This paper presents a rapid, operational method for estimating at-surface albedo applicable to Landsat and MODIS satellite sensors for typical cloud-free, low-haze conditions and sensor view angles less than 20°. At-surface albedo estimates are required input to various surface energy balance models that are applied operationally. The albedo calculation method was developed using the SMARTS2 radiative transfer model and has been applied in recent versions of the University of Idaho METRIC model as a component of the surface energy balance for determining evapotranspiration. The albedo procedure uses atmospheric correction functions developed to require only general humidity data and a digital elevation model. The atmospheric correction functions have a reduced structure to enhance their operational applicability in routine instantaneous surface energy balances and to estimate evapotranspiration. The method does not require high levels of knowledge in atmospheric physics and radiation transfer processes, c...


The mating behavior of Musca autumnalis De Geer consisted of a sequence of events; a distinct precopulatory behavior, seizure, and copulation. However, the seizure may not result in copulation nor in sperm transfcr. Tcn percent of mated females were infertile. Although vision played some role in sex recognition, olfactory and tactile senses were both involved.

Males and females started mating 36 and 48 hours after pupal eclosion, respectively. The optimum mating age of the face fly was 5-6 days. One male inseminated as many as 8 females during a 24-hour period; the average was 4. The average period of mating with sperm transfer was 66.2 minutes, with an observed range of 25-135 minutes.

Sperm transfer did not occur until 4 minutes after copulation began. The sperm could be stored in the female spermathecae for 28 days after a single insemination. Though the face flies mated in the absence of light, the presence of light resulted in a significant increase in the number mated. Fly density and cage size, within the limits studied, appeared to have no effect on the frequency of mating.

Deletion of blood from the fly diet for 5 generations did not adversely affect mating behavior.


iAbstract Background: Technology development has brought about the society with a sedentary life style and an increase in number of chronic diseases. Therefore, to change the pattern of physical activity in adolescents, the recognition of factors affecting such activities is of crucial importance. Objective: The aim of this research was to investigate the relationship between the pattern of physical activity in adolescent girls and their mothers' physical activities, attitudes, and some demographic characteristics. Methods: This cross-sectional stud was carried out on adolescents 226 girls aged 11-18 years in 2010. The study population was chosen using a cluster sampling method. Data were collected using a questionnaire of three sections including demographic data, adolescent's physical activity pattern, and attitude and pattern of physical activity in mother. Data were analyzed using chi-square test and Pearson correlation coefficient. Findings: Of 226 girls, 50% found to have 2.07 hours of moderate to strong physical activity while 26.5% with a sedentary life style. A significant relationship between the adolescents' physical activity pattern and the mother's physical activity and regular exercise was demonstrated (p<0.005). Also, there was a significant relationship between the adolescents' regular exercise and the mothers' exercise. Statistically, a significant correlation between the mothers' attitude and educational degree and the level of physical activity was shown. Conclusion: According to our results, a sedentary life style among female adolescents is higher than expected which is associated with mother's pattern of physical activity and affected by the attitude and educational level of mothers. Therefore, it is recommended that part of the educational programs to increase the level of daily physical activity in adolescent girls to be focused on mothers.


We report the viscosity (η) and thermal conductivity (k) enhancement in a stable magnetic nanofluid containing particles size <10 nm as a function of volume fraction (vol %), shear rate, magnetic field, and time. Without field, the η enhancement of nanoparticle is much larger than that of k. In a nanofluid with 0.078 vol %, the k/η ratio is tunable from 0.725 to 2.35 by controlling the applied field. Our results show that magnetic nanofluids with tunable k/η ratio can be used as multifunctional "smart materials" for miniature cooling cum damping applications.


Metamaterials are artificial composite materials that exhibit further properties neither available in the nature nor observed in its constituents, or enhancing the composite features relative to the individual properties of its constituents. Among them, we can highlight the Chiral Metamaterials (CMM), which present, besides negative refractive indices, high rotation angles of the polarization plane rotation [1]. Regarding to CMMs manufacturing, several techniques can be found: (i) the traditional one, wherein helical inclusions are dispersed in a dielectric host medium [2] and (ii) the newer based on the Printed Circuit Board Technology [3]. Besides its lower cost of manufacturing, the latest technique is featured by its designability and easiness of characterization using commercial software. In this communication a comparative parametric study focused on the variation of the polarization plane rotation angle (θ) versus different geometric parameters of several plane CMMs is performed. A. Structures under analysis Along this work two sets of planar structures implemented in PCB and exhibiting 3D chirality are analyzed in W-band (75-110 GHz). The first one, called mutual twist structure, is composed of chiral [3] (Fig. 1a) or achiral [4] (Fig. 1b) designs printed on both sides of the PCB with a relative rotation angle (φ) between each face. The second set, named specular structures, presents a 2D chiral geometry on one side of the PCB and its enantiomer, with or without rotation, on the other face (Fig. 2) [5]-[7]. B. Structures characterization Applying the parameter retrieval algorithm published in [8] the aforementioned structures are characterized by obtaining the transmission (t++ and t-) and reflection (r++ = r-= r) coefficients of both right(+, RHCP) and left(–, LHCP) handed circularly polarized waves. In t++ notation, the first subscript corresponds to the circular polarization type of the transmitted wave, and the second one refers to the circular polarization type of the incident wave. The optical activity introduced by the chiral medium generates a rotation of the polarization plane (θ), which can be calculated from: ( ) ( ) ++ − −   θ = −   1 arg arg 2 t t C. Parametric study As it was previously mentioned, one of the main features of the CMM is the high values of the polarization plane rotation that they produce. Thus, in our parametric study, we focus our attention on analyzing the CMM structure geometric characteristics dependence on the rotation of the polarization plane. As example, the rosette-type structure will be tested (see Fig. 1). Fig. 3 shows the variation of θ vs frequency for different values of the most significant parameters of the structure: relative twist between the rosettes (φ), line width (w) and unit cell side length (g). At this point, it is important to note that its 3D chirality is due to the relative twist (φ) existing between the stamps of each face. From Fig. 3a, it can be seen that, since for φ = 0 the polarization plane of the transmitted wave does not rotate (θ = 0), the structure is achiral. In contrast, when φ is increased the CMM sample shows chirality. Additionally, Fig. 3b shows that an increasing of w produces an enlarging of the rosette electrical length and, consequently, a reduction of the structure operating frequency. Finally, in Fig. 3c the effects of the unit cell side length are depicted. It can be seen that when the unit cell size length is increased, the distance between neighboring cells enlarges and, consequently, θ is reduced. In order to go further, the behaviors of same type of structures are compared. Thus, Fig. 4 presents the variation of θ versus frequency for each group of assemblies. In all cases the Rogers RO3003 dielectric with εr = 3, tg δ = 0.0013 and 5 mils (127 μm) thickness is used. From Fig. 4a, it can be seen that, for the same φ and dielectric thickness, the crosses provide greater rotation angles than the rosettes do. Meanwhile, the rosettes present the advantage of being a more compact geometry than the crosses. Thus, for a given operating frequency, the rosettes unit cell will be smaller than the crosses one. The reduction of the unit cell geometry allows placing a greater number of rosettes per unit of area. Finally, for the specular structures (see Fig. 4b), a very different behavior is observed between the responses of the squared, L-shaped and wheeled rosettes.


Introduction Heinrich Cornelius Agrippa & Sixteenth-Century Magic The Supernatural in Giordano Bruno's Natural Philosophy Early Modern England's Belief in Fictional Witchcraft Fictions of Alchemy & Angelic Communication in the Confusion of Religious & Magical Fiction in Marlowe's Doctor Faustus Madness & Damnation: The Consequences of Macbeth's Magic Witchcraft, Political Scandal & the Theatrical Moment of Middleton's The Witch Alchemy & Witchcraft in The Drama of Ben Jonson Magic in the Tempest: Shakespeare's Critique of Rough Art & Harsh Reason.


Injection pressure in diesel engines has an important effect on the engine performance and soot formation. During performing the experimental work, the measurement of the torque, power, specific fuel consumption (SFC) and soot formation values in the diesel engines is a time consuming work and it also requires specific tools, an expert. In addition to the difficulties mentioned earlier, some of the operating points can be only investigated and evaluated because of difficulties of measuring the parameters at the operating conditions. In this study, to overcome these difficulties, an artificial neural network (ANN) is used for prediction of performance and soot formation in diesel engines. The training data for ANN is obtained from experimental measurements. In comparison of performance analysis of ANN, the deviation coefficients of torque, power, SFC, and soot formation for the test pressure conditions are less than 1.66, 3.2, 2.89, and 3.47, respectively. The statistical coefficient of multiple determinations for the investigated cases is about 0.9934 to 0.9983. The degree of accuracy is acceptable in predicting the parameters of the system. So, it can be concluded that ANN provides a feasible method in predicting the system parameters. Key-Words: Artificial neural network, injection pressure, diesel engine


This paper shows that the option to default on foreign debt increases the cost of capital in emerging economies. This result arises in a consumption-based asset pricing model in which the decision to default on foreign debt is endogenous. The optimal default decision implies that stock prices in emerging economies become more sensitive to real economic shocks, and therefore more volatile, as the probability of default increases. Since stock markets are not integrated internationally, the increase in volatility is compensated by an increase in the expected excess return to stocks. I calibrate the model with plausible structural parameters and show that time variation in volatility and expected return can be economically relevant. The model can be solved in closed-form, and provides testable implications connecting stock prices in an emerging market to the spread over US Treasuries at which the country's foreign debt is traded in international markets. The model's time-series predictions are con…rmed in Brazilian data from January 1992 to October 2005. Stock market returns and changes in the sovereign yield spread are contemporaneously negatively correlated. The expected excess return and volatility of the emerging stock market increase with the sovereign yield spread. A cross-sectional implication of the model is also supported empirically: a conditional CAPM, in which the sovereign spread is the conditioning variable, explains a larger fraction of the dispersion of average excess returns across Brazilian industry portfolios than a static CAPM. Keywords: Asset pricing, emerging markets, sovereign default, real options JEL number: F34, G12, G15 I thank my advisors Mark Seasholes and Rich Lyons for steady encouragement and support. I am grateful to Pierre Collin-Dufresne and Greg Du¤ee for very helpful comments and suggestions. I also bene…ted from discussions with Bob Anderson, Christine Parlour, Mark Rubinstein, Jacob Sagi, Richard Stanton, Johan Walden and Nancy Wallace. All errors are mine. Financial support from CAPES and Dean Witter Foundations made this research possible. Contact information: Sandro C. Andrade, UC Berkeley Haas School of Business, 545 Student Services Bldg., Berkeley CA 94720-1900; Tel: 510-717-9847; E-mail: firstname.lastname@example.com .


