Expressions for the moments of the radius of gyration and for the averages of the invariants of the inertia (gyration) tensor are derived for the helical wormlike chain by the use of the moments of its multivariate distribution function. The distribution function of the radius of gyration is constructed by the weighting function method on the basis of its moments. The moments of inertia tensor (its mean principal values) are evaluated approximately by replacing its three invariants by their averages. It is numerically shown that the distribution of the radius of gyration changes from a delta function to the well‐known form in the coil limit as the contour length is increased from zero to infinity, its shape being much sharper than that of the distribution of the end‐to‐end distance. The results for the moments of inertia tensor lead to the conclusion that for the typical helical wormlike chain, its asymmetric shape in the coil limit persists down to relatively small contour length, and it never becomes sp...


Between 2010 and 2013 the University of Sussex hosted the ESRC-funded project entitled 'The Living Standards of Working Households in Britain, 1904-1960' (RES-062-23-2054). The aim of the project was to transcribe and analyse large-scale government surveys administered in the first half of the twentieth century. The aim of the knowledge transfer component of the project was to facilitate the teaching of new research on British living standards in UK schools. The knowledge transfer component of the project was undertaken in partnership with The National Archives. The National Archives had experience of running a number of 'teacher scholar' programmes. A 'teacher scholar' could be defined as a teacher who becomes expert on a particular topic through academic activities, such as attending lectures, reading, and examining primary 'evidence' (such as documents, statistics, landmarks etc), and then uses this knowledge to inform the lessons they write. The lessons developed by the teacher scholars would be shared with other teachers who did not attend the programme by being made available to download online. The Sussex project team worked with Andrew Payne, Head of Education and Outreach at TNA, and Ben Walsh, teacher, author and senior GCSE history examiner, to develop a teacher-scholar programme on the subject of modern British living standards.
Dr Samantha Shave was responsible for liaison between the TNA and Sussex teams and wrote this report about the Programme at the end of the project in 2013, in order to capture the development of the programme, what happened on the programme and how it worked. This report hopes to serve as inspiration for academics in the humanities and social sciences who are planning or embarking on knowledge transfer and impact projects.


Introduction. About 60% of patients with large B-cell lymphoma (LBCL) relapse after standard of care (SOC) anti-CD19 autologous chimeric antigen receptor (CAR) T-cell therapy, CD19 downregulation representing a major mechanism of resistance. Therefore, agents able to target B-cell antigens other than CD19 could be clinically effective for these patients. Polatuzumab vedotin (PV) is an antibody-drug conjugate targeting CD79b, and approved by the FDA in combination with bendamustine and rituximab for patients with relapsed or refractory (r/r) LBCL. Patients who relapsed after CAR T-cell therapy were not included in the registration study, and reports of PV use after CAR T-cells in real world practice are very limited.
 Methods. This is a multi-center retrospective analysis of patients with LBCL who relapsed after SOC CAR T-cell therapy and subsequently received SOC PV with or without rituximab and bendamustine between 07/2019 and 04/2021. PV was given at the standard dose of 1.8 mg/kg IV every 3 weeks in all patients (except for one patient, who received 1.4 mg/Kg). Response to treatment and progression were defined according to 2014 Lugano criteria. Survival curves were calculated using Kaplan-Meier estimates, and were compared between subgroups using the log-rank test. Cox regression was used for multivariate analysis (MVA).
 Results. Fifty-four patients were included in the study: median age was 59 (range, 22-79 years), 38 (70%) were male, and 30 (56%) had an internal prognostic index score > 3. Median number of systemic therapies before CAR T-cell therapy was 2 (range, 2-6), 16 (30%) patients previously had autologous stem cell transplant (SCT), and 2 (4%) had allogeneic SCT. Sixteen (30%) patients were primary refractory to CAR T-cell therapy, and median time from CAR T-cell therapy to PV was 5 months (range, 1-40 months). CD19 status at time of relapse after CAR T-cell therapy was assessed by immunohistochemistry and/or flow cytometry in 41 patients, and positive in 34 (83%); CD79b status was assessed in 14 patients, and positive in all cases (100%). Thirty-two (59%) patients received PV-based therapy immediately after CAR T cell therapy, while 22 (41%) had intervening treatments (median 1, range 1-5). At time of PV initiation, median absolute neutrophil count was 2.9 (range 0.5-19 X10 9/L), median platelet count was 87 X10 9/L (range 15-437 X10 9/L), median serum creatinine was 0.9 mg/dL (range 0.4-22 mg/dL), and 44 (81%) patients had elevated serum lactate dehydrogenase (LDH).
 The median number of PV cycles was 2 (range, 1-16): PV was combined with rituximab in 51 (94%) patients, and administered with bendamustine in 33 (61%). A response was achieved in 24 (45%) patients, including complete remission (CR) in 8 (14%) patients and partial remission in 16 (30%)(Figure A), with a median duration of response of 11 weeks (95%CI, 5-17 weeks). No significant association between baseline characteristics and response was observed. To date, 49 (91%) patients stopped PV: 38 (70%) due to progression, 7 (13%) because of CR/patient decision, 3 (6%) to proceed to allogeneic SCT, and 1 (2%) to proceed to an immunotherapy clinical trial (despite absence of progression). No patients stopped therapy because of toxicity.
 After a median follow up of 45 weeks (95% CI, 20-70 weeks), 44 (81%) patients progressed/died, and median PFS was 9 weeks (95% CI, 4-14 weeks). To date, 34 (63%) died, and median OS was 16 weeks (95% CI, 13-19 weeks)(Figure B). Causes of death included progression in 31 patients and transplant-related complications in 3. On univariate analysis, a shorter median progression-free survival (PFS) was observed for patients with bone marrow (BM) involvement (3 vs 10 weeks, p=0.002), prior central nervous system involvement (4 vs 10 weeks, p=0.02), and elevated LDH (6 months vs not reached, p=0.004). On MVA, the association was maintained only for BM involvement (hazard ratio [HR] 4.8; 95% confidence interval [CI] 1.6-12.5, p=0.004) and elevated LDH (HR 5; 1.4-16.7, p=0.01)(Figure C).
 Discussion. PV is safe and effective, but has short duration of response in r/r LBCL after anti-CD19 CAR T-cell therapy, except for patients with normal LDH. Studies aimed at better characterizing intrinsic mechanism of resistance, including upregulation of BCL2 family proteins, to favor the development of more effective PV-based combination strategies for these patients, are warranted.
 Figure 1 Figure 1.

 Crombie: Roche: Research Funding; Merck: Research Funding; Abbvie: Research Funding; Bayer: Research Funding; Karyopharm: Consultancy; Incyte: Consultancy. Kamdar: Celgene (BMS): Consultancy; Adaptive Biotechnologies: Consultancy; Genentech: Research Funding; Kite: Consultancy; AstraZeneca: Consultancy; ADC Therapeutics: Consultancy; Genetech: Other; TG Therapeutics: Research Funding; SeaGen: Speakers Bureau; Celgene: Other; KaryoPharm: Consultancy; AbbVie: Consultancy. Hess: ADC Therapeutics: Consultancy; BMS: Speakers Bureau. Neelapu: Takeda Pharmaceuticals and related to cell therapy: Patents & Royalties; Kite, a Gilead Company, Bristol Myers Squibb, Merck, Poseida, Cellectis, Celgene, Karus Therapeutics, Unum Therapeutics (Cogent Biosciences), Allogene, Precision BioSciences, Acerta and Adicet Bio: Research Funding; Kite, a Gilead Company, Merck, Bristol Myers Squibb, Novartis, Celgene, Pfizer, Allogene Therapeutics, Cell Medica/Kuur, Incyte, Precision Biosciences, Legend Biotech, Adicet Bio, Calibr, Unum Therapeutics and Bluebird Bio: Honoraria; Kite, a Gilead Company, Merck, Bristol Myers Squibb, Novartis, Celgene, Pfizer, Allogene, Kuur, Incyte, Precision BioSciences, Legend, Adicet Bio, Calibr, and Unum Therapeutics: Other: personal fees. Lin: Novartis: Consultancy; Bluebird Bio: Consultancy, Research Funding; Juno: Consultancy; Kite, a Gilead Company: Consultancy, Research Funding; Celgene: Consultancy, Research Funding; Janssen: Consultancy, Research Funding; Gamida Cell: Consultancy; Sorrento: Consultancy; Legend: Consultancy; Takeda: Research Funding; Merck: Research Funding; Vineti: Consultancy. Strati: Astrazeneca-Acerta: Research Funding; Roche-Genentech: Consultancy.


The idea of sustainable consumption was first brought to widespread attention as a global issue. However, government is increasingly applying it, but there is a need for industry to play a vital role in making consumption pattern more sustainable. The dominant approach to managing sustainability issue has been the construction of Environmental Management System (EMS) based on ISO 14001 standard. However, it is feared that the management decision-making will tip the balance too far in favour of business interests as against sustainable consumption interests. A conceptual model for corporate consumption is suggested in terms that provide a context for implementation of EMS based on ISO 14001. In response to inherent uncertainty, a dematerialisation strategy is adopted. The implications of this model for structuring salient elements of EMS are then discussed. The audit would measure the extent to which an organisation has a management system competent to make consumption pattern more sustainable.


The national and international codes and standards and the literature consider the stress patterns either in case of a single crack or of equidistant primary cracks which developed at the same load level. Moreover, most FE models consider smeared cracks which do not allow for any insight in the real inner behavior of structural concrete. This paper considers the stochastic character of the concrete tensile strength's distribution along the reinforced concrete element and a realistic local bond stress vs. slip relationship with its hysteretic character when the sign of local slip changes due to the occurrence of a new primary crack.


INTRODUCTION
The objective was to compare the two-year ultrasonographic outcomes in a consecutive series of patients with acute Achilles tendon rupture (ATr), either treated surgically or nonoperatively.

