10554 Background: Cancer is the second leading cause of death globally. Early detection will often greatly reduce mortality for many cancers, increase treatment effectiveness, and improve the quality of life for cancer patients, and, by implementing evidence-based prevention strategies, 30–50% of cancers can be prevented. Screening for different cancer types separately is inefficient. A solution is the Integrated Cancer Prevention Center (ICPC), a program with specialists in each discipline who test for multiple cancers during one visit. Methods: This is a prospective cohort study of 17,104 self-referred, asymptomatic patients who visited the Integrative Cancer Prevention Center (ICPC) between January 1, 2006, and December 31, 2019. Clinical, laboratory, and epidemiological data were recorded by multiple specialists. Patients were given follow-up recommendations and diagnoses when appropriate. The primary measure was the detection and staging of new malignant lesions. Secondary measures included cost-benefit and mortality benefit. Results: We screened 8618 men and 8486 women with an average age of 47.11 ± 11.71 years. Of 259 cancers detected through the ICPC, 49 (18.9%) were stage 0, 115 (44.4%) were stage I, 31 (12%) were stage II, 25 (9.7%) were stage III, and 32 (12.4%) were stage IV. Seventeen cancers were missed, only six of which were within the scope of the ICPC, and 189 cancers developed > one year after the last visit to the ICPC. Compared to the stage of detection for cancers in the US, all cancers except for colon were detected at an earlier stage at the ICPC. Lung was the most significant with 86.7% of cancers detected at stage 0, I, or II at the ICPC compared to only 49.3% caught at those stages in the US. Conclusions: This is a proof of concept for a one-stop-shop approach to asymptomatic cancer screening in a multidisciplinary outpatient clinic. It offers evidence that this screening framework can and should be replicated in other healthcare settings and on a national policy level as it saves lives and money. The encouraging results presented here should further the conversation about the utility of screening and add momentum to the movement for increased screening.[Table: see text]


Traffic network assignment under road network vulnerability and traffic congestion has become a hot topic for many researchers in recent years. Starting from the complex network characteristics of urban roads and multi-mode traffic network assignment, this paper establishes a multi-mode bilevel transportation model based on network vulnerability which can better reflect different path choice behaviour in a vulnerable network. The upper level is a function of maximizing the capacity of a road network under the investment constraints of the traffic authorities. Its purpose is to minimize the impact of the network operation efficiency and performance after the links or paths are damaged. The lower level is a multi-mode traffic network equilibrium model, which is essentially a traveler behavior assignment problem. Finally, a numerical example is given to demonstrate the effectiveness of the multimodal traffic model based on vulnerability. The analysis results show that the two-level model considering vulnerability index reduces the impact of abnormal events on the performance of road network, and is conducive to the establishment of a more reliable and stable road network.


In the age of market globalisation, characterised, among other things, by high intensity of competition among enterprises, it is increasingly important to have broadly understood knowledge about consumers, their needs, expectations, habits, aspirations and, above all, determinants of such behaviour. Food manufacturers, in order to survive on the increasingly competitive market of food products, have to monitor factors shaping consumer behaviour on the market, which are subject to constant changes, and to explore the determinants of changes. As part of the research a questionnaire survey was conducted on the population of 200 people – a group of German school pupils aged 12–16. The research procedure was a direct questionnaire survey. The spatial extent of the questionnaire survey was the area of Brandenburg. The substantive scope of the questionnaire survey included issues related with the process of taking decisions by consumers about purchase of particular food products and factors affecting such decisions.


The development of the agricultural sector today is associated a number of problems, core of which is intensity of innovation activity in agriculture, capable of providing accelerated growth of agricultural production. In the article the use of system-adaptive approach to the management of innovation activity agricultural sector is substantiated, which involves timely reaction to the spread of innovation in terms of variability of the environment. Special attention is given to the proposed management model of regional innovative infrastructure "such as overtaking", consisting of a number resource blocks, interacting with each other. The classification of agricultural enterprises on the level of technological support of production is proposed. On the basis of this classification, the spiral model of management of innovation processes in agriculture is refined and supplemented.


There is a need for continued surveillance of diabetes‐related functional disability. In the present study, we examined associations between diabetes, hyperglycemia, and the burden of functional disability in a community‐based population.


Over five decades ago, Lewis' observed that the PR interval could be considered a function of the prior RP, i.e., PR lengthened as P fell closer to the immediately preceding R. Once it was appreciated that the AV conduction time consisted of atrial, AV nodal, and His-Purkinje system components, the relationship described by Lewis was recast in terms of AH being a function of the HA "recovery i n t e r ~ a l " . ~ The empiric graphic plots relating AH to HA (or, equivalently, AV to VA) have been fitted to exponential or hyperbolic functions that have been used with fairly good accuracy to predict beat-to-beat AV nodal conduction times during 1:1 conduction or Wenckebach b l o ~ k . ~ . ~ However, the AV interval can also be modeled as a function of AA, with good experimental agreement.6 Given the algebraic relationship AA = AV + VA, if one of these parameters is held constant, say, AA, any change in one of the remaining two parameters must be accompanied


Based on basic grade watch of students,association rules were mined for distinct courses.Proportion Hypothesis testing was used to verify the generality and availability of the mined-out relation rules.


At the last International Fossil Cycle Chemistry Conference in June 1991, a report was given on the Electric Power Research Institute (EPRI) sponsored project to study and transfer technology on the use of oxygenated feedwater treatment (OT). The report basically summarized the excellent results of employing OT worldwide, and updated the project activities which included development of an EPRI guidance document for implementation of OT in US utilities. Since the OT conversions of Georgia Power`s Wansley Unit No. 1 and Ohio Edison`s Sammis Unit 5 in November 1991, over 30 once-through units have subsequently been converted. In 1994, the first US drum unit was converted. The results have been outstanding with very large reductions of feedwater corrosion products (usually Fe +120 mV) and the change of the surface oxide layer from magnetite to ferric oxide hydrate (FeOOH) throughout the feedwater system. The benefits accrue because FeOOH blocks the pores of original Fe{sub 3}O{sub 4} reducing the transport of oxygen and iron ions through the layer. These surface layers of FeOOH also have a much lower solubility in flowing feedwater. This paper will provide an overview of themore » two supercritical/subcritical unit feedwater treatment technologies, (OT & AVT). In addition, the results of the two EPRI OT demonstration units (Wansley 1, Georgia Power Co. & Sammis 5, Ohio Edison) will be presented.« less


In this work we review Brazilian scientific publications between 2002 and 2012 on School Complaints, in order to critically analyze their main features and the aspects which are associated with generating a school complaint. We developed a systematic search in three bibliographic databases (SCIELO PEPSIC and the Brazilian Digital Library of Theses and Dissertations) using the two key words in Portuguese 'queixa escolar' and 'queixas escolares'. Initially 35 publications were found and, after pre-analysis, 21 papers remained: 13 articles and 8 master's theses. The studies were analyzed, taking their main characteristics and aspects related to generating a School Complaint in account. The results show that the predominating theoretical reference frame in the studies was Socio-historical Psychology and Critical School Psychology, with a dialectic and wide approach of school complaints, considering the historical, socio-cultural, institutional and political-economic dimensions of the social network in which the school complaints emerge.


The present invention is directed to provide a vacuum dryer which offers a short drying time, does not leave stains and does not use isopropyl alcohol (IPA), thereby reducing the risk of fire and eliminating the production of pollutants, and a drying method using the same. As such, there are provided a dryer and a drying method using the same, wherein the dryer comprises: a vacuum chamber that has a dispenser nozzle formed at a cover part thereof and an outlet formed at the bottom for discharging gas therethrough; a stand that is placed within the vacuum chamber and is used as a site for arraying a plurality of wafers or disks thereon; and a punching plate that is placed between the stand and the outlet within the vacuum chamber and has a plurality of holes formed therein.


….it [is] wholly irrational to regard as doubtful matters that are perceived clearly and distinctly by the understanding in its purity, on account of mere prejudices of the senses and hypotheses in which there is an element of the unknown. Descartes, Geometrical Exposition of the Meditations


Objective:To investigate the changes of the probability of inhibition and the mitogen-activated protein kinase phosphatase-1(MKP-1) expression in human breast adenocarcinomal cells of MCF-7 after different concentrations of dexamethasone(DEX) pretreatment and treatment with paclitaxel(PTX).Methods:The viability of MCF-7 cells treated with PTX was detected by MTT assay(mononuclear cell direct cytoxicity assay).The IC50 of PTX was estimated.MCF-7 cells were treated with different concentrations of DEX,and then treated with PTX.The cell viability was detected with MTT assay,and the expression level of MKP-1 mRNA in MCF-7 cells was detected by reverse transcriptase-polymerase chain reaction(RT-PCR).Results:After being pretreated with DEX in different concentrations,MCF-7 cells were induced resistance to PTX.The resistance rate and the expression level of MKP-1 mRNA increased gradually with the increasing concentrations of DEX.Conclusion:With DEX pretreatment,MCF-7 cells were induced resistance to PTX,which may be related to the apoptosis inhibition by MKP-1.


Hyphae and oospores of Lagenidium giganteum Couch were tested for toxicity, infectivity, and irritancy to mice, rats, and rabbits. No infection occurred following exposure to the entomopathogen. Intratracheal instillation of both viable and autoclaved oospores produced a moderate, focal, granulomatous bronchopneumonia, and intraperitoneal injection of viable and autoclaved hyphae produced multiple abscesses in the liver, spleen, and mesentery. Dermal exposure of rats and ocular exposure of rabbits to L. giganteum did not produce significant irritation. Lesions seem to be the result of body reactions to large quantities of foreign material. We conclude that it is unlikely that L. giganteum is infectious or irritating to man or animals.


