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The app market has become a very important one, and it comes down to numbers: As of May, 50.4 percent of Americans used smartphones, according to a Nielson report; we're seeing new statistics on how they invade our personal lives; both the Google Play Marketplace and iOS App Store are well beyond the 20 billion download mark at this point; and, perhaps most telling, using a smartphone to make a call comes in as the fifth most popular function — most of it is spent using apps.
Suffice it to say that apps are big business.
Singular app developers aren't the only ones who've noticed the trend, and a new wave of app creation and management platforms are hitting the scene to help with monetization as well. And that includes newly launched Canadian import, Ooomf, which has also just announced an impressive $500k round of seed funding led by Real Ventures with help from BDC Venture Culture and a handful of other angel investors as well.
The Montreal-based Ooomf began as a Startup Weekend pitch that pivoted during the team's time in an accelerator program. "We had two major evolutions," founder Mikael Cho tells me. "The first idea was to help people market their products online with influencers, and we saw that what we were doing with that was incremental, and not a big change. We had feedback from our users and we started thinking about our backgrounds in user experience and design and marketing, and thinking about the problems we could really solve there. So we started thinking about mobile and we saw that our expertise really aligned with mobile."
The other piece of Ooomf's evolution was nailing down the specifics of how it would help app developers. So for starters, the service creates a Website for its users. "One of the things they had to do in getting their app out there was make a site, because Apple requires it," says Cho. "And we were like "oh, okay, right away, we'll do that for you.'" He describes the process as incredibly simple — we're talking Tumblr simple, people — and says it takes less than a minute to have your app's Web landing page up and running. Sure, it's a little thing, but it's an effective one; the caliber of an app's proprietary page is sort of like a book cover — we're not supposed to judge it, but lots of us most certainly do.
As the team has refined the product, it's added a community element to Ooomf. "We allow people to participate in the creation of an app," says Cho. "So if you have an idea or a prototype or a design, you can put it on Ooomf and let the community vote on features and participate in it." Crowdsourcing leaves no stone untouched, and that's quickly including app creation. There are a handful of companies pre and post-launch who are doing this exact thing, though using a variety of mechanisms to encourage audience participation. But the idea remains the same: Everyone has an app idea, and this is a place to put them.
The other beast of a problem Ooomf is tackling is app discovery. If you haven't noticed, the consumer and developer world largely hates the App Store's feeble attempts at showcasing apps and helping us find new ones. In addition to supporting and participating in app creation, users can also make their own curated app catalogs. "You identify as a creative, or a traveling nomad, or a hustling innovator, and we have different apps in each category," Cho tells me. "But the entire idea is to be a part of the whole life cycle of an app, from idea to creation." Ooomf also offers a "Coming Soon" category to help with discovery of upcoming apps — something that developers fear in the App Store: If you don't crack the top on your debut day, you can sink fast and furiously.
Apple's lack of App Store discovery upgrades has been a boon to teams like Ooomf: It's basically ceded an entire platform to outsiders. Of course, we now have word that Apple is about to flip a switch and turn Genius on for the App Store, and that some of that Chomp acquisition will finally be making its debut. I asked Cho if there's any fear on Ooomf's part about this, and he seems to feel the way that I do about it: Too little, too late. He also mentions that Apple's App Store algorithms still allow the Ooomf team to offer something useful.
At the moment, everything on Ooomf is free, and will remain so for pure users. Cho says that within the year, paid-for features will be introduced on the developer-side and it will either be based on the number of apps someone is making or the numbers of things they use Ooomf to help them do. He also talks about working with developers on incentivizing user participation — like offering people early beta testing or future discounts on in-app purchases if they were there from day one.
Clearly, Ooomf's strategy is to give developers a stage — which is surprisingly becoming tricky territory these days. "I definitely think it's important to really cater to developers. You've seen with Twitter the massive growth that occurred because, yes, there were users, but because every developer was building a Twitter client or something for the application," Cho says. "There was so much open data and Twitter was able to grow massively because of that."
"Eventually, we'll have our own data and open our own API, and we'll use the App.net approach."
Today, Ooomf is available via Web and also has optimized its site for mobile. The iOS app will launch this November.


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Hotel Pas Cher
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Business and Sustainable Development
For the business community, sustainability is more than mere window-dressing. By adopting sustainable practices, companies can gain competitive edge, increase their market share, and boost shareholder value.
What's more, the growing demand for 'green' products has created major new markets in which sharp-eyed eco-entrepreneurs are reaping rewards.
This site explains the strategies and tools that companies can use to translate an aspiration for sustainability into practical, effective solutions. Case studies from around the world are provided.
The site's six sections cover:
BSDGlobal was published in 2002 as a general guide for the private sector: its content is foundational and continues to be relevant.
|Permissions - Web Master - Copyright © 2013 International Institute for Sustainable Development


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Permanent filtration systems in wastewater collection require rigorous testing to ensure their efficiency and reliability. Don't risk shutting down your entire operations for these vital tests. Rain for Rent provides a complete line of temporary portable sand media filtration, particulate filtration and bag filtration units that can be scaled to any effluent flow requirements.
Geothermal Field Loops are often used to heat and cool homes. From time to time, the liquid used in those systems needs to be purged, cleaned and filtered. Rain for Rent has a complete line or portable centrifugal and high-head rental pumps that can be specified to your purging project. Whether our smaller duty DV80c three-inch pump for smaller Geothermal Field Loop system purging, or larger pumps, our sales engineers will help you pick the perfect pump to safely purge your system.
In a continually evolving world of federal and state environmental requirements, the ability to discharge water on or near your jobsite requires attention to all regulations. Rain for Rent trains its sales force to be up to date, and help you comply with all environmental regulations for dewatering discharge. Sand media, bag and cartridge filtration units can be easily designed into a dewatering system to save you money by eliminating water transportation costs. For PCB remediation and superfund sites, Rain for Rent employs a veteran team of pumping and filtration experts to save you time.
Municipal heat exchangers require a large quantity of water for hydrotesting purposes. Rain for Rent offers complete water storage and filtration systems that permits a municipal entity, or its selected contract hydrotest company, the chance to save water and conserve water on large hydrotest projects. By using steel frac tanks to capture used hydrotest water and running it through a filtration system, used hydrotest water is quickly filtered and clean. This will speed up your hydrotest process, making the water ready for re-use or environmentally friendly discharge.
A contractor testing the plumbing and HVAC system in a 13 story building reached out to Rain for Rent. The test water had to be pumped through the building's pipes and then directed to a temporary tank. From there it would be filtered to meet city standards and discharged into the sewage treatment system.
An environmental remediation contractor was hired to treat soil at an aging automobile service station. The contractor needed to pump groundwater to a tank, pass it through a carbon filter, then discharge to the publicly owned treatment system. The temporary nature of this Rain for Rent designed system allowed the environmental contractor to save money on fluid transportation fees and treat the contaminated soil and water on site.
With the cost of fuel continually rising, a contractor approached Rain for Rent for a solution to reduce iron levels from thousands of feet of aging pipeline. The high levels of iron prevented safe disposal through the public treatment system. Using media filtration and portable water quality monitoring the water could be continually filtered until it reached iron levels safe enough for discharge into sewer treatment.


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Field for Board of Regents president down to 3
HARTFORD -- Jack R. Warner heads the Board of Regents in South Dakota, a state where the legislative season lasts all of 38 days.
Gregory W. Gray has been all over the map, from New York to Miami to Riverside, Calif.
Jay Kahn, who calls higher education a passion, is interim president at Keene State College in New Hampshire.
All three were in Connecticut last week to tell a variety of audiences that becoming president of the state's Board of Regents for Higher Education is their dream job.
A decision on who will get the job won't be made until the board meets April 4.
"One was livelier than the others, but I am not going to tell you which one," said Anita Gliniecki, president of Housatonic Community College in Bridgeport.
The finalists were culled from 29 candidates who applied for the job, including seven who were interviewed. The man who gets the job will replace the system's first president, Robert Kennedy, who resigned in disgrace last fall after it was discovered he doled out more than $250,000 in raises without board approval.
The salary of the next president has not been publicly revealed. Kennedy earned a base salary of $377,000 plus perks that brought his bottom line to more than $445,000.
All three talked about the challenge of helping the state build a new higher education system. The Board of Regents oversees the 17 campuses that comprise the state university system, community college system and Charter Oak online college.
The new board and Connecticut State Colleges and Universities, or ConnSCU as it will be called, was the idea of Gov. Dannel P. Malloy, who chose Kennedy before the new Board of Regents was even in place.
The University of Connecticut is the state's only institution of higher education that is not part of ConnSCU.
While in Connecticut, the three candidates met privately with the Board of Regents' search committee. They met with a system-wide advisory committee, college and university presidents, system executive staff, and members of the public in a session that drew a sparse crowd of fewer than a dozen people.
Warner peppered his public session with his philosophies. He said someone once asked him what anyone could possibly do with a psychology major.
"Be the CEO of the South Dakota Board of Regents," Warner replied.
Gray called it exciting to have the opportunity to shape a higher education system.
"I love a great challenge," offered Kahn, who said the system merger is being watched elsewhere around the country.
The new system was pushed as a way to save money, which could be used to hire more faculty, although that has yet to happen.
While the Board of Regents is conducting the new search, state Rep. Roberta Willis, D-Lakeville, said she wishes the board had waited.
Willis, co-chairwoman of the Legislature's higher education committee, said her panel has voted on a new selection process that puts the board, rather than the governor, in charge of the hire.
The committee would no longer make the president's contract concurrent with with the governor's term.
"I wish we could have made the change before they began the search," Willis said. "I feel that the pool of candidates may have been greater, and maybe more diverse, if the selection process had been changed previously."
Others called the three finalists a strong pool.
Philip Austin, interim president of the system and former president of the University of Connecticut, said all three finalists have different strengths.
"Any one of them, I think, can provide leadership," Austin said. "I will make sure the person who signs the contract knows of the obstacles and the challenges."


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Your tropical holiday in paradise.
A magical oasis in a tropical paradise, Banana Fan Sea Resort lies on the most beautiful part of Samui's famous Chaweng Beach in the Gulf of Thailand, with the finest white and powdery sand. Located at the south end of Chaweng Beach, yet not too far away from the famous shopping, entertainment and nightlife areas.