MATERIALS AND METHODS
This is a prospective, single-center, consecutive series. All patients presenting with acute ATr were included and divided into two groups: surgical or nonoperative groups. At two years, patients were evaluated clinically and sonographically. The parameters studied were length of the tendon on the rupture side (LTCR) and on the contralateral side (LTCS), ratio LTCR/LTCS, maximum anteroposterior diameter on the rupture side (DAPMR), maximum surface area on the rupture side (SMR), maximum anteroposterior diameter on the contralateral side (DAPMS), and maximum surface area on the contralateral side (SMS). Morphological changes in tendon structure were reported.

RESULTS
Thirty patients were included. No difference in functional score was observed between both groups. In the nonoperative group, there is a significant difference between: LTCR and LTCS; DAPMR and DAPMS. In the surgical group, there is a significant difference between: LTCR and LTCS; DAPMR and DAPMS; SMR and SMS. There is a significant difference when comparing SMR/SMS between both groups. In terms of morphological changes in tendon structure, there were differences.

CONCLUSION
At two years, there was no difference in functional outcomes between the two groups. In both groups, AT were lengthened and thickened without differences between groups. There was a significant difference when comparing the ratio SMR/SMS between groups. Ultrasound examination demonstrated different morphological changes in tendon structure depending on the treatment performed.


The convergence of a neural network model based on optical resonator designs is examined for Boolean logic operations. Computer simulations are performed to investigate convergence performance and to assess possible optical implementations. The model is a simple and general mathematical formulation obtained using standard methods in which plane wave amplitudes and phases are specified at discrete times separated by the resonator period. The model is trained and tested as an associative memory neural network using an input state vector and a hologram matrix that evolves in time according to a set of coupled nonlinear difference equations. In general, these equations represent a high-order threshold logic, and the hologram matrix is a function of the outer product matrix of the evolving complex-element state vector. Model parameters are explored to provide insight on convergence mechanisms, robustness to input perturbations, and optimization of convergence times for both training and testing. The model is of interest for optical resonator designs that incorporate (1) dynamic holograms for massively parallel interconnection and storage functions and (2) nonlinear components such as phase conjugate mirrors (with thresholding and gain) for decision operations.2 These components are often incorporated into resonator loops to provide feedback and adaptation interactions. The neural


: The present research work is an attempt made of to measure water. Quality of Ganga river at hajipur, Bihar. Physico-Chemical status of the Ganga river were conducted during Nov.2017 to Oct 2019. On the basis of present study some parameters like temp., pH, TDS, Turbidity, Conductivity & Do are carried out in present research work. The result revealed well defined monthly variation. The whole river, at hajipur is getting polluted due to intense human activity.


The conditions for preparing sodium trimetaphosphate by heating monosodium orthophosphate dihydrate have been studied. It has been found that the use of thicker samples allows a lower temperature and a shorter heating period to be used. Sodium trimetaphosphate of very high purity can be prepared by heating a sample 2·4 cm. thick for 1/2 hour at 500°.


The increase in pore water pressure in earth-rock fill dams with clay core during construction and first watering can cause the start and progress in hydraulic fracture. Construction costs being high and also the damage caused by dams' fracture make the necessity of taking care and behavior survey of earth dams, more obvious than anything. According to this, in this research while modeling Gelabar earth dam, pore water pressure, pore water pressure ratio, the amount of total stress and effective stress, arching and lateral soil pressure ratio is measured and has been compared with the amount measured by precise instruments which has the construction capability of Plaxis v8.5 for numerical modeling from two –dimensioned software, has been used. Behavior models used in this analysis, Moher- Coulomb and it is xis v8 hardening. Considering the data of precise instruments installed on Dam's body and implementing return analysis, real parameters of construction materials was obtained. Evaluation of numerical modeling results and precise instruments can find out an appropriate Dam behavior and consequently, the correct modeling procedure. Also, studies have been indicator of suitable stability and safe position for Gelabar Dam.


For most of us, we are coming to the end of semester and into a period where, for some of us, we will be making decisions about whether or not to write up a refereed paper for the TASA conference for example. For higher degree students, this can be a difficult decision to make. It requires a bit of time away from your thesis and, depending on your supervisor, it can require a bit of negotiation. More importantly, it requires an understanding of the types of publishing that is important in your discipline as well as an understanding of exactly what you can publish from your thesis. So in our second instalment in our discussions of postgraduate issues, I will engage with a few of the key issues in negotiating this type of work and provide some advice on working smarter when publishing.


SK-2 borehole in Songliao Basin provides unprecedented geological materials for investigating the Early Cretaceous continental paleoenvironment and paleoclimate in northeastern China. The lacustrine successions of the lower Shahezi (K1sh) Formation at the depth from 4,542 to 5,695 m was systematically studied using environmental magnetism and cyclostratigraphy in this study. Magnetic analysis reveals an inverse correlation between magnetic susceptibility (MS) and lithological ranks in fine clastic sediments, with the highest values in mudstones and the lowest in sandstones. The main magnetism carriers in the lower K1sh are pseudo-single-domain (PSD) and/or multi-domain (MD) magnetite with minor presence of hematite. MS was used to further explore the genesis of the environmental and climatic variations through cyclostratigraphic analysis. Sedimentary cycles of 113 m, 34 m, 13 m and 6 m can be identified in the power spectrum, which were interpreted as long and short eccentricity, obliquity, and precession cycles, demonstrating the impact of astronomical cyclicity on sedimentary rhythmicity. Floating astronomical time scale (FATS) of 4,090 kyr and 4,148 kyr were established by tuning the inferred long and short eccentricity cycles to the artificial 405-kyr and 105-kyr orbital eccentricity curves respectively. The estimated sediment accumulation rate around 28 cm/kyr confirms the rapid deposition process within the faulted lacustrine basin. Based on this study, the lake level oscillations in Songliao Basin are assumed to be shaped by long and short eccentricity, precession and semi-precession cycles during Early Cretaceous. This study also indicates that the sand-mudstone alternations deposition in K1sh is most likely driven by the seasonal discrepancies of summer insolation during semi-precession periods.


Tailoring the optical response of metal nanoparticles by controlling their morphology is a key topic in the field of nano-optics. Here, a simple approach for the fabrication of tunable plasmonic nanostructures by nanosphere lithography is presented.


The huge ice jam dam flood years observation data on the Heilongjiang River Songhuajiang River and Nenjiang River indicate were analyzed,ice jam flood the many years occurrence at "two"river,happened in the same times,it's a small number of years occurrence at "three river"happened in the same times",and it's characteristic of occurrence at concentrated period.Before occurrence ice jam,precipitation above normal to the advantage of top lever in autumn.The winter was obviously process precipitation and rises temperature in ice-cut spring,was the mainly cause of the forming ice jam dam flood.


We report on a search for a new, short-range, spin-dependent interaction using a modified version of the experimental apparatus used to measure the permanent neutron electric dipole moment at the Paul Scherrer Institute. This interaction, which could be mediated by axion-like particles, concerned the unpolarized nucleons (protons and neutrons) near the material surfaces of the apparatus and polarized ultracold neutrons stored in vacuum. The dominant systematic uncertainty resulting from magnetic-field gradients was controlled to an unprecedented level of approximately 4 pT cm−1 using an array of optically-pumped cesium vapor magnetometers and magnetic-field maps independently recorded using a dedicated measurement device. No signature of a theoretically predicted new interaction was found, and we set a new limit on the product of the scalar and the pseudoscalar couplings gsgpλ2<8.3×10−28 m2 (95% C.L.) in a range of 5 µm <λ<25  mm for the monopole–dipole interaction. This new result confirms and improves our previous limit by a factor of 2.7 and provides the current tightest limit obtained with free neutrons.


The article is devoted to the research of crystallization of meanings and senses as a result of perception, understanding and transformation of information structures. The main characteristics of crystallization during the process of learning definitions and texts perception are presented. Degrees of semantic crystallization are designated.


Communication between cells of the central nervous system (CNS) and of the immune system is accomplished by a network of cytokines and growth factors. Certain cytokines and growth factors cause activation of microglia, contributing to inflammatory states in the CNS. Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) has numerous effects on microglia, ranging from induction of proliferation to changes in morphology. GM‐CSF is also a growth factor for cells of the myeloid lineage, and the signal tranduction induced by GM‐CSF in these cells has been extensively studied. Most notably, the importance of the Jak/STAT and MAP kinase pathways in mitogenesis has been shown in many different systems. We show here that primary microglia and a microglia cell line, BV‐2, have a Jak/STAT expression pattern and GM‐CSF inducibility similar to that of monocytes and macrophages. Primary microglia and BV‐2 cells expressed identical Jak/STATs: Jak1, Jak2, Jak3, Tyk2, STAT1α/β, STAT3, STAT5A, STAT5B, and STAT6. In addition, GM‐CSF induced Jak2, STAT5A, and STAT5B in BV‐2 cells, as it does in monocytes and macrophages. Immunocytochemical analysis showed that STAT5 translocates to the nucleus following GM‐CSF stimulation of microglia. We also found the MAP kinases, ERK1 and ERK2, to be phosphorylated in microglia and BV‐2 cells following induction by GM‐CSF. Jak2, STAT5A, STAT5B, and ERKs are known to be important in controlling cellular proliferation. Drugs that block these pathways may become tools to control inflammation in the CNS by limiting microglial proliferation. GLIA 26:344–352, 1999. © 1999 Wiley‐Liss, Inc.


Abstract This article presents a double interrupt and frequency-doubled angle compensation control method based on the minimum inductance characteristic of high-speed motor. Moreover, this article designs a proportional-integral-integral-proportional (PI-IP) control structure to realise that the control system can track the d-axis current step response within 330µs based on the high response characteristic design requirements of the high-speed motor. The effectiveness of this method has been verified by simulations and experiments. The proposed controller has a better ability to track the speed instruction in the case of mutations of the external load. It also has an excellent robustness to respond to the speed when the rotational inertia is changed. The authors design a system to test a high-speed motor whose rated power is 100 W and rated speed is 17,000 rpm. The results show that the method above can realise the high response and high precision servo control of high-speed motor without delay effectively.