Modern processors use CAM-based load and store queues (LQ/SQ) to support out-of-order memory scheduling and store-to-load forwarding. However, the LQ and SQ scale poorly for the sizes required for large-window, high-ILP processors. Past research has proposed ways to make the SQ more scalable by reorganizing the CAMs or using non-associative structures. In particular, the store queue index prediction (SQIP) approach allows for load instructions to predict the exact SQ index of a sourcing store and access the SQ in a much simpler and more scalable RAM-based fashion. The reason why SQIP works is that loads that receive data directly from stores will usually receive the data from the same store each time. In our work, we take a slightly different view on the underlying observation used by SQIP: a store that forwards data to a load usually forwards to the same load each time. This subtle change in perspective leads to our "fire-and-forget" (FnF) scheme for load/store scheduling and forwarding that results in the complete elimination of the store queue. The idea is that stores issue out of the reservation stations like regular instructions, and any store that forwards data to a load will use a predicted LQ index to directly write the value to the LQ entry without any associative logic. Any mispredictions/misforwardings are detected by a low-overhead pre-commit re-execution mechanism. Our original goal for FnF was to design a more scalable memory scheduling microarchitecture than the previously proposed approaches without degrading performance. The relative infrequency of store-to-load forwarding, accurate LQ index prediction, and speculative cloaking actually combine to enable FnF to slightly out-perform the competition. Specifically, our simulation results show that our SQ-less fire-and-forget provides a 3.3% speedup over a processor using a conventional fully-associative SQ


Background: Plastic surgery is the problem-solving specialty and getting more technical advances very fast and during wars. Plastic surgery depends on both gross anatomy and minute anatomical and aesthetic units. It interacts with other clinical specialties in the concept of multidisciplinary approaches management of complicated medical and surgical problems. Aim of the work: is to ascertain the knowledge about the scope of plastic, reconstructive and burn surgery specialty in the minds of public, junior doctors and non-plastic surgery specialized doctors. Patient and methods: Questionnaire survey was designed to know what is the scope of plastic surgery specialty in minds of junior fresh graduated doctors, specialized non-plastic surgery-doctors and in minds of random population sample in Egypt and UK. Results: The scope of plastic surgery specialty is limited in minds of general population sample, junior graduated doctors and senior specialized non-plastic surgeons. It was only 32%, 42% and 62-79% orientation, about the scope of plastic surgery specialty in minds of the three studied sectors respectively. Conclusion: Plastic surgery specialty is neither only aesthetic practice nor burn management as it is in the minds of random population, junior doctors and even some specialized non-plastic doctors. Human medical and surgical health problems


vii Acknowledgements ix List of figures xv List of tables xix Chapter 1: INTRODUCTION 1 1.1 Background 1 1.2 Research Problem 3 1.3 Research Objectives 4 1.3.1 Specific objectives 4 1.4 Research Questions 5 1.5 Research Design 5 1.5.1 Data sets 5 1.5.2 Sampling method 5 1.5.3 Statistical method 5 1.6 Conceptual models 6 Chapter 2: LITERATURE REVIEW 11 2.1 Role of temperature to vegetation phenology in Europe .... 11 2.2 Recent changes in the world's climate 13 2.3 Field observation of vegetation phenology in Europe ......... 14 2.4 Remote sensing vegetation phenology 16 xii 2.5 Extraction of phenological metrics 19 2.6 Validation of phenological metrics 22 Chapter 3: STUDY SITES, MATERIALS AND METHODS 25 3.1 Study sites 25 3.2 Materials 25 3.2.1 Gridded surface temperature datasets and analysis ......... 25 3.2.2 GlobCover Land Cover classification v 2.2 product 26 3.2.3 Envisat MTCI time series data 26 3.2.4 Tools/software used 30 3.3 Method 32 3.3.1 Defining anomalous temperature 32 3.3.2 Data cleaning, flagging and gap filling 37 3.3.3 Temporal based information extraction 37 3.3.4 Statistical Analysis 38 Chapter 4: RESULTS AND ANALYSIS 43 4.1 Defining extreme warm seasons in Europe 43 4.2 Data cleaning, flagging and gap filling 43 4.3 Phenology and productivity variables 43 4.3.1 Extreme warm spring events 43 4.3.2 Extreme warm autumn events 44 4.4 Investigating direct and lagged effects 50 4.4.1 Extreme warm spring events: Direct Effect 50


Heterostructures involving transition metal dichalcogenides and other two-dimensional materials such as graphene have a strong potential to be the fundamental building block of many electronic and opto-electronic applications. The integration and scalable fabrication of such heterostructures is of essence in unleashing the potential of such technologies. For the first time, we demonstrate the growth of films as thin as a bilayer MoS2 on monolayer graphene via non-aqueous electrodeposition. Through methods such as scanning electron microscopy, atomic force microscopy, Raman spectroscopy, energy and wavelength dispersive X-ray spectroscopies and X-ray photoelectron spectroscopy, we show that this deposition method can produce large-area MoS2 films with high quality and uniformity over graphene. We reveal the potential of these heterostructures through demonstrating the operation of the structure as a prototype photodetector. These results pave the way towards developing the electrodeposition method for the large-scale growth of heterostructures consisting of varying 2D materials for many applications.


(57) Abstract: external locking clockspring assembly of the present invention includes a housing and a hub rotatably mounted in the housing, housing the first keyhole, the hub has a second keyway ing. In the locked state of the clock spring, the first keyhole is arranged coaxially with the second keyhole. First keyhole, can be inserted key into both the second keyhole are prepared. Key has a flexible tab engageable with the hub. The flexible tab can be bent by the insertion tool, thus the key first keyhole, it is possible to insert into both the second keyhole. Falling out of the key by engagement of the key and the second key hole Metropolitan is prevented, the rotation of the hub relative to the housing is prevented by the engagement of the key and the first keyhole and second keyhole Prefecture.


This study explored how the frequencies and bandwidths of the acoustic resonances of physical tube models of the vocal tract differ when they have hard versus soft walls. For each of 10 tube shapes representing different vowels, two physical models were made: one with rigid plastic walls, and one with soft silicone walls. For all models, the acoustic transfer functions were measured and the bandwidths and frequencies of the first three resonances were determined. For the models with soft walls, the resonance frequencies and bandwidths below 2 kHz were consistently higher than for the models with hard walls. These results confirm the general predictions of mathematical lumped-element models for the mechanical impedance of the vocal tract walls. The resonance bandwidths of the silicone models were well within the range of 50–90 Hz measured for humans, while they were too small for the rigid tubes below 2 kHz.


In humans, disuse is known to result in muscle atrophy and metabolic dysfunction, including reduced mitochondrial content. Previous data from this cohort found that omega-3 polyunsaturated fatty acid (n-3) supplementation attenuated declines in muscle mass, myofibrillar protein synthesis and ADP-stimulated mitochondrial respiration. Disuse has also been shown to increase apoptosis and events linked to autophagy. We investigated the effects of n-3 fatty acid supplementation on content of proteins involved in autophagy, intrinsic apoptosis, mitochondrial fission and fusion and mitochondrial area density during 14 d of immobilization and 14 d of recovery. Twenty females (18-30y) received 20mL doses of n-3 fatty acid (2.97g EPA and 2.03g DHA) or an isoenergetic sunflower oil (oleic acid content: 75%) daily during the 28-d protocol. Biopsies were taken from the vastus lateralis pre-immobilization, post-immobilization, and post-recovery. Protein and mitochondrial content were determined using Western Blot and transmission electron microscopy at 5800X magnification, respectively. Mitochondrial area density (%AD) decreased in the subsarcolemmal (SS, p=0.006) and central intramyofibrillar (IMF) (p=0.001) regions after recovery. The change in the central IMF was driven by a decrease in the n-3 group (p=0.0133). There was no change in the peripheral IMF region. P62 increased during immobilization (p<0.0001) and decreased in recovery (p<0.0001). After immobilization LC3B-I increased in the n-3 group only (p=0.0289). Procaspase-3 content was higher in the n-3 group at all timepoints, D0 (p<0.001), D14 (p<0.0001), D28 (p<0.0001). Procaspase-3 increased after immobilization in the placebo group (p=0.01), and after recovery in the n-3 group (p=0.00807). Procaspase-9 increased during immobilization (p=0.02) and remained elevated through recovery (p=0.00593), with a notable increase in the n-3 group after recovery(p=0.00923). BAX increased in recovery in the n-3 group (p=0.00137) whereas it increased during immobilisation in the placebo group (p=0.02). BCL2 decreased post-recovery (p=0.00671) and the ratio of BCL2:BAX decreased during immobilization (p<0.001) and remained low through recovery (p<0.0001) in the placebo group, whereas the BCL2:BAX ratio decreased post-recovery in the n-3 group (p=0.00712). There was no effect of immobilization or supplementation on OPA1 or FIS1. Our findings show that mitochondrial %AD did not change during immobilization, but decreased in recovery specifically in the SS and central IMF regions of the myocyte. Furthermore, we found that immobilization increased markers of apoptosis and autophagy, but not mitochondrial fusion or fission, and that supplementation attenuated these changes until after recovery. This highlights the importance of considering recovery periods after immobilization and adds to our understanding of how immobilization and n-3 supplementation influence muscle metabolic health. This study was supported with a Canadian Institutes of Health Research Award to S.M. Phillips and a Natural Sciences and Engineering Research Council of Canada Award to M.C Devries This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.


