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Brian Stelter's "In their own words: The story of covering Election Night 2016"
Be sure to read Brain Stelter's tick-tock of election night through the recollections of a score of reporters and analysts.
I met with publishers the next day and started on The Fourth Way that evening. I never expected it would be needed, but because nobody did, it very much is.
The Economist today gave it a quick but accurate 30,000 foot summary:
Hugh Hewitt, a conservative talk-radio host, this month will publish "The Fourth Way", a book-length guide to how Trumpism might advance bits of the Reagan agenda, by promoting conservative judges, stronger armed forces (Mr Hewitt likes Mr Trump's talk of a 350-ship navy) and free enterprise (above all rolling back "the vast and growing regulatory state"). To that he would add a "repatriation window" for corporate profits held abroad, and a new, voter-pleasing wave of infrastructure projects, including reopened shipyards, modernised airports, local sports facilities and other visible signs of Trumpian largesse. Billions would be disbursed by temporary, county-level commissions appointed by Congress and the White House ("the patronage!" sighs Mr Hewitt) and as classic pork-barrel spending by members of Congress. To break the partisan stalemate over immigration Mr Hewitt would have Mr Trump lay out detailed plans for a double-row border fence along the southern border, which when half- or three-quarters built would trigger a legalisation programme for most of the 11m immigrants in America without the right papers. Get all this right, Mr Hewitt says, and Mr Trump can realign national politics. Get it wrong and Mr Trump could face "catastrophic" midterm elections in 2018, a primary challenger in 2020 or, if embroiled in scandals, impeachment.