Aiming at the issue of mining frequent moving patterns with two dimensional attributes including locations and time in sensor networks,a novel algorithm named OMP-mine is proposed.OMP-mine is based on a novel data structure named OMP-tree and a scheme of conditional search.The OMP-tree can efficiently store large numbers of original moving patterns compactly and the method of conditional search can efficiently narrow the search space.OMP-mine adopts the idea of pattern growth,recursively fetches frequent prefix patterns from the conditional pattern bases directly,and joints the suffix to make a pattern grow.Simulation results show OMP-mine can efficiently discover frequent moving patterns with two dimensional attributes in sensor networks and decrease its time complexity and space complexity simultaneously.


PURPOSE
To evaluate prognostic factors for patients with renal cell carcinoma (RCC) who had undergone surgical resection.

PATIENTS AND METHODS
We analyzed data from 371 patients with RCC who had undergone surgical resection. Prognostic factors were identified from clinical and pathological data using univariate and multivariate analysis.

RESULTS
When we analyzed all patients including lymph node metastasis, multivariate analysis showed that only pN factor was an independent prognostic factor. We then analyzed 359 patients without lymph node metastasis, and the presence of symptoms, pT, grade, IFN and venous involvement were considered significant. However, pT (pT1 vs pT2-4), tumor grade and presence of symptom were judged to be independent prognostic factors by multivariate analysis. When the patients were stratified according to the tumor size (2.5, 4, 7 cm), a significant difference in disease specific survival was found by 4 and 7 cm, but not by 2.5 cm.

CONCLUSIONS
The current TNM staging accurately predicts patient survival. Tumor grade is also an important prognostic factor for patients with RCC.


Received 8 March 2015; received in revised form 27 April 2015; accepted 27 April 2015ABSTRACTThe grinding and furbishing process as the finishing process for molds include the works suchas the grinding, buffing, lapping and polishing among others. A finishing tool unit is applied tothis finishing process for the burr, lapping, polishing and others of molds. A finishing tool unitcan carry out the flexible machining, depending on the machining allowance for objects to becut on the basis of the instrumental driving mechanism which enables the up, down, left andright floating, which is applied in link with the dedicated cutters and robot machining systems.This study selected the shape to increase the rotatory force of an impeller when air is dis-charged during the driving of a finishing tool unit, and reflected it to the impeller designing. Inaddition, the study analyzed each flow velocity and pressure distribution per air pressurizationvalue and finally analyzed the rotating torque to suggest the optimal conditions in designingimpellers.Key Words: Air impeller, CFD analysis, Design, Finishing tool unit


THE CORRELATION OF PAVEMENT PERFORMANCE WITH SOIL TESTURE IS SHOWN BY PERFORMANCE SURVEYS, AND THE NEED FOR INCREASED USE OF SEMI-GRANULAR AND GRANULAR MATERIALS FOR EMBANKMENTS, SUBGRADES, AND BASE COURSES IS INDICATED. THE IMPORTANCE OF OBTAINING COMPACTION IS EMPHASIZED, PARTICULARLY WHERE SEMI-GRANULAR MATERIALS ARE EMPLOYED. /AUTHOR/


The lack of proper peer-reviewed medico-judicial processes, which rendered healthcare workers vulnerable in foreign countries, the ethics of boycott politics, and the real political clout of top private business emerged as major themes in the 9-month saga of Professor Cyril Karabus.


The δ‐target method proposed recently [Chem. Phys. Lett. 235, 309 (1995)] was shown to significantly simplify the task of optimal control of molecular localization. The present paper is intended to study the application of the δ‐target technique to a practically interesting case of a diatomic molecule including rotation. Illustrative numerical examples are presented for the molecules NO and Na2. The δ‐target method is shown to provide good control when the rotational temperature is not too high. The optimal control solution is very robust and insensitive to small changes in the potential curves and transition dipole moment functions. It is shown that the field obtained within the linearized δ‐target optimal control technique can be successfully used in the nonlinear regime. The possibility of extending the δ‐target technique is considered for treating strong field nonlinear optimal control tasks. The computational advantages of the method are discussed.


: One of the unavoidable issues of contemporary societies is traffic, which results in unfavorable outcomes like impeding emergency vehicles' access to destinations, wasting time, and increasing the likelihood of accidents. The utilization of Internet of Things (IoT) in managing traffic signals can greatly enhance the flow of traffic and alleviate road congestion. A new method is suggested in this article to identify emergency vehicles and control traffic signals accordingly. To control traffic lights more efficiently, the use of IoT approaches is implemented where sensors such as surveillance cameras capture real-time traffic information for the smart traffic signal management system. To guarantee that emergency vehicles reach their destination with minimal delays, the system is created to provide a clear path.


Let be a representation space of a Lie group , a differential form of the first degree on and a field of closed convex cones on . Problem 1 is the minimization of the integral of the differential form along curves which satisfy certain boundary conditions and are solutions of the differential inclusion . This problem is assumed to be equivariant in the sense that the field of cones and the differential form are invariant under the action of . For Problem 1 the author introduces the concept of a totally extremal manifold, which is an analogue of the concept of a totally geodesic manifold in a Riemannian or Finsler space. Some theorems are proved on totally extremal manifolds for fundamental representations of Lie groups. These theorems are used along with techniques developed in previous papers by the author to construct a synthesis of optimal trajectories for some multidimensional equivariant problems.Figures: 4. Bibliography: 13 titles.


Both currently and in the aftertime,the matter that we must face is to boost the ability of government,because it is essential to the reform and opening to the outside and modernization drive.The following phenomena that now exist in administration restrict enhancing the ability of government:authority descends,corruptness spreads,function is not rational,the mechanism of decision_making and performance is not perfect.Administration by law can eliminate these.It may well boost up the authority of government,contain corruptness in administration,legally prescribe the function of government,shape scientific and effective mechanism for decision_making and performance.


Techniques which use a spring to supply the bias force to actuator are well adopted since they are inexpensive and simple to construct. In this work it was design an actuator concept using bias-type device technique, which comprises two coils that mutually push against each other to supply the stroke. For the coils springs, it was used a wire of NiTi shape memory alloys (SMA) and a wire of 400 grade maraging steel as construction materials.


Students commonly judge that cell metabolism topic is arduous since they only listen to their teacher and memorizing concept without a deep comprehension. Other than that, a direct explanation could not enhance the students' science process skills. Thus, this research intended to analyze the differences of the content-analysis and science process skills between the students experiencing a learning that oriented to scientific independence (experimental class) and those joining a direct learning (control class). The materials taught in both classes were cell metabolism. This study employed the quantitative of the quasi-experimental method. The research object was the students learning Biology. The students joining a scientific independence-based class were able to answer questions requiring analytical thinking. The relationship of the students' scientific independence towards the content analysis and science process skills was seen on the test. Based upon the statistical data analysis, the correlation significance was 0,038<0,05. Therefore, it concluded that there was a very significant correlation between the students' scientific independence towards the content analysis and science process skills.


It was shown that the initial detection characteristics were maintained for a long period in a nuclear radiation detector constructed with a mercuric iodide (HgI2) crystal grown by the vapor transport method of the conventional and simple static sublimation. Performance tests of this HgI2 nuclear radiation detector were carried out to see if it could be theγ-ray measuring device to operate in a nuclear reactor at room temperature. In spite of the extremely small size of its element (1.95mmmm2×0.7mmt), the detector under


The front-line delivery of benefits, tax credits and employment services has changed significantly. Emerging problems in the new systems have been subject to intense scrutiny. Despite recent improvements, advocacy and user organisations remain critical of the impact on disadvantaged users. Key areas highlighted are the system's complexity, lower than anticipated take-up rates, poorly developed ICT systems, weak coordination of services, and reduced options for face-to-face contact. This review looks at recent evidence on both problems with service delivery and potential solutions. The report: • describes briefly the new systems; • presents findings from a literature review and from qualitative research, identifying service delivery problems and users' views of what they want from the system; • proposes some future developments in the delivery of the welfare system;and • considers key themes where further research is needed.


The present invention relates to co-production process of a carboxylic acid and (or) a derivative thereof containing formic acid, at least two carbon atoms. According to the method of the present invention, (a) by screen transesterification of formic esters of the formula (I) with at least two carboxylic acid of formula (II) having a carbon atom acid to form a carboxylic acid ester of formula IV to formic acid and the corresponding of formula (III) and; (B) to carbonylation at least a portion of the carboxylic acid ester of formula (IV) formed in step (a) to form a carboxylic acid anhydride of formula (V) corresponding to.


This study reexamines the validity of long-run purchasing power parity (PPP) hypothesis using a battery of panel unit root tests for 11 developing countries in Africa over the period 1980-2007. Based on the conventional panel unit root tests, we found evidence that the monthly real exchange rates in these countries were mean reverting. By contrast, the series-specific unit root test proposed by Breuer "et al." (SURADF) reveals that only six of the 11 RERs series were stationary using the US dollar as reference currency. Additionally, our results reveal that there is stronger evidence of the parity condition with the Rand-based rates than in the other currency-based rates like the US dollar or Euro. We conclude that PPP holds in some, but not all, of the African countries according to the SURADF tests. Copyright (c) 2010 The Authors. Journal compilation (c) 2010 Economic Society of South Africa.


Graphene is a surprisingly good conductor. Despite its direct exposure to various sources of disorder (charged impurities, non-uniformity of the substrate, etc.), graphene remains conductive even when the nominal concentration of both electron and hole carriers drops to zero - the neutrality point (NP). Theory of the minimal conductivity of graphene is an outstanding challenge because of the non-perturbative nature of disorder at the NP and the still unsettled question of which type of disorder is really dominant. Here, we report on our progress towards analytical solution of the model of graphene subject to the disorder in the form of in-plane charged impurities. Our approach is asymptotically exact for graphene in high dielectric-constant environment where Coulomb interactions of electrons with impurities and electrons with each other become weak. We show that screening of the impurity potential is nonlinear, producing a fractal structure of electron and hole puddles. Statistical properties of this density distribution as well as the charge compressibility of the system are calculated in the leading-log approximation. The minimal conductivity is shown to depend logarithmically on the dielectric constant. We compare our results with other theoretical works and current experiments. Our (cid:12)ndings suggest that in real samples charged impurities are either not exactly coplanar with graphene, or are correlated, or are not the only source of disorder. This work is supported by the NSF.


