The invention discloses a method for coating the back faces and the side faces of chips with protection materials. The method includes the following operation steps in sequence that firstly, a first blue film is stuck to the back face of a chip board; secondly, the chip board is cut, wherein the chip board is cut into independent chips; thirdly, second blue films are stuck to the front faces of the independent chips; fourthly, the first blue film is taken off; fifthly, the back faces and the side faces of the independent chips are coated with the protection materials and solidified; sixthly, third blue films are stuck to the outer sides of the protection materials; seventhly, the second blue films on the front faces of the independent chips are taken off; eighthly, secondary cutting is performed on the chips coated with the protection materials; ninthly, the chips are taken out, and the independent chips with the back faces and the side faces coated with the protection materials are formed. The method has the advantages that multiple blue films are matched in use, it is ensured that the cut chips are still a whole, overall coating is conducted, labor is saved, labor hours are reduced, and the overall manufacturing cost of the chips is greatly reduced.


Background: Murine double minute 2 (MDM2), a potent negative regulator of p53, promotes tumorigenesis if dysregulated. MDM2 dysregulation occurs via different mechanisms, including MDM2 gene amplification, MDM2 overexpression, and loss of cyclin-dependent kinase inhibitor 2A (CDKN2A), which encodes the MDM2 regulator p14ARF. Combined inactivation of MDM2 and GATA3 in hormone receptor-positive (HR+) breast cancer is lethal to the cell. Pharmacologic inhibition of MDM2 is a rational therapeutic strategy for MDM2-dependent, TP53 wildtype (WT) tumors, including tumors with MDM2 amplification or CDKN2A loss, and GATA3-mutant HR+ breast cancers. We determined the frequency and associated characteristics of genetic alterations of MDM2-dependent breast cancers, and evaluated sensitivity of these tumors to the small-molecule MDM2 inhibitor milademetan (RAIN-32).
 Methods: Genomic data were obtained from three datasets: METABRIC; TCGA PanCancer Atlas, GDC v23.0 (April 2020); AACR Genie, v11. Among TP53 WT breast cancer samples from each dataset, the frequency of GATA3 frameshift mutations, MDM2 amplification (copy number [CN] ≥12), and CDKN2A homozygous loss was determined individually and as co-alterations. The antitumoral activity of milademetan was evaluated in a GATA3-mutant, TP53 WT HR+ breast cancer cell line (MCF7 GATA3 G336fs*17), a breast xenograft model (MCF7 GATA3 G335fs), and ex vivo in MDM2-amplified patient-derived breast cancer organoids (CTG-2810, ER+/PR+/HER2–, MDM2 CN 8).
 Results: Genetic alteration frequencies in TP53 WT breast cancers by dataset are shown in the Table. GATA3 frameshift mutations (7.3–11.7%), MDM2 amplification (0.3–1.1%), and CDKN2A loss (0.2–1.2%) occurred across breast tumors, but were found with highest frequencies in HR+ tumors. Co-alteration frequencies in TP53 WT breast cancers across the aforementioned datasets were < 1%: GATA3 mutations/MDM2 CN ≥12 (0.2–0.3%); GATA3 mutations/CDKN2A loss (0.1–0.2%); MDM2 CN ≥12/CDKN2A loss (0%). Mean MDM2 expression (log2 (TPM+1)) in HR+ breast cancers (TCGA) were: GATA3 mutations, 5.12; CDKN2A loss, 5.88; MDM2 CN ≥12, 8.13, TP53 WT without these alterations, 4.78; mutant TP53, 4.35. A GATA3-mutant ER+ breast cancer cell line was sensitive to milademetan in vitro (IC50 126 nM). Milademetan 100 mg/kg displayed antitumor activity in GATA3-mutant HR+ breast xenograft and PDX models (p< 0.05 vs. vehicle). Milademetan also displayed activity in MDM2-amplified HR+ breast cancer organoids (IC50 0.2 μM). In a phase I study (NCT01877382), a patient with heavily pretreated MDM2-amplified breast cancer (MDM2 CN 16.8) had tumor shrinkage (18.2%) and PFS of 7.3 months with milademetan (orally 260 mg 3/14 days).
 Conclusions: The frequency of genetic alterations potentially targetable by MDM2 inhibition among TP53 WT breast cancers (i.e., GATA3 mutations, MDM2 amplification, and CDKN2A loss) is greatest in the HR+ subset, and these genetic biomarkers are associated with higher MDM2 expression. Preclinical data show that the MDM2 inhibitor milademetan has antitumor activity in GATA3-mutant and MDM2-amplified HR+ breast cancers, and support the clinical evaluation of milademetan in these tumors. Two clinical trials of milademetan – MANTRA-2 (Phase 2 basket study in solid tumors with TP53 WT and MDM2 CN ≥12; NCT05012397) and MANTRA-4 (Phase 1 study of milademetan + atezolizumab in solid tumors with CDKN2A loss) – are enrolling patients or in planning.
 Table.
 Citation Format: Francois-Clement Bidard, Diana Bello Roufai, Arielle J. Medford, Vijaya Tirunagaru, Robert C. Doebele, Aditya Bardia. Genetic alterations in breast cancer associated with MDM2 dependency and sensitivity to the MDM2 inhibitor milademetan [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P6-10-10.


[Objective] To investigate the effects of sodium sulfite(Na2SO3)on mice sperm abnormalities and embryonic development to determine whether it is a reproductive toxin. [Methods]①Twenty-five mice were randomly divided into five groups(negative control, positive control and three experimental groups)with 5 mice per group. The positive control group was administrated intraperitoneally with cyclophosphamide at the dose of 20mg/kg, the experimental groups were administrated with Na2SO3 by gastric perfusion at low, medium and high dose respectively, the negative group was administered with saline by gastric perfusion, all administrations were once a day for 5 days successively. On the 35th day, all mice were killed and spermatozoa were obtained for observing the rate of sperm abnormalities.②Female and male mice were copulated by the ratio of 2:1 to collect pregnant mice. The pregnant mice were then divided randomly into four groups (control, low, medium and high dose). On the 6th day of gestation, the experimental groups were administrated with Na2SO3 by gastric perfusion at low, medium and high dose respectively, the negative group was administered with saline, once a day for 9 days successively. The body weight of the pregnant mice was recorded every 3 days.③On the last day before delivery, the fetuses were obtained for observing the number of living, dead and absorbed fetuses and also skeleton abnormality, organ abnormality, weight of body, and length of body and tail. [Results] Sperm abnormalities in experimental groups increased significantly (P 0.05) compared with control group; the body weight and tail length of fetuses and the maternal body weight decreased significantly (P 0.05). [Conclusion] Sodium sulfite has reproductive toxicity on mice.


In recent years, cross-border movements of students have increased significantly. However, international students are finding it challenging to cope with the requirements of independent learning in host institutions, especially while studying in developed western countries. This paper outlines the backgrounds and expectations of these students and the challenges they face in the new cultural and academic environment while dealing with independent learning requirements. It also deliberates on the emotional state of these transplanted students and their attitude towards host institutions and possible independent learning outcome with limited institutional support. The paper then introduces a framework to better understand the nature of independent learning and the manner in which it impacts on the overall learning experience of international students.


Response to first comment. In the second paragraph of our abstract we explicitly listed over half of the approximately 50 metrics that we considered in our study. In the last paragraph we wanted to say what we did with those metrics (examined period-to-period changes) and provide at least one example of an important finding that could be articulated with minimal verbiage. I can't say that our choice is the most important finding


A 42-year-old man was admitted with acute headache, dysphasia, and severe hypertension. CT showed a left temporal hemorrhage. Seven-tesla MRI showed widespread leukoencephalopathy and over 100 microbleeds of earlier date. T2*-weighted images with short echo time, used for noncontrast enhanced magnetic resonance angiography,1 revealed a direct relation between some microbleeds and a small penetrating artery in a single scan acquisition (figures 1 and 2). Our diagnosis was hypertensive cerebral hemorrhage. Antihypertensive treatment was initiated. He recovered completely. The spatial relation between the microbleeds and the artery remained on repeated 7-T MRI after 6 months. The leukoencephalopathy had largely resolved. Owing to its high sensitivity to susceptibility effects, 7-T MRI now demonstrates noninvasively that hypertensive hemorrhages may emerge from the penetrating arteries.


A series of new aromatic poly(amide-imide)s were synthesized by the tri- phenyl phosphite-activated polycondensation of the diimide-diacid, 1,4-bis(trimelliti- mido)-2,5-dichlorobenzene (I), with various aromatic diamines in a medium consisting of N-methyl-2-pyrrolidone (NMP), pyridine, and calcium chloride. The poly(amide- imide)s had inherent viscosities of 0.88 -1.27 dL g 21 . The diimide-diacid monomer (I) was prepared from 2,5-dichloro-p-phenylenediamine with trimellitic anhydride. All the resulting polymers were amorphous and were readily soluble in a variety of organic solvents, including NMP and N,N-dimethylacetamide. Transparent, flexible, and tough films of these polymers could be cast from N,N-dimethylacetamide or NMP solutions. Cast films had tensile strengths ranging from 92 to 127 MPa, elongations at break from 4 to 24%, and initial moduli from 2.59 to 3.65 GPa. The glass transition temperatures of these polymers were in the range of 256°-317°C, and the 10% weight loss tempera- tures were above 430°C in nitrogen. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 73: 271-278, 1999


The aim of this work is to develop a method for increasing the security of information based on the analysis of keyboard hand typing. The paper considers a function that takes into account the minimum and maximum limits of biometric characteristics and the dependence of the stability of keyboard typing on its stability. As a result, a deviation factor is introduced to determine how much the biometric characteristic of the user after normalization will vary from the average value, which in its turn allows to determine the percentage of authenticity of the computer information system user. As a result, the probability of occurrence of errors of the first and second kind is reduced in comparison with the existing methods of authentication.


