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Monday, April 19, 2010
*HOT* Classico Coupon!
Coupons.com has another awesome new coupon for $1.50/1 any Classico Pasta Sauce 44oz. I used zip code 90210. Better hurry, this coupon will likely go fast!
There is also a coupon for $1/2 any Classico Pasta Sauce 15 or 24oz HERE
Happy Savings!
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Sea Salts Are Good For You!
What do you get when you evaporate sea water? Sea salt is the obvious answer. When the water completely evaporates, you will be left with the salt along with its minerals. Sea salt may contain many of the crucial minerals which your body would require for optimal health and fitness. The more minerals the salt contains, the more colors it may have. The colors may range from sandy, gray and pink, dependent upon where the salt came from. The salt is not going to increase your blood pressure level, but it may help stabilize it. Below are a few popular sea salt examples.
Epsom salt is regarded as the popular bath salt. There is definitely a lot of positive aspects in salt for the bather. It changes the water osmotic balance so your pores and skin will take in a lesser amount of water by way of osmosis. This may reduce or avoid the prune look which you could get when in contact with water for an extended time.
The mineral magnesium sulfate, an element of bath salts, possesses an anti-inflammatory impact. A few of the bath salts, like phosphates, possess a detergent action that would soften your calluses and help in exfoliation.
Himalayan salt is gathered within the Himalayan mountain ranges. Himalayan salt is really a top quality salt which provides 84 minerals, this is regarded as the standard with regards to essential trace minerals and elements. This reveals not merely how pure the Himalayan Salt is, but also the health benefits related to it. This salt truly comes right out the Earth and is unrefined and unprocessed.
Pink Himalayan salt has lots of uses other than cooking. It's utilized traditionally in lots of natural treatments, also in health spas throughout the world. Himalayan salt can also be applied to masks, scrubs and lots of other health spa remedies. When utilized in a bath, it pulls out toxic compounds and may help overcome an exhaustion or illness, by supplying all the necessary nutrients, it may help balance the electrolytes and enhance blood circulation.
Mediterranean sea salt, more popularly known as Dead Sea salt, is 100% natural. The salt content of Dead Sea is 29%, whereas the other sea water is 4%. Containing minerals that are fantastic for the skin, Dead Sea salt products and solutions would definitely be the most effective to keep your skin clear and young. Our recovery products include both Dead Sea Salt, and various salts from the Mediterranean Sea.
For more information on our Sea Salts, have a look at How It Works.

subset: commoncrawl


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Watch 620 Commercial Free Online. Stream and Download The Full Movie 620 Commercial For Free Online
|>>Watch Free: Link 1
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|Title: 620 Commercial
|Year of Release: 1980
|Last Updated:
|Tags: commercial
|More Info: IMDB + TMDB
Where Can I watch 620 Commercial For Free? Now a days there are many sites available for free to watch 620 Commercial online. Now a days we prefer to watch 620 Commercial online because for offline first we have to download and then watch it, but for online we can see right now.
Behind the scenes of a set where people are making a thirty-second commercial for the launching of a common useful product. The disproportionately large number of pieces of equipment - which are not always visible in the commercial itself - is shown with tongue-in-cheek irony.
This 30 second commercial was made for the Doritos Crash the Superbowl Contest. The commercial stars a young man who goes to a party and is having a horrible time. He goes to the restroom and is given a bag of Doritos. He takes a bite and what happens? A FIESTA!
How do you direct a commercial? The director is commissioned to make the latest TV commercial for Harley-Davidson and their respected motorcycles. It requires artistic vision, leadership, and talent. None of which our director has.
A behind-the-scenes look at the making of a commercial for a charter high school in Indianapolis. Students star in the spot, and students worked hands on with the crew behind the camera. The objective of the project was to provide lessons in communication, organization and leadership using the commercial set as a platform.
Watching this crazy gangland send-up with the "outlandish" commercial interuptions, makes you feel as if you are viewing a late night movie on local television, but, a t.v. station could "never" air anything like "Striptease Baby Dolls From Cleveland Meet The Unkillables", and the commercial spoofs are done the way we'd "like" to see them . It's zany comedy and action, laced with beautiful girls
This film is a study of the complete insincerity that is blatant in lots of advertising. Having worked in commercial post-production for quite some time, i may be more sensitized to this stark difference between commercial hype and reality. So in order to maximize this disparity, i had Tristan Mckharmic make the most absurd claims by selling the one thing that may possibly be least likely achiev
Panair do Brasil revives the story of the most important commercial aviation company in Brazil, between 1930 and 1965, with its commercial daring in establishing routes to the four corners of a continental country, taking the adventure of air transport to never-before imagined places, as well as the first international routes. Four decades after it closed its doors, it still retains a marked pre
The Big Rock Eddies: A documentary that goes behind-the-scenes of this amateur Canadian beer commercial competition, which is now in its 16th year and going strong. This comedic character study follows six groups of producers on their quest to create a television commercial that will appeal not only to Big Rock but to their select panel of judges. Ultimately these producers are competing to qual
Rick is an editor under pressure. While editing a commercial the hard disk inside his computer fails and takes on an imaginary life of its own. It transports Rick inside the project that he edits and he begins to live within both worlds; the real and the commercial. When he introduces his wife Jasmin to this discovery, the cracks in their relationship begin to fracture.
Rick is an editor under pressure. While editing a commercial the hard disk inside his computer fails and takes on an imaginary life of its own. It transports Rick inside the project that he edits and he begins to live within both worlds; the real and the commercial. When he introduces his wife Jasmin to this discovery, the cracks in their relationship begin to fracture.
There are many Free and paid sites to watch 620 Commercial online . And some of sites you have to login or signup but there is also some sites where login or signup is not required to watch 620 Commercial for free.
Here's a list of free movies that are related to 620 Commercial.
Here's a Random Selection Of Free Movies


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Most of us own a smartphone, and if you're anything like me your cameral roll has over 29,000 (I'm not kidding). I use a lot of these photos on my personal Instagram account. Instagram is such a fun and amazing community of people! I know a lot of us enjoy making our photos look nice, so I figured I'd share what I do to edit mine!
I use the following apps:
- Retouch
That's it!
- So first you take a photo you want to edit. Remember: photos are easiest to edit if taken with natural sunlight. So outdoors, or by a window with the subject facing the light. Using artificial lighting (indoor lighting) and/or no lighting at all can make photos orange and grainy. I'll use this photo from the park the other day.
- Then you choose your filter. I use the "A Series" filters. Most of the time I use A6, but I also use A8 and A9 depending on what the picture is of. (A6 is good for images that are majority white, A8 brings the green hues down and blue hues up, so is good for images with a lot of grass/plants, A9 brings in more saturation with tan/orange tones, giving it a vintage look). So for this photo I used A6. Click the "paintbrush" icon to get to your list of filters.
- Next, you'll click the "wrench" icon. Here you can mess around with things like brightness, contract, sharpness, etc. Click the half colored circle (contrast) and select desired setting. When you're finished click the check mark on the far right side.
- Next click the triangle to edit sharpness. Select desired setting.
- Next, and this step only applies if your image is crooked. You will click the rotate image. Try to make your image as straight as possible.
- Next, and this is the most important step in my opinion, you will edit the vertical and horizontal perspectives. This makes the image look DEAD, STRAIGHT ON. Haha, I don't know how else to describe it.
- Once that's done, go ahead and click the bottom right hand check mark in the main menu, which should take you to your library and from here click the three dots "…" in the bottom right hand corner and click "SAVE TO CAMERA ROLL".
- Now we're going to open up the app, Retouch. This is completely optional and is only used to "photoshop" or get rid of unwanted objects, etc. Once you open up Retouch, go ahead and click "Open photo from gallery" and click the image you just saved into your camera roll. When it asks for you desired image resolution, I always choose the highest option.
- Once that's open click the paintbrush on the bottom toolbar. Use your finger to trace over the areas you want to get rid of. Remember you can zoom in and out and also change the size of your brush to better the outcome. Once that's done, click the "play icon" labeled start to the right of the hand icon. Click the floppy disk icon on the far right of the toolbar, save to camera roll and TA-DA!
Here's a before and after:


text: The 940 equal division divides the octave into 940 equal parts of 1.277 cents each. It is uniquely consistent through the 11-limit, tempering out 2401/2400 in the 7-limit and 5632/5625 and 9801/9800 in the 11-limit, which means it supports decoid temperament and in fact gives an excellent tuning for it. In the 13-limit, it tempers out 676/675, 1001/1000, 1716/1715, 2080/2079, 4096/4095 and 4225/4224, so that it supports and gives the optimal patent val for 13-limit decoid. It also gives the optimal patent val for greenland and baffin temperaments, and for the rank five temperament temperament tempering out 676/675. The non-patent val <940 1491 2184 2638 3254 3481| gives a tuning almost identical to the POTE tuning for the 13-limit pele temperament tempering out 196/195, 352/351 and 364/363.