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subset: commoncrawl


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Friday, August 17, 2007
A Touch of Heaven (August 8, 2007)
Most of you are frustrated and repulsed by the injustice you can easily see from the government. Have you ever thought that you are not alone and that the spirit of God might be groaning through you to the throne petitioning God to deliver. Magnify your suffering by all those who have passed through this fraud called justice and just perhaps God has heard and seen enough. That is how I see it and like Isaiah's cry to the Lord "send me." I believe He has. If not me who? I don't know of any others who are possessed with the knowledge and faith I've been given. If they have it they have not been given the opportunity. When one has opportunity, faith and tools he is the mark to get the job done. Now if I coward away from such a great calling what will comfort me. I share this with you so that you will no longer shrink back from the opportunities you've been given. You say you're afraid, for what? Fear is nothing but giving up the helps that come from reason. If you knew the words of promise spoken over you because you have kept your ear tuned to the Lord's voice you could reason like a champion and prevail upon your enemies who are bigger cowards than us all. You see them here on the Blog. They have no hope because it is defeated by their inward weakness and they prefer ignorance to knowing what caused the torment.
As you ask how long O Lord will the wicked prevail over me the question returns how long will you not trust me? Why have you stopped pondering on the majesty of the Lord. He is the baddest dude on the block, bar none. Woe to those who defy the living God. Their fate is like that of Goliath. A bunch of hot air released from a gaping throat severed from a head filled with retarded reason.
Now encourage yourselves and know that our enemies are in a state of confusion. I have received good report after good report lately and most of you would think it bad news. I'll give you one example. Our old landlord Hanover has been placing liens upon client properties. This is a sign of desperation. First off my fiduciary position is separate from the party to which they had a dispute. This is a tort in itself. The lawyer and the landlord are throwing money at me. It also means that they have some real issues with the taking of the property, validating what transpired. They are betting the farm on our conviction otherwise they can lose everything. I love it when a plan comes together. You guys are scared but I wish you could sit in on our settlement conference and watch the chief magistrate judge get embarrassed by the prosecution putting him in an impossible situation. He has to get us to believe that the clients are our victims when he is precluded by his own statutes from making them so. The plea bargain is being negotiated around in circles because they have a political agenda not matching up with their procedural remedies. We will be at this again but I suspect the judge will not be suckered as easily this time around. For the first time though we get to pierce the silliness of assault against us. Think about 2 years passing and not one bit of truth ever surfacing and you are afraid of these cowards? Name one brave liar you have known your whole life and then you can give these men some credit.
Let me give you a heavenly view. God growing weary of the complaints of injustice found two men who were brave enough to trust Him. He set up a sting operation disguising them as bait. He lured, in their best mechanic with the most violations Judge Alsup and caused him to dispose these men and to be aggressive for their destruction. Now He presented this as a trial before His courts in heaven and ordered us to allow them to exact all the suffering upon us as discovery and verification. When they refused to allow truth to be presented and to do all within their power to convict innocence He was able to validate His verdict of guilty as charged before He imposes His sentence. If you are like me in this knowledge you are praying that God has mercy on these wicked men and that they come to their senses and come to them soon. We are just about at the signing of the verdict form and then that judgment will be final. Then they will be standing in front of a real judge who knows real justice. No bribes, no pay offs, no twisting the law, true justice. God is answering your prayers and all hell might be breaking loose because of the pending sentence. Take courage and find the joy in your deliverance. It is closer than you can imagine. Those who have faith talk with the Lord and see if this is puffery and wishful thinking. His "amen" should be enough for you to find the courage to finish this race. It is what I do and we can get those new legs for the final sprint together. I want to say I am very proud of those of you who have prevailed in this battle. I'm certain notice has been taken in heaven. Let us all boast in our great Lord who brought us through to the end, and was gracious and merciful to give us the strength for the journey. If God be for us who can be against us? Wicked men afraid of their own shadow? See that the Lord has made you strong and that truth has girded your loins. The belt of truth keeps our guts intact and shores up our inner strength. The Animal Alsup, Darling Dimples Dimke, the Yeller Feller Keller, will all soon know that they cannot contend with the Lord and His justice. You have done well to bet on the sure thing the immutable word of the Living God. Bless you all. "Amen"
16 comments:
- mogel007 said...
"It also means that they (Hanover Properties) have some real issues with the taking of the property, VALIDATING what transpired.
Seems to me the act of Hanover putting liens on properties shows AN AGREEMENT of some kind was come to, otherwise, what right would they have to put liens on properties?
Course putting liens on properties where dorean clients have a beneficial interest puts innocent parties in a damaged situation.
Looks like Hanover properties ALSO took the "bait" and now it looks like the mouse trap snapped back on them.
Hanover properties becomes a co-conspirator to the FBI's illegal seizure of Dorean's bank account monies through their unlawful eviction.
If Dorean prevails, then, the FBI also becomes a party that acted badly too by confiscating of funds that would have paid the rent ontime. However, as I understand it, Hanover properties rejected the bill of exchange that was presented for rent payments to Hanover and evicted anyway since the FBI should have honored payment of the rent timely, since the funds were there to pay Hanover properties when the FBI became a fiduciary of these confiscated bank account funds at the time of seizure.
The bottom line is the money was tendered and rejected for rent, so Hanover properties evicted illegally, so Dorean taking of their office complex was just. A valid tender of payment that is rejected, eradicates the debt: UCC Title 13, Section 3603.
If there is no longer any rent debt, according to the UCC, then Hanover illegally evicted, causing great damages not only to the Dorean Group but to many Dorean clients that couldn't have their bank challenges and all paperwork finished timely and trust booklets sent to them either.
You CAN'T accept rent and then evict anyway!!! Or you can't evict when there is no rent debt any longer.
If Dorean is acquitted of all counts in Federal Court, than validation of Dorean's actions of taking Hanover's building becomes more evident.
Did Hanover KNOWINGLY put liens on properties in Trusts? If so, yes, that shows real desperation doing an illegal act and not caring. Or did Hanover ignorantly put liens on trust properties? If so, they have extremely stupid legal counsel. Either way Hanover Properties are screwed since a tort is created.
- near the end said...
Justice77777 and Nemo and Judge Roy etc....
It's a bummer being wrong is'nt it.
Life in prison Pleaseeeeeeee!!!!
- mogel007 said...
Justice: The Attorney General resigns!!! Dr. Fred was EXACTLY RIGHT PREDICTING THIS EVENT. And you thought he hasn't been right about anything. LOL
I guess Gonzales's lies & incompetency finally caught up to him:
Now with 4 major officers in the cabinet resigning already, DO YOU THINK SOMETHING IS ROTTEN IN DENMARK as the saying goes?
- light1rae said...
My wife and I are so very grateful that we chose to associate ourself with you. Righteousness is hard to find in a man these days let alone two righteous witnesses willing to stand.
- mogel007 said...
"Nice breasticals said the Judge" as he admired the scenery. LOL
Unfortunately it's a felony for a person to tape a persons voice without their knowledge or permission in the State of Florida & also posting the conversation on the internet is also another felony:
- neodemes said...
"Thou wilt keep him in perfect peace, whose mind is stayed on thee: because he trusteth in thee." (Isaiah 26:3)
- near the end said...
Justice77777 This is all way over your head is'nt it.
You to notrial dissent and you to Nemo.
You guys are getting stomped on but don't feel bad.
Kurt and Scott are way above your IQ'S.
Farrell does not deserve a cent from his clients.
- justice7777777 said...
near the end said...
Justice77777 This is all way over your head is'nt it.
Kurt and Scott are way above your IQ'S.
Nah, just sitting back eating popcorn, and continuing to let the idiot brigade of moogie, yourself and a few others set themselves up for a catostrophic failure.
- madtowne said...
- This comment has been removed by the author.
- madtowne said...
How does the current mortgage industry "fall out" effect your plan?
As I understood, simplistically, the "lenders" involved would be liable for payouts. How can they pay if they have ceased operations?
- near the end said...
justice777777; You're not very smart are you.
You said life in prison. WOW were you way off!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
- Dr. Caligari said...
You said life in prison. WOW were you way off!!!
Let me know when they get released, and we'll see.
- near the end said...
watch for yourself.
- mogel007 said...
Justice said: "Nah, just sitting back eating popcorn, and continuing to let the idiot brigade of moogie, yourself and a few others set themselves up for a catostrophic failure."
Sounds pretty positive to me considering this statement is coming from you! At least you have admitted that the plan to date HASN'T FAILED YET since if you are still waiting for a future event of catastrophic porportions, you're still guessing and uncertain as usual.
That's how I like to see you Justice, patiently waiting & guessing. Your "coolness" with no cares of the world, is also becoming or attractive too. I like that!!!
- mogel007 said...
Kurt said: If I culd lodge my greatest complaint among my fellow christians, it is how they coward out in the heat of the trial when THE HEAT was designed to PROMOTE THEM."
"You cannot get what you've never had unless you're willing to do what you've never done."
- notorial dissent said...
Moogey blather follows"It also means that they (Hanover Properties) have some real issues with the taking of the property, VALIDATING what transpired.
Or it might have something to do with Kurt having messed with the title of the Hanover Properties buildings, which they will most likely have to go to court to clear, and let's not forget the rent the boys skipped out on, no, I don't see any reason as to why Hanover would be upset. As to believing what dim and dimmer say is happening, not for a minute, but I will bet Hanover is doing everything it can to recover the losses it incurred.
Dream on Moogs, whether the FBI or the IRS for that matter seized their accounts, it was still dim and dimmer's responsibility to pay their rent, they didn't, and they ultimately tried to defraud their lessor, big surprise. What you understand is surprising little. Having seized funds from the boys, the govt did not magically become responsible or take on any fiduciary capacity for paying their bills, so you can forget that line of bull. A BOE is not, and never has been legal tender, is not money, and in the case of dim and dimmer is the equivalent of a bad check. The lessor was under no obligation to accept it, the bottom line, is that nothing of value was tendered, and the whole collection of justifications you keep coming up with is a crock. In the real world, they call it fraud Moogs. And once again Moogs, you illustrate in great glowing detail you total lack of knowledge about the UCC. IT DOES NOT COVER REAL PROPERTY OR REAL PROPERTY RENTAL, that falls to the state real property statutes. If you don't get your rent, in the manner specified in the rental agreement, you certainly can evict, and that is what was done.
near the end made an indistinct noiseLife in prison Pleaseeeeeeee!!!!
I'm sorry, I don't remember dim and dimmer being released, and so far I see no evidence of a plea agreement, so just what exactly are you crowing about?
Moogs, the only one who didn't know Gonzales was quitting was him. The only question was how long would he remain as an embarrassment before he had to be told to resign.
near the end blathered yet againYou to notrial dissent and you to Nemo.
You guys are getting stomped on but don't feel bad.
So far I see little evidence of anything but a big mouth. Let me check, gee, I'm sitting quietly at home responding to a complete idiot, and gosh, where are dim and dimmer? Why confined in a Federal prison cell. Yep, looks like I'm losing real bad here, I guarantee you I had a much better dinner than they did for starters, and as to IQ, now where am I and where are they, your math is as faulty as your suppositions.


