Significance The essential micronutrient zinc is known to modulate adaptive immune responses and dysregulated zinc homeostasis leads to immunodeficiency. However, the molecular mechanisms underlying this zinc-mediated modulation are unknown. We show that the zinc transporter ZIP10 plays an important role in B-cell receptor (BCR) signaling. Zip10-deficiency in mature B cells attenuated both T-cell–dependent and –independent immune responses. Zip10-deficient mature B cells proliferated poorly in response to BCR cross-linking, as a result of dysregulated BCR signaling. Our data establish that ZIP10 functions as a cellular regulator to modulate BCR signaling in humoral immune responses. The humoral immune response, also called the antibody-mediated immune response, is one of the main adaptive immune systems. The essential micronutrient zinc (Zn) is known to modulate adaptive immune responses, and dysregulated Zn homeostasis leads to immunodeficiency. However, the molecular mechanisms underlying this Zn-mediated modulation are largely unknown. Here, we show that the Zn transporter SLC39A10/ZIP10 plays an important role in B-cell antigen receptor (BCR) signal transduction. Zip10-deficiency in mature B cells attenuated both T-cell–dependent and –independent immune responses in vivo. The Zip10-deficient mature B cells proliferated poorly in response to BCR cross-linking, as a result of dysregulated BCR signaling. The perturbed signaling was found to be triggered by a reduction in CD45R phosphatase activity and consequent hyperactivation of LYN, an essential protein kinase in BCR signaling. Our data suggest that ZIP10 functions as a positive regulator of CD45R to modulate the BCR signal strength, thereby setting a threshold for BCR signaling in humoral immune responses.


Background & aim: Considering the importance of keeping the country population young and fertility control, particularly, in the elites and with regard to the influence of spiritual well-being on fertility behaviour and childbearing in the religious cultural context of Iran, the present study aimed to determine the relationship between spiritual well-being and fertility preferences in the selected higher education centers of Mashhad, Iran in 2019. Methods: This correlational study was carried out on 296 married students of Mashhad University of Medical Sciences and Razavi University of Medical Sciences in Mashhad, Iran, who were selected using multistage sampling between 2018 and 2019. The data were collected using three questionnaires of individual-educational characteristics, spiritual health, and Miller's Fertility Preferences and Childbearing Questionnaire. The data were analyzed using descriptive statistics and Pearson's correlation coefficient. Results: In terms of spiritual health, 222 (75.0%) students had a moderately score. Also, 143 (48.3%) subjects had a high level of willingness to have children. Regarding the number of children, 88 (29.7%) students tended to have two children, and 75 (25.9%) participants were inclined to have children within 1 to 2 years after marriage. There was a significant linear relationship between the spiritual health and fertility preferences of the students (r=0.29; p <0.001). Conclusion: It is recommended to develop a codified and local curriculum for the education of spiritual health, and its impact on the fertility preferences of the students. However, further studies in this regard are suggested.


This paper proposed a new modular inverse algorithm based on the right-shifting binary Euclidean algorithm. For an n-bit numbers, the number of operations for the proposed algorithm is reduced about 61.3% less than the classical binary extended Euclidean algorithm. The proposed algorithm implementation shows substantial reduction in computation time over Galois field GF(p).


This section presents a table of references in Irenaeus to passages from Genesis 1-11. A particular difficulty is encountered in attempting to tabulate references to Genesis 1.26, given that any occurrence of the phrase 'image and likeness' in the Irenaean corpus might be considered a partial direct quotation, even though no other reference may be made to the verse itself. For the entries on this verse alone, non-bracketed references are to sections in which Irenaeus' use of the terms 'image and likeness' seems intentionally aimed at calling to the reader's attention the context of Genesis 1. Bracketed references are to passages which utilise this phrase without any apparent intention on Irenaeus' part to relate his comment directly to the Genesis text.Keywords:Genesis 1-11; Irenaean corpus


Background: Spleniculi or accessory spleen, is a congenital anomaly occurring in 10% of individuals.  Spleniculi resembles normal spleen in structure and in immunological function. Certain hematological and radiological investigations can indicate residual splenic function. They can enlarge following splenectomy and be the source of recurrent symptoms in those operated on for hematological disorders.Methods: Authors did a retrospective study in a tertiary care hospital to estimate the incidence and to describe the location and number of spleniculi in patients undergoing splenectomy, both elective and emergency, over a 5-year period - October 2013 to October 2018. Total patients included was 186.Results: Majority of the patients were in the age group of 18-45years. 16 (8.6%) had spleniculi, found incidentally and confirmed histopathologically. Hematological disorders, out of which Idiopathic Thrombocytopenic Purpura 70 (49.6%) was the most common indication. Commonest location was in the hilum, 12 (75%), second being, near the tail of pancreas. 1 patient presented with a left hypochondriac mass, which was confirmed as enlarged spleniculi on histopathology, post - relook surgery.Conclusions: Accessory spleens are asymptomatic and have a high chance of being overlooked during splenectomy, which could be one of the causes of relapse in hematological disorders.


1 Interactions of benzodiazepines with adenosine on the neuromuscular transmission were studied in mouse diaphragm preparations 2 In tubocurarine (0.6‐0.8 μm)‐partially paralyzed preparations, diazepam (35 μm) and Ro 5–4864 (3∼30 μm), a peripheral type benzodiazepine receptor agonist, potentiated the inhibitory effect of adenosine on indirect twitch responses 3 The central type receptor agonist, clonazepam did not affect the inhibitory effect of adenosine 4 The peripheral benzodiazepine receptor antagonist, PK11195 (1–10 μm) attenuated the adenosine inhibition and antagonized the potentiation by Ro 5–4864 5 Ro 5–4864 failed to enhance further the inhibitory effect of adenosine in the presence of dipyridamole, an adenosine uptake inhibitor that also potentiated adenosine inhibition 6 Neither Ro 5–4864 nor PK 11195 affected the inhibition produced by a stable adenosine analogue, 2‐chloroadenosine, which is not a substrate for the adenosine uptake system 7 Ro 5–4864 did not affect endplate potentials (e.p.ps) in the absence of adenosine, but reduced the amplitude of e.p.ps in the presence of adenosine without affecting miniature e.p.ps 8 It is suggested that benzodiazepines potentiate the adenosine‐effected presynaptic inhibition of neuromuscular transmission by an inhibition of adenosine uptake through activation of peripheral type benzodiazepine receptors.


2014 On the cleavage surface of ferroelectric triglycine sulphate (TGS) nematic MBBA aligns in different ways on domains with opposite directions of spontaneous polarization. From light intensities passing through twisted nematic MBBA placed between a TGS sample and an anisotropic glass plate the director of MBBA on plus domains of TGS is determined to be close to [508] or [702] crystallographic directions of TGS. This alignment as well as the orientation of MBBA along [001] direction on minus domains are caused by anisotropic surface anchoring on the TGS cleavage surface. On the calculated relief, wide deep channels have been found which could account for the easy direction on minus domains. The easy direction on plus domains originates in an anisotropic interaction between nematic molecules and those of the crystal. In the paraelectric phase of TGS, both alignments described are possible. J. Physique 42 (1981) 1569-1572 NOVEMBRE 1981,


British East Asian actors have challenged the Royal Shakespeare Company over the casting in its upcoming production of the classic Chinese play, The Orphan of Zhao by Ji Junxiang. Support for the British East Asian actors has spread globally with statements flooding in from Asian actors' groups in America, Australia, Canada and other countries; as well as messages of support from theatregoers and the public on the RSC's Facebook site.


Since the establishment of the Economic Community of West African States in 1975, its acronym has become well known, even though 'E.C.O.W.A.S.' still means little more than a synonym for 'West Africa' and a symbolic tribute to the ideals of African unity. The Community has certainly witnessed a growth of its bureaucracy and institutions, but the limited co-operation actually achieved has been based on strengthening links which were developed in the region since the early 1960s rather than on the transfer of state prerogatives to Community organs on specific issues.


SrTiO 3 (STO) thin films were grown on Si wafer, Pt- and Ru-coated Si wafers, respectively, by an atomic layer deposition (ALD) technique using conventional metallorganic precursors, Sr(C 1 1 H 1 9 O 2 ) 2 (Sr(thd) 2 ) and Ti(Oi-C 3 H 7 ) 4 (TTIP) as Sr- and Ti-precursors, respectively, with a remote-plasma activated H 2 O vapor as the oxidant at a wafer temperature of 250°C. Patterned Si wafers with contact holes having a diameter of 0.13 and 1 μm depth (aspect ratio of 8) was used in order to test the film-thickness and cation-composition conformalities over the contact hole surface. The ALD behavior of the STO film was critically dependent on the Sr(thd) 2 source heating temperature. When the Sr source temperature was ∼200°C. This difficulty resulted in a nonuniform cation composition ratio along the contact hole.


K/Ar ages from east Nahuel Pan hills, Chubut. Implicance in the Divisadero and Choiyoi Groups correlation. A sequence of dacitic/andesitic flows and pyroclastic rocks, in discordance above basandesitic volcanic series at eastern Nahuel Pan hills, has been dated by K/Ar method. Samples of the flows and basandesitic volcanic rocks yield ages of 105 ± 5 Ma and 252 ± 10 Ma. These ages assign to the lavic-pyroclastic sequence a Cretaceous age (at the lower part of upper member of Divisadero Group) and to the basandesitic volcanic rocks a Permotriassic age (in line with Choiyoi Group). This is the first occurrence, of the Choiyoi Group, in the eastern slope of the Andes at this latitude.


