Surface Modification of Na2Ti3O7 Nanofibre Arrays by N-doped Graphene Quantum Dots as Advanced Anodes for Sodium-ion Batteries with Ultra-stable and High-rate Capability Dezhi Kong , Ye Wang †, , Shaozhuan Huang , Yew Von Lim , Jun Zhang , Linfeng Sun , Bo Liu , Tupei Chen , Pablo Valdivia y Alvarado, and Hui Ying Yang †* † Pillar of Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore 487372, Singapore. ‡ Key Laboratory of Material Physics of Ministry of Education, School of Physics and Engineering, Zhengzhou University, Zhengzhou 450052, China § School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore.


The reason of propane oxidized to produce acrylic acid multi-component catalyst losing activity was studied,and the way for the catalyst regeneration was discussed.As the results showed,the main reason for multi-component catalyst using propane oxidization to produce acrylic acid to deactivate was the loss of Te.Further experiment proved that when the deactivated catalyst was impregnated by Mo,V,Te,Nb,respectively,the yield of acrylic acid increased from 1.4% to 4.2%(still far lower than the fresh catalyst) when the catalyst was impregnated by Te.The yield of acrylic acid using the deactivated catalyst impregnated by Mo,V,Nb did not change.


Publications, manuscripts and presentations, which include studies of fluid and melt inclusions, reveal a wide variety of units and symbols that are not conform with the SI (international system of units). This may cause confusion if these studies are communicated towards the chemical, physical, and mathematical society. Moreover, even within the community of fluid inclusion researchers quantities, symbols and units may be misunderstood. Recently, Diamond (2003) presented a glossary with terms and quantities of importance for fluid inclusion studies, and Kerkhof & Thiery (2001) introduced a variety of quantities to characterize the behaviour (i.e. a series of phase change) of carbonic fluid inclusions during heating in microthermometrical experiments. These recommendations are still absent in many publications. Several modifications have to be applied to these considerations to make them SI conform, which are presented in this study. The main objective of this study is to stimulate the awareness of fluid inclusion researchers of the existence of an internationally accepted code to present quantities in scientific papers. The international system of units (published by the Bureau International des Poids et Mesures, 2006) is the main tool for worldwide unification of measurements, and contains fundamental standards and scales for the measurements of the principal physical quantities. The IUPAC (the 'greenbook', 2 edition, 1998) has adopted the same objectives as the BIPM to improve the international exchange of scientific information and describes a large variety of coherent derived quantities from SI. The coherent derived quantities are mainly used in fluid inclusion research. They provide clear rules about the use of units and symbols, and recommendations about style in geological sciences.


Objective To analyze the clinical use of human albumin in our hospital from January to June 2013,and evaluate the rationality of its application. Methods Retrospective reviewing the use of human albumin in clinical departments from January to June 2013 and referencing the directions for use of human albumin,to evaluate the clinical application of human albumin. Results There were 228 inpatients used human albumin,involving 23 clinical departments. These patients were mainly critically ill patients and tumor,liver cirrhosis and nephropathy induced oedema or ascites were most. 75% of the applications were consistent with indications in directions. Conclusion The application of human albumin still existed some misunderstandings in our hospital,and suggested clinical departments to further study guide drug directions and the application of related drugs,strictly grasp the indications,strengthen the safety management of blood preparation.


The present invention provides an apparatus and method for reducing the intraocular pressure noninvasively. In particular, some non-invasive intraocular pressure device of the present invention comprises a vibrator having a proximal end and a distal probe. Typically, the tip probe of the transducer, without causing any significant damage to tissue includes a substantially non-abrasive material configured to contact with the ocular surface, the ocular surface of the limbal region It has a shape that matches the. The apparatus also includes a vibrating mechanism, operable at the proximal end of the vibration tip as the vibrating tip is moved in the axial direction without damaging the eye cell when the vibrating mechanism is operating is connected to, also comprises vibrating mechanism. Intraocular pressure device of the present invention, it is possible to convey a mechanical force to tissue proximate to the limbal tissue noninvasively. .FIELD 4


Digital Transformations (DT) play an increasingly important role in academia and business, yet their significant Environmental Footprint (EF) is often overlooked, sidelining their potential for Environmental Sustainability (ES). This paper bridges this gap by integrating ES into the discourse of DT, proposing Green Enterprise Architecture (GREAN) as a method for sustainable transformation. Utilizing a Design Science Research approach, we developed an artefact outlining a comprehensive strategy for embedding ES in DT across various layers of an organization. The tool's need was validated via a systematic literature review (SLR), highlighting the significant research gap in Green Enterprise Architecture. The artefact provides concrete Courses of Action (CoAs) for incorporating ES into the organizational strategy, business, data, application, and technology layers and proposes relevant capabilities to address this. The paper further presents an ES-aware business capability modelling, an innovative business modelling approach that integrates environmental sustainability principles by using (in a novel way) the presentation and analysis methods that capability mapping offers. The proposed artefact serves as a starting point for environmentally sustainable DTs. Future research directions include in-depth exploration of each enterprise layer for ES, real-world validation of our proposed tools and concepts, and the expansion of these into a full framework.


In 1975, Suzuki proved that prime decompositions of connected surfaces in S 3 are unique up to stable equivalence of the factors. This paper extends his result to a large class of 3-manifolds, and demonstrates that this result does not apply to all 3-manifolds. It also answers a question he raised by showing that it is possible for inequivalent surfaces in S 3 of the same genus to be stably equivalent. The techniques used involve the notion of Heegaard splittings of 3-manifold triads


The COVID-19 pandemic has upended the basic premises of the economic system as we know it If this pandemic successfully disrupted our ordinary days under capitalism, it should also upend how we imagine the role of our cities As cities around the world plan to recover from this pandemic, there will be a rise in value-laden questions around what kind of collective values communities intend to pursue A post-disaster context often presents an occasion to ask ourselves what we truly value, what we are willing to preserve and what we are willing to forgo In Christchurch, in the aftermath of the devastating earthquake in 2011, citizens were given a chance to discuss what buildings and city infrastructure they considered to be essential and valuable enough to be rebuilt and restored (Gjerde, 2017) The post-COVID-19 condition may offer a similar moment of reflection Here are a few embryonic ideas on how cities may harness this moment to instil their visions towards more equitable, sustainable and resilient urban futures


The complex optical conductivity tensor is calculated for the Co j Pt multilayer systems by applying a contour integration technique within the framework of the spin-polarized relativistic screened Korringa–Kohn–Rostoker method. It is shown that the optical conductivity of the Co j Pt multilayer systems is dominated by contributions arising from the Pt cap and/or substrate layers. r 2002 Elsevier Science B.V. All rights reserved.


Tracer method was used to visualize longitudinal eddies near the edge of a flood plain in an open channel flow. Neutral particle tracers were illuminated by a laser light sheet which was obtained from a 5mW He-Ne gas laser. Set the laser light sheet on a cross section, a vertical section or a horizontal section, pass lines of neutral tracers were observed by a 35 mm still camera or a video camera. Many attractive pictures were taken by a moving camera or a fixed one. Based on these pictures, the three dimensional model of longitudinal eddies near the edge is illustrated.


e18540Background: In spite of the fact G-CSF has been used post stem cell transplant (SCT) to accelerate neutrophil engraftment its use post allogeneic SCT remains controversial. ASCO does not reco...


Purpose
Autism spectrum disorder (ASD) is a group of complex neurodevelopmental disorders with uncertain etiology. Evidence shows that genetic testing can explain about 20% of cases. This study aims to assess the level of awareness and perception of medical genetic services among Malaysian parents with ASD children.

Design/methodology/approach
A cross-sectional survey using an interviewer-administered questionnaire was done among 111 parents of children with ASD from August 2017 to September 2019 in two clinics in Malaysia.

Findings
A majority of children with ASD (80.20%) were male and diagnosed at the age of 3–4 years old (47.80%). When the autistic child was born, most mothers and fathers were aged 26–30 (40.50%) and 31–35 years old (42.30%), respectively. Another child with ASD in nuclear and extended families was reported for 11.70% and 13.50%, respectively. Only 24.30% have seen a professional genetic consultant, and 19.8% have done genetic testing for affected children. The mean score of awareness of genetic services for ASD was 2.48 ± 3.30. Having medical insurance and another child with ASD in the nuclear family was significantly associated with a higher level of awareness (p = 0.01 and p < 0.001, respectively). Most of the participants have a positive perception of these services.

Originality/value
Regardless of demographic factors, participants have poor awareness of genetic services for ASD, likely because the primary physician did not recommend it upon diagnosis. Increasing health-care providers' knowledge about the current potential of genetic testing for ASD and educational campaigns for the public are critical components of using available genetic tests to improve ASD management.


Palm kernel shell and Palm kernel husk have been used to remove Barium, Zinc and Mercury from drill cuttings. Batch adsorption studies were carried out as function of pH, contact time and Carbon dosage. Barium, Zinc and Mercury were found to be pH dependent with optimum pH of 9 for all activated Carbon materials. Barium and Zinc APKS was 150mins, while Barium and Zinc APKH was 120mins. For Mercury both APKS and APKH attained maximum adsorption at 60mins. For maximum adsorption, the adsorbent loading was 5g for Barium and Mercury APKS, 3g for Zinc and 4g for Barium, Zinc and mercury APKH. Although Barium and Zinc did not exceed the regulatory limit, the equilibrium experimental data were found to best fit the Freundlich Isotherm model for APKH with R2 = 99.84% for Ba, 85.66% for Zinc and 89.92% for Mercury. The intensity of adsorption for Barium was 0.9420, 0.0710 for Zinc and 0.2935 for Mercury. Although their was ion adsorption of heavy metal ions at low concentration, the low intensity values below unity indicates that adsorption using Palm kernel shell and husk is not very favorable for the removal of Barium, Zinc and Mercury from drill cutting.


