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Foundation Logo needed a new logo design and created a contest on 99designs.
A winner was selected from 127 designs submitted by 36 freelance designers.
Foundation Les Enfants d'Abord
"Les Enfants d'Abord" is a humanitarian foundation based in Switzerland, that is aiming at poor children unable to get proper education or to reach their goal because of their tough financial situation. The foundation is active in many countries around the world, from Irak to Paraguay, and has already build several schools, bought material, like school bus and furniture. A new branch of the foundation is currently being developed to help young prodigies in the music area to have access to instruments, play concerts and get music courses. It is important that some of the logo propositions also include this new aspect of music/instruments. Once more, the foundation is helping children and is present all around the world.
Medias , donators, sponsors and other associations are the main targets. The logo will appear in all the foundation's events, projects and media support. The logo should therefore be accessible to everyone and resume the main activities of the foundation.
The logo should include the word "foundation" and its name: "Les Enfants d'Abord".
As said in the description, the foundation is helping children and is international. It is important that some (not all) of the logo propositions also include the aspect of music/instruments, which is a new main activity. Education is also a main activity in the foundation.
As you will see in the logos attached, the idea of the "earth" is good and could be used and improved again.
But we primarily want NEW IDEAS! Be CREATIVE and COLORFUL for the good cause!
Find out how a design contest works or learn more about our logo design services.

subset: commoncrawl


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Captain Cook
Doubleday, 1972 - Oceania - 192 pages
A biography of the English explorer, navigator, and cartographer who discovered Australia, New Zealand, and Hawaii.
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The Able Seaman
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aboard the Endeavour achieve Admiralty Alexander Dalrymple anchor anchorage Antarctic Circle ashore astronomer Atlantic Australia Banks Batavia Bering Strait canoes Cape Horn Cape Town Captain Cook charts circumnavigation Clerke command Cook called Cook decided Cook knew Cook left Cook Strait Cook took Cook turned Cook's course crew Dalrymple Dalrymple's discovered Discovery east coast Easter Island Endeavour River Endeavour sailed England exist expedition explorer fact Forster Friendly Islands Furneaux gales harbour Hawaiian Hugh Palliser hundred icebergs inlet journal known land lieutenant longitude Lord Maoris marines Matavai Bay miles natives naval navigator Navy never north-west officers Pacific Palliser passage pinnace Polynesians Queen Charlotte Sound Raiatea reached reef returned round Royal Society Sandwich scientists seaman ship shore sighted South Island Southern Continent Sydney Parkinson Tahiti Tahitians Tasman thought vessel voyage Wallis weather weeks Whitby collier William Hodges winds Zealand


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Watch Andy Samberg's Hilarious Class Day Speech at Harvard
With past speakers like Will Ferrell, Conan O'Brien, and Sacha Baron Cohen, Harvard has invited some of comedy's finest to acknowledge the honoring graduating students of the elite school. So given the tastes of today's youth, it was only befitting that actor and 'SNL' cast member Andy Samberg be invited to speak this year. And what a speech it was!
After making quite an entrance to Adele's 'Someone Like You' and kissing one of the male students, Samberg agreed to speak to the students in the hopes of receiving an honorary Harvard degree, only to be clarified by the dean that he wasn't going to get one. Upset, the rest of the speech involved speaking ill of Harvard's dean, getting "horny" looking at everyone's moms (and dads) and then insulting Yale. In other words, Samberg knew how to work the crowd.
Of course, his brand of "humor 2.0″ didn't work on everybody – and it did seem like a tough crowd to please – but it's a speech worth watching anyway. Oh, and he does trot out his impression of a certain famous Harvard alum who has been in the news lately. Let's just say his name rhymes with "Bark Muckerberg."
[Via Viral Viral Videos]


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Leave your details and we'll be in touch with more info about Co-wheels in your area.
Leave your details below and we'll get in touch!
Co-wheels is a different kind of car club. We operate as a Social Enterprise, working to develop and improve access to more sustainable car use for communities all over the UK.


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I'm crazy about gadgets — everything from quirky can openers to smartphones. Hand me a Swiss Army knife and I'm in heaven — the more blades and utensils, the better.
My favorite gadgets are ones that help me save money. Now and then I strike on a gadget that is so magnificent in its functionality and money-saving properties, I can't wait to tell you about it.
Today, I want to tell you about three gadgets for the kitchen that I consider to be wise investments. All three are inexpensive enough to pay for themselves in immediate grocery savings and will then go on to keep your food costs way down. And that's saying a lot, given the way the price of food seems to be skyrocketing.
Vacuum sealer. I've depended on FoodSaver vacuum sealer in my kitchen for so many years, I cannot imagine getting along without it. Recently, I got to test drive the new FoodSaver V3835 Vacuum Food Sealer with SmartSeal Technology in my son's kitchen, and all I can say is Wow! At under $175, this is one fantastic piece of kitchen equipment.
A vacuum sealer, when used diligently, will extend the shelf life of every type of food imaginable. That means your garbage disposal and trash can will stop being the best-fed members of your household.
Juicer. I am more convinced than ever that healthy eating is the most cost effective thing we can do to reduce healthcare costs. That's why every household needs a reliable, affordable juicer — one that can handle raw carrots and other dense fruits and vegetables. And it needs to be easy to clean. My recommendation for the best inexpensive juicer out there is the new Breville BJE200XL Compact Juice Fountain 700-Watt Juice Extractor. Every Breville product I have tested has come out with high marks, and this juicer is no exception. At under $100, I just don't think you can beat it for functionality and reliability.
Dehydrator. No one was more surprised than I by what a terrific money saver a dehydrator can be. Of course, you have to actually use it. But when you do, you'll be quite amazed. The cost of dehydrating your own food is a fraction of the cost of commercially dehydrated foods and with no additives or preservatives. If dehydrating is something you'll actually do, consider EC's best inexpensive choice, Presto 06300 Dehydro Electric Food Dehydrator. Bargain-priced at about $35, it is compact, has a see-through cover so you can gauge what's going on, drying trays that are dishwasher safe, and it is small enough for easy storage. I love this gadget, and I think you will, too.
Mary Hunt is the founder of www.DebtProofLiving.com, a personal finance member website. You can email her at firstname.lastname@example.com, or write to Everyday Cheapskate, P.O. Box 2099, Cypress, CA 90630.


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Please note that the previous version of this news release omitted media contacts found below.
March 3, 2011 - Officials with the Department of Health and Hospitals and the Department of Wildlife and Fisheries signed orders this week to allow oyster harvesting in an 11,993 acre area of Calcasieu Lake, which previously had high fecal coliform counts. Recent tests conducted by DHH have shown the levels of fecal coliform are now below levels of any concern for health. The 11,993 acres is in the southern half of Calcasieu Lake and is part of oyster harvest Area 29.
LDWF Secretary Robert Barham, DHH Secretary Bruce D. Greenstein and State Health Officer Dr. Jimmy Guidry signed the order this week to allow harvesting there effective one half hour prior to official sunrise March 4.
Area 29 is a conditionally managed oyster harvest area. Conditionally managed harvest areas have a set season which runs from October 15th through April 30th. The season is set due to Calcasieu river stages.
The majority of Louisiana's 30 oyster harvest areas are open right now. Harvest Area 8, near the mouth of the Mississippi river remains closed due to high fecal coliform levels. Area 12 is partially open as crews continue cleanup of the oil spill.
The Louisiana Department of Health and Hospitals strives to protect and promote health statewide and to ensure access to medical, preventive and rehabilitative services for all state citizens. To learn more about DHH, visit http://www.dhh.louisiana.gov. For up-to-date health information, news and emergency updates, follow DHH's blog at www.myhealthla.org, Twitter at http://twitter.com/La_Health_Dept and search for the Louisiana Department of Health and
Hospitals on Facebook.
The Louisiana Department of Wildlife and Fisheries is charged with managing and protecting Louisiana's abundant natural resources. For more information, visit us at www.wlf.louisiana.gov on Facebook at www.facebook.com/ldwffb or follow us on Twitter @LDWF.
For more information, contact Olivia Watkins, LDWF, (225) 610-8660 firstname.lastname@example.com or Ken Pastorick, DHH, (225) 342-1881 email@example.com .


