Within the diagrammatic real time approach \cite{K\"onig96, Schoeller97}, the current across a quantum dot which is tunnel coupled to two leads at different chemical potentials is calculated by the use of two objects referred to as kernels. The stationary reduced density matrix of the quantum dot is determined by the use of the density matrix kernel, while the current kernel is used in a second step to determine the stationary current across the dot. If the tunneling Hamiltonian is multiplied by a coupling parameter ``w``, then everything, including the kernels, the stationary density matrix as well as the stationary current, can be viewed as a function of w. In the time space, and at every single and fixed time t, the kernels have the clear structure of a convergent power series in w. Refer to the coefficients of these power series as the orders of the kernels. It is intuitive to truncate the kernels at some finite order and to perform remaining calculations by the use of the corresponding approximate kernels. However, the quantities which actually appear in the calculations are not the kernels as a function of time but rather their Laplace transforms, and here only in the limit \lambda \to 0. The statement that even in this limit the structure of a convergent power series in the coupling parameter is still conserved is shown in the text. The statement that the stationary density matrix and current are still analytic in the coupling parameter is shown, assuming the quantum dot is the single impurity Anderson model (SIAM). Finally, results for the kernels up to sixth order, neglecting the doubly occupied state and assuming equal energies E_\uparrow= E_\downarrow, are presented and discussed. In case the degenerate level lies below the Fermi level, a zero bias resonance, getting more and more pronounced with decreasing temperature, is expected.


Supply Chain Event Management (SCEM) is an approach aiming to fill the gap between Supply Chain Planning and Supply Chain Execution. The goal of SCEM applications is to monitor the states of supply chains by observing specific events and exceptions in real-time and alerting managers if problems occur. This paper presents an architecture for a mobile SCEM system based on software agents, Auto-ID technologies, and mobile computing. It introduces the main layers and components of this architecture. A special focus is placed on web services, mobile user interfaces, and integration of a multi-agent platform as innovative solutions to improve SCEM.


A composite additive for flue gas desulfurization according to a limestone method is composed of the following materials by mass: 85 to 90 percent of nylon acid extracted residue, 1 to 3 percent of salicylic acid, 1 to 3 percent of humic acid, 1 to 5 percent of manganese chloride, and 1 to 5 percent of dimethyl silicone antifoaming agent which are mixed with each other, wherein nylon acid extracted residue is the residue of nylon acid extracted with a large part of glutaric acid. The composite additive has the beneficial effects that the defects of deeper color and unqualified desulfuration drainage chromaticity caused when a nylon acid-type additive is used for flue gas desulfurization are overcome; the pH value buffer zone is wider; sulfur dioxide gas can be dissolved in limestone paste faster; the dissolution of limestone calcium carbonate can be accelerated; the desulfuration efficiency is improved; the cost is greatly reduced; the oxidation efficiency of calcium sulfite is improved; the poisoning problem of limestone paste liquid is solved; foam of a desulfurization tower is eliminated; and the efficient steady operation of the desulfurization tower can be guaranteed.


Synopsis Experiments on sealed specimens of hardened cement paste, initially conditioned to different moisture contents, have shown that measured reductions in creep with age at loading were not due solely to hydration changes. A 50% reduction in creep with age at load was measured on non-hydrating specimens. There was a correlation between elastic and creep strains of specimens with a wide range of porosities and moisture contents which was age-dependent. The experimental results for hardened cement paste compare well with published data for concrete.


Experiments on electrical properties of carbon nanotube (CNT) composites have shown that addition of CNTs may greatly enhance the electrical conductivity of the matrix. It has been a key but unresolved issue for years how to develop an analytical model of effective electrical conductivity of CNT composites that takes account of not only the CNT concentration and percolation, but also CNT conductivity anisotropy, aspect ratio, and nonstraightness. Such a model is established in this letter. The model predictions agree well with the measured data available in literatures and are also extended to account the effect of the orientation distribution of CNTs.


This paper discusses an extension of the fast multipole method to electromagnetic scattering from doubly periodic, multilayer wafer topography. The novelty of our approach lies in the use of a pseudo-periodic translation operator which can be computed efficiently using fast Fourier transform. Results obtained using the rigorous boundary conditions for dielectric surfaces are compared with those obtained using the approximate impedance boundary condition. The latter is shown to give good results for the type of topography usually encountered in lithography simulation. Results of reflective-notching simulation using the IBC method are presented.


The effects of ultra-high pressure (UHP) on 25 starches were characterized via microscopy and DSC. Furthermore, the swelling behaviour, digestibility, paste viscosity and gel formation was determined. With few exceptions B-starches were shown to be more pressure resistant than A- and C-type starches. The pressure range in which the gelatinization occurs is typical for the corresponding starch. Only some starches (e.g. waxy corn starch) show the extensive swelling and almost complete desintegration of the granules, which usually is observed after a heat gelatinization. Typical for a UHP-gelatinization is, that most starches show very little swelling and maintain their granular character. These starches develope very little viscosity at normal paste concentrations and form pastes of smooth texture, resp. rigid gels at concentrations above 15%.

Due to the limited swelling without any resp. very little solubilization of the amylose obviously the retrogradation occurs within the granules, which probably is a further reason for the quite different paste and gel properties of UHP-gelatinized starches in comparison to heat gelatinized ones.


Purpose We examine how supervisor stress is associated with employee-rated abusive supervision. In addition, we test the premise that higher levels of physical exercise by supervisors can buffer the negative effects of stress on their relationship with their subordinates. Design/Methodology/Approach A matched sample of 98 employed individuals and their direct supervisors was used to test our hypotheses. Findings Results suggest that increased levels of super-visor-reported stress are related to the increased experience of employee-rated abusive supervision. We also find that the relationship between supervisor stress and abusive behavior can be diminished when supervisors engage in moderate levels of physical exercise. Implications While the current economic conditions and a host of other trying workplace factors mean that supervisors are likely to experience workplace stress, we found evidence that they do not necessarily have to transfer these frustrations onto those they supervise. Our study supports a link between supervisor stress and employee perceptions of abusive supervision, but this is a link that can be loosened if supervisors engage in moderate levels of physical exercise. Originality/Value The results of this study add to the modest number of antecedents to abusive supervision that have been discovered in existing research. In addition, this is the first study to examine how exercise can buffer the relationship between supervisor stress and employee perceptions of abusive supervision.


Keywords: Systems integration, XML, automation design Abstract: This paper presents results obtained in systems integration in order to improve information management during an automation project. The paper is based on research made in Novel Information Integration Technologies and Models (NIITM) pr oject by the Institute of Automation and Control (ACI) at Tampere University of Technology (TUT). Due to the number of parties participating in the design phase of an automation project, various design, engineering and operational systems are needed. At the moment, the means to transfer information from one system to another system, so that it can be further processed or reused, are not efficient. An integration approach in which XML technologies are utilized for implementing systems integration is introduced. Data content of systems are defined by XML Schema instances. XML messages containing automation design informatio n are transformed using transformation stylesheets employing a generic standard vocabulary. Loosely coupled, platform independent, data content-oriented integration is enabled by XML technologies. A case study that proceeds according to the approach is also described. It is found that XML technologies seem to be a part of the right solution. However, some issues related to schema design and transformations are problematic. If complex systems are integrated, XML technologies alone are not sufficient.


Aims:  Transmission routes of noroviruses, leading aetiological agents of acute gastroenteritis, are rarely verified when outbreaks occur. Because the destination of norovirus particles being firmly captured by micro‐organisms could be totally different from that of those particles moving freely, micro‐organisms with natural affinity ligands such as virus‐binding proteins would affect the fate of viruses in environment, if such microbial affinity ligands exist. The aim of this study is to identify norovirus‐binding proteins (NoVBPs) that are presumably working as natural ligands for norovirus particles in water environments.


The degradation of the two pesticides rotenone and paraquat by anodic oxidation using a boron doped diamond (BDD) anode and a carbon felt cathode were studied. The effects of various operating parameters (dissolved oxygen, nature of electrolyte and applied current) on the degradation rate and the mineralization efficiency have been investigated and the key-role of dissolved oxygen elucidated. A very high mineralization rates were obtained for both pesticides (yielding 98% and 97% COD and TOC decay, respectively). The decay kinetics follow a pseudo-first order reactions. Reversed-phase chromatographic analysis revealed the appearance of various aromatic intermediates. Among them, hydroquinone and 12aβ-hydroxyrotenone which were identified by LC-MS-MS as oxidative degradation by-products of rotenone. The mineralization effectiness was exhibited following the concentration profiles of generated short-chain aliphatic carboxylic acids (such as formic, oxalic, acetic and succinic acids) using ionexclusion chromatography. The mineralization process of paraquat leads to a complete release of nitrate ions and to the total disappearance of chloride ions at the end of treatment.


ObjectiveTo assess the need for testing a third sputum sample for the diagnosis of active pulmonary tuberculosis (PTB). MethodReview of the records of all sputum culture proven cases of active PTB in the state of Qatar diagnosed from 2002 to 2008. ResultsDuring the 7-year study period, 687 cases of culture proven PTB were diagnosed in Qatar. Five hundred one cases had at least one positive sputum smear for acid-fast bacillus (73%). Among these, 363 cases had 3 consecutive sputum samples tested. There was no statistically significant difference in sensitivity between the first, second, and third sputum samples in detecting the acid-fast bacilli on direct fluorescent microscopy (81.3%, 83.5%, and 82.3%, respectively). The sensitivity of the first sample in establishing diagnosis was 81.3%, increasing to 96.2% if 2 sputum specimens were tested (14.9% incremental benefit). Testing a third specimen increased the sensitivity to 100% (3.8% incremental benefit). ConclusionBased on our results and to deal with the increasing number of cases of suspected PTB seen in the State of Qatar in the last few years as well as to minimize the increasing demand for isolation rooms and the burden on our laboratory, we recommend that testing only 2 sputum specimens for acid-fast bacilli instead of 3 is probably safe and is adequate for the diagnosis of PTB.