Salvage surgery is always a challenging choice and must even more fulfil both oncologic requirements and quality-of-life issues. In head and neck patients, the most important goals are pain relief, preservation of breathing and deglutition, acceptable cosmetic results, and a sufficient quality of the residual life. When surgery is still considered an option, a safe, quick-recovering, and function-saving technique should be chosen. The author's experience and an illustrative case report are described.


The wide bandgap semiconductors Silicon carbide and gallium nitride have been studied by Raman scattering, photoluminescense, and infrared absorption. Raman scattering studies determined crystalline quality and polytype of bulk and thin film samples at room temperature to detected and/or identify impurity centers and structure related defects and their role on the electronic properties of the materiais. Infrared absorption spectroscpopy was used to measure the binding enrgy of donors and their concentration.


A new method which uses a neural optimisation network to solve the two-dimensional (2-D) layout compaction problem is proposed. The problem is formulated as a mixed integer linear programming (MILP) problem with the value of each integer variable being 0 or 1. A special MILP neural optimisation network is used to attack the problem. >


JS 1 is the water soluble polysaccharide isolated by alkaline from Hippophae rhamnoides L.. By means of IR, GC, GC MS, 13 C NMR, periodate oxidation, Smith degradation, mathylation analysis and partial acid hydrolysis etc., JS 1 is a kind of neutral heteropolysaccharide with many branches. It consists of Ara, Xyl, Gal and Glc in a molar ratio of 1∶6∶12∶4 in turn. Its basic structure consists of a main chain composed of(1→3) linked Xyl,(1→3) linked Gal and (1→3) linked Glc residues with side chains of (1→5) linked Xyl, (1→4) linked Gal and (1→6) linked Gal residues, attached to C 2 of Xyl and C 6 of Gal residues in the main chain.


Objective:To optimize preparation technology for Flow Yinpian of Cirsium setosum,and compare with traditional Yinpian of C.setosum.Method:With the mass fraction of linarin as index,orthogonal method was used to investigate influence of grinding degree,the amount of water,roll pill speed on preparation technology;TLC,HPLC,SD-IR were used to compare traditional Yinpian with Flow Yinpian of C.setosum.Result: Optimized preparation technology was as following:grinding degree 80 mesh,the amount of water 1.8 times,roll pill speed 300 r · min-1,mean particle size of prepared Flow Yinpian of(1.94±0.20) mm,roundness of 9.09-27.7,bulk density 0.394 3 g · cm-3,true density 0.655 7 g·cm-3,mean hardness 6.2 N,mean friability 0.30%.Their TLC were similar,the content of linarin was 0.64% in traditional Yinpian,while it was 0.72% in Flow Yinpian.Decoction curve of them was close,IR spectroscopy of their decoction was nearly the same.Conclusion: Traditional Yinpian and Flow Yinpian of C.setosum was reciprocity in pharmacy,they could substitute for each other.


The aim of the study was to evaluate the effectiveness of polyherbal formulation on cataract development in streptozotocin-nicotinamide-induced diabetic rats. Diabetes was induced by streptozotocin (65 mg/kg, ip) and nicotinamide (90 mg/kg, ip). The diabetic rats were orally treated with polyherbal formulation (therapeutic dose, 28.71 mg/kg and 2×therapeutic dose, 57.42 mg/kg) and metformin (150 mg/kg), for 12 weeks. Serum glucose levels, body weight, histopathology of pancreas were used to evaluate the antidiabetic activity while the histopathological study of eye and protein content in lens were used to evaluate the protective effect of polyherbal formulation on cataract development. The progression of cataract in rat lens was observed with a slit-lamp biomicroscope. A daily treatment of polyherbal formulation for 12 weeks resulted in significant (p<0.05) decrease in serum glucose level, body weight and improved protein content in the lens. It also delayed the incidence of cataract in diabetic rats. The histopathological study showed that there was regeneration of pancreatic β-cells. The results observed with polyherbal formulation were found to be comparable to those obtained with metformin. Results suggested that the polyherbal formulation possessed antidiabetic activity and prevented cataract development.


This paper discusses about some technology breakthroughs to help solve the difficulties that have been clogging the popularity of 3D Stereo. We name this 3DHiVision (3DHV) System Solution. With the advance in technology, modern projection systems and stereo LCD panels have made it possible for a lot more people to enjoy a 3D stereo video experience in a broader range of applications. However, the key limitations to more mainstream applications of 3D video have been the availability of 3D contents and the cost and the complexity of 3D video production, content management and playback systems. With the easy availability of the modern PC based video production tools, advance in the technology of the projection systems and the great interest highly increased in 3D applications, the 3D video industry still remains stagnant and restricted within a small scale. It is because the amount of the cost for the production and playback of high quality 3D video has always been to such an extent that it challenges the limitations of our imagination. Great as these difficulties seem to be, we have surmounted them all and created a complete end-to-end 3DHiVision (3DHV for short) Video system based on an embedded PC platform, which significantly reduces the cost and complexity of creating museum quality 3D video. With this achievement, professional film makers and amateurs as well will be able to easily create, distribute and playback 3D video contents. The HD-Renderer is the central component in our 3DHV solution line. It is a highly efficient software capable of decrypting, decoding, dynamically parallax adjusting and rendering HD video contents up to 1920x1080x2x30p in real-time on an embedded PC (for theaters) or any other home PC (for main stream) with the 3.0GHz P4 CPU / GeForce6600GT GPU hardware requirements or above. And the 1280x720x2x30p contents can be performed with great ease on a notebook with 1.7GHz P4Mobile CPU / GeForce6200 GPU at the time when this paper is written.


Review of Clyde S. Kilby, A Well of Wonder: Essays on C.S. Lewis, J.R.R. Tolkien, and the Inklings. Edited by Loren Wilkinson and Keith Call (Paraclete Press, 2016) by Joel D. Heck.


As libraries move from paper subscriptions to online access the publisher is finding that their traditional subscription business model also has to develop and change. These changes, whilst offering new opportunities, can also be a threat to the publisher. This paper will present on the challenges now presented to Blackwell Publishing in this fast-changing, online-arena and will discuss how the new challenges of the online environment can be turned into opportunities both for the publisher and the consumer alike. This paper will examine how the move to online only effects the way that content is displayed to different groups of readers; how the traditional annual subscription fee model is being replaced by more sophisticated pricing model negotiations; and finally how the battle for readership ensues after each sale is made as usage data becomes the true deciding factor of whether a journal is renewed or cancelled.


New metal complexes of some transition metal ions [Fe(III) , Co(II) , Ni(II) and Cu(II)] of two previously prepared ligands HLI=(P-methyl anilino)- P-methoxy phenyl acetonitrile and HLII =(P-methoxy anilino)-P- methoxy phenyl acetonitrile were synthesized. The two ligands were prepared by Strecker's procedure which included the reaction of Pmethoxybenzaldehyde with p-toluidine and P-anisidine respectively. The structures of the new metal complexes were characterized by atomic absorption , i.r and U.V.-visible spectra . Magnetic susceptibilities and conductivity measurements in DMF of metal complexes were also studied. These ligands coordinate as abidentate molecules through nitrogen atoms of amino group and nitrile group except the complex C6 of the   ligand HLII  coordinates as monodentate with Ni(II) ion through nitrile group only.


Motivated by the remarkable experimental control of synthetic gauge fields in ultracold atomic systems, we investigate the effect of an artificial Rashba spin-orbit coupling on the spin polarization of a two-dimensional repulsive Fermi gas. By using a variational many-body wavefunction, based on a suitable spinorial structure, we find that the polarization properties of the system are indeed controlled by the interplay between spin-orbit coupling and repulsive interaction. In particular, two main effects are found: 1) The Rashba coupling determines a gradual increase of the degree of polarization beyond the critical repulsive interaction strength, at variance with conventional 2D Stoner instability. 2) The critical interaction strength, above which finite polarization is developed, shows a dependence on the Rashba coupling, i.e. it is enhanced in case the Rashba coupling exceeds a critical value. A simple analytic expression for the critical interaction strength is further derived in the context of our variational formulation, which allows for a straightforward and insightful analysis of the present problem.


Recently, several simple and cost-effective pedestrian navigation systems (PNS) have been introduced. These systems utilized accelerometers and gyros in order to determine step, stride and heading. The performance of the PNS depends on not only the accuracy of the sensors but also the measurement processing methods. In most PNS, a vertical impact is measured to detect a step. A step is counted when the measured vertical impact is larger than the given threshold. The numbers of steps are miscounted sometimes since the vertical impacts are not correctly measured due to inclination of the foot. Because the stride is not constant and changes with speed, the step length parameter must be determined continuously during the walk in order to get the accurate travelled distance. Also, to get the accurate heading, it is required to overcome drawbacks of low grade gyro and magnetic compass. This paper proposes new step, stride and heading determination methods for the pedestrian navigation system: A new reliable step determination method based on pattern recognition is proposed from the analysis of the vertical and horizontal acceleration of the foot during one step of the walking. A simple and robust stride determination method is also obtained by analyzing the relationship between stride, step period and acceleration. Furthermore, a new integration method of gyroscope and magnetic compass gives a reliable heading. The walking test is preformed using the implemented system consists of a 1-axis accelerometer, a 1-axis gyroscope, a magnetic compass and 16-bit microprocessor. The results of walking test confirmed the proposed method.


The performances of a feedforward artificial neural network trained with backpropagation on the task of peak-picking of nuclear magnetic resonance spectra are probed on experimental spectra of two different proteins. The performances of the network are comparable with those of a human expert.


