Abstract : The continuous growing in systems/functions installed in the modern aircraft, imposed by the more and more demanding requirements in terms of performance and safety, is leading to the development and the application of new components and systems in the area of cockpit indication and automatic controller integration. The Cathode Ray Tubes (CRT) and other multifunction display technologies are rapidly replacing many of the dials, panels and gauges of the old cockpit. Artificial intelligence and high level automation are emerging in digital avionics. These systems would take over the crew in many cockpit management functions such as reconfiguration to compensate fault or execute emergency procedures. This paper analyzes the design and certification aspects related to the adoption of these new technologies and discusses some aspects of human factor engineering which become an integral part for the cockpit design, for the simbology and for the logic integration of the function within the automatic control and display system.


The article concerns the activity of the Irkutsk State University scientists and teachers, who participated in the Great Patriotic War. The article reveals their life, war's impact on their biographies, their contribution to the legal education renovation in the Eastern Siberia


Recently, the Italian legislator has realised two substantial regulatory interventions that are destined to produce significant impacts on corporate governance structures, drawing consequently the scholars' attention: we refer, on one side, to the introduction of benefit corporations (the so-called "società benefit") in 20151 and, on the other side, to the reform of the class action tool in 2019.2 Both regulatory interventions provide a number of important innovations. Indeed, the benefit corporations, while carrying out an economic activity and in addition to the purpose of gaining profits, are designed to pursue one or more purposes of common benefit and operate in responsible, sustainable and transparent manner towards people, communities, territories and environment, cultural and social assets and activities, institutions, associations and other stakeholders. It is clear that the pursuit of one or more benefit purposes has to be balanced by the directors with the profit purpose, that still represents the main aim of the corporation (which is not a "no profit" corporation), and the outcomes of this balancing activity could potentially affect the interests of the shareholders or of the stakeholders, depending on who of those 1 Benefit corporations have been introduced in Italy by Law December 28, 2015, n. 208. Many scholars have investigated the newly legal institute in the aftermath of the reform: see, in particular, Calagna (2016); Corso (2016); Gallarati (2018); Guida (2018); Lenzi (2016); Siclari (2016); Stanzione (2018); Ventura (2016). 2 The Italian reform of the class action has been enacted by Law April 12, 2019, n. 31 and will enter into force on April 19, 2020. Within the first scholars that have discussed on the main news of the reform, see, in particular, Consolo (2019); Pisapia (2019). "NEW CHALLENGES IN CORPORATE GOVERNANCE: THEORY AND PRACTICE" Naples, October 3-4, 2019 86 could argue to have been disadvantaged at the end: therefore, the possibility for the stakeholders to be granted with a direct legal action against the benefit corporation directors, based on a non-fulfilled benefit purpose claim, is the main issue to be investigated in the context of the benefit corporations.3 The above issue is strictly interrelated with the reform of the class action, which took place on April 2019 and that is going to enter into force on April 2020. Indeed, the new class action tool is designed to be available to all those who make claims for damages in relation to the infringement of "homogeneous individual rights" (as could be those pertaining to the stakeholders of a benefit corporation) and is not only reserved to consumers, like in the previous regulation. The above said innovation, together with the extension of the objective scope of the action, may contribute to render the class action the most popular tool to be employed to support the claims of the stakeholders in the context of benefit corporations. Therefore, the effective right for the stakeholders to sue directly the benefit corporation directors and the related recourse to the reformed class action tool (also considering the opportunities arising from the reform innovations) will be the target of the investigation we hope to develop through the paper to be presented at the International Conference in Naples.


Scaling relations are one of the hallmarks of nodal superconductivity since they contain information characteristic for gapless order parameters. In this paper we derive the scaling relations for the thermodynamics and the thermal conductivity in the vortex state of the A and B phases of the skutterudite PrOs4Sb12. Experimental verification of these scaling relations can provide further support for anisotropic gap functions which were previously considered for this material.


The objective of this study was to examine the influence of diabetes-related support in promoting aerobic activity in a sample of older African Americans. A secondary data analysis was conducted based on a diabetes self-management study of community-dwelling older African Americans. Logistic regression was conducted to examine the influence of diabetes-related support on aerobic activity. The final model demonstrated that there was a strong relationship between having diabetes-related support and aerobic activity, odds ratio =6.56, 95% confidence interval [2.14, 20.11]. The final model also demonstrated a significant influence based on the total number of chronic health conditions on aerobic activity, odds ratio = 0.63, 95% confidence interval [0.498, 0.802]. Findings suggest that older African Americans with Type 2 diabetes and other chronic health conditions may engage in physical activity if they have diabetes-related support from their family and friends.


Tax revenues play an important role in supporting the government to improve people's welfare through the construction of public facilities. Therefore, the government always tries to increase tax revenues from year to year. One of the improvements isstheeuseeoffinformationnanddcommunicationntechnologyyby using the e-tax system andde-filing. Research using the e-tax system and e-filing on tax in the pre-batam primary school by taking a sample of 100 taxpayers, using. Data analysis method uses descriptive techniques. Variable taxpayer compliance (Y) has a constant value of 6.196 tax-payer compliancce, thissfigure indicatess if the e-filling system (X1) and e-tax system (X2) is 0, then the value of tax compliance (Y) the constant value of 6.196 has a positive and significant effect. The e-filing system variable (X1) has a regression coefficient of 0.367 etax so that the increase in the variable e-filing system is 1 unit, then the value of the tax compliance variable will increase by 0.367 e-tax units with other variables considered constant. This shows the positive relationship between e-filing system and tax payment compliance and e-filing system variable (X1) has e-filing system regression coefficient variable of 0.50 e-filing so that the e-filing system incrementing variable is 1 unit, variable value taxpayer compliance will increase by 0.505 with other variables considered


Tertiary education comprises at least two phases, undergraduate and graduate studies. Often, the first year is regarded another, crucial phase where students familiarize with the study environment. It can be hypothesized that students' individual perceptions of learning and studying as well as the pedagogies they experience differ depending on their current study phase. Yet, differences between the phases in HE have rarely been investigated. To capture differences in student experiences in HE comprehensively, Jenert and Gebhardt (2010) have developed a framework describing Learning Culture in HEI. LC comprises a number of constructs on the three levels of the individual student, pedagogical interactions and the organization.
The study first aims to quantitatively describe differences in LC between the phases of HE within a university. Based on this analysis, a second goal is to develop a deeper understanding of how students manage the transitions between different phases by applying qualitative research methods.


Universality of the weak interactions is reviewed, with special emphasis on the origin of the Cabibbo theory of strange-particle βdecays and its role in the discovery of the unified Electroweak Theory. Achievements and present challenges of the Standard Theory of particles interactions are briefly illustrated. As a homage to Nicola Cabibbo, his leading role in the Roma school of theoretical physics and in the Italian science in general is reviewed. ∗ Extracted from "Universality of the Weak Interactions, Cabibbo theory and where


A process for producing an amorphous material at a low cost by efficiently removing Al and Ti which are causative of the deterioration of magnetic characteristics even when an inexpensive raw material such as Fe-B or scrap is used. In producing an iron-base amorphous material consisting of, by mass, 2 to 4% B, 1 to 6% Si and the balance Fe with unavoidable impurities, when the Ti or Al concentration of molten iron after the melting of the main raw material is 0.005% by mass or above, Ti and Al contained in the molten iron are removed through oxidation by the addition of an iron oxide source containing at least 55% by mass of iron to such an extent that the concentrations of both are lowered to below 0.005% by mass respectively, while when a main raw material whose composition has a Ti or Al concentration of 0.005% by mass or above is used, an iron oxide source containing at least 55% by mass of iron together with the main raw material is preliminarily charged into a melting furnace. ® KIPO & WIPO 2009


I. INTRODUCTION The purpose of this article is to explain why the federal government needs to limit the potential tort liability of Regional Transmission Organizations (RTOs) and owners of transmission lines used by RTOs for economic damages attributable to electricity outages and/or power quality disturbances. Section I describes RTOs and explains why they are critical to the successful performance of the restructured U.S. electricity market. Section II describes the liability limitations that all states have long applied to owners of electricity transmission lines and explains why those limitations have been critical to the successful performance of electricity markets. Section III describes the position of the Federal Energy Regulatory Commission (FERC) with respect to the need for federal liability limitations applicable to RTOs, i.e., federal limitations are not needed because state limitations are available. Section IV explains why federal limitations on the potential tort liability of RTOs and their members are essential for the successful performance of the restructured electricity market. 11. THE ROLE OF REGIONAL TRANSMISSION ORGANIZATIONS For several years, the FERC has been in the process of restructuring the United States' wholesale electricity market in an effort to improve its efficiency.1 The FERC has concluded that its ability to complete the process of socially-beneficial restructuring is critically dependent on the creation of RTOs.2 Each RTO would exercise complete control over the operation of the many transmission lines that comprise an integrated regional grid. It is a basic law of physics that electricity flows across an integrated grid in inverse proportion to the impedance on each line in the grid. As a result, a transaction that seems to require transmission of electricity just a hundred miles or so from point A to point B actually can effect the capability of the grid to accommodate other transactions as far as one thousand miles from A and B. Thus, for instance, a transmission transaction from Pittsburgh to Philadelphia might effect the capability of the grid to support electricity service to Boston, New York, Baltimore, and Washington. The ownership of the lines that form each integrated regional grid is extraordinarily fragmented. Twenty to fifty different utilities or governmental agencies each own lines in a typical regional grid. Traditionally, each owner (usually a vertically-integrated utility) has controlled the operation of its lines. The balkanized pattern of ownership and control of regional grids is inherently incompatible with efficient performance of the competitive wholesale market Congress instructed the FERC to create.' In an important series of orders issued between 1999 and 2001, the FERC concluded that RTOs are critical to attainment of the FERC's goal in creating an efficient wholesale electricity market. RTOs are voluntary associations in which each of the owners of transmission lines that comprise an integrated regional grid cedes to the RTO complete operational control over its transmission lines. The FERC summarized its RTO initiative in an order issued July 12, 2001: The Commission has been attempting to facilitate the development of large, regional transmission organizations since we issued Order No. 2000. We favor the development of one RTO for the Northeast, one RTO for the Midwest, one RTO for the Southeast, and one RTO for the West. Through their independence from market participants, RTOs can ensure truly nondiscriminatory transmission service and will instill confidence in the market that will support the billions of dollars of capital investment in generation and demand side projects necessary to support a robust, reliable and competitive electricity marketplace. RTOs are the platform on which our expectations of the substantial generation cost savings to American consumers are based. As multistate entities that operate entirely in interstate commerce, RTOs are necessarily subject to exclusive federal regulatory jurisdiction5 III. …


