Background: Cirrhotic Cardiomyopathy (CCM) means cardiovascular fragility in cases of cirrhosis of the liver, when the perceived heart disease does not occur. Methods: Cases through liver cirrhosis remained enlisted from OPD hospital of Sir Ganga Ram Hospital Lahore from April 2017 to May 2018. Ordinary set additionally identified cases of liver cirrhosis that were rejected by a perceived heart disease before the hepatocellular carcinoma remained hired for logical comment explore. Cases about DM, hypertension remained excepted. Absolute worldwide longitudinal stress, one-point carotid shock wave velocity, with the various obstacles limited in inactive position. Results: Here, 34 candidates remained in the standard set, plus 95 cases in the liver cirrhosis set. 29.6% of the cirrhotic cases offered by standard systolic through and through sporadic diastolic purposes were offered, moreover QTc sequel, which remained unchanged by CCM. 36.4% of cirrhotic cases consisting of diastolic fractures in the inactive partner state to 23.4% in the controller set. Systolic purposes showed no obvious difference between cirrhosis, which is also common, nor between repaid decompensated cirrhosis, not one or the other. One-point PWV also remained seriously advanced in cirrhosis than in the usual amount and developed further in CCM than in non-CCM cases. One-point PWV predicted CCM additionally diastolic fractures in cirrhosis. Most strikingly, their value > 1382 cm/s represents the general humanities in decompensated cirrhosis and contributes precisely to the CTP score in HCV-related cirrhotic cases (AUC = 0.817). Conclusions: In cases of cirrhosis, 26.7% were characterized by CCM by inert cardiovascular restrictions. One-point PWV prolonged in CCM, associated by diastolic fractures. This is comparable to general death in cases of hepatitis C infection associated with decompensated cirrhosis. Additional research may be required to confirm their suitability for CV estimation, which means more demise risks in HCV-associated decompensated cirrhotic cases.


We present here results of temperature dependent high resolution synchrotron x-ray powder diffraction study of sequence of phase transitions in Ni2MnGa. Our results show that the incommensurate martensite phase results from the incommensurate premartensite phase, and not from the austenite phase assumed in the adaptive phase model. The premartensite phase transforms to the martensite phase through a first order phase transition with coexistence of the two phases in a broad temperature interval (~40K), discontinuous change in the unit cell volume as also in the modulation wave vector across the transition temperature and considerable thermal hysteresis in the characteristic transition temperatures. The temperature variation of the modulation wave vector q shows smooth analytic behaviour with no evidence for any devilish plateau corresponding to an intermediate or ground state commensurate lock-in phases. The existence of the incommensurate 7M like modulated structure down to 5K suggests that the incommensurate 7M like modulation is the ground state of Ni2MnGa and not the Bain distorted tetragonal L10 phase or any other lock-in phase with a commensurate modulation. These findings can be explained within the framework of the soft phonon model.


The article presents the principles of postal operator's liability for nonperformance or inadequate performance of postal services concerning the carriage of goods. The analysis of regulations of the Postal Law Act was made with reference to the Transport Law Act, which is the basic legal act concerning transport of goods in domestic traffic. The author indicates similarities and discrepancies between these regulations. In conclusion, the author states that it is necessary to strive for unification of the regulation concerning carrier's and postal operator's liability for damage in the transported goods.


Nanotechnology had certainly become one of the most promising emerging technologies in the twenty - first century,offering profound potentials in addressing a wide range of challenges in medical world.The application of nanotechnology in biological research presents great opportunities in tackling tumor with novel properties and functions,developing into an increasingly more important tool than Radiotherapy and Chemotherapy.In this article,we introduced the notion of Nanoparticle targeted therapy in tumor studies and elaborate the latest advancement of the system of Nanomaterials as vehicles for target drug system which explores nanotechnology in the search for effective tumor targeted drugs.


The changing environment of public finance is such that greater use of self-funding and financial independence will be required of public facilities and municipal services. Traditionally, the design of user fees has been approached from the viewpoint of cost recovery. The very rigor and cost of this method impedes its use in state and local governments which comprise a multitude of small systems. An alternative approach, a market orientation, is proposed. Rates and rate structures can be set from comparative data and citizen input through a public/private partnership. The market approach also affects management philosophy and organization--driving the public works function toward a consumer rather than ward orientation, toward modern billing and debt collection methods, and toward the revenue center as an innovative structure.


EDA (Electronic Design Automation) is the hotspot of the development of electronic technology, the corresponding course gradually become an important application courses in the electronic engineering. The teaching strategy of this course is a very important part, whereas the traditional teaching mode has not been able to fully adapt to the application of flipped classroom. According to the characteristics of flipped classroom, teachers construct learning resources such as websites, videos and online tests. Students can learn the knowledge out of class. It puts more of the responsibility for learning on the shoulders of students. At the same time, through the development of micro experiment platform makes the students can begin the hands-on exercises at the very beginning to consolidate what they have learned. The experiment time it also increased, the students' participation is improved. The teaching effects also become


Traditionally, development geologists have been responsible for studying leases, logs, and cores in detail in support of engineering functions. These responsibilities have grown from defining gross reservoir geometries to understanding subtle differences in reservoirs attributed to stratigraphic and structural complexities, depositional environments, and hydrodynamic processes. To handle these increased responsibilities, expertise has become essential in the areas of computer applications, log analysis, modeling, and management of produced water. Examples of the use and application of each area to projects from fields on the west side of the San Joaquin Valley demonstrate current techniques employed by development geologists and the evolution of a development department within Texaco. A study of a property in the South Belridge field on which 330 wells were drilled over a two-year period illustrates how computer resources have become vital in handling the vast amount of data needed to perform detailed geologic studies. Intricate geologic characterization has become essential to optimizing and defining reservoir performance in several fields: (1) Southeast Lost Hills, a complex diagenetic trap; (2) Buena Vista Hills, where log analysis is needed to make reserve estimates and step-out potential meaningful; (3) Midway-Sunset field, for which detailed geology leads to new field-wide models and futuremore » prospects. Increasing environmental concern over waste disposal has required an important involvement of development geologists in the geologic and hydrologic aspects of subsurface injection of produced water and other brines in the Santiago Creek field. Instead of providing a training ground for future explorationists, development geology should be viewed as an alternative career with potential for a much greater demand in the future.« less


This paper investigated the security of a chaotic block cipher. Found that the firstly several chaotic states generated by this cipher were not sensitive to the initial state and parameter. Under the chosen plaintexts condition, proposed a divide-and-conquer attack on the equivalent key. The length of key is 106 bit, and the computing and memory complexity of the attack are about 2 60 and 2 50 respectively. The success rate is 0.928 4.


This research aims to examine the factors that influence the librarian's
satisfactory about automation system through the approach of Technology
Acceptance Model. This research is to adopted from research model TAM Davis
1989. There are two variables in this research, are independent variable that containt
like ease, expediency, trends, real, conditions and the dependent variable is like the
satisfaction of librarian. The data collection methods that used by questionnaire as the
first method and interviews, documentation is as a complement. The population in
this research is all of the librarian in Christian Duta Wacana University at Yogyakarta
on February 2013. The samples that taken are from 93 respondents using accidental
sampling technics. The data analysis that used is descriptive quantitatif. The result of
this research mention that the easier variabel, the advantages the tendencies, the real
affect that influence the variable of librarian satisfactory. The variables of advantages,
tendencies, real affect is described became 14 indicator, there are 6 easier indicator, 4
advantages indicator, 2 tendecies indicator, 2 real condition indicator.But to variable
of satisfaction is devided into 3 sub variables respon, focus, respon time and the
indicator it self have sub indicator like this 3 respon indicator, 3 focus indicator and 2
respon time indicator. The result of this research is the criterion based on all average
scores that find from the result of variable easier, advantages, tendencies, real
condition is 2,97, the librarian satisfactory is 2,78). So it can be categorized that the
librarian satisfactory about automation system by technology acceptance model
approach in Christian Duta Wacana University at Yogyakarta have a get good
categorized.

Keyword : Automation System, Technology Acceptance Model, Librarian Satisfactory


The solubilities of o-chlorobenzoic acid, p-chlorobenzoic acid, o-nitroaniline, and p-nitroaniline in dimethylformamide (DMF) + water at different compositions are reported at 303 K. At this temperature, p-chlorobenzoic acid is more soluble than o-chlorobenzoic acid in DMF + water with the difference in solubilities increasing with the DMF content. For the nitroanilines, however, o-nitroaniline is more soluble than p-nitroaniline in DMF + water.


In active control, the control force execution time delay cannot be avoided or eliminated even with present technology, which can be critical to the performance of the control system. This paper investigates the influence of time delay on the stability of an SDOF system with an optimal direct output feedback controlled mass damper. An active mass damper system can take the form of a hybrid mass damper (HMD) or a fully active mass damper (AMD) depending upon imposed design constraints resulting from space, strength and power limitations. Explicit formulas and numerical solutions to determine the maximum delay time which causes onset of system instability are obtained. The control effect of the two‐DOF HMD/AMD benchmark system with and without time delay is illustrated quantitatively in a continuous‐time approach. In order to fit the digital implementation of the computer‐controlled system in practice, the control gains will be compensated by using their discrete‐time version to overcome the degradation of control effect due to time delay. Copyright © 2001 John Wiley & Sons, Ltd.


Abstract The hydrogen-carbonate ion [(HCO3)-] has been detected by Fourier transform infrared (FTIR) spectroscopy in the c-axis structural channel of Na-bearing type A-B carbonate apatite synthesized under conditions of high P (0.1-1 GPa), T (800-1350 °C), and p(CO2), and accounts for up to one-third of the total complement of channel carbonate. The hydrogen-carbonate ion is only loosely bound in the apatite channel, and breaks down on aging at room temperature. Volatile decomposition products are lost from the carbonate apatite structure, with CO2 more mobile than H2O. The mobility of small volatile molecules points to a possible role for the apatite channel in mediating acid-base reactions in restricted surficial environments and biological systems.