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So, the thing about blogging is, we get weird questions and shit. Solicitations. You know.
Let me save you the suspense: No, I don't want to "trade links". But thanks for asking.
And if you want me to "add your link" because I seem like Little Miss Nice About Those Things, you're probably in for a surprise. Like — well, let's call her "Mae." Continue reading


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Home > WIC > New Hampshire > South Newbury
Are you looking for WIC in South Newbury NH? There are many Women, Infants, and Children (WIC) offices in South Newbury, New Hampshire.
Typical Central Office and County Health Department Hours: (Please always call and confirm hours)
M-F 8:00 AM to 5:00 PM


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Life's fuller music will give forth rejoicing tones when heart meets heart, where all lovely gifts and pure are laid upon befitting shrines. Joy hath a living fount, a bliss forever. The heart hath vainly sighed, What shall the future be? This is the future; heaven will be thine, but when its Life shall come no man knoweth, not "the son but the Father." Our sins are not forgiven (until forsaken),* here or hereafter; for every sin there is a just measure of misery, and death cannot advance our joy, nor make us wiser, better, or more pure. The Science of all being must be learned ere this is won. Bliss is not the boon of one brief moment. After the veil has dropped, we have to learn the same as now our way to heaven, by slow and solemn footsteps, for no man cometh to the Father but through Truth and Love. Mary Baker Eddy
(Carpenter, Gilbert, Fragments Gathered From Unpublished Items Ascribed to Mary Baker Eddy, p.66)


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What is a custom URL?Custom URL is a unique, short, and easy to remember web address for your Google+ profile that links directly to your profile or page. So, for example, My Urdu Blogger can direct people to google.com/+myurdublogger to get to their page rather than https://plus.google.com/101682363986581843856.
Why you need a custom URL?A custom URL makes it easier for people to find your profile on the internet. Usually, when you create your account, Google+ used a long ID at the end of URL, which is hard for people to remember. That is why you need to create a custom URL for your account. Google+ custom URL lets you quickly point folks to your profile or page (no more long URLs!)
How to get a custom URL for a Google+ ProfileYou can create a custom URL to make a short, easy memorable web address for your Google+ profile. Before claiming your custom URL, you must meet the following criteria to be eligible to apply for a custom URL. There are only some requirements to keep in mind when you are trying to get a custom URL. If you are having trouble, make sure:
- You must have minimum ten or more followers (people who have added you to their circles)
- Your account must be at least one month old
- You have uploaded a profile picture/avatar
- Your profile has a cover photo (optional)
- There should not be any strike on your account
- Your account is in good standing
Check to see if Your Google+ Profile or Page is Eligible for a Custom URL and Claim itLog in to your account and go to profile you will see a dark gray bar saying "Your profile qualifies for a custom URL [Claim URL] under your account's cover photo. Click on [Claim URL]
plus.google.com/+yourcustomurlOnce you this confirm custom URL, you can't change it again or transfer the URL to someone else.


