This paper readdresses the question of whether temporarily higher uncertainty can lead to recessions. In particular, it is studied whether the dynamics induced by uncertainty shocks differ depending on whether they apply to demand conditions or to TFP. To answer the research question a partial equilibrium model that features heterogeneous firms, uncertainty shocks and various forms of capital adjustment costs is built and simulated. The central finding of the paper is that while uncertainty shocks to demand cause the bust, rebound and overshoot dynamics reminiscent of recessions, uncertainty shocks to TFP are likely to lead to large and persistent booms. This result can be easily understood when considering that uncertainty shocks in the model have an expectational effect as well as a distributional effect. While the expectational effect is negative in the presence of non-convex adjustment costs, it's magnitude does not change much between uncertainty shocks to demand and TFP. In contrast to this, the distributional effect is positive and an order of magnitude larger for uncertainty shocks to TFP than for uncertainty shocks to demand. The intuition is that for TFP shocks the revenue function is likely to have increasing returns to scale while for demand shocks the returns to scale can be constant at best. Hence, for TFP shocks higher ex-post cross-sectional dispersion is a time of opportunity which more than compensates for the negative expectational effect of uncertainty shocks, causing a prolonged boom in aggregates. For uncertainty shocks to demand the negative expectational effect dominates the distributional effect causing the recession like dynamics emphasized by Bloom (2009).


atalysis is of vital importance in our society and constitutes a cornerstone of life from biological processes to large-scale production of bulk chemicals. The availability of plentiful and inexpensive chemicals relies on industrial catalytic processes. Other technologies also depend on catalysis, including production of pharmaceuticals, means of environmental protection, and production and distribution of sustainable energy. Much technological advancement required to render alternative energy carriers to fossil fuels an economically viable option (such as sun light and hydrogen) relies on optimizing a catalytic process. For instance, for water to be split into hydrogen and oxygen with sunlight to feed a fuel cell, researchers need to improve the activity of the catalyst, for instance TiO2.


In this era of cloud computing, web services based solutions are gaining popularity. The applications running on distributed environment seek new parameters for them to perform efficiently to satisfy end user's requirements. Finding these parameters for increasing efficiency has become a talk of researchers now days. Non functional performance of a web service is described through User dependent QoS properties. These QoS parameters are generally described in WS-Policy in Service Level Agreement (SLA). Usually in web service QoS datasets, web service QoS values are missing, which makes missing value imputations an important job while working with cloud web services. In the current work we compared the prediction accuracy of two groups of supervised machine learning ensembles based Meta learners: bagging and additive regression (boosting) with a fusion of the seven base learners in both. Random forest is found to be better performing in both Meta learners: bagging and boosting than other learning algorithms.


Objective: To investigate the correlation between the expression of mast cell(MC) as well as tryptase and microvessel density(MVD) in in human thyroid tumor.Methods: Compare with and study the expression of MC,tryptase and CD31 which were examined by histochemistry and PV immunohistochemistry in 116 cases of thyroid carcinoma,56 cases of thyroid adenoma,10 cases of normal thyroid tissues;and analyzed the correlation of the MC,tryptase expressions and the MVD.Results: The number of MC and the expression of tryptase in thyroid tumor tissues were higher than that in normal thyroid,and the number of MC and the expression of tryptase was correlated with the type of tumor(P0.01).Spearman rank correlation analysis showed that the number of MC was positively correlated with the MVD in the thyroid tissues(r=0.900,r=0.636,P0.05).Conclusions: The MC and tryptase may promote to the angiogenesis of thyroid tumor,and so may promote invasion and metastasis of the thyroid tumor.


Resumen en: Even when much nuclear data has been generated during the last 50 years, the need and demand for scattering information of fast neutrons is still a pres...


This article presents the method used for the automatic addition of genre information to the Japanese entries in a Japanese-French dictionary. The dictionary is intended for a wide audience, ranging from learners of Japanese as a second language to researchers. The genre characterization is based on the statistical analysis of corpora representing different genres. We will discuss the selection of genres and corpora, the tool and method of analysis, the difficulties encountered during this analysis and their solutions.


The nuclear quadrupole interaction parameters for the three ()~(14)N nucleus in the ring of RDX have been calculated using the Hartree-Fock procedure. The calculated quadrupole coupling constants for the three ()~(14)N nucleus are 5.671,5.808 and 5.838 MHz,and the asymmetry parameters 0.545,0.560 and 0.564,respectively,approaching the corresponding experimental values(5.675,5.778 and 5.887 MHz for coupling constants,0.608 0,0.638 0 and 0.614 0 for asymmetry parameters). But the order of calculated quadrupole coupling constants of the three ()~(14)N nucleus is different from that of the experimental,and the reason has been analyzed.


Current fire resistance standards for major structural members of buildings require uniform fire resistance performance (in hours). However, buildings may be vulnerable to various local-fire conditions, depending on the industry or business, so it is necessary to examine their differences through simulations. In this study, the existing room corner test (KSF ISO 9705) and simulation results were compared to verify the reliability of the simulations. Next, the similarity of the results was identified. Simulations of actual buildings were performed based on local-fire conditions, and it was verified that the temperature varies by location. Based on the results, it is necessary to focus on performance-based fire resistance design rather than the specification-based design, which requires uniform fire resistance performance in hours. Simulation case studies should be conducted to reflect the diversity of the fire and structural member conditions.


With the launch of TacSat-2, the Operationally Responsive Space (ORS) program has its first on-orbit asset and the ORS community finally gets an opportunity to transition from talking about the benefits of responsive space to demonstrating them. TacSat-2, however, is far from a pure ORS spacecraft and its relevance and utility is far from restricted to the ORS arena. The spacecraft that became TacSat-2 had its origins in a formation flying program called TechSat-21. Though the TechSat-21 program was cancelled, much of the basic spacecraft design survived and reemerged under the name of Roadrunner. Roadrunner was supposed to demonstrate how a militarily relevant spacecraft could be developed and fielded on an accelerated timeframe. It was under-funded from the start and the mission architects solved the financial problem by entering into a number of military, civil, and commercial partnerships. Unfortunately, each partner brought more than money and advocacy -they brought their own sets of experimental hardware and the associated requirements. When the ORS program saw many commonalities between Roadrunner's objectives and their own, they adopted the spacecraft as part of the TacSat ORS program, bestowing upon it additional prestige and the opportunity to become an operational military asset, but further increasing the growing list of mission


Chinese university students shoulder the great historical responsibility of China's cultural heritage and national development.Yet,such phenomena are seen among some graduates during their employment as follows: neglecting the course study of career guidance;modifying too much of their materials for job application;ignoring the contractual relationship between labor and employment,etc.These not only harm the graduate image,but also undermines the interests of employers.Universities need to: grasp the minds of their graduates and guide them properly;promote their sense of responsibility in practice by creating a healthy campus culture;enhance vocational counseling among graduates and strengthening the importance of responsibility consciousness.


This paper, taking the Xinjiang Karamay petrochemical industrial park as the research object, taking growth potential, potential structure, strength potential, management potential and years for land availability as the research content, estimates the potential of intensive land use and research the situation of intensive land use through field survey. By calculation and analysis it is found that intensive land use potential in the park mainly focuses on the potential for expansion and strength potential. The exploration of potential of intensive land use need to start from the optimization of land use structure, investment increase and improvement of output efficiency.


Combined with practice example,it is discussed that for a mid-or small-scale hydropower station upgrade project,when the new runner to be adopted does not completely coordinate with the old water passage,we shall properly select or design the structural parameters of runner to obtain the best matching between new runner and old water passage.


Fish diseases pose a universal threat to the ornamental fish industry, aquaculture, and public health. They can be caused by many organisms, including bacteria, fungi, viruses, and protozoa. The lack of rapid, accurate, and reliable means of detecting and identifying fish pathogens is one of the main limitations in fish pathogen diagnosis and disease management and has triggered the search for alternative diagnostic techniques. In this regard, the advent of molecular biology, especially polymerase chain reaction (PCR), provides alternative means for detecting and identifying fish pathogens. Many techniques have been developed, each requiring its own protocol, equipment, and expertise. A major challenge at the moment is the development of multiplex assays that allow accurate detection, identification, and quantification of multiple pathogens in a single assay, even if they belong to different superkingdoms. In this review, recent advances in molecular fish pathogen diagnosis are discussed with an emphasis on nucleic acid-based detection and identification techniques. Major features and applications of current predominant methods and promising methods likely to impact future fish disease control and prevention are outlined. Introduction Diseases caused by fish pathogens, including bacteria, fungi, viruses, and protozoa, can cause considerable economic losses to the ornamental fish and aquaculture industries. Biosecurity (pathogen preventing) programs that address aquatic animal pathogens and diseases are becoming an increasingly important focus of these industries (Scarfe et al., 2006). Nevertheless, the lack of rapid, accurate, and reliable means by which fish * Corresponding author. Tel.: +32-15-305590, fax: +32-15-305599, e-mail: email@example.com † These authors contributed equally to this work.


Language is primarily constituted by action and interaction based on sensorimotor information. This paper demonstrates the nature of subjectivity and intersubjectivity through the neural mechanism and typological evidence of sentence-final particles from East Asian languages and extends to the discussion of the relationship between them. I propose that intersubjecivity is a kind of embedded or nested interpersonal synergy grounded in mirror neurons. By means of shared motor information and embodied simulation, one's self models can be generated in which other self-models are embedded. With the process of embedded interpersonal synergies, the relationship between synergies might be concerned to produce mutual shaping of meaning between speaker and hearer. Accordingly, I propose a hypothesis that the more intersubjective markers a language has, the more embedded or nested interpersonal synergies it has. This proposal opens new perspective on the understanding of the nature of language communication and (inter)subjectivity. © 2017 IJSCL. All rights reserved. PhD, Email: firstname.lastname@example.com Tel: +86-216-4321630 a Shanghai Normal University, China ARTICLE HISTORY: Received December 2016 Received in revised form February 2017


We demonstrate the formation of highly ordered C60 molecular wire arrays with 2.31 nm interwire spacing by manipulating the intermixed phase of C60 and α-sexithiophene on Ag(111) surface. Our in-situ LT-STM results show that the delicate balance between molecule-molecule and molecule-substrate interactions facilitates the assembly of C60 into well-ordered molecular wire arrays. Due to the large inter-wire spacing and unique molecular structure, the C60 wire arrays could have useful electron transport properties or be used for 2D or 1D quantum confinement of surface electronic states. Objective Well-ordered two-dimensional molecular nanostructure arrays have potential uses in molecular electronics, solid-state quantum computation and biosensors. One of the challenging tasks is to effectively engineer the functional molecules into well-ordered nanostructure arrays. Surface nanotemplate-assisted molecular assembly represents a versatile approach towards the design of molecular architectures with high periodicity. SrTiO3(001)-(6x8) "waffle" surface Fullerene molecules fit in the "waffle" sites PTCDI–melamine honeycomb network Fullerene fit in the honeycomb network Well-ordered 2D template Dominant molecule-substrate interaction Nature 424, 1029 JACS 128, 13976


Geographical representations of topographical space come in many shapes and are a regular topic of discussion. The depiction of the invisible and maybe even illusory concept of time on the other hand, remains largely unchanged and undisputed. A uniform and arithmetic model of time fits well with the rigid structure of digital data, which might be why it has been widely adopted within HCI. In our proposal, we will present historic and contemporary approaches that offer alternative perspectives on the visual representation of time.