Aim: Psychiatric disorders are common in patients with advanced respiratory diseases. The prevalence of primary spontaneous pneumothorax ranges from 1.2-37 per 100,000 population per year, and the risk of recurrence causes anxiety and depression for the patients.
Material and Method: The Hospital Anxiety and Depression (HAD) scale was applied to 50 patients with a primary spontaneous pneumothorax that underwent treatment in our clinic and a control group of 50 individuals. The study and control group had similar participants (50 patients, 9 women and 41 men). The control group comprised otherways healthy participans aged between 18-40 who had admitted to the smoking cessation clinic.
Results: While the study group's mean age was 25.2, it was 29 in the control group (covariance analysis used for the correction). On anxiety scale, the study group's mean score was calculated as 8.6, while it was 5.7 in the control group. The difference was found to be significantly higher in the patient group. The depression scale score of the study group was 5.8, and the control group's score was 5.7. There was no statistically significant difference between the groups.
Conclusion: Since pneumothorax is a sudden, recurring, and severe illness that can cause respiratory distress, it may lead to anxiety or depression in patients. Without treatment, life-threatening consequences such as dyspnea and cardiac collapse may occur. Furthermore, the painful procedure of tube thoracostomy increases the patients' anxiety. Our objective is to identify potential anxiety-depression in pneumothorax patients, leading to improved mental health outcomes, increased satisfaction, lower readmission rates, and reduced care costs.


The paper analyses the coherence of European regional policy with the aim of territorial cohesion. It argues that to date the Structural Funds have contributed to the delivery of increased territorial cohesion and highlights some critical considerations in relation to the future role of European regional policy in the context of an enlarged Union.


The s imul taneous occurrence of gliomas in the cerebel lum and ce rebrum of the same ind iv idua l is rare. Of the possible mechan isms responsible, t h a t of mul t ip le p r imary tumours aris ing independen t ly has always failed to gain m u c h suppor t . Russel l and R u b i n s t e i n 9 poin ted ou t t h a t this concept would be more acceptable if i t were possible to demons t r a t e mult i focal benign cerebral as t rocytomas , b u t to the i r knowledge th is had never been es tabl ished; in the ma jo r i t y of cases repor ted the t umours were of so m a l i g n a n t a natu re t h a t the deposits could well be metas ta t i c . I n the case we describe a diffuse as t rocyt ic glioma of the ce rebrum and mesencephalon was accompanied b y nodules of glial t u m o u r in each of the cerebel lar hemispheres in a p a t i e n t wi th cut aneous yon Reck l inghausen ' s disease and bi lateral phaeochrome tumours of the adrenal medulla.


From a clinic population of 500 patients with cerebral palsy, 50 consecutive ambulatory adolescents (age‐range 14 to 19 years) were examined for evidence of scoliosis. The group comprised 34 patients with spasticity, four with ataxia and 12 with athetosis. Of these, 19 patients (38 per cent) were found to have scoliosis, 10 of whom were males. None had received any treatment for their scoliosis.


Objective: Oral cancer is a kind of cancer with poor prognosis. In Taiwan, oral cancer is the 6th highest among all cancers in causes of death, and the mortality rate is the 4th highest in male. According to the statistics, the 5-year survival rate haven't been improved significantly during past 20 years. In addition to the clinical examinations, it would be a great help for the treatment and early detection in oral cancer if we find the biological prognostic factors. Tobacco smoke and areca nut could cause DNA damage. A serial DNA repair mechanism would be induced after DNA damaged. These DNA damage signals would be sent to ATM first. After that, ATM will activate other important kinases. CHEK2 is one of the most important checkpoint kinase. CHEK2 could activate other kinases to repair DNA damage. ATM and CHEK2 both could activate TP53, TP53 would induce cell cycle arrest or apoptosis. Our aim is to analyze the relationship between atm-chek2-tp53 genes expression of DNA repair pathway in oral squamous cell carcinoma and relative carcinogenic factors. Material & Methods: We collected 26 pairs of oral squamous cell carcinoma tissue as experimental group and non-cancerous matched tissue as control group from 26 patients who received surgical excision treatment in Kaohsiung Medical University Hospital. We analyze the atm-chek2-tp53 genes expression with qRT-PCR and compare the results with other clinical parameters. Results: Our result showed significant differences of atm and chek2 genes expression between the squamous cell carcinoma tissues and the non-cancerous matched tissues(p < 0.05). atm gene expression also showed a significant difference between with/without areca nut chewing habit(p = 0.0225). atm and chek2 may play an important role in oral squamous cell carcinoma tumorigenesis. In the 61-80 y/o patient group, we found significant down-regulations in chek2 and tp53 gene expression(p < 0.05). The result might suggest that in elder people, impaired DNA repair mechanism correlated with the oral squamous cell carcinoma tumorigenesis. Conclusion: atm and chek2 genes expression showed significant differences between squamous cell carcinoma tissues and non-cancerous matched tissues. atm gene expression also showed a significant difference between with/without areca nut chewing habit. chek2 and tp53 gene showed significant down-regulations in elder patient group which might suggest that DNA repair mechanism is impaired in elder patient. These results uncoverd the pathogenetic pathway of oral cancer. We believe the further investigation of expression of other kinase in DNA repair mechanism would impact the early detection, treatment, prognosis evaluation, and long term follow up in oral cancer.


Background and Aims Nowadays, imbalance is one of the most prevalent problems of the elderly that causes injury, disability, and reduction of independence among the elderly. The present study was conducted to investigate the impact of resistance training methods on dynamic balance, fall risk, and range of motion of ankle in active elderly women. Methods In the current quasi-experimental study, participants were 30 active elderly women (64.79±3.33) in Tehran who were randomly divided into two groups Theraband and weight training. The Y balance test evaluated dynamic balance, fall risk was assessed by the Timed up and Go test (TUG), and a goniometer evaluated ankle range of motion. Statistical analysis of data was conducted using independent and dependent t-tests (in significant level P=0.05) Results Results showed that Theraband training and weight training had a significant effect on fall risk and ankle range of motion Theraband training group was significantly superior to the weight training group in dynamic balance (P=0.001), fall risk (P=0.001), ankle range of motion (left: P=0.004 and right: P=0.001). Also, Theraband training significantly impacted dynamic balance (P=0.012). Conclusion According to the results, Theraband and weight training significantly improve the risk of falls and ankle range of motion in active elderly women. In addition, Theraband training influences dynamic balance positively. In conclusion, Theraband training affects all three research variables more than weight training.


This paper deals with discrete-time Markov jump linear systems (MJLS) whose stochastic process that rules the jumps between the operation modes is non-homogeneous (time-varying transition probabilities). This class of systems is specially useful in networked control system problems where the Markov chain can be associated with time-varying parameters that can be measured or estimated, for example, packet loss variant with distance, network congestion, protocol communication, among others. With this motivation, it is proposed a design procedure for $\mathscr{H}_{\infty}$ state-feedback controllers scheduled by the time-varying probabilities, potentially providing improved performance with respect to the standard robust controllers (in-dependent of the probabilities). Synthesis conditions are given in terms of parameter-dependent linear matrix inequalities (LMIs), that can be numerically solved in terms of polynomial approximations of fixed degrees for the decision variables. As a physically motivated example, it is investigated a problem of car pursuit, where the packet loss rate of control signal varies with time, depending on the distance of the vehicle to the control unit. Additionally, the accuracy of the proposed conditions is evaluated through numerical comparisons with techniques from the literature in the case of homogeneous MJLS (time-invariant probabilities).


This article examines the use of the surgical mesenteric lymph node biopsy in cattle under field conditions. The surgical method and the complications which occurred are described. It is better not to give a sedative to an animal in advanced pregnancy. The site of the incision depended on the stage of pregnancy. In animals in advanced pregnancy in incision should be caudo-ventral in the right-hand flank. To prevent complications, the grid incision should be used then.


Renewable energy sources have gained much attention due to the urge to get clean energy. Among the main options being studied, wind energy is a strong contender because of its reliability thanks to the maturity of the technology and relative cost competitiveness. In order to harvest wind energy more efficiently and to improve safety considerations, the wind turbines blades must be monitored regularly to ensure that they are in good condition. This is even truer in cold climate areas where, because of sub-zero temperatures and humid environment for larger periods of the year, icing represents a significant threat to the performance and durability of wind turbines. Therefore, a structural health monitoring (SHM) system is of primary importance. Recently, there has been a significant interest in employing high frequency radar imagery for Non-Destructive Testing (NDT) and Non-Destructive Evaluation (NDE). The main motivations for using this technology are: it allows penetration of most non-metal and non-polarized materials, it provides the ability for in-depth information, and the millimeter waves pose no health risk to the operator. The main goal of this research is to check the ability of a frequency-modulated continuous-wave (FMCW) radar in performing real-time ice detection onto a glass fibre plate when it works in the frequency band from 57-64 GHz. The technology effectiveness to achieve the aforesaid task is proved in a climatic chamber under controlled humidity and thermal conditions.


The deuteron elastic structure function A(Q{sup 2}) has been extracted in a range of 0.7 {le} Q{sup 2} {le} 6.0 (GeV/c){sup 2} from measurements of elastic electron-deuteron cross section.


The stabilisation of soft clay soils is intended to increase their shear strength and to
reduce their compressibility. The possibility exists of using geophysical methods to
monitor changes in these properties.
Laboratory experiments were carried out on stabilised clays to study the relationships
between shear wave velocity, and hence small strain shear stiffness, and shear strength or
one-dimensional compressibility. One artificial clay, Speswhite kaolin, and two natural
clays, from Malaysia and Sweden, were used as the base clays. Either ordinary Portland
cement or a 1: 1 mix of the cement with unslaked lime was added to the base clays in order
to stabilize them.
In the first part of the investigation, samples of stabilised clay were initially
subjected to a non-destructive bender element test to obtain the shear wave velocity and
then to an unconfined compressive strength test or vane shear strength test. It was evident
that small stabiliser amounts (less than 10 % of the dry weight of the base clay) could
significantly improve both the strength and stiffness of the originally soft material. In
addition, good correlations between the shear strength and the shear wave velocity (or
small strain shear stiffness) of the stabilised clays were established.
In the second part of the investigation, an instrumented oedometer was used to
simultaneously monitor shear wave velocity and one-dimensional compression during tests
on samples cured for a set period. Lateral stresses were also measured. Complementary
tests were conducted in standard oedometers, to study the effect of the curing period. In
these tests yield stresses were identified and corresponded to the onset of changes in shear
wave velocity. After yield, the constrained moduli could be correlated with shear wave
velocity. Tests were also carried out on samples of clay in which a central stabilised
column had been created. Equal strain predictions of the compression of these samples,
based on the results of separate tests on the two components, were relatively successful.
The results of the research suggest that shear wave velocity measurements could be
useful in practice to enable the shear strength and post-yield compressibility of stabilised
clay soil to be estimated.