Objective: To determine the resistance rates of clinical isolates from patients of 13 hospitals located in different areas of China. Methods: A total of 2 554 clinical isolates collected from 13 hospitals. Bacterial susceptibility testing was done by agar dilution method. Results were assessed according to NCCLS (2001). Results:Of 2 554 strains, 958 (37. 5%) were Gram-positive cocci and 1 596(62. 5%) were Gram-negative bacilli. Moxifloxacin and gatifloxacin were more active against Gram-positive cocci than the other fluoroquinolones tested (P0. 05). Moxifloxacin and gatifloxacin also had good antibacterial activities against Gram-negative bacilli. Among all the fluoroquinolones tested, levofloxacin had the lowest resistance rates on Acineto-bacter spp. and Pseudomonas aeruginosa. Conclusions: Moxifloxacin and gatifloxacin have higher antibacterial activities against Gram-positive cocci than the other fluoroquinolones, while reserving good antibacterial activities against Gram-negative bacilli. Rational use of antimicrobials is most important for the containment of bacterial resistance.


Stress corrosion cracking (SCC) susceptibility of some h.c.p. metals: titanium, zirconium and one of its alloys, Zircaloy-4, was investigated in iodine-methanol solutions. Slow strain rate tests were carried out until the rupture of the specimens, in some cases interrupted strain rate tests were conducted. SCC was observed in all the systems studied, but preceding crack propagation, intergranular attack was found in all cases, and this intergranular attack was due to anodic dissolution of the grain boundaries. The rate controlling step is the diffusion of iodine to the tip of the advanced crack. It was also demonstrated, that it is necessary to locally disrupt the passive film to induce SCC in these materials and this is done by the chemical effect of the iodine molecules on both, titanium and zirconium oxide film. Once the intergranular attack reaches a certain value, a transition to a transgranular cracking mode occurs. This last step was identified as the true SCC process. The surface-mobility SCC mechanism was applied to explain the results obtained.


Increasing and expanding oil and gas processing was accompanied by high demand on water. As a crucial element for both life and agriculture, water sources have to be kept unpolluted and preserved from the pollutant and high consumption from such industries. Thus, came to exist water re-use. Before water re-use can be optimized within a natural gas processing facility, all process water streams and utility water streams must be considered to operate in an integrated fashion that minimizes the water intake and discharge. and water treatment. The cooling system in the North Gas Company is the most demanding unit in terms of water requirement. In this research a water treatment unit is proposed to eliminate and reduce water and pollutants discharged to the Zab channel and well as minimize the water intake to the North Gas Company. For this purpose, an RO units are designed to treat the effluents and the makeup water using IMSDesign 2017 provided by Hydranautics. The optimum membrane type was found to be CPA6 MAX; a brackish water high rejection membrane that has a production rate of 8800 gallon/day and 440 ft2 area.


Abstract This article explores the interface between religion and international humanitarian law (IHL), and the degree to which they might complement and reinforce each other. It examines some of the challenges inherent in regulating armed conflict and the understandable limitations of IHL in this respect, and argues that re-engagement with IHL's religious roots can help to alleviate them. Engagement with religious circles mobilizes the vast resources of religions to increase knowledge of IHL and corresponding religious norms, thereby enhancing their legitimacy across religious and cultural divides. This is most effective when comparative study of IHL and religious teachings stimulates mutual learning and debate, in which both correspondences and differences are embraced. In the absence of a strong legal enforcement regime, religions can reinforce military ethics by tapping deeply into the identities, motivations and moral values of many belligerents, and possess powerful means to socialize the rules of war and improve voluntary compliance. Introspective religious practices encourage the moral self-reflection that is most effective at internalizing norms in this respect, as well as providing belligerents with the spiritual and psychological support needed to bolster their resilience and enable them to perform with precision and restraint.


Abstract Currently, there are over 200 officially registered sulfur springs in Slovakia, most of which are cold hydrogen sulfide springs with a characteristic strong odor of rotten eggs. Their typical inhabitants are filamentous sulfur-oxidizing bacteria. The aim of this study was to identify the major bacterial populations inhabiting sulfur springs in Slovakia using a combination of non-cultivation and cultivation approaches. Non-cultivation analyses revealed high variability of sulfur-oxidizing bacteria in Slovak springs. Sulfur mats were usually dominated by chemolithotrophic sulfur-oxidizers from the phylum Proteobacteria (more than 87%), followed by photoautotrophic sulfur-oxidizers of the phylum Chlorobi. The group of nonsulfur-oxidizers was composed of typical freshwater species and bacteria with genetic potential for sulfur oxidation. The low similarity in the 16S rRNA gene sequence of the sequenced DGGE bands indicates that about half of the sulfur-oxidizing bacteria identified represent new species/genera of sulfur-oxidizing bacteria. In attempts to cultivate potential new species of sulfur-oxidizing bacteria, a very low overlap was observed between non-cultivation and cultivation analyses, and a new species of the Thiofaba genus was cultivated. Our results expand knowledge on the diversity of sulfur bacteria in cold sulfur springs in Slovakia and indicate that the diversity of sulfur-oxidizing bacteria is significantly underestimated and that sulfur springs could be inhabited by unique bacterial populations.


The principle of two type of passive vibration reduction of auxiliary magnetic bearing is discussed. And the principle is tested using an experimental rotor system adopting auxiliary magnetic bearing. The results show that active magnetic actuator with constant voltage provides not only stiffness but also damping which varies with the frequency of the motion of the rotor. And the additional stiffness also consists of two items, namely the static stiffness and the dynamic stiffness in which the former one is negative and the latter one is positive. While active magnetic actuator with constant current just provides the static stiffness.


The application of rapeseed oil (RO) blends with diesel fuel and/or alcohols and/or ethers is known to significantly affect the combustion process. Aiming to further investigate the effects of rapeseed oil in a blend with diethyl ether (DEE) on this process, the coefficient of variation of the mean indicated pressure (COVMIP) of a 2.5l direct injection diesel engine was calculated. The analysis of the experimental results revealed the repeatability of the combustion process variability of diesel fuel (DF), rapeseed oil (RO), and DEE/RO blends containing up to 20% DEE. In these cases, the COVMIP does not exceed 4%. Additionally, it became obvious that for a higher content of DEE in blend with RO, the cyclic repeatability of the mean indicated pressure (MIP) was reduced. Thus, the values of COVMIP for fuels containing 30 and 40% of DEE by vol. in blend with RO were even three times higher than the values obtained for the reference fuel i.e., DF. The results indicate that the increased content of DEE in the mixture with RO is disadvantageous as it leads to excessive unevenness of the engine operation compared to its fueling with DF. The observed deterioration of the combustion process is caused by the vapor locks, which are formed due to the evaporation of volatile DEE in the fuel line, leading to the interrupted operation of the fuel injector.


Nikolai Moldovyan and Alexander Moldovyan, holders of several dozen patents in encryption technology, provide the background and detail the applications needed to investigate new properties of PNs especially relevant to the improvement of modern wireless systems. They propose a universal architecture involving controlled bit permutation instruction that will permit the performance of both data-driven permutations and an arbitrary prescribed fixed permutation in a single cycle. Because of its simplicity and efficient use of current hardware, the embedding of this architecture is a highly attractive option for CPU manufacturers. Detailing all the relevant information into a single volume,this book makes that option more feasible than ever.


Abstract Critically revisiting the 'equality versus difference' dualism that is inscribed in the feminist canon of the last decades is an important task for feminist ethico-political discussions today. The theoretico-political tension between claims of equality and difference still troubles feminist discussions and thus needs to be addressed by contemporary research. Yet, moving beyond the persisting antagonism cannot be done by either moving outside the problematic relation or by choosing one term over the other. It is, as Joan W. Scott noted, impossible to choose between equality and difference, so that other ways of tackling the problem are needed. This article suggests a new line of flight for feminist politics in respect to this founding paradox from a feminist new materialist/posthuman(ist) perspective. Via an affirmative reading of Irigaray's cosmopolitical concern of Sharing the World (2008) and a critical investigation into the structuring 'anthropological limit' (Derrida) of her sexual difference thinking, the author pushes the dualistic framework of equality versus difference towards a thought of 'nonmimetic sharing' and 'staying with the trouble'. In her argument, she turns to the differential worldings of Grosz's 'differing', Barad's 'quantum' and Haraway's 'terran' in order to open up ethico-political alternatives to engage difference(s) differently. The article ultimately argues that by affirming all multifaceted (im)material worlding entanglements, significant new insights can be gained for both theorizing differentiality as ethico-onto-epistemological 'becoming-with' and for practising this world of/as difference(s) in a more 'response-able' manner.


Multicast routing with multiple QoS constraints has become a very significant research issue in Ad Hoc networks. Most existing ways to deal with the routing problem of multiple QoS have some constraints, such as delay, bandwidth and delay jitter metrics. Compared with the traditional methods, a new network model which can develop a solution to these problems and maximize the lifetime of Ad Hoc networks is described in this paper. Accordingly, a multicast routing protocol based on clustering, MQCR(Multiple QoS Constraints Routing), is proposed. Each intra cluster node only needs to maintain its cluster's routing information, and the each bridge node need to maintain the cluster and the summary information of other same level clusters of this higher level cluster. Extensive simulation studies show the good performance of MQCR, which can provide an effective approach to QoS multicast routing for mobile Ad Hoc networks.


Abstract : The synthesis and characterization of bis(4-t-butyl-pyridine)bis(3,5- di-t-butylquinone)ruthenium is reported. A crystallographic molecular structure determination carried out on the complex has shown that it exists as the trans isomer and that ligand C-O lengths are relatively long for a semiquinone complex being at the bottom end of the range observed for catecholate complexes. Both quinone ligands appear structurally and electronically equivalent. The complex is diamagnetic and shows a well-resolved spectrum. Electrochemically, the complex undergoes four redox processes, all of which most likely involve both metal and quinone ligands. There are charge-transfer bands in the visible region, and an exceptionally intense and structured band in the near infrared region. The ground state is viewed as a mixture of bis(4-t-butylpyridine)bis(3, 5-di-t-bu tylsemliquinone0ruthenium(II) and bis(4-t-butylpyridine)bis(3,5-di-t- butylcatecholato)ruthenium (IV), with the former dominant.