Let f(1)=2, f(2)=4, and let f(n+1)=f(n)! for every integer n≥2. Edmund Landau's conjecture states that the set P(n^2+1) of primes of the form n^2+1 is infinite. Landau's conjecture implies the following unproven statement Φ: card(P(n^2+1))<ω ⇒ P(n^2+1)⊆[2,f(7)]. Let B denote the system of equations {x_i!=x_k: i,k∈{1,...,9}}∪ {x_i⋅x_j=x_k: i,j,k∈{1,...,9}}. We write down a system U⊆B of 9 equations which has exactly two solutions in positive integers, namely (1,...,1) and (f(1),...,f(9)). Let Ψ denote the statement: if a system S⊆B has at most finitely many solutions in positive integers x_1,...,x_9, then each such solution (x_1,...,x_9) satisfies x_1,...,x_9≤f(9). We write down a system A⊆B of 8 equations. Theorem 1. The statement Ψ restricted to the system A is equivalent to the statement Φ. Open Problem: Is there a set X⊆N that satisfies conditions (1)-(5) ? *** (1) There are many elements of X and it is conjectured that X is infinite. (2) No known algorithm decides the finiteness/infiniteness of X . (3) There is a known algorithm that for every k∈N decides whether or not k∈X. (4) There is a known algorithm that computes an integer n satisfying card(X)<ω ⇒ X⊆(-∞,n]. (5) There is a naturally defined condition C, which can be formalized in ZFC, such that for almost all k∈N, k satisfies the condition C if and only if k∈X. The simplest known such condition C defines in N the set X. *** We define a set X⊆N. We prove: (i) the set X satisfies conditions (1)-(5) except the requirement that X is naturally defined; (ii) the statement Φ implies that the set X={1}∪P(n^2+1) satisfies conditions (1)-(5). Proving Landau's conjecture will disprove the statements (i) and (ii). Theorem 2. No set X⊆N will satisfy conditions (1)-(4) forever, if for every algorithm with no inputs that operates on integers, at some future day, a computer will be able to execute this algorithm in 1 second or less. Physics disproves the assumption of Theorem 2.


Calibration model maintenance is often overlooked but is a significant part of successful use of multivariate calibration models, for example, in process monitoring and optimization. In some cases, companies are maintaining tens or even hundreds of calibration models. This could be partial least squares (PLS) calibration models pertaining to different recipes or raw materials or neural network based models covering different production sites. Maintaining such a high number of models is cumbersome and expensive. Sometimes, a solution presented for this problem is to merge all the models into one, but this often comes at the expense of significantly higher prediction errors. In this paper, we suggest a new approach for rationally merging calibration models in order to optimally balance the prediction error and maintenance workload. We do this by systematically merging models that lower the error as much as possible and hence provide a sort of optimal clustering or fusion of calibration models. We showcase the new approach on a case based on infrared spectroscopy applied to dairy production.


In recent years, there have been concerns raised about construction industrialization in China, which have initiated a wave of policy change in both governmental and industrial organizations in order to change the mode of conventional construction. However, the current development level of regional construction industrialization (RCI) in China has not been well-characterized. This study screened preliminary index systems in five dimensions: technical, economic, sustainable, enterprise development and development environment. Based on the data gathered from the questionnaire surveys and subsequently analyzed, twenty-two critical evaluation indicators were identified. Analytic Hierarchy Process (AHP) was then employed to determine the weighting of each indicator. The evaluation method of the development level was formulated on the basis of the evaluation criteria. Jiangsu Province was used as an example in this study, with the development level of this province being comprehensively examined using a combination of the index system and evaluation method. The results show that Jiangsu has a relatively high RCI development level. The data from analysis scores of five dimensions and twenty-two indicators show that the index system is feasible, with evaluation results being consistent with actual practice. These findings provide a good practical reference for making decisions about how best to guide the development of RCI.


As a promising photocatalysts and light absorber for solar cells, nano-sheet like Cu2Cu1−xMnxSnS4 (CCMTS) was synthesized by manganese (Mn) doping of orthorhombic Cu3SnS4 (CTS). The bandgap and morphology of the products vary with the addition of manganese (II) acetate tetrahydrate (MnC4H6O4·4H2O) injected in the precursor. The bandgap of CCMTS decreases from 1.67 to 1.45 eV with increasing concentration of MnC4H6O4·4H2O from 0 to 0.016 M. Light absorbance of all the as-synthesized CCMTS samples maintained at a high level. The substitution of Mn2+ for Cu2+ induces grain refinement and formation of amorphous layers at the boundaries of the crystalline grains when the MnC4H6O4·4H2O content exceeds 0.012 M in the precursor.


Possibility of replacing whole soy flour for chocolate fat in chocolate production and its impact on textural, rheological and sensory properties of low fat chocolate was explored. For doing this, whole soy flour in 5 levels (0, 2,4,6,8 percent) and two refining times (105 and 135 minutes) was employed. Results indicated that longer refining time gave rise to reduction in particles size and increase in hardness of chocolate. With increasing refining time from 105 minutes to 135 minutes, hardness showed an upward trend which rose from 7100g to 8180g. Casson yield value and Casson viscosity ranged between 9.02 Pa to 35.09 Pa and 2.55 to 5.99 (Pa.s), respectively . Data revealed that whole soy flour up to 4% can be successfully substituted for chocolate fat, without causing significant difference in textural, rheological and sensory properties of chocolate samples (P<0.05).

Keywords: Whole soy flour, Sensory properties, Textural properties, Rheological properties, Palm oil, Chocolate


which occupied lower ground, down toward the creek. Two dogs, one yellow and one black and white, leaped and howled, but they were the only ones to meet him. He walked past the big house, which was his father's, and went to the cabin, his mother's. There she was, as he knew she would be, sitting in the shade. If she heard him she did not look up at once. But she was a little deaf and a little blind — perhaps she had not sensed his approach. He let the heavy suitcase slip from his sweating hand. Then she looked up. A sigh escaped her and a quick smile multiplied the many fine lines in her wrinked brown face.


The presentation of the patient with acute cholangitis (AC) ranges from mild illness to life‐threatening shock. Therefore, prompt diagnosis and treatment are critical. Abdominal ultrasound (US) is the imaging of choice to locate bile duct dilatation. Other modalities include abdominal computed tomography (CT) or endoscopic retrograde cholangiopancreatography (ERCP).


Urban tourist destinations in Malang City have been growing in the last ten years. This growth is initiated not only by government programs to stimulate creative industries, but also by people enthusiasm to the development of thematic villages (kampung tematik). In the beginning, the planning of urban tourist destinations remains unclear about what direction to go, but it is then possibly compensated by great passion of people to design what then so called thematic villages.


"Modern‐diseases" that are result of "high sugar, low nutrient" diet are becoming more prevalent. Incorporation of "traditional" gluten‐free cereals, like proso, in "everyday" food, such as rusks, would allow diabetics and people looking to increase fiber and nutrient content to include rusks in their diet.Compared to wheat rusks, rusks with addition of proso showed higher content of microelements and essential amino acids. Also, higher content of dietary fiber and smaller and more regularly arranged starch granules increased digestibility of rusks with addition of proso. Additionally, rusks with addition of proso showed better antioxidative properties and had lower glycemic index when compared to wheat rusks.Incorporation of proso flour in rusk production, could be beneficial not only to people suffering from diabetes, but also as way of improving general well‐being. However, due to the decreased water absorption and therefore greater hardness and fracturability, our results suggested that addition of proso flour should be capped at 20 %.To our knowledge, this is the first description of effects on different additions of proso on digestibility, starchmorphology, glycemic index and nutritive and antioxidative properties of rusks.This article is protected by copyright. All rights reserved.


In the article, we consider a boundary value problem for a nonlinear ordinary differential equation of even order which, obviously, has a trivial solution. Sufficient conditions for the existence and uniqueness of a positive solution to this problem are obtained. With the help of linear transformations of T. Y. Na [T. Y. Na, Computational Methods in Engineering Boundary Value Problems, Acad. Press, NY, 1979, ch. 7], the boundary value problem is reduced to the Cauchy problem, the initial conditions of which make it possible to uniquely determine the transformation parameter. It is shown that the transformations of T. Y. Na uniquely determine the solution of the original problem. In addition, based on the proof of the uniqueness of a positive solution to the boundary value problem, a sufficiently effective non–iterative numerical algorithm for constructing such a solution is obtained. A corresponding example is given.


Traditional one-dimensional, two-dimensional probe can only measure the micro displacement in one or two directions of space, therefore highly-efficient and highly-precise measurement requirements of the surface of the complex gear can't be satisfied. Because 3D scanning probe can measure the micro-displacement in three mutually perpendicular directions of space, with it, continuous scanning motion measurement can be achieved and a large number of data points in three directions of space can be measured in a very short time, it is widely used in gear measurement industry at home and abroad. However, because of the limitations of mechanical structure of 3D scanning probe, installation errors and environmental factors, the measured three directions can't always be strictly vertical, and in the measurement, there will be the interference and the coupling phenomenon among the three directions. The study about how to ensure the highly precise characteristics of 3D scanning probe using a reasonable calibration method has become hot and difficult. In the paper, a new calibration method is proposed, the different regions on the standard ball were continuously contacted by 3D scanning probe, and let the probe step 10 times on the each contact point of standard ball, 10 group of points data were read out. The point of subsection was determined based on the deformation of the probe in the experiment, the data of the probe collected in each segment were fitted by using of the least squares method. Several calibration matrices were so obtained, the precise calibration of 3D scanning probe can be achieved. This method is finally verified by experiment. The experimental results show that the method of calibration is feasible, and has the advantages of high-speed and high-precision, which lays a solid foundation for high-precision measurement of 3D scanning probe.


The effect of X-ray soft annealing on the electrical properties of p–n junction diodes has been investigated. Under a forward bias of 1.0 V at 303 K, the forward current is approximately two orders of magnitude higher for X-ray annealed than for non-X-ray annealed samples. This effect is further investigated by evaluating the following properties under forward-bias conditions: ideality factor, saturation current, activation energy, series resistance, under reverse-bias conditions, carrier-generation lifetime, and activation energy. Results suggest that X-ray soft annealing improves the electrical properties of p-n junction diodes under forward-bias conditions.