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The Royal Tour of Southern Rhodesia 1953
Extracted, OCR'd and recompiled by Eddy Norris for use on Our Rhodesian Heritage blog only.
By Astley Hawkins
On 30th June, 1953, Her Majesty Queen Elizabeth The Queen Mother and Her Royal Highness The Princess Margaret set out from England for their second visit to Southern Rhodesia, a British self-governing territory lying between the Zambesi and Limpopo Rivers in South-Central Africa. In 1947 the Royal Family travelled to Southern Africa in H.M.S. Vanguard, pride of the Royal Navy ; this year, the Queen Mother and Princess Margaret flew in the famous Comet jet-airliner, the pride of Britain's Civil Aviation. H.M. the Queen and the Duke of Edinburgh (above) were at London Airport to see the Royal tourists depart, as were Lord Swinton, Secretary of State for Commonwealth Relations, and Mr. Oliver Lyttelton, Colonial Secretary. Princess Margaret (below) turned to give a last wave as she followed her mother into the plane. (Below) the Comet in flight.
Princess Margaret waving t onlookers.
Comet aircraft
This map shows the position of Southern Rhodesia in Southern Africa
Southern Rhodesia's Coat of Arms.
Queen Elizabeth the Queen Mother was magnificent at every stage of her long and tiring 1,500-mile journey, which took her right through the self-governing Colony that is this year celebrating the centenary of Cecil Rhodes, its founder.
Nothing was too trivial for Her Majesty to see and to discuss, no one among all the hundreds of thousands who saw her was too insignificant to be noticed. The Africans in their isolated villages and the Africans of the towns are still discussing her friendliness. They responded to this wholeheartedly, and showed by their lack of self-consciousness that she had their full trust.
However, on the part of the Africans there was still some slight restraint in demonstrating their
How different was the picture only a day or so later. When the Royal party boarded the Royal train of fifteen freshly painted, ivory-white coaches the following evening, there were some signs that the African people were beginning to overcome their first shyness.
The Royal party travelled in three air-conditioned coaches which had been used for the 1947 tour of South Africa. The colour schemes in the bedroom compartments of the Queen Mother and of Princess Margaret were identical—blue and beige with bird's-eye maple panelling.
The adjoining bathrooms had lime-green porcelain and cream walls. English bath crystals and soap tablets were provided— verbena for the Queen Mother and carnation for Princess Margaret. Both bedrooms had built-in radios and dressing tables with long mirrors and cut glass dressing sets.
he lounge dining car was panelled with native South African hardwoods and had a fitted beige carpet and armchairs. Twelve beige leather cane back chairs were placed around the polished hardwood table. Between the lounge and dining sections of the coach was a well-fitted bar tended by Glasgow born Senior Steward Robert Matthews, now serving his 27th year with the Rhodesian Railways.
In the kitchen of the Royal train were special delicacies flown out from Britain for the journey. Supplies of the Queen Mother's favourite China tea and preserved ginger were in the larder; and the chef, Michael Vlotman of South Africa, who had cooked for the Royal family at Victoria Falls in 1947, was storing Scotch salmon and Dover soles in his refrigerator.
The first dinner party aboard the train included both these dishes as well as chicken consommé, asparagus, roast Rhodesian turkey, and apple meringue. The Queen Mother's favourite sherry and white wines were also served. Around the walls were anemones, delphiniums, daffodils, violets, roses, and gladioli to match the different colour schemes.
A corner of the lounge on the Royal Train. All furniture was made from indigenous wood ; the chairs were upholstered in fawn and green brocade, the chesterfield suite in tapestry moquette. The Queen Mother's bedroom (below) was furnished in bird's-eye maple.
The Queen Mother (below) with the Mayor of Bulawayo, Colonel C. M. Newman, when the Royal tourists arrived at Bulawayo, 3rd July. In 1947 the Royal Family paid a 3-day visit to Bulawayo.
Bulawayo's Coat of Arms
The thoughtfulness of the Queen Mother throughout the whole trip was evidenced when she ordered that some of the delicacies from the Royal kitchen should be shared with the newspapermen and others travelling in the pilot train.
Later on, when she was at Government House, Bulawayo, it came to her ears that some of the passengers in the pilot train had not had sufficient blankets for the cold night atmosphere of the mountains. Extra blankets were immediately supplied and a few days later the Queen Mother inquired about it again and was pleased to hear that the travellers were now more comfortable.
It was on 3rd July that the Royal train reached Bulawayo for the opening of the Rhodes Centenary Exhibition. Large crowds had gathered to watch the Royal procession, and here the spontaneous enthusiasm of the people really showed for the first time. Four little European girls pointed the way. Despite the guards lining the route, they skipped into the road in the path of the Royal car and held up posies of flowers.
The Queen Mother's car slowed down, and it appeared as if her chauffeur intended to swerve round the little group of children. But at a word from the Queen Mother the car stopped and one child, six-year-old Margaret Plathen, whispered to Her Majesty: " From Convent High School, please," as she handed up roses and sweet peas with two boxes of chocolates, which bore pictures of the Queen and the Duke of Edinburgh.
"Thank you very much," Queen Elizabeth smiled as she took the gifts, and the police escort led the youthful deputation back to the roadside.
Before leaving Queen's Ground, where the Queen Mother {above) in her opening speech conveyed a message from the Queen, the Queen Mother and Princess Margaret were each presented by Colonel Sir Ellis Robins, Chairman of the Exhibition Board, with a diamond brooch {below, right), fashioned like a flame lily. The flower, {below, left), varies from pure yellow to a dark purple red.
In the British South Africa Company's pavilion at the Exhibition, on 3rd July, the Royal visitors (below) inspected a relief map of the new Central African Federation of Southern Rhodesia, Northern Rhodesia and Nyasaland.
But the crowd broke ranks in me station approach and it was only with difficulty that they were forced back again. Their cheers brought smiles to the faces of Queen Elizabeth and Princess Margaret, who waved and bowed to the excited people on either side of them. The Queen Mother was in white, wearing a crepe costume coat, cuffs trimmed with ostrich feathers, and a small off-the-face white hat also trimmed with ostrich feathers. She wore a three-strand pearl necklace and pearl earrings. Princess Margaret was wearing a beige silk poplin dress and a small beige coronet hat with a diamond brooch.
During their tour of the Exhibition {above) on 4th July, the Queen Mother and Princess Margaret visited the National Pavilions where they received many gifts, including these fine drums from Uganda {below). Also in the Uganda Pavilion, the Princess {below) was very interested in " Peggy," a leopard cub. At the Mozambique Pavilion {below) the Royal visitors were met by attendants in picturesque costume. All countries in Africa south of the Sudan took part in the Exhibition as well as the United Kingdom, Madagascar, Reunion, and Zanzibar.
For six hours during the previous night the Royal train had been halted on a siding at Dabuka, near Gwelo, 100 miles from Bulawayo in order that the Royal visitors might have an undisturbed rest. But all the time the train moved on during the rest of the night, farmers and farm workers, who had travelled in some cases scores of miles to see it, waved as the coaches went by.
I watched from the windows of my own coach and saw them standing beside the line, huddled in blankets against the cold of the night, but springing to life as the white coaches approached.
The Queen Mother brought a message from the Queen when she formally declared open the Rhodes Centenary Exhibition, after the Royal car had passed round the circuit of Queen's Ground, which was packed with 20,000 people including many European and African school children. Africans in all kinds of colourful dress stood in the stands and waved flags or clapped with their hands raised above their heads.
It had been intended that the Queen Mother should open the main gates of the exhibition by pressing a button on the dais in Queen's Ground, but instead she drove a mile and a half to the gates while Africans ran alongside her car as is their traditional manner of greeting a chief.
From the dais the Queen Mother spoke to the great crowd. The message from her daughter can " I have such happy memories of my visit to Southern Rhodesia in 1947 that it gave me real pleasure to become the patron of this exhibition which my mother is to open today. I wish all success to it and continued prosperity to the three territories."
At the African Model Village, which was one of the most interesting features of the Rhodes Centenary Exhibition, the Queen Mother (above) was presented with a beautifully carved piece of ivory. Her Majesty and the Princess Margaret also watched native blacksmiths at work (below), using the techniques which have been handed down the centuries. In another part of the village they inspected a wide variety of basket work, and wood and horn carving. African handicrafts from many parts of the continent were represented in the Model Village which drew large crowds of spectators.
Northern Rhodesia's gift to the Queen Mother was a shallow, circular dish of highly polished copper on a low base. Princess Margaret received a set of nine bowls, each highly polished inside but of unburnished copper outside.
As mother and daughter went slowly round the exhibition there were renewed expressions of loyalty from the crowds. The people pressed in on the Royal party, and the police had to link hands to keep a passage clear for them to walk. African onlookers danced with delight as the Queen Mother repeatedly paused to smile at them. At the end of the visit to the exhibition buildings the Royal visitors rode back to their cars in one of the exhibition's tractor buses.
On 4th July the Queen Mother and Princess Margaret toured the exhibition a second time, and stopped to inspect many of the pavilions of the 18 nations taking part.
Above: In the African Model Village, these native musicians entertained the Queen Mother and Princess Margaret by playing an age old tune on their calabash instruments.
Africans in tribal dress danced and chanted and clapped in ceremonial greeting to the Queen Mother and the Princess as they walked through a native village which was part of the exhibition. Some of the women dancers threw themselves so close to the Royal party that the Queen Mother and the Princess were almost forced to step back. There was no mistaking the pleasure that this expression of affection gave to the visitors, however, and their smiles in turn delighted the dancers.
From music to dancing ! Swazi dancers in the African Model Village (above) put on a special performance for the Royal guests. Later the same day the Queen Mother and her daughter went to a Mayoral Garden Party in Bulawayo Park, where {below), they met widows of Rhodesia's pioneers. The next morning they attended Divine Service at St. John's Church (below), where they were welcomed by the Bishop of Matabeleland and the Archdeacon, the Venerable E. Aldington Hunt.
Although the people of Bulawayo had hoped that the Royal visitors might make the Sunday pilgrimage to the tomb of Cecil Rhodes outside the city, they had been informed that it was not part of the programme. There was considerable surprise therefore when the Queen Mother and Princess Margaret climbed half a mile up into the wild, rocky Matopo Hills to attend a centenary service at the grave. Five thousand pilgrims applauded them as they took their seats near the flat granite slab which covers the grave of the pioneer who gave his name to Rhodesia.
Throughout the service a keen wind whipped across the rocky summit, buffeting the Royal party. It was no doubt this wind which brought on the cold that caused Princess Margaret to curtail her part of the tour.
Wailing pipes playing laments accompanied the pilgrimage to the Rhodes grave, and the stone slab was gradually hidden beneath wonderful wreaths of flowers, including those from the Queen Mother and Princess Margaret, many Rhodes scholars, and tributes from America.
Earlier the Royal visitors had attended divine service at St. John's Church in Bulawayo, and immediately afterwards the Queen Mother and the Princess drove off to visit the Barham Green Village for Coloured People and an old people's home where some of the pioneers of Rhodesia now live.
During a drive in Bulawayo on 5th July, the Queen Mother and Princess Margaret stopped to visit Queen Mary House, St. Gabriel's Home (above), where the Principal introduced some African members of the staff. At St. Gabriel's too, the Queen Mother (below) chatted to the children—one little boy picked a flower from her posy!
The Royal tourists also stopped at Barham Green Village (below), a recently developed Housing Estate for coloured people.
The Queen Mother and Princess Margaret were radiant figures at the Gala Performance of the Halle Orchestra in Bulawayo on 4th July. The Theatre Royal, where the performance was held, scats more than 3,000 people, and was specially built for the Rhodes Centenary Exhibition.
Although the afternoon of Sunday, 5th July, had been left free of official engagements for the Queen Mother and Princess Margaret, Her Majesty and her daughter joined a pilgrimage to the grave of Cecil John Rhodes (above), repeating a visit made in 1947. Cecil Rhodes was buried in the living rock of Malindidzimu in the Matopos hills, 25 miles south of Bulawayo.
One of the last engagements for Queen Mother and Princess in Bulawayo was a visit to Luveve African village, where they were greeted by a brass band (above) and by singing and dancing African women (below) who had journeyed to Southern Rhodesia from the Belgian Congo. Luveve provides accommodation for about 500 families; a notable feature is that it has not been found necessary to establish a police force of any kind in the settlement.
At Luveve, where the Southern Rhodesian Government has provided two schools, a clinic and a post office, the Queen Mother (above) talked with European welfare workers. Luveve was the native name of a former Chief Native Commissioner, Lt.-Colonel C. L. Carbutt, and means " butterfly."
On 7th July, the Queen Mother and the Princess began a tour of the Midlands towns, starting at Gwelo, where unfortunately no photographs were taken of the Royal Visit.
There the Queen Mother opened the Memorial Gates at Chaplin School, met airmen from the Royal Air Force station at Thornhill, and leading Africans from Gwelo and the
surrounding districts. At a morning tea party the Royal visitors met some of the few remaining pioneers and pioneers' widows and inspected detachments of Scouts, Guides, St. John Ambulance Brigade, and Red Cross. The geographical centre of Southern Rhodesia, Gwelo is developing rapidly industrially.