MSC51 microcontroller solve the access data storage capacity of capacity constraints,in large measure to extend and improve the overall function of SCM applications.Articles by Samsung NAND flash memory chips-K9K2GXXU0M,for example,extends the AT89C51 chip data memory,to achieve a single chip mass storage system.


The ISPAD Position Statement on Type 1 Diabetes in Schools is based upon the 2018 ISPAD Clinical Guidelines for Management of Type 1 Diabetes in School and draws upon the published position statements on diabetes in schools of many countries. The input from less-resourced communities in Ghana, Pakistan, Haiti, Ecuador, Bolivia, and India is acknowledged and appreciated. The authors also acknowledge the input of parents, adolescents living with type 1 diabetes, school personnel, and experienced health care professionals who have contributed ideas and clarification of roles. The principles of this ISPAD Position Statement on Type 1 Diabetes in Schools should be applicable globally. ISPAD strongly supports compliance with legal protections for children and adolescents with type 1 diabetes to attend school, to be safe at school, and to receive optimal medical management at school and in all school-associated activities. Note:


This study examines how four university-based literary scholars in the United States read literary texts. Findings suggest that the scholars used four related literary literacy orientations in their reading: They attended to their affective experiences with literature, built recursive interpretations of literature, contextualized literature, and recognized and managed literary complexity. As broad-level disciplinary ways of navigating literature, these literary literacy orientations included the scholars' meaning-making practices as well as their beliefs, feelings, and attitudes about literature and making sense of it. Findings support and


Today, the increasing number of women entrepreneurs adopting ICTs has grown their businesses and made them more efficient. This study empirically analysed the practice of women's entrepreneurship and its relation to the adoption of Covid-19 Pandemic ICT among SMEs in West Sumatra. A quantitative approach was used to empirically prove the connection between women's entrepreneurship and the use of ICT among SMEs. The population of this study consisted of female SMEs listed in the Cooperative and SME's Office of West Sumatra Province. A random sampling technique with a simple random type was used to select respondents. Questionnaires were distributed to 210 respondents to collect data and other related information. The results of this study proved that there is an effect of women's entrepreneurship practices on ICT adoption among SMEs in West Sumatra. Several aspects of women's entrepreneurship practices, such as customers, education and training, skills, internal support (including culture, social structure, religion, and family), and external environments (including governmental and associated institutions), contributed to women's entrepreneurship. Overall, this research contributes to the empowerment of women by providing them with equal opportunities to learn, improve their abilities, and work in business professions as technology-based innovation entrepreneurs, similar to men.


Background: Emergency Department overcrowding remains a significant problem. Interventions have often focused on areas external to the ED, with patient flow in the ED receiving less attention. Efforts to address ED flow are complicated by daily fluctuations in patient volume and acuity. Our local protocol brings in additional physicians when internal metrics indicate patient demand can't be met by current physician resources (a 'surge' period). However, anecdotal evidence suggests a lack of satisfaction and efficacy. We therefore undertook a project to improve our local management of these surge periods. Aim Statement: To improve the effectiveness of an ED Physician Surge Protocol to allow for a physician scheduling strategy that is reflective of the needs of the ED. Measures & Design: This project consists of 3 phases. Phase 1 was an analysis of current surge metrics (including frequency, temporal patterns and physician response), with concurrent literature search to identify any best practices or easily addressable protocol changes, with first planned PDSA cycle. Phase 2 is a mixed methods survey of local staff to identify barriers and enablers of our current protocol, concurrent with a national survey of current practices. Phase 3 will be the implementation of a revised protocol, followed by a second mixed methods survey and analysis of metrics of interest. Evaluation/Results: Analysis of surge data (Oct 2018-Oct 2019) demonstrated a high volume of surges per month (78.7 +/- 10.9), highest at Foothills Medical Centre (94.3). Across all sites, afternoon periods had highest frequency of surges (absolute peak 1400 - 1500) with a secondary peak 2200–2300, both peaks occurring most frequently on weekends (Fri-Sun) However, physician response to surge calls was < 10% (5.8-9.1%), with no discernable temporal pattern, even accounting for the significant number of automatic surge calls cancelled by clinicians. Analysis of data, in addition to literature review and engagement with senior administration suggested no immediate protocol changes, therefore project moved to 2nd phase. This phase is currently in progress, with planned analysis using Pareto Chart methodology. Discussion/Impact: Our initial data clearly demonstrates that current procedures are inadequate to address this ongoing issue, with no readily apparent solutions. Analysis of local barriers and enablers is currently underway, in addition to a national survey, with the results expected to inform an extensive redesign of current procedures.


A first super-resolution enlarger 103 works on moving pictures input with a standard resolution, implementing a process for a super-resolution enlargement including information on frequency components in the spatial direction and the temporal direction that has been potentially contained in the input moving pictures but unable to express to a sufficient degree by the standard resolution, and provides super-resolution enlarged signals, which are returned to the standard resolution at a first resolution converter 104, and the super-resolution enlarged signals as returned to the standard resolution are encoded at a second encoder 107. There is a first encoder 102 for encoding moving pictures input with the standard resolution, and a multiplexer 109 working to multiplex a sequence of encoded bits from the first encoder 102, a sequence of encoded bits from the second encoder 107, and the like. The second encoder 107 is adaptive to employ local decoded signals in the first encoder 102 or processed signals thereof, as reference signals.


Some white natural fillers (kaolin and talc) and synthetic mineral ones (precipitated silica, sodium-aluminium silicate, zinc silicate, calcium silicate) together with waste materials (cement dusts and post-fluor silicas) were subjected to surface modification and characterised. Various types of silane coupling agents (amino-, mercapto-, methacryloxy- and ureidosilanes) were used for surface modification. The modified fillers were mixed with butadiene-styrene rubber, polyurethane and PVC. Good physico-mechanical properties were obtained for PVC containing talcs and kaolins modified with methacryloxy– and ureidosilanes. The strength of polyurethanes was increased most by modification of the fillers with mercapto- and aminosilanes.


For hundreds of years, employers have searched for an answer to a common managerial question "How do I get the most from my employees?" Research efforts to answer this question have resulted in a patchwork of motivation theory and research. One predominant piece of that patchwork was proposed by Adams in 1963 when he offered equity theory to explain what happens in the workplace. In simple terms, equity theory states that an employee compares what he or she puts into a situation and gets out of a situation to those inputs and outcomes of a referent other. An individual wants to see equity between his outcomes/inputs to the ratio of outcomes/inputs of a referent other. When there is a lack of equity, the individual experiences discomfort and seeks to establish equity. Huseman et al. (1985, 1987) proposed equity sensitivity theory as an extension of Adams' (1963, 1965) equity theory to account for individual differences in response to perceived inequities in work situations. According to King et al. (1993), equity sensitivity theory asserts that individuals respond to situations of inequity as "benevolents" (tolerant of unfavorable inequity--situations in which one's own outcome/input ratio is less than a comparison other's ratio), "equity sensitives" (classic equity preference--situations in which one's own outcome/input ratio is equal to a comparison other's ratio), or "entitleds" (tolerant of favorable inequity--situations in which one's own outcome/ input ratio is greater than a comparison other's ratio). Moreover, King et al. (1993) suggest that benevolents are more focused on the inputs they contribute, while entitleds are more focused on the outcomes they receive. These differences are critical to our understanding of business relationships and transactions because of the potentially substantial impact of equity perceptions on other important variables such as justice, job satisfaction, commitment, organizational citizenship behavior, turnover, and other individual and organizational factors. Understanding the differential influences of benevolent, equity sensitive, and entitled responses to perceived inequities may provide important insights into any number of variables that are central to our understanding of workplace behavior. Virtually all of the equity sensitivity research to date has used the Equity Sensitivity Instrument (ESI) developed by Huseman et al. (1985). The scale contains five pairs of statements, and respondents are asked to allocate ten points between the two statements for each pair. Points are then summed for the statements that reflect a "benevolent" point of view. Despite its widespread use, criticisms of the ESI persist. Sauley and Bedeian (2000) discussed problems related to item development, sample-specific scoring, and inappropriate use of cut scores to determine categories. Foote and Harmon (2006) suggested adding equity sensitive items to the ESI so that points could be distributed over three responses (i.e., benevolent, equity sensitive, and entitled) rather than the two current responses (benevolent and entitled). Davison and Bing expressed concern with the forced-distribution format of the ESI, noting that "benevolence and entitlement will always be perfectly negatively correlated in this measurement system," (2008:132) and Shore and Strauss (2008) found low convergent validity between the ESI and conceptually similar constructs. A few researchers have considered the input side of the equity equation (Tornow, 1971; Larwood et al., 1979), but the majority of equity sensitivity studies have focused on the outcomes individuals' receive (e.g. Miles et al., 1991; Allen and White, 2002; Shore, 2004). Recently, Davison and Bing (2008) further reconceptualized equity sensitivity as a multidimensional construct based on the extent to which individuals focus on inputs and/or outcomes. They envisioned benevolence and entitlement as separate dimensions, such that an individual could exhibit a low or high focus on inputs (benevolence) and a low or high focus on outcomes (entitlement). …


We jointly estimate and test a conditional asset pricing model which includes long term interest rate risk as a potentially priced factor for four broad classes of assets - large stocks, small stocks, long term Treasury bonds and corporate bonds. We find that the premium for long bond risk is the main component of the risk premiums of Treasury bond and corporate bond portfolios, while it represents a small fraction of total risk premiums for equities. Our results suggest that investors perceive stocks as hedges against variations in the investment opportunity set. Since these four asset classes represent some of the most important for investors, we proceed to use our estimates to compute the optimal period by period asset allocations for investors with different risk preferences and trading strategies. We decompose the trades in their market timing, hedging and speculative components.