AIM:To observe the effect of bcl-2 gene transfection on the proliferation of human gastric epithelial cell GES-1. METHODS:The eukaryotic vector carrying the full length of bcl-2 gene and the neomycin resistance gene (pcDNA3/bcl-2) and the one only carrying the neomycin resistance gene (pcDNA3) were amplified and purified. The plasmid of pcDNA3/bcl-2 was used to transfect GES-1 cells by using the lipofectamine, and the empty vector pcDNA3 to transfect GES-1 cells as controls. And then, the cells were cultured in 1640 culture medium containing an appropriate concentration of G418 for selection. The method of HRP label immunohistochemical staining was used to identify the cells expressing bcl-2 gene positively. The morphologic changes of GES-1 cells were observed under an optical microscope by HE staining. The cell proliferation affected by the transfection of bcl-2 was measured by cell counting and MTT assay. RESULTS: bcl-2 gene and the vector pcDNA3 were transfected separately into GES-1 cells by lipofectamine. After G418 selection, the cells were transfected steadily. Compared with controls, HRP label immunohistochemical staining showed that bcl-2 gene transfected cells expressed Bcl-2 protein much more obviously. No morphologic changes were observed by HE staining. The growth curve was drawn by the method of cell counting,which showed that the growth of bcl-2 gene transfected cells was faster than that of empty vector transfected cells and untransfected cells after 6 d culture. And MTT assay showed that the growth of bcl-2 gene transfected cells were 4.15±0.31,5.98±0.56 and 8.94±0.79, respectively. While MTT assay showed that the growth of control cells were 3.01± 0.20 , 4.76±0.52 and 7.69±0.84, respectively. Significant differences were found between the 2 groups (P 0.05). CONCLUSION: The transfected of bcl-2 gene makes the cells express Bcl-2 protein steadily and highly, and enhances the cells' proliferation and malignancy.


The article considers the phenomenon of binding two independent sentences. Means of linking the mononuclear nominal sentence with the basic phrase are analyzed and classified. The research confirmed that binding of independent sentences is implemented through functioning of schemes which include the specified elements – articles and adjectives. The research is illustrated by examples from modern French prose.


Internal Control is one of the important things in company management, particularly to improve sales effectiveness. The goal of this research is to know how internal control in the company works and whether effort done by the company management can improve sale effectiveness.

This research was done at PT AGRICON PUTRA CITRA OPTIMA TERMINIX, the company operates in service sector of pest exterminator by means of fumigation, termite baiting system (TBS), and chemical barrier system (CBS). The company is located in Bogor.

This under-thesis arrangement has purposes for the author as well, namely to enlarge knowledge and to extend insight, especially about internal control system. In collecting data needed, the author did literature study related to the issues discussed. Besides, she carried out field study directly to the company that would be observed and examined.

The results of this research shows that PT AGRICON PUTRA CITRA OPTIMA TERMINIX has worked well with internal control system. There has been separation of duties and functions of sale; and transaction process has been running well. In addition, the company has run internal control by questionnaire, narrative, and flowchart well; and it almost meet five components of internal control system in accordance with COSO. The selling system is arranged well and there are evidences to sale effectiveness.


This literature review provides an overview of existing research and compares, and contrasts aims and definitions of Inclusive Education (IE) policies in China and Australia. It begins with the development of IE in each country; then it describes definition and concept of IE. The last section summarizes research in early childhood education in both countries.


The response of dams subjected to seismic excitation can be evaluated by a number of analysis methods. The traditional approach is to employ linear static or dynamic analyses coupled with appropriate modification to account for inelastic response while current design practice is moving towards an increased emphasis on nonlinear static analysis methods. In this study, a seismic response analysis of a double- curvature arch dam has been performed using nonlinear static analysis similar to capacity spectrum method. The method involves choosing the proper coordinate to evaluate the structure's behaviour using a suitable push load profile, conversion of seismic demand to the same coordinate, and determination of the performance state. The results of the developed algorithm have been compared with time history dynamic analysis of Karoun IV double curved arch dam which shows reasonable agreement with considerable less expenses and complications.


Generation of narrow microwave signals produced from the mode beating of a DBR laser is presented. The application of this process to the cw-THz wave generation is also demonstrated using a slotted FP laser.


Thank you very much for reading islam modernity transformation of an intellectual tradition. As you may know, people have look hundreds times for their chosen readings like this islam modernity transformation of an intellectual tradition, but end up in infectious downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they cope with some infectious virus inside their desktop computer.


The purpose of this thesis is to investigate how the support and readiness will be affected in a manufacturing company, in this case Scania, during the phase out period of a platform. The first two ...


Mathematical language, which embodies visuals and abstract concepts such as symbols, shapes, contains differences for visually impaired individuals. Using various writing codes that make these differences and reading by touch is the source of mathematical communication for visually impaired individuals. Mathematical language does not have a common framework in Braille, which differs according to countries and institutions. Therefore, there is no standard in mathematical language for Braille in Turkey. This situation is reflected in the mathematical communication of visually impaired students. In this study, it is examined the role of Braille in mathematical communication. The participants of the study which was designed in a multi-case study design were six visually impaired individuals determined according to the criteria and stratified sampling method. The texts, tables and graphics that the participants frequently use in classrooms were used in the clinical interviews on their experiences in mathematics learning and their reflections on some algebraic concepts. When the findings obtained by content analysis were examined, it was found that Braille caused difficulties in mathematical language usage and played an important role in the use of symbols and shapes. In addition, it has been determined that embossed writing should be adapted in a way to enable communication with visually impaired individuals in the educational practices and in consideration of mathematical language requirements.


A research on the structure and composition of mangrove vegetation in the Bangkagi Village South Walea Tojo Una Una District has been conducted from September to October 2013 which aims to determine the structure and composition of mangrove vegetationin the studied area. The research was used exploratory survey method by using line (transect method) and in thetransects, plots were made in the size 10 m x 10 m for the observation of trees,5 m x 5 m for the poles and the 2 m x2 m for seedlings.The result of the research showed that there were 7 species of mangrove namely: Ceriopstagal, Avicennia marina, Sonneratia alba, Rhizophora mucronata, Bruguiera gymnorhia, Xylocarpus molluccensis and Schiphyphora hydrophillacea . It's belong to 5 family that Rhizophoraceae, Avicenniaceae, Sonneratiaceae, Meliaceae and Rubiaceae. The diversity index of Mangrove species at Bangkagi village was low. Species Mangrove of trees in the studied area were dominated by Rhizophora mucronata (193,63%),mean while Rhizophora mucronata (173,30 %) and Rhizophora mucronata were dominant on the level of sapling and seedling (135,35 %). Keywords :Structure, Composition, Mangrove, Bangkagi village.


This paper investigates pragmatic acts in the discourse of tweeters and online feedback comments on the activities of Boko Haram, a terrorist group in Nigeria. The tweets and comments illustrate acts used to express revolutionary feelings and reflect what people say and imply in times of crisis. Tweets about Boko Haram are speech and pragmatic acts that denounce the Nigerian government, reject Western education, and call for support. Tweets and reactions from non-Muslims and nonradical Muslims condemn terrorism and denounce the terrorist group. While some tweets simply offer suggestions on how to curtail the Boko Haram insurgency, others seek the breakup of Nigeria, granting political and religious independence to the north and the southeast of the country.


Th an ks to an ag re em en t m ad e wi th th e Na tio nal Association for the Deaf (NAD) back in 2012 (which was brought about by a lawsuit), the hearing impaired have access to subtitles across Netflixs catalog of content. However, the visually impaired havent received the same attention from the streaming service. While descriptive audio tracks are increasingly common in movie theaters and on Blu-ray discs, they have remained absent from Netflix contentuntil now. In a recent announcement, Netflix says it will be adding audio descriptions to select titles, and Marvels new Daredevil series is the first to get it. Now, visually impaired subscribers can enjoy the original series with a narration track that describes everything happening on screen, from physical actions, to facial expressions, costumes, settings, and scene changes. Anyone knows that especially with superhero flicks, the visuals are a large part of the experience. So this is a major move, not to mention a great first


Electrochemical noise(EN) test of aluminum alloys LC4, LY12 and pure aluminum in 2.0%(mass fraction) NaCl solution(pH=7.01) was reported. The potential fluctuation of the electrodes was recorded in time domain and simultaneously processed by fast Fourier transform method to gain spectra power dendsity(SPD) curves in frequency domain. It is found that EN characteristic varies with materials, that is, in time domain, pure aluminum and LC4 can stochastically exhibit sudden potential drop, which results in a sharp peak in potential-time curves, but LY12 does not. And the three features in SPD curve: W(white noise level), fc(cutoff frequency), and K(the slope of the high frequency domain), all change with the corrosion process and reach their extremum when pitting occurs. Any single parameter cannot correctly predict the strength and trend of pitting. However, two parameters SE and SG derived from the SPD curves can correctly predict whether pitting has occurred or not. That is, for different materials, pitting corrosion usually occurs when SE 5 and SG 1.


