Heavy metals in soil, water and air is a great concern. Toxic heavy metals ultimately affect plant, Animals, and through food chain directly influence human life. In present study, the effect of heavy metals (Cu, Zn), Nfertilizers and EDTA on growth and biomass of cannibus sativa plant was evaluated. The Cu and Zn phytoextraction potential of Cannabis sativa plant under various treatments of N-fertilizers and EDTA were investigated. Metals (Cu, Zn) significantly reduced the plant growth and biomass while the fertilizer application increased the plant growth and biomass under metals stress. The application of EDTA alone increased the metals (Cu, Zn) accumulation in root, stem and leaves but reduced the plant height, root length and biomass. The maximum accumulation of Cu in root (75 µg/g DW), stem (55 µg/g DW) and in leaves (45 µg/g DW) was found with EDTA treatment (T3). Maximum Zn concentration in Leaves (155 µg/g DW) and root (148 µg/g DW) was observed in plants treated with EDTA. Conclusively, metals contaminated soil considerably reduced plant growth and biomass while metals in combination with N-Fertilizer the plant growth and biomass was enhanced. Addition of EDTA significantly enhanced phytoaccumulation of metals (Zn, Cu).


The Transformed Eulerian Mean formalism greatly simplifies the study of eddy mean flow interactions. However the standard formalism suffers of a number of limitations that make it not suitable for typical oceanic conditions. Here we show how to extend the formalism to represent properly boundary conditions and regions with steep isopycnal slopes. This formalism is then used to derive a parameterization for mesoscale motions in the ocean.


A sigmoidal forest yield model is estimated from longitudinal measurements of sample plots where measurement times and intervals vary. The projection form of the yield model is fitted as a generalized linear model (GLM) with composite link functions and an offset. This allows age and additional covariates to be easily incorporated in a more flexible nonlinear structure than that provided by single link GLMs. Also, existing algorithms for fitting generalized linear mixed models (GLMMs) are easily adapted to fit the projection model, thereby allowing incorporation of random plot effects. Estimation for the composite link GLMM is described, as well as an alternative to the GLMM in which random effects are incorporated as linear components on the same scale as the response. This model is referred to as an additive generalized linear mixed model (AGLMM). Unlike the GLMM, the fixed-effect parameter estimates in the AGLMM are population-average (PA). The AGLMM is fitted using a modification of a subject-specific (SS) algorithm using marginal expectation. The random effects in the AGLMM may have a natural interpretation or may provide a means of generating a marginal covariance structure, as is the case with linear mixed models. A simple example of an AGLMM for binomial data and logit link is given. In both this and the forest yield example, a single, artificial random effect is constructed to give exchangeable correlation for observations within-subjects and a comparison of fit of the AGLMM and GLMM is made using a conditional quasi-deviance. If the fit is similar and PA parameter estimates are required, the AGLMM is preferred.


The paper reconstructs the origins of the quantity theory of money and its applications. Referring to the history of money, it is shown that the theory was flexible enough to adapt to institutional change and could thus maintain its actuality. To this day, it is useful as an analytical framework, but due to Goodhart's Law, it nowadays has only limited potential to guide monetary policy. Finally, an empirical analysis drawing on data from Switzerland and the Euro zone confirms a stationary relationship between the quantity of money and GDP.


Scanning force microscopy is an ideal technique for non-destructive investigation of ferroelectric domains. Application of such domains for efficient optical frequency conversion and for ultrahigh-density data storage requires μ m to nm-sized domain structures. Thus the high lateral resolution offered by scanning force microscopy is highly desired. However, the mechanism causing the domain contrast is not yet fully understood. Investigations of periodically-poled lithium niobate samples with conductive as well as insulating surface layers indicate that the observed domain contrast is not solely due to the electromechanical piezoresponse.


Polymorphism. Two alleles of a DNA region (HFABPL) with high homology to the bovine heart-fatty acid binding protein (H-FABP) cDNA were detected through RFLP analysis of PCR products digested with the restriction enzyme RsaI. Primer Source. Primers were designed based on the bovine cDNA sequence for H-FABP (Billich et al., 1988) to amplify between nucleotides 66-676. The primer  s quences were as follows: 5' primer, 5'-TACCTGGAAGTTAGTGGACAGC-3' and 3' primer:


The regulatory gene levR of the levanase operon ofBacillus subilis was cloned and sequenced. It encodes a polypeptide of Mr 106,064 with two domains homologous to members oftwo families of bacterial activators. One domain in LevR is homologous with one region of bacterial regulators including SacT and SacY of B. subtifis and BgIG from Escherichia coli. Another domain ofLevR is homologous to one part of the central domain ofNifA and NtrC, which control nitrogen assimilation in Gram-negative bacteria. The levanase promoter contains two regions almost identical to the -12, -24 consensus regions present in 54-dependent promoters. The expression of the levanase operon in E. coli was strongly dependent on of4. Taken together, these results suggest that the operon is expressed from a -12, -24 promoter regulated by a 54-like-dependent system in B. subtilis. In Bacillus subtilis, the expression of the levanase operon is inducible by fructose and is subject to catabolite repression (1, 2). A fructose-inducible promoter has been characterized 2.7 kilobases (kb) upstream from the sacC gene, which encodes levanase. sacC is the distal gene of an operon containing five genes: levD, levE, levF, levG, and sacC (3). The first four gene products are involved in a fructosephosphotransferase system (fructose-PIS) in B. subtilis and share homology with the mannose-PTS of Escherichia coli (3). sacL mutants that constitutively express the levanase operon have been isolated (1). Three of the corresponding mutations have been located by DNA sequencing within the two most upstream genes of the levanase operon. The analysis of these constitutive mutations led to the conclusion that levD and levE gene products are involved in a fructoseN'S and are also negative regulators of the expression of the levanase operon. A specific component of the PNS is involved in induction of the bgl operon, which allows the utilization of B-glucosides in E. coli (4, 5). By analogy with the bgl system, the following model of regulation was proposed: in the presence of fructose LevD, LevE, LevF, and LevG polypeptides with the general proteins ofthe PNS make up a phosphotransferase cascade, leading to the transport and phosphorylation of fructose. In the absence of fructose, the phosphate group is transferred probably via the levD and levE gene products to the product of a regulatory gene not yet identified, thereby abolishing its activity (3). In this work, we have cloned the upstream region of the levanase operon and identified a positive regulatory gene called levR, which controls the expression of the operon.t The deduced LevR polypeptide has a molecular mass of 106 kDa. It contains two domains. Domain A shares similarity with the central domain of NifA and NtrC, two activator proteins controlling assimilation and fixation of nitrogen in several Gram-negative bacteria including Klebsiella pneumoniae and Rhizobium meliloti (6, 7). Domain B is similar to SacT and SacY, two regulatory proteins of the sucrose regulon in B. subtilis (8, 9), and to BglG, the regulatory protein of the bgl system in E. coli (10, 11). The levanase promoter contains two regions almost identical to the -12, -24 consensus regions present in o-54-dependent promoters (12). Moreover, it is shown that, in E. coli, expression of the levanase operon requires the presence of both levR and ntrA gene products. MATERIALS AND METHODS Bacterial Strains. E. coli TG1 (13) was used as a host for pHV143ld derivatives (14, 15), for pHT3101 derivatives (16), for pAC2 derivatives (see below), and for the sequencing vectors mpl8 and mpl9 (17). pHV1431d contains the pAMP1 origin of replication (14). pHT3101 contains an origin of replication from a Bacillus thuringiensis resident plasmid (16). pAC2 contains the pBR322 origin of replication (18). E. coli ET8000 ntrA' and ET8045 ntrA::TnJO (19) were used to test the expression of the levanase operon. B. subtilis 168 trpC2 and QB169 trpC2 sacL8 (1) were used as recipient strains during the construction of pRL2 and pRL3 plasmids. sacL, and sacLS alleles of levR on multiple copy plasmids were introduced into, and maintained in, B. subtilis lA510 recE4 leuA8 argi5 thrAS stp (20). Strain QB5500 was constructed as follows. QB5030 trpC2 sacC-lacZ erm (3) was transformed with linearized pJC30 plasmid. The kanamycin cassette was introduced into the chromosome by homologous recombination. One kanamycin-resistant (kanR) chloramphenicol-sensitive (cm') transformant was purified and characterized as QB5500 levR::aphA3 trpC2 sacC-lacZ erm. QB5038 levD::aphA3 trpC2 was constructed in the same way except that linearized pJC23 was used to transform B. subtilis 168. One kanR cm' transformant (QB5038) was isolated. Plasmids. The plasmids used in this work are described in Fig. 1. pJC30 was constructed as follows. A 1.5-kb Cla I restriction fragment containing the aphA3 gene (21) encoding kanamycin resistance was purified from plasmid pKa (8). This DNA fragment was cloned into the single Cla I site of pJC6 (2, 3). pJC23 was constructed by inserting the 1.5-kb aphA3 DNA fragment into the EcoRV site of pJC6. During this construction, the Cla I restriction sites were made blunt by using the Klenow fragment of DNA polymerase I. To construct a B. subtilis gene bank, Pst I-linearized pHV1431d plasmid DNA and Pst I-digested chromosomal DNA of Abbreviations: PTS, phosphotransferase system; UAS, upstream activating sequence; ORF, open reading frame. tThe sequence reported in this paper has been deposited in the GenBank data base (accession no. M60105). 2212 The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact. Proc. Natl. Acad. Sci. USA 88 (1991) 2213 pf IovR levD/levE levF .levG PLASMIDS


This thesis presents two essays studying the role of banks in financial markets and one which studies statistical inference in matching markets. The first chapter presents a new theory of the role of banks, providing an explanation for the role of publicly available securities on bank balance sheets. The model provides a unified framework for studying asset prices, portfolio choices, capital structure, and macroeconomic policies such as quantitative easing. Relative to existing models of banking, the paper emphasizes the demand for deposits rather than the expertise of bankers in making loans. The second chapter expands on the research agenda presented in the first by studying why traders might demand bank deposits. It formalizes the idea that deposits function as a form of money, because they are safe assets that avoid adverse selection problems in trade. The model presents a fundamental tension between banks creating large quantities of money-like assets and being vulnerable to financial panics. The third chapter studies identification and estimation in two sided matching markets where the desirability of matching with an agent can be summarized by a latent index. The paper first studies identification, showing that a many-to-one matching market allows for the estimation of parameters that cannot be estimated in a one-to-one matching market. It then studies the limiting distribution of a class of estimators and develops novel methods for proving such limit theorems.


