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Beth2010 needed a new other design and created a contest on 99designs.
A winner was selected from 12 designs submitted by 6 freelance designers.
Premiere http://www.premieresystems.com
Premiere is a uniquely professional, high-end, custom home technology provider. Clients (home owners) hire us because they trust us, based on our: client testimonials, experience, demonstrations. Our refined process, well engineered designs, detailed drawings and experienced project manager and installation team deliver robust and reliable solutions that are sophisticated, yet easy to use.
(Note: We do not have retail store, but rather a business office with demonstration areas. Most prospects come to our office and then visit one of our clients' homes. Architects and designers frequently recommend us.)
New home owners (>$1.5M) who plan to build, renovate, or add home technology. Our clients want intelligent, custom, future-proof home automation design and system implementation. Clients value fine products, our meticulous process, award-winning software, and detailed documentation, and appreciate working with our experienced project managers and technicians. Our clients expect and we deliver excellent solutions, and we offer post-installation system maitenance.
Use creativity with image and create compelling message on a two-sided over-sized postcard (8.5" x 5.47"). Objective is to urge the recepient to call us. Communicate sophistication and experience. Option to use glossy photo stock on one or both sides. Need to reserve address area on back right side of postcard. Use Premiere logo (in attachments).
Use this text somewhere: Call us when you have reached the point you want the professionals to help!
Solutions include: music throughout your home, distributed video, motorized window treatments, lighting control, climate control, computer networks, gaming, surveillance, security, home theater/media rooms.
Premiere... providing custom home technology solutions and pleasing the most discerning clients for over 15 years.
This postcard will be selectively mailed to new home owners. Include address: 1400 N. Kingsbury, Chicago, IL 60642 and telephone number: 312.274.0220.


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Photos On Canvas
ZaZa Gallery's Museum Grade, Archival Canvas
Did you know: Not all canvas is equal.
ZaZa Gallery has always focused on providing canvas prints of only the highest quality. No detail goes overlooked which is why we're proud that we produce our prints on museum grade OBA free canvas with archival ink and coated with a UV protecting finish. We want you to be our client and not our customer, which is why all prints are Museum Grade Quality, designed to last well over 100+ Years.
Because we refuse to use canvas with Optical Brightening Agents (OBA), all of our canvas is acid free. It's common for cheaper canvas to include OBA additives to artificially enhance colors & white tones which later discolor and yellow as the canvas is exposed to UV light (a sign which indicates the canvas has started the process of degradation).
If you'd like to find out if a canvas you have contains OBA additives: simply pass a black light over the canvas, If the whites in the canvas lights up and glows fluorescent (similar to a white t-shirts under a black light), the canvas contains OBA additives. If the canvas doesn't clearly glow, it doesn't contain these OBA additives which reduce the canvas' life.
We're proud to bring you the highest quality product built to last a lifetime.
Canvas Print Info
The production of your picture on canvas starts with the finest materials the industry has to offer. The stretcher bar we use is 3/4 of an inch thick (1 1/2 inch optional). The canvas we use has a mild texture similar to that used by the dutch masters for portraiture. Our canvas and our inks are rated as archival. From the canvas to the ink all the way down to the sealer, we use only museum-quality products.
The end result is a beautiful canvas print with a life expectancy of 100 years under reasonable conditions.

subset: commoncrawl


text: Job Discussion Forums :: View topic - INFO ABOUT CHILE PLEASE Get TEFL Certified & Start Your Adventure Today! Job Discussion Forums"The Internet's Meeting Place for ESL/EFL Students and Teachers from Around the World!" FAQ Search Memberlist Usergroups Register Profile Log in to check your private messages Log in INFO ABOUT CHILE PLEASE Job Discussion Forums Forum Index -> Chile View previous topic :: View next topic Author Message NoubieJoined: 09 Nov 2004Posts: 1 Posted: Wed Nov 10, 2004 2:25 pm Post subject: INFO ABOUT CHILE PLEASE Hello! [b]I want to teach English in Chile! Just wondering if anyone has information on the average salaries, cost of living, best/worst places to work, etc. I would really appreciate that info! Thanks,[/b] Amanda Noubarian Back to top Dennis ParishJoined: 09 Nov 2004Posts: 18Location: santiago de chile Posted: Tue Nov 16, 2004 6:25 pm Post subject: I've been here 3-1/2 years and I can tell you it's a jungle! Your questions are a bit general but I'll try to help. Best/worst places to teach: What are you looking for? Are you certified? the general consensus on worst is Sam Marsalli, who recruit by internet because no one already here would work for them on a bet! There is no best, per se, but some pay a liveable wage while others don't. i can tell you that almost no one will respond to e-mails. Cost of living: relatively high - no bargains here, no living on peanuts. People tend to share housing and there are ads scattered in the gringo hangouts. Average salaries: you shouldn't take less than 5000 pesos/hr but a lot of schools will try and slip by on 3000. On top of that, they'll almost all deduct 10% of this, as required by law, for taxes. You can get that back the next year, usually. feel free to ask whatever else and I'll try to help Back to top Display posts from previous: All Posts1 Day7 Days2 Weeks1 Month3 Months6 Months1 Year Oldest FirstNewest First Job Discussion Forums Forum Index -> Chile All times are GMT Page 1 of 1 Jump to: Select a forum Where to Begin----------------General DiscussionNewbie ForumCurrent Events ForumTechnology ForumOnline Teaching Forum Africa Forums----------------General Africa Forum Asia Forums----------------CambodiaChina (Job-related Posts Only)China (Off-Topic)Hong KongIndiaIndonesiaJapanMalaysiaPhilippinesSingaporeTaiwanThailandGeneral Asia ForumVietnam Caribbean Forums----------------General Caribbean Forum Europe Forums----------------Czech RepublicFranceGermanyGreeceItalyMacedonia and the BalkansPolandRomaniaRussia & C.I.S.SpainTurkeyUkraineUnited KingdomGeneral Europe Forum Latin America Forums----------------ArgentinaBrazilChileColombiaCosta RicaMexicoMexico (off-topic)PeruGeneral Latin America Forum The Middle East Forums----------------BahrainEgyptIsraelKuwaitOmanQatarSaudi ArabiaUnited Arab EmiratesGeneral Middle East Forum North America Forums----------------General North America Forum Oceania----------------Australia/New Zealand You cannot post new topics in this forumYou cannot reply to topics in this forumYou cannot edit your posts in this forumYou cannot delete your posts in this forumYou cannot vote in polls in this forum This page is maintained by the one and only Dave Sperling. Contact Dave's ESL Cafe Copyright © 2018 Dave Sperling. All Rights Reserved. Powered by phpBB © 2001, 2002 phpBB Group Teaching Jobs in China


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Cretacolor Aqua MonolithWoodless WatercolorPencil Sets
Dynasty FauxCamel WatercolorBrushes
BlickFrenchEasel byJullian
BlickWater-SolubleBlock PrintingInks
BlickPencil Case
UtrechtColor WheelGuide
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Professional colors contain finest pure pigments, milled in alkali-refined linseed oil. High chroma, superior tint strength, excellent adhesion, light-fastness, and archival permanence.
Color Swatches created using heavy application/medium application/50% tint and were applied on acrylic primed canvas (7 oz) material.
beta copper phthalocyanine
Phthalo Blue PB15:3 is a structural variant of Phthalo Blue PB15 that produces more greenish tones.
Phthalo Blues are completely lightfast and stable and are permanent for all paint uses. They are currently used in inks, coatings, and many plastics due to their stability and are considered a standard pigment in printing ink and the packaging industry.
Phthalo Blues have no significant hazards, although those made before 1982 contained some PCBs (polychlorinated biphenyls).
Developed by chemists using the trade name Monastral Blue, the organic blue dyestuff now known as Phthalo Blue was presented as a pigment in November 1935 in London. Its discovery was accidental. The dark color was observed in a kettle where a dye was being made from a British dyestuff plant. The demand for such a pigment came from commercial printers who wanted a cyan to replace Prussian Blue.
Phthalo Blue Green Shade, Winsor Blue Green Shade
titanium dioxide
Titanium White is the most brilliant of the white pigments. It is considered an all purpose oil color useful in all techniques and the best all around white. Its masstone is neither warm nor cool, placing it somewhere between Lead White and Zinc White. It is less prone to cracking and yellowing than Lead White, but it still yellows easily. Titanium White dries slowly in oil form, more slowly than Lead White but more quickly than Zinc White. It is opaque in oil and acrylic forms and semi-opaque in watercolor form. This pigment has good chemical stability, and its tinting strength is superior to both Lead White and Zinc White.
Titanium White has excellent permanence and lightfastness.
Titanium dioxide is highly stable and is regarded as completely non-toxic. Animal studies give no indiciation that it is absorbed biologically, even after long periods of exposure. The primary safety concern is with inhalation of fine pigment dust particles. Titanium White, if inhaled in large amounts over the course of several years, may cause a benign pneumoconiosis that is visible on x-rays. The National Institute of Occupational Safety and Health (NIOSH) considers fine titanium dioxide particles, if inhaled, to be a human carcinogen. The primary concern for artists is to avoid exposure to fine particulate dust from raw pigments.
Titanium is the ninth most abundant element in the Earth's crust, however mineral deposits that are economical to mine are less common. Titanium dioxide was first discovered in 1821, although it could not be mass produced until 1919. Widespread use of the pigment began in the 1940s. Since that time, it has become the most commonly used white pigment. The name comes from the Latin word Titan, the name for the elder brother of Kronos and ancestor of the Titans, and from the Greek word tito, meaning day or sun.
chromium(III)-oxide dehydrate
Cr2O3 • 2 H2O or Cr2(OH3)
Viridian is the standard green and is stable, powerful, and cold with an emerald green undertone. It has a transparent hue, good tinting strength, a dark masstone that can be almost black at full strength, and a slow drying time in oil form. Viridian is commonly replaced by the darker, more saturated, and staining Phthalo Greens, but its properties make it a necessary part of the palette of an experienced landscape painter.
Viridian has excellent permanence, except in high-temperature work, and is highly valued as a glazing color.
Viridian is slightly toxic.
Viridian's name comes from the Latin viridis, meaning green. The process for manufacturing Viridian, or Transparent Oxide of Chromium, was patented by Guignet in Paris in 1859. However, it had actually been discovered by Pannetier and Binet in 1838. Viridian replaced Verdigris, which was reactive and unstable, and Emerald Green, which was a poisonous copper aceto-arsenite used as a rat poison in the sewers of Paris.
Emerald Chromium Oxide, Emeraude Green, French Veronese Green, Guignet's Green, Pannetier's Green, Permanent Green, Smaragd Green, Transparent Oxide of Chromium, Vert Emeraude. Casali's Green and Mittler's Green are varieties of Viridian. Viridian has historically been sold under the name Emerald Green, but they are currently considered to be and are marketed as two different pigments.
Zinc White is the coolest white, and it has a cold, clean masstone and a slightly bluish tint. It has less hiding power and is more transparent than other whites. It dries slowly and is good for painting wet into wet and for glazing and scumbling. Zinc White is neither as opaque nor as heavy as Lead White, its covering power is not as good, and it takes much longer to dry. However, it does not blacken when exposed to sulfur in the air as Lead White does. It is very valuable for making tints with other colors. Unmixed Zinc White dries to a brittle and dry paint film that may crack over the years, so it is not good for frescoing. It is more transparent in acrylic form than Titanium White and is the most commonly used white with gouache. Chinese White is a version of Zinc White appropriate for opaque watercolor techniques.
Zinc White has great permanence and lightfastness.
Zinc White is moderately toxic if ingested and slightly toxic if inhaled.
Though historians are divided on who first isolated the element zinc, they agree that it was first suggested as a white pigment in 1782. Zinc White was accepted as a watercolor in 1834 and was called Chinese White due to the popularity of oriental porcelain in Europe at the time. Ten years later, a suitable oil form was produced. By the early 20th century, it had improved to the point where it was an acceptable alternative to Flake White.
Chinese White, French White, Permanent White, Silver White, Snow White, Zinc Oxide.
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Material Safety Data Sheet
® Grumbacher is a registered trademark of Chartpak.™ Pre-Tested, Superba and Thio are trademarks.