One of the greatest challenges facing the global financial and banking system is the lack of adequate supervisory and regulatory controls. This has been evident in the dismissal collapse of the global financial system resulting in the general economic downturn currently being experienced. This paper explores the possibility of using established fiqh principles in articulating a proactive legal regime for controlling the operations of Islamic banks. In particular, the paper examines the extent to which these principles will co-exist with the conventional regulatory banking processes given the religious diversity and federal nature of Nigeria's constitution. This is especially an important consideration because of the absence of a defined Islamic regulatory outfit for banking business in Nigeria. Furthermore, the paper also explores the extent to which the fiqh regulatory model of prudential supervision of banks will provide both a legal, as well as, an ethical blue-print for corporate banking governance. The paper concludes by advancing the ways forward, especially in the context of evolving a dual (fiqh and conventional) regulatory and supervisory control systems for banks (Islamic) in Nigeria.


The fast maneuverability of radar is the crucial to win the battle on a field. This article, mainly presents the aims and methods to realize the high maneuverability of radar, and deseribes the idea of designing the antenna vehicle in terms of its construction, transmission and control.


Abstract Background: The pathogenesis of recurrence of traumatic benign paroxysmal positional vertigo (BPPV) is poorly understood by far. Objectives: To evaluate the value of secondary otolith dysfunction using vestibular evoked myogenic potential (VEMP) test in the pathogenesis of recurrence of BPPV after mild traumatic brain injury (mTBI). Material and methods: We reviewed 42 patients with BPPV after mTBI. According to recurrence, patients were divided into two groups. Both cervical VEMP (cVEMP) and ocular VEMP (oVEMP) tests were performed on all of them. Results: We detected abnormal cVEMP responses in four (26.7%) patients in the recurrent BPPV group after mTBI and five (18.5%) patients in the non-recurrent BPPV group after mTBI, and there was no significant difference between both groups. We detected abnormal oVMEP responses in nine (60.0%) patients in the recurrent BPPV group after mTBI and six (22.2%) patients in the non-recurrent BPPV group after mTBI, and there was a significant difference between both groups. Conclusions and significance: Our study shows that oVEMP abnormalities in recurrent BPPV group after mTBI are significantly higher than those in non-recurrent BPPV group after mTBI. Therefore, we can conclude that secondary utricular dysfunction may be a potential pathogenesis of recurrence of traumatic BPPV.


Circumcision remains the most controversial surgery in human history and the foreskin undoubtedly "pound for pound" the most contentious body part. Not inasmuch due to any complexity with regards to the surgical procedure itself or elaborate function of the prepuce, but more with regards to the controversy, emotion, discussion, discourse, bickering, fundamentalism and partisanship these subjects stir. Neonatal routine/ritual/nontherapeutic circumcision is also one of the only topics which generates very conflicting outcomes and representations in the peer reviewed medical literature, allowing proponents and opponents to "cherry pick" studies, meta-analyses or parts hereof in support of their own view and agenda. Hence it has always been our practice to read, analyse and interpret the results of any such study with a "pinch of salt" and a fair amount of healthy skepticism. One of the documented and established facts however, is that the circumcised status decreases the risk of urinary tract infection especially in infancy. This in turn begs the question of whether this reduction in UTI risk is clinically significant and if so, if it outweighs the risk of harm which potentially befalls the non-consented patient. In the current chapter by Morris and Krieger the balance tips unreservedly in favour of circumcision especially when performed early in life, with the authors even equating circumcision with vaccination, and almost berating the decision not circumcise, and putting it on par with a decision not to vaccinate a child. Statements that are quite stinging in these "anti-vaxer" times.


INTRODUCTION: Postpartum pelvic floor dysfunction (PFD) is associated with reduced quality of life; however, patient education regarding PFD is limited. The purpose of this study was to evaluate impact of PFD education and pelvic floor physical therapy (PFPT) referral on patient satisfaction with postpartum care. METHODS: This randomized controlled trial included 160 postpartum patients recruited during their delivery admission between November 2020 and June 2021. Patients were randomized to receive postpartum PFD education materials and PFPT referral (n=80) or to receive standard postpartum teaching (n=80). The Client Satisfaction Questionnaire (CSQ-8) was used to assess patient satisfaction at 12 weeks postpartum. RESULTS: In total, 131 (81.87%) participants completed the questionnaire. The groups were well matched in terms of demographics, comorbidities, and delivery type. In total, 60 of 131 (45.8%) reported PFD symptoms. Overall satisfaction did not differ between groups (27.43 vs. 28.31 out of 32, P=.28). Significantly more patients in the intervention group felt that they received enough PFD education and support (47.1% vs. 27.0%, P=.017). Of those who read the educational materials (48 of 68, 70.6%), 89.6% found them helpful, and 100% thought all patients should receive PFD education. Most common obstacles to attending PFPT included lack of interest, time commitment, and childcare. CONCLUSION: Our study demonstrates that while providing PFD education and PFPT referral does not lead to increased patient satisfaction, patients do find these resources helpful. Postpartum PFD is prevalent; however, few patients attend PFPT despite referrals. We identify specific barriers to attending PFPT which are targets for future studies on patient satisfaction.


The introduction of cloud computing techniques revolutionized the current of information processing and storing. Cloud computing as a competitive edge provides easy and automated access to the vast ocean of resources through standard network mechanisms to businesses and organizations. Due to the vast diversity of service providers and their respective variety of available services with different qualities, top managements often face difficulty for choosing the best available option. So, considering the growing significance of the mentioned issue, this study aims to identify and rank contributing factors in selection of cloud service providers. In that attempt, this research approaches its goal by going through three major phases. Firstly, in phase one, prior studies are reviewed for extracting related elements of selection. Secondly, by employing Fuzzy Delphi method and obtaining results by interviewing experts in this field such as IT managers and technicians, this study tries to finalize the list of contributing factors. Lastly, by utilizing Fuzzy best-worst multi-criteria decision-making method, which is one of the most recent techniques employed to statistically rank variables, this research introduces a list of vital factors for cloud service selection. Based on the findings of this study, there are five major categories involved in the selection process which are: performance, security, data management, personal data protection and environmental-organizational. The finalized result of ranking shows that, performance related factors such as accessibility, response time and capacity are the first priority. The runner-up is security with reliability and governance. Environmental-organizational variables lands in the third place by considering rental and network costs.


Aeroacoustic simulations are extremely sensitive to numerical errors. To achieve a highorder of accuracy, optimized finite difference schemes, such as the well-known dispersionrelation-preservation schemes, and multi-block structured meshes are often used. Challenges appear in communicating the flow information between neighboring blocks, and sophisticated interface treatments are required. The characteristic interface condition has shown to be successful in applications in previous publications, and yet limitations exist that are identified in the present study. This paper proposes a new interface treatment based on a unified finite difference and finite volume discretization. Applications to several benchmark cases show an encouraging improvement as compared to the characteristic interface treatments.


Regular load generation imbalances aka power system small disturbances in a network is always a matter of great concern which lead a major task of stability improvement to the technicians. Moreover when in place of single area network, there comes multi-area multi-machine power system, the overall dynamics becomes very integrated and complex to analyze. To suppress the oscillations of the system state variables i.e. to keep their deviation within some limit for a long period during small disturbances caused by load swinging or others , small signal analysis is needed first in place. Till date extensive researches has been done developing many toolboxes to analyze small signal stability like PSAT, SSST, PST, PAT, PSS/E, DigSILENT, EUROSTAG, SimPow and others. Among all PSAT is the most recommended and used software for the purpose. In this work a new algorithm has been developed to analyze the classical two-area four- machine system which is compared with PSAT's ( Power system analysis toolbox) result and literature's result. It came out that there's a significant amount of inaccuracy in PSAT's outcome and inter-area oscillation mode is found to be the most critical zone for analysis rather than local modes of oscillations in power system network.


Abstract An ideal of "home" as the best site for living and dying in old age has become embedded in residential care policies and practices in many countries, often in tandem with neoliberal restructuring. This article compares the ways that two Canadian jurisdictions have approached this ideal, and identifies contradictions in the effects this policy direction has had for direct care workers and residents. The investigation reveals challenges and possibilities for gender equity.


Objective To observe the effects of preoperative acute hypervolemic hemodilution (AHH) on coagulation and fibrinolysis on the elderly patients undergoing hepatic carcinectomy.Methods Thirty ASA Ⅰ~Ⅱ liver cancer patients over sixty years old undergoing scheduled elective hepatic carcinectomy were random divided into AHH group ( n = 15) and control group ( n = 15).AHH was performed by infusing 15 ~20ml/kg 6% Voluven ( 130/0.4) in a rate of 30ml/min on patients in AHH group,and the patients in control group were infused routinely lactated Ringer's solution.Blood samples were collected for measuring coagulation function and platelet activation before anesthesia (T1) ,30 minutes after AHH (T2),1 hour ( T3 ), immediately (T4) and 24 hours (T5) after operation in group AHH, and the similar procure was used in control group.Results There was significant difference in the volume of allergenic blood transfusions between the two groups(20% vs 53.3%, P <0.05).PT and APTT in both groups prolonged significantly after T2, but they all remained in normal range.TT and DD had no significant changes between the two groups.SFMC and F1 + 2 increased in both groups, but it had no significant changes.PAC-1 and CD62P expressions of group AHH were significantly lower T2, T3 ,respectively ( 1.37 ±0.4) %, (1.28 ±0.4) %, than those at T1 [( 1.96 ± 0.6) %] ( P < 0.05 ).Compared with control group, CD62P was significantly lower in AHH group at T2 and T5.Conclusion It is safe to take AHH of Hct 25% to 30% during hepatic carcinectomy for elderly liver cancer patients without cardiac and pulmonary disease.And it could decrease allergenic blood transfusions, with no apparently influence on coagulation function.