We present a combined imaging system of positron emission tomography (PET) and electron paramagnetic resonance imaging (EPRI) developed for assessing tumor hypoxia. Tumor hypoxia has been known to be resistant for cancer treatment such as radiation therapy. Therefore, precise quantitative measurement of tumor hypoxia is important for effective cancer treatment planning in radiation therapy. In clinic, PET imaging by using 18F-fluoromisonidazole (F-MISO) have been performed to delineate tumor hypoxia. However, the effectiveness of PET imaging based hypoxia targeting in radiation therapy was not yet firmly established. EPRI is a non-invasive imaging method capable of measuring the partial pressure of oxygen (pO2) in tissue precisely. However, EPRI is not available for clinical use currently. The combined imaging system is to use EPRI as a gold standard to measure the pO2 in hypoxic tumor in animal, and aims to evaluate the validity of PET imaging in tumor hypoxia by simultaneously acquired EPRI. The PET component of the combined system, which was originally developed as an insert for MRI, consists of total 14 detector modules. Each PET detector module uses of 8x4 LYSO arrays (3x3x10 mm3) coupled to Hamamatsu S13361 MPPC arrays (3.2 mm pitch). The detector modules are encased in a cylindrical plastic holder with 60 mm inner diameter and 115 mm outer diameter in a ring configuration. The axial field of view of the PET is 25.6 mm. The EPRI component of the system is built with two permanent magnets (25 mT), three gradient field coils for spatial encoding (the maximum 15 mT/m) and a RF resonator. The PET is installed to fit into the two EPR magnets (12 cm distance apart) so that the PET detector center is aligned to the magnet center. The compatibility of two imaging modalities were tested by using a 22Na point source and imaging phantoms. Animal imaging with F-MISO and FDG were also performed by running the PET/EPR simultaneously. Initial imaging results are reported.


#### What you need to know

A doctor consults with a 69 year old patient and notes that she seems distant and sad. It is three months since her partner died. When the doctor asks how she is managing she says the house feels empty without him and she feels low. She no longer sees any reason to cook and struggles to clean. She longs for companionship but refuses invitations from her friends because being with them makes her miss her partner. Her grandchildren are a pleasure but they ask about grandpa, so she doesn't want to see them. Tearfully, she talks of dreading her future.

A woman presents with sleep disturbance and severe headaches a month after her son died by suicide. She believes that a good mother would have saved him and she is plagued by guilty self-recrimination. She seems irritable and has been fighting with her husband. She has been finding it very hard to care for her two living children.

Loss of a loved one can be very painful. When seeking support, some people turn to their doctor. Because of their pivotal role in the community, physicians can provide excellent support for bereaved people and can often direct them to additional resources.1 Medical professionals who see bereaved patients …


Fuzzy inference systems for diagnosis of diabetes are developed using Mamdani-type and Sugeno-type fuzzy models. The outcome obtained by two fuzzy inference systems is evaluated. This paper summarizes the essential variation among the Mamdani-type and Sugeno-type fuzzy inference systems. MATLAB fuzzy logic toolbox is used for the simulation of both the models. This also confirms which one is a superior choice of the two fuzzy inference systems for diagnosis of diabetes.


In this study E. Bourguignon takes up a thesis advanced in 1937 by Herskovits in which the expression &dquo;socialized ambivalence&dquo; (ambivalence socM~see) was used to describe a particular adjustment to a civilization in which the ancestral elements have never been completely assimilated. The individual Haitian, in the face of rapid and radical change, is said to experience ambivalence in his attitude and behavior. This ambivalence is &dquo;socialized&dquo; to the extent that it is common to all, and not an idiosyncratic trait. Herskovits subsequently abandoned this concept which the author thought worthy of further study. In her present study, she attempts to reexamine this concept and divides her study in the following way: ( d ) Illustration of the concept of ambivalence by means of a case presentation, and (2) discussion as to the validity of applying this concept to the Haitian elite.


Summary Tripartite interactions among phytophagous insects, pathogens and their host plants provide insight into the role of host physiology in determining susceptibility to attack. American beech (Fagus grandifolia) often is simultaneously attacked by beech scale (Cryptococcus fagisuga), one or more Neonectria pathogens and Xylococculus betulae that can result in beech bark disease (BBD). Additionally, beech is frequently infected by heartrot-decay fungi. Cursory observations in 2011 suggested that beech scale and Neonectria lesion densities were lower and greater, respectively, on trees with decay. In 2012, digital image analysis was used to quantify densities of these organisms on 123 beech from the Adirondack region of New York. Three groups of study trees (n = 41) were used: Inonotus glomeratus-infected, Phellinus igniarius-infected and non-decay trees. Trees infected by decay pathogens supported lower densities of beech scale and higher densities of Neonectria. Densities of X. betulae did not significantly vary among decay groups. These results may be explained by decay-induced changes in host physiology. Additional work is needed to elucidate the potential role of host bark chemistry in the BBD complex.


Fuzzy multiple criteria decision making (FMCDM) problem is an important issue in the field of decision making. Traditional weighted method is on the basis of disputed arithmetic operation and comparison operation on fuzzy numbers, the accuracy of decision is doubtful. In this paper, a new method is proposed to solve the FMCDM problem based on the generalized fuzzy numbers and power average operator. This method avoids the use of the disputed operation on fuzzy numbers. Within this method, a new power average operator is developed to help the aggregation of generalized fuzzy numbers. An illustrative example shows the effectiveness of the proposed method.


Based on hydrological data from the 4 stations on the Beijiang main stream, the annual maximum peak flow series were constructed in this paper. The linear regression, Mann-Kendall(M-K) methods, empirical mode decomposition(EMD) and rescaled range analysis(R/S)were used to find out the variation law of the series and the linear correlation was used to analyze the impact factors preliminarily. The results show that there is insignificant change trend in the series, and there exists abruptly jumping points. But all the series have the fluctuating cy-cles of 4 to 6 a and 8 to 10 a. The series for the 4 stations all get long-term memory characteristics so that the future tendency of the series is indistinctive. The result of the linear correlation shows that South Asian summer monsoon is the main factor to the series and sunspot may affect the cycle of the series.


Encouraging use of public transit is one important way to reduce energy consumption and counter climate change. In my research on the design of Swedish travel centers, I have studied the transit stations for the planned "West Link," an underground railway tunnel through Gothenburg that will increase the capacity for commuter traffic. I ask how one might design public-transport spaces that incorporate safety, comfort, unambigu-ous orientation, and aesthetic values. A thorough answer to this question might help de-signers and planners to create more sustainable, user-friendly urban spaces.


LITURGICAL RENEWAL and clerical celibacy are two contemporary topics that direct attention to the Church of the fourth century. The form of the Eucharist then, its frequency, the hour and place of celebration, and its influence on piety—each of these is advanced as a normative guide for the reform of the liturgy today. Among these, the frequency of Mass has become an essential part of a popular thesis about the first laws of clerical celibacy. The supposition is that the clergy of the Latin Church began to celebrate Mass every day at the end of the fourth century. By joining this to the conviction that ritual purity was everywhere observed, some scholars feel they have accounted for the legislation of absolute continence for married clerics in major orders: married clerics who abstained from sexual intercourse the day before the celebration of the Eucharist would automatically be bound to observe total continence if they said Mass every day. The force of this simple argument depends completely upon the validity of each of its components: that clerics observed ritual purity; that daily Mass appeared precisely then; that this


Digital proof is a modern manner of the front printing at present. This paper introduced internal actuality ,the conception, the application and developing status of digital proof of the front printing technology and emphatically discussed the seven characteristics of digital proof different from traditional proof.


Currently lending is one of the effective tools to improve living conditions of the citizens of the country, the region and the city, which has recently become even more important. The paper assessed the housing affordability index using credit by county from 2006 to 2011 at the primary and secondary markets, as luxury housing and standard housing.


A way of external heating and hot conduct was always used in traditional tyre vulcanization, the way had some shortcoming of big temperature gradient and slow heating rate, and effected on the tyre vulcanization quality.Some researchers and research units were seeking more reasonable vulcanization technology for solving this problem, and obtained same temperature on the insideoutside of the green tyre to develop tyre vulcanization quality. The preheating technology of the green tyre before vulcanization was studied and tested by using microwave heatng way. It was indicated that the shortcoming of the inside heating-up slowness and the outside quickness was overcomed, and the vulcanization quality and efficiency were both developped by using microwave preheating technology.


Experiments have been performed to gain insight into the response of a surface buoyancy flux-driven circulation to a localized input of mechanical energy. The mechanical energy is provided via a surface stress imposed along the same boundary as the buoyancy forcing. Both the case of the surface stress running concurrently to the sense of the circulation imposed by the buoyancy forcing as well as against it are explored. The nondimensional ratio of mechanical to buoyancy forcing, S[delta]f, is used to distinguish between distinct regimes that exist for each experiment set, and is maintained at O(1). In the case where surface buoyancy forcing and surface stress support a circulation in the same direction on the upper boundary, the overarching result is that the surface stress induces small-scale turbulence once the shear is strong enough to overturn the local stratification, corresponding to the threshold of S[delta]f > 0.42. The experiments are compared to numerical results of the recycling box model of Hughes et al. (2007), with varying mixing in the vertical. Experiment measurements agree satisfactorily with theory, and outline the response of the system to various mixing depths. If the stress is in competition with the buoyancy forcing on the upper boundary, experiments reveal a suite of regimes in S[delta]f in which the flow response varies. Briefly, full-depth buoyancy-driven convection persists for S[delta]f 0.87, a two-cell circulation develops, featuring a shallow stress-driven cell overlying a deeper buoyancy-driven cell. The experiment results are applicable in the oceanographic context to imposed wind stress on the ocean surface simultaneously subject to surface buoyancy fluxes


Objective In order to deal with the acute and chronic poisoning cases of tetramine,it is very necessary to establish a qualitative and quantitative method for detecting tetramine by Gas chromatography-mess spectrum( GC-MS / MS) with high sensitivity and good accuracy. Methods The target compound of tetramine was concentrated after being extracted from samples with ethyl acetate,and then was analyzed by GC-MS / MS. Three characteristic ions of tetramine( m / z 131. 9,m / z 211. 9,m / z 239. 9) as the parent ions were collided with different voltage,thereby their daughter ions could be acquired repectively.We selected an ion pair( 239. 9 →41. 9) which has higher response value as quantitative iron pairs from 5 ion pairs( 239. 9 →41. 9; 239. 9→132; 211. 9→131. 9; 211. 9→92; 131. 9→42. 1),the other ion pairs as identification iron pairs. Detection was carried out by multiple reaction monitoring( MRM). Results The method showed a positive correlation in the concentration range of 0. 003 μg / ml ~ 2. 0 μg / ml of tetramine,r = 0. 999 6. The recovery rate was 99. 0%,and the relative standard derivations was 5. 1%. The detection limit of liquid sample was 0. 000 03 μg / ml( 0. 000 2 μg / ml for blood sample),and the detection limit of solid sample was 0. 000 1 μg / g. Conclusion This establishedmethod has a high sensitivity and accuracy,and it has a lower detection limit. It's suitable for the detection of trace amounts of tetramine.