To the Editor: —We have received a large number of letters regarding the compilation of data on hay-fever as a result of an article "Hay-Fever: Its Cause and Prevention" (The Journal, March 4, 1916, p. 707). The American Hay-Fever-Prevention Association desires especially to receive the following data: the sex, age and occupation of hay-fever sufferers, the duration of the disease and date of commencement and ending of the attacks. If a report is obtained from a botanist giving the names of the most common anemophilous plants pollinating during the time of the attack, the information will be more valuable. Attacks of pollinosis frequently cease from a change of wind or other reasons diminishing the supply of pollen or sometimes permanently from changing the residence to a locality removed from the exciting pollens, or from gradually developing immunity, and many remedies are thereforepost hoc, ergo propter hoc. Remedies should therefore


Low‐temperature Pt enrichment is illustrated with reference to two hypogene platiniferous minerals: (i) a Pd–Cu‐bearing 'Pt2HgSe3', an unnamed phase; and (ii) hongshiite, PtCu, with up to 0.7 wt% Hg. The former has patches oxidized to a Pt–O species with curvilinear microcracks originated by desiccation. The latter displays parallel sets of Cu‐depleted, Pt–Hg‐enriched patches, along which microfractures occur. Such microstructures are interpreted to arise from two processes: (i) oxidation and formation of a hydrated Pt–O compound, which tends to succumb to a Pt‐rich alloy by deoxygenation and dehydration, leaving behind curvilinear desiccation cracks; (ii) metal leaching conducive to native Pt by removal of Cu from hongshiite via micropores that coalesce along crystallographic planes to result in reticulated microcracks. Platinum enrichment either by oxidation or metal leaching ideally produces characteristic microcracks, which may be indicative of the origin, i.e. detrital vs. supergene, of alluvial and eluvial Pt‐rich alloys.


Penile amputation is a rare injury, but one which all Plastic Surgeons with a microsurgical interest should be aware of. The majority of cases are seen in acutely psychotic patients who amputate their own penis, and this provides a unique challenge for the treating surgeon. Not only does it present issues with compliance, but also raises the difficult question of whether replantation is in the best interest of the patient.


The mystique of eliteness is a quality that is cultivated or constructed overtime. Here, I examine agency– a culturally-specific, consolidated stream of composite actions and interactions that are geared towards specific social endeavours, and structure -representing conventions and social parameters through which agency and social practices are performed and become performative, by tracing the historical-political context in which Chief Obafemi Awolowo, the acknowledged leader of the Yoruba of Nigeria, rose to politico-cultural prominence and succeeded to the "throne" of the Yoruba progenitor, Oduduwa. I argue that through this succession, Awolowo became the "modern Oduduwa" and the central signifier of Yorubaness in 20th Century Nigeria and beyond.


The continuous model of the linear induction motor (LIM) has been made considering the edge effects and the attraction force. Taking the attraction force into account is im- portant when considering dynamic analysis when the motor operates under mechanical load. A laboratory prototype has been implemented from which the parameters of the equivalent LIM circuit have been obtained. The discrete model has been developed to quickly obtain computational solutions and to analyze non-linear behaviors through the application of discrete control systems. In order to obtain the discrete model of the LIM we have started from the solution of the continuous model. To develop the model, the magnetizing inductance has been considered, which reflects the edge effects. In the results, the model is compared without considering the edge effects or the attraction force with the proposed model.


The effect of a hole on aerodynamic forces acting on a rectangular plate in Stokes flow is shown. The effect does not depend strongly on the area or location of the hole, because the hydrodynamic forces near the hole are increased and because the effect of the hole on the hydrodynamic forces acting on the plate is decreased. This result can be used to decrease the mass of a cantilever in a micro-flow sensor without affecting its characteristics. When this micro-flow sensor is attached to a flapping wing, the decrease in sensor mass is important because inertia acting on the sensor causes deformation of the flapping wing. This result is important in understanding the flight of insects with bristled wings.


The purpose of this paper is to propose an appropriate recycling organic materials system based on ecological cycle. The final target of this research is to evaluate quantitatively the benefit of recycling organic materials and to propose ascenario to construct an appropriate recycling system. In this paper, the mount of some organic wastes from food industries is investigated. The recycling system, in which are the by-products recycled into the food industries, livestock raising and agriculture, is proposed and evaluated from the view point of physical, economic and social conditions which lead the social shift from a one way resource use system to a recycling one. In particular, the relation between the food industries and the livestock raising is simulated according to the change of exchange rate and Chicago corn rate.Finally, an appropriate valance of industry to perform the recycling organic system is considered.


Automating computational workflows leads to more reproducible research. automan assembles a suite of long-running computations, deploys them on your computational resources, and produces final plots from output data, all with a single command.


Paeoniae Radix Alba is the dried roots of Paeonia lactiflora in Ranunculaceae,which contains a variety of chemical composition with physiological effects.Total glucoside from Paeoniae Radix Alba(TGP) is a general term for a group of glycosides substances which is extracted from Paeoniae Radix Alba.The TGP includes paeoniflorin,peony flower glucoside,hydroxy paeoniflorin,benzoyl paeoniflorin,peony lactone glycosides,and so on.The main compositions are paeoniflorin and peony lactone glycosides.Pharmacological and clinical researches find that TGP has anti-inflammatory,immunomodulatory,and analgesic functions.It has been widely applied in a variety of clinical treatment of kidney disease in recent years.This article makes a summary on the the research progress in pharmacological effects and clinical application of TGP in the treatment of kidney diseases.


Exhibition result of ceramic symposium in Hungary. Theme of symposium was "Earth" and was held at the Ceramic Studio in Kecskemet. 13 artists took part from 8 different countries, Hungary, Greece, Canada, West Germany, Switzerland, Finland, Sweden, Norway. Catalogue includes bigraphical information about each artist and a b&w image. Enclosure: invitation card for the exhibition.


The ability to detect sinusoidal spectral envelope from an unmodulated (flat) spectrum has shown a strong correlation with speech perception in quiet and noisy listening conditions in normal hearing, hearing-impaired, and cochlear implant users. In this study, the mismatch negativity (MMN) was collected from 10 normal-hearing adult listeners and used to determine if modulation detection thresholds derived electrophysiologically correlate with the psychophysically measured spectral modulation detection thresholds. MMNs were present for most participants with spectral contrasts of 10 and 20 dB, suggesting that the MMN may be a promising neurophysiologic measure of spectral envelope perception when nonbehavioral measures are desired.


to replace the term ''baboon syndrome'' with the acronym SDRIFE. This condition is characterized by five clinical findings, and the case reported here had all five findings. First, the patient was exposed to celecoxib. Second, the patient presented with sharply demarcated erythema of the gluteal area and V-shaped erythema of the perigenital area. Third, there was involvement of the axillae. Fourth, the lesions were symmetrically distributed. Fifth, there were no systemic symptoms or signs. Thus, the clinical diagnosis of SDRIFE was made. SDRIFE is an adverse cutaneous drug reaction without any known history of previous cutaneous sensitization. According to previous reports, the most common causative agents were antibacterials such as aminopenicillins and b-lactams and chemotherapeutic agents such as mitomycin. Previously reported causes of symmetrical flexural eruption using the term SDRIFE include: penicillin, valacyclovir, telmisartan hydrochlorothiazide, ethyl loflazepate, rivastigmine, risperidone, and iodinated radiocontrast media. This is the first case report of SDRIFE related to celecoxib. Thus, it should be added to the growing list of drugs causing SDRIFE. Patch test is only positive in up to one-half of patients probably because of reduced absorption of drugs to skin, and oral provocation test is found positive in most patients with SDRIFE. This case illustrates an uncommon presentation of a skin-related drug reaction to celecoxib that was confirmed by a provocation test.


Some adolescents confronted with loss develop symptoms of complicated grief, depression, and anxiety. Little is known about mechanisms causing such problems in this group. Cognitive behavioral theories of grief hypothesize that negative cognitions are pivotal in emotional problems after loss. The current preliminary study tested this hypothesis among 30 adolescent girls (13–18 years). Findings showed that different types of negative cognitions were significantly associated with complicated grief and depression severity. Global negative beliefs about life and the self and catastrophic misinterpretations of grief reactions were most strongly linked with symptoms. Findings support cognitive behavioral theories of grief.


Background

Children with type 1 diabetes (T1D) experience poor glycaemic control. Among non-adolescent children, parents assume much responsibility for managing diabetes and attaining blood glucose levels within clinically recommended target ranges. We explored parents' experiences of managing their child's diabetes and reasons for treatment non-adherence in order to identify better ways to support them.

Methods

In-depth interviews with 54 parents of children with T1D (aged ≤ 12 years), recruited from four Scottish paediatric diabetes clinics. Data were …


In this paper, we introduce an economic electrothermal timing steamer for common Carius tube Os in situ distillation. It is suitable for analysing several batches of samples. Its configuration allows the Carius tubes to be properly fixed and bathed in steam into which the tubes are immersed. The top of each Carius tube is sealed with a stretchy rubber head through which a pair of teflon tubes pierce, serving as inlet and outlet for clean air and OsO4 respectively. At steam temperatures of 99–100 °C, OsO4 in the sample solutions inside the Carius tubes is evaporated out and subsequently carried by clean air to the trapping water in an ampoule bottle, immersed in a box filled with ice. In the present study the steamer allowed for the convenient, efficient and simultaneous distillation of Os from seven samples with near ninety percent recovery. The blank values were 0.42 ± 0.15 pg and 0.26 ± 0.05 for 187Os and 187Os/188Os (n = 4). The dating results of reference materials (RMs) namely Henderson, HLP and JDC were in accordance with reference and certified values within the range of uncertainties. The special steamer has successfully been used in the analysis of pyrite samples for the distillation of Os.


Cyhexatin resistance was confirmed in laboratory tests on two strains of Tetranychus urticae Koch from apple and pear orchards in 1981. Another 21 strains from orchards were tested from 1982 to 1985. Cyhexatin resistance was confined mainly to the Goulburn Valley of Victoria (the main pear-growing area in Australia) and the Murrumbidgee Irrigation Area in southern New South Wales, but was widespread in these areas. Three formulations of cyhexatin were used in the laboratory bioassays. A wettable powder formulation gave satisfactory results except with females of more highly resistant strains. The problem was not experienced with an emulsifiable concentrate formulation; therefore, we concluded that levels of resistance in these strains should be based on data obtained with the latter. Levels of cyhexatin resistance did not exceed 15-fold in females of field populations. Laboratory selection with cyhexatin on one of the more resistant strains (ShJ) only marginally increased the level of resistance. Resistance in ShJ did not increase in the field, although 16 cyhexatin sprays were applied in 3 years. In the laboratory, resistance reverted slowly toward susceptibility without miticides (e.g., after ca. 160 generations, resistance to cyhexatin in ShJ fell from 9.1- to 1.9-fold at LC50) and 34.5% of the population still survived in a discriminating concentration. Levels of cyhexatin resistance in larvae were considerably lower than in females. Cyhexatin resistance conferred cross resistance to azocyclotin and fenbutatin oxide.