Keywords: timeline, chronographics


This paper analyzes efficiency in a uniform-price multi-unit auction with a positive reservation price. I demonstrate that the reservation price is an important policy tool that may increase efficiency (or welfare) in multi-unit uniform-price auctions. I show that the higher the reservation price is, the higher is the seller's revenue and the higher is the efficiency of a final allocation of units that could be attained in a multi-unit uniform-price auction. The reservation price increases the bidder's equilibrium strategy in a specific way that is inherent to the uniform-price auction. Thus the reservation price effect on efficiency is in contrast to other auction formats; e.g., the reservation price decreases efficiency in the Vickrey auction and single-unit auctions with symmetric bidders. Therefore the main result can be added to the list of results from mechanism design and auction theory that fail to extend the single-unit/single-dimensional context to the multi-unit/multi-dimensional one.


Background: Randomized clinical trials (RCT's) of novel treatments for solid tumors typically measure disease progression using the Response Evaluation Criteria in Solid Tumors (RECIST) with precisely timed patient assessments relative to treatment administration. However, outside of RCTs, patient assessments are not precisely timed, uniformly documented or manually curated, introducing difficulties in deriving cancer outcomes using real-world data (RWD). Novel informatics-based approaches to estimate cancer outcomes are needed to advance the use of RWD for facilitating rigorous cancer research. The goal of this study was to report on current methodologic approaches to measure (or approximate) real-world (RW) disease progression using lung cancer as an illustrative example.
 Methods: A methodical literature review was conducted using PubMed to identify approaches to estimate/approximate RW-progression among patients with lung cancer. Between 2008-2022, a total of 40 articles were identified relating to the estimation of lung cancer RW-progression. Data abstracted during the review included data source type, approach used to estimate RW-progression, and whether the RW-endpoints were compared to a gold standard, and how the gold standard was defined.
 Results: Data sources used to estimate RW-progression within the various methods included clinical notes, medication information, pathology/radiology reports, and radiological images. A total of five different methods to estimate RW-progression were identified from the search results, including studies reporting manual abstraction (n=17), treatment-based algorithms (n=6), natural language processing (n=4), algorithms based on changes in tumor volume (n=7), and radiomics (n=6). Comparisons of RW-progression endpoints to a "gold standard" were used by 50% of studies although the definitions of the gold standard varied across studies. As a final step, a comparison of the RW-progression endpoints will be presented.
 Conclusions: A substantial amount of literature exists relating to methods for curating RW-disease progression in patients with lung cancer. However, comparison of methods and results across studies is challenging due to the lack of a consistent gold standard. Furthermore, no studies assessed a variety of methods within the same lung cancer patient population. Studies are needed that compare several methods within the same patient population in order to identify an optimal method for estimating RW-progression with high effectiveness and accuracy. Lastly, concerted efforts are needed to define a gold standard and quality metrics for RWD.
 Citation Format: Rossybelle P. Amorrortu, Yayi Zhao, Matthew B. Schabath, Dana E. Rollison. Informatics-based and other approaches to estimate real world disease progression in lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 943.


of final paper, summarizing the results in detail: We have made BeppoSAX observations of the Seyfert 2/1.9 galaxy ESO103-G35, which contains a nuclear maser source and is known to be heavily absorbed in the X-rays. Analysis of the X-ray spectra observed by SAX in October 1996 and 1997 yields an energy index = 0.74+/-0.07, typical of Seyfert galaxies and consistent with earlier observations of this source. The strong, soft X-ray absorption has a column density, N_H of (1.79+/-0.09)E23 cmE-02, again consistent with earlier results. The best fitting spectrum is that of a power law with a high energy cutoff at 29+/-10 keV, a cold (E=6.3+/-0.1 keV, rest frame), marginally resolved (o = 0.35+/-0.14 keV, FWHM -(31 +/12)E03 km/s) Fe Ka line with EW 290 +100 -80 eV (1996) and a mildly ionized Fe K-edge at 7.37 +0.15 -0.21 keV, tau 0.24 +0.06 -0.09. The Fe Kot line and cold absorption are consistent with origin in a accretion disk/torus through which our line-of-sight passes at a radial distance of-0.01 pc. The Fe K-edge is mildly ionized suggesting the presence of ionized gas probably in the inner accretion disk, close to the central source or in a separate warm absorber. The data quality is too low to distinguish between these possibilities but the edge-on geometry implied by the water maser emission favors the former. Comparison with earlier observations of ESO 103-G35 shows little/no change in spectral parameters while the flux changes by factors of a few on timescales of a few months. The 2--10 keV flux decreased by a factor of-2.7 between Oct 1996 and Oct 1997 with no detectable change in the count rate >20 keV (i.e. the PDS data). Spectral fits to the combined datasets indicate either a significant hardening of the spectrum (energy index -0.5) or a -constant or delayed response reflection component. The high energy cutoff (29+/-10 keV) is lower than the typical -300 keV values seen in Seyfert galaxies. A significant subset of similar sources would affect current models of the AGN contribution to the cosmic X-ray background (CXRB) which generally assume a high energy cutoff of-300 keV. Publications to date on this project: • SAX Observations of the Maser AGN ESO103-G35 Wilkes, B.J., Mathur, S., Fiore, F. & Antonelli, A. BAAS 30, 842 • SAX Observations of the Maser AGN ESO103-G35. Wilkes, B.J., Mathur, S., Fiore, D. & Antonelli, A. in "" Structure and Kinematics of Quasar Broad Line Regions" eds.C.M. Gaskell,W.N.Brandt,D. Dultzin-Hacyan,M. Eracleous& M. Dietrich, ASPConferenceSeries,in press TheBeppoSAXObservationsof theSeyfert 1.9GalaxyESO103-G35, Antonelli, A., Wilkes, B.J.,Fiore,F.,Matt, G., Mathur,S.& Nicastro,F., in Proceedingsof the3rd IntegralWorkshop,Sicily, 14--18Sept1998, in press BeppoSAXObservationsof theMaserSy2Galaxy:ESO103-G35Wilkes, B.J., Mathur,S.,Fiore,F., Antonelli, A., Nicastro,F., ApJ, 549,248 _'t-_ ASTROPHYSICAL JI3UI12qAL, 549:248-253, 2001 March 1 "J_'_ © 2001. The American Astronomical Society. All fights reserved. Printed in U.S.A. BEPPOSAX OBSERVATIONS OF THE MASER SEYFERT 2 GALAXY ESO 103-G35 BELINDA J. WILKES, 1 SM1TA MATHUR, 1'2 FABRIZIO FIORE, 3'4 ANGELO ANTONELLI, 3'4 AND FABRIZIO NICASTRO1 Received 2000June 28; accepted 2000 October 23


Two mapping populations were developed to detect the genic male sterile genes,respectively.The F2 mapping population for Zheng 58 mutant was developed by crossing the Zheng 58 sterile plant 5280(ms) with the Zheng 58 fertile plant 5280(Ms) obtained through several generations of sub-matting.While the F2 mapping population for Chang 7-2 mutant was obtained by crossing the Chang 7-2 sterile plant 8057(ms) with a normal male fertile maize inbred line Huang C.The two F2 populations included 128 and 146 plants,respectively.For the Zheng 58 population,35 complete sterile plants and 93 complete fertile plants were observed.For the Chang 7-2 population,32 complete sterile and 114 complete fertile plants were observed.The results of χ2 tests showed that they were all accorded with the segregation ratio of 3∶1.According to the male fertility observed in the field experiments and BSA method,polymorphism analysis was conducted using 418 and 386 pairs of SSR primers for the two F2 populations,which were distributed in the 10 chromosomes of maize.Totally 17 and 36 pairs of SSR primers with polymorphism were found,respectively.These polymorphic primers were further used to detect the genotypes of each F2 plant.Linkage analysis showed that the two male sterility genes were located on chromosome 1 and 4 for Zheng 58 and Chang 7-2 mutants,respectively.SSR markers phi 427913 and umc 1160 were linked with the male sterility gene in the Zheng 58 mutant,and their genetic distances from the male sterility gene were 23.8 and 19.4 cM.However,the male sterility gene in the Chang 7-2 mutant was linked with phi 006 and umc 1109,with their respective genetic distance of 18.0 and 26.3 cM.


AbstractThis study aims to describe the forms and types of conversational implicatures in the 2020 Sambas Regent and Deputy Regent Candidate Debate. The research method used is descriptive with a qualitative research form. The data from this study are declarative sentences, imperative sentences, introgative sentences, general and specific conversational implicature in the 2020 Sambas Regent and Deputy Regent Candidate Pair Debate. The source of data was taking from the 2020 Sambas Regent and Deputy Regent candidate pair debate which is broadcast through the Sambas Regency Comunications and Information Agency youtube page which was broadcast live on November 21, 2020, lasted 3 hours 26 minutes 25 detik. The data collection technique in this research is a documentary study technique. Based on the results of the analysis in the 2020 Sambas regent and Deputy Regent Candidate Debate, it can be concluded that there are 23 forms af declarative implicature sentences, 21 forms of interrogative implicature sentences, 41 forms of imperative implicature sentences, 7 forms of general conversational implicature sentences, and 78 specific conversational implicature sentences. In addition, this research can also be used as teaching material in learning Indonesian for grade X second semester in senior high school level as the debate material.Keywords: Conversational Implicature, Debate, Implicatur


We got vary data about neuron-threshold from animal experiment. We try to find the disciplinarian from the data in order to confirm something. In this article we first confirmed unitary method of neuron-threshold; and then found t he complication working on the neuron-threshold parameter and the connection bet ween one another; at last proved the non-linear characteristic about neuron. The se conclusions do well to the clinic application of nerve electro-physiology; ne rve biology and neuron-threshold. Along with the experiment data enriched and co nsummated more and more, using analysis method for experiment, neuron-threshold will be up to par of clinic diagnosis and treatment.