Key words:
Hemodilution;  Hepatectomy;  Fibrin fibrinogen degradation products/ME;  Prothrombin/ME;  Platelet activation;  Intraoperative period


The present study reports numerical analysis of turbulent jets. This study investigates the effect of initial jet velocity on the location of the merging and combining points of two dimensional co-flowing turbulent jets. Flow geometry under consideration is three co-flowing rectangular jets. Effects of inner jet and outer jets exit velocities are investigated. Numerical results are obtained with a finite volume CFD code. Turbulence is treated with a two equation k-e model. Different jet velocities have been examined corresponding to Reynolds numbers of 2,000 to 35,000. Structured grids are used in the present study. Results show that the initial velocity of the inner jet has significant effect on the merging and combining points.Copyright © 2007 by ASME


textabstractInfluenza A virus, together with Influenza B virus, Influenza C virus, Isavirus
and Thogotovirus, are the five genera forming the family Orthomyxoviridae.
Orthomyxoviridae are enveloped, negative-stranded RNA viruses with a segmented
genome. Influenza A viruses can be further categorized into subtypes based on two
surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA). To date,
16 different HAs and 9 different NAs have been found and may occur in virtually all
possible combinations. Free-ranging waterbirds are considered to be the natural
reservoir of all influenza A viruses. Even though some mammalian species—
humans, pigs, horses and dogs—harbor their own influenza A viruses, there is strong
evidence that these mammalian viruses originate from avian influenza A viruses. In
addition, avian influenza A viruses may cross the species barrier to other mammals
without developing into a stable lineage in the new host species. An example is
the outbreak of avian influenza virus of the subtype H7N7 in harbor seals in 1979.
Interestingly, the primary replication site for influenza A virus differs between birds
and mammals. In birds, the virus replicates primarily in the intestinal tract, whereas
in mammals, it replicates primarily in the respiratory tract.
An important feature of avian influenza viruses is their capacity to mutate into forms
that cause high mortality in poultry. Such mutations only have been recorded for the
subtypes H5 and H7 and occur after transmission of these viruses to poultry. Based
on their capacity to cause morbidity and mortality in chickens, avian influenza viruses
are classified as low pathogenic avian influenza virus (LPAIV) or high pathogenic
avian influenza virus (HPAIV).


Modern features of Java software platform allow developers to create a new generation of application configuration frameworks with advanced features, such as type-safety, easy extendability and self-documentation. This paper describes an early prototype implementation of such a framework, currently under development as an open-source project.


This paper explores the challenges and learning achieved in utilising co-operative inquiry groups as an action research method through the presentation and critical reflection of two different research projects located in health and social care settings. One study was based in a domestic violence agency and the other was based in an age-related healthcare multidisciplinary team in an acute hospital. The paper compares and contrasts the use of a co-operative inquiry approach in these different contexts and explores how the action-based approach affected the way in which practitioners shaped, developed and implemented improved responses and work practices. The paper offers a vivid insight into the complexities of establishing, maintaining and negotiating research relationships where there are inherent power differentials and reveals the strong parallels that can be drawn between research and professional relationships. Learning points fell into three broad areas: participation and engagement within the inquiry group process, power and decision-making and the influence of organisational structures on practice and policy changes. A significant strength of this paper is the reflexive and inquiring conversations which took place between the researchers which facilitated a critical reflection of shared experiences, dilemmas and action learning from utilising a co-operative inquiry group approach.


A new two-dimensional Newton's method Navier-Stokes solver is extended to the axisymmetric form of the equations. Roe's flux difference splitting is applied to the axisymmetric equations using Glaister's approach. A geometric conservation law correction term is added to insure satisfaction of the uniform stream reproduction criteria. Higher-order accuracy is attained through the use of Spekreijse's interpolation procedure with Van Albada's contiouous limiter. Harten and Hyman's minimum eigenvalue correction is also included


The encryption anti-counterfeit method for RF electron label data, it reads UID incrimination code in ROM of radio frequency electron label, new data come into being through logic operation, and it is written in erasable memory. The UID code is only and unchangeable, the coding data is written in erasable memory of label through logic coding operation, the erasable memory and unchangeable UID hasa conventional logic relation. Althrough the illegal users can read and write coding data, they can't change the UID code of label.


Spherical zinc gallate phosphors were prepared by using aerosol pyrolysis method. The synthetic parameters such as post heat‐treatment temperature, activator concentration, and degree of reduction were optimized for the maximum CL intensity. For enhancing the CL luminous efficiency of phosphors, adjustments of lattice structure were also considered. It was sensitive to the crystal structure in host lattice, which would be engineered by Al‐concentration in ZnGa‐Al‐O system. Zinc alumino gallates particles with spherical shape showed the brightness of 550cd/m2 with color coordinate of x=0.1665 and y=0.6655 under an excitation of 400V, 50μ/cm2.


Wear behaviors of two U71Mn K and U71Mn G rail steels have been systematically investigated with the simulated experiments during the tolling contact fatigue using samples taken from their base materials, the heat-affected zones near the weld, and the weld zones, respectively. The results demonstrate that there are significant differences between the nonweld and the weld zones for both steels. With higher hardness of U71Mn G over U71Mn K, the U71Mn G steel has mild abrasion damage, reduced weight loss from wear and reduced corrugations of the weld zone during the experiment with increased simulative speed; while its other features such as the plastic deformation and cracks are almost the same compared with the U71Mn K steel. The U71Mn G steel demonstrates superior performance over U71Mn K at the high-speed rolling experiment.


Anal carcinoma is treated primarily by chemoradiation. Failure of this treatment requires salvage surgery. The aims of this retrospective study were to assess the survival probability after rescue surgery and design a pathological risk score (PRS) to predict postoperative outcome.


Background: A high prevalence of adolescent girls experience ovulatory-menstrual (OM) health difficulties such as painful periods, premenstrual symptoms, irregular cycles and abnormal bleeding patterns. These difficulties are associated with school absenteeism and reduced concentration in class. In addition, there is also an association with mental health challenges such as a negative body image, the onset of eating disorders and non-suicidal self-injury. A review of school-based resources suggests that this stigmatized subject is not only couched in biology, but it can be presented negatively. Aim: This research project aimed to develop and trial a school-based OM health literacy program that positively addresses the biopsychosocial aspects of the OM cycle. Method: A Delphi Panel was convened with experts in medicine, education, and public health. Together with a systematic literature review of OM health programs, they informed a draft program to teach adolescent girls and a draft questionnaire to test their OM health literacy. These drafts were reviewed by adolescent girls, parents, teachers and school healthcare professionals in focus groups and one-on-one interviews. The draft questionnaire was then test-retested to establish its validity. Results: The Delphi Panel validated the content of the draft program. Based on the principles of Positive Education, the program was mapped to the Western Australian curriculum, Nutbeam's Health Literacy Model and the WHO's Health Promoting School framework. The focus groups and one-one-one interviews face validated the program and questionnaire, and suggested additional refinements (e.g. website, animations, videos, and the name My Vital Cycles™). Conclusion: My Vital Cycles™ recognizes the OM cycle as a biopsychosocial phenomenon. It practically addresses common OM health difficulties with the aim of improving OM health literacy using Positive Education principles. The program has been registered for clinical trial.


Despite the major progress obtained in prognosis with the use of tyrosine kinase inhibitors (TKI), the great majority of patients with CML remain on long-term therapy and progression occurs in patients with either primary or secondary resistance. The mechanisms of progression towards accelerated phase (AP) and blast crisis (BC) have been studied so far only in primary patient samples in BC. Currently, there is no in vitro model to study sequentially the molecular events leading from CP to BC as only some primary sequential samples are amenable to analysis. Using induced Pluripotent Stem Cell (iPSC) technology, it is now possible to reprogram the primary leukemic cells to pluripotency and generate a major source of stem cells. To determine the feasibility of studying progression of CML towards AP and BC, we have used a patient-specific iPSC line that we have generated from the primary leukemic cells of a patient who later showed a TKI-resistance requiring an allogeneic stem cell transplant. These iPSC expressed BCR-ABL, exhibited all pluripotency markers and after injection in NSG mice, generated teratoma with differentiation into three germ layers. In hematopoietic differentiation assays using day 19-embryoid bodies (EB), increased numbers of hematopoietic progenitors were found as compared to control iPSC (5-fold increase n= 3). We have then treated leukemic iPSC with the mutagenic agent N-ethyl-N-nitrosourea (ENU) during regular medium changes. After 61 days in ENU cultures, day-19 derived embryoid bodies generated hematopoietic cells (>90% CD45+, CD43+) which proliferated in liquid cultures with myeloid and some blast cell morphology. Cytogenetic analyses of iPSC revealed chromosomal abnormalities such as loss of Y and loss of der q9+, both alterations known to occur in CML during progression. They exhibited increased numbers of micronuclei (MN) as compared to leukemic iPSC without ENU (X 3 Fold increase) suggesting acquisition of a progressive chromosomal instability. CGH array analyses were performed using ENU-treated iPSC-derived hematopoietic cells in two different timepoints as compared to leukemic iPSC cultured without ENU. Genomic aberrations were analyzed by Agilent Cytogenomics software with Mosaicism workflow on HG19 genome. 249 gene loci alterations were detected after polymorphism filtration on European population. These analyses showed DNA losses and DNA gains in genes implicated in mesoderm development and hematopoietic lineage as well as genes implicated in DNA damage response. Several loci of transcription factors were found to be involved such as IKZF1 described in imatinib-refractory chronic myeloid leukemia (Bolton-Gillespie et al. 2013). The aberrations included SIRT1and BLM which is implicated in DNA repair. Several cancer genes were found to be involved, some known to be altered in leukemia (BLM, IKZF1, NCOA2, ALK, EP300, ERG, MKL1, PHF6 and TET1). Remarkably, transcriptome geodataset GSE4170 (Radich et al. 2006) allowed us to associate 125 of 249 of the aberrations that we detected in CML iPSC, with the CML progression genes already described during progression from chronic and AP to BC (p-value =9.43E-32, after ANOVA with 1000 permutations). 38 most predictive aberrations allowed perfect reclassification of BC and chronic phase samples by unsupervised classification. Among these candidates, eleven of them have been described in CML physiopathology and connected to TKI resistance and genomic instability. Majority of them ( 7/11) are connected to chronic phase (FAS, ACTB, TRIM21, ANPEP, MLK1, CSF2RA, and MAGEC2) whereas a minority of them (4/11) are connected to BC (ACP1, SH3YL1, FHL1, IL3RA). Interestingly, these experiments also allowed us to discover the connection of a new multidrug resistance molecule associated to BC and having the ability to modify interferon pathway connected to the TKI sensitivity. Thus, genomic instability pattern that we have generated using a single leukemic iPSC allowed duplication of genomic abnormalities described in CML progression and allowed identification of some novel genes. Overall, these results demonstrated that we have generated for the first time to our knowledge, an in vitro BC model, reproducing genomic events described in patients with BC. This "blast crisis in a dish" tool using patient-derived iPSC will be of major interest to study CML progression and eventually to test novel therapies. Disclosures No relevant conflicts of interest to declare.