Condensed tannins can reduce methane emissions coming from the ruminal fermentation of forage. The aim of the study was to evaluate the effect of forage conservation (hay vs. fresh) and the inclusion of condensed tannins [CT, 10% of Quebracho (Schinopsis Balansae) with 75% of CT] in the concentrate (Con trol vs. CT) on in vitro gas and methane production and the ruminal degradability of organic matter (IVOMD) at 24 h. The diets contained 70% forage and 30% concentrate. Gas production (ml/g organic matter (OM)) was not affected by the forage conservation or tannin inclusion in the concentrate (P>0.05). Regarding the kinetic parameters of gas production, the asymptotic gas production was similar in both forages, but the gas production rate was greater in pasture than in hay (P<0.001). The kinetic parameters were not affected by tannin inclusion. Methane production (ml/g OM) was affected by the interaction between the forage conservation and concentrate (P<0.01). Methane production decreased by 20.5% when tannin was included in the hay diet but did not change in the pasture diet (P>0.05). The IVOMD was only affected by the forage conservation in the diet, being greater for the diet with fresh vs. hay pasture (74.1% and 61.6%, respectively; P<0.001). In conclusion, the use of concentrate with condensed tannins in ewes' diets reduced methane production in diets containing hay but not in those based on pasture. Gas production and IVOMD were unaffected by the inclusion of condensed tannins in the diet, regardless of the conservation of forage


The health benefits of oligosaccharides should be accurately offered to the consumer based on scientific evidence. In particular, the prebiotic effect of nondigestible oligosaccharide is concerned with the digestibility and fermentability in the gastrointestinal tract. Since galactosylsucrose is resistant to the digestion in the gastrointestinal tract, it is widely used as a prebiotic. But, it is still unknown whether it is partially hydrolyzed by small intestinal enzymes. This is the first report that galactosylsucrose is slowly hydrolyzed by human small intestinal enzymes. The present study investigated the hydrolysis of galactosylsucrose using human and rat small intestinal enzymes. Galactosylsucrose was slowly hydrolyzed by small intestinal enzymes from both humans and rats, although the hydrolyzing activity was lower than that for lactose. Galactose, which is bonded via a β-4, 1 linkage to the glucose residue of sucrose, was the first moiety to be released from galactosylsucrose; this increased linearly during the incubation. Glucose and fructose produced from sucrose (which is the hydrolyzed residue of galactosylsucrose) also increased linearly after a delay during the early period of incubation. These results suggest that initially lactase attacks the lactose unit of galactosylsucrose, and sucrase then hydrolyzes the resulting sucrose unit. Thus, hydrolysis of galactosylsucrose starts from the β-4,1-linkage between galactose and glucose at the non-reducing terminal.


The flow field characteristics of three different geometries of square jets in a crossflow at various blowing ratios are examined. The geometries considered are: perpendicular, streamwise-inclined, and spanwise-inclined jets. The inclined jets are at a 30 deg angle to the wind tunnel floor. Mean velocity and turbulence measurements along with film cooling effectiveness and scalar transport data were obtained. Jet-to-crossflow blowing ratios of 1.5, 1.0 and 0.5 are used with a density ratio of 1. It is shown that the flow field at the jet exit is strongly influenced by the crossflow as well as by the inlet conditions at the entrance to the jet orifice. The strong streamline curvature which is present in the perpendicular and spanwise injection cases appears to result in the greatest turbulence anisotropy. The film cooling effectiveness is best at the lowest blowing ratios as the jet is deflected strongly towards the floor of the wind tunnel, although the improvement is more significant for the streamwise injection case


This study analyzed the moderating role of future career expectations and efficacy beliefs in employees' responses to unmet career expectations by drawing on the premises of agentic approach in soc...


(57) Abstract: In this example, the aromatic compound having at least one oxidizable substituent group attached directly to an aromatic ring carbon atom of the corresponding production of aromatic monocarboxylic acids and / or polycarboxylic acids It describes a novel method carried out by subjecting the catalytic oxidation in homogeneous phase. This method, the packed tower 200 is fed into the packed column bed of material exhibiting high adsorption force with respect to poly oxide hafnium and / or zirconium the crude product obtained as a result of the oxidation stage is in 300 ℃ include purification steps to operate at a pressure of 90barg from temperature and 30.


iNEMI has an ongoing Low Temperature Solders Process and Reliability (LTSPR) Project with the goal of developing low temperature BiSn solder pastes for use in assembling board products within the consumer computer industry. As part of the Mechanical Shock Reliability Assessment phase of this project, heterogeneous, mixed SAC-BiSn alloy solder joints as well as homogeneous BiSn alloy solder joints of the 14mm x 14mm CABGA192 daisy-chained component were subjected to multiple shock drops. The Test Vehicle board and Shock Testing conditions were as specified in the JEDEC JESD- B111A standard. There were four component land sites on this board, two lands of a Solder Mask Defined (SMD) design and two of a Metal Defined (MD) design. The top two performing low temperature ductile metallurgy solder pastes from previous project evaluations were chosen for evaluation for this leg using a 14 x 14mm CABGA192 package assembled on an OSP board surface finish. Homogeneous SAC solder joints, formed by using a generic SAC305 solder paste, was also tested for comparison. In-situ monitoring of the component-to-board daisy chains was used to document component failure and a Weibull analysis was completed based on these failures to compare the performance of mixed and homogeneous solder joints formed with various solder pastes. In addition, failure analysis based on cross-sections and fracture surfaces produced by the Dye-and-Pull methodology was performed to understand the extent of Bi mixing, solder joint height effects, failure modes and locations of the cracks for the different combinations. The Weibull plots and failure interfaces observed were disparate for the two types of component sites with different land patterns. The Weibull analysis showed that for solder joints assembled on MD lands, three of the four LTS Bi-Sn solder joints performed 28-44% better than the SAC leg, However, one of the heterogeneous, mixed BiSn-SAC solder joint legs on MD pads exhibited the lowest characteristic life of all legs tested. Most failures for the SMD pattern component sites were very close to the solder joint to PCB land interface, whereas failures for the MD land patterns were exclusively in the laminate under the PCB lands.


The carboamination reaction can be considered an important and fascinating tool for atom-economic and convergent construction toward the functionalized N-containing cyclic compounds. Because the aza-cycle is frequently found in almost all members of the alkaloid family with immense synthetic and pharmacological activities, the formation of this ring system is a highly demanding task for synthetic organic chemists. As a result, several rational techniques have been developed including intramolecular SN2 reactions, reductive amination reactions, conjugate addition reactions, metal- and acid-catalyzed cyclizations, and ring-closing olefin metathesis reactions. Despite the many available routes, the carboamination strategy could be one of the best techniques considering stereoselectivity and the step economic path toward the formation of ring compounds in an elegant way.Alkylative cyclization with CN bond formation (N-alkylation) is one of the most important methods in organic synthesis for the construction of aza-cycles. Many well-known name reactions (e.g., aza-Diels-Alder, aza-Michael, aza-Mannich, aza-Henry reactions, etc.), which are generally being employed in the intramolecular CN bond formation step, can be treated as CN alkylative cyclization. It is an extremely powerful method for the stereoselective synthesis of N-heterocycles like aziridines, azetidines, lactams, pyrrolidines, piperidines, amino sugars, and many more, which are the basic structural units present in many natural products and biologically active compounds.

Keywords:

carbo-amination;
alkylative cyclization;
asymmetric;
drug;
natural product;
total synthesis;
CN bond formation;
metal-catalyzed;
organocatalyzed;
chiral amine;
stereoselective;
palladium;
copper;
gold;
N-heterocycle;
aza-Diels-Alder reaction;
aza-Michael reaction;
aza-Mannich reaction;
aza-Henry reaction;
biologically active;
bicyclic;
pharmaceutical


LTHOUGH HIS ACTIVE POLITICAL CAREER was extremely short, the political stance of Anthony Ashley Cooper, third Earl of Shaftesbury (1671-1713), is often characterized by such phrases as "extreme Whig" or "the rabid Whig."' It is undeniable that he was a Whig: his reverence for his grandfather, the first Earl, assured that.2 Yet that very reverence makes such simplistic characterization doubtful, for the vagaries of the Whigs from the Revolution to the rise of Walpole indicate that Whiggery was not clear-cut. Shaftesbury adhered to the basic principles utilized by his grandfather, but these were generally outside the drift of post-Revolution Whiggism. Indeed they bear a marked likeness to the developing Toryism of Bolingbroke and his circle. In this paper I wish to analyze Shaftesbury's political thought in an effort to show that it follows from his cosmic toryism3 and that Bolingbroke's Toryism shares similar roots. Considerable controversy surrounds the discussion of political parties in this period. Robert Walcott argues that the period is one of confused politics because the two-party system was absent.4 Both J. H. Plumb5 and Geoffrey Holmes6 argue for the existence of a two-party system, although they acknowledge many divisions within each of the parties. All agree, however, that there was a court-country division and that this split,


Hydrotreated oil which is sufficiently lowered in oxygen content and n-paraffin content can be manufactured by bringing an oxygenic hydrocarbon containing oil to be treated into contact with a catalyst comprising a carrier containing a crystalline metallosilicate and at least one metal selected from among Group 8 elements of the periodic table which is supported on the carrier in the presence of hydrogen. The hydrotreated oil thus manufactured is useful as low environmental load gasoline base material and the invention also provides lead-free gasoline compositions containing the hydrotreated oil.


First it is important to know whether treatment really has failed, so it is important that you or a nurse know how to reliably identify live lice at all developmental stages, and that you can differentiate hatched eggshells (nits) from potentially viable eggs. Nobody can reliably identify viable eggs, even with the aid of a microscope, unless the young louse can be seen moving inside the shell.

Failure with over the counter products may have two causes: improper use and insecticide resistance.