We report on the development of an electrically controllable superconducting phase shifter suitable for operation in a terahertz heterodyne receiver. The key physical principle of operation, and that of nonlinear kinetic inductance, is developed into a device theory and also appropriate design rules. Critical figures of merit are then identified and optimized designs presented. Experimental tests of prototypes are described that were used to help further refine the design rules. Although a practical phase shifter was not produced, the prospects for the device concept appear good.


SYNOPTIC ABSTRACT The aim of this article is to present a fuzzy programming approach to a single-sink, fixed-charge, multiobjective, multi-index stochastic transportation problem (SSMISTP). This article focuses on the minimization of the transportation cost, deterioration rate, and underused capacity for transportation of raw materials from different sources to the "Single-Sink" by different transportation modes. The parameters of the proposed problem are transportation cost, fixed-charge, deterioration rate, and underused capacity. These parameters are to be treated here as random variables. Because of the globalization of the market, assume that the "Sink" demand is an interval representing the inexact demand component for the SSMISTP. By considering the uncertainties of these parameters, we formulate the mathematical model of the proposed problem. Using a stochastic programming approach, all the stochastic objective functions are converted into deterministic objective functions. Again using the interval concept, the proposed interval-valued sink constraint decomposes into two deterministic constraints. Finally, using all deterministic objective functions and constraints, we design a multiobjective transportation problem(MOTP). The optimal compromise solution to the MOTP has been obtained by using a fuzzy programming technique. We demonstrate the feasibility of the proposed problem using a real-life practical example.


In this paper,Applicaltions of potassium titanate whiskers are introduced in details. The status of whiskers technology at home and abroad are reviewed.And the domestic market prospects of whiskers are discussed.The studies of reducing the cost of potassium titanate whiskers is one of the important topics in the future.


As Kar l ' s In tegra ted M a t h e m a t i c s I teacher n o t e d , K a r l is s h o w i n g α pre fe rence (o r w o r k i n g independent l y , especia l ly o n activities in w h i c h h e feels c o m f o r t a b l e . A s is feas ib le , incorpora te p revocar iona l a n d life skills concepts (i.e., funct ional skills) into his curr icu lum. F o r e x a m p l e , discuss h o w read ing recipes a n d us ing fract ions o r e necessary in c o o k i n g ; note that add i t i on a n d spel l ing o r e used in b a n k i n g skills. Such concepts wi l l he lp h im in gene ra l i za t i on skills a n d wi l l connect Ka r l to adu l t p r e p a r a t i o n activit ies. In α mee t ing w i t h Kar l 's parents a n d school staf f , w e c a m e u p w i t h α p l an to ensure cont inu ing success f o r this s tudent in α paroch ia l h igh school inclusion p r o g r a m . T h e p reced ing r e c o m m e n d a t i o n addresses the ind iv idua l needs o f this s t uden t—bu t requ i re ex tens ive t ime a n d e f for t f r o m the profess ionals i n v o l v e d . This is o n e lesson lea rned in a n inclusion p r o g r a m estab l ished w h e n severa l parents o f y o u n g p e o p l e w i t h disabi l i  ties expressed their vtnsh that their chiklren rema in in paroch ia l x h o o l v ^ e n they reached h igh school a g e . This art icle no t o n l y chronicles the first y e a r o f the p r o g r a m a n d d e  tails the s u p p o r t p r o v i d e d b y consul tants, staff m e m b e r s , a n d admin is t ra to rs , bu t is a lso α tes tament to the pa ren t s ' cont inual i nvo l vemen t in their chi ldren's educa t i on .


The bifunctional human soluble epoxide hydrolase (sEH) is implicated as a regulator of diverse physiological processes due to the brakedown of arachidonic acid derived signalling molecules like epoxyeicosatrienoic acids (EETs) by its epoxide hydrolase domain. Recently, we discovered that the sEH N‐terminal domain displays a novel phosphatase activity. sEH accepts the generic substrate 4‐NPP as well as lipid phosphates, but the physiological role remains uncertain.


The so-called Internet Studies have highlighted the importance of pedagogy declined as a philosophy of education, as a science able to provide, together with other social and cultural sciences, a significant contribution to the understanding of the implications and educational potential of the Net in the age of infosphere. Over the past few years, the so-called social networking pedagogy has emerged as an interdisciplinary approach focusing on curriculum and training. It is a pedagogy that identifies in the interaction that takes place, for example, in social networks (containers for communicative interaction) the possibility of developing a learning and training model that not only opens up new scenarios for education of the future through new media but also allows to understand critically the whole contemporary culture. Therefore, starting from the analysis of this scenario and using a theoretical methodology based on mainly hermeneutical-deconstructive and historical-dialectical approaches, the article outlines the possible epistemological framework for the networking pedagogy within the Internet studies, and identifies its main issues. The authors highlight how this specific pedagogy develops today as a pedagogy of culture characterized by a positive and optimistic approach to the new media (with particular reference to social networks). After identifying the advantages and disadvantages of the new media, such a pedagogy intends to consider pedagogical issues that teachers and trainers have to focus on and transform into effective educational communication content and tools for the curriculum. The article examines the contributions of the critical pedagogy scholars David Trend and Henry Giroux who can be considered the pioneers of networking pedagogy. The article concludes by highlighting the importance of ethics as a pedagogical practice that, through control, regulation and supervision of communicative interactions in social networks, paves the way for their conscious and educational use.


Data on attaining indicators of early speech, language, and literacy development, notably phonological awareness, among children with visual impairments (VI) are limited. This study utilized the National Survey of Children's Health (NSCH), 2016–2020, to observe the distinctive population of children with VI and speech, language, and literacy needs. Chi-square bivariate and multivariable logistic regression analyses established differences between children ages 3 to 5 with VI ( n = 186) and without VI ( n = 25,354). Significant differences included lower parental education and higher rates of family poverty for children with VI. Significantly fewer children with VI had attained early phonological awareness (identifying initial sounds in words and word rhyming). Nearly three times more children with VI had been diagnosed with a speech or language disorder. Findings affirm that interventions address speech, language, and literacy development among children with VI, including explicit phonological awareness. Communication disorders research based on population health databases can inform evidence-based practice.


We have observed a persistent increase in the expression and activity of the immunoproteasome (iProt) in post‐ischemic heart (post‐MI). The objective of this study was to identify the pathway and mediator(s) responsible for iProt upregulation. Using RT‐PCR, ifng, tnfa, and ifnb1 mRNAs were assayed. There were no changes in either ifng or tnfa but ifnb1 was elevated ~ 17‐fold (P<0.01) in the heart 4 days post‐MI. Exposure of a mixture of rat neonatal cardiomyocytes/fibroblasts (CM/CFs) to IFN‐β from 1U/ml up to100u/ml for 24h resulted in a variable response with an 85% (P<0.05) increase in iProt at 100 u/ml as measured using the ProCISE assay. Since the CM/CF preparation typically contains about 20% cardiac fibroblasts, (confirmed by vimentin staining), isolated CFs were exposed to IFN‐β for 24hs which resulted in a robust concentration‐dependent increase in iProt that was almost 3‐fold (P<0.01) at 100 u/ml. An enriched CM (eCM) preparation in which CFs were limited to ≤5% was prepared and these had the lowest iProt response to 10u/ml IFN‐β (eCM, +27% ± 5%; CF, +104 ± 15%; CM/CF, +52 ± 18%). To determine a potential source of IFN‐β in the post‐MI heart, CFs, CM/CFs and eCMs were exposed to 1% O2 for 22h to simulate ischemia. This resulted in +2 ±1%, +31 ± 8% (P<0.05), −16 ± 5% changes in iProt, respectively, suggesting that the CMs were the source of the IFN‐β. RT‐PCR analysis revealed that ifnb1 transcription in the control and in hypoxic eCMs was increased 2.75‐fold (P<0.01) and 3.3‐fold (P<0.01) respectively when compared to hypoxic CM/CFs. To probe a potential function of IFN‐β, CM/CFs were pretreated with 100 u/ml IFN‐β 24h prior to exposure to hypoxia (1% O2) for 22h. Cardiomyocyte injury was determined using protein array to measure release of cardiac injury markers, cTNI, cTNT and FABP3, into the media. All of the markers were significantly increased at the end of the hypoxic challenge in cells that were not pre‐treated with IFN‐β as compared to controls. In the absence of hypoxia, IFN‐β had no effect on the levels of these markers. However, when IFN‐β pre‐treated CM/CFs were exposed to hypoxia there was a significant reduction (P<0.05) in all three markers as compared to hypoxic CM/CFs alone. These results suggest that in response to hypoxia CMs release IFN‐β which then stimulates CF to upregulate an iProt that serves to protect CMs. Overall, these studies suggest the existence of a previously unrecognized signaling pathway in the heart involving CM IFN‐β signaling to the cardiac fibroblast.


This paper establishes a 3D finite element model of a new-type metal-cooled fast reactor (MCFR) nuclear island plant for applied research of base isolation technology, and the research includes the base isolation scheme for the split base layer structure, the selection from different types of isolation bearings, etc. According to the mechanical characteristics of different isolation bearings and rigidity distribution of the structure itself, the layout of isolation bearing scheme is carried out. Dynamic analysis of nuclear plan has been done based on ANSYS, and the optimal isolation scheme is determined by repeated trial calculation, isolation design schemes adjustment, acceleration and displacement of key nodes comparison. The results show that: applying base isolation design to the nuclear island plant, natural vibration period of the structure increases, acceleration response of the key nodes of the superstructure and displacement between the layers of the structure significantly decreases, seismic resistance of the nuclear island plant is improved significantly; isolation effect of the scheme with multiple types of isolation bearings is much better than that of the scheme with only rubber bearings.