An optimization methodology that combines high-level exploration with Register Transfer Level (RTL) design for the power-efficient estimation of motion estimation algorithms on a system comprised by an FPGA and an external memory is presented. Low power consumption is achieved by implementing an optimum on-chip memory hierarchy inside the FPGA, and moving the bulk of required memory transfers from the internal memory hierarchy instead of the external memory. A case study of three popular multimedia kernels is performed for a number of different FPGA devices. Comparisons among implementations with and without this optimization, prove that great power efficiency can be achieved while satisfying performance constraints.


Objective To study the relationship between the cyclic AMP-responsive element modulator(CREM) gene and the obstacle of idiopathic spermatogenesis of male infertility.Methods The peripheral blood of 20 patients with idiopathic azoospermia and of 20 volunteers who have the normal fertility was collected.The CREM gene was analyzed with PCR amplification and single-strand conformation polymorphism.The testicular biopsy structure of abnormal CREM gene patients was observed.Results The CREM gene mutation was observed in 13 cases of the patients with azoospermia.The testicular histological structure of the patients with azoospermia was similar to the phenotype of"Only sertoli cells syndrome",or similar to the phenotype of spermatogenesis frozen at different stages of spermatogenic cells.Conclusion The mutation of CREM gene might be related to the obstacle of idiopathic spermatogenesis.


This paper studies a fundamental problem regarding the security of blockchain PoW consensus on how the existence of multiple misbehaving miners influences the profitability of selfish mining. Each selfish miner maintains a private chain and makes it public opportunistically for acquiring more rewards incommensurate to his Hash power. We first establish a general Markov chain model to characterize the state transition of public and private chains for Basic Selfish Mining (BSM), and derive the stationary profitable threshold of Hash power in closed form. It reduces from 25% for a single attacker to below 21.48% for two symmetric attackers theoretically, and further reduces to around 10% with eight symmetric attackers experimentally. We next explore the profitable threshold when one of the attackers performs strategic mining based on Partially Observable Markov Decision Process (POMDP) that only half of the attributes pertinent to a mining state are observable to him. An online algorithm is presented to compute the nearly optimal policy efficiently despite the large state space and high dimensional belief space. The profitable threshold is much lower for the strategic attacker. Last, we formulate a simple model of absolute mining revenue that yields an interesting observation: selfish mining is never profitable at the first difficulty adjustment period, but relies on the reimbursement of stationary selfish mining gains in future periods. The delay till being profitable of an attacker increases with the decrease of his Hash power, making blockchain miners more cautious about performing selfish mining.


'Windham' (Reg. No. CV-27, PI 647868) is a winter feed pea (Pisum sativum L.) developed by the USDA-ARS in cooperation with the Washington Agricultural Research Center, Pullman, WA, the Idaho Agricultural Experiment Station, Moscow, ID, and Central Agricultural Research Center, Montana State University, Moccasin, MT. Windham was approved for release at the spring 2006 meetings of the Washington State University Legume Variety Release Committee and the Montana State University Variety Release Committee. It was released based on superior agronomic adaptation, winter hardiness, and tolerance to harsh winter conditions. Fall-sown peas have higher yield potential, improved effi ciency of fi eld operations, and rotational and agronomic benefi ts in the farming system. Windham originated as an F6 selection from the cross CAH-61/ D258-1-3/2/CAH-61/B686-320-0/3/D258-1-2 made in 1993 by F.J. Muehlbauer. CAH-61 is a winter-hardy green cotyledon pea with a dwarf growth habit and tendrilled leaf morphology conferred by the afi la gene, af. D258-1-3 is a winter-hardy breeding line derived from the cross D19-1-3/Glacier with a dwarf plant habit conferred by the le gene and conventional leaf morphology. B686-320-0 is a multivirus resistant line (Provvidenti et al., 1991) that blooms at the 9th to 10th node, has a dwarf plant habit (le), and bears two white fl owers per peduncle. Additionally, it has the dominant I gene for yellow cotyledons and the recessive r gene for wrinkled seeds. D258-1-2 is a sister line to D258-1-3, having the same phenotypic characters. Windham has a dwarf growth habit and recessive af for tendrilled leaf morphology, resulting in an upright canopy through harvest, improving harvest ease and seed quality (Fig. 1). The improved agronomic performance and canopy structure give Windham an advantage to 'Specter' (McPhee and Muehlbauer, 2007) in many production systems. Vine length averages 57 cm, and the internodes appear in a zigzag manner. Four to six basal branches are typically formed in the fall as a short rosette before entering a winter dormant period. Normal, nonclasping stipules are moderately marbled. Flowering begins at the 18th node. Flowers are white, conferred by recessive a, and usually borne doubly on the peduncles with three fl owers per peduncle observed occasionally. Pods are straight, blunt-ended, and medium green and contain four to six seeds. Seeds are smooth and round with yellow cotyledons. The testa is clear but is characterized by subtle mottling, referred to as "ghost mottling," resulting from the presence of dominant M in the presence of recessive a. Weight of 100 seeds averages 15.0 g. Presence of the subtle mottling and the small seed size make this cultivar undesirable in many edible pea markets for human consumption; however, the relatively small seed size and high yields make it an ideal pea for animal feed. Windham is resistant to race 1 of Fusarium wilt (caused by Fusarium oxysporum Schlecht. emend. Snyd. & Hans. f. sp. pisi) but is susceptible to pea enation mosaic virus and powdery mildew (caused by Erysiphe pisi DC). Windham was tested at 29 site-years over 8 yr in eastern Washington, northern Idaho, Oregon, central Montana, North Dakota, South Dakota, and Wyoming, where average seed yield was 2367 kg ha−1. Windham yielded 2491 kg ha−1 compared with 2270 kg ha−1 for Specter. Windham produced superior yield to Specter in 19 out of 29 head-to-head trials and exceeded the trial mean in 26 of these trials. Yields for Windham ranged from a low of 343 K.E. McPhee and F.J. Muehlbauer, USDA-ARS, 303 Johnson Hall, WSU, Pullman, WA 99164-6434. C.C. Chen and D.M. Wichman, Central Agriculture Research Center, Montana State University, Moccasin, MT 59462. Contribution from USDA-ARS in cooperation with the College of Agriculture and Home Economics, Agricultural Research Center, Washington State Univ., Pullman, WA 99164. Registration by CSSA. Received 22 Dec. 2006. *Corresponding author (firstname.lastname@example.com).


Families of individuals aged 15-24 yr born with cleft lip, with or without cleft palate, and suitable control families were required for a study of inherited predisposition to the malformation. Cleft patients were identified through hospital discharge listings, but the overall yield of participating patients was only 8% of the cases listed. An attempt to recruit control subjects by the same method, using patients who had been hospitalized for dissection tonsillectomy, yielded only 4% of those identified as suitable in the discharge listings. The results highlight the value of specialized, regularly updated disease registers in the recruitment of subjects for research purposes.


sake of convenience, to have broken down a very long unit such as the one Wolff finds in 5:8—7:16? In any event, the plan of the commentary being what it is, to handle such large units makes for a certain unwieldiness and, in particular, has the result that the final heading, "Goal" (that is, theology), tends to be—so the reviewer felt—somewhat broad and general. But these are points upon which no two are agreed, and too much should not be made of them. Let it be said, therefore, that Wolff has given us an excellent commentary, far better than anything that we have on the subject in English. All serious students who have a command of German will want to own it. Indeed, one has seen enough of this series by now to recommend that such students sub scribe to the whole, thereby receiving the various fascicles as they appear, and at an appreciable reduction in price. It may be added that not the least of many pleasing features of this series is the fact that the print (even in the textual notes) is large and clear; one need not ruin one's eyes in the attempt to read it. In the present volume, technical errors noted were few indeed. On page 150, S. V. McCasland appears as McCarland, while on page xxvii f. the work of G. A. Smith on the Minor Prophets is cited twice in the list of literature. If there were other errors. I did not see them. T ^ J O H N BRIGHT


This study examined the association between interpersonal relationships and organisation learning behaviour among new employees; as well as the influence of psychological safety on that relationship. Participants were 1 500 newly recruited university employees (females = 41.66%; mean age = 44.67 years, SD = 8.11 years). Participants completed measures of interpersonal relationship carrying capacity (emotional carrying capacity, tensility, and connectivity), subjective experience (positive regard, mutuality, and vitality), and learning behaviour. Regression analyses indicated that higher interpersonal relationship dimension statuses predicted higher organisation learning behaviour. Psychological safety mediated the influence of interpersonal relationship on organisational learning behaviour. These findings suggest the importance for human resources managers in tertiary institutions to promote psychological safety of new employees for their work adjustment, improved organisational learning, and enhancement of productivity.


This study reviewed cytogenetic analysis in 568 fetal blood samples by cordocenresis from second- and third-trimester pregnancies to identify associated problems with fetus and to confirm abnormal karyotype of cultured amniotic fluid cells. Chromosome abnormality was detected in 80 cases (14.1%) which contained 30 cases (37.5%) of numerical aberration, 30 cases (37.5%) of mosaicism, and 20 cases (25%) of structural aberration. The most frequent abnormality was sex chromosomal mosaicism (23 cases, 28.8%) followed by autosomal trisomy (27.5%) and numerical aberration of sex chromosome (8.8%). Twenty-two cases (27.5%) were consistent with autosomal trisomy including eleven cases of trisomy 18, eight cases of trisomy 21, and three cases of trisomy 13. Among structural aberrations, translocation (7.5%), maker chromosome (0.5%), and addition (0.5%) were prevalent. One of three cases with unbalanced reciprocal translocation and one of two cases with balanced translocation were inherited from male translocation carriers. In order to obtain definitive results, 44 cases with chromosomal aberration in amniotic fluid cells were investigated and 24 cases (54.5%) of them showed the same abnormality in fetal blood. Three of twenty-one cases previously defined as true mosaicism in amniotic fluid cells revealed a normal karyotype in fetal blood. Interestingly, one of three cases with mosaic trisomy 20 is confirmed in fetal blood, whereas the others showed a normal karyorype in fetal blood. Cytogenetic analysis in fetal blood by cordocentesis is necessary for prenatal genetic diagnosis in pregnancies that indicate high risk for fetal abnormalities or present abnormal karyotypes of cultured amniotic fluid cells.