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What We Need
Our client is seeking an Senior Vice President / Client Leadership to join their west coast based team. This position will report to the CEO. The ideal candidate must be a strong strategic thinker, business builder, able to develop strong professional / personal relationships and a developer of people.. This position is a member of the agency's senior leadership team and is responsible for managing and building high profile client relationships, including account profitability and all account management teams serving those clients..
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Sunday, January 10, 2010
Food Roundup (Week 2)
This week's notables:
1. Rice Noodle Roll (Cheung Fun 腸粉)
This snack (pictured left) is cheap (around $10hkd a plate) and tastes sooo good! It's basically a bunch of rice noodle rolls cut into bite sized pieces, served with peanut sauce, sweet sauce and hot sauce which you squirt on however you want. I personally like covering the cheung fun with peanut sauce and then squirting some sweet sauce on the side. SO GOOD!
2. Taiwanese Snowflake Ice @ 糖仁街 China Town Dessert (TST)
Rough translation of the Chinese name for this dessert - 雪花冰. First time I've ever tried or SEEN this and my goodness, it was sooo good. I should have taken a picture of the order form - you choose one flavour for the ice cream base (10+ options), then a sauce/topping, then two sides. I can't remember exactly what we ordered but I think the first one was green tea ice cream with sesame with tapioca balls and exploding mango balls. These are like jelly/tapioca with mango juice inside, so they explode in your mouth when you eat them (SO GOOD!!!) . Second one was chocolate ice cream with cornflakes and exploding yogurt balls and glutinous rice balls (湯圓?). Best. Dessert. Ever.
Notable mention: Mcdonalds Sausage and Egg Mcmuffin (Combo #10)
This is available ALL DAY every day for $9HKD (roughly $1.25 CAD). That is all.
Labels: Food Roundup
3 comments:
- Chung said...
The cheung fun looks soooooo good...
And also, the last time I was in HK I deliberately ate the Filet O'Fish for breakfast and Sausage&Egg McMuffin for dinner, just because I could. Hee.
- January 11, 2010 at 1:39 AM
- Matthew said...
MCDs looks thicker than North America...
- January 11, 2010 at 11:38 AM
- Cherry said...
omg this is so not what i need to see when im trying to go on a diet =(
- January 14, 2010 at 6:41 AM
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- 36pixAsked on October 07, 2015 at 12:55 PM
My email notification fails to reflect the fields I see on screen.
Is there a way to 'reboot' the notification so that it reflects all the data?
For just one example, the field whose properties are {billing}...
If I go back and view the submission- I can see that all the data is there.
- JotForm SupportWelvinAnswered on October 07, 2015 at 02:48 PM
We do not have a reset button in the notification settings so the best way you can fix this would be to re-create the whole settings.
You need to delete the current notifier: http://www.jotform.com/help/132-How-to-Delete-Notifications-Autoresponder.
Re-create it after: http://www.jotform.com/help/25-Setting-Up-Email-Notifications.
This is way easier than manually adding the field names in email body.


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© Pint of Science, 2019. All rights reserved.
Are we on the verge of a post-antibiotic apocalypse? What would the world look like without antibiotics to treat bacterial infections? Perhaps one could forget about these worries with a pint of your favourite craft beer? But how does microbial life affect our favourite brew? Find out more about bacteria, our bodies, and beer with insights from local researchers...
The Post-Antibiotic World
Jessica Minion, MD (Medical Microbiologist, Saskatchewan Health Authority)
Microbes have been evolving on earth for billions of years. Since the advent of antibiotics approximately 100 years ago, they have continued to evolve to meet this new human-made challenge. The development of antibiotic resistance has now become an established, well-described threat to modern healthcare. What are the drivers behind this evolution? Is there anything we can do to stop it? What will the world look like if we fail to respond?
Brewing Science: The "Craft" of Microbiology
Jordyn Bergsveinson, Ph.D. (Post Doctoral Fellow, Institute of Microbial Systems and Society, University of Regina)
Brewing, beer, and yeast require no introduction – they're all part of humankind's most ancient and favourite scientific process! But have you ever wondered what makes today's beer unique from the past? Or what other microorganisms are involved in making (or ruining) your preferred local craft? The world of brewing microbiology is a true "pint of science" – come learn about how brewing has impacted the evolution of science itself and your experience with modern craft!


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From my good friend Sue at the "Thoughts that get stuck in my head" blog
Go to Google and type your name, the plus sign and needs. Then post your top 10 results. (Your name + Needs)
1) Tracy needs wins to get back in title battle
2) Tracy needs to find the right balance between emotions and logic (That's true)
3) Tracy needs a mirror (This is starting to get personal Sue)
4) Tracy needs to pay more in taxes (OK, now we are going TOO far!)
5) Tracy needs your help and debt advice
6) Tracy needs help in paying his hospital bills, medical expenses (such as continued care), medications, counseling and transportation expenses (I guess this is why I need help with debt advice)
7) Tracy needs to do something about Armas Pittsburgh Pirates. (I am not sure what I should do though)
8) Tracy needs a new doctor. (Because the old Doctor caused answer #6)
9) Tracy needs a new addiction. (Because the old addiction along with the Doctor that prescribed it caused #5 and #6)
10) Tracy needs to cut that mess. (I guess this is related to answer #3)
Great, now my self esteem sucks. Thanks Sue! :)


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A wristband handmade from a vintage military shirt sleeve mixed with a selection of mixed inner lining of jackets. It best matches your t-shirt in the summer to add a grunge and stylish touch to your casual wear. In the winter, it blends perfectly with your suit and jackets as an extended layer of cuff, unique and cool.
Measurement: 25cm x 7cm
Fits wrist of 17cm or under
AVAILABLE at
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D. Michael Davis, DVM, MS is an accomplished equine surgeon and has been practicing veterinary medicine in New Hampshire since 1992. He graduated from Colorado State University (DVM) and then completed simultaneous surgical residency program in Equine Surgery and Masters Degree in Veterinary Anatomy at Louisiana State University. After teaching and serving as staff surgeon at the University of Montreal he joined and then became partner at the Rochester Equine Clinic. Dr. Davis' continued goal to provide the practice a facility where quality of service and growth both continue to rise led to the development of this entirely new medical and surgical center.
Jacqueline Bartol, DVM, DACVIM joined Dr. Davis as partner and co-owner of New England Equine Medical & Surgical Center, PLLC. Dr. Bartol completed both her graduate (DVM) and residency training at Cornell University and is a board-certified internal medicine clinician (Diplomate, American College of Veterinary Internal Medicine). She joined Rochester Equine Clinic in 2000 and had been an outstanding contributor to that expanding practice, then joining Dr. Davis in the development of NEEMSC in 2005.
In 2016 Dr. Bartol decided to leave veterinary medicine and explore other career options. She will always be a member of the NEEMSC team, having dedicated so much time and effort to the practice over the course of 10 years. Her expertise, energy and tireless worth ethic will be missed, but we support her as she embarks on new adventures.