International healthcare regulators, providers and commissioners are facing severe funding constraints
that are putting increased pressures on quality, innovation and performance.
Within England, NHS resources have unsustainably grown, and all organisations are launching
initiatives to increase quality, innovation, productivity and prevention while decreasing cost. Within
the Swedish case the decentralised organisation of health and care into the countries county councils,
face similar problems. Many are working together to combine new medical and logistical processes
with patient centred approaches.
This paper investigates the political and best practice differences between Sweden and England and
investigates their similarities and differences according to a number of factors, including e.g.
organisational roles, regulator standards, best practices and innovation in quality and organisational
learning tools.
This work is looking to establish a new international best practice framework that structures the
relationship between evidence and design, in its broadest sense. It addresses the international role in
improving design quality of mandatory standards and compliance criteria on the one hand and
excellence and quality on the other.


It is known that the resolution possible from a system based on strongly convergent conical wave fronts is capable of transverse and longitudinal resolution of the order of a wave length. Further, this system ("axicon") should maintain this resolution throughout the region in which the waves converge on an axis. It is, in effect, an imaging device with a very wide aperture and large depth of focus. The latter offers promise for acoustical imaging of certain organs, such as the breast. We have built an axicon designed for a depth of focus of 10 cm, with a convergence half‐angle of 30 degrees. It consisted of a 4‐MHz plane transducer, whose beam was first spread out, then reformed into the conical shape by two axially symmetric, nonspherical mirrors. The system, tested with a fine wire target, gave a beam profile close to theoretical expectation. Wide "skirts" are observed. When used for imaging, it gave the expected resolution, but the skirts gave rise to noise and certain artifacts. The expected depth of ...


models and blanket interventions applied to highly diverse, and dispersed, at-risk populations would help contextualize and underscore the value of her ethnographic cases. But these problems are rather minor and in no way detract from the book's significant ethnographic contribution to understanding human trafficking. This is an important work that should be tremendously useful to students, educators, policy makers, activists, and scholars. While Brennan notes how advocacy can be a form of participant observation, where scholars may occupy dual roles of researcher and activist, her book also demonstrates how participant observation, the foundational method of cultural and social anthropology, can be a form of advocacy.


Pulp and paper mills still pollute our water, air, and soil. This guide explains how mills pollute, gives a vision for a sustainable pulp industry, and shows how British Columbia's "Zero AOX" law can help achieve a pulp and paper industry that sustains the environment, healthy communities, and jobs. This Pulp Pollution Primer explains the basic facts of pulp mill pollution, presents alternatives, and examines industry's resistance to change.


Protein-enriched membrane domains with distinct biophysical properties have been thought as the basic organizing units of cellular membrane. Using particle dynamics simulations, here we study phase separation dynamics and domain formation in binary vesicles. Our simulations clearly show the intimate coupling between domain compositions, lateral domain organization, and vesicle shape transformation. Our simulation results provide insights into the essential role of membrane domains in the coordinated remodeling of cellular membranes and in protein and lipid sorting.


Introduction: Proton pump inhibitors can influence glucose-insulin homeostasis by elevating plasma gastrin. Considering the few clinical trials and contradictory results of previous studies, we aimed to evaluate the effect of omeprazole, a proton pump inhibitor, on glucose-insulin homeostasis in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: In this before-after clinical trial, 40 patients with T2DM received omeprazole treatment for 12 weeks. Patients were asked to continue their diet, lifestyle, and physical activity throughout the study period. Glycosylated hemoglobin (HbA1c), fasting plasma sugar (FBS), insulin level, C-peptide and 2 hours post prandial blood sugar (2hppBS) were measured at baseline and after 12 weeks. Homeostatic model assessment of Insulin resistance (HOMA-IR) and homeostatic model assessment of β-cell dysfunction (HOMA-B) indices were also calculated at baseline and after 12 weeks of omeprazole administration. Results: After 12 weeks of omeprazole administration, there was a clear decrease in the mean HbA1C before (8.11±0.96) and after (7.13±0.68) the treatment (P<0.001). Similarly, a decrease in mean FBS and 2HPPBS before and after treatment was observed, which was statistically significant for FBS (P=0.01) but not for 2HPPBS (P=0.1). There was a clear increase in the level of Insulin (P=0.001) and C-peptide (P=0.003). The mean activity index of HOMA-B before and after receiving omeprazole was 54.41 27.06 and 79.24 45.32, respectively (P=0.007). Also, HOMA-IR index was 5 before, and 6 after receiving omeprazole (P=0.001). Conclusion: Administration of omeprazole, increases insulin levels and decreases the levels of HbA1c, FBS, thus improving glycemic status and can be combined with other drugs used to manage DM, especially in patients with gastrointestinal problems; but more studies are needed.


Abstract 'Will you walk a little faster?' said a whiting to a snail, 'There's a porpoise close behind us, and he's treading on my tail!' (Lewis Carroll)


Reaction of Na(S3N3) with [MCl2(PR3)2](M = Pt, PR3= PMe3, PMe2Ph, PMePh2, PPh3, PEt3, PPrn3, PBun3 or ½Ph2PCH2CH2PPh2; M = Pd, PR3=½Ph2PCH2CH2PPh2) gives complexes of the type [M(S2N2)(PR3)2] in high yield (quantitatively by 31P n.m.r. > 60% isolated). The identity of the complexes was established by 31P n.m.r., i.r., microanalysis and, in the case of [Pt(S2N2)(PMe3)2], by X-ray crystallography.


SUMMARY Applications of nitrogen and a plant growth regulator (mepiquat chloride and ethephon) were used to manipulate stem structure and induce differing degrees of damage due to leaning and lodging in six cultivars of winter barley grown in Belfast, UK, in 1986/87. Weighted incidences of leaning and lodging were combined to give an index indicating damage susceptibility of the cultivars. The index was very high (70) in Pipkin and ranged between 1 and 18 in the other cultivars. Differences between cultivars in number of internodes, plant height and stem weight did not explain their differences in resistance to damage. However, dry weight per unit length ranged from 2·35 and 2·34 mg/mm in the strongest cultivars, Panda and Jennifer, respectively, to 1·75 mg/mm in the weakest cultivar, Pipkin. Nitrogen application increased plant height but did not affect dry weight/main stem, so that dry weight/unit length of stem decreased. The growth regulator treatments reduced plant height and although dry weight/stem did not decrease significantly, dry weight/unit length of stem was similar in treated and untreated plots. Dry weight/unit length has potential as an objective indicator of straw strength in winter barley cultivars and could be used in cultivar evaluation in the absence of damage in field trials.


The geometrical fluctuations such as Oxide Thickness Fluctuations (OTF) and Line Edge Roughness (LER) cause intrinsic statistical variations in the nanoscale FinFET technology. The OTF is primarily caused at a semiconductor/insulator (i.e., Si/SiO2) interface by random roughness of the gate oxide layer. This research work analyzes the effect of oxide roughness on the performance parameters of resistand spacer-defined FinFETs. A large statistical ensemble has been considered to observe the effect of OTF for FinFET devices. Further, all results have been analyzed and compared with the ideal (i.e., rectangular) FinFET. These results reveal that intrinsic parameter fluctuations introduced by OTF become significant for resist-defined FinFET structures. In addition, physical insight for variability-resistant FinFET design has been realized.


The oils extracted from pumpkin seeds have been distinguished as good nutrient vegetable oil. This study aimed to study about the extraction of oils from pumpkin seed oils by Soxhlet method using ethanol as a solvent. The effect of process variables such as temperature, extraction time and particle size were aimed to optimize for maximizing the yield of seeds oil using response surface methodology (RSM). Optimization study showed that the maximum extracted crude oil yield (56.2%) was obtained at extraction temperature of 75 C, extraction time of 270 min and particle size of 0.25 mm. The process model was developed for relation between yield of oils and chosen the independent factors. At optimize condition the extracted oils were subjected to characterization. The interaction effect between different the selected process parameter were also investigated against oil extraction. In addition, the physico-chemical properties of the crude and refined oils obtained at optimum optimal condition were also determined. The FT-IR characterization on the extracted oils showed the presence of functional groups of carbohydrate, carbocyclic, alkane, carbonyl, alkene, aliphatic amine, aromatic, alcohol and methyl ester. The GC-MS characterization of the extracted oils was also investigated for fatty acids composition.


With telecommunications carriers shifting their business focus from voice telephony services to packet-based services for E-mail and Web applications and the provision of high-speed services becoming possible as network speeds increase, there is a need for a mechanism that can facilitate the creation of new services. Although the IP Multimedia Subsystem (IMS) has been attracting attention as an architecture that can separate the call control network from applications and combine voice and packet services, architectures based on industry standards and recommendations like IMS may still have problems, such as insufficient business-oriented functions and poor connectivity with service providers. This paper introduces IMS problems from the network architecture viewpoint and describes a service delivery platform that solves them.


In this paper, we suggest and implement an on-line survey and analysis system based on the database structure. We can do trends analysis in this system and reduce the number of function because we can treat basic algorithms on the database.