As a sort of MINs (Multistage Interconnection Networks), we propose the 2-dilated baseline network whose performance in the faulty case degrades as gracefully as possible. All the available paths established between an input terminal and an output one via an identical input of SE (Switching Element) in some stage never pass through an identical SE in the next stage. The loads on SEs, therefore, are shared efficiently. Extra links added to enhance the performance never complicate the routing scheme. There is no difference between our MIN and other ones in hardware overhead. Besides our MIN is superior to other ones in performance, especially in robustness against concentrated SE faults in an identical stage.


Purpose: To explore the feasibility and repeatability of a novel glasses-free display combined with random-dot stimulus and eye-tracking technology for screening stereopsis in adults. Methods: A total of 74 patients aged 18–44 years were recruited in this study (male: female, 32:42), including 33 patients with high myopia [≤ -6.0 diopters (D)] and 41 patients with moderate-to-low myopia (>-6.0 D). Stereopsis was measured using glasses-free, polarized, and Titmus stereotests. All patients completed a visual fatigue questionnaire after the polarized stereotest and glasses-free test. Kendall's W and Cohen's Kappa tests were used to evaluate repeatability and consistency of the glasses-free stereotest. Results: The stereotest results using the glasses-free monitor showed strong repeatability in the three consecutive tests (W = 0.968, P < 0.01) and good consistency with the polarized stereotest and Titmus test results (vs. polarization: Kappa = 0.910, P < 0.001; vs. Titmus: Kappa = 0.493, P < 0.001). Stereopsis levels of the high myopia group were significantly poorer than those of the moderate-to-low myopia group in three stereotest monitors (all P < 0.05). There was no significant difference in visual fatigue level between the polarized and the glasses-free display test (P = 0.72). Compared with the polarized test, 56.76% of patients preferred the glasses-free display and found it more comfortable, 20.27% reported both tests to be acceptable. Conclusions: In our adult patients, the new eye-tracking glasses-free display system feasibly screened stereopsis with good repeatability, consistency, and patient acceptance.


Current polymer nanocomposites for energy storage suffer from both low discharged energy density (Ue) and efficiency (η) with increasing temperature due to their large remnant electric displacement (Dr), small breakdown...


*' * tla "fig ■ MII V tkmi dMMibod pmviuuel/^the distribution function of electron energies for electrons in argon and mixtures of hydrogen and argon obtained by a numerical solution of the Boltzmann equation which takes Into account elastic and inelastic collisions. By taking appropriate averages over the distribution function, the electron drift velocity w, magnetic drift velocity w^i and characteristic energy «j^are computed. A comparison of calculated and experimental values of these transport coefficients enables us, in the case of pure argon, to extend the previous work of Frost and Phelps and derive the mooentum transfer cross section from 0.7 to 25.0 eV. The momentum transfer and inelastic collision cross sections derived in this paper for ergon and previously for hydrogen give rise to transport coefficients in mixtures of ch&sc two gases which are consistent with most of the available experimental * This research was suppovtod in part by the Advanced Research Projects Agency through the Office of Naval Research.


The water diffusion mechanism in obsidian has been revisited with the advent of a new dating approach employing secondary ion mass spectrometry (SIMS). The water diffusion SIMS( + ) profile and the concept of a surface saturation (SS) layer in obsidians both provide a sound basis for the new diffusion age equation (SIMS-SS) and are supported by dated world examples (Liritzis et al. 2004). Here, we present the basic physical‐chemical analysis of the mass transport phenomenon on which the new dating method is based. The crucial age parameter of the SIMS-SS dating approach for archaeological obsidians—that is, the surface saturation (SS) layer—is supported by both theoretical and experimental data.


We study nematic configurations within three-dimensional (3D) cuboids, with planar degenerate boundary conditions on the cuboid faces, in the Landau-de Gennes framework. There are two geometry-dependent variables: the edge length of the square cross-section, $\lambda$, and the parameter $h$, which is a measure of the cuboid height. Theoretically, we prove the existence and uniqueness of the global minimiser with a small enough cuboid size. We develop a new numerical scheme for the high-index saddle dynamics to deal with the surface energies. We report on a plethora of (meta)stable states, and their dependence on $h$ and $\lambda$, and in particular, how the 3D states are connected with their two-dimensional counterparts on squares and rectangles. Notably, we find families of almost uniaxial stable states constructed from the topological classification of tangent unit-vector fields and study transition pathways between them. We also provide a phase diagram of competing (meta)stable states, as a function of $\lambda$ and $h$.


The classification study of beetles is of great significance for biodiversity conservation and utilization, agricultural and forestry pest control and other work. In the traditional classification method of beetles, there are problems such as single dimension of extracted features, insufficient feature information, insufficient model accuracy and model generalization, and difficulty in practical application. In order to solve the current problems encountered, this paper proposes an image classification model of Longhorn Beetles of Yunnan based on Bagging and CNN. The model is based on the data set extracted by Gabor filter, constructs LHB-CNN, AlexNet, Xception, InceptionV3, MobileNetV2 to obtain the base classification model. Second, the base model is ensembled through the Bagging ensemble strategy. The experimental results show that the classification model based on Bagging and CNN achieves 99.38% classification accuracy. Compared with the five models of LHB-CNN, AlexNet, Xception, InceptionV3 and MobileNetV2, this method has higher accuracy and precision, and experiments have proved the advantages and better robustness of this method. Therefore, the image recognition model based on Bagging and CNN can effectively classify the images of Longhorn Beetles of Yunnan, and provide certain support for the prevention and control of Longhorn Beetles of Yunnan.


The development of new and renewable energy is currently a top priority for the international community, as energy needs continue to increase while fossil fuels are running low. The Savonius rotor turbine is one of the most widely used turbines but has low efficiency. This study aims to improve the performance of the Savonius turbine by developing a new blade based on airfoil which is simulated in CFD. There are 2 blade models to be simulated, namely the RD-1 model and the RD-2 model, then the simulation results are compared with the conventional blade. The results of the study can be said that the new airfoil-based blade can improve the performance of the Savonius turbine, the increase occurs in the TSR value which is better than the conventional blade. The highest Cp is 0.148 on the RD-2 model blade with a maximum TSR of 0.8


regulated in IKKα KD micromass samples, suggesting a common or concerted regulatory mechanism linked to IKKα. Conversely, MMP-10, recently shown to function as a collagenase activator in OA cartilage, was downregulated in IKKα KD samples. Overall, these findings suggest that IKKα can cooordinately affect a number of different processes, some of which are linked to ECM remodeling, whose deregulated control is associated with OA disease. A subset of the genes affected by IKKα were also differentially expressed in normal vs. OA cartilage. Conclusions: IKKα protein is upregulated in late OA cartilage. In the context of differentiating chondrocytes in in vitro micromasses and on the basis of DNA microarray analysis, the expression of IKKα was linked to a functional profile specifying effectors of ECM remodeling, cell cycle and cellular communication with some of the same genes exhibiting differentially expression in normal vs. OA cartilage. Subsequent experiments will examine the expression profile of these and other IKKα linked genes in OA progression to better understand IKKα's potential role in OA disease onset and and/or development.


Ecopreneurship is an idea that has not been explored by researchers explicitly and become a learning innovation in the 21 st century, but, implicitly this concept is believed that it has been implemented in some primary schools but no further research, therefore, this study aims to prove and to give the description of ecopreneurship development in primary school. This study used a qualitative approach with descriptive method . The subject of this research is 22 teachers in primary school. The results of this research showed that the development of ecopreneurship in primary school was integrated in the curriculum content in schools that have implications to the creation of intracurricular learning, extracurricular learning , and display room based on the ecopreneurship's concept. It is found that 81.2% of teachers have tried to apply the principles of ecology in classroom learning and 54.5% of teachers have tried to associate it with the principle of entrepreneurship. The result of this research became the basis for researchers in conducting further research. In addition, the result of this research is expected to be a reference for primary school teachers to develop current learning in 21 st century and it becomes a preventive effort, especially for Indonesia n society in preparing them to face Indonesia Emas 2045 .


