Time Perspective Theory (TPT) predicts that all quantum experimental results will vary with the scale of the instrumentation involved in any measurement. For example; The Davisson-Germer Experiment, involved observations between the detectors angular measurements (at the observers scale) and electron behavior (at quantum scales). TPT predicts that if detecting instruments can be scaled and positioned much closer to the point of beam scattering the intensities would become more isotropic, proportionately. This concept of perspectives between scales sheds some light on the Double Slit Experiment. TPT offers an alternate explanation to the "undetermined probability wavefunction Ψ". In TPT, wavefunction is a time perspective distortion between the scale of the observer and the scale of the particle. In the "Double slit experiment", the "collapse" is resolved when an optical plate (or any measuring instrument) is introduced at the scale of the particle. Subsequently, the measurement becomes no longer between scales, but rather at the same scale. Although TPT is analogous to the distortions of spacial perspective, TPT addresses distortions in the time dimension (perspective vs orthogonal). TPT proposes that the same convex distortions and divergence which occur in space during magnification, also occurs in time. Subsequently, if a particle's motion (v) is viewed as pluralistic in time, so then is it's position d/t. TPT has great implications in Macro-space, as well. Time intervals appear to decrease and converge to a single event. Subsequently, decreased time intervals appear as increased velocity. See figure 1. Thus, Photons travelling to an observer from remote past events will appear to arrive with successively decreased time intervals. TPT provides a simple alternative explanation for: wavefunction, the "Double slit experiment", accelerated universal expansion, millisecond pulsars and the galaxy outer rim rotation problem. – (C) Pletcher 2015 FIG. 1. Viewed in perspective, linear expansion is equivalent to the derivative of accelerated expansion.


This experiment monitors the population of the lowest triplet state by directly observing phosphorescence intensity as a function of time.


Chaos motions and its control of Henon-like system are studied by numerical calculation in the paper.The bifurcation diagram and Lyapunov exponent of the system are presented to analyze the transition from periodic motion to chaotic motion.Chaotic phase diagram is given.Then chaos of the Henon-like system is effectively controlled to freewill expectation point by the method based on Lyapunov exponent.Numical simulations show the effectiveness and applicability of the method.


We provide a framework for Bell inequalities which is based on multilinear contractions. The derivationof the inequalities allows for an intuitive geometric depiction and their violation within quantummechanics can be seen as a direct consequence of non-vanishing commutators. The approach is motivatedby generalizing recent work on non-linear inequalities which was based on the moduli of complexnumbers, quaternions and octonions. We extend results on Peres' conjecture about the validity ofBell inequalities for quantum states with positive partial transposes. Moreover, we show the possibilityof obtaining unbounded quantum violations albeit we also prove that quantum mechanics can onlyviolate the derived inequalities if three or more parties are involved.


Dental pulp derived cells are pluripotent stem cells which can be differentiated along odontogenic, osteogenic, adipogenic, or neurogenic lineages. Odontogenic and osteogenic differentiation, in the absence of dexamethasone, have been shown to be highly dependent on substrate morphology and mechanics. Here we focus on neurogenic differentiation, using the protocol described by A. Arthur et al., and its dependence on substrate nature. DPSCs were cultured on PLA, a biodegradable polymer approved for internal use. The upregulation of genetic markers was compared with that of cells plated on standard TCP. The role of substrate morphology was investigated by plating on electrospun fibers approximately 2.0 ± 1.0 μm in diameter and on spin-cast thin films. The influence of graphene was investigated through the addition of 3% and 10% graphene nanoparticles to the films and fibers respectively. The aspect ratio of the cells was measured using confocal microscopy. Cells grown on graphene containing substrates had larger aspect ratios than their non-graphene counterparts, and cells grown on microfibers were longer than their counterparts on the flat films. But the cell aspect ratio did not necessarily correlate with genetic differentiation. The results after 21 days of incubation indicated that early markers (TBP, β-III tubulin), decreased uniformly on all substrates relative to day 0, with the largest decrease occurring on the PLA flat film with graphene. The late stage marker, NEFM, which indicates differentiation, was upregulated to a significantly larger extent on all PLA substrates. No difference was observed between the fibers and the flat film in the absence of graphene, thus morphology did not play a significant role on this polymer. Addition of graphene did not affect the outcome on the fibers, but significantly suppressed the gene expression on the flat films. These results indicate that PLA is a promising scaffold material for neurogenic differentiation.


n the past decade, many of the most influential and innovative theorists in the human and social sciences have come to recognize that the hallmark of the postmodern moment is the waning in influence of older subject-object philosophical paradigms upon which the great traditions of Cartesian and Kantian idealism, as well as Marxist materialism, were constructed. From the remains of transcendental philosophy and the materialist dialectic, a new philosophical paradigm has emerged, one in which-as Fredric Jameson has recently suggested-dialectical "contradiction" is replaced by systemic "differentiation," the Cartesian cogito by the concept of "subject position," and, in the realm of political theory, class consciousness and representative democracy by the shifting strategic alliances of what Ernesto Laclau and Chantal Mouffe have called "chains of equivalence," which are themselves not based on any foundational identity (of class, of gender) but are instead thoroughly contingent and ad hoc relations forged in a social field riven by a ceaseless, constitutive "social antagonism." In the broadest terms evoked by our title, what used to fill the place


Hepatocellular carcinoma (HCC) is one of the most common cancer worldwide, and has a high degree of malignancy and poor prognosis. Early diagnosis and treatment of HCC would significantly improve clinical outcomes. Near infrared (NIR) laser and photo-absorbing agent-based photothermal therapy (PTT) is an emerging therapeutic hyperthermia approach, and has been suggested as a minimally invasive and highly efficient therapeutic method. Reduced graphene oxide (rGO) is one of the most typical photothermal agents. Compared with other materials, rGO possesses some advantages, such as simple synthesis, low cost, high photo-stability and large surface area for drug loading. However, rGO exhibits poor dispersibility and difficult modification due to loss of the hydrophilic functional groups during the reduction process. Thus, the modification processes of rGO are always complicated, time-consuming, and require some expensive polymers. In this paper, human serum albumin (HSA) was functionalized with indocyanine green (ICG) and lactobionic acid (LA) to prepare multifunctional human serum albumin (mfHSA), which could be used for the modification of rGO. This approach is simple and highly efficient, and not only improves the stability and the biocompatibility of rGO, but also makes it exhibit an enhanced photothermal conversion efficiency and targeting specificity towards HCC cells. The low cytotoxicity and the high PTT therapeutic efficacy at both the cellular and animal levels indicated that the prepared multifunctional nanomaterials could serve as a highly effective therapeutic agent for HCC.


The first order Hartree–Fock equations of the 1s2p3s4P0 state of the three-electron atomic systems have been solved exactly. These solutions are used to evaluate Hartree–Fock energy up to third order with high accuracy. The third order Hartree–Fock energies for Li to Ne7+ are compared with those derived from experiment and other theoretical calculations.


Objective To study the influence of sodium ferulate on the hemorheology in patients with primary nephrotic syndrome.Methods 50 patients with primary nephrotic syndrome were randomly divided into two groups: therapy group treated with prednisone combinated with sodium ferulate and control group treated with prednisone.We tested 24-hour urine protein,plasma viscosity,blood sedimentation,heatocrit,plasma albumin,triglyeride and cholesterol before and after the treatment.Result In therapy group,plasma triglyeride and cholesterol decreased obviously than that in control group(P0.05),and blood viscosity,plasma viscosity,blood sedimentation and heatocrit also decreased more obviously than that in control group after the treatment(P0.05).Conclusion That prednisone combinated with sodium ferulate treat nephrotic syndrome can reduce the blood fat,correct the hyperviscosity and improve the prognosis of the disease.


Transfusion associated graft versus host disease (TA-GvHD) is a rare complication of transfusion treatment with blood products containing viable lymphocytes. The risk of developing TA-GvHD depends on number and sustainability of lymphocytes in blood product, host's immune system reactivity and the difference in human leukocyte antigen (HLA) system between donor and recipient. Standard method of TA-GvHD prevention is irradiation of blood products with ionizing radiation and absorbed dose of 25-50 Gy. The aim of irradiation is inactivation of viable lymphocytes in blood product containing cells (red blood cells, platelets, granulocytes) and lymphocyte proliferation inhibition in blood product recipient. In the last two decades, gamma irradiation has been extensively abandoned and replaced with specially designed cabinet machines using X-ray irradiation which are suitable for hospital and blood bank use. This reduces the risk of accidental or deliberate misuse of radioactive source, solves radioactive waste disposal issues and reduces ionizing irradiation exposure of employees in blood establishments. In Blood Bank of Croatian Institute of Transfusion Medicine, X-ray irradiation of blood products has been carried out since 2014 with a year rate of 20,000 irradiated cell blood products used in treatment of patients at risk of developing TA-GvHD.


