowledge about the media and their influence on children. Since many parents believe


Amerasinghe's book presents a comprehensive research of one of the most important rules of international responsibility: the rule of local remedies. This undisputed rule is just as topical today as it was at the beginning of the century. At the outset of the book the author presents his aim: "While it is not the existence or validity of the rule that needs to be supported, there are many aspects and applications of it that need to be clarified''. It seems that the author succeeded in his task to thoroughly survey the foundations of the rule and to analyse its applications (and limitations) in various fields of international law today. We have no doubt that this comprehensive book will be useful to many international lawyers and scholars dealing with international claims. One of the most interesting questions about the scope of the rule of local remedies is dealt with in the appendix "International Organizations and Local or Internal Remedies" (pp. 367-384). The law of international organizations' responsibiKty is still in a process of change and the application of the rule in this sphere is still debated by eminent scholars. The author has addressed the question whether "where the international organization is the respondent in a case involving the protection of a national... [and] where the. . . organization does provide internal means of settling disputes between such persons and itself, they have an obligation to exhaust such remedies before their national


Home‐based resistance exercise is commonly used for individuals who might not have access or the ability to use traditional resistance exercise. However, the extent to which home‐based resistance exercise can improve both strength and functional ability has not been investigated in healthy older individuals using a systematic analysis. The current article systematically reviewed the effectiveness of home‐based resistance exercise on strength and functional ability. Search engines included Academic Search Premier, CINAHL, PubMed, PsycINFO, MEDLINE, SPORTDiscus and Web of Science. A total of 649 articles were found using the key words "home‐based" and "strength" and "older" or "elderly", with eight articles meeting the final criteria. The average age of the participants was 76 years, with the average duration of exercise training ranging from 8 weeks to 120 weeks. Of the eight studies, a significant increase in knee extension strength was found in five studies. Functional ability significantly improved in seven of the eight studies, with the average decrease in Timed Up & Go test being −0.8 ± 0.5 s. Three studies included greater amounts of supervised visits compared with the other five studies (∼51% vs ∼7%). The more supervised studies had significant increases in strength and functional ability. Overall, home‐based resistance exercise can improve both strength and functional ability, but the improvements are generally small. The intensity of the exercises might not progress sufficiently enough to produce large improvements in strength as a result of less supervision or a lack of motivation to increase the intensity further. Geriatr Gerontol Int 2014; 14: 750–757.


Large cyclo-converter drives using either synchronous or induction machines are found in a number of low speed high torque applications: these include steel mills, gearless cement mills, mine winders and ice breakers.
The cyclo-converter output frequency is synthesised from portions of the high voltage supply system. At low frequencies this produces an output current waveform which is reasonably sinusoidal, as the frequency increases the waveform become more distorted. There is concern for the level of current harmonics produced by the cyclo-converter in both the motor windings and the supply system. The waveform distortion is mainly due to the switching action of the cyclo-converter, this is modified by the effects of interbridge changeover delay, commutation overlap, the supply and decoupling reactances.
Industrial drives are required to conform to the Electricity Council's regulations on input current harmonics and voltage waveform distortion. In marine drives the main generators feed the ship propulsion system and the ship's auxiliary supplies. The level of interference produced by the converter input line current on the supply network is of particular concern. High levels of voltage distortion may cause malfunction of the auxiliary equipment and produce large torque pulsations in the supply alternator.
The cyclo-converter generates unwanted harmonics in the output current waveforms, these are responsible for torque pulsations on the motor drive. With naval marine drives the torque pulsation is of particular interest, since this level must be minimised to increase the sensitivity of detecting instruments such as passive sonar.
To date, mathematical models and computer based models have not detailed all the aspects which are responsible for the distortion to the converter input and output waveforms. This thesis seeks to address this and identify the effects on the converter performance of, the converter interbridqe delay, overlap and the supply parameters supply and decoupling reactance. Various motor models will also be examined.
The author has used the mathematical work by Pelly as a basis, and has identified the percentage errors in the level of harmonic currents which are likely to be introduced if his results are used in designing new systems.
Comparisons will be made with experimentally produced results obtained from a mine winder at the Wearmouth Colliery. Results from a lower powered cyclo-converter produced experimentally and computationally at Newcastle University will also be examined.


The Fuzzy Front End (FFE) theory, which focuses on the market decision making process and utilizes the online simulation methods to test the design ideas, it is easy to understand, convenient to control, and fit to meet the rapidly changing market demands. The FFE theory is preferred for a timely and effective conceptual design of the new product development. Combination the Fuzzy Front End theory, a Flexible Four-Terminal (F4T) principle is deduced corresponding to its metaphorical analogy to the four bar linkage mechanism. Using the F4T principle and the Fuzzy Front End theory, a new FFE frame model is established for the product innovation and design process.


most importantly, its implications for what might be termed the sociology of labor discipline; its treatment of the connection between wealth and power, and its treatment of economic democracy. Let us outline what we take to be the major criticisms of our paper. Several respondents claim that power, in the sense of the capacity to gain compliance by the privately wielded threat of imposing sanctions, is not an important part of the operation of capitalist economies. Michael Burawoy and Erik Olin Wright argue that consent and reciprocity rather than coercion and domination characterize the labor process in advanced capitalism. John Roemer, agreeing with us that both capital and labor markets are contested exchanges and that employers wield the power to sanction workers, nevertheless doubts that power in this sense exists in