Characterization of colorectal neoplasia with Kudo's [1] and Sano's patterns [2] distinguishes superficial neoplasia (submucosal invasion <1000μm) displaying Kudo Vi and/or Sano 3a patterns from deep invasive cancers (DIC) (> 1000μm) that display Kudo Vn or Sano 3b patterns. Endoscopic submucosal dissection (ESD) is a curative treatment for T1 colorectal cancer with submucosal invasion when the tumor does not display budding, lymphovascular invasion and poorly differentiated components, but depth of invasion over 1000μm is not an independent risk factor of lymph node metastasis [3]. This leads to a new challenge to distinguish lesions with deep submucosal invasion, which are potentially treatable with ESD, from T2 cancers, for which ESD is unfeasible and dangerous since the submucosa disappears below the lesion. Waiting for optical criteria, Japanese experts have proposed attempting ESD with diagnostic intent [4] to obtain, if successful, a precise pathology evaluation (risk factors) to guide further management. Herein, we present images of a 4-cm nongranular laterally spreading tumor in the left colon in a 63-year-old woman, displaying a 10-mm area with disrupted vessels (Sano 3b) and amorphous pit pattern (Kudo Vn) at the center of the lesion (▶Fig.1). We attempted diagnostic ESD with targeted submucosal tunneling to explore first the area suspected of deep invasion (▶Video 1). Once we reached it, we were able to confirm tumor invasion through the submucosal space as far as the muscularis propria. Examinations inside and outside the tunnel confirmed the correspondence of the areas (▶Fig. 2). Biopsy samples from the tunnel confirmed adenocarcinoma in the area of invasion. ESD was stopped without risking perforation and further surgery revealed T2 adenocarcinoma. E-Videos


In a modern automobile assembly line, kanban cards or e-kanban cards are used for parts supply. In the line, if a worker would assemble incorrect part to a car body, an inferior product may be shipped to the following production process. Such inferior products will be caught at the inspection process however suspension of production line will occur. In this paper, we propose a loss detection model for a work station which requires installing certain parts. Relationship between number of conveyed car bodies and consumed parts are compared to detect the loss, where we use kanban cards to count parts consumption. We present mathematical models to detect losses and some numerical examples to show stochastic performance of the proposed loss detection model.


NURSES ARE being overruled by cash-strapped social services departments over decisions on whether older people need nursing care, nursing home owners have claimed.


This article describes the urgency to address climate change risks. One message is that the focus on mitigation and adaptation alone will not allow to reduce climate change risks with the time left before we reach potential tipping points of the climate system. The article therefore has a focus on additional approaches such as carbon dioxide removal (CDR) by technologies that can be upscaled to limit overshooting to a reasonable period of time (several decades) and approaches to avoid further warming by use of solar radiative management (SRM) approaches to buy time before CDR will have done its job. As a first step with respect to governance, principles that could be the basis for requirements are suggested, based upon recently developed documents in the private and voluntary domain to address greenwashing in the context of carbon neutrality/net zero carbon claims.


Success in spoken word processing relies not only on accurate word recognition but also the veracity with which words are maintained in memory. However, research on word retention is still scarce, especially in tonal languages and phonologically impaired populations. To address these gaps, the present study administered an auditory order recall task to native Cantonese speakers with and without amusia. Stimuli intrinsic (segmental similarity, suprasegmental similarity, and lexicality) and extrinsic (cognitive load) factors were manipulated. As expected, word recall was significantly impaired by increased cognitive load, and, similar to the retention of non-tonal languages, rime similarity exerted opposite effects on Cantonese real and pseudo word recollection. However, no reversal was observed in the suprasegmental dimension: Lexical tone similarity was persistently detrimental to recall accuracy. Tonal similarity Effects were also more robust against increased cognitive load than segmental similarity effects, implying differential weighting of suprasegmental and segmental cues in spoken word retention. These results are consistent with the view that distinct processing mechanisms exist for segments and tones. Besides, this study found it useful to combine accuracy and response time analyses. The potential of the combined analysis to capture the nature of phonological deficits is discussed in relation to amusia.


The crankshaft is one of the most important components of engine, it endures complex and alternate load and it is the key point and difficuty of the engine design. Dynamic characteristics of crankshaft has been abstractly analyzed its kinematics and dynamics. A model of crank-cinnecting rod mechanism had been built in the software of Pro/E and ADAMS. To get the minimum force acted on mounting base, structural feature, velocity and quality of the mechanism have been parametric and optimal designed. The simulation results shoe that the conform to the theoretical arithmeticresults. The research displayed a convenience and high efficiency method of mechanical design. It will provide some experience for large-scale simulation reseach in the future.


The Yellowstone fires of 1988 produced a mosaic of Pinus contorta stands subjected to fire of varying severities. In August, 1989, we inventoried density of vascular plants in paired plots at seven burned stands. One plot was in a severe canopy bum; the paired plot was in an adjacent area that burned at moderate severity. Density of vascular plants was consistently higher in moderate than in severe burn plots. At all sites, floristic composition largely reflected the species present before the fire. Two-thirds of the individuals present in the first postfire season were from vegetative regrowth of plants that survived the fire; of the remaining third, most were P. contorta seedlings. Fire severity had a strong influence on seedling density; at all sites, P. contorta seedling density was higher in the plot classified as a moderate bum. P. contorta seedling density was not related to that of potential competitors. Within sites, the key variable explaining differences between moderate and severe plots is probably loss of seeds consumed or killed by severe canopy fires; differences among sites are likely a consequence of availability of seeds at the time of the fire, a function of the proportion of serotinous trees in the stand.


The Amendment of UUD 1945 at reform era have brought implication happened change to high institute structure of state. The change influenced by existence of the change of political constellation and political power in Indonesia. Because, constitution influenced by will political from top kick political power at one particular state. By normative- juridical, having implication is existence of change authority had previous Institute State, and there is also Institute new State emerges. By political-sociological, change the constitution influenced by existence of change political constellation and political power in Indonesia Kata Kunci: Konstitusi, Amandemen, Lembaga Negara


This thesis discusses the maximum principle of the solution's functional of the quasilinear parabolic equation at the first initial boundary-value problem.


Background: This study aimed to identify the association of compliance with sick role behavior with satisfaction of basic psychological needs, and to assess the influence of compliance with sick role behavior among hemodialysis patients. Methods: Participants included 109 patients from outpatient dialysis clinics at 6 major general hospitals located in urban areas in Korea. Data for compliance with sick role behavior and basic psychological needs were collected through a self-reported questionnaire and was analyzed with independent t-test, one-way analysis of variance, Pearson' correlation analysis, and multiple stepwise linear regression analysis. Results: This study showed positive correlations between compliance with sick role behavior and satisfaction of basic psychological needs (r=0.59, P<0.001). The variables predicting compliance with sick role behavior were relatedness (β=0.28), autonomy (β=0.29), competency (β=0.30), and age (β=0.24). These variables accounted for 38.2% of the variance of compliance with sick role behavior in hemodialysis patients. Conclusions: Our results indicated that it is necessary to improve compliance with sick role behaviorin order to increase satisfaction of basic psychological needs in hemodialysis patients. Korean J Health Promot 2012;12(1):58-65


1. Writing Scholarly Papers 1a Subject and Topic 1b Thesis Statements, Hypotheses, or Stated Objectives 1c Research Goals 1d Research Methods 1e Evaluating Sources 1f Note-Taking 1g Plagiarism 1h Planning 1i Writing Strategies 2. Preparing Chicago-Style Manuscripts 2a Parts of the Manuscript 2b General Manuscript Guidelines 3. Following Chicago Editorial Style 3a Punctuation and Mechanics 3b General Style 3c Word Choice 4. Preparing Endnotes, Footnotes, and the Bibliography 4a Endnotes and Footnotes--An Overview 4b Placing Note Numbers in the Paper 4c Information for Endnotes and Footnotes 4d Format for Endnotes and Footnotes 4e Positioning Endnotes and Footnotes 4f Multiple Notes from the Same Source 4g Multiple References in the Same Source 4h The Bibliography--An Overview 4i Information for Bibliographic Entries 4j Format for Bibliographic Entries 4k Alphabetizing the Bibliography 4l Specialized Elements of a Bibliography 4m Quotations 5. Preparing Note Forms for Books and Other Separately Published Materials 5a A Book by One Author 5b A Book by Two or Three Authors 5c A Book by Four or More Authors 5d A Book with No Author Named 5e A Book by an Author Using a Pseudonym 5f A Book with an Organization as Author 5g An Edition Other Than the First 5h A Revised or Enlarged Edition 5i A Reprinted Book 5j A Multivolume Work 5k An Edited Collection 5l A Selection in an Edited Collection 5m Multiple References to the Same Collection 5n An Article in an Encyclopedia or Other Reference Work 5o A Work in a Series 5p An Imprint 5q A Translation 5r A Government Document--Congressional Record 5s A Government Document--Committee, Commission, Department 5t A Preface, Introduction, Foreword, Epilogue, or Afterword 5u A Pamphlet or Brochure 5v Published Proceedings from a Conference 5w A Dissertation 5x A Book Written in a Language Other Than English 5y Sacred Writings 5z A Secondary Source 6. Preparing Note Forms for Periodicals 6a An Article in a Journal with Continuous Paging 6b An Article in a Journal with Separate Paging 6c An Article in a Monthly Magazine 6d An Article in a Weekly Magazine 6e An Article in a Newspaper 6f An Editorial or a Letter to the Editor 6g A Review 6h An Abstract from Dissertation Abstracts International 6i A Secondary Source 7. Preparing Note Forms for Audiovisual Sources 7a A Film 7b A Filmstrip 7c A Television Broadcast 7d A Radio Broadcast 7e A Recording 7f A Performance 7g An Interview 7h A Transcript 7i A Lecture or Speech 7j A Work of Art 7k An Exhibit 7l A Map, Graph, Table, or Chart 7m A Cartoon 8. Preparing Note Forms for Electronic Sources 8a An Online Scholarly Project, Information Database, or Professional Website 8b A Source from an Online Scholarly Project, Information Database, or Professional Website 8c An Online Book 8d An Article in an Online Journal 8e An Article in an Online Magazine 8f An Article in an Online Newspaper 8g An Article in an Online Encyclopedia or Other Reference Source 8h An Online Government Document 8i An Online Transcript of a Lecture or Speech 8j An Online Work of Art 8k An Online Exhibit 8l An Online Map, Graph, Table, or Chart 8m An Online Transcript of a Television or Radio Broadcast 8n An Online Audio Source 8o A CD-ROM Source 8p An E-mail Interview 8q An Online Posting 9. Examining a Sample Paper Sample Paper: "Walking into History: The Legacy of the Lincoln Memorial" (Jarah Estes-Cooper) Appendixes A. Parts of the Chicago-Style Paper B. Chicaog-Style Abbreviations C. Sample Pages D. Bibliographic Entries