Mobile Edge Computing (MEC) is one of the most promising paradigms for overcoming Edge Devices (EDs) constraints. These EDs suffer from resource limitations in terms of power and computation.MEC will be more prevalent with the rising resource- intensive and time-sensitive EDs applications. MEC is considered a superior alternative to cloud computing. Despite computational offloading to the cloud offeringsignificant benefits related to computing and storage, EDs are geographically distant from the cloud, leading to significant transmission delays. However, offloading to the nearest server and ignoring the huge capabilities of the cloud is not always a good option. In contrast, local computing is rarely preferable. On the other hand, sometimes offloading to the nearest server is impossible, because of the current state of the server. These possibilities, as well as MEC system unpredictability, make the offloading decision difficult and critical. Therefore, the idea of the proposed model is based on Reinforcement Learning (RL). Moreover, the model is designed to make an optimal decision amongthe three offloading options; nearest edge server, best edge server, and cloud. The edge server can decide to offload tasks to the optimal available edge server or cloud directly, which depends on several parameters for reducing execution time and energy consumption. In addition, the edge server connects to all componentswithin its region, which improve the managing of resource allocation. This proposed model is expected to be optimal in edge servers connection and intelligent offloading decisions.


Ground fault currents that flow in the disturbance area and in the switchyard area of theSubstation create tension on the ground which can result in touch voltage and step voltage thatexceed the allowable limits of human safety. The thickness of the coral rock affects the value ofthe touch voltage and step voltage. This research was conducted to determine the effect of thethickness of the coral rock on clay and sandy soil on stepvvoltage anddtouchvvoltage.Themethod used is by measuring coral, clay soils and sandy soils, then calculating thevvalueofttouch voltageaand stepvvoltage based on the thickness of the coral used. The results ofcalculations and analysis of several thicknesses of coral stones used in clay soil, obtained theresults of the touch voltage in the dry state of 153.5615 volts and in the wet state of 152.0702volts, the results of the step voltage in the dry state 188.5057 volts and in the w et state 182 ,8265 volts. On sandy soil, the results of the touch voltage are 153.6893 volts in dry conditionand 152.1981 volts in wet conditions, the results of the step voltage in dry conditions are189.141 volts and in wet conditions 183.4349 volts.


The reductor of the coal handling system is connected with transmission shaft through hydraulic coupling in Mawan General Power Plant of Shenzhen Energy Group.The hydraulic coupling often needs to be removed from the transmission shaft during overhaul.The dismantling screw provided by the manufacturer often fails because of screw thread damage in use.Upon analysis of the screw thread damage on the dismantling screw,new dismounting kit and hollow screw have been designed and made by the plant independently and the application results are satisfying.


Here we report the synthesis and discovery of superconductivity in a novel ternary iridium–arsenide compound BaIr2As2. The polycrystalline BaIr2As2 sample was first synthesized by a high temperature and high pressure method. Crystal structural analysis indicates that BaIr2As2 crystallizes in the ThCr2Si2-type layered tetragonal structure with space group I4/mmm (No. 139), and the lattice parameters were refined to be a = 4.052(9) Å and c = 12.787(8) Å. By the electrical resistivity and magnetic susceptibility measurements we found type-II superconductivity in the new BaIr2As2 compound with a Tc (critical temperature) of 2.45 K, and an upper critical field μ0Hc2(0) about 0.2 T. Low temperature specific heat measurements gave a Debye temperature of about 202 K and a distinct specific jump with ΔCe/γTc = 1.36, which is close to the value of BCS weak coupling limit and confirms the bulk superconductivity in this new BaIr2As2 compound.


An efficient communication structure based on a finite projective plane with a duality is presented. The communication structure halves the number messages required in two rounds as compared to a communication structure based on a finite projective plane. It is shown that a finite projective plane with a duality can be constructed from a difference set, and that the communication structure presented has two kinds of symmetry.<<ETX>>


Background and objectives: Acrylamide has become one of the important public health concerns as it was detected in widely consumed food items; for example, fried bread, potato chips, any carbohydrate-rich food products cooked at high temperatures, roasted coffee. Several health hazards were reported after acrylamide exposure in animal and human models. Many studies reported that acrylamide can induce toxicity to many body organs such as reproductive toxicity, genotoxicity and neurotoxicity. Materials and methods: Forty adult male albino rats were randomly divided into 2 groups (n=10 per group). The control group (group I): received only standard diet and drinking water for 6 weeks. The acrylamide group (group II): received acrylamide via in tragastric gavage route at dose of 20 mg/kg once daily for 6 weeks. Histological and examination of the liver and kidney was done. Results: There were marked structural changes in kidney and liver of group II in the form of congestion apoptosis and vacuolations if compared to the control group. Conclusion: Administration of acrylamide continuously for six weeks causes massive destruction in both liver and kidney.


This presentation aims at providing responses to the following questions:i. What are the characteristics of the situation in the North-Eastern States of Nigeria? A mere situation of internal disturbances and tensions or a civil war (i.e. non-international armed conflict) or is counter-terrorism/ counter-insurgency not a complex form of warfare?ii. In which contexts are acts of terrorism prohibited by law (both international and national laws) for human rights protection?iii. Whose human rights are the law's concern?iv. What human rights obligations exist with regards to counter-terrorism measures?v. Whose obligations and responsibility are in reference here?vi. Why must a counter-terrorism operation/strategy be based on the rule of law and human rights?


Moral frustration is a form of psychological frustration of an altruist who meets with the recipient's negative or hostile response.The most common phenomenon is that kindness meets with grudge and helping others results in unhappiness.From the perspective of moral frustration,the article advocates the establishment of moral examples,the reconstruction of moral evaluation mechanism,the promotion of moral preference,and the readiness to help others so as to propose important behavior choices to the educated.


Based on the qualitative analysis of current situations of inclusive financial concentrated karst desertifi-cation extreme poverty areas of Guangxi,the paper uses variation coefficient method to evaluate the development ofvarious counties(districts)inclusive financial within the area. The results show that the development of inclusive fi-nance is in the low level. Finally,the paper puts forward"build five systems"to push the area financial development.


Traumatic atlanto-axial dislocation is an uncommon injury with high mortality. Blunt vertebral artery transection is also rare and is universally fatal. We report the clinical and radiographic findings of a case of traumatic atlanto-axial dislocation with bilateral vertebral artery transection, an injury rarely seen in the hospital. We also review the literature on the incidence and association of these injuries with emphasis on difficulty in diagnosis and need for a high index of suspicion to allow for attempts at intervention to prevent permanent neurologic damage. A 20 year old male was struck by a car and presented to our level I trauma center. Following initial resuscitation, he underwent neck CT angiography which revealed the injuries. These findings are incompatible with life and care was withdrawn shortly after the diagnosis was made.


Field trials of thirty-one herbicides applied to rape at pre-emerge or post-emerge were conducted for their safety during 1997-2000. The results showed that some of herbicides, such as quinofop-p-ethyl, sethoxydim, clethodim and fenoxaprop-p-ethyl, were safe to rape when the dosages were normal or double. Some of herbicides were safe to rape at lower dosage, such as acetochlor, metolachlor, propisochlor, although they could injury rape by using the double dosage. Flumiclorac-pentyl, clomazone, pendimethalin, trifluralin could cause injury to rape at normal dosage, but the rape could restore growth normally. Twenty herbicides were unsuitable with seriuos injury or plant decease.


In this paper we develop an identification algorithm to obtain an estimation of the prior distribution in the classical problem of Bayesian inference. We consider the Empirical Bayes approach to obtain the prior distribution approximation by a finite Gaussian mixture. An Expectation-Maximization based algorithm is used to obtain an estimate of the Gaussian mixture parameters. Our approach shows a good approximation of the prior distribution when the number of experiments is increased. We illustrate the estimation performance of our proposal with numerical simulations.


Introduction: Iinflammatory bowel disease (IBD) comprises a group of chronic immune disorders of unknownetiology characterized by intestinal inflammation which subsequently leads to debilitating symptoms whichcan adversely affect performance and quality of life. Crohn's disease (CD) and ulcerative colitis (UC) arethe two most common phenotypes.Patients and method: The cross-sectional study with the diagnosis of either Crohn's disease or ulcerativecolitis. The data collection was carried out from 25 september to 10 november 2020. From gastroinestinaltract and liver center ,Baghdad . Convienant sample are willing to participate. By questionnaire.Bodyweight and hieght was measured. Body mass index (BMI) was calculated . Recorded intake of all food anddrinks during last 24 hours. By Excil caculation program , the enegy intake of one day was calculated bymifflin-St.jeor method .The my pyramid plan for daily food and calories intake as recommended pattrern. Statitcal analysis were performed using SPSS 23 . Data described as mean±standerd deviation (SD).Datawere checked for normal distribution using t -test or chi square .The level of significance in the study wasp < 0.05 .Result: All the participants (55;100%) were low milk group servings intake( P<0.001), also( 74.5% ) ofparticipants were low fruit group servings intake (P<0.001) ,(92.7% ) 0f participants was low vegetablesgroup servings intake (P<0.001) , but ( 87.3% )Of participants were high grain group servings intake(P<0.001) ,( 65.5% ) of participaints was low protein group servings (P=0.041) , the fat group servingintake is low among (90.9%) of participants (P<0.001) , 52.7% of participants low energy intake. The meanBMI for both genders was in the normal range (23.16 ± 5.33) as (49.1%) of participants , only 14.5 % wasunderweight , 29.1% was overweight and 7.3% was obese. The participants live in aurban area as (89.1%) .The ocupation of them were 25% housewife,student (23.6%),employers (16.4%) and the rest with differentoccupations. The education of participants were primary school (36.4%) ,intermediate school(12.7%) ,secondry school were (14.5%), graduated were (12.7%) and the rest in the different educations. Unbalncediet shows among 76.4% of participants .Conclusions and Recommendations : all participant modified their diet,half of the participants had lowenergy intake and some of the participants had underweight .Emphasized the importance for patients to beprovided with nutrition – related knowledge as a part of strategies to avoid nutritional inadeqancies