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In the News
December 20, 2015
'Drebatizing' Olympia - One Property at a TimeThurston Talk
Thomas Edison once said, "the three great essentials to achieve anything worthwhile are hard work, stick-to-itiveness, and common sense." For more almost five decades, John Drebick and his family have embodied Edison's words while making Olympia a better place to live, work, and shop.
According to the Harvard Business School, "family firms account for two thirds of all businesses around the world." Drebick, who moved into a two-bedroom home in 1957, entered into the real estate industry in title insurance and land surveying. In 1967, he added real estate sales to his resume.
When not working on his properties, John enjoys salmon fishing. Four years later, he opened The Drebick Company in downtown Olympia specializing in residential properties. He then borrowed money from his parents to purchase his first office building for The Drebick Company. John and his wife, Glenda, handled residential sales, property management and commercial real estate brokering.
When times got tough in the 1980s, Glenda took investment services work with Shurgard Mini Storage. When the economy improved, she used her professional skills to join John as an owner of Drebick Investments, LLC. She is a long-time member of the Zonta Club of Olympiawhere she edits 'The Inkling,' their newsletter. John is a member of the Finance, Investment, and Youth Services committees for the Olympia Kiwanis and is quite active in the holiday poinsettia sale.
Leaving the residential real estate business in 1988, they focused exclusively on property management and operations of buildings they owned. From 1985-2000, Drebick Investments, LLC developed and built commercial buildings that were later leased to state agencies and private businesses. Of their four adult children, three are still local and son Stuart runs Adroit Contractors Inc. from an office he built and shares with his dad.
'The Wedge' was created in 2012 near the courthouse campus on Evergreen Park Drive SW. Their West Olympia location is dubbed, 'The Wedge,' which was created in 2012 near the courthouse campus on Evergreen Park Drive SW. Since settling in to these custom-built offices, John Drebick and his team have sold off their developed properties and invested in others across our region. Available space now includes the downtown Les Schwab location, which will be redeveloped, as well as four office buildings near The Wedge, which are Drebatized into "The Quad Office Park" and eight acres of light industrial land in Hawks Prairie.
Once a new property is acquired, it is 'Drebatized' for maximum appeal quality and value. This often includes updating paint, roof, and parking needs, adding natural stone to structure fronts and breezeways, and new landscaping throughout the area. This complete make-over updates older structures and vastly improves curb appeal. For leasing information on any of these established properties, contact Luke Kravitz of Kidder Mathews.
John laughs that the question he's asked the most is, "Why aren't you retired yet?" But why settle down to his fishing, vintage cars, and motor home travel when he's still "interested in continuing to own properties to Drebatize?"
From 1985-2000, Drebick Investments, LLC developed and built commercial buildings that were later leased to state agencies and private businesses. His advice to property owners is simple: there is plenty of empty office space in Olympia, but the ones being leased are those being updated. Why let an outdated commercial building sit vacant when a round of Drebatizing can get it filled up and provide income?
"At the end of the day, I know who I am. I'm a real estate guy," says John. "Our door is always open." He encourages potential renters to contact him directly with development ideas for any of his holdings. By partnering with Stuart's commercial, retail, and industrial contracting business, they can turn something as common as a tire shop into the condo, boutique, or restaurant of your dreams.
Contact John and his team by visiting The Wedge at 1001 S. Evergreen Park Dr SW, calling 360-943-4340, or emailing firstname.lastname@example.com. With more than 50 years experience, he's capable, confident, and always has a story to share.


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Rolls-Royce Phantom II Continental Drophead Coupe
The development of Rolls-Royce Continental models is quite interesting. In September 1930, Rolls-Royce designer Ivan Evernden toured the Continent in a smart new Phantom II sports saloon. This car had been built on Henry Royce's directions, starting with a Riley Monaco saloon as a pattern and scaled up for the PII chassis. The spare tires were moved to the rear, and the wings were flared with their undersides exposed. Fitted with a sunshine roof, it was painted in pale saxe blue and finished with an early metallic-like clear coat made with fish scales. Evernden managed a last-minute entry in a concours d'elegance at Biarritz and came home with the Grand Prix d'Honneur. The car generated quite a buzz and considerable orders, sufficient for the factory to prepare a brochure for a Continental model, which was ready by the time Evernden returned home.
The second Continental prototype was bodied by Park Ward, and Royce was very pleased. A close relationship between the two firms resulted, but Park Ward by no means had the monopoly on Continental bodies. Others were built by Hooper and some, like this car, by Freestone & Webb.
Part of the RM Auctions event at the Syon House in June, 2011 and in London, October, 2012.
7,668 cc overhead valve six-cylinder engine, dual ignition with coil and magneto, four-speed manual gearbox, solid front axle and underslung live rear axle with semi-elliptic leaf springs, four-wheel servo-assisted brakes. Wheelbase: 144".
Source: RM Auctions
Photo Credit: Copyright Tom Wood and KC Squared