Content Based Image Retrieval gives the path to retrieve the needed information based on the image content. The earlier versions of CBIR was based on Local Binary Pattern, Local Derivative Pattern and Local Ternary Pattern. These methods extract information based on the distribution of edges, which are coded using only two directions. The performance of these methods are little less and thus it can be improved by differentiating the edges in more than two directions. The performance is increased by four direction code, so called local tetra pattern (LTrPs) for CBIR. This method encodes the relationship between the referenced pixel and its neighbors based on the directions that are calculated using the first-order derivatives in vertical and horizontal directions. This project proposes generic strategy to compute LTrP in horizontal, vertical and diagonal derivatives.


In this paper, a new recursive implementation of composite adaptive control for robot manipulators is proposed. We investigate the recursive composite adaptive algorithm and prove the stability directly based on the Newton-Euler equations in matrix form, which, to our knowledge, is the first result on this point in the literature. The proposed algorithm has an amount of computation On, which is less than any existing similar algorithms and can satisfy the computation need of the complicated multidegree manipulators. The manipulator of the Chinese Space Station is employed as a simulation example, and the results verify the effectiveness of this proposed recursive algorithm.


Objective: to identify the predisposing factors in the literature falls in the elderly. Method: this was about a review in databases Scientific Electronic Library Online (SciELO) and Google Scholar (Google Scholar) and the library collection of UNIPAMPA, using the descriptors: falls and falls in the elderly. Inclusion criteria were: 1) Publication of the period 20002009, 2) publication which deals expressly falls in the elderly, and the exclusion criteria: 1) Publications International, 2) Subjects of falls in older people focused on specificity. Results: we found 16 articles on the subject proposed the review, which were used for preparing the same, and two books on the subject. The inadequate environment presents itself as one of the most significant factors in the occurrence of falls, in addition to changes resulting from age and use of medications. Conclusion: falls interfere with the quality of life to undermine the day-day limit of the elderly when the outputs of some activities of daily living. There are prevention methods that can be used to avoid the drop, as the organization's environment. Descriptors: accidental falls; aged; causality.


With the evolving economic conditions and forces of globalization, it has become a need to adapt to changes for the organization. For higher productivity and satisfactory human resources, the organization must embody its culture with its needs. This study aims at understanding the differences in organizational culture and perception of change capacity amongst employees in public and private sector organizations through gap analysis. The objective of this study is to conduct a gap analysis on the existing and preferred status of culture in public and private sector organizations and exploring the perceptions of change capacity at the managerial level. The rationale behind the study is that nowadays organization must come out of traditional work cultures and adapt to changes with due respect to expanding their capacities to manage the human resources more effectively. According to the resource-based view, employees are the resources and assets to the organization. Consequently, organizations need to figure out their needs and evaluate, rectify and implement strategies that enhance the well-being of an organization. The study uses gap analysis and thematic analysis over a sample of 120 employees to estimate the differences in organizational culture and perception of change capacity amongst the employees of public and private sector organization.


Previous studies have demonstrated tight coordination between pursuit and saccade target selection mechanisms utilizing simple colored stimuli (Krauzlis et al., 1999). The technique of adding noise to stimuli to limit discriminability has been employed to compare decision-making between saccades and perception (Beutter et al., 2000). W e have now used a similar technique and have also limited visual sampling time. This allowed us to directly compare the accuracies of pursuit and saccade decisions during responses that ranged from chance to near perfect.


The invention constituting the multiplexed network and to the front end, in a large switch for connecting the switch output end to the rear end, to a 2n × n multiplexed switch fabric constituting the front end of the multiplexing network. In implementing a prior art high-capacity switch was mostly in the form to extend the entirety of the n × n switch. However, this method is to configure the switching system n2-port filter, n number of first-in-first-out selection unit, n shared first-in-first-out selection unit and n, so the output must be composed of a request for a significant amount of logic gates, and the hot-spot traffic phenomenon in this case hayeoteul caused by the concentration of cells in a part of the input port, it is possible to encounter situations in which the use efficiency of the entire port is falling. In addition, if using an n × n switches constituting the mass of the switch there is a significant amount of damping performance may occur because basically consists of a Banyan network (Banyan network). In the present invention, it minimizes the logic gates required to configure a large-capacity switch, an equal operation load of the output port, and a whole to increase the efficiency of use of the port, VD extracted so as to minimize the routing tag portion, a first-in, first-out selector It provides, shared first-in-first-out unit, an output unit, and 2n × n multiplexed switch-part cell factor.


The repurposing of hemoproteins for non-natural carbene transfer activities has generated enzymes for functions previously accessible only to chemical catalysts. With activities constrained to specific substrate classes, however, the synthetic utility of these new biocatalysts has been limited. To expand the capabilities of non-natural carbene transfer biocatalysis, we engineered variants of Cytochrome P450BM3 that catalyze the cyclopropanation of heteroatom-bearing alkenes, providing valuable nitrogen-, oxygen-, and sulfur-substituted cyclopropanes. Four or five active-site mutations converted a single parent enzyme into selective catalysts for the synthesis of both cis and trans heteroatom-substituted cyclopropanes, with high diastereoselectivities and enantioselectivities and up to 40 000 total turnovers. This work highlights the ease of tuning hemoproteins by directed evolution for efficient cyclopropanation of new substrate classes and expands the catalytic functions of iron heme proteins.


Within some significant circles, where hegemonic representations of the idea of 'science' are produced, certain orientations of scientific research are carried out, and science and higher education policies are made and applied, references to the alleged existence of two kinds of knowledge, one of which would have 'universal' validity, and 'the other' (in fact the several others) would not, are frequent and do have crucial effects over our academic work. Although some outstanding authors within the very Western tradition have criticized from varied perspectives such universalist ambitions/assumptions, and although many colleagues have reached convergent conclusions from diverse kinds of practices and experiences, such hegemonic representations of the idea of science are still current. The acknowledgment of this situation calls for a deep debate. This article responds to such a purpose by attempting to integrate into the debate a reflection on the shortcomings of hegemonic academic knowledge to understand social processes profoundly marked by cultural differences, historical conflicts and inequalities, as well as significant perspectives formulated by some outstanding intellectuals who self-identify as indigenous, and the experiences of some indigenous intercultural universities from several Latin American countries.


A modified method is proposed for predicting the lateral displacements of the ground caused by installation of soil-cement columns. The method is a combination of the original method derived on the basis of the theory of cylindrical cavity expansion in an infinite medium and a correction function introduced to consider the effect of the limited length of the columns. The correction function has been developed by comparing the solutions obtained using the spherical and the cylindrical cavity expansion theories for a single column installation. Both the original and the modified methods have been applied to a case history reported in the literature, which involves clay soils, and the predictions are compared with field measurements. The advantage of the modified method over the original method is demonstrated. Finally, the modified method has also been applied to a case history involving loose sandy ground, and the calculations show that the method can also be used for this type of soil provided that appropriate consideration is given to the volumetric strain occurring in the plastic zone of soil surrounding the soil-cement columns.


The formation of macroporous honeycomb gold using an electrochemically generated hydrogen bubble template is described. The synthesis procedure induces the formation of highly active surfaces with enhanced electrocatalytic and surface enhanced Raman scattering properties.


According to the characteristics of stand management, this paper puts forward the general designing frame, the way of acquiring and expressing knowledge, the mechanisms of deducing and the method of dealing with imprecise information for stand managing expert systems, and also develops the prototype of them. Based on the different age, stand density and site index which the user inputs, this system can help make appropriate decisions for stand management, and make them scientifically.


In the light of the problems existing in online shopping in China at present, this paper advances some corresponding countermeasures for promoting the healthy development of online shopping.


Inventories are assets owned by the company include goods belonging to the company with the intent to sell within a certain period of business or inventory -Items that are still under construction or production process or raw material inventoriesuse in the production process. The choice of method of inventory is important because every decision has economic consequences. Conflicts of interests among economic agents can arise when a company must choose a method which supplies should be applied. This arises because of the differences in the economic results of each method of inventory. Selection of inventory accounting methods in Indonesia refers Inventory Accounting Standard (SFAS) No. 14 which gives the freedom for companies to use one of the alternative methods of inventory that is First In First Out (FIFO) and average (Average). The object of this research is industrial and chemical sectors listed in Indonesia Stock Exchange during the years 2013 to 2015. The sample in this study sebanya 34 companies out of 10 companies using FIFO and the 24 companies using the average method. Statistical analysis tools used in logistic regression with significant level of 5%. The results showed that the structure of ownership and leverage ratios positive effect on inventory accounting methods. The size of the company's profit before tax and the current ratio does not affect the accounting method of inventory. keywords: ownership structure, company size, profit before tax, leverage ratio, the current ratio.