We consider modifications of the standard nonlinear QCD evolution in an attempt to account for some of the missing ingredients discussed recently, such as correlations, discreteness in gluon emission and Pomeron loops. The evolution is numerically performed using the Balitsky-Kovchegov equation on individual configurations defined by a given initial value of the saturation scale, for reduced rapidities y=({alpha}{sub s}N{sub c}/{pi})Y<10. We consider the effects of averaging over configurations as a way to implement correlations, using three types of Gaussian averaging around a mean saturation scale. Further, we heuristically mimic discreteness in gluon emission by considering a modified evolution in which the tails of the gluon distributions are cut off. The approach to scaling and the behavior of the saturation scale with rapidity in these modified evolutions are studied and compared with the standard mean-field results. For the large but finite values of rapidity explored, no strong quantitative difference in scaling for transverse momenta around the saturation scale is observed. At larger transverse momenta, the influence of the modifications in the evolution seems most noticeable in the first steps of the evolution. No influence on the rapidity behavior of the saturation scale due to the averaging procedure is found. In themore » cutoff evolution the rapidity evolution of the saturation scale is slowed down and strongly depends on the value of the cutoff. Our results stress the need to go beyond simple modifications of evolution by developing proper theoretical tools that implement such recently discussed ingredients.« less


Section 8 of the Metropolitan Municipality legislation Act 5216 has rendered the Metropolitan Municipality to be responsible in undertaking the responsibilities in coordination of the infrastructure services. this task has touched upon how the Infrastructure Integration which has been applied since 2007 under the City of Konya Information System and how the current CBS database is necessary and indispensable for the integration to successfully function.


Aims To estimate the prevalence of Metabolic Syndrome (MS), its components and associated factors in adults aged 40 years or older. Methods Cross-sectional population-based study, with 1180 residents in a Southern Brazilian medium-sized municipality. We conducted household interviews, anthropometric measurements and laboratory tests. MS was defined according to the harmonized criteria of 2009. Sociodemographic, behavioral variables, and health services utilization were analyzed. The tests used were Chi-square, Fisher's exact test and the Wald test in the analysis of multiple factors by Poisson regression. Results Among the respondents, 959 (81.3%) performed laboratory tests and anthropometric measures. The prevalence of MS was 53.7% higher in women and in older ages. The presence of five MS components was observed in 12.0% (women – 15.8%, men – 7.3%). Age was the only variable associated with MS after adjustments. Conclusion The high prevalence of MS and its components, different in each sex and age group, indicates the need for coping with collective action approaches and establishment of individual therapeutic goals.


Abstract The effect of methylprednisolone (MP) on neurologic recovery and spinal cord blood flow (SCBF) was investigated up to 4 days after a spinal cord compression injury in rats. The injury was produced at midthoracic level by applying a load of 35 g on a 2.2 × 5.0 mm compression plate for 5 min, which resulted in transient paraparesis. MP was given as a bolus dose of 30 mg/kg i.v. 60 min after injury (n = 20) and controls were given saline (n = 10). The motor performance was assessed daily as the capacity angle on the inclined plane and SCBF was measured by 14C‐iodoantipyrine autoradiography on Days 1 or 4. On Day 1 the capacity angle was reduced from about 63° preoperatively to 33 ± 2° (mean ± SEM) in the control group and to 50 ± 1° in the group treated with MP (p < 0.05). Thereafter there was a slight improvement in both groups, but the difference persisted throughout the observation period. On Day 4 both gray and white matter SCBF was better preserved in MP‐treated animals than in the control group (59 ± 4 versus 49 ± 3 ml/min/100 g tissue for gray matter and 13.6 ± 0.6 versus 10.7 ± 0.8 ml/min/100 g tissue for white matter). Post‐traumatic treatment with MP, thus, improved both the neurologic recovery during the first 4 days and SCBF as measured on Day 4. It is speculated that the effect of MP is at least partly exerted on the vascular bed.


In this paper, novel absorption photometry microchip with no reference solution is presented for the first time. The microchip solves the problem about reference solution. The novel microchip, which uses no reference solution, has sensors with three different optical path lengths. The microchip was fabricated using some MEMS process technique, for example silicon anisotropic etching with surfactant added TMAH solution to form 45-degree mirrors. Fabricated microchip was characterized with blood sample, and property of absorption photometry with no reference solution by combining plural optical path was investigated. By proposed method, absorption photometry microchip which is compatible in performance and convenience succeeded in development.


Computer systems are becoming more and more complex and need to provide an ever increasing number of non-functional properties, such as reliability, availability, security, etc.. Such non-functional properties are usually provided to a system by general mechanisms called middleware. They are thus called, to illustrate that they are supposed to be used between the hardware (and operating system) and the application software levels, masking therefore the differences of the particular underlying system and allowing applications to be used with different underlying infrastructures. However, as the need for more non-functional properties increases, system architects are soon faced with the case where there is no available middleware that will provide all the required non-functional properties. Then, they either have to develop the needed middleware infrastructure from scratch or try to reuse multiple existing middleware infrastructures, where each one provides some of the required properties. In this thesis, we present a method for automatically composing middleware architectures, in order to obtain an architecture which provides certain properties. To arrive at the automation of composition, we first show how one can reformulate this problem into a model-checking problem. This reformulation gives a formal definition to the composition problem and allows us to reuse the methods and tools which have been developed for model-checking. Then, we present subsequent refinements to our basic method, used for avoiding the state-explosion problem for architectures of a larger size. To avoid stateexplosion, we show how it is possible to retrieve the structural information, present in the initial middleware architectures we wish to compose, and exploit it for constraining the search-space we have to investigate. Additional information present in the initial architectures constrains even further the search-space, thus allowing us to obtain a method for composing middleware architectures which can be used in practise. In this way, we facilitate the systematic study and analysis of the different compositions and provide a method for constructing quality systems.


Crowdsourcing can be a low cost means of collecting labels, but recovering the true labels from noisy crowdsourced labels is difficult task. Fortunately, recent work has given a provably optimal algorithm for solving this problem. In a 2014 paper titled "Spectral Methods meet EM: A Provably Optimal Method for Crowdsourcing" [5], authors Zhang et al. present a two-stage algorithm to recover the true labels and show that it achieves the optimal convergence rate up to a logarithmic factor. I will summarize their algorithm as well as their theoretical and empirical results here.


A critical study of sporoderm pattern under SEM in nine taxa of genus Bryum , growing in various bryogeographical regions of India, has been carried out. Of these nine taxa, microdetails of sporoderm pattern of six taxa: B. billardieri , B. caespiticium , B. capillare , B. dichotomum , B. pseudotriquetrum var. subrotundum and B. uliginosum are provided for the first time.


In this article, the state estimation problem is investigated for genetic regulatory networks (GRNs) with parameter uncertainties and stochastic disturbances. To account for the unavoidable modelling errors and parameter fluctuations, the network parameters are assumed to be time-varying but norm-bounded. Furthermore, scalar multiplicative white noises are introduced into both the translation process and the feedback regulation process in order to reflect the inherent intracellular and extracellular noise perturbations. The purpose of the addressed problem is to design a linear state estimator that can estimate the true concentration of the mRNA and the protein of the uncertain GRNs. By resorting to the Lyapunov–Krasovskii functional method combined with the linear matrix inequality (LMI) technique, sufficient conditions are first established for ensuring the stochastic stability of the dynamics of the estimation error, and the estimator gains are then designed in terms of the solutions to some LMIs that can be easily solved by using the standard numerical software. A three-node GRN is presented to show the effectiveness of the proposed design procedures.


Kent's controversial Control Unit has now been absorbed into a new Medway Centre with a revised programme, following a working party review of its function and effect. The authors gauge what impact it has had on county practice and identify concern about aspects of the new regime, but reach an optimistic view of progress achieved.


Notwithstanding all the advances of civilization and intelligence, and the increasing temperance agitation, and effort, the drink evil, or inebriety, is one of the most threatening ominous perils to all social progress and development of to-day. Some idea of its extent may be obtained from the following statistics. In 1890 over half a million persons were arrested in this country charged with being drunk and disorderly, crazed from the effects of alcohol. Nearly twenty per cent, had committed crime of petty character while under the influence of spirits. These facts furnish some approximate estimate of the extent of inebriety in this country. It is reasonable to infer that if half a million inebriates have come under police surveillance in one year, at least a third of this number using alcohol to excess, have escaped legal notice. The statement that there are fully a million persons in this country who are,


author is a close friend of Kreisler, and Mr. Lochner frequently permits the great violinist to tell his life-story himself. The second reason is that Fritz Kreisler has been portrayed as he is-a great universal spirit. For he is as familiar with languages, science, literature and politics as he is with the intricate scores of Beethoven's Violin Sonatas or the tricky fingerings of Paganini's Etudes. He is a man who has held his own "not only among artists and musicians, but also among kings and presidents, statesmen and philosophers, without ever losing his compassion for and understanding of the underprivileged and suffering." Kenneth Pool


We used a biotinylated antibody ELISA technique to measure plasma levels of lactoferrin (LF) and the LF content of peripheral blood PMN in 20 patients with psoriasis, 21, with eczema or other inflammatory skin conditions, 19 patients with malignant skin tumours and 20 healthy control individuals.


Legislation: Regulation 6/2002 on Community designs art.3(3)(e) Directive 98/71 on the legal protection of designs art.7(1) Cases: Dyson Ltd v Vax Ltd [2010] EWHC 1923 (Pat); [2011] Bus. L.R. 232 (Ch D (Patents Ct)) Lego Juris A/S v Office for Harmonisation in the Internal Market (Trade Marks and Designs) (OHIM) (C-48/09 P) Unreported September 14, 2010 (ECJ) *E.I.P.R. 60 In Lego, the Court of Justice of the European Union denied registration for an exclusively functional shape mark despite the availability of other shapes capable of fulfilling the same function and in Dyson v Vax Mr Justice Arnold established that a design can not be registered for a purely functional shape even though another shape could fulfil the same required function.