The Nirantarapadavyākhyā by Jajjaṭa (or Jejjaṭa) is one of the earliest and,therefore, one of the most important commentaries on the Carakasaṃhitā. Thiscommentary is incomplete, but sufficient portions survive to allow a study ofthe earliest form of medical commentary in India. The extant portions of thiscommentary are large sections of the Cikitsāsthāna and part of the Kalpasthānaand Siddhisthāna. The text of Nirantarapadavyākhyā by Jajjaṭa has never beencritically edited. In this paper, we present a text-critical edition and translationof the Nirantarapadavyākhyā on the Carakasaṃhitā, Cikitsāsthāna Chapter 2,Quarter 1 (CaCi 2.1) based on several copies of a lost palm-leaf manuscriptin Malayalam script and the printed edition by Haridatta Śāstrin publishedin 1941. In order to follow the intellectual development of potency-therapy(vājīkaraṇa) in the Sanskrit medical literature, the remaining three extant majorcommentaries are also translated from the existing printed editions. These threecommentaries are Cakrapāṇidatta's Āyurvedadīpikā in the eleventh century,Gaṅgādhara's Jalpakalpataru in the mid-nineteenth century, and YogīndranāthSen's Carakopaskāra in the early-twentieth century.


Abstract : This report contains the test results and raw fractographic data for over 180 fatigue cracks. Natural fatigue cracks were acquired in fastener holes in 7475-T7351 aluminum. Three specimen fastener hole configurations were considered: (1) open hole, (2) bolt-in-hole(passive), and (3) bolt load transfer. Both straight-bore and countersunk fastener holes were considered. Strain survey results for a double-reversed dog-bone specimen(designed for 15% bolt load transfer) are presented. The fractographic data in this report can be used to quantify the initial fatigue quality or equivalent initial flaw SIZE(EIFS) cumulative distribution for clearance-fit fastener holes. These data can be used to determine the initial flaw size for the durability and damage tolerance analyses of mechanically fastened joints.


In this paper, we introduce the notions of an iterated planar Lefschetz fibration and an iterated planar open book decomposition and prove the Weinstein conjecture for contact manifolds supporting an open book that has iterated planar pages. For $n\geq 1$, we show that a $(2n+1)$-dimensional contact manifold $M$ supporting an iterated planar open book decomposition satisfies the Weinstein conjecture.


Abstract Substituted acetamidomalonic esters and dl -2-acetamido acids were prepared for the screening program of the Cancer Chemotherapy National Service Center. The synthesis of these compounds was accomplished by conventional methods. The results of screening tests performed on these compounds in the tumor systems employed by the CCNSC are given. None of the compounds on the basis of these tests appears to be a useful antitumor agent, but the results of the tests aid in establishing other approaches to the problem of cancer chemotherapy.


Our numerical model of elliptical deformation of ring cores uncovers distinctly different behaviors of lower and higher order OAM modes. Degeneracy of modes, across topological charge and polarization are laid bare in simulations.


Ungulates are an important source of food for Wolverines (Gulo gulo), especially in winter when scavenging on carcasses is a primary means of obtaining food. However, Wolverines are also known to prey on ungulates. We followed fresh tracks of Wolverines pursuing Caribou (Rangifer tarandus) on six occasions on the tundra of northern Alaska in 2011, 2015, 2017, and 2018; all ended in a predation event after pursuits of 4−62 km. Exhaustion of the Caribou after long pursuits appeared to contribute to the success of predation attempts. Snow conditions appeared to be a factor in only one of the six cases.


This study was aimed at the performance of micro methanol steam reformer for channel widths optimization by simplified conjugate gradient method (SCGM) with minimum objective function of velocity standard deviation. A three-dimensional numerical model and optimal algorithm named simplified conjugate gradient method (SCGM) were built for predicting the dominating factors in channel widths. In the optimization searching process, the simulation model only includes the continuity and the momentum equations for decreasing the computational time. When the optimum channel width of different inlet flow rate and its distributions are obtained by SCGM with minimum objective function, the species and energy equations are applied to evaluate the performance of steam reformer. Distributions of velocity were predicted, and the methanol conversion ratio was also evaluated. In addition, the mole fraction of CO contained in the reformed gas, which is essential to prevent the catalyst layers of fuel cells from poisoning, is also investigated. Furthermore, the present simulation model was also compared with existing experiment data, and the close agreement was found. Results show that the methanol conversion ratio can be improved from 54.2% to 62.6% for the particular case at 0.6 cc/min flow rate if the channel widths are optimized. On the other hand, the mole fraction of carbon monoxide is increased from 2.85% (original) to 5.21% (optimal) at Q = 0.6 cc min−1 .Copyright © 2010 by ASME


The importance of biodegradable plastics made from renewable resources is becoming increasing important. Thus lactide; an intermediate to high molecular weight polylactic acids (PLA), is a key compound for the future of plastics. To achieve the high molecular weights from lactide, it is necessary that the lactide be substantially free of impurities. Another factor of importance is the stereoisomeric form of the lactide. While lactic acid exists in both a D and L stereoisomeric form, lactide has in addition a meso form. These isomeric lactides have differing stabilities and also give rise to polymers with different properties, making it necessary for some polymer applications to control the ratio of each isomeric form in the final product. Lactide is prepared by polymerizing the corresponding lactic acid to a relatively low molecular weight oligomeric polymeric acid, then heating the oligomer to depolymerize it to the lactide. Typically, this crude product contains more than 90 % lactides including any isomers and less than 10% impurities. Purification of this crude lactide with minimal energy requirements and the absence of solvents is critical to producing a superior polymer. SULZER's melt crystallization process has been successfully used for purifying chemicals employed for conventional plastics such as polycarbonate, polyamide and polyurethane. SULZER has been actively involved in the development and design of crystallization processes for purification of lactides since the early 1990's and has a number of commercial operations operating for several years. Crystallization is the only process that simultaneously removes impurities and other lactide isomers. It is possible to obtain lactide that is more than 99.95% pure using SULZER's melt crystallization process without the use of solvents. The crystallizers contain no moveable parts such as stirrers or filters thus making the equipment very reliable. The purification process consumes minimal energy, as the operating temperature is ideal. As the future inevitably will require continuing higher lactide purity to produce superior polymers from this renewable resource, Sulzer expects the importance of its melt crystallization process to grow to allow economically competitive production of this "green" plastic. This paper reviews the process involved in producing this environment-friendly natural product.


An efficient rotation based adaptive multichannel least squares lattice algorithm for multichannel filtering with different filter orders for each input channel is presented. It is shown that this algorithm is suited for adaptive nonlinear filtering based on Volterra and recursive polynomial system models. The new algorithm requires only orthogonal transformations offering superior numerical behavior. Its highly modular and regular structure facilitates VLSI and parallel implementations.<<ETX>>


To celebrate the bicentennial of William Smith's pioneering geological map of England, Wales and southern Scotland in 2015, the Yorkshire Philosophical Society and the York Museums Trust commissioned a walk-on geological map installation of Yorkshire in the Museum Gardens at York. This impressive 4 x 4 m mosaic by artist Janette Ireland used geological materials to demonstrate many of the important points illustrated by Smith. Details of the map including explanatory leaflets can be found at https://www.yorkmuseumgardens.org.uk/the-mosaic-map/. This however is not the first walk-on geological map installation in the county.


In this paper, the authors examine a popular media account of prophylactic mastectomy—the surgical removal of 'healthy' breasts for preventive purposes—focusing on the ways in which the account works to normalize what might alternatively be considered extreme preventive health behaviour. Although the procedure remains controversial, prophylactic mastectomy is increasingly presented as a treatment option for women considered to be at high risk of developing breast cancer. A discursive analysis focuses on how one woman's 'decision' to undergo prophylactic surgery of this type was accounted for in terms of two broad identity constructions or positionings: as 'mother', and as 'certain to die of breast cancer' in the absence of such surgery. It is argued that constructions of prophylactic mastectomy, such as that depicted in this account from a popular women's magazine, can be seen to draw on traditional gendered discourses, and on notions of responsibility central to the new public health. Such media accounts thus promote general acceptance of the procedure, and risk management more generally, as enterprising actions that reasonable, morally responsible, 'at-risk' women should undertake to maintain their own health and to care for their families.


Introduction: There are two historical paradigms in the Iranian family law: love law and libido law. The approach to surrogacy according to these two paradigms will be different. Understanding the two approaches is possible through understanding the four categories of love: 1. Libido: the passion of life and manifestation of sexual drive. 2. Eros: the romantic love and the material of poem and literature. 3. Philia: the mere love purified from libido like the relatedness of father, mother and their children. 4. Agape: the spiritual love in mysticism. Love law ceases at libido but love law promotes to philia passing through libido and eros. The paper explains two approaches to surrogacy and prefers the love approach to libido. For example, the legal theory which nullifies surrogacy, suffers from its libido perspective. Moreover, the doctrine which binds the surrogate mother to return the child to the commissioning family, only for the consideration and payment mentioned in contract, is a libidinal doctrine. The thesis of this essay discusses that the mother should be determined by philia and relatedness criterion not by libido. Materials & Methods: Surrogacy in this essay is studied from a philosophy of law point of view. After describing its theoretical foundations in legal principles, the essay tries to prepare a jurisprudential response to the "Is and ought problem" of surrogacy by referring to the Iranian literature and mysticism. Results: 1In libido law, the concept of marriage is equal to sexual intercourse but in love law the purpose of marriage is relatedness of a man and a woman to each other and their children. 2Libido law treats woman as an object and instrument, but love law tries to treat her as an end in herself. 3In the literature of libido, law borders pornography but in the literature of love law it has a chaste language. 4In libido love, this is only woman who has to remain faithful towards her husband but in love law the man is obliged to faithfulness to his wife and family. 5Libido law, in spite of the term, treats libido in a cursory and perfunctory manner, but love law respects the values of libido and puts it in its correct place. For example, in the libido law if a man and a woman undertake, under marriage contract, to abandon sexual intercourse, this contractual term will be correct and effective but in love law, the term is certainly void because of the serious role of sexual intercourse in the frame of marriage and in faithfulness of both. Conclusion: 1. The theory that invalidates the contract of surrogacy is a theory of libido law which rejects having the child without sexual intercourse. 2. The theory that obligates the surrogate mother to give the child back is also in libido sphere because the requisites of sexual intercourse are presumed superior than relatedness of surrogate mother to her born child. 3. On the other hand, the law should not have an inconsiderate conduct to libido. The continuity of philia differs from libido in being pure from lust and concupiscence, but we can not ignore the importance of libido in materialization of philia. The parents love their child because it is born after an amorous intercourse with a unity in the physical body of a man and a woman, and because the child is formed by their gametes. 4. Love is an accident in which human falls in with; it does not occur by choice. Therefore, the surrogate mother should not oblige herself, in her agreement, not to be attached to the child. Love is an act of God which frustrates the contract in this field; like any major force. 5. Parenthood is a legal fiction and a conventional presumption. In surrogacy, if the surrogate mother conceives, she is not the owner of the zygote like other normal or natural mothers. If the owner of zygote renders as mother and as she has not actually given birth to the child, like other natural mothers, she should not be presumed the mother by law. In the Iranian law, it is better to leave the case to judges and not to the legislature. The judge will presume the most related woman to the child as the mother. Regarding all circumstances, philia and relatedness in this field will be evidenced through the common sense of the judge. 6. The prima facie of the case is the most important evidence for judgment; the owner of the egg and the sperm who endorse surrogacy, as the last resort to parenthood, deserve the child and the burden of proof is on the surrogate mother to prove her prevailing philia. But, if a woman does not want to be pregnant because of aesthetic problems of pregnancy she has to expect not to be presumed as the mother of the child in the court. The burden of proof in this case is on the owner of egg to prove that her relatedness is more than the surrogate mother.