ObjectivesTo observe the clinical efficacy of patient self-controlled intravenous analgesia (PCIA) with tramadol after thoracotomy.MethodsSixty patients subjected to thoracotomy were randomly divided into two groups:①PCIA group (n=30), 800 mg tramadol plus 5 mg droperidol was diluted to 100 ml with normal saline (NS). The sustained infusion was 2 ml/h plus PCIA 0.5 ml for each time , whereas the lockout time of safety was 15 min.②Control group (n=30), intramuscular injection of pethidine was scheduled intermittently as patients required. Patients were followed up postoperatively and PCIA using times, pain scores, respiratory rate, blood pressure, sedation status, and side effects such as nausea, vomiting, pruritus, urine retention, etc. were recorded.ResultsStatistically significant differences in pain scores and sedation status existed between PCIA and control groups. The pain control rate of PCIA group achieved 100% .ConclusionTramadol as PICA drug for postoperative pain shows better clinical efficacy.


Iontophoresis is effective in anesthesia blocking for evaluating the source of pain. When extraoral anesthesia is required, the author has discovered there is less resistance from the patient if iontophoresis is offered as an alternative to needle injections in selected sites.


Integrated optical (IO) switches and modulators are based on the electrooptic effect obtained by applying a voltage between electrodes fabricated on the surface of a crystal (for example, LiNbO 3 ). In this paper, we calculate the change in the optical propagation constant in single mode Z -cut LiNbO 3 :Ti-diffused waveguides for a variety of electrode configurations. These calculations are compared to experimental data from IO devices. The calculations predict the observed variations in switching voltage with wavelength and electrode separation.


Accepted for publication 25 July 1991 Abstract Background-In animal models of circulatory shock and heart failure concentrations of the endogenous opioid peptide # endorphin are raised and opioid receptor blockade improves haemodynamic variables and survival. This study was performed to identify whether acute myocardial ischaemia provokes the release of # endorphin in humans. Methods-Observational study in a university cardiology centre. Serial measurements of endorphin made by specific radioimmunoassay were correlated with other clinical and neuroendocrine variables that were measured prospectively. Fifty five patients with acute myocardial ischaemia and 26 patients undergoing elective coronary angioplasty of the left anterior descending coronary artery were studied. Result&-# endorphin concentrations were


ABSTRACT An area that is being scrutinized as a more effective method of educating and preparing security professionals is that of ethical hacking. The purpose of this research is to examine a more proactive approach to adequately prepare future information security professionals. Future careers in security may require that professionals be equipped with the necessary skill sets to combat an ever-growing presence of unwanted activity throughout the Internet. Many argue that future information security professionals need to have the same skill sets as attackers in order to adequately recognize and defend networks from intrusion. This research defines ethical hacking and examines the pros and cons of ethical hacking pedagogy as a viable approach for teaching network security to future professionals. The analysis includes the concept of ethical hacking education with an emphasis on ethical and legal concerns associated with ethical hacking pedagogy. The research concludes with an overview of existing best practices in ethical hacking education highlighting a hands-on approach as well as the inclusion of soft skills needed to complement the technical hard skills for future information security professionals. Keywords: Ethical hacking, information security instruction, ethical hacking pedagogy INTRODUCTION The prominence of information technologies and increasing dependence on technological infrastructures continues to infiltrate all of society. It may be argued that some concern stems from the apparent lack of security inherent within information technologies and systems. Of particular importance is our growing reliance on the Internet and networking capabilities. The Internet has provided vast opportunities in a wide array of areas not possible in prior years. Today we are able to access massive amounts of information, and connect in unprecedented ways. Along with the positive capabilities provided by the Internet and networking, unpleasant aspects also infiltrate in unexpected ways. While various crimes have existed for many years, the Internet and information technology have brought computer crime into our homes and businesses in unimaginable ways. Criminals of today have a new platform for conducting activities, and many individuals are so bewildered at the subsequent onslaught from these endeavors that in many cases only reactive measures may be implemented. The purpose of this research is to analyze the use of an ethical hacking pedagogical approach to improve information security instruction. A hacking methodology appears to be a more offensive and proactive approach for information security instruction. This approach may be effective to better prepare future information security professionals to combat unethical hacker intrusions associated with the Internet and computer networks. Future information security professionals would be better equipped to combat intrusions if equipped with the knowledge and skill sets currently used by attackers. In order to equip those professionals, students must be prepared to fight the ever-growing challenges associated with effectively securing computer networks. This research defines ethical hacking pedagogy followed by an overview of this approach in information security instruction. The ethical and legal implications are addressed regarding teaching students how to hack. Finally, a review of best practices in the field are examined featuring components necessary to use ethical hacking as a viable approach for teaching network security to students. A qualitative study was conducted focusing on the research question underlining the analysis of an ethical hacking pedagogical approach to improve information security instruction. Information was acquired utilizing the Belk Library and Information Commons at Appalachian State University. Searches were conducted in the databases and journals at the university. The databases are organized by subject matter, and "computer information systems" provided the majority of the literature. …


My research group currently focuses on investigating mass and charge transport within nanostructured materials to gain design principles of highly efficient separation and sensing media. Recent progress in controlled nanostructure fabrication and highly sensitive measurement techniques enables us to explore molecular-level understanding of fundamental transport processes. We employ monolithic materials comprising aligned cylindrical nanoscale pores/domains as model systems, and measure mass/charge-transport phenomena within these materials using single-molecule fluorescence and electrochemical techniques. Such measurements will clarify factors that determine the transport properties of nanostructures, and thus will afford information required to design nanostructured materials optimum for chemical separations/sensing, water purification and desalination, and chemical catalysis. This Commentary describes the recent achievements and possible future directions of our charge-transport studies. These studies aim to quantitatively understand parameters that govern the efficiency of charge transport based on electron hopping through redox moieties confined within nanoscale structures. Fundamental knowledge obtained will directly aid in engineering redox-active mediator layers for enzyme-based electrochemical sensors and for electrocatalysis, and may also provide valuable insight into long-range electron transfer in biological systems and organic electronics. In addition, our studies will reveal the uniqueness of nanostructures as chargetransport and chemical recognition media. Note that this Commentary does not describe our mass-transport studies using single-molecule fluorescence techniques, which are based on close collaboration with Prof. Daniel Higgins (Kansas State University) and were discussed in our recent perspective and review articles. My interest in nanostructured materials was initiated while I was a postdoc with Prof. Richard Crooks at Texas A&M University (2001–2004). During this time, I studied resistivepulse detection with a carbon nanotube pore for characterization of individual nanoparticles and electrokinetic enrichment of DNA with a track-etched nanoporous membrane incorporated into a microfluidic device. These experiments took full advantage of the nanoscale size, cylindrical shape and surface properties of the pores in developing unique analytical devices. However, the fabrication of the devices was challenging due to the use of top-down approaches. When I started my own research group at Kansas State University in 2004, I decided to address fundamental issues behind analytical methods using self-organized nanostructured materials that can be obtained with minimum top-down procedures. We investigated the ion permeability of nanoporous films (10– 30 nm in diameter) that were fabricated from polystyrene– poly(methylmethacrylate) diblock copolymers (PS-b-PMMA; the upper-left inset of Figure 1) by photochemical degradation of their cylindrical PMMA microdomains. Cyclic voltammograms for charged and uncharged redox species at different pH values revealed the presence of surface –COOH groups on the native nanopores and verified chemical functionalization of the nanopores via amidation of the –COOH groups. The nanoporous polymer films exhibited excellent size-selective permeability for biomolecules, and also pore size tunability based on solvent-induced swelling of the films. Our electron-hopping studies were inspired by a suggestion given by Prof. Royce Murray (University of North Carolina, Chapel Hill) during his visit to Kansas State University as a seminar speaker in 2009. He encouraged me to quantitatively determine the density of the surface –COOH groups. He suggested electrochemical measurements of cationic redox T. Ito Department of Chemistry Kansas State University 213 CBC Building Manhattan Kansas 66506-0401 (USA) Tel.: (+1) 785-532-1451 Fax: (+1) 785-532-6666 E-mail: email@example.com T H E C H E M I C A L R E C O R D Commentary


We present the system we built for participating in the PAN-2016 Author Profiling Task [9]. The task asked to predict the gender and the age group of a person given several samples of his/her writing, and it was offered for three different languages: English, Spanish, and Dutch. We participated in both subtasks, for all three languages. Our approach focused on extracting genre-agnostic features such as bag-of-words, sentiment and topic derivation, and stylistic features. We then used these features to train SVM-based classifiers, as implemented in LIBLINEAR for the gender classification sub-task, and in LIBSVM for the age classification sub-task.


J'articule très distinctement de manière qu'il puisse lire sur mes lèvres: JE SUIS LA PRIN-CES-SE DE LAM-BAL-LE. JE SUIS LA PRIN-CES-SE DE LAM-BAL-LE. (Modiano 1969, p. 169) This essay is about the relationship between L'Anglaise et le Duc and Triple Agent and the rest of Eric Rohmer's opus. In analysing the tragic and collective dimensions of the two films, it examines how Rohmer constructs in them an uncharacteristically dark view of the world, and it shows how the thematic changes are accompanied by modifications in cinematographic practice. While essentially in accord with those who believe that these films do mark a significant break with Rohmer's other work, it argues that connections can be found both through a critical appraisal of what Pascal Bontizer has described as the 'subterranean horror' of Rohmer's world, and especially through a fresh look at Rohmer's often neglected first feature, Le Signe du Lion.


Limitations in determining the resonance frequency for large models, taking into account non-linearity in the form of contact, initiated work on the creation of a simplified method of estimating these resonance frequencies. The trend in this field is the use of time-domain methods with full contact, or frequency-domain methods which take into account nonlinearity for specific cases. For simplification, classical modal analysis is often used, with boundary conditions taken into account or freeform vibrations, with neglected contact, or with tied contact areas, as though the contact was always closed. The presented approximation method is based on both types of such analysis and compensates for the error of both of the solutions. The method was elaborated with nonlinear dynamics simulations in the time domain. This work presents experimental verification of the method for a simple beam, and for more complex geometry—the satellite antenna panel.