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FarReachChris needed a new web page design and created a contest on 99designs.
A winner was selected from 19 designs submitted by 7 freelance designers.
Looking for a home page PSD (no coding) for a longhorn ranch to feature a few longhorns from a herd.
Big Kahuna Ranch
Homepage for a longhorn cattle ranch used to feature cattle from their herd.
Spot for photos along with description of the ranch.
Top Navigation includes
- Home
- About
- News
- Sale Pen
- Search
- Contact
- Western cowboy kind of feel
- Very clean and simple
- Colors - browns, earth tones. Nothing too bright.
- friendly and warm
- Can include stock photos
- Top navigation
- Banner
- Footer
- Bright colors
- clutter
- No Logo is required at this time.


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Items where Author / Artist / Editor is "Odell, Edward"
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Bloor, Balvinder K. and Tidman, Nicholas and Leigh, Irene M. and Odell, Edward and Dogan, Bilal and Wollina, Uwe and Ghali, Lucy and Waseem, Ahmad (2003) Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization. American Journal of Pathology, 162 (3). pp. 963-975. ISSN 0002-9440


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Domestic Abuse
What to do if you are a Victim of a Domestic Assault or Related Crime
Getting Help
Order for Protection/Restraining Order
Federal Firearms Regulations
Definitions of Domestic Abuse
Domestic Related Crimes
Other Crimes
What To Do If You Are The Victim Of A Domestic Assault Or Related Crime.
Call 911 for police and medical attention. If this is not an option, try to protect yourself as best you can and contact 911 as soon as possible. Try to provide as much information to the 911 call taker as possible. This includes the suspect's location and description, what happened, and if there were any weapons involved. If you know the location of a weapon, tell 911.
If you have injuries, police and medical personnel will attend to these injuries when they arrive.
Provide the responding police officers with as much information as you can. If the offender is still on the scene, direct officers to where that person is. Tell the officers what occurred prior to and during the incident, including what was said and if any threats were made. If a weapon was used, tell the officers its location if you know it and how it was used against you. Advise them of any witnesses to the incident including children who were present. Tell them of any past incidents that may have occurred. The officers may ask some delicate and personal questions. Do not be ashamed to answer them; they are for the purpose of further investigation.
Minneapolis police officers have received specialized training regarding the intricacies and different elements involved in domestic situations. They can offer you temporary shelter if needed and can direct you to the many services provided with in the community. They will provide you with a "blue card" that will have phone numbers to the services and other information about your rights as a victim.
After The Incident
If the offender has been arrested at the scene, several things will take place depending on what the offender was arrested for:
Felony Level.
If the offender was arrested for a felony level crime, the person will be booked into the Hennepin County jail. A probable cause hold will be placed on this person. This hold is usually for about 36 to 48 hours depending on the day and time the person was arrested. An investigator from the Domestic Assault Unit will try to contact you. If you do not have a phone or are some place that the police might not know about, call (612) 673-3072 to contact the investigator who has your case.
The investigator will have reviewed the responding officer's report from the incident any previous reports. The investigator will again ask you about the incident. You will be asked more detailed questions about what happened and if you received injury. The investigator will also ask what you want to do about the case and if you are willing to assist in prosecuting the offender. If you decide not to assist in prosecution, it is very difficult for the investigator to prove the case and it will most likely be closed. If you do want to pursue the case, the investigator will most likely conduct an interview with you and may meet with you to take pictures and sign a medical records release. The investigator will also interview the offender and any witnesses. Further evidence may be requested or collected.
The investigator then presents the case to the county or city attorney. The county attorney handles all felony level cases and the city attorney handles gross misdemeanor and misdemeanor cases. The attorney will decide if the evidence merits charging the offender with a crime. The attorney will also look at the past history of the offender. All of this will occur in the 36 hour probable cause hold time. If charged, the offender will see a judge and bail will be set. The county/city attorney's office will contact you in the future regarding the case.
If the offender is not arrested at the scene, the investigator will most likely contact you and will proceed with the case as described above. This may take several days or weeks. If the county/city attorney decides to charge the offender, a warrant for the arrest of the offender will be issued.
Misdemeanor Level.
If the offender was arrested for a misdemeanor crime, the person will be booked into the Hennepin County jail. Usually the next day, the offender will go in front of a judge and the city attorney will request either release or bail. If you want to have input into this procedure, contact the Hennepin County Domestic Abuse Service Center. They are located at the Hennepin County Government center, 300 S.6th St. # A-level 022. Phone 612-348-5073,TDD 348-2620.
If the person was not arrested and a report was made by the officers, you will need to contact the city attorney's office to follow up on the case if you wish for something to occur. Misdemeanor crimes, including domestic assault, usually do not receive any investigation by the Police Department. Contact the city attorney's office for further information.
Getting Help
There are several agencies in the community which can provide you with assistance, including temporary shelter, legal assistance, counseling and referral services, advocacy programs, interpreter services, and children services.
The Hennepin County Domestic Abuse Service Center is an excellent source. They are located at the Hennepin County Government center, 300 S.6th St. # A-level 022. Phone 612-348-5073,TDD 348-2620.
The Service Center provides all of the services listed above and can assist you in obtaining an order for protection or harassment order. There is also a full time Minneapolis Police sergeant there to assist in investigation and a city/county attorney to assist in prosecution.
Order For Protection/Restraining Order
Once you have obtained an order for protection and if the offender violates it, you need to do several things. If the offender is near you or with you, call 911. Once the order for protection is confirmed, the offender can be arrested for this violation. If the offender is not at your location and is doing some thing to violate the order (such as calling on the phone), call 911 and a report can be taken over the phone about the violation. If you want to follow up on this incident, you will need to contact the city attorney's office to pursue criminal charges against the subject.
Federal Firearms Regulations
As of 1996, federal laws took effect regarding ownership/ possession of firearms or ammunition by persons convicted of domestic assault or are currently under the provisions of an order for protection/restraining order. Violations resulting from this may be federally charged. There is no "grandfather clause" regarding these new laws. Past convictions for domestic assault apply and can limit that person's ability to own or possess a firearm.
Definitions of Domestic Abuse
"Domestic abuse" means the following, if committed against a family or household member by a family or household member: (1) physical harm, injury or assault; (2) the infliction of fear of imminent harm, injury, or assault; (3) or terroristic threats.
"Family or household member" means: (1) spouses and former spouses; (2) parents and children; (3) persons related by blood; (4) persons who are presently residing together or have done so in the past; (5) persons who have a child in common regardless if they have been married or have lived together at any time; (6) a man and a woman if the woman is pregnant and the man is the alleged father regardless if they have been married or have lived together at any time; (7) persons involved in a significant romantic or sexual relationship.
Domestic Related Crimes
Assault. This is the most common crime that is reported to the Minneapolis police department Domestic Assault Unit. There are five levels of assault.
Assault in the first degree (Felony). When a victim sustains "great bodily harm" as the result of an assault. This means when bodily injury creates a high probability of death or causes serious permanent disfigurement or loss or impairment of a bodily member or organ.
Assault in the second degree (Felony). When a victim sustains harm or is subjected to the potential for harm through the suspect's use of a dangerous weapon (firearms, knives, or an object which can be construed as a dangerous weapon).
Assault in the third degree (Felony). When a victim sustains "substantial bodily harm" as the result of an assault. This means when bodily injury results in temporary but substantial disfigurement or impairment of a bodily member or organ.
Assault in the fourth degree (Felony). This level of assault is for law enforcement personnel who are victims of an assault while on duty or for bias motivated crimes.
Assault in the fifth degree (Misdemeanor). There are two parts to this level of assault that constitute fifth degree: when a victim sustains or the suspect attempted to inflict "bodily harm" which is defined as physical pain or injury not covered by the other levels of injury defined above, or when the suspect commits an act with the attempt to cause fear in the victim. Under this statute, the victim does not actually have to be assaulted but only be in fear of being assaulted for law enforcement to take action against the suspect.
Domestic assault
Under this statute, misdemeanor assaults can be enhanced to the gross misdemeanor or felony level if the suspect has previous convictions for assault.
Other Crimes
Terroristic threats (Felony). When a victim is threatened with death or bodily harm by the suspect and that suspect has the ability to carry out this threat. Transitory or threats made "in the heat of passion" are usually not considered terroristic threats and are usually covered under the fifth degree statute.
Interfere with 911 calls (Gross Misdemeanor). If the suspect prevents a victim from making a 911 call for help, the suspect can be charged with this crime. The suspect must make an overt action such as pulling the phone cord out, breaking the phone, or other such action that prevents the call from being made.
Violation of an order for protection/restraining order (Misdemeanor). If a valid court ordered order for protection which has been served to both parties involved is violated, the person violating this order can be charged with this crime. This statute also allows for enhancement to gross misdemeanor or felony level charges if the suspect has previous convictions for this offense.
Other charges which may result from a domestic involved situation are: burglary, kidnapping, criminal sexual conduct, theft, damage to property, arson, stalking, probation/parole violation, and weapons violations.
Last updated Sep 24, 2018