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Pleiotropic protective effects of phytochemicals in Alzheimer's disease.
Bottom Line: Recent findings suggest that phytochemicals compounds with neuroprotective features may be an important resources in the discovery of drug candidates against AD.Specifically, curcumin, catechins, and resveratrol beyond their antioxidant activity are also involved in antiamyloidogenic and anti-inflammatory mechanisms.We will focus on specific molecular targets of these selected phytochemical compounds highlighting the correlations between their neuroprotective functions and their potential therapeutic value in AD.
View Article: PubMed Central - PubMed
Affiliation: Clinical Biochemistry and Clinical Molecular Biology Laboratory, Department of Health Sciences, University of Molise, 86100 Campobasso, Italy.
ABSTRACTShow MeSH
Alzheimer's disease (AD) is a severe chronic neurodegenerative disorder of the brain characterised by progressive impairment in memory and cognition. In the past years an intense research has aimed at dissecting the molecular events of AD. However, there is not an exhaustive knowledge about AD pathogenesis and a limited number of therapeutic options are available to treat this neurodegenerative disease. Consequently, considering the heterogeneity of AD, therapeutic agents acting on multiple levels of the pathology are needed. Recent findings suggest that phytochemicals compounds with neuroprotective features may be an important resources in the discovery of drug candidates against AD. In this paper we will describe some polyphenols and we will discuss their potential role as neuroprotective agents. Specifically, curcumin, catechins, and resveratrol beyond their antioxidant activity are also involved in antiamyloidogenic and anti-inflammatory mechanisms. We will focus on specific molecular targets of these selected phytochemical compounds highlighting the correlations between their neuroprotective functions and their potential therapeutic value in AD.
Related in: MedlinePlus
Related In: Results - Collection
Mentions: Curcumin (1,7-bis [4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) or diferuloylmethane is extracted from the rhizome of Curcuma longa [7]. The structure is often shown in the keto form, but recent NMR studies demonstrated that curcumin exists in solution as keto-enol tautomers [8] (Figure 1). Numerous pieces of evidence suggest that curcumin may be a promising therapy for AD because it has different neuroprotective activities, including antioxidant [9], anti-inflammatory [10] and antiamyloidogenic properties [11]. Curcumin has been demonstrated to have a strong antioxidant neuroprotective effects, scavenging ROS [12] and neutralizing nitric-oxide-(NO-) based free radicals [13]. However, one of the issues of curcumin as a therapeutic agent in the treatment of AD is its poor water solubility [14], which is one reason for its low bioavailability following oral administration or through parenteral route [15]. The poor bioavailability is one of the causes of its failure in randomized control trials for AD. The structural features of curcumin that can contribute to the antioxidant activity are the phenolic and the methoxy group on the phenyl ring and the 1,3-diketone system. Moreover, the antioxidant activity of curcumin increases when the phenolic group with a methoxy group is at the ortho position [16, 17]. The orthomethoxy group can form an intramolecular hydrogen bond with the phenolic hydrogen, making the H-atom abstraction from the orthomethoxyphenols surprisingly easy [18]. The H abstraction from these groups is responsible for the remarkable antioxidant activity of curcumin. Moreover, the reactions of curcumin with free radicals produce a phenoxyl radicals and a carbon-centered radical at the methylene CH2 group [19] (Figure 2). Additional experimental reports supporting the antioxidant property of curcumin were provided by Lim and coworkers using an AD transgenic mouse model which demonstrated that curcumin reduces brain levels of oxidized proteins containing carbonyl groups [20]. In vivo, the antioxidant activity of curcumin may be mediated through antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Curcumin has been shown to serve as a Michael acceptor, reacting with glutathione (GSH) and thioredoxin [21]. Depletion in cellular GSH levels is an important measure of oxidative stress, which is implicated in the pathogenesis of AD. A study on postmortem brain of AD patients has revealed decreased levels of GSH in some area of the brain [22]. Also, the GSH levels were low in the red blood cells of male AD subjects, confirming an association between GSH and AD [23]. Noteworthy, there are some studies reporting the restorative effect of curcumin on GSH depletion. For instance, it was demonstrated that curcumin is able to replenish the intracellular GSH pool by changing the nuclear content and/or activation of specific transcription factors such as 12-tetradecanoate 13-acetate (TPA-) responsive elements (TRE) and electrophilic response element (EpRE) [24]. Moreover, curcumin enhances the antioxidant enzyme activities of SOD and CAT in the striatum and mid-brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) injected mice [25]. Taking into account that in vivo evidence showed that peroxynitrite induces Alzheimer-like tau hyperphosphorylation, nitration, and accumulation [26], it was reported that curcumin mediates the direct detoxification of reactive nitrogen species such as peroxynitrite, thus exerting an antioxidant activity [27]. Furthermore, the pieces of evidence to support a role of oxidative stress in AD brain with elevated levels of lipid peroxidation increasing [28]. Oxidative damage of lipids generates toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA) leading to cell death. Important cytopathologies in AD brain include a decreased activity of all electron transport chain complexes [29]. In particular, complex IV decreases in AD, which causes release of oxidants during mitochondrial electron transport [30]. It was reported that excessive Aβ binds to regulatory heme, triggering functional heme deficiency and causing the key cytopathologies of AD. Additionally, Aβ-heme complex is a peroxidase and curcumin significantly inhibits the peroxidase activity of Aβ-heme [31]. The Tg2576 mouse model of AD exhibits impaired mitochondria metabolic activity in the spinal cord and curcumin partially suppressed the mitochondrial impairment reversing motor function deficits [32]. Interestingly, curcumin treatment abrogates lipid peroxidation protecting mitochondria from oxidative damage and apoptosis in cortical neurons [33]. Moreover, curcumin has been also shown in PC12 cells to provide protection against the deleterious effects of 4-HNE on mitochondrial redox metabolism, cytochrome c release, and DNA fragmentation [34]. The increased level of oxidative stress in AD is reflected by the increased brain content of iron (Fe2+) and copper (Cu2+) both capable of stimulating free radical formation. In addition to its properties of quencher, curcumin showed to be able to bind Cu2+ and Fe2+ ions [35]. Since these redox-active metals ions can intensify Aβ aggregation, curcumin may prevent this aspect of AD pathogenesis. Other reports suggested that curcumin regulates Fe2+ metabolism by modulation of Fe2+ regulatory proteins; therefore it may act as an iron chelator [36]. Significantly, in vivo studies reported that another divalent metal cation such as zinc (Zn2+) is highly enriched in Aβ plaques [37, 38] but its role in the amyloid landscape is still poorly understood and under investigation. However, even though curcumin more readily binds to the redox-active metals such as Cu2+ and Fe2+, it was also reported relatively weak affinity for the redox-inactive metal Zn2+ which might exert a small protective effect against Aβ by inducing metal chelation [35]. Recently, a systematic review highlighted the importance of inflammatory processes in the pathogenesis of AD [39]. AD secretes increasing levels of multiple inflammatory mediators, and considering the anti-inflammatory characteristic of curcumin, it was reported that this polyphenol reduced the level of interleukin-1β (IL-1β), a proinflammatory cytokine that appears elevated in the brains of AD-like mice [20]. Findings on the anti-inflammatory effects of curcumin were also provided by Jin et al. demonstrating that this natural phenol reduces the release of proinflammatory cytokines, such as IL-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) [40]. Indeed, curcumin abolished the proliferative effects of IL-6 because it inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) [41]. In a similar manner, curcumin downregulates the transcription factor activator protein 1 (AP1) through direct interaction with its DNA binding motif [42] and inducing the inhibition of IL-1α and TNF-α [43]. Several experimental lines suggest that the anti-inflammatory capacity of curcumin is associated to the reduction of the activity of nuclear transcription factors NF-kβ signaling pathway [44]. NF-kβ enhances the transcription of proinflammatory genes, such as inducible nitric oxide synthase (iNOS). In inflammatory cells, iNOS catalyzes the synthesis of NO, which can react with superoxide to form peroxynitrite which damages proteins and DNA. Curcumin has been found to inhibit NF-kβ-dependent gene transcription and the induction of iNOS in animal studies and macrophages cell culture [45, 46]. Probably, the inhibition of AP1 and NF-kβ occurs through the chromatin remodelling activity of curcumin that is able to modulate some histone deacetylases (HDAC) activity [47]. Moreover, curcumin attenuates the inflammatory responses through the inhibition of lipoxygenase and cyclooxygenase-2 (COX-2) enzymes, which are responsible of the synthesis of proinflammatory prostaglandins and leukotrienes [48]. Interestingly, the anti-inflammatory and neuroprotective effects of curcumin against dopamine induced neuronal death have also been demonstrated by Lee and coworkers which established that the inflammatory conditions induced by microglial activation are the main target for curcumin [49]. Noteworthy, curcumin exhibits protective effects on neuronal cells by inhibiting the aggregation of Aβ into oligomers and clearance effect on the exsting Aβ [50]. A very interesting in vivo approach with multiphoton microscopy showed the ability of curcumin to cross the blood-brain barrier (BBB) and disrupt amyloid plaques [51]. Additionally, in aged female rats with induced AD-like phenotype, curcumin prevented Aβ-induced spatial memory deficits in the Morris water maze assay, postsynaptic density loss, and reduced Aβ deposits [52]. As mentioned above, curcumin is able to clear amyloid plaques through several mechanisms and an additional activity that may be relevant is the induction of heat shock proteins (HSPs) molecular chaperones that are able to block protein aggregate formation [53]. However, even though several experimental research showed that curcumin exhibit high affinity binding to Aβ aggregates, one study reported the relationship between the tautomeric structures of curcumin, its derivatives, and their Aβ-binding activities. In particular, the results achieved by UV-visible spectroscopy revealed that the enolization is crucial for the binding and the enol forms of the curcumin derivatives are the predominant binding species for Aβ aggregates [54]. These important findings may represent a novel strategy for the design of therapeutic drugs or diagnostic tools in AD. Recently, Longvida, a curcumin formulation, has been evaluated in a Phase II Alzheimer's clinical trial (NCT01001637). Taking into account the low bioavailability of curcumin and its inability to reach required blood concentrations necessary to affect disease markers, Longvida is a solid lipid curcumin particle (SLCP) preparation and it was reported relatively higher bioavailability of SLCP compared to generic curcumin extract. Furthermore, this formulation is able to maintain plasma concentration of curcumin above the threshold required for the biological activity [55].
View Article: PubMed Central - PubMed
Affiliation: Clinical Biochemistry and Clinical Molecular Biology Laboratory, Department of Health Sciences, University of Molise, 86100 Campobasso, Italy.