This study applied a social representations approach to investigate the ways in which constructions of perceived political disagreement and the prevailing opinion climate were implicated in people's construals of political participation in the context of the United Kingdom European Union referendum of 2016. Interviews were conducted with 19 residents of the United Kingdom who voted to remain in the referendum, located in constituencies which represented diverse opinion climates in relation to the referendum. Thematic analysis of the data revealed that public opinion was a dilemmatic social representation; it was inscrutable and often ill‐informed but also volatile and disruptive, which left open the possibility of it moving towards a more pro‐EU position. Importantly, constructions of a polarized and dysfunctional political system worked to sustain a mode of political engagement which prioritized and positioned as efficacious individual rather than collective anti‐Brexit political behavior. This implies that people may prefer different types of political participation depending on the opinion climate which they occupy and the way in which they construe it. Findings are discussed in relation to previous work linking meta‐representations to political behavior and expression, and the implications of the findings for emergent forms such as Brexit are elaborated.


A connector as disclosed for connecting fluid passages through a flexible sheet material. The connector is appropriate for use in connecting the coolant lines of a personal cooling garment through a waterproof immersion suit or a chemical proof outer garment. The connector includes inside and outside connector blocks with matching faces that sandwich the sheet material between them. Fluid passages through the two blocks meet at respective ports in the matching faces and are joined by coupling sleeves extending through holes in the sheet material. O-rings around the ports seal the holes through the sheet material. A cap screw or the like secures the two blocks to one another. The connector is equipped with valve male fittings and male lock components of a standard connector system that is now used for personal cooling garments. This allows the use of the connector in conjunction with an existing and satisfactory "zero leak" connect and disconnect system.


List of Figures and Tables. Foreward. Preface. 1. A Visit to the Tsachilas. 2. The Western Pichincha Project. 3. The Ethnohistory of Western Pichincha. 4. Looking for Sites in All the Right Places. 5. How to "X-ray" a Deeply Buried Cloud Forest Site. 6. Performing "Exploratory Surgery" at Nambillo. 7. Lost and Found - Special Interest Sites. 8. Reading the Artifacts. 9. Yumbos, Niguas and the Space-Time Continuum. 10. What We"ve Learned, or Who Said Hindsight is 20-20? References. Credits. Index.


Abstract : Terrorism is not a new phenomenon in international relations, but the nature of the threat is taking on frightening new dimensions in an era of weapons of mass destruction and global access. The diversification of potential terrorists ranging from political groups to religious fanatics to individuals motivated solely by political revenge, further complicates government policy-making to deter terrorist actions. The number of incidents of international terrorism, defined as remediated, politically motivated violence perpetrated against noncombatant targets by sub-national groups or clandestine agents, usually intended to influence an audience" has declined since the 197Os but the death toll has risen. As governments have demonstrated more skill at handling hijacking and hostage crises, terrorists have adjusted their tactics to more lethal bombings. Asymmetric attacks against the US are more likely in this era of our sole superpower status where most opponents recognize our dominance in conventional warfare. These trends bode ill for the possibility of terrorists moving up the scale to the threat or use of nuclear/biological/chemical (NBC) weapons for even greater impact on societies and experiments.


BACKGROUND: Mucosal healing is considered an important benefit of treatment with anti-tumor necrosis factor alpha for Crohn's disease (CD). However, the details of mucosal healing in Japanese patients with CD treated with infliximab or adalimumab remain unclear. We analyzed the mucosal healing rate and its related prognostic factors in Japanese patients with CD treated with infliximab. METHODS: We investigated patients who were treated with infliximab for CD between January 2003 and November 2010 at the IBD Center, Sapporo Kosei General Hospital. The inclusion criteria were as follows: 1) patients who received infliximab for at least 6 months; 2) those who underwent baseline ileocolonoscopy and who had mucosal ulcerations in the terminal ileum, cecum, colon and/or rectum; and 3) those with baseline mucosal ulceration and who underwent follow-up ileocolonoscopy 7–30 months prior to receiving dose intensification of infliximab. Mucosal healing was defined as absence of mucosal ulceration at baseline. Univariate analysis was performed to determine clinical predictors associated with mucosal healing in patients with CD who received infliximab. RESULTS: A total of 56 patients were selected for this retrospective study. Of these, 17 were female. The mean patient age was 27.3 ± 9.6 years, and mean disease duration was 4.4 ± 5.7 years. Thirty-five patients had ileocolitis, 12 had ileitis, and 7 had colitis. Concomitant treatment with azathioprine or 6-mercaptopurine (immunomodulators), 5-aminosalicylic acid (5-ASA), elemental diet therapy, and prednisolone was administered in 41, 45, 41 and 46 patients, respectively. Seven patients underwent surgery for CD. Mucosal healing was observed in 77.8% patients. Concomitant treatment with immunomodulators and 5-ASA was a significant predictor of mucosal healing, whereas surgical intervention was a significantly poor predictor. CONCLUSIONS: Satisfactory mucosal healing rate was achieved in patients with CD who did not require dose intensification of infliximab. It may be important to administer immunomodulators and 5-ASA concomitantly and to initiate treatment with infliximab prior to surgery to achieve a high mucosal healing rate with infliximab in Japanese patients with CD.


The Upper Ordovician in the Tarim Basin contains 5000–7000 m of siliciclastic and calciclastic deep‐water, gravity‐flow deposits. Their depositional architecture and palaeogeographical setting are documented in this investigation based on an integrated analysis of seismic, borehole and outcrop data. Six gravity‐flow depositional–palaeogeomorphological elements have been identified as follows: submarine canyon or deeply incised channels, broad and shallow erosional channels, erosional–depositional channel and levee–overbank complexes, frontal splays‐lobes and nonchannelized sheets, calciclastic lower slope fans and channel lobes or sheets, and debris‐flow complexes. Gravity‐flow deposits of the Sangtamu and Tierekeawati formations comprise a regional transgressive‐regressive megacycle, which can be further classified into six sequences bounded by unconformities and their correlative conformities. A series of incised valleys or canyons and erosional–depositional channels are identifiable along the major sequence boundaries which might have been formed as the result of global sea‐level falls. The depositional architecture of sequences varies from the upper slope to abyssal basin plain. Palaeogeographical patterns and distribution of the gravity‐flow deposits in the basin can be related to the change in tectonic setting from a passive continental margin in the Cambrian and Early to Middle Ordovician to a retroarc foreland setting in the Late Ordovician. More than 3000 m of siliciclastic submarine‐fan deposits accumulated in south‐eastern Tangguzibasi and north‐eastern Manjiaer depressions. Sedimentary units thin onto intrabasinal palaeotopographical highs of forebulge origin and thicken into backbulge depocentres. Sediments were sourced predominantly from arc terranes in the south‐east and the north‐east. Slide and mass‐transport complexes and a series of debris‐flow and turbidite deposits developed along the toes of unstable slopes on the margins of the deep‐water basins. Turbidite sandstones of channel‐fill and frontal‐splay origin and turbidite lobes comprise potential stratigraphic hydrocarbon reservoirs in the basin.


In this work, we will present a novel graphene synthesis technique, based on the ion implantation of carbon ions into polycrystalline transition metal thin films. Ion implantation is now a routine process developed by the semiconductor industry over the past three decades. It is used to dope the source and drain contact regions as well as to adjust the channel characteristics of CMOS transistors. One of the advantages of ion implantation is that it allows one to precisely control the carbon dose introduced in a particular substrate.


Nitrates pollution of waters is a worldwide problem and its remediation is a big challenge from the technical and the scientific point of view. One of the most used and promising cleaning techniques is the biological treatment of wastewaters operated by bacteria. A freshwater microalgae Chlorella sp. was investigated for its ability to remove both nitrogen and phosphorus from influent. Amount of wastewater containing nitrogen is increasing in the environment due to industrialization.  It is necessary to remove nitrogen from waste as it causes eutrophication. The study was carried out to increase characteristics, efficiency and economy of wastewater by the low-cost microorganism.


Abstract The CO2 and N2O soil emissions at a rice paddy in Mase, Japan, were measured by enclosures during a fallow winter season. The Mase site, one of the AsiaFlux Network sites in Japan, has been monitored for moisture, heat, and CO2 fluxes since August 1999. The paddy soil was found to be a source of both CO2 and N2O flux from this experiment. The CO2 and N2O fluxes ranged from -27.6 to 160.4μg CO2/m2/sec (average of 49.1 ± 42.7 μg CO2/m2/sec) and from -4.4 to 129.5 ng N2O/m2/sec (average of 40.3 ± 35.6 ng N2O/m2/sec), respectively. A bimodal trend, which has a sub-peak in the morning around 10:00 a.m. and a primary peak between 2:00 and 3:00 p.m., was observed. Gas fluxes increased with soil temperature, but this temperature dependency seemed to occur only on the calm days. Average CO2 and N2O fluxes were 27.7 μg CO2/m2/sec and 13.4 ng N2O/m2/sec, with relatively small fluctuation during windy days, while averages of 69.3 μg CO2/m2/sec and 65.8 ng N2O/m2/sec were measured during calm days. This relationship was thought to be a result of strong surface winds, which enhance gas exchange between the soil surface and the atmosphere, thus reducing the gas emissions from soil surfaces.