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Monday, February 6, 2012
Pros and Cons of Camping
We went camping at Innes National Park last weekend and had an amazing time. However, camping with three young children is not always easy. Let me share with you some of the highs and lows.
Pro - Spectacularly beautiful beaches with soft white sand
Con - Fine black sand that gets into every nook and cranny
Pro - Inquisitive wildlife visiting every morning and evening
Con - Inquisitive wildlife ripping through our rubbish and scratching at our tent in the middle of the night wanting our food (they kept coming back so we had to put the food in the car)
Pro - Letting the kids run and play with the other camping kids
Con - Trying to stop the kids from kicking up huge dust balls into other people's tents (and making 'snow angels' in the dirt)
Con - Long drop toilets
Pro - Amazingly they didn't smell!
Pro - Discovering an amazing cave that opened up into a magical rockpool. The sand in the rockpools was incredibly soft and billowy and we could have stayed all day!
Con - We brought soap to try to bathe, but the soap just wouldn't lather in the salt water and turned into wax!
Pro - Enjoying the simple joys of camping - discovery walks, card games, telling stories in the tent.
Con - Being up half the night with a baby, so she wouldn't wake the rest of the camp ground.
It was tiring but definitely worth it.
And for those of you living in Australia - two things ...
I'm so excited to be attending the "Power of Moms" Sydney Conference on March 16th and 17th. You can win a free pass over at Seven Cherubs and Retromummy! The retreat is going to be fantastic and I can't wait! I'm even making a list of questions... its getting long.
And I've joined the One Million Kilo Challenge. It's going really well (except for the chocolate cake with chocolate ganache last night). One week down, 9 to go. My scales are broken, so I'm not sure if I've lost any weight, but my stomach felt flatter this morning, so I'm taking that as a good sign. I'm not really following it properly, just trying to exercise everyday and have healthy snacks instead of chocolate. Anyone else taking part?
8 comments:
Be grateful, Kate, that your night-time visitors were only kangaroos and not bears and crocodiles - which were always a possibility when we camped in the Everglades (in Florida) when I was a kid! Looks like you had a wonderful time!!ReplyDelete
Been there! Although only with 2 kids but it gets easier as they get older, it is fantastic family time that they will remember forever!ReplyDelete
Wow, that is the world's most beautiful camping place!! We've all got our wildlife issues - here it is raccoons and bears. The raccoons are a nuisance, but the bears are very scary (typically we camp on a no-bear island, so phew!). Are the roos a worry with children around, or just harmless food seekers? I just love it that you are okay with your kids getting dirty - that's the absolute best part of camping!ReplyDelete
That beach looks beautiful, as does the cave. I bet you enjoyed that first shower/bath when you got home!ReplyDelete
Yes, thank goodness we don't have the threat of bears! The kangaroos and wallabies are harmless, so that's not a worry, but we do have deadly snakes, spiders and sharks to deal with!ReplyDelete
I am totally doing the million kilo challenge I've lost 4kg so far :)ReplyDelete
I really love the sticky chicken!!!
You know me and camping, while the scenery looks lovely I need power and hot water and when it takes 6 hours to set up I also need a week to make it worth while. BTW I also need flushing toilets lol
I laughed when I read your soap comment! I used to be a sailor and we would have salt water showers. The trick was using castile soap (in the States I use Dr. Bronner's liquid) which lathers in almost anything. Hopefully that will help on future adventures!ReplyDelete
Aww looks like you had so much fun! I love the last photo of Gracie crawling up the sand trying to play with the big kids! So cute! Miss you!ReplyDelete
Thanks so much for leaving a comment! I try to respond but life sometimes gets in the way. If you have any questions please email me at kateeconklin(at)gmail(dot)com


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By Andrew M. Seaman
NEW YORK (Reuters Health) - When Massachusetts blazed the trail of healthcare reform in 2006 by expanding coverage for the poor and requiring all residents to have health insurance, it may have done more than serve as a model for nationwide reform: it also seemed to save lives, according to a study released on Monday.
The findings, reported in the Annals of Internal Medicine, are the first to provide a detailed analysis of the effects of systematically expanding healthcare coverage. Increasing access to Medicaid, the government-run insurance program for the poor, and mandating that everyone have health insurance were the two centerpieces of Massachusetts' healthcare reform.
They are also central to President Barack Obama's 2010 Patient Protection and Affordable Care Act, and remain its most controversial elements. Half the states have refused to expand Medicaid under the law known as Obamacare, for instance, and Republican opponents of the law regularly rail against the individual mandate requiring that individuals buy insurance or pay a penalty.
The study's authors cautioned that their analysis does not prove that Massachusetts's healthcare overhaul caused the decline in deaths; all it can show is that the two are correlated.
Previous studies that examined whether expanding access to health insurance resulted in fewer deaths got mixed results.
The new study compared deaths among people aged 20 to 64 years old in Massachusetts counties before and after "Romneycare" (as the health insurance overhaul is known, since Republican politician Mitt Romney was governor when it became law) to counties in other states.
The years compared were 2001-2005 and 2007-2010.
For every 830 people who became insured as a result of Massachusetts' mandatory coverage and Medicaid expansion, they calculated, one fewer person died each year.
That represents "a 3 percent decline in the death rate in the first few years after implementation," lead author Dr Benjamin Sommers of Harvard School of Public Health in Boston told Reuters Health.
In particular, there were fewer deaths from cancer, heart disease and infections, all of which benefit from preventive and regular healthcare, said Sommers. He has served as a senior advisor to the U.S. Department of Health and Human Services, the lead Obamacare agency, and continued to serve part-time in an advisory role in 2013-2014.
"The decline in the death rate of Massachusetts was focused in those areas where you would think reform would make the biggest difference," he said.
The drop in deaths was also larger in poorer communities that had a high number of uninsured residents before 2006.
Austin Frakt, a health economist with the Department of Veterans Affairs in Jamaica Plain, Massachusetts who was not involved in the new study but wrote an editorial accompanying it, called it "one of the most relevant studies pertaining to the Affordable Care Act."
Most such studies do show that health insurance has a positive effect on death rates and health, Frakt told Reuters Health: "Those findings are out there and the findings are really robust."
Sommers cautioned that the findings may not apply nationwide. For one thing, Massachusetts has an abundance of doctors and hospitals, many of whom accept the newly insured. Under Obamacare, people whose new insurance is not accepted by many healthcare providers might have coverage on paper but not easy access to healthcare.
The Congressional Budget Office estimates that 37 million people will gain health insurance by 2018 through the Affordable Care Act.
SOURCE: bit.ly/SQRXAa Annals of Internal Medicine, online May 5, 2014.
Reporting by Andrew Seaman; Editing by Genevra Pittman, Sharon Begley and Chris Reese


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21c Museum Hotel
Traveling is all about fun, discovering new places and making memories that last long beyond check-out. In Ohio, the fun definitely begins at check-in. Who wouldn't want to indulge their inner child and stay in a treehouse?! If you're a fan of knights and royalty, perhaps a castle stay would be more to your liking. How about a 100-year-old building that features contemporary art? Gypsy wagon? Yurt overlooking an African-like savannah where wild animals are roaming? Got it covered…. And then some.
Just take a look around, and we think you will find something that works for you and yours. Whether you are into camping, glamping, B&Bs, country inns or uptown modern, there are plenty of accommodations to suite your style and your idea of fun!


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Grand Slam Wrestling THIS SATURDAY, New Venue! Jan 09 - 11:10 pm EST
Live Report by natestein
Grand Slam Wrestling THIS SATURDAY, New Venue!
GSWrestling.com - Grand Slam Wrestling is in action with "Grand Slam to the Future" THIS SATURDAY, January 14 at our own, brand new building, 1 Maxson DR, Old Forge, PA, wth a 7 pm bell time!
It's 2017, a new year, in a new building, and a new direction for GSW!
- GSW Heavyweight champion "Maniac" Mike Vaughn defends against "Hot Property" Fire Ant!
- DeSean Pratt (formerly Amasis) returns to action against "The Kentucky Gentleman" Chuck Taylor!
- GSW Tag Team champions The Takeover (Adam Falcon, Joe Quick) vs. Skyros and Riddick!
- GSW Adrenaline champion Brute Van Slyke vs. "Mr. Saturday Night" AJ Evers!
- "Young Dynamite" Jay Freddie vs. "Your Technical Nightmare" Matt Turner!
- Kevin "The Man" Graham vs. "Cinema" Stevie Shields
The inauguration of Phil Stamper to another term as #PresidentOfWrestling, Andy Header, Rex Taylor, The Impeccables, Commander Ephex, Sean Silence, Wild Phoenix, and more!
Tickets just $10 (Kids 12 and under free with paid adult). Show your support on Facebook at facebook.com/events/355671938133571!
facebook.com/grandslamwrestlingpa - twitter.com/GSWrestling
(See the commercial for January 14 at bit.ly/gsw51c)