Inadequate, incomplete or inappropriate applications are the …


The a subunit is the largest of 14 different subunits that make up the V‐ATPase complex. In mammalian species this membrane protein has four paralogous isoforms, a1–a4. Clinically, a subunit isoforms are implicated in diverse diseases; however, little is known about their structure and function. The subunit has conserved, predicted N‐glycosylation sites, and the a3 isoform has been directly shown to be N‐glycosylated. Here we ask if human a4 (ATP6V0A4) is N‐glycosylated at the predicted site, Asn489. We transfected HEK 293 cells, using the pCDNA3.1 expression‐vector system, to express cDNA constructs of epitope‐tagged human a4 subunit, with or without mutations to eliminate the putative glycosylation site. Glycosylation was characterized also by treatment with endoglycosidases; expression and localization were assessed by immunoblotting and immunofluorescence. Endoglycosidase‐treated wild type (WT) a4 showed increased relative mobility on immunoblots, compared with untreated WT a4. This relative mobility was identical to that of unglycosylated mutant a4N489D, demonstrating that the a4 subunit is glycosylated. Cycloheximide pulse‐chase experiments showed that the unglycosylated subunit degraded at a higher rate than the N‐glycosylated form. Unglycosylated a4 was degraded mostly in the proteasomal pathway, but also, in part, through the lysosomal pathway. Immunofluorescence colocalization data showed that unglycosylated a4 was mostly retained in the ER, and that plasma membrane trafficking was defective. Co‐immunoprecipitation studies suggested that a4N489D does not assemble with the V‐ATPase V1 domain. Taken together, these data show that N‐glycosylation plays a crucial role in a4 stability, and in V‐ATPase assembly and trafficking to the plasma membrane. J. Cell. Biochem. 117: 2757–2768, 2016. © 2016 Wiley Periodicals, Inc.


The present invention discloses a method for interactive multi-party communication, the method comprising: establishing a first wireless connection between the mobile terminal and at least a second mobile terminal directly connected; to the bottom of the direct radio link to the said first terminal is a mobile server multiparty interactive communications application, said at least a second mobile terminal is a multi-client interactive communication application, to establish the first mobile terminal and at least one second mobile terminal as a participant multiparty interactive communication connection; the first mobile terminal and at least a second mobile communication terminal using the interactive multi multiparty interactive communication connection. The present invention also discloses another method and two kinds of multiparty interactive communication apparatus multiparty interactive communication to achieve. By the above method, the present invention can be in the case of poor network conditions, the use of wireless communications multiparty interactive communication between a mobile terminal.


The invention discloses an image sensor and an optical navigation unit with the same. The image sensor comprises sensing pixels and a control circuit. The sensing pixels include a charge storage element, an optical sensing element and a switch element; the optical sensing element generates optical sensing charges of first and second optical charge quantities in first and second modes, respectively; the switch element determines the quantity of the optical sensing charges which can be transmitted to the charge storage element, according to control voltage. The control circuit generates the control voltage, so that in the first mode, first ones of the optical sensing charges can be transmitted to the charge storage element, while in the second mode, the second ones of the optical sensing charges can be transmitted to the charge storage element; both the first ones and the second ones are less than maximal storage quantity of the charge storage element.


The present study reports five CD8+, CD56+ (natural killer (NK)‐like) T‐cell lymphomas involving the small intestine without evidence of enteropathy, from Japan. Three were intestinal T‐cell lymphoma. The site of origin of the other two was not definitive. Four of five patients underwent emergency operation because of intestinal perforation. The small intestines of these patients had multiple ulcerative lesions with or without demarcated tumors. Histologically, the lymphoma cells were monomorphic or slightly pleomorphic and displayed epitheliotropism of varying degrees. Lymphoma cells of all patients shared the common phenotype: CD3+, CD4−, CD5−, CD8+, CD56+, CD57−, T‐cell intracellular antigen‐1+, granzyme B+. In contrast to nasal/nasal type NK‐cell lymphomas, they had clonal rearrangement of T‐cell receptor(TCR) genes and were negative for EBV‐encoded RNA. Immunohistochemistry and genetics suggested that three cases were of αβT‐cell origin and two cases were of γδT‐cell origin. There was no evidence of enteropathy in any patient. The cases followed a clinically aggressive course with a frequent involvement of lung. According to the classification based on the recent genetic studies of European enteropathy‐type intestinal T‐cell lymphoma (ETL), the present cases could be classified as type 2 ETL.


Republicans and Democrats increasingly distrust, avoid, and wish harm upon those from the other party. To make matters worse, they also increasingly reside among like-minded others and are part of social groups that share their political beliefs. All of this can make expressing a dissenting political opinion hard. Yet digital and social media have given people new spaces for political discourse and community, and more control over who knows their political beliefs and who does not. With Democracy Lives in Darkness, Van Duyn looks at what these changes in the political and media landscape mean for democracy. She uncovers and follows a secret political organization in rural Texas over the entire Trump presidency. The group, which organized out of fear of their conservative community in 2016, has a confidentiality agreement, an email listserv and secret Facebook group, and meets in secret every month. By building relationships with members, she explores how and why they hide their beliefs and what this does for their own political behavior and for their community. Drawing on research from communication, political science, and sociology along with survey data on secret political expression, Van Duyn finds that polarization has led even average partisans to hide their political beliefs from others. And although intensifying polarization will likely make political secrecy more common, she argues that this secrecy is not just evidence that democracy is hurting, but that it is still alive, that people persist in the face of opposition, and that this matters if democracy is to survive.


Objective To investigate the clinical features of 94 elderly cases with non-small lung cancer(NSCLC). Methods Ninety-four elderly cases≥65 years old with NSCLC were enrolled from May 2009 to April 2010,and the clinical stages, pathological type, sex distribution,and concomitant diseases were retrospectively analyzed. Results During the study period, the rate of the male to female is 1.94. The mean age of patients was 71.2±4.61 years (range: 65-86). The main pathological type is adenocarcinoma (68.1%); The most frequent concomitant diseases were cardiovascular diseases (57.4%), diabetes (12.8%). Conclusions Most elderly patients with NSCLC are male and have more accompanying diseases. The pathological type is mainly adenocarcinoma.


We study how Suarez deepened a tradition decisive to strengthen the idea of universal community of supra-state nature, based on moral rules superior to the sover-eignty of the states, on the dignity of the human person, on the unit of the Human genre, on the universal common good and natural equality of the sovereigns of the world, both from the point of view of the domain of jurisdiction and of the property, supported by democratic conceptions about the origin of civil power. A concept of a community not only international but universal was thus affirmed, while the legitimacy of indigenous sovereignties in the New World was undermined, because civil power did not lie in faith or charity, but in natural reason and in sociability of men.


It is described a system and method for compressing data to be transmitted. Data stream, such as byte code sequence is divided into one or more data chunks. Data chunks may be associated with an identifier, such as one data chunk and other chunks of data and the distinguishing signatures. Thus, different data chunks will become identifiable through different signatures. Data chunks associated with the signature may be compared with the repository or the history buffer. History buffer is associated to each signature, already contains a collection of the transmitted data chunks.


Societies are transforming from information societies into knowledge societies. E-resources play an important role by providing a convenient medium and fast access to a vast range of information. Present paper attempts to identify the trends in using E-resources by various user groups. Distribution of user studies are studied with respect to place of publication, resource-wise, type of user, purpose-wise, subject-wise, year of publication, time lag in publication, language-wise, publication-wise etc. The study shows that academics prefer to use e-journals over other e- resources and that both print and e-resources complement each other.


[Objective] The study was to prevent the decrease of performance of Yinchang white goat and improve its present situation of growth.[Method] With selected Yinchang white goats provided by improved variety breeding farm in Wangjiafan township in Yidu City as observed goats,the growth characteristics of ram and ewe with nascent,2 month old,6 month old and yearling were observed and their growth performance were determined.[Result] The selected Yinchang white goats had stuggy limbs,wide back,developed hindquarter,plump muscle,good gregariousness and good feed intake ability during grazing.And the goats adapt to local climate and extensive feeding and management condition.The average birth weight of selected ram and ewe of Yinchang white goat was 1.86 kg,and the average weight of goats with 2 month old,6 month old and yearling were 7.07,12.75 and 19.69 kg resp,increasing by 11.87%,17.08% and 23.29% resp.than that before selection.The withers height,body length and chest circumference of selected Yinchang white goats were all higher than that before selection at each growth stages.[Conclusion] The growth performance of selected Yinchang white goat was increased,and the breeding effect was obvious.


A brownish coloring in the Lebanese coastal water of the area Zouk - Nahr el Kelb area was detected in May 2007. The qualitative and quantitative analyses, in comparison with preceding data, showed that this phenomenon was due mainly to the massive and exceptional bloom of both a centric diatom Skeletonema costatum (Greville) Cleve reaching 1,6 × 10 7 L -1 cells and of an ichtyotoxic raphidophyte Heterosigma akashiwo (Hada) Hada reaching approximately 9 × 10 6 L -1 cells. The maximum of this proliferation was located in surface water opposite Zouk power plant where the measured rates of chl-a reached 32 mg.m -3 indicating a phenomenon of eutrophication. Attempts were made at explaining the mechanism of development of this algal bloom. The hydro-climatic conditions prevailing during a heat wave coupled with nutrient availability are probably the cause to the development of this phenomenon. The fact that the benthic cysts produced by the cells of H. akashiwo may


In thecalibration ofa microwave radiometer, the calibration loadisequipped with a metallic shield. Themetallic shield isfound tointroduce aberration tothemeasurements ofthe antennatemperature. Inthiswork, a ray-tracing modelis constructed fortheaberration analysis, whichisbased on the radiation transfer theory taking into accountboththeconductivity ofthemetalandthetemperature distribution oftheshield. Calculation results indicate that thetemperature aberration dueto themetal shield canbeuptoafewtenths ofKelvin, depending on themetal, thegeometry oftheshield andthesize oftheantenna. Thecalculation result isalsocompared withtheexperimental data. IndexTerms.Radiometer calibration, brightness temperature, radiation transfer theory


A frontier in hydrology lies in understanding the potential impacts of a warming planet on water cycle variability from regional to global scales.  The fluxes that constitute the terrestrial water cycle present various complexity in observability, with Evapotranspiration (ET) being generally the most challenging variable to quantify directly.  Because of the ability to apply mass conservation and to "close" a water flux budget across scales, mass change measurements present the best opportunity to quantify evapotranspiration and changes in evapotranspiration at larger scales, ranging from basins to global. Here we present work on: (1) using GRACE/GFO observations to estimate basin-scale ET in the continental United States as a target for validation and error analysis of up-scaled ET products from other sources, and (2) using GRACE/GFO observations to estimate ET globally over the full joint record (2003-2020) in order to quantify observed changes in the global water cycle.  We find that because of the way that errors in mass change measurements inherently change in scale (i.e. decreasing with larger study domains), GRACE/GFO measurements offer a very clear and robust uncertainty quantification approach for large scale ET monitoring.  We also find that there is a clear and statistically significant signal in global land ET over the record length that indicates changes in the global water cycle consistent with our understanding of climate change.  These methods and results will be presented and discussed.