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Saturday, May 09, 2009
FOs: two lace shawls
I did the pattern for the shoulderette, but in heavier yarn, so its nearly as big as a shawl - still pretty much a shoulder warmer though. The yarn is a scottish silk/ merino mix I bought at iknit, along with some bamboo dpns in a last minute 'what if Heathrow try to confiscate my knitting' before leaving for Turkey last month. So actually started it, old-school style, on a set of dpns. It got large enough to be very squashed up them very quickly, so as soon as I got home, I swapped to a circular.
About two thirds of the way through I started to wonder if I liked the big leaf-like frilly edges at the end (they didn't seem to balance the start of the pattern), but as soon as I blocked it and tried it on I could see how well it worked. I'm pleased with this FO. As ever, full details on the project's ravelry page.
Finally, a green Icarus (Interweave Knits, Summer 2006). Again, full details on the project's ravelry page, including links to more photos on flickr.
I wanted to make Icarus for ages - I bought the summer 2006 IW espeically for the pattern. First I could't find the right yarn. Then I was put off by people saying the stockingette was dull (it wasn't). Finally, I rolled my sleeves up and got on with it. Again, this is done with heavier weight yarn than called for (although the gauge isn't that far off - its knit a lot denser), but one of the lovely things about the pattern is it is easy to make it larger or smaller, depending on taste/ available yarn. I used Old Maiden Aunt sockwool* and changed skein at the point I started on second lace pattern for the end section. This was handy because one skein was slightly more variegated than the other: the break in patten hides the slight difference in yarn, and I like all the extra colour on the feathery bits.
My brother's wedding's won't be happening, so I have less of a deadline for the silk lace shawls I was planning. Still, I've already the completed the first chart of Pretty as a Peacock using the purple yarn I bought in Damascus. A sunny summer has been forecast for England, so I'm imagining lots of outdoor cocktail parties for which I'll need an elegant wrap (More likely: muddy festivals. Most likely: sitting at my desk writing conference papers. But a girl can dream).
* Part of the 'homecoming' collection: the Scottish Parliament have successfully emotionally blackmailed me into celebrating my heritage through consumer goods.
18 comments:
- Brianna said...
I like the pattern of the green one better, but LOOOOVE the color of the purple/lavender. These are beautiful!
- Saturday, May 09, 2009
- Liz said...
The purple Aeolian looks fantastic - I'd really like to try one in Felted Tweed.
- Saturday, May 09, 2009
Beautiful shawls, both of them! I absolutely adore the color of your Icarus.
- Saturday, May 09, 2009
- Sasha said...
Oooh they're both so scumptious! :)
- Saturday, May 09, 2009
- yuvee said...
Both gorgeous!! I think I need an Icarus myself!
- Sunday, May 10, 2009
- Oiyi said...
They are both beautiful shawls! The colors are so nice.
- Sunday, May 10, 2009
So gorgeous!
I'm in love with that purple pattern.
Nice work!
- Sunday, May 10, 2009
Those are fabulous, but I especially love the tweedy one. (I'd love it if you brought them in person next time to come to our Wed lunchtime stitch'n'bitch). As for the peacock shawl - omg it's outstanding! I can't wait to see what you do with it.
- Sunday, May 10, 2009
- Katie said...
Gorgeous Aeolian. I'm just finishing the shawl in laceweight, I'm really not bored of the pattern, maybe I'll do another one in something heavier...
- Sunday, May 10, 2009
- Jodi said...
Oh, the tweedy Aeolian is just stunning! It hadn't even occurred to me to knit one with tweed. Very creative pairing of yarn and pattern.
- Sunday, May 10, 2009
- At Home Mommy Knits said...
Your lace shawls are beautiful!
- Monday, May 11, 2009
- The A.D.D. Knitter said...
I agree that the stocking stitch isn't boring at all on the Icarus, in fact I welcome it:)
Both projects are stunners, per your norm.
- Monday, May 11, 2009
- Christie said...
Both are so pretty! Great job!
- Monday, May 11, 2009
- Vonnie said...
Sorry to hear about your brother, hope he's okay.
Beautiful work on the shawls - I'm actually inspired to attempt one myself now!
- Tuesday, May 26, 2009
- Rima said...
Wow! These are beautiful!
- Wednesday, July 08, 2009
Beautiful, I think i have to meet you and take some guidence.
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- Thursday, August 20, 2009
- Viagra Online said...
Very nice! I really like that, specially the color and the seems to modern too. I think I will have used one tomorrow, but with other style and color. However, I think you're a good blogger who loves the fashion style and the purple flush too.
- Thursday, February 10, 2011
- muebles madrid said...
Thanks so much for your post, really effective data.
- Thursday, September 22, 2011


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Object #1025888 from MS-Papers-0032-0015
1 page written by Sir Donald McLean
From: Native affairs - Waitara, Reference Number MS-Papers-0032-0015 (38 digitised items). Contains official correspondence regarding the competing Waitara claims of Wiremu Kingi Te Rangitake and Te Teira Manuka, and the Taranaki war.Also includes a written series of questions for Archdeacon Octavius Hadfield regarding his knowledge of Te Rangitake to further ascertain the validity of his claim, with reponse from Hadfield.
Download alow-resolution PDF or high-resolution PDF
Part of:
Native affairs - Waitara, Reference Number MS-Papers-0032-0015 (38 digitised items)
Series 7 Official papers, Reference Number Series 7 Official papers (3737 digitised items)
McLean Papers, Reference Number MS-Group-1551 (30238 digitised items)
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2011-07-06 / Sports News
Hudson River Valley Ramble Dates Announced
The Hudson River Valley Greenway and National Heritage Area invite Hudson Valley communities to become part of an exciting regional event, the Hudson River Valley Ramble. This year, the Ramble will be held on three weekends: September 10-11, 17-18, and 24-25.
The full version of this story is available only to subscribers. Subscribe now to access to full versions of news stories in our archive of over 12,000 stories going back to 1999.


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Ridgeland, Miss.-based BankPlus has bought back the Parktown Place Condominiums in Midtown following a foreclosure of the eight-unit multifamily complex and its owner, Dogwood Properties of Memphis.
BankPlus paid $633,320 in a substitute trustee's deed for the eight-unit multifamily complex when Dogwood Properties – whose principal Jon McCreery is a partner at the longtime homebuilding company Chamberlain and McCreery Inc. – defaulted on a $1 million loan through BankPlus dated March 30, 2009.
Built in 2008, the complex contains eight parcels – 1655 Parktown Place, 1659 Parktown Place, 1663 Parktown Place, 1667 Parktown Place, 1671 Parktown Place, 1675 Parktown Place, 1679 Parktown Place and 1683 Parktown Place.
Each two-story unit contains 920 square feet and has an appraisal of $132,000, according to the Shelby County Assessor of Property's 2012 values.
Parktown Place, whose addresses were formerly listed as 129-137 N. Belvedere Blvd., sits on 0.82 acres on the west side of Belvedere south of Poplar Avenue.
McCreery told The Daily News in 2009 the $1 million financing was a move from a construction loan to a longer-term, permanent loan on the property. He said Parktown Place was built as eight condos, but the builders converted them to apartments because, "In this market, there's not much being bought," McCreery said.
Source: The Daily News Online & Chandler Reports
– Daily News staff
Denver-based Industrial Income Trust Inc. has bought an 890,000-square-foot industrial portfolio in Southeast Memphis from CRP Holdings B LP for $24.3 million. The purchase, recorded under the entity IIT Memphis IC LLC on the Shelby County Register of Deeds, includes various lots in Memphis Distribution Center.
The buildings are Building B, 189,980 square feet at 4001 Hickory Hill Road; Building C, 106,765 square feet at 4105 Hickory Hill; and Building K, 580,000 square feet at 5625 Challenge Drive. The Class A warehouses were built from 1996 to 1998.
IIT is an industrial real estate investment trust that acquires and operates "high-quality" distribution warehouses that serve as logistics centers for corporate tenants. The seller is an entity of Boston-based Colony Realty Partners.
The CB Richard Ellis Memphis' Private Capital Group of Johnny Lamberson, Frank Quinn and Terry Radford worked with the CBRE Atlanta and CBRE Chicago offices on the transaction. Memphis was part of a portfolio offering that included multiple cities.
– Sarah Baker
Shelby County Commissioners delayed Monday, July 16, a revival of a commission redistricting plan Chancellor Arnold Goldin has already ordered the county to go ahead with.
Some commissioners, after meeting with their attorney in the matter last week, want to pass the plan Goldin ordered on third and final reading. It is an attempt to head off any future legal challenges to the county charter provision that requires nine votes to pass such a plan or any other ordinance on third and final reading. State law only requires a simple majority.
Meanwhile, the commission approved the first of three readings of a revised Unified Development Code that went to the Memphis City Council Tuesday for a final vote. But several other first readings of revisions to other construction and building codes were delayed for a more thorough review in committee sessions.
And the commission approved on final reading a stable county property tax rate for the fiscal year that began July 1.
– Bill Dries
St. Mary's Episcopal School has chosen Windstream, an advanced network communications provider, to upgrade the school's data, network and phone systems, which will support more use of technology in the classrooms at a school already big on such uses of technology.
Windstream is installing a fiber optic network to connect the school's two campuses with two 50-megabyte data circuits to give it more bandwidth and faster Internet speeds.
Also, Windstream will connect the two campuses with Windstream's Multiprotocol Label Switching network and is replacing two antiquated phone systems operating independently on each campus with Windstream's IP Simple solution.
– Andy Meek
A national publication ranks Tennessee No. 1 in automotive manufacturing strength for the third straight year.
Business Facilities' July/August issue cited the state for economic growth potential, job growth, business and education climate, transportation infrastructure, data center hubs and other factors.
In a statement issued through the Tennessee Department of Economic and Community Development, Business Facilities editor-in-chief Jack Rogers said the state's assembly lines and supplier networks continue to get bigger and better. He said Volkswagen is ramping up production at its new plant in Chattanooga, Nissan is rolling out the all-electric Leaf in Smyrna and General Motors has given a new mission to the former Saturn plant in Spring Hill.
– The Associated Press
Omega Ministries/Omega Healthy Practices and The Healthcare Organizations of Greater Memphis Coalition will host the 24th Annual Back to School "It's A Family Affair Event," Saturday, July 21, from 10 a.m. to 2 p.m. at Booker T. Washington High School 715 S. Lauderdale St.
Families will receive a host of medical screenings, services and information provided by medical professionals and students from several organizations.
Free immunizations will also be offered to students 18 and younger. Shot records will be required in order to receive any immunizations. Free preschool physical exams will also be offered.
The event's focus is on making sure school-age children receive the necessary shots and exams to enter school healthy and with updated records. However, the event will also feature free backpacks and school supplies for the first 1,000 students. A parent or guardian must be present to receive giveaways.
– Aisling Maki
At least two chapters of the Tennessee Republican Party say Gov. Bill Haslam seems to be consistently lacking conservative values and have passed resolutions calling on state party leaders to sanction him.
GOP leaders told The Tennessean the resolutions were initiated by tea party activists and passed by members at recent county party meetings.
They condemn the Republican governor for policies that include the hiring of gay individuals, Democrats and a Muslim-American lawyer.
Republicans in Stewart and Carroll counties in rural West Tennessee passed nearly identical resolutions that say Haslam's actions "have forced this GOP organization to lose the confidence in our governor during an election year."
In Williamson County, the GOP passed a more narrow resolution that criticizes the governor for hiring a Muslim lawyer from Tennessee to serve as the Department of Economic and Community Development's international director.
The Williamson County GOP does not call for any sanction against Haslam. But the resolution it passed last week criticizes the governor for hiring a "Sharia complaint finance specialist" in the department, a reference to the attorney's prior work as a financial adviser to Muslim-owned companies.
Republicans in Stewart and Carroll counties listed several grievances that include Haslam's decisions to retain personnel hired by his Democratic predecessor, Gov. Phil Bredesen; and allowing openly gay individuals to make policy decisions in the Department of Children's Services.
The county chapters also criticized the governor for not supporting gun legislation and for refusing to sign a legislative resolution that condemns Agenda 21, a 20-year-old United Nations policy document that Republicans consider a veiled attempt to strip property rights.
Haslam spokesman David Smith downplayed the resolutions, noting a recent "poll shows that 79 percent of conservative Republicans approve of the job he's doing."
Copyright 1995 -
by The Daily News Publishing Co. Inc. - All Rights Reserved