16S rRNA gene clone library construction was used to analyze the microbial communities of soil sampled from above a known Ban876 gas reservoir.Two clone libraries DGS1 and DGS2 were constructed.There were 150 clones from the two libraries respectively for amplified ribosomal DNA restriction analysis(ARDRA).40 Taxanomic operational units(OTUs) were found in library DGS1,and 39 OTUs were found in library DGS2.Sequence analysis of the representative clone of each OTU showed that dominant bacteria of the DGS1 were affiliated with Gemmatimonadetes 28%,Chloroflexi 23%,Actinobacterium 21%;and Chloroflexi 19%,Sulfur-oxidizing 12%,Acidobacteria 10%,Gemmatimonadetes 10% for DGS2,which provides foundation for application of MPOG(Microbial prospecting of oil and gas).


Objective
To explore the interactions mechanism of job embeddedness of nurses with psychological capital, organizational commitment, intention to stay and their influencing factors.

Methods
By convenient sampling method, 722 nurses were investigated with Job Embeddedness Questionnaire, Psychological Capital Questionnaire, Organizational Commitment Questionnaire and Nurses' Intention to Stay Questionnaire.Path analysis was made on relations between the variants.

Results
Night shift intervals pose positive influence on nurses' psychological capital, organizational commitment and intention to stay.Psychological capital can influence job embeddedness by both directly and indirectly, and can influence their intention to stay indirectly.Organizational commitment can influence job embeddedness strongly and directly(r=0.494), and their intention to stay both directly and indirectly.Job embeddedness can influence their intention to stay directly(r=0.453). The model fitting is found desirable.

Conclusions
Nursing managers can enhance nurses' organizational commitment by developing the psychological capital to enhance nurses' organizational commitment effectively.Nurses with higher level of psychological capital and organization commitment will embed into their workplace more deeply, then increasing their intention to stay ultimately.

Key words:
Nurse; Job embeddedness; Psychological capital; Organizational commitment; Intention to stay


In this paper we have performed a systematic review of studies related to the mental states of people engaged in software development, particularly programmers. This review underscores consensus relating to some more thoroughly studied areas, such as the relationship between emotional state and productivity. It also highlights emerging trends such as the use of biosensors, and many areas of limited understanding that might be fruitful topics for the application of new emerging techniques.


ANSWER: Trigeminal neuralgia is a chronic pain syndrome characterized by episodes of electric shocklike, stabbing pain. Irritation of the trigeminal nerve, which branches into the forehead, cheek, and lower jaw, causes excruciating and debilitating pain, typically in the cheek or jaw on one side of the face and occasionally in the area around the nose and eye. (For details, see Getting to the root of trigeminal neuralgia.) Although TN can't be cured, it usually can be managed with medications or surgery. Each year, about 15,000 Americans are diagnosed with TN. The disorder is more common in women than men and rarely affects anyone under age 50. Risk factors for TN include hypertension and multiple sclerosis (MS), but the cause often is unknown.


The paper introduces a fast Monte Carlo method developed for simulation of gamma density measurements. A main advantage of this method is its high performance. For simulation of tool responses, the proposed method is faster than conventional Monte Carlo methods by several orders of magnitude. The demonstrated performance of the proposed method allows its using in analysis and interpretation of measurements obtained in beds with complex geometry.


Unpackaged food is a solution for the growing environmental concerns nowadays. However, since a product package itself communicates a lot of things, the question raised what product benefits can still be communicated when there is no package. Therefore, this study examined to what extent unpackaged food compared to two different types of packages (plastic and paper) have an influence on consumer responses (perceived healthfulness, perceived freshness, product liking and purchase intention). Besides, the influence of the presence of a health label is examined. Consumers' general health interest and environmental interest were included as moderating variables.
The results of the study showed that unpacked foods and paper packages have positive effects on perceived healthfulness, perceived freshness and product liking, as opposed to plastic packages. This study also proved that unpackaged foods are as good as packaged foods in terms of communicating product benefits. However, when it comes to behavioral intentions, more persuasion is needed to stimulate consumers to choose unpackaged food. The presence of a health label did not affect consumer responses. In addition, no evidence was found for interaction effects of the moderating variables.


Eleven soil pedons representing three soil series, commonly mapped as loess over contrasting residuum in southwestern Kentucky, were studied. Numerous tests were conducted to determine which parameters are most reliable in discerning loess from underlying residuum and at the same time to obtain more complete characterization of these soils. Soils studied include the Bedford (Typic Fragiudults), Crider (Typic Paleudalfs), and Zanesville (Typic Fragiudalfs) series. Quartz/feldspar ratios indicate that the three soil series are very similar in the upper horizons, but somewhat different in the lower horizons, and have clear lithologic discontinuities. The occurrence and location of this discontinuity in the soil pedon as determined by the quartz/feldspar parameter agree closely with the pedon morphology described in the field. Particle size distributions indicate that the upper horizons of all the pedons are very similar, particularly in silt content. Particle size distributions also indicate a clear lithologic discontinuity in each of the Bedford and Zanesville soil pedons but do not show a clear boundary for Crider soils. Results from particle size analysis, quartz/feldspar ratios and field observed morphology indicate the presence of a thin loess mantle over differing residuum in these southwestern Kentucky soils.


Brazil is the largest coffee producer in the world and Minas Gerais is the state responsible for 51.14% of this production, corresponding to 1.55 million tons of beans. In this context, contribution from family farming is signifcant. The aim of this work was to use a multivariate statistical methodology to provide plausible and interpretable results to diagnose the most influential body postures for each worker in coffee crops. Twelve workers were observed during a period of one hour in different tasks. Greater variability of body posture was shown during herbicide application on sloping ground. Despite body postural variability among workers during the tasks, some body postures, like 131 and 231, stood out. The proposed methodology allowed to identify the most influential body postures for each worker in an ergonomic point of view, and to aware the workers about the importance of adequate body postures during the tasks of coffee harvesting and post harvesting to avoid health damage.


Working at the intersection of political science and sociology, Claus Offe is one of the most incisive social scientists of his generation. He has a long-standing interest in the structural conditions (and tensions) of capitalist democracies and in the way markets, democracy, and welfare institutions interact. His latest book in German, Europa in der Falle (2016), is a translation of his Europe Entrapped, published in 2014 with Polity Press (Cambridge). The book under review is then a translation of an English-language book into its German author's native language. The book focuses on the question of the European Union's political capacity to act, and the possible pathways out of its paralyzing crisis. Though the book shares some of the pessimism expressed by authors such as Fritz Scharpf and Wolfgang Streeck, when it comes to overcoming the deadlock of European integration in general and the European crisis in particular, Offe still sees a little light at the end of the tunnel. While sharing many of the insights presented in Wolfgang Streeck's widely discussed work, Gekaufte Zeit: Die vertagte Krise des demokratischen Kapitalismus (Suhrkamp 2013; translated into English as, Buying Time: The Delayed Crisis of Democratic Capitalism, Verso 2014), Offe proves to be less pessimistic and does not turn his back on the integration project. Both books, however, highlight the difficult dilemmas faced by social democrats with respect to European integration: a choice between Scylla and Charybdis, between a nationalist and exclusive version of a welfare consensus and a marketized Europe with little capacity to redress inequalities and compensate social risks. The euro crisis has placed even more constraints on countries' abilities to provide welfare and, likewise, on the emergence of a "social dimension" of Europe, which would be essential to any left-wing program. In reflecting on the common market and the euro crisis, Streeck predicts a gloomy future for the Postwar Settlement and foresees the "Hayekization of European capitalism"—in other words, a world of unbridled capitalism offering few possibilities to redress inequalities. As a counter-strategy, he proposes that we should seek to repair what is left of the nation state rather than moving ahead with the integration


Respiratory syncytial virus (RSV) is a major pathogen that can cause acute respiratory infectious diseases of the upper and lower respiratory tract, especially in children, elderly individuals and immunocompromised people. Generally, following viral infection, respiratory epithelial cells secrete cytokines and chemokines to recruit immune cells and initiate innate and/or adaptive immune responses. However, whether chemokines affect viral replication in non-immune cells is rarely clear. In this study, we detect that chemokine CCL5 was highly expressed, while expression of its receptor, CCR1, was downregulated in respiratory epithelial cells after RSV infection. When we overexpressed CCR1 on respiratory epithelial cells in vivo/in vitro, viral load was significantly suppressed, which can be restored by the neutralizing antibody for CCR1. Interestingly, the antiviral effect of CCR1 was not related to type I interferon (IFN-I), apoptosis induction or viral adhesion or entry inhibition; in contrast, it was related to the preferential recruitment and activation of adaptor Gαi, which promoted inositol 1,4,5-triphosphate receptor type 3 (ITPR3) expression, leading to inhibited STAT3 phosphorylation, explicitly, phosphorylated (p)-STAT3 was verified to be among the important factors regulating the activity of HSP90, which has been previously reported to be a chaperone of RSV RNA polymerase. In summary, we are the first to reveal that CCR1 on the surface of non-immune cells regulates RSV replication through a previously unknown mechanism that does not involve IFN-I induction.


Because of their speed, suddenness, and disturbance of the rhythms of everyday life, terrorist attacks are defined by temporal disruptiveness. Hence, a crucial part of what the United States has had to do after September 11th is repair time by constructing linear narratives about terror. Sometimes, visual media have aided in this mission, but this paper explores an instance where a film confounded it. Drawing on insights from visual culture studies, political philosophy, and trauma studies, I analyse the visual dynamics of terror and temporality surrounding Osama bin Laden's September 2007 video, 'The Solution', in which bin Laden appeared to be younger than he was in 2004. Despite clear textual evidence that the video was current, media and state agencies puzzled over its date because its visual content was so incomprehensible. The perplexity that followed revealed America's need to launch temporal strikes against terrorism, and also the difficulty of doing so. In 2010, the FBI offered a rejoinder to 'The Solution': age-progressed images of bin Laden. This virtual, ephemeral victory was the only temporal corrective available at the time; bin Laden's death and, more specifically, burial at sea offered a corporeal, permanent fix to the temporal/visual dilemma he created on 9/11.