We report a flexible language-model-based deep learning strategy, applied here to solve complex forward and inverse problems in protein modeling, based on an attention neural network that integrates transformer and graph convolutional architectures in a causal multi-headed graph mechanism, to realize a generative pretrained model. The model is applied to predict the secondary structure content (per-residue level and overall content), protein solubility, and sequencing tasks. Further trained on inverse tasks, the model is rendered capable of designing proteins with these properties as target features. The model is formulated as a general framework, completely prompt-based, and can be adapted for a variety of downstream tasks. We find that adding additional tasks yields emergent synergies that the model exploits in improving overall performance, beyond what would be possible by training a model on each dataset alone. Case studies are presented to validate the method, yielding protein designs specifically focused on structural materials, but also exploring the applicability in the design of soluble, antimicrobial biomaterials. While our model is trained to ultimately perform eight distinct tasks, with available datasets, it can be extended to solve additional problems. In a broader sense, this study illustrates a form of multiscale modeling that relates a set of ultimate building blocks (here, byte-level utf8 characters that define the nature of the physical system at hand) to complex output. This materiomic scheme captures complex emergent relationships between universal building block and resulting properties, via a synergizing learning capacity, to express a set of potentialities embedded in the knowledge used in training via the interplay of universality and diversity.
 Significance statement: Predicting the properties of materials based on a flexible description of their structure, environment, or process, is a long-standing challenge in multiscale modeling. Our MaterioFormer language model, trained to solve forward and inverse tasks, incorporates a deep learning capacity through attention and graph strategies to yield a multimodal approach to model and design materials. Since our model is prompt-based and information is encoded consistently via byte-level utf8 tokenization, it can process diverse modalities of information, such as sequence data, description of tasks, and numbers, and offers a flexible workflow that integrates human intelligence and artificial intelligence. Autoregressive training, using pre-training against a large unlabeled dataset, allows for straightforward adjustment of specific objectives.


The article provides information about a stationary robotic stand designed for experimental research, a description of the operation of this stand is given. A feature of the stand is the implementation of a research facility with the possibility of programmatic research without the obligatory presence of a researcher. A remotely controlled power amplifier, a remotely controlled sound generator and a personal computer with special software are used. The sound source is located close to one of the end walls of the soundproof chamber. The sound receiver in the form of a high-precision microphone is located on the opposite end wall of the soundproof chamber and is connected to the sound processing module, which is connected to a personal computer. The developed stand is an example of the concept of robotic research, a direction for improving the methodology of research work. A description of the design of the stand is given; information about known similar research equipment is given. A scheme of the stand and a description of its design are given. Some results of studies of soundproof materials are given. The effect of the structure of soundproofing materials on the frequency characteristics of acoustic impedance is shown. The essence of test bench automation lies in programmatic change of research modes for each experiment. The robotic stand ensures the reliability of the results of experimental studies, allows you to speed up the results.


Objective To investigate the possible signal transduction pathways of rhythmic pressure maintained airway mucous secretion in airway epithelial cells.Methods Using gas/liquid interface to culture human airway epithelial 16HBE cells in vitro,two devices mimicked normal pressure wave which generated by the respiratory rhythm and affected the cultured cells.16HBE cells were divided into control group,rhythmic pressure,pressure and Ruthenium red,pressure and Verapamil,pressure and PKC inhibitors(GF109203x).The Ca2+concentration was observed by laser confocal,the level of TRPV_4 mRNA,the relative contents of pMARCKS and pSNAP-23,and the secretion of MUC(2,5AC and 5B) in culture medium were detected by RT-PCR,Western blot and ELISA respec-tively.Results Intracellular Ca2+ concentration(312.34±17.08) and TRPV_4 mRNA(0.63±0.03) level in the rhythmic pressure group were significantly higher than in the control group(P0.01),which decreased markedly after the intervention of RR(P0.01),meanwhile,there were obvious increases in the secretion of MUC(2,5AC and 5B),the relative contents of pMARCKS and pSNAP-23 protein.After the preprocessing of Verapamil and PKC specific inhibitors,either of MUC level,pMARCKS and pSNAP-23 protein reduced(P0.01).ConclusionsRhythmic pressure maintained the secretion of MUC in airway epithelial by activation of TRPV_4/Ca2+/PKC/MARCKS signal pathway.


A study was undertaken to investigate the effects of ground and foliar fertilizer applications on the growth of a 15-year-old Engelmann spruce (Piceaengelmannii Parry) plantation in the south central interior of British Columbia. The site had been broadcast burned prior to plantation establishment, and poor growth performance and pretreatment foliar analyses indicated that multiple nutrient deficiencies were likely growth limiting. Fertilization has had a very strong positive influence on height increment and branch elongation. Although growth responses were minimal in the 1st year after treatment, cumulative increases in height increment over the next 2 years averaged 41 cm (range 28–48 cm) greater than those recorded in unfertilized trees. In relative terms, these responses averaged 102% (range 90–120%). Improvements in branch increment over this 2-year period also averaged 102% (range 85–115%). Results indicate that the majority of the growth response has been due to improved nitrogen nutrition. Combin...


This is an edited collection of valuable and timely information concerning the care and conservation of human remains in museums and academic institutions. It contains a foreword by Brian Fagan.


Expressions for the effective nonlinear susceptibilities are derived for nanocomposites containing ellipsoidal nanoparticles and nanoshells. The intrinsic third- and fifth-order contributions are considered for the nanoinclusions. The field enhancement is determined for silver particles.


Productivity is one of the most critical of our nation's economic problems. [1][2] Productivity is very difficult to measure, but has been defined by economists very simply: "Basic output divided by basic input". Whatever we determine these "basics" to be in white collar work, in order to increase the output/input ratio we will need the following: reorganization and/or automation. Probably large amounts of both will be required.


This study aims to determine the provision of teacher reinforcement, student learning motivation and the influence of teacher reinforcement to student learning motivation. This research is an associative quantitative research that is to know the influence between variable X to variable Y. Location of research conducted at class X competence of expertise of Office Administration at VOCATIONAL SCHOOL YPLP PGRI 1 Makassar. The population in this research are 66 people, and the sample is 55 people like the respondent with the sampling technique that is Proportional Stratified Random Sampling. Data collection techniques used in this study are observation, questionnaires, and documentation. Data analysis techniques used were descriptive statistical analysis using percentage, mean and standard deviation and for inferential statistical analysis using data normality test, product moment correlation analysis, and simple linear regression analysis. The results of the research indicate that the reinforcement of teachers in VOCATIONAL SCHOOL YPLP PGRI Makassar is in a good category, regarding indicators: 1) verbal strengthening, 2) gestural reinforcement, 3) reinforcement activities, 4 reinforcement approach, 5) reinforcement touch, and 6) Sign reinforcement. For the motivation of studying class X students, the competence of the administrative skills of the Office Administration in VOCATIONAL SCHOOL YPLP PGRI 1 Makassar is categorized as high in terms of 1) the desire and the desire to succeed, 2) the encouragement and the need to learn, 3) the expectation and aspiration in The future, and 4) the existence of awards in learning, 5) the existence of interesting activities in learning, and 6) the existence of a conducive environment. Based on the analysis of product moment correlation test stated there is a significant influence between the provision of teacher empowerment to students' learning motivation X class of administrative skill competence of 23.1 percent with a moderate level of influence. From the results of simple regression analysis showed that there is a significant and positive influence between the reinforcement of teachers to the motivation of students in class X competence of administrative skills in VOCATIONAL SCHOOL YPLP PGRI 1 Makassar.


THE New York Herald Tribune deserves the commendation of every member of the chemical profession and industry for publishing as part of the Sunday edition of Sept. 21, a special section reporting the highlights of the Atlantic City meeting of the ACS. Although the decision to print the special section was made rather late, it was well supported in an advertising sense by chemical companies who are alert to the need of educating the public on what the chemist, the chemical engineer, and the chemical industry contribute to the welfare, safety, and happiness of the citizens of this country. The Sunday edition of the Herald Tribune reaches more than a million readers with a large national distribution as well as a very heavy concentration in the New York metropolitan area. It is our understanding that Herald Tribune officials are giving serious thought to making the special section an annual affair—to be published immediately following ...


Purpose – To identify effective literacy instructional strategies and methods based on assessment. Also, to provide information on literacy experts that teachers may seek advice from as they work with striving readers.

Approach – A review of literature and the research on teaching striving readers were examined.

Practical implications – Reading is an important determining factor in efficacious learning and overall literacy; students must possess the necessary literacy skills to become successful and productive citizens in an information age. Throughout the chapter, a striving reader is presented while offering the reader an authentic example of a striving reader. The strategies, methods, and experts offer best practices; these will enhance the student(s) literacy skills.

Originality/value of paper – Educators utilizing the information provided in this chapter will be enhanced in their ability to effectively teach their students.