There are multiple physical factors interfere with the accuracy of estimated glomerular filtration rate derived from serum creatinine-based Modification of Diet in Renal Disease formula (eGFR MDRDcreat). In this study, we examined whether by adding further stageing with eGFR derived from serum cystatin C-based Chronic Kidney Disease Epidemiology Collaboration formula (eGFR CKD-EPIcys) or eGFR derived from serum creatinine-cystatin C-based CKD-EPI formula (eGFR CKD-EPIcreat-cys) will improve the prognostic evaluation of kidney function. A total of 380 diabetic patients were followed (mean=5.6 years) for developing a CKD progresssion or kidney failure. Patients were staged by baseline eGFR MDRDcreat. By using eGFR CKD-EPIcys and eGFR CKD-EPIcreat-cys, 200 and 145 patients could be further reclassified into different stages respectively. For either outcome, reclassification of patients with G2 or G3 stage by eGFR CKD-EPIcys into a worse stage was associated with higher incident rate whereas those reclassified into a better stage was associated with lower incident rate. However, the improvement of prognostic evaluation of kidney function by reclassification with eGFR CKD-EPIcreat-cys was limited to G3 stage patients. In conclusion, our findings suggest that adding further CKD staging by eGFR CKD-EPIcys will help to improve the prognostic evaluation of kidney function in diabetic patients.


The brain tumors are by far the most severe and violent disease, contributing to the highest degree of a very low life expectancy. Therefore, recovery preparation is a crucial step in improving patient quality of life. In general , different imaging techniques such as computed tomography ( CT), magnetic resonance imaging ( MRI) and ultrasound imaging have been used to examine the tumor in the brain, lung , liver, breast , prostate ... etc. MRI images are especially used in this research to diagnose tumor within the brain with classification results. The massive amount of data produced by the MRI scan, therefore, destroys the manual classification of tumor vs. non-tumor in a given period. However for a limited number of images, it is presented with some constraint that is precise quantitative measurements. Consequently, a trustworthy and automated classification scheme is important for preventing human death rates. The automatic classification of brain tumors is a very challenging task in broad spatial and structural heterogeneity of the surrounding brain tumor area. Automatic brain tumor identification is suggested in this research by the use of the classification with Deep Belief Network (DBN). Experimental results show that the DBN archive rate with low complexity seems to be 97 % accurate compared to all other state of the art methods.


Object:To study the influence of endurance training on the ultrastructure and the dynamic variation of IGF-I in tendon.Method:20 male Sprague-Dawley rats were divided into 2 groups randomly,and the experimental groups were subjected to running exercises for 12 weeks.After training,the ultrastructural changes of the tendon and IGF-I expression were observed.Result:The observation show the tendon cells increased after the exercise training.The content of IGF-I mRNA and protein were significantly increased compared with the control group.Conclusion:Tendon can adapt to the exercise training,IGF-I may play an important role duing the adaptive construction of the tendon exercise.


This study was conducted to obtain answer for four research questions: (1) whether the effecivenes of audit committee affected whistleblowing system, (2) whether the effectivenes of internal audit affected whistleblowing system, (3) whether whistleblowing system affected fraud disclosure, and (4) whether fraud disclosure affected market reaction. This research was analyzed using Structural Equation Modeling SEM with PLS model. The samples were 57 companies that listed on the IDX  in year 2014. Results of the study were summarized as follow:  (1) The effectivenes of audit committee had negative significant effect on whistleblowing system, (2) The effectiveness of internal audit did not have effect on whistleblowing system, (3) whistleblowing system did not have effect on fraud disclosure, and (4)  fraud disclosure had negative significant effect on stock market reaction. The implication of this research is that the company should encourage the implementation of whistleblowing system as an effective early fraud prevention system, hence the number of fraud will decrease.


The analysis of Balmer-dominated emission in supernova remnants is potentially a very powerful way to derive information on the shock structure, on the physical conditions of the ambient medium and on the cosmic-ray acceleration efficiency. However, the outcome of models developed in plane-parallel geometry is usually not easily comparable with the data, since they often come from regions with rather a complex geometry. We present here a general scheme to disentangle physical and geometrical effects in the data interpretation, which is especially powerful when the transition zone of the shock is spatially resolved and the spectral resolution is high enough to allow a detailed investigation of spatial changes of the line profile. We then apply this technique to re-analyze very high quality data of a region along the northwestern limb of the remnant of SN~1006. We show how some observed features, previously interpreted only in terms of spatial variations of physical quantities, naturally arise from geometrical effects. With these effects under control, we derive new constraints on physical quantities in the analyzed region, like the ambient density (in the range 0.03-$0.1{\,\rm cm^{-3}}$), the upstream neutral fraction (more likely in the range 0.01-0.1), the level of face-on surface brightness variations (with factors up to $\sim 3$) and the typical scale lengths related to such variations ($\ge 0.1{\,\rm pc}$, corresponding to angular scales $\ge 10{\,\rm arcsec}$).


We provide an in-depth comparison of US and UK shareholder proposal rules and relate the differences in rules to differences in proposing activities, using comprehensive shareholder proposal data from both countries for 2000-2006. UK proposal rules are more onerous on proposal sponsors, but UK proposals are a more powerful governance device than US counterparts, because they are binding and UK shareholders have the statutory right to call special meetings and elect directors. Consequently, we observe most UK proposals are presented at special meetings and target board election. Institutions are the most active sponsor of UK proposals. As US proxy rules emphasize shareholder participation and protection rather than empowerment, there are a significantly greater number of shareholder proposals initiated in the US during the sample period, and small shareholders and social proposals dominate the proposing scene of the US.


We consider the problem of assigning tasks to homogeneous nodes in the distributed system, so as to minimize the amount of communication, while balancing the processors" loads. This issue can be posed as the graph partitioning problem. Given an undirected graph G=(nodes, edges), where nodes represent task modules and edges represent communication, the goal is to divide n, the number of processors, as to balance the processors' loads, while minimizing the capacity of edges cut. Since these two optimization criteria conflict each other, one has to make a compromise between them according to the given task type. We propose a new cost function to evaluate static task assignments and a heuristic algorithm to solve the transformed problem, explicitly describing the tradeoff between the two goals. Simulation results show that our approach outperforms an existing representative approach for a variety of task and processing systems.


with the purpose of accounting for the dimensions of displacement and the sociolinguistic factors to which these studies give greater attention. To achieve this task, a theoretical discussion is proposed on the phenomenon of sociolinguistic displacement, the dimensions and the factors that activate it, then, with the help of the Atlas.ti program, various propositions and textual units containing categories and subcategories are classified. These propositions and textual units integrate different dimensions of displacement and of the sociolinguistic processes that the language goes through. The study concludes with some reflections referring to the gaps around the sociolinguistic study of Mapudungun in the context of the processes of maintenance and/or displacement.


Let R be an associative noncommutative ring with identity. Let Specl (R) be all prime left ideals of R. In the present study, we will give some new characterizations of Specl (R) with the Zariski topology. Mathematics Subject Classification: 13D45, 13E10


Summary

1
It was once assumed that commercially important fish make up significant portions of seal diets. As a consequence, prior to the 1970s many seal populations were dramatically reduced by rampant slaughtering. Today, seals and other marine mammals are valued components of marine ecosystems and their numbers are carefully managed. To facilitate management, government statutes mandate the systematic monitoring of seal populations. Population estimates are based on counts of hauled-out seals obtained by aerial survey and radio and satellite telemetry; hence, considerable effort has been devoted to finding optimal times for such counts. We have developed a predictive mathematical model of seal haul-out to assist resource managers in the selection of optimal census times.

2
Haul-out depends on a number of environmental variables. Some of these variables, such as wind speed, can be obtained only as historical data or short-range predictions. Others, such as tide height, are deterministic and can be obtained as long-range predictions.

3
We used deterministic environmental variables to develop mathematical models that describe haul-out dynamics of harbour seals Phoca vitulina during the pupping season at a site in Washington, USA. A list of alternative hypotheses for environmental cues gave rise to a suite of competing models. We used information–theoretic model selection techniques to choose the best model. The selected model was a function of tide height and current direction, and explained 40% of the variability in hourly census data.

4
An assumption that the system recovers rapidly after disturbance introduced two time scales. This allowed the differential equation model to be reduced to an algebraic equation.

5
Synthesis and applications. This study demonstrates that resource managers can use a simple algebraic equation based on deterministic environmental variables to predict times at which to census maximal haul-out in harbour seals. At the Washington site, maximal daily haul-outs during pupping season are predicted to occur during receding tides, approximately midway between high and low tides. The largest maximal daily haul-outs during the pupping season are predicted to occur in the last week of July. The environmental factors correlated with haul-out are, however, site-specific; therefore the model developed for the Washington site will not necessarily hold for other haul-out areas. Managers should carry out the model selection procedure separately for each monitored haul-out site. The general methodology employed in this study can be used to make long-range predictions of diurnal movements for a variety of marine birds and mammals.


Theories of binary star formation by capture, separate nuclei, fission and fragmentation are compared, assessing the success of theoretical attempts to explain the observed properties of main-sequence binary stars. The theory of formation by fragmentation is examined, discussing the prospects for checking the theory against observations of binary premain-sequence stars. It is concluded that formation by fragmentation is successful at explaining many of the key properties of main-sequence binary stars.


The central theme of this paper is contradictions: the ways in which official agendas of internationalisation in higher education are disturbed by the principles of inclusion and exclusion in the local context of university academic culture. The case of South Korea shows how the national policies for the inter-nationalisation of higher education are translated into local cultural practice inside academe: What are the 'positions' of foreign and female academics in the specific national university context? How are they constructed by official policies of inter-nationalisation? How are they experienced by individuals to form new reflexive identities? The paper offers an illustrative analysis of the positioned and positional identities of foreign and female academics and the boundaries of inclusion and exclusion drawn around their identities. This exploratory study is aimed at future research agendas for a larger theoretical study on internationally mobile academics in different social contexts.