In this research, we try to model soot dynamics in a gasoline engine by using measurement data. In prior to the modeling, a problem of input selection is addressed, and Li regularization-based solution is proposed. The constructed soot model will be utilized for further developing and improving transient injection control.


3D Arnold cat map can be applied in image encryption, and it has more security and better effect. However, its period is fixed. The original image will be returned to itself if iterating some times. On the basis of 3D Arnold cat map, it presented an algorithm of image encryption which separates the original image to many same blocks and no period. Simulation analysis shows that the encryption algorithm has characters of strong keys, better effect and fast.


Productive service industry is an important intermediary that reinforces the competitiveness ofmanufacturing and other industries.The accounting,contribution and outer sourcing of productive service industry,the relationships among productive service industry and others concern the national and international academia.The research on the competitiveness of productive service industry on the basis of competitiveness will drive constantly its rapid development.


The midsize single-phase liquid argon prototype detector, operating at the surface laboratory, is designed to measure scintillation light emitted by the liquid argon (LAr). The detector employs 42 8-inch photomultiplier tubes (PMT) to collect the light. By analyzing the waveform of the signal, important detector characteristics such as the slow decay time constant that characterizes the purity of the liquid argon can be obtained. To describe the signal waveform, a model, which takes into account the liquid argon emission decay times together with the TPB re-emission process as well as the signal reflection effects, is used. The TPB re-emission process is introduced using a three-exponential time structure. Additionally, experimental results provide comprehensive validation for a post-peak hump structure, which is attributed to signal reflection.


In order to prevent postoperative functional obstruction, a method of temporary minimal gastrostomy with the use of the round ligament of the liver was developed and tested during surgery on the biliary tract (in 41 patients).


The utility model belongs to the field of illumination devices, and relates to a multifunctional solar street lamp which comprises a lamp post. A lamp hood, a solar panel, a water sprayer and a control panel are arranged on the lamp post, the lamp hood is arranged at the tail end of the lamp post, and the solar panel is arranged between the water sprayer and the control panel. The multifunctional solar street lamp can play the illumination role and also can spray water to the surrounding landscape architecture, a seat is further arranged at the bottom end of the street lamp so that workers and pedestrians can take a rest conveniently, and a water level monitor is arranged at the lower end of the seat to monitor water accumulating conditions anytime and give out alarms.


Abstract Filmmakers begin their work with an empty screen in the same way that artists approach a blank canvas. The implied intention is to create a work that will evoke emotion, thought and reflection. As both film and art have developed, so have the ways in which the screen or canvas is populated. As technology has developed so have methods of transferring the intention. Likewise, there have been adaptations in the way viewers, absorbed in moving images on the screen, interpret the images from moment to moment, ultimately, as a composite work, and from their particular point of view. This article examines certain ethical aspects of watching film with regard to three relevant film innovations, namely: classical Hollywood narrative, modern auteur film, and a comparison between the experience of contemporary viewing, with its access to new technological platforms on the one hand, and viewers' experience of the very earliest film on the other. The discussion incorporates some thoughts on the Greek philosopher Plato's Allegory of The Cave, which is presented in his work The Republic, where he interrogates how reality and knowledge are mediated according to the point of view from which the images projected onto the wall of the cave are viewed and interpreted. With reference to watching images in film, the article proposes three points of viewer interpretation that affect their experience of reality and knowledge which include the ethics of familiarity (routine viewer), the ethics of expectation (customised viewer), and the ethics of the medium (novel viewer).


Caerin 4.1 (GLWQK5IKSAA10GDLAS15GIEVG20IKS-NH2) is an antibiotic peptide isolated from the Australian tree frog Litoria caerulea. Unlike caerin 1.1, the major peptide isolated from this species, caerin 4.1 has a narrow spectrum of antibiotic activity, e.g. it shows selective activity against Pasteurella haemolytica and Escherichia coli. Caerin 4.1 consists of 23 amino acid residues and is comparable in size with other wide-spectrum antibiotic peptides isolated from Australian amphibians, e.g. caerin 1.1 and maculatin 1.1. An n.m.r. study in trifluoroethanol/water indicates that caerin 4.1 forms an amphipathic α-helix with distinct hydrophilic and hydrophobic zones. Two regions of well defined helicity (from Gln4 to Ala10 and from Ile17 to Ile21) are separated by a central helical region of greater conformational variability. The enhanced disorder in this region arises from the presence of two central glycine residues at positions 11 and 16. However, the degree of disorder and hence flexibility is much less than in caerin 1.1 where central proline residues are present instead. This reduced central flexibility may account for the narrow spectrum of biological activity of caerin 4.1, i.e. because biological membranes of the various bacteria have different composition and topology, their optimal interaction with the relatively rigid caerin 4.1 peptide is not possible.


OBJECTIVE
To study the expressions of angiotensin II 1A receptor (AT1A) both at the mRNA level and the protein level and their modulation by an angiotensin converting enzyme inhibitor, benazepril, in the renal tubulointerstitial injuries induced by unilateral ureteral obstruction (UUO) in rats.

METHODS
Six SD rats (UUO-T) were administered benazepril in the drinking water (50mg/L). Additional 6 rats were used as untreated controls (UUO-C). Mean arterial Prossure (MAP) was measured at the 10th day after UUO, and then all animals were sacrificed. The expressions of AT1A were examined both at the mRNA level by in situ hybridization using a subtype-specific probe and at the protein level by an immunohistochemistry methods using AT1 receptor antibody in normal rat kidneys and the obstructed rat kidneys.

RESULTS
MAP was 14.2 +/- 0. 6kPa in the UUO-T and 16.6 +/- 0.7kPa in the UUO-C (P < 0.05). Benazepril slowed the tubulointerstitial fibrosis (TIF) and reduced the expression of AT1A in the renal tubular epithelial cells, the interstitial areas, and the walls of renal arteriole in the UUO-T group.

CONCLUSION
The increased expressions of AT1A were found in the acute renal tubulointerstitial pathogenesis induced by UUO. Benazepril may retard the progression of TIF and decrease the expression of AT1A in the obstructed kidneys. We conclude that the effects of Ang II on the obstructed kidneys may be due to its binding with AT1A.


Alzheimer's is a dementia disease associated with changes in protein in the brain. According to WHO, in 2010 there were 35.6 million people suffering from dementia. People with dementia are usually the elderly. Due to the lack of awareness, information, and knowledge about Alzheimer's disease, an expert system was created using the Dempster-Shafer comparison method with Certainty Factors to assist in early detection of the disease. The results of this study are, there is a final value of the diagnostic results using the Certainty Factor method of 56% while using the Dempster-Shafer method of 54.5%. Keywords: Alzheimer, Expert system, Dempster-Shafer, Certainty Factor, Web-Based.


First of all, I would like to thank Anderson-Cook, Lu, and Parker (ALP) for a very interesting paper highlighting an aspect of the statistics discipline that is critically important but not often d...


In 2013 Roberto Daolio, an important Italian contemporary art critic and curator passed away. His heirs Antonio Pascarella and Stefano Daolio gave his legacy to the MAMbo museum, made of the works of art he had been collecting over 30 years among the artists who crossed his professional (and often affective) career. This text is a brief analysis of the methodologies adopted and the problems encountered while studying his collection, as well as of all the testimonies and documents of its acquisition. The whole study group has had the unique chance of facing the problem of analysis, conservation and exposure of such a particular collection, in order to integrate new aspects in the ways acquisitions are usually studied. Although deeply different in quality, genre, format and support every work of art and every document in the archive had Roberto Daolio as common denominator, a new source of narration of the history of art in our most recent past.


A Finite Volume Method is employed for solving the coupled fluid/structure problem encountered in porous deformable media, namely the flow in the porous rock of a petroleum reservoir coupled with the stress field in the porous matrix. As oil is produced, the porous pressure diminishes changing the porosity of the structure, requiring careful monitoring of the structure of the matrix to avoid rock collapse. This coupled problem is normally solved using two different methodologies, finite volume, or finite-differences, for the flow in the porous media, and finite element for the rock mechanics. The reason for this approach is the belief that finite volume methods are suitable only for fluid flow problems. In fact, the momentum conservation equation is, obviously, the same for both problems, allowing the proposition of a single method, using a single grid for solving the coupled problem. As a consequence, it is not required grid interpolation to transfer results from one problem to another and, even more att...


Password-based Authenticated Key Exchange (PAKE) is an attractive solution for secure authentication and key agreement between two parties over insecure networks by using only a human-memorable password. Introduced by Bellovin, the approach has been receiving much attention from researchers and motivating many follow-up works. In this paper, we introduce a new paradigm of designing PAKE protocols using signcryption scheme. The proposed protocol, called Password-based Signcryption Key Exchange (PSKE), not only formally fulfills all security requirements but also is able to provide outstanding computational efficiency over some patented protocols, which target two-party setting such as EKE, J-PAKE, and SRP. These features make PSKE suitable for remote user authentication in the Internet of Things (IoT) context where remote users need to authenticate to IoT devices before securely retrieving real-time raw data at any time from these devices.