Theimprovement of the teacher's quality, including teachers in general and preschool teachers in particular, hasgained interested in many countries around the world. Currently, most countries in the world have issued a framework of competency or professional standards for teachers as a basis for preschool teachers to self-assess and be assessed for their qualities and competenciet. On that basis, preschool teachers can implement the plan of quality training, strengthen and improve professional expertise. This article, the author conducts research to evaluate the implementation of the professional standards manual of schools and the teacher's understanding of professional standards. This is considered an important factor that will contribute to improving the effectiveness of teacher ratings according to professional standards. In this study, the author uses mainly quantitative research methods (survey, descriptive statistics and inference statistics) to clarify the problems that the research has posed. Research results show that there is a relationship between standard manual training and preschool teachers' understanding of professional standards. Standards instructors have a good understanding of professional standards. Especially the training is organized by the school and the education and training department, so the training classes are small, with a small number of participants and therefore higher quality.


Port cities are distinguished from other cities by their waterfronts, which were shaped by economic and cultural transactions between each city and its networks. Trade-related activities prepared the conditions for accelerated globalisation with economic changes. The Ottoman Empire supported commerce and production in Western Anatolia after 16th century. Many European merchants thus moved to Izmir in accord with an agreement made by the Ottoman Empire in order to maintain commercial events. Afterwards, the city developed as a culturally diverse entity due to its port activity. The waterfront and arguably the whole structure of the city have been influenced by cross cultural exchanges. Study explains how shifting networks have created a unique palimpsest of structures and actor networks between 16th and 21st century in Izmir, a port city on western coast in Turkey. This paper explores the transformation of Izmir's urban form and identity. Different architectural practices such as Dutch, British, French, Italian, Greek were concretised on Izmir's waterfront and have become a part of the city's identity. Nevertheless, political decisions, governmental policies, fires, earthquakes, planned and unplanned events changed the waterfront and caused gaps in history told by its built environment. This study analyses the vicissitudes in the planning history of Izmir's waterfront.


After a chapter on various types of cucullati—seated, grotesque, dwarfish, comic, Silenus-like, and phallic, D. turns to hooded figures in funerary contexts and to hooded children. In the funerary chapter, processional scenes on Etruscan ash-chests of the Hellenistic period provide the most impressive material. As we have seen, hooded genii are, inter alia, deities of death. But it is obvious that in the sphere of death a hooded cloak befits all parties on the purely human level—the deceased, the mourners, and attendants at the funerary rites. Need we assume, with D., that the hooded figures, whether adult or juvenile, that are shown accompanying burial-corteges are superhuman genii, rather than human survivors and servitors ? The axe, hammer, or mallet, that these figures occasionally carry, could be borne by ordinary mortals as ceremonial implements or as emblems of death, since such objects are often the attributes of those winged demons, the true Etruscan genii of death, who sometimes appear, in ash-chest reliefs and elsewhere, in the escort of the departed. In his fourth and fifth chapters D. sums up the general characteristics of ancient cucullati and reviews the evidence for their survival into post-classical times. D.'s work affords a very valuable collection of important material, lucidly analysed and critically presented. To this collection a few additions (other than those already mentioned) suggest themselves. There is, for instance, a terra-cotta genius cucullatus in the Palatine Museum, found in the temple of Cybele ; and another terra-cotta figure, with hood thrown back on to the shoulders, at Ostia. There is also the as yet unpublished series of mainly phallic terra-cotta cucullati from the Athenian Agora. These range in date from the second to the fourth century of our era, and a number of them may have been imported into the city by foreign mercenaries and other immigrants. The obvious defects of D.'s brochure are its unfortunate lack of an index and the inadequacy of its line-drawn illustrations. Some of the monuments surely deserve good photographs.


It briefly introduces the construction method for the main works of thin wall large cylinder breakwater engineering and summarizes some construction experience and matters needing attentions.


1. Register and politeness 2. Words 3. Grammar and verbal strategies 4. Language and everyday life Japanese index English index References.


In this paper,we adopt M-matrix and a-diagonally dominant matrix,for 0≤α≤1,using Holder inequality and give some criteria for generalized strictly diagonally dominant matrix.Thus some recent given results are improved and generalized.New criteria's advantages are illustrated by some numerical examples.


In an effort to help practitioners with the daunting task of evaluating risk potential in their patients (a misdiagnosis can very well mean death), Dr. Thomas White, a clinical psychologist with over 35 years of...


Suicidality expresses mental pain and can symbolize a desire to change the everyday life situation. Persons with suicidality live with ambivalence and oscillate between life and death. Persons with suicidality can be motivated to continue living by the use of person-centered care. Through application of The Tidal Model, the nurse can follow the ever changing needs of persons with suicidality. The aim of the literature review is to highlight experiences of nursing from the perspectives of persons with suicidality. The review is conducted as a literature review and 10 scientific articles form the basis of the literature review's results. The results of the scientific articles were analyzed and three themes emerged, experiences of the interpersonal meeting, experiences of the surrounding enviroment and experiences of being. The results show that therapeutic interpersonal engagement is one of the most important nursing interventions and contributes to person-centered care and hope. The surrounding environment of persons with suicidality affected the experience of nursing. For persons with suicidality to be able to cope with life after hospital discharge, preparation and follow-up is needed to prevent repeated suicide attempts. Further research and education is needed on how persons with suicidality experience nursing.


Many scholars consider inadequate capitalization to be the most important condition to pierce a corporate veil. However, there are many problems in judicial practice due to the lack of relevant institutions. When a court pierces the corporate veil, it places creditors' expectations ahead of insiders' interests in limited liability. So it should only happen in extreme circumstances. Although grossly inadequate capitalization is a factor in determining whether to pierce the veil, it is not dispositive. There should be either some affirmative fraud or wrongdoing by the shareholder, or a gross failure to follow the formalities of corporate existence, combined with undercapitalization, before the veil is pierced.


Large scale Demand Response (DR) has different impacts on different market actors. The impacts depend significantly on the market actor and the operational environment. The impacts of DR on electricity retailers (ER) in the North-European electricity market are discussed in this paper. DR is a double-edged sword for an ER. On one hand, DR offers a potential tool to improve the operation in the electricity market, but on the other hand, DR poses also risks to the ER. The impacts of DR on ERs depend on many things like the nature of the controllable demand, the characteristics and the rules of the market place in which DR is being operated and the structure and the nature of the electricity contracts made with the customers. These things are discussed in depth in this paper. A case study is presented related to DR based on day-ahead area prices in Finland. The case study shows that on average, the imbalance costs induced by DR to the retailer can even be positive (positive cash flow), but the risk of significant additional costs remain and might even be increasing.


Atoms and Molecules Structure of Solids Phase Transformations and Phase Equilibria Defects and Imperfections in Solids Rate Processes and Crystallization Surfaces and Interfacial Phenomena Mechanical Properties Metals Ceramics and Related Materials Polymers Electronic Properties Magnetic Properties Thermal Properties Corrosion Appendixes Tables.


Development and transformation process of alternate bars and variations in flow depth and sediment transport rate due to periodic change of water discharge are investigated on the basis of flume tests using the uniform and the graded sediment. Experimental results show that an effect of the change rate of discharge on the development and transformation is large in case of the short wave period, whereas it is relatively small in case of the long wave period. The wave height of an individual alternate bar in the graded sediment bed is lower than that in the uniform one during the flood period. This reason is that the erosion of bed in its pool is restrained by sediment coarsening caused by grain sorting. Response-lags of the wavelength and height, flow depth and sediment transport rate to discharge change are small when the wave period is long, whereas they are large when the wave period is short. Response-lag of alternate bars to discharge change in the graded sediment bed is smaller than that in the uniform one.


This study deals with the length-weight relationship and relative condition factor (Kn) of 2480 specimens of Rhinomugil corsula (Hamilton, 1822), ranging from 3.5 cm to 29.5 cm total length and 0.40 g to 235.34 g weight, sampled monthly for two years period from March 2016 to February 2018 from the Sitakunda Coast of the Bay of Bengal, Bangladesh. Arithmetic form of equations for length (TL) and weight (W) of fish showed curvilinear relationships in male: W=0.0081TL3.016, female: W= 0.0083TL3.058 and combined sex: W=0.0076TL3.052, while logarithmic scale showed linear relationships in male: LogW=-2.122+3.016LogTL, female: LogW=-2.09+3.058 TL and combined sex: LogW=-2.121+3.052TL. In all the cases the coefficient of correlations between length and weight were positive and highly significant (P<0.01). The regression coefficient 'b' values were found to be 3.01±0.11, 3.06±0.12 and 3.05±0.12 for male, female and combined sexes, respectively for two years period together. When 't' test was done, the growth was found to be isometric in case of male and combined sex and positive allometric in case of female. The relative condition factor (Kn) varied from 1.0003-1.009, 1.001-1.008 and 1.001-1.008, respectively, for male, female and combined sex in 2016-17, whereas 1.001-1.007, 1.003-1.006 and 0.992-1.008 respectively in 2017-18. The Kn values were always around '1' or a little bit more than '1' for length groups as well as monthly, indicating the excellent growth and robustness of fish due to favorable environmental condition prevailing in the habitat of the fish, in the Sitakunda coast of the Bay of Bengal.
Bangladesh J. Zool. 49(1): 91-103, 2021


Eleven selections of Townsville lucerne (Stylosanthes humilis H.B.K.) were grown with Rhodes grass (Chloris gayana Kunth.) in field plots near Townsville, North Queensland, and seed was collected at monthly intervals. At the first sampling in July hard seed contents were high (74-99 per cent), but declined steadily to values of 31-49 per cent in November. Dormancy, as assessed from the germination of scarified seed, was also high in July but declined rapidly so that by September the selections showed from 89 per cent to 99 per cent germination. The significance of hardseededness and dormancy in seed preservation and the importance of hardseededness in commercial sowings is discussed.