Taylor and Francis Ltd RTPE_A_370564.sgm 10.1080/14 59390802703941 echnology, Pedagogy and Education 475-939X (print)/174 -5139 (online) Edit ri l 2 09 Assoc ation for Infor ation Technology in Teacher Education 8 0 000March 2009 SteveKe newell st ve.k ll@ ihe. c.uk As I write this at the end of 2008, I am fairly confident some exciting new technology will emerge during 2009. After all, this has been the pattern for many years now, and the effects of the recession will not have worked through the development cycle for new products. I shall call this technology X, since I don't know what it is. And, just as in algebra we can confidently make statements about patterns using symbols such as x, I think we can use the patterns in the history of technology in education to confidently predict that:


for presentation on the development of fermentation on demand capability to accelerate industrial biotechnology Commercialization Capability and Strategic Partnerships by BioEconomy Partners Managing Partner, Ally LaTourelle, Esq. If the biobased economy is to grow at the predicted pace, commercialization strategies will continue to be a critical factor to hurdle the well known commercialization gap. However, biobased technology companies are often forced to make?the difficult choice between high cost contract fermentation or capital intensive construction. BioEconomy Partners is currently the developer of FermCo, Inc's fermentation toll manufacturing plant called the Bioscience Manufacturing Center in Rochester, NY. This company will bridge the gap for emerging biotech companies and reduce their "front end" capital expenditures. FermCo, Inc. fills a critical market gap for costeffective, timely, toll fermentation for biobased technology companies and their partners. FermCo's Bioscience Manufacturing Center is?a 60,000 square-foot advanced manufacturing facility to be located at Eastman Business Park?in Rochester, NY. This will be a uniquely product flexible, state-of-the-art, 2,000,000-liter general purpose fermentation facility for the production of biobased chemicals and fuels. FermCo will be fully equipped with an IP protected facility design, private analytical labs and a staff experienced with bacteria, yeast, fungi, algae, organic acids, amino acids, solvents, biomass/ single cell protein, foods/food ingredients, feed ingredients, and enzymes to help guide strain development alongside a customer's technical team. The uniquely flexible process system design of three trains of pilot scale fermenters and six commercial scale fermenters will allow companies an ability to model and develop at pilot size, or produce at commercial scale, or both. Each of the three trains will have one 5,000-liter preseed fermenter, and one 40,000-liter seed fermenter. These trains can be used as stand-alone pilot tools, or as seed fermenters for full scale production with any or all of the six 350,000-liter production fermenters. This process design allows for both start-up and established biotechnology companies to quickly and effectively scale up laboratory fermentations, and then move to batch fed or continuous fermentation at commercial scale as needed. The development of a Fermentation hendrucOn Demand capability will accelerate industrial biotechnology companies into greater Commercialization Capability and Strategic Partnerships. This presentation will outline the development strategy of the FermCo, Bioscience Manufacturing Center, it's Fermentation on demand capability, and the emergence of collaborative strategic partnerships that make it possible to move technologies in tandem, to commercial scale, at multiple points in the supply chain. Nathan Hillson, Joint BioEnergy Institute The Berkeley Open Biofoundry: A biological foundry to support US biomanufacturing Lawrence Berkeley National Laboratory and the University of California, Berkeley seek to establish the Berkeley Open Biofoundry (BOB), a unique public-private partnership to rapidly advance the state of the art for biomanufacturing. BOB will be an open collaboration facility, providing researchers and manufacturers across industry, government, and academia the ability to develop, test, and implement state-of-the-art biological designs for robust production of desired targets (e.g., engineered microbes that produce drop-in chemicals, engineered plants that produce novel polymers, etc.). BOB's core research and development mission will enable the use-inspired application of biomanufacturing across a broad range of industries, from renewable fuels, chemicals and materials to pharmaceuticals and agriculture. Biomanufacturing holds great promise to deliver new drugs, new chemicals, new materials, new agricultural techniques, and more, but the current cost and time required to develop a product limits its impacts. The typical process for engineering biology involves an iterative loop of Design (D), Build (B), Test (T), and Learn (L). Due to the unpredictability of much of biology, the complexity of the D, B, and T steps, and the lack of learning incorporated into future designs, one cycle of the loop can take months and benefits minimally from previous cycles. BOB targets the inefficiencies in engineering biological systems to improve the state of the art from its current ad hoc status to one that is robust, predictable, and scalable. BOB will use both formal representations of biological and process knowledge with process modeling and machine learning to integrate the DBTL cycle, advancing the process of engineering a biological system from years to weeks and improving the success rate of that engineering effort from 2.5% to ~50-70%. Beyond better organism design, BOB will also improve the process of scaling biomanufacturing so that the systems developed will make it to market with higher success rates and less development time (and thus less money). By developing methods to predict how organisms will perform in reactors, BOB will take bioprocess development from a time-consuming process done one strain at a time to a process that is predictable and reliable. As an open collaboration facility, BOB will bring together researchers across industry, government and academia to develop and apply innovative biomanufacturing technologies for key applications. In doing so it will become a premier source for publicly available materials and data, including well-characterized, predictably engineerable host organisms, genetic expression systems, biosensors, metabolic pathways and enzymes, and protocols and technologies for strain construction, characterization, and production optimization. Session 5: Potential for Increased Productivity, Through Enzyme Optimization Wednesday, Jul 22 8:30 am 10:00 am Room: 519 B Moderator: John Perkins, DSM Subramani (Subbu) Ramachandrappa, Richcore Lifesciences Novel patent pending enzyme solutions for treating Industrial waste water / sewage and replacing sulphur in production of plantation white sugar from sugar cane RICHECOSOL TECHNOLOGY: AN ECO-FRIENDLY SOLUTION FOR TREATING INDUSTRIAL AND DOMESTIC WASTE WATER. Background: Although there have been continuous efforts to develop an efficient enzymatic technology to treat industrial and domestic waste water, the application of the idea so far has not been fully practical because of one important reason: The Cost. Richcore Lifesciences has developed a cost effective technology platform that enables developing a medley of enzymes to process complex substrates. The platform can be used to custom design, develop and produce an optimum mixture of specific enzymes at a cost that is a fraction (1/10th) of conventional enzyme manufacturing method, enabling the use of greener, enzyme based solutions in highly price sensitive applications such as industrial waste water and sewage treatment. Technology (patent pending): The RichEcosol technology enables co-culturing multiple strains to produce a mix of 35+ enzymes in single fermenter using minimal energy and equipment. This consortium of enzymes is effective in hydrolyzing various substrates such as dyes, aromatics, phenolic compounds & bio-molecules which are generally found in waste water in various proportions. Application: Increasing the efficiency of industrial waste water/sewage plants without additional Capex and with reduced chemical usage. Improving bio-methanation and bio-remediation processes. Benefits: Incrementally, up to 50% reduction in BOD & COD, 60 to 90% reduction in color, 20% reduction in sludge, 60% reduction in phenol and with additional savings of 30% in total costs. Status: Being commercialized across various industries including paper and pulp, textiles and refineries. Global Potential: In excess of USD 1 billion/year. SULPHREE: A TECHNOLOGY TO REPLACE/SUPPLEMENT CURRENT PRACTICES FOR REMOVING COLOR DURING SUGAR MANUFACTURING PROCESS. Background: Color of sugar is an important commercial attribute; hence, color removal is a very critical step in manufacturing plantation white sugar. In Asia & parts of Latam, Sulfur Dioxide (Sulphitation) is still used to produce white sugar. Sulfur use leads to severe health risks for employees in the plant and to the end customers consuming sugar with residual Sulfur. Also, Sulfur use leads to increased corrosion in the plant, and pollutes surrounding areas through effluents. Technology (patent pending): The enzyme complex in Sulphree breaks down color forming compounds such as pigments and phenol compounds; thereby preventing color formation and reducing the color of the juice. The enzymes also catalyze the breakdown of hemi cellulosic polymers in cane juice; thus reducing turbidity, enhancing juice clarity, and preventing formation of high molecular weight colorant-polysaccharide complex. Application: Eliminates or reduces the use of Sulfur in production of plantation white sugar. Benefits: Eliminates health risks to operators and Sulfur in discharged effluent, reduces corrosion in sugar plants, and leaves no residual Sulfur in final sugar. Sugar mills benefit through direct cost savings, increased yield (3-5%) and a better pricing by offering Sulfur free white sugar. Status: Commercially tested and validated. Global Potential: Close to USD 800 million/year. Company is in advanced commercial licensing discussions with global chemical companies. RICHCORE LIFESCIENCES is an innovation led biotech company developing novel solutions for Cleantech and Biopharma. Thu Vuong, University of Toronto Enzyme engineering for enzyme-based devices and biomaterial applications Sarocladium strictum gluco-oligosaccharide oxidase was known to effectively oxidize cello-oligosaccharides and lactose; however, our current characterization indicated that this enzyme oxidizes xylooligosaccharides and other sugars at a


THE breeding display of Greater Prairie Chickens (Tympanuchus cupido pinnatus) has been described by several authors (Breckenridge 1929, Bent 1932, Hamerstrom 1941, Schwartz 1945, Hamerstrom and Hamerstrom 1960, Robel 1964). All mentioned the importance of aggressive behavior and territoriality during the display season. Previous research on Prairie Chickens in Kansas has shown that socially dominant males are responsible for most copulations on booming grounds (Robel 1970). Mating success of males has been correlated with social rank, which was characterized by different levels of aggression (i.e. dominant males highly aggressive). During 1970 and 1971 we studied the importance of dominant males within a stabilized booming ground social organization, especially as related to reproductive success. Our study involved observing male and female behavior both before and after the removal of dominant males from a booming ground.


57 ABSTRACT A chlorine-free bleaching process for lignocellulosic pulp characterized by a series of bleaching stages com prising in sequence a peroxide bleaching stage, the per oxide being selected from the group consisting of alka line hydrogen peroxide, acidic hydrogen peroxide, and peroxy acid and at least one ozone bleaching stage and in one embodiment the sequence including an initial oxygen bleaching stage before the peroxide bleaching stage. In continuous operation the effluent from each of these sequential stages provides the preferred wash for the preceding washing step and the diluent for the pre ceding bleaching stage, the final effluent being recycla ble for effective closed cycle operation.


These days one of the major inevitable ailments for females is bosom malignancy. The
appropriate medication and early findings are important stages to take to thwart this
ailment. Although, it's not easy to recognize due to its few vulnerabilities and lack of data.
Can use artificial intelligence to create devices that can help doctors and healthcare
workers to early detection of this cancer.
In This research, we investigate three specific machine learning algorithms widely used to
detect bosom ailments in the breast region. These algorithms are Support vector machine
(SVM), Bayesian Networks (BN) and Random Forest (RF). The output in this research is
based on the State-of-the-art technique.