Vegetation in semideserts often self-organizes into spatial patterns. On gentle slopes, these typically consist of stripes of vegetation running parallel to the contours, separated by stripes of bare ground. The Klausmeier model is one of the oldest and most established of a number of mathematical models for this "banded vegetation." The model is a system of reaction-diffusion-advection equations. Under the standard nondimensionalization, one of its dimensionless parameters ($\nu$) reflects the relative rates of water flow downhill and plant dispersal and is therefore very large. This paper is the fifth and last in a series in which the author provides a detailed analytical understanding of the existence and form of pattern solutions (periodic travelling waves) of the Klausmeier model, to leading order as $\nu\rightarrow\infty$. The problem is a very rich one because the underlying mathematics depends fundamentally on the way in which the migration speed $c$ scales with $\nu$. This paper concerns the case...


In this paper we present preamble design for millimeter-wave single carrier wireless personal area networks. Several factors are considered for a successful preamble design, such as sequence complexity, operation range, associated delay, robustness to frequency offset. Complementary Golay sequences are selected, which combine flexibility and performance. Simula- tion results indicate at optimum threshold level, it is possible to reduce both false alarm probability and miss detection probability less than 10 �3 in non-line-of-sight channels.


Blockade of KIR3DL3 is an immunotherapy for human cancers. KIR3DL3-HHLA2 interactions protect tumors HHLA2 (a B7 family member) has both immune inhibitory and activating abilities and is expressed in many human cancers. These differing functions rely on the receptor to which it binds, yet many of these receptors are uncharacterized. Here, Wei et al. found that KIR3DL3 bound to HHLA2 and was expressed on effector memory CD8+ T cells and CD56dim NK cells. Interactions of KIR3DL3 with tumoral HHLA2 inhibited the function and killing capacity of both CD8+ T cells and NK cells. KIR3DL3+ immune cells infiltrated various types of HHLA2+ tumors from patients with cancer, and blockade of KIR3DL3 inhibited the growth of tumors in various mouse models. Thus, KIR3DL3-HHLA2 inhibits immune-mediated clearance of tumor cells and presents a possible immunotherapeutic target for cancer. The B7 family ligand HERV-H LTR–associating protein 2 (HHLA2) is an attractive target for cancer immunotherapy because of its coinhibitory function, overexpression in human cancers, and association with poor prognoses. However, the knowledge of the HHLA2 pathway is incomplete. HHLA2 has an established positive receptor transmembrane and immunoglobulin (Ig) domain containing 2 (TMIGD2) but a poorly characterized negative receptor human killer cell Ig-like receptor, three Ig domains, and long cytoplasmic tail (KIR3DL3). Here, KIR3DL3 and TMIGD2 simultaneously bound to different sites of HHLA2. KIR3DL3 was mainly expressed on CD56dim NK and terminally differentiated effector memory CD8+ T (CD8+ TEMRA) cells. KIR3DL3+ CD8+ TEMRA acquired an NK-like phenotype and function. HHLA2 engagement recruited KIR3DL3 to the immunological synapse and coinhibited CD8+ T and NK cell function and killing, inducing immune-evasive HHLA2+ tumors. KIR3DL3 recruited SHP-1 and SHP-2 to attenuate Vav1, ERK1/2, AKT, and NF-κB signaling. HHLA2+ tumors from human kidney, lung, gallbladder, and stomach were infiltrated by KIR3DL3+ immune cells. KIR3DL3 blockade inhibited tumor growth in multiple humanized mouse models. Thus, our findings elucidated the molecular and cellular basis for the inhibitory function of KIR3DL3, demonstrating that the KIR3DL3-HHLA2 pathway is a potential immunotherapeutic target for cancer.


Conditioned pessimism. That is the term Ed Sullivan, chief economist for the Portland Cement Association, used to describe the attitude and outlook of citizens, businesses and the public in general regarding the economy. News channels, conservative and liberal, are constantly bombarding us with negative news and asking us to worry about impending or possible disasters. If we base our decisions on the concept that something bad is just around the corner we will never get out of our recession. Our decisions must be supported by the facts.


The photoluminescent properties of dysprosium complex (ethylenediamine tetra acetate) were investigated in the presence of different sized Ag nanoparticles. The formation of nanoparticles aggregates and a new absorption band at longer wavelength region were observed upon the addition of Ag nanoparticles when the pH value of the complex solution was 4.0~6.0. With the increase of the concentration of Ag nanoparticles, the peak at long wavelength was red-shifted, at the same time, enhancement of the emission intensity for the complex solution containing Ag nanoparticles was observed. The enhanced fluorescence of the complex and the enhancement factors were dependent on the concentration and size of Ag nanoparticles. With increasing Ag nanoparticles concentration enhancement factor first increases and then decreases. The enhancement factor of small Ag nanoparticles is lower than that of large Ag nanoparticles, meanwhile, the enhancement factor of small Ag nanoparticles can reach the maximum in lower Ag amount condition. The enhancement effect was discussed in terms of the effects of nanoparticle aggregates, the local electromagnetic field enhancement effect and optical absorption due to surface plasmon resonance.


Myo-inositol was isolated from the water extracts of dried tea leaves. The method is as follows: neutral lead-acetate was added to the water extracts of dried tea, leaves, and after removing the salts the solution alkalized by dil. NaOH soln. in order to precipitate the lead-salts of myo-inositol and other glucosides. The basic lead-salt was next decomposed by hydrogensulphide gas and evaporated in vacuo to a thin syrup, then absolute methanol was added. The insoluble fraction, after the removal of methanol, was passed through the columns of ionexchange resin in order to remove cations and other acids. The solution, after passing through the two columns, were then evaporated in vacuo to a thin syrup and recrystallised from dill ethanol and methanol-ether solvent. The yield is about 0.01 wt. % of dried tea.


The relative importance of Total Factor Productivity (TFP) vis-à-vis factor accumulation for economic growth has occupied economists not least since Tinbergen (1942), Fabricant (1954), Abramovitz (1956) and Solow (1956). In this paper we build on an established strand of the literature that interprets TFP as successfully assimilated global technology (Parente and Prescott, 1994, 2002). What unites concepts such as 'absorptive capacity' and alternatives used to describe this setup – e.g. Abramovitz (1986) social capability – is the notion that despite the designation of technological knowledge as a public good or being in the public domain (Nelson, 1959; Arrow, 1962) technological catch-up and thus convergence in income per capita is by no means guaranteed, but requires considerable efforts and investments (Aghion and Jaravel, 2015).1


In this contribution, we present the data acquisition system system of the KM3NeT neutrino telescopes, ARCA and ORCA, already operating while under construction at the bottom of the Mediterranean Sea. The DAQ system implements a modular and scalable hardware-triggerless streaming readout of the optical modules in the telescopes. Handling a raw incoming throughput up to hundreds of Gbps, it is integrated with the online alert system of the KM3NeT Multimessenger program. The system will evolve according to a new design, currently under validation, which will grant the extension of the telescope to the aimed cubic kilometer scale.


The ability of Chinese Literature graduates needs to be evaluated, so that the organizers of the Chinese Literature study program continue to update the courses taught at college. The ability of graduates can be seen from the results of treasure studies and the soft skills needed can be mapped. So far, the curriculum, and graduate competencies focus more on hard skills even though soft skills are also needed in doing a job. Therefore, this research was conducted to map the soft skills needed to do a job. Data collection was carried out from the input of 99 Chinese Literature graduates spread across three universities that have Chinese Literature study programs. From the input of the graduates, communication skills and teamwork are more needed in doing a job. Thus, policy makers are expected to consider a soft skill course that is beneficial for students in doing a job.


Bo-Kun CHOI, Seoul (KR): An hod and a devi lated Dong-Hyun YEOM, Seongnam-si (KR) operation method and a device related to emergency S1tu ations are provided. A method for controlling an electronic (21) Appl. No.: 14/625,094 device includes determining a designated situation, based on at least one piece of information obtained from outside the (22) Filed: Feb. 18, 2015 electronic device and information obtained from at least one sensor of the electronic device, determining features corre (30) Foreign Application Priority Data sponding to the designated situation, and controlling the elec tronic device, based on at least one of the features and user Feb. 21, 2014 (KR) ........................ 10-2014-OO2O970 status information.


The This research is about the benefit of studying results management of the business boutique fashion as pioneering readiness of the business muslim women distro. The aim of this research of being to receive the data about the benefit of studying results management of the business boutique fashion was considered from competence and the aim of the business boutique fashion of the concept command, the etiquette of business fashion, the strategy of business boutique fashion, the management of human resources of business fashion, and the management production and marketing of the business boutique fashion. The method that was used in this research that is the descriptive method with the collector's implement of the data took the form of the poll. The sample of research used the purposive sample, that is the student of boutique concentration in Studi Program of fashion design Education Faculty of the Technology and Vocational Education, the generation of 2011 and 2011 that was total 34 people. Results of this research showed that more than half of students stated results of studying the management business of boutique fashion as being inspected from business boutique fashion of the concept command, the etiquette of business fashion, the strategy of business boutique fashion, the management of human resources of business fashion, and the management production and marketing of the business boutique fashion. Resume of this research showed that more than half of students experienced the benefit of studying results management of the business boutique fashion as pioneering readiness of the business muslim women distro


An improved method for speed regulation of motor is proposed.Firstly,a error threshold value is calculated by the given motor speed.Then the whole transition process of motor speed is separated into two continuous subsections by the threshold value.Different control are adopted in different domain.The subsection of rising time in the use of Fuzzy control,followed by the use of PID control.So a Fuzzy-PID composite controller is presented,which combines the advan-tages of Fuzzy controller and PID controller,and gets rid of the disadvantages of them.Taking the soccer robot motor as a plant to be controlled,the process of designing is discussed particularly and some experiments are done.The experimental results show that the control effect of Fuzzy-PID composite controller is superior in many performances to conventional PID controller.