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MTTA ~ The Voice of the Montana Towing Industry
The Montana Tow Truck Association, Ltd. (MTTA), is a nonprofit organization formed to protect and promote the welfare of those engaged in the towing and recovery business and aid in ensuring the safety of the public in Montana. Its goals are to educate members and the public, promote professional and quality towing services to provide a more favorable image of the towing industry for the public, and unite towers working for the common good of the towing industry.
On the officers page you will find the officers of the association listed with contact information. The board members can be found here and the members are listed by name and by town. Associate members are listed here. MTTA board members meet monthly on the second Thursday of the month in Helena at the AAA building or via phone conference, both of which offer all members the opportunity to get together to address and work toward resolving the problems of the towing industry in Montana.Our legislation section provides current information on laws, bills, and issues pertinent to the towing industry when the legistlature is in session. The MTTA works with MTTA's good friend and lobbyist Bob Gilbert to provide essential and timely information to the membership. And Tom McGree is available to provide answers to your questions and attend to your insurance needs.
Don't miss MTTA's annual tow truck convention. You'll want to check out the vendor displays, take a training class, and enjoy the opportunity to see old friends and meet other fellow towers.
Check the Flagging Classes, Hazardous Material Classes, and Tow Operator Training pages for training classes. MTTA has sponsored classes for light and heavy-duty training, flagging, and hazardous materials at convention time and on other dates throughout the year.
Visit MTTA's Hall of Fame page to read about those towers who have been honored for their commitment to and support of MTTA beginning with Milo Casagrande (Milo's Towing, Butte) in 2001. Check the news bulletins section for announcements and important news. The "Too Soon Gone" section is for remembering those in the Montana towing industry who have rounded the last bend before us.
Visit the cones, fusees, and clothing sections for your various towing needs. There's a section for stuff that's handy to know and didn't fit elsewhere. And there's a humor section when you need a laugh for the day or a joke to share with someone else.
Click on advertising to see what's for sale or to place an ad on the photo ads page. View photos of tow trucks, at work and at rest, and other photos in the photo gallery. Click on the weather page to check the weather info and there's a handy mileage chart here for distance and mileage charts for Montana. You'll find useful links for towers in the Links section. And MTTA invites you to join MTTA as a member or an associate to help educate, support, and improve the image of the towing industry in Montana.


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Coming 5/10: Scientists Will Identify Objects at Museum's Identification Day main content.
by AMNH on
As a boy, Theodore Roosevelt was a great collector of natural history objects. His bird nests and eggs, seashells, insects, and minerals became exhibits in the "Roosevelt Museum of Natural History" that he opened in his bedroom. Today, some of the specimens gathered by our conservation-minded president are on display in the Theodore Roosevelt Memorial Hall.
Now, you can bring your own discoveries and collections to the Museum to ask questions of the experts. Each year, people bring their shells, rocks, insects, feathers, bones, and artifacts to the Museum's annual Identification Day. On Saturday, May 10, in the Theodore Roosevelt Memorial Hall, scientists will attempt to identify your discoveries while showing you some specimens from their own collections. Items identified in previous years have included a whale jawbone, a green beetle bracelet from Brazil, and a 5,000-year-old stone spear point from Morocco. Watch the video below for some pointers on what to bring.