In this paper, a novel OFDMA architecture based on the characteristics of the indoor visible light communication network is introduced. It is characterized by a microcell structure and frequent terminal switching. The OFDM proposed in this paper adopts DCO-OFDM modulation technology, which is determined by the consideration of the nonlinear and non-negative signal transmission characteristics of LEDs, and the SLM algorithm is also introduced to reduce PAPR. The simulation results demonstrate that the SLM algorithm can effectively reduce the PAPR of DCO-OFDM, which increases the probability that the signal in the entire system is lower than the PAPR threshold. Compared with the SLM algorithm, its CDF probability is increased by about 40%, and the SNR is also improved by 2.5 dB. The proposed OFDMA is a semi-distributed structure that is controlled by the DME to allocate subcarriers to each AP, and each has the ability to allocate subcarriers independently. Based on this architecture, an idea of dynamic subcarrier allocation is proposed, and uses the optical power received by the terminal as the SIR index to allocate different subcarriers to different SIR terminals and optimize the utilization of resources. The results of the modeling and simulation indicate that when the subcarrier allocation algorithm and method of reducing PAPR via SLM are combined, the BER of the system is significantly improved; when the SNR is 13 dB, the BER can be reduced to less than 10-6. This method can help the system reach the perfect communication target with a lower SNR, allowing the system to achieve better BER performance with less power consumption.


Phellinus formosanus sp. nov. and P. prunicola sp. nov. found growing saprotrophically on decayed stems of Schima superba and Prunus mume, respectively, in Taiwan, are described and illustrated. Cultural characters are described.


Nan Guonong is a pioneer who has been adhering to attaching importance to "human being" in e-Education.This paper interprets his humanistic thought from e-Education view,all-round development of human beings,relationship between human beings and technology.Nan Guonong's Humanistic Thought of e-Education is of great significance for the current and future development of Education Technology,which is worthy of our more attention in epistemology,practice and methodology.


The reactive programming paradigm has been proposed to simplify the development of reactive systems. It relies on programming primitives to express dependencies between data items and on runtime/middleware support for automated propagation of changes. Despite this paradigm is receiving increasing attention, defining the precise semantics and the consistency guarantees for reactive programming in distributed environments is an open research problem.
 This paper targets such problem by studying the consistency guarantees for the propagation of changes in a distributed reactive system. In particular, it introduces three propagation semantics, namely causal, glitch free, and atomic, providing different trade-offs between costs and guarantees. Furthermore, it describes how these semantics are concretely implemented in a Distributed REActice Middleware (DREAM), which exploits a distributed event-based dispatching system to propagate changes.
 We compare the performance of DREAM in a wide range of scenarios. This allows us to study the overhead introduced by the different semantics in terms of network traffic and propagation delay and to assess the efficiency of DREAM in supporting distributed reactive systems.


Graph neural networks (GNNs) have witnessed widespread adoption due to their ability to learn superior representations for graph data. While GNNs exhibit strong discriminative power, they often fall short of learning the underlying node distribution for increased robustness. To deal with this, inspired by generative adversarial networks (GANs), we investigate the problem of adversarial learning on graph neural networks, and propose a novel framework named NAGNN (i.e., Neighbor-anchoring Adversarial Graph Neural Networks) for graph representation learning, which trains not only a discriminator but also a generator that compete with each other. In particular, we propose a novel neighbor-anchoring strategy, where the generator produces samples with explicit features and neighborhood structures anchored on a reference real node, so that the discriminator can perform neighborhood aggregation on the fake samples to learn superior representation. The advantage of our neighbor-anchoring strategy can be demonstrated both theoretically and empirically. Furthermore, as a by-product, our generator can synthesize realistic-looking features, enabling potential applications such as automatic content summarization. Finally, we conduct extensive experiments on four public benchmark datasets, and achieve promising results under both quantitative and qualitative evaluations.


The present invention relates to two types of regorafenib organic acid salts as represented by formulas (I, II), that is, 2-hydroxyl esylate (isethionate salt) and ethyl sulphonate of regorafenib. The present invention also relates to two types of crystal forms of the regorafenib isethionate salt (formula I), named as crystal form A and crystal form B. The present invention also relates to two types of crystal forms of the regorafenib ethyl sulphonate (formula II), named as crystal form α and crystal form β. Also disclosed is a new crystal form of the regorafenib p-toluenesulphonic acid salt, named as crystal form N-1. Also disclosed is a preparation method of regorafenib isethionate salt crystal forms A, B, regorafenib ethyl sulphonate crystal forms α, β and regorafenib p-toluenesulphonic acid salt crystal form N-1. The disclosed regorafenib isethionate salt crystal forms A, B, regorafenib ethyl sulphonate crystal forms α, β and regorafenib p-toluenesulphonic acid salt crystal form N-1 have X-ray powder diffraction characteristic absorption peaks and differential scanning calorimetry (DSC) characteristic absorption peaks, and regorafenib isethionate salt crystal form A, regorafenib ethyl sulphonate crystal form β and regorafenib p-toluenesulphonic acid salt crystal form N-1 are stable, do not absorb moisture easily, and have good solubility.


Objective:To detect the serum TGF-β_1 in unexplained habitnal abortion(UHA) patients before and after the immunotherapy inorder to explore the function TGF-β_1 in the genesis and treatment of UHA.Methods:Applied ELISA method to detect serum TGF-β_1 before and after hypodexmic injection of the couples′ lymphocytes in 30 UHA patients and 30 healthy non-pregnancy women.Results:TGF-β_1 in UHA patients(10178.50±3258.60) has significantly reduced than that in healthy non-pregnancy women(11988.10±3423.65),(P0.025=;TGF-β_1 in 24 successful pregnancy women(12801.21±3510.97) has significantly elevated after treatment,(P0.025=;otherwise TGF-β_1 in 6 unsuccessful pregnancy women after treatment(11079.50±3227.21) has no significant changes(P0.05).Conclusion:Reduced serum TGF-β_1 is probabty related to the genesis of UHA.Immunotherapy may elevate the level of serum TGF-β_1 which call induce maternal immunotolerance and acquire successful pregnancies.