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Sunday, June 19, 2005
at 10:49 AM
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Sharks (Selachimorpha) are a type of fish with a full cartilaginous skeleton and a highly streamlined body. The skeleton of a shark is very different from that of bony fish and terrestrial vertebrates.
at 10:49 AM


text:
http://www.seahawks.com/news/articles/a ... 230102f4bf
Another superb job by Chuck!!
LOL@ "this is my victory formation"
Jville wrote:Terrific fun!
Why can't NFL network and ESPN report that well?
Psychobabbler wrote:Thanks for the pimpin', Griz!
And Vapor, I never really thought about it until I was reviewing this, and I was saying "inconclusive evidence," and I started asking the same thing to myself. Do they say "confirmed" if it is confirmed, and "the play stands as called" when inconclusive? Hmmmm.
Return to [ THE OFFICIAL NET NATION FAN FORUM ]


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I am a physician-scientist and currently a resident in Pathology (Anatomic Pathology only program) at the Department of Pathology of the Stanford University School of Medicine/Stanford Healthcare with a particular clinical interest in Breast Pathology and Molecular Genetic Pathology and a research interest in the development of new quantitative approaches to pathology to accurately predict the development of cancer, correctly classify tumors by prognosis and predict response to cancer therapy, leveraging biomedical informatics and computational pathology tools to inquire large datasets of clinical and genomics data, mostly focusing on breast cancer.
Honors & Awards
Arthur Purdy Stout Stipend Award, Arthur Purdy Stout Society of Surgical Pathologists (2018)
Charles B. Carrington Memorial Prize, Department of Pathology, Stanford University School of Medicine (2017)
Trainee Mentored Award in Precision Health, Department of Pathology, Stanford University School of Medicine (2017)
Junior Career and Development Award, Harvard Medical School - Portugal Program (2013)
Professional Education
Residency, Stanford University School of Medicine / Stanford Healthcare, Residency in Pathology
Postdoctoral Fellowship, Harvard Medical School / Beth Israel Deaconess Medical Center, Bioinformatics (2016)
Postdoctoral Fellowship, Harvard Medical School/Dana-Farber Cancer Institute, Oncology (2015)
Graduate Certificate Program, Harvard Medical School - Portugal Program, Clinical Scholars Research Certificate Training Program 2 (Clinical Research) (2013)
Graduate Certificate Program, Harvard Medical School - Portugal Program, Clinical Scholars Research Certificate Training Program 1 (Clinical Research) (2012)
PhD, University of Porto, Faculty of Medicine, Oncology and Molecular Medicine (2017)
MD/MSc, University of Porto, Faculty of Medicine (2009)
All Publications
- EZH2 protein expression in normal breast epithelium and risk of breast cancer: results from the Nurses' Health Studies BREAST CANCER RESEARCH 2017; 19
Enhancer of zeste homolog 2 (EZH2) is a polycomb-group protein that is involved in stem cell renewal and carcinogenesis. In breast cancer, increased EZH2 expression is associated with aggressiveness and has been suggested to identify normal breast epithelium at increased risk of breast cancer development. However, the association between EZH2 expression in benign breast tissue and breast cancer risk has not previously been evaluated in a large prospective cohort.We examined the association between EZH2 protein expression and subsequent breast cancer risk using logistic regression in a nested case-control study of benign breast disease (BBD) and breast cancer within the Nurses' Health Studies. EZH2 immunohistochemical expression in normal breast epithelium and stroma was evaluated by computational image analysis and its association with breast cancer risk was analyzed after adjusting for matching factors between cases and controls, the concomitant BBD diagnosis, and the Ki67 proliferation index.Women with a breast biopsy in which more than 20% of normal epithelial cells expressed EZH2 had a significantly increased risk of developing breast cancer (odds ratio (OR) 2.95, 95% confidence interval (CI) 1.11-7.84) compared to women with less than 10% EZH2 epithelial expression. The risk of developing breast cancer increased for each 5% increase in EZH2 expression (OR 1.22, 95% CI 1.02-1.46, p value 0.026). Additionally, women with high EZH2 expression and low estrogen receptor (ER) expression had a 4-fold higher risk of breast cancer compared to women with low EZH2 and low ER expression (OR 4.02, 95% CI 1.29-12.59).These results provide further evidence that EZH2 expression in the normal breast epithelium is independently associated with breast cancer risk and might be used to assist in risk stratification for women with benign breast biopsies.
View details for DOI 10.1186/s13058-017-0817-6
View details for Web of Science ID 000396919900001
View details for Original Rain Waterproof Ocean Womens Winter Tall Wellington Hunter Snow Boots q07A5
View details for PubMedCentralID PMC5335498Black Toe Walking Ballerina Flats C Su Standard Toe Comfortable Suede Premier Women's Ballet Slip Closed Pointy On Classic X4ZHwOqY
- Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nature medicine 2017
The bromodomain and extraterminal (BET) family of proteins comprises four members-BRD2, BRD3, BRD4 and the testis-specific isoform BRDT-that largely function as transcriptional coactivators and play critical roles in various cellular processes, including the cell cycle, apoptosis, migration and invasion. BET proteins enhance the oncogenic functions of major cancer drivers by elevating the expression of these drivers, such as c-Myc in leukemia, or by promoting the transcriptional activities of oncogenic factors, such as AR and ERG in prostate cancer. Pathologically, BET proteins are frequently overexpressed and are clinically linked to various types of human cancer; they are therefore being pursued as attractive therapeutic targets for selective inhibition in patients with cancer. To this end, a number of bromodomain inhibitors, including JQ1 and I-BET, have been developed and have shown promising outcomes in early clinical trials. Although resistance to BET inhibitors has been documented in preclinical models, the molecular mechanisms underlying acquired resistance are largely unknown. Here we report that cullin-3(SPOP) earmarks BET proteins, including BRD2, BRD3 and BRD4, for ubiquitination-mediated degradation. Pathologically, prostate cancer-associated SPOP mutants fail to interact with and promote the degradation of BET proteins, leading to their elevated abundance in SPOP-mutant prostate cancer. As a result, prostate cancer cell lines and organoids derived from individuals harboring SPOP mutations are more resistant to BET-inhibitor-induced cell growth arrest and apoptosis. Therefore, our results elucidate the tumor-suppressor role of SPOP in prostate cancer in which it acts as a negative regulator of BET protein stability and also provide a molecular mechanism for resistance to BET inhibitors in individuals with prostate cancer bearing SPOP mutations.
View details for DOI 10.1038/nm.4378
View details for PubMedID 28805820
- Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition. Cancer discovery 2750 Women's Cotu Superga Total Black Sneaker 2017
To investigate immune escape during breast tumor progression, we analyzed the composition of leukocytes in normal breast tissues, ductal carcinoma in situ (DCIS), and invasive ductal carcinomas (IDC). We found significant tissue and tumor subtype-specific differences in multiple cell types including T cells and neutrophils. Gene expression profiling of CD45+CD3+ T cells demonstrated a decrease in CD8+ signatures in IDCs. Immunofluorescence analysis showed fewer activated GZMB+CD8+ T cells in IDC than in DCIS, including in matched DCIS recurrent IDC. TCR clonotype diversity was significantly higher in DCIS than in IDCs. Immune checkpoint protein TIGIT expressing T cells were more frequent in DCIS whereas high PD-L1 expression and amplification of CD274 (encoding PD-L1) was only detected in triple negative IDCs. Co-amplification of 17q12 chemokine cluster with ERBB2 subdivided HER2+ breast tumors into immunologically and clinically distinct subtypes. Our results show co-evolution of cancer cells and the immune microenvironment during tumor progression.
View details for Night Suede Olive Trace Platform Women's Sneakers PUMA YSqTv
View details for PubMedID 28652380
- Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer. JAMA 2017; Women's Sneaker Cotu Total Black Superga 2750 Total Superga Women's 2750 Black Cotu Sneaker 318 (22): 2199–2210
Women's Sneaker Total Black 2750 Cotu Superga Application of deep learning algorithms to whole-slide pathology images can potentially improve diagnostic accuracy and efficiency.Assess the performance of automated deep learning algorithms at detecting metastases in hematoxylin and eosin-stained tissue sections of lymph nodes of women with breast cancer and compare it with pathologists' diagnoses in a diagnostic setting.Researcher challenge competition (CAMELYON16) to develop automated solutions for detecting lymph node metastases (November 2015-November 2016). A training data set of whole-slide images from 2 centers in the Netherlands with (n = 110) and without (n = 160) nodal metastases verified by immunohistochemical staining were provided to challenge participants to build algorithms. Algorithm performance was evaluated in an independent test set of 129 whole-slide images (49 with and 80 without metastases). The same test set of corresponding glass slides was also evaluated by a panel of 11 pathologists with time constraint (WTC) from the Netherlands to ascertain likelihood of nodal metastases for each slide in a flexible 2-hour session, simulating routine pathology workflow, and by 1 pathologist without time constraint (WOTC).Deep learning algorithms submitted as part of a challenge competition or pathologist interpretation.The presence of specific metastatic foci and the absence vs presence of lymph node metastasis in a slide or image using receiver operating characteristic curve analysis. The 11 pathologists participating in the simulation exercise rated their diagnostic confidence as definitely normal, probably normal, equivocal, probably tumor, or definitely tumor.The area under the receiver operating characteristic curve (AUC) for the algorithms ranged from 0.556 to 0.994. The top-performing algorithm achieved a lesion-level, true-positive fraction comparable with that of the pathologist WOTC (72.4% [95% CI, 64.3%-80.4%]) at a mean of 0.0125 false-positives per normal whole-slide image. For the whole-slide image classification task, the best algorithm (AUC, 0.994 [95% CI, 0.983-0.999]) performed significantly better than the pathologists WTC in a diagnostic simulation (mean AUC, 0.810 [range, 0.738-0.884]; P < .001). The top 5 algorithms had a mean AUC that was comparable with the pathologist interpreting the slides in the absence of time constraints (mean AUC, 0.960 [range, 0.923-0.994] for the top 5 algorithms vs 0.966 [95% CI, 0.927-0.998] for the pathologist WOTC).In the setting of a challenge competition, some deep learning algorithms achieved better diagnostic performance than a panel of 11 pathologists participating in a simulation exercise designed to mimic routine pathology workflow; algorithm performance was comparable with an expert pathologist interpreting whole-slide images without time constraints. Whether this approach has clinical utility will require evaluation in a clinical setting.
View details for DOI 10.1001/jama.2017.14585
View details for PubMedID 29234806
- 2750 Total Sneaker Cotu Black Women's Superga Precision Cancer Diagnostics: Tracking Genomic Evolution in Clinical Trials PLOS MEDICINE 2016; 13 (12)
In a Perspective, Francisco Beca and Andrew Beck discuss Charles Swanton and colleagues' accompanying Research Article on somatic mutations in patients with inflammatory breast cancer treated in a Phase II clinical trial.
View details for DOI 10.1371/journal.pmed.1002177
View details for Web of Science ID 000392142400004
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View details for PubMedCentralID PMC5140044
- The clinicopathologic and genomic features of fibrotic foci in breast cancer - results from the TCGA cohort NATURE PUBLISHING GROUP. 2018: 50
- Molecular Cytology Applications in Metastases Molecular Applications in Cytology Springer Nature Switzerland AG. 2018; 1: 247–259
- Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling CANCER RESEARCH 2017; 77 (3): 790-801
Despite the high incidence of oncogenic mutations in PIK3CA, the gene encoding the catalytic subunit of PI3K, PI3K inhibitors have yielded little clinical benefit for breast cancer patients. Recent epidemiologic studies have suggested a therapeutic benefit from aspirin intake in cancers harboring oncogenic PIK3CA Here, we show that mutant PIK3CA-expressing breast cancer cells have greater sensitivity to aspirin-mediated growth suppression than their wild-type counterparts. Aspirin decreased viability and anchorage-independent growth of mutant PIK3CA breast cancer cells independently of its effects on COX-2 and NF-κB. We ascribed the effects of aspirin to AMP-activated protein kinase (AMPK) activation, mTORC1 inhibition, and autophagy induction. In vivo, oncogenic PIK3CA-driven mouse mammary tumors treated daily with aspirin resulted in decreased tumor growth kinetics, whereas combination therapy of aspirin and a PI3K inhibitor further attenuated tumor growth. Our study supports the evaluation of aspirin and PI3K pathway inhibitors as a combination therapy for targeting breast cancer. Cancer Res; 77(3); 790-801. ©2016 AACR.
View details for DOI 10.1158/0008-5472.CAN-16-2400
View details for Web of Science ID 000393194400019
View details for PubMedID 27940576
View details for PubMedCentralID PMC5290090
- Total Cotu Superga Black 2750 Sneaker Women's Dieulafoy's Lesion Pathology of the Gastrointestinal Tract edited by Carneiro, F., Chaves, P., Ensari, A. Springer International Publishing. 2017; 1: 177–179
- LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer ONCOTARGET 2016; 7 (50): 81981-81994
Long non-coding RNAs (lncRNAs) have been implicated in normal cellular homeostasis as well as pathophysiological conditions, including cancer. Here we performed global gene expression profiling of mammary epithelial cells transformed by oncogenic v-Src, and identified a large subset of uncharacterized lncRNAs potentially involved in breast cancer development. Specifically, our analysis revealed a novel lncRNA, LINC00520 that is upregulated upon ectopic expression of oncogenic v-Src, in a manner that is dependent on the transcription factor STAT3. Similarly, LINC00520 is also increased in mammary epithelial cells transformed by oncogenic PI3K and its expression is decreased upon knockdown of mutant PIK3CA. Additional expression profiling highlight that LINC00520 is elevated in a subset of human breast carcinomas, with preferential enrichment in the basal-like molecular subtype. ShRNA-mediated depletion of LINC00520 results in decreased cell migration and loss of invasive structures in 3D. RNA sequencing analysis uncovers several genes that are differentially expressed upon ectopic expression of LINC00520, a significant subset of which are also induced in v-Src-transformed MCF10A cells. Together, these findings characterize LINC00520 as a lncRNA that is regulated by oncogenic Src, PIK3CA and STAT3, and which may contribute to the molecular etiology of breast cancer.
View details for DOI 10.18632/oncotarget.11962
View details for Web of Science ID 000391352800005
View details for PubMedID 27626181
View details for PubMedCentralID PMC5347668
- MicroRNA signatures in cytopathology: Are they ready for prime time? CANCER CYTOPATHOLOGY 2016; 124 (9): 613-615
View details for DOI 10.1002/cncy.21728
View details for Web of Science ID 000383685600003
View details for PubMedID 27153190
- Intratumor Heterogeneity in Breast Cancer NOVEL BIOMARKERS IN THE CONTINUUM OF BREAST CANCER 2016; 882: 169-189
Superga 2750 Women's Black Sneaker Cotu Total Abstract
Intratumor heterogeneity is the main obstacle to effective cancer treatment and personalized medicine. Both genetic and epigenetic sources of intratumor heterogeneity are well recognized and several technologies have been developed for their characterization. With the technological advances in recent years, investigators are now elucidating intratumor heterogeneity at the single cell level and in situ. However, translating the accumulated knowledge about intratumor heterogeneity to clinical practice has been slow. We are certain that better understanding of the composition and evolution of tumors during disease progression and treatment will improve cancer diagnosis and the design of therapies. Here we review some of the most important considerations related to intratumor heterogeneity. We discuss both genetic and epigenetic sources of intratumor heterogeneity and review experimental approaches that are commonly used to quantify it. We also discuss the impact of intratumor heterogeneity on cancer diagnosis and treatment and share our perspectives on the future of this field.
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View details for Web of Science ID 000376034700008
View details for PubMedID 26987535
- Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer BMC CANCER 2015; 15