The title compound, C10H12N2O2, was prepared by the reaction of o-hydroxyhypnone and acetohydrazide. In the structure, there are intramolecular C—H⋯N and O—H⋯N, and intermolecular N—H⋯O and C—H⋯O hydrogen-bond interactions.


In this paper, the effect of the geometric representation of cucumbers on the numerical simulation of its cooling kinetics is studied. It is supposed that the diffusion model with boundary condition of the third kind satisfactorily describes the cooling, and that the thermo-physical parameters are constant during the process. The geometries used to represent the cucumber are: infinite cylinder, finite cylinder, and ellipsoid. The diffusion equation was solved through the finite volume method, with a fully implicit formulation, using cylindrical and generalized coordinates. The convective heat transfer coefficient and the thermal diffusivity were determined through optimization, using the inverse method. The best model in the representation of the cucumber's shape was the ellipsoid, but the time demanded in its optimization was about 66 times greater than the time for the infinite cylinder. Additional key words: convective heat transfer coefficient; Cucumis sativus; cylindrical coordinates; diffusion; finite volume method; generalized coordinates; thermal diffusivity.


We present investigations of the optical gain cross section of 1.54 μm Er-related emission at 4.2 K in Si/Si:Er molecular-beam-epitaxy-grown multinanolayers. This ultranarrow (full width at half maximum below 8 μeV) emission originating from the unique Er-related optical complex, Er-1 center, ensures the best condition to achieve stimulated emission. The experiments were carried out using a combination of the variable stripe length and shifting excitation spot techniques under pulsed and continuous-wave excitations. The comparison of results for both excitation regimes enables to estimate an optical gain within the strong optical losses due to the free carrier absorption. Based on these measurements, the upper limit of the optical gain cross section of 10−17 cm2 and the gain coefficient of 8.8 cm−1 are deduced.


The mechanisms regulating expression of IgA subclasses are poorly understood. While adult serum contains ˜90% IgAl and ˜10% IgA2, breast milk contains a 40/60 mix respectively. In the present study colostrum was collected from 11 donors (days 1–5 post-partum), the cells washed through a fetal calf serum cushion, separated over ficoll-Hypaque, and twice washed with buffer. The mononuclear cell fraction was assessed by Wright-Giemsa stain and flow cytometry using fluorescein-conjugated monoclonal anti-T4, T8, IgA1 and IgA2 antibodies. A strong correlation was found between the % lymphocytes and % IgA2+ cells (R=.842).The T4/T8 ratio did not correlate, and averaged 1.11+/−.67No correlation was found with surface IgAl+ cells.The findings are consistent with a model which proposes either recruitment to or expansion of sIgA2+ lymphocytes in colostrum.


The objective of this study was to identify factors influence households to use and maintain latrines. This information is needed to scale up community led total sanitation programs in the Ermera District of Timor-Leste. The respondents were males and females 18-65 years of age in Haupu village. In order to access information from the subjects, the study was designed as a cross-sectional survey, based on a quantitative data design. The study was conducted in February 2013. Overall 417 respondents agreed to participate and data were collected using a structured questionnaire and were analyzed using chi-square tests of significance. The study found that 47.2% of households continued to use and maintain latrines and 52.8% had stopped by one year after the open defecation free declaration in Haupu Village. There were several factors that influenced households to continue use of or stop using latrines, namely socio-demography, knowledge, attitude and practice, socioeconomic status and environmental factors. It was found that there were significant associations between latrine use and gender (p-value=0.002), level of education (p-value<0.001), occupation (p-value =0.005), income (p-value <0.001), neighbors having a latrine (p-value<0.001), neighbor influence to build a latrine (p-value <0.001), knowledge (p-value =0.002), attitudes (p-value <0.001) and practices (p-value <0.001). There were 3 variables without significant associations namely: marital status (p-value 0.204), water source (p-value 0.959) and age (p-value 0.095). More than half of the households stopped use and maintenance of latrines by one year after the open defecation free declaration. There were significant associations between latrine use and socio-demography, knowledge, attitude and practice, socioeconomic status and environmental factors. Education and knowledge are essential elements to be improved, especially for those living in rural areas. Collaboration within relevant ministries, institutions and among partners are the key important roles to monitoring and supervise the sustainability of latrine use and maintenance in the future.


purpose of this research is to find out what is the legal basis for the authority of the Constitutional Court in resolving disputes over the results of the General Election of Regional Heads in Indonesia and how the effectiveness of the authority of the Constitutional Court in disputes over Regional Head General Election. The method used in this research is juridical normative, namely, the materials collected by conducting a literature study. The authority of the Constitutional Court in judging at the first and last levels whose decisions are final in deciding disputes regarding general elections, there are several paragraphs that discuss the extent to which the authority of the Constitutional Court in resolving disputes over the General Election of Regional Heads has been contained in Article 157 of Law Number 10 2016 concerning the Second Amendment to Law Number 1 of 2015 concerning Stipulation of Government Regulations in Lieu of Law Number 1 of 2014 concerning the Election of Governors, Regents and Mayors which form the legal basis for the authority of the Constitutional Court in resolving disputes over the results of the General Election in Indonesia.


To the Editor.— From the outset, implementation of the Medicare End-Stage Renal Disease (ESRD) Program has been complicated by problems of inadequate or inaccurateinformation of policies and progress. Considerable attention has been given to recent articles and testimony suggesting that the total costs have far exceeded expectations and that the Department of Health, Education, and Welfare failed to recognize or support in-home dialysis and transplantation as the preferable, and least costly, treatment alternatives. The following information will record that these suggestions are incorrect. In late 1972, before implementation of Section 2991 of the Social Security Amendments of 1972 began, a comprehensive analysis of the cost and survival implications of various dialysis and transplantation alternatives, including life-cost tables factoring multiple permutations of incidence, mortality, treatment pathway, and patient distribution, was developed by the Office of the Assistant Secretary for Health. Compared with the actual experience for the first five years,


Using thermochromatic liquid crystal to measure surface temperature, an automated transient method with time-varying free-stream temperature is developed to determine local heat transfer coefficients. By allowing the free-stream temperature to vary with time, the need for complicated mechanical components to achieve a step temperature change is eliminated, and by using the thermochromatic liquid crystals as temperature indicators, the labor intensive task of installing many thermocouples is omitted. Bias associated with human perception of the transition of the thermochromatic liquid crystal is eliminated by using a high speed digital camera and a computer. The method is validated by comparisons with results obtained by the steady-state method for a circular Jet impinging on a flat plate. Several factors affecting the accuracy of the method are evaluated.


We obtain estimates in Besov, Triebel-Lizorkin and Lorentz spaces of differential forms on R-n in terms of their L-1 norm.


This article examines the long-term consequences of a historical human capital intervention. The Jesuit order founded religious missions in 1609 among the Guarani, in modern-day Argentina, Brazil, and Paraguay. Before their expulsion in 1767, missionaries instructed indigenous inhabitants in reading, writing, and various crafts. Using archival records, as well as data at the individual and municipal level, I show that in areas of former Jesuit presence—within the Guarani area—educational attainment was higher and remains so (by 10%–15%) 250 years later. These educational differences have also translated into incomes that are 10% higher today. The identification of the positive effect of the Guarani Jesuit missions emerges after comparing them with abandoned Jesuit missions and neighboring Franciscan Guarani missions. The enduring effects observed are consistent with transmission mechanisms of structural transformation, occupational specialization, and technology adoption in agriculture.


Multiple measures of managerial performance, including the increased use of non-financial measures exist widely in the business world. Using a principal-agent model with moral hazard, we study a special case of two performance measures - production and internal quality. We derive a condition when agents respond to an increase in incentives for internal quality performance by decreasing the level of internal quality effort provided. This happens where the agent's effort can be allocated between internal quality performance and production performance and incentives for internal quality performance are at a sufficiently high cost of incentives for production performance. We further show with numerical analysis that such a condition is possible in the optimal solution. In the benchmark case with one measure of performance, this condition did not arise. Our results provide analytical support to the notion that the use of multiple measures of performance should be accompanied by a careful analysis of their interactions.


This paper reviews the nature and requirements of the vital interfacing for legacy equipment and examines ways in which improvements might be made in the light of higher-level developments. With trip output devices that are suitable for direct initiation of the circuit breaker (CB) trip circuits and with integral trip circuit and trip output supervision, the old-style process level interfacing could be improved and simplified by the arrangement described in this paper. If interposing relays are still required to provide suitably rated contacts for control purposes, they can be back-of panel mounted with the digital control system (DCS) bay control units, but with no other special requirements.


According to World Health Organization, this global pandemic (COVID-19) has severely impacted the world and now the number of people infected is above fifty million. As prescribed by all doctors and scientist across the world Wearing face masks and following safe social distance are two of the enhanced safety protocols need to be followed in public places in order to prevent the spread of corona virus and save human life. We need to create safe environment for humans and animals as well. For that sole purpose, we propose an efficient and reliable computer vision-based approach in the real-time for monitoring people to detect both safe social distancing and face masks in public places by implementing the model using OpenCV. After detection of breach, the system sends alert/notification signal to concerned authority and also give alarm to public. In this proposed system modern deep learning algorithm have been mixed with geometric techniques for building a robust model which covers three aspects of detection, tracking and validation. Thus, the proposed system favors the society by saving time and helps in lowering the spread of corona virus by monitoring social distancing norms. In the current situation when lockdown is eased to inspect persons in public gatherings, shopping malls, etc., It can be implemented effectively. Automated inspection reduces manpower to inspect the public and also can be used in any place. We have gone through some papers for reference and we have written about them in this paper. IndexTerms covid-19, social distancing, restricted zone, region of interest, computer vision.