We propose a fully convolutional neural network (FCNN) model for ice concentration estimation from dual-polarized SAR images. Our network contains 5 convolutional layers. Tested in the Gulf of Saint Lawrence during freeze-up, the proposed model is demonstrated to generate improved ice concentration estimates compared to a CNNs with similar structure.


This study aims to assess the relevant aspects related to solid waste, noise and odors caused by street markets. The central question was based on fieldwork research, conducted during five events in the city of Osasco. The main objective of this study was to verify the environmental issues affecting workers, customers and residents caused by volume of waste, noise level generated by equipment whilst setting up and putting down the stalls and perception of odors generated by street markets. It was found that large volumes of waste are directly correlated to unwanted odors affecting customers and residents and the noise generated by street market hardware is violating the law by exceeding the maximum tolerance by technical standards, affecting workers and residents.


The aim of this study is to compare the efficacy and safety of ciomipramine and sertraiine in patients with premature ejaculation. The study included total 33 patients, with true premature ejaculation (PE), age ranged from 23 to 45 years old (mean: 30.5 years). The patients were randomly divided into 3 groups; 12 patients as ciomipramine group, 11 patients as sertraiine group and 10 patients as placebo group. Each patient took 1 capsule daily for the first week, then 2 daily for trie remaining 7 weeks. The efficacy of each drug was assessed With intravaginal ejaculation latency time and sexual satisfaction rate of patient and partner, and side effects of drugs were recorded. Mean intravaginal ejaculation time increased from 1.45 minutes (0.5-2•minutes) to 5.5 + 2 minutes, 5 + 2 minutes and 2.5 + 1.5 minutes in ciomipramine,- sertraiine and placebo-groups respectively. Sexual satisfaction rates of patients and partners were parallel with that intravaginal ejaculation durations. Side effect ratios were 90 % in ciomipramine group and 60 % in sertraiine group. Although the incidence of side effects with ciomipramine was significantly higher compared to that of sertraiine (p0.5). As a result sertraiine is as effective as ciomipramine in treatment of PE with minimal side effects compared to those of ciomipramine. Thus, we recommend th,af sertraiine should be the first choice in the treatment of PE.


This letter addresses the problem of navigation using only relative directional measurements (i.e., relative distances are unknown) with field of view constraints. We present a novel navigation vector field for the bearing-based visual homing problem with respect to static landmarks in 2-D and 3-D environments. Our method employs two control fields that are tangent and normal to ellipsoids having landmarks as their foci. The tangent field steers the robot to a set of points where the average of observed bearing vectors is parallel to the average of the desired bearings. The normal field uses the angle between different pairs of bearings as a proxy to adjust the robot's distance from the landmarks and to satisfy the field of view constraints. Both fields are blended together to construct an almost globally stable control law. Our method is straightforward to implement, as it requires only comparisons between average bearings, and angles of pairs of vectors. We provide simulations that demonstrate the robustness of our approach on two systems: a double integrator, and a unicycle.


The video game industry has evolved significantly, with different genres becoming popular over time, but how to visualize such information by curating data into a form that makes it easier to identify and understand the trends is quite an interesting research topic. This research focuses on producing an animation of aesthetically pleasing two-dimensional (2D) undirected graphs based on PC video game datasets. The data are further analyzed for developing a web-based application giving users the ability to control and create the animation of a graph. To make it easier to understand the animation of a graph, the changes between the displays of the previous and the following periods are set as small as possible, allowing a user to grasp the differences of the graph's structure faster. A genetic algorithm-based undirected graph drawing that minimizes both the aesthetic criteria and mental map cost are proposed in this research to tackle this problem. Furthermore, based on our experiments, we could find the best period to start with, so we do not necessarily need to start from the first period to calculate the animation result. Our experiment results proved that a smoother animation could be achieved, and information is better preserved throughout the animation.


To analyze the relationship between parenting stress and maternal child feeding styles with preschooler's body mass index.

 A total of 344 mother-child dyads from ten public kindergartens from Monterrey Nuevo Leon, Mexico; participated in the study. Mothers answered 1) The Parental Stress Scale to identified parenting stress, and) The Caregiver Feeding Style Questionnaire was used to identify the mother's feeding style. Child's weight and height were measured. Body Mass Index was obtained and classify according to World Health Organization.

 51.7 (n = 178) mothers reported high parenting stress. The authoritarian feeding style was more frequent in mothers with high parenting stress 33.1 (n = 59), while mothers with low parenting stress presented an indulgent feeding style (38.6%, n = 64). Mothers with an indulgent style had children with a high BMI. Maternal factors such as styles and preschool BMI were identified as predictors of parenting stress, variance explained 7.3%.

 High maternal parenting stress is related to authoritarian feeding style. A style has been considered a predictor of childhood overweight-obesity. It is recommended to continue studying those maternal factors that potentiate the risk of overweight-obesity in childhood, as well as interventions aimed at reducing parenting stress and the use of healthier feeding styles.

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We present abundances of Ti, Fe, and Ni as well as 10 post–iron‐peak elements in two Galactic S stars, S UMa and Stephenson 1303. Based upon the presence or absence of Tc in their spectra, S UMa is an intrinsic S star and Stephenson 1303 is an extrinsic S star. Both stars are slightly metal‐poor and at high Galactic latitude; they thus make an interesting comparison as well as a further test of current models of nucleosynthesis in low‐mass stars. In addition, the abundance ratio of heavy to light s‐process elements, [hs/ls], correlates with the metallicities of Stephenson 1303 and S UMa as expected if the 13C neutron source drives the s‐process.