ABSTRACT The present work aims to perform an experimental reuse study of raw and sustainable treated urban wastewaters in the irrigation of alfalfa (Medicago sativa L.) under semi-controlled conditions. The obtained results highlight a significant effect (p < 0.05) of water quality on soil monitored parameters. Compared to control soils irrigated with groundwater (GW), those irrigated with treated urban wastewaters from the modified activated sludge process (PTW) and raw urban wastewater (RW) showed significant increase in their organic matter (OM) and nutrients content. Indeed, in comparison to GW organic matter (OM) of RW and PTW was 5,37 and 3,84 times higher; Kjeldahl nitrogen (TKN) was 3,50 and 2,81 times higher and total phosphorus (TP) was 4,00 and 3,25 times higher, respectively. The results showed also a significant effect of water quality on yield, macro and microelements concentrations of alfalfa plant. Hence, the highest yield, macro and microelements uptake of the plant were obtained in response to irrigation with PTW and RW compared to control soil GW. Concerning trace metallic elements concentrations, pots irrigated with RW and PTW showed relatively higher concentrations than those of GW pots.


Sn-0.7Cu-0.05Ni is a widely used Pb-free solder that solidifies into a near-eutectic microstructure and a small fraction of primary Cu6Sn5. This paper overviews in-situ time-resolved imaging experiments on the solidification of Sn-0.7Cu-0.05Ni solder under three conditions: (i) directional solidification, (ii) continuous cooling in a near-uniform thermal field, and (iii) solder joint solidification on a Cu substrate. Primary Cu6Sn5 grow as rods along [0001] in each case but can also grow as X-shaped crystals in (iii). There are significant differences in eutectic growth due to nucleation difficulties for tin in conditions (ii) and (iii).


The deposition of radioactive yttrium in bone has generated considerable interest for a number of reasons. Not only is yytrium a fission product of some importance, but its chemistry and behavior in the animal differ markedly from that of calcium. Yttrium tends to deposit selectively in resorption cavities (1, 2). Calcium tends to concentrate in areas of new growth (3). Both, however, seem to be interacting with the inorganic crystals (4, 5). To account for these peculiar differences, several groups of investigators have sought answers in terms of the physicochemical state of yttrium in body fluids and its mode of transport in vivo (4, 6, 7). Experimentally, however, many difficulties are encountered because of yttrium's tendency to hydrolyze in near-neutral solutions. Dearnaley (8), for example, avoided the problem of hydrolysis (and simultaneously sharply delimited the physiological significance of the results) by studying the complexing of yttrium by various ligands at acid pH only (5.3 or less). Despite the difficulties involved, the present studies were undertaken to survey various physiologically important ligands for their ability to interact with yttrium at physiological pH. Admittedly, the results must be regarded as semiquantitative at best and qualitative at worst. The number of interacting variables (carrieryttrium concentration, age of colloid, size of colloid, nature of reaction vessel, etc.) is so great that it is virtually impossible to apply sophisticated methodology at the present time. Accordingly, relatively simple parameters were investigated with relatively simple techniques, such as filtration, ultrafiltration, and electrophoresis. Although final conclusions are not possible at the present time, the results are very compatible with earlier studies of beryllium transport (9): that is, (1) at


This is an introduction to topology of complement to plane curves and hypersurfaces in the projective space and is based on the lectures given in Lumini in February and in ICTP (Trieste) in August of 2005. We discuss key problems concerning the families of singular curves, the one variable Alexander polynomials and the module over ring of Laurent polynomials structure on the homotopy groups of the complements to hypersurfaces with isolated singularities. We also discuss multivariable generalizations of these invariants and the Hodge theory of infinite abelian covers used in calculations of multivariable invariants. A historical overview is included as the opening section


The medical education in our country is facing a new challenge,we should coalesce with the international standard protocol. Capital Medical University has reformed the original educational system, which made 12 basic subjects into four experimental module in order to increase the general educational level, enhance to syncretize knowledge from each subject and make the experimental facilities shared.The microscopic mutual motivation utilized in the morphology training course is a revolutionary change in the microscopic world of morphology education by the development of computer, Internet and digital technology. It is a new topic that the traditional teaching method is replaced by the digital internet microscopic virtual teaching system, which brings the morphologic experimental teaching a higher attitude.But also many problems need to be resolved.Teaching reform is a form of scientific research activity, and we should utilize the advantages and deny the disadvantages of the three foreign teaching methods which are OBL,PBL,CBL. We should make this education reform as a good opportunity to keep reforming the morphologic teaching system, which will provide a solid theoretical evidence for the education reform in university.


Abstract : The Presidential Commission on the Assignment of Women in the Armed Forces has expanded the role of women in the military with its new 'gender-neutral' assignment policy. NAWCADWAR is conducting a series of tests to determine 'gender neutral' dynamic strength requirements for small stature females performing operationally relevant tasks in a high performance cockpit. This report contains a bibliography of the results of a literature review conducted prior to drafting a human use test plan. It is not intended to be an extensive review of all areas in which male and female strength capabilities differ. Instead it highlights information pertinent to strength assessments in general, measurement modalities and interpretation, published male and female strength data as well as extrapolated female strength capabilities under normal and in acceleration environments and specific strength requirements associated with high performance flight under normal and emergency conditions. It also contains a list of other bibliographies which compile gender related differences in human factors and performance.


Abstract Background The SENTRY Antimicrobial Surveillance Program monitored the etiology of bloodstream infections (BSI) and other infections worldwide since 1997. We evaluated the results for BSI in the United States (US) and Europe (EU). Methods Organisms were consecutively collected (1/patient) from 79 medical centers located in the US (n=12,748; 35 centers), western EU (W-EU; n=12,198; 29 centers from 10 nations: Belgium, France, Germany, Ireland, Italy, Portugal, Spain, Sweden, Switzerland, and the United Kingdom), and eastern EU (E-EU; n=3,297; 15 centers from 12 nations: Belarus, Croatia, Czech Republic, Greece, Hungary, Israel, Poland, Romania, Russia, Slovakia, Slovenia, and Turkey). Organisms were susceptibility tested by reference broth microdilution methods in a central laboratory. Results The most common organism found was S. aureus in the US and E. coli in W-EU and E-EU (Table). E. coli, S. aureus, and K. pneumoniae represented the top 3 organisms in all 3 regions and accounted for 53.9–54.8% of the collection. Gram-negative bacilli (GNB) represented 48.8% of organisms in the US, 59.8% in W-EU, and 65.6% in E-EU. MRSA rates were higher in US (41.6%) compared to W-EU (24.4%) and E-EU (24.6%). In contrast, susceptibility to ceftriaxone and levofloxacin among E. coli were lower in E-EU (66.4% and 55.8%, respectively) compared to W-EU (83.3% and 73.5%, respectively) and the US (83.0% and 65.8%, respectively). Among K. pneumoniae, susceptibility to ceftriaxone and meropenem were 86.6% and 98.7% in US, 64.3% and 84.7% in W-EU, and 30.2% and 72.5% in E-EU, respectively. CRE rates were lower in US (0.5%) compared to W-EU (2.8%) and very high in E-EU (10.4%). P. aeruginosa susceptibility to piperacillin-tazobactam and meropenem were 84.8% and 83.7% in US, 81.4% and 82.3% in W-EU, and 64.6% and 57.6% in E-EU, respectively. Vancomycin-nonsusceptibility (VRE) rates in the US, W-EU, E-EU were 3.2%, 0.9%, and 2.7% among E. faecalis, and 64.6%, 18.2%, and 30.6% among E. faecium, respectively. Table 1 Conclusion The frequency of GNB was lower in the US compared to W-EU and E-EU. Antimicrobial resistance rates among Gram-positive cocci were higher in the US compared to W-EU and E-EU; whereas, among GNB, resistance rates generally were higher in E-EU compared to W-EU and the US. Disclosures Helio S. Sader, MD, PhD, A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Melinta (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Paratek Pharma, LLC (Research Grant or Support)Pfizer (Research Grant or Support) Mariana Castanheira, PhD, 1928 Diagnostics (Research Grant or Support)A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Amplyx Pharmaceuticals (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Fox Chase Chemical Diversity Center (Research Grant or Support)GlaxoSmithKline (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Paratek Pharma, LLC (Research Grant or Support)Pfizer (Research Grant or Support)Qpex Biopharma (Research Grant or Support) Cecilia G. Carvalhaes, MD, PhD, A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Fox Chase Chemical Diversity Center (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Pfizer (Research Grant or Support) Rodrigo E. Mendes, PhD, A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Basilea Pharmaceutica International, Ltd (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Department of Health and Human Services (Research Grant or Support)GlaxoSmithKline (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Pfizer (Research Grant or Support)


The mu Iti—purpose simulation person applies in the diagnostics puncture experiment teaching.Its superiority for overcomes the teacher teaching monotonous,stereotypical and the too Abstract shortcoming Overcomes the student to study the initiative not not strongly,accepts the knowledge difficult shortcoming;Can solve the typical case of illness insufficiency,the patient coordinates questions and so on difficulty.its insufficiency for simulates the puncture method in the multi—purpose puncture which the human implements to have the distorted phenomenon.