This paper presents a distributed network management system which provides a means to manage communication network for distributed systems. For efficient network management, the multi-level domain approach has been used. Management function (Configuration, Fault, Performance management) is distributed in each management domain. The management system was composed of several elements. Some of those were previously implemented in the project of the single level multi-domain network management system. The integration of different networks which have different network management schemes can also be achieved with the distributed network management system. The object-oriented distributed database was chosen for management information base (MIB). We finished the design of the system and are in the middle of it implementation in the environment of distributed campus network (CNUNet).


ABSTRACT In previous editions of the DAFX [1, 2] we presented a method for the analysis and the resynthesis of voiced sounds, i.e., of sounds with well defined pitch and harmonic-peak spectra. In a following paper [3] we called the method Fractal Additive Synthesis (FAS). The main point of the FAS is to provide two different models for representing the deterministic and the stochastic components of voiced-sounds, respectively. This allows one to represent and reproduce voiced-sounds without loosing the noisy components and stochastic elements present in real-life sounds. These components are important in order to perceive a synthetic sound as a natural one. The topic of this paper is the extension of the technique to inharmonic sounds. We can apply the method to sounds produced by percussion instruments as gongs, tympani or tubular bells, as well as to sounds with expanded quasi-harmonic spectrum as piano sounds. 1. INTRODUCTION The FAS method allows one to separate the stochastic components of voiced sounds from the deterministic ones and to resynthesize both of them separately. Both these components are important from a perceptual point of view and contribute in different ways to a high-fidelity resynthesis. The deterministic part contains the structure of the sound. The stochastic part contains the real-life flavor, i.e. all the information relative to the random deviations with respect to a strictly deterministic representation of sounds. This part is necessary in order to avoid an "electronic-like" synthetic sound. In [4] we demonstrated that the wavelet transform in its harmonic extension, i.e., the Harmonic-Band Wavelet Transform (HBWT) is a "natural" tool to separate, decompose and resynthesize both the deterministic components and the noisy sidebands of the harmonic spectral peaks. This decomposition allows one to represent the different components of the sound by means of a restricted set of parameters. These parameters, different for the deterministic and the stochastic parts, correspond to the two models that make the FAS an interesting method both for sound synthesis/processing and for data compression in the context of Structured Audio. The new result that we present in this paper is the extension of the method to the inharmonic case. Our previous HBWT model was confined to the harmonic spectrum case. The time-frequency plane tiling was strictly harmonic. This is a major limitation and makes the method not usable for a large class of sounds, for instance all the sounds produced by percussive instruments. The spectra of many of these instruments show relevant peaks (see Figure 1). These peaks are the partials or deterministic components of the sound and can be sinusoidally modeled. These partials also show an approximately 1/


The emergence of multi-core architectures makes it essential for optimizing compilers to automatically extract parallelism for large scientiÃ"¨Åc applications composed of many subroutines residing in different Ã"¨Åles. In lining is a well-known technique which can be used to erase procedural boundaries and enable more aggressive loop parallelization. However, conventional in lining cannot be applied to external libraries where the source code is not available, and when overly applied, it can degrade the effectiveness of compiler optimizations due to excessive code complexity. This paper highlights some obstacles we encountered while applying conventional in lining combined with automatic loop parallelization using the Polaris optimizing compiler and presents a new approach, annotation-based in lining, to effectively overcome these obstacles. Our experimental results show that the annotation-based in lining approach can eliminate negative impact of conventional in lining while enhancing the effectiveness of interprocedural parallelization for a majority of applications from the PERFECT benchmark suite.


In this work, electron temperature was measured with both the asymmetric double Langmuir probe (ADLP) and the single Langmuir probe to investigate the reliability of the ADLP on the electron temperature measurement in multi-temperature Maxwellian plasmas. A series of I–V traces of the ADLP were obtained at various plasma conditions with different area ratios and analyzed with different methods including conventional ADLP analysis and two-temperature Maxwellian fitting with results measured by a single planar Langmuir probe analyzed with three-temperature Maxwellian fitting as reference. The measured Te of the ADLP is found to reflect that of the temperature of the degraded primary electrons when the area ratio of the probe tips is close to ∼16 and approaches the real effective electron temperature as the area ratio increases to a value of ∼30% higher than that measured by a single Langmuir probe, which occurs even when the area ratio is higher than the flux ratio of electrons and ions entering their respective sheaths. This effect is consistent with the distortion effect of Langmuir probe I–V traces caused by the presence of hotter electron species, which was computationally reconstructed and agreed well with the experimental observations. This result implies that an area ratio, possibly ∼20 times much larger than what was conventionally assumed, is needed for an ADLP to be reliably treated as a single Langmuir probe in practical settings, where electron energy distribution functions of plasmas are generally expected to be multi-temperature Maxwellian. This effect is also analogous to the current balance between a single Langmuir probe and the device wall, implying that this effect would also affect the application of the single Langmuir probe in plasmas, where the ion loss to the device wall can be reduced, such as plasmas in miniaturized devices, strong magnetic fields, or a highly ion-neutral collisional environment.


This paper presents the design, manufacturing and testing result of a 2 + 3 T high field MgB$_2$conduction-cooled solenoid magnet demonstrator. The prototype almost reached 2 T at 10 K inside a homogeneous background field of 3 T produced by a NbTimagnet. The demonstrator was wound with 1.6 km of Columbus ex-situ React and Wind (R&W) conductor. The mechanical design of the prototype is presented including the homogenization of the mechanical properties of the composite conductor. The Von Mises equivalent strain calculated after both cooling and energizing conditions is below the conductor strain criteria of 0.4%. In order to obtain the required magnetic field, three length of wires were linked together by two resistive junctions of approximately 150 n$\Omega$ each. The heat generated by the junctions was extracted by several heat sink apparatus. The different apparatus designed for the thermalization of both the junctions and the magnet are presented. Prior to the testing of the demonstrator, the conductor used for the prototype was tested. The results of these tests are compared to the current measurement of the demonstrator and no current degradation of the conductor wound is evidenced, proving the good handling of the wire during all the manufacturing steps and testing phase.


The two scenes representing the consecration of Saint Amand as a bishop and later his investiture as Bishop of Maastricht1 (Figs. 1, 2) are part of a series of thirty-two pictures illustrating the eighth-century text of the saint's life. They belong to a manuscript written and painted at the end of the eleventh or beginning of the twelfth century,2 at the monastery founded by the saint at Elnone-en-Pevele, today St.-Amand-les-Eaux.3 The manuscript is the earliest of three illustrated copies of the life of the saint, all preserved in the public library of Valenciennes. Only the first and third copies, MSS 502 and 500, contain a narrative cycle of illustrations, the later one based on MS 502.4


STARTING next year, the voices of the various groups responsible for recommendations about the use of childhood vaccines will sing in unison. Since 1965, efforts have been made to try to ensure compatibility in the recommendations dealing with vaccine use made by public health and physicians' groups, but differences still arose. A number of groups routinely make such recommendations. They include the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention (CDC), the American Academy of Pediatrics (AAP), and the American Academy of Family Physicians (AAFP). Late last year, these groups gave a mandate to the CDC to develop a common immunization schedule for the administration of childhood vaccines. The mandate was backed by the CDC's working group on immunization, and an ad hoc group was created to draft such as a schedule. 'An Unambiguous Message' "There are many reasons for providing an unambiguous message


Objective: To establish HPLC method for the determination of atractylenolide Ⅰ in Guipi pills.Methods: Atractylenolide Ⅰ in Guipi pills was determined by HPLC,using kromasil Cl8 column,methanol-water(55:45) as mobile phase,the detection wavelength was 220 nm.The flow rate was 1.0 ml·min-1.RESULTS: The linear range of atractylenolide Ⅰ was 2.08~31.2 μg·ml-1,coefficient correlation r was 0.9994,the average recovery of atractylenolide Ⅰ was 95.43% with RSD% of 1.51%.Conclusion: The method is simple,rapid,accurate and repreatable.It can be used for determination of atractylenolide Ⅰ in Guipi pills.


One of the most significant tools for expressing physical phenomena in the world around us is to express problems using differential equations with partial derivatives. The result of these considerations has been the invention and application of various analytical and numerical methods in solving this category of equations. In this work, we make use of a newly-developed technique called the generated exponential rational function method to compute the exact solution of the Davey-Stewartson equation. According to all the conducted research studies so far, results similar to those found in the present paper have not been published. The results attest to the efficiency of the proposed method. The method used in this paper has the ability to be implemented in other cases in solving equations with relative derivatives.


The paper introduces the GIS development,and aiming at special geography environment in northwest region,put forward the method of object-oriented,fusion database technique,multi-media technique,the network technique,set up c/s geography information system,manages and analyze the geography information of important aim in northwest region.


Sir, Mucocutaneous side effects associated with bleomycin are stomatitis, ulcers, scaly erythematous and bullous lesions, sclerosis, nail changes, digital gangrene and pigmentary alterations. Hyperpigmentation occurring mainly on the pressure areas of the skin as well as in areas of scratch marks is seen in approximately 30% of patients. Flagellate hyperpigmentation is very characteristic of bleomycin.


The present invention relates to a method for synthesis of optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids from an asymmetric α-hydroxy ester. The chiron approach of the present invention utilizes a non-nucleophilic lithium amide base under kinetically controlled Clasien conditions to produce a 4-substituted-2-pheylmethoxy precursor to the 4-substituted-2-hydroxy tetronic acid. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. The invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.


The existence of global weak solution for a class of generalized Ginzburg-Landau equations with an inhomogeneous boundary condition was studied. Some integral indentities of smooth solution of inhomogeneous initial boundary value problem of Ginzburg-Landau equations were deduced, by which a priori estimates of the square norm on boundary of normal derivative and the square norm of partial derivatives were obtained. Then the existence of global weak solution for an inhomogeneous initial boundary value problem of Ginzburg-Landau equations was proved by the method of approximation technique and a priori estimates and making limit.