Background: Allogeneic stem cell transplantation (allo SCT) is the only potentially curative therapy for patients with intermediate-2 and high-risk myelofibrosis (MF). Allo SCT for MF has historically been challenging as many patients are transplanted with active or advanced disease and immune reconstitution in MF patients is often hindered by inflammation and bone marrow fibrosis. When compared to non-SCT therapies, MF patients who receive allo SCT achieve long-term survival benefits. However, it comes with an upfront cost of an increased risk of non-relapse mortality in the first year after allo SCT (Gowin K et al, Blood Av 2020). Therefore, there is an unmet need to improve on the early outcomes of transplantation for MF.
 Methods: We reviewed MF patients who underwent myeloablative allo SCT with Orca-T derived from HLA matched donors on NCT01660607 and NCT04013685. Orca-T is an investigational cellular product comprising stem and immune cells that leverages highly purified donor regulatory T cells to control alloreactive immune responses. Single agent GVHD prophylaxis was administered as tacrolimus or sirolimus.
 Results: We present outcomes for 7 MF patients with DIPSS risk of int-1 (n=1), int-2 or higher risk MF (n=6) treated with the Orca-T graft and compared this to 6 MF patients who underwent standard of care (SOC) allo SCT at Stanford, between 2017 - 2021 (Table 1). All patients were high or very high-risk based on MIPSS70 plus score v, 2.0. All patients had 10/10 HLA-matched donors, except 1 of 7 Orca-T patients who had 9/10 HLA-matched donor. All but 1 patient in both, Orca-T and SOC, recipients had prior Jakafi exposure.
 All Orca-T recipients had splenomegaly with spleen size of 16.3 - 23 cm. Engraftment occurred at median of D+13 (range 10-29) and 6 of 7 patients had 100% CD3 donor chimerism at D+100. 1 patient was 90% CD3 donor chimerism at D+100 but achieved 100% CD3 donor chimerism at D+180. All patients had significant marrow fibrosis, MF grade 2 or 3, before allo SCT. Regression of marrow fibrosis to MF grade 0 or 1 was noted by D+ 100 in 7 of 7 Orca-T recipients but only in 1 of 6 SOC patients. Orca-T recipients did not have grade 2-4 acute GVHD and 1 of 7 recipients had extensive chronic GVHD. Tacrolimus was tapered off in 3 of 7 patients at D+180. SOC recipients had 2 of 6 recipients with grade 2-4 acute GVHD, 3 of 6 recipients with extensive chronic GVHD and only 1 recipient was taken off tacrolimus at D+180. There were no deaths in Orca-T recipients and 2 deaths in SOC recipients before D+180, cause of death was acute GVHD and relapse. Finally, when compared to standard allo SCT, Orca-T recipients may have a reduced frequency and severity of infections without significant consequences while the SOC patients had severe and often multiple infections.
 Conclusion: Our data indicates that Orca-T graft was well tolerated and potentially efficacious in MF patients undergoing allo SCT. We observed early regression of marrow fibrosis at D+100 in all Orca-T recipients. This limited data suggests that Orca-T may afford an early resolution of an inflammatory microenvironment that allows for robust immune reconstitution and potentially lower incidence of serious infections. Orca-T is under continued investigation to reduce early non-relapse mortality for MF.
 Figure 1 Figure 1.

 Gandhi: CareDx Inc: Honoraria; Gamida Cell: Consultancy, Membership on an entity's Board of Directors or advisory committees. Muffly: Pfizer, Amgen, Jazz, Medexus, Pfizer: Consultancy; Astellas, Jasper, Adaptive, Baxalta: Research Funding; Adaptive: Honoraria, Other: fees for non-CME/CE services: , Research Funding. Shiraz: Kite Pharma-Gilead: Research Funding. Fernhoff: Orca Bio: Current Employment. McClellan: Orca Bio: Current Employment, Current holder of individual stocks in a privately-held company, Current holder of stock options in a privately-held company. Gotlib: Allakos: Consultancy; Cogent Biosciences: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Chair for the Eligibility and Central Response Review Committee, Research Funding; PharmaEssentia: Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS: Research Funding; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Abbvie: Membership on an entity's Board of Directors or advisory committees, Research Funding; Kartos: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Deciphera: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Blueprint Medicines: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Incyte: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Meyer: Triursus Therapeutics: Current holder of stock options in a privately-held company; GigaImmune: Current holder of stock options in a privately-held company; Orca Biosystems: Research Funding; Indee, Jura: Consultancy.


Due to intermittent connectivity, routing protocols in opportunistic mobile social networks (OMSN) forward messages through opportunistic contacts. Previous opportunistic routing protocols focus on the past contact history of nodes to make a forwarding decision. It was found that predicting temporally evolving contacts and communities according to different times of the day would improve the accuracy of the prediction. In this paper, a routing paradigm called RRoutine is proposed that allows message holders to exchange multiple copies of the message based on the predicted number of communities. This distribution continues until the remaining copies of the message become one. Each message holder applies either inter or intra‐community forwarding and selects a set of potential forwarders based on the prediction of future encounters in the community and an expected remaining duration between two nodes (ERIMD). The estimation of ERIMD takes into account the sequence of daily activities, the time scale of current activities, and the return time to regular meetings of the nodes. Also, unlike traditional routing, where a single forwarder is selected, a set of potential candidates is selected and prioritized according to their contact prediction, with the most likely candidate receiving the highest priority. Simulation results obtained from synthetic and real mobility data show that the proposed paper improves the performance of the system in terms of message delivery rate, throughput, and latency.


Introduction, D.D. Lasic and F.J. Martin Foreword, A.D. Bangham Stealth(R) Liposomes: From Steric Stabilization to Targeting, D. Papahadjopoulos Fate of Liposomes In Vivo and Its Control: An Historical Perspective, G. Gregoriadis Effect of Surface Modification with Glycolipids and Polysaccharides on In Vivo Fate of Liposomes, P.C. Ghosh and B.K. Bachhawat Stabilization of Colloidal Dispersions by Grafted Polymers, O. Borisov, P. Auroy, and L. Auvray Physical Properties of Polymer-Grafted Bilayers, K. Hristova and D. Needham Molecular Mechanism of Liposome and Immunoliposome Steric Protection with Poly (Ethylene Glycol): Theoretical and Experimental Proofs of the Role of Polymer Chain Flexibility, V.P. Torchilin, M.I. Papisov, A.A. Bogdanov, V.S. Trubetskoy, and V.G. Omelyanenko Measurement of the Range and Magnitude of the Repulsive Pressure between PEG-Coated Liposomes, T.J. McIntosh, A.K. Kenworthy, and D. Needham Modulation and Modeling of Interaction Forces between Lipid Bilayers Exposing Terminally Grafted Polymer Chains, T.L. Kuhl, D.E. Leckband, D.D. Lasic, and J.N. Israelachvili Polyetheylene Glycol-Lipid Conjugates, S. Zalipsky Biological Properties of Sterically Stabilized Liposomes, M.C. Woodle, M.S. Newman, and P.K. Working Mechanism of Stealth(R) Liposomes Accumulation in Some Pathological Tissues, S.K. Huang, F.J. Martin, D.S. Friend, and D. Papahadjopoulos Extravasation of Stealth(R) Liposomes into Tumors: Direct Measurement of Accumulation and Vascular Permeability Using a Skin-Flap Window Chamber, M. Dewhirst and D. Needham Pharmacokinetics and Antitumor Activity of Anthracyclines Precipitated in Sterically Stabilized (Stealth(R)) Liposomes, D.D. Lasic Tissue Uptake and Therapeutic Effects of Stealth(R) Doxorubicin, J. Vaage and E. Barbera Therapeutic Application of Vincristine in Conventional and Sterically Stabilized Liposomes, P.S. Uster Stealth(R) Liposomes as a Drug Sustained Release System for 1-b-D-Arabinosylfuranosylcytosine (Cytosine Arabinoside), T.M. Allen Stealth(R) Liposomes as Carriers of Antibiotics in Infectious Diseases, I. Bakker-Woudenberg, G. Storm, and M.C. Woodle Sterically Stabilized Liposome-Encapsulated Hemoglobin, S. Zheng, Y. Zheng, and R. Beissinger PEG-Modified Liposomes for Gamma-II and Magnetic Resonance Imaging, V.P. Torchilin, J. Narula, B.A. Khaw, and V.S. Trubetskoy Antibody-Targeted Stealth(R) Liposomes, T.M. Allen, C.B. Hansen, and S. Zalipsky Doxorubicin Encapsulated in Polyethylene-Glycol Coated Liposomes: Initial Clinical-Pharmacokinetic Studies in Solid Tumors, A. Gabizon, A. Huang, F. Martin, and Y. Barenholz Pharmacokinetics and Tumor Localization of DOX-SL (Stealth(R) Liposomal Doxorubicin) by Comparison with Adriamycin in Patients with AIDS and Kaposi Sarcoma, D. Northfelt, L. Kaplan, J. Russell, and P. Volberding Efficacy of DOX-SL (Stealth(R) Liposomal Doxorubicin) in the Treatment of Advanced AIDS-Related Kaposi Sarcoma, J.R. Bogner and F.D. Goebel


This paper explains the semantic translation and communicative translation put forward by Peter Newmark,and analyzes the translation strategies adopted by Anthony C.Yu and W.J.F.Jenner in translating Buddhism Elements in Journey to the West,aiming to compare the different effects in cultural transfer.The author holds that semantic translation adopted by Anthony C.Yu is more efficient when he expected to spread Chinese culture,however,W.J.F.Jenner preferred to practice communicative translation for his intention is to make the translation more readable for western readers.


Original Research Paper Received 31 May 2015 Accepted 19 June 2015 Available Online 13 July 2015 In this study, novel robust impedance control for lower-limb rehabilitation robotic system using voltage control strategy is used. Most existing control approaches are based on control torque strategy, which requires knowledge of robot dynamics as well as dynamics of patients. This obliges the controller to overcome complex problems such as uncertainty and nonlinearity involved in the dynamics of the system, robot and patients. Conversely, the voltage-based control approaches are free from the system dynamics. In addition, it considers the actuator dynamics. The performance of voltage-based approaches is demonstrated by experimental result in robotic applications. Compared with torque control scheme, it is simpler, less computational and more efficient. Nevertheless, uncertainty of actuator dynamics results in challenges for the voltage control strategy applications. The present paper presents novel robust impedance control based on the voltage control strategy. To overcome uncertainties, the adaptive fuzzy estimator is designed based on the voltage-based strategy. The proposed control is verified by stability analysis. To illustrate the effectiveness of the control approach, 1-DOF lower-limb rehabilitation robot is designed. Both torque-based impedance control and the voltage-based impedance control are compared through therapeutic exercise. It is shown that the voltage-based impedance control performs better than the traditional torque-based impedance control. Simulation and experimental results both show that the proposed voltage-based robust impedance control is superior to voltage-based impedance control in presence of uncertainties.