Objective To establish the normal reference range of peripheral blood T lymphocytes,B lymphocytes and NK cells of healthy adults in Huabei oilfield,and provide the reference for the analysis and research of immune status.Methods BD MultiTEST four-color specific lymphocyte subsets fluorescent antibody was used to mark the 376 cases,BD FACSCalibur flow cytometry was used to detect specific lymphocyte subsets and the results were analyzed using SPSS 13.0 software.Results The reference range of healthy adults lymphocyte subsets in Huabei Oilfeild were as following:817~2 048/μl(43.2%~80.0%)for CD3+ cells,390~1 296/μl(20.0%~51.0%)for CD3+CD4+ cells,242~993/μl(11.2%~42.0%)for CD3+CD8+ cells,78~503/μl(5.0%~19.0%)for CD3-CD19+cells,123~969/μl(6.0%~36.8%)for CD3-CD16+CD56+ cells,0.66~2.85 for CD3+CD4+/CD3+CD8+ ratio.Conclusion The reference value range of peripheral blood lymphocyte subsets of healthy adults can be established in the same area.


We have investigated lasing mechanism for a Nd:YAG laser with cholesteric liquid crystal (CLC) end mirrors. The slope efficiency of a CLC-dielectric mirror resonator was measured and compared with a dielectric-dielectric mirror resonator. We considered influence of nonlinear bleaching of the CLC mirror on the operation of Nd:YAG laser. In cw operation we did not observe any difference in laser output power with a conventional dielectric-dielectric mirrors resonator. When we switched on the operation of laser from cw to 500 ns 4.5 kHz lasing, it disappeared in a 30 s - 10 min time interval, which depends on current on the lamp and the anchoring conditions on the sides of the CLC mirror (we tested four different CLC mirrors). It should be noted that this effect districts the use of the CLC mirrors in high- repetition rate lasers.


The purpose of this study is to investigate that the effect of ingesting conjugated linoleic acid??(CLA) and having combined exercises for 12 weeks to body composition, social physique anxiety and physical??self efficacy of female college students. 20 female students (Group that taken CLA : 12, Group that taken Placebo : 8)??were participated from C university who has Body Mess Index (BMI) over 20, and has no danger in health when??they take combined exercises and CLA. Group of CLA is requied to take a CLA 6 unit 500mg for 12 weeks without??time limitation. in another group with placebo, they were covered with 3.g/day corn oil by same method of CLA.??coordination exercise is consists of warm up, main exercise and cool down for 90 min for 12 week(3 times??per week). Collected data were analyzed by two-way mixed ANOVA, and the results are as follow. First, according??to the results, data was collected by means of both groups had CLA and PLAC were increased about body??weight and BMI after 12 weeks of combined exercise program. Second, according to the results, data was collected??by means of both groups had CLA and PLAC were decreased about physically expressed satisfaction after 12 weeks of??combined exercise program. But both group were increased about negative physique evaluation. Third, according??to the results, data was collected by means of exercise with CLA group were increased about recognized- physical ability, but exercise with PLAC group were decreased. While exercise with CLA group decreased, exercise with??PLAC group increased on physical self efficacy.


Amputation is the separation of part of the body part of the extremity or entirely, it can be said to be surgery with the action of a part of the body. Amputation is the last option when the 'body' extremities can not be cured by any other means. The number of amputation cases that occur causes post amputation patients to experience social isolation and lack of fulfillment of needs, so the need for a solution for patients after amputation. The design of the control system for the robot arm is expected to be a solution for patients with postamputation as a replacement arm. The hand robot designed uses Arduino Uno on its microcontroller and uses a linear motor from Actuonix as its driver. This hand robot works based on the results of EMG signal data processing identified with Myo Armband. All acquired EMG signal data is processed using synergy features and classified using artificial neural networks. System testing was carried out on five healthy people by carrying out three types of movements namely low, medium and strong handheld. And with three different positions, hands straight down (P1), hands rested on the table (P2) and hands stand on the table (P3). Tests are carried out with a windows size parameter of 150 ms, windows increament of 50 ms, synergy features of MAV types with number of synergy 8, and RBF-ELM classification types with gamma values of 0.1 in offline testing and online or real-time testing, with each has an accuracy value of 96.16% in offline testing and 62.88% in online testing.


Growing up in a small farming village in the rural Hudson Valley of New York state, Lillian was recognized as bright and curious. This opened doors for her, including participation in a school enrichment program that unlocked the world of culture and ideas. Monthly field trips to New York City introduced her to opera, art, and the exchange of ideas on contemporary issues by prominent thinkers and scientists. One memorable evening was spent having dinner with Margaret Mead. These experiences lead Lillian to value inquiry and set her on her way to an education at the University of Rochester and a nursing degree. As an undergraduate, she was exposed to research as a vehicle to build knowledge. Lillian made a lifelong connection between her curiosity and research as the means to explore and learn. As a staff nurse, Lillian sought positions where she could care for patients participating in clinical research trials. She eventually worked with a research team involved in the early development of the intra-aortic balloon pump. Out of this experience came her first publication, a coauthored article in Heart & Lung in 1973 about the device. Soon she returned to the University of Rochester for a master's degree in nursing; after she earned this degree, she took a teaching position in a nursing program at a small liberal arts college. Within a year she missed the excitement she felt in the university research environment, and she soon headed back to the University of Rochester to pursue a doctoral degree in nursing.


We study the Cauchy problem for the Laplace equation in a cylindrical domain with data on a part of it's boundary which is a cross-section of the cylinder. On reducing the problem to the Cauchy problem for the wave equation in a complex domain and using hyperbolic theory we obtain explicit formulas for the solution, thus developing the classical approach of Hans Lewy (1927).


Multi-mode fiber (MMF) endoscopes are a new type of endoscope that use only a single optical fiber to transmit images, achieving much higher spatial resolution for a given diameter than commercial fiber bundle endoscopes. However, a drawback of MMF endoscopes is that imaging quality degrades substantially as the MMF is perturbed. We propose a method for improving spot formation at the distal end of a perturbed MMF, and thus improving imaging quality, by attaching a partial reflector to the distal end of the MMF. We experimentally find that the perturbation of the light reflected from the partial reflector is highly correlated with the perturbation of the light transmitted through the MMF. We demonstrate a simple method exploiting this correlation that enables formation of spots at the distal fiber end with quality 10-15% higher than if the perturbation of the MMF is ignored. In the future, more advanced algorithms exploiting the correlation may enable further improvements in spot formation and imaging through perturbed fibers.


Objective
To investigate the clinical manifestations in patients with 22q11.2 deletion syndrome (22q11.2DS) to improve the understanding of the disease.

Methods
Twenty patients with 22q11.2 DS were enrolled from Children's Hospital of Fudan University between August 2008 and April 2014.Cytogenetic and molecular genetic methods included fluorescence in situ hybridization (10 cases), and multiplex ligation-dependent probe amplification (10 cases). Age at the time of the diagnosis, sex and clinical manifestations were analyzed.

Results
The subject group consisted of 20 patients.Among them, 13 cases (65%) were male and 7 cases (35%) were female.The median diagnostic age was 3.9 months.The presence of congenital heart diseases was identified in 17 patients (85%) and surgical correction was performed in 9 cases of them.The most frequent of complex congenital heart diseases were tetralogy of Fallot (20%) and pulmonary atresia (20%). Ten patients had varying degrees of T-cell immune function defects.Decrease in total lymphocytes and only CD8 counts were present in 45% and 5%, respectively.Hypogammaglobulinemia was not detected in any patient.Six cases with T-cell immune function defects were treated with thymosin, 4 of which were followed up for months, and the prognosis was good.Hypocalcemia was detected in 6 patients(30%), 3 of whom presented with hypocalcemic seizures and hypoparathyroidism.Craniofacial dysmorphisms were detected in 3 patients(15%), 2 of them only presented with micrognathia.Otorhinolaryngologic abnormalities were found in 4 cases(20%), 3 of whom had laryngeal abnormalities, one of whom had cleft palate.Psychomotor developmental delay was found in 9 cases.

Conclusions
Congenital heart defects, hypocalcemia and/or impaired immune function are diagnostic features for 22q11.2 deletion syndrome, and they should be considered for cytogenetic analysis.

Key words:
22q11.2 deletion syndrome; Phenotype; Molecular cytogenetic; Congenital heart disease


Blood pressure variability is also known as blood pressure fluctuation.Normal blood pressure fluctuation presents a dipper type curve in one day.Compared with the daytime,night blood pressure level is lower by 10%-20%.The autonomic nervous system function disorder can appear in patients with type 2 diabetes,which leads to blood pressure rhythm abnormalities and increased blood pressure variability,increasing the morbidity and mortality of cardiovascular and cerebrovascular diseases,meanwhile accelerating the progression of other diabetic complications.It is an important measure for preventing and improving the prognosis of various complications to correct the abnormal blood pressure circadian rhythm of type 2 diabetic patients.