A new series of water treatment technique for industrial circulating cooling water is designed by CNOOC Tianjin Chemical Research Design Institute,and the technique can make the SDW which is corrosive using for the cooling water system as supplying water.It also can make sure the system run well.


A new acidic amino acid has been isolated from the hydrolysate of normal human urine. The chemical structure of the amino acid was determined to be alpha-amino-gamma, delta-dihydroxyadipic acid, based on its physical properties involving nuclear magnetic resonance, infrared and mass spectrometry as well as chemical degradation and chemical synthesis.


This article presents an insight into one of the e–learning pilot projects that were selected by the Educational Technology Unit (EduTech) of the Centre for Academic Development (CAD), University of Botswana (UB). This e‐learning package was designed and delivered to meet the needs of the course "Issues and trends in early childhood education" (EPI‐642), a three‐credit course required for the Year One, Master's Programme, in the department of Primary Education, University of Botswana. A flexi‐time, gradual, phase‐wise transition from traditional face‐to‐face teaching, teaching with electronic medium and to a SMART classroom (e‐learning lab) approach was followed to deliver this course. It resulted in a flexi‐time, student‐centred, e‐learning package that retained the learning qualities of traditional teaching and personal guidance and mentoring and enabled enhancement of research skills and certain computing skills in students.


The data concerning the structure of the symbiotic community (species composition, taxonomic and ecological structures) of the mollusks Dreissena bugensis (Andrusov, 1897) - a representative of the Ponto-Caspian faunal complex, which is actively distributed in the waters of Europe and North America - has been summarized. There are 7 species of obligate and facultative symbionts of different taxonomic groups (ciliates, trematodes, nematodes, etc.) in the symbiotic community of D. bugensis in the water objects of Ukraine.


This paper offers a multimodal approach of writing as an embodied interactional action, prefigured by the movements of the entire body, projecting going to write. It considers grassroots participatory democracy meetings as an exemplary setting for studying issues related to writing in public, for the public and on behalf of the public. In this context, a facilitator is in charge of writing down the outcome of the participatory discussion, in a way that is public, transparent and intelligible for the audience. On the basis of extensive video recordings, I study the methodic embodied practices that precede and lead to public writing. The analysis shows that the writing of proposals is contingent on the establishment of an agreement about them: clear agreement is followed by a straight and brisk walk of the facilitator towards the board, projecting the inscription. By contrast, when there are problems in establishing the agreement, his walk is more discontinuous. Finally, in case of persisting disagreement, the walk deploys in very different manners. Thus embodied movements of the facilitator are reflexively related to the agreed upon vs. disagreed status of the proposal that the facilitator is going to inscribe. This demonstrates how writing is strongly projected by walking; and how writing is observably done in a public, transparent, and revisable way as the product of a collective action.


This study evaluated the effect on Oxisol soil compaction of traffic by wood harvesting machines from different extraction distances carried out by a logging company located in Paraná State. The harvesting system was composed of a feller buncher, skidder and harvester, in which soil compaction was evaluated at four extraction distances and four depths by means of density, porosity and soil penetration resistance. Increased machine traffic resulted in the highest compaction in the soil surface layers on the extraction trail, with the highest intensity in the region near the edge of the stand and with values above the critical density limits. Soil penetration resistance was critical in the row of traffic over the stand with significant effects at a of 0.11 to 0.60 m, which is the recommended depth for soil preparation.


The individualized process of human aging occurs in the intersection of biological, cognitive, and psychological domains. Advances in the field of biochirality reveal new crucial determinants of aging at the molecular, cellular, and organism levels. All biologic macromolecules, including DNA, proteins, and lipids, exhibit a prevalence of chirality. Chirality and stereoselectivity are recognized as the fundamental properties of all life-supporting biomolecular systems. However, all homochiral molecules are vulnerable to multiple types of spontaneous aberrant modifications, including racemization. Indeed, several biomolecular structures, including amyloids, are known as the by-products of the major evolutionary pathway. Accumulation and aggregation of misfolded proteins are commonly recognized biomarkers of biological aging, neurodegenerative, immune, and psychiatric disorders. Aging, accompanied by the decline in health, independence, perceptual, cognitive, and decision-making abilities, is closely associated with the negative impacts of most typical psychological stress. Both aging and psychological stress aversively affect the immune, hormonal, and neuro-transmitting systems. In our view, at the protein level, the primary determinants contributing to the crosstalk of genetic, epigenetic, and psychological pathways of aging are the spontaneous post-translational modifications.


A simple valve-transistor cathode follower is described. Its main application is as a `head' amplifier for piezoelectric accelerometers which are remote from associated measuring equipment. A frequency range of 3 c/s to at least 20 kc/s is achieved with a battery drain of less than 40 mW and a noise level not exceeding 50 μV r.m.s.


By analyzing water resource allocation and management of Heihe River,Shiyanghe River,Talimuhe River,Ningxia section of Huanghe River and Nanan irrigation district of Nei Monggol,the article discussed the ecological and environment problems and the impact on economics development in middle reaches of basin in water resource allocation of arid area,and discussed the ecological and environment problems in water resource transform of Huanghe River irrigation district.


Abstract An evaluation of the ability of an integrated (slab) marine atmospheric boundary-layer (MABL) model to predict changes in the inversion and mixed-layer temperature and humidity using data from the Los Angeles-San Diego Basin is described. The model microphysics and initialization methods are evaluated separately. The Stage and Businger stratocumulus entrainment closure formulation is used. Standard radiative flux approximations (e.g., delta-Eddington) are employed with up-to-date cloud microphysical parameterizations. The assumption of well-mixed properties is relaxed to permit a constant vertical gradient that is a function of the surface flux and the entrainment rate. Initialization of the subsidence rate receives considerable attention and is analyzed using data from suitably spaced multiple stations and from a single station. Two cases, a cloud covered and a clear sky period, are examined. In both cases the island and shoreline data are from regularly reporting locations and from a research s...


The key steps for the synthesis of the title fragment (I) are kinetic resolution, Grignard reaction, Sharpless dihydroxylation, and for the first time, AIBN radical cyclization to construct the six-membered pyran system.


Thank you, Professor Bodman. I should like to add my thanks also to Professor Adele Ferdows and her Committee, to the University of Louisville, for their thoughtful local arrangements, and to Professor Bodman and his Program Committee for their good work.


Adopt a law on mediation and the mediator profession organization started and the idea that mediation is an important theme of the strategy for justice reform a priority in the Action Plan for implementing the judicial reform strategy 2005-2007. By adopting the law was intended to reduce the level of activity of courts and thus relieve them of a considerable number of cases and hence an increase of justice, by satisfying their interests.


In this paper, we present a novel descriptor called uniform rotation invariant gradient(URIG) aiming at texture classification under variant rotation and illumination condition. Instead of using URIG directly, a 2D descriptor can be formulated combining URIG with average of local pixels. Given a texture image, such 2D descriptors are extracted from every pixel followed by clustering. The centers of clustering can be viewed as a texton dictionary over which a histogram is computed as the representation of given texture image. Experiments are carried out on Outex and CUReT databases comparing to state-of-the-art approaches. Our proposed method achieved promising performance against illumination and rotation changes with least cost for representing histogram dimension.