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MONTEVALLO, Ala. – It's somehow fitting that the 500th win of Georgia College head coach Terry Sellers' career would come in his home state, on a University of Montevallo campus that he spent five years as a young assistant coach in the late 70s. It's also fitting that the Bobcats (4-2) would need the grit and determination Sellers has instilled in all of his 17-plus years as GC head coach to pull out a 67-66 win over the University of North Alabama (2-4).
The Bobcats led in a runaway at halftime, 40-19. The Lions came out of the break a different team, knocking down a whopping 60 percent (15-25) of their second-half shots. UNA eventually took over the lead at the 13:39 mark in the second half, holding it for the next 11:40 until a Jared Holmes (Indianapolis) jumper gave the advantage back to GC.
Over the final 2:59, the Bobcats would spread the wealth, with Holmes, Ryan Aquino (Roswell, Ga.), Andre Mikell (Snellville, Ga.) and Mike Augustine (Waterloo, Ill.) all scoring points. Augustine gave the Bobcats a three-point lead with seconds left on a pair of free throws, his only two points in the game. UNA would cut the lead to one with two tosses of its own, but get no closer.
Holmes finished with 25 points, a GC career-high for the junior college transfer from Kankakee Community College. Holmes also pulled down six boards while shooting 8-of-12 from the floor.
Aquino was the only other Bobcat in double-digit scoring with 12 points, yanking down seven boards. Leading the team in rebounds was senior forward Josh Hurst (Athens, Ga.), nabbing 11 with six points. Mikell had a solid line of nine points, four rebounds, three assists and four steals.
GC shot 40 percent (25-63) from the floor while the Lions hit for 44 percent (20-45). The Bobcats held a slight rebound advantage at 39-34, but cleaned up on the offensive glass 15-6.
Sellers hit a pair of milestones this season, getting his 300th win as GC head coach in the win over Carson-Newman College Nov. 19. He is now 500-248 (.668) all-time as a collegiate head coach, including his nine seasons at Alabama Southern Community College.
The Bobcats return home to square off against Lander University (3-2, 0-1 PBC) Saturday, Dec. 4 at 3:30 p.m. in this season's opening Peach Belt Conference (PBC) match-up for GC. The Bearcats most recently lost to Division I Winthrop University 65-46 this evening.
The Georgia College Department of Athletics, back-to-back winners of the PBC Commissioner's Cup, sponsors 10 varsity athletic programs at the NCAA Division II level. As a Division II program, Bobcat Athletics prides itself on balancing the life of the student-athlete, evidenced by the teams' multiple appearances in post-season competition as well as documented academic success and community-service involvement. Sign up at www.twitter.com/GCSUBobcats and www.facebook.com/gcbobcats for up-to-the-minute reports, and visit www.GCBobcats.com for more information, and to nominate your favorite former Bobcats and Colonials to the GC Athletics Hall of Fame.


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David Beckham has decided he's had quite enough of not being involved in football.
Apparently, running underwear campaigns for H&M in your spare time isn't as rewarding as it seems. Anyhow, the former England man has decided to exercise an option in his contract that allows him to pick up an MLS team for a song.
A $25 million song, but then again, he's married to a Spice Girl who knows all about million dollar songs. No word yet on what the team will be called, or where it will play, or what its colours will be…or much of anything, come to think of it.
Beckham likely will take confidence in the fact that no matter what he comes up with, he can't possibly be more of a laughingstock than the Miami Marlins.
Current projections have the team joining the league for the 2017 season, pending an actual place to play. Beckham wants the city of Miami to pony up a site, and they want him to front the cash for it.
Beckham has argued that the University of Miami Hurricanes football (the American kind) team could also use the stadium, since they're having trouble selling out Sun Life Stadium.
In their defence, so are the Miami Dolphins. In fact, not even the champion Miami Heat are consistent sellouts - note the premature departure of many fans during Game 6 of the Finals last year.
So even after the stadium work outs, there still remains the question of success. This will be Miami's second foray into the MLS, the first being the ill-fated Miami Fusion, which folded twelve years ago for lack of attendance. Florida also failed to keep the Tampa Bay Mutiny in business, which begs the question: What makes this time different?
For one, Beckham stated that he want to model his new team off of the success of the Miami Heat, by bringing in some of the best players in the world. Beckham's connections to European football from his time there will surely be helpful in that endeavour, as will the recent trend of ageing pros from elite teams playing out the twilight of their careers in the US (i.e. Thierry Henry of Arsenal and the New York Red Bulls).
This plan to bring in European stars bodes well for the problem of attendance. Take, for example, the Seattle Sounders. Fronted by USA international and former Tottenham and Fulham man Clint Dempsey, the Sounders averaged an attendance last year of over 44,000 per game. This attendance was nearly on par with Chelsea FC in England, and would rank among the top of the premier league.
Unfortunately, no one can predict the future (else I'd have bet bigger on the Super Bowl), and so we football fans must wait and watch the success or failure of this new MLS team.
Write for GiveMeSport! Sign-up to the GMS Writing Academy here: https://gms.to/1a2u3KU
DISCLAIMER: This article has been written by a member of the GiveMeSport Writing Academy and does not represent the views of GiveMeSport.com or SportsNewMedia. The views and opinions expressed are solely that of the author credited at the top of this article. GiveMeSport.com and SportsNewMedia do not take any responsibility for the content of its contributors.


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Overachiever Espada true to Puerto Rican roots
Like so many growing up in Puerto Rico, Joe Espada dreamed of playing in the big leagues. He came close, reaching as high as Triple-A.
Although he never reached the highest level on the field, the game opened a door for Espada to become a Major League coach.
Like so many growing up in Puerto Rico, Joe Espada dreamed of playing in the big leagues. He came close, reaching as high as Triple-A.
Although he never reached the highest level on the field, the game opened a door for Espada to become a Major League coach.
The 38-year-old, born in Santurce, has been the Marlins' third-base coach since 2009. In his tenure, he's gained widespread respect for his work ethic and passion.
Espada is a classic example of an overachiever who achieved his big league dream, even though he never played an inning.
"I'm happy to be here, and I remind myself that it's not easy to stay here," he said. "Work ethic, go out and do the best you can every day. Don't take any day for granted, because you might not be here the next day."
The message Espada repeats to himself is also what he conveys when speaking with youngsters.
Major League Baseball is honoring Hispanic Heritage Month, and Espada is always mindful of where he came from. When it comes to promoting the game or instructing others, he is generous with his time. Frequently, Espada assists with baseball clinics in South Florida, as well as in Puerto Rico.
"In Puerto Rico, baseball is the No. 1 sport," Espada said. "It is getting better, as far as talent coming up. I remember growing up, baseball was your way of getting out. It was a way to a better life. It was a way to get you a scholarship and go to school. That's the message I try to give to the kids."
Through baseball, Espada got his education at the University of Mobile in Alabama. He maximized his opportunity, and in 1996, was a second-round Draft pick of the Oakland A's. In the Minors, he played mostly shortstop and some second base, in a professional career that lasted from 1996-2005.
As his playing days were winding down, he went into coaching, starting off as an assistant at his alma mater for a couple of seasons. Espada joined the Marlins' Minor League system in 2006.
In recent years, he's taken time in his offseason to assist some friends with baseball camps in Miami and Atlanta.
To children, Espada gives them a reality check.
"They all want to play in the big leagues," he said. "I remind them that not all of them will get an opportunity to get to the big leagues. But baseball could get you a scholarship. It could get you a four-year degree, that's for sure.
"I've had players come back to me where I did clinics, and tell me, 'Joe, I got a scholarship to a junior college.' Or they'll say, 'Joe, thank you for coming here last year and talking to us.' To me, it means a lot."
Some years, Espada has coached and managed winter ball in Puerto Rico.
His sense of obligation to give back comes from his own personal experiences. As a teenager, he recalled seeing former or current big leaguers around the youth fields, offering their insights and suggestions.
One of the big league stars of the time was Ruben Sierra, who years later was a teammate of Espada in winter ball.
"I used to see him in baseball clinics," Espada said. "He'd show up and talk to us for a few minutes."
One of the biggest coaching thrills for Espada has been coaching third base for Team Puerto Rico at the 2013 World Baseball Classic.
An underdog team from the start, Puerto Rico reached the championship before losing to the heavily favored Dominican Republic squad.
"We came together and we played incredible baseball," Espada said. "Talking to coaches in Puerto Rico and community leaders, enrollment for baseball has been huge since the WBC. Tournaments like that bring us together."
Joe Frisaro is a reporter for MLB.com. He writes a blog, called The Fish Pond. Follow him on Twitter @JoeFrisaro.


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May 2011 4Word - EditorialPosted in Features on May 1, 2011
A few years ago, during my stint at Off-Road magazine, I wrote editorials about three memorable trips to Baja California. I've received some requests to run them here in 4WD&SU, as our readership is more interested in this kind of thing. I've decided to do it. Here goes
I started visiting Baja California before I could drive. We'd go down to San Felipe with our motorcycles, unload there, and then take off on the bikes for points south. There was no paved road in the 1960s and very few inhabitants on the gulf side of Baja. In the next three issues, I'd like to relate three experiences I had south of the border that stand out in my memory. Here's the first:
A number of families decided to head south and camp on Bahia San Luis Gonzaga for a week. A few pickups would carry our supplies and the rest of us would ride motorcycles from San Felipe south. The trip down happened without incident. While we were enjoying a week of beautiful sandy beaches between Papa Fernandez' and Alfonsina's on Gonzaga Bay, a Cessna 172 came in to land on a dirt strip near the beach and nosed into a pothole, destroying its prop. Other than that excitement, we had fun on the beach and took day rides into the interior.
For the trip back, my friend Shawn Packer and I decided to race to San Felipe. I can't remember what he was riding, but I had my trusty Bultaco with an experimental leading link front fork that was too heavy but soaked up the bumps better than most forks of those days. We started back on a warm morning, with the sun glistening on the Gulf of California and the clear desert air magnifying the beauty around us. It was so beautiful that even teenagers took note. Shawn and I soon left the rest of our group far behind as we rode into the desert, heading for the mountain range that's south of Puertecitos. A misjudged turn and a spectacular crash into an arroyo allowed Shawn to blast past. By the time I got the bike back up, straightened out, and started, he was long gone. Sand and rocks roosted as I tried to catch up. I rode hard, even over The Seven Sisters, but still couldn't catch up with Shawn.
I rode into Puertecitos, which in those days was a very small fishing village with a ratty, dirt-floored Cantina and the hot spring on the hill. There was no sign of Shawn, so I cranked the throttle and headed north in a cloud of dust. The road between Puertecitos and San Felipe is paved today, with houses on the gulf and other signs of habitation along the way. Back then, there was no sign of man. Nothing but beautiful desert, white sandy beaches, and a dirt road that ranged from rocks, to dirt, to deep sand. I felt like I was the only person on Earth as I sped north. I remember cresting a divide and seeing 20 miles or more up the road as it went through a basin, then disappeared over the next ridge. In those 20 miles, I could see the long ribbon of dirt track stretching north, the deep blue gulf to the east, and no dust. None. Shawn was a good rider, but no way was he that good! I twisted the throttle to the stop as I determined to catch up with him.
Riding at top speed for hours is a good way to get tired (especially after pulling a few muscles when flying off the bike into the arroyo that morning). Even though I was young, in shape, and had a bike that was, for those days, cutting-edge, I started to feel it. The road was bad, and what was cutting-edge then would be laughably bad now. About five miles south of San Felipe, the road turned to deep, soft sand that stretched almost all the way into town. By now, I was so exhausted and hurting I was having trouble staying on the bike. I still couldn't figure out where Shawn had gone.
With San Felipe in sight, I heard a two-stroke blatting up behind me. I turned and saw Shawn, who, when he rode up, pulled off his helmet because he was laughing so hard at my attempts to keep the Bultaco headed in a straight line. Then, it was my turn to laugh as his bike gave a couple of coughs and ran out of gas. We siphoned a little out of my tank and got his bike started, and we rode the rest of the way together into town. Our group arrived more than five hours later.
It turned out that Shawn had parked behind the Cantina in Puertecitos to get a soda and had heard me blast through town, so had scrambled to get back on his bike and catch up. He didn't do it (ha!) until we were almost to San Felipe. Obviously, Shawn was faster than I was, but, that day, we both experienced the almost mystical beauty of the backcountry of Baja California by ourselves. It was quite an experience. One I'll never forget.
Experiencing the backcountry whether we're on motorcycles, quads, side-by-sides, or 4x4s is still what makes off-roading great! Next issue, Hummer H1s south of the border with Rod Hall 19 years ago, and someone we know slides off the cliff out of Mike's Sky Ranch on the road to Valle Trinidad.