Objective: To identify effects of the C9ORF72 repeat variant on brain atrophy patterns in behavioral variant frontotemporal dementia (bvFTD) and FTD-amyotrophic lateral sclerosis (ALS). Background The GGGGCC repeat in the noncoding region of C9ORF72 was recently found to be a major contributor to genetic risk for FTD and ALS in both familial and sporadic cases. Whether the C9 variant confers specific morphological characteristics to degeneration associated with bvFTD/FTD-ALS is unknown. Design/Methods: Four-hundred-sixteen patients with FTD or related disorders and asymptomatic family members evaluated at UCSF were tested for C9ORF72 expansion (C9+:n=37). DARTEL-based voxel-based morphometry (VBM) analyses of combined gray-white maps were performed on structural MRIs from 25 bvFTD cases (C9+:n=6, C9-:n=19), 9 FTD-ALS cases (C9+:n=5, C9-:n=4), and 164 cognitively normal older adults. Comparisons were analyzed for: bvFTD(C9+) versus controls; bvFTD(C9-) versus controls; interaction of (C9+)x(bvFTD) versus bvFTD(C9-) and controls; FTD-ALS(C9+) versus controls; FTD-ALS(C9-) versus controls; interaction of (C9+)x(FTD-ALS) versus FTD-ALS(C9-) and controls. Results: BvFTD(C9+) cases demonstrated greater lateral parietal (right>left) and bilateral thalamic, and less medial frontal atrophy than bvFTD(C9-) cases. A significant interaction was found where bvFTD(C9+) patients showed greater thalamic (left>right; T=5.00, p FWE =0.05; T=4.05 p uncorr uncorr uncorr left), particularly in the medial occipital lobes and cerebellum, and less medial frontal and brainstem atrophy than FTD-ALS(C9-) cases. A significant interaction was found where FTD-ALS(C9+) cases demonstrated more atrophy in the right superior frontal gyrus (T=4.73, p FWE =0.03), bilateral central sulcus (T=3.67-3.70, p FWE =0.07) and inferior frontal pars triangularis (T=3.58, p FWE =0.07). Conclusions: We found greater posterior and thalamic atrophy in C9+ than in sporadic bvFTDs, and greater posterior and less brainstem atrophy in FTD/ALS(C9+) cases. If confirmed in larger samples, these findings suggest C9ORF72 confers specific atrophy patterns to bvFTD and FTD/ALS with potential clinical ramifications. Supported by: In part by M01-RR0079 General Clinical Research Center; the National Institute on Aging (NIA) grants 5-P01 AG19724 and P50 AG023501; the State of California, Alzheimer9s Disease Research Center of California (ARCC) grant 03-7527; NIH grants R01AG038791, R01AG031278. Disclosure: Dr. Yokoyama has nothing to disclose. Dr. Takada has nothing to disclose. Dr. Sha has nothing to disclose. Dr. Karydas has nothing to disclose. Dr. Khan has nothing to disclose. Dr. Fong has nothing to disclose. Dr. DeJesus-Hernandez has nothing to disclose. Dr. Rutherford has nothing to disclose. Dr. Baker has nothing to disclose. Dr. Rademakers has nothing to disclose. Dr. Coppola has nothing to disclose. Dr. Seeley has received personal compensation for activities with Korea Novartis. Dr. Boxer has received personal compensation for activities with BMS, Plexxikon and Phloronol as a consultant. Dr. Boxer has received research support from Elan, Forest, Genentech, Medivation, BMS, Janssen and Pfizer Pharmaceuticals. Dr. Miller has received personal compensation for activities with Allon Therapeutics, Inc. and TauRx Therapeutics, Ltd. Dr. Miller has received research support from Novartis. Dr. Rankin has nothing to disclose.


Abstract : A rf, electrodeless plasma-generator was developed which operated at peak plasma powers of 50 kw. Th plasma was vortex stabilized, and was contained within a water-cma operating at 400 KILOCYCLES. Master's thesis, by Howard R. Cannon. Aug 62, 71p. incl. illus. tables, 3 refs. (Rept. no. GA/phys/62-2) Unclassified report DESCRIPTORS: *Induction heating, *Plasma physics, Radiofrequency, Instrumentation, Thesis. Identifiers: Energy transfer. A rf, electrodeless plasma-generator was developed which operated at peak plasma powers of 50 kw. Th plasma was vortex stabilized, and was contained within a water-cooled Vycor tube. Power was measured calorimetrically. Radiation power was measured by alternately using clear water and water made opaque with India ink to cool the Vycor tube. A model temperature profile was deduced from spectrographic measurements transverse to the plasma axis. Maximum plasma temperatures were shown to exist in a thin cylindrical sheath near the plasma surface, with relatively cooler temperatures existing at the center-line gas back-flow. Effects of changing gas flowrate, gas composition, rf power, and Vycor tube diameter on the effectiveness of the energy coupling mechanism are shown.


Spraying comparison experiments were conducted on a press pump test-bed,and combustion and emission performance comparison experiments between biodiesel and diesel were done on a single cylinder direct-injected diesel engine. The diameter size distribution of liquid drop and the characteristic parameters of fuels were analyzed,the combustion and emission difference between diesel and biodiesel and the reasons were studied. Study result indicates that,compared with diesel,the spray angle of biodiesel is smaller,the total amount of drop is less,the proportion of small diameter drop is lower,and the maximal diameter is larger. When rotation speed is 1 500 r·min-1 and average effective pressure is 0.531 MPa,the maximal combustion pressure,and the pressure increase ratio and heat release ratio of biodiesel decrease by 1.91%,30.10% and 29.32% respectively,continual combustion period of biodiesel is longer. When rotation speed is 1 500 r·min-1,the emissions of HC,CO and smoke for burning biodiesel decease by 17.17%,26.73% and 37.85% respectively,and the emission of NO increases by 21.93%. 2 tAbs,10 figs,12 refs.


Hypothesis / aims of study Over the period from 1980 to 2025, the population aged 60 years and over in Latin America and the Caribbean is expected to at least double in size and, in more than half of these countries, to triple in size, before reaching the year 2025. This rapid and accentuated aging of the population will have a significant impact on social, economic and health demands. Prominent among the health demands will be those relating to chronic diseases and their incapacitating sequelae and other complaints such as urinary incontinence (UI), which are all included among the so-called "giants of geriatrics", given their negative consequences on quality of life (QOL) among elderly people. The aims of this study are to investigate the prevalence of complaints of UI among elderly and their associated and risk factors for UI.


On the basis of the previous study8,9 on the cell interaction between malignant tumor cells and other cells, especially with lymphocytes, the present study was carried out by investigating cell to cell interaction of human malignant tumor cells and human lymphoblastoid cells such as T‐cell (MOLT‐4 cell) and B‐cell (Burkftt lymphoma cell).


Vocational colleges often neglect the ideological and political education of their students because they attach importance to the skills training of their students. However, it is undeniable that vocational college students will occupy a considerable proportion of the job market in our country, and the ideological and political education they receive at school also determines their future career development to a certain extent. Therefore, vocational colleges should pay more attention to students' ideological and political work and improve their ideological quality.


Abstract The shape of gold crystals inside sapphire has been studied by transmission electron microscopy. 400 keV gold ions were implanted into sapphire (α-Al2O3) at a substrate temperature of 1200°C. The gold ions precipitate as small crystals, which have an ordinary f.c.c. structure and dimensions less than 60 nm. The small gold crystals clearly have faceted outlines. The sides of the outlines are parallel to low-index crystal-planes of sapphire. It has therefore been concluded that the shape of the gold crystals is characterized by the foreign crystal (i.e., sapphire), and that the shape should be a tetradecahedron which consists of two {0001} and twelve planes of sapphire.


INTRODUCTION TO ENVIRONMENTAL TOXICOLOGY AND ITS ROLE IN ENVIRONMENTAL DECISION MAKING Environmental Toxicology as an Interdisciplinary Science A Brief History of and Organizations in Environmental Toxicology Interactions and Connections of Environmental Toxicology to the Management of Ecological Systems Legislation Use of Models in Environmental Science Introduction to the Textbook References Study Questions A FRAMEWORK FOR ENVIRONMENTAL TOXICOLOGY Classical Viewpoint for Classifying Toxicological Effects Alternative Framework Incorporating Complexity Theory Spatial and Temporal Scales Combining Scale and Ecological Dynamics:The Hierarchical Patch Dynamic Paradigm References and Suggested Readings Study Questions AN INTRODUCTION TO TOXICITY TESTING The Dose-Response Curve Standard Methods Classification of Toxicity Tests Design Parameters for Single Species Toxicity Tests Overview of Available Statistical Methods for the Evaluation of Single-Species Toxicity Tests The Design of Multispecies Toxicity Tests Summary of Design Guidelines for Multispecies Toxicity Tests References and Suggested Readings Study Questions SURVEY AND REVIEW OF TYPICAL TOXICITY TEST METHODS Single Species Toxicity Tests Animal Care and Use Considerations Multispecies Toxicity Tests Summary References and Suggested Readings Study Questions Appendix: The Natural History and Utilization of Test Species ROUTES OF EXPOSURE AND MODES OF ACTION The Damage Process Atmospheric Pollutants and Plants Mechanisms of Action Common Modes of Action in Detail Introduction to QSAR Receptor Mediated Toxicity, Endocrine Disruption, and a Mechanistic SAR Analysis of PCB Toxicity References and Suggested Readings Study Questions FACTORS MODIFYING THE ACTIVITY OF TOXICANTS Introduction Physicochemical Properties of Pollutants Environmental Factors Interaction of Pollutants Toxicity of Mixtures Mixture Estimation System 11 Estimating the Toxicity of Polynuclear Aromatic Hydrocarbons Biological Factors Affecting Toxicity References and Suggested Readings Study Questions INORGANIC GASEOUS POLLUTANTS Sulfur Oxides Nitrogen Oxides Ozone Carbon Monoxide References and Suggested Readings FLUORIDE AS A CONTAMINANT OF DEVELOPING ECONOMIES Environmental Sources and Forms Of Fluoride Industrial Sources of Fluoride Pollution Effects On Plants Effects on Animals Effects On Human Health Biochemical Effect References and Suggested Readings Study Questions HEAVY METALS Lead Cadmium Mercury Study Questions References and Suggested Readings BIOTRANSFORMATION, DETOXIFICATION, AND BIODEGRADATION Introduction Metabolism of Environmental Chemicals: Biotransformation Microbial Degradation Bioremediation Isolation and Engineering of Degradative Organisms The Genetics of Degradative Elements An Example of a Detoxification Enzyme-the OPA Anhydrolases References and Suggested Readings Study Questions Measuring and Predicting the Responses of Ecological Systems to Toxicants Introduction Measurement of Ecological Effects at Various Levels of Biological Organization Molecular and Physiological Indicators of Chemical Stress Biomarkers Population Parameters Assemblage and Community Parameters Interpretation of effects at the Population, Community and Ecosystem Levels of Organization Community and Ecosystem Effects Application of Multivariate Techniques Pollution-Induced Community Tolerance Interpretation of Ecosystem Level Impacts An Alternative Model: The Community Conditioning Hypothesis The Problem of the Reference Site References and Suggested Readings Study Questions ECOLOGICAL RISK ASSESSMENT Introduction Basics of Risk Assessment Ecological Risk Assessment Ecological Risk Assessment Framework Risk Characterization Developments in Ecological Risk Assessment A Ranking Approach to Multiple Stressor, Wide Area Ecological Risk Assessment A General Model For Regional Risk Assessment - The Ten Steps Life Cycle Assessment as a Decision Making Tool References and Suggested Readings Study Questions Appendices Index


Digital document management needs control the lifecycle of documents in an organization are created, reviewed, published, and accessed. With Microsoft Office SharePoint Server 2007, it is possible to enforce appropriate policies at every step of the document lifecycle, use centralized repositories for storing, managing, and accessing documents, and efficiently tracking documents. Organization can control how to use documents between Internal and external with AD RMS to protect sensitive Information.