Coffee Wilt Disease (CWD) or Tracheomycosis was first seen in 1927 in Central Africa Republic. From 1938 to the early 50's it spread on Coffea excelsa and attacked C. neo-Arnoldiana, to a lesser extend C. canephora var. robusta. At the same time a general decline of coffee trees in Ivory Cost was attributed to the same disease. It attacked two local varieties of C. canephora and C. abeokutae or Indenie as well. In Ethiopia, CWD infects Arabica coffee. From 1935 to 1960, coffee wilt became the most serious disease of Coffea sp throughout West and Central Africa. The damages were very severe and lead to the death of millions of trees. As a consequence, Coffea excelsa and related species as C. abeokutae disappeared from these regions. During the 50's the systematic elimination of affected plants over vast areas was required. Additionally, the collect of sources of resistance in both wild populations and in the cultivated varieties for use in breeding programmes should be undertaken so that resistant varieties could be developed and replanting could begin. These two strategies proved to be highly successful. The Coffee wilt disease "disappeared" towards the end of the 1960s, "reappeared" at the beginning of 1980's in DRC and 1993 in Uganda. Given the inefficacy of phytosanitary control methods, the impossibility of replanting on infected soil and the absence of commercial resistant cultivars, a genetic control strategy was initiated. Two lines of research were developed: a study of pathogen diversity and an analysis of the biodiversity of wild Coffea canephora trees in Uganda, which would be resistant to vascular wilt. (Resume d'auteur)


A fourteen-year-old Persian cat was referred because of poorly controlled diabetes mellitus despite insulin and dietary treatment. Clinical signs were severe polydipsia/polyuria (pupd), poor hair coat quality, stomatitis and hind limb weakness. At the time of initial presentation, he was treated with glargine insulin (0,75 IU/kg BID). A low dose dexamethasone suppression test (LDDST) revealed hypercortisolism (HC). The cat was additionally treated with trilostane, and remission of diabetes mellitus was obtained one year later. This case illustrates the importance of diagnosing an underlying cause of poorly controlled diabetes mellitus. Although hypercortisolism is rare in cats, it is important to consider the disease in these cases. The hypercortisolism in this cat was efficiently managed with trilostane, resulting in a good quality of life.


The effect of a microwave-assisted hydrothermal (MWH) treatment on the structural, thermal, and electrical properties of NiO/ZrO2:8 mol%Y2O3(YSZ)/CeO2 (60/20/20 wt.%) composite was investigated. Powders were synthesized by a hydroxide coprecipitation-impregnation technique, in which Ni and Ce oxides were coprecipitaed in a suspension containing YSZ. Simultaneous thermogravimetry and differential thermal analysis revealed that MWH treatment promotes the crystallization of coprecipitated phases. X-ray diffraction analysis was used for phase identification and the calculated lattice parameters indicated the formation of YSZ:CeO2 solid solution during sintering. Impedance spectroscopy measurements showed that the electrical properties of the composite samples were not significantly affected by the MHW.


Home automation provides convenient, comfortable, energy saving, safety and security to people. Nowadays mostly home automation systems are based on English speech recognition. In northern Pakistan where majority of the people speaks Pashto and the literacy rate is very low, due to which most of the people deprived from the use of home automation. The aim of this research is to provide a friendly interface to the illiterate Pashto speakers. In this research, Mel-frequency cepstral coefficient (MFCC) is used for feature extraction and k-Nearest Neighbors (KNN) as classifier. For training and testing the proposed model, data from 75 native Pashto speakers from zero(sefor) to nine(naha) has been recorded using Sony PCM-M10 recorder. The proposed method is simulated in MATLAB and implemented on Arduino. The results obtained from the proposed method are very satisfactory and achieved an overall of 78.8% accuracy.


This paper is to find out the proper statistical model for the inward and outward foreign direct investment(FDI) in Korea by industry and is empirically to analyze the industry-specific determinants of the FDI by using the panel data. This paper assumes that the current levels of inward FDI are based in the past levels of independent variables and examines the determinants by Fixed Effect Model taking into account both industry effect and year effect. Among the models of determinants influencing on the FDI, the 3-years lagged value model for the inward FDI and 2-years lagged value model for the outward FDI are the most proper ones explaining the relationship between the FDI and the industry-specific factors. With the models, the result of analysis shows that industry comparative advantage, advertising intensity, capital intensity, industry sales and industry concentration are positively significant in the inward FDI model, whereas R&D concentration and capital intensity are significant in the outward FDI. In particular, the industry comparative advantage is a significant variable in all lagged value models and it proves that inward and outward FDI is the best access to get the sources of industry comparative advantage.


Millions of Americans are under intense pressure to balance work and family responsibilities. The feeling of overwork is rampant, with nearly half of employees feeling overworked or overwhelmed by their workplace responsibilities. This manuscript argues for a suite of legal protections that would allow working families, especially single-parent and low-income families, basic access to the rights and protections of flexible work.


The theory of cyclic voltammetry of redox adsorbates based on the nonadiabatic kinetic models of Levich and Dogonadze (GMLD kinetics) is re-examined. It is shown that if generalized predictions of cyclic voltammetric behavior are sought, the model is applicable only over a small range of reorganization energies. It is well-known that at high reorganization energies Tafel plots simulated using both Butler−Volmer and GMLD kinetics give similar results; however, cyclic voltammograms simulated from GMLD kinetics at high reorganization energies do not reduce to the generalized Butler−Volmer model for cyclic voltammogram of redox adsorbates derived by Laviron (J. Electroanal. Chem. 1979, 101, 19). Two methods of solution to the cyclic voltammogram equation are considered:  a finite difference numerical solution and an analytical approximation. The analytical approximation enables a more rapid simulation of cyclic voltammograms. Methods for applying the model to real systems are suggested which include an equati...


MMC-based EV fleet integration system (MMC-EVIS) is a promising solution to promote the development of vehicle to grid (V2G) technology, then to make maximum use of EVs to provide ancillary service for the utility. However, due to the particularity of EV, the optimal design of the main parameters of power stage, such as the AC&DC voltage level and the cascaded module number of each arm and alike, is important to the safe and reliable operation of the system. Based on the multi-objective power management strategy, the optimal design criteria for main parameters including MMC modulation index, maximum arm current and peak charging power coefficient are put forward to obtain the security region for system operation in this paper. Detailed optimal configuration process is discussed. And a medium-sized MMC-EVIS model with rated power of 480kW, 1kV AC voltage and 48 EVs is developed in Matlab/Simulink. Simulation results indicate that the system parameter optimization is reasonable and necessary, which provides a reference for the construction and operation of the MMC-EVIS.


From the etymological point of view, the concept of education has its origins in the Latin roots "educo-educare" (to grow, to take care of), respectively "educo-educere", which means to lead, to guide. Education is a leading action. This statement emphasizes the etymological meanings, in the sense that any educational act involves directing the evolution of the individual to higher stages, defined by independence, autonomy, ability to integrate/adapt to the social environment (I. Comanescu, 1996). From a sociological point of view, the concept of education designates a complex activity that ensures the transmission of the accumulated information and the experience gained by humanity through a sequence of actions exercised consciously, systematically and organized by the educator on the educated, in order to transform him in an active and creative personality, corresponding to the historical-social conditions (A. Cazacu, 1992). How much does the education within the family mean today? It is a question that requires time for reflection, but we can also say that the concept of family refers to the family as a group of people directly related by kinship relationships, whose adults take responsibility for raising children, a responsibility that includes in it also its educational forms. This article comes to check certain philosophical reflections. We can say about education that it survives after everything that has been learned has been forgotten. Education is the best provision we can make for old age. The family is an important and responsible factor in education. Parents lead it and are responsible for it in front of society, for their happiness, and their children's lives. Education is the means by which parents pass on their own flaws or positive aspects to their children.


Abstract A young person's perception of his past, present, and future life is shaped during his adolescence. The potential/prospective self of an adolescent includes his ideas and plans concerning his future life and, therefore, constitutes an important source of his motives for activity and development. This paper presents results of its author's own research on the ways in which adolescents with visual disability receiving special education in the Silesian Voivodship perceive their own future lives. The theoretical part of the paper contains an analysis of the concept of self-perception and related concepts. Special attention is paid to defining different kinds of self-perception, analyzing their functions, and indicating factors that determine their development during adolescence. An overview of selected pieces of research on the self-image of the blind and visually impaired people allowed a description of the influence of self-perception on social and personal functioning of adolescents with visual disability.


This article considers the advice found on six internet sites written for people who are considering coming out. The article uses Edwards' (1994, 1995, 1997) script formulation theory to examine how the grammatical choices by the writers formulate the dispositions of the main actors in the texts: the advice seeker, LGB individuals, and the people to whom they come out. The writers' formulations are shaped by a view of coming out as the act of a reasonable, emotionally healthy, moral and loving lesbian, gay or bisexual (LGB) individual. It is argued that one of the purposes of these texts is to normalize coming out as a routine event and as a rational course of action for an LGB individual. Furthermore, the use of script formulation is seen to be characteristic of written texts and a strategy by which advice writers can legitimize themselves as qualified to give advice.


– All techniques deliver estimates of anisotropy, but to understand these in terms of fracture properties you have to assume a physical model and the measurements mean something different in each model. The discussion begins with a brief review of the nature and scale of real-world fractured rock systems, and then considers three simplified frameworks to represent this complicated reality mathematically. We review the following azimuthal techniques for quantifying seismic anisotropy:


Abstract Background : Families of patients with mental disorder endure remarkable hardship for coping with psychiatry symptom and they confront physical and emotional stresses. Maintaining and improving the quality of life is an important task for nurses. This study was designed to Determination of Quality of life in Caregivers of Patients with mental disorder in Fatemie hospitals of Semnan university of Medical Sciences. Method : A descriptive design was used. Samples consisted of Caregivers of Patients with mental disorder (Schizophrenia, Mania, Major Depressuon ( took part in this study. Data were gathered by questionnaire (Quality of life family version) in domains: physical, psychological, social and spiritual. Validity through content validity and reliability with a Cronbach's Alpha / was approved. Data were analyzed using SPSS software. Results : Most Caregivers of Patients with mental disorder are Female ( ) with a mean age of years and patient's wife ( ). The results of study showed that, majority of caregivers record at in physical ( . ), psychological ( ), social ( ) and in spiritual ( . ) as partly desirable level and the QOL scores of caregivers was . from . There was a significant association between quality of life and duration of caregiving (p = / ). Conclusion : copping with disease crisis and explore reasonable about further is more important. Nurses necessary to understand the necessity of family to support and give information. This issue improves Health and Well-being in families. Key words : Quality of life, caregivers, mental illness, Schizophrenia, Mania, Major Depressuon .


This chapter deals with expectations for stock returns over longer horizons, e.g. over the next decade. The chapter starts out providing an overview of how academics analyse the long-run outlook for stocks. It recalls that stock returns consist of yield, growth, and valuation change. Forecasting stock returns means forecasting these components. The chapter discusses ways to do so. It also discusses the empirical evidence. Finally, it presents a useful specific approach one can use to gauge the outlook for stocks in the long run.