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Dr. Edythe Abdullah, Mr. Luther Coggin, Mr. Wilfredo Gonzalez, Mrs. Joan Newton, Dr. Katherine Robinson, Dr. Bruce Taylor
Mrs. Toni Crawford, Mrs. Ann Hicks
Chair Taylor stated that the Committee was taking an opportunity to celebrate the accomplishments of one of UNF's outstanding students. He asked Dr. Neal Coulter, dean of the College of Computing, Engineering and Construction (CCEC), to introduce Mr. Colon.
Dean Coulter stated that Mr. Colon was a recent graduate from the Electrical Engineering program. He spoke about Mr. Colon's unique qualities and his contribution as a research assistant to the CCEC's advanced weather models for a hurricane mitigation project. Dean Coulter noted that Mr. Colon was being celebrated because he had recently accepted an employment offer from IBM Research in Yorktown, New York. He elaborated that this accomplishment was unique in that IBM Research rarely hired someone without a graduate degree. He asked Mr. Colon to say a few words to the Committee.
Mr. Colon thanked the Committee for the invitation to speak. He shared a few of his experiences at UNF and provided details about the UNF ocean buoy. He offered appreciation to the University for bringing research to the institution, noting that this opportunity prepared him to compete for the position with IBM.
On behalf of the Committee, Chair Taylor congratulated Mr. Colon on his accomplishments as a student and on is recent employment with IBM Research.
With a quorum being present, Chair Taylor called the meeting to order.
Chair Taylor asked for a MOTION to approve the minutes for May 15, 2008. The MOTION was offered by Trustee Gonzalez and seconded by Trustee Korman. The minutes were accepted as presented.
There were no comments from the public.
Chair Taylor asked Vice President Serwatka to speak about this item.
Vice President Serwatka stated that the Board of Governors (BOG) asked each institution to publish clearly defined guidelines on university centers and institutes. He clarified that the proposed new policy was in compliance with this request.
Vice President Serwatka stated that, although the institutes and centers did not award degrees, they were faculty driven. He talked about funding and listed sources as both internal and external, including the State and some general revenue dollars; however, most were funded by grants and/or contracts.
Vice President Serwatka confirmed that this proposed new policy did conform to what the BOG had requested regarding establishing, operating, evaluating, reviewing, and disbanding institutes and centers. He noted that the proposed new policy addressed periodic evaluations for institutes and centers, including a self-report and an external review process. Vice President Serwatka clarified that the University had been operating with procedures much the same as this proposed new policy.
Trustees asked if institutes and centers were required to report to the BOG. The administration stated that all institutes and centers did submit a report to the BOG annually, but the University required a more comprehensive evaluation every seven years.
Trustees asked about the significance of placing academic restrictions on the external reviewer(s). The administration clarified that current language in the proposed policy stated that the external reviewer(s) was/were required to hold the rank of Associate Professor or higher. Trustees engaged in conversation on the benefits of an interdisciplinary review panel, not limited with educational credentials.
There was consensus from trustees that language should be added to include: (1) if the Provost wishes to appoint up to two additional reviewers and (2) hold the rank of Associate Professor or higher, or hold a comparable professional position. It was noted that the previous language allowed for the Provost to appoint up to one additional reviewer.
Chair Taylor asked for a MOTION to approve the Policy on Establishing, Operating, Evaluating, Reviewing, and Disbanding University Institutes and Centers. The MOTION was offered by Trustee Robinson and seconded by Trustee Coggin. The policy was approved based on a friendly amendment to add language to include, (1) if the Provost wishes to appoint up to two additional reviewers and (2) hold the rank of Associate Professor or higher, or hold a comparable professional position.
Chair Taylor asked Provost Workman to speak on this item.
Provost Workman stated that the University's internal search for a chair for the Department of Psychology was unsuccessful, and upon reopening the search, the University found Dr. Toglia. He stated that Dr. Toglia had impressive credentials and had quickly become effective in his capacity as leader of the department.
Chair Taylor asked for a MOTION to approve tenure by reason of appointment for Dr. Michael Toglia. The MOTION was offered by Trustee Korman and seconded by Trustee Abdullah. The MOTION was accepted as presented.
Chair Taylor asked Provost Workman to speak about this item.
Provost Workman stated that the total number of new full time faculty for fall 2008 was 56. He clarified that of these 56 new hires, 53 were filling positions vacated through attrition. He noted that attrition was especially high because of the recent retirement of founding faculty.
Provost Workman listed particulars for the distribution of the new faculty across the colleges, stating that the majority were employed by the College of Arts and Sciences. He then provided details on diversity, including minority figures and degree-granting institutions. Provost Workman noted that the University was becoming more cosmopolitan with each faculty hiring cycle.
This item was informational only.
Chair Taylor asked Ms. Deb Kaye, Associate Vice President for Enrollment Services, to speak about this item.
Ms. Kaye started her discussion by noting that the University had decreased FTIC freshman enrollment by 400; with 1100 fewer students overall. She clarified that the decrease in enrollment was intentional in response to State budget cuts.
Ms. Kaye stated that official enrollment data would be available October 15th. She listed total enrollment for fall 2008 as 15,544 students, including 1,189 FTIC. She noted that there was an intentional 6.55 percent overall decrease in enrollment, including FTIC and transfer students.
Ms. Kaye stated that the intentional decrease in enrollment had positively affected the academic profile. She listed the average newly enrolled FTIC GPA for the fall 2008 semester as 3.63 and the SAT score for the same group as 1190.77. She noted that the SAT score was about 13 points higher than last year, which was significant.
The discussion continued addressing the conversion rate for the fall 2008 freshman class. Ms. Kaye stated that this rate was gathered from data that included the number of students who applied, who were admitted and who ultimately enrolled. She clarified that the conversion rate had gone down because the institution was becoming more selective.
Ms. Kaye discussed the Presidential Scholarship Awards, including the influence from decreased FTIC. She noted that, although overall matriculation was down, the rate of students achieving the award was up. She attributed this to the University's ability to recruit higher achieving students.
Ms. Kaye mentioned that data from fall 2008 showed a slight decline in geographic diversity. She clarified that this decline was an indicator of the weak economy's affect on student moving outside the Crown Region (Baker, Bradford, Clay, Columbia, Duval, Nassau, Putnam, St. Johns).
Ms. Kaye stated that there was a slight increase in minority enrollment. She listed the fall 2008 minority enrollment as 22.27 percent and spoke about the positive influence of the Jacksonville Commitment.
Ms. Kaye stated that the University was excited to have enrolled 40 new students through the Jacksonville Commitment program. She noted that in-school counselors were not in place yet but the University had employed an extremely competent director.
Ms. Kaye discussed the Florida Bright Futures Scholarship program, noting that 80.3 percent of FTIC students enrolled in fall 2008 were recipients.
The Presidential Scholarship awards were discussed noting that, in order to accommodate budget shortfalls, this program was revised for the 2008 recruiting year and the results were significant. She explained that a total of 155 scholars were matriculated for the 2008-2009 academic year – with a total of $387,500 scholarships being awarded. Ms. Kaye stated that 95 percent of these scholarship recipients were retained from the sophomore year, as compared to 75 percent of the general population.
Ms. Kaye presented details on how the University worked with historical trends to meet enrollment targets. She commented that there was a change last year, in that once students were matriculated, they were remaining at UNF. She noted that the Presidential Scholarships were a means to retain students and the new Roadmaps initiative would also contribute to retention.
Ms. Kaye talked about the decline in transfer applications and matriculation of these students. President Delaney stated that this would be a topic for the upcoming workshop.
The administration stated that the institution's vision for UNF was to increase enrollment to 25,000 students. It was mentioned that the time to address this was now, with full consideration being given to financial mandates. Trustees stated that the Board and the University leadership should come to consensus on where UNF was headed and how to get there, while remaining cognizant that the University could not be all things to all people.
Provost Workman stated that the University should not assume that the student profile would be sustained with growth. And if/when enrollment was increased, the University needed to anticipate that selectivity would decline – at least for a while. Chair Taylor stated that access versus enrollment would be a topic at an upcoming workshop.
Ms. Kaye spoke about a decade of change and noted that all statistics represented growth. She stated that the goals for the upcoming year, pending funding, would be to enroll 1400 FTIC for fall 2009, with goals for a 3.7 GPA and 1200 SAT.
Ms. Kaye talked about scholarship programs and noted most students were on some kind of financial aid. She clarified that the condition of the economy made it critical that this trend continue.
Ms. Kaye stated that student loan amounts were increasing at an alarming rate. She reported that students were required to go through entrance and exit interviews where they were provided information about securing student loans and repayment of these loans. She clarified that counselors were encouraging students to access as much free money as possible.
Ms. Kaye provided an update on the Jacksonville Commitment program and mentioned that the first 6 scholarships were awarded for summer 2008, with these recipients returning for fall 2008 to form a class of 37 scholars. She stated that these students had an assigned academic advisor and a financial aid coordinator to mentor, assist, and advise them throughout their years at UNF.
This item was for information/discussion only. No further action was required.
President Delaney stated that the University was progressing toward the February 2009 deadline for SACS with no evident difficulties.
Chair Taylor adjourned the meeting.