The quality of frying oil has been linked to the quality of the finished product by a number of researchers. Although several methods of oil quality measurement have been proposed, measurement of oil viscosity has been selected since there are reports of increasing oil viscosity with oil abuse and because oil viscosity is a primary factor in heat and mass transfer occurring during frying. This paper will develop an analysis of an ultrasonic pulse-echo measurement system using the assumption of linear, time-invariant components. This analysis will lead to the development of a method of determining acoustic attenuation by measuring the amplitude of reflected acoustic signals from a plane interface. Experimental results will be presented which apply this method to the measurement of acoustic attenuation and impedance in samples of used corn oil. These values are compared with kinematic oil viscosity over a range of 40-120 mm 2 /s. Attenuation increased from 30 x 10 -9 to 70 x 10 -9 neper/cm Hz over this range of oil viscosity. Acoustic impedance increased from 1.315 x 10 6 to 1.340 x 106 Pa/m over the same range.


Flower-strips are increasingly recognized as mandatory elements in agricultural landscapes for pollinators to survive. In this study, we raised the hypothesis that flower-strip traits additionally affect biogeochemical cycling towards climate change mitigation. Therefore, we investigated soil carbon and nutrients stocks in paired comparison to adjacent land use and looked at water retention.

Two study farms of 50 ha in southern Germany were sampled once in spring, summer and autumn. The examined flower-strips of both farms were sown in 2011 and are in use since then. Pairwise sampling reduces the influence of the expected high variation in soil parameters. For each pair we sampled 3 depths: topsoil (0-5 cm), plow horizon (20-25 cm) and subsoil (30-35 cm). Different parameters of soil carbon, nitrogen, nutrients and water will be presented with a focus on clay bonded carbon.

Preliminary results indicate that flower-strips significantly increased nitrogen availability, soil carbon stocks and accordingly showed a trend to improve the water storage capacity in the plow horizon. We did not observe a statistically significant effect on nutrient availability.

Provided that these results will be confirmed, flower-strips traits could go beyond the important trait of giving pollinators a home in vast agricultural landscapes. By slightly increasing the amount of flower-strips in these landscapes, a significant increase in carbon sequestration and water retention will be achievable adding to the 4 per mille goal of the UN.


A method for estimating the actuation efficiency of a structurally integrated active material is presented. A background literature search revealed many different expressions for efficiency depending upon the application and discipline of interest. Following the review of the literature, an efficiency expression was developed for a piezoelectric actuator in the frequency domain. The actuation efficiency of the piezoceramic actuator was define as the ratio of total mechanical energy imparted to the structure to total electrical energy drawn by the piezoceramic from an electrical power source. The efficiency expression is a function of the piezo electromechanical coupling coefficient, the mechanical impedance ratio of the structural to the piezoceramic material, and the frequency of operation. The developed expression was then used to analytically predict the efficiency of a single degree-of- freedom system actuated by a piezoceramic actuator. Static and quasi-static efficiency results agree with analytical results found in the literature. Dynamic analysis of the efficiency expression, however, produced unexpected and interesting results. For the given definition of efficiency, there exists a combination of material parameters and drive frequency that yield efficiencies greater than one.Further analysis provided evidence that frequency domain formulation provides that while there are instances when relatively large quantities of mechanical energy in the system exist relative to the quantity of electrical energy being drawn by the actuator, total energy is always conserved. The important result of this work was the knowledge gained in the fundamental understanding of power, energy, and efficiency as it relates to dynamic actuation of an electromechanical system. The results shown here support the concept of actuation at or near a system resonance to increase efficiency. This work is on-going; the ultimate goal of which is to develop a tool for aiding active material actuation feasibility studies by using actuation efficiency as a performance metric.


The spin-dependent distribution functions of quarks and gluons in a proton are studied so as to explain the European Muon Collaboration {ital g}{sub 1}{sup {ital p}}({ital x}) data by introducing a new model, in which characteristics of both the static quark and the quark-parton model are taken into account. The {ital x} dependence of {ital g}{sub 1}{sup {ital p}}({ital x}) is reproduced well. It is shown that polarized gluons through the anomaly play a significant role and the resultant sum of quark spin is 0.375. Furthermore, {ital g}{sub 1}{sup {ital n}}({ital x}) as well as {ital g}{sub 1}{sup {ital p}}({ital x}) is predicted for future experiments.


Crystals of the title novel red disperse dye were grown by slow evaporation from a chloroform solution and the crystal structure was determined by single crystal X-ray diffraction analysis. The dye molecule crystallises in the triclinic space group P1 with the unit cell dimensions a = 7.561(2), b = 11.628(10) and c = 15.607(3) A. The diffraction analysis showed that the hetarylazo skeleton of the dye is nearly planar, with the ester groups oriented up and down the plane of the molecule thus imparting it a 'Y' shape structure. The intramolecular hydrogen bonds, together with van der Waals interactions, stabilise the molecular conformation and crystal packing.


This seminar will focus on the physics and astrophysics of ultra high energy cosmic rays (E > 1 EeV), with emphasis on the results reported by the Pierre Auger Collaboration and the interpretation of the experimental data. We will discuss the intriguing and apparent contradiction between the correlation of arrival directions of cosmic rays with astrophysical objects and observables related to the chemical composition of the primary particles. Neutrinos and photons of ultra high energy will also be discussed.


Gene replacement therapies (GRTs) are increasingly expected to reach the market. Current healthcare systems are struggling to fund such valuable, costly therapies. GRTs are highly valuable as they extend life through sustained, long-term efficacy or by saving on the costs of a current high-cost standard of care. Some payers have implemented payment models, which do not address the budget impact on the year of acquisition or administration of costly GRTs. This study aims to (1) introduce amortization as an accounting tool within the context of healthcare, specifically for GRTs, (2) present a systematic literature review (SLR) on the amortization or depreciation of pharmaceuticals and medical devices, (3) assess the rationale and feasibility as well as the pros and cons of the amortization of GRTs, and (4) provide recommendations for future steps for the introduction of amortization for GRTs. The limited literature, identified in the SLR, has proposed amortization as a solution for costly, highly valuable GRT funding, but did not fully investigate and detail amortization and its feasibility. This paper further details and illustrates amortization as a promising method for these GRTs by facilitating market and patient access. Current accounting principles and guidelines must evolve to apply amortization to GRTs.


(Abstract )This paper proposes an image steganographic algorithm based on direction coding in Discrete Cosine Transform(DCT) domain. The secret image is transformed by 8 × 8 block DCT and quantized by using JPEG standard quantification table, then the DCT coefficients are coding by the trip coding. And the cover image is transformed by 8 × 8 block DCT and quantized by using the improved quantification table, which raises the embedding capacity indirectly. The secret image data are embedded in the low frequency of the cover image's DCT coefficients by using the steganorgraphy algorithm based on direction coding. Experimental results prove that the steganorgraphic method has a great embedding capacity, makes the image containing secret image has a good visual effect, and it can resist to 2 χ analysis.


To expose the high school students to renewable energy, a project to build wind turbines exclusively by the high school students was conceived and implemented in a South Texas high school. A key motivation of the project was to make high school students interested in engineering by letting them build a complete system that harnesses wind power. The proposed system converts, stores, and measures all pertinent energy parameters for future usage. Twenty two students worked together as a team and shared all the engineering and budgetary responsibilities. An important societal component was added to the project by identifying the potential of small wind turbines to meet, at least partially, the energy need for isolated, off-grid poor residents in Colonias of South Texas. A challenge was made to the students; namely, how to supply electricity to poor residents in isolated, off-grid Colonias. They were asked to analyze the need, identify a solution, and finally, deliver it. Important major restrictions for the students included an easy to follow engineering build, $1500 dollar limit for the turbine parts, no outside help, and commercially available parts. None of the authors were involved in manufacturing the turbine. A total of 22 students, 14 boys and 8 girls, participated in this program. The team had a Team Leader, a girl, and four Team Captains. The team was trained by one of the authors on all science and engineering aspects of wind turbine. Another author trained them in blade carving and aerodynamics. One of the teachers from the high school kept a watchful eye for day to day activities of the students, mostly for safety reasons. Hugh Piggott's book on the subject was given to the students as a guideline. Final product was a 30' tall tower with three 8' diameter pine wood turbine and 12 Neodymium Iron Boron permanent magnets. The system also included 1200 Watt Whistler power inverter, Xantrex charge controller, and a DC heater as dump load. Four deep cycle Werker 6 VDC output batteries were used to store the wind power to deliver at 12 VDC when needed. Finally, the students also added a HOBO data logger to collect pertinent wind data. Estimated "sweat equity" for the system built was 150 person-hours, a doable effort for Colonia residents. While the turbine was not able to generate enough power for the lofty goal of electrifying a Colonia home, it was an excellent start for the students to be sensitive to local societal needs and the sense of achievement by developing and delivering an engineering solution to the problem. Students also learnt a lot of about renewable energy and many concerns of the local Colonia residents. Finally, it left a legacy of excitement and hope for the next group of students to further refine the solution. Twenty of the twenty two students, including two who changed their education path to engineering, joined science or engineering degree programs after graduation from this program. P ge 25464.2 High School Students Erecting Their Wind Turbine, Complete with Data Acquisition System


With the pandemic causing a sustained global economic downturn, the NPL market looks primed to swell in volume, increasing the NPL stock in place since the global financial crisis. Particularly across Europe, large stocks of NPLs pose risks to financial stability. Even with some NPLs now foreclosed, many associated real estate assets have yet to be cleared. This poses the risk of additional non-performing exposure. With loan furlough schemes and payment holiday schemes primed to end or be scaled back in most jurisdictions, NPLs are highly likely to surge. As responsible financial institutions, banks must act swiftly to remove these loans from their respective balance sheets as efficiently as possible.