In 2012 the Australian Commonwealth government was scheduled to release the first dedicated policy for culture and the arts since the Keating government's Creative Nation (1994). Investing in a Creative Australia was to appear after a lengthy period of consultation between the Commonwealth government and all interested cultural sectors and organisations. When it eventuates, the policy will be of particular interest to those information professionals working in the GLAM environment. GLAM is a cross-institutional field which seeks to find points of commonality among various cultural heritage institutions, while still recognizing their points of difference. Digitisation, collaboration and convergence are key themes and characteristics of the GLAM sector and its associated theoretical discipline. The GLAM movement has seen many institutions seeking to work together and create networks of practice, which are beneficial to the cultural heritage industry and sector. With a new Australian cultural policy imminent, it is timely to reflect on the issues and challenges the GLAM principles present to national cultural heritage institutions by discussing their current practices. In doing so, it is possible to suggest productive ways forward for these institutions which could then be supported at a policy level by the Commonwealth government. Specifically, this paper examines four institutions: the National Gallery of Australia, the National Library of Australia, the National Archives of Australia and the National Museum of Australia. The paper reflects on their responses to the Commonwealth's Cultural Policy Discussion Paper (2011). It argues, that by encouraging and supporting collecting institutions to participate more fully in GLAM practices, the Commonwealth government's cultural policy would enable far greater public access to, and, participation in, Australia's cultural heritage. Furthermore, by considering these four institutions, the paper presents a discussion of the challenges and the opportunities that GLAM theoretical and disciplinary principles present to the cultural heritage sector. Implications for Best Practice  GLAM is a developing field of theory and practice that encompasses many issues and challenges for practitioners in this area  GLAM principles and practices are increasingly influencing the cultural heritage sector  Cultural policy is a key element in shaping the future of Australia's cultural heritage sector and needs to incorporate GLAM principles


This paper examines the interface issues which occur when pulse width modulated (PWM) voltage source power converters (VSCs) are connected to the utility. In particular, it investigates the line current total harmonic distortion (THD) characteristics of various current regulated PWM (CRPWM) techniques with constraints on the power converter average switching frequency (power converter efficiency) and passive filter size (filter cost). Various CRPWM methods with proper filter and controller structures have been studied and evaluated by means of computer simulations for the utility interface with a variable speed wind turbine generating system. Dynamic performance has been evaluated as well as the steady state light load, full load, leading, lagging and unity power factor operating conditions.<<ETX>>


Natural hazards may have severe impacts on the performance of transportation systems. Although a natural hazard is usually spatially local, its impact, through the network of transportation systems, could become global. This paper is particularly concerned with how to quantitatively assess the vulnerability of a network system by taking into account indirect impact of spatially local hazards. To this end, this paper firstly defines a neutral line and impact curve. Then, based on neutral line and impact curve, two novel spatial vulnerability indexes are proposed: absolute spatial vulnerability index (ASVI) and relative spatial vulnerability index (RSVI). Both ASVI and RSVI can effectively indicate to what extent a network system is vulnerable/neutral/robust to spatially local hazards. The proposed spatial vulnerability indexes are then particularly applied to study the civil aviation network system in China, and the simulation results show that (i) the new concept is correct and useful, and (ii) the Chinese civil aviation network system is vulnerable to spatially local hazards when indirect impact is considered.


The author speeks about the concept of Jus that consequently brings us the yearned justice. Within this parameter, Law's envolvement itself, creator of the Jus , understood as the entirety of positive rules, establishing, thus, the social and political life of civitas .


In the magnetically controlled Plasma-GMAW welding process, the composite arc forms a keyhole in the workpiece to be welded. In order to explore the effect of process parameters on arc coupling, weld pool and keyhole, and the behavior characteristics of keyhole, the arc behavior and side weld pool information were collected using a welding arc acquisition system and a high-speed camera during bead-on-plate welding. The arc image is processed by pseudo-color enhancement technology, and the collected molten pool information is analyzed by boundary extraction algorithm and coordinate conversion algorithm, and the molten pool boundary and keyhole entrance width are obtained. It is found that the coupling degree of the two arcs increases with the increase in plasma current, GMAW current and magnetic field intensity. With the increase in plasma current, the size of keyhole inlet increases; with the increase of GMAW current, the size of keyhole inlet decreases, and the wave crest increases. With the increase of magnetic field intensity, the intensity of metal oscillation between the two arcs increases, and so does the wave crest.


This is a single‐institution prospective study in a tertiary care center to evaluate feasibility, completeness of resection, and functional outcomes for oropharyngeal squamous cell carcinoma (SCC) treated primarily with transoral robotic‐assisted resection.


A few distributions are compared, at the NLO accuracy, between signal and background for the production process of a Higgs in association with 2 top quarks at the LHC. Furthermore, the impact of a jet veto on the NLO corrections is studied. The tt̄H → tt̄bb̄ signal and the QCD tt̄bb̄ background are computed exactly in the framework of the HELAC-NLO system.


A Cyprinid herpesvirus 2 (CyHV-2) strain YZ01 was isolated from an apparently healthy goldfish with history of exposure to CyHV-2 when the water temperature was heated from 3-6□ to 25□. Brain, kidney, spleen (referred to as BKS) and intestine of sick and dead fish as well as crucian carp (CrCB) or goldfish brain cell (GFB) suspensions inoculated with above tissue homogenate were collected for PCR assay.Infected cell layers were prepared into ultrathin sections for transmission electron microscopy. Virus DNA were purified from cell suspensions for whole genome sequencing and analysis. Intestine and mixed brain, kidney and spleen fluid (BKS) of dead goldfish and BKS-infected CrCB suspensions as well as their subsequent passages were tested positive by PCR. Nucleus deformation, lattice-like arrangement of inclusion bodies and various forms of immature and mature virions in the nucleus, cytoplasm and outside of cell membranes were observed. Whole genome analysis of 7 CyHV-2 strains available in GeneBank showed that all strains' genomes share very high homology while YZ01 was more close to CyHV-2 CNDF-TB2015 and SY-C1 which are classified as C genotype.


In a screen for temperature‐sensitive mutants of Saccharomyces cerevisiae defective for mRNA export, we previously identified the essential DEAD‐box protein Dbp5p/Rat8p and the nucleoporin Rat7p/Nup159p. Both are essential for mRNA export. Here we report that Dbp5p and Rat7p interact through their Nterminal domains. Deletion of this portion of Rat7p (Rat7pΔN) results in strong defects in mRNA export and eliminates association of Dbp5p with nuclear pores. Overexpression of Dbp5p completely suppressed the growth and mRNA export defects of rat7ΔN cells and resulted in weaker suppression in cells carrying rat7‐1 or the rss1‐37 allele of GLE1. Dbp5p interacts with Gle1p independently of the N‐terminus of Dbp5p. Dbp5p shuttles between nucleus and cytoplasm in an Xpo1p‐dependent manner. It accumulates in nuclei of xpo1‐1 cells and in cells with mutations affecting Mex67p (mex67‐5), Gsp1p (Ran) or Ran effectors. Overexpression of Dbp5p prevents nuclear accumulation of mRNA in xpo1‐1 cells, but does not restore growth, suggesting that the RNA export defect of xpo1‐1 cells may be indirect. In a screen for high‐copy suppressors of the rat8‐2 allele of DBP5, we identified YMR255w, now called GFD1. Gfd1p is not essential, interacts with Gle1p and Rip1p/Nup42p, and is found in the cytoplasm and at the nuclear rim.


A neural network mechanism is proposed to modify the gait of a biped robot that walks on sloping surfaces using sensory inputs. The robot climbs a sloping surface from a level surface with no priori knowledge of the inclination of the surface. By training the neural network while the robot is walking, the robot adjusts its gait and finally forms a gait that is as stable as when it walks on the level surface. The neural network is trained by a reinforcement learning mechanism while proportional and integral (PI) control is used for position control of the robot joints. Experiments of static and pseudo dynamic learning are performed to show the validity of the proposed reinforcement learning mechanism.  1997 John Wiley & Sons, Inc.


As the society and the heritage business developing rapidly,a great quantity of excellent traditional cultural achievements are being brought to the notice of the protection of cultural heritage.By means of analyzing The List of State Intangible Cultural Heritage systematically and searching for the intrinsic demand of this list,this essay mainly focuses on the advantage and disadvantage of the Yi ethnic minority medicine as a kind of intangible cultural heritage,and discusses the possibility to realize the dynamic transmission and protection of Yi ethnic minority medicine as a intangible cultural heritage.