Examination of the base-catalysed condensation of ethyl chloroacetate with indan-1-one has established that potassium t-butoxide is preferable to either sodamide or sodium ethoxide as condensing agent. Hydrolysis of the ester formed is shown to yield not the expected glycidic acid (indan-1-spiro-2'-oxiran-3'-carboxylic acid), but the isomeric alpha-hydroxyindenyl-1(3)-acetic acid together with a small proportion of indenylidene-1-acetic acid. The structure assigned to the hydroxy acid is based upon spectroscopic data, the chemical properties of the ester and of the acid, and upon its identity with the acid formed by Claisen hydrolysis of authentic ethyl alpha-hydroxy- indenyl-1(3)-acetate. Decarboxylation of the acid, which occurs at the melting-point, is accompanied by an unusual isomerisation to yield 1-formylindane, the expected decarboxylation product of the glyoidic acid. Although it is found that some indenylidene-acetic acid is formed as a by-product in the Claisen hydrolysis, this does not rule out other precursors of the acid being formed in the condensation reaction e.g. by reaction involving the active methylene group of the enolised ketone. This aspect was investigated by the use of substituted indan-l-ones which would yield different products by the alternative paths. The product from 5-methoxyindan-1-one is shown to be 5-methoxyindenylidene-l-acetic acid, proving that condensation with the chloroester occurs with the carbonyl group of the ketone, a result confirmed by the corresponding reaction with 6-methoxyindan-1-one, With 2,2-dimethylindan-1-one, a corresponding dienoic acid cannot be formed. The condensation with ethyl chloroacetate occurs less readily than with indan-1-one to give an ester (contaminated with the alpha-oxoester), which on hydrolysis gives a very low yield of a product best formulated as the glycidic acid. The condensation is accompanied by the formation of ethyl ethoxyacetate derived from ethyl chloroacetate by interaction with the condensing agent. Phenyl 2-phenylethyl ketone, the open-chain analogue of indan-1-one, yields the normal glycidic ester in this reaction; no rearrangement products were isolated. Decarboxylation of the acid (to yield 2,4-diphenylbutan-1-al) occurs more readily than with the aforementioned hydroxy-acid.


This article introduces several kind of newest broadband way of access, and unifies Tiefa Coal Industry characteristic elaborated suits the mining district use broadband way of access and the mining district broadband application situation.


The main purpose of this paper is to investigate diagonal lift of tensor fields of type (1,1) from manifold M to its semi-cotangent bundle t*M. In this context cross-sections in semi-cotangent (pull-back) bundle t*M of cotangent bundle T*M by using projection (submersion) of the tangent bundle TM can be also defined.


CPU or SoC in the embedded system is considered the ''trusted root,'' and all the other components are unauthentic. Secure engine (SE) is a component in CPU or SoC, whose duty is to provide data encryption and authentication when they go through SE. A novel and efficient SE is proposed in this abstract. It adopts OTP encryption and GCM as working mode when processing cryptographic issues. Each block is assigned a counter which is stored in memory. When the block is replaced out from the cache, its counter is added 1. For example, the ith block is indicated as blocki and its counter counteri. Blocki is divided into for sub-blocks. Using this counter, each block generates a unique seed as address||counter||EIV. By this seed, SE computes pad as Ekey(address||counter||EIV), where ''key'' indicates the system key which is a system-wide secret. Then, GCM mode will simultaneously output the encrypted block and its MAC. These methods will help to vault the system performance greatly, according to our simulation. Besides the basic architecture, we propose a counter cache structure to SE and an accelerated MAC verification to enhance the system efficiency. Counter cache adopts the locality feature of memory to expedite counter reading. The accelerated MAC helps each block to store its corresponding MAC value in a parallel MAC memory which hides MAC read latency by overlapping by main memory latency.


During research on the indirect determination of moisture in coal, the authors examine the errors possible when using a desiccator, and study the relative values of various desiccants. They conclude that an ordinary desiccator, regardless of the efficiency of the desiccant it contains, is of little use in preventing absorption of moisture by the dried coal, and that it can be abandoned provided that the moisture dishes bear well-fitting covers, and that the time between drying and weighing is reduced to a minimum.


Here we report a case of infrarenal abdominal aortic occlusion secondary to Stanford type A acute aortic dissection, which was successfully treated with percutaneous fenestration and aortic stent placement. Adequate flow to the occluded infrarenal abdominal aorta was not restored by means of percutaneous fenestration alone, so an additional procedure, aortic stent placement, was required to buttress the true lumen and fenestra. We discuss ischemic complications of aortic dissection and related percutaneous intervention and review the literature.


In general the objective of E-Maintenance is to organize, structure and link the Information and Communication Technologies (ICT) to develop a maintenance support system that is effective and efficient during the whole life cycle of the product. Among the many challenges of E-Maintenance, human centered solutions that can better assist technicians and engineers are emerging, using ICT resources integrated with visualization technologies, such as Augmented Reality (AR). Supported by a human centered infrastructure, AR can bring knowledge to the real physical world, to assist the technician perform his/her work without needing to interrupt to consult manuals or electronic systems for information, real time data and safety issues. This work reviews solutions to create a human centered E-Maintenance and discusses the steps to implement this vision.


This work details the development of a prosperous Jewish community in the Sudan. The author chronicles the history of the original group of eight families, providing family histories and tracing the families to their new homelands as well as providing an autobigraphical account.


The Late Antique roman-byzantine society is a constantly changing world. A new political and military background also calls for economic, social and cultural changes. In such an instable world the abuse was inevitable. The existing historical research focused mainly on the abuses of public authorities and even on imperial abuses. This paper is a research on the abuse of private owners against the public property. Using archaeological and historical evidences there had been identified two kinds of abuses: invasion of the public property and the use of spolia. This paper is divided in two parts, analysing those two kinds of abuses. The main primary sources which the author used in this paper were the laws combined in the Theodosian Code and also in the Iustinian Code which showed us the perspective of state regarding the abuse of private owners who affected the integrity of the public domain. Studying them we came to the conclusion that the state failed to stop those abuses and ended up by accepting these behaviours. This new kind of attitude of individuals toward urban landscape may show us a new perspective of how the "city" is understood. The consequence of this new behaviour is dramatic for the image of urban landscape in Late Antiquity.


Total data on heavy metal accumulation (Ti, Fe, Mn, Sr, Rb, V, Cr, Co, Ni, Cu, Zn, Pb) in leaves of the common for natural forests of the Samara Region nut, fruit and berry plants such as Cerasus fruticosa Pall., Corylus avellana L., Malus sylvestris (L.) Mill., Padus avium Mill., Viburnum opulus L. were given in the paper.


Four types of materials, type I collagen coat (Coat), acid‐soluble type I collagen gel (Hardgel), pepsin‐treated acid‐soluble type I collagen gel (Softgel), and an extract of extracellular matrix of the murine Engelbreth‐Holm‐Swarm sarcoma (Matrigel), were used as matrices to culture rat hepatic parenchymal cells, and their morphological changes and adhesion were compared to the matrices by electron microscopic observations. Hepatic parenchymal cells cultured on Coat and Hardgel were extended and flattened, whereas cells cultured on Softgel and Matrigel assembled and formed aggregates. Such aggregates consisted of several hepatic parenchymal cells, with a recognizable bile duct‐like alveolus on the inside. Morphologically, the aggregates were more spherical on Matrigel and oval shaped on Softgel. Microvilli of the cell surface were parallel to the matrix on Matrigel, but invaded into the gel on Softgel. Subsequently, investigation into how these morphological features affected the liver‐specific functions, including secretion of albumin and induction of P450 by 3‐methylcholanthrene, demonstrated that a high level of liver function was maintained in a long‐term culture in hepatic parenchymal cells on Softgel. These results suggest that hepatic parenchymal cell interactions were stronger with Softgel than with Matrigel, and that Softgel appears to closely mimic the in vivo environment.


Experiences in social innovation point to a collaborative work, in which several types of players connect in a network to seek solutions to the problems inherent in the less favored population. In this sense, the aim of this paper is to identify the constituent elements of collaboration networks for social innovation in the context of social incubators. This study used a qualitative, descriptive research approach and case study method. Data were collected through document analysis and semi-structured interviews. Based on the thematic analysis of the primary data, it was concluded that the constituent elements of collaboration networks for social innovation in social incubators are: partnerships (networks of players and different types of partnerships); collaboration (mutual help, commitment and trust); self-management (shared leadership, joint decision-making and shared processes); empowerment (recognition and construction of identity); resources (financial, material and human); learning (training, lectures and sharing of experiences); and sustainability (economic, social and environmental


: This paper explores the trajectory tracking strategy of a six-axis manipulator based on the kinematics model predictive control. Firstly, the kinematics of the manipulator was analyzed, and modeled mathematically. Next, the pose errors of the end effector were determined against the error parameters involving joints and rods. After that, the pose error model of the end effector was adopted to quantify how much the errors of different parameters affect the location of the manipulator. Finally, the geometric errors of manipulator trajectory were identified by the least squares (LS) method. Experimental results show the effectiveness of our model. The research results provide a reference for the theoretical analysis and application of manipulator trajectory tracking strategy.


The college television and journalism educational conditions in Chongqing are analyzed.An abundant affirmation is given to the achievements gained,and the problems are pointed out and several reform proposals are given.


Recently the number of university has been increased rapidly and the number of student who want to enter the university has been decreased. So every university try to provide resting place and student lounge for their survival. this project was designed to provide the student more convenient and comfortable resting place. this lounge is placed in the main building which is the main space and the most useful place in the university. So the design concept is to provide the space which has young and bright and also useful so the student can feel high-tech interior design.