Kshara is one of the Ayurvedic modalities used from the ancient period for the treatment of various diseases. Acharya Sushruta who is worshipped as the "Father of Surgery" is the pioneer of Kshara Kalpana. Kshara karma is important among all the "Anushastra karma". It is multifunctional hence advised in several urdhwajatrugata vikaras according to stage and predominance of Doshas. Kshara application is the best one, taking into consideration of its convenience, easy adaptability, cost-effectiveness, and curative. It also has mild postoperative pain, no bleeding, minimum hospitalization and fewer chances of recurrence. The correct way of adopting the procedure has been considered as wealth and a strong weapon in the Ayurvedic pharmacopeia. There is a need of adopting such Para surgical procedures, doing research works, and popularize it in Shalakya practice for effective management and cure of the urdhawavikaras.


This paper mainly studies image design which grey pictures of the traditional culture are applied in modern 2D cartoon. Through Mining and reference in three aspects of Character modeling, the overall attitude, expression means to the shan dong flapping gray pictures, 2D cartoon image design can fo rm style of cartoon image Of romantic exaggeration and sim ple. Image design of cartoon film mulan's organically combi nes style pictures of the shandong grey modeling, and create s a distinctive artistic form and image design work of rich co nnotation of cartoon. Through analysis and reference to the expression means, the article provides a new thought and me thod for the cartoon image design in the future, widen the sp ace of thinking, make modern 2D cartoon image design a ne w direction and breakthrough.


Hungarian electronic journals in medical and health care fields are evaluated. The journals are categorized according to their preliminaries, availability, contents and subject fields. The question of how electronic journals can substitute their printed equivalent is attempted to answer. Based on timeliness, on the versatility of search and retrieval, and on the existence of archives, a substantial risk is involved if a library decides to substitute Hungarian printed publications with electronic journals; however, smart librarians could use the latter for extending existing collections.


games can be interpreted as a type of religious activity that alters a "player's worldviews in radical and unpredictable ways" (206). Beyond the history of the moral panic surrounding D&D, Dangerous Games illustrates the need for the discipline of religious studies to understand the critical role of play in everyday life. Dangerous Games maintains that "both religious worldviews and the worlds of fantasy role-playing games are products of a single faculty through which human beings create meaning together" (180). The realization that a game of the imagination can resemble a religion leads to the suspicion that religion, likewise, could just be an imaginative game. Rather than simply dismissing religion, however, Laycock maintains that we need to "take play more seriously. In particular we should pay attention to the frames of meaning in which these constructed realities occur" (283). As Dangerous Games illustrates, both religion and play utilize the human ability to step outside the known-world and look back on it from an alternative and more idealized reality. Besides having a critical function, these fantasy worlds are not separate from the world of daily life, and by giving meaning to prosaic reality, can lead to the re-enchantment and the sacralization of everyday life.


The announcement of Westpac's exit from advice in late March was dramatic, not just because it signified the last of the big four to exit from wealth, but because of the waves it sent through the broader advice industry.


Plasma heating by launching radio frequency (RF) power in a plasma with antennas is one of the methods used to achieve the necessary temperatures for nuclear fusion. While very successful in heating the plasma, the method is often accompanied by detrimental effects (material release from walls, local overheating of surfaces and changes in edge transport). According to theory, these effects are all consequences of the rectification of an unwanted component of the RF electric field generated by the antenna. Avoiding these effects will be essential in future fusion reactors, but a good description is still lacking. In view of a self-consistent description of the dynamics of a plasma and electromagnetic waves in the presence of metallic objects, a coupling between slow and fast time scale effects will be necessary. Density modifications (on a slow time scale) in front of Radio Frequency (RF) antennas due to rapidly oscillating electric fields have been explained in [1] by means of a ponderomotive force effect. A 1D description of electromagnetic wave propagation (on the fast time scale) in plasmas with varying densities has been given in [2]. We present an extension of [2] to a 2D model. The simulation domain is a rectangular box of dimensions 0.5 m x 1.0 m, which is of the same scale as a RF antenna for heating of fusion plasmas. The actual antenna geometry is not yet taken into account, since this would require a 3D simulation domain and be very demanding on computer power. The antenna is simplified by a current density or electric field excitation. Cold plasma description as formulated by Stix [3] has been assumed for the plasma. For sufficiently high densities, the wave propagation is split into a slow and fast wave branch. Examples with different densities and 2D density gradients are shown, also including lower hybrid and ion cyclotron resonance layers. The evanescence of waves with short wavelengths was found to create numerical difficulties. Slow and fast wave excitations on the antenna will be compared. The orientation between the static magnetic field and the electric field of the waves mixes slow and fast wave effects and influences the electric field pattern in the box. The amplitude of the magnetic field has an influence on the location of the ion cyclotron resonance layer. First steps towards an iterative approach that couples the RF part and plasma response are discussed.


Lysianassoid amphipods collected from various habitats off the coast of New Zealand were examined. A total of seven species were found, representing five genera from three families. Six of these species are new to science. Such a high proportion of new species indicates that the marine amphipod fauna of New Zealand is still quite poorly known. The new species, Ensayara kermadecensis sp. nov., Ensayara ursus sp. nov., Galathella solivagus sp. nov., Hippomedon iugum sp. nov., Hippomedon hurleyi sp. nov. and Tryphosella moana sp. nov., are described in full.


The great drought and, to a lesser extent, acreage adjustment measures, reduced the production of principal farm crops in terms of per-capita figures for the total population of the United States to the lowest level on record (1866-1934). Nevertheless, the Agricultural Adjustment Administration's program, in combination with other factors, brought about a substantial increase in farm income and some improvement in the purchasing power of that part of the 1934 farm income available for family living. The improvement, however, was by no means uniform throughout the country. Farm families increased their purchases of consumption goods to some extent, but many families were so seriously involved in debts that they continued to use as much of the available cash as possible to reduce these pressing obligations. Rural social institutions apparently did not show as much improvement in 1934, because of the usual failure of their incomes to increase as promptly as and proportion to gains in farm incomes, and because of the necessity of meeting debt payments that had prior claim over current expenditures.


The self-help housing stimulant assistance program (BSPS) is an effort by the government to assist the implementation of the construction of decent houses or housing in a healthy and safe environment independently. This program aims to help the community to have a healthy, safe and comfortable home. The purpose of this study was to determine the implementation of the self-help housing stimulant program at the Department of Public Works and Public Housing, Aceh Singkil Regency. The research method used is descriptive-qualitative method, where data collection uses observation and interview techniques in the form of written or spoken words from the people or actors observed. The Aceh Singkil Regency Self-Help Stimulant Housing Assistance Program (BSPS) is running well, but there are some that cannot be overcome in the implementation of the stimulant assistance program, in the sense that this program is almost completely running smoothly.


Yan Bao, Ernst Pöppel, and Yuliya Zaytseva School of Psychological and Cognitive Sciences, Key Laboratory of Machine Perception (Ministry of Education), and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China, Human Science Centre, and Institute of Medical Psychology, Ludwig-Maximilians-University, Munich, Germany, Department of Applied Neurosciences and Brain Imaging, National Institute of Mental Health, Klecany, Czech Republic, Third Faculty of Medicine, Department of Psychiatry and Clinical Psychology, Charles University, Prague, Czech Republic


Primary tumours of the liver are sufficiently rare in the white-skinned races to excite interest, and Cruickshank (1961) estimates their necropsy incidence at 01450% in Great Britain, which corresponds well with that found for Europe as a whole by Berman (1951). Hepatomas, defined as tumours arising from liver parenchyma, are three times commoner in the male, are rarely encountered before the third decade, and predominate in the sixth decade of life. Among the malignant tumours of infancy the disease is relatively common, taking third place after neuroblastomata and renal embryomata (Clatworthy, Boles, and Newton, 1960). It is generally recognized that in Great Britain the majority of hepatomas arise in livers already rendered abnormal, especially by cirrhosis (Parker, 1957) or haemochromatosis (Stewart, 1931). These tumours are almost invariably malignant and curative treatment is seldom possible. They have a low sensitivity to irradiation with x rays or radioisotopes taken up by the liver, such as 32p in the form of chromic phosphate or radioactive gold; their frequent multiplicity throughout the liver often precludes surgical removal. However, surgical extirpation of a hepatoma has been reported by Rosenberg and Ochsner (1948) and subsequently by Lemmer (1950), Henley and Thackray (1951), Otaki, Read, Stubbs, and Sculthorpe (1960), and Gourevitch, Orr, and Whitfield (1957). Although these tumours were either pedunculated or confined to the left lobe of the liver, in the case described by Otaki and his colleagues a right hemi-hepatectomy was successfully performed. The case described in this report is of interest in that a hepatoma occurred in a girl without preexisting liver disease; it was of low malignancy and was successfully removed.


Self-study is realized as a tool for lifelong learning. In order to improve the professional skills of budding engineer, self-study is a component of teaching learning process which helps teacher to monitors the materialization of student activity. The skills that can largely be developed by self-study are communication, critical thinking and practicing modern tools. Activities assigned to the students are (1) Assigning literature to read and apply in their laboratory experimental understanding, (2) read, comprehend and understand the advances in the corresponding field, (3) to demonstrate the concepts taught in class by an experiment (4) get trained and use modern tools for problem solving. The attainments of specific outcomes defined by NBA are designed in such way that it brings desirable change in the student way of learning. Self-study aids the process by measuring various technical and non-technical learning outcomes of student learning. It provides opportunities for students to learn or refine their knowledge of technical concepts traditionally taught in a classroom as well as concepts that are difficult to teach in a classroom setting. Further, it reveals the combination of both teacher-centered and student-centered teaching methods which involves student's activity, gaining and sharing knowledge among the peers. This paper discusses the design, development, implementation of self-study module in the core course of heat transfer in one of the engineering curriculum of BMSCE. It encompasses in-detail discussion on framing of course outcomes, evaluation of different self-study component with rubrics, mapping of CO to PO, improved program outcomes attainment obtained for two consecutive student batches compared with traditional course. The method utilizes data obtained from student marks in internal tests as a means of continuous internal evaluation. This paper discuss the mode of evaluation of selfstudy component, and reasons for the enhanced attainment of CO, PO and hence PSO. The practice of self-study will pave a framework for encompassing cognitive and psychomotor learning outcomes of engineering curriculum.