Objective To study the effects of soybean isoflavone(SI) on lipid peroxidation and liver ultrastructure in ovariectomized rats. Methods Seventy female Sprague-Dawley(SD) rats were randomly divided into 7 groups according to the levels of total cholesterol(TC) in serum: hyper-lipoid group,estrogen group,low-dose SI group,middle-dose SI group,high-dose SI group,sham group and normal control group.After bilateral ovaries were extirpated except sham and normal control groups for a week,the estrogen,different doses of SI or deionized water were fed with intragastric administration for 12 weeks.The rat body weight was weighted once per week and blood samples were collected at the time of ovariectomization,the 4th and 8th weeks after administeration at the time of being killed.The serum TC,triglyceride(TG),high or low density lipoprotein-cholesterol(HDL-C,LDL-C),lipoprotein(a) and antioxygen enzyme were assayed. Results LDL-C levels in SI intervention groups were significantly lower than that in hyper-lipoid groups but higher than that in normal control group;the levels of lipoprotein(a) were changed;there was almost no effect on HDL-C in serum.SI could retain integrity and ultrastructure of hepatocyte;there was similar structure in high dose SI group and normal control group.An obvious damage was detected in hyper-lipoid group.Conclusion SI can improve lipoprotein(a) and lipid peroxidation in ovariectomized rats.A continuous intervention with high-SI can reduce LDL-C to normal lever and retain integrity and ultrastructure of hepatocyte.


MITRE ATT&CK techniques and their respective detections, while a significant step forward in democratizing threat intelligence, are predominantly focused on endpoint visibility through direct management or via agents. Some detection approaches leverage network sensors (e.g., Zeek) like BZAR (Fernandez, Wunder, Azoff, & Tylabs) in network-based detection of ATT&CK techniques. However, many of these earlier solutions focus on Microsoft Windows-specific protocols. They do not provide broad coverage of less-sophisticated endpoints, industrial systems, or infrastructure devices themselves (such as routers, switches, wireless devices). This paper will explore the feasibility of network-based detections using combinations of CLI utilities and Zeek IDS to augment or replace endpoint-focused detections and extend ATT&CK's utility to the rest of the network. © 2 02 0 T he SA NS In sti tut e, Au tho r R eta ins Fu ll R igh ts © 2020 The SANS Institute Author retains full rights. Using Network Telemetry to Detect MITRE ATT&CK Techniques 2


A selective literature review resulted in the conceptualization of a model illustrating the expected relationships of antecedents, processes, practices, and consequences of truckload carriers in the transportation industry. Thus, collection of data and analysis is recommended if the model and applicable theory are to be developed to the fullest extent possible. Accordingly, the authors provide a working model that illustrates the basis for investigating the conceptualized relationship among work climate relationships, job satisfaction, organizational commitment, turnover intentions and/or retention, crash rates, and residual costs. Limited empirical evidence exists that correlates a combination of these factors. In addition, a diminished level of organizational commitment may affect truckload drivers' attitude and/or focus while operating these very large trucks and as a result lead to an increase in crashes. Injuries, fatalities, and accident costs are reviewed as evidence of the magnitude and consequences of truckload crashes. The conceptual model advanced in this study emphasizes the essential need for a fully developed and empirically proven model and includes propositions to examine the strength and direction of relationships among important constructs, processes, practices, demographic, and environmental variables. Suggestions for further research based on the literature reviewed are discussed.


In this paper, effects of lattice strain on dielectric properties of Sr1−xCaxBi2Nb2O9 (x=0.0–0.5 in steps of 0.1) ceramics are reported. High frequency dipolar polarization is observed to increase for 10% calcium addition and suppresses thereafter on higher calcium concentrations. The dielectric loss values for all doped samples were lower compared to undoped one at frequencies beyond 1kHz. The sample with x=0.1 shows room temperature dielectric constant in the range (130±12) over a wide frequency range from 50Hz to 1MHz also minimum dielectric loss among all other sample for the same frequency range. Remarkable increase in Curie temperature (Tc) by 50∘C is recorded in the present work by increasing 10% calcium content in SBN compostion. All higher doped samples indicate increase in Tc by further higher amount. In addition, dc conductivity of all samples is measured for all samples and increase in calcium content is observed to generate more insulating compositions compared to undoped SBN with higher intrinsic activation energies.


The influence of additionally injected short-wavelength photobleaching light on the radiation hardness of Ge-doped graded index fibres working at 1300 nm wavelength is investigated. Predictions are complicated by the fact that more efficient shortwave bleaching light experiences higher radiation-induced loss. Promising results are found for low fibre temperatures (/spl lsim/-50/spl deg/C) and bleaching light of about 835 nm wavelength.


With expanding the dimensions of ER method,this paper proposed an analytical algorithm to compute the coefficient matrix in the perspective of individual rationality. Based on the assigned persons' individual rationality,the method could combine the qualitative data,quantitative data and fuzzy data simultaneously. And more importantly,we proved that the traditional solution must correspond to the Nash equilibrium. Therefore,we complete the entire calculation process of the assignment model based on individual rationality. Finally,an interview planning example is examined to show the implementation process of the proposed approach.


Oil jet lubrication performance directly influences the operation, reliability and fatigue life of meshing gears working under high-speed and heavy-load conditions in the main reducer of rotorcraft. An oil-air two-phase mixture flow numerical simulation model for jet lubrication on the surface of a pair of meshing gears was established by the computational fluid dynamics (CFD) simulation code ANSYS/FLUENT. The effects of the spin flow caused by a high-speed rotating gear pair on the jet flow trajectory deviation were considered in the numerical simulation. The oil volume and oil pressure distribution characteristics of the meshing area were obtained and compared according to different nozzle position layouts, and the optimal nozzle position layout was determined to obtain a maximum oil volume and oil pressure. A gear-jet-lubrication experimental system was built in which the meshing surface temperatures were measured by an infrared thermometer; meanwhile, the jet flow trajectories were photographed by a high-speed camera. The experimental and numerical simulation results were mutually validated and proved the proposed optimal design scheme for the nozzle position layout. (Received, processed and accepted by the Chinese Representative Office.)


What is "music in the Baptist tradition"? There are two basic ap proaches to answering this question: a "produced-by-Baptists" approach and an "accepted-by-Baptists" approach. Although Baptists have had a history of using music in their worship for several centuries, they (as well as most other denominations) have refused by-and-large to use only music (and texts) originating among themselves. Indeed, a survey of most Baptist hymnals and perhaps even most printed orders of worship for Baptist church services would probably reveal the use of a large percentage of music written by non-Baptists. Thus Baptists in their use of music have defined their musical tradition to include music not only by Baptists but also by others as well.


The Precambrian crust of Central India comprises two Archaean cratonic domains, namely, Bundelkhand in north and Bastar in south, which were accreted along the ENE–WSW trending Proterozoic Central Indian Tectonic Zone (CITZ) bounded between the Son– Narmada North Fault (SNNF) and the Central Indian Shear Zone (CIS), and extending for more than 800 km in length and 120–150 km wide. The CITZ contains lowto medium-grade Proterozoic supracrustal belts set amidst migmatitic gneisses and granitoids. The Mahakoshal supracrustal belt, a northern part of CITZ is a prominent fault-controlled asymmetrical rift basin. It extends for more than 600 km along strike and forms an E–W to ENE–WSW trending terrain along the Son–Narmada lineament, wherein it is bounded by SNNF in the north and South Narmada South Fault (SNSF) in the south. It comprises chemogenic and volcano-sedimentary sequences of Greenschist facies (Roy et al. and Acharyya, and references therein). The carbonaceous phyllite (CP) of Agori Formation, Mahakoshal Group which is confined within the shear zone was first observed by Kanchan and Pandhare. The presence of graphite based on softness and finger soiling within this CP was vaguely speculated. Subsequently, CP was mapped at 1 : 25,000 (ref. 5). Random samples of CP analysed gave fixed carbon values up to 3.2%. An exploration programme was formulated to undertake 'mapping of the area, confirmation and delineation of graphite, its systematic channel/groove sampling, ore microscopy, EPMA studies, fixed carbon analysis and Major-Trace-REE geochemistry'. During the course of mapping at 1 : 12,500, it was observed that CP (Figure 2 a and b) extends intermittently over cumulative strike length of ~10.3 km and ~40 m average width (Figure 1). The steep inclinations of ~80°–85°SSE, extensive brecciation, crushing, secondary ferruginization, numerous quartz veins, quartz porphyroclasts and large-scale silicification were observed in the shear zone trending ENE–WSW and having strike length of about 8 km. The flaky carbon lenses within the CP, were systematically sampled at 25 × 5 m interval. They were distinguished by their greyish-black colour, flaky and splintery nature, metallic lustre and comparatively low specific gravity. The possibility of flaky carbon lenses being graphite was checked in the field (powder was immersed in a glass full of water, wherein flakes were found to float), which strongly suggested the


Introduction: Human papillomavirus (HPV) infection is known to cause cervical cancer worldwide. Recently, Malaysia introduced HPV DNA detection testing for cervical cancer screening program. However, knowledge regarding factors for HPV infection among women still limited. Thus, this study aimed to determine the prevalence and factors associated with HPV infection among women in Kelantan, a north-eastern state of Malaysia. Methods: This study used secondary data extracted from HPV DNA test registry book and HPV DNA laboratory request forms. Data on all Malaysian women aged 30 to 49 years old in 2019 reported in registry book were included. Simple random sampling was applied. All information from book and forms were collected using proforma and analysed using SPSS. The outcomes were categorised into HPV infection and non-HPV infection. The parameters related to factors associated with HPV infection were determined using multivariable logistic analysis. Results: The prevalence of HPV infection among women attending the new cervical screening was 8.4% (95% CI 6.4%, 10.3%). Those aged between 30 and 39 years old (AdjOR 2.09; 95% CI 1.16, 3.78, p=0.014), had 5 or more parities (AdjOR 2.82; 95% CI 1.58, 5.06, p<0.001) and hormonal contraception users (AdjOR 7.48; 95% CI 4.07, 13.76, p<0.001) were significantly associated with HPV infection. Conclusion: Overall, the prevalence of HPV infection from this study is comparable to the local and international studies. Age, number of parities and hormonal contraception users influence the HPV infection. This finding could help in designing more targeted screening for cervical cancer.