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News Calendar
February 2019
Children of the stars?
First of June - children's Day. They all belong to this holiday in different ways, as to ways of protecting our loved children. Someone carefully selects the offspring of social circle, someone fills up the gifts and sweets, and some prefer to take heirs away and give them an education abroad
Back to school hairstyles on 1 September
On the eve of the Day of knowledge fashion stylist Anastasia Varganova specially for WomanHit
His daughter Anastasia Volochkova was первоклассницей
Yesterday in the life of a popular artist was a significant event: for the first time in school her six-year-old daughter Ariadna. Escort первоклашку went the whole family: Anastasia, her mother, Tamara Vladimirovna and the ex-spouse Igor Vdovin. On a school girl ruler had the honor to give the first call; in addition, Arisha for all participants read poems and sang the song
Mikhail Шуфутинский took granddaughter in the first class
The famous grandfather personally accompanied Anya on the Grand line. For the girl chose the school with profound studying of the Spanish language
Daughter Elena Sparrow looks to the West
The girl decided to take part in the American talent competition, jury member of which agreed to become an artist
How to help your child with homework?
Unfortunately, not all kids are quick to grasp stretch to study and happy to attain hitherto unknown to them Sciences. Let's try to understand what needs to be done so that the educational process your baby was not a burden, but delivered him and you joy


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As this is a Secondary School competition, we require the name and email address of the Principal/Dean or Art Teacher to confirm your entry. They will receive an email to reply to which will complete the entry process.
If more than one artist please designate one contact responsible for all correspondence with Play It Strange
At least one phone number must be provided.
1. The Creators (artists and idea developers) must be:
a) Resident in New Zealand or New Zealand citizens
b) At secondary school and be under 20 years of age
c) Attend school at least 16 hours a week.
2. The work must be original art. It must NOT be a copy or adaptation of a traditional non-copyright work.
3. Entries. The following will be required:
a) Completion of an official entry form
b) A jpeg, doc or pdf uploaded to the online form
a) and b) must be received by Play It Strange no later than Friday 26th of October 2018.
Send all postal entries to:
Play It Strange, Strange Art Competition, PO Box 137194, Parnell, Auckland
General Conditions:
a) Only ONE artwork may be submitted on an official entry form by or on behalf of any one creator and must comply with conditions 1 and 2.
b) We will be adding the following heading "2018 Lion Foundation Songwriting Competition" and the Play It Strange Logo and The Lion Foundation Logo.
c) All decisions of the judges will be binding on Play It Strange and the entrants.
d) In the event of more than one creator having collaborated in this competition winning work, the relevant prize will be allocated equally between the writers.
e) Play It Strange shall have the right to interpret the above conditions and to determine all issues arising out of this contest. Any such interpretations and determinations shall be final.
f) The winner grants permission for Play It Strange use of the artwork as Play It Strange sees fit.
in respect of the competition and all matter incidental thereto.
will be entered into.
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Form submission may take a few minutes while files upload. If you have problems please try again or contact us at email@example.com.
Alternately you can enter by downloading an entry form and sending it in.
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Book Tour and Activities on the Go!
Pick-Up & Drop
Trip Starting From: Wayanad
Trip Location: Wayanad
About the Activity:
With its lush-green tea – coffee estates on side and soaring peaks on the other side, Wayanad is a stunning district of Kerala. Located in the southern tip of Deccan Plateau, this place is a go-to destination for all people looking for an ample nature's dose.
Delight in this fascinating experience of camping in Wayanad located right in the heart of this place which enables you to explore nature till the brim. Located in the foot hills of the Chembra Peak at Vythiri in the Hill district of Wayanad, this 9 room facility provides you an experience of exclusive camping which is better from all other places that are crowding with tourists.
Enthral in a fascinating camping in Wayanad, rejoice while trekking to the neighboring Western Ghats. Delight in an amazing experience of trekking a waterfall with other group members. You can also take out some time and visit British Camp. Rejuvenate yourself while hearing distant chirpings of birds. Nature is your host here, enlighten with your friends and family while camping in Wayanad.
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Anti -Ragging Committee
Chairman : Dr. Johnson V. (Principal)
Nodal officer : Rev. Dr. Bennichen Scaria (Vice Principal)
Rev. Dr.James Punnaplackal (Bursar)
Mr. Saji K Jose (HOD, Dept. of Chemistry)
Rev. Dr. Jobi John (HOD,Dept of History
Mr. George Thomas (Jr. Supdt. in charge)
Mr. Thomas (Vice President, PTA)
Sub. Inspecter Murickassery
Village officer, Vathikudy Village
Mr. Noble Mathew (Youth Representative)
Mr. Gigi Baby (Media Representative)
Mr. Anoop Chandran (II B Sc Chemistry, Student Rep.)
Mr. Bibin Jacob (II B.Sc Physics, Student Rep.)
Sr. Tessy (Hostel Warden) 04868-260527
Anti Ragging Squad
Dr. Domini V. A. - Co-Ordinator
Dr. B Sindhu (Dept of Commerce)
Mr. Saji K Jose (HOD, Dept of Chemistry)
Mr. Saji Joseph (HOD, Dept of Physics)
Mr. Shajimon Scaria
Sr. Tessy(Hostel Warden)
Prevention of sexual harassment committee
Dr. Johnson V. - Principal and Chairman
Dr. Sindhu B. (Co ordinator)
Ms. Deepa Thomas
Ms. Alice Thomas
Adv. Joice George