Objective To obtain the information related to the populations of mosquitoes flies and fluctuation of the latter in Shanghai Jiangwan wetland.Methods Mosquitoes' adult collected by light-trap or larvae from breeding place and flies' adult by cage-trap or net.Results 6 species of mosquitoes and 60 species of flies were collected.First collection of flies is in March,it decreased and disappeared gradually in November.The peak period of flies is in September.Conclusion The population of mosquitoes and flies are abundant in Shanghai Jiangwan wetland.Coquillettidia ochracea is collected for the first time in Shanghai area;and the dominant species of flies in the wetland is Chrysomyia megacephala.


Volume 12, issue 5, e01192-21, 2021, https://doi.org/10.1128/mBio.01192-21. In Fig. 2B of the original paper, the image of the Western blot that shows the expression level of c15850 using anti-His monoclonal antibody was duplicated in the panel for c21220. This duplication issue happened at the figure assembly stage and was not identified at submission and proof stages. The authors provide here Fig. 2B with the correct Western blot image in the c21220 panel, which does not change results and conclusions of the article. Nonetheless, the authors apologize to the readers for any inconvenience that this error may have caused.


Background: Today, due to the important role the university students play in governance of the country, they are considered as one of the most important groups of the society. Thus, their health status should be monitored. Inappropriate status of dormitories can be a source of diseases and endanger the students' health. This study aimed to determine the health status of Shahid Dastgheib dormitory in Shiraz University of Medical Sciences. Methods: In this cross-sectional study, the researcher referred to all the rooms in Shahid Dastgheib Dormitory in Shiraz University of Medical Sciences and collected the necessary data for determining the health status of the rooms using the health assessment form. Then, the data were encoded, entered into the SPSS statistical software (v. 19), and analyzed using descriptive statistics, Chi-square, and Fisher exact test. Results: According to the results, 15.5%, 68.9%, 14.8%, and 0.8% of the rooms accommodated 1, 2, 3, and 4 individuals, respectively. Moreover, most of the dormitory students (36.1%) were from Fars province. In this study, a significant correlation was found between the number of occupants per room and the health status of that room (P<0.05); such a way that as the number of occupants per room increased, the room showed a weaker health condition. Overall, dental students having about 8% of the optimal health status, 21 and 23 year old age groups having approximately 4% of the optimal health status, post-graduate students, and older students had more desirable conditions compared to the students of other schools. Conclusion: Since the research was conducted in one dormitory, similar studies are recommended to be performed in all dormitories. Overall, the present study results indicated that the health conditions of the dormitory was not much desirable and requires more attention on the part of the authorities.


With the popularization of computers, mobile video, smart phones and other media terminals rapid development, traditional information media gradually been abandoned, they have failed to meet the rapidly changing information to outside people's curiosity, so people rely more and more accustomed network news media. Dissemination of news has undergone tremendous changes, people started to pay attention more on network news media. The media not only have the news media features: timely and accurate. Also has a large amount of information to facilitate the management, easy to read, etc. [.So for the current social situation, news publish and media must also adapt to the times, the news publish system use web application with information technology is a great deal of research on the social significance. Because with it, you can freely check news, quickly find their favorite news, and you can add your comments, but also make it more convenient for administrators clear management news and it can well improve the efficiency of the managers.


This work adopts a mobile social network in proximity (MSNP)–centric group touring service concept to share geo–points of interest's (POIs') data among mobile users belonging to the same touring group. In a group‐based touring service, a mobile user can create a group in the MSNP that can consist of some clusters in which some members having the 3G/3.5G/4G cellular network service are selected as cluster leaders to enable their Wi‐Fi hot spot functions as mobile proxies. After that, each group member can join one of the clusters by connecting with a cluster leader's Wi‐Fi hot spot. Thereafter, each cluster leader downloads geo‐POIs' data using 3G/3.5G/4G cellular network and then shares the downloaded POIs' data with its cluster members through its Wi‐Fi hot spot. This work proposed a handoff mechanism such that each mobile user can handoff from its currently connected cluster to the other one that belongs to the same MNSP group. The main handoff concern is that each handheld device only allows a limited number of handheld devices to connect with its Wi‐Fi hot spot at the same time. This work proposed a K‐member‐limited MSNP‐based INter Group handoff scheme called K‐MING to tackle the handoff problem. The performance analysis shows that K‐MING for the group touring scenario has better performance for the sharing of geo‐POIs' data downloading in terms of average power consumption and average downloaded data volume from 3G/3.5G/4G cellular network than that of the individual touring scenario.


Remaining useful life (RUL) prediction of lithium-ion batteries can reduce the risk of battery failure by predicting the end of life. In this paper, we propose novel RUL prediction techniques based on long short-term memory (LSTM). To estimate RUL even in the presence of capacity regeneration phenomenon, we consider multiple measurable data from battery management system such as voltage, current and temperature charging profiles whose patterns vary as aging. Unlike the traditional LSTM prediction that matches input layer with output layer as one-to-one structure, we leverage many-to-one structure to be flexible for various input types and to substantially reduce the number of parameters for better generalization. Using the NASA lithium-ion battery datasets, we verify the accuracy of the proposed LSTM-based RUL prediction. The experimental results show that the proposed single-channel LSTM model improves the mean absolute percentage error (MAPE) by 39.2% compared to the baseline LSTM model. Furthermore, the proposed multi-channel LSTM model significantly improves the MAPE, e.g., by 63.7% compared to the baseline; the proposed model achieves 0.47–1.88% of MAPE while the state-of-the-art baseline LSTM shows 0.6–6.45% of MAPE.


The research aimed to investigate the scope of special rural retirement to improve the living conditions of retirees and their families in the municipality of Nova Tebas PR, evaluating it as a mechanism for boosting local commerce. The research problems were: a) Does rural retirement promote improvements in living conditions? b) What are the main characteristics of retirees? c) Is rural retirement a factor in boosting the local economy and trade? As a methodology we adopted the survey and analysis of qualitative and quantitative data. Thus, we found some characteristics of most retirees: strong rootedness in the territory, owners of small areas of land, with little or no schooling. We found that 94.4% consider that there were positive changes in their life after retirement. We conclude that the benefit is essential for the dignity of elderly farmers, and it is essential to guarantee access.


China's distance education[1], has great development prospects ,based on the vast land area and a large population of Chinese, but there are still many deficiencies.The presence of existing distance education system has high hardware and software requirements and resource duplication. At the same time ,the distance education system expansion capacity is weak and Configurable is poor and so on. Processing power and unlimited storage capacity of cloud computing is an efficient. Resource integration can ensure the dynamic characteristics of resources, and enhance the advantages of resources. This paper presents the study of distance education system based on cloud computing and resource integration, which can integrate the information resources of teaching , improve resource utilization, but can also enhance the teaching level. And then provide a broad platform for the development of distance education.


This study aims to design a sales system in which there are customer complaints which apply Customer Relationship Management (CRM) relationship management, which helps customers make complaints at the Village Flower Shop, Data obtained in this system consists of, questionnaire data filled out by customers The method used in this system is SDLC with waterfall modeling. To illustrate the model of this system is the context diagram data flow and Data Flow Diagram (DFD), while the relation uses Entity Relationship Diagram (ERD). The system is designed based on Website, using the PHP programming language, MySQL as its database, qualitative research techniques, by collecting data and information descriptively, testing on this system uses a blackbox. With this research where it is expected that the Flower Flower shop with customers and also improving the quality of service quality to customers, to create customer satisfaction.


The insect growth regulator fenoxycarb reduced colony size indices of laboratory colonies of red imported fire ants, Solenopsis invicta Buren, by 93-98% within 8 wk after treatment. Reductions were caused by lethality to developing immatures, inhibition of egg production by the queen, and a shift in caste differentiation from worker to sexual forms. No significant difference was noted in the response of colonies to 5 or 10mg (AI) per colony; the majority of colonies treated at either dosage died as a result of the treatment. In field tests, baits containing fenoxycarb eliminated ca. 60% of the colonies on treated plots and reduced total ant population indices by 67-99% within 12-13 wk after treatment at rates of 6.2-22.6 g (AI)/ha.


Speed control cushions have been used by local highway authorities as traffic calming devices on roads where extensive use of standard speed control humps was considered unsuitable because the roads were used as bus routes or were designated access routes for emergency vehicles. This report gives details of vehicle noise and overall traffic noise surveys carried out in 1993 alongside different types of speed control cushions located in the City of York. The objective of the study were to compare maximum vehicle noise levels at, and between, different types and layouts of speed cushion and to assess the change in both vehicle and overall traffic noise levels following the introduction of the speed cushions. The report describes the experimental method used and gives a summary of the results obtained and the conclusions reached. (A)


Indonesian language learning can be related to the environment, the environment becomes one of the components that influence the learning process. This can be related to language. Language is a communication tool that humans can acquire from birth. Suardi (et al, 2019) said that the mastery of a language by a child begins with the acquisition of the first language which is often called the mother tongue. Dardjowidjojo (in Suardi et al, 2019) says that language acquisition is a language acquisition process that is carried out by children naturally when they learn their mother tongue. The acquisition of the first language is closely related to the social development of children and the formation of social identity. In line with that, Yogatama (in Suardi et al, 2019) says that learning the first language is one of the overall developments of children to become members of asociety.


I want to commend the authors of Assessing communication proficiency in higher education: Speaking labs offer possibilities for a thought-provoking survey and presentation of the issues surrounding communication centers and labs across the nation. Such centers and labs have existed for a number of years and were historically established to improve individual speaking skills usually in conjunction with public speaking courses. In recent years, the call for assessment of student learning in higher education has provided the impetus for developing new approaches to the creation of communication centers with more ambitious goals.


