This article examines how research on agriculture and agribusiness mobilizes the concept of Innovation System (IS). The literature review on IS provides an analytical framework that distinguishes the theoretical background, the scope and the social uses of this concept. Based on this framework, a bibliometric analysis on international scientific journals in innovation and agriculture reveals the existence of four knowledge communities that question differently the specific character of innovation and IS in this sector. The current challenge is to promote exchanges between these communities, particularly between the community which applies the evolutionary approach to the agri-food sector, and the epistemic community which seeks to build its own concepts emanating from rural sociology, economics of development and the farming system approach.


Hepatic artery chemotherapy for unresectable liver tumors requires an even distribution of the drugs in the tumor or vascular bed. This cannot be determined angiographically because the drugs are infused at a much lower rate than the contrast media. It is easy, however, to determine the quality of the perfusion by injecting a small volume of Tc-99m MAA in one of the side ports while chemotherapeutic agent is being infused at the same rate. Usually this shows a uniform, satisfactory distribution of isotope. Occasionally, however, some areas fail to receive Tc-99m in spite of what appears to be a good position of the catheter tip. Since ''streaming'' of the infused drugs has been blamed for their uneven distribution, the authors decided to compare the usual steady flow infusions with infusions made pulsatile by the addition of a pulsing device (Gianturco Pump) attached to the infusion tubing. Eighty-three patients were studied with steady as well as pulsatile infusions. In 16 of these patients the perfusion pattern was definitely changed by the pulsatile infusion. In one patient the pulsatile mode resulted in an unwanted gastric perfusion. In 5 patients the distribution was improved in one hepatic lobe and in 10 patients itmore » was improved in both lobes. These results show that hepatic artery perfusions can occasionally be improved by pulsing the infusate. However, pulsing can produce the unwanted perfusion of extra-hepatic areas.« less


A newtype liquid modifier for sodium silicate was developed in this paper. On the basis of exploration experiments ,then cubic simplicial barycentric method of mixture regression design was used,the ternarycomposition modifier was originally developed. Adding this modifier when mixing sands,it can increase the storage strength after gassing of CO2 sodium silicate bonded sands by 50%,and decrease the residual strength after casting by 50% also.\=


An important challenge in machine learning is to find ways of learning quickly from very small amounts of training data. The only way to learn from small data samples is to constrain the learning process by exploiting background knowledge. In this report, we present a theoretical analysis on the use of constrained logistic regression for estimating conditional probability distribution in Bayesian Networks (BN) by using background knowledge in the form of qualitative monotonicity statements. Such background knowledge is treated as a set of constraints on the parameters of a logistic function during training. Our goal of finding the appropriate BN model is two-fold: (a) we want to exploit any monotonic relationship between random variables that may generally exist as domain knowledge and (b) we want to be able to address the problem of estimating the conditional distribution of a random variable with a large number of parents. We discuss variants of the logistic regression model and present an analysis on the corresponding constraints required to implement monotonicity. More importantly, we outline the problem in some of these variants in terms of the number of parameters and constraints which, in some cases, can grow exponentially with the number of parent variables. To address this problem, we present two variants of the constrained logistic regression model, M2b CLR and M3 CLR, in which the number of constraints required to implement monotonicity does not grow exponentially with the number of parents hence providing a practicable method for estimating conditional probabilities with very sparse data.


This contribution aims to examine the competences of the European Parliament in the procedure for concluding international agreements and, therefore, the importance of this Institution in the development of relations between Switzerland and the European Union since the Lisbon Reform. The author starts by outlining the parliamentary competences during the conclusion of international agreements procedure according., firstly, to article 218 TFEU, and secondly, to the Framework Agreement adopted in 2010 between the European Commission and the European Parliament. Subsequently, the degree of involvement of the European Parliament in the relations between Switzerland and the European Union since the entry into force of the Treaty of Lisbon is more precisely analysed. In the author's view, the Lisbon Reform has definitely strengthened the position of the European Parliament. However, thus far, that evolution has not been truly observed under the Swiss-EU relations.


This study aim to investigate the physicochemical and sensory attributes of watermelon rind flour incorporated steamed cupcakes. The produced watermelon rind flour using hot-air drying at 40, 60˚C and freeze drying were substituted for plain flour at 10% level to produce CR40, CR60, and CRFD, respectively. Steamed cupcake without watermelon rind flour served as control (CCONT). Proximate results showed that composite steamed cupcakes had significantly (p<0.05) higher ash, crude fat, and crude fibre contents but lower crude protein, total carbohydrate, and calorie values than control. CRFD steamed cupcakes showed lighten crust and crumb and greater volume and specific volume. However, it shows harder texture but springier crumb than the CCONT. Sensory evaluation results showed that all steamed cupcakes with or without containing 10% watermelon rind flour were considered acceptable by the panellists. It can be concluded that watermelon rind flour dried using freeze drying method improved the nutritional quality and texture properties of steamed cupcakes.


discourse to non-linguistic master's students. The characteristics of educational coworking are revealed. The specified new educational technology is defined as a systematic way of designing, carrying out, and evaluating the total process of learning and teaching in terms of specific objectives. The purpose, objectives, content and principles of the coworking technology are defined. Next, the methodology for the implementation of project-based research coworking is described. It is known that teaching communication in a foreign language is teaching to master, create and use discourses. The authors propose to implement the teaching framework based on the following interrelated principles: the principle of professional orientation, the principle of communicative orientation, the principle of cognitive orientation, the principle of learner-centered learning, the principle of problem-based learning. The content basis of instruction is the scientific and academic discourse. The purpose of teaching is achieved through a combination of various teaching methods, in par-ticular the project-based method, the problem-based method, information technologies, collaborative learning, and traditional communicative methods. Project work is student-centered and driven by the need to create an end-product. The authors identi-fy some specific features of ESP teaching based on the project-based research coworking technology and describe the methodology of its implementation.


Akshaya , a flagship rural e-governance programme of the Government of Kerala implemented since 2002 has been passing through several constraints. Started with high ambitions and targets, the project at present is really at cross roads. Most of the objectives of the project could not be accomplished even after the completion of almost eight years of its implementation. The number of Akshaya e-kendras has been drastically closing down. The avowed objective of providing e-literacy to at least one member of the families is still a dream. If we rely on the recent report of the Comptroller and Auditor General of India (2009) one can see that only 28.62 lakh (41 per cent ) out of the targeted 69.83 lakh families have been trained so far. Due to improper selection of beneficiaries, 93.14 per cent of the candidates sponsored by the Local Self Government Institutions 1 (LSGIs) from socio-economically marginalized sections of the society could not complete the e-vidya course, a higher level computer course envisaged in the second phase of Akshaya. Owing to the low turn-out of beneficiaries in the rollout phase, an amount of Rs 39.56 crore transferred from the LSGIs to the Kerala State IT Mission for the project remained unutilized (ibid). The backend providers of information, i.e., Government departments and agencies, were not disseminating the required information to these e-kendras effectively even after six years of implementation of the pilot project. The project has miserably failed to generate the targeted employment as well as investment. The stakeholder relations are also found to be unwelcoming. The due role expected to be performed by the LSGIs for the proper functioning of the Akshaya project has not really come up. The cooperation from beneficiary departments is far from satisfactory. The entrepreneurs are yet to be entrepreneurial. The citizens trust in the system need to be strengthened. These deficiencies, however, do not reduce the space of the project in the e-governance


Based on differential equation,considering Darcy law and Klinkenberg relationship,unsteady-state flow behavior of nitrogen in core is described and the calculation formula is theoretical derived.Based on the theory,an unsteady-state method of measuring gas permeability of core is given.The measurement method is simple and quick,and having feasibility.


Key Management is a vital procedure for the appropriate performance of any cipher system. Of key management sub-items is the key change policy that arouses a quest about the limitations of time interval elapsed before necessitating the replacement of the secret base key. This paper discusses the problem of the base key validity time for two distinct cipher systems ;namely the straight forward(synchronous) and the cipher feedback(self-synchronous) stream cipher systems. Its result is depicted as a graph aiding to either choose number of bits for some key parameters in system design forgiven validity interval duration or to evaluate an already implemented system. I.Introduction and Problem Definition In cipher systems, secret keys are those variable parameters used to control their performance. The base key is that one that constitutes all portions of secret keys which can, hardly, be changed neither per message nor per transmission session. This is simply because, base key change requires an arduous procedure and dedicated resources imposing to keep the base key valid for certain number of messages (message interval) or for certain time period (time interval). For optimizing key management procedure we have to define a limit for the validity interval of a base key on practical basis other than the validity interval defined by the time of executing an exhaustive search attack for secret base key'. This latter limit is excluded as being irreasonable to be admitted today, since designers of cipher systems were aware enough fqr that type of attacks by increasing the length of base key expressed in bits. Consequently the up to date cipher systems can not be easily cracked by trying all possible keys and such brute force attack entails time amount approaching several years even with very fast trials of one nanosecond per key. In this work, we consider the aspect of message key which is an akin to straight-forward stream cipher systems and the aspect of cover time for cipher feedback systems for the purpose of defining a practical limit for base key retention or replacement. In section 2, we use the message key principle in conjunction to straight-forward cipher system to attain our objective and this section includes deduction of the base key Y.A.Abou Kerisha (Armed Forces ,Signal Corps) M.N.Saleh (Faculty of Engineering ,Ain Shams University) • FIFTH ASAT CONFERENCE 4-6 May 1993, CAIRO CM-2 440 message interval and its practical interpretation. In section 3, we discussed the cryptanalysis principle applied cipher feedback systems and this section includes deduction of base key time interval and its practical application. Finally, conclusions are given. II. Key Validity Time in Straight-Forward Cipher Systems In these systems, a message key is associated with the base key. Such message key is a subset including certain number of bits ranging to about one fourth of the base key length. Message key has the task of randomizing the starting point of the enciphering sequence of the stream cipher key sequence generator. At the start of enciphering each message; a message key is generated usually using a true random bit generator and send to the deciphering side ahead of the enciphered message [1]. The message key is then mixed with the base key, in some way or another, the mixture is used to initialize the enciphering algorithm (the key sequence generator algorithm). II.1. Evaluation of the Validity Time To avoid having two sequences enciphered by the same enciphering sequence, a distinct message key is used for each enciphered message. For a message key with L bits, the pool of message key has a number M of key possibilities given by :


In this paper, we study some non-classical properties of the superposition of photon-added pair coherent state (SPAPCS) such as two-mode sum squeezing and entanglement. The obtained results show that this state has two-mode sum squeezing behavior but the pair coherent state does not. The degree of squeezing of the SPAPCS is enhanced as more and more photons are added to the two modes of the original pair coherent state. Besides, this state is an entangled state and the entanglement degree can be enhanced by adding photons to both modes of the state. When using the SPAPCS as an entangled resource for a coherent state quantum teleportation, it is shown that the quantum teleportation process is successful and the average fidelity of the process can be higher than that of the case where the original pair coherent state is used if the parameters are selected appropriately.