Metabolomics is an important branch of systematic biology.It has received great attention around the world,especially in microbiological research field,and new progress has been also made.The metabolomics of lactic acid bacteria has become one of the hottest research topics.This review summarizes the major techniques involved in the research procedures of the metabolomics of lactic acid bacteria,including sample preparation,analysis and identification of metabolites and data analysis.The applications of the metabolomics of lactic acid bacteria are also given based on several typical examples.At the same time,we discussed the potential problems of the metabolomics of lactic acid bacteria,and points out the future of this research.


The utility model discloses a multi-body-position massage treatment bed. A caster wheel lifting box is vertically fixed on an underframe; a lifting platform is fixedly connected with a lifting T-shaped stand fixedly connected to the underframe; one end of the lifting electric ejector rod of the lifting platform is fixedly connected to the lifting T-shaped stand while other end thereof is fixedly connected to the lifting platform; the upper end of the lifting T-shaped stand is fixedly connected with a bed surface; and a head part massage cushion, a waist part massage cushion and a leg part massage cushion are sequentially fixed on the bed surface; the bed surface below the head part massage cushion is fixedly connected with one end of a lifting gas spring of the head part massage cushion; the other end of the lifting gas spring of the head part massage cushion is fixedly connected to the lifting T-shaped stand; one end of the lifting electric ejector rod of the waist massage cushion is fixedly connected to the bed surface below the waist massage cushion while the other end thereof is fixedly connected to the lifting T-shaped stand; and one end of the lifting gas spring of the leg part massage cushion is fixedly connected to the bed surface below the leg part massage cushion.


This note examines the impact of rising bond yields in certain Euro Area countries on debt sustainability. It concludes that without the financial assistance of the bailout packages, government debt in Greece would clearly have been unsustainable, while Ireland and Portugal would have been extremely vulnerable. We also examine the case of vulnerable countries which have not received bailouts — Italy, Spain and Belgium. We conclude that while they can absorb some temporary rise, as has been seen in recent weeks, a significant further sustained rise — more than 100–200 basis points — would call their solvency into question in the absence of financial assistance.


In this article, we analyzed and discussed the differences in spike skill between volleyball and beach volleyball. In terms of the beach volleyball's characters, we found that such soft straight arm attack ways are the essential activities of the spike skill in beach volleyball match. We have realized what some problems in our training is that the training way has not matched the demand of the beach volleyball match .So, firstly , in beach volleyball training at spike skills we should liberate from the fixed training thought given by the volleyball's training mold and find out the new content and demand of spike skill belonging beach volleyball in its training.


The judgment of the Spanish Constitutional Court (CCJ) 177/2016 overturned the ban on bullfighting in Catalonia that had been established under Catalan Law 28/2010 of 23 August. This prohibition, implemented within the framework of the autonomous community's competences in the areas of animal protection and public entertainment events, was declared unconstitutional in a rather hasty manner and without the decision being thoroughly reasoned by the Spanish Constitutional Court (SCC). The Court does not analyse the aforementioned competences but rather places them under the domain of the State law on shared competence for cultural heritage. This situation is a consequence of bullfighting having been included in this category on the basis of two state laws that were enacted subsequent to the Catalan norm. In this regard, the SCC ruling interprets jurisdictional concurrence within the area of cultural heritage in an unprecedented manner, granting Article 149.2 of the Spanish Constitution (SC) full functional content, a controversial aspect in the doctrine until now. This means that state legislation enacted under its umbrella takes precedence over any autonomous-community regulation where it has an impact. This is related to both the specific matter in question and to any other competences that fall exclusively within the domain of the autonomous community, some of which, including public entertainment events and public order, are of major relevance. The fact that the Court limits its reasoning to this apodictic approach excludes any reference in the judgment to other issues of substance that were also raised by the petitioners. These include the charge that the autonomous community's banning of a cultural activity also has an economic dimension that affects individual free enterprise and freedom of movement, as well as artistic creation. Finally, the SCC judgment fails to make a doctrinal analysis of issues such as the regulation of animal protection, which despite being new, also have a strong social dimension.


The treatment of deltamethrin (10 g a. i./ha) proved most effective against fruit borer followed by endosulfan (1.0 lit./ha.) and HaNPV (400LE/ha) and neemgold (1.25 lit./ha.) proved least effective followed by Trichogramma chilonis (4.5 lac/ha.), azadirachtin (1.5 lit./ha.) and Bt kurstaki (0.5 kg/ha.) and Bt aizawai (0.5 kg./ha.) existed in middle order. The maximum yield of marketable tomato fruits and minimum avoidable loss was obtained in deltamethrin followed by endosulfan and HaNPV, whereas, minimum yield was recorded in the treatment of azadirachtin followed by neemgold and T. chilonis. The maximum net profit of Rs. 44,569/ha was obtained in the treatment of deltamethrin followed by endosulfan (Rs. 38,789/ha) and HaNPV (Rs. 36,187/ha.). The minimum net profit of Rs. 16,484/ha was obtained in the treatment of azadirachtin followed by T. chilonis (Rs 18,175/ha) and neemgold (Rs 18,473/ha). The highest B: C ratio was computed in the treatment of deltamethrin (46.66:1) followed by endosulfan (32.44:1) and HaNPV (16.77:1) and lowest (3.11:1) in T. chilonis treatment.


We present an algorithm for calculating the geometric intersection number of two multicurves on the $n$ -punctured disk, taking as input their Dynnikov coordinates. The algorithm has complexity $O(m^{2}n^{4})$ , where $m$ is the sum of the absolute values of the Dynnikov coordinates of the two multicurves. The main ingredient is an algorithm due to Cumplido for relaxing a multicurve.


Pseudoaneurysm of the left hepatic artery in a patient with chronic pancreatitis complicated with obstructive jaundice.

A pseudoaneurysm of the left hepatic artery that causes an obstructive jaundice is a rare entity that has only been described a few times in scientific literature. We describe the case of a patient with a giant pseudoaneurysm (10 cm diameter) caused by chronic pancreatitis, that compresses the choledochus duct.

The diagnosis was made by CT scan (computed tomography). The treatment consisted of a ligation of the afferent and efferent artery and evacuation of the aneurysmatic mass. A persisting bile leak was caused by a haemobiliary fistula between the aneurysmatic sac and choledochus duct. Therefore, a hepaticojejunostomy was performed with a delay of 4 weeks.

The patient recovered after a few weeks and left the hospital in a good condition.


The real-time detection and tracking of moving objects is a challenging task and automatic tools to identify and follow them are often subject to constraints regarding the environment under investigation or the full visibility of the targeted object. Exploiting the possibility of a multisource acquisition in the targeted scene, firstly detection is performed by means of characteristic features extraction and storing in a database; secondly, the tracking task is approached using algorithms, where automatic search involves occluded or masked targets in the scene. This latter problem is solved through database retrieval, based on well-defined multi-modal features. The method has been tested on case studies regarding the identification and tracking of animals moving at night in an open environment (i.e. natural reserves or parks), and the surveillance of known scenes for unauthorized access control.


The poetry of Pablo de Rokha is crossed by a complex system of food's representation, recipes, places for preparation and consumption, animal, plants and hum...


Ektaphelenchus masseyi n. sp. is described and illustrated. The new species was isolated from dead/rotten wood collected from natural forests in north Iran. It is characterised by 501-758 μm long females having three lines in lateral field, more or less continuous cephalic region separated from the body only by a shallow depression, relatively short tripartite stylet (total length 13-14 μm) lacking basal knobs or swellings, excretory pore at base of metacorpus or slightly anterior to it, post-vulval uterine sac 24-32 μm long, rectum and anus absent, posterior body region conical with finely rounded terminus, and males rare, with a dorsally convex and ventrally flat tail with a small mucron at terminus, 13-15 μm long spicules, and seven caudal papillae. The new species was morphologically compared with typologically similar species of Ektaphelenchus having three lines in the lateral field, namely E. joyceae, E. macrobulbosus, E. taiwanensis, and E. winteri. It was further compared with E. olitorius and E. prolobos having a similar female posterior body end shape and with an unknown number of incisures in the lateral field. It was also compared with three species currently placed under Ektaphelenchoides, namely E. andrassyi and E. poinari with three lines in the lateral field, and E. compsi with obscure lateral lines. The molecular phylogenetic relationships of the new species with other ektaphelenchid species were investigated using partial small, and large subunit ribosomal RNA gene (SSU and LSU rDNA D2-D3) sequences using the maximal number of currently sequenced ektaphelenchid and seinurid taxa.


"Each case will have a point to it," said Jeffrey Rastatter, MD, FAAP, a member of the AAP Section on Otolaryngology-Head and Neck Surgery (SOOHNS). "Sometimes that point might be making a diagnosis, but sometimes that point might be choosing a particular treatment or making the appropriate next-step decision, whether follow-up in a clinic vs. referral to the emergency room vs. prompt referral to specialist within a week."


Objective:To establish the testing method of microbial limit for Shenju Lotion.Methods:Routine method,medium diluting method,membrane filtration method and centrifuging and membrane filtering method were used for the test of the microbial limit on Shenju Lotion.Results:Shenju Lotion had higher antimicrobial effects:bacteria,molds and yeasts must be eliminated by centrifuging and membrane filtering method.Staphylococcus aureus and Pseudomonas aeruginosa were counted by membrane filtration method.Clostridium sporogenes was tested by medium diluting method. Conclusion:This method is feasible and the result is consistent with the requirement in Edition 2005 Pharmacopoeia of PRC.


Abstract In the paper research on foreground object segmentation in dynamic background scenarios (i.e. flowing water, moving leaves or shrubs) is described. The effectiveness of different algorithms: based on FIFO sample buffer, singlevariant, multi-variant (MOG, Clustering) and recently proposed ViBE and PBAS is evaluated. A post-processing method, that allows false detections reduction is also proposed. The solution was tested on sequences from the changedetection.net dataset. The obtained results indicate usefulness of the proposed approach.