Groundwater which constitutes high percent of the global fresh water is the most important source of drinking water, which when polluted, have acute effects on its users. Consequently, the quality and pollution of groundwater is a health concern in the world. The target of this research is to evaluate the quality of groundwater around the Niger Delta Basin Development Authority in order to identify and analyze the distribution of the critical contaminants that affect the overall quality of groundwater water around the study area. About hundred (100) boreholes spread to cover the study area were sampled. The water samples were analyzed using standard procedures for assessing drinking water qualities in order to understand the existing condition of groundwater within the study area. Statistical analysis of the groundwater quality data was done using average weighted index method to compute the water quality index, factor analysis using principal component method to identify the groundwater contaminants affecting the overall groundwater quality and geospatial analysis using kriging interpolation method to evaluate the spatial distribution of the selected groundwater contaminants. From the principal component analysis, result revealed that; nitrate, total dissolved solids, concentration of iron, total suspended solids and turbidity were the most important contaminants affecting the quality of the groundwater. Result of geospatial analysis using kriging interpolation revealed that; the water quality parameters showed relatively strong degree of spatial dependency which made it possible to generate the spatial distribution map for the selected water quality parameters. Keywords: Geospatial analysis, Kriging interpolation, water quality index, Principal component analysis. DOI : 10.7176/JNSR/9-24-05 Publication date: December 31 st 2019


A study sheds new light on the extra-articular manifestations of spondyloarthritis—with a focus on the heart as a high-risk target.


Designer nanoparticles with complex morphologies are of growing interest for a wide range of applications, but making them rationally and scalably remains challenging. Here, we demonstrate a retros...


Dynamic resource allocation combined with adaptive antenna arrays at both the transmitter and receiver can achieve further QoS improvement in conventional OFDM systems. In this paper, we propose two different dynamic resource allocation algorithms with adaptive beamforming for MIMO/OFDM systems and investigate their performance over multipath fading channels under perfect and imperfect CSI. These proposed approaches involve the use of adaptive modulation and adaptive frequency-domain power allocation. By employing this proposed methodology, significant performance improvement can be achieved as compared to the conventional adaptive antenna arrays based on OFDM systems. It is shown, however, that the adaptive modulation based approach is too sensitive to channel estimation errors and that its performance is worse than the adaptive frequency-domain power allocation approach under imperfect CSI.


A novel compact ultra-wideband circular patch reflector reconfigurable frequency multiband antenna has been designed. The proposed structure consists of an aluminum plate (reflector), defected ground slot and circular patch. The circular antenna radius with small slot $(11 \times \mathrm{w}1)$ is optimized to obtained ultra-wideband frequency range (2.72-11GHz). After, Three PIN diode has been used in ground switchable rectangular slot with optimized place to obtain altered frequency bands from 2.63 to 10.14 GHz. with switchable slots. Thereafter, the reflector has been situated at rear of the ground with distance 21mm which generates different operating bands from 2.45 to 10.16 GHz with reflector and also obtained directional radiation pattern with enhanced directivity. The Proposed circular patch-reflector antenna has been designed with thickness of 1.9mm, on substrate Rogers RT 5880 and dielectric constant 2.2. The designed antenna has size of substrate $66 \times 66$ mm2. The simulation and analysis of proposed antenna has been done using CST (Computer simulation technology).


In this paper we describe the current state of a new Japanese lexical resource: the Hinoki treebank. The treebank is built from dictionary definition sentences, and uses an HPSG based Japanese grammar to encode both syntactic and semantic information. It is combined with an ontology based on the definition sentences to give a detailed sense level description of the most familiar 28,000 words of Japanese.


The effects of transit investments on land and housing values are a longstanding topic of interest in part because the nature and timing of those effects are important for designing anti-displacement and land value capture strategies. For these reasons, we explore whether multifamily unit rents have increased in planned station areas before the Purple Line light rail project in Maryland is operational. We employ a difference-in-difference (DID) approach to explore this question and validate the DID results with a first difference approach. We find that rents for units located within one-half mile of anticipated stations did increase well before transit service is expected to begin, but only for units with two or more bedrooms. We suggest these results imply that anti-displacement and land value capture strategies are warranted and potentially viable, but to be effective they need to be adopted well before transit service begins. Further, our results suggest that in the case of the Purple Line in Maryland, such policies should focus on units located within one-half mile of proposed stations and concentrate on preserving affordable units with two or more bedrooms.


Onboard navigational aid systems are a central topic in the road-transportation domain. The currently available systems are designed so that they usually deliver the « objectively » « optimal » routes. Drivers, however, often prefer other routes due to individual cognitive or motivational reasons. Our research program aims at identifying the cognitive processes involved in route planning, and providing ergonomic specifications for onboard systems dedicated to support drivers' route planning. We conducted two experiments in which participants were asked to plan an itinerary through a city, in which they were expected to complete tasks with spatial or / and temporal constraints. We examined if participants' cognitive activities were affected by specific environment knowledge, by tasks being constrained temporally and by time available for planning. On the basis of these results and of an ergonomic analysis of aid systems, we formulate some directions for the development of a system that might support drivers in their planning activities.


We have observed the proton spectra from equal-velocity beams of H+, H2+, and H3+ incident on aligned silicon crystals. Data for both axial and planar channeling show that the dechanneling is successively greater for the H2+ and H3+ ions than for protons. Since the depth at which dechanneling occured can be deduced from the energy spectrum of the backscattered protons, the comparison of the proton spectrum from molecular-ion bombardment with that produced by incident protons allows us to study the history of the motion in the crystal of the interacting protons from a given molecular ion.


In tumor dormancy, a sub-population of tumor cells becomes quiescent but can re-enter the cell cycle upon certain environmental cues. The re-awakening of dormant populations has been associated with tumor cell proliferation and poor patient outcomes. Tumor dormancy can be modelled in vitro by exposing cancer cells on fibronectin-coated plates to bFGF-2, a mammary differentiation factor abundant in the bone marrow stroma, which causes partial re-differentiation, cell spreading and re-expression of integrin-α5β1. We have uncovered a novel potential role for the adhesion protein Junctional Adhesion Molecule-A (JAM-A) in tumor dormancy. JAM-A overexpression has previously been linked to increased risk of metastasis in breast cancer patients, and its expression regulates the angiogenic functions of bFGF-2. Furthermore, since loss of JAM-A downregulates the α5β1 downstream effector FAK, we hypothesized that JAM-A is required for maintenance of tumor dormancy. To investigate this, JAM-A was transiently silenced in MCF-7 breast cancer cells grown on fibronectin-coated plates and exposed to FGF-2. JAM-silenced cells exhibited expressional downregulations in integrin-α5β1 and FAK proteins, and failed to exhibit the cortical actin redistribution and morphological spreading which characterize dormant cells. in parallel, pharmacologically-induced loss of JAM-A (using an anti-tumor antibiotic) prevented tumor dormancy and was cytotoxic to dormant cells. We next investigated a potential relationship between JAM-A expression and pro-inflammatory cytokines linked with the re-awakening of dormant cells in post-menopausal women. Exposure of MCF-7 cells to IL-1β, TNF-α, IL-6 and IL-8 increased the protein expression of matrix metalloproteinase ADAM17, which in turn caused JAM-A cleavage and loss from the cell membrane. Analysis of bone metastasis sections from post-menopausal breast cancer patients revealed significant heterogeneity in JAM-A expression, with some regions strongly positive for JAM-A while other regions were negative. Nonetheless, 20/24 metastatic sections expressed either moderate or high JAM-A levels, suggesting that even if cells transiently lose JAM-A to reawaken from tumor dormancy, they may later acquire high JAM-A expression during disease progression. The fact that JAM-high dormant cells had high Aldefluor activity, a feature of stemness, might also support an important role for JAM-A in tumor evolution or progression. To conclude, our data support a model whereby JAM-A is important for the maintenance of dormancy in breast cancer cells in a simulated bone marrow microenvironment, and represents a novel therapeutic target worthy of investigation in breast cancer. This work was financially supported by Science Foundation Ireland (grant 13/IA/1994 to AMH). Citation Format: Sri HariKrishna Vellanki, Rodrigo G. Cruz, Katherine M. Sheehan, Elaine W. Kay, Ann M. Hopkins. Tumor dormancy in breast cancer cells: Identification of junctional adhesion molecule-A as a novel regulator [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 54.


This paper is based on several attempts to provide a definition of an Artificial Companion that can be found in the referenced literature. Although accepted by the research community, such descriptions set very high expectations of such agents, but they do not address the technical feasibility and the system limitations, that is why they need an elaborated and precise explanation. In this paper, we focus on computer agents that simulate human language behaviour, and are aimed to serve, to assist and to accompany their owner over a long period of time, that we call Artificial Conversational Companions. This is the first approach to analyse the effort required to meet the expectations of Artificial Conversational Companion and discuss the identified design issues.


This article review work relevant to the two fastest growing nanomaterials in electrochemical sensing of metal ions: organically modified ordered mesoporous silicas (OMSs) and carbon nanotubes (CNTs). Nanostructured self-assembled monolayers on mesoporous silicas (SAMMS) materials are highly effective as electrode modifiers; they can be either mixed with conductive materials or spin-cast as a thin-film on electrode surface. The interfacial chemistry of SAMMS can be fine-tuned to selectively preconcentrate the specific metal ions of interest. The functional groups on SAMMS materials enable the preconcentration to be done without mercury, supporting electrolytes, applied potential, and solution degassing, all of which are often required in conventional adsorptive stripping voltammetric sensors. Since it was first introduced in 1991, CNTs have been widely investigated for electrochemical sensors of many important biomolecules because of their electrocatalytic and antifouling properties, biocompatibility, high surface, and mechanical strength. For trace metal analysis, CNT thin-film created by drop-coating of CNT-solvent suspensions on electrode surfaces has been explored in order to develop mercury-free sensors by exploiting the bulk properties of the CNTs. Array of low-site-density aligned carbon nanotubes has been grown on metal substrates by a non-lithographic method. Each CNT serves as a nanoelectrode which normally has greater mass transfer ratemore » and higher mass sensitivity than conventional macroelectrodes. The array of millions of CNT nanoelectrodes provides magnified voltammetric signals for trace metal ions without the need for a signal amplifier.« less


A hypothesis of the generalized sampling system is presented in this paper. The
formula of calculating MTF_1 of the CCD imaging device is strictly derived, while the
problems in some references are discussed.