The precise determination of the B{sub s}{sup 0}/B(bar sign){sub s}{sup 0} oscillation frequency provides a powerful constraint on parameters in the CKM matrix. While previous experiments have only had sufficient sensitivity to set limits, the CDF and DO experiments have recently presented independent analyses in which the results are interpreted as the direct observation of B{sub s}{sup 0} oscillations. The recent results from CDF and DO are presented, emphasizing key aspects of the CDF analysis that have significantly enhanced its sensitivity to oscillations in the existing data sample from pp(bar sign) collisions recorded at the Fermilab Tevatron.


This article introduces the investigation results of European heat treatment equipment and commercial heat treatment plants organized by China H.T. Assocition in this year. The aushor considers that the low pressure carburizing and the high pressure gas quenching are the main direction of development for European H. T. technology. Recently the technology has achieved satisfaction already and can meet the requirement of mass production, and is expected to be used first of all in the automobile industry in a wide scope.


IMPLICATIONS
Our case report describes the electrophysiological features associated with the development of a spinal epidural hematoma during surgery of the lumbar spine. It stresses the importance of the evaluation of nonsurgical factors, which can potentially affect intraoperative evoked potentials; in this case, epidural local anesthetic or epidural hematoma.


"Automatic detection and tracking of interesting targets from a sequence of images obtained from a reconnaissance platform is an interesting area of research for defence-related applications. Image registration is the basic step used in target tracking application. The paper briefly reviews some of the image registration algorithms, analyse their performance using a suitable image processing hardware, and selects the most suitable algorithm for a real-time target tracking application using cubic-spline model and spline model Kalman filter for the prediction of an occluded target. The algorithms developed are implemented in a ground-based image exploitation system (GIES) developed at the Aeronautical Development Establishment for unmanned aerial vehicle application, and the results presented for the images obtained during actual flight trial.


PURPOSE Specifi c provider-patient communication styles have been shown to increase the rates of vaccination acceptance among patients. However, whether the chosen communication styles used by PAs differ when discussing mandatory vaccines versus recommended vaccines is not known. This survey explored PAs' opinions, knowledge, attitudes, and beliefs about mandatory vaccines versus recommended but not required vaccines.


Mao Zedong had always attached great importance to socialist democratic politics in the process of constructing socialist modernization.He founded the theory of people's democratic dictatorship,proposed to correctly distinguish two antinomies of different nature,initiated people to be the masters of their own,and established a political strategy for the Communist Party to supervise mutually with other Parties and exist long together.However,he also made some mistakes in this process.Deng Xiaoping succeeded Mao's democratic political ideology and further developed socialist democratic politics.A socialist,modern country with clear and bright politics and people's democracy is being formed.


As the government's public services have been digitized, the necessity of research on the use of e-government services by middle and high-aged people has been raised. Thus, this study aims to verify the mediating effect of digital capacity on the relationship between the family structure and use of e-government services of middle and older aged adults. The study analyzed 1,660 middle and elderly individuals from the 2018 Digital Divide Survey conducted by the National Information Society Agency(NIA) using Baron & Kenny(1986)'s method for mediation. The result is as follows: first, the family structure of the middle and older adults has a significant effect on use of e-government services. Second, the effect of the family structure of middle and older aged people on use of e-government services is partially mediated by digital capacity. The result represents that the elderly living with two or three generations have higher use of e-government services than the elderly living alone and married elderly couple. Also the elderly living with two or three generations have higher digital capacity, resulting in higher use of e-government services. Based on the results, The study suggested that the specific plan for each type of family structure to promote the use of e-government services and a plan to improve the digital capacity of middle and older aged adults.


Introduction : Head and neck sarcomas are rare, malignant and very heterogeneous tumors. The difficulty to manage these sarcomas requires the intervention of a multidisciplinary team to improve the prognosis. The aim of our study is to report our series (epidemiological, histological and progressive characteristics) and evaluate our treatment results. Patients and methods : This is a retrospective study on 42 cases of head and neck sarcomas, assembled at ENT and Maxillofacial Surgery department in the University Hospital of Rabat, for a period of 5 years (2010-2015). All sarcomas were confirmed by histological examination with immunohistochemical study. Results : There were 29 men and 13 women. The average age of our patients was 35.5 years (extremes of age: 13 and 70 years). All patients received a CT scan with MRI scan in 21 cases. A remote extension assessment showed lung metastases in 8 cases. The most frequently found histological type was synovial sarcoma, which was noted in 13 patients (30.9%) followed by osteosarcoma (21.2%). The osteosarcoma treatment was curative in 19 cases, based on surgery with radiotherapy. Total remission was noted in twelve patients. Conclusion : Head and neck sarcomas are rare and very aggressive cancers with poor prognosis. The treatment approach combines surgery and chemoradiation. However, in the absence of adequate and effective treatment protocols, it is necessary to establish a surgical indication in time to ensure excision as complete as possible.


PurposeThe main objective of this research is to exploratorily analyse different factors that influence the decision of the senior population (+50 years) to engage in entrepreneurship activities in a group of Latin American countries. This study considers the motivations for entrepreneurship (opportunity and necessity) and the level of development of the countries.Design/methodology/approachThe authors used data from the Global Entrepreneurship Monitor (GEM) with a sample of 22,139 observations of senior individuals in seven Latin American countries surveyed between 2013 and 2017. The authors also used the Human Development Index to capture the relevance of the level of development. The authors employed a multilevel logistic regression model to test the study hypotheses.FindingsThe study results show that individual factors such as personal income, education and occupation have a significant influence on the probability of entrepreneurship of senior individuals. Related to contextual factors, the level of human development of a country has a negative influence mainly on opportunity-based entrepreneurs.Originality/valueBecause of the rapidly ageing population in Latin America, understanding senior entrepreneurs and their motivations is very relevant not only in terms of theoretical development but also for policy and practical implications, primarily those related to labour markets and social protection.


A device used by lenders to assure payment of debt may endanger lives and be a violation of the Fair Debt Collection Practices Act. This paper examines the use of "kill switches" on vehicles and laws designed to eliminate or curb them.


The mi Ror project investigates the implications of multimedia information retrieval on database design. We assume a modern extensible database system with extensions for feature based search techniques. The multimedia query processor has to bridge the gap between the user's high level information need and the search techniques available in the database. We therefore propose an iterative query process using relevance feedback. The query processor identifies which of the available representations are most promising for answering the query. In addition, it combines evidence from different sources. Our multimedia retrieval model is a generalization of a well-known text retrieval model. We discuss our prototype implementation of this model, based on Bayesian reasoning over a concept space of automatically generated clusters. The experimentation platform uses structural object-orientation to model the data and its meta-data flexibly, without compromising efficiency and scalability. We illustrate our approach with some first experiments with text and music retrieval.


The main objective of this study is to evaluate the viability of using Pyrolized Carbon Black (CBp) derived from waste tires as a reinforcing agent in asphalt mixtures. Commercial Carbon Black (CB) has been previously shown to reduce the rutting resistance, the temperature susceptibility and the cracking propagation potential of asphalt concrete. It was believed that CBp could produce similar benefits, and this laboratory study has shown that such is the case. Different ratios of CBp and CB (5%, 10%, 15% 20% by weight of asphalt) were blended with two grades of asphalt (AC-10 and AC-20) . The Marshall method. the Gyratory Testing Machine, the Dynamic Creep Testing (Confined), the Indirect Tensile Testing and the Resilient Modulus Test were performed The test results were compared to the CB mixtures and the conventional mixtures. The analyses of test results show that the typical performance of CBp modified asphalt mixtures is improved with respect to commercial carbon black and conventional asphalt mixtures. The rutting potential, and the temperature susceptibility can be reduced by the inclusion of CBp in the asphalt mixture. A pyrolized carbon black content of 10% to 15% by weight of asphalt is recommended for the improvement of asphalt concrete.


Print shows two young men leading an ox team pulling a wagon loaded with hay on which a woman and children are riding; also shows farm animals and two female figures possibly representing Demeter, the goddess of the harvest.
Title from item.
Inscribed in lower center from Stephen Duval to James Queen: "Dear Jim - This is the best proof I have taken - you had better keep it. Steve.
Stamped in lower left: From the file of James F. Queen artist, 1824-1889.
Purchase; Marian Carson; 1997; (DLC/PP-1997:105).
Forms part of: Marian S. Carson collection at the Library of Congress.


The research aim of this research is to identify and examine key resources, a conceptual framework drawing on the application of stochastic frontier models in obtaining measures of efficiency that enable a comparison of performance across industries and countries, explaining why, in the same country, some industries achieve superior efficiency performance. The important task is to relate efficiency to a number of factors that are likely to be determinants, and measure the extent to which they contribute to the presence of inefficiency.