In this paper, we present a way to represent contradiction between fuzzy sets. This representation is given in terms of the notion of f-weak-contradiction. Unlike other approaches, we do not define contradiction just by using one of the relations of f-weak-contradiction but by considering the whole set of relations. This consideration avoids the need to fix an operator beforehand in order to take into account all the information between two fuzzy sets. As a result, we characterize the contradiction between fuzzy sets and define a family of measures of contradiction satisfying four interesting properties: symmetry; antitonicity; if the intersection is empty, then the measure is one; and if there is an element in the intersection with degree of membership 1, then the measure is zero.


Spatial coordinates determined optically from Richland, Washington, for 13 recent SAR arcs are transformed to L intercepts at 400 km. The resulting L values for the SAR arcs are mapped into the magnetic equatorial plane. The locus is found to be a segment of an asymmetric ring. The ring conforms approximately to the expected intercept of the plasmapause in the same plane. Proximity of the SAR-arc field lines to the plasmapause, the electron trough, and the ring current is discussed and the observed north-south drifts of SAR arcs are reviewed.


Abstract Scotland, like many other countries, is undergoing a transition to renewable energy. This paper discusses the social context within which this transition is taking place and which is conditioning the possibilities for energy development and its effects on people. In particular, the paper explores historically-rooted conflicts relating to land rights and wild land protection, considering these issues and their relationship to energy development in terms of landscape justice (i.e. the principle of fairness in the ways people relate to the landscape and to each other through the landscape). Pursuing a more just settlement between people and landscape is often a matter of understanding problematic pasts and working to overcome their harmful legacies. It is argued that there is an important role for heritage practice in helping to deliver energy development which takes the historical, social and cultural context more fully into account and thereby helps to bring about a more just settlement between people and the landscape.


Abstract We consider the prescribed mean curvature problem of spacelike graphs in Robertson- Walker spacetimes of flat fiber with homogeneous Dirichlet conditions on an Euclidean ball. Under reasonable assumptions, it is shown that every possible solution must be radially symmetric. Besides, an existence result for a singular nonlinear equation is proved by making use of the classical Schauder fixed point Theorem. The results are applied to realistic examples of Robertson-Walker spacetimes.


Safrole (5-Allyl-benzo (d)(1,3) dioxole) was isolated from essential oil of sassafras (piper hispidinervum) (piperaceae). It was subjected to photooxidation reaction in the presence of hematoporphrin, tetraphenylporphrin or rose Bengal as singlet oxygen sensitizer under irradiation of sodium light led to (E)-5-(3-hydroperoxyprop-1-1-enyl) benzo (d)(1,3) dioxol (II). Probably, novel hydroperoxide is generated insitu upon irradiation of safrole in the presence of DNA, and they can be responsible for some adverse effects in living cells. Therefore, it seems to be relevant to elucidate biological consequences of hydroperoxide with DNA and other cell components.


Communication between design team members is critical to ensure a project's success particularly during the early stages of the design process. Effective design teams rely on the collective knowledge of their members who increasingly include participants from diverse disciplinary domains. Thus communication, including integration of specialized knowledge and negotiation of differences among domain specialists, has emerged as a fundamental component of the design process [1]. An important aspect of communication is the role that visual communication practices, visual representations, and visual thinking play in the success of a design team. While much attention has been given to the use of external representations as aids in the internal problem solving process, and the visualization tools available to assist in the creation of those visual representations (sketching, diagramming, 3D modelling, mind mapping, storyboarding etc.), little has been studied regarding their communication role within multidisciplinary teams. This paper presents three different applications of visualization tools—visualization tools for conceptual development, for collaboration, and for presentation—that emerged during the study of eighteen multidisciplinary design situations. The successful use of visualization tools and their products (visual representations) supported knowledge exploration, integration, and collaboration by transferring information across discipline boundaries. While all of the visual representations were used for communication purposes, team members were not evenly skilled at generating visual representations and at communicating through the use of visual representations. These differences were discipline–based and were critical in defining team interaction and team leadership. Implications for design methods, tools and education are discussed.


Abstract : This report describes the development of several new computer based strategies for teaching troubleshooting principles to electronics technicians. The computer programs to implement these strategies were developed in part from software produced in previous contracts. The report documents an experiment in which those materials were presented to student technicians to determine their attitudes toward the techniques, and to determine whether the resulting training resulted in improvement of their technical skills. Results in both cases were positive with students responding very favorably to the materials and with their performance improving quantitatively and qualitatively after the instruction. The computer based techniques used are explained and examples of student interaction with the materials are included in the report. Copies of the tutorial materials used in conjunction with the on-line computer presentations are presented in an appendix. (Author)


Water vapor transfer from a model leaf set in a wind tunnel and that from citrus leaves formulating a canopy in the field were measured by using the leaf-like surface evaporimeter method due to HASESA and TAKECHI (1973), in order to make clear the wind dependence of forced convection water-vapor transfer coefficients over leaves within plant canopies. Local evaporation rates (w) at the point of 2cm from the leading edge of a leaf-like surface evaporimeter were determined respectively in the model and citrus canopies.The following relation was used to separate the effect of buoyancy term from the measured evaporation rates and to determine the local transfer coefficient due to forced convection(Df)Df, EXP=w/ΔC-Dn, CALCwere, ΔC is the departure of water-vapor concentration at the wet surface of the model leaf from that in the general air flow and Dn, CALC the water vapor transfer coefficient due to free convection. Because the leaf-like surface evaporimeter is flat, smooth and rigid, it is possible to assum that the influence of three factors such as leaf-fluttering, surface roughness and leaf curvature upon the transfer coefficient can be disregarded. The comparison between measured water-vapor transfer coefficients and standard coefficients (Df, STD) calculated from theoretical relations for a flat plate (in longitudinal flow) similar to the evporimeter in the size and surface temperature distribution enabled us to make clear the influence of canopy air-flow on the transfer coefficient over leaves.The results obtained for the surface evporimeter in longitudinal air flow are as follows:1. The water vapor transfer coefficient due to forced convection over the model leaf set in the front of model canopy agreed satisfactorily with those calculaled from the laminar boundary layer theory, because the air flowing on the model leaf was free from the air disturbance by the model canopy.2. Although the wind dependence of transfer coefficients over the model leaf set within and behind the model canopy was expressed by the 1/2 power law, the absolute values were to some extent larger than theoretical values. The difference between measured and calculated transfer coefficients was gradually large with the increment of leaf area density of the model canopy. When the leaf area density was retained constant throughout experiments, the values of transfer coefficient were independent of the tion of the model leaf within the model canopy along the direction of air-flow.3. Under the conditions that the model leaves were oriented so as to shelter behind windward leaves, values of exponent of the wind-transfer coefficient ranged betweeh 0.6 and 0.7. In this case, the fetch-dependence of the watervapor concentration over the surface of the model leaf was quite similar to that over a flat plate on which turbulent boundary-layer was built up.4. When the model leaves were set at different distances behind the model canopy, the influence of air-flow disturbance due to the canopy upon the water vapor transfer coefficient diminished gradually with increasing the distance from the canopy.In order to study the effect of the angle of attack of air flow on the water vapor trasfer, experiments with the model leaves inclined against the horizontal plane at different angles were carried out in the model canopy. As can be seen in Fig. 4, in the range of inclination angle between 10° and 20° the values of transfer coefficient were somewhat larger in comparison with those over a flat plate in longitudinal air flow. However, the effect of inclination angle on the transfer coefficient over the model plate decreased rapidly with departure from that inclination range and the values of transfer coefficient became nearly equal to or slightly smaller than the standard transfer coefficient.


An efficient acquisition scheme based a synchronization strategy is proposed for multiple access in the process of ultra-wideband (UWB) communications under multipath conditions. Receiver attains synchronization through two steps, i.e. original synchronization and time-hopping (TH) acquisition. Owing to resolving the difficulties into two simple steps, this scheme can improve effectively the pulse position modulation (PPM) UWB acquisition performance.


This paper proposes a method of using multithreading technology in optimization calculation, and discusses the model of multithreading optimization calculation, programming method, and measures of realizing the communication and synchronous control among all the threads. This can remarkably promote the stability and efficiency of optimization calculation.


An eight-level diffractive microlens (DML) array for beam splitting is designed and fabricated by a LIGA-like process. The pattern of this dual-focal-point DML was designed using the optimal rotation-angle method and realized by silicon etching, nickel (Ni) electroplating and hot embossing. Tetraethoxysilane (TEOS) oxide etching and specially designed demold techniques were developed and employed in the fabrication process to minimize the related processing errors such as misalignment and tilting so that the accuracy of DML could be ensured. The obtained poly(methyl methacrylate) (PMMA)-based DML was measured to confirm the optical properties and the results showed that the diffraction efficiency error and uniformity error were successfully kept under 5.19 and 1.52%, respectively.