Melioidosis is a tropical disease of high mortality caused by the environmental bacterium, Burkholderia pseudomallei. We have collected clinical isolates from the highly endemic Northern Territory of Australia routinely since 1989, and animal and environmental B. pseudomallei isolates since 1991. Here we provide a complete record of all B. pseudomallei multilocus sequence types (STs) found in the Northern Territory to date, and distribution maps of the eight most common environmental STs. We observed surprisingly restricted geographic distributions of STs, which is contrary to previous reports suggesting widespread environmental dissemination of this bacterium. Our data suggest that B. pseudomallei from soil and water does not frequently disperse long distances following severe weather events or by migration of infected animals. The soil and water Gram-negative bacillus, Burkholderia pseudomallei, is the etiological agent of melioidosis, a potentially life-threatening infectious tropical disease. Melioidosis is highly endemic in northern Australia and northeast Thailand, with increasing recognition outside these traditional regions. Melioidosis has a high mortality rate; 14% in Australia and up to 40% in Thailand, where it is the largest cause of infectious disease death after human immunodeficiency virus and tuberculosis. B. pseudomallei is classified as a Tier 1 select agent in the United States because it is intrinsically resistant to many antibiotics, there is no vaccine and aerosolization has potentially high lethality. Burkholderia pseudomallei is one of an increasing number of bacterial species known to show robust biogeographic structure. In particular, there is a clear and robust phylogenetic division between Australian and southeast Asian strains, with almost no overlap between the environmental strains found in Australia and those in southeast Asia. An apparent exception was the presence of two multilocus sequence typing (MLST) sequence types (STs) common to both Australian and Cambodian B. pseudomallei strains (ST-105 and ST-849). However, for both these STs, isolates from Australia and Cambodia were found to be widely divergent at the whole-genome level, indicating that they were unrelated and the MLST identity represented homoplasy. Within Australia, some genetic population structure among different locations has been detected. In particular, there are no shared environmental STs between the Northern Territory and Queensland. Confirmation of population structure at increasingly fine scales suggests that the bacterium has limited dispersal ability. Limited dispersal is unexpected, because the species can be carried by agricultural animals and is relatively resistant to environmental stress. Its ability to cause infection when inhaled makes it plausible that B. pseudomallei could be dispersed in severe weather events such as cyclones. This bacterium is also able to move in the water table and presumably to track along waterways, to be transported in soil used for gardening, building and farming, and to live in the aerial parts of grasses. In addition, B. pseudomallei has been isolated from the beak of a healthy bird, suggesting another possible mode of longdistance dissemination. B. pseudomallei can also seed new endemic areas and cause long-term contamination of soil and water outside of the tropics. Taken together, these findings suggest that this organism has many opportunities to disperse widely. However, an important factor likely to limit dispersal is the sensitivity of B. pseudomallei to ultraviolet radiation, which has been exploited to eradicate the bacteria from unchlorinated bore water supplies. The Northern Territory of Australia, with an area of 1,346,200 km, lies between latitudes 11 and 26°S. The most northerly tropical region of the Northern Territory, known as the "Top End," is subject to monsoonal weather patterns. In contrast, the southerly and western regions are characterized by hot semi-arid and arid deserts. The Northern Territory has a population of approximately 245,000 people and has been sparsely occupied throughout its history from first settlement over 40,000 years ago, and since European settlement in the early nineteenth century. Just over half the current population is concentrated in the Northern Territory's capital city, Darwin (12°S), on the northern coastline. Most of the remainder of the population is settled in smaller towns and remote indigenous communities throughout the Territory and on its northern offshore islands. Although melioidosis is highly endemic in the tropical Top End, sporadic cases are occasionally seen in the normally arid Central Australia, south of latitude 20°S, such as occurred following unusually heavy rain in 2011. Herein we report the geographical distribution of B. pseudomallei STs within the Northern Territory. We use data from over 3,000 environmental strains collected since 1991 at the Menzies School of Health Research in Darwin, Australia. We have mapped the geographical distribution of the most common B. pseudomallei STs in environmental samples in the Northern Territory; specifically, those that have been found in 10 or more unique environmental samples. We also report the complete list of environmental, animal, and human clinical B. pseudomallei STs recorded in our sampling efforts across the Northern Territory, up until January 28, 2015. The earliest clinical sample in our data set is from 1980, with all other clinical samples collected prospectively from melioidosis cases since the commencement of the Darwin Prospective Melioidosis Study on October 1, 1989. *Address correspondence to Bart J. Currie, Menzies School of Health Research, PO Box 41096, Casuarina, Northern Territory 0811, Australia. E-mail: email@example.com


In 1961, the Christian Council of Ghana, a national association of the Orthodox Protestant Churches, introduced family planning as a public service in Ghana. The Planned Parenthood Association of Ghana (PPAG) was formed in March 1967; its objectives were to educate the public on the benefits of family planning and to offer family planning services. The philosophy underlying the provision of family planning in Ghana is that relevant aspects of family planning should be integrated into the ongoing activities of both government and nongovernmental organization programs. Diseases caused by parasitic agents constitute some of the important health problems in Ghana. Some of the objectives of the PPAG are: 1) to collect basic information about health, nutrition, family planning, and socioeconomic status of some selected Awutu populations through a baseline survey, 2) to improve the health and socioeconomic welfare of the population in the selected area through health and family planning education, 3) to promote better health through education of community members, and 4) to establish the prevalence rate of intestinal parasitic infestation in the Awutu District and treat the positive identified cases carrying the parasites.


The 1,4-arene migration from a carbon to a nitrogen center, induced by iminyl radicals generated from radical additions to vinyl azides, is reported. Two different modes of vinyl azide activation trigger this migration process, which offers a mild route for the synthesis of trifluoromethyl- or sulfonyl-substituted β-enamino ketones. Mechanistic studies reveal a dual role for the silver catalyst and provide insight into the nature of the migration by demonstrating the positional influence of arene substituents on arene migratory aptitude. By in situ generation of the key migration substrate from readily available precursors, this method offers a novel strategy for achieving remote C- to N-group migration, and more generally for the formal activation of C–C bonds.


It is shown that there is the possibility to find at least in the perturbation framework the Matsubara theory from the $S-$matrix interpretation of the real-time finite-temperature theory if the system under consideration is in an equilibrium state.


Objective:To analyze the clinical manifestations and immunological findings in 408 patients with systemic lupus erythematosus(SLE) . Methods:A database of 408 patients,who was diagnosed SLE in the First Affiliated Hospital of Nanjing Medical University in 2004 to 2007,was established and the data was analyzed by SPSS13.0 software. Results:The most common clinical manifestation was renal injury and the most common immunological abnormity is ANA(+) ,accounting for 82.1% and 91.9% the total respectively. There were some differences in the positivity rates of malar rash,discoid rash,fever,lung injury,ds-DNA and the proportion of SLEDAI≥9 between the more than 50 years old group and the less than 50 years old group. Between the male group and the female group,differences in the aspects of renal injury,photosensitivity and hypoalbuminemia were also found. Conclusions:SLE was a multisystemic disease causing several combinations of different characteristic symptoms and laboratory abnormalities. To take great emphasis on early diagnosis may contribute to prevent or slow down the course of the disease and to improve the prognosis.


The alarm communications system can be thought of as consisting of five major components: alarm transmission, alarm displays and stations, alarm processing and software, line supervision, and other (e.g., enclosure protection). The authors illustrate a typical alarm communications system. The focus is on line supervision, particularly between the sensors and multiplexers. Modules from commercial vendors are being developed to provide enhanced line security (ELS) between the sensors and the data gathering panels or multiplexers (MUX). These modules are a promising new option for a physical protection system, and details concerning the evaluation and specific design requirements and functions are presented. The ELS systems currently being evaluated provide point-to-point protection between the sensor and MUX. The ELS systems were very reliable and required no maintenance once they were installed. The impact of encryption on the timely performance of the alarm communications system was evaluated.<<ETX>>


The invention discloses a service processing method and an intelligent network system. The method comprises that: the intelligent network system receives an intelligent network service request message used for making a request for the execution of an intelligent network service; the intelligent network system determines that a database in the intelligent network system is in an anomalous state; and the intelligent network system executes the intelligent network service. The service processing method and the intelligent network system have the advantages of maximally ensuring the smooth execution of the intelligent network service and improving user experiences.


Introduction: Pain and limitation of movement can be seen in patients who underwent tube thoracostomy after thoracic surgery.
Objective: This study was conducted to examine the pain levels and activities of daily living of patients who underwent tube thoracostomy after thoracic surgery.
Method: The study is a descriptive and correlational study. The sample consisted of 130 patients who underwent tube thoracostomy after thoracic surgery in two university hospitals. Individual Characteristics Form, Mcgill Melzack Pain Questionnaire, Visual Analog Scale and Katz Daily Living Activities Index were used in our research. In the analysis of the data, Kruskal Wallis, sperm correlation and linear regression analysis were performed.
Results: The mean age of the patients who underwent tube thoracostomy after thoracic surgery was 54.46±16.39 years. 67.7%of the patients were male and 63.8%were operated with the thoracotomy method. The mean pain score of the patients was 4.15 ± 2.42 (out of 10). According to the Mcgill Melzack Pain Questionnaire, 55.4%of the patients stated that moving increased their pain. It was found that 75.4%of the patients were dependent on dressing and 50.8%in bathroom activities. A statistically significant negative moderate correlation was found between Katz Activities of Daily Living Index total score and pain score averages (r: .44, p:0.000). The prediction between the independent variables of patients' gender, age category, surgery method, total score of activities of daily living and pain intensity was examined. It was found that the independent variables of the patients' gender (β:.-232 p: .004) and ADL total score (β:-.373 p: .000) significantly predicted the severity of pain and the model was significant (p:.000). It was found that the variables explained 27%of the total variance.
Conclusion: It was determined that the patients experienced moderate pain after the surgery and they were found to be addicted in their daily living activities. As the pain severity of the patients increases, their addiction in daily living activities increases.
Key Words: Thoracic Surgery, Tube Thoracostomy, Pain, Activities of Daily Living, Nursing.