After Gwelo, the next halt in the tour of the Midlands towns was at Que Que (above), a mining and industrial centre, where again, unfortunately, no photographs were taken of the Royal Visit. Here Her Majesty and Her Royal Highness met the Mayor and Mayoress and leading Europeans and Africans.
GATOOMA And HARTLEY
Gatooma and Hartley were the last stops in the tour of the Midlands towns. At Gatooma, a mining and industrial town, Princess Margaret above) received a bouquet from a little girl. At Hartley, one of the earliest Euro- pean settlements in the country, the Queen Mother (above) chatted to one of the town's oldest inhabitants.
Umtali, the " Eastern Gateway" to Southern Rhodesia, was reachcd on the 8th July, and there, on the morning of her arrival, the Queen Mother performed one of the most interesting ceremonies of the tour—the unveiling of the statue to Kingsley Fairbridge at Christmas Pass. Kingsley Fairbridge, who lived in Southern Rhodesia until he went to Oxford in 1908, was the originator of the Fairbridge Farm Schools in Australia, one of the most successful child migration schemes. The Fairbridge Memorial College near Bulawayo, though run on somewhat different lines, was inspired by his ideals. Fairbridge spent the last ten years of his short life— he died in 1924—in charge of the first of the Australian schools at Pinjarra.
The unveiling ceremony took place in a rugged siting near the main road leading to Umtali. The Queen Mother and Princess Margaret, accompanied by Mr. B. D. Goldberg, Chairman of the Memorial Committee, and Mrs. Fairbridge, the widow of Kingsley Fairbridge, who had travelled from Australia specially for the occasion, walked a short distance {above) to the little clearing where the statue (above, left) stands. The Minister in attendance was Mr. E. C. F. Whitehead, Minister of Finance and Posts and Telegraphs. At the memorial site the Royal visitors met many of Umtali's townsfolk and farmers and miners (below), and at Christmas Pass (below) spoke to many boys and girls from schools in the town and surrounding areas.
At one stop Her Majesty met Sister Constantia, an 89-year-old member of the Dominican Order, who is a veteran of the siege of Mafeking and who had met Cecil Rhodes.
At night the Royal visitors left by train for Gwelo, and there was excitement among the party when it was announced that a lion was roaming the line ahead. But although there were signs of an unusually large amount of big game roaming the area, the Queen Mother and Princess Margaret were disappointed. Not one wild animal was seen throughout the whole trip.
Gwelo is the centre for the country's industrial midlands. Here the Queen Mother, again dressed all in white crepe, met men of the Thornhill station of the Royal Air Force, the last remaining camp in this area and a reminder of Gwclo's part in the Empire Air Training Scheme of the last war.
African women, chanting and dancing, encircled the Royal car as the Queen Mother and Princess Margaret (above) drove into Sakubva township, Umtali, on 8th July. In the Moffatt Hall, Sakubva (below), the Queen Mother met members of the African Women's Club and their children. Her Majesty also visited the bungalow of an African family and in the small kitchen showed great interest in a dressing table decorated with newspaper cut into patterns.
During the afternoon of the 8th July, the Queen Mother and the Princess attended the Mayor's Garden Party at Hillside Sports Club, Umtali. Here, the Queen Mother (above), received from little Delyse Levy and Alan McGregor a " walkie-talkie " doll for Princess Anne. The doll's clothes were made by parents of children attending the Fairbridge Centre at Umtali. At this stage of the tour—halfway in both time and distance—the Royal tourists had covered 750 miles and had travelled from Salisbury to Bulawayo, near the western borders of Matabeleland, and then across the country to the eastern borders of Manicaland.
Thursday 9th July was scheduled as a day of rest for the Queen Mother and the Princess at the picturesque Leopard Rock Hotel (above), in the Vumba Mountains. For the Princess it became an enforced rest. Her Royal Highness had contracted a severe cold and had to stay in bed. It was decided that she should fly back to Salisbury instead of undertaking the 200-mile car journey to Fort Victoria scheduled for the following day.
The Queen Mother (below) is seen with the Governor and Lady Kennedy at Leopard Rock Hotel.
Travelling alone to Fort Victoria on 10th July, the Queen Mother stopped at the Nyanyadzi Irrigation Project, and was welcomed (above) by African chiefs from Manicaland, in their red and purple robes of office. With the Queen Mother is Mr. L. Powys-Joncs, Secretary for Native Affairs. At the Irrigation Project about 300 African plot holders produce an astonishing yield of a variety of crops.
Children also seem to flourish at Nyanyadzi! During her tour of the irrigation project the Queen Mother {above) saw and met many Africans of all ages, and was specially interested in African cattle (below). Nyanyadzi, started in 1930, comprises 745 acres under irrigation. The alluvial soil is of great depth, in sections approaching 70 feet. Maize is grown in summer, followed by sunnhemp and wheat in the winter.
At the single-span, 1,080-feet-long Birchcnough Bridge, which carries the road from Umtali across the Sabi River to Fort Victoria, children were again out in force to greet the Queen Mother as she halted on her journey to Fort Victoria. Many of the children had travelled hundreds of miles from the surrounding agricultural districts. It was at Birchenough Bridge (above) that Her Majesty saw her first baobab tree (below), one of the most fascinating of Rhodesian trees. Its grotesque ugliness gives it a charm of its own.
blue robes. One of them, a wizened man of 80, was wearing a 1947 Royal tour medal on his chest. The Queen Mother noticed that he was wearing it back to front, and turned it over for him with a smile. In the afternoon there were visits to three other industrial towns—Que-Que, Gatooma and Hartley.
There were scenes of tumultuous enthusiasm for the Queen Mother at ever)' stop along the route of her 215-milc drive to Fort Victoria, the oldest European settlement in Southern Rhodesia. People had driven many miles to see her, and at one point the convoy of cars was slowed almost to a standstill while Africans, beating drums and carrying palm fronds, sane and danced.
On 9th September, 1891—barely a year after the Pioneer Column had entered the wild and savage country which l3y north of the Limpopo - the Dutch Reformed Church founded Morgenster Mission, which the Queen Mother visited on 10th July. Her Majesty chatted with African nurses of the Mission (above), and inspected the Mission's own printing works (below), where Africans produce church literature. In 1950 the translation of the Bible into Shona was completed.
certainly there is indisputable evidence that gold was smelted there many centuries ago. The Queen Mother also visited the oldest and largest Dutch Reformed Church mission in Central Africa. It was founded in 1891 in a country of hostile natives and is today a flourishing settlement famous for having translated the Bible into the Shona language.
Weird granite outcrops are found throughout Southern Rhodesia, but the " Finger Rocks " at Morgenster Mission (above) are among the strangest. The Queen Mother met the 91-year-old Dr. Andrew Louw, who founded the Mission, and was shown around by the Superintendent, the Rev. Mr. van der Merwe. The large pillar bears a plaque commemorating the Mission's golden jubilee in 1941. The early days of the Mission were difficult, but generous gifts were given by Cecil Rhodes and by the British South Africa Company.
On 12th July, Princess Margaret, who was now recovering from her cold, went to Salisbury Station to meet the Queen Mother, who had journeyed overnight from Fort Victoria. While awaiting the Royal Train, the Princess (above), met Salisbury citizens, including Mrs. F. J. Lovatt, wife of the town Clerk. In attendance was Mrs. W. A. E. Winterton, wife of the Minister for Trade and Industrial Development. As from 12th July, the Princess accompanied her mother to all the remaining engagements in the official programme. Salisbury is built round the site where the Pioneer Column ended its march into Mashonaland in September, 1890.
At Salisbury station on 12th July, the Queen Mother and the Princess Margaret said farewell to the staffs of the Royal and Pilot Trains. Accompanied by Mr. L. W. Lane, Chief Superintendent for Transportation, the Queen Mother chatted to the African staff (above), and also to the Royal Train chefs (above). Later the Queen Mother and Princess Margaret visited the Town House, Salisbury, where the Princess (below) is seen greeting one of the leading members of the African community. The Queen Mother is seen with Councillor S. W. Sandford, the Mayor.
On Monday morning 12th July, the Queen Mother and the Princess attended Divine Service at the Cathedral of St. Mary and All Saints (above), which is the Cathedral Church of the Diocese of Mashonaland. The Cathedral stands on the site where the Pioneer Column outspanned in 1890. The first church was a thatched hut, the second a wood-and-iron building. The architect, Sir Herbert Baker, drew his inspiration for the design of the present building, which was started in 1913, from Ravenna, in Northern Italy, where the influences of both Basilican and Byzantine styles have been felt. After attending the Cathedral service, the Queen Mother and the Princess (below) drove, with a mounted escort of the British South Africa Police, to Harari Township.
At the mission blind children sang for the Royal visitor, then she visited a park laid out by African girl guides to commemorate the Coronation of Queen Elizabeth II.
By the following morning Princess Margaret had recovered from her cold sufficiently to take Holy Communion at Salisbury Cathedral and to be at Salisbury station to meet the Royal train when it pulled in. She greeted her mother inside the coach and remained in the train for 20 minutes before coming back to the platform with the Queen Mother to meet more than 50 members of the Royal train staff and police. Among the staff were a number of African police whose job had been to patrol parts of the track when the train was stationary at some overnight stops.
While in the train Princess Margaret had changed from a brown ensemble to one of all white for the church service which she attended with her mother when they left the train. The service was again held in Salisbury Cathedral, which had been built on the site of the thatched hut that was the city's first church 60 years ago.
After the service the Royal car drove for two miles through Salisbury's African township of Harari. Fifteen thousand Africans lined the streets and cheered.
At the uncompleted buildings of the new hospital for Africans and Asiatics the Princess unveiled a plate, naming the place the Princess Margaret Hospital for Asians and Coloured People of Mixed Races.
In the afternoon the Queen Mother inspected 400 men of the Rhodesian African Rifles, and presented the regiment with its colours in sunshine so strong that several soldiers collapsed during the ceremony. She was dressed in a blue and lilac printed chiffon dress with a wide-brimmed pale blue hat swathed in navy blue tulle.
The Queen Mother compared the significance of the regimental colours with that of the shields carried into battle by the African forefathers of the soldiers on parade. " In the short history of the Rhodesian African Rifles," she said, " you have proved that you can hold your own in battle. By your service since the war, you have shown that you can carry out your duties towards the Queen, the colony, and its people with smartness and efficiency. By the way in which so many of you volunteered to serve in the Middle East when help was needed, you have shown that you are ready to take your share in the welfare of the Commonwealth."
On 13th July, the Queen Mother (above) laid the foundation stone of the Rhodesian University. Expressing her pleasure that the ceremony marked a long period of preparatory work, Her Majesty said : " I hope that the standards and traditions established in this university will be as sound and strong and enduring as the Rhodesian granite of this foundation stone." In the afternoon of the same day, Her Majesty and the Princess attended the British South Africa Police Sports. The Queen Mother (above, right) was presented with a brooch in the form of the Corps' badge and Princess Margaret (below) received a specially bound copy of " Blue and Old Gold," a record of the B.S.A. Police.
Arriving at Mrewa, to attend the Mangwende Agricultural Show on 14th July, the Royal visitors (below) were greeted by this " praise-dancer."
Women trilled the " pururudza " ululation, and the " kawumbere " - the traditional clapping welcome—echoed among Mrewa's granite hills when 16,000 Africans welcomed the Royal visitors to the Mangwende Reserve at Mrewa. Her Majesty (above), received a fine leopard skin from Chief Mangwende and, after the presentations, Princess Margaret (below), accompanied by Mrs. Mangwende, laid the foundation stone of the African Women's Club. In the Queen Elizabeth Hall, the Queen Mother and Princess Margaret (below) were shown some of the work of the Women's Club by Chief Mangwende and his wife.
This delightful picture of the Queen Mother and Princess Margaret with the Governor, Sir John Kennedy, was taken on 13th July at Government House, Salisbury, where nearly 1,000 young people from all over Southern Rhodesia attended a ball for Princess Margaret.
Watching the Salisbury tobacco auction - the world's largest—on 15th July, the Royal visitors (above) were astonished at the speed with which the bales were sold—one every six or seven seconds - and by the auctioneer's " sing-song " chant as he recorded the bidding.
On 16th July, the Royal Tour of Southern Rhodesia ended. In sixteen memorable days the Queen Mother and Princess Margaret had (among other engagements) inspected 14 Guards of Honour or detachments of ex-Servicemen, Guides and Scouts, visited 12 African settlements, made seven replies to addresses of welcome, delivered three speeches, and attended two Government House receptions. Then came the farewells. The Queen Mother {above) shakes hands with Mr. P. B. Fletcher, Minister for Native Affairs. Princess Margaret (left), watched by Sir Robert Tredgold, the Chief Justice (centre) and Mr. Fletcher, says good-bye to the Prime Minister, Sir Godfrey Huggins. Then the Royal visitors (below) boarded the Comet for the flight to England.
Salisbury in the city park, Her Majesty spent over an hour talking to people who had helped or officiated at functions during the tour. She presented cuff-links to the men, and brooches to the women, as souvenirs.
There remained the homecoming. At London Airport on the morning of 17th July, Queen Elizabeth The Queen Mother and Her Royal Highness The Princess Margaret stepped from the Comet jet-airliner (above), to be greeted by Her Majesty the Queen and the Duke of Edinburgh (below). The 1953 Royal Tour of Southern Rhodesia had ended.
End of Publication
Hard copy of the original publication was made available to ORAFs by Canon Bill Girard. Thank you Bill.
Thanks also to Mrs. Lynda Rushby who brought the hard copy to Pretoria and thereafter for taking it back to Canon Bill Girard from England.
Comments are always welcome, please send them to Eddy Norris at firstname.lastname@example.com