BACKGROUND:
Detecting presence of invasion of bone and finding effect on surrounding structures is important from diagnosis, treatment planning and prognosis point of view. Conventionally Multidirectional CT is used to detect presence of Bone Invasion in cases of Malignancy involving mandible. Recently CBCT is found to be more sensitive in detecting bone invasion in mandible. In addition CBCT provides advantage of radiation safety, Economic superiority and resolution superiority over MDCT. This study was conducted to assess the CBCT Features of malignancy involving mandible and find association of radiological features with clinical and histopathological features.
AIM OF THE STUDY:
The Aim of this study is to evaluate Cone Beam Computed Tomography in analysis of Patients of Malignancy involving mandible
OBJECTIVE:
Objective is to Interpret Cone Beam Computed Tomography changes in axial, coronal, sagital and three dimensional images of Malignancy involving mandible., to Associate Imaging feature with Clinical Features, to Associate Imaging feature with other Imaging features and to Associate Imaging feature with Histopathological diagnosis.
METHODOLOGY:
Total 30 patients reporting to the Department of Oral Medicine and Radiology were included in the study, based on inclusion and exclusion criteria. Patients with complaints and Clinical features suggestive of Malignancy of the mandible were assessed with CBCT after which incisional biopsy was performed to get a confirmatory final diagnosis based on the histopathological features. The patients who were histopathologically confirmed to have bone invasion were then taken up for the evaluation with the CBCT scans already taken.
RESULT:
The study showed maximum cases (35%) with invasion in relation to Right Posterior Alveolus. Spread of invasion was more than clinical limits of the lesion. Spread of bone invasion in mandible was faster in antero posterior direction than in supero inferior direction. The Erosive pattern was found exclusively in lesions presenting as Ulceroprolifearative growth, Cases of verrucous presentation had mixed pattern, Lesions presenting as ulcer had infiltrative pattern. 27% patients had pathological fracture, amongst these cases out of which 75% were females. All cases presenting as ulcerative lesion had IA Canal perforation present. 100% of cases with infiltrative invasion had cortical destruction of IA Canal and 54% of mixed invasion lesion had IA Canal intact. 36% teeth had loss of lamina dura, PDL Space was widened in 61% of cases and Tooth displacement was found in 22% of case. Following CBCT examination all the cases were graded as Stage IV in TNM staging.
CONCLUSION:
In this study it was found that Spread of invasion is found to be more extensive than clinical limits and is more in Anteroposterior direction than superoinferiorly direction. Lesions presenting as Endophytic growth were aggressive in terms of bone invasion. There was no association between Histopathological feature and CBCT Features.


The paper aims to present the characteristics of the net given through the prism of supporters and skeptics. That range reveals net traps at social platforms through the crisis of democracy as an introduction to netocracy, and at the individual platform. A particular problem that arises from this is the definitions of media literacy that are focused on life in the media. The paper presents completing the definition of media literacy with the term "exclusion", which leads to life with media.


Sabarimala is a Hindu journey focus spotted in the Western Ghat mountain reaches of Pathanamthitta area in Kerala. Sabarimala Shree Dharma Sastha Sanctuary, devoted to Master Ayyappa, is the most acclaimed and noticeable around all the Sastha sanctuaries in Kerala. The sanctuary is arranged on a topmost ridge (something like 3000 feet above sea level) named Sabarimala in Pathanamthitta district. The altar of Sabarimala is a standout amongst the most remote sanctums in southern India, yet regardless it attracts three to four million travelers every year. This is a standout amongst the most aged sanctuaries in Kerala. It is accepted that the god of the sanctuary was sanctified by Master Parasurama at the foot of Sabari mounts for which reference has been made even in Ramayana. The sanctuary draws in travelers not just from the southern states of Kerala, Tamil Nadu, Karnataka and Andhra Pradesh but also from different parts of the country and also from abroad.


Foreword Part I. Overview: History of Correctional Design, Development, and Implementation of Direct Supervision as an Innovation: 1. Introduction 2. Historical view 3. The development of direct supervision as a design and management system 4. Post occupancy evaluations of the earliest DS jails 5. Effectiveness of direct supervision models Part II. Environment-Behavior Issues in Corrections: 6. Correctional space and behavior 7. Prison crowding 8. The psychology of isolation in prison settings 9. The effects of noise in correctional settings 10. Windows, light, nature, and color Part III. A Model and Conclusions: 11. An environmental and contextual model of violence in jails and prisons 12. Conclusion.


The aim of this study was to examine the relations of academic achievement, self-efficacy, and perfectionism with procrastination in University students, and to examine whether procrastination can be predicted by academic achievement, self-efficacy, and perfectionism dimensions. 227 University students from different faculties completed Tuckmans' procrastination scale, Almost Perfect Scale – Revised (APS-R; Slaney Rice, Mobley, Trippi, & Ashby, 2001) and General self-Efficacy Scale (GSE; Schwarzer & Jerusalem, 1995), as well as data about academic achievement at the end of last academic year. Results have shown negative correlations of academic achievement, self-efficacy and adaptive perfectionism with procrastination, and a positive correlation between maladaptive perfectionism and procrastination. Results have also shown that self-efficacy is positively correlated with adaptive perfectionism and negatively with maladaptive perfectionism. Maladaptive perfectionism was a positive predictor of procrastination, while academic achievement, self-efficacy and adaptive perfectionism were all negative predictors. Finally, we used Hayes bootstrapping method to examine possible mediations. The results have shown that self-efficacy, by its self, is not a significant mediator, while paths containing self-efficacy and adaptive or maladaptive perfectionism mediate the relation between academic achievement and procrastination. Furthermore, both adaptive and maladaptive perfectionism mediated the relation between self-efficacy and procrastination.


The small and medium enterprises (SMEs) have contributed to the economic growth and competitiveness of many countries. However, as the SMEs continue to grow as an important entity in many economies including Malaysia, many factors have dampened such progress. While previous studies had focused on its macro perspective in terms of firm level and industry level performance, this study attempted to address the basic issue of SMEs employees in terms of their job performance. This study is underpinned by the theory of job performance and further supported by the theory of congruence. The main objective of this research is to investigate on the relationship that may exist between three variables comprised of competency, person-job fit and the employees' job performance in the context of service SMEs. Using a quantitative method, a sample of 324 responses was collected using a mail survey from 1500 distributed questionnaires. Results show significant relationships between competency, person-job fit and the job performance of employees. Conclusions and implications of the study were discussed.


The energy stored in Electrical Vehicles can back up the grid during low-generation periods produced by, for instance, unpredictable renewable energy generation. Therefore, Vehicle-to-Grid (V2G) technologies are foreseen as a major player in the energy transition. However, V2G technologies face several barriers: inadequate technology maturity, lack of interoperability, and unknown business models. In this context, this paper aims to describe the main benefits and challenges of V2G technology. Furthermore, a detailed revision is presented regarding EVs charging systems, interoperability protocols and players, and grid integration requirements.


Following a critique of previous theories of the dielectric aerial, a theoretical model is proposed based on the concepts of scattering theory. It is shown that the model is essentially an extension of the theory of polarization of dielectric materials. Application of the scattering model yields an inhomogeneous Fredholm integral equation, the solution of which is the aerial radiation pattern. Explicit equations are deduced for both TM01 and HE11 mode excitation of solid dielectric rods and numerical solutions have been obtained. The solutions compare favourably with those of previous methods. Extensions of the theory to other dielectric structures, such as tubes and inhomogeneous rods, are also discussed.


The charge-density wave (CDW) is a modulation of the density of conduction electrons in metals, which is coupled to displacements of the atoms according to a wave with the same wavelength (same wave vector) as the modulation of the conduction band [1]. The classical CDW is the stable state of quasi-1-dimensional (1D) metallic crystals at low temperatures. The latter possess crystal structures with obvious 1D features, like chains of atoms supporting 1D electron bands, and these materials display a highly anisotropic electrical resistance, with the low resistance in the direction of the 1D atomic chains. The mechanism is Fermi-surface nesting (FSN), where a single wave vector q connects to each other different parts of the Fermi surface. A modulation of the atomic positions according to a wave with this wave vector q leads to a lowering of the electronic energy. The accompanying elastic strain then leads to an optimal magnitude of the atomic displacements, the latter which can be measured by x-ray diffraction (XRD). More recently, CDWs have been found in metals whose crystal structures and physical properties lack obvious 1D features 3]. Mechanisms have been put forward, that provide alternative explanations for the formation of CDWs. In particular this includes q dependent electron-phonon coupling (EPC). The EPC peaks at a particular wave vector q . A static modulation with this wave vector then leads to a lowering of the energy of the system, which is not purely electronic, but should be attributed to the EPC terms. Here, we present comprehensive studies towards CDWs in the materials La 3 Co 4 Sn 13 , CuV 2 S 4 and Er 2 Ir 3 Si 5 with strong electron correlations [4 – 6]. Temperature-dependent


It is clear that the cost efficiency is becoming a major driver in future space missions. Because of the constraints on total cost, including design, implementation and operation, future spacecraft are limited in terms of their size, power and complexity. Consequently, it is expected to have future missions operate on marginal space-to-ground communication links which, in turn, can pose an additional risk on the successful scientific return of these missions. For low data rate and low downlink margin missions, the concept of buffering the telemetry signal for further signal processing to improve data return has been widely adopted. The paper describes techniques used for post-processing of the buffered telemetry signal segments (called gaps) to recover data lost during acquisition and resynchronization. Two methods, one for a closed-loop and the other one for an open-loop configuration, are discussed. Both of them can be used in either forward or backward processing of signal segments, depending on where a gap is specifically situated in a pass.


It's no exaggeration to say that floods are among the most common and catastrophic natural disasters, with widespread impacts on ecosystems and human lives. The World Bank has concluded that India is one of the most flood-prone countries in the world. This research has been focused on identification of real-time flood hazard area in the Malda district (India) using SAR data, Sentinel-1A (C-band). ArcGIS, Erdas-Imagine, and SNAP were used for this analysis. These inundation layers were intersected with the Malda district village's database to determine the full extent of the devastation caused by the floods and finally determined the real-time flood-impacted area (380.19 km² on 4th September and 338.87 km² on 10th September, 2019). It was noted that on 4th September, 766 and 10th September 765 villages were seriously devastated owing to water. Moreover, among the 15 blocks of this district, Harischandrapur-II (75.67%), Manikchak (68.60%) and Kaliachak-III (68.00%) have experienced the most flooding. Finally, in order to estimate the overall population, households and affected by the floods, stratified random sampling was carried out in the flood-impacted villages of the Malda district. The safest blocks are Chanchal-I, Gazole, Harischandrapur-I and Kaliachak-I and the highly vulnerable blocks are Harischandrapur-II, Kaliachak-III and Manikchak. According to the flood influences on children, the most vulnerable blocks are Malda Old, English Bazar, Kaliyachak-III, and Harishchandrapur-II.