PPP2R2A deletions were recently linked to a subgroup of luminal breast carcinoma (BC) that exhibits poor survival. This subgroup also exhibited amplification of a chromosome region containing the Cyclin D1 coding gene, CCND1. Therefore, we aimed to investigate whether a combination of PPP2R2A (B55α) and Cyclin D1 expression statuses evaluated by immunohistochemistry (IHC) could define a subgroup of luminal BC that exhibits poor survival.First we conducted a retrospective cohort study using sequencing data from The Cancer Genome Atlas initiative to correlate PPP2R2A copy number alteration (CNA) status with its expression level and the corresponding overall survival (OS). Next, also using a retrospective cohort study design, we evaluated the PPP2R2A (B55α) expression levels by IHC in a total of 807 BC patients from two independent cohorts (discovery cohort n = 349 and validation cohort n = 458). Cyclin D1 expression was also evaluated, and the PPP2R2A (B55α)(-/low)/Cyclin D1(high) phenotype was evaluated as a predictor of disease-free survival (DFS) and OS in luminal-like BC patients.Deletions in the PPP2R2A gene strongly correlate with lower mRNA expression and poorer OS. PPP2R2A (B55α)(-/low) carcinomas have significantly shorter DFS and OS. Furthermore, in univariate analysis, the PPP2R2A (B55α)(-/low)/Cyclin D1(high) phenotype is significantly associated with poorer DFS and OS. In a multivariate analysis, the PPP2R2A (B55α)(-/low)/Cyclin D1(high) phenotype is significantly associated with poor DFS, thus defining a group of luminal-like BC with higher risk of relapse.We demonstrate that BCs harboring PPP2R2A deletions are associated with worse OS. Moreover, this is the first study to demonstrate that the combination of altered PPP2R2A (B55α) and high Cyclin D1 expression by IHC defines a subgroup of luminal-like BC patients with a high risk of relapse and death.
View details for DOI 10.1186/s12885-015-1266-1
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View details for PubMedID 25879784
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- p-mTOR expression is associated with better prognosis in luminal breast carcinoma JOURNAL OF CLINICAL PATHOLOGY 2014; 67 (11): 961-967
Despite considerable interest in the PI3K/AKT/mTOR pathway in breast carcinomas (BC), published data reports contradictory results regarding the association of phosphorylated mammalian target of Rapamycin (p-mTOR) expression with clinico-pathological features and prognosis in BC. Here, we evaluate the main clinico-pathological associations with p-mTOR expression in BC, with focus on the different molecular subtypes.In this retrospective study, 331 BC patients were included in final analysis. Outcome measures included disease-free survival (DFS) and overall survival (OS) times. Baseline data and outcome measures were compared between immunohistochemical p-mTOR expressing and non-expressing BCs. Subgroup analysis was performed to assess the effect of p-mTOR expression in the outcome for each BC molecular subtype.43.8% of the tumours were positive for p-mTOR, with a significant correlation between p-mTOR expression with smaller (<2 cm) (p=0.021) and lower-grade tumours (p<0.001). Expression of p-mTOR was also associated with longer DFS (HR of 0.32, p<0.001) and OS (HR of 0.20, p<0.001). In a multivariable analysis, the HR remained significant with minimal change (HR=0.26, p=0.002 for OS; HR=0.40, p=0.002 for DFS). In subgroup analysis, luminal p-mTOR-expressing tumours demonstrated longer DFS and OS (HR 0.33, p=0.003; HR 0.20, p=0.003, respectively) independently of size, grade, lymph node status and Her-2 overexpression.p-mTOR expression is associated with smaller, lower-grade and with luminal BC. In multivariable analysis, p-mTOR expression was associated with longer DFS and OS, independently of the size, grade and lymph node status, especially in luminal BCs.
View details for DOI 10.1136/jclinpath-2014-202320
View details for Web of Science ID 000344067700006
View details for PubMedID 25053543
- Genotypes and Prevalence of HPV Single and Multiple Concurrent Infections in Women with HSIL DIAGNOSTIC CYTOPATHOLOGY 2014; 42 (11): 919-923
The contribution of human papillomavirus (HPV) types to the carcinogenesis of cervical cancer has been established for a long time. However, the role of phylogenetically related and rare variants remains uncertain, as well as the influence of concurrent multiple HPV genotypes infection. We aimed at studying the prevalence of several HPV genotypes infecting women with single versus concurrent multiple HPV genotypes infection with a HSIL diagnosis in a cervical cytology. We conducted a cross-sectional study using Thin-Prep(®) liquid-based cervical cytology specimens with the diagnosis of high-grade squamous intraepithelial lesion (HSIL), in which HPV genotype was sequentially tested. Genotypes were determined with a PapilloCheck(®) system, a DNA-Chip for the type-specific identification of 18 high-risk and six low-risk types of HPV. Of the total study population, 176 cases had a diagnosis of HSIL and positive HPV genotyping result, being HPV16 the most prevalent genotype (48.86%; 95%CI: 41.58-56.19) followed by HPV31 (14.20%; 95%CI: 9.75-20.18). Concurrent multiple HPV genotypes were detected in 36.93% (95%CI: 30.15-44.27) of the patients. The prevalence of the 10 most common HPV genotypes detected varied significantly according to the presence of single vs. concurrent multiple HPV genotypes (P = 0.022). Moreover, women with concurrent multiple HPV genotypes were on average 3.53 (95%CI: 0.43-6.64) years younger than women with single genotype infection. Our results suggest that women with multiple genotype HPV infection differ in terms of age and distribution of the most prevalent HPV genotypes. Additionally, we provide further evidence of the predominance of HPV16 in HSIL lesions of the uterine cervix.
View details for DOI 10.1002/dc.23143
View details for Web of Science ID 000343969900001
View details for PubMedID 24623593
- Tumor Heterogeneity: The Lernaean Hydra of Oncology? ONCOLOGY-NEW YORK 2014; 28 (9): 781-784
- Metastatic breast cancer: mechanisms and opportunities for cytology CYTOPATHOLOGY 2014; Women's 2750 Cotu Superga Sneaker Total Black 25 (4): 225-230
Despite significant advances in diagnosis, surgical techniques, general patient care, and local and systemic adjuvant therapies, metastatic disease remains the most critical condition limiting the survival of patients with breast cancer. Therefore, the development of effective treatment against late-arising metastasis has become the centre of clinical attention and is one of the current challenges in cancer research. A deeper understanding of the metastatic cascade is fundamental, and the need for repetitive tumour assessments for the evaluation of tumour evolution is a relatively new practice in routine medical care. As such, fine needle aspiration cytology (FNAC) is ideally placed to monitor biological changes in metastasis that may affect treatment and response. As FNAC is a minimally invasive method, it can be performed repeatedly with relatively little trauma, and selective ancillary tests can be applied to FNAC specimens, including for tumour whose primary nature is known. Herein, we review how the linear and parallel models explain metastatic dissemination, thus influencing therapeutic and clinical decisions, and how cytology, together with immunocytochemistry and molecular analysis, can be a tool for routine clinical practice and clinical trials aimed at metastatic disease with a special emphasis on breast cancer.
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View details for Web of Science ID 000340667500002
View details for PubMedID 24889678
- Cotu Superga Sneaker Black Total 2750 Women's Tactoid body features in a Schwann cell hamartoma of colonic mucosa INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 2014; 22 (5): 438-441
Mesenchymal colorectal polyps are uncommon lesions, particularly those of neurogenic origin. We describe a mucosal Schwann cell hamartoma of the colon with tactoid features, so far reported in peripheral nerve sheath tumours, and address its differential diagnosis and clinical implications.A 72-year-old man underwent screening colonoscopy that presented a 5-mm polyp on distal sigmoid. Histologically, it displayed a lesion in the lamina propria comprising oval structures with tactoid features and bland spindle cells, entrapping adjacent crypts. No ganglion cells were seen. Spindle cells expressed only S-100 protein and vimentin.Mucosal Schwann cell hamartoma was recently recognized as distinct from common (submucosal) colorectal Schwannomas and so far not associated to inherited syndromes. Thus, it should be considered in the differential diagnosis of look-alike lesions (eg, ganglioneuroma, neuroma, and neurofibroma) that may occur in the setting of inherited syndromes such as Cowden syndrome, multiple endocrine neoplasia-2B, and type 1 neurofibromatosis.
View details for DOI 10.1177/1066896913501384
View details for Web of Science ID 000340174500009
View details for PubMedID 23994879
- 2750 Women's Superga Total Cotu Black Sneaker Growing Indication for FNA to Study and Analyze Tumor Heterogeneity at Metastatic Sites CANCER CYTOPATHOLOGY 2014; 122 (7): 504-511
In routine practice, suspected metastases in patients with cancer are only occasionally biopsied, primarily because of the cost and invasiveness of the procedure. However, biopsies of metastatic lesions can be valuable, not only in confirming the presence of metastatic disease, but also in revealing unsuspected benign disease or secondary malignancies. In addition, such biopsies also allow the assessment of biomarkers that might differ from those on primary tumor cells, and can thereby facilitate selection of the optimal treatment. Because of the increasing recognition of clonal and phenotypic heterogeneity of tumors, we anticipate that in the near future, biopsying of metastatic lesions will constitute a standard-of-care practice, allowing assessment of molecular differences between the primary tumor and metastatic lesions. In our opinion, fine-needle aspiration is currently the best method for making repeated biopsies to monitor the tumor: it is minimally invasive, safe, and cost effective and can be coupled with modern ancillary techniques. Here we provide an up-to-date review of the clinical implications of tumor heterogeneity in metastatic disease and the ancillary molecular techniques used in cytology; we also discuss the role of modern cytology in contemporary diagnosis and management of metastatic cancer.
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View details for Web of Science ID 000340531400005
View details for PubMedID 24478259
- Primary relapse site pattern in women with triple-negative breast cancer PATHOLOGY RESEARCH AND PRACTICE 2014; 210 (9): 571-575
Despite the remarkable improvements in breast cancer (BC) characterization, accurate prediction of BC clinical behavior is often still difficult to achieve. Some studies have investigated the association between the molecular subtype, namely the basal-like BC and the pattern of relapse, however only few investigated the association between relapse pattern and immunohistochemical defined triple-negative breast cancers (TNBCs). The aim of this study was to evaluate the pattern of relapse in patients with TNBC, namely the primary distant relapse site. One-hundred twenty nine (129) invasive breast carcinomas with follow-up information were classified according to the molecular subtype using immunohistochemistry for ER, PgR and Her2. The association between TNBC and distant relapse primary site was analyzed by logistic regression. Using multivariate logistic regression analysis patients with TNBC displayed only 0.09 (95% CI: 0.00-0.74; p=0.02) the odds of the non-TNBC patients of developing bone primary relapse. Regarding visceral and lymph-node relapse, no differences between in this cohort were found. Though classically regarded as aggressive tumors, TNBCs rarely development primary relapse in bone when compared to non-TNBC, a clinical relevant fact when investigating a metastasis of an occult or non-sampled primary BC.
View details for DOI 10.1016/j.prp.2014.05.011Cowboy Boots Western Stitched Cowgirl Wine Aldo J'aime Tall TEX Women's 25 004zpf
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View details for PubMedID 24939141
- Improved malignancy prediction by B3 breast lesions subclassification ANNALS OF DIAGNOSTIC PATHOLOGY 2013; 17 (5): 434-436
Black Total Women's 2750 Cotu Superga Sneaker Core-needle biopsy (CNB) of breast lesions can be classified into 5 categories according to lesion type and associated risk of malignancy. B3 category (lesion of uncertain malignant potential) constitutes a challenging problem in clinical decision, with most ending in excisional biopsy. Therefore, the aim of this study was to establish the incidence of malignancy on excision biopsy of B3 lesions and assess if subclassification (in B3a and B3b categories) according to the presence of atypia in otherwise B3 lesions better predicts malignancy on excision. Forty-eight cases with diagnosis of B3 lesion on CNB and matched surgical excision specimen were included to evaluate the positive predictive value (PPV) and odds for malignancy in CNB. All cases were further subclassified into B3a and B3b categories. B3 category lesions had an overall PPV for malignancy of 12.5% and significant low odds of malignancy of 0.14. When subclassified, B3b (lesions with atypia) demonstrated a higher PPV for malignancy (36.36%) with a nonsignificant odds. Inversely, B3a (lesions without atypia) demonstrated a PPV for malignancy of only 5.41% and a significant low odds of malignancy of only 0.06. The described low rate of malignancy in some of B3 lesions additionally reinforces the practice of avoiding surgical excision in selected patients and provides data that additionally support B3 lesion subclassification according to the presence of atypia. Subclassification of B3 category can further refine the current classification of associated risk of malignancy with possible implications in clinical management.
View details for DOI 10.1016/j.anndiagpath.2013.05.003
View details for Web of Science ID 000324896100009
View details for PubMedID 23773891Soda Round Shoes Cute Slip Women's Sneaker Tracer Flat Perforated Black Toe Black S On 8PWqrn8
- Loss of caveolin-1 and gain of MCT4 expression in the tumor stroma Key events in the progression from an in situ to an invasive breast carcinoma CELL CYCLE 2013; 12 (16)Sneaker Black Superga Total Cotu 2750 Women's : 2684-2690
The progression from in situ to invasive breast carcinoma is still an event poorly understood. However, it has been suggested that interactions between the neoplastic cells and the tumor microenvironment may play an important role in this process. Thus, the determination of differential tumor-stromal metabolic interactions could be an important step in invasiveness. The expression of stromal Caveolin-1 (Cav-1) has already been implicated in the progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC). Additionally, stromal Cav-1 expression has been associated with the expression of stromal monocarboxylate transporter 4 (MCT4) in invasive breast cancer. However, the role of stromal MCT4 in invasiveness has never been explored, neither the association between Cav-1 and MCT4 in the transition from breast DCIS to IDC. Therefore, our aim was to investigate in a series of breast cancer samples including matched in situ and invasive components, if there was a relationship between stromal Cav-1 and MCT4 in the progression from in situ to invasive carcinoma. We found loss of stromal Cav-1 in the progression to IDC in 75% of the cases. In contrast, MCT4 stromal expression was acquired in 87% of the IDCs. Interestingly, a concomitant loss of Cav-1 and gain of MCT4 was observed in the stroma of 75% of the cases, when matched in situ and invasive carcinomas were compared. These results suggest that alterations in Cav-1 and MCT4 may thus mark a critical point in the progression from in situ to invasive breast cancer.
View details for DOI 10.4161/cc.25794
View details for Web of Science ID 000326703800028
View details for PubMedID 23907124
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- Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types JOURNAL OF CLINICAL PATHOLOGY 2013; 66 (3): 187-191
CD44, CD24 and ALDH1 are the most consistently used biomarkers to identify and characterise the breast cancer stem cell (CSC) phenotype. However, most studies performed until now analysed samples of invasive ductal carcinomas of no special type (IDC-NST). Therefore, prevalence and clinical significance of these CSC markers in breast carcinomas of special histological types (SHT) is largely unknown. For that reason, this study aims to determine the distribution of the breast CD44, CD24 and ALDH1 CSC markers among a series of invasive breast carcinomas of SHT, in comparison with a series of IDC-NST.117 invasive SHT breast carcinomas were analysed for the expression of CD44, CD24 and ALDH1, by immuhohistochemistry. The distribution of these CSC markers was evaluated among the distinct histological special types, and the results were compared with a series of 466 IDC-NST.The expression prevalence of the breast CSC markers differed between special types and IDC-NST. Medullary, papillary and tubular carcinomas were enriched in the CSC phenotype CD44(+)/CD24(-/low) (80.0%, 100.0% and 100.0%, respectively, vs 45.3% in IDC-NST). Considering the ALDH1 cytoplasmic tumour expression, only medullary and metaplastic carcinomas displayed significant increase in CD44(+)/CD24(-/low)/ALDH1(+) CSC phenotype frequency (36.4% and 28.6%, respectively, vs 4.8% in IDC-NST).The expression distribution of breast CSC markers is largely dependent on histological type. Interestingly, within the distinct SHT, medullary and metaplastic carcinomas are the two types highly associated with high-grade carcinomas, basal-like and claudin-low molecular subtypes, and to the CSC phenotype CD44(+)/CD24(-/low)/ALDH1(+).
View details for DOI 10.1136/jclinpath-2012-201169
View details for Web of Science ID 000315292200003
View details for PubMedID 23112116
- Oral squamous cell carcinoma in a Crohn's disease patient taking azathioprine: Case report and review of the literature JOURNAL OF CROHNS & COLITIS 2012; 6 (7): 792-795
Thiopurines are widely used for remission maintenance and post-operative recurrence prevention in Crohn's disease. The increased risk of cancer in transplant recipients on azathioprine is well recognized and there are concerns that this may also be true for inflammatory bowel disease patients. We report a case of a 33-year-old Caucasian woman with Crohn's disease treated with azathioprine for 9 years who developed an ulcerated lesion at the right superior retromolar trigone. Biopsy specimen revealed a squamous cell carcinoma.
View details for DOI 10.1016/j.crohns.2012.03.004
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- Training does not affect exhaled nitric oxide in competitive swimmers ALLERGY 2008; 63 (5): 623-624
View details for DOI 10.1111/j.1398-9995.2008.01659.x
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View details for PubMedID 18394139