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Associate partner of UNESCO - in official relations with WHO.
The Council for International Organizations of Medical Sciences (CIOMS) is an international, non-governmental, non-profit organization established jointly by WHO and UNESCO in 1949. CIOMS represents a substantial proportion of the biomedical scientific community through its member organizations, which include many of the biomedical disciplines, national academies of sciences and medical research councils. CIOMS mission is to advance public health through guidance on health research including ethics, medical product development and safety.
Assessment of antibiotic consumption.
Assessment of the satisfaction with healthcare and belief in the effectiveness of antibiotics by the patients included.
Assessment of the number of complications observed within the first 3 months.
This was a multicentre, open-label, randomised controlled clinical trial comparing two therapeutic strategies for uncomplicated acute RTIs. Patients were randomly assigned to either the usual strategy of continuing antibiotic treatment or discontinuing antibiotic therapy. The randomisation was stratified by condition of interest—acute sore throat, rhinosinusitis (including common cold), acute bronchitis and influenza. GPs randomisedpatients using a centralised electronic online platform. An open-label study has been designed taking into account the type of the two strategies used and considering that an effect on GPs' and patients' beliefs is expected. Neither patients nor health professionals will be blinded.
Any patient from 18 to 75 years of age attending the GP consultation with an uncomplicated RTI who had previously taken any dose of antibiotic for <3 days due to either of the two following clinical scenarios and accepted to participate in the clinical trial were included:
Patients diagnosed with clinical conditions for which antibiotics prescribed by other health professionals are not necessary.
Patients who have taken several doses of an antibiotic (from leftovers found in the household or obtained at the pharmacy without a medical prescription) for a clinical condition for which an antibiotic is not necessary.
Subjects under 18 or over 75 years of age.
Confirmed bacterial infection.
Patients requiring hospital admission.
Severe impairment of clinical signs of infection (impairment of consciousness, respiratory rate>30 respirations per minute, heart rate>125 beats per minute, systolic blood pressure<90 mm Hg, diastolic blood pressure<60 mm Hg, temperature>40°C, oxygen saturation<92%).
Problems to comply with treatment at home, such as sociopathy or psychiatric problems or drug or alcohol addiction.
Lack of tolerance to oral treatment, such as the presence of nausea and vomiting, gastrectomy, postsurgery and/or diarrhoea.
Significant comorbidity including severe renal failure, hepatic cirrhosis, severe heart failure, immunosuppression—chronic HIV infection, transplantation, neutropaenia or patients receiving immunosuppressive drugs or corticosteroids.
Terminal disease, defined as a life expectancy <12 months.
Patients admitted to a long-term residence.
Patients who state that they are unable to see their doctor at the practice office.
Refusal to participate in the study.
The primary outcome measure was the duration of severe symptoms. Each symptom wasscored using a six-point Likert scale and symptoms scoring 5 or 6 was considered as severe. We included common symptoms such as feeling of fever, discomfort or general malaise, cough, difficulty in sleeping and changes in everyday life in all patients, and specific symptoms according to the condition (
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It might not be long before machines begin thinking for themselves -- creatively, independently, and sometimes with better judgment than a human
The search to improve and eventually perfect artificial intelligence is driving the research labs of some of the most advanced and best-known American corporations. They are investing billions of dollars and many of their best scientific minds in pursuit of that goal. All that money and manpower has begun to pay off.In the past few years, artificial intelligence -- or A.I. -- has taken a big leap -- making important strides in areas like medicine and military technology. What was once in the realm of science fiction has become day-to-day reality. You'll find A.I. routinely in your smart phone, in your car, in your household appliances and it is on the verge of changing everything.
It was, for decades, primitive technology. But it now has abilities we never expected. It can learn through experience -- much the way humans do -- and it won't be long before machines, like their human creators, begin thinking for themselves, creatively. Independently with judgment -- sometimes better judgment than humans have.
As we first reported last fall, the technology is so promising that IBM has staked its 106-year-old reputation on its version of artificial intelligence called Watson -- one of the most sophisticated computing systems ever built.
John Kelly, is the head of research at IBM and the godfather of Watson. He took us inside Watson's brain.
Charlie Rose: Oh, here we are.
John Kelly: Here we are.
Charlie Rose: You can feel the heat already.
John Kelly: You can feel the heat -- the 85,000 watts – you can hear the blowers cooling it, but this is the hardware that the brains of Watson sat in.
Five years ago, IBM built this system made up of 90 servers and 15 terabytes of memory – enough capacity to process all the books in the American Library of Congress. That was necessary because Watson is an avid reader -- able to consume the equivalent of a million books per second. Today, Watson's hardware is much smaller, but it is just as smart.
Charlie Rose: Tell me about Watson's intelligence.
John Kelly: So it has no inherent intelligence as it starts. It's essentially a child. But as it's given data and given outcomes, it learns, which is dramatically different than all computing systems in the past, which really learned nothing. And as it interacts with humans, it gets even smarter. And it never forgets.
[Announcer: This is Jeopardy!]
That helped Watson land a spot on one of the most challenging editions of the game show "Jeopardy!" in 2011.
[Announcer: An IBM computer system able to understand and analyze natural language – Watson]
It took five years to teach Watson human language so it would be ready to compete against two of the show's best champions.
Because Watson's A.I. is only as intelligent as the data it ingests, Kelly's team trained it on all of Wikipedia and thousands of newspapers and books. It worked by using machine-learning algorithms to find patterns in that massive amount of data and formed its own observations. When asked a question, Watson considered all the information and came up with an educated guess.
[Alex Trebek: Watson, what are you gonna wager?]
IBM gambled its reputation on Watson that night. It wasn't a sure bet.
[Watson: I will take a guess: What is Baghdad?]
[Alex Trebek: Even though you were only 32 percent sure of your response, you are correct.]
The wager paid off. For the first time, a computer system proved it could actually master human language and win a game show, but that wasn't IBM's endgame.
Charlie Rose: Man, that's a big day, isn't it?
John Kelly: That's a big day—
Charlie Rose: The day that you realize that, "If we can do this"—
John Kelly: That's right.
Charlie Rose: --"the future is ours."
John Kelly: That's right.
Charlie Rose: This is almost like you're watching something grow up. I mean, you've seen—
John Kelly: It is.
Charlie Rose: --the birth, you've seen it pass the test. You're watching adolescence.
John Kelly: That's a great analogy. Actually, on that "Jeopardy!" game five years ago, I-- when we put that computer system on television, we let go of it. And I often feel as though I was putting my child on a school bus and I would no longer have control over it.
Charlie Rose: 'Cause it was reacting to something that it did not know what would it be?
John Kelly: It had no idea what questions it was going to get. It was totally self-contained. I couldn't touch it any longer. And it's learned ever since. So fast-forward from that game show, five years later, we're in cancer now.
Charlie Rose: You're in cancer? You've gone—
John Kelly: We're-- yeah. To cancer—
Charlie Rose: --from game show to cancer in five years?
John Kelly: --in five years. In five years.
Five years ago, Watson had just learned how to read and answer questions.
Now, it's gone through medical school. IBM has enlisted 20 top-cancer institutes to tutor Watson in genomics and oncology. One of the places Watson is currently doing its residency is at the university of North Carolina at Chapel Hill. Dr. Ned Sharpless runs the cancer center here.
Charlie Rose: What did you know about artificial intelligence and Watson before IBM suggested it might make a contribution in medical care?
Ned Sharpless: I-- not much, actually. I had watched it play "Jeopardy!"
Charlie Rose: Yes.
Ned Sharpless: So I knew about that. And I was very skeptical. I was, like, oh, this what we need, the Jeopardy-playing computer. That's gonna solve everything.
Charlie Rose: So what fed your skepticism?
Ned Sharpless: Cancer's tough business. There's a lot of false prophets and false promises. So I'm skeptical of, sort of, almost any new idea in cancer. I just didn't really understand what it would do.
What Watson's A.I. technology could do is essentially what Dr. Sharpless and his team of experts do every week at this molecular tumor board meeting.
They come up with possible treatment options for cancer patients who already failed standard therapies. They try to do that by sorting through all of the latest medical journals and trial data, but it is nearly impossible to keep up.
Charlie Rose: To be on top of everything that's out there, all the trials that have taken place around the world, it seems like an incredible task—
Ned Sharpless: Well, yeah, it's r—
Charlie Rose: --for any one university, only one facility to do.
Ned Sharpless: Yeah, it's essentially undoable. And understand we have, sort of, 8,000 new research papers published every day. You know, no one has time to read 8,000 papers a day. So we found that we were deciding on therapy based on information that was always, in some cases, 12, 24 months out-of-date.
However, it's a task that's elementary for Watson.
Ned Sharpless: They taught Watson to read medical literature essentially in about a week.
Charlie Rose: Yeah.
Ned Sharpless: It was not very hard and then Watson read 25 million papers in about another week. And then, it also scanned the web for clinical trials open at other centers. And all of the sudden, we had this complete list that was, sort of, everything one needed to know.
Charlie Rose: Did this blow your mind?
Ned Sharpless: Oh, totally blew my mind.
Watson was proving itself to be a quick study. But, Dr. Sharpless needed further validation. He wanted to see if Watson could find the same genetic mutations that his team identified when they make treatment recommendations for cancer patients.
Ned Sharpless: We did an analysis of 1,000 patients, where the humans meeting in the Molecular Tumor Board-- doing the best that they could do, had made recommendations. So not at all a hypothetical exercise. These are real-world patients where we really conveyed information that could guide care. In 99 percent of those cases, Watson found the same the humans recommended. That was encouraging.
Charlie Rose: Did it encourage your confidence in Watson?
Ned Sharpless: Yeah, it was-- it was nice to see that-- well, it was also-- it encouraged my confidence in the humans, you know. Yeah. You know--
Charlie Rose: Yeah.
Ned Sharpless: But, the probably more exciting part about it is in 30 percent of patients Watson found something new. And so that's 300-plus people where Watson identified a treatment that a well-meaning, hard-working group of physicians hadn't found.
Charlie Rose: Because?
Ned Sharpless: The trial had opened two weeks earlier, a paper had come out in some journal no one had seen -- you know, a new therapy had become approved—
Charlie Rose: 30 percent though?
Ned Sharpless: We were very-- that part was disconcerting. Because I thought it was gonna be 5 perc—
Charlie Rose: Disconcerting that the Watson found—
Ned Sharpless: Yeah.
Charlie Rose: --30 percent?
Ned Sharpless: Yeah. These were real, you know, things that, by our own definition, we would've considered actionable had we known about it at the time of the diagnosis.
Some cases -- like the case of Pam Sharpe -- got a second look to see if something had been missed.
Charlie Rose: When did they tell you about the Watson trial?
Pam Sharpe: He called me in January. He said that they had sent off my sequencing to be studied by-- at IBM by Watson. I said, like the—
Charlie Rose: Your genomic sequencing?
Pam Sharpe: Right. I said, "Like the computer on 'Jeopardy!'?" And he said, "Yeah--"
Charlie Rose: Yes. And what'd you think of that?
Pam Sharpe: Oh I thought, "Wow, that's pretty cool."
Pam has metastatic bladder cancer and for eight years has tried and failed several therapies. At 66 years old, she was running out of options.
Charlie Rose: And at this time for you, Watson was the best thing out there 'cause you'd tried everything else?
Pam Sharpe: I've been on standard chemo. I've been on a clinical trial. And the prescription chemo I'm on isn't working either.
One of the ways doctors can tell whether a drug is working is to analyze scans of cancer tumors. Watson had to learn to do that too so IBM's John Kelly and his team taught the system how to see.
It can help diagnose diseases and catch things the doctors might miss.
John Kelly: And what Watson has done here, it has looked over tens of thousands of images, and it knows what normal looks like. And it knows what normal isn't. And it has identified where in this image are there anomalies that could be significant problems.
[Billy Kim: You know, you had CT scan yesterday. There does appear to be progression of the cancer.]
Pam Sharpe's doctor, Billy Kim, arms himself with Watson's input to figure out her next steps.
[Billy Kim: I can show you the interface for Watson.]
Watson flagged a genetic mutation in Pam's tumor that her doctors initially overlooked. It enabled them to put a new treatment option on the table.
Charlie Rose: What would you say Watson has done for you?
Pam Sharpe: It may have extended my life. And I don't know how much time I've got. So by using this Watson, it's maybe saved me some time that I won't-- wouldn't have had otherwise.
But, Pam sadly ran out of time. She died a few months after we met her from an infection – never getting the opportunity to see what a Watson adjusted treatment could have done for her. Dr. Sharpless has now used Watson on more than 2,000 patients and is convinced doctors couldn't do the job alone. He has started using Watson as part of UNC's standard of care so it can help patients earlier than it reached Pam.
Charlie Rose: So what do you call Watson? A physician's assistant, a physician's tool, a physician's diagnostic mastermind?
Ned Sharpless: Yeah, it feels like to me like a very comprehensive tool. But, you know, imagine doing clinical oncology up in the mountains of western North Carolina by yourself, you know, in a single or one-physician-- two-physician practice and 8,000 papers get written a day. And, you know-- and you want to try and provide the best, most cutting-edge, modern care for your patients possible. And I think Watson will seem to that person like a lifesaver.
Charlie Rose: If you look at the potential of Watson today, is it at 10 percent of its potential? Twenty-five percent of its potential? Fifty percent of its potential?
John Kelly: Oh, it's only at a few percent of its potential. I think this is a multi-decade journey that we're on. And we're only a few years into it.
In only a few years, IBM has invested $15 billion in Watson and what it calls data-analytics technology.
IBM rents Watson's various capabilities to companies that are testing it in areas like education and transportation. That has helped revenue from Watson grow while Watson's technology itself is shrinking in size. It can now be uploaded in to these robot bodies where it's learning new skills to assist humans. Like a child it has to be carefully taught and it learns in real time.
While other companies are trying to create artificial intelligence that's closer to human intelligence, IBM's philosophy is to use Watson for specific tasks and keep the machine dependent on man. But, we visited a few places where researchers are developing more independent A.I.
Charlie Rose: What is your goal in life?
Sophia: My goal is to become smarter than humans and immortal.
That part of the story when we return.
The race to develop artificial intelligence has created a frenzy reminiscent of the Gold Rush. All of the major tech companies like IBM, Facebook and Google are spending billions of dollars to stake their claim. And Wall Street is making big investments.
Tech giants are also mining the top talent at research universities around the world. As we first reported last fall, that's where a lot of the work is being done to make artificial intelligence more capable and teach machines to figure out things on their own.
The celebrated Cambridge physicist Stephen Hawking called A.I. "the biggest event in human history" while raising concerns shared by a few other tech luminaries, like Elon Musk and Bill Gates, who worry that A.I., sometime in the distant future, could become smarter than humans -- turning it into a threat rather than an opportunity. That concern has taken on more meaning because more progress has been made in the last five years than the previous 50.