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There are a lot of conflicting articles out there about Animals and Essential Oils. I would like you to know that some are safe, and yes, some are toxic. We must do our homework about quality, purity and all of the Chemical Constituents in the Oil.
So if you are looking for an additional ways to help support your animals health naturally, join me! There are so many great options using Essential Oils. This workshop will introduce you to Essential Oils and their amazing benefits to us! Our Main focus will be on our furried loved ones!
From their Anxiety, to Burrs and Splinters, even Motion Sickness! We will go over some must have Essential Oils for your animals, and some great Do-It-Yourself Recipes!
We will also be making a few amazing items for our furry loved ones to take home with you!
1. Calming Blend
2. Flea and Tick Spray
3. Animal Specific Shampoo
I will have all the ingredients, so all you need is to bring your questions, concerns and your note pad!


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Cant Download Google Earth On Mac
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Business Technology News and Commentary. Archived Information. Week Radio. Join us for a roundup of the top stories on Information.
Week. com for the week of September 1. We'll be talking with the Information. Week. com editors and correspondents who brought you the top stories of the week to get the.


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A great review by local food critic Dara Moskowitz Grumdahl of Minnesota Monthly Magazine:
Order from the more-affordable sections of the menu and you'll find the same quality that Little Szechuan became known for with its first restaurant in St. Paul. Be sure to try the ground chicken with pickled bean sprouts—it's tangy, spicy, and invigorating. Compared to the St. Paul location, this new one tends to dish up food that's less aggressively spicy, but it's so pleasant to dine in this sophisticated space that it's a welcome trade-off. I'd say if you're a connoisseur of Chinese food, it's worth the drive from anywhere in the metro to try these unusual, extravagant dishes. And if you're a business person needing to formally entertain Chinese clients, this should be your top choice among local restaurants, bar none.


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School is going to be out for summer time vacation soon and lots of parents is going to be wondering how to have their kids busy and happy. Activities that keep kids from being bored are crucial for summer time vacation. Keeping children physically active is the easiest method to have them from becoming bored his or her heart pounds and vitality flows through their physiques. One activity that's fun and allows them to melt away a few of the natural, abundant souped up that kids have is dance classes.
Dance classes will also be a terrific way to help shy children overcome a few of their insecurities. Most dance teachers are educated to help children uncover their inner potential, finding hidden confidence within them, just like a beautiful jewel that's brought out from deep inside a mine.
Hanging out dancing within the summer time may also combat another inclination during summer time vacation – the inactive syndrome. Keeping the children from becoming lethargic, near the television, gaming or lazily texting buddies is really a challenge that today's parents face and could be counteracted by physical movement. The benefit dance has over other kinds of activities is it's creative side. While sports focus your brain on developing physical skills, dance comes with an additional advantage of allowing a young child to understand more about their inner creativeness because they connect the movement of the physiques for their emotional and inventive heart.
When buying a dance class, enable your child learn about all of the different types of dance available to allow them to choose something they feel they'll enjoy. That can make them more prone to wish to go and also to stick to it. You can view dancing shows on tv to determine what styles appear to carry their interest. You may also look for videos on the web to uncover variations. Do not assume what your son or daughter is going to be interested and you'll be amazed!
Signing your kids up for any dance class can keep you from hearing "I am bored" again and again. They may also be learning something they can transport together through their lives. Some children might even become so enthralled having a summertime dance class that they may wish to funnel their new passion into year-round activities for example musical theater or dance competitions.
Once you discover all of the fun the children are getting, maybe Mother and Father will enjoy to take a few training too!
When you are looking for the best dance classes for kids in Singapore, look no further than the AQ Dance. Whether your kids want to learn dancing for a long time or just as a hobby during their vacations, we offer various packages and programs to choose from.


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Recovery manager organizes End Heroin HSV walk
Every single day, Huntsville emergency crews respond to a drug overdose. While that may not impact your daily life, it does impact our community in a big way. "His Way Recovery Center" Recovery Manager David Wilbourn knows this is true.
Wilbourn found himself in a downward spiral during his college years.
"Didn't too much care for school and was more focused on how I get more Oxycontin, more Oxycontin," Wilbourn said.


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2019 Toyota Tacoma Price, Redesign, Changes
2019 Toyota Tacoma – The third era of the Tacoma was discharged by Toyota in 2015 so it is a generally new model. Regardless of that, the truck didn't generally figure out how to awe its purchasers. It isn't the most effective or even the greatest out there. Over that, its underpinnings depend on its forerunner, so it isn't as great to drive or as fit as a portion of its opponents. With a specific end goal to take care of a portion of these issues, it would appear that another model will be discharged sooner rather than later. So far this is just talking yet it would appear that the truck to offer the overhauls will be the up and coming Toyota Tacoma.
The case is relied upon to be redesigned marginally to be more inflexible than previously. It would seem that Toyota will accomplish this by offering a completely enclosed the casing. The body, then again, will even now be made out of steel and not out of aluminum like on its future opponents.
This will mean the amended Tacoma will be somewhat heavier. In any case, it will likewise flaunt better suspension parts and better axles.
Rather, Toyota is relied upon to refine the present plan keeping in mind the end goal to offer an impeccable or about immaculate medium-estimate truck.
There is a decent shot for the up and coming 2019 Toyota Tacoma to look generally the same as previously. In the front, the truck will probably get another grille and potentially as a new arrangement of headlights.
Be that as it may, the hood, bumpers and even the taxi configuration will continue as before.
This will be genuine just for the normal forms, however. It would appear that Toyota may discharge a TRD Proform with undeniably forceful guards, a raised suspension framework and considerably beefier haggles.
This will likewise get one of a kind shading plans and potentially an alternate bed which would enable the Tacoma to sparkle. An on-street execution rendition has additionally been reputed for an extremely prolonged stretch of time yet this is extremely improbable now.
The present Tacoma offers an exhaustive arrangement of highlights that should cover a large portion of its clients. The updated 2019 Toyota Tacoma is likely not going to change much inside for the most part, therefore.
This is relied upon to end up the primary medium-measure truck to offer a completely advanced bunch which ought to give impressively more data to the driver.
The infotainment framework will offer things like Android Auto, CarPlay and a much better equipment than its ancestor.
2019 Toyota Tacoma Specs
The base model of the 2019 Toyota Tacoma is likely going to include the same 2.7 liters normally suctioned inline-four as its forerunner. Offering around 170 drive and 180 lb-ft of torque, this will be scarcely sufficient for a great many people. The one most will go for will be Toyota's new 3.5 liter V6.
In the modified Tacoma, the bigger motor will probably give around 300 drive and 270 lb-ft of torque
The power increment would enable it to tow more than its forerunner while likewise offering an undeniably usable torque-bend. Them two are relied upon to be mated to a similar 6 speed programmed as previously.
The huge change for the new Tacoma will be the third motor alternative. Now, this is only talking yet it appears auto will get a diesel advertising.
This will probably be Toyota's new 2.8 liters turbocharged inline-four 1GD-FTV motor. With a variable turbocharger, basic rail fuel infusion, likely an AdBlue framework and a lightweight development, the motor ought to be used for around 177 drive and 330 lb-ft of torque.
Price and Release Date
Toyota Tacoma is an SUV with extraordinary highlights. For the TRD Pro, it is important to remove somewhat more cash, however, go 4×4 romping alternatives are significantly bigger.
We trust that 2019 Tacoma won't be available before the finish of 2018. The cost for the TRD Pro is probably going to be around $ 49,000


text: On the 17th of December, Ahfad University for Women in collaboration with the American University of Beirut (AUB) has organized its 3rd Organic Chemistry Competition (AUW-OC3) that took place at AUW between 124 teams from different universities across Sudan and Africa. The aim of the competition is to transform learning into an educational thrill, enjoyed by both students and non-students alike. Prizes were distributed to the first three winning teams. The competition was sponsored by ZAIN Telecommunication Company.


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FlightStats for iPhone includes a set of travel data features optimized for a touch screen mobile application. FlightStats.com includes a wider range of travel data tools optimized for web and mobile web browsers.
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This weeks readings, while occasionally controversial, have shown how cliometrics, quantitative history and the digital world as a whole have opened up new opportunities for historians to gather and assess vast amounts of data in making conclusions about the past. Websites like IPUMS have made this data even more available for scholars, and as discussed in the Ruggles article, have made it easier to code in demographic conditions as well as census data, making these conclusions even more accurate. However, there is trouble when trying to use the mathematic world to interpret the past.
This trouble is seen in Time on the Cross. When reading this I will say that I felt some of the wording and phrasing seemed a bit sketchy. I had assumed that most of the backlash would come from people who were like me, versed in traditional history and felt that the authors hadn't considered enough of the stories behind slavery, focusing on numbers instead of human beings. However, like Haskell, I was surprised to find that a lot of the backlash came from the way in which the authors calculated their numbers. In his critique of the work, Haskell not only employs economic theory but also traditional historical methodology. One such example is, "Fogel and Engerman note the total absence of large free labor farms in the South and attribute it to the superior efficiency of slave labor. But it might just as well be attributed to the shortage of free laborers and the ideological opposition that slaveowners no doubt would have mounted against an alternative mode of production…" Clearly, cliometrics has its merits in the ability to disseminate large amounts of information in a clear and less time-consuming manner, but when taken out of context, it can bear very little meaning in the study of history.
In an example of using quantitative history in the context of the time period, the IPUMS website linked to a New York Times Article from April 2, 2012 that showed how newly digitized census data has proven that the Civil War death toll was about 20% higher than the numbers historians had been reporting for over a century. By factoring in information such as the type of health care available in the Union and in the Confederacy, high immigrant presence in the armies, and female death rates. However, Dr. Hacker, who came up with the new figures, admits that much of these numbers are based on estimates and assumptions that keep his data from being completely accurate.
My questions from our readings this week stem from the qualifications that each author has made regarding their cliometric and quantitative conclusions. In Time on the Cross, the authors acknowledge that the information they are presenting is controversial, however their contempt for past research into the economics of slavery keeps them from clarifying exactly how much of their data relies on qualifiers and assumptions about the Confederacy. The other authors and researchers make clear that in using data and numbers to make conclusions about the past there tends to be a lot of guesswork, and coming up with an exact, perfect number appears to be nearly impossible. I feel that this connects cliometrics and quantitative history with the traditional study of history in that, when studying primary sources, a historian can never be completely sure that they are getting the entire story. There is always bias or a hidden motive in records of the past, and in that way it appears that no matter if we are using numbers or words, there is always room for error in a historians work.