Over the last 5 years, a series of related qualitative research studies have been conducted to better ascertain how Appalachian families from southeast Ohio define and practice family health within their households. A literature review about family health completed prior to the first study identified that the term family health is used frequently, but seldom defined. Definitions provided are usually from the professional rather than the family perspective and semantic slippage is prevalent within single investigative works. When definitions are provided, they most often reflect a functional perspective and rarely include biophysical measures. This program of research was an attempt to better understand family health from the family and community perspective. The three ethnographic studies used similar data collection and analysis methods. Two different counties were used for the research to provide access to different populations. Each study included eight families, a series of home interviews with multiple family members, taped and later transcribed semistructured interviews, key community informants, and observation. Data were analyzed using Spradley's (1979, 1980) ideas about domain analysis and Yin's (1994) ideas about continuous comparison and cross-case analysis. The first study, "Part 1: The Definition and Practice of Family Health," was a dissertation about family health in rural Appalachian families with preschool children (Denham, 1997) and served as the foundation for future research. This study was conducted in a rural


Abstract Currently, the design of reinforced concrete wall panels under eccentric axial loading only is carried out using empirical or semi-empirical methods. These methods involve approximations, which are not always reliable and being empirical, their scope of application is limited. In particular walls supported on all sides (i.e. two-way action behaviour), made of high strength concrete strength or high slenderness ratios have been given little treatment in research. In view of this, the authors have undertaken an extensive investigation on the development of a more reliable and accurate wall design equation. This paper initially presents a brief overview of an experimental program undertaken. The experimental results are compared to the proposed design equation. Also the proposed design equation is compared to results from previous studies on this topic, confirming that the new equation is accurate and reliable.


This note is concerned with the approximation of fault directions in relation to mutual detectability in detection filter problems. As an efficient system representation for analysis of detection order, we utilize the observer canonical form, by which we show that the invariant zero and the detection order can be analytically calculated by a set of polynomials associated with fault directions. Noting that this approach clearly shows the condition for the detection order to be plural, we propose a fault direction approximation method, which increases its detection order, for obtaining a mutually detectable system. Regarding the resulting degradation of fault isolation performance as a disturbance, we present its quantitative analysis and propose a method of selecting a threshold in order to guarantee proper fault isolation.


The visible spectral characteristic and the reaction condition of complex of Dibromo-o-Nitrophenyl Fluorone(DBONPF) and Cefaclor(CFC) were investigated by spectrophotometry which DBONPF as a developer.The results showed that the concentration of CFC obeyed the Beer's law in the range of 0.07356 ~ 0.3678 μg/mL and the regression equation was A=1.5456ρ + 0.0351(ρ μg/mL) with the correlation coefficient r of 0.9998,the apparent molar absorptivity was 6.03 × 104 L.moL-1.cm-1and the detection limit was 0.0396 μg/mL.Further more,the reaction mechanism had been explored.The proposed method has been successfully applied to the determination of CFC in table,and the results were satisfying.


1. Potential energy is the term used for energy in "storage,"  A rock could be pushed off a table and move towards earth, there is a natural attraction from gravity  "Thomas" trains can move closer together, there is a natural attraction from the magnets  A coil spring wants to push away when it is compressed, a natural repulsion of the metal coils  All objects that have the potential for motion have potential energy  The potential energy of an object can be converted to kinetic energy  Energy is released any time two objects with an attractive force are allowed to come together. Think about a rock falling to the Earth (because of the attractive force). Your foot is in the way. Is energy released to your foot?  To separate two objects with attractive forces, some E must be absorbed from the surroundings. For kids" toys to rise above the ground to the shelf, they must absorb energy from the surroundings (me). For a rock to rise above the ground, it absorbs energy from it"s surroundings (you).


Proving the existence of speculative financial bubbles even a posteriori has proven exceedingly difficult so anticipating a speculative bubble ex ante would at first seem an impossible task. Still as illustrated by the recent turmoil in financial markets initiated by the so called subprime crisis there is clearly an urgent need for new tools in our understanding and handling of financial speculative bubbles. In contrast to periods of fast growth, the nature of market dynamics profoundly changes during speculative bubbles where self contained strategies often leads to unconditional buying. A critical question is therefore whether such a signature can be quantified, and if so, used in the understanding of what are the sufficient and necessary conditions in the creation of a speculative bubble. Here we show a new technique, based on agent based simulations, gives a robust measure of detachment of trading choices created by feedback, and predicts the onset of speculative bubbles in experiments with human subjects. We use trading data obtained from experiments with humans as input to computer simulations of artificial agents that use adaptive strategies defined from game theory....


This qualitative study reports an investigation of the nature of interactional competence at various levels of achievement in the context of role-play speaking assessment. The focal point of this study is on how examinees jointly accomplish the interactional work involved in proposal sequences in role-play interaction. Based on a conversation analysis of a corpus of role-play interaction, I argue that distinct sequential organizations and interactional features found across examinees' levels serve as critical validity evidence for assessing interactional competence. Various shift markers and stepwise transitions were present in higher-level examinees when they initiated and shifted actions in role-play interaction. However, lower-level examinees' opening turns were typically forwarded without establishing a shared understanding relevant to an upcoming action. When the examinees responded to various proposal sequences, coherent and sufficient topic organizations were recurrent in higher-level performances. The examinees, regardless of levels, managed to close the role-play interaction well. I discuss the implications of the demonstrated link between the recurrent interactional features and examinees' interactional competence for future research into speaking assessment and teaching.


Within the context that Greece promises a success story in the fight against the disease, this paper proposes a novel method to study the evolution of the Greek COVID-19 infection-curve in relation to the anti-COVID-19 policies applied to control the pandemic. Based on the ongoing spreading of COVID-19 and the insufficient data for applying classic time-series approaches, the analysis builds on the visibility graph algorithm to study the Greek COVID-19 infection-curve as a complex network. By using the modularity optimization algorithm, the generated visibility graph is divided into communities defining periods of different connectivity in the time-series body. These periods reveal a sequence of different typologies in the evolution of the disease, starting with a power pattern, where a second order polynomial (U-shaped) pattern intermediates, being followed by a couple of exponential patterns, and ending up with a current logarithmic pattern revealing that the evolution of the Greek COVID-19 infection-curve tends into saturation. The network analysis also illustrates stability of hubs and instability of medium and low-degree nodes, implying a low probability to meet maximum (infection) values at the future and high uncertainty in the variability of other values below the average. The overall approach contributes to the scientific research by proposing a novel method for the structural decomposition of a time-series into periods, which allows removing from the series the disconnected past-data facilitating better forecasting, and provides insights of good policy and decision-making practices and management that may help other countries improve their performance in the war against COVID-19.


The effects of stubble management and crop rotation on suppression of soilborne pathogens was studied in wheat cropping soils taken from established trials at Moree, Warialda and Croppa Creek in northern New South Wales, Australia. Biological resilience was evaluated in two ways: by measuring severity of take-all when the pathogen (Gaeumannomyces graminis var. tritici) was introduced to soil, and by assessing displacement of Fusarium pseudograminearum, the cause of crown rot of wheat, from buried straw pieces. No effects of stubble management or rotation with sorghum were found on suppression of either the introduced or resident pathogens at the Moree site. At Warialda and Croppa Creek, the severity of take-all in pot bioassays was significantly lower in soils from zero-tillage plots with stubble retained than in cultivated plots where the stubble was burnt. This effect was seen in soils from both continuous wheat and wheat-chickpe a rotation treatments. There were no consistent differences between treatments in soil microbial biomass or respiration, or in soil carbon contents. Stubble retention also significantly increased the rate of displacement of F. pseudograminearum from infested straw at Croppa Creek, but not at Warialda. The results showed that, at two out of three sites, retention of crop residues increased the ability of the soil to resist the effects of introduction of a major plant disease.


The first purpose of this study was to determine the norm-referenced predictive validity of maximal oxygen consumption (VO2) max estimated from the progressive aerobic cardiovascular endurance run (PACER, FITNESSGRAM®; Cooper Institute for Aerobic Research, Dallas, TX) performance by 3 separate formulas: the Leger, Mercier, Gadoury, and Lambert (1988) 8- to 19-year-old equation; the Leger et al. adult equation; and the Ramsbottom, Brewer, and Williams (1988) equation. Norm-referenced intraclass stability reliability coefficients (n = 19) were determined to be .96 for PACER and estimated VO2 max values. Only the VO2 max values estimated from the Leger et al. adult equation (47.29 ± 7.02 vs. 50.45 ± 8.01 rnL · kg-1 · min-1 measured; p < .0001) were shown to be valid (r = .82; standard error of estimate [SEE] = 4.59; Error = 5.58; percentage of participants whose measured VO2 max fell within ± 4.5 mL · kg-1 · min-1 of estimated VO2 max = 59.7; N = 60 female participants ± 59 male participants). The second pu...


Capsule Farmland bird species occurred at low densities and were highly aggregated in a small proportion of available pastures, stubble fields and farmyards. Aim To document the current distribution and abundance of farmland birds and their habitats within the lowland farmland of Britain in winter. Methods Over three winters volunteer observers visited a stratified random sample of 1090 1-km squares within which they counted a suite of 30 farmland bird species and mapped agricultural habitats. Results For individual species, less than 10% of habitat patches were occupied and densities in occupied patches were low. Several differences were apparent in patterns of relative abundance compared to the 1980s. In particular marked declines of Tree Sparrow and Corn Bunting were apparent. The national distribution of cereal stubbles was localized. A large proportion of most species was found in grassland. Positive associations at the patch scale were apparent for improved grassland by invertebrate feeders and cereal and maize stubbles and farmyards, mostly by granivores. Conclusion Many farmland passerines are highly aggregated, even within particularly favoured field types. These results are consistent with winter food resources being highly localized and the need to create more food-rich patches if declines are to be reversed.