An informal workshop on the themes of hypotheticality, resilience, and option foreclosure was held in Laxenburg on 7 July 1975.

This Working Paper is meant to serve as an informal record of the workshop. It includes the following material:

-- PART I: Invitation and Outline for the Workshop

-- PART II: Rapporteur's Notes - H. Swain; Rapporteur's Notes - Wm. Clark

-- PART III: Notes on Certainty, Uncertainty, and the Unknown (proposal of definitions for the workshop)

-- PART IV: A bibliography of relevant documents.


The design of polarizers is similar to a band-passed filter with deturned spacers which are advantages to extending the band of polarization seperation and to reducing transmission ripple for the p-po1arisation component in the polarized band [1]. The real optical thicknesses of high and low index layers are integral number of quaterwaves of a specific wavelength, easing the production of polarizers. Topical film design is as follows: where n and m refer to the number of quarterwaves of the low index layer. The experimental transmittance of the polarizers for p-po1arized radiation has reached 97-98% and for s-polarized radiation 0.1-0.5%.


In the first part the authors recall the basic principles of 'radar holography' and high resolution electromagnetic radar imaging construction, and present a real measurement of canonical radar targets. Then they introduce in the second part, the concept of 'radar polarization target decomposition theorems' to separate the Mueller matrix in two parts which are related to a single averaged target and to a residue component. In the last part, they introduce a new polarimetric method of classification based on a neural network modelization, and show how it is possible to identify a scatterer from the knowledge of the four high resolution electromagnetic radar images. >


Language is a medium for expressing thoughts. Although denying direct observations, thinking process may be revealed tangibly through languages. All natural languages, sharing a number of common features, definitely display variations of syntactic structures and narrative process or directions due to different ways of thinking. Chinese and English, as two most influential languages spoken by human beings, reflect not only the linguistic differences in describing the same real world by Occidental and Oriental language families, therefore, it is possible to explore various thinking models, and it should prove to be of academic and social values in terms of study of Chinese and English cultures,and tremendous promotion of English learning efficiency.


We studied the effect of easy calculation on the activity of the pre-frontal cortex associated with the increase in memory and performance using functional near-infrared spectroscopy (fNIRS). This effect of easy calculation on brain activity was examined measuring cell blood flow during a verbal memory tasks performed by volunteers matched on demographic variables. Verbal fluency tasks were loaded before verbal memory tasks to get information of standard cerebral blood flow for each subject. As the easy calculation, addition and subtraction with an integer of one digit were selected. It was found a significant oxyhemoglobin concentration (oxyHb) as well as total oxyHb increased, followed by a stable deoxyhemoglobin concentration (Hb), in the pre-frontal cortex. An increased functional brain activity was also observed during performance of the easy calculation task. Therefore, the activated area of the pre-frontal cortex expanded with the easy calculation task during the verbal memory tasks.


Research of modern marketing strategies used by business in the Ukrainian market of goods and services, in the context of the process of digitalization is a topical issue. The article reveals and summarizes the components of successful marketing strategies and tools of modern marketing in Ukraine, which should be used by business in a changing environment and existing risks, taking into account the concept of social responsibility. A high-quality research method was applied on social Internet networks, an in-depth interview was conducted, including a survey of 30 key informants - representatives of small and medium enterprises. Key words: marketing strategy, marketing tools, Internet technologies, business entities, Internet marketing, marketing trends


bicarbonate concentration that would result in a blood pH above the normal range. In conclusion, abnormalities in acid–base balance are common in patients with ESRD on dialysis. Presently, in the usual hemodialysis patient, acid– base balance is assessed on the basis of a predialysis serum bicarbonate obtained midweek. The clinician should be aware of errors that can occur with determination of serum bicarbonate concentration and ensure measurements are done correctly. In addition, the clinician should understand that target values for predialysis serum bicarbonate have been established primarily based on observational studies and expert opinion. Finally, given the potential risks of a serum bicarbonate concentration above the normal range, careful consideration should be given to maintaining preand postdialysis values in the normal range. References


Shoot tips from Dianthus caryophyllus Linn cultivars 'YunLianDie',were successfully cryopreserved by vitrification method.Orthogonal design was used to analyze the effects of dominant parameters on survival rates of shoot tips,including sucrose concentration of preculture medium,duration of preculture,duration of loading and duration of exposure to PVS2.The result showed that the highest shoot tip survival rate was: preculture 1 days,0.5 mol/L sucrose,loading time 40 minutes,PVS2 treatment in 40 minutes,liquid nitrogen treated 1d and throwing in 40 ℃ water,the survival rate was up to 44.13 %.The regenerated plantlets showed no more difference than the normal plantlets in physiological and biochemical characters.This test set up successfully a cryopresevation by vitrification system technique for Dianthus caryophyllus Linn germplasm,which provided an effective way for long-lasting conservation in vitro of Dianthus caryophyllus Linn germplasm resources.


Maintaining assets integrity in oil and gas facility can be quite challenging with conventional ways, therefore a need has arisen for an inclusive efficient way to continuously monitor the critical assets within the plant. Khurais Producing Department (KhPD) in its journey to achieve Operational Excellence has adopted and implemented Asset Integrity Management System (AIMS) for all of its safety critical assets.
 The development of KhPD AIMS system has gone through different phases. Starting from identifying the safety critical assets based on approved risk studies and analysis, defining critical functions and performance requirements which the asset shall comply throughout its life cycle as well as linking the system with other inspection and maintenance programs i.e. Preventive Maintenance (PM), Risk Based Inspection (RBI). In addition, a program to continuously assess AIMS was also established to ensure identifying any gaps and highlight areas of improvements.
 In this paper, Author will shed light on KhPD experience and share challenges encountered during AIMS implementation by adapting several best practices that helped accelerating the implementation and further enhancing the system. Morover, this paper will share the systematic approach and best practices adopted to overcome the obstacles and challenges in implementing AIMS including the innovative solution of real time, online monitoring and integrated automated alert system as well as the best practice of handling Management of Change (MOC) requirements for critical assets.


Abstract In reinforced concrete construction, deflection control is an important performance criterion for its serviceability and sustainability. In this paper, a finite element model dedicated to the calculation of the overall stiffness of reinforced concrete beams is extended in order to take into account steel-concrete interface damage due to excessive live loading resulting from cover-controlled cracking. The effect of cover-controlled cracking is taken into account by implementing a damage variable to reduce the bond at the steel-concrete interface. In addition, a criterion for the initiation of cover-control cracks based on a peak value of the steel stress at the crack location is also defined.


In order to investigate drought indices used to identify the appropriate fertilizer treatments in forage corn, hybrid Maxima (Zea mays var maxima) separate experiments were conducted during 2011 and 2012 in Arak. The experiment was a split-split plot in a randomized complete block design with four replications. Irrigation treatments consisted of two irrigation levels (I0) and deficit irrigation (I1) as the main factor, Nitroxin in three levels: 0, 0.5 and 1 ml per 30 kg seed and nitrogen levels of 0, 125 and 250 kg per hectare, which was considered as a minor factor. The results shown that STI, GMP and MP most appropriate indicators was applied to determine the best fertilizer treatments, to achieve the highest production yield in both normal irrigation and stress conditions. The maximum yield under both traditional irrigation and drought conditions achieved of the treatment combination of 1 ml per 30 kg seed Nitroxin with 250 kg Nitrogen per hectare (No2N2), this treatment was selected as the most favorable treatment combination. * Corresponding Author: Alireza Dadiyan  firstname.lastname@example.com International Journal of Biosciences | IJB | ISSN: 2220-6655 (Print) 2222-5234 (Online) http://www.innspub.net Vol. 4, No. 3, p. 23-30, 2014


The article offers the analysis of the issues related to the social administration of professional management personnel training which have become particularly complicated over the past two decades. Social schemes, conditions and factors of management are shown to be closely interconnected with the characteristics of human capital as the basis for social, economic and cultural development of the contemporary society. World experience and Russian specificity in the sphere of human resource management specialists' training are analyzed.


Objective: To observe the renoprotective effect and mechanisms of berberine on a type 2 diabetes rat model.Methods: Wistar rats were randomly divided into normal control group,diabetic group and berberine- treated group. Rats were sacrificed 20 weeks later. We detected the kidney weight index,24 h urine protein,morphology study,inflammationand fibrosis markers,such as IκBα,TGF- β1,TβRI and Smad7. Results: Compared with normal rats,the diabetic rats showed higher kidney weight indexand 24 h urine protein,severe morphological changes; berberine treatment decreased kidney weight index and 24 h urine protein,alleviatedmorphological changes,suppressed the expression of TGF- β1,TβRI,meanwhile increased the expression of IκBα and Smad7. Conclusion: Berberine has renoprotectiveeffect on a type 2 diabetic rat model. The mechanism might suppressinflammation and fibrosis via upregulating expression of Smad7.


This paper argues that the expansion of Southeast Asian trade in the first half of the nineteenth century was based partly on the growth of intra-regional trade. Singapore played a significant role as a British free port in the connection between Western long-distance trade and intra-regional trade. According to my estimates, intra-regional trade centered on the British and Dutch colonies grew from the 1820s to 1852, with the focus shifting from Java to Singapore. As background to this growth, attention is drawn to the relaxation of Dutch protectionist tariffs imposed on British cotton goods imported via Singapore. Prompted by British diplomatic protests, tariff levels were reduced, and Singapore increased its exports of European cotton goods across the region. The importance of the distribution system for regional products in the rise of trade in Singapore is also discussed. As Southeast Asian products exported to the Asian market were traded through Singapore, local merchants such as the Chinese and Bugis often conducted transactions of those regional products in exchange for European cotton goods. Thus, the distribution system for regional products facilitated the influx of European cotton goods into the region via Singapore.