A current question of considerable interest to both the medical and nonmedical communities concerns the number of human transcription units (which, for the purposes of this paper, are "genes") and proteins. Even with the recent announcement of the completion of the draft sequence of the human genome, it is still extremely difficult to predict the number of genes present in the genome. There are several methods for gene prediction, all involving computational tools. One way to approach this question, involving both computation and experiment, is to look at copies of fragments of messenger ribonucleic acid (mRNA) called expressed sequence tags (ESTs). The mRNA comes only from a gene being expressed, or translated, into RNA; by clustering mRNA fragments, we can try to reconstruct the expressed gene. While the final result is a very rough representation of the "true expressed transcript," it is probably within 20% of the real number. Here, we review the issues involved in EST clustering and present an estimate of the total number of human genes. Our results to date indicate that there are some 70000 transcription units, with an average of 1.2 different transcripts per transcription unit. Thus, we estimate the total number of human proteins to be at least 85000. The total number of proteins will be higher because of post-translational modification.


Scientific culture is a kind of cultural attitude for human beings to master the whole world,which is different from religious attitude and experimental attitude.It essentially regulates the human ability to recognize and change the world,prescribes the scope,degree and manner of exchanging material.Energy and information between human and world outside,and stipulates the human development finally.Therefore,it is not only wrong,but also harmful to neglect and deny the positive significance of scientific culture or even regard it as something inhibiting human development.


Future Combat Air Systems are a major stake for the coming decades, and yet the United Kingdom and France have committed to competing projects. Developments in Industry 4.0 could nevertheless offer much needed and relevant convergences to preserve European independence.


Introduction: In DECLARE-TIMI 58, the SGLT-2 inhibitor, dapagliflozin reduced the risk of the composite of cardiovascular death (CVD) or hospitalization for heart failure (HHF), and renal-specific ...


Abstract The compositions of essential oils obtained from the stem barks of two Acacia species namely Acacia nilotica L., and Acacia albida Delile., of the Leguminosae family are reported. The oils obtained by hydrodistillation were analyzed for their constituents by means of GC-FID and GC/MS. Of the 36 compounds of A. nilotica, menthol (34.9%) and limonene (15.3%) were the two quantitatively significant constituents. α-Pinene (18.6%) was the only abundant compound among the 37 constituents of A. albida oil. The results differed considerably from previous data on the oil constituents of some previously studied Acacia species.


A field population (SERD3) of Plutella xylostella L. collected in December 1994, and resistant to various insecticides, including Bacillus thuringiensis subsp. kurstaki (Btk) and B.t. subsp. aizawai (Bta), was selected with Btk (Btk-Sel) and Bta (Bta-Sel). Little evidence of cross-resistance was observed. Binding to midgut brush border membrane vesicles was examined for insecticidal crystal proteins specific to Btk [Cry1Ac], Bta [Cry1Ca] or to both [Cry1Aa and Cry1Ab]. In SERD3 (c. 50 and 30-fold resistance to Btk and Bta), specific binding of Cry1Aa, Cry1Ac and Cry1Ca was similar compared with a susceptible population (ROTH) but binding of Cry1Ab was minimal. The Btk-Sel (c. 600 and 60-fold resistance to Btk and Bta) and Bta-Sel (c. 80 and 300-fold resistance to Btk and Bta) populations lacked binding to Cry1Ab but in Bta-Sel binding of Cry1Ca was similar to ROTH. The results suggest reduced binding of Cry1Ab can partly explain resistance to Btk and Bta. However, the binding of Cry1Aa, Cry1Ac and Cry1Ca in resistant populations, and the lack of cross-resistance between Btk and Bta, also suggests additional resistance mechanisms are present.


Cardiac cath lab is one of the major revenue generating department of the hospital, so it must be managed properly.


We calculate numerically the magnitude of the induced thermomagnetic field due to particle-hole asymmetry in heavy-fermion superconductors. Close to the transition temperature and for a phase shift of the order of {delta}{sub {ital N}}=0.9{pi}/2, this field can be as high as 10{sup {minus}2} G for pure samples. The experimental detection of these induced fields and their orientation dependence can be of great help in identifying the internal structure of the order parameter in these exotic superconductors.


Hydrophobically modified biopolymer derivatives are formed by grafting hydrophobic chains on biopolymer skeletons at various substitution ratios. Depending on the chemical nature of the chain and on the degree of substitution different functional properties may be obtained. For example when a small fraction of long hydrophobic alkyl chains are attached to the hydrophilic backbone of a polysaccharide, the resulting polymer in aqueous solution becomes a rheology modifier. Alternatively, when a large fraction of short hydrophobic chains are grafted on the polysaccharide backbone the resulting polymer becomes amphiphilic with specific emulsifying and foaming properties.


ABSTRACT This paper presents investigations on the effectiveness of repeated washing in removing heavy metals from contaminated Foundry Sand (FS) sample collected from a recycling company in Melbourne. It is found that after repeated wash-offs, concentrations of heavy metals reduce significantly and these reductions for all the tested metals follow logarithmic trends. Results are compared with other contemporary findings on the physical separation of heavy metals from contaminated soil. Also, it is observed that higher the concentration of metals found in the initial leaching solution, higher the rate of reduction of concentration in subsequent leaching. Using logarithmic relationship, best-fit equations for the reductions of heavy metals' concentrations through repeated wash-offs were derived. Using such equations, it is possible to work out a number of washing cycles required for a particular heavy metal to wash it up to the requirement of any particular regulatory authority. In regards to the effect of soil depth on accumulated pollutants' concentrations, it is found that the concentrations of heavy metals in the leachate linearly vary with the depth of FS column used for testing.


Jewish cosmopolitanism has long assumed a central place in the ideology of anti-Semitism. Well before the publication of "The Protocols of the Elders of Zion," the idea of international Jewish solidarity served as an argument against Jewish emancipation. In Britain, Sir Robert Inglis famously opposed granting the Jews political rights because "[t]he Jews of London have more sympathy with the Jews resident in Berlin or Vienna than with the Christians among whom they reside." Likewise, in 1840, the ultramontane Univers saw international lobbying on behalf of Jews accused of ritual murder in Damascus as proof that "the Hebrew nationality is not dead … What religious connection is there between the Talmudists of Alsace, Cologne or the East, and the Messrs. Rothschild and Crémieux?" That L'Univers saw this cosmopolitan fellow-feeling as an expression of Jewish national identity is irrelevant. The point is rather that for anti-Semites Jewish 'nationalism' was an inherently international force.


In the October 1976 issue of this journal Kau and Sirmans (K-S) point out that return repeat and new migrants may behave differently in making their migration decisions and therefore specification (aggregation) bias may result if these three "migrant types" are indiscriminately combined. This is a valid point—in fact others have also made it and shown it to be true —but K-S shed little light on why and how these groups might behave differently and their empirical work suffers from a number of serious flaws that make it virtually incapable of telling us whether these groups do indeed exhibit different behaviors. (In fact in both their Model and Results sections K-S seem more concerned with the differences between blacks and whites than with differences among the three migrant types they set out to investigate.) (excerpt)


In this article, the main topic is how to combine the EPIC and multithreading technologies, which will be the roadmap for the next generation of processor micro-architecture.


The Joy of Statistics consists of a series of 42 "short stories," each illustrating how elementary statistical methods are applied to data to produce insight and solutions to the questions data are collected to answer. The text contains brief histories of the evolution of statistical methods and a number of brief biographies of the most famous statisticians of the 20th century. Also throughout are a few statistical jokes, puzzles, and traditional stories. The level of the Joy of Statistics is elementary and explores a variety of statistical applications using graphs and plots, along with detailed and intuitive descriptions and occasionally using a bit of 10th grade mathematics. Examples of a few of the topics are gambling games such as roulette, blackjack, and lotteries as well as more serious subjects such as comparison of black/white infant mortality rates, coronary heart disease risk, and ethnic differences in Hodgkin's disease. The statistical description of these methods and topics are accompanied by easy to understand explanations labeled "how it works."


Control of the pH level is of vital importance in many industrial applications. However, pH control has only met with limited success. A stumbling block is the severe non-linearity of titration processes. One control strategy that have been employed to overcome the process non-linearity exploits the knowledge that certain pH processes can be casted in the Wiener model structure. In practice, it is very likely that the process characteristics will be affected by the presence of unknown buffers. This paper aims at examining whether there are merits in using structural information to design the architecture of adaptive controllers in situations where the knowledge may be inaccurate due to changing buffering conditions. The main finding of this work is that a "black box" controller is better able to adapt to the changing dynamics caused by the introduction of an unknown buffer.