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A couple of weeks ago, Nickelodeon announced that it's going to start airing "classic" episodes of its teen shows from the 1990's. This is based on overwhelming Facebook demand from nostalgic millennials. Starting on July 25, between the hours of midnight and 4 am, insomniacs in my generation will be treated to a bloc of programming including Keenan & Kel, All That, Clarissa Explains it All, and Doug. Everyone's totally excited. Democracy! Will of the people! Memories so think you'll have to brush them away from your faces!
Popular demand will continue to drive the bloc's schedule. Reports the New York Times,
The channel says that Facebook feedback will influence which other shows it rotates into the block. Research has convinced Nickelodeon executives that the Web - a repository of cherished childhood memories - "is allowing young people to be nostalgic, probably sooner than other generations," said Cyma Zarghami, the channel's president.
As I was born in the early 80's, one would think that I'd be in the sweet spot for this stunt, that nostalgia would pull me to my TV and compel me to watch along with my brethren. My generational narcissism and love of democracy would compel me to adamantly voice my opinion about what shows should air, and voice them just about as hard as I possibly could. The reality is that I missed this aspect of pop culture, I feel nothing about All That, and what I know of Keenan & Kel confuses and upsets me.
I was what you might call a pop culture pariah when I was a kid. I grew up in a rural remote area, far enough out of the nearest small enough town that cable TV wasn't an option for us, and my parents sure as hell weren't going to shell out for a giant satellite dish, as my dad was known to instruct my siblings and I to go outside and run around in order to "get the stink off." (To this day, I'm not sure what that means.) We watched PBS (Wild America with Marty Stouffer was my jam, and Square 1 made me briefly want to be a mathematician when I grew up, because I thought mathematicians solved mysteries) and read the encyclopedia and did other rural nerd things. We gardened and chopped wood and identified songbirds and made maple candy like Laura Ingalls Wilder and lived a life blissfully unaware of what was going on in the world of cable television. My relative country bumpkin innocence and lack of exposure to pop culture continued until I was almost in eighth grade, when I went to student council camp and made a bunch of kids laugh when I asked who was singing the song that had just started playing on the radio. It was "Spiderwebs" by No Doubt, and they thought I was being sarcastic.
While I don't begrudge any of you suburban (or non-rural remote) kids who grew up with Nickelodeon, I won't be pumping my fists joyfully skyward at the Doug theme song. I'll be sullenly looking for the theme song from 3-2-1 Contact on youtube. I'll indulge my television nostalgia when there's a late night Ghostwriter bloc.