The establishment project appraisal mechanism,improves designers' overall quality,arouses Designing department's enthusiasm effectively,pays great attention to strengthen in the project construction the design alteration management,carries out the implementation quota design is from vigorously the engineering design aspect active control building cost of projects essential measure.


. A retrospective study of 104 dialysis candidates with end-stage renal failure has shown this is rarely caused by pyelonephritis. A proportion of 8.7% of the patients had confirmed chronic pyelonephritis (chronic urinary tract infection). If chronic interstitial nephritis and pyelonephritis are considered as one group, this constituted 26% of the series. Most patients had glomerulonephritis (53.8%) and reached the end-stage at a younger age than patients with pyelonephritis and chronic interstitial nephritis. The progression from moderate renal failure to end-stage failure was more rapid in patients with glomerulonephritis than in those with pyelonephritis and interstitial nephritis. Working disability had not presented a major problem in this group of patients with severe renal failure.


Heart transplantation is the last method for the patients who are suffering from heart failure refractory to conventional medical treatment. Traditional contraindications of heart transplantation are irreversible pulmonary arterial hypertension, active infection, irreversible renal, hepatic dysfunction, coexisting neoplasm, psychosocial instability, substance abuse and so on. But these days, traditional contraindications have been changed because increased clinical experience allowed liberalization of patients who were previously considered contraindication. We experienced a case of successful heart transplantation in dilated cardiomyopathy patient with preoperative delirium. (Korean J Anesthesiol 2007; 53: 395~8)


Dr. Macdonald has presented a really topnotch contribution to both microbiology and pathogenesis, which represents the culmination of many years of very arduous and brilliant efforts. At the same time, he and his colleagues have added some more significant pieces of information to a pattern that has been emerging gradually from his and other laboratories for some years. Table 1 is presented here not as a new conception but merely as a means of bringing together what has been said by Dr. Macdonald and others during this conference concerning possible bacterial actions in chronic periodontitis. (I decided to use the term "chronic periodontitis" in preference to the almost universal, but nondescript, phrase "periodontal disease" after many discussions with a number of my dental colleagues. There seems to be a consensus among them that the modal form of perio-


Introduction: The general reactivity of I(III) compounds is determined by the hypervalent, weak nature of the I-R bonds and the partial positive charge localized at the iodine atom, which makes Ar-IX2 compounds highly electrophilic. Hence, typical reactions of hypervalent I(III)-compounds are substituent transfer to organic compounds or reductive coupling of these same groups (Figure 1). This reactivity has made I(III) compounds very popular reagents in organic synthesis where they are often used as electrophilic transfer reagents for late-stage modifications.[1] Examples of this versatility are the already developed trifluoromethylation, alkynylation, arylation, amination, halogenation and cyanation protocols that are efficient for of a wide variety of nonprefunctionalized substrates under quite mild conditions.[2]


The present invention provides a system and method for managing acquisition of goods using a credit card of a client in a way whereby the details of the credit card are not exposed or revealed to the supplier or the seller throughout the acquisition process. This method can bring about new users that are not buying merchandise through the internet due to their fear from credit card frauds. This method can also bring about new users that are not buying merchandise using a credit card in which the details of the credit card are exposed directly or indirectly to a supplier due to their fear from future misuse of their credit card details.


Records were kept of the catches of tsetse fly by three types of traps, the Langridge box screen, the Swynnerton awning screen, and a modification of the latter incorporating a screen skirt, in the South Busoga fly-belt, Uganda, where Glossina pallidipes Aust., G. fuscipes Newst. and G. brevipalpis Newst. are abundant. Only two specimens of G. brevipalpis , but large numbers of the other two species, were caught, by far the largest catches being obtained by the awning screen-skirt trap.


The article is a review of existing methods of plant phenotyping. The importance of the automatic registration process for accurate and precision assessment of morphological, physiological, and anatomical parameters of plants has been substantiated. Algorithms and methods for calculating the phenotypic characteristics of plants are considered. The common pipeline of plant feature extraction is identified. The review includes approaches based on the use of 2D images and approaches using 3D models of plants. The pros and cons of each approach are given. Next, the authors discuss the existing automated systems for plant feature extraction of three classes, namely, based on usage of images, images and depth maps of the object, 3D models. Such systems are used in laboratories of plant biotechnology, laboratories of commercial enterprises, and in the fields. For each phenotyping complex, the research results are described, the most important parts are identified, and the system output parameters are given.


This second edition extends and improves on the first, already an acclaimed and original treatment of statistical concepts insofar as they impact theoretical physics and form the basis of modern thermodynamics. This book illustrates through myriad examples the principles and logic used in extending the simple laws of idealized Newtonian physics and quantum physics into the real world of noise and thermal fluctuations. In response to the many helpful comments on the first edition, important features to this edition include additional figures, new problems, and worked-out solutions to some representative problems.Armed with the wit and knowledge of a new coauthor, the topics of renormalization group and Monte Carlo numerical techniques are now treated on a par with more conventional elements of statistical thermodynamics. The addition of these important subjects thus allows a coherent picture of thermal physics to emerge. This new edition incorporates important aspects of many-body theory and of phase transitions. It should better serve the contemporary student, while offering to the instructor a wider selection of topics from which to craft lectures on topics ranging from thermodynamics and random matrices to thermodynamic Green functions and critical exponents, from the propagation of sound in solids and fluids to the nature of quasiparticles in quantum liquids and in transfer matrices.