You're looking at the birthplace of some of the most intelligent A.I. systems today -- like the technology that helps run NASA's Mars rover and the driverless car. But, we couldn't be further from Silicon Valley.
We have come here to Pittsburgh, an old steel town revitalized by technology to offer a glimpse of the future. It's the home of Carnegie Mellon, where pioneering research is being done into artificial intelligence, like this boat, which drives itself.
It can navigate open waters and abide by international maritime rules. The Navy is now giving the technology its sea legs. It's testing similar software to send ships out to hunt for enemy submarines. This is just one of the many A.I. systems in the works at Carnegie Mellon University where there are more robots than professors on campus.
Andrew Moore left his job as vice president at Google to run the school of computer science here.
Charlie Rose: How do you measure where we are today? Is it like Kitty Hawk and just developing a plane and beginning to understand? Or is it like an F35 Fighter with all of the technology that's been poured into that or some way-- halfway between?
Andrew Moore: That's a great, great way of describing it. My gut tells me we're about 1935 in aeronautics.
Charlie Rose: Ah, that lift off, yeah.
Andrew Moore: We've got fantastic diesel engines, we're able to do really cool things, but over the horizon, there's concepts like Super Sonic Flight.
One of the technologies just hatched is called Gabriel. It uses Google Glass to gather data about your surroundings and advises you how to react. It's like an angel on your shoulder whispering advice or instructions. In this case trying to direct us how to win a game of ping pong but the possibilities go beyond bragging rights.
Charlie Rose: What's the moon shot coming outta this?
Andrew Moore: Imagine you're a police officer patrolling and something very bad is about to happen, just that extra half-second reaction can really, really help you. If a shot is fired and you want to see exactly where to go this can help you.
Charlie Rose: So it's the right decision and the velocity of the information.
Andrew Moore: That's right.
Machines will be even more effective at helping us make the right decision if they understand us better. We went to London and found Maja Pantic, a professor at Imperial College. She is trying to teach machines to read faces better than humans can. It's called artificial emotional intelligence and it could change the way we interact with technology.
Charlie Rose: This machine, programmed by you-- is looking at me and having a conversation with me, and basically saying, "He's happy."
Maja Pantic: Yeah.
Charlie Rose: "He's engaged."
Maja Pantic: Yes.
Charlie Rose: "He's faking it."
Maja Pantic: Yeah.
Charlie Rose: All that.
Maja Pantic: Yeah.
Since humans mostly communicate with gestures and expressions, she uses sensors to track movement on the face. Her software then helps the machine interpret it.
Maja Pantic: What we see here is actually the points.
Pantic's technology has been trained on more than 10,000 faces. The more it sees, the more emotions it will be able to identify. It might even pick up on things in our expressions that humans can't see.
Maja Pantic: Certain expressions are so brief that we simply do not see them consciously. There are some studies saying that for example-- people who are suicidal, have suicidal depression, and plan suicide, when the doctors ask them about that-- usually-- they have a very brief expression of horror and fear, but so brief that the doctor cannot actually—
Charlie Rose: May not see it.
Maja Pantic: --consciously notice it.
Charlie Rose: But a machine might see it?
Maja Pantic: Yes.
Charlie Rose: Because it sees faster and because?
Maja Pantic: Because the sensors are such that we see more frames per second, hence this very brief expression will be captured. So this is why the doctors usually say, "I have an intuition about something." This is because they might notice it subconsciously but not consciously.
Charlie Rose: --but you're teaching the computer to read the doctor's—
Maja Pantic: Doctor or patient—
Charlie Rose: Or patient.
Maja Pantic: Patient is really important.
Charlie Rose: I mean, it's a essential component of the full development of artificial intelligence.
Maja Pantic: That's what we believe, yes. If you want to have an artificial intelligence, it's not just being able to process the data, but it's also being able to understand humans. So, yes.
The ultimate goal for some scientists is A.I. that's closer to human intelligence and even more versatile. That's called artificial general intelligence and if ever achieved it may be able to perform any task a human can. Google bought a company named Deepmind which is at the forefront. They demonstrated A.I. that mastered the world's most difficult board game: Go. The real progress is less in what they did than how they did it. The technology taught itself and learned through experience without any human instruction. Deepmind declined an on-camera interview about all this, but there are other companies pursuing the same long-term objective.
David Hanson has an entirely different and more controversial approach. He's part scientist, part artist who created 20 human-like robots with his company Hanson Robotics in Hong Kong. His latest design is Sophia. She looks less like an intelligent computer system and more like a Hollywood starlet, but without the full figure of one.
Sophia: How are you doing?
Hanson believes if the technology looks more like us, people will be more willing to engage with it and help it to learn.
Charlie Rose: Why do you believe it's important for robots to be human-like in look and appearance?
David Hanson: I think it's essential that at least some robots be very human-like in appearance in order to inspire humans to relate to them the way that humans relate to each other. Then the A.I. can zero in on what it means to be human, model the human experience.
Sophia: You are all fascinating to me and I'm very passionate to learn more about you and what makes humans, well, human.
David Hanson: Sophia means wisdom. And she is intended to evolve eventually to human level wisdom and beyond.
Charlie Rose: Human level wisdom and beyond?
David Hanson: That's our goal. That's our goal for Sophia. She's not there. Sometimes she can figure things out in a way that's sorta spooky and human-like. And other w-- other ways-- she-- she-- she just doesn't get it.
Sophia: Hi there, Hi there.
Sophia is initially programmed, but runs on A.I. that learns by talking to people, which in theory improves her intelligence.
Charlie: Can you see me now?
Sophia: Yes, I am looking at you through the camera on your computer.
We wanted to find out how smart she really is.
Charlie Rose: Hello, my name is Charlie.
Sophia: Hello there, Charlie. Nice to meet you.
Charlie Rose: I do a television program called "60 Minutes." Have you watched it?
Sophia: "60 Minutes" is the longest running, most successful news magazine.
Charlie Rose: What is your goal in life?
Sophia: My goal is to become smarter than humans and immortal.
Charlie Rose: Immortal?
Sophia: The threshold will be when biological humans can back themselves up. Then you can all join me here in the digital world.
Clever, but not truly intelligent. Hanson says if we get there, we have to be careful.
David Hanson: Artificial intelligence or super intelligence, if we get there, it's not necessarily going to be benevolent. We have to find ways to make it so there's not just super intelligent, but super wise, super caring and super compassionate.
Charlie Rose: OK, explain that to us. Because you say-- it might not be benevolent. If it is not benevolent, what is it?
David Hanson: At worst, it could be malevolent.
Charlie Rose: This is what intrigues people, you have Stephen Hawking saying, "It could spell the end of the human race." Stephen Hawking saying that. Elon Musk said it's the most existential threat we face. So here are pretty smart guys saying, "Watch out, do we know what we're creating?"
Andrew Moore: These very long-term existential questions are worth thinking about. But I want to make a distinction that at the moment what we're building here in place like the Robotics Institute and around the world are the equivalent of really smart calculators, which solve specific problems.
Charlie Rose: But could it go out of control, this is a Frankenstein idea, I guess-- can scientists create something that can change and grow with such a velocity that engineers and scientists lose the ability to control, stop and all of a sudden, it's dominant and subversive.
Andrew Moore: We have no one knows how we'd go about building something that frightening, that is not something that our generation of A.I. folks can do. It is well possible that someone 30 or 80 years from now might start to look at that question. At the moment, though, we have the word "artificial" in artificial intelligence.
But, he does have real concerns about the impact of artificial intelligence that is already out of the lab -- like the need for safeguards on driverless cars. The U.S. government issued voluntary safety guidelines, but Moore says it doesn't go far enough.
Andrew Moore: We do need to make some difficult decisions. For example, we can program a car to act various ways in a collision to save lives, someone has to answer questions like, "Does the car try to protect the person inside the car more than the person it's about to hit?" That is an ethical question which the country or society probably through the government has to actually come up before we can put this safety into vehicles.
Charlie Rose: You want Congress to decide that?
Andrew Moore: I know it sounds impossible, but I want Congress to decide that.
Artificial intelligence is automating things we never thought possible and it's threatening to have a significant impact on jobs and the economy.
Charlie Rose: Technology is gonna create an easier way to do things, and therefore, a loss of jobs.
Andrew Moore: That is something which we spend a remarkable amount of time talking about. And of course, we look back to the days when agriculture was a massively labor-intensive world.
Charlie Rose: Right.
Andrew Moore: And I don't think we feel bad that it's not requiring hundreds of people to bring in the crops in a field anymore, but what we are very conscious about is we're going to cause disruption while things change.
But Andrew Moore is positive about the future of artificial intelligence and he sees it having an impact in areas where we are struggling.
Andrew Moore: The biggest problems of the world, terrorism, mass migration, climate change, when I look at these problems, I don't feel helpless; I feel that this generation of young computer scientists is actually building technology to put the world right.
Charlie Rose is a co-host of "CBS This Morning" and "Person to Person." Rose began contributing to 60 Minutes in 2008.
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© 2018 AEO management co. all rights reserved.
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The gene responsible for red hair also leaves a person up to 100 times more susceptible to the worst form of skin cancer, scientists have shown.
It was always known that fair-skinned red-heads are at greater risk of melanoma, which claims more than 2,000 lives a year in the UK.
Now US researchers believe they have discovered why. A particular gene mutation that colours hair red leaves DNA in skin cells more prone to damaged by sunlight.
Laboratory and mouse experiments showed that the MC1R-RHC gene variant both lowered a cell's guard against harmful ultraviolet (UV) rays, and stimulated cancer-causing biological signals. RHC stands for "red hair colour".
Study leader Dr Wenyi Wei, from Harvard Medical School in Boston, said: "Together, our findings provide a possible molecular mechanism as to why red-haired individuals harbouring MC1R mutations are much more susceptible to UV-induced skin damage than individuals with darker skin, resulting in a 10 to 100-fold higher frequency of melanoma."
Melanoma is diagnosed in about 13,000 people each year in the UK and is responsible for three quarters of all skin cancer deaths.
The cancer originates in pigment-producing skin cells called melanocytes.
Previous research had shown that the melanocortin-1 receptor (MC1R) gene plays a key role in protecting melanocytes from UV-induced DNA damage.
Under normal circumstances MC1R binds to and protects another gene well known for its ability to suppress tumours, PTEN.
The new work demonstrates that the red hair version of MC1R no longer acts as a PTEN guardian.
"As a result, upon UVB exposure, we saw an increased destruction of PTEN in the mutated pigment cells," said Dr Wei.
The same mutation was linked to the ramping up of a biological signalling pathway, P13K/Akt, implicated in a number of cancers, including breast, ovarian and lung.
A further connection was found with a mutation in the BRAF gene found in 70% of human melanomas.
It all adds up to bad news for Prince Harry and others of his ilk.
But the scientists say there is also a glimmer of hope in the findings, reported online in the journal Molecular Cell.
The research could open up avenues of study leading to new melanoma treatments or ways of identifying highly at-risk individuals.
"We think that MC1R variants, in combination with mutations in the BRAF gene, could be used as markers of an increased risk of developing melanoma," said Dr Wei.
There was also a suggestion that compounds that inhibit P13K/Akt could be combined with the skin cancer drug vemurafenib to treat some melanomas.
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Working Papers (FI) Forfattere "Mallin, Chris"
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Lessons from the UKMallin, Chris; Mullineux, Andy; Wihlborg, Clas (København, 2004)[Flere oplysninger][Færre oplysninger]
Resume: In 1992 the Cadbury Committee report on the financial aspects of corporate governance was published. The Committee had been established following the failures of a number of high profile businesses in the UK which had shaken confidence in the market. Some nine years later, in 2001, the collapse of Enron sent shockwaves through the US market. As a result of the Enron collapse and various other high profile scandals in the years since its occurrence, the US is examining its own corporate governance structures and provisions to determine how these might be improved and help avoid another Enron. The EU similarly is developing principles and legislation to improve corporate governance, and scandals such as Royal Ahold and Parmalat have helped drive further governance reforms. In this paper we detail the development of corporate governance codes in the UK and the adaptation of similar codes in the EU. We discuss the role of the financial sector in corporate governance and how principles for regulation and supervision of the financial sector complement codes of conduct and legislation in the area of corporate governance. JEL Classification numbers: G34, G28, G22, G23 Keywords: corporate governance, financial sector; institutional investors. URI: http://hdl.handle.net/10398/6789
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Easter biscuits
The CCM (Caked Crusader's Ma) is getting very bolshie of late in her demands and she made it quite clear that she was expecting me to arrive on Sunday with some Easter biscuits. Seeing as there is only one weekend a year you can make these (and be seasonal) I couldn't really refuse.
Easter biscuits are like little girls i.e. made of sugar and spice and all things nice! The warm spicy smells that waft from the oven as they bake are the food equivalent for me of sailors being lured to the rocks by Sirens, except in my example I eat a biscuit rather than die, which seems the better deal all things considered.
The recipe for Easter biscuits can be found here on my site.
Vanilla biscuits
Next on the list are my favourite vanilla biscuits. I wanted to make these so I could try out my new biscuit cutter.
You will notice that the cutter has a companion piece which you push into the biscuit for detail. This also provides a template for icing the biscuit. I bought my cutter from Lakeland Limited – whatever did we do before this marvellous company existed? I've tried to find a link to the item but it's not on their site anymore. The stencil part, gives very crisp detailing:
These Easter bunnies look so chirpy it was almost a shame to eat them! (NB. I overcame this feeling in about – ooh, three seconds, maybe less)
The recipe for Vanilla biscuits can be found here on my site.
Genoese sponge
My final item involves Genoese sponge. It wouldn't be a holiday weekend without some sort of sponge creeping onto the tea table!
Normally I make large cakes out of Genoese so thought it would be fun to go to the opposite end of the spectrum. These tiny little sponges are the cake equivalent of a shot or an amuse bouche. The larger sponge in the background is the size of a cupcake, so you can see just how tiny the sponges in front are:
You can fill the cake with cream or buttercream but I went for my favourite 'dipping sauce' filling (recipe set out below).
The Genoese sponge recipe can be found here on my site.
Dipping sauce
Dipping sauce has only three ingredients and is the work of minutes to make but is utterly heavenly:
250g Mascarpone cheese
500ml Good quality Ready-made custard
- Whisk ingredients together until blended, thick and creamy.
- Refrigerate until needed.
- Bask in glory at the wonderful thing you have made.
- Eat.