1. A filter cartridge comprising a housing surround the outer pipe placed in an internal cavity of the housing batch absorber sorbent tampon grid and dust at the bottom of the charge, a cover with holes for receipt of harmful substances from the air, characterized in that the cartridge comprises a tampon additional dust situated in the upper part of the charge, while the blend is a block-monolithic structure with internal porosity, in which the adsorbent particles are made irregular in shape and are connected to a binder resin together with the inner walls of the housing and the dust tampons tube is biased towards a narrow portion of the filter and located at an angle of 75 ° -87 ° to the plane of the bottom of the housing to reduce the dimensions of the filter portions protruding forward in order to improve viewing inside the mask and produce a full charge in the pipe remote from the filter zone, wherein the composition is used as a liner material and cover on the grid polypropylene block copolymer or polypropylene with a high modulus of elasticity with high frost resistance and chemical resistance. ! 2. A filter cartridge comprising a housing surround the outer pipe placed in an internal cavity of the housing batch absorber sorbent tampon grid and dust at the bottom of the charge, a cover with holes for receipt of harmful substances from the air, wherein the filter cartridge comprises an aerosol, made in the form of a plate spanned filter material installed in the upper part of the charge and fixed by clamping between the peripheral sides of the filter cover and


This paper investigates the dielectric and electromagnetic behavior of polyacrilonitrile composites thin films. Polyacrylonitrile/N-Methyl-Pyrrole composite thin films were prepared by polymerization of pyrrole on polyacrylonitrile matrix [1]. Different concentrations of n-methyl-pyrrole were added to the polyacrylonitrile/dimethylformamide solution to achieve polymerization of pyrrole. The amount of n-methyl pyrrole was varied in order to investigate the influence of the concentration on the dielectric and also on electromagnetic properties in special electromagnetic shielding of the composite polymer.


In a preface to a book on computational geometry J T Schwartz Sc wrote Till now computer science has been largely combinatorial and symbolic having the manipulation of patterns and tables of data as its principal content In robotics however computer science makes contact with real world geometric and physical phenomena such as compliance of elastic bodies the frictional phenomena that occur when two bodies come in contact errors in modeling which are inevitable in the real world the sudden changes of state which occur when two bodies collide unexpectedly and so forth It is to be expected that much interesting new computer science will emerge from contact with these rich conceptual domains and in particular that computer science will become more traditionally mathematical and continuous The theory of hybrid systems HS can be considered as an important step to ward the realization of this vision By a hybrid system I mean a system which is a product of the interaction between a discrete state transition system an automaton a program and a continuous di erential dynamical system In this informal talk I will try to explain what this theory is about and in what aspects it di ers from other computational theories In order to do so I will rst section point out explicitly the underlying assumptions of traditional computability theory concerning the phe nomena it is supposed to model In section I will show how these assumptions are not valid in what I call real life computations where the computer is embedded in the physical world In section I will show how reactive and real time systems can be considered as preliminary steps toward hybrid systems Finally by mentioning some trends and developments in computer science AI robotics and cognitive science I hope to put HS in a broader perspective and show you that the transition to HS might be even more signi cant than you think Since unlike other participants I did not have any astonishing new results on HS since the announcement of this workshop the talk will be completely non technical and the uninterested ones among the audience can nd comfort in other presentation in this workshop


In this paper, we propose a potential modified route-searching algorithm to find all feasible paths in a new place which is like an unknown maze. The maze-like place is assumed to be a region constructed by grids and each grid is supposed to have at most four directions for moving. A searching algorithm is developed to accomplish the required tasks for patrolling every path in the new place. Based on the traditional depth-first graph traversal method, we build up a local-maze coordinate system to record the visited pathway. The main results of this paper will give an experiment simulation to demonstrate the success of proposed design.


Event-brand congruence is crucial for the success of event marketing and sponsorship. However, a number of different approaches to measure the construct have been used. Additionally, there is no agreement on the main drivers of global congruence judgments. The present research addresses these issues. Results show that measuring global congruence with either single-item or multiple-item measures leads to different results and interpretations. Semantic differentials appear to be least suited in this respect. Regarding single-items measures, reasons pro and con their use are identified. Moreover, results show that image-based, functional-based, and user-based congruence should be considered jointly as important antecedents of global event-brand congruence.


A genetic algorithm is proposed in this article for discovery of association rules. The main characteristics of the algorithm are: (1) The individual is represented as a set of rules (2) The fitness function is a criteria combination to evaluate the rule's quality - high precision prediction, comprehensibility and interestingness -- (3) Subset Size-Oriented Common feature Crossover Operator (SSOCF) is used in the crossover stage (4) mutation is calculated through non-symmetric probability and selection strategy through tournament and (5) the algorithm was implemented using the library lambdaj. Finally, the genetic algorithm effectiveness and the quality of the rule in the experimental results are shown.


The Heat Cycle Research Program is currently investigating the potential improvements to power cycles utilizing moderate temperature geothermal resources to produce electrical power. Investigations have specifically examined Rankine cycle binary power systems. Binary Rankine cycles are more efficient than the flash steam cycles at moderate resource temperatures, achieving a higher net brine effectiveness. At resource conditions similar to those at the Heber binary plant, it has been shown that mixtures of saturated hydrocarbons (alkanes) or halogenated hydrocarbons operating with a supercritical Rankine cycle gave improved performance over Rankine cycles with the pure working fluids executing single boiling cycles. Recently, in addition to the supercritical Rankine Cycle, other types of cycles have been proposed for binary geothermal service. This paper explores the limits on efficiency of a feasible plant and discusses the methods used in these advanced concept plants to achieve the maximum possible efficiency. The advanced plants considered appear to be approaching the feasible limit of performance so that the designer must weigh all considerations to find the best plant for a given service.


AIM
This study is to investigate whether the set point of HbA1c being 5.2% or more is too strict a line to be drawn by Tokutei-kensin (Health Examination for metabolic syndrome in Japan) on people 65 years old or more from the view point of glucose metabolism.

METHODS
Samples were out-patients of the community clinic and community residents from the jurisdiction of the community clinic. (1) Epidemiological data on those who were in their 50s, 60s and 70s with HbA1c level between 5.2% or more. (2) Second study was done on those who aged 40 years or more with their initial HbA1c measured after 1995 with a result of 6.1% or less, and had been followed for more than 5 years since.

RESULTS
First study covered 54.3% and 69.3% of age groups of 60s and 70s respectively and the percentages of HbA1c between 5.2% and 6.1% were 40.9%, 36.8% respectively. HbA1c level of 40 people who met the criteria of second study were followed for 5 to 13 years. Among 29 cases of those who aged between 40 and 75, 15 cases showed an increase from 5.2% to 6.1% over an average of 9.6 years of follow up and 7 of them increased to higher than 6.5%. When limited to the age of 65 to 75, 8 of them increased from 5.2% to 6.1% and 2 of them increased to higher than 6.5%. None of the 19 cases who were more than 40 years old and had an initial HbA1c below 5.2% showed a significant elevation of HbA1c.

CONCLUSIONS
It is reported that diabetic cardiovascular complications exists in pre-dibetic stage and oral glucose tolerance test revealed high percentage of impaired glucose tolerance among HbA1c values between 5.2 and 6.1%. It has been investigated that among people aged between 65 and 74, those who had a HbA1c higher than 5.2% showed an increase of HbA1c over years when compared to those whose HbA1c below 5.2%. It was also reported that about 40% of the population of people in their 60s and 70s had a between HbA1c 5.2% and 6.1%. It is considered important that an assessment of state of arteriosclerosis and intervention of life style to people aged 65 to 74 when a value of HbA1c over 5.2% is found.


By low stringency screening of a λ‐Shizosaccharomyces pombe genomic library, we have cloned a GATA factor homologous gene, gaf2+, within a 3.1‐kb EcoRI fragment. The gaf2 ORF predicts a protein of Mr 61 kDa consisting of intronless 564 amino acids corresponding to 1,692 bp. Gaf2 has two zinc‐fingers as Urbs1 of Ustilago maydis, whereas most of fungal GATA factors have only one zinc‐finger. The separation between two zinc‐fingers of Gaf2 is rather long. In addition to gaf2, the sequence analysis revealed a Val‐tRNA gene in the 3′‐flanking region of gaf2. Northern blot analysis indicated that the gaf2 gene is transcribed constitutively irrespective of the nitrogen source in a medium.


More than seventy years since the Bolsheviks came to power, there is still no comprehensive study of workers' activism in history's first successful workers' revolution. Strikes and Revolution in Russia, 1917 is the first effort in any language to explore this issue in both quantitative and qualitative terms and to relate strikes to the broader processes of Russia's revolutionary transformation. Diane Koenker and William Rosenberg not only provide a new basis for understanding essential elements of Russia's social and political history in this critical period but also make a strong contribution to the literature on European labor movements. Using statistical techniques, but without letting methodology dominate their discussion, the authors examine such major problems as the mobilization of labor and management, factory relations, perceptions, the formation of social identities, and the relationship between labor protest and politics in 1917. They challenge common assumptions by showing that much strike activity in 1917 can be understood as routine, but they are also able to demonstrate how the character of strikes began to change and why.


The surface impedance of various high-temperature superconductors has been examined in the millimeter-wave spectral range. Experiments on YBa/sub 2/Cu/sub 3/O/sub 7/ ceramics and thin films and on (evidently fairly poor quality) Bi/sub 2/CaSr/sub 2/Cu/sub 2/O/sub 8/ single crystals give effective penetration lengths which exceed the London penetration depth and finite and significant surface impedance in the microwave and millimeter-wave spectral range. It is found that both R/sub S/ (surface resistance) and lambda /sub eff/ (effective wavelength) decrease with increasing sample quality, and the temperature dependence of lambda approaches the form expected for single pairing. These observations are in agreement with a model where the surface impedance is dominated by losses and effective magnetic field penetration caused by Josephson-type effects at grain boundaries. The surface resistance exceeds the Mattis-Bardeen limit in both ceramic and thin-film specimens.<<ETX>>


This paper presents SUSAN (Structure Preserving Noise Reduction algorithm) for gray scale images contaminated by traditional median noise. Remote sensing images are affected by different types of noise like Gaussian noise, Speckle noise and impulse noise. These noises are introduced into the under water images during acquisition or transmission process. In this paper traditional median filter and structured preserving noise reduction Algorithm is used for reduce the noise rate, when compare to this filter and SUSAN Algorithm, Structured Preserving Noise Reduction gives better results. Keywords—Traditional median filter, structure preserving noise reduction algorithm.


According to the development status of the polyurethane materials in tire industry,the preparation of polyurethane tire and its application materials are discussed.The performance advantages of the polyurethane tire are analyzed.The market prospect of the polyurethane tire is given out.Meanwhile the future development trends of the polyurethane tire are pointed out.


This paper describes our Kyoto-U system that attended the IWSLT06 Japanese-English machine translation task. Example-based machine translation is applied in this system to integrate our study on both structural NLP and machine translation.