Useful life of winding insulation is about 30 years. This may be reduced when it is overloaded or when it works in aggressive environments. When retrofitting is undertaken an increase to a higher insulation class is recommendable. So the generator's capacity should be increased, and this will not just more than fully compensate for the investment made it will also result in a more efficient use of the raw materials used and thus contribute to sustainable development. Our Brazilian experience shows that retrofitting with repowering is successful. The objective of this study is to present two cases of repowering, in which the old insulating materials were replaced by other, modern ones. So, eight SG of a Power Plant in Cubatão, S.P and two SG of CEMIG, MG had its power increased up to 40%. The discussion also deals with how to determine the new power obtained after the repowering, before the final load tests. In large machines, the load tests are critical. In order to calculate the field current of the full load SG to determine the temperature rise in field, indirect tests are undertaken. Which are the methods that present reliable results? This study compares three study methods, ASA, IEEE 115, and the General Method with their theoretical analyses. The ASA method is now regarded as normal in many countries. According to Brazilian Standards it is given under NBR-5052. In the IEEE 115, this method is named "Phasor Diagram Analysis—Salient-Pole Machines". The General Method is an academic treatment with a better theoretical basis.


The development of new high-power biofuel cells has been limited in the past by slow or indirect charge transfer. In this study, enzymatic biofuel cell (EBFC) systems were explored with different materials used to evaluate their applicability as redox mediators. Redox mediators of different natures have been selected for this research. Cytochrome c, Chlorophyll a, and supernatant of ultrasonically disrupted algae Chlorella vulgaris cells were examined as potential redox mediators. The effect of heparin on the EBFC was also evaluated under the same analytical conditions. The measurements of open circuit potential (OCP) and the evaluation of the current response in two modes of measurement were performed (i) during potential cycling in cyclic voltammetry measurements or (ii) at the constant potential value in chronoamperometry, and were applied for the evaluation of EBFC. Cytochrome c, Chlorophyll a, and the supernatant of ultrasonically disrupted algae Chlorella vulgaris cells-based redox mediators were efficient in the glucose oxidase (GOx) based EBFC. Electron transfer from GOx to the electrode was facilitated through the redox mediators adsorbed on the electrode. Electrodes modified with Chlorophyll a- and Cytochrome c-based redox mediators were suitable for the development of glucose biosensors. This was demonstrated by increasing the glucose concentration within 0 mM–100 mM in the system, the current density increased, and the system reached equilibrium rather faster regarding the electrochemical reaction. The power density is an important feature in revealing the action of biofuel cells. The highest power values were generated by the systems based on the application of redox-mediated Chlorophyll a and the supernatant of ultrasonically disrupted Chlorella vulgaris cells. The surface power density was about 2.5–4.0 µW/cm2. Control of a study was performed with a polished graphite electrode and the maximum surface power density was 0.02471 µW/cm2.


The high-pressure Raman spectra of the v1 and 2v2 Fermi doublet of CO2 and the C-H stretching, C-H bending and C-C-C breathing modes of naphthalene have been studied at pressures varying up to 2000 bar and temperatures between 60 and 90°C. The naphthalene bands show a blue frequency shift with increasing density, whereas a red shift for the Fermi resonance free stretching mode of CO2 is observed with increasing density. The blue shift is explained in terms of repulsive interactions probed by the naphthalene vibrations, while the red shift is related to the attractive forces dominating in the intermolecular potential as seen by the CO2 stretching mode. The experimental results support the validity of the site-to-site model of intermolecular potential. The intermolecular potential between naphthalene and CO2 is assumed to be anisotropic, and the proposed electrostatic quadrupole-quadrupole model of these interactions effectively explains the anisotropy in the intermolecular potential, the energy of association, and the frequency shifts.


By contrasting Walter Benjamin's fragmentary theory of quotation to the different ways his work has itself undergone quotation thus far, a new insight can be gained into the perception of the materiality and visuality of texts. The so-called Passagen-Werk , the project on the Parisian Arcades which Benjamin pursued for more than ten years until the end of his life, is the overflowing, yet voided space where this crossing takes place.


This article summarized Mg and the Mg alloy corrosion principle,as well as in the alloy various elements in magne-sium alloy function,and introduced the Mg alloy several typical protections methods:Enhances the alloy purity;Development new form alloy;Uses the advanced processing craft and so on.


The 125 MHz 13 C nuclear magnetic resonance (NMR) spectra of the hydrogenated derivatives of ring-opened metathesis polymers (ROMP) of bicydo[2.2.1]hept-2-ene (norbornene) and bicydo[2.2.1]hepta-2,5-diene (norbornadiene) prepared using a range of initiators, have been analysed in detail. The signals due to the methylene carbon atoms in the enchained cyclopentyl rings of these polymers show fine structure which is assigned to m and r ring dyads and mm, mr/rm and rr ring triads, enabling the tacticity of the hydrogenated polymer, and thus of the polyolefin precursor, to be determined for high-cis or high-trans polymers. Novel methods for making high-cis polymers are described and solvent-dependent variations in the stereospecificity of the propagation reaction have been observed.


In this article, a novel second-order cone programming based branch flow model is proposed for optimal power flow (OPF) in radial distribution networks. The main advantage of the proposed architecture is that it can recover the bus voltage angle difference and, thus, control the reactive power flow (PF), leading to a better voltage regulation in the network. Based on the line PF and the line impedance, a convex equation is derived and included with the model to retrieve the bus voltage angle difference. Finally, using the retrieved bus voltage angle difference within the global optimal solution space, an algorithm is developed to control the reactive flow for voltage regulation. The proposed model has been tested on modified IEEE 32 bus (IEEE 33 bus network) and IEEE 123 bus power network systems for different test cases. The simulation results are verified with the OpenDSS PF and the MatPower nonlinear programming (NLP) based OPF solutions. The computational efficiency of the proposed model is superior to the NLP models. Also, the proposed reactive flow control algorithm improves the voltage regulation of a network and promises a globally optimal solution.


Five different cadmium fixation methods of kidney were investigated in view of the leakage of the metal into fixative solutions and into the other materials for electronmicroscopic preparation. On the other hand, they were examined whether the fine structure was preserved well or not for light-and electronmicroscopic radio-autography. The better method was choiced, to add tannic acid to a fixative contain-ing paraformaldehyde and glutaraldehyde buffered with phosphate.


The young teachers are important part of the university's faculty.The growth and improvement of their teaching abilities play an important role in the total teaching quality of the university,and the promotion of its continual development.The cultivation of the young teachers' teaching abilities is the ability for practice.This paper analyses the influence and effect of the cultivation of young teachers' teaching abilities,exerted by practical factors(social practice and teaching practice).We develop a method for cultivation of the young teachers' teaching abilities,that is social practice as the carrier and teaching practice as the main body.


Economists are accustomed to conceptualising the macroeconomy as a system (mechanical, electrical or silicon-based) which is affected by impulses, shocks or internal momentum. The science and art of policy-making involves the detailed consideration of the channels by which these impulses impact on the economy. Policy-makers must then form a judgement about the type and strength of policy impulses that need to be injected so as to neutralise or offset the original shock.


The invention discloses a left-right column A reinforcing plate clamp for an automobile. The clamp comprises a platform, a clamping mechanism is arranged at each of four corners of the platform, each clamping mechanism comprises a support, each support is fixedly provided with a lower clamping plate, an upper clamping plate is hinged to each lower clamping plate, a power device is arranged on each lower clamping plate, the upper end of each power device is connected with the upper clamping plate, each power device is connected with the corresponding upper clamping plate through a hinge lever mechanism, a positioning pin is arranged on each lower clamping plate, the power devices are in pressure transmission, hydraulic transmission, power transmission, electromagnetic transmission and vacuum transmission, and the two clamping mechanisms at the left end of the platform and the two clamping mechanisms at the right end of the platform are symmetrically arranged. The left-right column A reinforcing plate clamp for the automobile is simple in structure and convenient to manufacture, saves labor, can simultaneously machine a left column A and a right column A, thereby improving production efficiency.


Different classes of dyes are widely used in textile industries, laser technology, medicine, printing, etc. Recently, the study of effects of various plasma–solution systems on organic dyes has become in the focus of attention. Methylene blue (MB) is used, most often, as a model solution. For instance, Sergeeva et al. (2002) compared the effect of the glow and diaphragm discharge on the MB water solution. It was found that diaphragm discharge was more efficient. The authors assumed that the destruction of the dye continued up to aromatic components. Maksimov et al. (2009) suggested that the differences in the destruction efficiency under the impact of the glow and diaphragm discharges were caused by the presence of sound and shock waves in the latter case. Under the impact of the corona discharge, the MB discoloration occurred within 20 min (Grabowski et al., 2007).