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One of the many reasons drivers from the Chandler community are drawn to the iconic Subaru brand is due to its reputation of producing fuel-efficient cars and SUVs. Subaru consistently works toward improving fuel economy, and the brand has made great strides over the years as a segment leader in fuel economy. All Subaru vehicles come designed around the Symmetrical All-Wheel Drive (AWD) system created by Subaru, with the exception of the Subaru BRZ sports car. This feature comes standard across all models and trims of the Impreza, Legacy, WRX, Crosstrek, Forester, and Outback and improves efficiency by distributing power in a more effective way than traditional AWD systems.
Every new Subaru model continues to flaunt improved fuel efficiency over previous versions. Updated engine series have helped propel fuel ratings forward, made more effective with the inclusion of electronic features like Electronic Throttle Control. The Subaru Lineartronic® Continuously Variable Transmission (CVT) also improves efficiency by reducing engine speed as you travel down the highway and also helping you to accelerate quickly from a stopped position.
You may have even noticed that the exteriors of our Subaru SUV and car models have taken on a more sporty appearance in the past few years. Not only does the new styling make our vehicles stand out even more during your adventures, but the new and sculpted exteriors help to increase aerodynamic efficiency, in turn boosting your fuel economy.
Subaru continues to offer highly competitive fuel economy ratings across each segment, and it's no wonder why drivers from Chandler and Phoenix choose an adventure-ready Subaru model for daily transportation. It doesn't just make sense to drive a Subaru – it can actually help you save money over the long run, too. Visit Subaru Superstore of Chandler today to explore our new Subaru vehicles for sale and learn more about the features that make our models an excellent choice!


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The Core Director of the company Prof. Manish Jhaveri, qualified as a Chartered Accountant in 1995. He is an Associate member of the Institute of Chartered Accountants of India. He has a Master's Degree in Commerce as well. Mr. Jhaveri has experience of over 8 years in the field of Foreign Education.
Prof. Manish Jhaveri was associated as a professor with Gujarat University, a leading university of Gujarat as well as India. He teaches at Bachelor's (Graduate) level as well as Master's (Post Graduate) Level. He teaches Accountancy, Management and Taxation courses.
Further Mr. Manish Jhaveri, was associated with PLANET Educational Group as Director. In 2002 Mr. Jhaveri has incorporated Uniworld Education and started promoting Australian and UK universities in India.
Mr. Manish Jhaveri Director of the company, Prof. Urmish Jhaveri, is also a professor associated with Gujarat University. He teaches Graduate as well as Post Graduate students. His specialisation is in Management and Accountancy.
So, Uniworld is promoted by all Professors who are in live touch with students and are aware of importance of education as well as requirement of students.
Uniworld Education is AAERI member, supported by Mr.Urmish Jhaveri Australian Education International at the Australian High Commission, New Delhi.
Uniworld Education is also part of AGENT ZONE of British Council for promotion of Education UK globally.
We are also member of QISAN Quality International Study abroad Network which is International Association having head quarter in United Kingdom with membership no. QVN2005006.


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Jennifer Aniston, nursing a broken toe, needed a cane and a co-star to collect her People's Choice Award.
Aniston, who plays Rachel Green on the hit NBC series "Friends," used the cane and a helping hand from co-star Matthew Perry to walk to the stage of the Pasadena Civic Auditorium on Sunday.
The 33-year-old actress received the award for favorite female television performer during the 29th annual awards show, hosted by Tony Danza.
Aniston broke a toe on her right foot after hitting it on a piece of furniture, her publicist said Monday. He didn't elaborate.


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A new law in Colorado is intended to limit unnecessary idling of trucks.
The city and county of Denver now limit idling to 10 minutes each hour. Gov. John Hickenlooper signed into law a bill to set a statewide idling standard for commercial vehicles weighing in excess of 14,000 pounds.
As of July 1, 2011, affected vehicles will be limited to idling for no more than five minutes per hour.
Communities are authorized to adopt the idling standard. However, local authorities are not required to enforce the state standard.
Supporters said the restriction is needed because excessive truck idling is extremely detrimental to the state's air quality, and costs business more money. The restriction is touted as going a long way in making cleaner air more widely available.
Violators would face fines of up to $150. Repeat offenses could result in up to $500 fines.
The list of circumstances that exempt truckers in Colorado from the restriction is lengthy. Valid reasons to idle include situations when vehicles are stuck in traffic or when idling is necessary to heat or cool a sleeper berth during a rest or sleep period at a rest area, truck terminal, truck stop, or "state-designated location designed to be a driver's rest area."
Truckers getting rest are also exempt from the restriction while parked at a location where the vehicle is legally permitted to park, as long as it is located at least 1,000 feet from housing, a school, a daycare or a hospital.
An exception for cold temperatures kicks in when the thermostat dips below 10 degrees. Under such circumstances, idling will be allowed for up to 20 minutes per hour.
Owner-operator and OOIDA Life Member Jack McComb of Littleton, CO, said as far as idling rules go the new law is reasonable.
"I'm OK with it. If we are going to have an idling law, it is good to see it include enough exceptions to make it a livable law," McComb said.
He also said it will prevent local governments from setting up their own rules.
"One rule in place statewide makes it easier for everybody to know the rules."
Revenue from fines will be distributed between the state's highway fund (65 percent), counties (26 percent), and cities (9 percent).
To view other legislative activities of interest for Colorado, click here.
Editor's Note: Please share your thoughts with us about the legislation included in this story. Comments may be sent to email@example.com.
Copyright © OOIDA


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Whether you have moved into your first home or you dislike the furniture you recently found, it can be difficult to find the right living room furniture in St. John's for your place. You want to be proud of your place when you and your guests step through the front doors. But if you aren't, you can always turn to Furniture Market.
With years of experience in the business, you can depend on Furniture Market to help you furnish your home with furniture that fits it and your preferences.
Our store in St John's serves both residential and commercial property owners. We know just what furniture works best for a number of different spaces and can advise you accordingly. We wholeheartedly recommend our durable, long-lasting couches and recliners.
For more information about our living room furniture, contact Furniture Market. We are happy to answer any questions you have about furnishing your living room.


text: Venice Beach PeopleVenice Beach PicturesVenice Beach Skate ParkVenice Skate Park Picture of the Week Venice Skate Park Picture of the Week 7-22-11 By Bret - July 28, 2011 0 367 Share on Facebook Tweet on Twitter Daniel Delaveaux 7-22-11 Picture by Ray Rae! Click here to check out more pictures! Buy a print!


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Home > IJCCPM > Vol. 12 (2014) > Iss. 2
Article Title
Abstract 摘要
Professor He Huaihong observes that the lives of famous Chinese philosophers in the 20th century were longer than those of their French counterparts and attributes this phenomenon to differences in these individuals' ways of life and guiding philosophies. I broadly agree with Professor He. However, I make a different claim for the fundamental difference between Chinese philosophy and Western philosophy. According to Chinese philosophy, human beings' supreme goal lies within human life, whereas that defined by Western philosophy isexternal to human life. According to modern definitions, humanity's ultimate aim is to construct paradise on Earth through scientific and technological innovation and economic growth. The corollaries of this modern goal are that no single individual can ever be satisfied with her/his situation and that society as a whole can never be satisfied by the level of its economy. In short, modernity legitimizes global greed. As a result, many elites in modern society are greedy. However, greedy people cannot also be happy and unhappiness has been statistically linked with unhealthiness. Before the 20th century, most of China's philosophers were absolutely virtuous and capable of remaining peaceful in any situations, and thus usually enjoyed long lives.


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My junior year of college, in what felt like a seismic life shift for me at the time, I changed my internet homepage from ESPN.Com to Kyle Mooney's YouTube channel, making the world's most lovable awkward-street-interviewer—a PG Sacha Baron Cohen—my electronic home base. Instead of starting my nightly homework procrastination on ESPN, with old, loud, white men debating whether it's OK for players to kneel during the national anthem, I began my nightly homework procrastination by watching Kyle's videos. (I'm also an 82-year-old lady at heart and wasn't aware, then, that you could subscribe to a YouTube channel and get an email notification whenever that channel uploaded a new video. I didn't want to miss anything, so, anytime I opened Safari, I'd see if there was a new Kyle video. And there often was. Because Kyle made lots of videos.)
I say Kyle and not Kyle Mooney or Mooney or Full Mooney because that's what his lifelong pal and cameraman, Dave, always called him from behind the lens. It was Kyle, what are you doing? Or, Kyle, what ARE you doing? Or, Kyle, WHAT are you DOING? With Kyle, there was this established, friendly familiarity: we were already on a first-name basis. Kyle Mooney, we knew less about: we knew that he did sketch work with his pals, Beck Bennett (as in SNL's Putin) and Nick Rutherford (a writer on SNL), after they all met at USC as theater and film dweebs. Their brilliant assclownery even got a response from Stevie Spielgs:
But, mostly, Kyle did performance art-quality, uncomfortable conversations with strangers. Was he a needy exhibitonist? Nope. Was he just a prankster on camera acting dumb? Not really. Was he a comedian perpetually doing a bit? Yes and no. Was he reacting instinctively and purely to whomever and whatever he encountered while supremely grounded in the present? Yes. Isn't that loosely the definition of improv? Yes. I watched all his other videos, daily, and was hooked.
My junior spring, when I was too hurt to race, I rented cameras from the library and went full Kyle with guys from other schools.
Against the UVM Catamounts, I stumbled through questions about "all the kitty cats in the crawly scratchers?" Against the Bowdoin Polar Bears I stumbled through questions about whether "they were by the sinkin'—with the Polar Bears? Feel it?" I went hours being Kyle until one javelin thrower from Bowdoin threw it right back at me.
"Long balls away when they're throwing it at ya? Or is it?"
I stopped, said KYLE, then gave him a hug.
* * *
Last week, I saw Kyle's debut, feature-length film, Brigsby Bear. It's the epitome of a Dram-Com/Dramedy. It's truly weird and dorky, deeply human and sad, and laugh-out-loud funny. That is, I was laughing out loud harder than all eight other people in the theater (It was just me until three 20something bros, a mom with her two college-aged sons, and a 30something couple shuffled in during the opening credits.). For an outside, non-Kyle enthusiast, it might just be chuckle-out-loud or shake-your-head-and-feel-underwhelmed humor. It's beyond quirky and often very dry. But for any Kyle lifer, it's must-see. A host at Comic Con, from a video I watched on the YouTube, called James the "origin story" for Kyle's interview persona, which is a perfect way to think about it. (And yes, I know what you're thinking. You go to the movies by yourself? For the right movies, I love to.)
Without giving away any spoilers, it's a movie about an obsessive dude named James, played by Kyle, who obsessively watches a TV show then obsessively makes a follow-up movie based on the show after the show ends. Both movies—Brigsby Bear as a whole and the movie James makes within Brigsby Bear—are love letters to storytelling and filmmaking. (Unsurprisingly, I resonated with James' obsessiveness towards creativity, and I left the theater feeling more buoyant to make a movie than I have leaving a theater since…?)
It was also produced by The Lonely Island. If Kyle was my biggest creative hero from age 20 to 22, Andy Samberg and his weiner-joke buddies held that same title from 18 to 20. In that way—and a lot of ways—it felt a like a celebration.
A celebration of Kyle (and Dave).
A celebration of the artist who writes the book he's dying to read but can't seem to find on the shelves.
A celebration of the creative plugger, or, as my dad says, those who "stick to their knitting" —for years and years.
Creativity, to rephrase our definition, is the encounter of the intensively conscious human being with his or her world.—Rollo May