OBJECTIVES/SPECIFIC AIMS: To introduce CCTS to the clinical and translational research community. METHODS/STUDY POPULATION: Established in the summer of 2017, the Center for Clinical and Translational Science (CCTS) fosters cooperative clinical and translational sciences between the University of Mississippi School of Pharmacy (UMSOP) and the University of Mississippi Medical Center (UMMC). CCTS facilitates the translation of basic research discoveries into clinically validated therapies to improve the health of populations in Mississippi and beyond. Priority areas of investigation in CCTS include Cardiometabolic disorders, Cancer, Neuroscience, Infectious diseases, Precision Medicine, and Community-Based Research. To accomplish CCTS mission three overarching goals have been defined: I) Develop progressive and sustainable capacity for clinical and translational research in Mississippi; II) Promote interprofessional engagement in clinical and translational science; and III) Foster research collaboration among stakeholders in and outside of Mississippi. RESULTS/ANTICIPATED RESULTS: To carry its CCTS's mission three research units have been established: 1) The Pre-clinical Research Unit: Develops processes to move basic science discoveries towards translation into research in humans. This unit provides guidance in the development of Investigational New Drug (IND) applications; and identifies and pursues opportunities to develop progressive capacities for in vitro, ex vivo, in vivo, and in silico approaches for evaluating new pharmaceutical and therapeutic agents. 2) The Clinical Research Unit: Transitions projects that have received IND approval into the first phase of clinical trials. It also transitions clinical trials from Phase I to Phase II and to Phase III; develops standard operating procedures (SOPs), personnel training plans, and policies to guide clinical research; works with industry sponsors and governmental funding agencies; and assures compliance with regulatory requirements. 3) Community/population Research Unit: Develops, coordinates, and facilitates research activities and translation between clinical and community/population research stages. To do so, this unit works closely with community partners and Population Health programs on the Oxford and Jackson campuses. DISCUSSION/SIGNIFICANCE OF IMPACT: Since its inception, the CCTS has surpassed 1.5 million dollars in competitive funding. This early success positions the CCTS well to promote research collaboration between UMSOP and UMMC and to progress in becoming a national leader in clinical and translational investigation.


We herein report our results where the addition of organomagnesium reagents to 2-(1-naphthyl)- and 2-cinnamyl-1,3-oxazolidines occurred consistently in a 1,4-conjugate manner, while lithium, cerium, and copper organometallic reagents added in a 1,2-fashion. The 1,4-conjugate addition pathway was primarily exploited by using (4R)-2-(1-naphthyl)-4-phenyl-1,3-oxazolidine (4) as a substrate to obtain, after NaBH 4 , reduction of the intermediate aldehyde, trans-disubstituted 1,2-dihydronaphthalenes with enantiomeric excesses of 93-94%


The studies of Jiangjuya Petrogram in academic circles mainly concentrated on the fields of archaeology,folklores,religions and arts but its agricultural civilization was dismissed in passing,lacking systematic approach.From the angle of gods worship,weather changes,agricultural production and livestock farming,this article gave a comprehensive explanation and analysis on the agricultural heritage in Jiangjunya Petrogram.Taking the available archaeological data of Jiangjunya Petrogram as a point of penetration and confirming the data with literature mutually,the article investigated the development of agricultural civilization and living conditions in the primitive society in the region of Lianyuangang.The article also discussed the relationship between primitive religion and primitive agriculture for the purposes of exploring the status of prehistoric people's spiritual and material culture in Lianyungang and revealing the relations between persons and the relations between man and nature.


This study aimed to determine the aggression levels of the students studying at schools who admit the students with the Special Talent Exam and evaluate the changes. The universe of the study consisted of the schools who admit the students with the special talent exam, the sample group also consisted of total 413 students including 226 males, 187 females studying at the Faculty of Sport Sciences (SBF) (n=148), the Dilek Sabanci Conservatory (DSK) (n=112) and the Faculty of Fine Arts  (GSF) (n=153). In collection of data, the 7 point Likert Aggression questionnaire by Kiper (1984), for socio-demographical information, personal information forms were used. In our study, the Cronbach alpha value of aggression scale was found to be 0.79. By testing homogeneity and variances of data, the One Way ANOVA for multi comparisons and the Tukey test for the determination of difference resources were utilized while the Independent Sample t test was used for the gender factor in the determination of relevant data changes. The statistically significant differences were found out in the sub-dimensions of Impulsive, Destructive and Passive Aggressions among the students at the Faculty of Sport Sciences and the Dilek Sabanci Conservatory and the Faculty of Fine Arts (P<0.05). In accordance with gender, age and accommodation situations, there were meaningful differences in the aggression sub-dimensions between the schools (P<0.05). Gender-based passive aggression and general aggression differences may be explained with the roles attributed to male and female individuals by society, furthermore, the students at the Faculty of Sport Sciences had higher averages in the aggression sub-dimensions rather than the other school students, which may be related.  Article visualizations:


Ileal pouch–anal anastomosis is a restorative option for patients with ulcerative colitis (UC) requiring surgery. The primary outcome of this study was the relative risk of infertility in women with UC undergoing restorative proctocolectomy (RPC) compared to the same patients before undergoing RPC. Infertility was defined as the inability to conceive after 1 year of regular sexual intercourse without contraception.


The development of designer topological structures is synthetically challenging endeavor. We herein present bispidine as a platform for the design of molecules with various topologies and functions. Bispidine-based acyclic molecule, showing intriguing S-shape topology was discussed. Single crystal X-ray revealed that this molecule exists in solid state as two conformational enantiomers. In addition to that, bispidine-based designer macrocycles were synthesized and investigated for ionophoric properties. Patch clamp experiments revealed that these macrocycles transport non-specifically both anions and cations with at least 10-fold higher chloride conductance over the cations under the given experimental conditions. The results indicated that the self-assembling macrocycle form tubular assembly as evident from ultramicroscopic techniques and single crystal X-ray crystallographic studies. Our design highlights the utilization of non-conventional dihydrogen interactions in nanotube fabrication.


An independent French laboratory (UTAC), specialized in the homologation of new cars, has completed a comparative study between diesel and gasoline engined cars on behalf of LUCAS. This study compares pollutant emissions and fuel consumption. Measurements have been made following European and US standard cycles. One urban and suburban non standard cycle was also simulated on the roller test bench. Test results allow the comparison of the behaviour of both car types for different engine temperatures and ambient temperatures. We can conclude from this study that the diesel engine is a very good compromise regarding pollutant emissions and energy saving. (A) For the covering abstract see IRRD 858138.


In this paper, a novel stochastic geometry-based mathematical model is constructed to examine the performance of a millimeter-wave band joint radar communication (JRC) system. The proposed system comprises two sub-systems: the sensing sub-system, in which radar detects mobile users (MUs), and the communication sub-system, in which directional antennas establish communication with the detected users. Both function-alities operate simultaneously to reduce delay and accelerate beam alignment. The system is modeled under realistic fading channel conditions with distributed scatterers and interferers. Several system parameters are considered in the analytical model, including the density of MUs and clutter from surrounding scatterers, the radar cross section (RCS) fluctuations of the target and clutter, radar search time duration, antenna directivity, and bandwidth. The results reveal that the radar sensing sub-system has the greatest impact on the overall system performance, with radar search duration being a crucial parameter for maximizing the average system throughput.


EDWARD Novitski, 1918–2006, was the acknowledged master of that special art of manipulating chromosomes during what Lucchesi (1994) called "the age of Drosophila chromosome mechanics." Following the Sturtevant tradition, his guiding principle was to derive as much information as possible from breeding experiments with minimum use of direct cytological examination. Nobody could perform this kind of chromosome manipulation as well as Ed and he relished new challenges. (Novitski's closest friends and relatives, especially in later years, called him Eddie, a name he seems to have preferred. Those, such as ourselves, whose acquaintance extends over many years, knew him as Ed, which we shall adopt here.) He continued this kind of work long after the development of microbial and molecular genetics had carried the field in new directions.

Another side of Novitski was a love of pranks and practical jokes, which were indeed clever, sometimes diabolically so. He reached what must be the pinnacle of achievement in this rarified atmosphere, for his reputation was such that pranks that he never carried out were attributed to him nonetheless. He admired Richard Feynman, a physics genius who also enjoyed such things as safe cracking, bongo drums, and practical jokes. Both men took great pleasure in "finding things out" and shared highly creative minds and a love of pranks.

Fortunately, Ed completed an autobiographical memoir not long before his death (Novitski 2005). He was unusual; so, naturally, the book is unusual. It has four main sections. The first is "Fun and Games," a series of anecdotes and practical jokes. The first prank is his most famous, perpetrated on Herschel Roman. Ed manipulated the seminar clock to run slowly so that Herschel, after finishing his talk, seemed to have an embarrassingly long period of time remaining to be filled. His attempts to extricate himself make an amusing story. The second part of Ed's book is the story of his own life. The third is his account of the rift between Alfred Sturtevant and Theodosius Dobzhansky. Novitski had the unique vantage point of having been successively a student of each of them, and he is clearly in Sturtevant's corner. The fourth part is titled "The Pleasure of Finding Things Out." It recounts some of his most interesting intellectual challenges. The book is as idiosyncratic as Ed himself, a mixture of deep science, anecdotes, intellectual depth, and whimsy.