The possibility of obtaining reliable estimates of the total number of Sertoli and Leydig cells from biopsies by use of the optical fractionator method was tested. The total number of Sertoli and Leydig cells was 522x10 6 (CV = 0.27) and 89x10 6 (CV = 0.34), respectively, when sampling in the entire testis while the mean total number of Sertoli and Leydig cells, sampling from biopsies, was 494x10 6 and 103x10 6 , respectively, statistically a non-significant difference. The present study indicated that total number of testicular cells can be estimated stereologically from the number of cells in biopsies if the sizes of testis and the biopsy can be assessed with adequate precision.


Abstract : A piezoelectric material is formed from conductively anisotropic crystals by exposing the crystals to an AC electrical field, cold-pressing the crystals while still under the influence of the field, then processing the crystals to a dense piezoelectric material, by hot pressing for example.


Dysprosium-modified carbon black filled powdered NR[P(NR/HAF-Dy)] was prepared by liquid-phase chemical deposition and coacervation-coprecipitation,and its capillary extrusion rheological properties and Garvey die extrudability were investigated,compared with traditional carbon black filled powdered NR[P(NR/HAF)] and NR/carbon black blends(NR/HAF) prepared through dry mixing.The results showed that in wide range of temperatures(90~150 ℃) and shear rates(20~1 500 s-1),the order of the apparent shearing viscosity for 3 different mixes was as follows:P(NR/HAF-Dy)P(NR/HAF)NR/HAF.P(NR/HAF-Dy) possesses very low apparent shearing viscosity and stable non-Newtonian fluid flowing properties.The order of the Garvey die extrudability for 3 different mixes was as follows:P(NR/HAF-Dy)P(NR/HAF)NR/HAF.


Purpose

This research contributes to the literature on workplace energy conservation by examining the predictors of individual employee behaviors and policy support in a university. The purpose of this research is to better understand what factors influence energy conservation behaviors in this setting to inform programs and interventions.

Design/methodology/approach

This project gathered survey data from employee-occupants of three campus buildings. Ordinary least squares regression analyses were used to investigate the theory of planned behavior (TPB) and attitudes-behavior-constraints (ABC) models examining what drives energy behaviors.

Findings

This study finds a large proportion of respondents would support energy use reduction policies, more technology-based interventions and increased use of renewable sources. Respondents report positive attitudes toward individual energy conservation behavior but mild agreement with the influence of social norms. Self-efficacy reports also are positive. Although the TPB model is not fully supported in this group, the ABC model appears to perform well.

Originality/value

In addition to adding to the relatively limited data on employee energy-saving behaviors in the university workplace, this study provides initial evidence that the ABC model is pertinent to this behavioral context. It also provides specific, usable data about policies and actions that campus community members might deem feasible and acceptable to relevant university offices.


Based on several indexes, this article investigates technological upgrading in China's exports. It demonstrates that the whole technological contents of China's exports have been improved dramatically since the early 1980s. In the meantime, the domestic technological contents are likely experiencing a V-curve, i.e. decreasing first and then increasing later. Native enterprises grow faster than their foreign direct investment (FDI) counterparts through 'learning-by-doing', and the gap between them is narrowing. It is shown that China's exports have adopted a limited catch-up strategy rather than solely following its comparative advantage. Under the limited catch-up strategy, China exports products with technological contents higher than what was predicted by its comparative advantage. In addition, the experience of South Korea and Taiwan as well as cross-country comparison demonstrates that adopting a limited catch-up strategy is conducive to economic development. We argue that this is what is taking place in China.


This thesis have been conducted at IKEA of Sweden in Almhult. IKEA of Sweden are the product development company in the IKEA group. IKEA of Sweden consist of several Business Areas (BA). Each B ...


Novel dinuclear manganese(III) complex with a new dodecadentate ligand, 1,4,8,11-tetrakis(2-5-chlorosalicylideneaminoethyl)-1,4,8,11-tetraazacyclotetradecane (H4L), [Mn2(L)(CH3COO)2]·2CHCl3 has been synthesized and characterized by X-ray crystallography.


The current article reveals pedagogical mechanisms of  interaction among families, mahallas and educational establishments with civil society institutions in the process of developing of the culture of the youth healthy lifestyle; it substantiated the role and  significance of national pedagogy, the heritage of eastern thinkers of the Middle Ages in developing the culture of the youth healthy lifestyle; exposed the content of special course for master degree students, forming  their conviction for the necessity of operating the culture of healthy lifestyle.


The present invention relates to a protective clothing unit, in particular a textile protective clothing unit, preferably a protective clothing unit with splinter and / or fragment protection and / or ballistic protection function, and their use.


The structure of inter-digital capacitance loaded loop resonator (IDCLLR) is employed for designing microstrip (MS) band-stop filter (BSF), it benefits from its miniaturization and design flexibility due to more structural parameters. Three kinds of IDCLLR-based MS-BSF are presented in this article. Firstly, a 6-stag MS-BSF consisting of a MS-line coupled with uniform pairs of IDCLLRs, and then a 9-stag MS-BSF with nonuniform pairs of IDCLLRs, are designed and tested. Secondly, to replace the IDCLLR by its complementary structure, named as C-IDCLLR with stronger coupling to the MS-line, a 8-stage C-IDCLLR-based MS-BSF with wider stop-band and sharper edge-slope is designed and tested. Finally, the IDCLLR surrounded by meandered MS-line can result in stronger coupling, hence a compact 3-stag IDCLLR-based meandered MS-BSF with good performances is designed and tested.


The article is devoted to the determination of correlation between such fields of knowledge as advertisement, marketing and management. The author suggests her own point of view in the question as a teacher of one of the chairs of OmSTU at the same time as different opinions of others.


Abstract This dissertation was written as part of the MSc in Banking and Finance at the International Hellenic University. This study addresses the effect of capital structure on profitability of listed non-financial firms in the United States. Similar to Abor's (2005), and Gill, et al., (2011) investigation of industrial companies in Jordania. Although, it will be implemented a Sector Analysis through a 9year-period sampling the companies with the largest market capitalization. Research questions that are analyzed in this study: How capital structure decision affects the profitability of large-cap firms? Does the Sector factor affect the sensitivity of profitability results? One preliminary point of this dissertation is that Sector dependence should impact the capital structure of a company. This study sample encompasses 364 companies across ten sectors. Models are structured having as dependent variables the ROA, ROE and Gross Profit Margin. Applying panel data analysis for each sector and identifying the correlation matrixes and descriptive statistics, the results expose three levels of mixed negative and positive effects. Specifically, regarding the high-level effects, the most negatively dependent Sector on leverage is the Information Technology sector, indicating that profitable companies of this Sector choose primarily the equity financing. The inverse is objected for Industrials Sector. In addition, limitations through the whole process are presented, suggesting topics for further research regarding medium and small-cap firms or other explanatory variables. The paper suggests that profitability ratio sensitivities regarding the capital structure alter significantly between the ten sectors studied.


The use of mathematical modeling to predict the behavior of beaches does not work. Some of the major assumptions behind the models used by coastal engineers in the United States are wrong or are unverified. In addition, the models are deterministic and fail to account for the uncertainty of storms or for the chaotic nature of the near-shore environment. The Dutch and Australians do a better job of predicting beach behavior with an observational approach, predicting how a particular beach might behave in the future by studying its past behavior.


The era of big data and cloud computing services has driven the demand for higher capacity and more compact semiconductor devices. As a result, semiconductor devices are moving from 2-D to 3-D. Most notably, threedimensional (3D) NAND flash memory is the most successful 3D semiconductor device today. 3D NAND overcomes the spatial limitation of conventional planar NAND by stacking memory cells vertically. Since hundreds of vertically stacked semiconductor materials become the channel length in the final product, accurate thickness characterization is critical. In this paper, we propose a non-destructive multilayer thickness characterization method using optical measurements and machine learning. For a silicon oxide/nitride multilayer stack of <200 layers, we could predict the thickness of each layer with an average root-mean-square error (RMSE) of 1.6 Å . In addition, we could successfully classify normal and outlier devices using simulated data. We expect this method to be highly suitable for semiconductor fabrication processes.


In this paper we discuss manual and automatic evaluations of summaries using data from the Document Understanding Conference 2001 (DUC-2001). We first show the instability of the manual evaluation. Specifically, the low inter-human agreement indicates that more reference summaries are needed. To investigate the feasibility of automated summary evaluation based on the recent BLEU method from machine translation, we use accumulative n-gram overlap scores between system and human summaries. The initial results provide encouraging correlations with human judgments, based on the Spearman rank-order correlation coefficient. However, relative ranking of systems needs to take into account the instability.


This paper presents a approach on how to reduce stress and fatigability in the user's eyes, muscles and also backbone when the user is using a computer. The study uses image processing technique for the detection of the face of the user. The monitor of the desktop computer is connected with a DC motor that will auto align itself to the face of the user in order to make sure it is in front of the user's face. If the user moves its head sideward the monitor will align and this will help the user to have movements of the bone and also muscles on its back. The movement of the monitor through the microcontroller and also the face detection part was programmed on the python software.


The reduction of energy consumption in buildings is one of the goals to improve energy efficiency. One way to achieve energy savings in buildings is to develop intelligent control heating strategies that are able to reduce the power consumption by predicting the behavior of the thermal dynamics under different control schemes. One way to accomplish this is by means of learning fuzzy rules using the data collected from different sensors installed in buildings to generate regression models that are accurate and interpretable, so the generated models can be understood by the experts who approve the energy-saving schemes. However, one important issue is the generation of accurate knowledge bases of fuzzy rules for regression that can scale with the large amount of information generated by the many sensors installed in buildings, which will continue to grow in the coming years. For this purpose, in this paper we evaluate the scalability of two genetic fuzzy systems, FRULER and S-FRULER in the domain of thermal dynamics in buildings, using real data from a residential college at the USC.