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==Current Needs of This Project==
==Current Needs of This Project==
This section describes the current To Do list for this project, and can be changed frequently. Data for the project will be accumulated in lower sections of this page. It
This section describes the current To Do list for this project, and can be changed frequently. Data for the project will be accumulated in lower sections of this page. It possible to comment/alter this page directly with an OpenWetWare account. Other venues for commenting/suggesting are [https://plus.google.com/u/0/b/114702323662314783325/114702323662314783325/posts G+], [http://www.thesynapticleap.org/malaria/community The Synaptic Leap], [https://twitter.com/OSDDMalaria Twitter] or the Lab Notebooks for the [http://malaria.ourexperiment.org/aminotpseries chemistry] or the [http://malaria.ourexperiment.org/biological_data biology].
==Data on the Intial Hit==
==Data on the Intial Hit==
The original hit compound, [https://www.ebi.ac.uk/chemblntd/compound/results/9372/1/molweight/asc/mini
The original hit compound, [https://www.ebi.ac.uk/chemblntd/compound/results/9372/1/molweight/asc/mini TCMDC 135294], has the following structure:
[[Image:thienopyrimidine.PNG|thumb|center|180px|GSK Thienopyrimidine Series: TCMDC 135294]]
[[Image:thienopyrimidine.PNG|thumb|center|180px|GSK Thienopyrimidine Series: TCMDC 135294]]
. . .
[https://www.chemspider.com/Chemical-Structure.24575349.html?rid=a5689148-4b7f-4b14-b9e6-7d03c39148df ChemSpider].
SMILES: Nc1ncnc2cc(sc12)c3cccc(c3)S(=O)(=O)N
SMILES: Nc1ncnc2cc(sc12)c3cccc(c3)S(=O)(=O)N
==Existing Analogs==
==Existing Analogs==
|Line 85:
|Line 132:
===Construction of the thienopyrimidine scaffold===
===Construction of the thienopyrimidine scaffold===
It was found that the desired ring closure of formamide and methyl 3-aminothiophene-2-carboxylate could not proceed in the conditions tested. This ring closure was instead carried out using formic acid and ammonium formate in lieu of formamide. Steps 2 and 3 proceeded without controversy to give the aminothienopyrimidine scaffold.
It was found that the desired ring closure of formamide and methyl 3-aminothiophene-2-carboxylate could not proceed in the conditions tested. This ring closure was instead carried out using formic acid and ammonium formate in lieu of formamide. Steps 2 and 3 proceeded without controversy to give the aminothienopyrimidine scaffold.
===Completion of the halogenated aminothienopyrimidine scaffold===
===Completion of the halogenated aminothienopyrimidine scaffold===
Revision as of 20:00, 23 June 2013
- 1 OSDD Malaria Series 2: The Aminothienopyrimidine (ATP) Series
- 1.1 Introduction
- 1.2 Current Needs of This Project
- 1.3 Data on the Intial Hit
- 1.4 Existing Analogs
- 1.5 Experimental Work
- 1.5.1 Biological Evaluation
- 1.5.2 Organic Synthesis
- 1.5.3 Construction of the thienopyrimidine scaffold
- 1.5.4 Completion of the halogenated aminothienopyrimidine scaffold
- 1.5.5 Generation of the Boronate Ester
- 1.5.6 Analogs
- 1.5.7 References
OSDD Malaria Series 2: The Aminothienopyrimidine (ATP) Series
This page describes a sub-project of the Open Source Drug Discovery for Malaria consortium. Background to how the project works can be found on the page that describes the first branch of the project: OSDDMalaria:Story so far.
All experimental work in this branch of the project is described on an open lab book; status updates for the project are posted on The Synaptic Leap website, for example here; and some discussions take place on the consortium's Google+ page and Twitter feed, which may be followed. All contributions are welcome, ideally in the public domain, though existing members may be contacted offline if absolutely necessary e.g. at User:Matthew Todd.
The Origin of this Antimalarial Drug Candidate and the Project's Approach
In 2010, GlaxoSmithKline (GSK) released chemical and biological data pertaining to some 13,500 compounds that displayed potent antimalarial activity in vitro (Nature paper). Medicinal chemists at the Medicines for Malaria Venture (MMV) identified several compounds present in this dataset which they believed to be excellent hits. These two compounds had the combination of a drug-like profile (polar, low molecular weight, amenable to structural variation), high potency, low cytotoxicity, no known intellectual property issues, and to the best of their knowledge they were not the subject of antimalarial research by any other group, and hence suitable for an open source project.
This page details the development of one of these two compounds, based on an aminothienopyrimidine core. MMV has developed a set of compound progression criteria and these should be used to inform the project.
The high throughput nature of the GSK screen carries the possibility of a false positive, and thus the first step was to resynthesise the hit compound and confirm its antimalarial activity. To see if the compound could be further optimised, the next step would be the synthesis of small sets of diverse analogs, as well as some exploration of the druggability (solubility, metabolic degradation etc) of the hit compound. If an interesting structure-activity relationship could be found, the compound might be suitable for lead optimisation.
Current Needs of This Project
This section describes the current To Do list for this project, and can be changed frequently. Data for the project will be accumulated in lower sections of this page. It is possible to comment/alter this page directly with an OpenWetWare account. Other venues for commenting/suggesting are G+, The Synaptic Leap, Twitter or the Lab Notebooks for the chemistry or the biology.
Guiding Principles:
1) Maintain low calculated logP values for suggested compounds (<5)
2) Be mindful of molecular weight
3) Aim for diversity, given OSM-S-106 arose from a phenotypic screen and has no known target/mechanism of action
4) That there must be a reason for doing chemistry: Can analogs be obtained by other means, from other groups? Is the original hit the best compound?
See May 2013 consultation for most recent open consultation on ATP analogues to target.
Latest round of biological evaluation here. Compound structures governed by what was accessible synthetically in the short term, in particular by what boronic acids could be made/bought.
Results: All changes had seriously deleterious effect on activity. Meta sulfonamide appears necessary for activity. Morpholine is a poor replacement for amine. Results for OSM-S-137 vs TCMDC 132385 (structures here suggest that variation of amine is possible where there is some variation (i.e. removal) in the sulfonamide portion. Raises possibility that there might be two targets - one hit by the substituted pyrimidine and one by the aryl sulfonamide.
Rationale for structures: Morpholine substitution was thought to have been sensible based on this modelling analysis. Longer side chain attached to amine in OSM-S-137 was proposed because of mild activity for TCMDC 132385 (again, comparison here).
Solubility: In several cases there appeared to be some sort of solubility issues, though we had expected all these compounds to be highly soluble.
Short term TO DO items:
1. Morpholine group appears to be a bad substitution. Make other substitutions on the primary amine, such as one or two methyls (dimethyl InChIKey CGTVWFYTOADSRO-UHFFFAOYSA-N). Route to that would likely be to take OSM-S-70, add dimethylamine, then brominate, then Suzuki. Action item for Althea.
2. How many more meta-substituted sulfonamides like OSM-S-106 exist in the literature? We've done this search before (link?), but let's revisit. Action item for Alice.
Answer: There are 59 commercially available meta-substituted boronic acid/esters from Boron Molecular as shown here.
3. We already ordered several other meta-substituted boronic acids, 10, 15 and 55 - ([1]), some of which have now come in (10 (OSM-S-135) and 15 (OSM-S-133) already synthesised and tested [2]). We need to evaluate these. Action item on Althea.
4. Are there any doubly-substituted meta-boronic acids we could employ in the coupling? Action item on Alice.
Answer: There are a few doubly-substituted meta-boronic acids/esters available from Sigma Aldrich as shown here.
5. TCMDC-132385 should be synthesised to check its activity, as well as the fragments without the fluoroaromatic, and with other aryls. Action item on Murray.
6. Ask GSK for any information they might have on known inactives around OSM-S-106 where there is variation in that pendant amine side chain. Action item on Mat.
7. Make OSM-S-106 with substitution of the amine with a methyl ether (InChIKey RMRWXSBDYMDPPE-UHFFFAOYSA-N). Devise synthetic approach. Action item on Alice.
8. Approach Sue Charman's lab for solubility and metabolic assays on OSM-S-106. Action item on Mat.
Longer term items:
1. Synthesise des-amino OSM-S-106 (NAPAWLMTRGMNSY-UHFFFAOYSA-N), i.e. substitute the amine for H on the pyrimidine. Who wants to do this?
2. Can OSM-S-106 be derivatised further, i.e. this compound as a starting point?
3. Can Murray's new bromo-regioisomer synthesis be used to make more diverse compounds. How risky is this in terms of the amount of methodology needed?
4. How easily can scaffold analogs of OSM-S-106 be accessed, e.g. furan (GSJDJXHDXORRDD-UHFFFAOYSA-N), flipped thiophene (NBFDNDWQCGJNHN-UHFFFAOYSA-N), pyrrole (XTMBLMGMAYOFBP-UHFFFAOYSA-N), indole (ZVHBDXVFFFLUQY-UHFFFAOYSA-N), pyridine vs pyrimidine (FCEYCXXGTFVWIS-UHFFFAOYSA-N)?
5. Order a selection of meta-substituted boronic acids/esters (based on May 2013 consultation ) to make some more thienopyrimidine analogues.
6. Synthesise some analogues containing sulfonamide bioisosteres such as sulfonimidamides. Inspired by this publication: DOI: 10.1002/cmdc.201200014.
Data on the Intial Hit
The original hit compound, TCMDC 135294, has the following structure:
This compound has attractive ALogP and molecular weight values. In the OSDD project it has the ID OSM-S-106. Its biological activity has been confirmed (see below).
Other instances of this compound:
Machine-readable data:
SMILES: Nc1ncnc2cc(sc12)c3cccc(c3)S(=O)(=O)N
Existing Analogs
If analogs of these compounds already exist, they should be explored.
In TCAMS Data Set
Need: Analysis and data associated with other relevant compounds in the GSK TCAMS data set.
An analysis of which commercially-available compounds are available has been done, and several compounds purchased and evaluated.
Need: The availability of compounds changes quite often, and searches should be periodically carried out.
Other Sources (e.g. Academic Labs)
If promising-looking analogs are available from other sources, we can contact the owners and arrange local screening for activity. Post details here:
Need: Find owners of relevant compounds, and indicate whether they have been contacted.
Experimental Work
Biological Evaluation
Activity of initial hit: February 2013
Activity of commercial analogs of initial hit: Structures: October 2012, Activity: November 2012
Activity of synthesised analogs:
Small Fragments: October 2012 First Major Analog Set: April 2013
Organic Synthesis
A proposed synthesis for this hit compound was drawn up, and is shown below:
It was envisioned that the hit compound could be generated using this convergent strategy. The thienopyrimidine scaffold was to be synthesised from the commercially available formamide and methyl 3-aminothiophene-2-carboxylate. The use of trivial heterocyclic chemistry was thought to be sufficient for the introduction of an amine at the 4-position of this scaffold, before the substitution at the 6-position by a halogen was to proceed using lithiation/halogenation. Meanwhile, the benzenesulfonamide moiety was to be generated by transforming the commercially available 3-bromobenzenesulfonamide into the relevant boronate ester. The thienopyrimidine scaffold (A) and benzenesulfonamide boronate ester (B) would then be united using a Suzuki coupling.
The results of this synthetic effort are described hereinafter.
Construction of the thienopyrimidine scaffold
It was found that the desired ring closure of formamide and methyl 3-aminothiophene-2-carboxylate could not proceed in the conditions tested. This ring closure was instead carried out using formic acid and ammonium formate in lieu of formamide. Steps 2 and 3 (above) proceeded without controversy to give the aminothienopyrimidine scaffold.
Updated synthetic information of chlorinated scaffold:
Links to synthesis of central chlorinated scaffold:
Starting material for this synthesis costs $226 per 25g (from?). The 4-chlorothienopyrimidine product is available from Acros for $293 per 25 g. *Given this, do we just buy it?* Or should we request some from an interested company as a contribution?
Links: http://malaria.ourexperiment.org/uri/2a4 and http://malaria.ourexperiment.org/uri/2a6
Completion of the halogenated aminothienopyrimidine scaffold
Substitution at the 6-position of this aminothienopyrimidine scaffold could not - in our experience - be carried out. Protection of the free amine at the 4-position was found to be a successful strategy for introducing the halogen at the 6-position, however, this method gave low yields. Using the chlorinated thienopyrimidone (X) in a lithiation/halogenation was found to be the most synthetically tractable way of introducing the desired functionality whilst maintaining workable yields (~50%). An amine was introduced at the 4-position using ammonium hydroxide solution in a sealed tube (120 °C).
Alternative Synthetic Strategies
The step that involves n-BuLi would best be avoided, and if a more direct route of arriving at the Suzuki coupling step could be discovered, that would take a potentially dangerous and difficult step out of the synthetic route.
One possibility, involving NIS and an ionic liquid such as 1-Butyl-3-methylimidazolium tetrafluoroborate (which our lab doesn't have, but which is available from Aldrich in catalytic quality from $247/5g), is found below:
[doi:10.1016/j.tetlet.2011.03.010 DOI]
[dx.doi.org/10.1139/V09-125 Here] is another alternative, where the direct iodonation of arenes can be carried out using oxone and NaI. Whether or not this would work in my compound, given selectivity issues, is something that I'll have to investigate.
This paper shows a method of direct halogenation of thiophenes. This uses [Bis(trifluoroacetoxy)iodo]benzene, which we don't have lying around, but which can be bought from Aldrich for $136/10g. The reactivity of thiophenes vs pyrimidines is something I'll have to look into. UPDATE: I've read Clayden et al. (2012, p 727) and I'm informed that pyridine is, generally speaking, terrible at electrophilic aromatic substitution reactions. My understanding is that pyrimidine has the same reactivity as does pyridine, so there shouldn't be any selectivity problems with any of these reactions (a result that was perhaps anticipated by the BuLi reaction proceeding at the alpha position on the thiophene ring in the first place).
--- July 9th.
The BuLi reactions have literature precedent. Heffron (2010) acheives a very similar reaction, albeit with protection of a pyrimidine position (which doesn't seem to be reacting in my case anyway). Snegaroff (2009) uses (TMP)3CdLi to acheive the metallation/iodination. This less harsh base can be used at rt. This author discovered the reagent, so they are probably interested in self promotion. In any case, there is precedent for the lithium metallation proceeding.
--- July 18th
A post on ChemForums suggested that the sulfur might react with the iodine. According to Joule & Mills (p. 234) this won't happen. "The five membered heterocycles do not react with electrophiles at the heteroatom." and "...in pyrrole, electrophilic addition at the nitroge would lead to a substantial loss of resonance stabilisation - the molecule would be converted into a cyclic butadiene, with an attached nitrogen carrying a positive charge localised on that nitrogen atom.
--- August 26
A search performed on SciFinder at 8:57pm revealed that the meta sulfonamide is NOT novel.
Generation of the Boronate Ester
Initially, the synthesis of a boronic acid was desired however, this could not be generated on these substrates. Instead, boronate esters were generated for the para- and meta-substituted boronate esters of interest.
Thiophene Starting Material Synthesis
Additionally, the thiophene available from Sigma Aldrich for $159/10g can be made from the following synthesis.
TCMDC 135294 is part of a series with one other member, | TCMDC 135255, shown below:
| ChEMBL639249 link.
| ChemSpider link.
SMILES: Nc1ncnc2cc(sc12)c3cccc(NC(=O)Nc4ccccc4)c3
A list of commercially available compounds with similar structures to the one I'm trying to synthesise were identified with much help from Iain Wallace. If you're reading this and are interested in donating samples of these compounds, please contact someone on the project.
Misc possible industry sources of compounds:
- Boehringer thienopyridines. Contacted. Need other way in!
- Southern Research Institute. Contacted April 1 2013. Replied April 2 to say they did not have the compounds available.
Iain Wallace created a cytoscape file which details purchaseable compounds related to the two series that I am trying to make. The file can be found here, and Cytoscape can be downloaded for free here (one will need to activate the chemviz plugin, which can be activated from within Cytoscape). The results of this work, in the form of a list of purchaseable compounds, can be found here
A list of the above compounds in .csv format, with InChi, InChiKey, SMILES and eMolecules identifiers, can be found here.
These compounds, and relevant data, are shown below:
Two compounds have since become unavailable from Enamine. These are commercially available but with a less strict similarity search on emolecules. http://www.emolecules.com/cgi-bin/rene/visitor.cgi?h=c22c97319d83c434da71f7f53149d7d2aaf0fe3014125ab4
Synthesis of new analogues
This image presents some strategies for assessing SAR's on the aminothienopyrimidine core.
Honours Thesis by Jimmy Cronshaw (submitted and examined) entitled "Open Source Drug Discovery: Effort Toward the Synthesis and Evaluation of Two Antimalarial Drug Candidates" may be downloaded from Figshare. The thesis is in PDF form, but contains much of the early data on this page.
Barker, J. M.; Huddleston, P. R.; Wood, M. L., A RAPID CONVERSION OF 3-OXOTHIOLANES INTO 3-AMINOTHIOPHENES. Synthetic Communications 2002, 32 (16), 2565-2568.
Baykal, A. T.; Kakalis, L.; Jordan, F., Electronic and nuclear magnetic resonance spectroscopic features of the 1 ',4 '-iminopyrimidine tautomeric form of thiamin diphosphate, a novel intermediate on enzymes requiring this coenzyme. Biochemistry 2006, 45 (24), 7522-7528.
Brown, G. B.; Baker, B. R.; Bernstein, S.; Safir, S. R., BIOTIN. II. 3,4-trans-DIAMINOTHIOPHANE. The Journal of Organic Chemistry 1947, 12 (1), 155-159.
Castenado, G.; Dotson, J.; Goldsmith, R.; Gunzo, J.; Heffron, T.; Mathieu, S.; Oliveo, A.; Staben, S.; Sutherlin, D.P.; Tsui, V.; Wang, S.; Zhu, B.; Bayliss, T.; Chuckowree, I.; Folkes, A.; Wan, N.C. (Genentech, Inc., USA; Piramed Limited). Thienopyrimidine and furopyrimidine derivatives as phosphoinositide 3-kinase inhibitor and their preparation, pharmaceutical compositions and use in the treatment of cancer. World Intellectual Property Organisation 2008073785 A2, 2008; SciFinder Scholar AN 2008:735944 (accessed 2/2/2012).
Diel, B. N.; Han, M. C.; Kole, P. L.; Boaz, D. B., Synthesis of (C-13(6)-Ring-(U))-(+/-)-benzo(a)pyrene metabolites from (C-13(6)-Ring-(U))benzene. Journal of Labelled Compounds & Radiopharmaceuticals 2007, 50 (5-6), 551-553.
F, Duus., A study of the tautomerism of 2- and 4-ethoxycarbonylthiolan-3-ones implicating stereochemical effects of ring-substitution. Tetrahedron 1981, 37 (15), 2633-2640.
Son, J.B.; Jung, S. H.; Choi, W.I.; Jung, Y.H.; Choi, J.Y.; Song, J.Y.; Lee, K.H.; Lee, J.C.; Kim, E.Y.; Ahn, Y.G.; Kim, M.S.; Choi, HG.; Sim, T.B.; Ham, Y.J.; Park, D.; Kim, H.; Kim, D. (Hanmi Holdings Co., Ltd., S. Korea; Korea Institute of Science and Technology; Catholic University Industry Academic Cooperation Foundation). Preparation of thienopyrimidine derivatives for use as protein kinase inhibitors. World Intellectual Property Organisation 2011093684 A2, 2011; SciFinder Scholar AN 2011:971406 (accessed 3/2/2012).
Woodward, R. B.; Eastman, R. H., Tetrahydrothiophene ("Thiophane") Derivatives. J. Am. Chem. Soc. 1946, 68 (11), 2229-2235.