Historically, Vocational Education in Spain has suf fered a situation of political oversight that, unlike other industrialized countri es, it has been conferred a social discredit that is reflected in the lower levels of enrollment in hese teachings, traditionally considered "second class" in comparison to university studies. While it is true, it has been developed in recent decades political initiatives to prestige Vo cational Education. We point out, hence, what these initiatives are and characteristics of t hese teachings which, together with the current economic and social situation have helped t o positively transform their social image and, therefore, have contributed to a significant i ncrease in enrollment. Also, in this paper the results of an investigation is presented that a llow to think that this evolution of the social image of Vocational Education is perceived b y teachers that, as we shall see, consider that it has made good progress in the dign ity of these teachings.


A method, neutron transfer reaction and charge symmetry of mirror nuclei, is used to study (p,γ) reaction on proton‐rich nuclei in this paper. The asymptotic normalization coefficients (ANCs) of virtual decays 9Li → 8Li + n and 27Mg → 26Mg + n were extracted from the angular distributions of the 8Li(d, p)9Li and 26Mg(d, p)27Mg reactions, through distorted wave Born approximation (DWBA) analysis. The astrophysical S‐factors and reaction rates of 8B(p, γ)9C and 26Si(p, γ)27P were then determined based on charge symmetry.


The present study aims to interpret the histological changes observed in surgically excised mitral valves, and to how those changes relate to the clinical criteria of valve failure. A retrospective study was performed on 25 children patients with RHD, who had mitral valve surgery between 2000 and 2004 at the GOTHI hospitals. A highly significant association was present between absence of Aschoff nodules and atrial fibrillation (p=0.0070). Mitral calcification was significantly associated with atrial fibrillation (p=0.0050), followed by double mitral dysfunction (p=0.0142). Valvular endothelial ulcerations were significantly associated with mitral stenosis (p=0.0129) and double mitral dysfunction (p=0.0100). Rheumatic heart disease continues to be an important cardiac problem afflicting the young population of Egypt. The disease has a definite effect on mitral valve microanatomy. Clinical-pathologic correlation is important in evaluating the extent of valvular affection.


PURPOSE: An individually packed absorbent is provided to improve the protection and cleanliness of a product, to immediately detach a strip or a sheet from wings or taps, and to reduce a material for wrapping the product. CONSTITUTION: An absorbent pad(10) is separated form a package. A package material(17) is unfolded by tugging an adhesive tap(20) from an outer side of the package material(17). When tugging side taps(11) from the package material(17), adhesive elements(16) are detached from tap covering members(19) and an adhesive element(15) on a back sheet(14) of the absorbent pad(10) is detached from a central covering strip(18). Accordingly, the central covering strip(18) and a couple of tap covering members(19) remains on the package material(17).


Corporate cultural communication is an important way and tool to promote corporate culture and carry it out. However,it is a relative weak part for corporate cultural research.The article analyzes the implications of corporate cultural communication,and elaborates its diversification,long-term,symbolic,classified,integrated,and open characters,which is helpful for better promoting corporate cultural communication and the implementation of developed one.


The importance of Experiment Design and Data Processing was obvious to all after several decades' development and application.At present,undergraduate and graduate students of chemistry-related specialties in many universities were required to major or minor in this tool course.The teaching reference,teaching content,model of teaching and examination were discussed.The teaching methods of the course were explored to favor stimulating students' enthusiasm and interest in learning,and improving the quality of education.


Location basis variability is a matter of potential concern to livestock producers who contemplate the use of livestock futures contracts as hedging devices and who are removed from a designated futures contract delivery point. Recent attention has been given this problem by Heifner [3] in an analysis of minimum-risk hedging ratios for cattle and hogs, among other commodities, in which measures of risk-shifting effectiveness were generated for comparison among locations. Heifner found no significant differences among locations for either cattle or hogs, indicating that location basis variability is not a significant factor for these commodities. Using a somewhat different approach, and a different set of markets and time frame, the author [1] came to the same conclusion for slaughter hogs in the South. Results obtained for slaughter cattle, however, are somewhat at variance with the findings reported by Heifner. These results and their interpretation are the subject of this paper. The concept of location basis variability is fairly straight-forward. Location basis is the price differential between a local cash market and a futures contract delivery point. Basis variability results from fluctuations in this differential. Hedgers who have access to the delivery market tend to be insulated from its effect by the delivery option and the consequent tendency for cash and futures prices to converge as futures contracts mature. For hedgers in distant markets, however, delivery is not a practical option, so that any difference between the price differential expected at the placement of a hedge and the actual differential experienced upon lifting it causes a deviation in results from those anticipated. Thus, location basis variability can add an increment of risk for the distant hedger, reducing the effectiveness of hedging as a risk-averting device. Location basis variability is not theoretically inherent in the situation of a distant hedger but depends rather on the nature of spatial competition. In perfectly competitive spatial markets, price change will be reflected simultaneously across the spatial price surface, leaving differentials along the surface unchanged. These differentials reflect spatial patterns of supply and demand and transfer and exchange costs. In theory, they change only as these underlying factors change. In the real world, however, leads and lags in price change can occur, and some markets may be isolated from minor price fluctuations that occur in others. In a broad national market such as exists for beef cattle, price differentials tend to be maintained over time, but this does not exclude the possibility of temporary fluctuations which could cause location basis variability to occur. The existence and magnitude of location basis variability is, therefore, an empirical question. While there are a number of ways to measure location basis variability, the method adopted in this study was a direct comparison of hedging revenue variances. If it can be shown that price variances among markets are • not significantly different from one another, then differences in hedging revenue variances between a delivery point market and distant markets can be ascribed to location-related factors. To anticipate a bit, no significant differences in cash market price variances for choice steers were found among the markets studied,but significant differences in hedging revenue variances were found.


The stabilities of aqueous suspension of azo-type ahd anthraquinone-type disperse dyes dispersed with various types of surfactants at high temperature have been examined. The stability highly depends on the ionic nature and chemical structure of surfactants. With ionic surfactants, stable suspensoins are obtained when a surfactant has a polynuclear aromatic ring (or benzene rings more than 2) and a phenolic hydroxyl group in the molecule. With nonionic surfactants, suspensions are stable when a surfactant has benzene rings more than 2 and a cloud point of 2040°C. This suggests that there exists an optimum hydrophilic-lipophilic balance for the suspensions of disperse dyes when they are dispersed with nonionic surfactants. The results have been discussed in connection with the affinity of surfactants for disperse dyes and the difference in change of dissolution state with increasing temperature between ionic and nonionic surfactants.


The Elasticity property/Spring theory indicates that a long lasting spring is always showing small deflection and high stiffness and this property makes it comfortable for any applications. The present investigation deals with a comparative analysis carried out on the basis of sustainability of helical spring that is extensively used in suspension system, to increase the work efficiency of the shock absorber. A suspension system or a shock absorber is a mechanical device that is used to absorb shocks when riding in rough terrains. Stainless Steel grade (AISI316 & AISI302), High Carbon Steel (Music wire grade ASTM A228 & Hard drawn grade ASTM A227) and Alloy Steel (Chrome vanadium grade ASTM A231 & Chrome silicon grade ASTM A401) springs have been utilized throughout the study followed by applying compressive load. In order to enhance the mechanical property of the helical spring, alloy steel based material has been used instead of stainless steel. During this investigation a new shock absorber spring has been designed with the help of Solid Works software and the static structural analysis of the so formed model has been conducted via FEA.


A new feminist field of study has been taking shape within Political Science. Inspired by work in Feminist Political Studies, Policy Sciences, Comparative Public Policy Analysis and Comparative Politics, Feminist Comparative policy seeks to study empirically, theorize, and offer insight into the role of postindustrial states and public policy in promoting and/ or impeding women's status and gender-based hierarchies in public as well as private domains. (1Vlazur1999:483)


The extensive study of the relative merits of various promotion plans presented in the Ninth Yearbook of the Department of Superintendence,' while providing interesting reading material, leaves the question of pupil promotions still in doubt. There is uniform agreement that in small schools the annual promotion plan is advisable, but, when larger school systems are considered, such as exist in cities with populations of one hundred thousand and over, the decision is not clear. As many arguments are presented in favor of semiannual promotions as are presented against this plan. The results of a study recently completed by the writer give evidence that the objections against semiannual promotions, even in larger systems, are becoming increasingly pronounced. Not least among these objections is the fact that the semiannual-promotion plan is responsible for greatly unbalanced classes, depending on whether they are organized in September or January. Thus, Arthur W. Ferguson, superintendent of schools in York, Pennsylvania, declares that in the eight years the plan has been in operation in his city, "6,599 beginners have entered the first grade in September, as opposed to 1,766 entering in January."2 The situation in Hartford, Connecticut, where the semiannual-promotion plan is used, is comparable; the number of elementary-school children enrolled in the September classes during the school year 1931-32 totaled 11,227, while those enrolled in the January classes numbered only 7,764. In other words, 59.1 per cent


OBJECTIVE
The aim: To explore the possibilities of using the WHODAS 2.0 questionnaire in the field of medical and social expertise in Ukraine as an additional tool for the determination of the levels of human functioning in the main spheres of life.

PATIENTS AND METHODS
Materials and methods: A check-up of 125 disabled people was conducted, their scores were determined using the WHODAS as well as their degree of disability according to generally accepted criteria in Ukraine. The study object was the disability level. The study subject - levels of functioning and disability assessment with the WHODAS 2.0.

RESULTS
Results: It is shown that most disabilities occur in the spheres of participation, life activity, and mobility, which is the biggest obstacle to the functioning of such people. An interval gradation of disability level determination is proposed based on the scores obtained by the respondent according to the WHODAS 2.0 with the selection of criteria for mild, moderate, severe, and very severe functional limitations.

CONCLUSION
Conclusions: Correlation analysis of indicators in different sections of the WHODAS 2.0 questionnaire with the disability criteria used in the practice of medical and social examination proves that the disability level assessment according to the WHODAS 2.0 meets the generally accepted criteria, therefore, this disability scale can be an objective tool for functional level assessment and disability group determination.