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Double Cross
- Synopsis
- Just when Alex Cross's life is calming down, he is drawn back into the game to confront a criminal mastermind like no other. The elaborate murders that have stunned Washington, DC, are the wildest that Alex Cross and his new girlfriend, Detective Brianna Stone, have ever seen. This maniac adores an audience, and stages his killings as spectacles in public settings. Alex is pursuing a genius of terror who has the whole city on edge as it waits for his next move. And the killer loves the attention, no doubt-he even sets up his own Web site and live video feed to trumpet his madness.And in Colorado, another criminal mastermind is planning a triumphant return. From his supermaximum-security prison cell, Kyle Craig has plotted for years to have one chance at an impossible escape. If he has to join forces with DC's Audience Killer to get back at the man who put him in that cell--Alex Cross--all the better.From the author Time magazine has called "the man who can't miss," Double Cross has the pulse-racing momentum and electrifying thrills that have made James Patterson a #1 bestselling storyteller all over the world.
- Copyright:
- 2007
Book Details
- Book Quality:
- Publisher Quality
- 9780316026109
- Related ISBNs:
- 9780316015059
- Publisher:
- Little, Brown and Company
- Date of Addition:
- 10/27/11
- Copyrighted By:
- James Patterson
- Adult content:
- No
- Language:
- English
- Has Image Descriptions:
- No
- Categories:
- Literature and Fiction, Mystery and Thrillers
- Submitted By:
- Bookshare Staff
- Usage Restrictions:
- This is a copyrighted book.


text:
nd4spd needed a new button or icon design and created a contest on 99designs.
A winner was selected from 8 designs submitted by 5 freelance designers.
Need a set of icons to represent the different forums located on my site.
I would like an icon created that represents the name and content of each of the forums listed at http://www.motorcycleaddicts.org/forums.php
- Icons should be 48x48 pixels
- Icons should have transparent backgrounds
- Icons should be in GIF format
- Item 1...


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This week's French Fridays with Dorie recipe, St-Germain-des-Prés Onion Biscuits, is Dorie's adaptation of the basic American biscuit. She adds chopped and quickly sauteed onions to the dough, cuts the dough into trendy cocktail-size rounds, and serves them with country ham and Champagne. Dorie's biscuits, named after her swanky Paris neighborhood, are now a staple at her cocktail parties.
|St-Germain-des-Prés Onion Biscuits
I needed to make a meal out of these biscuits, so I decided to do a slight twist on Country Benedict, which replaces the English muffin, ham and hollandaise sauce in traditional Eggs Benedict with an American biscuit, sausage patties, and country gravy. The poached eggs are replaced with eggs fried to choice. I used St-Germain-des-Prés Onion Biscuits, sausage patties made with Jimmy Dean sage sausage, and country gravy; I did stay with poached eggs.
|French Country Benedict


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G Carlson needed a new logo design and created a contest on 99designs.
A winner was selected from 86 designs submitted by 36 freelance designers.
GreenLight Wireless
We are an authorized dealer for several different cellular carriers. We are opening a store that will be selling all kinds of cellular accessories and we will be carrying several different cellular carriers.
We are targeting new customers and existing cellular customers. Our customers purchase cell phones that require no credit check and no contract. They are typically looking for low cost cell phones and accessories.
We want the logo to be FUN!!!! Please see logo attached for an idea of what we are looking for. The idea of the store is that we have so many accessories and phone carriers that it resembles a jungle thus the name of the store "Cellular Jungle". We would like to see a monkey, palm tree, etc. anything that reminds customers of a jungle. The design will be used as the logo for the store. That logo will be used on all printed material, both screenprinted and embroidered apparel, a Channel Letter Sign for the front of the building, etc. We would like to see the store name staggered, one lower than the other.
Find out how a design contest works or learn more about our logo design services.


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Dearest Ramses, what a fine-looking Chartreuse grey boy you are! And such good company to all your kitty pals and your doggy pal and your human pals. What a love-filled home you all share with such a great family!
Congratulations, darling Ramses, on being selected today's Cat of the Day! We hope you, Anubis, Isis, Jane, Phoenix, Jerry, and your humans are all enjoying a wonderful day of celebration, full of fun and lovies and all your favorite treats with lots of yogurt.


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I have previously recommended Bernard Lewis's memoir, Notes on a Century, for its wonderful combination of insight and anecdote regarding life, the study of history, and the Middle East. The following anecdote is among my favorites:
Sometime in the early 1970s at a time when I was in Tehran, Senator Kennedy suddenly arrived, unannounced and unexpected. The Shah was angry. He felt that a visit by a U.S. Senator, particularly one with the dynastic name of Kennedy, was a state occasion and that he should therefore have been notified in advance so that appropriate arrangements could be made.
Despite his annoyance, however, the Shah felt that he had to go ahead and do something to honor so distinguished a visitor. He dealt with this problem by finding a subtle Iranian way of honoring and rebuking Senator Kennedy at the same time.
The Palace gave a formal dinner at which the Senator was the guest of honor. However, the Shah himself did not participate in this dinner, but instead left the task of presiding to his teenage granddaughter. From an Iranian point of view this sent a clear message.
The Senator, however, was delighted . . . I was invited to this dinner . . . and I have no doubt that he enjoyed this dinner with the teenage girl much more than he would have enjoyed it with His Imperial Majesty . . .
The Senator was, I am told, quite unaware of the fact that he was being subtly rebuked.