A Mobile Ad-Hoc Network is a collection of mobile nodes that are dynamically and arbitrarily located in such a manner that the interconnections between nodes are capable of changing on continual basis. Due to security vulnerabilities of the routing protocols, wireless ad-hoc networks are unprotected to attacks of the malicious nodes. One of these attacks is the Black Hole Attack. The black hole attack is one of the well-known security threats in wireless mobile ad hoc networks. The intruders utilize the loophole to carry out their malicious behaviors because the route discovery process is necessary and inevitable. In this paper we presented a review on few aspects of Black hole attack in MANET's. We have tried to discuss about the reasons why such attacks are seen in mobile ad- hoc networks and performed an analysis on its performance and result on a few of its simulation parameters.


Abstract This paper reviews the interdisciplinary projects carried out during the last 25 years in eastern Liguria (NW Italy). These have brought together archaeologists, geographers, palaeobotanists and historians in a series of research exercises based upon many different types of evidence: archaeological excavation and survey, ecological analysis of existing landscapes, geoarchaeological, anthracological and palynological analyses. Taken together, the results of this research provide a rich source of material for developing an understanding of how humans in eastern Liguria have interacted with the landscape through time. The influence of human activity on the vegetation of Liguria, in the Late Neolithic, Copper Age (Chalcolithic) and Bronze Age, is part of a complex system of agricultural activity mainly involving transhumant pastoralism. Several peat sites and buried soils have supplied the palaeoecological data that indicate the considerable effect of this economic activity on the landscape: a reduction in fir woodland, a decrease in arboreal species and an increase in the diversity of light demanding herbaceous and fern taxa. The environmental and economic changes during the 4th and 3rd millennia BC in eastern Liguria are also testified to by the starting of quarrying and mining activities to obtain both red jasper and copper.


EXECUTIVE SUMARY In this subtask, the manufacturability of hybrid carbon-glass fiber-reinforced composite wind turbine blades using Vacuum-Assisted Resin Transfer Molding (VARTM) was investigated. The objective of this investigation was to study the VARTM process and its parameters to manufacture cost-effective wind turbine blades with no defects (mainly eliminate dry spots and reduce manufacturing time). A 2.5-dimensional model and a 3-dimensional model were developed to simulate mold filling and part curing under different conditions. These conditions included isothermal and non-isothermal filling, curing of the part during and after filling, and placement of injection gates at different locations. Results from this investigation reveal that the process can be simulated and also that manufacturing parameters can be optimized to eliminate dry spot formation and reduce the manufacturing time. Using computer-based models is a cost-effective way to simulate manufacturing of wind turbine blades. The approach taken herein allows the design of the wind blade manufacturing processes without physically running trial-and-error experiments that are expensive and time-consuming; especially for larger blades needed for more demanding environmental conditions. This will benefit the wind energy industry by reducing initial design and manufacturing costs which can later be passed down to consumers and consequently make the wind energy industry more more » competitive. « less


The present work deals with the modeling and the stability of the cascade converters. When a converter tightly regulates its output, it behaves as a constant power load (CPL). The problem of CPLs is that they show negative incremental resistance that causes instability in the system. Hence the CPL has been modeled and linearizaed to study its effect on the source converter. On this basis, it was found that because of the negative resistance exhibited by the CPL, the control to output transfer function possessed a RHP pole and thus makes system unstable. The effect of the introduction of small resistance in series with inductor of source converter on the stability was analyzed. Also the compensation on the basis of the passive components i.e. snubbers were designed so as to reduce the power dissipation due to the resistance. Type III compensation was designed by taking the input impedance of the load converter as the load for the source converter using K factor method. Further, based on input impedance, minor loop gain concept was used for stabilizing the system.


Abstract The Electrical Sounding Tool and Its Applications in the Determination of the Slip Surface at Gota, Western Sweden A new method of locating slip surfaces of landslides by means of electrical resistance sounding is described. The method is based on the fact that, for an undisturbed clay, the variation of salinity with depth (indicated approximately by the resistance curve) is slight and gradual. Very different salt distributions to this are found, however, in the Gota River Valley, Sweden, where numerous large landslides have occurred. Here the salinity of the clay is normally greatest in the vicinity of the river and diminishes as the distance from the river increases. When a slide occurs, however, the upper clay layers move riverwards, so that clay of lower salinity comes to rest above clay of higher salinity. The resistance curve will thus show, at the junction of the two clays of unlike salinity, a sharp step representing the slip surface. This conclusion is checked by the extraction of clay c...


The present work reports a tridimensional reconstruction of the intratesticular seminal pathway in the hamster as studied with light microscopy of serial sections of the proximal pole of the testis. It has three portions: a "terminal segment" of the seminiferous tubules; the tubuli recti with three parts; and the rete testis with two parts, intratesticular and extratesticular.


The goal of this study was to assess the impact of leadership style, work motivation, and work discipline on employee performance in one of automobile dealer company. This study employs quantitative research methodologies, as well as data gathering strategies such as questionnaire distribution and library data. Non-probability sampling with saturation sampling approach was applied on 90 workers. Multiple linear regression analysis was utilized to analyze the data using the SPSS. The findings revealed that the variable of leadership style had a substantial impact on employee performance. Employee performance is significantly influenced by work motivation. Employee performance is significantly influenced by work discipline.  Employee performance is influenced by leadership style, job motivation, and work discipline all at the same time. The percentage indicates that the factors of leadership style, work motivation, and work discipline can explain more than 90% of the employee performance variable. Other variables not investigated in this study account for 7% of the variance.


The change of the output of generating unit mass wind farms can cause access the network voltage fluctuations, serious when can make voltage collapse. Based on reactive power compensator (STATCOM) synchronization of wind power system, and the grid STATCOM can exchange the perceptual reactive and capacitive reactive, restrain system voltage fluctuation, maintain the stability of the system voltage. Wind power system discussed in the basic working principle and STATCOM control strategy and establish the relevant model, and the simulation of the actual system. The simulation results show that STAT-COM to maintaining the system, improve the wind power system voltage stability has a good result.


Employees are a common element and the most important resource in every institution and most important resource any organization can have. The employee's total wellbeing therefore, according to Nzuve (1997) is not only important to themselves but equally so to the employer. This is in agreement with Cooper's (1980) observation that the Human Relations School is founded on the assumption that people who are happy, satisfied with good mental health will make the most effective employees. Robbins (1996), concurs with the above studies by quipping that there are some stable individual attributes that affect experience in and reaction to the workplace. It is in view of these findings that UNESCO (2002), report indicates that due to the changing nature of work, there is need for workplace wellness. There is an increasing need to go beyond the factory model and create a workplace that is knowledge-driven with ample room for innovation, flexibility, and quality and customer service. Within this context, new working arrangements are being developed.


Ecclesiastes Chapter 3 states that there is a time for everything under the heavens from reaping and sowing to mourning/grieving, but likewise there is a time to live in the light once again. Every aspect of time's passing has to be dealt with, and the past cannot be clung to as a safety harness without causing more suffering and grief. The ideology of this scripture is paramount to the work by Abraham-Klein, who deals compassionately with the subject of loss of a parent and the necessary stages of grief and mourning. This is an aspect of life that everyone will at some time face and be required to deal with, the question is how do we do it?


Lead titanate (PbTiO3) thin films have been deposited on silicon, platinum-coated silicon and titanium silicide by RF-magnetron sputtering from pressed powder targets. The film structure was investigated by X-ray diffraction and was found to be strongly dependent on substrate temperature. Dielectric properties of the films are reported.


In 1988, 217, 825 ha were treated with herbicide for forest management purposes in Canada. Ontario treated the largest absolute number of hectares but New Brunswick had the highest intensity of treatment in terms of percentage of productive forest, cutover or planted area treated. Seventy-six percent of the herbicide was applied aerially. Eighty-five percent was for release. Forest managers across Canada have identified a number of gaps in herbicide technology including the need for: alternatives to herbicides, demonstration areas for the public, assessment methodology, long-term cost/benefit analysis, more information on effects on wildlife habitat, and aerial navigation aids.


Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B5) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate utilization. In this study, on the hunt for pantothenate analogues with increased potency relative to those reported previously, we screened a series of pantothenamides (amide analogues of pantothenate) against P. falciparum and show for the first time that analogues of this type possess antiplasmodial activity. Although the active pantothenamides in this series exhibit only modest potency under standard in vitro culture conditions, we show that the potency of pantothenamides is selectively enhanced when the parasite culture medium is pre-incubated at 37uC for a prolonged period. We present evidence that this finding is linked to the presence in Albumax II (a serum-substitute routinely used for in vitro cultivation of P. falciparum) of pantetheinase activity: the activity of an enzyme that hydrolyzes the pantothenate metabolite pantetheine, for which pantothenamides also serve as substrates. Pantetheinase activity, and thereby pantothenamide degradation, is reduced following incubation of Albumax II-containing culture medium for a prolonged period at 37uC, revealing the true, submicromolar potency of pantothenamides. Importantly we show that the potent antiplasmodial effect of pantothenamides is attenuated with pantothenate, consistent with the compounds inhibiting parasite proliferation specifically by inhibiting pantothenate and/or CoA utilization. Additionally, we show that the pantothenamides interact with P. falciparum pantothenate kinase, the first enzyme involved in converting pantothenate to coenzyme A. This is the first demonstration of on-target antiplasmodial pantothenate analogues with sub-micromolar potency, and highlights the potential of pantetheinase-resistant pantothenamides as antimalarial agents. Citation: Spry C, Macuamule C, Lin Z, Virga KG, Lee RE, et al. (2013) Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated. PLoS ONE 8(2): e54974. doi:10.1371/journal.pone.0054974 Editor: Stuart Alexander Ralph, University of Melbourne, Australia Received October 5, 2012; Accepted December 21, 2012; Published February 6, 2013 Copyright: 2013 Spry et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: Aspects of this work were supported by grants from the South African Malaria Initiative (SAMI) to ES and KJS and the American Lebanese Syrian Associated Charities (ALSAC), St. Jude Children's Research Hospital, to REL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: firstname.lastname@example.com ¤ Current address: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom


A survey of aphids was carried out during 2008 to 2009 in central parts of Iran by collecting and identifying them and their host plants. Aphids were collected from 83 host plants. Seventy seven species from 37 genera, belong to 5 families include: Aphididae, Drepanosiphidae, Pemphigidae, Lachnidae, Phloeomyzidae were recorded. According to collected data, these families have the highest total identified species and distribution respectively. The greatest diversity of aphids was found on plants of the family Asteraceae . Furthermore, the family Asteraceae has the greatest host plant species for aphids. A list of aphids and their host plants is presented in this study.