More specifically, the first step of this thesis is to review the literature concerned with techniques of efficiency estimation. This will facilitate an understanding of both the theoretical and application part of the research. The second step of this thesis is to highlight the pitfalls of the different relevant models and methodologies. The third and most important goal and contribution of this thesis is to suggest a concrete method to estimate industrial efficiency, avoiding the inherent problems.

This thesis considers a European Union perspective efficiency analysis to increase the information base and derive broader conclusions about European Union productive performance within selected countries. This issue is of particular research relevance because empirical evidence shows that even though European Union industries are widely analyzed with respect to performance, yet little attention has been paid to the estimation of technical efficiency. Within this sample, it is of great importance to examine which determinants are significant, however, it is also important, to examine whether the interactions between technical progress, ICT investment, ICT investment share, R&D stock and economy openness, namely the process of the integration into the world economy, has any implications for technical efficiency. Special emphasis is given to the review of two of the main heterogeneity determining factors, namely innovation investments (as a proxy of knowledge creation) and economy openness (as a proxy of knowledge dissemination).

In particular, this thesis explores whether the interactions between these factors have any implications for efficiency growth, and whether there are any complementarities between them and fostering technical efficiency growth. More specifically, this thesis aims to distinguish between the two main factors which affect total factor productivity, namely technical progress and technical efficiency, as well as what determines the production frontier itself and what determines the inefficiency term (both theoretically and empirically).


This paper investigates the impact of globalisation on the international strategic management process of small to medium sized enterprises (SMEs), within the Australian wine industry (AWI). We identify the particular complexities of international strategy processes for this type of firm. Findings suggest that these complexities stem principally from fundamental variations in strategic outlook between different organisation types, particularly in relation to organisational size, geographic location and the perception that SMEs have of the phenomenon of globalisation. We infer, through 14 case studies with both SMEs and large suppliers within the AWI, that globalisation accentuates the strategic divide between small and large organisations. In particular, the international strategic options available to smaller AWI firms are significantly fewer. SMEs are compelled to adopt almost solely 'business' strategies, as opposed to large firms, which can adopt an array of 'corporate' and 'business' strategies. We also found that AWI SMEs utilise the benefits of location (or 'clustering') namely geographic proximity and that this is different to large organisations, and they face different challenges, stemming from the industry life cycle as a whole. This paper is a work in progress. Material in the paper cannot be used without permission of the author. DIFFERENTIATING THROUGH CLUSTERING: CONTRASTING SMEs WITH LARGE-SIZED FIRMS Dean Weinman & Susan Freeman Working Paper 41/04 August 2004 DIFFERENTIATING THROUGH CLUSTERING: CONTRASTING SMEs WITH LARGE-SIZED FIRMS


The advantages of microorganisms agent and enzyme preparation in treatment of organic industrial wastewater were introduced in this paper, and their application in special organic industrial wastewater, such as, paper making wastewater, printing and dyeing wastewater, chemical industry wastewater, pesticide wastewater and pharmaceutical wastewater were also presented. The developmental tendency of wastewater treatment by microorganism was prompted.


In western countries,comprehensive development theory of rural and urban regions can be divided into three stages: simple coordinative development stage before 1950s,separated development stage from 1960s to 1970s,and fully comprehensive development stage since 1980s.Inspection on the literatures about comprehensive development theory shows that western researchers pay more attention to comparison of developing countries and the regions,attach more importance to integration of space analysis and the social factor,and that few quantitive analysis are committed and confined assumptions exist as well.


We present results of studies e+e− → ηγ cross section in the energy region s < 1.4 GeV performed in SND experiment at VEPP‐2M e+e− collider. The following values for the decay probabilities were obtained Br(φ → ηγ) = (1.341 ± 0.012 ± 0.051) ⋅ 10−2, B(ω → ηγ) = (4.22 ± 0.47 ± 0.17) ⋅ 10−4, and B(ρ → ηγ) = (2.77 ± 0.26 ± 0.16) ⋅ 10−4 for η → 3π0, π0 → γγ decay mode. It was found that cross section of this process may be described by a sum of ρ, ω and φ resonance contributions only.


The current study aims to explain the fundamentals of religious pluralism in Wittgenstein later philosophy and Gadamer philosophical hermeneutics, specifically regarding culture. It, then, proposes the approach more suitable for the Islamic context. Having fulfilled such an objective, pluralism, concerning religious rituals, becomes accepted and cultural and religious interaction is realized without any relativism conclusion. Wittgenstein's pluralism results in pure relativism. That is to say, in order to understand the rules of the language game and life style he mentions, one needs to be placed inside. However, it is a dialectical model that Gadamer philosophical hermeneutics leads to. Dialogue gives opportunity to cultural interaction and convergence, developing the religious culture. The latter is of more proximity to Islamic resources such as the Quran, proposing a religious culture transcending cultural, historical, and social limitations. All in all, the two significant features of Gadamer's which Wittgenstein ignores are first, the interaction of religious pluralism encouraging the development of religious culture and second, reciprocal relation between culture and religion based on hermeneutics circle.


A series of PCNA persimmon originated in China(termed Chinese PCNA persimmon or CPC-NA),distributed in Luotian and Macheng of Hubei province mainly,is a rare germplasm of Diospyros Linn. in the world. There are two important and valuable characteristic for PCNA genetic improvement.One is that CPCNA were evolved independently with PCNA persimmon originated in Japan(termed Japa-nese PCNA persimmon or JPCNA),and the other is that the natural deastringency trait of CPCNA wascontrolled by a single dominant gene locus. Here,on the basis of reviewing the achievement of genetic im-provement and breeding in JPCNA briefly,we focus on the inheritance of natural astringency-loss andearly screening for hybrid population in CPCNA. At last,we propose a comprehensive summary on the ge-netic improvement system for CPCNA based on the recent research results.


The author suggests formulae allowing the loss of speed to be ascertained in a given sea state at a given heading. The loss of speed due to weather of two classes of containerships is established here on a basis of these formulae and this speed is compared with the speed loss obtained from an analysis of the data extracted from the Mate's log. The relationship between wind and waves and their influence on speed is also discussed.


An investigation into how Borassus aethiopum might be prevented from extinction among farmers was carried out in  four communities (Fiaso, Oforikrom, Nyamebekyere and Bayerenkwanta) in the transitional vegetation zone of  Ghana, from  April 2013 to July 2013.  The farmers were randomly selected from the communities. Data were collected from the farmers using questionnaire supplemented with interviews. In addition to the crops grown for food, farmers also obtained food from the wild/non domesticated plants of which Borassus aethiopum was one. Farmers also used Borassus aethiopum, as a timber source, for the production of wine, for roofing and for making fan,  as fire wood and as a medicinal plant. No education had been received on  the plant or even on any other non domesticated plant. All  the farmers agreed that the plant should be preserved, however, only few  (Fiaso – 44%; Oforikrom – 48%; Nyamebekyere – 40%; Bayerenkwanta – 20%) had some ideas on how the plant might  be preserved. The few farmers considered  cultivation (Fiaso – 40%; Oforikrom – 33%; Nyamebekyere – 50%; Bayerenkwanta – 60%)  as a means of preventing the extinction of the plant. Other preservation  methods were;  prevention of bush burning and indiscriminate felling of the tree, and enacting laws on the usage of the plant. It was recommended that all communities with the support of governments should create community forest reserves/parks made up  Borassus aethiopum /non domesticated plant food species, and  also  enact laws to preserve these plants. Keywords : Borassus aethiopum,  extinction, preservation


Henoch Schonlein purpura (HSP) is a small vessel vasculitis leading to deposition of immune IgA complexes. It presents with a tetrad of symptoms, including a purpuric rash occurring on the lower extremities, gastro intestinal involvement, renal involvement and arthritis. HSP is self limited and primarily affects children. The etiology is unknown. Treatment is mainly supportive therapy with analgesics and in severe cases, steroids are used. Here we report a rare case of Henoch Scholein purpura in a postmenopausal woman presenting as acute distal ileitis. cell


A new approach to synthetic voice generation and modification is described. One aspect of the approach is that no attempt is made to parametrize voices, unlike the commonly used Gaussian Mixture Model (GMM) paradigm and the newer eigenvoice techniques. Instead, a straightforward unit selection approach is adopted. A second aspect is that we systematically examine mixing units from different voices in a unit selection context. We present experimental results to show the effect of different voice mixing strategies. The modified voices we produce are high quality but do not have the full range of possibilities achievable using voice conversion. Perceptual evaluations of voice similarity and paired comparison preference judgments of the synthetic voices were used to examine the importance of several features or classes of phones to perceived speaker identity.


Part of a series of short films that attempt to reconstruct the artists recorded experiences of Redacre Wood in Mytholmroyd. This database of records is in the form of photographs ( = light, colour, movement) and texts ( = narratives, memories, fictions). Chance operations control the blending of images over time and the ordering of the lines of text. Each of the films is unique, and yet so similar to all of the others.

Digital video (generative). Stereo. Duration 12:00

Exhibition history:
06.12.2014
Night Beams (Lamplighter Festival)
Fundevogel, Todmorden.


Internet of drones (IoD), where drones act as the Internet of things (IoT) devices, makes IoT networks much more flexible and responsive because of high mobility of drones. Machine learning (ML) techniques can be applied in IoD to facilitate multiple applications such as object tracking and traffic surveillance, where ML data samples are collected and analyzed in the edge servers at the ground base station (BS). However, aggregating all data samples incurs huge wireless network traffic and potential data privacy leakage. Federated learning (FL) is then proposed to address these challenges by performing local training in drones and aggregating model parameters at the BS without sharing raw data samples. The FL performance in IoD networks is greatly affected by limited drone batteries which power FL local training, wireless data transmission, and drones' movements. This paper hence investigates the energy-efficient FL in IoD networks to optimize CPU frequencies of drones' on-board computing units such that total energy consumption of all the drones in the FL process can be minimized, while satisfying the FL training time requirement. We formulate the problem as a non-linear programming problem and then design an algorithm with polynomial time complexity to derive the optimum solution. Extensive simulations are conducted to demonstrate the performance of our proposed algorithm.