The industrial oil plants are important feedstocks of energy,chemical and bio-material resources. Large-scaled utilizationin of industrial oil plants are meaningful to saving farmland,improving the ecological environment,increasing the income of the farmers and cultivating new economic growth point. Technologies of utilization industrial oil plants included preparing oil effectively and,converting cleanly to biodiesel,biolubricant,printing ink resin and asphalt material products. This review summarized the progress of research on the new technology of oil plant resources in industrial usages,and the industrialization prospects were also evaluated and prospected.


This paper presents a design and implementation of a 1 kHz, 10 kV, positively pulsed trigger generator with an average risetime of 44 ns for use in a coaxial ferrimagnetic Nonlinear Transmission Line (NLTL) High Power Microwave (HPM) system. The pulse trigger generator is based on two stacked 4 kV current-controlled n-type thyristors in a low inductance package capable of driving inductive loads with risetimes less than 200 ns. However, by implementing a magnetic switch this relatively is slow risetime is sharpened to tens of nanoseconds. The stacked boards allow for voltage addition at the output while maintaining the fast riestime.


The paint industry is not immune to the dual problems of an ever‐decreasing supply of oil and natural gas, coupled with what some would call the predatory objectives of OPEC. The paint industry has a need for energy, and this need starts with its raw materials. To be sure, there is today a "glut" of energy. And it is predicted that this glut will exist until the end of 1985. But sooner or later the energy short‐age will be felt, and the paint industry will not be immune.


With the rapid progress of globalization,English graduates are facing increasing challenges from job market.The English graduates from Hebei higher educational institutes have not lived up to such level.In order to make students more competitive,we have analyzed the situation of the English programs in Hebei Province,recommended proposals and practices in line with the features of English program orientation and curriculum setting.


Abstract : This compilation is an integral part of the training material for DTIC's DoD STINFO (Scientific and Technical Information) Manager Training Course. It includes regulations, forms, and other documentation that support the DoD Scientific and Technical Information Program (STIP) and the implementing military services programs. The compilation is an aid to the operation and management of STI activities. The document is organized into tab index dividers for insertion in a binder, facilitating updating by the user. The table of contents lists the inclusive titles and includes a brief description of the purpose of each publication. Attendance at the course includes the training manual and the STINFO Documentation.


In this paper a brief synthesis of some psychological interventions applied to alcohol dependents is carried out. Some behavioural and cognitive techniques such as aversive techniques, training in incompatible behaviours and relapse prevention programmes pointed towards abstinence are revised. Some of the difficulties found in their application and some others aspects related to effectivity of treatments in this addictive behaviour are commented.


Objective To investigate the relationship between masked hypertension and morning blood pressure surge,and to provide appropriate guidance for clinical treatment.Methods According to the casual and dynamic blood pressure measurements,310 subjects were divided into three groups: hypertension group(n=100),masked hypertension group(n=85)and normal blood pressure group(n=125).General data,dynamic blood pressure parameters and occurrence of morning blood pressure surge were analyzed in the three groups.Results Compared with normal blood pressure group,dynamic blood pressure parameters obviously increased in hypertension group and masked hypertension group(P0.01).However,differences were not significant between the two groups(P0.05).The incidence and value of morning blood pressure surge were,respectively,35.3% and(28.9±8.1) mmHg in masked hypertension group,22.4% and(24.7±9.6)mmHg in normal blood pressure group,and 51.0% and(34.8±12.7) mmHg in hypertension group.Differences were significant among the three groups(P0.05).Conclusion Masked hypertension is correlated with morning blood pressure surge,which can aggravate target organ damage.


This article focuses on the conservativeness issue of the existing Lyapunov method for linear time-invariant (LTI) nabla fractional-order systems and proposes a converse Lyapunov theorem to overcome the conservative problem. It is shown that the LTI nabla fractional-order system is asymptotically stable if and only if there exist a positive-definite Lyapunov function whose first-order difference is negative definite. After developing a systematic scheme to construct such Lyapunov candidates, the Lyapunov indirect method is derived for the nonlinear system. Finally, the effectiveness and practicability of the proposed methods are substantiated with four examples.


Inguinal hernia is a common surgical disease. Giant inguinoscrotal hernias are more unusual and impose significant impact on quality of life including difficulty with mobility, scrotal skin ulceration and bowel obstruction.  Besides it is more challenging in terms of surgical management. Diagnosis of giant inguinoscrotal hernia is straight forward on clinical examination. Nevertheless, with the advent of CT scan, pre-operative contrast-enhanced CT scan is useful for ascertaining the hernia contents, its configuration and measuring the neck of hernia. We report a case of a patient with extremely huge irreducible right giant inguinoscrotal hernias.


The distribution of directions of magnetic field vectors along the trajectory is found from the accelerations of a plasma formation moving in the tail of Halley's Comet. The magnitude of the field in the comet's tail proves to be greatest at the boundary and declines sharply within the tail. This means that there is a magnetic barrier at the boundary of the tail. A map of the magnetic field in the tail of Halley's Comet is constructed which agrees well with a laboratory model of an induced magnetosphere.


A hybrid data assimilation algorithm is developed for complex dynamical systems with partial observations. The method starts with applying a spectral decomposition to the entire spatiotemporal fields, followed by creating a machine learning model that builds a nonlinear map between the coefficients of observed and unobserved state variables for each spectral mode. A cheap low‐order nonlinear stochastic parameterized extended Kalman filter (SPEKF) model is employed as the forecast model in the ensemble Kalman filter to deal with each mode associated with the observed variables. The resulting ensemble members are then fed into the machine learning model to create an ensemble of the corresponding unobserved variables. In addition to the ensemble spread, the training residual in the machine learning‐induced nonlinear map is further incorporated into the state estimation, advancing the diagnostic quantification of the posterior uncertainty. The hybrid data assimilation algorithm is applied to a precipitating quasi‐geostrophic (PQG) model, which includes the effects of water vapor, clouds, and rainfall beyond the classical two‐level QG model. The complicated nonlinearities in the PQG equations prevent traditional methods from building simple and accurate reduced‐order forecast models. In contrast, the SPEKF forecast model is skillful in recovering the intermittent observed states, and the machine learning model effectively estimates the chaotic unobserved signals. Utilizing the calibrated SPEKF and machine learning models under a moderate cloud fraction, the resulting hybrid data assimilation remains reasonably accurate when applied to other geophysical scenarios with nearly clear skies or relatively heavy rainfall, implying the robustness of the algorithm for extrapolation.


The following paperwork was presented as a monograph text to judgment of the professors of the Languages Course at the Universidade do Planalto Catarinense. The aim of the paper work was to establish a connection between the terrors of Howard Phillips Lovecraft's life and the fear represented in his writings, especially the masterpiece horror tale "The Call of Cthulhu". The work was based on a strictly bibliographic research and developed through the review and decomposition of various literary texts. To characterize fear, a whole range of sources was consulted, including works in psychology, literature structure and fantasy horror literature previous to the author under analysis. The theoretical base for the text was chosen to support the analysis of fear in literature and in the life of the author. Names such as Stephen King and S. T. Joshi were used to establish the necessary connections for the development of the text. The internet was used to provide what money and location could not afford in the matters of reading, as well as Tzvetan Todorov and Felipe Furtado who helped to define the most technical components. The work was based in the analysis of fear in the historical and literary perspective. It was never the intention to evaluate fear as a negative or positive emotion; rather it was to correlate the work of a great writer to his life and background, as well as to question his intentions towards literature. As a result, it was found that fear was present as a main component of literature much before Lovecraft, though only after him it gained the shapes it has today. As from the analysis of the short-story "The call of Cthulhu", taking into account all that was previously read and discussed, the horror tale is dissected and exposed to its very nerve. In the light of references that were made, Cthulhu proves to be Lovecraft's greatest creation.


Wave variation on sloping-bottom platform is analyzed by adopting the calculation model for wave height variation when passing beach of arbitrary profiles.The result reveals that by adopting this model,the wave variation on sloping-bottom platform can be well estimated.


Unclear orientation and absence of characteristics have become the main facts which block the employment of engineering graduates in China. After the analyse and comparative of the objects and courses of universities and colleges in different levels, we can see that characteristics are the main disparity between Chinese engineering education and US engineering education.


E2 gene phage display peptides libraries of CSFV Shimen strain(SM-E2 libraries) were selected by CSFV monoclonal antibodies(MAbs) to screen the potential epitopes of CSFV-E2 protein.Four rounds of biopannings were carried out to the SM-E2 libraries using MAbs WH303,WH211,M56.The positive clones were identified by phage in Situ Hybridization,Sequence analysis and ELISA.After analyzing,the one sequence which was highly homologous with TAVSPTTLR,were screened by the MAbs 303.None was gained by WH211 and M56.Results suggested that the target gene phage-display library of random peptides is a novel tool for investigation into Antigenic epitopes.


Mechanical and seepage characteristics of raw coal samples are the most important research contents of enhancing coal bed methane recovery, but the produce of raw coal sample is very difficult. Based on gas seepage instrument, mechanical and seepage characteristics were performed on normal briquette coal samples and coal samples containing gypsum. The results show that it can increase the cohesion and intensity level by adding gypsum in briquette coal. Porosity and permeability of coal containing gypsum is less than ordinary briquette coal sample. Permeability with axial strain curves of two kinds of coal samples can be fitted with a quadratic function well. In expansion stage, volumetric strain of ordinary coal sample is much smaller than the coal samples containing gypsum. The research has an important guiding significance on enhancing coal bed methane recovery and gateway supporting.


Great advances have been made in understanding the pathogenesis, diagnosis, risk stratification and treatment of classic bcr-abl-negative myeloproliferative neoplasms(MPN). This article reviews current situation in the treatment of these MPNs presented in the 56th American Society of Hematology(ASH)annual meeting.

Key words:
Myeloproliferative neoplasm; Hydroxycarbamide; Interferon; JAK inhibitors; Targeted treatment; American Society of Hematology annual meeting