Since the development of surface magnetic features should reflect the evolution of the solar magnetic field in the deep interior of the Sun, it is crucial to study properties of sunspots and sunspot groups to understand the physical processes working below the solar surface. Here, using the data set of sunspot groups observed at the ButterStar observatory for 3,364 days from 2002 October 16 to 2011 December 31, we investigate temporal change of sunspot groups depending on their Zurich classification type. Our main findings are as follows: (1) There are more sunspot groups in the southern hemisphere in solar cycle 23, while more sunspot groups appear in the northern hemisphere in solar cycle 24. We also note that in the declining phase of solar cycle 23 the decreasing tendency is apparently steeper in the solar northern hemisphere than in the solar southern hemisphere. (2) Some of sunspot group types make a secondary peak in the distribution between the solar maximum and the solar minimum. More importantly, in this particular data set, sunspot groups which have appeared in the solar southern hemisphere make a secondary peak 1 year after a secondary peak occurs in the solar northern hemisphere. (3) The temporal variations of small and large sunspot group numbers are disparate. That is, the number of large sunspot group declines earlier and faster and that the number of small sunspot group begins to rise earlier and faster. (4) The total number of observed sunspot is found to behave more likewise as the small sunspot group does. Hence, according to our findings, behaviors and evolution of small magnetic flux tubes and large magnetic flux tubes seem to be different over solar cycles. Finally, we conclude by briefly pointing out its implication on the space weather forecast.


Cilex-Apollon is a high intensity laser facility delivering at least 5 PW pulses on targets at one shot per minute, to study physics such as laser plasma electron or ion accelerator and laser plasma X-Ray sources. Under construction, Apollon is a four beam laser installation with two target areas. To control the laser beam characteristics and alignment, more than 75 CCD cameras and 100 motors are dispatched in the facility and controlled through a Tango bus. The image acquisition and display are made at 10 Hz. Different operations are made on line, at the same rate on acquired images like binarizing, centroid calculation, size and energy of laser beam. Other operations are made off line, on stored images. The beam alignment can be operated manually or automatically. The article presents the architecture, functionality, performances and feedback from a first deployment on a demonstrator.


construction of fortress Europe . . . [could be transformed] into a concrete new ethnic Europe': cf, 'National Identities and Citizenship in the European Union' (1995) 1 European Public Law 633, at 659. 47 J. Ortega y Gasset, Revista de Occidente, 7th ed., (Alianza Editorial, 1996), at 41. 48 For the 'bleak record' of the Community institutions in dealing with would-be migrants and refugees even after the establishment of the 'Third Pillar' in the Maastricht Treaty, cf, Newman, op cit n 9, at 163


The standard of care for glioblastoma multiform (GBM), an aggressive form of cancer, has not significantly increased the prognosis for patients. ELTD1 (epidermal growth factor, latrophilin, and 7 transmembrane domain containing protein 1), a biomarker for angiogenesis, was found to be highly expressed in human high-grade gliomas. Novel treatments targeting ELTD1 with polyclonal (pAb) and monoclonal (mAb) antibodies were effective as a potential cancer therapy in a G55-xenograft mouse model. While our studies have demonstrated that the blood brain barrier (BBB) was leaky around the tumor region, other studies have shown that the BBB is not equally disrupted in GBM patients, therefore suggesting that the mAb may have difficulty crossing the BBB and infiltrating the tumor due to its size. To overcome these limitations, this study focused on the optimization of targeting ELTD1 by using an optimized svFc antibody fragment derived from our mAb against ELTD1. Immunocompromised mice were intracerebrally injected with human-G55 cells. Morphological MRI was used to monitor and calculate tumor volumes. Treatments using IgG, anti-ELDT1 mAb or fragment upon tumor detection. Vascular perfusion images were obtained to examine vascular alterations. Molecular targeting imaging (mtMRI) was conducted to assess the binding specificity of our antibodies against the tumor region. Targeting ELTD1 with varying antibodies (anti-ELTD1 mAb and scFv fragment) resulted in increased survival and decreased tumor volumes in a G55 xenograft GBM mouse model. Additionally, through the use of mtMRI, we determined altered levels of binding specificity against the tumor region using three different anti-ELTD1 attached probes (monoclonal and scFv fragment antibodies). Our data suggest that the optimization of an anti-ELTD1 therapy could be used to better target angiogenesis in glioblastomas.


: Currently, the content entertainment industry is dominated by mobile devices. As the trends slowly shift towards Augmented/Virtual Reality applications the computational demands on these devices are increasing exponentially and we are already reaching the limits of hardware optimizations. This paper proposes a software solution to this problem. By leveraging the capabilities of cloud computing we can offload the work from mobile devices to dedicated rendering servers that are way more powerful. But this introduces the problem of latency. This paper introduces a protocol that can achieve high-performance low latency Augmented/Virtual Reality experience. There are two parts to the protocol, 1) In-flight compression The main cause of latency in the system is the time required to transmit the camera frame from client to server. The round trip time is directly proportional to the amount of data transmitted. This can therefore be reduced by compressing the frames before sending. Using some standard compression algorithms like JPEG can result in minor size reduction only. Since the images to be compressed are consecutive camera frames there won't be a lot of changes between two consecutive images. So inter-frame compression is preferred. Inter-frame compression can be implemented efficiently using WebGL but the implementation of WebGL limits the precision of floating point numbers to 16bit in most devices. This can introduce noise to the image due to rounding errors, which will add up eventually. This can be solved using an improved interframe compression algorithm. The algorithm detects changes between frames and reuses unchanged pixels from the previous frame. This eliminates the need for floating point subtraction thereby cutting down on noise. The change detection is also improved drastically by taking the weighted average difference of pixels instead of the absolute difference. The kernel weights for this comparison can be fine-tuned to match the type of image to be compressed. 2) Dynamic Load distribution Conventional cloud computing architectures work by offloading as much work as possible to the servers, but this approach can cause a hit on bandwidth and server costs. The most optimal solution is obtained when the device utilizes 100% of its resources and the rest is done by the server. The protocol balances the load between the server and the client by doing a fraction of the computing on the device depending on the power of the device and network conditions. The protocol will be responsible for dynamically partitioning the tasks. Special flags will be used to communicate the workload fraction between the client and the server and will be updated in a constant interval of time ( or frames ). The whole of the protocol is designed so that it can be client agnostic. Flags are available to the client for resetting the frame, indicating latency, switching mode, etc. The server can react to client-side changes on the fly and adapt accordingly by switching to different pipelines. The server is designed to effectively spread the load and thereby scale horizontally. This is achieved by isolating client connections into different processes.


We present Deep Lithography with Protons (DLP) as a promising, fast prototyping technology to fabricate a waveguide-based micro-optical component with monolithically integrated 45° micro-mirrors acting as out-of-plane couplers, splitting the optical signal in 3 separated paths. For the first time, two different proton beam sizes are used during one irradiation and a 20µm collimating aperture is chosen to accurately define the out-of-plane coupling structures. We measured the surface roughness (Rq=27.5nm) and the flatness (Rt=3.17µm) of the realized components and experimentally measured the optical transmission efficiency of the micro-optical splitter component. The results are in excellent agreement with non-sequential ray-tracing simulations performed for the design.


Recent climate change and variability together with other anthropogenic drivers have exerted tremendous pressure on the fragile dryland ecosystem of Sokoto, North-western Nigeria. Vegetation phenology is one of the active indicators of the impacts of climate change on the ecosystem. This study aimed to monitor how the ecosystem of the area responds to the challenges associated with climate change in order to provide baseline information for policies and programmes geared towards addressing these challenges. It explored the applications of remote sensing data (MODIS-NDVI), GIS and statistical analyses in achieving this aim. Image processing operations such as data extraction, raster calculations, geometric transformations and creation of the region of interest were conducted using ArcGIS 10.5 model builder while TIMESAT software was used determined the vegetation phenological events such as the start, end and length of the growing seasons. The results indicated a persistent decline in the length of the growing seasons of the major vegetation classes in the area due to late onset and early cessation of the growing season which is positively correlated with rainfall distribution. From the year 2001 to 2016, 36% and 33% declined in the length of the growing season were recorded for shrubs and grasses respectively. These are positively correlated with the annual rainfall distributions in the area, with the correlation coefficient of r = 0.40 and r = 0.36 for the shrubs and grasses respectively. Implications of these on the ecosystem and livelihoods of the people in the area were discussed and ways forward suggested.


Patients with diabetes are often encountered for anaesthesia and surgery. Diabetic ketoacidosis is a common condition which is caused by production of ketones because of deficient insulin. Its prevalence can be as high as 30% in diabetic patients. Elective surgery is to be postponed in patients of DKA. Mortality is increased in patients of ketoacidosis undergoing surgery and hyperglycemia associated with diabetes is associated with increased hospital stay and increased incidence of wound infection. In this case, we present anaesthetic methods used for a patient in DKA undergoing exploratory laparotomy for peritonitis secondary to bowel perforation.


Glioblastoma multiforme (GBM) is the most lethal primary brain tumor and calls for novel therapeutic development. The neddylation pathway may be a therapeutic target, as global over activation of neddylation has been found in GBM patients and has correlated with shorter patient survival. Analogous to ubiquitination in reaction scheme and enzyme classes used, neddylation is a post-translational modification that is essential to many protein regulation and biological processes. Although non-cullin NEDD8 substrates have been investigated in recent years, the most well-characterized substrates of neddylation are the cullin subunits of Cullin-RING ligases (CRLs), which act as a scaffold for substrates to be ubiquitinated and degraded. The neddylation inhibitor MLN4924 targets NEDD8 Activating Enzyme (NAE), an upstream activator of neddylation, and induces cell cycle arrest, apoptosis and senescence in cancer cells. In this work, we investigated the context of vulnerability to Pevonedistat (MLN4924) in GBM. Efficacy of MLN4924 in glioma cell models was evaluated by measuring cell viability (CellTiterGlo®), colony formation efficiency, and cell cycle progression (flow cytometry with propidium iodide staining). GB1 (IC50= 0.28 μM), LN18 (IC50 = 0.19 μM), and GBM43 (IC50= 0.45 μM) were established as sensitive and M059K (IC50 = 5.5 μM), SNU1105 (IC50 = 20.9 μM), and GBM39 (IC50= 10.3 μM) as non-sensitive cell lines based on IC50 values. To discover genomic and/or proteomic markers of differential response, we collected RNA and protein from sensitive and non-sensitive cell lines after 0, 2, 8 and 24 hour treatment with MLN4924 for RNA sequencing and mass spectroscopy analyses. Multi-OMICS data point towards the absence of functional PTEN as a driver of MLN4924 resistance. Uncovering the mechanism underlying GBM's vulnerability to MLN4924 will expand the knowledge of neddylation's role in cancer and may arm physicians with an understanding of whether a GBM patient would respond to MLN4924 treatment or not.