Background: Protein kinase compartmentalization through anchoring proteins provides spatiotemporal specificity. Results: Competitive elution combined with cyclic nucleotide affinity enrichment identifies HAP1 as a putative novel PKG anchoring protein (GKAP). Conclusion: Secondary structure predictions, in vitro binding studies, and site-directed mutagenesis define the binding domain and classify HAP1 as a GKAP specifically anchoring PKG Iβ. Significance: The repertoire of PKG anchoring proteins is expanded, enforcing that also PKG signaling is tightly spatiotemporally regulated. Protein-protein interactions are important in providing compartmentalization and specificity in cellular signal transduction. Many studies have hallmarked the well designed compartmentalization of the cAMP-dependent protein kinase (PKA) through its anchoring proteins. Much less data are available on the compartmentalization of its closest homolog, cGMP-dependent protein kinase (PKG), via its own PKG anchoring proteins (GKAPs). For the enrichment, screening, and discovery of (novel) PKA anchoring proteins, a plethora of methodologies is available, including our previously described chemical proteomics approach based on immobilized cAMP or cGMP. Although this method was demonstrated to be effective, each immobilized cyclic nucleotide did not discriminate in the enrichment for either PKA or PKG and their secondary interactors. Hence, with PKG signaling components being less abundant in most tissues, it turned out to be challenging to enrich and identify GKAPs. Here we extend this cAMP-based chemical proteomics approach using competitive concentrations of free cyclic nucleotides to isolate each kinase and its secondary interactors. Using this approach, we identified Huntingtin-associated protein 1 (HAP1) as a putative novel GKAP. Through sequence alignment with known GKAPs and secondary structure prediction analysis, we defined a small sequence domain mediating the interaction with PKG Iβ but not PKG Iα. In vitro binding studies and site-directed mutagenesis further confirmed the specificity and affinity of HAP1 binding to the PKG Iβ N terminus. These data fully support that HAP1 is a GKAP, anchoring specifically to the cGMP-dependent protein kinase isoform Iβ, and provide further evidence that also PKG spatiotemporal signaling is largely controlled by anchoring proteins.


Abstract Several international instruments including CEDAW have recognized every human being to be free from any form of violence including being free from inhuman and degrading treatment. Equality of men and women is also recognized starting from the establishment of UN in 1945 under its charter. UDHR, ICCPR and ICSECR are the major international human right instruments which recognized the application of the rights without discrimination based on sex. CEDAW is an important instrument meant to avoid any forms of discrimination against women including gender based violence against women. The ACHPR and the protocol to the right of women in Africa are also crucial regional instruments in the human right field to ensure the right of women within the region. Moreover, Harmful traditional practices and violence against women are recognized as violation of the human rights of women by the treaty bodies established to ensure implementation of the respected international and regional instruments. Ethiopia, after ratification of several international human right instruments took legislative and other important measures to respect the rights of women in general. However, such measures are remained to be insufficient. Abuses of women rights continued to persist, perpetrators remained unpunished or punished with fines or quiet few years of imprisonment for gross violations of Women's rights. Particularly, the situation of domestic violence including intimate partner violence, as some scholars rightly put it, is beyond the expectation of the 21st century. The constitution of Ethiopia entitled women several rights though it is not still perfect. The revised family code of Ethiopia also recognized several rights which were not included in the civil code of Ethiopia. The criminal code of Ethiopia has also criminalized several harmful traditional practices such as FGM, abduction, and rape. Despite all these legislative measures, violation of the fundamental women's right still continue to exist. The thesis is meant to show the readers the prevalence of violence against women and harmful traditional practices including domestic violence, sexual violence, FGM and early marriage as well as to show gaps on the administrative and legal measures taken by relevant actors to tackle the problems in light of the international human right standards. To fulfill the obligations envisaged under international human right instruments, the study recommends the state and the relevant actors to take legislative and administrative measures to tackle the problem from its grass roots and increase protection for victims of harmful traditional practices and gender based violence. (Less)


It is demonstrated unambiguously that a single methyl group can be responsible for two well resolved minima in the temperature dependence of its proton spin-lattice relaxation time. The analysis of seven infrared absorption bands verifies that these minima are due to (i) hindered threefold reorientation of the methyl group and (ii) transitions of the methyl group between its ground and first excited torsional state. The investigations were made on the isolated methyl group in p-tert-butyltoluene, which was found to have a threefold potential barrier hindering its reorientation of amplitude (4.13+or-0.07)kJ mole-1.


Please cite this paper as: Hirayama F, Koyanagi A, Mori R, Zhang J, Souza J, Gülmezoglu A. Prevalence and risk factors for third‐ and fourth‐degree perineal lacerations during vaginal delivery: a multi‐country study. BJOG 2012;119:340–347.


Jurisdiction — In general — Territorial — Exemptions from — Foreign States — East African Currency Board — The law of England.


Corrosion damage to metal is one of the main factors that reduce the safety of operation of main pipelines. It is known that about 70 % of pipeline failures occur due to metal corrosion. Electrochemical protection in combination with non-metallic coatings is currently the main method to prevent aggressive effects of corrosive media on main pipelines. The use of these methods of protecting pipelines has a number of difficulties that can be associated with the use of several protective coatings of different types and conditions on one oil pipeline; use of cathodic stations of different design and efficiency; Lack of a system to monitor electrochemical protection objects; difficulties arising during operation of anode grounding electrodes and comparison electrodes. Under these conditions, bringing the technical condition of the anti-corrosion protection system of the main oil pipelines to the level corresponding to the modern requirement of industrial safety is an important task that allows improving the safety and reliability of pipeline transport facilities. The article provides an analysis of the operation of cathodic protection units of the Kaltasy-Yazykovo main oil pipeline and the results of calculations on optimizing the modes of the cathode stations.


This article presents current technologies on coastal ocean wave measurements using buoys, pressure sensors, PUVs, etc. and the quality of their data output. Comparisons between different wave measuring techniques with respect to wave energy measurements and Fourier directional coefficients are also presented.


The invention discloses an automatic stable-lifting type clothes drying rack. The automatic stable-lifting type clothes drying rack comprises a lifting rack, a clothes drying rod and an electric lifting mechanism. The electric lifting mechanism comprises two first winding wheels on the left and the right, the first winding wheels are respectively connected with two pull ropes, the other ends of the pull ropes are respectively connected on the left side and the right side of the clothes drying rod, the lifting rack comprises a slide rod, two slide sleeves sleeve the slide rod, two sides of the clothes drying rod are hinged to one ends of two lower connecting rods respectively, the other ends of the lower connecting rods are hinged with the lower sides of the slide sleeves respectively, the left side and the right side of the electric lifting mechanism are respectively hinged to one end of an upper connecting rod, and the other ends of the upper connecting rods are hinged to the upper sides of the slide sleeves respectively. The automatic stable-fliting type clothes drying rack is simple in structure, the pull ropes are identical in lifting speed, balance of stress on the clothes drying rod during lifting is guaranteed, and inclination and shaking are avoided.


Denotational semantics1,2,3,4 provides a formal method of precisely and concisely specifying languages, programming languages as well as other kinds of software such as editors and file systems. But those attributes that make denotational descriptions so effective also lead programmers and software designers to reject the method as too complex. The main goal of this paper is to provide a nontrivial but relatively simple example suitable for presenting the fundamental concepts of denotational semantics, and in the process illustrate the application of sound design principles to denotational definitions to make them accessible to software designers.


This study was carried out to investigate the speciation and distribution of the heavy metals; Fe, Mn, Cu, Zn, Ni, Cd and Pb in the sediments of Lake Burullus, Egypt. The mean metal concentrations of the sediments followed the order of Fe >Mn> Zn > Cu > Ni >Pb> Cd. The evaluated contamination with these metals was revealed moderate to strong ecological risk. According to applying index of the potential ecological risk index (RI), risk assessment code (RAC) and modified risk assessment code (mRAC); the risk levels showed the following order Cd = Pb>Mn> Ni > Zn > Cu > Fe. Considering the metals speciation, high levels were found in the residual fraction for Fe, Cu, Zn and Ni; while were in Fe-Mn hydroxide fraction for Cd and Pb, and in carbonate fraction for Mn. All metals showed enrichment during summer at stations of the southeastern parts of the lake due to the heavy discharge of contaminants from shakhloba, kotichener and Hoksa drains. Therefore, monitoring of contaminants discharge and determination of heavy metal and other pollutants in the water and sediments and its fractionation at Lake Burullus should be introduced for future and management strategies.