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According to recent statistics, most American children under the age of 11 dont exercise as frequently as they should. Even less do so outdoors. Outdoor exercise has been shown to boost kidss physical and mental well being. It also helps them acquire creative cognitive, and psychological skills. Ultimately, participating in healthy outdoor exercise habits, including unstructured playtime by means of a platform tree swing, helps children develop healthful lifestyle habits.
What Are Stage Tree Swings?
Before we discuss children are actively engaged by tree swings and deliver vital physical and mental health benefits, lets make sure that everyone understands precisely what stage tree swings are. A stage tree swing gets its name from two things: the form of swing seat it uses, and in the fact the swing is tethered to a sturdy tree limb for support.
Strap design seats typically found on playground swings, unlike the rubber, platform swings have a level, broad seat thats typically big enough for more or two preadolescent children to sit on simultaneously. The seat can be a rectangle or a square, or it may be circular like the one you discover on the Super Spinner swing. The seat could be generated from durable mesh, high grade canvas, or thick, all-weather plastic, among other substances.
No matter their specific design components, stage tree swings are like normal swings in one respect: They require kids to use physical energy to generate the swinging activity. These are the mental and physical benefits of outdoor exercise for kids.
1. Physical Advantages
Unlike a lot of adults, most children children dont exercise in an exclusive health club or a gymnasium that is public. Instead, they get much of the physical action from playing outside on playgrounds as well as in yards, which will be a great thing as it pertains for their physical well-being. Research has shown that there are at least five crucial benefits of getting regular, outdoor exercise.
Strengthens the Immune System
Outside exercise boosts replacement and immune system cell creation. In accordance with a recent article from FITDAY, Lungs get better equipped at handling oxygen and dishing it out to the remainder of your body [when you work out outdoors]. Furthermore, Doctors have found that exercise can boost your own immune system by providing a boost to the [creation of] cells in your body that are assigned to attack bacteria.
Using stage tree swings to help fortify your kids immune system benefits both you along with your little one. It will help your child avoid missing school and playdates with friends, also it helps you avoid paying for expensive clinical treatment to get your childs health back on course. For less than the expense of just one visit to some doctors office, you can get an incredible stage tree swing.
Helps Increase Lung Capacity
Vigorous exercise from swinging helps increase lung capacity by causing your child to take regular, heavy breaths to furnish the body with a high degree of oxygen when it needs it during vigorous outdoor play. Its the same type of benefit that adults receive when they take routine jogs. The more exercise children participate in, the higher their lung capacity.
Fortifying your little ones lungs can do more than improve her or his swinging experience. It can also help the child succeed in phys-ed actions at school and perform well in independant sports leagues and school sports. If your youngster is involved in baseball, football, or another common sports action for children, swinging can serve as his or her work out that helps enhance performance in the activities, which, in turn, can help encourage self-confidence.
Fine Tunes Vital Motor Skills
Outdoor dangling fine-tunes motor skills as well as physical dexterity by helping children enrich the their grip strength, depth perception, and hand / eye coordinationthree things which might be essential to get a kids safety in actions such as using playground equipment (grip strength), crossing the road (depth perception), and using devices that want a child to look away from them while theyre used (hand / eye coordination).
Developing fine motor skills is one of the very crucial yet commonly overlooked facets of a kids physical development. Treating your son or daughter to hours of swinging fun on stage tree swing straps helps ensure he or even she acquires as they transition into maturity, critical motor skills which are needed now as well as as time goes by.
Produces Sensory Stimulation
Swinging advantages two primary sensory systems: the vestibular system and the proprioception system. The vestibular system has a major effect on physical coordination and controls eye movement and equilibrium. The proprioception system is an automatic sensitivity mechanism in the body that communicates on the way in which the body should respond to specific stimuli, together with the central nervous system.
When these systems dont receive enough stimulus, it could possibly create a child appear physically awkward and delay his / her response time to physical stimuli that must be processed. Like motor skill development, sensory stimulation development also can play a key part in your kids security while he/she participates in day-to-day activities.
Contributes to Long Term Health
Consistently using a swing will help produce a healthful, long-term exercise habit. Studies show that children who start exercise or play habits early are more unlikely to develop health problems later in life. This consists of heart disease a decreased danger of obesity, and diabetesthree health issues that are often found in people who dont get enough regular exercise.
Most parents have heard regarding the obesity epidemic among todays youth, but the problem of obesity can lead to other health complications, like diabetes and cardiovascular disease. Getting your child get regular outdoor exercise with stage tree swings can do more than help him or her avoid learning to be a walking childhood obesity statistic. Additionally, it may help alleviate problems with obesity related illnesses could compromise long term health and potentially shorten ones lifespan.
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September 2018