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AccuWeather.com reports wheat growers in India expect this year's harvest to surpass last year's record crop, and a near-normal rainfall forecast for monsoon season is good news for other agriculture.
Analysts in India, the second largest producer of wheat, expect the country to produce 82 million tonnes during the 2009-2010 harvest, which is up from 80.68 million tonnes last year.
AccuWeather.com meteorologists said that March yielded some of the warmest temperatures on record for many regions in India. However, it appears the wheat crop was far enough along not to be affected by the record warmth.
Premature ripening as a result of the heat could cause high production yields to be eased, but early harvests already show local stockpiles having as much as four times the minimum needed to cope with emergencies.
As of April 21, government agencies in India have already purchased 15.26 million tonnes of wheat in comparison to 13.89 million last year, according to Reuters.
Analysts in India also said the monsoon forecast release, accompanied by record inventories, limited buying futures on wheat purchases as of late.
Historically, food prices fall when a favorable monsoon forecast is released.
The India Meteorological Department's monsoon forecast calls for near-normal seasonal rainfall for June through September, 2010, according to IMD's head meteorologist.
The forecaster at that time said that last year's deficient summer rain, the lowest in 37 years, was unlikely to recur. The outlook is based in part on supercomputer numerical modeling, together with the consideration that one bad rain year is rarely followed by another.