This article tries to revisit those theories which supported some of our restorations, done some years ago.

During this period, many things have changed, people of all cultures have more facilities of communication. Many theories about restoration have being extended, in similar conditions. But it isn´t possible to generalize, with quite different surroundings. Each monument has it reason to be in its culture and society, which reflects its history and evolution.

Looking for the most important values to conserve or reintegrate, to transmit, may be the guide of the restoration in the future.

Having the solution for the lecture of the phases of the monument, and for the consolidation of the fabrics without losing its documental values, the next point to consider may be the environment.

After "filologism" and "critical restoration" (R.Pane), another way may continue.


Structural defects formed on {111} planes of BaTiO3 during the degradation of high performance multilayer Ni–BaTiO3 X7R ceramic capacitors are studied using transmission electron microscopy and electron energy loss spectroscopy (EELS). Regular pseudocubic barium titanate grains are present in as-produced (virginal) base-metal electrode capacitors. However, there is a coexistence of regular, modulated, and long-range ordered structures in intentionally electrically degraded devices. The EELS analysis demonstrates that the concentration of oxygen vacancies in barium titanate with modulated or ordered structures is higher than that in the regular perovskite grains. The clustering or accumulation of oxygen vacancies in the structural framework of BaTiO3 gives rise to the formation of new metastable structures. These observations are consistent with earlier models for degradation, but demonstrate that the details of the process may be more complex than originally assumed. Here we introduce new details on the n...


This study proposes the Artificial Neural Network with a Genetic Algorithm analysis approach to investigate the Overall Equipment Effectiveness of the deep-water disposal pump system. The ANN-GA model was developed based on six big losses over eighteen successive months of the operating period to evaluate the current and future performance of the DWD system. 70% of the data was used for training and 15% for each data validation and testing. The DWD system faces frequent failure issues, significantly impacting its performance, so it is important to reveal the main causes of these failures to manage them properly. ANN-GA is applied to make a linear trend prediction and assesses the confidence and accuracy of the results obtained. Analysis of ANOVA (variance) was adopted as an additional decision tool for detecting the variation of process parameters. ANN-GA results showed that the current OEE value ranges between 29% to 54%, whereas the predicted future system performance average is approximately 49%, which reflects the poor performance of the DWD pump system in the future compared to the world- class target (85%). ANN-GA analysis results indicated were very close and matched with the actual values. The model framework and analysis presented are used to develop a decision support tool for managers for early intervention to minimize system deterioration, reduce maintenance costs and increase productivity. Furthermore, it allows early identifying the potential area ofimprovement to support continuous improvement (CI) objectives by identifying and eliminating unnecessary maintenance activities. The proposed model framework uses the ANN approach to identify the current state and predict the future of the system performance to ensure confidence in the results. The contribution of the paper will be helpful for experts like managers, reliability engineers, and maintenance engineers to identify the state of the system's performance in advance.


THE three accounts of the battle of Megiddo which have come down to us' combine to give a vivid picture of the first major clash between the forces of the Egyptians and the Asiatics which marked the beginning of the expansionist policy of Tuthmosis III and his attempt to break the power of Mitanni in the north.2 Yet in all these descriptions no mention is made by name of the undoubtedly powerful king of Kadesh3 who headed the coalition of princes and chieftains who were ranged against the pharaoh. Thus, while the Egyptian documents contain many colorful details of the action, he himself remains anonymous, being designated by the accepted denigatory phrase of "wretched enemy." Nevertheless it is clear that he could claim the support of many lesser dynasts whose territories and cities were situated northwards from Megiddo over a wide area,4 and it may be inferred that he was, in fact, acting as the southern arm of Mitanni. All the more so is it to be regretted that there is no record of who he was, so that posterity has had to be co tent with knowing him solely by repute. But if the Egyptian sources disdain to refer to him by name, the possibility of confirmatory evidence from other documents cannot be ruled out, and a clue to his identity may come from some unexpected quarter. And, indeed, incidental mention of a king of Kadesh is contained in a document of somewhat later date which, however, refers back to an earlier period. Since this can help to throw light on "that wretched enemy of Kadesh," who, together with his ally, the prince of Megiddo, was hauled up over the ramparts into the latter's city after the first clash with the Egyptians,5 it is worth a reexamination. This reference occurs in one


During the period of social transformation,the diversity and complexity of disputes in China's rural areas,and the peasants' various demands for government assistance have provided a good time for the grassroots authorities to go deep into the rural areas and resolve disputes.For the grassroots authorities,their coordinating and warning function is far from satisfactory because there are till power abuses and malfunctions of authority.In order to better resolve rural disputes and construct a harmonious society,it is highly necessary for us to improve the operating mechanism,make clear the governments' responsibilities and further enhance external supervision.


Today's complex problems in international economics, business, urban planning, and many other fields require contextual understanding and action. The purpose of this chapter is to illustrate the interrelations among seemingly separate aspects of our life such as science, politics, aesthetics, business management, and economics with concrete and complex examples including multicultural management frictions in international business, governmental projects, and nongovernmental programs; political and economic restructuring currently taking place in East European countries; international debt repayment default prob lems in Latin America; and, more important, the problems in our own intellectual reorientation and reorganization in coping with them. These problems are ultimately epistemological rather than material and quantitative. The ability of an individual to effectively deal with multicultural human management frictions, frustrations in working under foreign political and legal constraints, and confusion in facing new international economic changes depends not only on intellectual strength and emo tional maturity, but also on cross-epistemological understanding. Many of the managers who are sent to overseas posts from firms renowned for superb human management fail miserably. Physicists who created new theories a decade ago become obstacles to still newer theories. People with excellent knowledge of foreign cultures or scientific paradigms still fail. Their failures stem from the fact that survival in today's world requires a new ability to relate seemingly unrelated aspects of our life, for the task of which our established classificational way of thinking is no longer adequate. We need to make use of new mindscape types (Maruyama, 1979b, 1980). They are epistemological types rather than personality types, value systems, or paradigms. Mindscape types differ from individual to individual. Firms as well as countries vary in their mainstream mindscape type. Even though all


and respect for all ethnic and cultural formations, of which sought to establish equality. Finally, the regulation of experiments on the human body, while requiring the voluntary consent of the subject. The development of the second ideal in the form of cultural relativism, did not fail to clash with the first and third ideals.2,3 On the one hand the Universalist claims of ethics related to human rights, does not sit well with the cultural relativity of values. Moreover, respect for the human body and the person are often contradicted by numerous regional customs. Let's try to understand what the historical and theoretical foundations of cultural relativism are. Then try to assess the conceptual content of ethical relativism. Finally, analyze the type of reports that anthropology has with bioethics.


Abstract We derive the 3D-NLTE lithium abundance in the solar photosphere from the Lii line at 670 nm as measured in several solar atlases. The Li abundance is obtained from line profile fitting with 1D/3D-LTE/3D-NLTE synthetic spectra, considering several possibilities for the atomic parameters of the lines blending the Li feature. The 670 nm spectral region shows considerable differences in the two available disc-centre solar atlases, while the two integrated disc spectra are very similar. We obtain A(Li)3D–NLTE = 1.03. The 1D-LTE abundance is 0.07 dex smaller. The line-lists giving the best fit for the Sun may fail for other stars, while some line-lists fail to reproduce the solar profile satisfactorily. We need a better knowledge of the atomic parameters of the lines blending the Li feature in order to be able to reproduce both the solar spectrum and the spectra of other stars. An improved line-list is also required to derive reliable estimates of the isotopic Li ratio in solar-metallicity stars.


AMERICAN GEOPHYSICAL UNION MEETINGSAN FRANCISCO-- Topics ranging from the atmosphere to the inner Earth were served up at the annual fall meeting of the American Geophysical Union here last month. Below, we report two surprising new ideas on how the solid Earth interacts with the atmosphere and with the water on its surface: why Earth hums and how a river may be able to raise a mountain.


This research aims to understand the relationship between parenting and political formation in the privileged social classes of Bogota between the 60s and 70s, starting from the life story of Patricia Lara Salive. This purpose was sought through the study of four key concepts: family, parenting, education and political formation.
Drawing on a hermeneutical and reflexive perspective this research seeks to understand this woman's childhood, as well as how it influenced her later political and journalistic work, from a reflexive and hermeneutical perspective. Based on her own narrative of her childhood story and a bibliographical collection, this project aims to understand what it meant to belong to the privileged social classes of Bogota at that moment, what situations or problems it implied and, most importantly, how political formation during childhood was.


A common procedure to pattern transparent conductive oxides (TCO) for monolithic series connection of thin-film solar modules is to use an infrared (IR) laser incident from the glass side. However, for cheaper opaque substrates this standard procedure cannot be applied and the films need to be ablated directly from the film side. In this article we used two Nddoped solid state pulsed lasers to pattern as-deposited in-house aluminum doped zinc oxide (ZnO:Al) thin-films from the film side. One IR laser with a wavelength of 1064nm (photon energy less than the band-gap of ZnO) and one UV laser with a wavelength of 355nm (photon energy larger than the band-gap of ZnO) were used. For single pulses a smoother ablation of ZnO was obtained with the UV laser compared to the IR laser. Furthermore, using the UV laser we obtained craters with a lower rim and less material melt. The ablation thresholds were determined with three different methods. The ablation threshold of ZnO for the IR is larger than for the UV. The differences in ablation thresholds are explained by the differences in absorption coefficients of the ZnO for the IR and UV. Both wavelengths can achieve good electrical separation even after deposition of a highly conductive µc-Si:H p-layer. In order to compare the various laser processes we prepared 10cm×10cm µc-Si:H modules on ZnO. We obtained comparable results for modules patterned from the film-side and modules patterned with the standard process.