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November 24, 2014 - Kim Moore [see other posts]
It was a short conversation
The young clergyman thanked me for the Fund's role in bringing information about insurance availability on the health insurance exchange to his community. I remembered that he had asked a lot of questions of the speaker at that session. I had presumed he was a critic of the Affordable Care Act looking for the problems. But that was not the case this time.
He explained that in his denomination (not United Methodist), local churches are not required to purchase health insurance for their pastors. For years, he, his wife and two children had not been able to secure affordable health insurance. They had worried that a medical issue -- a normal childhood accident, for example -- would cause them enormous financial problems. After hearing more about the health insurance exchange, he went online and was able to secure coverage for his family at an affordable price due to the group rating of products there and the subsidies. A load had been lifted from their lives.
He can't tell this story to his congregation because they are firmly against ObamaCare. I have tried to be careful in the telling so that somehow this example of appreciation for the ACA does not get back to them.
Nothing about this story, or its likely duplication into hundreds of thousands of American homes, will change the minds of people who oppose ObamaCare. To them, it appears that we are redistributing tax dollars through subsidies to people who can't afford coverage. It also points to millions of hard-working Americans who have been and continue to be living in the financial limbo of inadequate financial resources to pay for medical care they may need at any time. Of course, thousands experience the impossibility of payment and go into bankruptcy due to medical needs. Others slide by and delay preventive care, dental care, and medications needed for chronic illnesses.
Faced with a 30-percent plus increase in premiums for 2015, the Great Plains Conference of the United Methodist Church (Kansas and Nebraska) decided last month to terminate its group clergy health plan and give each clergy person $14,000 to go onto the health insurance exchange and purchase what they can. This contribution will be reduced by income taxes and self-employment taxes before being available to pay for insurance. Clergy will find lower group rates than they have experienced in the UMC Conference plan -- where the average age is mid-50s. Likewise, the costs of a small group of high users will not be integrated directly into their premiums but instead spread over a larger group of buyers. It is very likely that the flat amount of $14,000 will create a windfall for single clergy. Increased retirement contributions have to be paid on the taxable $14,000, so all clergy will get an increased retirement benefit. Although very little of the premium increase was due to the ACA (mostly due to higher than planned utilization) this is another example of the ACA at work and could be considered an example of how it creates incentives for some employers to drop their health plans. Now, clergy in my denomination will join the newly-insured clergy of other denominations which don't have clergy health plans, but our clergy are getting substantial help with the annual $14,000 payment. It will be interesting to see how this experiment goes for our Conference, with lots of uncertainties ahead (U.S. Supreme Court decision on health insurance exchange subsidies being the main one).
Health care costs are out of control. Health insurance premiums are too high (although growing less rapidly overall than prior to the ACA). See Kansas Health Institute report online or download the brief. The need for a financial source of payment for medical care gets ever more complicated. There are fewer and fewer short conversations on the subject.


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So - what do you think...did it turn out manly enough? Will you being joining our sketch and food challenge? Until next time...Keep scrapping!
Sunday, February 15, 2015
Birthday Cake Layout
So - what do you think...did it turn out manly enough? Will you being joining our sketch and food challenge? Until next time...Keep scrapping!
14 comments:
Love that black background! I must get me some of that paste! I've been meaning to for ages and just haven't. Love the way it looks! Great take on the sketch and that cake looks awesome!ReplyDelete
love te colors you choose abd how the layout turned out! blReplyDelete
Great take on the sketch and I'm lovin the black background.ReplyDelete
The black really makes it pop! Sharing to Twitter/Pinterest. I'm stopping by to give you some Bloggie Love! Thanks for your dedication to commenting on and sharing my work.ReplyDelete
La-Vie B.
Follow me at C'est La-Vie Designs Unlimited, LLC
Great LO! BLReplyDelete
I love black backgrounds! The green matches perfectly, and that cake looks delicious..... I just bought coloured modelling paste to cheat haha!ReplyDelete
What a fun layout! Great job on the sketch!! BLReplyDelete
Great manly layout. Love the green tracks and that you used the guitar paper too. A very personal page which I love.ReplyDelete
Big bold colors, great job. BLReplyDelete
Wow cool layoutReplyDelete
fun black background.. great page fun and bright colours.. BLReplyDelete
Love your layout! BLReplyDelete
fabulous layout. the black is really striking.ReplyDelete
The black background makes the other colors pop on your layout! Beautifully done!ReplyDelete
Your BL friend Tonya :-)