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The year 2012 was a celebratory one for Atlantic Beach resident Richard Brodsky as he marked two anniversaries: surviving HIV after 15 years and brain cancer after a decade.
Brodsky had a difficult decision to make in August 1997 after he was diagnosed with HIV. "I love my wife a lot and having to tell her this was very difficult," he said. "I had three choices; I could kill myself, but I couldn't do that because of my three daughters, my wife and I could get a divorce and I would move out or we could stick together and work things out."
Brodsky, a Lawrence High School graduate, met his wife of 32 years, Jodi, on a blind running date in Houston, Texas. "She was very loving and wanted it to work out," he said.
Jodi was shocked when her husband told her he was HIV positive. "We were not so aware of how you could contract HIV, and he was my best friend," she said. "I knew immediately that we would stay together and try to work this out."
In 2002, Brodsky wrote a book about his relationship with his wife called, "Jodi: The Greatest Love Story Ever Told." While on a book tour in November that year, he suffered a seizure. He was diagnosed with terminal brain cancer and was told he had between two to four years to live. "It was a terribly depressing and difficult time," Brodsky said. "But a year later I ran the New York City marathon and at a certain point I felt like I would beat this thing."
Running, Brodsky believes, is the reason he's in such good health. To date, he has run 39 marathons and in Oct. 2012, he ran his fastest marathon in Hartford, Conn. in four hours and six minutes. "Before I turn 65, I'd like to run a marathon in under four hours," said the 60-year-old. "But I think I'll do it before 65."
Every year, for the past seven years, the Brodsky's have been travelling to Kenya to celebrate World AIDS Day on Dec. 1. They have sponsored several orphan dinner dances for more than 4,300 orphans and run in the Kisumu World AIDS Marathon. "I love going there because it gives me a good feeling and the orphans enjoy seeing us," he said. "If I wasn't doing this, I don't know if I'd be alive. It gives me a sense of purpose."
Garden City-based pediatrician Dr. Richard Satori has been travelling to Africa with the Brodsky's for the past two years and has helped more than 130 children in two of the country's orphanages. "We bought medication to help treat the children," he said. "I felt there was a need and if there was something I could do to make a dent, I was going to do it. I've come to the conclusion that I can't change the world but I felt that we as individuals could make a dent."
Following a suggestion from his brain oncologist, Brodsky established the Richard M. Brodsky Foundation in 2004 to help raise awareness about HIV testing and to serve as hope for others those living with HIV and cancer. The foundation has raised about $180,000 since its inception and has provided financial assistance to several local organizations such as the Five Towns Community Chest and 1 in 9 Hewlett House as well as hosted several running events each year throughout Nassau County, including in Cedar Creek Park in Seaford and Oceanside Park. "We need to continue to raise awareness so people get tested for HIV," he said. "And I just want to be able to donate more money when we can."
Despite the challenges he has faced in his life, Brodsky said he is grateful. "I'm very fortunate to have a loving wife and it feels great to be able to help people," he said. "It feels like a million dollars to still be living and I cherish each day."
Jodi hopes her husband's foundation will continue to flourish and that he remains healthy. She is also looking forward to running in the ING Miami Marathon on Jan. 27. "Running has been a big part of our lives and I think Richard's good health is attributed to his being able to feel that he is helping others," she said. "We live our lives that it's not a question as to whether the glass is half full or half empty; for us it is overflowing."
For information on Brodsky's foundation and how to help, visit www.richardmbrodsky.org


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William E. Rapfogel, Executive Director and Chief Executive Officer of the Metropolitan Council on Jewish Poverty (Met Council) since 1992, has been fired from his job and is under investigation for alleged financial wrongdoing, the NY Times reported.
Attorney General Eric T. Schneiderman, and comptroller, Thomas P. DiNapoli, are now investigating Mr. Rapfogel as part of a new anti-corruption task force.
In a statement released by his lawyer, Rapfogel apologized for unspecified mistakes.
"After 21 years at the Metropolitan Council on Jewish Poverty, I deeply regret the mistakes I have made that have led to my departure from the organization," he said. "I apologize to our dedicated officers and board, our incredible staff and those who depend on Met Council. I let them all down."
Rapfogel also said: "I pray that my family and friends and all who care about Met Council can find it in their heart to forgive me for my actions. I will do everything possible to make amends."
Met Council released the following statement:
"The Board of Directors of Met Council recently became aware of specific information regarding financial irregularities and apparent misconduct in connection with the organization's insurance policies. The Board retained outside counsel to conduct a full investigation. Based on that investigation, which is ongoing, the Board has terminated Mr. Rapfogel, effective immediately, and notified the proper authority. To date, the investigation has not revealed evidence that any current employees of Met Council engaged in any wrongdoing.
"The Board takes these matters very seriously. For over forty years, Met Council has been a respected leader as one of New York City's largest human services agencies, providing assistance to over 100,000 New Yorkers each year in their fight against poverty. The Board is committed to ensuring Met Council's operations are conducted with integrity and that they uphold our highest values.
"The Board has embarked upon a search to identify a new CEO and will work diligently to appoint a replacement as quickly as possible. In the meantime, there should be no disruption to Met Council's day-to-day operations. The Board has the utmost confidence in the talent and dedication of the current executive staff, which will continue to manage the organization's various programs that provide food, shelter and care to thousands of New Yorkers in need."
In 2011, the Met Council paid Mr. Rapfogel $340,089 in direct compensation, plus $77,202 in "other compensation," according to a tax document filed with the Internal Revenue Service, the Times reported.


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I have long been a skeptic when it comes to governments and companies hiding behind confidentiality clauses to evade public scrutiny of government purchases, for example through public-private partnership agreements.
While it is theoretically possible that a government could negotiate a lower price if kept confidential, in practice confidentiality is used because to inflate payments to the private sector from the taxpayer. If the government got a good price, do you think they wouldn't be boasting about it?
We now discover that license payments to Bernie Ecclestone's Formula One Grand Prix amount to around $170 million in the five years to 2015. No wonder it has been kept confidential by four premiers.
It is unacceptable that such contracts be hidden from public scrutiny. Only full transparency can provide some discipline on governments to adopt prudent expenditure policies. Governments should also be required to provide a full and transparent cost-benefit analysis to justify decisions to subsidise such events. If such analysis shows a net cost, then the government should provide a justification for funding a project where the costs exceed the benefits.
What has Bernie Ecclestone ever done for Australia?


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July 14, 2018 9:00 am to July 14, 2018 11:00 am Save to calendar
Categories: Diabetes Care
- Session 1 is July 14, 2018, from 9 am to 11 am.
- Session 2 is July 28, 2018, from 9 am to 11 am.
Prediabetes is a condition in which a person's blood sugar levels are higher than normal, but not high enough to be diagnosed as diabetes. Left unchecked, this condition often leads to type 2 diabetes – a lifelong disease.
This program is designed for a person who has a family history of diabetes, a person diagnosed with prediabetes or a person who would like more information about decreasing their risk of getting type 2 diabetes.
Studies have shown that you can decrease your risk of getting type 2 diabetes by 58 percent by making some healthy lifestyle changes. The Diabetes Prevention Program will give you information and support to make these behavior changes.
The program includes information on:
This is a four-hour program split into two sessions. A loaner blood sugar meter and instructions on how to use the meter are included in this program. You are encouraged to bring a support person at no extra charge. If your support person would like to participate and receive class materials, the class fee would apply to them also.
The cost of the class is $35. Financial assistance is available.
Questions? Call HealthEast Diabetes Care at 651-232-5757.
Please arrive 10 minutes early for the first session to receive your class materials.
You are currently using an outdated browser.
The new HealthEast web site was built using the latest technology for improved features and to allow mobile access. This requires a modern browser for the best experience in layout and functionality. The browsers at HealthEast are outdated because of requirements for clinical applications. You can still click вЂclose' and browse the site with an outdated browser, however, it will not display correctly or support all features. We recommend you either upgrade your browser at home, or view the site with a mobile device. We apologize for this inconvenience.on