Introduction : Infectious disease is major problem in Indonesia. The right antibiotic infiltration strategy will reduce incidence rate of infection and resistance. Moreover, resistance can be overcome by increasing antibiotics action by combining it with herbs which have an active antibiotic compound such as Elephantopus scaber Linn . E. scaber is a herb that has already been carried out by research which is found to contain flavonoids, steroids and alkaloid. This research aims to examine the group of polar compound, and examine those compound combinations with amoxcillin and chloramphenicol , measure the inhibition change toward S.aureus and E. coli. Methods : : The Methanol Extract is fractionated with silence phase by using Silica Gel and motion phase by using pure ethylacetate . The interaction between herbs and antibiotics is assessed by Ameri-Ziaei Double Antibiotic Synergism Test (AZDAST) method and the assessment of inhibition is by using Kirby-Bauer method. Phytochemical test is done with formaldehyde spray, FeCL 3 , and dragendorff of thin layer of chromatography. The result was analyzed by using SPSS with the significant level of p 0,05) while on fraction 30 chloramphenicol against S. Aureus Bacteria has antagonistic interaction with ZOI values 13,6 +- 3,0 and significance (p>0,05). In the combination of amoxicilin antibiotics against S. Aureus and E. Coli obtained type of interaction is not distinguishable. Conclusion : Single herbal F27-32  has no antimicrobial activity. In fraction 27 contains alkaloid, saponins, and phenol, while fraction 28-31 contains alkaloid and phenol. Fraction 32 contains alkaloid compound. Keywords : Elephantopus scaber., Amoxicillin, Chloramphenicol , Phytochemical Test, ZOI, Combination of Antibiotics and Herb


The possibility of amplification of the coupled plasmon—the longitudinal optical phonon (LO) mode in HgTe quantum wells is theoretically considered assuming an inverted band population. We calculate the dispersion of the plasmon-LO modes taking into account the spatial dispersion of the electronic polarizability. It is shown that stimulated emission of the plasmon-LO mode is possible in the frequency range corresponding to the Reststrahlen band of GaAs both in a 6 nm wide HgTe/CdTe QW and in a 5 nm wide HgTe/Cd0.7Hg0.3Te QW grown on the (013) plane. Due to the anisotropy of the dispersion law for the plasmon-LO mode, the [03−1] direction appears to be optimal for generation.


This article reports the development of a self‐report Interpersonal Communication Competence Scale (ICCS) that taps 10 dimensions of competence: self‐disclosure, empathy, social relaxation, assertiveness, interaction management, altercentrism, expressiveness, supportiveness, immediacy, and environmental control. First, we created the ICCS, reducing the number of items from an original 60 to 10. Then we established concurrent validity of the scale by looking at the ICCS's relationship to cognitive and communication flexibility.


Zeng Gong was one of the famous EIGHT GREAT WRITERS OF TANG DYNASTY AND SONG DYNASTY.Besides his great achievement in literature,his economic theory was also rich,which involved saving,commerce,social relief and agriculture.He inherited Chinese traditional Confucianist economic theory,and meanwhile had characteristic of his times.


Smart windows are recognized as a promising technology to reduce building energy consumption, however a major challenge in electrochromic materials with application directed to smart windows is to ensure their durability and stability for at least 20 years [1]. Electrochromic materials have gained considerable interest during de last decades [1] because of their interesting properties that make them capable of a reversible change evocation in their optical properties through an applied voltage pulse, due to the insertion and extraction of charges in the material [2].


This paper discusses an analytical dynamic traffic assignment (DTA) model with the extended capability of performing rolling horizon implementation. This model is formulated as a link-based variational inequality and can be solved efficiently to convergence by a relaxation (diagonalization) algorithm. The rolling horizon mechanism makes this proposed approach a flexible tool in evaluating simulation-based DTA models. According to different assumptions of travelers' route choice behavior, three different classes of travelers are categorized: fixed (predetermined) route class, stochastic dynamic user-optimal class, and dynamic user-optimal class. Model formulation, steps of the algorithm, and rolling horizon implementation are discussed in detail. Computational examples and results are presented and analyzed.


College teachers are professional groups,their health state is not satisfying.The survey showed that college teachers are generally not in a good condition.They have chronic diseases,such as high hyperlipidemia,fatty liver,cardiovascular disease,kidney disease,hyperuricemia etc.The older they get,the prevalence of teachers grows higher,and the types of the illness become more.Thus,the health state of college teachers should be attached great importance.We should gradually improve community health care network and the overall improvement of health care facility,and strengthen health management and health education,to give better service to college faculty.College teachers themselves should also be actively engaged in physical exercise activities.


In this paper, an accurate method for determination of fault location and fault type in power distribution systems by neural network is proposed. This method uses neural network to classify and locate normal and composite types of faults as phase to earth, two phases to earth, phase to phase. Also this method can distinguish three phase short circuit from normal network position. In the presented method, neural network is trained by αβ space vector parameters.


In considering the problem of local isometric imbeddings of Riemannian manifolds M into the Euclidean spaces, it is important whether a given Riemannian manifold admits a solution of the Gauss equation in a given codimension. The author and Kaneda treated this problem in [8] and proved the non-existence of local isometric immersions of the Riemannian symmetric spaces, where the order of the codimension is about 1/2 \cdot dim M . Later, the author improved these results for special classes of Riemannian manifolds in the papers [3], [6], and gave some polynomial relations on the curvature tensor of the Riemannian submanifolds in the case of codimension 2 [4], But in higher codimensional cases, almost nothing is known at present, except for some special cases, concerning the solvability of the Gauss equation. This difficulty essentially originates in the complicated structure of the polynomial ring of the space of curvature-like tensors. (For example, compare with the simple results in the case of matrices [1], [2], [11], and the character tables of curvaturelike tensors stated in [4, p. 112, p. 130].) In this paper, to improve these results, we generalize the notion of the Gauss equation (the generalized Gauss equation), and give new conditions on the curvature tensor in order to admit a solution of the Gauss equation, by which we can prove the non-existence of local isometric imbeddings of some Riemannian manifolds that cannot be treated by previously known methods. Roughly speaking, the generalized Gauss equation, which we call the g-G-equation for simplicity, is the equation of polynomial valued 2-f0rms


In the past, there has been such a problem that a line failure could not be quickly detected on the basis of the difference between receiving times of a plurality of pieces of information. This communication device capable of solving the problem is provided with a control means which receives, from an opposite device connected through first and second lines, first information transmitted through the first line, and second information transmitted simultaneously with the first information through the second line, and a detection means which detects the line failure of the second line from the lapse of a first monitoring time without receiving the second information by the control means, after the reception of the first information.