The goals of this research want to know about steps of development, process of recruitment athlete's and coaches, organization, management of funding, exercise program, and facility and infrastructure as the primary factor of implementation coaching achievement at PPLP CentralJava Province. The research approach is used a qualitative descriptive approach, and that is research forgive illustration or description about some facts without making a manipulation and as the real fact. The result obtained is 1) each of sports has done the development in a proper steps, 2) process recruitment of athlete's and coaches has passed with the right ways but, there are some athlete's not follow the right ways for being an athlete's of PPLP, 3) nine (9) sport branch has made exercise program periodically and has made by their coach in each sport, 4)Organizational management PPLP Central Java have been with the excellent arranged and structural,5) on support facilities and infrastructure is still not complete and even yet available for some sports so that can distrubbing process of training in PPLP Central Java. It can be concluded that coaching is done in a PPLP Central Java has been running well, but some factors become an obstacle in the process of coaching for athletes.


Terahertz (THz) radar has developed a lot in recent years. Its ability for near field security inspection becomes a popular research topic. However, the phase errors caused by THz radar's motion are difficult to compensate due to the submillimeter wavelength, which means a tiny motion error will bring a huge phase deviation. In this paper, we report a crossed array radar imaging method, which employs fixed TX- and RX-elements collecting real-time data to avoid the phase errors caused by radar's motion. The imaging reconstruction are deduced in matched-filter and spatial frequency domain approach. Furthermore, the numerical simulation results are conducted to demonstrate the performance of this imaging method.


For over 30 years, contention has surrounded the issue of preschool children's readiness for formal schooling. A Piagetian view is that the presence and use of particular operatory structures indicative of the concrete operational stage of cognitive development are necessary for a child to achieve successful learning outcomes in the new formal education environment of primary school. In any case, the nonstandardised skills-based checklists utilised by many preschool teachers to infer children's levels of readiness for year one seem ineffectual as the debate regarding children's school readiness persists. This paper reports on the findings from a research project in which forty-two preschool children were administered a Piagetian conservation of number task as outlined in the work of Piaget and Szeminska "The child's conception of number" (1941/1952) using the Genevan methode clinique.
Participants were also routinely assessed by their teachers using the preschool's Key Indicators of Readiness for Year One (KIRYO) Checklist and, in addition, then judged qualitatively on their preschool and early year one performance by the respective teachers. Children's performances on each of the above-mentioned indicators were scored quantitatively using detailed performance criteria
derived explicitly from each item's source. Rasch analysis using the Partial Credit Model indicated that success on the conservation task was more closely aligned with children's success in year one than was mastery of the KIRYO Checklist indicators. The implications for professional discussion and decisionmaking, as well as insights for teachers of early childhood sectors are canvassed.


Under pathological conditions, promoting oxidative stress kinase to be activated in the body, mitochondrial respiratory chain abnormalities, and decreased oxygen flee radical scavenging capacity lead to increased oxygen free radicals and pro-oxidant factors. The accumulation of the above harmful substances lead to the corresponding changes of arterial wall and blood components, such as endothelium-dependent relaxation dysftmction, inflammatory cytokine activation, endothelial structural damage, vascular smooth muscle cell proliferation, and foam cell formation, thus play key roles in the processes of the occurrence and development of atherosclerosis. The role of antioxidant therapy in the prevention of cardio-cerebrovascular events remains controversial and needs to be further studied.

Key words:
Atherosclerosis;  Oxidative stress;  Endothelium, Vascular;  M itochondria;  Reactive OxygenSpecies;  Antioxidant s


Besides fast growth of Penicillium strains as compared to Trichoderma reesei,Penicilliumstrains can secret intact cellulase system,especially producing highlyβ-glucosidase,which can compensate the low activity of extracellularβ-glucosidase of T.reesei.Therefore,the cellulases fromPenicilliumhave attracted the most attention in recent years.To overcome the bottleneck of vast demand and high cost of the cellulases in industrially producing fuel ethanol from lignocelluloses,it is very important to deeply study the regulation of cellulase gene expression in Penicillium and recombinant expression of Penicillium cellulase genes.This paper reviews the aspects of cellulase gene resources fromPenicillium,regulatory network of cellulase synthesis in Penicilliumand high recombinant expression of Penicilliumcellulase genes.


Research was performed during the first year (1985) of the two-year project investigating potential responsiveness of bowhead and gray whales to underwater sounds associated with offshore oil-drilling sites in the Alaskan Beaufort Sea. The underwater acoustic environment and sound propagation characteristics of five offshore sites were determined. Estimates of industrial noise levels versus distance from those sites are provided. LGL Ltd. (bowhead) and BBN (gray whale) jointly present zones of responsiveness of these whales to typical underwater sounds (drillship, dredge, tugs, drilling at gravel island). An annotated bibliography regarding the potential effects of offshore industrial noise on bowhead whales in the Beaufort Sea is included.


The BESIII Experiment at the Beijing Electron Positron Collider (BEPC2) collected large data samples for electron-positron collisions with center-of-mass above 4 GeV during 2013 and 2014. In this mass region, there are several states that are yet to be understood. In this article we will discuss BESIII analyses of the exotic Zc states. We present the studies of their decays to hidden charm and open charm final states for both the charged and neutral Zc states.


Abstract Rapid change, high workloads and increased complexity in working environments has created the need for personal work resilience. This paper explores the concept of employee resilience within the geoscientist environment and especially the mineral industry. It uses as its framework for defining resilience the Resilience at Work (RAW) Scale, a seven-factor model that outlines areas of resilience that can be developed at an individual level. Specific practical strategies applicable to the challenges of employment in the cyclical resource sector are presented.


e have a growing education al priority to address social and cultural diversity and various forms of oppression (e.g., racism, sexism, heterosexism, classism). Increas ingly, classes include material about a wider range of people's lives and direct discussions about the politics of differ ence and inequality. In most cases, facul ty members are intentionally trying to create a more inclusive curriculum; at other times, students are raising these issues, whether or not this was the teacher's agenda. Even though they often have good intentions and the desire to deal with mul ticultural issues in their classes, many teachers admit uncertainty about how to actually do it. There are fears and anxiety about how to approach and manage the discussion. These emotional issues may challenge deeply held beliefs and atti tudes. Although there are growing num bers of resources to address the content? activities, syllabi, books, and videos, few resources discuss the process (see Fisher


The paper states the connotation of the higher education internationalization,sums up the essential of five respects of higher education internationalization,differentiates and analyzes the relation of higher education that moves from divergence towards partly convergence under the globalization background.On this basis,it puts forward the problem and relation needing handling well in the internationalized trend of higher education in our country.


A new application of Time Reversal Mirrors (TRM) is introduced in this work. It is similar to radar surveillance, detecting and tracking moving object(s) in a remote area using seismic waves; this includes the exact location of the moving object and its speed. Recordings of high signal-to-noise ratio reference Green's functions are required, where they are used as calibration records or moving sensors. The proposed method is tested with a field experiment.


Commonly, there is a sense that once the baby has been safely birthed, the important work is finished. Conversely, the hour immediately after birth is crucial to the psychobiological health for all mothers and babies, and the effects are evident well into the postnatal period and beyond. Understanding what the primitive mammalian mother-infant dyad are expecting to survive and optimise their post-birth health, we can reflect on what and how our practices affect this important emerging relationship. This final article in the Normal Birth series will explode the misunderstanding that physiological birth ceases with the birth, providing you with the knowledge to support this critical period.


An "r-consecutive-k-out-of-n: F system" consists of n linearly or cyclically ordered components. The system fails if and only if at least r nonoverlapping sequences of k consecutive components fail. In this paper, we give recursive formulas to compute the reliability of circular "r-consecutive-k-out-of-n: F system" in general case. More precisely, our goal in the present paper is to give formulas to evaluate the reliability of the circular "r-consecutive-k-out-of-n: F system" via those of a linear one.


Because of its far-reaching effects, diabetes remains a major health problem on a worldwide scale. It's a metabolic illness that causes hyperglycemia and a host of other health issues, including cardiovascular disease, renal failure, and neuropathy. Many scientists have spent time and energy over the years trying to develop a reliable diabetes prediction model. Researchers are forced to adopt big data analytics and machine learning (ML)-based methodologies since there are still major open research concerns in this area owing to a lack of acceptable data sets and prediction techniques. This study seeks solutions by way of an examination of healthcare predictive analytics. The major purpose of this research was to explore the potential applications of big data analytics and machine learning-based approaches in the field of diabetes. In this study, we used the neutrosophic AHP as a feature selection method. The neutrosophic AHP is used to compute the importance of features, then apply the machine learning methods to these features. This study applied logistic regression, support vector machine (SVM), and random forest (RF) to predict the disease of diabetes.


Thermoelectric power measurements are reported for seven samples with different x in the Gd1.85-xSmxCe0.15CuO4 system at temperatures ranging from 80K to 300K. For Sm-rich superconducting samples, thermoelectric power S has a small negative value and is almost temperature independent. As the content of Sm decreases, the absolute value of S increases and a broad valley appears in the S(T) curve. The results which can be interpreted in terms of a two-channel model support the existence of mid-gap states with Fermi level close to the minimum of the density of states as well as the coexistence of electron and hole carriers. It is suggested that a linear temperature dependence of S with a small negative slope is close to the intrinsic behavior in the a-b plane of normal states for superconducting samples.