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As we reach the midway point of "The Ultimate Fighter 14: Team Bisping vs. Team Miller," we get another two-fight lineup with tonight's episode.
As the episode begins, the previous fight is still a hot topic, specifically arguments over whether Team Bisping's Akira Corassani tapped in the first round before an eventual decision win over Team Miller's Dustin Neace.
Team Miller assistant coach (and longtime Miller trainer) Ryan Parsons confronts Michael Bisping about his poor sportsmanship. And after Bisping says something about making more money than Parsons, the coach said he now understands why the fighter is the most hated guy in the UFC.
In the Team Miller locker room, everyone tries to console Dustin, who feels he got a bum deal because of the possible tap-out that went unnoticed by the referee.
But with that controversy now behind us, we move forward.
Pre-fight (No. 1)
Miller knows his last/No. 4 featherweight pick Steven Siler wants to prove himself by taking out Team Bisping's top pick, Diego Brandao. Meanwhile, Bisping and Diego are very confident he's the clear favorite. Bisping, though, is concerned he may be overconfident, and he thinks everyone is sleeping a bit on Steven. Additionally, there are questions about Diego's conditioning, and Bisping worries he's not resting enough before the fight.
Keith Kizer oversees the eventual weigh-ins. Steven and Diego both weigh 146 pounds and cleared to compete.
Steven, who upset notable Micah Miller in the elimination round, misses the people back at home, including his girlfriend. Diego discusses his rough upbringing, in which he lost his dad when he was just 14 and then got into a life of selling drugs. MMA eventually got him off the streets and into the gym, where he can help see through a promise he made to his dad to take care of the family.
The fight (No. 1)
In the night's first fight, we have Team Miller's Steven Siler (17-6) vs. Team Bisping's Diego Brandao (13-7).
UFC president Dana White does the standard pre-fight introductions, referee Josh Rosenthal is officiating the fight, and we're underway.
Diego opens and misses with a flying knee that Bisping immediately admonishes. But he then lands a nice overhand right before Steven answers with a straight right while avoiding an uppercut. Diego lands another overhand punch that staggers Steven. He follows him into the cage with another knee and then drops Steven with a vicious two-punch combo. And this fight is over in quick fashion due to the TKO.
The trash-talking between the coaches begins moments later, even as the ref announced the official result. As Team Miller heads back to the dressing room, Bisping chases after them with taunts. Miller isn't sure why Bisping is so hostile but ultimately surmises it's because he has a small penis.
Pre-fight (No. 2)
At a Team Bisping session, everyone seems to be gunning for a fight with Roland Delorme, Team Miller's last pick and the guy they consider the easiest opponent. But when Roland shows up at the gym, Miller and Parson notice his ankle has swollen substantially, and they worry it may be a staph infection since he's not injured. They decide to keep it quiet from everyone.
At the fight announcement, Bisping grandstands and continually insults Team Miller. But he ultimately gets to the pick, and it'll be "Prince" John Albert (Team Bisping's No. 3 bantamweight pick) against John Dodson (Team Miller's No. 1 pick). John immediately hugs "Prince."Team Bisping seems annoyed that T.J Dillashaw (Team Bipsing's No. 2 pick), who's boasted about being the team's best fighter, has taken the easier road with team Miller's Roland Delorme (Team Miller's No. 4 pick), who's secretly at the ER getting his foot checked out.
"Prince" says he's not bothered by the tougher fight. At a Team Bisping session, he shows well-rounded skills, and Bisping thinks he's got the best punching among the show's bantamweights. At Team Miller, John is still largely the odd man out because of his mole role and leaking the fight announcements to Team Bisping. But his upbeat personality eventually gets him back in Miller's good graces. Miller, though, says John is very high-energy, but he's also lazy and has untapped potential.
The weigh-ins aren't shown, but both fighters apparently make weight.
The fight (No. 2)
It's fight day, and we have Team Miller's John Dodson (11-5) vs. Team Bisping's "Prince" John Albert (6-1).
Dana again does the intros, and Steve Mazzagatti serves as ref.
We're underway, and it seems John is going to have some issues with "Price's" longer reach. John, though, unloads a nice combo and follows with a low kick. "Prince" then just barely checks a heavy head kick. John gets through another combination. "Prince" circles away and regroups and looks fine. John lands a nice body kick and darts out of range. He returns with a body punch and low kick. "Prince" returns a low kick. John shows nice footwork and lands another body kick. John fails on a takedown but lands some punches. "Prince" then clinches and unloads some knees, but he's tagged with punches and staggered. John unloads more punches and a knee, but "Prince" takes him to the mat. But during a scramble, John ends up on top. "Prince" works his way back to his feet, but he's exhausted. The pace slows as "Prince" throws single strikes, but John darts in with a knee. "Prince" becomes the more active fighter, but he doesn't have much behind his shots, and John tags him with a kick to the ribs. "Prince" answers with one of his own. John works some kick-punch combos. "Prince" nearly gets a takedown at the end of the round but ends up on his back and eats hammerfists before the horn sounds. The round belongs to John, 10-9.
John works low kicks but then slips when he's accidentally kicked in the groin. He's back up and shakes it off, and we're underway again. John pushes forward with punches, but "Prince" easily defends. John lands a nice lunging punch to the body. "Prince" lands a low kick, but John answers with a head kick that partially connects. The fighters trade in the center of the cage, and the round is up for grab midway through. "Prince" snaps off a nice low kick and then takes John's back from a standing position. But he slips off and goes to the mat, and John works from top with punches before "Prince" gets back up. John works more low kicks before clinching and forcing the fight to the mat. He quickly lets "Prince" back up, though. John lands some two-punch combos as "Prince" wings tired punches. There's little action late, but John scores a late takedown before fighting off "Prince's" amrbar attempt. It's a closer round, but John likely takes it 10-9.
Sure enough, there's no third round, and John Dodson gets the win via 20-18 scores.
And with that, Team Miller takes a 5-2 lead through the season's first seven fights. Up next week are the final opening-round fight and the announcement of the semifinal matchups.
For the latest on this season and past episode recaps, stay tuned to "The Ultimate Fighter 14" section of MMAjunkie.com (www.mmajunkie.com).
Catch new episodes of "The Ultimate Fighter 14: Team Bisping vs. Team Miller" every Wednesday at 10 p.m. ET/PT on Spike TV. MMAjunkie.com recaps each episode of the reality series, and full series coverage can be found on "The Ultimate Fighter 14" page.


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i'm up to my eyes in cloth diapers.
and I like it.
i feel like I'm doing something good.
for my baby.
and for me.
i'm going to be honest with you though.
i hate doing laundry.
and dirty diaper laundry is stinky.
even if your baby is breastfed.
even if it's just pee.
you have to have the right soap.
you have to know about your water.
there is a system.
wash at least 3 times before using.
rinse cold.
wash hot.
they get more absorbent with time.
but these are not like your momma's diapers.
they are soft.
they are snappy.
they are cute.
they adjust to grow with your baby.
and I like that.
it's a familiarity thing.
then a confidence thing.
and if you watch my baby.
i promise to leave you with disposables.


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The Barleycorn to open in the former Burgermeister's spot
Brothers Greg and Jon Campbell have had enough of exclusive gated communities and stodgy office parks. They recently relocated to Asheville from south Florida, and they're hoping to discover a more sociable way of living.
This fall, they'll open The Barleycorn in West Asheville with that goal in mind.
"We're going for a gathering place where you can get something good to eat," Greg says.
The restaurant's tagline, "a great good place," comes from writer Ray Oldenburg's 1989 book, The Great Good Place, which argues the importance of so-called third places in creating healthy lives.
"A great good place is a place where people can come and meet their neighbors, or a guy's out walking his dog, and he can sit down and have a beer," Greg says. "Basically, it's going to be based on the British pub tradition."
Accordingly, The Barleycorn will serve fare from that region: bangers and mash, pork pies, Irish stew. There will also be sandwiches, soups, salads and cheese boards for sharing.
And as the name implies, beer will be plentiful with about 16 varieties on tap, which explains the barley reference. It draws from a folk song about harvest, "John Barleycorn Must Die," written down by the Scottish poet Robert Burns and recorded, perhaps most famously, by Traffic.
Greg summarizes the song: "You plant the barley. You plant the corn. It grows up, and you kill it so you can produce beer and spirits. … And then you plant it again."
The Barleycorn occupies the former Burgermeister's space at 697 Haywood Road. Renovations are already underway. The revamped interior will include a longer bar, a semi-open kitchen and a change in decor (no more vinyl appliques on the walls).
Circle in the Square on Merrimon becomes Grand Central
Don't worry north Asheville: Merrimon's Circle in the Square is no more, but the pizza train is still in the station.
The business has become Grand Central Pizza & Deli. Byron Carlile, who managed the restaurant for nine years, recently bought it and changed the name — although most everything else remains.
"We've kept all the pizza exactly the same," says Shelby Young, who works with Carlile. "That's pretty important to our customers."
The phone number, however, has changed. For Grand Central, call 254-4403.
The Biltmore Avenue Circle in the Square remains open under its original ownership.
Chef Mo's on Hendersonville Road closes
After 3 ½ years in business, Chef Mo's Restaurant and Bar has closed. "Basically, it just wasn't the right location for us," says Brenda Wienke, who co-owns the business with chef Mauricio Abreu. "We decided after some soul searching that we needed to leave."
Abreu has been cooking in Asheville for more than a decade, and he's co-owned restaurants since 2004, when he opened Chef in Motion on Victoria Road.
Is he retiring? Not likely. He and Wienke, will continue to operate Mountain Fiesta event center in Madison County where they host weddings and cooking classes. Abreu will offer private chef services.
Look for an upcoming collaboration between Abreu and Carson Lucci, who owns Over Easy Café and Golden Girls Events Staffing. Abreu will help with Golden Girls' catering projects and possibly host some dinners at Over Easy, which is usually only open for breakfast and lunch, Wienke says.
For more information, visit goldengirlseventsstaffing.com or mountainfiesta.com.


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Steinar Klein needed a new logo design and created a contest on 99designs.
A winner was selected from 75 designs submitted by 25 freelance designers.
The whole idea is to make another way to sell DVD`s. The whole concept is that we will make it easy for people to make a private DVD collection.
Film lovers
The files we will require are:
Print file format - .ai (CMYK)
Web file format - .jpg and layered .psd (RGB)
Please do not use any stock images or clip art in the logo
Find out how a design contest works or learn more about our logo design services.