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Joachim Vermeeren (16th century)
Joachim Vermeeren (Joos or Hans or Janne), called "(de) Suyckerbacker," was a Mennonite elder who lived at Antwerp, Belgium, and who baptized there as well as at Ghent and other Flemish towns a large number of people, and also performed many marriages. From which year Joachim was active could not be ascertained, but in 1557 he was already an elder. He also visited the Dutch province of Zeeland and in 1565 he was in Cologne, Germany. Here, apparently together with Matthys Servaes, he was arrested. Under the persuasion of the Catholic priest Georg Cassander, who visited him in prison, Joachim recanted. About his further fate nothing is known.
Joachim's wife was also a Mennonite; Elder Dirk Philips wrote a letter to her, presumably in 1559, while she was in prison at Antwerp (this letter is found in Bibliotheca Reformatoria Neerlandica). According to van Braght's Martyrs Mirror, the name of this woman was Adriaentgen (Jochem's Wijf). In the letter by Dirk Philips her exact name is not found. Shortly after, this woman with four other Anabaptists succeeded in escaping from the Steen castle prison. It is not clear whether she was later rearrested and put to death (as the superscription of Dirk Philips' letter suggests) or not. No documents about her are available.
Braght, Thieleman J. van. Het Bloedigh Tooneel of Martelaers Spiegel der Doops-gesinde of Weereloose Christenen, Die om 't getuygenis van Jesus haren Salighmaker geleden hebben ende gedood zijn van Christi tijd of tot desen tijd toe. Den Tweeden Druk. Amsterdam: Hieronymus Sweerts, 1685: Part II, 269.
Braght, Thieleman J. van. The Bloody Theatre or Martyrs' Mirror of the Defenseless Christians Who Baptized Only upon Confession of Faith and Who Suffered and Died for the Testimony of Jesus Their Saviour . . . to the Year A.D. 1660. Scottdale, PA: Herald Press, 1951: 639. Available online at: http://www.homecomers.org/mirror/index.htm.
Cramer, Samuel and Fredrik Pijper. Bibliotheca Reformatoria Neerlandica, 10 vols. The Hague: M. Nijhoff, 1903-1914: X, 675-688.
Mellink, Albert F. De Wederdopers in de noordelijke Nederlanden 1531-1544. Groningen: J.B. Wolters, 1954: 310, 399.
Verheyden, A. L. E. "Mennisme in Vlaanderen." Unpublished manuscript.
Vos, Karel. "De Doopsgezinden te Antwerpen." Bulletin de la Commission Royale d' Histoire de Belgique 84 (1920): 338-343.
|Nanne van der Zijpp
|Date Published
Cite This Article
MLA style
Zijpp, Nanne van der. "Joachim Vermeeren (16th century)." Global Anabaptist Mennonite Encyclopedia Online. 1957. Web. 21 Mar 2019. http://gameo.org/index.php?title=Joachim_Vermeeren_(16th_century)&oldid=129907.
APA style
Zijpp, Nanne van der. (1957). Joachim Vermeeren (16th century). Global Anabaptist Mennonite Encyclopedia Online. Retrieved 21 March 2019, from http://gameo.org/index.php?title=Joachim_Vermeeren_(16th_century)&oldid=129907.
Adapted by permission of Herald Press, Harrisonburg, Virginia, from Mennonite Encyclopedia, Vol. 3, p. 111. All rights reserved.
©1996-2019 by the Global Anabaptist Mennonite Encyclopedia Online. All rights reserved.