This paper describes how the combination of speaker verification algorithms with a priori decision thresholds can improve the overall robustness of a real application. The evaluation is performed in the context of a field application where each client is verified from a seven-digit personal identification number (PIN code). This paper demonstrates that it is possible to increase the global performance of the system by combining the results of several algorithms.


The health benefits of exercise,and its essence is to improve the training of health-related physical fitness,to improve the overall health and quality of life.Taijiquan fitness for the elderly into the impact of cardiorespiratory endurance,muscle strength,muscle endurance,flexibility and body composition.In this paper,the study of Taijiquan for the synthesis of shadow boxing to improve the health of the effectiveness of fitness,thereby guiding the elderly to provide the scientific basis for fitness.


Abstract Detailed analysis of trilobite assemblages at the Cambrian–Tremadoc transition reveals the presence of four, possibly five, biogeographic provinces: Baltic, North China, Southeast China, North American, and possibly Siberian. One or more discrete biofacies characterize the transition in each province. When plotted palaeogeographically these appear to be largely temperature controlled. Interdigitation of provincialized trilobite biofacies is recognized by the representation of dominant types of trilobite, olenaceans, ceratopygaceans, remopleuridaceans, dikelocephalaceans and leio-stegiaceans in particular, on key boundary sections. These sections, at Nochixtlán, Mexico; Batyrbay, southern Kazakhstan; Broken Skull River, District of Mackenzie, Canada; and Jiangshan–Chang-shan, western Zhejiang, China, permit the correlation of biogeographic provinces globally. As a result of the application of trilobite biostratigraphy relatively few problems prevent the maintenance of a Cambrian–Ordovician Boundary stratotype section in its traditional Baltic biogeographic setting.


Extended main-sequence turnoffs (eMSTOs) apparent in most young and intermediate-age clusters (younger than ∼2 Gyr) are known features caused by fast rotating early-type (earlier than F-type) stars. Late-type stars are not fast rotators because their initial angular momenta have been quickly dispersed due to magnetic braking. However, the mass limit below which stars have been magnetically braked has not been well constrained by observation. In this paper, we present an analysis of the eMSTO of NGC 6819, an open cluster of an intermediate-age (∼2.5 Gyr), believed to be comparable to the lifetime of stars near the mass limit for magnetic braking. By comparing the observation with synthetic color–magnitude diagrams, we find that NGC 6819 does not harbor an obvious eMSTO. The morphology of its turnoff region can be readily explained by a simple stellar population considering the observational uncertainties as well as the differential reddening. In addition, the MSTO stars in NGC 6819 have very small values of average rotational velocity and dispersion, indicating that they have undergone significant magnetic braking. Combining with results in the literature for clusters of younger ages, our current work suggests that the critical age for the disappearance of eMSTO in star clusters must be shorter but very close to the age of NGC 6819, and this in turn implies a critical stellar mass for magnetic braking at solar metallicity above but close to 1.54 M ⊙ based on the PARSEC model. We emphasize that the phenomenon of eMSTO could provide an unique way to constrain the onset mass of magnetic braking.


ALTHOUGH THE BUSH ADministration has refused to join international efforts to reduce greenhouse gas emissions, more than half the states have adopted voluntary or mandatory policies that address climate change. A California law requires its Air Resources Board to develop rules by January 2005 to reduce C0 2 emissions from motor vehicles. Texas has decided that 3 to 4% of its energy will come from renewable sources, especially wind. Massachusetts set limits on C0 2 emissions from six major coal- and oil-burning utilities that provide about 40% of its electricity. New Jersey set a goal of reducing overall C0 2 emissions 3.5% below 1990 levels by 2005. According to a new study by the Pew Center on Global Climate Change, states led by Democrats, Republicans, and Independents alike have taken such actions, usually to address a crisis within the state. "The report shows that addressing climate change is not only possible but can be done in ...


The invention relates to a low-carbon olefin catalyst prepared from low-carbon alkane through dehydrogenation and a preparation method of the catalyst, and mainly solves the problem of low mechanical strength of the catalyst after a carrier is formed in the prior art. The technical scheme comprises the following that: a pseudo-boehmite raw powder or aluminum oxide raw powder is doped with pseudo-boehmite or aluminum oxide raw powder with smaller average particle size, a forming assistant such as Sesbania and the like is added, and a cylindrical carrier is obtained by kneading and squeezing; and a platinum-tin catalyst is obtained by loading the obtained carrier with a platinum component and a tin component by an impregnation method, namely, impregnating aqueous solutions of soluble salts of the platinum component and the tin component, and drying and roasting and processing with water vapour. According to the technical scheme, the problem of the low mechanical strength of the catalyst after the carrier is formed is solved well. The catalyst can be used for industrial production of preparing low-carbon olefin catalyst from low-carbon alkane through dehydrogenation.


The presence of an observer was hypothesized to heighten self-focused attention for students rehearsing interviewing skills in a classroom setting. Pairs of undergraduates were randomly assigned to interview each other in the presence (8 pairs) or absence of an observer (7 pairs). Results supporting the hypothesis were marginally significant. A supplementary finding indicated that differences between the sex of an interviewer and observer did mediate self-focused attention. An explanation for this finding is discussed using objective self-awareness theory.


Introduction: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvascular damage and fibrosis of the skin and internal organs. The major complications are lung fibrosis, pulmonary artery hypertension, scleroderma renal crisis, and cardiac involvement. Objective: The aim of this study was to assess renal and cardiac involvement in asymptomatic SSc patients using renal Doppler ultrasound (RDU) and cardiac magnetic resonance (CMR). Materials and Methods: We enrolled 26 consecutive SSc patients (21 female) according to 2013 ACR/EULAR criteria. Biochemical analysis, clinical evaluation, RDU with intrarenal hemodynamic parameters (renal resistive index [RRI], pulsatility index [PI], systolic/diastolic [S/D] ratio), and CMR with late gadolinium enhancement (LGE) were investigated at the time of enrollment. Results: The median PI value was significantly (p = 0.007) higher in SSc patients with LGE than in SSc patients without LGE (1.37 [1.28–1.58] vs. 1.12 [1.06–1.26]). The median RRI value was significantly (p = 0.002) higher in SSc patients with LGE than in SSc patients without LGE (0.68 [0.65–0.73] vs. 0.64 [0.63–0.65]). The median S/D ratio was significantly (p = 0.02) higher in SSc patients with LGE than in SSc patients without LGE (3.12 [2.83–3.76] vs. 2.78 [2.64–2.84]). Conclusions: Our study, although performed on a small SSc population, showed RRI and LGE as markers of vascular and fibrotic damage. Early detection of cardiorenal involvement in SSc patients without symptoms is important to avoid further complications.


Resid is the nondistillable portion of crude oil, generally thought to consist largely of unsaturated molecules of considerable size and ring number. Such molecules must be upgraded to more saturated compounds if they are to be used as fuel sources. Current processing of resid is performed though coking, thermal and catalytic cracking, deasphalting and hydroprocessing. Thermal treatments, however, produce large quantities of low-value coke and hydroprocessing is expensive. Asphaltenes comprise the most process resistant portion of the resid. They contain high concentrations of heteroatoms and a high degree of unsaturation. Because these undesirable characteristics are concentrated in asphaltenes, finding an improved method of upgrading asphaltenes is a prerequisite to improving the upgrading of whole resid to viable fuel. Asphaltenes have, at present, only an operational definition. They are insoluble in straight chain saturated hydrocarbons. Very little is known about the structure of compounds in asphaltenes. They are a highly diverse group of compounds that are resistant to analysis by conventional methods. Conclusions about the structures of asphaltenes tends to be speculative. In this study desorption electron impact (HREIMS), chemical ionization high resolution mass spectrometry (HRCIMS), and laser desorption mass spectrometry (LD) have been applied to deasphalted oils (DAO) and asphaltenesmore » derived from heavy Maya resid. LD data should yield information on the high molecular weight aromatic compounds, while HRMS can provide molecular characterization.« less


The conjugated linoleic acid (CLA) is a bioactive lipid found in natural form, mainly in food derived from ruminants. It has been demonstrated that supplemen...


The fibrous cellulose product such as handkerchief or serviette, produced by associating at least two plies of cellulose wadding, cut to desired size and bonded together along a peripheral zone characterized in that said pleats are linked along said area by gluing, so as to present a minimum resistance to delamination of 1 g / cm, said peripheral area representing less than 50% of the total surface of the product.


This article offers ways to understand how a fifth-grade resistant writer positioned himself socially and academically within classroom writing practices and how these positions influenced literacy learning. Classroom writing practices enabled the student to explore the possibilities of who he was as he determined what types of learning were socially available to him. The student's voice is heard to describe how he was using writing in creative ways to position himself. He engaged in positional writing practices to create spaces for himself to influence and to examine his and others' positions. Effective instructional approaches and implications for teaching are discussed.


This article addresses the computational challenges of learning strong substitutes demand when given access to a demand (or valuation) oracle. Strong substitutes demand generalises the well-studied gross substitutes demand to a multi-unit setting. Recent work by Baldwin and Klemperer shows that any such demand can be expressed in a natural way as a finite list of weighted bid vectors. A simplified version of this bidding language has been used by the Bank of England. Assuming access to a demand oracle, we provide an algorithm that computes the unique list of weighted bid vectors corresponding to a bidder's demand preferences. In the special case where their demand can be expressed using positive bids only, we have an efficient algorithm that learns this list in linear time. We also show super-polynomial lower bounds on the query complexity of computing the list of bids in the general case where bids may be positive and negative. Our algorithms constitute the first systematic approach for bidders to construct a bid list corresponding to non-trivial demand, allowing them to participate in "product-mix" auctions.


To date, the majority of engineers in UK industry have acquired their qualifications and skills from a 'traditional' engineering education, and tend to specialise in a particular 'branch' or discipline of engineering or science.