DOI: 10.15580/GJBS.2018.2.022718032 The dynamics of Macroinvertebrates distribution and abundance in relation to Physico-chemical characteristics i.e. water temperature, air temperature, pH, transparency/turbidity, current velocity, water discharge, channel morphometry of the stream were observed. All the characteristics were monitored fortnightly over a period of three months (January – March, 2010). Physico-chemical characteristics showed little variation throughout the sampling occasion as a result of the persistent dry hot season. A total of 119 Macroinvertebrates were collected and 2 phyla identified, (Arthropoda and Mollusca). Phylum Arthropoda consisted of only one class, Insecta had 3 individuals i.e, Dystiscus, Aeshnidae and Neoperla. Phylum Molluscahad one class, Gastropoda, had three species, (Melanoides, Lymnaea species and Planorbid). Phylum Mollusca were the most abundant with 113 individuals. Submitted: 27/02/2018 Accepted: 10/03/2018 Published: 31/03/2018


This paper introduces the structural characteristic and running condition of WJF fluidized bed. Some applications show that the effect we used WJF fluidized bed to dry heat-sensitive material is much better than other normal methods. Initial humidity: 65%, final humidity: 8%, product temperature requirement : after fibrous forage enzyme whose temperature is lower than 60℃ is dried by fluidized bed, the quality of the product satisfies requirement.


A detailed analysis of the growth of a BEC is given, based on quantum kinetic theory, in which we take account of the evolution of the occupations of lower trap levels, and of the full Bose-Einstein formula for the occupations of higher trap levels, as well as the Bose stimulated direct transfer of atoms to the condensate level introduced by Gardiner et al. We find good agreement with experiment at higher temperatures, but at lower temperatures the experimentally observed growth rate is somewhat more rapid. We also confirm the picture of the ``kinetic'' region of evolution, introduced by Kagan et al., for the time up to the initiation of the condensate. The behavior after initiation essentially follows our original growth equation, but with a substantially increased rate coefficient.
Our modelling of growth implicitly gives a model of the spatial shape of the condensate vapor system as the condensate grows, and thus provides an alternative to the present phenomenological fitting procedure, based on the sum of a zero-chemical potential vapor and a Thomas-Fermi shaped condensate. Our method may give substantially different results for condensate numbers and temperatures obtained from phenomentological fits, and indicates the need for more systematic investigation of the growth dynamics of the condensate from a supersaturated vapor.


The fact that a right is unlikely to be exercised by most members of a group does not mean it has lost its social and justice-defending utility. Current attitudes can be revealed by a questionnaire, but the value of a tradition must be assessed in the light of history. Historically, academic freedom and tenure are inseparable and mutually reinforcing.


The Hongshi gold deposit is one of typical deposits from the Kanggurtag gold belt in the Eastern Tianshan,Xinjiang,NW China.Fluid inclusion and H,O,C,and S stable isotopic studies on the deposit have been carried out in this paper.The obtained data from fluid inclusion study indicate that the ore-forming fluids are rich in CO_2 and characterized by middle-low temperature,low salinity,and middle-low density.Concurrently,hydrogen(δD_(SMOW)=-104‰~-63‰)and oxygen(δ~(18)O_(石英)=13.8‰~15.5‰, δ~(18)O_水=-1.7‰~6.1‰)isotopie compositions of quartz,and carbon(δ~(13)C_(PDR)=-3.5‰~-2.7‰)and oxygen(δ~(18)O_(PDB)= -28.9‰~-26.5‰,δ~(18)O_(SMOW)=1.1‰~3.5‰)isotopie compositions of ealeite indicate that the ore-forming fluids are derived from the both the deep fluid and the magmatic fluid,and mixed with meteoric water at last stage.Sulfur isotopes of pyrite range-11.5‰~ 3.8‰ with average value of 1.73‰,implying the sulfur of ore-forming materials is characterized by deep-seated sulfur similar to that of meteorite.Briefly,the mineralization proeess of the Hongshi gold deposit can be summarized as follows:In the regional shearing regime,the deep fluids rich in metallogenic elements flow upward inside the shear system,and mixed eventually with the shallow fluids,and experience the replaeement with eountry roeks.Finally,metallogenie elements concentrate and deposit within the shear zone due to the change of physical-ehemical conditions in the shallow level.


Key Points Question What is the association of opioid prescribing duration limits with postoperative opioid prescribing in Massachusetts and Connecticut? Findings This interrupted time series analysis and cross-sectional study of 16 281 opioid-naive patients found that limit implementation in Massachusetts was associated with an immediate mean level decrease of 38 oral morphine equivalents in prescription size and with a mean decrease in slope of 1.5 oral morphine equivalents/mo. In contrast, limit implementation in Connecticut was not associated with level or slope changes in prescription size. Meaning Early evidence suggests that opioid duration limits had a variable association with postoperative opioid prescribing and should only be part of a larger, multifaceted effort to reduce excessive postoperative opioid prescribing.