Aim of the study is to assess how students in 6 th , 7 th and 8 th grades of primary education see the project works made in science education and their implementation processes. The study was fulfilled upon the descriptive survey model to collect data. Participants of the research were 100 students who had project implementation experiences in science education, and they were from 24 primary schools in 7 districts randomly chosen in the city of Istanbul in Turkey. Data of the study were collected by using a semi-constructed interview form offered to students during the 2005-2006 teaching year. In the research, following items were examined: The extent to which students are inspired from the previously made projects during their own project selection process, the level of scientific document survey and the effects of contemporary events, science and technology class topics and students' interest areas. It was seen that internet is the mostly used source to obtain information. For students, one of the most problematic issues faced during the project implementation is the time limits set out by teacher. It was found that the most obvious benefit obtained by students from the project works is their increasing interest towards science and technology class. The most significant change seen by students regarding project preparation is their increasing grades in exams during and following the project works.


In this paper, an approach for polyglot speech synthesis based on cross-lingual frame selection is proposed. This method requires only mono-lingual speech data of different speakers in different languages for building a polyglot synthesis system, thus reducing the burden of data collection. Essentially, a set of artificial utterances in the second language for a target speaker is constructed based on the proposed cross-lingual frame-selection process, and this data set is used to adapt a synthesis model in the second language to the speaker. In the cross-lingual frame-selection process, we propose to use auditory and articulatory features to improve the quality of the synthesized polyglot speech. For evaluation, a Mandarin-English polyglot system is implemented where the target speaker only speaks Mandarin. The results show that decent performance regarding voice identity and speech quality can be achieved with the proposed method.


A stepper rotor is driven with a narrow pulse width input which matches the load conditions on the motor. The subsequent position of the rotor is detected as being rotated or non-rotated by application of a detection pulse to the rotor. An additional driving pulse of increased width is applied should the rotor be found in a non-rotated state. A stabilizing pulse prevents intermediate rotor positioning. Position of the stepper motor is detected by passing a current through the rotor cell. The rate of increase in detection current is different when the rotor has rotated and when the rotor does not rotate because coil inductance and magnetic flux directions passing through the saturable portion of the stator are different depending upon the position of the rotor. The width of the driving pulse for normal operation is selected from a range of pulse widths so as to match the load on the motor.


Many methods for the detection of red cell antibodies of the IgG type need incubation times between 15 and 20min at 37 °C. Microwaves induce a rapid movement of molecules resulting in heat delivery into the solution. A group from China shortened the incubation time of ELISA procedures from 1 -1.5 h to 15-20 s. To the best of our knowledge no attempts to use microwave irradiation in immunohematology have been published. We now report preliminary results for the gel technique (ID system), blood group typing on microtiter plates (Erytype), the SolidScreen test and the cross-match in plastic vials. Both the ICT and enzyme-dependent methods could significantly be shortened to incubation times of 60-75 s without a relevant loss of specificity and sensitivity for most of the antibodies tested. The commercially available microwave instruments that we used proved to be not ideal for our purposes. The choice of instruments capable of measuring the temperature within a defined solution should improve the results further, allowing microwave techniques to become routine methods of the immunohematological laboratory.


Agricultural by-products originated from food processing factories represented one of the permanent environmental problems. New trends were raised to utilize these valuable wastes full of nutraceuticals and phytochemicals. Pomegranate (PPP) and orange peels (OPP) were used in the current study to assess their beneficial effects. The counts of microorganism were determined and found in the safe permitted level in food.Afterward peels were directed to prepare bakery products.Pomegranate peel contained iron, zinc, calcium, potassium, magnesium, phosphorus and sodium at levels of 12.75, 5.9, 202.7, 135.8, 45.46, 66.38 and 38.91 mg/100g dry matter, respectively. Orange peel valued 19.5, 6.7, 635.8, 785.9, 91.4, 57.55 and 32.34 mg/100g dry matter, respectively. Pomegranate peel contained vitamins B1 and D3 at levels of 0.014 g/Kg and 0.023 MIU/kg, respectively. While, in orange peel were 0.027 g/kg and 0.019 MIU/kg, respectively. Pomegranate peel had total, soluble and insoluble dietary fiber contents of 19.7%, 5.8% and 13.9%, respectively. Whereas, orange peel registered 33.9%, 6.5% and 27.4%, respectively. GC/MS analysis of orange peel showed the existence of Dihydrocarvone (30.25%) and 4',6-Dimethoxyisoflavone-7-O-β-Dglucopyranoside (20.83%). Phloroglucinol (28.52%), (S)-(-)-Citronellic acid (14.24%) werethe bioactive compounds. Sensory evaluation for overall acceptability showed that non-significant difference existed between T1 (Control); T2 (10%PPP) and T5 (10%OPP).The chemical composition of the resulting cake showed that by increasing the substitution levels of either PPP or OPP, the ash and dietary fiber content increased, the available carbohydrate and fat content decreased and the protein content was not affected compared to the control without addition. The decrease in caloric values ranged between 404.34-420.59 kcal/100 g compared to 453.66 kcal/100 g for the control sample. It was found that by increasing the replacement ratios, the texture properties were affected and the microbial content of the resulting cake samples decreased, which gives an indication of the possibility of increasing the preservation period. The results indicated that PPP and OPP by-products can serve as a good source of bioactive components. It could be recommended that incorporation of the mentioned raw material with wheat flour 72% extraction to obtain healthy bakery productshave high biological value.


The present invention relates to a photoacoustic imaging method for real-time acoustic lens and the multilayer reflective film detection based on a sound pressure distribution medium is coupled to the biological tissue using an acoustic lens since the photoacoustic effect generated directly imaged on the image plane, through a multilayer the acoustic reflection film pressure distribution on the image plane into a respective intensity distribution, and a CCD recording the light intensity distribution, to obtain a clear image of a tissue level in real time; the test sample can be obtained using the technique of time-resolved tomographic images at different levels. The device consists of a transparent flexible rubber layers, the optical fiber, the acoustic lens, the sound-transmitting opaque material, the multilayer reflective film, CCD, computer configuration. Wherein the transparent layer is a flexible rubber, fiber, the acoustic lens, sound-permeable opaque material, a multilayer reflecting film and a CCD mounted on opposing aluminum cylindrical cavity; an optical fiber connected to form a source through a connector to the laser; and the other laser mirrors illumination source; and a computer electrically connected to the CCD.


Aluminum shear panels can dissipate significant amount of energy through hysteresis provided strength deterioration due to buckling is avoided. A detailed experimental study of the inelastic behavior of the full-scale models of shear panels of 6063-O and 1100-O alloys of aluminum is conducted under slow cyclic loading of increasing displacement levels. The geometric parameters that determine buckling of the shear panels, such as web depth-to-thickness ratio, aspect ratio of panels, and number of panels, were varied among the specimens. Test results were used to predict the onset of buckling with proportionality factor f in Gerard's formulation of inelastic buckling. Moreover, a logarithmic relationship between buckling stress and slenderness ratio of the panel was observed to predict experimental data closely. These relations can be further used to determine the geometry of shear panels, which will limit the inelastic web buckling at design shear strains. DOI: 10.1115/1.2793135


The controller of digital random vibrancy replaced of the simulation random equalizer in random test control.Through quantizing,the simulation signal was changed into digital signal.At the same time,FFT was used to change vibration time-threshold into relative frequency-threshold signal.And the system carried out equilibrium modifying in frequency-threshold so that the PSD of control point met the design requirement.The spectral equilibrium,frequency resolving power,and other performances which realized by this technology were better than those realized by simulation random equalizer control.


known to interact directly with the heme iron of cyt. P450,4) although some derivatives bind to the lipophilic regions of the apoprotein and simultaneously bind to the prosthetic heme iron.5) The modeof action of some wellknown fungicides (imidazole derivatives are econazole, miconazole, imazalil, prochloraz, fenapanil, clotrimazole, etc.) resembles that already mentioned. Several classes of imidazole derivatives are very potent inhibitors of cyt. P450, and a number of these compounds are useful as zoocidal synergists.6) In insects, methylfarnesoate epoxidase (MFE, a cyt. P-450 isozyme catalysing the conversion of methylfarnesoate to JH) was sensitive to inhibition by imidazoles.7) Imidazole-containing anti-JH agents have been suggested as possible inhibitors of MFE.8) Furthermore, A-phenyl-B-imidazolyl metyrapone (PIM)9) was an in vitro inhibitor of cyt. P-450, and


In this paper, we propose the explicit construction of a new class of lattices based on polar codes, which are provably good for the additive white Gaussian noise (AWGN) channel. We follow the multilevel construction of Forney et al. (i.e., Construction D), where the code on each level is a capacity-achieving polar code for that level. The proposed polar lattices are efficiently decodable by using multistage decoding. Performance bounds are derived to measure the gap to the generalized capacity at given error probability. A design example is presented to demonstrate the performance of polar lattices.


The first silicon sensors with a three-dimensional architecture, in which the n and p electrodes penetrate through the entire substrate, have been successfully fabricated. The fabrication method, results covering electrical properties, tests with infrared microbeams, and detection of beta, x- and gamma rays are covered, as is their satisfactory operation after irradiation with up to 10E15 55 MeV protons/sq. cm. We also describe ongoing work with active edges, in which etched sensor edges form one electrode, and which should be sensitive to within a micron of the physical edges. Finally, plans for the next fabrication run, and possible future applications are covered. These include formation of mosaic detectors for the synchrotron x-rays used to determine the three-dimensional shape of protein molecules.


Large impacts on growing planets can be fundamentally different in outcome than small impacts because they can lead to a planet-enveloping cloud of siliate vapor with a radiative cooling time long compared to dynamic time scales. Under these circumstances, there can be preferrential volatile loss by hydrodynamic outflow immediately above the silicate cloud deck. This loss is in ddition to the prompt, nonpreferential loss immediately following the impact event. During this time, evaporative loss (Jeans loss) can be 0.00001 of the planetary mass, provided the impact has substantial angular momentum and a magma disk forms. The loss is preferentially fromt he extremities of the disk and can be easily s100 bar-equivalents of CO2 or H2O. This implies devolatilization of Moon-forming material in an impact origin and may have important implications for the CO2 reservoirs of Venus, Earth, and Mars.


In order to reduce nursing intensity and improve freedom of the elderly and the disabled,a multi-function nursing wheelchair which can switch chair to bed and realize many kinds of posture transformation is designed.This paper introduces the mechanical structure design (position adjustment mechanism and variable wheelbase mechanism) and control design of posture transformation unit of multifunctional nursing wheelchair.