This work focuses on improving the Hopfield network for solving optimization problems. Although much work has been done in this area, the performance of the Hopfield network is still not satisfactory in terms of valid convergence and quality of solutions. We address this issue by combing a new activation function (EBA) and a new relaxation procedure (CR) in order to improve the performance of the Hopfield network. Each of EBA and CR has been individually demonstrated capable of substantially improving the performance. The combined approach has been evaluated through 20,000 simulations based on 200 randomly generated city distributions of the 10-city traveling salesman problem. The result shows that combining the two methods is able to further improve the performance. Compared to CR without combining with EBA, the combined approach increases the percentage of valid tours by 21.0% and decreases the error rate by 46.4%. As compared to the original Hopfield method, the combined approach increases the percentage of valid tours by 245.7% and decreases the error rate by 64.1%.


The study introduced a series of reformation and practices on teaching content,teaching methods and so on of An Introduction to Genetic Engineering in Guangdong Ocean University. Then some reformed effects were analyzed.


ABSTRACT In Democracy for Realists, Christopher Achen and Larry Bartels argue provocatively that the public falls far short of ideals of democratic citizenship, and they turn to political psychology to explain the empirics of mass political behavior. But their model of group identity fails to shed much light on the origins of political behavior and gives members of the public less credit than they deserve, for three reasons. First, group politics is not a hollow exercise; it depends on the identification of a collective grievance that has a potential political solution. Second, concerns about group economics, status, and respect are more likely than individual economic considerations to animate political behavior, yet the former concerns are no less rational than the latter. Third, individuals vary in how strongly they identify with politically relevant groups, masking considerable variation in the degree to which group affiliations shape political behavior. Therefore, group identification is not a monolithic, irrational force that affects people regardless of their perceptions of political reality.


The genetically determined macrocytic anaemia of adult WvWv mice was cured by treatment with allogeneic (CBA) haemopoietic cells following 7 days immunosuppression with antilymphocytic serum (ALS). The immunological status of these mice was studied by following the fate of two skin grafts—one derived from the same allogeneic donor as the haemopoietic cells (CBA), and the other (A strain) completely unrelated to both the host and the haemopoietic cells. The A strain grafts were rejected while the CBA strain grafts were never rejected. It was concluded that the mice had become specifically tolerant to the CBA genotype. Following studies with chromosome markers, it was found that this tolerance was associated with a high degree of cellular chimaerism.


Online social networks have changed the way people communicate, create content and share it via online social actions. In order for users to engage in a social network application, they need mechanisms that will help them to find other users that they can trust in some context and also qualitative and useful content. Reputation systems offer such mechanisms and are thus essential in Social Networks (SNs). Due to their open and social nature and to their different objectives, reputation systems for SN-based applications comprise of various different mechanisms which fulfill the different objectives in the specific application context. There is thus the need for a systematic study of the specific aspects of these systems, which can provide insights for the design of reputation systems in specific application contexts. In our paper we present a taxonomy of reputation systems for various SN applications based on their specific aspects. We then use this taxonomy to design a reputation system for microblogging systems and present our implementation for a reputation system for Twitter which estimates a specific notion of reputation; the influence of users and of specific subjects of discussion.


All people, rich and poor, would like to be in good health, not being
ill or getting sick, movable to where they like to go, and able to work
as desired. When people were not sick or ill, and they seem to be
in good health, they should also have satisfaction with the quality
of their life at a certain level.


In the history of modern Chinese literature,Zhou Zuoren is sure not to be ignored as a real being. It's helpful for us to further comprehend such a complicated character in literary circle by dissect him deeply. Zhou, a foresight in May 4th Movement, descended to a literati and traitor to China. The key reason is that there was a self-appreciation and a lonely feeling of individualism in his mind and a corresponding uncertain soul. That is just like a ghost, coursing his w hole life.


Theater has become more popular over the years. It is generally known to people as a building designed for the performance of plays, dances, etc. This paper is aimed at espousing the pertinence of theater in national development, especially in a developing African nation-state like Nigeria. In doing this, the paper identifies and discusses the exploitable prospects and problems that go along with the deployment of theater in enhancing Nigeria's development. The paper concludes that despite the challenges, theater plays a vital role to play towards creating a reliable, effective, and responsive representative institution and in advancing the frontiers of development of the Nigerian society.


Isooctenyl alcohols were prepared from hydrolysis of diisobutylene monochlorides which were obtained by chlorination of diisobutylene. Analysis and identification of diisobuylene monochloride and isooctenyl alcohol and hydrolysis of the diisobutylene monochloride to isooctenyl alcohol in the presence of alkalis and solvents were studied. The following results were obtained.(1) Structures of the products were determined by the comparison of their IR and NMR spectra with those of authentic compounds. The diisobutylene monochloride contained 1-chloro-2-neopentyl-2-propene, cis-1-chloro-2, 4, 4-trimethyl-2-pentene, trans-1-chloro-2, 4, 4-trimethyl-2-pentene and 3-chloro-2, 4, 4-trimethyl-1-pentene, and the isooctenyl alcohol contained 2-neopentyl-2-propene-1-ol, cis-2, 4, 4-trimethyl-2-pentene-1-ol, trans-2, 4, 4-trimethyl-2-pentene-1-ol and 2, 4, 4-trimethyl-1-pentene-3-ol.(2) Reaction conditions in the presence of alkalis were studied. Among the alkalis used, sodium carbonate, sodium bicarbonate and calcium hydroxide gave favorable results, and the optimum pH value was in the range of 8∼11. When a strong alkali such as sodium hydroxide was used, favorable results were obtained by keeping pH at 8∼10.(3) DMSO was found to be one of most effective solvents in that the rate of hydrolysis was high and primary isooctenyl alcohols were obtained in high selectivity.(4) The kinetic studies showed that hydrolysis of monochloride was of the SN2 type.(5) Examination of the product composition during hydrolysis in DMSO showed that secondary monochloride changed to primary isooctenyl alcohols by isomerization. The reaction path of four isooctenyl chlorides, which were contained in the monochloride, was discussed.


There are many types of enterprise resource planning (ERP) systems, ranging from very large and very functional vendor products such as provided by SAP and Oracle, through in-house systems, and smaller vendor products. Thus there is a substantial range of enterprise computing support available for manufacturing organizations and their manufacturing planning and control. The Global Manufacturing Research Group (GMRG) has collected a systematic survey of manufacturing organizations around the world, providing a picture of manufacturing operations. We have taken GMRG data and organized it around seven levels of ERP functionality, and analyzed this data in terms of effectiveness in terms of how ERP systems are used in global manufacturing firms, their role in accomplishing manufacturing planning and control, the relationship between ERP forms and data management practices, the satisfaction firms have across ERP forms, and finally relative perceived benefits and costs across ERP forms.


Six compounds isolated from unsaponified fraction of crude petroleum ether extracts of Curcuma longa L. rhizomes and Nicandra physaloides L. herb were compared for their acaricidal activity with the crude petroleum ether extract of both plants against Tetranychus urticae Koch females. The biological potency of the crude petroleum ether extract of both plants as well as the compounds isolated were assayed against the adult females. Petroleum ether extract of C. longa and the different compounds isolated from the unsaponifiable fractions were more toxic to the adult females than N physaloides extract or its isolates. At LC 50 level, Cu I isolated from C. longa ranked the first between the different compounds isolated and the triterpenoids isolated from N. physaloides were the least effective. Newly emerged adult mite females offered discs treated with median concentration (0.153 %) of crude petroleum ether extract of C. longa or its isolates and the median concentration (0.5 %) for N. physaloides crude extract and their isolates induced serious effect on the biotic potential of female adults. A high significant reductions in egg production and percentage mortality together with serious increase in percent sterility were recorded. However, no significant effect was recorded on eggs hatchability. In studying the bioresidual effect of the crude extract of both plants under semi field conditions, both extracts proved to have a lasting effect of 7 days against the adult females.


Our consulting group has completed 12 concert rooms or opera houses with controllable partially coupled chambers, and we have three either under construction or on the drafting boards. This paper provides a very brief overview of this approach to auditorium design and gives a rough idea of how this design feature might evolve during the next 5 years, with some reference to adjustability of the cubic volume of the primary chamber, and to the location of the openings into the secondary chamber.


This paper analyzes the opportunities and subjects brought about by the internationalization of the "one belt and one road" initiative of China's vocational education, and the development of China's Vocational Education under the background of "one belt and one road", and expands the international development way of China's Vocational Education under the concept of "one belt and one road". The mode of cooperation in the internationalization of education is the active investigation of the "national" system, which invites the development of international educational innovation to promote the internationalization of Vocational Education in China, to strengthen the internationalization structure of colleges and to enhance the quality of international competence training.


The 'immediacy' of feedback on academic performance is a common characteristic shared by both Learning Analytics (LA) and Formative Assessment (FA), and such immediacy could be facilitated by supporting the mobility of learners. However, there is little literature that investigates the significance of combining these two techniques. Therefore, this paper will discuss the analytical application called Quiz My Class Understanding (QMCU) which was purposely developed to investigate the significance of the combination between LA and FA techniques in order to provide students with immediate detailed feedback. Furthermore, it reports on a case study which reflects the role QMCU students' centered mobile dashboard in increasing the students' engagement with the QMCU dashboard.


The various green mortar mixes have been used in this study using various percentages of waste glass powder (WGP), steel slag (SG) and Micro-silica fume(SF).The different properties of flow, density, ultrasonic pulse velocity (UPV), compressive and flexural strengths have been tested for such green mortar in the  first phase of experimental work. The second phase deals with the regression analysis of such properties. Whereas, the analysis of the results have also been using the integrated AHP and TOPSIS methods for selection the best performance of the green mortar due to the ecological effects of such materials. The results showed that the use of 70%OPC+8%WGP+12%SG+10% SF indicated as the best performance in term of ecological impact compared with other mortar mixes. Also, the regression analysis using the integrated AHP and TOPSIS methods gives an effective strategy for the selection of the best mortar mix.