See next page for additional authors Follow this and additional works at: http://ro.ecu.edu.au/ecuposters Part of the Sports Sciences Commons This poster was originally published at: Farley, O. R. L., Andrews, M., Secomb, J. L., Tran, T. T., Lundgren, L., Abbiss, C., & Sheppard, J. M. (2014). The validity and inter-unit reliability of custom-made SurfTraX GPS units and use during surfing. Poster presented at the Australian Strength and Conditioning Association Conference, Melbourne, VIC, Australia.


Touch offset models capture users' targeting behaviour patterns across the screen. We present and evaluate the first extension of these models to explicitly address behaviour changes. We focus on user changes in particular: Given only a series of touch/target locations (x, y), our model detects 1) if the user has changed therein, and if so, 2) at which touch. We evaluate our model on smartphone targeting and typing data from the lab (N=28) and field (N=30). The results show that our model can exploit touch targeting sequences to reveal user changes. Our model outperforms existing non-sequence touch offset models and does not require training data. We discuss the model's limitations and ideas for further improvement. We conclude with recommendations for its integration into future touch biometric systems.


The M184V mutation in the HIV‐1 reverse transcriptase gene is primarily associated with rapid, high‐level lamivudine (3TC) resistance. It has also been observed to arise under selective pressure by abacavir, to which it confers low‐level resistance.


During the transformation period of Chinese society,the political connection was the key factor of private enterprises in the city public utilities.This paper selected the first private enterprise which entered the city public transportation as the research subject,and studied the relationship between the changes of political connection and the growth of enterprise.This paper found the source of political connection of an enterprise could be divided into three levels: the support of the key government officials,the political identity of entrepreneurs,and the political identity of top management team members.Political connection of private enterprises was dominant,the support of the key government officials played a decisive role to the growth of enterprises,and the political identity of entrepreneurs and top management team members had no significant impact on enterprise growth.However,the political connection to the growth of the private enterprises was "the double-edged sword",which had the driving effect and the restraining effect.The driving effect lied that political connection would lead to the breakthrough of government regulation barriers and access to government subsidies,which would promote private enterprises to enter the public utilities and growth.The restraining effect lied that political connection might lead to private enterprises unrelated diversification,which increased political risks,thereby inhibited the growth of enterprises.


A fi eld trial was laid out on 11 year old Khasi mandarin trees with 12 different doses organic sources (20, 40, 60, 80 kg each of FYM, pig manure and poultry manure) and three different doses (200, 100, 100; 400, 200, 200; and 600, 400, 400 g NPK / tree ) of inorganic fertilizers to evaluate the effect of different nutrient sources on growth and yield performance of Khasi mandarin. Highest number of fruits per plant was recorded with 600, 400, 400 g NPK application. Plant height (6.96 m), crop canopy (5.7 x 5.6 m) and yield were also highest with full dose of NPK. However, stem diameter (86.8 cm) was highest with the application of 80 kg pig manure. The physico-chemical characteristics of fruits showed that peel weight (32.14 g) and thickness (4.2 mm) were more with full dose application of NPK, while segment weight (87.52 g) and fruit weight (120.4 g) were highest with 80 kg application of FYM. Inorganic fertilizers other than reducing TSS have profound effect on the increase in acidity which in turn reduced the TSS: acid ratio. It can be concluded that 80 kg FYM or 80 kg pig manure application would replenish the depleted nutrients on the khasi mandarin growing soils and maintain soil health.


Since the advent of clinical cytogenetics, the major thrust of research and development has been to achieve greater accuracy of diagnosis. Advances have included banding and high resolution techniques and recently in situ hybridization. In prenatal diagnosis, the need to obtain a speedy result must be weighed against any extra time taken to achieve greater accuracy. Using fetal blood specimens, rapid karyotyping for abnormalities detected on ultrasound has been promoted to aid in the subsequent management of the pregnancy (Nicolaides et al., 1988). Even though these samples are of necessity small, and banding is frequently suboptimal, useful information can be obtained in 2-3 days. Just how accurate does this rapid karyotyping need to be? We present a recent case which centred around this point. Ultrasound at 33 weeks' gestation in the third pregnancy of a 27-year-old woman showed marked polyhydramnios (the deepest verticle pool of amniotic fluid was 11.5 cm) and intrauterine growth retardation. In addition, ultrasound showed an absent stomach bubble, a perimembraneous ventriculo-septa1 defect, and dysmorphic facial features (micrognathia, hypotelorism). Aneuploidy was suspected and 1 ml of fetal blood was collected by cordocentesis. Cytogenetic results were obtained with very good GTG banding from a 48 h synchronized fetal blood lymphocyte culture. The result showed 46 chromosomes with the absence of one normal chromosome 13 and the presence of an additional chromosome, consisting of a translocation between chromosomes 13 and 18. It was not possible with G banding alone to determine the origin of the centromere of this translocation chromosome and hence accurate breakpoints, but it was evident that the karyotype was markedly unbalanced with trisomy for the long


Aim: In order to discuss the ratio of Isolated Systolic Hypertension,Systolic Blood Pressure and Diastolic Blood Pressure and cardiocerebrovascular diseases.Methods: Divided 150 hypertension patients into three groups: 52 Diastolic Blood Pressure patients;15 Isolated Systolic Hypertension patients;54 patients of Systolic Blood Pressure and Diastolic Blood Pressure and cardio-cerebrovascular diseases and had clinical analysis on them.Results: the prognosis of Isolated Systolic Hypertension is good but there's great possibility for the patients who had Isolated Systolic Blood Pressure and Systolic Blood Pressure intercurrent Diastolic Blood Pressure to have cardio-cerebrovascular.Conclusion: To those patients who had Isolated Systolic Blood Pressure and Systolic Blood Pressure intercurrent Diastolic Blood Pressure,we should pay enough attention to them and treated them zealously.


Large-scale diatom communities and diatom complexes of lake sediments researches in the Euro-Arctic region have been carried out. The high efficiency of bioindication of water quality and the state of ecosystems based on diatoms have been shown for the water quality assessment and anthropogenic loads rationing on water resources of high latitudes. Diatom assemblages from lake sediments of different types of aquatic ecosystems reflect the present-day warming of the Arctic climate and the effects of aerotechnogenic pollution. Diatom assemblages of surface (0–1 cm) layers of lake sediments could well serve for the integral assessment of the state of ecosystems and water quality. Diatoms diversity of the Green Belt of Fennoscandia in the territory of the Murmansk region has been investigated.


The performance and the life of the asphalt pavement are severely reduced by the water damage of asphalt pavement.The characteristics and failure mechanism of water damage of asphalt pavement are analyzed.In order to use the scientific method to mitigate water damage of asphalt pavement,measures to enhance the asphalt pavement′s resistance to water damage are summarized and evaluated in three aspects as the raw material,anti-stripping agent and pavement structure.


Therapeutic strategies for targeting cancer stem cells Yu Jeong Kim1#, Elizabeth L. Siegler2#, Natnaree Siriwon3, Pin Wang1,2,3 1Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA. 2Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. 3Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, USA. #Authors contributed equally to this work Correspondence to: Dr. Pin Wang, Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, 3710 McClintock Ave, RTH509, Los Angeles, CA 90089, USA. E-mail: firstname.lastname@example.com The therapeutic limitations of conventional chemotherapeutic drugs present a challenge for cancer therapy; these shortcomings are largely attributed to the ability of cancer cells to repopulate and metastasize after initial therapies. Compelling evidence suggests that cancer stem cells (CSCs) have a crucial impact in current shortcomings of cancer therapy because they are largely responsible for tumor initiation, relapse, metastasis, and chemo-resistance. Thus, a better understanding of the properties and mechanisms underlying CSC resistance to treatments is necessary to improve patient outcomes and survival rates. In this review, the authors characterize and compare different CSC-specific biomarkers that are present in various types of tumors. We further discuss multiple targeting approaches currently in preclinical or clinical testing that show great potential for targeting CSCs. This review discusses numerous strategies to eliminate CSCs by targeting surface biomarkers, regulating CSC-associated oncogenes and signaling pathways, inhibiting drug-efflux pumps involved in drug resistance, modulating the tumor microenvironment and immune system, and applying drug combination therapy using nanomedicine.


Pores are an inherent constituent of concretes. Particularly the part of porosity that connects external surfaces of concrete elements is of research interest because harmful substances will be allowed traveling from one side to the other, or to the main reinforcement. Size distribution of pores (SDP) and the related critical pore size are generally considered important parameters. Further, of course, the process of pore de-percolation during hardening, and the de-percolation threshold could be considered relevant phenomena.