A DNA library of Pasteurella multocida ssp. multocida strain CVI 47459 was constructed in the Lambda GEM-11 vector. Recombinant clones that encoded dermonecrotic toxin (DNT) were identified immunologically with antiserum raised against purified DNT. By comparing the DNA restriction maps of the immunoreactive recombinants, we located the DNT gene. Hybridization studies with 10 strains of P. multocida ssp. multocida suggested that strains that do not produce the DNT do not contain sequences homologous to the DNT gene.


Estrogen deficiency causes a marked bone loss by stimulating osteoclastic bone resorption. To explore the endogenous bone‐resorbing factors involved in estrogen deficiency, we examined the bone‐resorbing activity present in the supernatant fraction of mouse bone marrow collected from ovariectomized (OVX) mice. Adding bone marrow supernatants at 20–80% to organ cultures of mouse long bones dose‐dependently stimulated bone resorption. The endogenous bone‐resorbing activity present in bone marrow supernatants from OVX mice was much higher than that from sham‐operated mice 2–4 weeks after surgery, and it was significantly diminished by indomethacin in vitro. Anti‐IL‐1α antibody completely neutralized the bone‐resorbing activity present in bone marrow supernatants from OVX mice. Antibodies against IL‐1β, IL‐6, and IL‐6 receptors also neutralized it, but partially. The concentration of IL‐1α measured by ELISA was much higher in bone marrow supernatants than in sera, but it was not appreciably changed before or after OVX. The concentration of IL‐1β in bone marrow supernatants from OVX mice was less than the detection limit. OVX stimulated IL‐1 activity in bone marrow supernatants measured by means of the proliferation of thymocytes. However, the level of IL‐1α present in bone marrow supernatants from OVX mice was insufficient to stimulate bone resorption. Compared with the serum concentration, bone marrow supernatants contained a much higher level of IL‐6 as well, and it was further increased by OVX. However, IL‐6 alone present in bone marrow supernatants from OVX mice again did not stimulate bone resorption. The concurrent addition of IL‐1 (50 pg/ml), IL‐6 (0.2 ng/ml), sIL‐6 receptor (1 ng/ml), and PGE2 (7 ng/ml), which equaled the endogenous concentrations in bone marrow supernatants from OVX mice, co‐operatively induced bone resorption. These results suggest that the enhanced bone resorption that occurs during estrogen deficiency is due to multi‐factors rather than to a single factor.


This paper aims to advance empirical knowledge of stock-bonds comovements thanks to the specific context of the pre-1914 French market. This period allows the measurement of the conditional correlation without any inflation thanks to the Gold standard regime. A multivariate Dynamic Conditional Correlation GARCH (DCC GARCH) model is implemented on four recently developed market indices to assess the varying correlation between stock and bond returns. We do obtain fluctuating but always highly positive conditional stock-bond correlations over a period of 76 years. This high correlation is observed not only with government bonds, as is the case in the majority of studies on this subject, but also with corporate bonds. Several macroeconomic factors are also tested to estimate their impact on the conditional correlations.


THE TRADE FACILITATION (TF) benefits of Single Window (SW) systems have been well documented in academic literature. Moreover, a number of jurisdictions that have implemented these systems have registered an increase in revenue collection, a reduction in trade transaction costs and general improvement in cross-border efficiencies. Despite the fact that many Customs administrations have expressed their desire to introduce the modern SW concept, many developing countries have not taken any substantial steps to implement such systems. Granted, most developing countries are plagued by certain technological and legal challenges that have acted as a barrier to the operation of SWs; their slow progress, however, does not entirely revolve around these challenges.


Unmanned surface vehicles (USVs) are new marine intelligent platforms that can autonomously operate in various ocean environments with intelligent decision-making capability. As one of key technologies enabling such a capability, path planning algorithms underpin the navigation and motion control of USVs by providing optimized navigational trajectories. To accommodate complex maritime environments that include various static/moving obstacles, it is important to develop a computational efficient path planning algorithm for USVs so that real-time operation can be effectively carried out. This paper therefore proposes a new algorithm based on the fast sweeping method, named the locking sweeping method (LSM). Compared with other conventional path planning algorithms, the proposed LSM has an improved computational efficiency and can be well applied in dynamic environments that have multiple moving obstacles. When generating an optimal collision-free path, moving obstacles are modelled with ship domains that are calculated based upon ships' velocities. To evaluate the effectiveness of the algorithm, particularly the capacity in dealing with practical environments, three different sets of simulations were undertaken in environments built using electronic nautical charts (ENCs). Results show that the proposed algorithm can effectively cope with complex maritime traffic scenarios by generating smooth and safe trajectories.


Abstract Proline-catalyzed synthesis of 1,8-dioxo-decahydroacridines is achieved via one-pot, three-component condensation of aromatic aldehydes, cyclic diketone, and aryl amines in aqueous ethanol medium. This method offers the advantages of proceeding in neutral and mild conditions, giving high to excellent yields of acridines with easy workup procedure.


The planar augmentation problem is the problem of adding a minimum number of edges to a given planar graph such that the resulting graph is biconnected and still planar. This problem is NP-hard [15]. We present a new $approximation algorithm for the planar augmentation problem. The best approximation factor achieved so far is 2 [15]. Furthermore, we ran extensive computational experiments on 'real world' graphs. The outcome is surprising: The solution of our new algorithm is very often optimum and in almost all cases the solution found by our algorithm contains at most one more edge than in an optimum solution.


We have developed a new scattering chamber for ion-beam analysis of environmental materials with the 1.1-MV Pelletron accelerator at the Union College Ion-Beam Analysis Laboratory. The chamber was constructed from a ten-inch, Conflat, multi-port cross and includes a three-axis target manipulator and target ladder assembly, an eight-inch turbo pump, an Amptek X-ray detector, and multiple charged particle detectors. Recent projects performed by our undergraduate research team include proton induced X-ray emission (PIXE) and Rutherford backscattering (RBS) analyses of atmospheric aerosols collected with a nine-stage cascade impactor in Upstate New York. We will describe the construction of the chamber and discuss the results of some commissioning experiments.


This paper introduces the development and application of synthetic fiber reinforced concrete and the basic properties of several kinds of it. It discusses the technique characters of polypropylene fiber concrete. The future development of this synthetic fiber concrete is suggested, and the application of it in canal seepage control is prospected.


294 Background: Black men have the highest incidence of clear cell renal cell carcinoma (ccRCC) and have a worse prognosis than women or White patients in the curative setting. We previously reported that women with metastatic ccRCC have an inferior prognosis to men which is dynamic with age. The prognosis of Black patients with metastatic ccRCC is not well described. Methods: Clinicopathologic features and survival of patients diagnosed with clinical stage IV ccRCC between 2004-2016 were obtained from the National Cancer Database (NCDB). Patients were stratified according to their age at diagnosis, race, and sex. Uni- and multi-variable chi-square, logistic regression, and overall survival (OS) analyses were used for comparisons. Results: In this cohort, there were 900 Black men, 461 Black women, 13,422 White men, and 6363 White women. Black patients were less likely to have private insurance, lung metastases, or to live in high income zip codes and were more likely to have liver metastases. Compared to White race, Black race was associated with worse OS in the overall cohort (HR 1.17 [95% CI 1.10-1.24], p<0.001; multivariate HR 1.14 [95% CI 1.06-1.21], p<0.001) and in a smaller cohort limited to patients receiving systemic therapy as their initial treatment modality (n=10,869; HR 1.22 [95% CI 1.11-1.33], p<0.001). Within age groups, the highest disparity was observed among younger patients (<50yr: median OS 12.0 vs 22.1mo, p=0.004; 50-64yr: 14.6 vs 20.7mo, p=0.0001; >65yr 9.7 vs 14.5mo, p=0.002). When stratified by age and race, males had similar or superior survival compared to females in most subgroups, however Black males under 50yrs had markedly inferior OS compared with Black females (median OS 10.4mo vs 17.1mo for Black females, p=0.0083) and compared with White patients (Table). Conclusions: Young Black males with metastatic ccRCC demonstrate remarkably poor OS in this cohort; whereas males otherwise have a more favorable prognosis. Potential hypotheses to explain this disparity include differences in obesity and smoking incidence in this population as well as unmeasured factors impacting access to care.[Table: see text]


In this thesis we study certain irrational \(\mathcal{W}\)-algebras and their representations. Main example that we investigate is the simple Bershadsky-Polyakov vertex algebra \(\mathcal{W}_k(=\mathcal{W}_k(sl_3, f_\theta))\), i.e. the minimal affine \(\mathcal{W}\)-algebra associated to \(sl_3\). T. Arakawa proved in [9] that \(\mathcal{W}_k\) is rational if \(k\) is a half integer greater that \(-3/2\). We study cases where \(\mathcal{W}_k\) is irrational, and classify \(\mathcal{W}_k\)-modules for certain \(k\). Main tools that we use to classify irreducible modules are Zhu's theory and formulas for singular vectors. Zhu algebra is realized as a quotient of the Smith algebra from [44]. Classification of irreducible strong modules for \(\mathcal{W}_k\) (i.e. modules with finite dimensional weight subspaces for the the operator \(L(0)\)) is hence connected to the classification of finite dimensional representations of the Smith algebra. In the case \(k=-5/3\), we show that \(\mathcal{W}_k\) is realized as a vertex subalgebra of the Weyl vertex algebra. We prove that in this case \(\mathcal{W}_k\) has exactly 6 irreducible strong modules. In the case \(k=-9/4\) , \(\mathcal{W}_k\) is an important example of a logarithmic vertex algebra. We classify strong \(\mathcal{W}_k\)-modules for \(k=-9/4\) and prove that \(\mathcal{W}_k\) has exactly 3 irreducible strong modules. In order to show that \(\mathcal{W}_k\) is irrational, we construct an uncountable family of weight modules for \(\mathcal{W}_k\) outside of category \(\mathcal{O}\). We construct a family of singular vectors which generalizes Arakawa's formulas for singular vectors for \(k\) half integer from [9]. For \(k=-1\) and \(k=0\) we classify all modules in the category \(\mathcal{O}\). In the case \(k=0\), we give an explicit realization of the vertex algebra \(\mathcal{W}_k\) and its modules as certain irrational subalgebras of lattice VOAs. We also study the algebra \(\mathcal{W}_k\) when \(k\) is an integer greater than -1.