Most mathematical students are familiar with Pascal's statement, made in a communication to a learned society in Paris in 1653, that he had a number of mathematical treatises, chiefly geometrical, ready for publication, amongst them being the following : Conicorum opus completum, et conica Apollonii et alia innumera unica fere propositione amplectens ; quod quidem nondum sex decimum aetatis annum assecutus excogitavi ; et deinde in ordinem congessi.


Dual phase‐compensating spectral/spatial echo‐planar (EP) spin‐echo (SE) pulses were incorporated into the point resolved spectroscopy (PRESS) excitation sequence to improve water and lipid suppression for 1H chemical shift imaging (CSI) and to decrease the dependence of the PRESS box location upon chemical shift. The asymmetric EPSE pulses (either minimum or maximum phase in the chemical shift domain) were substituted for the two PRESS SE pulses to yield zero phase spectra. Three different pulses were designed and tested at 1.5 T. Pulse 1, targeted for brain CSI (TE > 85 msec), passed choline to lipid resonances, suppressed water, and rephased the methyl lactate doublet independently of TE. Pulse 2, targeted for general purpose shorter TE PRESS, possessed both high chemical shift and spatial domain bandwidths. Pulse 3, designed for prostate CSI, passed choline to citrate resonances while suppressing lipids and water. The three pulses possessed spatial bandwidths ranging between 3.3 and 5.0 kHz, more than three times higher than that offered by one‐dimensional SE pulses of equivalent maximum B1 amplitude. Phantom and in vivo experimental results demonstrated that, for EPSE pulses 1 and 2, suppression factors higher than 104 were achieved. The increased spatial bandwidths resulted in less contamination by signals from outside the designated PRESS excited region and a significant improvement in the uniformity of metabolite intensities for voxels located near edges of the PRESS box.


Regional climate models (RCMs) have been increasingly used to simulate the realistic charac‐ teristics of the regional climate and to evaluate the related multiscale interactions [1-4]. A fundamental requirement for the development of RCMs is to examine their capability in simulating the seasonal evolution and interannual variabilities on a regional scale. This seems more important for the simulation of RCMs over East Asia due to the distinct Asian monsoon climate feature. The larger variability and uncertainty of the Asian monsoon system confirmed by extensive observational studies and numerical simulations [5, 6] suggest that the modeling research will be a challenging task because of the complex scale interactions involved.


Cats form social groups in which individuals recognize each other, and the cohesiveness of the group is maintained by a variety of amicable behaviors. We are aimed to provide the available knowledges about the prevention and correction methods for the behavior problems in cats through literature review. As the results, The behavior problems of cats may occur between group members and between group members and non-group members. Within the domestic environment, the behavior problems of cats may become a problem when it is directed at house-mates or humans. Differential diagnosis and treatment of various problems of the behavior problems of cats are discussed.


Conception is a key part in the process of writing and its inevitability is determined by constructiveness of the mental work and creativeness. Non-conception is a generative way of writing and is the reconstruction of consciousness or foregrounding of subconscious when the writer is stimulated by catalyst. During the process of writing, conception and non-conception coexist and are complementary.


RAS-mediated human cell transformation requires inhibition of the tumor suppressor Protein Phosphatase 2A (PP2A). Both RAS and PP2A mediate their effects by phosphoregulation, but phosphoprotein targets in which RAS and PP2A activities converge in human cancers have not been systematically analyzed. Here, based on mass spectrometry phosphoproteome data, we discover that phosphosites co-regulated by RAS and PP2A are enriched on proteins involved in epigenetic gene regulation. As examples, RAS and PP2A co-regulate the same phosphorylation sites on HDAC1/2, KDM1A, MTA1/2, RNF168 and TP53BP1. Mechanistically, we validate co-regulation of NuRD chromatin repressor complex by RAS and PP2A. Consistent with their known synergistic effects in cancer, RAS activation and PP2A inhibition resulted in epigenetic reporter de-repression and activation of oncogenic transcription. Notably, transcriptional de-repression by PP2A inhibition was associated with increased euchromatin and decrease in global DNA methylation. In RAS-driven cancers, PP2A activity is inhibited by nuclear PP2A inhibitor proteins PME-1 and SET. We further demonstrate that these PP2A inhibitors drive oncogenic transcription, but that their transcriptional targets are highly diversified. Whereas PME-1 controls RAS and MYC-driven transcription, SET controls TP53 targets and G2/M checkpoint genes. We further provide evidence that these nuclear PP2A inhibitors significantly differ in their roles in regulating DNA methylation. Collectively the results indicate that epigenetic protein complexes involved in oncogenic gene expression constitute a significant point of convergence for RAS hyperactivity and PP2A inhibition in cancer. Further, the results provide a rich source for future understanding of phosphorylation as a previously unappreciated layer of regulation of epigenetic gene regulation in cancer, and in other RAS/PP2A-regulated cellular processes.
 Citation Format: Mukund Sharma, Anna Aakula, Francesco Tabaro, Henrik Honkanen, Jesse Kamila, Matthieu Schapira, Cheryl Arrowsmith, Matti Nykter, Jukka K. Westermarck. RAS and PP2A activities converge on phosphoregulation of epigenetic complexes in cancer. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4727.


TWO METHODS OF ASCERTAINING THE LEVEL OF SERVICE OF SIGNALIZED INTERSECTIONS ARE ANALYZED AND A THIRD IS PROPOSED. THE 1965 HIGHWAY CAPACITY MANUAL UTILIZES VEHICLES PER HOUR OF GREEN AS AN INDICATOR OF THE LEVEL OF SERVICE, WHILE A 1962 DESIGN PROCEDURE RELIES ON THE PERCENTAGE OF CYCLE FAILURES, I.E., THE RELATIVE NUMBER OF CYCLES DURING WHICH ARRIVALS, IN A POISSON MANNER, EXCEED THE CAPACITY FOR DEPARTURES. IT IS SHOWN THAT THE TWO INDEXES HAVE A VARYING RELATIONSHIP. CONVERSION CHARTS AND TABLES ARE DEVELOPED. FOR A CONSTANT SERVICE LEVEL, A LOW APPROACH VOLUME WILL ALLOW HIGHER FAILURE RATES THAN MAY BE TOLERATED FOR HIGH VOLUMES. IN ADDITION, THE FEASIBILITY OF EMPLOYING AVERAGE INDIVIDUAL DELAY AS AN INDEX OF SERVICE LEVEL IS EXAMINED. IT IS FOUND THAT FAILURE RATE AND INDIVIDUAL DELAY ALSO HAVE A VARYING RELATIONSHIP. USING CONSTANT DELAY LINES, HIGHER FAILURE RATES WERE ALLOWED FOR HIGH VOLUMES. A COMBINED PLOT OF SERVICE LEVEL AND DELAY INDICATES AN APPARENT DIVERGENCE OF LINES, WHICH IS TAKEN TO SHOW THAT ALTHOUGH AN INTERSECTION MAY SATISFY HCM CRITERIA, INDIVIDUAL DELAY MAY VARY CONSIDERABLY DEPENDING ON ARRIVALS, CYCLE LENGTH, AND LENGTH OF GREEN TIME. A DISCUSSION OF THE PAPER BY THREE OTHER PERSONS FOCUSES ON THE APPARENT MULTIPLICITY OF CHOICES FOR EVALUATING AND DESIGNING INTERSECTIONS. /AUTHOR/


The purpose of this business plan is to determine the commercial, administrative and financial feasibility to implement a company dedicated to the production and sale of handmade furniture made of recycled tires in Quito. The legal constitution of the company is planned as an Anonymous Society, this is regulated in Article 143 of the Company Law, composed of two members, located in the north of Quito.
The company belongs to the furniture industry, in the manufacture of furniture of other materials and parts (except ceramic, concrete or stone) for any use as garden chairs and seats whose code is in C3100.04 in International Standard Industrial classification (CIIU4), the industry shows an average growth of 12% over the past 5 years. The marketing strategy to be used is the differentiation in order to provide a differentiator to have an active role in society to reduce the environmental impact through furniture. All this will be supported with communication campaigns and advertising, participation in
exhibitions and fairs furniture that contribute to product positioning. The market potential of this business are men and covered women between 20 and 64 years of age within the DMQ in urban areas, who belongs to middle class, they seek a type of modern and comfortable furniture, they have an interest of environmental care. This was determined through quantitative and qualitative research markets.


Lubricant for metallurgical powder compositions, comprising 10-60% by weight of a poletileneter is a polyethylene glycol or a poly (ethylene oxide) with the remainder being an oligomeric amide having a weight average molecular weight of at least 1000 g / mol.


What looks like political inactivity may be a careful political strategy, Joao Augusto Neves says, but warns that while the administration waits for political capital to accumulate, political capital is also being spent — and the clock is ticking.


For discrete-time Markov jump linear systems,an optimal control problem is studied.First,a quadratic cost function is determined,and then the optimal controller and Riccati difference equation are designed under complete states information,which are based on Bellman stochastic dynamic programming and the characters of Markov jump systems.Then the method is further extended to incomplete states information.The optimal control algorithm is presented based on a posterior probability density function deciding by observation vector.Finally,an example with incomplete states information is given to verify the effectiveness of the presented optimal controller.


We study in the paper the advection/ diffusion problem in one and two dimension. We use analytical and arithmetical solutions to solve the air pollution problem.


The Gwamba language belongs to the South-Eastern Branch of the Bántu family of languages, according to Dr. Bleek's system of classification. But this language was never known, under its true name, until the Swiss missionaries settled among the Ma-Gwamba people and studied their language. In his Comparative Grammar Dr. Bleek calls it by the name of Tekeza; and, complaining of the scanty materials which he could get, he says (§ 32): "Tekeza dialects are known to us only through short vocabularies."