We have made an attempt to trace the most effective ways of training applicants for entry that provide successful perspectives for further studies at university. We have also tried to reveal the reasons for high efficiency of these forms of training. The definition of special purpose components of training applicants for entry provided an experimental research algorithm of the effectiveness of its forms and methods of studies during a five-year course at university.


In this work we extensively apply the EHNS postulation to neutrino oscillation problems. Namely, we try to apply quantum mechanics violation (QMV) effects induced by the quantum gravity of black holes to understand neutrino oscillation phenomena. In addition to the original EHNS postulation, especially, the Lorentz transformation property of QMV is taken into account. The possibilities for observing such effects in neutrino experiments (in progress and/or accessible in the near future) are discussed. Of them, an interesting feature is outlined. [S0556-2821(99)05113-9].


Formation and assembly of monodispersed calcite (CaCO3) dots of diameters 6−10 nm using a zwitterionic phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayer as template at a two-dimensional interface is reported here. We utilized penetration of Ca2+ at lower surface pressure (π) into the DPPC monolayer, governed by a single exponential association method. In situ surface pressure (π)-area (A) isotherms as well as compressibility (β) analysis reveal a positive association of Ca2+ with DPPC. The natural exposure of the resultant monolayer to air results in formation of single crystalline CaCO3 nanodots. HRTEM and SAED techniques have been used to study the crystal structure of the resultant CaCO3 nanodots incorporated within the lipid monolayer.


The relativistic kinetic theory of linear transport is worked out within the framework of a new moment method. A complete analytical study of the transport in a two‐temperature inhomogeneous magnetized fusion plasma is given. The transport relations and coefficients are derived from the kinetic equation with the full relativistic Beliaev–Budker collision operator and the impact of relativistic effects on the confinement are investigated.


A Dissertation Submitted in Partial Fulfillment of the Requirements for the
Degree of Master of Science in Economics of Mzumbe University, Morogoro.
2013


(57) Abstract: The present invention is demonstrated to have non-insulin dependent diabetes mellitus (NIDDM or Type II diabetes) oral antihyperglycemic activity in diabetic ob / ob and db / db mice, an animal model of It relates to a novel compound that is. These compounds, in [formula represented by the formula (I), R


Objective A method of capillary GC with headspace sampling was set up to determine chloroform and tetrachloromethane in drinking water.Methods The special DB-624 capillary column was used for GC with headspace sampling. Results The correlation coefficients were 0.999 and the values of RSD were less than 10%,the recovery rate was in the range of 97.5%-103.3%.The range of linearity was 2.0-10.0 μg/L and 1.0-5.0 μg/L,and detection limit was 0.02 μg/L and 0.003 μg/L for chloroform and tetrachloromethane respectively.Conclusion The method is sensitive,accuracy and simple for analyzing chloroform and tetrachloromethane in water.


To the Editor: In the very important report published in Chinese Medical Journal,[1] a 50-year-old male patient, stented with a bare metal stent followed by 3 overlapping drug-eluting stents, developed anaphylactic reaction following a bee sting that was treated with intravenous 0.1 mg epinephrine at a 1:100,000 together with intravenous methylprednisolone, chlorpheniramine maleate, and ranitidine. He developed, immediately after, an anterior wall myocardial infarction, and subsequent coronary arteriography revealed total occlusion in the proximal left anterior descending stent and 90% stenosis with tissue growth in the mid-stent. The authors concluded that the acute myocardial infarction occurred due to acute stent thrombosis caused by exogenous epinephrine administration. This report, however, raises important questions related to the cause and pathophysiology of these events.

First, could bee sting anaphylaxis be aggravated by concurrent anti-allergic therapy in atopic diathesis individuals? The described patient was given intravenously, apart from epinephrine, methylprednisolone, chlorpheniramine maleate, and ranitidine. These 4 drugs that are given to treat anaphylaxis have been incriminated, paradoxically, as inducing mild or severe allergic reactions! Indeed, most epinephrine preparations contain sulfite as a preservative and antioxidant, which itself may trigger anaphylaxis in atopic individuals.[2,3] We must always bring in mind that allergens have additive effects and the more allergens an atopic patient is exposed to, the easier and quicker anaphylactic shock and Kounis syndrome appear.[3]

Second, the administration of epinephrine was the cause of stent thrombosis or the anaphylactic reaction? The described patient was stented with a bare metal stent followed by 3 overlapping drug-eluting stents. Bare metal and drug-eluting stents have components namely stainless steel that is a combination of nickel, chromium, titanium, manganese, molybdenum, polymer coating, and eluted antiproliferative drugs such as paclitaxel, zotarolimus, and accompanying antiplatelet therapy that constitute an allergenic complex. This allergenic complex embedded in the coronary intima is applying continuous, persistent, and chronic hypersensitivity inflammation able to induce stent thrombosis manifesting as the Kounis hypersensitivity coronary syndrome.[4] Several reports have shown that stents attract, such as magnet eosinophils and mast cells that release inflammatory mediators locally and in the systemic circulation able to induce coronary spasm and stent thrombosis. For example, acute myocardial infarction, in the stented area, manifesting as Kounis syndrome has coincided with allergic reactions from contrast material, insect and larvae stings, nonsteroidal anti-inflammatory agents, and even with allergy to clopidogrel the drug that is given to prevent stent thrombosis![5,6]

Third, can we always give epinephrine intravenously? Epinephrine is the cornerstone of treatment for anaphylaxis but it can aggravate the ischemia, prolong QTc interval, promote platelet aggregation, and induce coronary vasospasm and arrhythmias. According to the current guidelines, there is no absolute contraindication to epinephrine use in anaphylaxis. However, the use of intravenous epinephrine is still controversial in severe allergic reactions. It should be considered in patients with severe hypotension or cardiac arrest who do not respond to aggressive fluid resuscitation. Intramuscular use of epinephrine is the safer and preferred route of administration unless the patient has severe anaphylaxis.[7]

All above support the view that the described patient's acute myocardial infarction due to stent thrombosis following the intravenous epinephrine for bee sting-induced anaphylaxis was due to Kounis syndrome rather than to intravenous epinephrine administration.

Financial support and sponsorship
Nil.

Conflicts of interest
There are no conflicts of interest.


Measurements characterizing spatial mode filtering of mid-infrared (mid-IR) laser beams using hollow core fiber optics are presented. The mode filtering depends strongly on the fiber diameter, with effective mode filtering demonstrated with bore diameters of d = 200 μm and 300 μm. In addition to mode filtering, beam profile measurements also demonstrate the strong dependence of the mode quality on the fiber coupling conditions. As predicted, optimal coupling is achieved using relatively slow optics that produce focused spots that nearly fill the fiber diameter. Examples of the utility of using hollow fibers for mode-filtering to improve molecular spectroscopy experiments are also discussed.


Abstract The use of in situ hyperspectral reflectance and bio-physical measurements has been increasing in forestry. Due to limited physical accessibility in a forest environment, most of the reflectance measurements of trees are acquired at a leaf or bunch of leaves level. A few radiative transfer models are available for upscaling leaf spectra to canopy level. While these models are sophisticated, they retrieve canopy spectra based on certain assumptions. We propose 'semi-empirical model for upscaling leaf spectra (SEMULS)' which upscales in situ leaf spectra to canopy level based on the relationship between leaf spectra and its bio-physical parameters. The performance of the model has been quantitatively validated by comparing the upscaled canopy spectra with spectra from – CHRIS hyperspectral imagery acquired concurrently and from the PROSAIL model. Results indicate that the SEMULS retrievals are comparable with image spectra and PROSAIL with additional advantages of not requiring scene-dependent geometric-radiometric parameters and assumptions.


This critical-reflective study has the goal ofana/yzing the health care practices in the Fami/y Health Teams, and ofdistinguishing the models of health care ...


Optical segments based flexible systems are the key for the development of futuristic advanced wearable devices for health monitoring, robotics, and ultraprecision positioning in industrial applications. Here, we have demonstrated an processed optical microfiber based multifunctional sensing system, which overcomes the various limitations of most widely reported electronics and material-based flexible devices. By optimizing the position of the post processed microfiber configuration in optimized Polydimethylsiloxane (PDMS) thickness and controlling the interference between the fundamental mode and higher order modes of microfiber to form and tunable interference pattern, we are able to make an efficient, simple, flexible and economical optical wearable vector bending system with a sensitivity as high as 1.01nm/degree. In addition, this skinmountable sensing sensor shows a remarkable and ultrasensitivity of -3.07 nm/oC. This ultrahigh sensitivity, mechanical robustness, with the excellent flexible and biocompatible nature also makes this sensing system a dominant candidate for wearable medical devices for elder-care facilities, physioclogical monitoring, athletic training, and rehabilitation program.


It is shown that selective single-transition cross-polarization (ST-CP) may be achieved in four-level systems such as encountered in NMR (nuclear magnetic resonance) of scalar-coupled two-spin systems (for example, 15N–1H groups in peptides), by employing two selective resonant fields applied to a pair of connected transitions with RF amplitudes much weaker than the separation of the parallel transitions (e.g., the scalar coupling constant JNH). The transfer benefits from differential line narrowing due to interference between the 15N chemical shift anisotropy and 15N–1H dipolar coupling, which is clearly observed in 15N-labeled human ubiquitin at 600 MHz.