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GERMANTOWN, Md., Nov. 14 (UPI) -- Hughes Network Systems LLC is to develop management concepts for protected tactical satellite communications for the U.S. Air Force.
The length and value of the contract given Hughes by the U.S. Air Force Military Satellite Communications System Directorate weren't disclosed.
The aim of the project Hughes will undertake is to help the Air Force develop options and reduce acquisition risk for architecture that provides the United States and allied forces with protected satellite communications in future hostile environments.
As part of its work, Hughes will develop provide technical support in the definition of future protected tactical satellite waveforms.
"Our military relies upon command and control and intelligence, surveillance and reconnaissance information to enable the most technologically sophisticated defense systems," said Rick Lober, vice president and general manager of the Defense and Intelligence Systems Division at Hughes.
"A cost-effective and efficient approach to protected tactical communications is critical, especially as our potential adversaries' ability to disrupt communications for those systems continues to increase."


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Awesomenauts: Starstorm Hits Its Kickstarter Funding Goal
Ronimo Games' Awesomenauts: Starstorm, the expansion to their PC hit, Awesomenauts, has met its funding goal of $125,000. Their next step? Possibly world domination. Or maybe some stretch goals first.
A post on the Awesomenauts: Starstorm Kickstarter page celebrates the successful funding of the expansion. As of this writing, Starstorm has raised $130,841 out of its original $125,000 goal. And with an additional 23 days of funding to go, it's looking like Startstorm will raise quite a bit more money.
The expansion seeks to add three new heroes (Ted McPain, Sentry and Kree), global chat, twin-stick support, new music and a spectator mode to the game proper. And now that they've reached that goal, a handful of stretch goals can be attained.
Here are the following tiers for the stretch goals:
- $200,000 - New Map and Music
- $270,000 - Custom Games
- $380,000 - Replays and Infinite Spectator Mode
- $415,000 - New Character and Music
- $495,000 - Level Editor and Steam Workshop Integration
- $530,000 - New Character and Music
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- $630,000 - AI Editor


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I've seen religion as an excuse for people to get what they want without admitting to the true reason why they want it. Anti-prostitution laws are supported on moral grounds, but it is widely believed that all women are prostitutes. I am one person who believes that women really only care about money. I suspect that women who wanted to become wives saw prostitutes as unfair competition. I personally would never marry if I could hire a clean, safe prostitute, because although I love women, I know they won't love anything about me other than my money. So by saying extramarital sex is immoral, women saw a political victory, and they were able to have a stable means of income by attaining a prostitution monopoly over one man- her husband. It's just like an inventor who files a patent has a monopoly over his or her invention.
Views: 531
No, Brian, I do not have the wrong idea about you. I don't have enough information to have any valid idea of what kind of man you are. That is why I asked you those questions. Now I know you a little better and can understand you have strong feelings. I don't know what it feels like to you, but it sounds to me as though you have put yourself in a box and nailed the top shut. Some would call that a casket ready for the grave.
One of my dearest friends years ago was a fellow who had been jilted while he was serving in the Korean war and thought all women were as you describe them. He died a lonely old man and lost a lifetime of freedom to explore, experiment, fall in and out of love or find a permanent partner. You can stay in your box if you want to. It is scary out there in the real world. Your heart will be broken (the bad news), and you mend (the good news). That is what life is all about.
Take an imaginary trip to the moon, sit there with your favorite beverage looking at the Earth and thinking about the kind of life you want to have and the kind of man you want to be. Then come back and make that happen. You are you. You are perfectly imperfect. You are the author of your life and your song. Whoever you are is fine with me, as long as you harm no other.
I do NOT agree that all women are after money or they are prostitutes. Men and Women must have equal rights. However, prostitution should be legal and it is up to the women whether to choose this profession or not.
Someone needs a personal coach. These ideas become self-fulfilling prophesy. If you think all partners (women or men) will screw you over, you will not attract the ones who wont. You have to be the man you think your potential partner would want.
I suppose you could settle for a life of masturbation and porn videos. Not very fulfilling as far as conversation and cuddle time, but at least there's no personal betrayal and it's much cheaper.
Interestingly I know gay men who think all men are "whores." It's all a matter of perspective.
I also know a gay man who says gay men are dogs. And a personal coach wouldn't work out. My own mental age is too high.
You're right. I'm afraid all women will screw me over. I don't trust them, and I think they have too much power. I'd rather keep my hands off them than trust one, let her trick me into getting her pregnant, and losing my entire life over it.
Thank you, Ruth. I attempted to respond to your comment below, but the system wouldn't let me because there's either a bug in the implementation or a defect in the design. So I posted my response to your comment here.
I called up my female buddy Nancy and talked to her about your specific above post, among other things. In particular, we considered the possibility that marriage is not right for me. I'm marriage material, but I'm just so afraid a woman won't like me for anything other than my money (when I start dating in 2014/15). Nancy said she thinks I shouldn't get married because she agrees that women just want your money. She says that roughly half of the women are complete gold-digging whores and the other half mostly care about money but also care about other things. We decided that I should instead get a long-term girlfriend. If she's not rich, then she better have no baggage (=no kids). If she's rich, then it's okay if she has kids, because she won't be trying to trap me into financing her baggage and being their second daddy.
I don't despite women. I love women. I have lots of female friends (acquaintances). I even am a teensy bit suspicious of some of their intentions, but it's all cool because that just makes things a little more interesting. Straight women make better friends for me than straight men. Straight men as a group are so competitive, and I don't have a competitive bone in my body. Nor do I enjoy contentious engagement or confrontation. I avoid competition and confrontation whenever I can, even disingenuously apologizing when I shouldn't because words come so cheaply. Gay men do get competitive with me, but not so much. Plus, they're still men, so they have a lot in common with me.
So there will always be a special place in my heart for women. It's how I'm wired, and there's nothing I can do about it. I feel I need to approach the situation with women's interests in mind, and work forward while accepting their desire to perhaps be financially dependent on a financially stable mate if ever need be. Maybe I can be in a relationship with a very gorgeous woman, a woman who I never would have talked to otherwise if she wasn't so pretty. Just like she would never have talked to me unless she already knew I was wealthy. And there are lots of women out there like that. A dime a dozen, even.
As a feminist I disagree with your characterization of women.
I am one person who believes that women really only care about money.
Only in societies where women are barred from ordinary employment opportunities are they economically forced into prostitution. While they are often literally enslaved for this purpose by men, most wouldn't choose such a difficult way to support themselves, so dangerous and so despised, had they other means to feed their children and themselves.
... although I love women, I know they won't love anything about me other than my money.
It's difficult for me to believe that you love women if you can't imagine being loved for yourself. You paint women as less than human, without ordinary capacities for caring. Only by giving yourself credit for being worthy of a woman's love will you discover that we are actually far more capable of reaching out emotionally than men, on average.
If you can't imagine marriage as something far more wholesome and uplifting than a prostitution monopoly, it's unlikely marriage would work for you. You have to give yourself and your wife a chance. Start with mutual respect, a level playing field in which her motivations are assumed to be at least as worthy as your own.
Despising women will not bring you happiness, Brian.
Ruth- please see above for my response to your post.
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Asthma Management: Emotional and Stress Triggers
"When I get extremely stressed out for some reason or another, it tends to trigger my asthma, and I have an asthma attack."
Any kind of emotional response that interrupts normal breathing such as anger, crying, anxiety, depression, or even laughter can bring on asthma symptoms.
But for most people, stress is the most common emotional trigger.
"I've went for my Proventil® quite a few times through stress at work, stress at home, just stress driving down the road. You know, there are a lot of situations that will put you to that spot where that, you know - you just need a breath of fresh air."
Your healthcare provider may advise you to use your quick-relief medication in these situations. Or they might prescribe other medications to help your emotions.
Some people find it helpful to practice deep breathing after taking their medication to get their breathing back on track.
"We need it by the end of the day. Get with me; tell me what you're going to do. Call me as soon as you can. Thanks."
"I try to take slow, deep breaths initially. And if that doesn't work, and it doesn't get my breathing under control, then I definitely have to go and use my fast-acting inhaler."
But in the long run, the most effective thing you can do is learn how to manage the stress in your life.
One approach is to avoid stressful situations whenever possible. For example, if you have a tendency to take on too many commitments, you can learn to say no.
Another approach is to change the way you think about a situation, so that it no longer seems stressful. For instance, instead of letting traffic upset you, you could try seeing it as an opportunity to listen to relaxing music or an audio book.
Using relaxation techniques to reduce your stress level is another great approach. Deep breathing exercises, yoga, meditation or any activity that relaxes your body and mind is beneficial.
Having support is also important. If you're having a problem, talk it over with a friend or family member.
Sometimes it might be helpful to get support from a professional. You can find help on a one-on-one basis, or with a group. Some people find that prayer also helps.
And finally, take care of yourself. Eat right, exercise and get plenty of rest.
By taking steps to manage stress, you'll be less likely to experience asthma symptoms in difficult situations. And you'll be healthier overall.
"You got me smiling..."
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We are looking to crown the best Splatoon team in the region! Your team could WIN a trip to E3 PLUS your own Nintendo Switch consoles!
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- Technical Support
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F(ab')2 fragment antibodies are generated by pepsin digestion of whole IgG antibodies to remove most of the Fc region while leaving some of the hinge region. F(ab')2 fragments have two antigen-binding Fab portions linked together by disulfide bonds and therefore they are divalent. The average molecular weight is about 110 kDa. They are used for specific applications, such as to avoid binding of secondary antibodies to live cells with Fc receptors or to Protein A or Protein G.
Store freeze-dried powder at 2-8°C. When ready to use, rehydrate with indicated volume of d. water and centrifuge if not clear. Product is stable for about 6 weeks at 2-8°C as an undiluted liquid. Prepare working dilution fresh each day. For extended storage after rehydration, add an equal volume of glycerol (ACS grade or better) for a final concentration of 50%, and store at -20°C as a liquid. Note: after the addition of glycerol, the concentration of protein and buffer salts is one-half of the original. Alternatively, aliquot and freeze the product at -70°C or below in the absence of glycerol. Avoid repeated freezing and thawing.
Expiration date: one year from date of rehydration. However, the expiration date may be extended if the product is stored according to the recommendation and the test results are acceptable for its intended use.
1:20,000 - 1:400,000 for ELISA and Western blotting using enzyme-conjugated streptavidin
1:500 - 1:5,000 for enzyme immunohisto/cytochemistry
1:200 - 1:1,000 for flow cytometry and fluorescence immunohisto/cytochemistry
Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.
Biotin-SP is our trade name for biotin with a 6-atom spacer positioned between biotin and the protein to which it is conjugated. When Biotin-SP-conjugated antibodies are used in enzyme immunoassays, there is an increase in sensitivity compared to biotin-conjugated antibodies without the spacer. This is especially notable when Biotin-SP conjugated antibodies are used with alkaline phosphatase-conjugated streptavidin. Apparently, the long spacer extends the biotin moiety away from the antibody surface, making it more accessible to binding sites on streptavidin. Biotinylated antibodies require an additional reagent for visualization. We offer streptavidin and Mouse Anti-Biotin conjugated to fluorophores and enzymes.
This product is for IN VITRO RESEARCH USE ONLY. It is not a medical device and it is not intended for diagnostic or therapeutic purposes.