Presentation and discussion of children's picture books as well as classroom meetings were implemented on a twice-weekly basis in a fourth grade classroom in an attempt to improve each student's sense of community within the classroom. A survey ("Measuring Classroom Community") which was administered to the teacher and to each student as well as interviews with the teacher and a group discussion/debriefing session with the students were used to determine the effectiveness of the six week series of interventions. Based on observations, student feedback, and teacher input, both of these interventions, used in conjunction with one another, seemed to be somewhat effective in helping to increase the overall sense of community within the classroom. Classroom Community 3 Creating a Sense of Community in the Classroom Using Children's Literature and Class Meetings Past research has spent a great deal of time examining the importance of having a sense of community amongst the teacher and the students in a classroom. Because teachers and students spend quite a bit of time together in rather close quarters it is very important that they are able to get along so that effective learning can take place without disruptions. There have been a number of studies suggesting different methods or techniques which teachers can use in their classroom in order to establish a sense of community and research has also indicated a wide range of reasons concerning exactly why a sense of community in the classroom is so very important. In examining the importance of developing a sense of community in the classroom, it is important to first have a clear understanding of exactly what is meant by a sense of community. According to Schaps, Lewis, and Watson (1996), a sense of classroom community is when students have a: feeling of being connected to, valued by, and having influence with their classmates and teacher. . .[they] feel personally known and respected. They believe they have a significant say in class planning, decision making, and problem solving. And they believe that their fellow students care about them and care about learning. (p. 29) Although each particular definition of one's sense of community varies a bit, this definition addresses most of the key points. Basically, students have a strong sense of community if they believe that their class works together as a team and cares for each other as a family would and, most importantly, if each student believes that he or she is an important and respected part of the community. Classroom Community 4 A strong sense of community within the classroom is important for a number of reasons. Johnson and Johnson (1990) suggest that a sense of community is essential if students are going to be able to work collaboratively with peers and, eventually, with co-workers in the adult world. In this context, a sense of community includes students being able to: "get to know and trust one another, communicate accurately and unambiguously, accept and support one another, and resolve conflicts" (p. 30). Without these skills, students simply cannot work together to achieve mutual goals. Furthermore, Johnson and Johnson (1990) suggest that teaching the social skills which result in a sense of classroom community results in "greater learning, retention, and critical thinking. . .greater employability and career success" (p. 32). The research of Nicholes and Kubelick (1979) suggests yet another reason for the importance of developing a sense of community in the classroom. A classroom which operates as a community not only gives the students a chance to develop their social skills but it also contributes to their moral growth and development. Nicholes and Kubelick identify six conditions which are necessary for the development of a community within the classroom and, interestingly, these six conditions are the same as the conditions for moral development. Classrooms which operate as communities provide: role-taking opportunities where students have an opportunity to see things from other people's perspectives, conflict situations that stimulate moral discussions, problem solving opportunities, dialogue among peers in small groups, exposure to higher stage reasoning, and participation in a classroom structure perceived as just and fair by the student. (p. 33) Classroom Community 5 Thus, the moral and psychological development of students in a community-based classroom is enhanced as compared to that of students who do not have a sense of community within their classroom (Nicholes & Kubelick, 1979). According to Meltzoff (1994), teachers are responsible for much more than simply passing on information to their students. While that is important, it is also very important that they build a community in their classroom and that they teach their students "to be both strong individuals and members of communities" (p. 13). That is, students must learn basic skills and knowledge but they also must learn how to get along with others so that they are prepared to become participating citizens within the greater community once they have completed school. Meltzoff uses the analogy of weaving in an attempt to describe exactly what she believes is necessary in order to build a community within the classroom. In this analogy, she suggests that a classroom is like weaving because "each individual strand interacts with others to form an integrated whole" (p. 15). Just as each strand of yarn in weaving goes together to collectively make a pattern, students in a classroom also work together to build the relationships which then define their classroom community. In particular, Meltzoff discusses ten strands which go into the weaving of a classroom community and suggests that the more strands which are present in any given classroom, the better the sense of community is in that classroom. The ten strands which blend together to create a classroom community are: "shared leadership, responsiveness, communication, moral unity, cooperation as a social process, shared history, shared environment, identification/involvement, wholeness, and interdependence" (p. 16). Essentially, this means that the teacher and students both contribute equally to what will go on in the classroom each day, students consider not only their own needs but also the needs of their classmates, everyone works towards common goals and for the good of the entire group, students each identify


Programming Language Popularity "langpop.com" provides information on 33 different programming languages. Glancing at this website reveals that old programming languages never die and new programmi...


Treatment with insulin allows diabetic patients to manage their disease. Nevertheless, the need to frequently monitor blood sugar levels and properly regulate insulin dosage is not trivial. The possibility to advance from management of diabetes to a cure is therefore of great interest. Cadaver-derived islets transplanted to replace diseased pancreatic islets have proved the feasibility of such an approach. Current research focuses on stem cells as a resource to create functional islet cells or to induce the regeneration of existing pancreatic cells. On pages, 139–152, Kinkel and Prince provide a comprehensive review of the use of zebrafish embryos as a model system to identify the signalling molecules involved in the complex process of pancreatic development. Genetic manipulation using the zebrafish model offers the possibility of tracking reporter genes optically which provides a distinct advantage over mouse models. While pancreas development in zebrafish and mouse share many similarities, the differences can offer opportunities for insight into general mechanisms that would otherwise remain difficult to tease apart. In particular, the zebrafish model has been especially helpful in uncovering extrinsic signalling pathways in early pancreatic morphogenesis that will be particularly useful in stem cell research. Stefani Eames


This article points out the chief factors, barriers of knowledge and barriers of non knowledge, which have influences on students'listening level. It offers some unique approaches to improving students' listening skills such as combining intensive listening with extensive listening. Meanwhile, teachers and schools should exert every effort to create environment for students' English learning.