For believers in nuclear arms control the last few months have had a nightmarish quality—as though the dykes were suddenly collapsing all around and the deluge engulfing us from all directions:•the nato decision to introduce intermediate range nuclear missiles (the Pershing II) and ground-launched cruise missiles (glcm) to match "modernization" of the Soviet irbm force with the mobile SS-20;•the collapse of salt II;•the imminent deployment of the U.S. counterforce-capable mx missile in a provocative multiple-shelter mode, with a new limited nuclear doctrine to match;•the upgrading by the Soviets of their first-strike threatening SS-18 and -19 rocket forces; and•the general deterioration of Soviet-American relations.In view of all these developments, the Bulletin will, in the next months, try to reassess the status of the U.S.-Soviet nuclear arms race, and its implications for the future of this threatening confrontation. We shall try to elucidate the implications of this arms race on the security of all t...


The butyrylcholinesterase (BChE) is a serum esterase encoded by the BCHE gene and synthesized in the liver. Its physiological function has not been fully clarified, however, evidences correlate it to various aspects such as lipid metabolism and obesity. The BChE can be present in plasma as a monomer, dimer, trimer, tetramer and / or associated with other substances such as albumin. The relative intensities of the molecular forms of BChE (G4, G2, G1 and G1-alb), obtained by polyacrylamide gel electrophoresis and by its quantification in the KODAK 1D Image Analysis Software program, were the grounding of study in this work. The sample consisted of 68 obese adolescents who were subjected to 12 weeks of physical exercise, and had their blood samples taken before and after the end of the 12 weeks. Although there is no significant difference between the frequency of absence of bands presented in the samples before and after the exercises, an increasing trend of absence can be observed in the samples after exercises. This result is consistent with that obtained by Boberg (2008). Regarding the joint behavior of the bands, a negative correlation was obtained between G4 and the other bands (G2, G1 and G1-alb) either with the samples before and post exercise. This correlation behavior obtained is probably due to the fact that the molecular forms G1, G2 and G4 are partially interconvertible, or rather, G1 and G2 forms are precursors and / or degradation products of G4.


Objective To study the protective effects of nitric oxide (NO) on the reperfusion injury following pancreaticoduodenal transplantation in rats.Methods The (homologous) male Wistar rat model of heterotopic total pancreaticoduodenal transplantation was used.The L-Arg-treated rats received the intravenous injection of L-Arg 5 mins before and after operation at a dose of 200 mg/kg while the L-NAME-treated rats at a dose of 10 mg/kg.The content of NO in the pancrease graft was measured.Serum concentration of cytokine-induced neutrophil chemoattractant (CINC) was determined by enzyme-linked immunosorbant assay,the expression of CINC mRNA detected by Northern blot assay in the pancrease graft,and the activity of myeloperoxidase (MPO) was measured.Histological observation was performed.Results The content of NO in the L-Arg group (0.37±0.09) μmol/L was higher than in the control group (0.28±0.07) μmol/L,while that in the L-NAME group (0.19±0.10) μmol/L was lower than in the control group ( P 0.05).The peak of serum CINC concentration occurred 3 h after reperfusion with the difference among the groups being significiant.The expression peak of CINC mRNA in the pancrease graft occurred 3 h after reperfusion,and the expression level in the L-Arg group was lower in the control group,while that in the L-NAME group was higher than in the control group ( P 0.05).The activity of MPO in the L-Arg group was obviously decreasd as compared with that in the other groups.The pancrease inflammation was ameliorated when L-Arg was administrated,while the pancrease damage was aggravated when L-NAME was administrated.Conclusion L-Arg can increase the content of NO,while LNAME can reduce it.NO can inhibit the elevation of CINC,the CINC mRNA expression and early neutrophil accumulation in the pancreas.NO has protective effects on the ischemia/reperfusion injury of pancreaticoduodenal transplantation.


Seventeen cases of compressive optic neuropathy caused by orbital masses were examined with a 30-degree threshold program of automated perimetry. The orbital pathologies were represented by five cases of Graves' orbitopathy, three optic nerve sheath meningiomas, two hemangiopericytomas, two diffuse pseudotumors, one perineuritis, one case of orbital varices with hemorrhage, one lymphoma, one ethmoidal carcinoma and one suspected angioma. Visual field alterations varied from arcuate, inferior altitudinal and cecocentral scotomas, to temporal hemianopsy, nasal step and diffuse losses. In three cases (one Graves', one acute diffuse pseu-dotumor and one perineuritis), steroid administration was followed by partial or full perimetric recovery; in one case (orbital varices with hemorrhage) the full recovery was spontaneous, while in one case of benign hemangiopericytoma, the surgical removal of the tumor caused a significant improvement of the visual field.In the authors' series, perimetric pattern reflects the...


Men with advanced prostate cancer (PC) are treated by androgen deprivation therapy but the disease recurs as incurable castration-resistant prostate cancer (CRPC), requiring new treatment options. We previously demonstrated that the G protein-coupled receptor (GPCR) arginine vasopressin receptor type1A (AVPR1A) is expressed in CRPC and promotes castration resistant growth in vitro and in vivo. AVPR1A is part of a family of GPCR's including arginine vasopressin receptor type 2 (AVPR2). Interrogation of PC patient sample data revealed that co-expression of AVPR1A and AVPR2 is highly correlated with disease progression. Stimulation of AVPR2 with a selective agonist desmopressin promoted CRPC cell proliferation through cAMP/protein kinase A signaling, consistent with AVPR2 coupling to the G alpha s subunit. By contrast, blocking AVPR2 with a selective FDA-approved antagonist, Tolvaptan, reduced cell growth. In CRPC xenografts, antagonizing AVPR2, AVPR1A or both significantly reduced CRPC tumor growth as well as decreased on-target markers of tumor burden. Combinatorial use of AVPR1A and AVPR2 antagonists promoted apoptosis synergistically in CRPC cells. Furthermore, we found that castration-resistant cells produced AVP, the endogenous ligand for arginine vasopressin receptors, and knock-out of AVP in CRPC cells significantly reduced proliferation suggesting possible AVP autocrine signaling. These data indicate that the AVP/arginine vasopressin receptor signaling axis represents a promising and clinically actionable target for CRPC. Implications: The arginine vasopressin signaling axis in castration resistant prostate cancer provides a therapeutic window that is targetable through repurposing safe and effective arginine vasopressin receptor type 1A and 2 antagonists.


Objective To study the role of inositol requiring enzyme 1(IRE1)-mediated endoplasmic reticulum stress on hepatocyte apoptosis of experimental fulminant hepatic failure(FHF). Methods Thirty male depuratory Wistar


Acknowledgments A note on texts and references Introduction 1. 'Of Man': the foundation of Hobbe's political argument 2. What is the cause of conflict in the state of nature? 3. The shortsightedness account of conflict and the laws of nature 4. The argument of absolute sovereignty 5. Authorizing the sovereign 6. Hobbe's social contract 7. The failure of Hobbe's social contract argument 8. Can Hobbe's argument be salvaged? 9. How the traditional social contract argument works Bibliography Index.


Web log mining is a branch of web usage mining and has special theory and practice singnficance as an important part of web mining in database research fields.In this paper,the concept of web log mining was introduced and the process of web log mining which includes date collecting,data preprocessing,pattern recognition and application was reported.in view of its wide application,Web log mining can optimize websites.


Table-to-Text generation is to express the information in the table in words. Considering the simplicity and logic of the statement, the task of logical Table-to-Text generation is derived. Logical Table-to-Text generation is to generate logically faithful and smooth text based on tables. However, there are few studies on this task at present, and the effect of related generative models is not ideal, which makes this task still very challenging. In this paper, we propose a three-stage generative model that conforms to the human thinking of generating logical texts. On the basis of generating surface fact texts from tables, coarse templates are generated first, and then logical texts are generated. At the same time, in order to enhance the rationality of generating texts of different logical types from the same table input, we propose to take the logical type of the reference text as a known premise and input it together with the table and table title to generate texts with higher similarity. Experiments on the LogicNLG dataset show that both ideas have their effectiveness, and the model outperforms the baseline model overall. Combining the two ideas for experiments, the overall effect of the model is better, especially in terms of text similarity.


A long fiber reinforced pellet containing an inorganic material is provided to ensure excellent mechanical property and to show excellent flexural modulus without the degradation of tensile strength and impact strength. A long fiber reinforced pellet containing an inorganic material comprises a thermosetting polymer resin 20-80 weight% having the melt index of 0.1-80 g/10min at a temperature of 230 °C and under the load of 2.16 kg; a fiber reinforcing material 10-40 weight% having the length of 5-50 mm; and an inorganic material 10-40 weight% having the average particle size of 1-10 micrometer. The inorganic material comprises talc, calcium carbonate and barium sulfate, wherein the weight ratio of talc : calcium carbonate : barium sulfate is 1 : 0.5~2 : 0.5~2. The fiber reinforcing material has the average diameter of 0.3-50 micrometer and has the same length as the inorganic material-containing long fiber reinforced pellet.


Dose equalization by the GHOST technique fails to provide homogeneous contrast when the two‐Gaussian model does not adequately portray the beam‐energy dose distribution. This leads to an undesirable pattern dependence to the contrast obtained. The degree to which this breakdown occurs is shown in computer simulation. The most severe breakdown occurs in enclosed (annular) structures where the effect of ''higher order'' Gaussian deposition peaks are concentrated. Unanticipated background fluctuations of about 10% of the nominal exposure dose are obtained. As a result of this study, test structures are proposed which can extend the utility of dose equalization.


It is necessary to detect and monitor the distribution of mircophytobenthos (or algal mat) in tidal flats. KOMPSAT-2 will provide multi-spectral images with a spatial resolution of 4 m comparable with IKONOS. Using IKONOS and Landsat data, algal mat detection was tested in the Saemangeum area. Micro-benthic diatoms are abundant and a major primary product in the tidal flats. Fine grained upper tidal flats is considered to be the best conditions for microphythobenthos. A different type of microphytobenthos was found in coarse grained lower tidal flats. The newly reported microphytobenthos are algae and they began to exist after dike construction. A linear spectral unmixing (LSU) method was applied to the test data. The end-members were obtained by both spectral libraries built from field surveys and a remotely sensed image itself. End-members from spectral library were slightly more effective than those from image itself. A high resolution multi-spectral sensor in KOMPSAT-2 will provide useful data for long-term monitoring of microphytobenthos in tidal flats.