The industrial tea waste reinforced jute polyester composites (ITW-JPC) were prepared by hand lay-up method for six different wt% (0%, 3%, 6%, 9%, 12%, and 15%) at 115˚C temperature. The effect of industrial tea waste filler on mechanical, physical, structural, and thermal properties in jute polyester composites were evaluated. It is found that tensile strength and flexural strength improved continuously with increasing filler loading up to 9wt% but decreased at 12wt% due to weak interfacial bonding and irregular distribution of filler and matrix. The maximum value of elongation at break (%) and Rockwell hardness were found in 0wt% and 15wt% composites respectively. The hardness increases when the resistance of the materials to the deformation increases. It is seen that water absorption and soil degradation are enhanced for all composites with the accumulation of filler content and time. The structural examination and functional group identification were investigated by using Fourier Transformation Infrared (FTIR) analysis. Thermal analysis of ITW-JPC showed that thermal degradation of composites started almost at the same time and the degradation of composites was occurring in three stages. Surface morphology and interfacial properties such as internal cracks, and fiber pull-out were examined through scanning electron microscopic (SEM) analysis.


Amain task for teachers ofmotor skills is to draw the . learner's attention to certain aspects of the movement so errors can be prevented or detected more effectively. However, little is known about the relative effectiveness of different methods of directing the learner's attention to their movements. In an earlier study, Sherwood and Rios (2001) used verbal instruction to guide the learner's attention to a specific limb in a bimanual aiming task when both limbs were unseen. When attention was focused on a single limb in acquisition, spatial errors were reduced in that limb compared to the nonattended limb or when participants were prompted to pay attention to both limbs simultaneously. The finding was replicated in a second experiment where the participants decided what limb or limbs to pay attention to during practice. Overall, the study showed that attentional focus could reduce spatial errors in aiming tasks. A natural extension of the Sherwood and Rios study might be to investigate other techniques by which attention might be directed (e.g., vision). In one of the few studies on attention, vision, and bimanual control, Swinnen, Jardin, and Meulenbroek (1996) demonstrated that when the participant could see one limb in a bimanual circle drawing task the relative phase difference (i.e., the visible hand preceded the nonvisible


The usual Heisenberg uncertainty relation for position and momentum may be replaced by an exact equality, for suitably chosen measures of position and momentum uncertainty. This "exact" uncertainty relation is valid for_all_ pure states, and is sufficiently strong to provide an axiomatic basis for moving from classical mechanics to quantum mechanics. In particular, the assumption of a nonclassical momentum fluctuation, having a strength which scales inversely with uncertainty in position, leads from the classical equations of motion to the Schroedinger equation.


1
Introduction

2
Pes of Azo Compounds

3
Pes of Azoxy Compounds

4
Pes of Hydrazo Compounds

5
Conclusion

6
Acknowledgements

Keywords:

photoelectron spectroscopy of hydrazo, azo, azoxy, compounds;
PES of azo compounds;
diazene and electronic structure of azo group;
PES of azoxy compounds;
hydrazine and acyclic hydrazines;
PES of hydrazo compounds


Mitochondria contain multiple copies of mitochondrial DNA (mtDNA), which encode genes essential for cellular bioenergetics. When more than one type of mtDNA genome exists within the mitochondrion, or between mitochondria, a condition termed heteroplasmy occurs. In this respect, it has been long observed that differences in mtDNA heteroplasmy involving pathogenic mtDNA mutations generate a broad range of clinical phenotypes. For instance, it is known that increasing levels of the transfer RNA leucine [tRNALeu(UUR)] 3243A > G mutant "result successively in diabetes, neuromuscular degenerative disease, and perinatal lethality" (1); however, the specific molecular mechanisms driving these diverse clinical phenotypes have been not clearly understood. In PNAS, Kopinski et al. (1) advance our understanding of this mystery by manipulating the levels of mtDNA containing either a normal (3243A) or pathogenic (3243G) mtDNA tRNALeu(UUR) mutation in a human bone osteosarcoma cybrid model. For these studies, they generated cell lines that had either 100% normal (3243A) or 100% pathogenic (3243G) mtDNA homoplasmies, in addition to a series of cybrids harboring different percentages of normal and pathogenic 3243A > G mtDNA heteroplasmies. Using these cell lines, they performed various measures of metabolism, including metabolic tracing and NAD+/NADH ratios, and, importantly, examined transcriptional and epigenetic changes in the nuclear genome. Another key feature of this work is that all cell lines (homoplasmic and heteroplasmic) shared the same nuclear genome, meaning that any observed metabolic and epigenetic changes were solely attributed to differences in mitochondrial genetics. This report provides direct evidence that changing levels of tRNALeu(UUR) 3243A > G heteroplasmy on the same nuclear background changes aspects of mitochondrial function (as anticipated), but, perhaps more importantly, also causes changes in nuclear gene expression via histone modifications modulated by levels of mitochondrially generated acetyl-CoA and α-ketoglutarate (αKG) levels. For example, Kopinski et al. …

[↵][1]1To whom correspondence may be addressed. Email: scottballinger{at}uabmc.edu.

 [1]: #xref-corresp-1-1


The Heritage Centre brings together the former Borough Museum and Local History Library to offer a wealth of information and fascinating displays about the history of Greenwich.


EDTA-bonded multi-connected carbon-dots (EDTA–C-dots) were prepared from carbon dot precursors and complexed with Eu3+ to give Eu3+-coordinated EDTA-bonded multi-connected carbon dots (Eu–EDTA–C-dots). Whereas EDTA–C-dots were readily soluble in DMSO, Eu–EDTA–C-dots could not be easily dissolved in DMSO, water, or other common organic solvents. The newly prepared materials were thoroughly characterized. The X-ray diffraction results showed that no crystalline phase of Eu oxides (europium oxide or europium hydroxide) could be observed in Eu–EDTA–C-dots. The infrared and UV-Vis spectra showed that coordination with Eu3+ ions did not damage the structure of the EDTA–C-dots. It was found that EDTA could be easily grafted on the surface of carbon dots and EDTA had minimal influence on the photoluminescence of the carbon dot matrix. In contrast, the existence of Eu3+ ions strongly quenched the photoluminescence of Eu–EDTA–C-dots. The measured and fitted decay lifetime indicated that Eu–EDTA–C-dots possessed two photoluminescence decay processes, i.e., radiative recombination and non-radiative recombination.


Johan Zoffany RA: Society Observed, New Haven: Yale Center for British Art, 27 October 2011–12 February 2012; London: Royal Academy of Arts, 10 March–10 June 2012

Johan Zoffany RA: Society Observed edited by Martin Postle, New Haven: Yale University Press, 2011, 320 pp., 225 col. and 5 b. & w. illus., £40.00 hdbk


Background: Perceived stigma is considered to be one of the most important factors that have a negative influence on people with epilepsy. All types of perceived stigma further exert stress and restrict normal participation in society. Method: Institutional based cross-sectional study was conducted from January 10, 2017 to February 10, 2017. All people with epilepsy in west Shewa zone were source population. The sample size was determined using single population proportion formula and 363 study subjects were selected. To select the study subjects the hospitals found in West Shewa Zone was stratified and the calculated sample size was proportional allocated. The study subject was selected using systematic random sampling. Data was analyzed using SPSS version 20. Result: Prevalence of perceived stigma was 34.4% among People with epilepsy on follow up at west Shewa public hospitals. Age group 35 up to 44 years (AOR = 0.8, 95% 0.102, 0.52), no formal education (AOR = 8.8(2.29, 33.82)) and grade1-8th (AOR = 6.07, 2.05, 17.97), less than one year on (AOR = 5.66, 2.09, 15.38), 2-5 years (AOR = 4.88 , 2.09, 11.33) and 6-10 years duration of illness (AOR = 3.71(1.55, 8.87), depression symptoms(AOR = 29.66(12.55, 70.09),anxiety symptoms (AOR = 2.44(1.23, 4.84) were significantly associated with perceived stigma. Conclusion: Prevalence of perceived stigma of PWE is high in the present. Age, educational status, duration of illness, depression and anxiety symptoms were significantly associated with perceived stigma among people with epilepsy.


The structuralist thinking that generates industry and technology policies does not arise in a vacuum since all economic policies have structuralist implications. As economic policies change over time, so do the structuralist implications that can be drawn from them. An examination of specific major postwar Western European economic policies reveals that they do tend to influence the nature of industry and technology policies. But these industry and technology policies do not provide simple recipes for changing the industrial mix so that it is relevant to contemporary economic policy goals.


Enzyme Nomenclature, Elsevier Pubhishimsg Company, Amsterdam, 1965, p. 140. Os-TNST bound tionspecificallv, as determined with boiled mitochotidria. The sectiomis were then staitie(l with umramiyl acetate in order to bridge uramiiuns to the osmiumns amid at the same time reveal mnitochon(lrial structure. As showmi its Fig. 2, the formazami deposits cams be seen not only as demise particulate deposits bust sometimes appear to aggregate imi a helicallike maimer with a separatiomi of 100 A betweeti coils. The presemit localization of succinic dehydrogenase activity has ample support from biochemical experimemits. It was suggested by numerous imivestigations that most of the SDH emizyme activity, if mmot all, lies its the inner membrane and cristae of the mitochondria (e.g., Chance. Proc. N. Y. A cad. Sci., 1966) vet it was tiot possible to ascertaits whether the activity was within or on the ouster surface of the membramies. Recetmtly, usitig atm osmiophilic tetrazohium salt, TC-NBT, Seligmami amid co-workers (J. Histochein. (ytochem. 15: 1. 1967; 15: 752. 1967) reported the staimiitsg on the cristae tsiembratme which emscr()ached oti the ititracristac spaces. The presemit method shows a clear imit racrist ai localization, yet makes possible high resolution electromi miiicroscopic study for numerous other problems where other methods are limited. l)etails will be reported later in a more complete paper.