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the sponsors of this bill are named Todd, Rob, and Dan. Todd was kind enough to state that women won't be forced to watch the ultrasound. well, isn't that nice. i'm glad they won't be propping up women's eyelids with toothpicks while sticking her face in the computer screen. i guess that would be too Clockwork Orange of them.
you'd think that these states would learn. take a look at what happened in Virginia. women freak out over these issues, as they should. yet here we go again, with GOP lawmakers seizing their opportunity to power grab over their female constituents. Todd thinks this is just common sense. well, if that's the case then i'm sure that the woman and her doctor will figure things out on their own. there's no need to legislate this.
and if these bills are really no big deal, as many claim them to be, then why are they bothering in the first place? what's the agenda?
"It's really just to help women make a good and informed decision, and if they seek an abortion afterward, that is absolutely their right and ability to do so,"
i'm sorry, but what information are they providing? maybe it's for women who have multiple abortions so they can start a scrap book.
what this bill, and all of these types of bills for that matter, is doing is to shame and guilt women into carrying their baby to term. there is no other agenda. this isn't about providing information, it's about making an already difficult process that much more difficult. please, for the love of your God, leave these women alone!
Views: 228
Texas passed the Ultrasound bill unfortunately.
it hasn't passed yet. it still has to make it through the House. which i'm sure it will.
a couple of real doozies in your linked article:
Republican Gov. Rick Perry, who had put the legislation on a fast track by declaring it an emergency priority, commended the bill's advancement.
"This is God's time to pass this bill," said the measure's author, Sen. Dan Patrick, a Houston Republican.
emergency priority?????? i guess he's conceding the fact of war on vaginas. i mean, if it's an emergency this must be war, right?
God's time? if he thinks so, i'd like to hear him say it. you shouldn't be speaking for God (blasphemy?). he's a big boy (the biggest i suppose) and i think he can speak for himself. what's that? he can't speak directly to all of us? just a few of you? oh, that's slick of him. sounds like a fucking wussy if you ask me.
I agree with you that these bills are heinous. I do want to take you to task, a little, for the first line - it sounds like support for invasive anti-abortion bills are all-male. In the article, it states "introduced by Rep. Kathy Rapp, R-Warren.", and there are many, many women who are highly active in the anti-abortion movement. It may indeed be a way to control women's lives and bodies, and it may be mostly men doing it, but there are also highly influential, well known women involved in this and other christianization efforts as well. The recent Komen-foundation, anti-planned parenthood debacle is an example - highly influential women who are fighting against women's rights even while ostensibly promoting women's health.
i get that. and i'm aware that the sponsor of the VA personhood bill is a woman as well. i think that's the strategy though. find one woman will will support it, get her to introduce the legislation, and let the men do the heavy lifting. but b/c it wasn't introduced by a man it helps to curb public criticism.
a petition is going around, with nearly 10,000 signatures already. linked below:
add Illinois to the list. most troubling is that in Illinois, the Ultrasound Bill was promoted by the state's Agricultural Committee. chattle, indeed.
The sign-on.org petition is now almost to 20,000 (their goal).
I too am from PA, and I am thoroughly ashamed that this bill would even be proposed in our state. The comment that I left on the petition site is that even though the proposers of the bill say that the trans-vaginal ultrasound will not be a requirement (could also be trans-abdominal), the stipulation that a reasonably clear image (my wording) be presented to the doctor performing the abortion will undoubtedly make the trans-vaginal ultrasound almost mandatory. For women who don't want the trans-vaginal ultrasound, what they must ultimately submit to is a form of institutional rape, or they won't be able to get an abortion.
Women are already well aware of what the end result of the abortion process is. They don't need "big brother" trying to coerce them through feelings of guilt or shame. This ultrasound process is just another unneeded "hoop" for women to jump through to get an abortion. It's a waste of time and resources for both the women and the health care providers.
P.S. I spoke with my wife and my daughter about this bill, and they both describe the trans-vaginal ultrasound as both invasive and extremely uncomfortable. I think women's knowledge of this procedure is just one more point that the bills sponsors are counting on.
a good article on this issue. what's scary is the comments (fortunately there aren't many). how anyone can see the flip side of this coin is beyond me. the same people who support fetus rights are likely the ones who would gladly club a baby seal if the opportunity presented itself.
"hey baby seal, stop eating our fish!!" (whack!)
in Kansas, doctors would be able to lie to their patients about potential deformaties or other anomolies if they think it might cause the woman to abort. the state's Governor, whom i will now call Mr. Due Dilligence, has already said he will sign the bill if it passes, even though HE HASN'T READ IT YET!
so let me get this straight: if an anti-abortion bill was put on his desk that called for keeping the would be "murderer" imprisoned for 8 months so she couldn't abort, he would sign it? i'm beginning to think he would.
great news. the bill has been squashed!
Women are going to start attacking the males of the rightwing... but they are well protected by fools so...
eat that one.
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October 2009, Volume 1, Issue 10
Check your Fall Calendars!
YARP Voting Begins
Oct. 18
Teen Read Week
Oct. 18-24
National Friends of Libraries Week
Oct. 18-24
National Novel Writing Month
National Gaming Day @ your library
Nov. 14
American Education Week
Nov. 15-21
Letters for Literature
Dec. 12 deadline
Cornerstone SurveyShare your opinions of the Cornerstone Newsletter in this quick survey!
Featured e-Resource of the MonthWorldCat Expands!
Welcome to the Cornerstone Archives. Find the current newsletter at sdslcornertsone.blogspot.com.
Welcome to the Cornerstone Archives. Find the current newsletter at sdslcornertsone.blogspot.com.
In this month's issue
- Brookings Public Library has very good friends
- What do you think about the Cornerstone e-newsletter?
- National Gaming Day is Nov. 14
- Call for Ideas for the 2011 Collaborative Summer Library Program: Children, Teens, Adults
- ALSC revises competencies for serving children
- What's the next book in the series?
Featured eResource of the Month
WorldCat Expands!
- Loleta D. Fyan Grant for development of public libraries
- World Book Information Literacy Goal Award
- H.W. Wilson Library Staff Development Grant
- "We the People" Bookshelf Project
In Focus: Patsy Kringel
Meet Patsy Kringel, one of the Reference Associates at the South Dakota State Library.
- escWorks: More tips for using the new registration system
- The Filtering Frontier
- Looking for another way to advertise?
- Connects to Collections Survey is due Nov. 1
- Take another look at school library standards
- Voluntary free reading is key component in reading success
- Looking for motivation for your reluctant teen readers?
- Tools to use for Web site evaluation
- Where do I find movie review and purchasing resources?
- More resources in the news
- What is Library Development reading?
- To WriMo or not to WriMo: November is National Novel Writing Month
next: Library Headlines
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The Cornerstone monthly e-newsletter is created by the South Dakota State Library. For more information on how to be a part of this newsletter, please contact us via e-mail with your questions and ideas.


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Gillian Hatch analyses what goes on when mathematical games are used as a pedagogic device.
In this article for teachers, Liz Woodham describes the criteria she uses to choose mathematical games for the classroom and shares some examples from NRICH.
Not all of us a bursting with creative game ideas, but there are several ways to go about creating a game that will assist even the busiest and most reluctant game designer.
This article, the second in the series, looks at some different types of games and the sort of mathematical thinking they can develop.
This article supplies teachers with information that may be useful in better understanding the nature of games and their role in teaching and learning mathematics.
Basic strategy games are particularly suitable as starting points for investigations. Players instinctively try to discover a winning strategy, and usually the best way to do this is to analyse. . . .
An old game but lots of arithmetic!
A game to be played against the computer, or in groups. Pick a 7-digit number. A random digit is generated. What must you subract to remove the digit from your number? the first to zero wins.
A collection of games on the NIM theme
Some Games That May Be Nice or Nasty for an adult and child. Use your knowledge of place value to beat your opponent.
Dicey Operations for an adult and child. Can you get close to 1000 than your partner?
Shut the Box game for an adult and child. Can you turn over the cards which match the numbers on the dice?
Who said that adding couldn't be fun?
Throw the dice and decide whether to double or halve the number. Will you be the first to reach the target?
An article for teachers and pupils that encourages you to look at the mathematical properties of similar games.
A game for 2 players. Can be played online. One player has 1 red counter, the other has 4 blue. The red counter needs to reach the other side, and the blue needs to trap the red.
A game for 2 players. Take turns to place a counter so that it occupies one of the lowest possible positions in the grid. The first player to complete a line of 4 wins.
Can you spot the similarities between this game and other games you know? The aim is to choose 3 numbers that total 15.
Can you make the birds from the egg tangram?
Here is a version of the game 'Happy Families' for you to make and play.
This article invites you to get familiar with a strategic game called "sprouts". The game is simple enough for younger children to understand, and has also provided experienced mathematicians with. . . .
There are nasty versions of this dice game but we'll start with the nice ones...
Play this game and see if you can figure out the computer's chosen number.
A shunting puzzle for 1 person. Swop the positions of the counters at the top and bottom of the board.
The game uses a 3x3 square board. 2 players take turns to play, either placing a red on an empty square, or changing a red to orange, or orange to green. The player who forms 3 of 1 colour in a line. . . .
Take it in turns to make a triangle on the pegboard. Can you block your opponent?
A game for two or more players that uses a knowledge of measuring tools. Spin the spinner and identify which jobs can be done with the measuring tool shown.
Match the halves.
A game to make and play based on the number line.
This is a challenging game of strategy for two players with many interesting variations.
A game for 2 or more players with a pack of cards. Practise your skills of addition, subtraction, multiplication and division to hit the target score.
This is a game for 2 players. Each player has 4 counters each, and wins by blocking their opponent's counters. A good follow-on from two stones.
Use your addition and subtraction skills, combined with some strategic thinking, to beat your partner at this game.
A train building game for 2 players.
The aim of the game is to slide the green square from the top right hand corner to the bottom left hand corner in the least number of moves.
A game for 2 people using a pack of cards Turn over 2 cards and try to make an odd number or a multiple of 3.
Take it in turns to place a domino on the grid. One to be placed horizontally and the other vertically. Can you make it impossible for your opponent to play?
Work out the fractions to match the cards with the same amount of money.
This game challenges you to locate hidden triangles in The White Box by firing rays and observing where the rays exit the Box.
Advent Calendar 2010 - a mathematical game for every day during the run-up to Christmas.
Board Block game for two. Can you stop your partner from being able to make a shape on the board?
Nim-7 game for an adult and child. Who will be the one to take the last counter?
Seeing Squares game for an adult and child. Can you come up with a way of always winning this game?
Four Go game for an adult and child. Will you be the first to have four numbers in a row on the number line?
Factors and Multiples game for an adult and child. How can you make sure you win this game?
Train game for an adult and child. Who will be the first to make the train?
Strike it Out game for an adult and child. Can you stop your partner from being able to go?
Incey Wincey Spider game for an adult and child. Will Incey get to the top of the drainpipe?
Who said that adding, subtracting, multiplying and dividing couldn't be fun?
Here is a chance to play a version of the classic Countdown Game.