In e-learning area, the content development method is one of the most important research topics. This paper proposes a presentation method of visual contents (a text, a still image) in synchronization with narration (sound content) and a pointer to make the efficiency of the resource allocation of cognitive memory capacity increase, and make the transmitted amount of information maximize, based on a human's cognitive-information-processing model "dual channel model." Under various contents presentation environment {(1)narration, (2) text (with narration / without narration), (3) still images, (4) still images + text (with narration / without narration), (5) video, and (6) video + text} in e-learning, we performed some control experiments (measure the point of fixation for e-learning students by an eye mark recorder, memorization and a contents understanding test and the questionnaire) with or without pointer. The results showed the validity of this model and the effectiveness of the proposed content development method in e-learning.


Correctness conditions for concurrent objects describe how atomicity of an abstract sequential object may be decomposed. Many different concurrent objects and proof methods for them have been developed. However, arguments about correctness are conducted with respect to an object in isolation. This is in contrast to real-world practice, where concurrent objects are often implemented as part of a programming language library (e.g., java.util.concurrent) and are instantiated within a client program. A natural question to ask, then is: How does a correctness condition for a concurrent object ensure correctness of a client program that uses the concurrent object? This paper presents the main issues that surround this question and provides some answers by linking different correctness conditions with a form of trace refinement.


ABSTRACT To investigate pedestrian exposure when only pedestrian-crash data are available, the quasi-induced exposure method is used to identify the factors that contributed to pedestrian-vehicle crashes in Las Vegas from 2004 to 2008. The results show that overall crash severity, light conditions, and weather conditions are potentially risky factors in pedestrian crashes, and the time of day or day of the week are less risky. Multiple-correspondence analysis (MCA) is then used to investigate how pedestrian crash severity is influenced by the interactions among a range of variables. The results indicate that among instances of pedestrian-vehicle crashes cases of property damage only tend to occur during off-peak daytime hours and under dark or dawn light conditions in clear weather. Crashes resulting in injuries usually occur during weekday peak hours in daylight and under rainy conditions. Most fatal crashes occur during off-peak hours, at night on the weekends.


Adaptive Optics (AO) has revealed as a very promising technique for high-resolution microscopy, where the presence of optical aberrations can easily compromise the image quality. Typical AO systems however, are almost impossible to implement on commercial microscopes. We propose a simple approach by using a Multi-actuator Adaptive Lens (MAL) that can be inserted right after the objective and works in conjunction with an image optimization software allowing for a wavefront sensorless correction. We presented the results obtained on several commercial microscopes among which a confocal microscope, a fluorescence microscope, a light sheet microscope and a multiphoton microscope.


Enzymatic thermal switch: The bacterial 4-methylideneimidazol-5-one (MIO)- dependent enzymes AdmH and EncP are shown to display remarkable thermal bifunctionality: they act as mutases (blue graph) at lower temperatures but with lyase (red graph) activity predominant at higher temperatures. This temperature-dependent switch in enzyme class also explains how these two similar enzymes can fulfill different catalytic functions in secondary metabolisms.


Book Citations: Authors, Title, HemaSphere, 2023;7(S3):pages. The individual abstract DOIs can be found at https://journals.lww.com/hemasphere/pages/default.aspx. Disclaimer: Articles published in the journal HemaSphere exclusively reflect the opinions of the authors. The authors are responsible for all content in their abstracts including accuracy of the facts, statements, citing resources, etc. 1268 observed the persistence of cell lineages with specific mutations (such as non-classical monocytes and CD8+ effector T-cells) after the treatment with this DNA demethylation agent.


Summary In Portugal the environmental and sustainable issues are progressively emerging in building constructions and sustainable building assessment. The design of Portuguese environmental assessment system involve the study of the actual systems, such as LEED, BREEAM, HQE, CASBEE and GB Tool, a proposal of a first version, the test of those systems to specific cases and in the future a sub sequential critical assessment of the strongest and weakest points of those applications. From this process results, as a main conclusion, the possibility and interest of effective application to Portugal of such systems, and also the strong need to adjust them, in order to promote their application to different situations. Based in those insights it was designed a system derived from those referred above. The proposed system, object of this paper, have the name of LiderA, acronym from the Portuguese designation Liderar pelo Ambiente, which mean try to improve and leader trough the Environment. The system aims to be general, operational, and flexible, and must involve several phases, from project to construction, operation and deconstruction. It can also be used as a support to project design and in management, as a continuous tool to promote environmental performance.


In the UK in 2017, 9% of pupils aged 11–15 reported having drunk alcohol in the previous week, which is the lowest rate since the 1980s. Illegal drug use in the previous year reported by 15-year olds halved between 2001 and 2014. Despite these promising figures, adolescence is deemed to be decisive for future biopsychosocial development and performance. Initiation during adolescence may therefore have long-term implications, affecting mental performance and educational outcomes. This article focuses on patterns of drug misuse in teenagers. The warning signs of drug misuse and useful assessment tools are also introduced. For the purposes of this article, alcohol will be defined as a drug.


In two experiments we show that the context in which groups are perceived influences how they are judged in a compensatory manner on the fundamental dimensions of social judgment, that is, warmth and competence. We manipulate the type of country (high in competence and low in warmth vs. high in warmth and low in competence) to which a target country is compared. Our data show that the target country is perceived as wanner and less competent when the comparison country is stereotypically high (vs. low) in competence and low (vs. high) in warmth. We also found compensation correlationally across targets and across dimensions in that the higher the comparison country is rated oil one of the two dimensions, the higher the target country is rated oil the other Compensation effects are shown to a to affect judgments of both the ingroup (Experiment 1) and all outgroup (Experiment 2). Our results shed new light oil context effects in group judgments as well as oil the compensatory relation of the two fundamental dimensions of social judgment. Copyright (C) 2008 John Wiley & Sons, Ltd.


Objectives. Hysterectomy represents the current routine therapy for high‐risk endometrial precancers. More sophisticated methods are needed for treatment decision among women who want to preserve fertility and seriously ill patients. Among women diagnosed with high‐risk hyperplasia, approximately 40% show signs of endometrial cancer in the hysterectomy specimen. Thus, more sophisticated methods are needed to select the women at risk. Setting. University Hospital of Tromsø, Regional Center for Gynecological Oncology in northern Norway. Population. From 1999 to 2004, 258 consecutive patients had endometrial hyperplasia diagnosed by D‐score; 57 among these were high‐risk cases (D‐score < 0) and 10 had coexisting endometrial carcinoma. No further cancers were detected after long‐term follow‐up (4–10 years). Design. From the initial histological specimens, material from the 10 patients with cancer and from the 13 cases without cancer (high‐risk D‐score < 0) was analyzed with selected histomorphometric (architectural and nuclear) and immunohistochemical (hormone receptors and apoptotic) features blinded to the investigator. Method. Original slides were used for computerized histomorphometry (4‐class rule and related procedures). Serial sections from the paraffin embedded material were used for immunohistochemical investigations. Immunohistochemical expression in glands and stroma was evaluated by the semi‐quantitative H‐score (ER‐α, ER‐β, PR‐A, PR‐B, RCAS‐1, Bcl‐2, BAX, and Caspase‐3). Results. The histomorphometric 4‐class rule differentiates between presence and absence of cancers with a sensitivity of 80% and specificity of 77%. Several morphometric and immunohistochemical features were significantly different in cases with cancer and hyperplasia. Conclusions. Histomorphometry seems superior in predicting coexistent carcinoma in high‐risk endometrial hyperplasia and should be considered for clinical use.


Aim\ To diagnose faults of a working diesel engine. Methods\ Using the analysis of the Correlation of ABO mode based on grey system theory. Results\ Working order and fault order of working diesel engine was diagnosed. Conclusion\ The analysis of the Correlation of ABO mode is valid to diagnose faults of working diesel engine.


Compared with the traditional teaching and clinical skills training methods, virtual simulation training is a new practical teaching mode, which can reflect the characteristics of the specialty itself and the nature of the discipline. Virtual simulation training has many advantages in basic nursing teaching, which is helpful to cultivate clinical thinking skills and professional learning ability. Virtual simulation training is mainly based on computer technology as the core of the teaching, which can guarantee the virtual relief of hearing, visual and tactile blending, allowing students to have a strong sense of reality, experience, and effective protection of reality and virtual fusion training. Introducing this high-tech technology into nursing teaching can help to stimulate students' individual motivation and interest, and enhance the fun and heart of the classroom. Ensure the teaching effect can be improved to promote the updating and transformation of basic nursing teaching mode. This paper mainly explores the application progress of virtual simulation training in basic nursing, and understands the effect of virtual simulation training in basic nursing teaching.


In 2012, the City University of New York undertook to examine whether online tutoring would be helpful to remedial algebra students. The research study was done in the spring 2012 semester at the Borough of Manhattan Community College (BMCC). The research question was two-fold: (a) Does online tutoring help improve pass rates among remedial algebra students? and (b) Do remedial algebra students find that online tutoring is helpful? A random sample of eight sections of Elementary Algebra was chosen from the 112 sections of that course offered in the spring semester. This amounted to a total of 195 students in the research sections, with 2,521 remaining students in the control (nontreatment) sections. All students in the eight treatment sections were given access to the Brainfuse online tutoring system. Midterm scores, final exam scores, and opinion surveys were collected. An overwhelming proportion of those who used the service found it helpful (94.7%) and would recommend it to a friend (100.0%). However, the pass rates in the study were nearly the same for the treatment and control groups, and a logistic regression analysis, comparing two statistically matched cohorts, showed no significant differences. One issue was that the sample of those who chose to use the service was small. Also, many of those who needed the most help were not the ones who used the service. It may be that in terms of improving pass rates, outreach and counseling for students could be more efficacious than simply offering a tutoring service.