The work is a study of the geometry of the molecules via molecular mechanics of the main monoterpenoids found in the oil of Lemon Tahiti. Lemon Tahiti is the result of grafting of Persia file on Rangpur lime and has no seeds. A computational study of the molecular geometry of the molecules through molecular mechanics of the main monoterpenoids compounds present in fruit oil is described in a computer simulation. The fruit has active terpenoids compounds: alfa-pinene, beta-pinene, limonene and gama-terpenine. The studied monotepernoides form two groups of distribution characteristics of fillers and similar electrical potentials between groups. Since alfa-pinene and limonene present, major and minor moment of electric dipoles, respectively.


The manipulation of the orbital angular momentum (OAM) spectrum in new wavelengths generated by frequency conversion has a wide range of applications in quantum information technology and modern communications. Here, the second harmonic generation of a vortex beam in a nonlinear crystal with an inhomogeneous refractive index is considered. It is shown that by using a segmented oven and generating a controllable temperature gradient along the thickness of the nonlinear crystal, a transverse phase mismatch can be induced in the vortex beam. Accordingly, the OAM spectrum of the vortex beam can be changed by generating new OAM components in the spectrum. Compared with the nonlinear Bragg diffraction method, the presented method has the advantage of longer interaction length and higher efficiency.


OFDM(orthogonal frequency division multiplexing) technology is a digital multi-carrier modulation technology,and the wireless multi-path fading channel has good transmission characteristics.This paper describes the design short-wave radio system,which uses the OFDM technology to overcome the interference by multipath fading.The modeling by Simulink and the simulation under the Rayleigh fading channels and Gaussian channel indicate that the performance is fairly improved.


Unlike the past, recent reading theories and models define reading comprehension as an interactive process involving both reader and text characteristics (Day and Park, 2005). This interaction is influenced by different factors one of which is background knowledge. This study aimed at investigating the effect of background knowledge on the reading comprehension of two groups of homogenous students majoring in Theology and Psychology respectively. Two ESP tests were given to the two groups, one on theology and the other one on psychology, each one consisting of 40 multiple-choice items. The researchers wanted to see which of the two groups performed better in the test related to their major. The results of the study show that there was no significant difference between the two groups' performance in the two ESP tests suggesting that background knowledge is not so important in performing in ESP tests, although there were differences between the two groups regarding their knowledge and abilities on the whole. The implications of this finding will be discussed at the end.


The concept of InterPlaNetary (IPN) Internet was proposed by National Aeronautics and Space Administration (NASA). The IPN Internet could provide Internet-like services crossing interplanetary distances in support of deep space exploration, which includes backbone network, access network, and planetary network. The IPN backbone topology control strategy based on Libration points was studied in this paper. Firstly, the location and stability of Libration point is simulated by celestial mechanics. Secondly, a novel Hierarchical-Cluster model of IPN backbone network is proposed to simplify topology design. Then Intra-Cluster Link and Inter-Cluster Link are analyzed in detail. Finally, the optimal handover moment is gotten by critical angle which to use relay theory, and the total number of handover times is calculated within a relative period between Uranus and Neptune cluster. Streszczenie. Koncepcja interplanetarnego Internetu IPN zostala zaproponowana przez NASA. W artykule omowiono strategie kontroli topologii szkieletu bazującą, na punkcie Libration. Na wstepie przeanalizowano stabilnośc systemu a nastepnie model hierarchiczny klastrow. Wreszcie analizowano przelączenie polączen miedzy stacjami bazowymi - handover. (Hierarchiczna topologia klastrow w interplanetarnym Internecie)


The invention relates to an electrolyte and a lithium-ion battery comprising the same. The electrolyte comprises an organic solvent, a lithium salt and an additive, wherein the additive comprises a hydrogenated thiophene-boron trifluoride coordination compound and a sultone compound. The electrolyte simultaneously comprises the hydrogenated thiophene-boron trifluoride coordination compound and the sultone compound; decomposition of the electrolyte on the surface of an electrode can be inhibited under the common synergistic effect of the hydrogenated thiophene-boron trifluoride coordination compound and the sultone compound; and corrosion of an acidic material generated by the electrolyte on a solid electrolyte membrane is effectively reduced, so that the cycle performance of the lithium-ion battery at a room temperature and a high temperature and the storage performance at the high temperature can be improved.


Let $\Gamma$ be a finite-covolume Fuchsian group and Comm$(\Gamma)$ be its abstract commensurator. Then Comm$(\Gamma)$ contains the solvable Baumslag-Solitar groups $\langle a ,b : a b a^{-1} = b^n \rangle$ for any $n > 1$. Moreover, the Baumslag-Solitar group $\langle a ,b : a b^2 a^{-1} = b^3 \rangle$ has an image in Comm$(\Gamma)$ that is not residually finite. It follows that Comm$(\Gamma)$ is not locally residually finite, and hence is not an inverse limit of locally residually finite groups (e.g., linear groups, mapping class groups of hyperbolic surfaces of finite type, or branch groups). This completes the picture of local residual finiteness of abstract commensurators of irreducible lattices in semisimple Lie groups, formed by Armand Borel, Gregory Margulis, G. D. Mostow, and Gopal Prasad. Our proofs are computer-assisted.


A collaborative activity on "Measurement Uncertainty (MU) Training" under the auspices of the European Metrology Network for Mathematics and Statistics (Mathmet) is underway. This abstract reports on the progress to undertake surveys of existing training courses on MU, software for MU evaluation, and classroom examples to support the understanding of methods for MU evaluation. An appreciable number of training courses, software and examples have been identified and are currently under review. These tools and materials will be analysed and categorised according to their main features and characteristics. Special attention will be given to their adherence to the JCGM guidelines (i.e., JCGM 100:2008, JCGM 101:2008 and JCGM 102:2011). It is hoped that the knowledge assembled in this activity will help practitioners to make good choices about appropriate material to support their training needs, as well as help developers of training material to ensure good coverage of their training products and target them at user needs.


A viewer uses a remote control to specify the viewing channel (CH) and the viewing date and time of a program he wishes to watch. A reception method selection unit determines whether the program is currently being broadcast or the program was broadcast previously based on the viewing date and time, and selects the reception method. URL information of a program distribution server storing past programs is included in the service description table (SDT) of the service information (SI), which is transmitted together with the broadcast program, and is stored in an SI information storage unit. If the program selected by the viewer is a past program, an IP data reception unit connects to the program distribution server on the basis of this URL, transmits the viewing date and time to the program distribution server, and receives the desired past program via an IP network.


The human immunodeficiency virus type 1 (HIV‐1) envelope glycoprotein gp120 is a vaccine immunogen that has been studied extensively. To enhance the immune response of cells against HIV‐1 gp120, we tested the coexpression of gp120N with interferon‐γ (IFN‐γ) as an immune adjuvant. Two recombinant prokaryotic plasmids were constructed: the pET44b‐HIV‐1‐gp120N plasmid construct carried the HIV‐1 gp120N gene (pET44‐gp120N), whereas the pET44b‐HIV‐1‐gp120N‐IFN‐γ plasmid construct carried a fusion gp120N‐IFN‐γ gene (pET44b‐gp120N‐IFN‐γ). Target protein expression was achieved in E. coli BL21 (DE3) cells by chemical induction. To test the immunological activity of the proteins, mice were injected with a control, gp120N, or the fusion gp120N‐IFN‐γ protein. The serum and spleen cells of the mice were collected for immunological detection. Results showed that specific T lymphocyte proliferation and the expression of the Th1‐type cytokines (IL‐2 and IFN‐γ) were higher in the gp120N‐IFN‐γ group than the other two groups (P < 0.05). No difference was observed in the expression levels of the Th2‐type cytokines (IL‐4 and IL‐10; P > 0.05). These results suggest that IFN‐γ plays a prominent role as an immune adjuvant when coexpressed with HIV‐1 gp120N. IFN‐γ enhances the specific cell immune response of mice against HIV‐1 gp120. Anat Rec, 292:381–386, 2009. © 2009 Wiley‐Liss, Inc.


A framework for datamodeling is proposed which is both fonnal and concise. It is constructed around the concepts of objects and their mutual functional relations. has a complete datalanguage based on first order logic and a diagram technique. Transfonnations to other frameworks for data modeling are discussed.


Career guidance of university students is a professional job.It has higher demands on the teacher who is engaged in college students' career guidance.Aiming at the problems existed in career guidance staff,this paper puts forward the measures to improve the construction of the career guidance staff from four aspects.


A street lamp remote monitor system based on a GPRS (general packet radio service) network relates to street lamp monitor systems, adopts the advanced GPRS network, integrates various advanced technologies such as computers, communication, electrical mechanics, automatic control and the like and realizes real-time monitor and management of street lamp illuminating systems and street lamps. The system improves roadway illumination quality and service quality, increases maintenance and repair efficiency, guarantees urban integral lighting rate of a city and perfectness ratio of equipment, further reduces energy consumption by the aid of energy-saving measures, relieves labor intensity, avoids unnecessary wastage of electric energy, labor and materials, and accordingly increases integral social benefit, management benefit, economic benefit and environmental benefit. In addition, the street lamp remote monitor system analyzes data conditions acquired by all street lamp monitor terminals in server weather conditions, adopts corresponding emergency measures, avoids major traffic accidents, and provides power guarantee on lighting progress of the integral city.


During the past decades, programming methodology has seen an improvement by structured programming and object-oriented programming (OOP), leading to software that is more reliable and easier to develop. However, software engineers are still dealing with problems in processing associated documentation. Literate programming was introduced by Donald Knuth in the early 80's as an approach to produce programs together with their documentation in a way that is aimed at consumption by humans rather than by compilers. However, dated and complex features, dependence on formatting and programming language, and a lack of methodology prevented the method from gaining in popularity. In this thesis, we propose an approach to "integrate" OOP with literate programming in order to present and document the whole design in a consistent and maintainable way. In our approach, both program code and corresponding documentation are generated from the same source. The resulting documentation consists of code chunks with detailed explanations, as well as automatically generated class diagrams with varying levels of detail. A tool, Spark, has been developed and applied to the design of a Transit Information System from requirement analysis to testing. Spark was also used in its own development.