INTRODUCTION The decision in Metro-Goldwyn-Mayer Studios Inc. v. Grokster, 125 S. Ct. 2764 (2005) pitted the movie and music industries, owners of copyrighted works, against several defendants whose business model is to promote free trading of unlicensed works on the Internet. The decision revisited standards of third-party liability for copyright infringement by technology providers who enable sharing of unlicensed works among end users--a process decried by copyright owners as piracy. The direct trading of unlicensed, copyrighted material among end-users is known as peer-to-peer (P2P) file sharing. Although the High Court ruled in favor of the copyright owners, the decision considered and addressed a number of competing interests. The broader issue at stake in Grokster involves the scope of liability for technology innovators whose technology may be used for both infringing activities and noninfringing uses. In other words, where should the line be drawn between the risk of liability and the reward for innovation? The seed of this debate began twenty years ago in Sony Corp. of America v. Universal Studios, Inc., 464 U.S. 417 (1984), when the Supreme Court announced a doctrine protecting innovators whose technology can be used for infringing and noninfringing uses. That case concerned the manufacturer of the Betamax. In short, the Sony defense immunized manufacturers against third-party liability for copyright infringement when the technology at issue could be used for both legitimate and infringing purposes. However, ambiguities in how the circuit courts interpreted Sony in P2P cases during the past five years led the Supreme Court to grant certiorari in Grokster. The technology provided by the Grokster defendants, known to the public as KaZaa, FastTrack, and Morpheus, represented the next wave of P2P technology after Napster. In July 2001, the Ninth Circuit famously slapped Napster, the company that facilitated free sharing of songs electronically over the Internet, with liability for massive infringement by end-users. (1) Shortly thereafter, the original Napster folded, (2) and new forms of P2P technology emerged in its place. Like Napster, the Grokster defendants offered file sharing for free. However, the Ninth Circuit found the more decentralized technology at issue in Grokster a fundamental difference from the architecture at issue in Napster. The Ninth Circuit declined to impose liability based on this key technological difference, concluding, ipso facto, and despite record evidence to the contrary, that the Grokster defendants lacked control over the infringing activity on their network. (3) In a previously published article in this journal, I argued that the Ninth Circuit inappropriately discounted abundant evidence of intent to facilitate infringement: the article concluded, "[r]estoring some focus on the intent of the actors involved makes eminent sense in sorting out contributory infringement liability in the post-Napster world." (4) I also argued that the Ninth Circuit placed too much emphasis on the decentralized structure of technology in assessing whether to impose third-party liability for copyright infringement, wrongly elevating the format of a technology over the intent of the inventors. (5) The Supreme Court's opinion embraced precisely those points. However, it did so without redefining any of the parameters of the Sony defense, as the interested public had anticipated. Instead, the Supreme Court unanimously found liability based on a theory of "inducement"--a concept borrowed from patent and common law, in which evidence of intent to facilitate infringement is paramount. At the same time, the High Court unanimously declined to further clarify the triggering point for Sony's immunity from liability for copyright infringement by third parties. The ruling presented the inducement theory as if it were entirely disjoined from the Sony defense. In this article, I argue that the Supreme Court struck far more of a balance among competing interests than the 9-0 ruling reversing summary judgment for the technology providers suggests at first blush. …


Abstract Background Emerging antimicrobial resistance is a leading cause of patient morbidity/mortality worldwide. A potential strategy in the treatment of resistant infections is the use of combination antibiotics, with the hope of achieving greater in vitro activity, including synergy. It is currently assumed that combinations generating the greatest synergistic effect in vitro will be associated with the greatest improvement in in vitro susceptibility (as defined by EUCAST—see Methods). The aim of this study was to determine if this was indeed the case. Methods We systematically determined the relationship between double β-lactam therapy against 7 Escherichia coli strains of variable resistance in vitro (4 clinical/3 purchased). This included fully susceptible and low-level resistance isolates (N = 4), extended-spectrum β-lactamase producers (ESBLs) (N = 2) and carbapenemase producers (CPEs) (N = 1). For each of 10 β-lactam antibiotics, the MIC was determined individually, and subsequently in combination, using the MTS™ 'cross' synergy method (Liofilchem, 2012). The fractional inhibitory concentration (FIC) was calculated by dividing the MIC of each drug in combination by the MIC of each drug alone and adding the results. See Figure 1. Results were analysed according to EUCAST clinical breakpoints to determine if synergistic combinations correlated with a potentially improved in vitro susceptibility phenotype. A susceptibility phenotype improvement was defined: R/R or R/I or I/I monotherapy, improving to R/S, I/S or S/S combination therapy (where S = susceptible, I = intermediate and R = resistant). Results Overall, 86/630 (13.7%) combinations showed synergy; 408/630 (64.7%) = additive; 136/630 (21.6%) = indifferent. No antagonism was identified. Synergy was most detected in ESBL producers (32% of combinations; Figure 2) and less frequently in CPEs (2% combinations) and fully susceptible isolates (4% combinations). 31/630 (5%) combinations showed improvement in EUCAST susceptibility between mono/combination therapy (according to our definitions). Of these 31 combinations, 8 (26%) were synergistic, 15 (48%) additive and 8 (26%) indifferent (by FIC index). Of 599/630 combinations that showed no improvement in susceptibility, 78 (13%) = synergistic, 393 (65.6%) = additive and 128 (21.4%) = indifferent. It is however important to note that in 284/630 (45%), initial monotherapy susceptibility was S/S (i.e. further improvement not possible). Synergy was more common in combinations that improved EUCAST susceptibility versus those that did not; χ2, P = 0.04). Ceftazidime/avibactam + amoxicillin was the combination most commonly associated with synergy (12/86 synergistic combinations). Conclusions In the β-lactam combinations tested, synergy or additive effects were common (78.4%), similar to our previous work with Fosfomycin/β-Lactam combinations (89%), but higher than fosfomycin/non-β-lactam combinations (28%). Synergy was most detected in ESBL producers with most synergistic combinations containing one/two β-lactamase inhibitors. Overall, however, this rarely leads to an improvement in in vitro susceptibility by EUCAST criteria and is highly bug–drug–drug combination dependent. Further work using alternative validating methodology and in more isolates is required.Figure 1. MTS™ 'cross' synergy method (Liofilchem, 2012).Figure 2. β-Lactam antibiotics in combination versus 7 E. coli isolates of variable resistance in vitro.


ABSTRACT This paper critically explores the pedagogy of Science World in creating disciplined, birthing patients within the sexuality education BodyWorks gallery on display in Vancouver, Canada. Using Multimodal Critical Discourse Analysis, I explore the ways in which power/knowledge circulates to regulate and de-agentalise bodies in a science museum encounter. I consider the regimes of truth that emerge regarding the good/right/correct way to give birth and to be a woman: that is, as White, heteronormative, slender, conforming, always a mother, but and mostly a uterus. In exposing regimes of truth within the encountered curriculum of the science museum, the hope is that sexuality educators might (re)consider space for the unruly and awe-ful within pedagogies of childbirth.


Recently, web search query information has been applied in advanced predictive model research. Google dominates the global web search market in the Korean market; however, Naver possesses a dominant market share. Based on this characteristic, this study intends to compare the utility of the Korean web search query information of Google and Naver using predictive models. Therefore, this study develops three time-series predictive models to estimate the youth unemployment rate in Korea using the ARIMA model. Model 1 only used the youth unemployment rate in Korea, whereas Models 2 and 3 added the Korean web search query information of Naver and Google, respectively, to Model 1. Compared to the predictability of the models during the training period, Models 2 and 3 showed better fit compared with Model 1. Models 2 and 3 correlated different query information. During predictive periods 1 (continuous with the training period) and 2 (discontinuous with the training period), Model 3 showed the best performance. During predictive period 2, only Model 3 exhibited a significant prediction result. This comparative study contributes to a general understanding of the usefulness of Korean web query information using the Naver and Google search engines.


We present measurements of the Minkowski functionals extracted from the SDSS-III BOSS catalogs. After defining the Minkowski functionals, we describe how an unbiased reconstruction of these statistics can be obtained from a field with masked regions and survey boundaries, validating our methodology with Gaussian random fields and mock galaxy snapshot data. From the BOSS galaxy data, we generate a set of four density fields in three dimensions corresponding to the northern and southern skies of LOWZ and CMASS catalogs, smoothing over large scales (Gaussian smoothing scale of 35 Mpc) such that the field is perturbatively non-Gaussian. We extract the Minkowski functionals from each data set separately, and measure their shapes and amplitudes by fitting a Hermite polynomial expansion. For the shape parameter of the Minkowski functional curves a 0, that is related to the bispectrum of the field, we find that the LOWZ-South data presents a systematically lower value of a 0 = −0.080 ± 0.040 than its northern sky counterpart a 0 = 0.032 ± 0.024. Although the significance of this discrepancy is not very high, it potentially indicates some systematics in the data or that the matter density field exhibits anisotropy at low redshift. By assuming a standard isotropic flat ΛCDM cosmology, the amplitudes of the Minkowski functionals from the combination of northern and southern sky data give the constraints Ωc h 2 n s = 0.110 ± 0.006 and 0.111 ± 0.008 for CMASS and LOWZ, respectively, which is in agreement with the Planck ΛCDM best-fit Ωc h 2 n s = 0.116 ± 0.001.


This work was supported by the EU Seventh Framework Program (223062). The Division of Pharmacoepidemiology & Clinical Pharmacology has received unrestricted funding from the Netherlands Organization for Health Research and Development (ZonMW), the Dutch Health Care Insurance Board (CVZ), the Royal Dutch Pharmacists Association (KNMP), the private/public-funded Top Institute Pharma (www.tipharma.nl; includes cofunding from universities, government, and industry), the EU Innovative Medicines Initiative (IMI), the EU Seventh Framework Program (FP7), and the Dutch Ministry of Health and Industry (including GlaxoSmithKline, Pfizer, and others).


The first chapter deals with corporatism, designed as a model of representation of interests of
different economic actors oligopoly based about few representative organizations of a public nature.
It shows how, after the removal of some thirty years, more due to an antifascist than an actual give
up completely of the concept, the term corporatism appears again in the early eighties as a result of
concerted practices between government, unions and associations business.
The following chapter contains the core of the thesis. Is exploring the nature of social
partnership: the evolution of the model and the search for its legal foundations. Illustrates the
difficulty, in the absence of specific legislative references, to find a definition of dialogue that
contains all the nuances of the relations of trade union participation in negotiations with the
authorities. It is clear that consultation is vague concept in both the sociological and legal terms.
The interdisciplinary approach of the phenomenon defines the most varied forms of negotiation
with the unions complicating the definition.
In the following chapter discusses the link between consultation and collective bargaining when
the State attempts to inform the social partners the lines of cost containment and level of the salary
to be defined in negotiations. From this perspective we can appreciate how the social partnership
has been established also in terms of help, or prepare for a negotiation response to periods of
economic crisis or implementation of the information contained in the reforms of the legislation.
The last part of the thesis looks at new models of social partners involvement in decision-making
in the economic and social development. In particular, reference is made, first, to the model of
social dialogue as it has developed at Community level, on the other hand, the idea of playing a
national model of collective relations based on the need to achieve levels of competitiveness and
productivity, combined with increased rates of employment.
Finally are taken into account the guidelines of the White Paper on European Governance and
the impact on EU and national employment law.


It has been tested that the electrical parameters of quartz crystal resonator are measured by zero phase technique in a π network. And the frequency generator which is the basic equipment of the method has been designed by using direct digital synthesize technique. The result of the measurement of some quartz crystals whose frequency range from 1 MHz to 120 MHz shows that the repeatability of the resonance frequency and the equivalent series resistance can attain ±5×10 -7 and ±5% respectively.