Meyer's comments on the study of discrimination in professional basketball1 contain numerous errors, inconsistencies, and impractical suggestions.2 He notes (if 2) the reluctance by some ballplayers to respond to the questionnaire and the receipt of some hostile comments, and argues that this there fore invalidates any information obtained. These hostile remarks, however, were received from only a few players who did not provide the requested salary information. Hence, hostile responses were not part of the sample. Meyer claims (if 3) that salaries reported in newspapers and news magazines are inaccurate and inconsistent. Thus, he rejects data provided either by the players themselves or reported by secondary sources. One wonders how he expects


This study was conducted to estimate the comparative profitability of Aftab Bahumukhi Farm Limited (ABFL) supervised broiler farms and farmers' own managed broiler farms. Data were collected from randomly selected 90 broiler farmers of which 45 were ABFL supervised farmers and 45 were own managed farmers. Descriptive statistical techniques were used to estimate cost and returns of broiler farming. The study revealed that on an average, total cost of raising broiler per batch per 1000 birds was estimated at Tk. 99,429.00 and Tk. 1,06,330.00 for ABFL supervised farms and farmers own managed farms respectively. The respective average variable costs and fixed costs per batch per 1000 birds were calculated at Tk. 96,218.00 and Tk. 1,02,926.00 respectively. These accounted for 96.77 percent and 96.80 percent of total costs respectably for ABFL supervised farms and independently managed farms. The estimated average gross return was Tk. 1,03,334.00 for ABFL supervised farms and Tk. 1,09,961.00 for independent farms respectively. The average gross margins per batch per farm for 1000 birds were at Tk. 7,470.00 and Tk. 7,035.00 for the ABFL supervised farms and for farmers own managed farms respectively and average net returns were estimated at Tk. 4,259.00 for ABFL supervised farms and Tk. 3,631.00 for farmers own managed farms respectively. From the statistical evidence it was found that profit earned by ABFL supervised broiler farms and own managed broiler farms were not significantly different. DOI: http://dx.doi.org/10.3329/pa.v20i1-2.16875 Progress. Agric. 20(1 & 2): 231 – 236, 2009


The article is dedicated to the bilingual (English-speaking) formation of personality in Ukraine on account of its direction to European integration.  Scholars' definitions of linguistic personality are presented and author's own definition of English-speaking personality is represented. Objects and demands to the formation of English-speaking personality are determined.


Abstract The 1 : 1 adduct compounds which are the prevailing vapour species over equimolar mixtures of AlkF and AlF3 (Alk = Li, Na, K, Rb and Cs) in the temperature range 450-750°C have been isolated in argon and nitrogen matrices and examined bv infrared spectroscopy. Seven frequencies which are assigned to matrix isolated alkali tetrafluoroaluminate molecules have been found for all systems investigated. Group theoretical analysis and subsequent normal coordinate computations of the reassigned frequencies confirm a structural model for the AlkAlF4 molecules having the symmetry C2v-However, the results from this analysis cannot be taken as a definite confirmation of a true bidentate structure for these molecules in the vapour phase. The alkali metal-fluorine bond is found to be rather weak, and the Al-F terminal bond is found to be stronger than the Al-F bridge bond. Qualitative relations between matrix as well as vibrational shifts and potential energy distribution are discussed.


Plans for programming a computer model of human motivation, for use in clinical applications, are described. A system based on parallel cooperating goal-processes is assumed, with the will interpreted as the resource allocator between them. Wishes and wants are distinguished on the basis of resources allocated for action. An interpretation of mental effort in terms of computational work is suggested. The generation of actions through planning, decision-making and forming intentions are discussed in relation to 'regnant' goals. The dual nature of motivation manifested in active and reactive aspects of behaviour are emphasised.


Broad-band 40--350 $mu$ measurements are reported for 31 sources observed with a balloon-borne telescope. All but one of the sources have been identified with galactic H ii regions, of which about one-third are optically visible. The objects include W3 (three components), W49, RCW 36, RCW 38, and 24 sources lying along the galactic plane between l/sup II/=327degree and 349degree. Most of these sources have not previously been observed in the far-infrared. A contour map of the W3 region shows an emission arm extending from the main continuum component. (AIP)


Filtering the immense amount of data available electronically over the World Wide Web is an important task of search engines in data mining applications. Users when performing search often formulate hypotheses that they want to find supporting data for. The initial hypothesis reflects their preliminary knowledge of the subject. The final hypotheses at the end of the search reflect what they learned about a given subject and reflect the supporting information they found during search. We propose an evolutionary computation-based method that automatically generates queries and retrieves information to prove or disprove a given hypothesis. In case there is no supporting data, the system evolves another hypothesis for which it can find supporting data. We show preliminary results obtained for hypotheses related to plague where the data used is the Entrez PubMed data set.


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Cash logistics management is an important business activity of banks.However,because of the influence of plan economy in the past,cash logistics management of China nowadays is facing problems such as high costs,low efficiency and high risks.A new cash logistics management mode should be built under the supply chain framework,which consists of three sub-mode including the third party cash logistics management,strategic alliance of cash logistics,and risk management of cash logistics.The idea of constructing a simulation model about the third party cash logistics management is given,and the results show that the core competitiveness of commercial banks can be improved indeed under the condition that the cash logistics services are outsourced to the third party cash logistics organizations.


The advantages of using method Monte Carlo for simulation of radiative transfer in complex turbid random media like biological tissues are well recognized. However, in most practical applications the wave nature of probing optical radiation is ignored, and its propagation is considered in terms of neutral particles, so-called photon packets. Nevertheless, when the interference, polarization or coherent effects of scattering of optical/laser radiation constitute the fundamental principle of a particular optical technique the wave nature of optical radiation must be considered and taken into account. In current report we present the state-of-the art and the development prospects for application of method Monte Carlo to the point of taking into account the wave properties of optical radiation. We also introduce a novel Object-Oriented Programming (OOP) paradigm accelerated by Graphics Processing Unit that provides an opportunity to escalate the performance of standard Monte Carlo simulation up to 100 times.


In two stories in the Sherlock Holmes Canon, Dr. Watson referred to the lighthouse.In "The Man with the Twisted Lip", Watson said, "Folk who were in grief came to my wife like birds to a light-house." In "The Adventure of the Veiled Lodger", Watson threatened to tell "the whole story concerning the politician, the lighthouse, and the trained cormorant."The paper discusses both of those references.Among the points made about the first reference is that it supports a conclusion that, at the date of narration of the story, Dr. and Mrs. Watson were no longer living together.Among the points made about the second reference is that Michael Harrison's claim that the politician being referred to was Winston Churchill is unsupported by the evidence.


ABSTRACT Two different fluorescent block copolymers of poly(lactic acid) (PLA) and polyethylene glycol (PEG) containing fluorescein grafted to the polymer chain were synthesized by Ugi four-component condensation (UFCC). The structure of these PEG–PLA copolymers was confirmed by 1H-NMR and fluorescence spectroscopy. Paclitaxel-loaded fluorescent microspheres (PCT-FMS1 and PCT-FMS2) were prepared from them by the single-emulsion solvent evaporation method. A kinetic study of drug release in vitro using high-performance liquid chromatography showed a prolonged and controlled release of paclitaxel. Anticancer activity of release medium against colorectal cancer cell line (Caco-2) was determined using the cell viability assay. Paclitaxel-loaded microspheres were able to inhibit cancer cell growth and colony formation. The main contribution of this work is to propose a new application for UFCC in the preparation of biomasked fluorescent drug delivery systems able to improve cancer treatment. GRAPHICAL ABSTRACT


Now there are disorderly expansions in Xi'an spatial development. These bring about the problems on bioenvironmental damages, traffic jam, destruction of historic and cultural remains and etc. Appearances of the problem are relative to excessive centripetal aggregation. In order to suit the needs of Xi'an great development in 21st century, space of Xi'an urban development should be opened up; Xi'an metropolitan area should be set up. Dual-axes spatial structure should be adapted in development of Xi'an metropolitan area. On the basis, spatial structures of Xi'an traffic, industries and bio-environment should be set up again.


The study installed basic stages of pathological system generation in patients with type ] diabetes mellitus. At the prepubertal period takes place decrease of antioxidant defense system and hormone regulation activity, except for TTG. At the pubertal period takes place second products alterations of lipid peroxi dation. Increasing ofMDA and decreasing of TTG, T4, PRL occur in adolescent period


Stony desertification in karst rock areas,becomes an geological hazards problem of popular concern.Its harm has even already threatened homeland security,ecological security and sustainable development of social economy.The characteristics and causes of stony desertification calamity of karst subterranean stream basin in Guangxi Mashan and relationship between the above factors and soil erosion were analyzed,and some suggestions and countermeasures for its comprehensive improvement were put forward.


A derivation of the time-dependent Schr\"odinger equation from the time-independent one is considered. Instead of time, the coordinate of an additional degree of freedom, the clock, is introduced into the original time-independent Schr\"odinger equation. It is shown that the standard time-dependent Schr\"odinger equation can be obtained for the semiclassical clock only. For elucidation of the physical meaning of the equation obtained in this way, various types of clocks are discussed. In addition, the corresponding equation for the density matrix and formulas for the mean values of operators are derived.


Working group reports from the four communities represented at the workshop: (1) Archivists, (2) Journal Editors, (3) IT/Big Data, (4) Ordinary Working Linguists. Presented at the first workshop on Developing Standards for Data Citation and Attribution for Reproducible Research in Linguistics, held at the University of Colorado at Boulder from 09/18/15-09/20/15.


Neutron rich nuclei has been studied with a new phenomenological mass formula. Predictions of different mass formulas for the location of the neutron drip line are compared with those from the present calculation. The implications of the new mass formula for r-process nucleosynthesis are discussed. It is found that though the neutron drip line obtained from this formula differs substantially from other formulas, the r-process abundance upto mass 200 are unlikely to be significantly different. The errors inherent in the mass formula are found to play an insignificant role beyond mass A = 80.