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The USDA has issued the results of the first Conservation Reserve Program (CRP) general sign-up in four years. Announced on July 26 the sign-up ran from Aug. 2 through Aug. 27.
To be eligible, the land had to be cropped for four of the six production years from 2002 through 2007.
"The 2008 farm bill revised the total maximum number of acres allowed in CRP to 32 million," said Jonathan Coppess, FSA administrator, during a Tuesday press conference touting the program. "At this point, there are more than 31 million acres enrolled in the various CRP programs, including the continuous sign-up program and the Conservation Reserve Enhancement Program (CREP).
"However, at the end of this fiscal year – which is in about 16 days – somewhere around 4.45 million CRP acres currently under contract will expire."
USDA's goal, therefore, "was to accept enough acres in the general sign-up to bring the CRP enrollment to a level that would maximize the program and still give leeway to add new continuous sign-up and CREP acres along the way. (All this) while remaining under the statutory cap of 32 million acres."
Among the results:
During the August sign-up, producers across the country made more than 50,000 offers totaling more than 4.8 million acres.
The USDA is accepting 4.3 million of those acres into the CRP program.
This year, the average rental payment, per acre, is $46.03. CRP payments are made in arrears.
"This means the expected national CRP enrollment beginning on Oct. 1, 2010, will stand at 31.2 million acres, including the newly enrolled acres," said Coppess. "That leaves approximately 800,000 acres that can be enrolled in continuous CRP sign-up and CREP throughout fiscal year 2011."
A majority of approved contracts are for 10-year commitments.
"The CRP contract begins Oct. 1, 2010, and runs through Sept. 30 of the ending year (in most cases, 2020)," said Brandon Willis, FSA deputy administrator for farm programs.
What happens next?
"FSA county offices will notify producers and work with them to ensure all signatures are obtained," said Willis. "That way, CRP contracts can be approved … by the end of this month. In some cases, only one of the (necessary) parties signed the contract during sign-up and now the others must sign on."
Due to relatively short sign-up period, FSA authorized the use of interim conservation plans so contracts could be expedited.
"For this sign-up, only, the contract may be approved based on the interim plan. However, a final conservation plan is required by the end of this year."
Willis said producers can withdraw from CRP contracts without any penalties before the final conservation plan is developed.


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Marc Jacobs Debuts New Nail Polish on Miley Cyrus
Wondering just how involved Marc Jacobs really is with the beauty look at each runway show? Very. He even mixed the quirky shade of brown nail polish on his S/S 14 runway himself. The grungy colour, called Bark!, complimented the rich green and blue liners used around the models' eyes, while the black rhinestones aligned across the top of each nail (4,500 in all!) lent the choppy blonde wigs some sophistication. "This colour's a bit murky, it's all a little bit wrong," says manicurist Marianne Newman, who painted 970 nails with just one coat before the show. "It's imperfect perfection!"
No one expects you to wear the wigs or the dramatic liner in real life, but Miley Cyrus, who makes her high fashion campaign debut in the controversial ads, does sport Bark! on her nails. Perhaps it was only a matter of time before nude nail polish, everyone's latest crush, went over to the dark side. Look for the colour at Sephora this summer.


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COLLECTION: Raw Spectrum by Jo Bellamy
Jo Bellamy_6Photo 8 of 8
Raw Spectrum by Jo Bellamy features vivids and bolds with color pops through the hair color. The vision for this collection was to be able to show movement through color, to explore really organic textures and look to marry elements of the fabrics used in the styling to both contrast and compliment the shape and form of the hair.
From an era of New Romantics depicted through a tangible nod to Ziggy Stardust in image three, to a deconstructed pompadour inspired by pin up Betty Grable in image four, this collection is a modern take on icons of yesterday.
There is an element of nostalgia conveyed by the slight sepia tone of the backdrop, and yet the collection remains progressive through each girl's modern editorial poise.
For more information about Jo Bellamy Hair, visit www.facebook.com/JoBellamyHairdressers.
Collection: Raw Spectrum
Hair: Jo Bellamy
Photography: Karla Majnaric
Make-up: Isabella Schimid
Styling: Alicia Doust


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Become a Nurse >> Browse Articles >> NCLEX
NCLEX Study Guide
The NCLEX-RN exam focuses primarily on eight Client Needs categories. Each category assesses a nurse's ability to address a patient's primary health needs in a wide range of medical scenarios. The questions are further broken down into four types of Integrated Practices (Nursing Process, Caring, Communication and Documentation, Teaching/Learning), which focuses on the ways that nurses approach client needs. The key difference between the two is ability vs. approach.
Focus on the specific Client Needs techniques, terms and concepts that are listed on each of the content area pages linked below, but realize that these questions are going to be asked from four distinct Integrated Practice angles.
Management of Care: Properly managing a patient's care while still complying within all necessary regulations. Exam takers should err on the safe side and ensure that their answers do not compromise the patient's safety.
Safety and Infection Control: Protecting patients and other health care workers from various health and environmental hazards.
Health Promotion and Maintenance: Overseeing prevention and detection of patient health problems.
Psychosocial Integrity: Maintaining the mental and emotional health of patients and their families.
Basic Care and Comfort: Providing basic comfort and assistance to patients and assist them with the tasks of daily living.
Pharmacological and Parenteral Therapies: Administering medication and measure patient vital signs.
Reduction of Risk Potential: Mitigating the possibility of post-procedure complications and/or infections.
Physiological Adaptations: Managing and providing care to chronically ill patients.


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So, that Suárez goal from earlier this week? We think Southampton striker Dani Osvaldo topped it today.
Osvaldo's equalizer is breathtaking for a lot of reasons, most of which come before he ever actually strikes the ball. Dare we say it's Messi-esque? Is that an insult? If so, to whom? Make your arguments below. [NBCSN]


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Testosterone: A Man's Guide
September/October 2010
Got a comment on this article? Write to us at email@example.com.
Endocrine Society Calls for Medicare Coverage of DXA Bone Density Testing to Be Extended to Men With Testosterone Deficiency
This article was provided by Positively Aware. It is a part of the publication Positively Aware. Visit Positively Aware's website to find out more about the publication.
Add Your Comment:
(Please note: Your name and comment will be public, and may even show up in
Internet search results. Be careful when providing personal information! Before
adding your comment, please read TheBody.com's Comment Policy.)


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|EWTN's Catholic Experts
Rev. Kenneth Brighenti, PhD
Matthew Bunson,
Warren H.
Carroll, Ph.D.
Colin B. Donovan, STL
A layman, Mr. Donovan has the Licentiate in Sacred Theology, with a specialization in moral theology, from the Pontifical University of St. Thomas Aquinas (Angelicum) in Rome, where he wrote on the Donation of the Spouses in Marriage. He earned the B.Th. from the Seminary of Christ the King in Mission, BC, Canada, and the BA in Biological Science from Northwestern University, Evanston, IL. Prior to coming to EWTN in 1995, he taught Theology at Aquinas College in Nashville, as well as served in the U.S. Navy as a shipboard Communications Officer.
Anthony Dragani, Ph.D.
Mr. Robert J. Flummerfelt, JCL
Peggy Frye
Father Mark J. Gantley, JCL
Dr. Richard
David M. Gregson,
Fr. John Echert, S.S.L.
Father Echert writes a column on the monthly readings of the Mass for "The Catholic Servant," a monthly publication for Evangelization, Catechesis and Apologetics available on the internet at www.catholicservant.org .
Karl Keating
Robert Klesko, MA.
During his ministry he has worked in the Apostolate of Marriage Enrichment establishing successful Natural Family Planning programs on the diocesan and parish levels. Father is a priest in the Archdiocese of Oklahoma City.
Richard M. Hogan was born in Minneapolis, Minnesota on July
31, 1951, the oldest of six children. He attended Catholic grade
school and high school, graduating summa cum laude from the
University of St. Thomas in St. Paul in 1973 with a B.A. in
history. The next year was spent studying history at the University
of Munich in Germany on a Fulbright grant. Returning to the
Twin Cities, Fr. Hogan attended graduate school at the University
of Minnesota earning a M.A. and Ph.D. in medieval history in
1975 and 1978 respectively. He was ordained a Roman Catholic
priest for the Archdiocese of St. Paul and Minneapolis in 1981.
Fr. Matthew Habiger was ordained in 1968. He has held a variety of positions in the service of the Church. His first assignment was to a large parish in Burlington, Iowa where for four years he experienced the many challenges made upon a parish priest. His next assignment was four years as Newman chaplain for the University of Kansas. Here he discovered the need of the Church to address the intellectual life. During the summers of these eight years he acquired a masters degree in catechetics and a masters degree in academic theology.
In 1976 he was assigned to teach theology at Benedictine College in Atchison, Kansas and to be the college chaplain. This familiarized him with the problems and challenges of higher Catholic education. Between 1980 and 1985 he earned a doctorate in moral theology at the Catholic University of America, under the direction of Dr. William E. May. For the next five years he resumed teaching theology and served as college chaplain at Benedictine College.
In 1990 he began a ten year tour of duty proclaiming the Gospel of Life throughout the world, as a member of Human Life International, where he eventually served as President and Chairman of the Board. He has done two series for EWTN, on Catholic Social Teaching and on the 25th anniversary of Humanae Vitae, and was a guest on various EWTN shows. He has lectured extensively throughout the world in 55 countries to a wide variety of audiences on the life issues, and has first hand experience of the problems confronting the culture of life.
[In December of 2000 he returned to St. Benedict's Abbey, where he was the Director of Retreats, while also giving NFP Weekend Parish Missions, and providing occasional Hispanic Outreach, Prison Ministry and serving as Abbey Librarian.]
In July of 2003 he
accepted a full time position with NFP Outreach, which provides
NFP weekends at Parishes and Parish Missions based on the four
pillars of the Catechism of the Catholic Church. He also
provides seminars on the Theology of the Body, and Clergy
Conferences to help priests and deacons address these issues
from the pulpit.
Fr. Robert J. Levis
Although retired from teaching and from EWTN's Expert Forums, Fr. Levis continues to educate through the Forum's database of his past answers.
Jason Morin
Luis Rodriguez
Fr. Vincent
Father Jonathan S. Toborowsky
Fr. Stephen F. Torraco
Although Father Stephen returned to the Lord on 27 September 2010, he continues to teach through his answers to questions in EWTN's Forum database.
Fr. John Trigilio
Mr. Michael Trueman, JCL
Mr. Carlos Venegas, JCL
Jan Wakelin