A new set of stable chiral bicyclo[2.2.1] diene ligands were prepared from (-)-bornyl acetate 49, and were employed in the rhodium(I)-catalyzed asymmetric 1,4-addition of arylboronic acids to fumarates. In this catalytic system, rhodium-diene complex (1.0 mol%) generated in situ from chiral diene 53a and [RhCl(C2H4)2]2 successfully yielded the corresponding adducts with good to excellent chemical yields and excellent levels of enantioselectivities (up to >99.5% ee). This methodology was demonstrated by its utilization in the enantioselective total synthesis of 3-(2-methoxyphenyl)pyrrolidine (an α2-adrenoceptor antagonist) and asymmetric synthesis of N-benzyl-3-phenylpyrrolidine.


Background Both obstructive sleep apnea (OSA) and periodic limb movements of sleep (PLMS) are common in the sleep laboratory. The severity of OSA can be improved by using continuous positive airway pressure (CPAP). However, increasing evidence has shown an elevated periodic limb movement index (PLMI) in patients with OSA who use CPAP, although the pathophysiology is still unknown. This meta-analysis aimed to investigate changes in PLMS after using CPAP and the potential pathophysiology of these changes. Methods Clinical trials in adult humans investigating the comorbidity between PLMS and CPAP were identified and analyzed using random-effects model meta-analysis. Results This meta-analysis included 14 studies comprising 2,938 patients with OSA. The PLMI was significantly increased after using CPAP with a difference in means of 1.894 (95% confidence interval = 0.651–3.138, p = 0.003). Subgroup analysis showed that CPAP was only significantly associated with an increase in PLMI in the patients without PLMS at baseline (p = 0.045) and in those with a baseline body-mass index <30 kg/m2 (p = 0.045). The use of CPAP, apnea-hypopnea index, and arousal index were positively correlated with changes in PLMI. Conclusion These characteristics may serve as qualitative predictive indicators of changes in PLMI after CPAP usage. Further analysis of the quantitative relationships between PLMI and the predictive indicators may be warranted. Trial Registration PROSPERO (registration number: CRD42021252635).


Objective: This study was designed to determine the Total phenol, flavonoid content, antioxidant and free radical scavenging properties of different solvent extracts of Piper umbellatum . Methods: Different solvent extracts evaluated with DPPH radical scavenging activity and Reducing power activity. Results: The presence of phenol and flavonoid showed highly in the methanol extracts than ethyl acetate and acetone extracts. All the extracts have various level of antioxidant activity. Methanol solvent extract have good extraction and show significant antioxidant activity. The effect of reducing power of methanol extract revealed good antioxidant activity compare with other tested extracts. Conclusion: On the basis of the above results we concluded that methanol extract of Piper umbellatum whole plant extracts shows significant antioxidant activity than ethyl acetate and acetone extracts. Keywords: Piper umbellatum, Antioxidant, DPPH, FRAP assay, Polar, Non polar solvents


Purpose – The purpose of this paper is to examine how Bank of America Merrill Lynch is achieving gender diversity through an initiative aimed at women returning to the workforce after having a family and a break from their career.Design/methodology/approach – It is a case study that outlines how the Returning Talent program was developed and implemented and its ongoing improvement based on participant feedback.Findings – Over 50 percent of the women who participated in the 2012 program have now returned to work. The program raised the profile of the financial services sector and Bank of America Merrill Lynch as an employer of choice for women.Originality/value – This case study is of value to organizations in any sector looking to retain skills and talent, help employees achieve a balance between family and work, and build a strong employee brand.


This paper discusses the results of experimental research aimed to investigate the potentials of different types of innovative jacketing materials used to retrofit reinforced concrete columns. Carbon fiber reinforced polymer (CFRP) wraps and fiber-reinforced mortar (FRM) jackets were used as retrofitting materials. Steel fibers, synthetic fibers, and cellulose fibers were added as reinforcement to mortar that is used as retrofitting jacket for reinforced concrete columns. To evaluate the effectiveness of these retrofitting techniques, column specimens were prepared and tested. The test results of 9 column specimens with synthetic and cellulose fiber-reinforced mortar jackets, 12 columns with steel fiber-reinforced mortar jackets with 3 different volume fractions (1%, 2%, 3%), and 9 columns retrofitted with CFRP wraps were investigated. The column specimens had square sections with 4-10mm diameter steel as main bars. The dimensions were limited to the size that can be accommodated for axial testing up to failure using a Universal Testing Machine. The confinement effect was quantified by obtaining the individual contribution of each material that comprised the reinforced concrete column specimen and subtracting them from the actual load being resisted. This was done by monitoring the strains of the steel and concrete and relating the measured values to the stress-strain relationships of the materials. The percentage of the confinement effect was obtained in order to evaluate the effectiveness of the contribution of the different materials used in retrofitting techniques. The paper presents the results of the experimental program including the corresponding analysis and comparison of the effectiveness of the different retrofitting materials.


Variations in the Sun's luminosity have become, almost overnight, an active and productive field of astrophysics. There is now a nearly unbroken time series of precise data, from two separate satellites, beginning in late 1978 and running to the time of this writing. The study of these solar variations has jumped to a level of activity that might be expected in any field suddenly presented with a three-decade improvement in data quality. This improvement has been created largely by Willson's (90-93) Active Cavity Irradiance Monitor (ACRIM) on the Solar Maximum Mission (SMM). This was the first satellite to have been repaired in space by a manned mission; the repair was tremendously important for the study of solar variability. The variations so far seen have been as large as approximately 0.4% over a time scale of a week. The irradiance has also exhibited a steady decline since 1980 of the order of 0.02% per year. A review of temporal variations is given by Frohlich (3 1 a). In this review, we concentrate on solar luminosity variability due to magnetic activity. The precision of the ACRIM while operating in its normal mode approached 1 0 ppm of the mean solar irradiance, when averaged over a day. At this level of precision, the Sun's output is almost always changing. Another experiment, the Earth Radiation Budget (ERB) on the Nimbus-7 satellite, has produced an even longer record of solar variability measurements, though with less precision (35). The data from the two spacecraft have revolutionized the field within the past six or seven years.


A suspension system with hybrid electromagnets made of HTS coils and normal conductor coils consumes little power and has larger suspension gap. In this paper the mathematical model of this hybrid suspension system is introduced, its characteristics are analyzed, and a controller is designed to ensure its fixed suspension gap. The simulation proved that the controller can meet the performance specifications


The deformation of nitrogen bubbles in transformer oil with various DC electric fields was studied experimentally and theoretically. The bubble deformation was visualized by a high-speed digital camera. The major axis of the bubble was elongated along the direction parallel to the applied electric field, with the elongation increasing as the electric field magnitude increased. The electrical Weber number (We) was used to correlate the electric field magnitude and the electric permittivity of the working fluid to the bubble aspect ratio (AR). The experimental results indicate that the bubble aspect ratio increases with increasing We. The total electrical stresses were calculated on an actual bubble shape including the electrostriction stresses.Copyright © 2006 by ASME


ABSTRACT A 52 year-old man with Erdheim-Chester Disease (ECD) (a non-Langerhans polyostotic sclerosing histiocytosis) had next-generation sequencing (NGS) performed as part of his diagnostic workup. In addition to the tissue BRAF V600E mutation that is found in over 50% of ECD cases, he was also found to have a JAK2 V617F alteration in cell-free circulating tumor DNA (ctDNA) (liquid biopsy). The latter was thought to be an "incidental" finding, perhaps due to clonal hematopoiesis (though this usually occurs in older individuals), as his blood counts were normal and he had no splenomegaly. Approximately 13 months after the ctDNA test showing JAK2 V617F, he developed anemia, thrombocytopenia, and splenomegaly. Marrow biopsy then showed megakaryocytic atypia and markedly increased marrow fibrosis, consistent with WHO grade 2 of 3 myelofibrosis. Therefore, the patient was determined to have ECD with a typical BRAF V600E mutation, as well as primary myelofibrosis, with the latter diagnosis manifesting clinically over one year after the JAK2 V617F was first detected in ctDNA. He recently was started on the JAK2 inhibitor ruxolitinib. This case demonstrates that genomic alterations detected by liquid biopsy for evaluation of specific malignancies already present may serve as an early harbinger of hematological disease.


BACKGROUND: Presently, treatment of epilepsy with standard anti-epileptic drugs is associated with a number of shortcomings inviting us to study newer agents that would overcome these problems or search for the drugs or substances, which would enhance the efficacy or reduce the dose or toxicity of these standard anti-epileptic drugs. Ganaxolone (GNX) (3α-hydroxy-3β-methyl-5α-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator of GABA A receptors, may represent a new treatment approach for epilepsy. AIM: To evaluate the effect of Ganaxolone on maximal electroshock (MES) induced and Pentylenetetrazol (PTZ) induced convulsions and also their effect in combination with conventional antiepileptic drugs (CAEDs). MATERIAL AND METHODS: Wister strain albino rats weighing 200-250 gm were used. Effects of Ganaxolone (5 &10 mg/kg) alone and in combination with standard drugs were studied in MES and PTZ induced seizure models. Abolition of tonic hind limb extension was an index of anticonvulsant activity in MES, while for PTZ seizures; failure to observe clonus for 5sec duration for 30min was the index. Following that, percentage inhibition was calculated. STATISTICS: ANOVA followed by Newman-Keuls Multiple Comparison Test was used for analysis of data between the groups. RESULTS : In MES seizures, significant antiepileptic activity was observed with 10mg of Ganaxolone compared to control group but has less activity when compared to that of Phenobarbitone. In PTZ induced convulsions, the anti-epileptic effect of Sodium Valproate was higher than Ganaxolone, but both were statistically significant as compared to control. In PTZ-induced seizures, augmented effects were obtained when Ganaxolone was combined with sodium valproate i.e. 55%. CONCLUSIONS: The results provide a lead for potential benefit of adding Ganaxolone to Sodium Valproate in the treatment of epilepsy, which needs to be explored further.