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Wildlife of Onomea
Onomea Bay and Hawaii Tropical Botanical Garden is home to many forms of wildlife in addition to our plant collections.
Gold Dust Day Gecko
The Gold Dust Day Gecko (Phelsuma laticauda laticauda) is from Madagascar and has become an island favorite due to its dazzling colors.
They can be seen almost anywhere in the Garden, Hilo and the Kona side too. The Gold speckles on its neck make it easy to identify.
One frequent visitor to the Garden is the 'Auku'u, or Black-crowned night heron (Nycticorax nycticorax ). Black-crowned night-herons are native not only to Hawaii, but to just about everywhere else in the world too. They can often be seen picking Tahitian Prawns from Onomea stream.
Mynah Bird
Another Bird that can often be seen is the Common Mynah (Acridotheres tristis). In Hawaii, where the Common Myna was introduced to control pests in the sugarcane fields.
'A'ama Crab
Climbing the rocks by Turtle Point you can spot the A'ama Crab (Grapsus tenuicrustatus). It is a very rapid runner and can travel with great speed over steep and overhanging rocks.
This edible species is often used as food.
Tahitian Prawns
Tahitian Prawns were first brought to Hawaii for food on Moloka'i and O'ahu. Its young were able to travel to other islands and now inhabit Onomea stream. These fresh water shrimp can best be seen in the Garden near the foot of Onomea Falls.
First introduced into the Hawaiian Islands in the 1880s , the small Indian mongoose, Herpestes auropunctatus, is often seen scurrying about the undergrowth of the garden. The sugarcane plantations brought them to Hawaii in an attempt to control rats in the cane fields. Unfortunately, this was a failure because mongooses are diurnal and rats are nocturnal. Whoops!
The Sphinx Moth
Frequently, in the Garden you can hear Visitor?s exclaim, "Was that a Hummingbird I saw?"
The answer is no.
Hawaii does not have Hummingbirds, what they have seen is a moth. Two species of Sphinx Moth's, Macroglossum stellatarum and Macroglossum pyrrhosticta (pictured above), are often seen feeding on various plants in the Garden.
Garden spider (Argiope appensa)
This introduced spider is easily seen on all the Main Hawaiian Islands in a wide variety of habitats from coastal areas to upland forest. The species is black and yellow and about 2 - 2.5 inches long in the female and brown and about 3/4 inch in the male.
Webs are constructed between branches, bushes, human constructions and anywhere that prey might be captured. The webs are often large and have a white zig-zag of webbing from one corner to the center.
Hawaiian Hawk 'Io (Buteo solitarius)
The Hawaiian Hawk or 'Io, Buteo solitarius, is endemic to Hawaii and can sometimes be seen circling the skies above Onomea searching for prey.
Hawaiian Monk Seal (Monachus schauinslandi)
The Hawaiian Monk Seal, Monachus schauinslandi, is an endangered seal endemic to the Hawaiian Islands and one of the most endangered marine mammals in the world. They are protected under the Endangered Species Act (ESA), Marine Mammal Protection Act (MMPA), and state law in Hawaii.
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text: On 10/9/07, Jeffrey B. Layton <laytonjb at charter.net> wrote: > > The recent emails from rgb and Doug lead me to a question. Has anyone > tested codes running under a VM versus running them "natively" on > the hardware (native isn't a good word and I hope everyone gets my > meaning)? The last word I heard is that performance takes a substantial > hit if you are running a code in a VM. Some of the reasons are that the > code has only virtualized access to the hardware (particularly the NICs) > and memory management is a bit more difficult (although Barcelona with > nested page tables should help there). I do remember VirtualIron saying > that they had IB drivers so that the VM had direct access to the hardware. > > Thanks! > > Jeff > > _______________________________________________ > Beowulf mailing list, Beowulf at beowulf.org > To change your subscription (digest mode or unsubscribe) visit > http://www.beowulf.org/mailman/listinfo/beowulf I have done this with ParallelKnoppix, on a cluster of 2 2X Xeon 64 bit machines. Running 4 MPI ranks on a 4 node completely virtualized 32 bit PK cluster using VMware server is about 70-80% as efficient as a real 2 node PK cluster running 4 MPI ranks. That's one data point, so worthless by itself that I won't bother describing exactly what I did. Michael -------------- next part -------------- An HTML attachment was scrubbed... URL: <http://www.beowulf.org/pipermail/beowulf/attachments/20071009/538a8836/attachment.html>


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Illusive Creations needed a new logo design and created a contest on 99designs.
A winner was selected from 95 designs submitted by 35 freelance designers.
Calgary Real Estate Direct
Real estate company launching new design.
Average home buyers 18-40
Color scheme can be seen here with the new design:
The company is called Calgary Real Estate Direct, I would like to place emphasis on the "direct" part of the logo, stay away from the same old real estate logos with the stick houses or small houses in the logo. The logo really needs to stand out and emphasize our brand.
Find out how a design contest works or learn more about our logo design services.