This study presents the results of chromate adsorption upon chitosan modified with thiourea, glutaraldehyde. Firstly modified chitosan was synthesized by using thiourea, glutaraldehyde and chitosan at different molar ratios and adsorption capacities were compared to the original chitosan. The modified chitosan showed higher Cr (VI) retention performance than the original chitosan. While the original chitosan had a percent removal of 32% at an initial concentration of 50 ppm, the percentage of chitosan removal improved to 99.9%. Kinetic and thermodynamic constants are determined at appropriate ambient conditions and adsorption is defined by appropriate adsorption isotherms. Langmuir isotherms were found to be suitable for characterizing the adsorption of chitosan with the modified Cr (VI) ions. Under appropriate experimental conditions, percentages of removal in Cr (VI) removal studies by adsorption using modified chitosan reached 99% and adsorption capacity of 442 mg/g was observed.Characterization of the modified chitosan and original chitosan were characterized by FTIR (Fourier Transform Infrared Spectroscopy), TGA (Thermal Gravimetric Analysis), XRD (X-ray Diffraction) and DSC (Differential Scanning Calorimetry) .


In this article, we calculate scalar propagator in arbitrary dimensions and gauge and the three‐point scalar‐photon vertex in arbitrary dimensions and Feynman gauge, both at the one loop level. We also discuss constraints on their non perturbative structure imposed by requirements of gauge invariance and perturbation theory.


To determine B‐type natriuretic peptide (BNP) levels in infants and children with acute lung injury (ALI), and to investigate associations between BNP levels and clinical outcome.


Background A subset of polycythemia vera (PV) patients harbor mutations in a discrete region of exon 12 in the JAK2 gene. So far more than 40 individual mutations have been described involving amino acids 533 to 547 including substitutions, deletions, and duplications. Several studies have indicated that a higher JAK2 V617F mutant allele burden may be associated with a more extreme PV, but both the variability and rarity of the JAK2 exon 12 mutations have limited the number of studies describing how they reflect disease development and influence thrombotic events. To investigate the impact of the JAK2 exon 12 mutant allele burden on the disease phenotype and its utility as a prognostic marker, we established a European collaboration termed JAK2 Exon 12 Mutated Allele Burden Study (JETMABS).

Results Eighty six samples from 66 individual JAK2 exon 12 positive PV patients (median age 64 years, range 32-88 years) were collected from participating centers and mutant allele burden was determined by allele specific qPCR evaluating 11 different JAK2 exon 12 mutations. Depending on the participating center the DNA was either purified from whole blood (n=36; mutated alleles, median 20%, range 1.0-99%) or from granulocytes (n=30; mutated alleles, median 21%, range 8.9-51%). These were divided into separate groups as purification of DNA from granulocytes appeared to result in a slightly higher estimated mutant allele burden, as expected. The vast majority of patients had a mutant allele burden below 50% regardless of the source of DNA (60 out of 64 patients). Both hemoglobin (Hb) (Spearman r=0.41, P<0.05) and hematocrit (Hct) (Spearman r=0.49, P<0.05) levels correlated significantly with the mutant allele burden in the samples purified from granulocytes. The pre-diagnosis thrombotic events did not correlate with the mutant allele burden, but the two cases with the highest mutant allele burdens (88% and 99%) were the only ones to experience thrombotic events post-diagnosis. Four patients developed non-hematological secondary cancers, two patients progressed to post-PV myelofibrosis, and one patient developed AML.

Conclusion The JAK2 exon 12 mutant allele burden did not seem to influence the pre-thrombotic events in PV patients. The allele burden only exceeded 50% in a few cases, which was associated with post-thrombotic events. Although this does not seem to reflect the dynamics of the more aggressive JAK2 V617F counterpart, these few patients may require a more intensive treatment strategy.

Disclosures: No relevant conflicts of interest to declare.


ABSTRACT The activity of NCX 972, a new molecule obtained by adding a nitric oxide (NO) moiety to metronidazole, was tested against six isolates of Entamoeba histolytica in xenic cultures. NCX 972 released NO into trophozoite cells and enhanced killing of amoebas in a dose- and time-dependent manner compared to metronidazole.


: In the context of rapid social development, artificial intelligence has been effectively developed, which has greatly improved social productivity and promoted the healthy development of society. At present, artificial intelligence technology has been applied in mechanical engineering and electronic fields, and has achieved certain application results. To stimulate the vitality of social development, China must continue to deeply study the application methods of artificial intelligence technology in the field of Electromechanical industry, master the application skills, and give full play to the positive role of artificial intelligence technology. This paper mainly analyzes the application characteristics of artificial intelligence technology and electromechanical engineering, inspects the correlation between artificial intelligence and electromechanical engineering, and inspects the application of artificial intelligence in electromechanical engineering, hoping to provide effective guidance for the application of artificial intelligence technology in electromechanical engineering.


The association constant, Ka of Na+ with [12]crown-4, [15]crown-5 and [18]crown-6 crown ethers were determined in a binary mixture, 1,4-dioxane/water (50/50) using a Na+ ion selective electrode at different temperatures. Ka values were determined with the relationship, 1/Ka [Lo]n+m–1 = (1–nP′)n(1–mP′)m/P′, for various stoichiometries, (n:m), where P′ is the mole fraction of the complexed cation. The exothermic association constants and the thermodynamic data for cation–macrocycle complexes explained in terms of Eigen–Winkler binding mechanism are given. The binding power found for Na+, however, was the highest with [18] crown-6.


Identifying the morphological findings of vitality is crucial when determining if a lesion was inflicted in life or postmortem [...].