Objective To observe the effects of recombinant human endostatin(endostar) on the radio-sensitivity of human pulmonary adenocarcinoma cell line A549.Methods ①A549 cells were incubated with endostar of various concentrations for different durations under normoxia and hypoxia.The IC20 of endostar was determined by MTT assay.②A549 cells were divided into the control group and the endostar group under normoxia and hypoxia.In the endostar group,A549 cells were incubated with endostar for 24 h,and then the two groups underwent high-energy X-ray irradiation with various doses of 0,2,4,6 and 8 Gy.The survival fraction of A549 cells in each group under different conditions was detected by clonogenic assay,and the mean lethal dose(D0),quasi-threshold dose(Dq),extrapolation number(N),survival fraction at irradiation dose of 2 Gy(SF2) and sensitization enhancement ratio(SER) were calculated based on cell survival curves of single-hit multi-target(SHMT) models.③After being incubated for 24 h under normaxia and hypoxia,A549 cells were divided into the control group,radiotherapy only group,endostar group and combination group(endostar combined with radiotherapy).The apoptotic A549 cells in each group were determined with flow cytometry.Results ①Endostatin can inhibit the growth of A549 cells under normoxic and hypoxic culture conditions,and showed time-and dose-dependence,with IC20 of(330.34±4.18) mg/L and(437.23±3.32) mg/L,respectively.②In SHMT models,the D0 and Dq values in the control and endostar groups were(1.36 and 1.30) vs(1.02 and 1.02) under normoxia and(1.70 and 1.39) vs(2.45 and 1.03) under hypoxia,respectively.SER was 1.04 under normoxia and 1.22 under hypoxia in the endostar group.③Under normoxia,the apoptosis rates in the control group,radiotherapy group,endostar group and combination group were(15.91±0.57)%,(42.70±0.37)%,(19.90±0.48)% and(41.52±0.38)%,respectively,and there was no significant difference(F=1.22,P=0.479) between combination and radiotherapy groups.Under hypoxia,the apoptosis rates in the four groups were(16.72±0.67)%,(30.11±0.95)%,(26.71±0.62)% and(36.34±0.71)%,respectively,and the difference between combination group and radiotherapy group was significant(F=3.34,P=0.036).Conclusion Under normoxia,endostar has no radio-sensitizing effects without a significantly increased apoptosis rate.Under hypoxia,endostar can enhance the radio-sensitivity of A549 cells with a significantly increased apoptosis rate.


The development of volleyball in recent years has greatly conditioned the service, one of the most important elements of the game, with significant technical and tactical changes. A methodology based on observations is proposed using models to quantify and assess the risk levels assumed by volleyball players at the moment of the serve, and developing a system category for it that includes the main response levels that affect this element of the game. This methodology has been tested with a sample from Spanish and Italian leagues, and the results obtained show the validity of the proposed formula.


(3) E(z) = e x p ( ^ 2 + bz)fl(l --—) exp(z/av), the c, by and av are real, c^O, a ^ O , |^|—>oo, and ] C a ^ 2 < ° ° I* a previous note [2] we extended the convolution transformation to a certain class of generalized functions in the case where c = 0 in (3). On the other hand, if we substitute the previously neglected factor exp( — cz) in place of E(z) in (2) and normalized by setting c = l, we obtain (4) G(r) = k(r, 1) where k(r, t) = exp(-r/4/)/(47r/), <*> < r < oo, 0 < / < oo. The convolution transformation (1) then becomes the Weierstrass transformation [ l ; Chapter V I I I ] :


The in-plane properties of paperboard have always been of interest to paper scientists. Tensile properties are crucial when the board is fed through converting machines at high speeds. Compressive ...


Two new dioxomorpholines (1 and 2) have been isolated from the sclerotioid ascostromata of Eupenicillium molle (NRRL 13062). Their structures were determined by analysis of NMR data. Mollenine A (1) exhibited moderate cytotoxicity and antibacterial activity, but neither compound displayed significant antiinsectan activity.


Bacterial-chemical leaching of sulfide cobalt-copper-nickel ore from Shanuch deposit (Kamchatka) under different pulp densities (solid : liquid 1 : 5, 1 : 3, 1 : 2) and mesophilic conditions was investigated. The indigenous mesophilic consortium of chemolithotrophic bacteria isolated from the oxidation zone of cobalt-copper-nickel Shanuch deposit and consisted of Acidithiobacillus ferrooxidans, Sulfobacillus sp. was used as a microbial inoculum. The highest amounts of metal extraction were achieved at pulp density 1 : 5 (67.8 % Ni; 28.3 % Cu; 59.2 % Co). The research results showed also that the fraction of chemical leaching increases with rise of pulp density.


Objective The aims were to modify hospital working environment,make technique process simple and reduce risk rate in nursing care. Method The staff training combining the principles five-routine working regulation into nurses' daily practice was carried out.The five-routine working regulation was considered as the evaluation indictor of hospital fundamental nursing.Results The hospital nurses actively conducted five-routine working regulation program.This activities were helpful to enhance staff spirit,improve environment and ensure safe nursing care.In addition,the in-patients expressed more satisfied.Conclusion Five-routine working regulation is one of most effective and simplest methods to improve nursing management quality.


Based on the annual average temperature,precipitation,average wind speed,the number of gale days and dust storm days from 1959 to 2011 at 12 meteorological stations of the Black Gobi desert region,the climatic change characteristics were analyzed by a climatic trend method and it was compared with that in the desertification region. The results indicate that the annual mean temperature increases and its rates are 0. 34 ℃ and 0. 25 ℃ per decade in the Black Gobi desert and desertification regions,so is the annual precipitation and its rates are 1. 33 mm and 1. 66 mm per decade respectively. The annual mean surface wind speed decreases in the Black Gobi desert region with 0. 10 m·s-1per decade and in the desertification region with 0. 14 m·s-1per decade,so is the number of gale days in Black Gobi desert region with 1. 83 days per decade and in the desertification region with 3. 44 days per decade. The number of dust storm days decreases in Black Gobi desert region with 1. 83 days per decade and in the desertification region with 1. 77 days per decade,respectively. There is only one abrupt change point for most climatic factors except annual precipitation according to a Mann-Kendall test method. The spatial distributions of various climatic factors are different.


Articles et rapports selectionnes Babbitt CW, Kahhat R, Williams E, Babbitt GA. Evolution of product lifespan and implications for environmental assessment and management : A case study of personal computers in higher education. Environmental Science and Technology 2009 ;43(13):5106-5112. Choi B-, Shin H-, Lee S-, Hur T. Life cycle assessment of a personal computer and its effective recycling rate. International Journal of Life Cycle Assessment 2006 ;11(2):122-128. Duan H, Eugster M, (...)


This book is intended to help you to do practical physics at college or university: its aim is to make the laboratory work more useful and profitable. We may start by asking what is the object of laboratory work in a university physics course. There are several possible objects. Laboratory work may serve (a) to demonstrate theoretical ideas in physics, (b) to provide a familiarity with apparatus , (c) to provide a training in how to do experiments . Let us consider each of these in turn. Seeing something demonstrated in practice is often a great help in understanding it. For example, interference in light is not an intuitive concept. The idea that two beams of light can cancel each other and give darkness takes a little swallowing, and most people find it helpful to be given a visual demonstration. A demonstration is useful for another reason – it gives an idea of orders of magnitude. The interference fringes are in general close together, which indicates that the wavelength of light is small compared with everyday objects. But the demonstration is no substitute for a proper explanation, which goes into the details of geometry and phase relations. So the first object, the demonstration of theoretical ideas, has a definite but limited usefulness.


The various heat treatments of Nd 15.5 Fe 76 B 8.5 magnets were conducted. To botain the optimum intrinsic coercivity, iHc, it is only needed to do post-sintering annealing at 650°C for 0.5-1 hour followed by oil quench, regardless of the other heat-treatment details. The same optimum iHc value can be obtained by five different heat-treatment patterns. More than two steps heat-treatment improves little in intrinsic coercivity. The intrinsic coercivity is composition dependent and maximum iHc value increases with the increasing of Nd-content. The intrinsic coercivity drops to some lower value when the magnet was slowly cooled to room temperature after heat-treatment instead of rapid cooling. The reduction of coercivity is dependent upon the comosition and can be recovered by redoing low temperature heat-treatment followed by rapid cooling.


Introduction: Atrial arrhythmias are commonly observed in individuals with systemic lupus erythematosus (SLE), a chronic autoimmune disorder characterized by multi-systemic inflammation. The mechanisms linking these conditions remain to be elucidated. In this study, we conduct in silico experiments to explore the potential association between atrial arrhythmias in SLE patients and the combined impact of structural and electrical remodeling from chronic inflammation. Methods: Structural remodeling was modeled as interstitial fibrosis, and electrical remodeling was attributed to chronic inflammation observed in SLE patients. Eikonal-based simulations were employed to simulate wavefront propagation in a biatrial tetrahedral mesh. Results: Our results suggest that electrical remodeling related to SLE can modify the depolarization pattern and promote the emergence of reentry patterns, potentially initiating arrhythmias. We found that a combination of fibrosis (10% or 40%) and mild inflammation was insufficient to induce arrhythmias. In contrast, a combination of fibrosis (10% or 40%) and severe inflammation could produce non-sustained arrhythmias exhibiting repetitive patterns. Conclusion: Our findings offer insights into the mechanisms responsible for developing atrial arrhythmias in SLE patients and propose that inflammation-driven structural and electrical remodeling may contribute to this condition. This study serves as a starting point for further examination of the complex relationship between SLE, chronic inflammation, and atrial arrhythmias. More-over, thanks to in silico experiments, understanding inflammation's


The way of diagnostics of severity of course of ulcerous colitis has been proposed: studying biochemical structure of cystic bile and defi ning lithogenicity indexes it is possible to diagnose the systems of involvement of biliary system and to judge of the course of ulcerous colitis according to the manifestation of this system. Th e way is noninvasive and is executed in severe course of the disease.