Monolithic InP/GaInP quantum dot passively mode-locked lasers are realised for the first time, emitting in the 730 nm waveband. Devices with total cavity length between 2 mm and 3.5 mm, with uncoated cleaved facets, and saturable absorber (SA) sections representing approximately 20% of the total cavity length have been found to Q-switch, mode-lock or both, depending on operating regime. The influence of bias conditions on the characteristics of lasers with a 3 mm cavity length have been explored, resulting in generation of pulses at 734.7 nm with pulse repetition rates of 12.55 GHz and pulse durations down to ≈6 ps.


Criminal law theorists overwhelmingly agree that for some conduct to constitute punishment, it must be imposed intentionally. Some retributivists have argued that because punishment consists only of intentional inflictions, theories of punishment can ignore the merely foreseen hardships of prison, such as the mental and emotional distress inmates experience. Though such distress is foreseen, it is not intended, and so it is technically not punishment. In this essay, I explain why theories of punishment must pay close attention to the unintentional burdens of punishment. In two very important contexts—punishment measurement and justification—we use the term "punishment" to capture not only intentional harsh treatment but certain unintentional harsh treatment as well. This means that the widely accepted view that punishment is an intentional infliction requires substantial caveats. It also means that any purported justification of punishment that addresses only the intentional infliction of punishment is woefully incomplete.


The construction of a simple and inexpensive laser power meter is described. The laser power is monitored using a calorimeter sensor which is based on the use of commercial platinum resistors. In this design, the use of volume absorbing glass enables the meter to withstand peak power densities in the region of 100 MW cm-2 and average powers in excess of 10 W at 1.06 mu m. Average powers down to less than 1 mW can also be readily measured.


The focus of the article is the issue of studying intonation structure of vocal form of a language in folk music and its reference to the intonation features in a language system. The article presents the results of contrastive analysis of folk songs intonation in Russian and German from the perspective of phonological approach.


- The major concern of 21st century is it increasing green house gases emissions which are severely harming the planet. Major steps are taken all over the world to counter the problem. The area which is in lime light currently is the automobile sector as it is greatly responsible for emission of a major portion of green house gases. The vehicles we use today are run by conventional fuel which pollutes the environment. So several attempts are made all over the globe to replace the conventional fuel vehicles by electric vehicles (EVs). But the attempts made to replace the conventional fuel vehicles with electric vehicles were not much successful. Although many companies have launched electric vehicles but they were unable to get popular among people of the world. There were many problems related to electric vehicles which were responsible for this. The major loophole was not having a proper electric vehicle charging infrastructure. Only home charging systems are available in modern day electric vehicle charging which limits people from using electric vehicles. So a proper and well defined plan is proposed in the paper. Motivated by the above mentioned reasons, here this paper is addressed which aims on modeling and integration of electric vehicle charging system. The system designed here is will be connected in the already developed charging stations. The system will monitor the charging percentage and identify the user through a special identification method which will be unique for every user. Each system connected to each charging station will also have a unique identity in itself. The charging stations throughout the city will be connected with this system and the system will centralize them to a common server. Thus making it a smart system which can be implied in big cities and will be a major breakthrough in deciding the future scope of the electric vehicles in the country and also throughout the world. _____________________________________________________________________________________________________


"Concept of youth socialization: norms, deviation, socializing trajectory" (by Antonina Kovaliova) is based on decade-long individual and collective research, which in sum permits the author to postulate certain innovative concepts and notions in the field of youth studies. This is, first of all, a concept of socialization norm. On the societal level this norm might be arguably seen as a sum total of rules for translating social norms and cultural values from generation to generation. Then, this is typology of socialization processes and a characteristic of deviating socialization. Finally, this is specifics and trajectory model for youth socialization. Socialization trajectory, so Kovaliova, might be academically considered as an integral indicator permitting to grasp crucial objective and subjective aspects of youth socialization process making.


The data in computer is lost because of the subjective and objective reasons.To solve this problem,an implement scheme of data recovery on Windows NTFS file system is proposed.The structure of NTFS file system on disk,file recode and several key of file attributes are introduced.By analyzing the change of the attribute value in file recode after the file has been deleted,the concrete implement of data recovery is illustrated.


Heritage Areas are areas of great natural, geological, aesthetic and cultural value. They have an important history and keep the traditions alive. Geological and natural processes from the early past to the present have evolved and contributed to the creation of Heritage Areas, so today we experience the heritage of exceptional cultural, natural and scenic resources.

The sustainable management of Heritage Areas focuses on preserving areas of cultural and natural significance for the future generations, while encouraging local communities to continue living and working in the region. These areas deserve special prevention and should be included in the National Systems of Protected Areas in accordance with international conventions and legal frameworks.

The framework for the management of Protected Areas in Greece has changed recently. Four new categories of protected areas now exist. Biodiversity Protection areas, National Parks, Wildlife Refugees, Protected Landscapes and Protected Natural Formations. This research supports the integration of Heritage Areas into the category of Protected Landscapes. By the implementation of the framework, the main advantage will then be to achieve real protection of an area of monuments, cultural importance, great natural value and beauty.


A 30 year old physiotherapist had a long history of mild intermittent anterior knee pain. Five days prior to presentation she had been driving her manual car in heavy traffic and noticed that with repeated depression of the clutch her left knee developed pain and swelling. The knee pain and swelling had persisted despite rest and she was unable to fully straighten her knee. She presented on crutches. She had no previous episodes of knee swelling and no other joint problems.


The purpose of the work. This article is dedicated to the problem of implementation of cultural anthropological strategy and the method of oral history in the modern theater studies. The author tries to show how this method can be appropriate and useful in the context of the research of creative activity of Odessa Musical Comedy Theatre named after M.Vodyanoy and its correlation with the Odessa urban myth and urban identity ("odesskost"). Methodology. The methodological basis of the research is the anthropological developments of well-known anthropologists – M.Koul, K.Fox, T. Richardson, as well as the basic concepts of the leading Anglo-American experts in oral history (P.Tompson, L.Shopes, J.Moyer and I. Rety). Scientific novelty. The above-mentioned strategy and methods are used for the first time in the context of the similar material. It is emphasized, that due to their indispensability and importance it became possible to investigate not only the relationship of the theater and the Odessa urban myth, but to make a detailed reproduction of fleshed-out picture of the past – the history of development and formation of the Musical Comedy Theater on the background of the general history of the Soviet and modern Odessa, to discover new facts from the biography of actors, to reconstruct performances, withdrawn from the theater playbills, еtc. Conclusions. The author comes to the recognition of the effectiveness of the proposed strategies and methods, as well as the understanding of the research perspective of the issue.


The invention provides an intelligent user operation discovery method of a file system, which comprises the steps of: using a node mark of the file system as a unique mark, and comparing a node of a local synchronous catalogue with the file system node when the former synchronization operation is successful so as to identify user operation behaviors. In particular, the method in the invention comprises the steps of: using the node mark ino number of the file system as the unique mark, comparing the ino number with the change of paths and contents of the corresponding nodes to identify such user operations as newly adding, deleting, renaming, moving and file content amending, and the like. The method of comparing by the node mark of the file system is combined with a traditional directory tree comparison method to discover the user operation behaviors. The file synchronous system of the invention is used for reducing the synchronous operation quantity and reducing the dissipation of network flow.


The present invention is by electrostatic spinning of a solution containing an alcohol-based, solvent-based metal dissolved or semimetal or nonmetal alkoxide, a method of manufacturing an inorganic nanofibres. The solution is stabilized by chelating agent to prevent hydrolysis of the alkoxide, the solution may be mixed with an alcohol solution of poly (vinyl pyrrolidone) after homogenisation the obtained solution is then electrospun successively is moved to the electrostatic field which is effected, resulting organic - inorganic nanofibres are produced, outside then the fibers spinning device, an air atmosphere, is calcined at a temperature of 1300 ° C. from 500 ° C. .


This paper is aimed to present the performance of a B-spline neural network controller to regulate the reactive power provision from synchronous machines. Due to the fact that power systems possess non-stationary parameters and changing settings, adaptive control schemes are preferred. Control technology must ensure its performance in terms of power system's practical operation to address the diversity of loads connected to maximize the available resources. The B-spline neural network is a convenient tool to implement the adaptive voltage regulator, with the possibility of carrying out this task on-line considering the systems' non-linearities. The reactive power contribution is based on the premise that each machine must provide an amount according to its nominal operating capacity. The applicability of the proposal is demonstrated by simulation of a multi-machine power system.