Graft versus host disease (GvHD) is the most common adverse event after allogeneic bone marrow transplant (BMT). GvHD and the immunosuppression required to treat it limit the desired graft versus leukemic effect and are associated with significant morbidity and mortality. A treatment that selectively controls the harmful immune response during GvHD, without compromising the response to pathogens or tumors, would be transformative. Previously, we demonstrated that mice deficient in Drak2 (Drak2−/−) are resistant to disease in multiple models of T cell-mediated autoimmunity but maintain effective responses to pathogens and tumors. Since similar immune pathologies mediate GvHD and autoimmunity, we sought to investigate whether loss of Drak2 reduced GvHD, while maintaining effective immunity to pathogens. Thus, we utilized a murine model of acute GvHD (aGvHD) in which lethally irradiated mice received MHC-mismatched bone marrow and purified T cells that were either Drak2+/+ or Drak2−/−. We found that mice given MHC-mismatched bone marrow along with Drak2−/− T cells had less severe aGvHD compared to mice receiving Drak2+/+ T cells, as demonstrated by lower clinical scores. Interestingly, mice given Drak2−/− T cells along with MHC-mismatched bone marrow had increased proportions of regulatory T cells and decreased effector T cells compared to mice given wildtype T cells. These data suggest that Drak2 expression within T cells contributes to GvHD development, and therefore is a promising target in the treatment of GvHD. Ongoing studies are investigating whether the absence of Drak2 influences the effective repopulation of a functional immune system following BMT.
 Funding provided by ALSAC and the St. Jude Graduate School of Biomedial Sciences


This study was conducted to develop actual policy alternatives for activating youth mentoring and a 10-member youth mentoring specialist group composed of specialists from various fields was formed to proceed more effectively. The research team first shared the consciousness of the problem with youth mentoring and policy alternatives - which were based on the policy alternatives developed in 2010. Policy alternatives in 8 areas, were finally proposed and developed through exploring the concreting processes of new policy alternatives. Although Korea has been pushing forward with various kinds of mentoring projects for multi-cultural youth, north-defecting youth, youth from low-income families, and delinquent youth - initiated by various government organizations including the Ministry of Education Science and Technology, the Ministry of Health and Welfare, the Ministry of Gender Equality & Family, the Ministry of Law and the Ministry of Employment and Labor, those projects are sporadic and not systematic at this moment. In the U.S.A., the mentoring support system is systematically established, and innovative programs regarding youth mentoring have been experimentally operated. Some of them includee-mentoring, peer mentoring, group mentoring, team mentoring, alternative delivery type and structure, tailored service for specific population and cultural group such as children of lawbreakers, etc. The state government of Victoria, Australia supported US $2.5mil. for the plan of establishing mentoring capabilities to support youth mentoring for 3 years from 2005 and for 4 years from 2008-2009 to 2011-2012, the state government plans to provide US $3.9 mil. for education, employment and training. For the activation of a Korean youth mentoring program, the following policy tasks must be performed: ㆍ the establishment and operation of an integrated, cooperative youth mentoring support center, ㆍ establishment of superior mentors and specialized manpower fostering, ㆍ introduction of a creative youth mentoring incentive system, ㆍ support in establishing the youth mentoring area and program system, ㆍ execution of a youth mentoring participation registration system to enhance social credibility, ㆍ the establishment of an e-monitoring system of youth mentoring, ㆍ the development of an evaluation index, ㆍ the establishment of a social support network in the areas of study, career path, leisure activities, emotions, psychology, administration, financial systems, ㆍ the improvement of laws and regulations related to youth mentoring.


Objective  Radical resection of tumours of the distal rectum has generally entailed an abdominoperineal excision, but the recognition of shorter safe distal resection margins, neoadjuvant chemoradiotherapy and the application of the technique of intersphincteric resection (ISR) have led to the prospect of restorative surgery for patients with distally situated tumours. The present study examines the indications, techniques and outcomes following ISR.


A modern power system is a complex network of interconnected components, such as generators, transmission lines, and distribution subsystems, that are designed to provide electricity to consumers in an efficient and reliable manner [...]


Community structure plays an important role on the analysis of real-world (biological, social, neural) networks. The observation on realistic organizations shows that communities often exhibit hierarchical and overlapping structures. Here, applying a primary DeGroot model in opinion dynamics to the network, we study the divergence of the agents' opinions in the progress of reaching consensus and then propose a robust and efficient framework of synchronization to detect hierarchical and overlapping communities. The proposed framework and obtained results suggest a set of "functional definitions" of the hierarchy and overlapping in modular structures, among which the interpretation and necessity of highly overlapping is firstly reported, shedding a light on the study of the complexity of modular networks.


The purpose of this research was to provide the artificial heart design information necessary for the proper development of an implantable nuclear power supply for the artificial heart. A Kwan-Gett hemispherical artificial heart made of silicone rubber was attached to a mock circulation instrumented with pressure, volume and flow transducers and measurements made of power input to the artificial heart at various locations, source of power losses and efficiencies of the artificial heart under a variety of pumping conditions, volumetric efficiency, pressure required to move the diaphragm of the artificial heart, required motion of the heart diaphragm and pumping characteristics of the artificial heart. The in vitro measurements have been verified by in vivo experiments in calves. The preliminary design of a pumping chamber for the nuclear powered heart has been completed.


To the Editor:— The industrial picture in Britain has lately been holding my attention because it is the nation whose experience with compulsory health insurance that has been presented as most worthy of being copied. Prior to the rearmament activity, Britain's unemployed were listed as approximating 2,000,000. In spite of the war's effect on employment it is said to have been 100,000 more in December 1939 than in the preceding September. Up to the time of the initiation of rearmament the recipients of the dole were estimated to be in the neighborhood of from 16 to 18 million. How are the figures relative to the unemployed to be correlated with those on the dole? Half of Britain's working population receives less than £250 ($1,250) annually. These and their dependents—again, a matter of 18 million—are the beneficiaries of her National Health Insurance. What relation have their numbers to the unemployed or to those on the dole? If the figures for those on the dole do not represent the same fraction of the population as the employed group with incomes less than £250, how, then, are their health needs met? Are they the "charity" of the profession or, if not, in what manner do they provide or is compensation provided for the physician?


Houston - Imagine extracting cells from behind the ear, cultivating them, and then injecting patients with their own fibroblasts, which, over time, stimulate production of new collagen in treated areas. Is such a treatment for wrinkles and other cosmetic problems an elegant solution to an age-old problem or a flight of fancy better suited to science fiction? Proponents of the therapy, developed by Isolagen Inc., say its use of patients' own cells eliminates allergic reactions while providing corrections that can last for many years. However, skeptics express concern that while surgery-free facelift sounds exciting on paper, it ultimately will prove too impractical to administer.


Objective To explore the cleaning method of auricular tube by acid electrical potentia water or alcohol.Methods The surface of tube were besmeared ten times by isotonic Na chlorid,area was 4 cm×4 cm.The auricular tube cleaning putted in asepsis cuvette for bacterial culture.Results To make a compare of two cleanse effect.Conclusion The cleaning effect of auricular tube by acid electrical potentia wate surpassed by alcohol,It have statistical significance(P0.05).


Brighton hardcore act HOWLS have unveiled a new music video for their new song 'Small Talk', coming from their newly released album The Headache, ...


This study investigates factors that influence the use of information and communication technology (ICT) tools by academicians to promote higher order thinking skills (HOTS) among university mathematics students. The study adapted constructs such as performance expectancy, effort expectancy and facilitating conditions from the Unified Theory of Acceptance and Use of Technology. The study applied descriptive research design and used quantitative and qualitative approach in the form of questionnaire and interview to gather data from 86 academicians from three local public universities in Malaysia. The data were analysed in terms of descriptive analysis and content analysis. The result showed that the technology, instructor, student, learning material, task and organisational factors play important roles in promoting HOTS among students. The study contributed to expanding readers' understanding of the factors that influence the use of ICT tools by academicians to promote HOTS among university students.


A field experiment was conducted at Agronomic Research Area, University of Agriculture, Faisalabad during kharif season 2013. The experiment was laid out in a randomized complete block design (RCBD) with factorial arrangement replicated thrice to assess the performance of six rice varieties (V1 = Arize H-64, V2 = Arize Swift, V3 = Basmati 515, V4= Basmati Super, V5 = KSK 133, V6= IRRI 6) at two fertilizer levels {F1 = NPK 150–88– 58 kg ha (recommended for Basmati rice) and F2 = NPK 175–100–78 kg ha -1 (recommended for coarse rice)}. All the dose of phosphorus and potassium were applied as a basal dose and nitrogen were applied in three split doses. The results revealed that variety V1 recorded significantly higher grain; straw and biological yield between hybrids and fertilizer level F2 gave significantly higher all types of yield in this rice type. In basmati types there was no significant increase in yield and yield parameters both at fertilizer and variety stage. In case of coarse rice KSK-133 gave the significantly higher grain, straw and biological yield at F2 level but there was no significant effect of variety. In case of economics the maximum profit (78443) and marginal rate of return (2.12) was obtained from V1 at F2 level. The same variety gave highest profit (69550) and marginal rate of return (2.06) at F1. After that maximum profit (67828) and marginal rate of return (1.98) was obtained from V2 at F2.The basmati 515 gave the highest profit (48951) and marginal rate of return (1.83) at fertilizer level F1 after the hybrids. The variety IRRI-6 gave the minimum profit (27769) and marginal rate of return (1.46) at F2 from all the varieties. Arize H-64 recorded significantly higher radiation use efficiency at F2 as compared to F1. Basmati varieties were not different significantly in RUE at any fertilizer level. In coarse rice F2 gave significantly higher RUE as compared to F1.


Staphylococcus aureus is an opportunistic pathogen very often multidrugresistant that not only causes a variety of human diseases, but also is able to survive on biotic and abiotic surfaces through biofilm communities. The best way to inhibit biofilm establishment is preventing cell adhesion. In the present study, subinhibitory concentrations of the bacteriocins bovicin HC5 and nisin were tested for their capability to interfere with the adhesion of S. aureus to polystyrene. Subinhibitory dosages of the bacteriocins reduced cell adhesion probably due to changes in the hydrophobicity of the bacterial cell and polystyrene surfaces. The surfaces became more hydrophilic and the free energy of adhesion ( ∆Gadhesion) between bacteria and polystyrene surface was unfavorable after treatment with bovicin HC5 and nisin. The transcript level of selected genes was assessed by RT-qPCR approach, revealing that the bacteriocins affected the expression of some important biofilm associated genes ( icaD, fnbA, and clfB) and also rnaIII, involved in the quorum sensing mechanism. The conditioning of food-contact surfaces with bacteriocins can be an innovative and powerful strategy to prevent biofilm in the food industry. The results are relevant for food safety as they indicate that bovicin HC5 and nisin can inhibit bacterial adhesion and consequently biofilm establishment, since cell adhesion precedes biofilm formation. Key-words: Food-contact surface, hydrophobicity, foodborne pathogen.


Summarizes the differences between what adults perceive as sensitive issues affecting children′s well‐being and what children perceive as sensitive issues. Describes how children′s literature can be used to help children develop language to describe their feelings. Explains how different stories can make it possible to explore characters′ feelings and our own feelings, and how they can be used as starting‐points for talking to children about sensitive situations, feelings and relationships.