The invention provides a hyperspectral remote sensing image end member extraction method on the basis of a revised extended morphological operator, which is characterized in that an original image is filtered by the opening-and-closing operation and the closing-and-opening operation which are defined by the revised extended morphological operator so as to fulfill the aim of combining spectral information with space information to carry out end member extraction. The method mainly aims to solve the problem of limitation in the extended morphological operator; the revise is carried out by leading in a reference vector; for the provided revised extended morphological operator, the alternately replacing phenomenon is eliminated; the correct replacing direction is ensured; and a separating effect of pure pixels and mixed pixels is reinforced. An experimental result shows that the condition that the method provided by the invention can optimize the end element extraction effect is proved onthe aspects of the spectral curve similarity and a corresponding ground feature distribution map and the like; and the method has a moderate calculated amount and lays a foundation for application ofsubsequent analysis and classification of hyperspectral remote sensing image mixed end members and the like.


We report production of nanostructured magnetic carbon foam by a high-repetition-rate, high-power laser ablation of glassy carbon in Ar atmosphere. A combination of characterization techniques revealed that the system contains both sp2 and sp3 bonded carbon atoms. The material is a form of carbon containing graphite-like sheets with hyperbolic curvature, as proposed for "schwarzite." The foam exhibits ferromagnetic-like behavior up to 90 K, with a narrow hysteresis curve and a high saturation magnetization. Such magnetic properties are very unusual for a carbon allotrope. Detailed analysis excludes impurities as the origin of the magnetic signal. We postulate that localized unpaired spins occur because of topological and bonding defects associated with the sheet curvature, and that these spins are stabilized due to the steric protection offered by the convoluted sheets.


In the recent years, a term keeps coming in the sph re of IT. This new concept called cloud computing is probably the most noteworthy evolution since the ar riv l of the web. Many business leaders have decide d to invest in this architecture in order to gain in ter ms of saving on material and human resources. Cloud computing can outsource the IT hub of a company, th erefore it can focus on its own business. Cloud computing is not only full of benefits. Indeed, it is still subject to several threats related to secu rity which is now must be implemented at a large scale so the tra nsi ion to the cloud should be attended by some adaptations to export all the known security arsena l. Besides, billing within cloud services does not obey until now to precise and deterministic rules and ma ny companies are crying foul when they are charged with an extortionate price. Cloud computing has cer tainly turned upside down the practices of business and IT professionals need to review their careers. Howe ver, some still do not dare to step into this archi tecture and they claim that more research effort must be do ne in order to fill the gaps in the cloud. This pap er targets to afford a best description of cloud compu ting features and explore guidelines for research a nd high-tech tendencies in order to use and implement cloud infrastructure networks. The chief concepts o f cloud computer billing and security threats will be also exposed.


Yeast with better chromium-absorption has been selected as the test strain. According to the experiments on the chromium-tolerance of yeast, Adding chromium content on the molasses medium was decided. Application of chromium-rich yeast on the diabetes was discussed. At the end of fermentation, the chromium of the yeast is 738.8mg/kg, protein over 48.74% (w/w). The yield of chromium-rich yeast is 3.0% (w/v).


Based on the development status of under-forest economy, under-forest economy layout was analyzed from spatial structure and industrial structure, industrial planning of under-forest economic development in Hebei was pointed out.


The appearance of pre-earthquake thermal anomalies before the great megathrust earthquake in Banda-Aceh, Sumatra on 26 December 2004 has been detected by thermal AVHRR sensor in NOAA series of satellites. The anomalies appeared five days prior to the major shock of magnitude (Mw) 9.0 and reached to a maximum on 25 December 2004, just one day before the main event. The rise in temperature was about 4-6?C. The rise in temperature subsided along with the earthquake. Seawater turbidity induced by the underwater rupture and the violent tsunami was evident through NOAA-AVHRR and Terra-MODIS data.


AIMS AND METHOD

Clinical governance implies a need to engage in a demonstrable form of clinical audit. We decided to pilot a pre-post-therapy questionnaire study, involving both therapists and patients, with the aim of assessing its feasibility as a routine measure of outcome in our service.

Questionnaires were chosen to reflect both the symptom profile Clinical Outcomes in Routine Evaluation (CORE) and the general level of functioning Global Assessment of Functioning Scale (GAF). The patients were also questioned about their satisfaction with the therapy.

RESULTS

Of 53 eligible patient-therapist pairs, 26 patients and 19 therapists responded pre-treatment (overall 51% response rate). The mean (s.d.) CORE score per item was 1.93 (0.78), whereas the GAF score was 55 (15.2), somewhat belying the idea that psychotherapists only treat the 'worried well'. The post-therapy response rate was poorer, rendering statistical analysis of change difficult to perform. The trend, however, was towards an improvement in both symptoms and level of functioning over the course of therapy.

CLINICAL IMPLICATIONS

Our patient group presents with a considerable degree of impairment. Although the response rates in this pilot study were poor, the data trend suggests that patients do benefit from the treatment offered. The aims of the study were met in that implementation of a clinical audit process within our department is feasible and the data are obtainable. The main interest, however, lies in what we learned from the process. We offer a dynamic and practical assessment of the impediments encountered, with implications for how these might be confronted.


The aim is to study the peculiarities of technical and tactical actions of volleyball players of various playing roles of the VK "Murov" team. Material and Methods: The study involved 14 players of various playing roles, playing in the women's volleyball team "Murov" (Azerbaijan). All volleyball players have a high level of fitness and have participated in competitions of various levels. The age range of female volleyball players ranges from 18 years old (libero) to 28 years old (binder). The most experienced in the team are the tie players (26 years old) and the least the libero (19 years old). Study duration: December 2019 February 2020. In the course of the study, the following methods were used: analysis of video recordings of the games of the women's volleyball team "Murov", which were recorded during the Azerbaijan championship competitions of the 2019-2020 season; methods for assessing technical and tactical actions during competitive activity; methods of mathematical statistics. Results. It has been experimentally proved that the level of technical and tactical readiness of high-class volleyball players significantly differs depending on the playing role. The largest number of attacking strikes falls on the diagonal players (20-25 strikes per game), and the efficiency of their execution is better for the central blockers (60-75%). Identical data were obtained when comparing the quantity and quality of blocking actions. The center blockers make 17 blocks on average, and the diagonal ones make 15 blocks. A significant advantage in receiving the ball is observed in the libero (from 37 to 40 receptions per game). The effectiveness and number of feeds depends on the complexity of their implementation. The largest total number of TTDs (about 78 actions) and the number of transfers from above (about 50 transfers) falls on the main conductor of the team  of the connecting player. Conclusions: the role of universal training of female volleyball players is more and more important, and the determination of the features of competitive activity and the development of the necessary arsenal of technical and tactical actions of players of all playing roles is the leading direction in modern volleyball. However, the question of improving the training system in volleyball and the problem of early selection of female volleyball players, as well as the universalization of their TTD to perform the most useful functions during the game, remains unresolved. All the above is a prospect for further research.


As to its special style,advertising English has a quite different textual mechanism from the other texts.Based on Halliday's cohesion theory,this article tries to give a detailed analysis of the cohesive devices and the characteristics of the advertising English from the aspects of grammatical cohesion and lexical cohesion.


Should a …rm favor a weaker or stronger employee in a contest? Despite a widespread emphasis on rewarding the best employees, managers continue to tolerate and even favor poor performers. Contest theory reveals that evenly matched contests are the most intense, which implies that a contest designer can maximize each player's eort by arti…cially boost- ing the underdog's chances. We apply this type of "handicapping"to a two-period repeated contest between employees, in which the only information available about their abilities is their performance in the …rst-period. In this setting, employees are strategic and forward looking, such that they fully anticipate the potential impact of the …rst-period contest result on the second period contest, and thus adjust their behaviors accordingly. The manager also incorporates these strategic behaviors of employees when determining an optimal handicap- ping policy. If employees'abilities are su¢ ciently dierent, favoring the …rst-period loser in the second period increases total eort over both periods. However, if abilities are suf- …ciently similar, we …nd the opposite result occurs: total eort increases most in response to a "reverse handicapping"strategy that favors the …rst-period winner. We also show that reverse handicapping maximizes eort even with perfect information.


There are two ways to learn radial basis function (RBF) networks: one-stage and two-stage learnings. Recently a very powerful one-stage learning method called RBF-SSF has been proposed, which can stably find a series of excellent solutions, making good use of singular regions, and can monotonically decrease training error along with the increase of hidden units. RBF-SSF was built by applying the SSF (singularity stairs following) paradigm to RBF networks; the SSF paradigm was originally and successfully proposed for multilayer perceptrons. Although RBF-SSF has the strong capability to find excellent solutions, it required a lot of time mainly because it computes the Hessian. This paper proposes a faster version of RBF-SSF called RBF-SSF(pH) by introducing partial calculation of the Hessian. The experiments using two datasets showed RBF-SSF(pH) ran as fast as usual one-stage learning methods while keeping the excellent solution quality.


The research is devoted to the identification of ontological basics of reflection on the ground of the analysis of philosophical ideas by Thales, Leucippus, Democritus, Epicurus and Aristotle. It is shown that the reflections of these antique philosophers concerning thinking and cognition belong to the materialistic conception of scientific knowledge whose basic principle is the principle of reflection. The problem of reflection begins with a known aphorism by Thales "learn yourself", and it is continued in Leucippus and Democritus's reflections, according to which the whirlwind of the atoms submitting to mechanical laws is the reason of any movement and physical processes. In Epicurus's philosophy the structure of the "external" world and the structure of soul are considered. From the point of view of Aristotle, we think of a subject of thought as about a form in images by means of imagination and then we draw up judgments. Thereby, the subject of thought sets the conceiving part of soul in motion, causing its high-quality changes. As a result of the analysis of works of the antique philosophers representing materialistic tradition, the author comes to the conclusion that originally the problem of reflection was connected with the self-cognition and it was solved within the materialistic conception.