This work involves designing an antenna that meets the requirements of radar systems. The associated technology, which was for a long time reserved for the military field, is now available in the civil field, as well as in the biomedical sector for the development of "monitoring" systems allowing to monitor the state of health of a patient in a non-invasive way. The goal of this article is to design a wearable textile antenna to detect cancerous tumors of a patient without direct contact with the skin taking into account the electromagnetic waves directed towards the human body due to the difference between the dielectric constants of healthy and unhealthy tissues. Here we present a miniature AMC antenna of rectangular shape that satisfies the UWB characteristics in terms of bandwidth and reflection coefficient. The proposed AMC antenna operates in X-frequency band (8–12 GHz). Using a model of dielectric artificial skin, we have simulated the specific absorption rate on the human body in order to better respect the FCC standards allowed 1.6 W/kg averaged to 1 g of human tissue.


Children all over, particularly in the developing world, are increasingly becoming more and more vulnerable as the poverty rate at the household-level remains high. Children's circumstances are to a great extent dependent on the circumstances of the head of the household. Head of household characteristics, such as employment status, education level, gender, marital status and age among other things, have a direct impact on the children in the household. The paper looks at the relationship between the head of household characteristics and child welfare in the household. The paper uses data collected from households in Boipatong Township in 2013. A child deprivation index was used as a measure of child welfare in the household. A number of questions were used to measure the level of child deprivation. Based on the responses, an index was calculated. An Ordinary Least Squares regression was used to determine the household head characteristics that significantly affect child deprivation. Results from the regression analysis show that there is a significant negative relationship between income and child deprivation. In the sample, the parameter 'age of the head of household' shows that the children are less deprived when the parent in the household is older. The results further show that children from families where the parents are married or living together are less deprived than those from single-parent households. Employment status was also found to be an important attribute. The formally employed parents reduced the likelihood of children being deprived as opposed to the unemployed parents whose children were more likely to be deprived.


The invention relates to an anti-itchy finishing method for a ramie fabric treated by using a united finishing method comprising the following steps of: firstly, carrying out proper dipping treatment on the ramie fabric by using cellulose enzyme treating fluid with the concentration of 1.0-3.0% (o.w.f), and then, carrying out padding or dipping treatment on the ramie fabric by using aqueous polyurethane treating fluid with the concentration of 40-200g/L. The anti-itchy finishing method for the ramie fabric has the beneficial effect that the finishing the ramie fabric by using cellulose enzyme is beneficial to the reduction of fibers crystallinity to achieve the aim of lowering the rigidity and be beneficial to the lowering of the itchy sensation of the fabric; and an elastic polyurethane finishing agent for the ramie fabric can be used for not only covering fuzzy yarns on the surface of the fabric, but also playing a role in enhancing the elasticity of fibers. Particularly, the organization structure of the fabric finished by using the cellulose enzyme becomes more loosen and active after the two optimized processes are united to treating the ramie fabric; in addition, the surfaces of the fibers generate an etching function which is beneficial to the permeation of the elastic polyurethane finishing fluid inside the fibers, so that the elasticity of the fibers is better improved, and furthermore, the aims of reducing the itchy sensation of the ramie fabric and improving the wearability are achieved.


This report concerns the experience at the Children's Hospital of Pittsburgh with 50 children who had skeletal lesions considered to be the result of trauma. The peak age incidence was 3 months. The presenting complaints included disability of an extremity, skin lesions, failure to do well, convulsions, vomiting and diarrhea, and large head. The initial impressions of house officers ranged through the gamut of possible skeletal disorders and blood dyscrasias. Interviews with the parents indicated that the families of these injured children were characterized by parental failure, caused by immaturity, failure to accept responsibility, and other psychosocial afflictions. The seriousness of this disease is indicated by the deaths of five of the infants and the continued injury of others after their return home from the hospital.


This article presents a theoretical model to account for acoustic emission (AE) sensor dynamics in the measurement of head-disk contact/near-contact in magnetic recording system. The AE transducing system is modeled as a linear dynamic system excited by deterministic and random input. The impulse response method and power flow method are applied, respectively, to characterize the system responses. An analytical model is established to describe the dependence of AE output on system transfer functions, filter parameters, excitation forms, contact force, velocity, topographic and mechanical parameters, as well as lubricant thickness.


In order to make the power transmission more stable and ensure the safe operation of the system, a study on the interaction of controllable series compensation and traditional PSS to suppress low-frequency oscillation is proposed. Firstly, the lead-slip angle is adjusted by the lead-lag module of the PSS limit stabilizer to eliminate the reverse modulation phenomenon, and the series compensation is used to optimize the parallel transmission lines and lines of different voltage levels to improve the stability of the long-distance transmission system. Secondly, the phase compensation method is used to set the parameters of the TCSC and PSS damping controllers, the characteristics of the rotor system are judged by the damping ratio, the sensitivity characteristic root is extracted, and the maximum parameters affecting the mode are determined; finally, the genetic algorithm is introduced to coordinate the damping controller to increase the oscillation. Mode damping, constraining the range of each tuning parameter, enabling coordinated optimization. Experiments show that the method in this paper can effectively suppress low-frequency oscillation and ensure the safety and stability of the power system.


The present work deals with the preparation and characterization of Al2O3-SiO2-ZnO composite under mid-temperature conditions via sol-gel method. The structural features of all the samples were assessed by X-ray diffraction (XRD), specific surface area (BET), and scanning electron microscopy (SEM). The changes in the morphology and particle size of the as prepared composites were investigated. Al2O3-SiO2-ZnO composites with different amount of ZnO were prepared. The effect of temperature on the crystallization of Al2O3-SiO2-ZnO composites containing 70% ZnO was investigated. When the calcinations temperature increases up to 850°C, broad peaks of ZnAl2O4 with some impurities of Zn2SiO4 was appeared. From SEM images it was revealed that Naiad structure is formed when the calcinations temperature is 500°C.


Characterization is a key process in attaining high efficiency in state-of-the-art multijunction solar cells. However, the characterization of these devices using methods involving optical excitation and measurements of optical response is challenging and time consuming. For instance the experimental access to information about individual subcells is difficult to attain with common methods. This work will present how the characterization of these devices benefits from the use of electroluminescence spectroscopy (EL). In this study we use a low cost EL set-up -which could be easily integrated in any in-line characterization tool at a manufacturing site-to derive the individual performance of each subcell in the multijunction stack. Using electroluminescence measurements, the external quantum efficiency of each subcell, the current-voltage curve of each subcell and the individual quality factors of each subcell are calculated.


Mobile forensics is crucial in reconstructing various everyday activities accomplished through mobile applications during an investigation. Manual analysis can be tedious, time-consuming, and error-prone. This study introduces an automated tool called Forensic Operations for Recognizing SQLite Content (FORC), specifically designed for Android, to extract Simple Query Language Table Database Lightweight (SQLite) evidence. SQLite is a library that serves as a container for mobile application data, employing a zero-configuration, serverless, self-contained, and transactional SQL database engine. While some SQLite files possess extensions such as .db, .db3, .sqlite, and .sqlit3, others have none. The lack of file extensions may result in missing evidence that could unveil the truth. The proposed tool utilizes both the file extensions and headers of the SQLite data to recognize and identify SQLite data generated or modified by a mobile application. The FORC tool's capability was evaluated using the Chrome application as a case study, and a comparison between FORC and other tools was conducted. The results suggest that FORC significantly simplifies mobile forensic analysis.


Conventional roof lights are not effective in transmitting low elevation sunlight and transmit too much high elevation sunlight, leading to overheating in summer. This paper outlines how light deflecting panels may be used to correct this. The principles of light deflecting panels (laser cut panels, LCP) are presented. Elementary theory to predict the performance of roof lighting systems in sunlight is developed and applied to compare the performance of atria with clear glazing and with LCP glazing. It is shown that the daylighting level at the floor of an atrium can be made nearly uniform throughout the day. Elementary theory of heat transfer in an atrium is developed and used to demonstrate the potential for using LCP to reduce summertime cooling loads in buildings with atria.


During the last 15 years there has been increasing evidence demonstrating that erectile dysfunction (ED) due to vascular etiology is a primary manifestation of endothelial damage and that in a high percentage of the affected men it precedes coronary artery disease (CAD). These findings have positionated ED as a significant risk factor for CAD. The association between these pathological entities relies mainly in an anatomical factor since the diameter of the cavernosal arteries is 1 to 2 mm and of the coronary arteries 3 to 4 mm. Considering that the physiopathology of the endothelial dysfunction is the same in both diseases, the clinical manifestations (DE) become apparent first in the organ with the smaller arteries. Classically the vascular study of the penis has been done with the color doppler ultrasound of the cavernosal arteries associated with an injection of prostaglandin E2; in the clinical setting this study represents a penile stress test (functional study). A pathological result in the color doppler ultrasound of the cavernosal arteries in patients with DE predicts the presence of CAD with high accuracy. Taking this information in account the specific study of these blood vessels may allow the detection of patients in risk of having CAD, positionating this study as a screnning method for patients in cardiovascular risk. SUMMARY


The article treats transition of proper names into common ones. The emphasis is made on the fact that study of connections as well as differences between proper and common names is of great importance in revealing the nature of the proper name.


After reviewing its mechanism of action, the author summarises the action of Primperan in gastro-oesophageal reflux. Various studies have shown that the intravenous or oral administration of a single dose of Primperan induces an increase in the tone of the inferior oesophageal sphincter and an acceleration of gastric emptying in patients with gastro-oesophageal reflux. A dose of at least 10 mg is required. Long term Primperan treatment, at a dose of 40 mg/day in 4 doses, before each meal and at bedtime, significantly reduces the symptoms of gastro-oesophageal reflux and the consumption of antacids.


Laura Parish outlines the BVA's new structure for graduate support, which the Association is rolling out with a pilot of centrally organised Young Vet Network (YVN) meetings.