The most important consideration for a school district technology coordinator is the issue of accommodating growth of the computer network over time. In order for growth to be accomplished in an orderly fashion, coordinators need a cost-effective scheme by which networks can grow in an incremental fashion, acquiring new technology when it becomes affordable. That scheme is called scalability. Scalability refers to network growth both in terms of the number of users as well as new applications in need of more bandwidth. K-12 education is one of the great users of bandwidth. Throughout the brief history of educational computing, teachers and students have seen and used the potential of graphics, video, the Internet, homepage development and conferencing in the learning process. In many districts, teachers somehow manage to utilize all the bandwidth available to them -- and then look for more. "Network-based learning technologies have been slow to evolve due to the unusual nature of developing infrastructure services," wrote Professor R. William Maule, of the University of San Francisco. "However, advanced communications technologies can greatly enhance instructional programs and are necessary to support future workers in a highly competitive global economy." A scalable network brings the learning resources of the world into the workstations of individual students almost instantaneously, in accordance with the latest technology. If the district network designers have incorporated scalability in their thinking, they can deploy new bandwidth technology at the point at which it becomes affordable. They do not have to re-do or re-install that which they have already done. They do not have to retrain staff. Existing management systems can be maintained. The designers build incrementally and thus cost-effectively, because they know that they are on a coherent migration path. Scalability is an issue that should be discussed in as much detail as possible in a district's technology plan. This alerts the administration and board to budget resources for the future, and indicates to all teachers how and when they will receive the new allocations of technology. Switching Switching is key to scalability because it represents a dramatic upgrade from shared technology that relies on hubs and routers, to switched technology. In shared technology all end users share 10 Mbps of bandwidth. Shared technology is often a source of frustration for teachers: it may take minutes for students to get on the Net and/or to reach their assignments. In a K-12 setting, students often use the same programs at the same time, and this severely challenges a shared technology network. In switched technology, every end user receives dedicated 10 Mbps, or even 100 Mbps access. The difference between shared and switched networks for the end user is dramatic. Tasks can be accomplished much faster because of the increased dedicated bandwidth to the workstation. …


experimental study on anti-penetration of super-high-strength steel fiber reinforced concrete shows steel fiber reinforced RPC(reactive powder concrete) is one new material with high strength,ductility,crack resistance and good anti-repetitive hit performance.5% volume blend ratio of steel fiber with reactive powder concrete is obtained,which provide good references for the application of RPC.


By shifting the Raman effect into the near infrared, fluorescene, which obscures the weak Raman signals, can be virtually eliminated. This development made it possible to record Raman spectra of almost any sample from industry – of minerals, of food, and even of living tissues for medical diagnosis. Of special importance is the recent use of fiber optics for applications to production control and quality assurance. Nondestructive analysis of paintings, objects d'art, antiquities, and even of fossibles is now possible. Thus, Raman spectroscopy is now more powerful and more universally applicable than the complexentary infrared spectroscopy.


Summary A study was conducted to investigate the effect of partial rootzone drying (PRD) in comparison to conventional irrigation (CI) at both 0.8 and 0.4 crop evapotranspiration (ETc) on water relations, vegetative growth, yield, and fruit composition of mature Sauvignon blanc grapevines (Vitis vinifera L.) in the San Joaquin Valley of California, USA. Soil moisture decreased quickly on the dry side and was restored quickly on the wet side of PRD-treated vines after switching. There was no yield reduction while vegetative growth was reduced at 0.4 ETc. However, in contrast to published studies assuming and emphasizing the role of PRD, this study demonstrated that only an irrigation amount of 0.4 ETc reduced stomatal conductance, transpiration, pruning weight, number of lateral shoots, number of active growing points, and fruit titratable acidity (TA). It appears that the irrigation amount, not PRD, is the determining factor inducing water stress and reducing transpiration and vegetative growth. With vine water relations only occasionally affected and no improvement in vine performance and vine water use at the same irrigation amount, PRD is not recommended for winegrape production with Sauvignon blanc under similar climatic conditions and cultural practices as in this study. Commercial implementation of PRD as described in previous studies should not be recommended until PRD is proven advantageous over CI at the same irrigation amount.


To promote public hospital performance management reform,and to realize public hospital medical resources allocation and public welfare,the article researches the public hospital internal performance management,from the performance management approach to classification,evaluation factor,the performance evaluation index norm and each assessment index weight,performance salary distribution standard and calculation method and so on in order to construct correct performance appraisal allocation evaluation system,to motivate workers,and to improve the benefit.


Objective To explore the Clinical feasibility of Single-working pore in VATS for treatment spontaneous pneumothorax.Methods From September 2008 to December 2009,42 patients with spontaneous pneumothorax performed operation in VATS. The incision for operation was 1.5-2 cm at lateral position of the fourth rib of anterior axillary line,while the incision for observation located at lateral position of the sixth or seventh rib of middle axillary line.Results None of patients need converse to transit-assisted small incision in chest. operative time was 30-120 min, an average of 45 min.Intraoperative blood loss 10-200 mL,an average of 50 mL.4-6 d for hospitalization, an average of 4.5 d.Conclusion In accordance with the way of Single-working pore in VATS for treatment spontaneous pneumothorax, We minimize the trauma and ensure safety of operation.


This study explores the relationship between earnings quality and fair value accounting beyond market-based measures, financial industry-related settings, and US firms. It analyzes the effect of discretionary fair value measurement of investment properties and earnings distribution using a sample of 2,658 observations between 2006 and 2017 from real estate firms in 36 countries. The results indicate that applying the fair value model to investment properties subject to International Financial Reporting Standards (IFRS) increases earnings variability and decreases earnings smoothness. These links are found for a fair value model dummy and incrementally for investment property fair values. Managers do not seem to exploit their discretion in lower-level fair value measurements to smooth out further earnings fluctuations. Among fair value model appliers, earnings variability appears to further increase, and earnings smoothness appears to further decrease, in the case of strong investor protection and real estate sector-specific institutional governance.


In the county of Campos dos Goytacazes, north of the State of Rio de Janeiro, Brazil, there is a large production of red ceramic, mainly perforated bricks. A percentage of these bricks are damaged during processing and become production waste. The amount of ceramic wastes generated after the firing stage is estimated to be at least 850 ton per month. This work investigates the mixture of fired brick wastes, known as grog, with clay bodies to produce red ceramics. Grog originated from bricks produced at 500-600oC, was added up to 20 wt.%. Pressed bodies were fired at temperatures varying from 500 to 1100oC. Body samples were initially tested for plasticity. After firing, samples were then tested for linear shrinkage, water absorption and mechanical strength. The results have shown that grog addition improves the workability of the clay and 5 wt.% of grog does not damage the fired properties at all temperatures. These results indicate the possibility of recycling fired brick waste into the own red ceramic processing.


ABSTRACT Screen time is increasingly pervasive in children's lives and, despite shifts in screen usage, television remains pre-eminent, especially for young children. As such, viewing content merits investigation. The current study applied a novel coding scheme to assess the relative prominence of prosocial and antisocial content in 90 programmes watched by a sample of 180 British two-year-old children. As well as providing a framework for future use in television research, our study highlights the wide variance of prosociality in children's programming. Future directions for coding and research are discussed. IMPACT SUMMARY a. Prior State of Knowledge: Children's television content has been under scrutiny for decades. Studies involving researcher-chosen content have shown links between prosocial content and young children's prosocial behaviour, as well as between antisocial content and aggressive behaviour. b. Novel contributions: The current methodological brief outlines a novel coding scheme for investigating prosocial and antisocial content that young children view in their everyday lives, taking into account prosocial and antisocial behaviour, as well as format features of the television programmes. c. Practical implications: The current work can be utilized and adapted for research in diverse disciplines by investigators interested in how prosocial and antisocial content are associated with child behavioural outcomes.


Purpose: Conditions of poor oxygenation (hypoxia) are present in many human tumors, including cervix cancer, and are associated with increased risk of metastasis and poor prognosis. Hypoxia is a potent activator of the PERK/eIF2a signaling pathway, a component of the unfolded protein response (UPR) and an importantmediator of hypoxia tolerance and tumor growth. Here, the importance of this pathway in the metastasis of human cervix carcinoma was investigated. ExperimentalDesign:Amplification and expression of LAMP3, a UPRmetastasis-associated gene, was examined using FISH and immunofluorescence in a cohort of human cervix tumors from patients who had received oxygen needle electrode tumor oxygenation measurements. To evaluate the importance of this pathway in metastasis in vivo, we constructed a series of inducible cell lines to interfere with PERK signaling during hypoxia and used these in an orthotopic cervix cancer model of hypoxia-driven


The digital transformation fostered by the increasing leverage of artificial intelligence (AI) has been a critical influencing factor unleashing the next wave of enterprise business disruption. Marketing is one of the business streams witnessing this transformation on a very intense scale. Contemporary marketing has begun to experiment with modern, cutting-edge technologies, such as AI, deploying them in mainstream operations to ensure accelerated success. This article explores the use of AI in marketing as an emergent stream of research. Based on inferences from earlier studies, the study categorizes marketing into five distinct functional themes—integrated digital marketing, content marketing, experiential marketing, marketing operations, and market research—and 19 sub-functional themes (activity levers). Across the chosen themes and sub-themes, the study further dovetails into and identifies 170 featured use cases of the extant literature, where AI is leveraged by marketing in delivering superior quality outcomes and experiences. By way of a systematic literature review (SLR), the article evaluates 57 qualifying publications in the context of AI-powered marketing and qualitatively and quantitatively ranks them based on their coverage, impact, relevance, and contributed guidance, and elucidates the findings across various sectors, research contexts, and scenarios. The study discusses the practitioner and academic research implications and proposes a future research agenda to study the continuous transformation fostered by accelerated adoption of AI across the marketing landscape.