Toasting wood to be used in barrels for aging wine and brandy produces a great number of volatile and odiferous compounds. Some of these have a "toasty caramel" aroma. Analysis by high-performance gas chromatography of toasted oak extracts, combined with olfactory detection, enabled various chromatographic peaks with these specific aromas to be isolated. These same odors were simultaneously studied by heating glucose both with and without proline. Aromatic compounds of interest were identified thanks to a combination of gas chromatography and both mass and infrared spectrometry. In addition to already-known substances such as 2-hydroxy-3-methyl-2-cyclopenten-1-one (cyclotene) (1) and 3-hydroxy-2-methyl-4H-pyran-4-one (maltol) (2), we identified, for the first time, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP) (3), 4-hydroxy-2,5-dimethyl-3(2H)-furan-3-one (furaneol) (4), and 2,3-dihydro-5-hydroxy-6-methyl-4H-pyran-4-one (dihydromaltol) (5) as compounds which actively contribute to the "toasty c...


Seafood processing byproducts may account for up to 80% of the weight of the harvest and, depending on the species involved, include a variety of constituents with potential for use as nutraceuticals and bioactives. Nutraceuticals, defined as ingredients or extracts with clinically proven health promoting activity, including disease prevention and treatment, may be consumed in the medicinal form, as supplements or as functional food ingredients. Thus, a variety of seafood processing byproducts may render benefits above their nutritional value. As an example, highly unsaturated long-chain omega-3 fatty acids, derived from the liver of white lean fish, flesh of fatty fish, and blubber of marine mammals, exhibit important biological activities. They also serve as the building block fatty acids in the brain, retina, and other organs with electrical activity. Hence, inclusion of oils containing docosahexaenoic acid (DHA) in the diet of pregnant and lactating women as well as infants is encouraged. In addition, chitinous materials, carotenoids, and biopeptides, arising from proteins, may be recovered from processing byproducts of crustaceans, including shrimp, crab, and lobster. The health benefits of chitosan, chitosan oligomers, and glucosamine are related to the multifunctional role of these ingredients, including immunomodulatory activity. Meanwhile, antioxidative peptides with up to 16 amino acids in chain length have been isolated from skin of pollock and their use as nutraceuticals may prove beneficial. Hence, byproduct processed from seafoods may possess multifunctional roles and could serve as important value-added nutraceuticals and functional food ingredients. 248 Shahidi — Nutraceuticals and Bioactives Advances in Seafood Byproducts 249


With the introduction of symbolic manipulators to the teaching of traditional university courses we are forced to ask questions about what we are trying to achieve and whether these innovations do, in fact, improve our teaching and the learning of our students. We discover that there is, indeed, an inevitable trade-off for the student between acquiring new insights and losing traditional skills. The paper included the results of surveys conducted over large first year classes as part of on-going research in this field.


On a separate note, it is a shame the book contains neither bibliography nor indication of where rare documents were located. Although ministerial reports and legal codes are fairly easy to find, many of the important but more ephemeral pieces Cruz cites doubtless hide on the shelves of the various private and public archives he consulted. Nicaraguan history remains much in its infancy and Cruz could certainly have helped guide other scholars to these materials. Nonetheless, the book lays a foundation for rethinking Nicaraguan political history and will serve as a key text /or Central American historians for some time to come.


Context. Stars are born deeply embedded in molecular clouds. In the earliest embedded phases, protostars emit the bulk of their radiation in the far-infrared wavelength range, where Herschel is perfectly suited to probe at high angular resolution and dynamic range. In the high-mass regime, the birthplaces of protostars are thought to be in the high-density structures known as infrared-dark clouds (IRDCs). While massive IRDCs are believed to have the right conditions to give rise to massive stars and clusters, the evolutionary sequence of this process is not well-characterized.Aims. As part of the Earliest Phases of Star formation (EPoS) Herschel guaranteed time key program, we isolate the embedded structures within IRDCs and other cold, massive molecular clouds. We present the full sample of 45 high-mass regions which were mapped at PACS 70, 100, and 160 μ m and SPIRE 250, 350, and 500 μ m. In the present paper, we characterize a population of cores which appear in the PACS bands and place them into context with their host molecular cloud and investigate their evolutionary stage.Methods. We construct spectral energy distributions (SEDs) of 496 cores which appear in all PACS bands, 34% of which lack counterparts at 24 μ m. From single-temperature modified blackbody fits of the SEDs, we derive the temperature, luminosity, and mass of each core. These properties predominantly reflect the conditions in the cold, outer regions. Taking into account optical depth effects and performing simple radiative transfer models, we explore the origin of emission at PACS wavelengths.Results. The core population has a median temperature of 20 K and has masses and luminosities that span four to five orders of magnitude. Cores with a counterpart at 24 μ m are warmer and bluer on average than cores without a 24 μ m counterpart. We conclude that cores bright at 24 μ m are on average more advanced in their evolution, where a central protostar(s) have heated the outer bulk of the core, than 24 μ m-dark cores. The 24 μ m emission itself can arise in instances where our line of sight aligns with an exposed part of the warm inner core. About 10% of the total cloud mass is found in a given cloud's core population. We uncover over 300 further candidate cores which are dark until 100 μ m. These are possibly starless objects, and further observations will help us determine the nature of these very cold cores.


Objective To study clinical value of the joint measurement of serum concentrations of type Ⅳ collagen (ⅣC) and laminin (LN) in patients with diabetic nephropathy (DN) by radioimmunoassay (RIA). Methods Serum concentrations of ⅣC,LN were measured by RIA in 35 diabetic patients with normalbuminuria (group A),28 cases of microalbuminuria (group B),15 cases of macroalbuminuria (group C) and 30 normal subjects as control. Results The serum concentrations of ⅣC,LN in total 78 diabetic patients [(97.6±19.2),(132.4±31.5) μg/L] were higher than that of the controls [(77.4±8.2),(101.5±17.6) μg/L,P 0.05],especially in group B and C,it was remarkablely higher compared with the controls ( P 0.05,P 0.01). There was significant positive correlation of serum ⅣC,LN to diabetic duration and the levels of blood urea nitrogen (BUN),creatinine (Cr),urinary albumin excretion rate (UAER). Conclusions The results suggest that the joint measurement of serum levels of ⅣC,LN and UAER in DN patients might better evaluate the development process of DN,and be of help for early diagnosis and treatment of DN. Serum levels of ⅣC,LN and UAER in DN patients may become the reliable clinical markers for assessing the severity and predicting the prognosis of DN.


The phenomenon of ultrasonic double refraction and methods of observing it with pulsed echo methods are described in some detail. Two causes of ultrasonic double refraction are described. Double refraction effects were observed in three germanium single crystals. The main cause of the effects reported here seems to be a small angular difference between the propagation direction and a principal axis of the crystal.


The task of higher vocational school is to cultivate the talents for production,construction,service and management.Only by individuality development can this mission for higher vocational school be successfully accomplished.The characters of individuality lie in cultural individuality,talented superiority,professional characters,regional characteristics.Individuality development of higher vocational school is essential prerequisite for fulfillment of public service.


Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder characterized by seemingly unprovoked recurrent episodes of fever and serosal, synovial, or cutaneous inflammation. FMF is caused by recessively inherited mutations in MEFV, which encodes pyrin, and most of the mutations are present in the C‐terminal end of the protein encoding B30.2 domain. The FMF carrier frequencies are extremely high in several eastern Mediterranean populations. Pyrin is expressed in granulocytes, monocytes, dendritic cells, and synovial fibroblasts. Pyrin regulates caspase‐1 activation and consequently interleukin‐1β production through the interactions of its N‐terminal PYRIN domain and C‐terminal B30.2 domain with an adaptor protein, apoptosis‐associated speck‐like protein with a caspase‐recruitment domain (ASC) and caspase‐1 respectively. Pyrin is cleaved by caspase‐1 and the cleaved N‐terminal fragment translocates to nucleus and enhances ASC‐independent nuclear factor (NF)‐κB activation through interactions with p65 NF‐κB and IκB‐α. In addition to the regulatory role of pyrin for caspase‐1, the cleavage of pyrin provides an important clue not only in understanding the molecular pathogenesis of FMF but also in developing new therapeutic targets for FMF.


The Internet of Things (IoT), as expected infrastructure for envisioned concept of Smart City, brings new possibilities for the city management. IoT vision introduces promising and economical solutions for massive data collection and its analysis which can be applied in many domains and so make them operating more efficiently. In this paper, we are discussing one of the most challenging issues - municipal waste-collection within the Smart City. To optimize the logistic procedure of waste collection, we use own genetic algorithm implementation. The presented solution provides calculation of more efficient garbage-truck routes. As an output, we provide a set of simulations focused on mentioned area. All our algorithms are implemented within the integrated simulation framework which is developed as an open source solution with respect to future modifications.


Background: The latest report by the world health organization and international agency for research on cancer told that the incidence and mortality of breast cancer is the most among female cancer patients.
Methods: This is descriptive study which uses medical record of 50 samples patients in Dharma Yadnya general hospital. This study include patients  at least 25 years old who presented to the Dharma Yadnya general hospital between January 2019 to March 2023 which get breast ultrasound examination and pathology examination, benign or malignant mass.
Results: In ultrasound findings, there are 43 (86%) people with benign cancer, 7 (14%) people with malignant cancer, 43 (86%) people with hipoechoic density and solid lession, 7 (14%) people with isoechoic density and cystic lession, 43 (86%) people with regular margin, 7 (14%) people with irregular margin, 43 (86%) people without lymph nodes axillary, 7 (14%) people with lymph nodes axillary, and by Doppler there are 43 (86%) people without neovascularitation inside lession and 7 (14%) people with neovascularitation inside lession. There are statistically significant relationship (p<0.05) between diagnosis (benign and malignant) with age of patients, density, margin, existence of lymph nodes axillary, and neovascularitation inside the lession by doppler.
Conclusions: Breast sonography is the modality of choice for further investigation of palpable breast findings that are not clearly benign and mammographic screen-detected abnormalities.