Monte Carlo simulation is now a well established method for studying semiconductor devices and is particularly well suited to highlighting physical mechanisms and exploring material properties. Not surprisingly, the more completely the material properties are built into the simulation, up to and including the use of a full band structure, the more powerful is the method. Indeed, it is now becoming increasingly clear that phenomena such as reliabil ity related hot-electron effects in MOSFETs cannot be understood satisfac torily without using full band Monte Carlo. The IBM simulator DAMOCLES, therefore, represents a landmark of great significance. DAMOCLES sums up the total of Monte Carlo device modeling experience of the past, and reaches with its capabilities and opportunities into the distant future. This book, therefore, begins with a description of the IBM simulator. The second chapter gives an advanced introduction to the physical basis for Monte Carlo simulations and an outlook on why complex effects such as collisional broadening and intracollisional field effects can be important and how they can be included in the simulations. References to more basic intro the book. The third chapter ductory material can be found throughout describes a typical relationship of Monte Carlo simulations to experimental data and indicates a major difficulty, the vast number of deformation poten tials required to simulate transport throughout the entire Brillouin zone. The fourth chapter addresses possible further extensions of the Monte Carlo approach and subtleties of the electron-electron interaction. Monte Carlo Modeling for Electron Microscopy and MicroanalysisOxford University Press This book provides a thorough introduction to, and review of, the modelling of semiconductor devices using the Monte Carlo particle method. Beginning with a review of the essential physics of solid-state devices and electron transport, Dr Moglestue then explains the particle modelling technique with applications to semiconductor devices using illustrative examples from actual experience. The author draws on a wealth of experience in the field to provide a tutorial and reference source for device physicists, electronics engineers and graduate students wishing to apply Monte Carlo techniques. This work establishes a framework for Monte Carlo simulations of complex, modulated electron fields produced by Varian's TrueBeam medical linear accelerator for investigations into modulated electron radiation therapy (MERT) and combined modulated photon and electron radiation therapy (MPERT). Both MERT and MPERT have shown potential for reduced low dose to normal tissue without compromising target coverage in the external beam radiation therapy of some breast, chest wall, head and neck, and scalp cancers. This reduction in low dose could translate into the reduction of immediate radiation side effects as well as long term morbidities and incidence of secondary cancers.Monte Carlo dose calculations are widely accepted as the gold standard for complex radiation therapy dose modelling, and are used almost exclusively for modelling the complex electron fields involved in MERT and MPERT. The introduction of Varian's newest linear accelerator, the TrueBeam, necessitated the development of new Monte Carlo models in order to further research into the potential role of MERT and MPERT in radiation therapy. This was complicated by the fact that the field independent internal schematics of TrueBeam were kept proprietary, unlike in previous generations of Varian accelerators.Two approaches are presented for performing Monte Carlo simulations of complex electron fields produced by TrueBeam. In the first approach, the dosimetric characteristics of electron fields produced by the TrueBeam were first compared with those produced by an older Varian accelerator, the Clinac 21EX. Differences in depth and profile characteristics of fields produced by the TrueBeam and those produced by the Clianc 21EX were found to be within 3%/3 mm. Given this information, complete accelerator models of the Clinac 21EX, based on its known internal geometry, were then successfully modified in order to simulate 12 and 20 MeV electron fields produced by the TrueBeam to within 2%/2 mm of measured depth and profile curves and to within 3.7% of measured relative output. While the 6 MeV TrueBeam model agreed with measured depth and profile data to within 3%/3 mm, the modified Clinac 21EX model was unable to reproduce trends in relative output as a function of fieldsize with acceptable accuracy.The second approach to modelling TrueBeam electron fields used phasespace source files provided by Varian that were scored below the field-independent portions of the accelerator head geometry. These phase-spaces were first validated for use in MERT and MPERT applications, in which simulations using the phase-space source files were shown to model depth dose curves that agreed with measurement within 2%/2 mm and profile curves that agreed with measurement within 3%/3 mm. Simulated changes in output as a function of field size fell within 2.7%, for the most part.In order to inform the positioning of jaws in MLC-shaped electron field delivery, the change in output as a function of jaw position for fixed MLC-apertures was investigated using the phase-space source files. In order to achieve maximum output and minimize treatment time, a jaw setting between 5 and 10 cm beyond the MLCfield setting is recommended at 6 MeV, while 5 cm or closer is recommended for 12 and 20 MeV with the caveat that output is most sensitive to jaw position when the jaws are very close to the MLC-field periphery. Additionally, output was found to be highly sensitive to jaw model. A change in divergence of the jaw faces from a point on the source plane to a 3x3 mm^2 square in the source plane changed the shape of the output curve dramatically.Finally, electron backscatter from the jaws into the monitor ionization chamber of the TrueBeam was measured and simulated to enable accurate absolute dose calculations. Two approaches were presented for measuring backscatter into the monitor ionization chamber without specialized electronics by turning o the dose and pulse forming network servos. Next, a technique was applied for simulating backscatter factors for the TrueBeam phase-space source models without the exact specifications of the monitor ionization chamber. By using measured backscatter factors, the forwarddose component in a virtual chamber was determined and then used to calculate backscatter factors for arbitrary fields to within 0.21%. Backscatter from the jaws was found to contribute up to 2.6% of the overall monitor chamber signal. The measurement techniques employed were not sensitive enough to quantify backscatter from the MLC, however, Monte Carlo simulations predicted this contribution to be 0.3%, at most, verifying that this component can be neglected. Transport of Energetic Electrons in Solids Proefschrift Penelope Monte Carlo and Density Functional Theory Simulation of Electron Energy Loss Spectra Monte Carlo Simulation of Electron Swarms in Monte Carlo Simulations of Electron Transport in Quantum Well Heterostructures Monte Carlo Modeling for Electron Microscopy and Microanalysis Ensemble Monte Carlo simulation of electron transport in AlGaAs/GaAs heterostructures Analysis of Electron Heat Transfer Via Monte Carlo Simulation Monte Carlo Device Modeling Applications on Parallel Computers A 3D model of a low voltage electron beam has been constructed using the ITS/ACCEPT Monte Carlo code in order to validate the code for this application and improve upon 1D slab geometry simulations. A line source description update to the code allows complete simulation of a


Aim. To study the ability of yeast RNA oligoribonucleotides (ORNs) and their complexes withD-mannitol to influence the conformation and thermal stability of interferon (INF) α-2b. Methods. The ability of oligoribonucleotide drugs to bind to INF α-2b was studied using its fluorescence quenching method. The effect of ORN drugs on protein stability was studied by analyzing the thermal stability of INF. To confirm their influence on the conformation of the INF, we investigated the spectra of circular dichroism. Results. The ORN complexes with D-mannitol, due to their better protein binding, have been shown to have a much higher effect on the conformation and thermal stability of interferon α-2b than ORN. ORNs and their complexes with D-mannitol also increase the thermal stabilization of interferon. The addition of ORN and ORN with D-mannitol to INF leads to a decrease in the content of α-helical components in the protein structure and an increase in β-components and unstructured parts of the protein molecule. Addition of the ORN complex: D-mannitol, unlike the ORN, changes the architecture of the tertiary INF structure. Conclusions. Therefore, the ORN complexes with D-mannitol have a much higher effect on the conformation and thermal stability of interferon α-2b than the parent drug ORN. The more specific binding of oligonucleotides can probably explain this in the presence of mannitol to the protein. ORNs and ORN complexes with D-mannitol also increase the thermal stabilization of interferon by 2 and 1.8 °C, respectively. The addition of ORNs and ORN complexes with D-mannitol leads to a decrease in the content of α- helical components in the protein structure and an increase in antiparallel β-sheets, β-turns, and unstructured elements. In the presence of mannitol in the ORN molecule, the structure of INF changes more intensively. Addition of ORN complexes: D-mannitol to INF, unlike ORN, changes the architecture of the tertiary protein structure from a 2-layer sandwich to an alpha-beta complex.Keywords: oligonucleotides; interferon; mannitol; secondary protein structure.


The purpose of this study is to seek the systematization of Korean language cognitive thinking domain. First, system-related term of cognitive thinking domain was established at thinking type and thinking subtype in order to eliminate confusion in using the system-related term. Next, the system-related term has been utilized in the critical review on previous study. Finally, the result of the critical review suggest several possibilities in the systematization of Korean language cognitive thinking domain. The possibilities are setting of realistic thinking, understanding thinking, logical thinking, critical thinking, creative thinking in terms of thinking type and setting of main fundamental thinking, main complex thinking in terms of thinking subtype and setting of individual thinking by thinking subtype. In addition, some thinking have been added. Based on this, the system of Korean language cognitive thinking domain was presented.


Objective To provide guidance for auricular reconstruction by using three-dimensional auricle and guide plate based on auricular image data of the healthy side, and the three-dimensional solid model was printed. Methods The virtual three-dimensional model of the auricle and guide plate of the affected side was established by segmenting, mirroring and expanding CT data from the healthy auricle using Mimics software, which was further imported into a 3D printer to produce a three-dimensional solid model for clinical applications. Results An individualized and delicated three-dimensional solid model of a reconstructed auricle and guide plate of the affected side was successfully produced. It was used in auricular reconstruction for finer carving and localization of the affected auricle. Conclusion The digital and solid three-dimensional model of the auricle and guide plate obtained by Mimics software and 3D printing technology, may contribute a lot to the fabrication and localization of the affected auricle in microtia surgery.


Because of the coming of knowledge economy age, the intellectual property rights have become the important input and competitive advantage of corporations. In the situation, doing technological life cycle forecasting can help corporations with their technologic environment analysis and designing strategies. The current study aims to compare the goodness of fit, forecasting power, and the correlation between goodness of fit and forecasting power of the two models. The research has got several conclusions: 1. There is no difference in goodness of fit between two models. 2. The forecasting power of logistic model is better than gompertz model in short tern. In long term gompertz model has batter forecasting power, but has lower stability. 3. The underestimated natural limit of growth will result in the inaccuracy of forecasting. 4. The correlation between goodness of fit and forecasting power of gompertz model is better than logistic model.


This study aims to analyze the effect of liquidity, asset management, leverage and dividend policy on firm value at Food and Beverages Companies listed on the Indonesia Stock Exchange. The type of research used is quantitative research because the data used is numbers while the nature of this research is descriptive research. The population in this study amounted to 30 Food and Beverages Companies listed on the Indonesia Stock Exchange. The research sample used is in the form of financial statements of Food and Beverages Companies listed on the Indonesia Stock Exchange with a total of 20 companies from 2016-2019. The results of this study indicate that the current ratio, total asset turnover, debt to equity ratio and dividend payout ratio have a positive and significant effect on firm value at Food and Beverages Companies


COVID-19 epidemic has affected many people across the world creating a health crisis around the globe. World Health Organization (WHO) recommends that covering face with mask is one of the best protection to minimize COVID infection. COVID-19 pandemic has forced governments across the planet to impose strict lockdowns to stop the spread of virus. Many health experts says that wearing facemasks while at public places clearly reduces the spread of the virus. A Machine Learning (ML) based face mask detection with face recognition and alert has been proposed. As part of this work, a face mask detector along with face recognition with CV and ML using Python has been developed. In this system, the input would be a real time input image via laptop webcam. Assuming if anyone is not wearing a mask, an automatic alert is generated and the respective person snapshot is sent to the admin e-mail.