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Tag: Cabozantinib
Pounds and Workout reduction are cornerstones in the procedure and prevention
June 25, 2017
Pounds and Workout reduction are cornerstones in the procedure and prevention of type 2 diabetes, and both interventions function to improve insulin glucose and level of sensitivity uptake into skeletal muscle tissue. Muscle lysates had been examined for AMPK activity and Akt phosphorylation as well as for TBC1D1 Cabozantinib and AS160 phosphorylation on known or putative AMPK and Akt sites the following: AS160 Ser711 (AMPK), TBC1D1 Ser231 (AMPK), TBC1D1 Ser660 (AMPK), TBC1D1 Ser700 (AMPK), and TBC1D1 Thr590 (Akt). The dietary plan intervention Cabozantinib Mouse monoclonal to ERK3 that contains a major change in the macronutrient structure led to a 4.2 0.4 kg pounds reduction (< 0.001) and a substantial upsurge in insulin level of sensitivity (worth 5.6 0.6), but surprisingly, there is no influence on phosphorylation or expression of the muscle-signaling proteins. Workout increased muscle tissue AMPK2 activity but didn't boost Akt phosphorylation. Workout improved phosphorylation on AS160 Ser711, TBC1D1 Ser231, and TBC1D1 Ser660 but got no influence on TBC1D1 Ser700. Workout did not boost TBC1D1 Thr590 phosphorylation or TBC1D1/AS160 PAS phosphorylation, in keeping with having less Akt activation. These data show that a solitary bout of workout regulates TBC1D1 and AS160 phosphorylation on multiple sites in human being skeletal muscle tissue. > 0.20, the info was regarded as distributed normally. All normally distributed data had been likened using Student's < 0.05. Outcomes Clinical and metabolic features of the topics. The consequences of the dietary plan intervention on subject matter food and characteristics intake are summarized in Table 1. There was a significant change in macronutrient intake through the diet plan treatment. The percent energy intake from sugars was decreased from 48 8 to 5 1, a 90% decrease. Extra fat and protein increased from 32 8 and 19 5 to 59 5 and 36 5, respectively (< 0.05 for all). The caloric intake during the diet intervention was not statistically significant from the prediet. As has been shown in previous studies, this diet causes a rapid weight loss (2). The average weight loss after diet intervention was 4% (4.2 0.4 kg), and this was associated with an increase in insulin sensitivity as indicated by an 30% increase in the value and a small but significant decrease in fasting blood glucose concentrations. The weight loss was composed of a 4% loss of lean body mass and 3% loss of fat mass. There was also a significant decrease in plasma triglyceride concentrations, whereas cholesterol concentrations were unaffected. Human skeletal muscle expresses multiple splice isoforms of TBC1D1. Mouse skeletal muscles express the short and long splice isoform of TBC1D1, with the long form predominant (31). Interestingly, only the long form contains the Ser660 and Ser700 phosphorylation sites, whereas the Ser231 and Thr590 sites are expressed in both splice variants (3). It is not known whether multiple splice variants of TBC1D1 Cabozantinib are expressed in human skeletal muscle, and therefore, we determined the relative expression of the long and short TBC1D1 splice variants in human skeletal muscle by amplifying TBC1D1 by PCR with splice exon-flanking primers. The amplicons were separated by agarose gel electrophoresis. Two sets of primers each yielded three products (Amplicon DNA level: 1:0.41:0.28) (Supplemental Fig. S1; Supplemental Material for this article is available online at the website). Sequencing results confirmed that all three amplicons are splice variants of TBC1D1. The short-form TBC1D1 is missing the entire splice exon (SE) domain, whereas the medium form Cabozantinib lacks only the NH2-terminal part of the SE domain in TBC1D1. Our results suggest that three splice variants of TBC1D1 are expressed in human skeletal muscle. The weight of the short form is predicted to be 140 kDa, the medium form 146C148 kDa, and the long form 155 kDa. As shown in Fig. 1and and and F). Muscle glycogen and GLUT4 concentrations. Muscle glycogen concentration is a major regulator of skeletal muscle tissue glucose transportation (10, 13). The 2-wk Cabozantinib diet plan intervention, that was composed of low carb consumption, significantly decreased muscle tissue glycogen concentrations (Fig. 4A). The solitary bout of severe workout significantly decreased muscle tissue glycogen concentrations both before and following the diet plan treatment (Fig. 4A). GLUT4 manifestation was not altered by the dietary intervention (Fig. 4B). Fig. 4. A: glycogen content was measured in biopsies taken before (open bars) and after 30 min exercise on a cycle ergometer at 70% of V?o2 max (closed bars) in the pre- and postdiet conditions. Postdiet glycogen levels were reduced compared with … DISCUSSION Understanding the mechanisms by which exercise and dietary interventions stimulate glucose transport could lead to novel treatments for metabolic illnesses such as for example type 2 diabetes. Right here, we studied.
A meningococcal group B vaccine containing multiple proteins antigens including element
June 6, 2017
A meningococcal group B vaccine containing multiple proteins antigens including element H binding protein (fHbp) and Neisserial heparin binding antigen (NHba) is in clinical development. anti-NHba and anti-fHbp antibodies taken out more SBA than depletion of either antibody individually. Mixing up a mouse Cabozantinib non-bactericidal anti-fHbp version 1 antiserum using a mouse anti-NHba antiserum also augmented the anti-NHba SBA titer from this check strain. For meningococcal vaccines that focus on sparsely-exposed antigens such fHbp or NHba fairly, non-bactericidal antibodies against person antigens can cooperate and elicit SBA. are in clinical studies currently. Among the vaccines includes recombinant aspect H binding protein (fHbp) from two Cabozantinib antigenic variations [1]. Another includes an external membrane vesicle vaccine (OMV) [2] coupled with three recombinant protein: NadA, and two fusion protein, fHbp in the variant 1 (v.1) group fused with GNA2091 (GNA2091-fHbp), and Neisserial heparin binding antigen (NHba) [3] fused with GNA1030 (NHba-GNA1030) [4]. NHba was known as GNA2132 [5 previously, 6]. In mice immunized using the three recombinant protein, the main antigenic goals of serum bactericidal antibody (SBA) had been fHbp, NHba, and NadA [4]. The mix of the three protein also elicited higher SBA titers than the specific protein by itself [4]. In human beings a vaccine using the three recombinant protein (no OMV) also elicited SBA replies [7] however the contributions from the antibodies elicited by the average person antigens toward the noticed SBA had been unclear. Looking into the functional efforts of specific antibody populations in an assortment of serum antibodies could be difficult due to the positive or detrimental connections of antibodies binding to multiple antigenic goals over the bacterial surface area [8C10]. The goal of the present research was to specify the function of antibodies to two from the antigens, nHba and fHbp, in eliciting serum bactericidal activity in immunized human beings. Genes encoding both of these antigens can be found in every disease-causing meningococcal isolates [1 almost, 11C14]. 2. Methods and Materials 2.1. Human being serum examples Stored serum examples were obtainable from six Rabbit polyclonal to ZNF280A. adults immunized intramuscularly with an investigational meningococcal vaccine that included recombinant GNA2091-fHbp, NHba-GNA1030, and NadA [4]. The examples were chosen from 36 sera previously investigated from mature individuals of phase I research primarily made to evaluate vaccine protection and tolerability [7]. The individuals received 3 doses from the vaccine spaced a month aside. Each dosage included 50 g of every from the three protein adsorbed with light weight aluminum hydroxide. Blood examples were obtained instantly before the 1st immunization and a month following the third immunization. All topics provided informed created consent. For today's research, we chosen serum examples based on option of sufficient quantities for the adsorption research described below. Usage of the serum examples for this study was approved by the institutional review board of Childrens Hospital & Research Center, Oakland. 2.2. Mouse serum samples Stored sera were available from previous experiments in female CD-1 mice (Charles River) immunized with a recombinant NHba Cabozantinib vaccine (gene from NZ98/254) [6], or a fHbp ID 1 vaccine. The amino acid sequences of the respective vaccine antigens matched those of the NHba and fHbp components of the vaccine given to the humans [4]. For the mouse study, three injections were given, each spaced 3 weeks apart. The fHbp dose was 20 g, which was adsorbed with aluminum hydroxide, and the NHba dose Cabozantinib was 15 g, which was given with Freunds complete adjuvant for dose 1 and incomplete adjuvant for doses 2 and 3. Control mice received the respective adjuvants without the vaccine antigens. Blood samples were obtained 3 weeks after the third dose of.
Signalling by the TGF-β superfamily member and BMP orthologue Decapentaplegic (Dpp)
April 17, 2017
Signalling by the TGF-β superfamily member and BMP orthologue Decapentaplegic (Dpp) is vital for multiple developmental programmes and Cabozantinib has to be tightly regulated. that a dual system settings Cabozantinib SMAD degradation. Therefore in addition to being an obligatory component of the cap-dependent translation initiation complex eIF4A has a novel function as a specific inhibitor of Dpp signalling that mediates the degradation of SMAD Cabozantinib homologues. To understand the rules of Dpp signalling we have previously recognized a dominant-negative mutation in eukaryotic translation initiation element 4A (eIF4A) which functions as a suppressor of haploinsufficiency1. This allele embryo2. To investigate whether mutations cause improved Dpp signalling in general we examined the effects of mutations on Dpp signalling in additional developmental or genetic contexts. First we found that and (a null allele1 3 dominantly suppressed the sterility of females that were doubly heterozygous for null mutations of and (and females laid morphologically normal eggs that hatched to viable adult progeny (Table 1) indicating that reducing the amount of can compensate for a reduced maternal and dose for embryonic viability. Second and dominantly suppressed the partial lethality and 'solid vein' phenotype that was connected Cabozantinib with reduced degrees of the sort I receptor Thickveins6 9 (Fig. 1a; Desk 1) indicating that the result of mutations on Dpp signalling isn't limited by embryogenesis. Third transient ectopic appearance of induced by light heat surprise was tolerated in wild-type flies but led to lethality within a dominantly enhances the consequences of ectopic appearance (Desk 1). heterozygosity likewise enhanced the consequences of overepxressing with the eye-specific (find below and Fig. 1h). Mutations appear to augment the Dpp signalling power Cabozantinib Therefore. Figure 1 Degrees of eIF4A have an effect on Dpp signalling and Mad proteins amounts. (a) Adult wings of different genotypes are proven anterior aspect up. Take note the 'dense blood vessels' (arrows) in the wing as well as the suppression by or augment Dpp signalling To research at which stage lack of eIF4A boosts Dpp signalling we analyzed the degrees of energetic or phosphorylated Mad (pMad). In early wild-type embryos pMad indicators Cabozantinib are detected in temporal and spatial patterns that are correlated with appearance10. At stage 10 pMad indicators had dissipated in the procephalon and posterior midgut of wild-type embryos (Fig. 1b; also find refs 10 11 but had been still discovered in embryos (Fig. 1b) – a phenotype that's nearly the same as that due to lack of DSmurf11 CDC42 – indicating an extended length of time of Dpp signalling. Pronounced elevation and extension of pMad indicators were also discovered in stage 11 (find Supplementary Details Fig. S1) and stage 13 embryos (Fig. 1c). In keeping with the higher amounts and extended domains of pMad indicators we discovered that appearance in gc and ps7 which is normally at the mercy of positive autoregulation was also expanded in embryos (Fig. 1d). Once we recognized expanded domains but little or no ectopic pMad and the initial pattern of or pMad at phases 5-6 was not obviously changed in embryos (data not shown; observe Supplementary Info Fig. S1) the presence of higher levels and expanded domains of pMad signals in later embryonic phases indicate a prolonged Mad activation in embryos. To understand the cause of the long term Mad activation we examined Mad protein levels in embryos. Mad protein levels are generally low in all cells including ps7 in wild-type embryos (Fig. 1e; remaining). However in embryos elevated levels of Mad protein were found in ps7 (Fig. 1e; right). The observed build up of Mad protein is consistent with the idea that Mad protein levels are normally negatively controlled by protein degradation and mutations disrupt this process. Interestingly the higher levels of Mad protein that were recognized in embryos seemed to be nuclear localized indicating that may interfere with the degradation of triggered Mad. To investigate whether mutant cells autonomously increase Mad phosphorylation and protein levels we generated cell clones that were mutant for any fragile allele of alleles are not viable3. We examined multiple larval cells and found improved pMad and Mad levels associated with mutant clones most prominently in the presumptive adult gut (Fig. 1f g). These results indicate that mutations cause long term Mad phosphorylation which might be due to reduced Mad degradation. To test whether wild-type eIF4A antagonizes Dpp signalling we indicated using the Gal4/UAS system12. First expressing one copy of from the eye-specific manifestation.


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Then and now // Anniversary photos at the pumpkin patch
Posted by Melissa Skoda on
Two years ago these two lovely humans tied the knot and had their bridal portraits taken at Westham Island Herb Farm.
Fast forward to this year…
they welcomed a new addition to the famiy and celebrated their two year wedding anniversary weekend with a photoshoot at the herb farm. This year was a little more stormy than two years ago so we didn't venture too far into the pumpkin patch as our boots were sinking in calf-deep!
Here is a collection of photos from both shoots; a wonderful idea for beautiful family heirlooms.