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Monthly Archives: July 2008
Custom Pockets
Local Custom
Seeing Orange
Confessions of a mother
I didn't think I'd be blogging about personal life on this blog since I do that on my other blog but I was having a rough evening with my children. The day started out fine enough, as they most often do. We all worked in the garden for quite a while since we haven't been able to do much picking veggies these last few weeks because the smoke here in Northern Calif. has just been SO bad. The kids are used to going outside and playing but for weeks now it's been hit and miss trying to get them out to run off their energy because of the days we've had of unhealthy air quality. The worst part is, there is NOWHERE to go. Yes, we could take them to a fast food place with a play area but who can do that everyday? It came to a point a couple weeks ago we just HAD to, we're almost to that point again.
Back to my day. I can already see the effects of their being cooped up now for almost 2 whole days and it's horrible, for everyone. They are jittery, chatty, full of energy and just full of innocent devilment and this evening I just got to the point where I couldn't take it. My husband is at school again this evening and normally him being gone isn't a big deal. Afterall, I'm used to being a military wife (which I am not anymore) but I'm used to being almost a single parent.
I couldn't take it a minute longer so I sent the kids to Great-Grandma with dinner for half an hour. All I need is half an hour to find my center, wherever it may be. I tried quietly eating dinner on the recliner but not before I took a few minutes to relax and breath. I wasn't feeling 100% normal again and I hopped on the computer, (of all places!) and went to my blog here and as soon as I heard the song "You're Gonna Miss This" by Trace Adkins and playing, it was like magic, I immediately felt better. I know that sounds corny, there are a lot of songs/music that I hold near and dear and I didn't hop on the blog to hear it. I hadn't even thought about it but it just came on like normal and just lifted a huge weight. It's amazing how songs and music can do that.
I know one day, I WILL miss this despite how frazzled I may have been only a moment ago. I already do miss things and I tell everyone how fast children grow and mine are only 4 and 2! So, I'm ready to have my children back again :o)-fresh new face, fresh new center.
And…if you can't hear the songs on the blog either A. turn your sound up if you're so inclined :o) or use Modzilla Firefox. Internet Explorer has been screwing things up lately.
I doubt these will be a regular thing. I drafted a pattern the other day and it didn't work so well for either way of sewing (serging or turning and topstitching- seee photo #2). I know there are some who like to serge the pads. It is much faster than T&Ting but I much prefer the look of T&Ting. I changed the wings on the pattern a little and it's working a lot better-see photo #1 & 3.
The second and third photo are pads that are of second quality. The stitching if off and far from perfect but they are priced right in the store! Especially nice if you're wanting to try them out without spending a ton of money. These things can get expensive.


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Pixel Pops™ Sticker Design Studios
The Orb Factory Limited
Age: 7 years and up
MSRP (USD): $9.99View on Manufacturer's Webpage
Like Sticky Mosaics for older kids. These self-sticking foam cubes are about twice as thick as the original Sticky Mosaic tiles, but with a base that covers only about a third of the area. In fact, they're quite small, and definitely require more fine motor control than the original sets. It helps that there's a very handy tool included, that fits around the cube, separating it from the others around it. But most of our testers still had difficulty. A small twist removes the cube from its backing paper, ready to stick on your creation-in-progress. The tool is also a big help positioning the cube exactly where it's supposed to go - so much easier than fingers getting in the way! Nevertheless, many testers had difficulty positioning the stickers, especially near the end of teh project when they ran out of roomm, and pieces needed to be suqished together to fit - causing an uneven picture surface.
I like the designs and I like that they are stickers that you can put anywhere. They stick really good. It's fun to make the pictures but it's really hard to get them straight and have enough room for every piece. You really have to take your time to place them just right or else there's no room to put the other pieces. I did a lot of them and put them all over my school agenda bag. They're really colourful.
The box says it is for 7 year olds. There is no way. I got really frustrated and was so upset doing it because it was hard and the individual pieces were hard to get out of the squares and put on that little needle. My picture also was not neat and that was upsetting. I think it would be too much to ask someone younger than me to do this type of art. I love art but this activity is too picky. I had a hard time taking the squares out of the sheet and putting them on the picture. I do not know how to handle the sheet of stickers well. I do not really like how the picture came out either. I did the dog first and it really does not look like a dog, but mom says it does. Not my favourite activity.
It's really fun and easy to do. I even made my own picture of Deadpool, he is so cool. It's a fun craft and now i have to find a good place to stick him.
My iPad is so pretty now and i made the sticker!
I don't like it. i can't line up the dots and my picture is crooked.
What a great little craft! I especially liked making my own patterns, I made a pixel pop that looked just like me!
Tammy W.
This is not an easy craft for f7 and f5. The stick used to pick up the pieces is quite small. The craft is not as easy as it looks and requires delicate placement of the pieces. It was somewhat frustrating for the girls to place the stickers properly. It seems when they were near the end of the sticker design, they ran out of room for the final few pieces and had to squeeze them in between the others which left parts of the finished product raised. This wasn't a favourite craft but it was still intriguing. The final products stick very well onto different material. They chose to stick the final product onto their school agendas. They have yet to try to copy the picture design onto a sticker or make their own design but I think that may prove to be quite difficult considering the templated stickers were trying. It seems the best way to pick up the pieces is by pushing straight down on them with the stick and sliding them to the side and up instead of just lifting them straight up. It's a neat variation of the sticky mosaics and the girls enjoy the craft. I like the ziploc bag to keep the pieces together.
Orietta M.
Not a good toy for my daughter and she is very creative. She wanted to do it right away but then was upset because it provided her more grief then it was worth. She did complete some of the pictures that were provided in the kit but the sticky squares really were difficult to take out with that small device and she threw a bunch out because they got all sticky together. The pictures were not the quality she was hoping for and she really scrutized how the picture looked. She was not impressed with the final copy. She did stick the squares she completed to her binders from school.
Marie Lise H.
Mia (12) tends to not have a lot of patience, she had no trouble with this craft. She found that by removing the outer square it was easy to pick up the smaller squares inside followed the coloured example for her first square and then made her own picutre after. The tool worked fine. Kai(11) started his design before going to bed and just could not stop until he finish a Deadpool face. There are a lot of supplies included, it surprised me how much fun they had out of such a simple idea.
Manufacturer Description
Create Pixeleated pictures to decorate your phone, books, and more! Use the templates or create your own unique styles.
Model Number
# 71417
Year Introduced
2 styluses


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Archives for December, 2016
Of three workers and a desert(3)
Friday, December 23rd, 2016
– What the fuck?!Who done this? Joseph, Woyzeck, who did this?! – Wouh, wouh, take it down a notch, that spirit was hard, Zi…shit, with apologies to language masters and elders, you got a black eye in your your drunken mug, Zigmund! – I know, Woyzeck, woke up my face to the pole and this […]


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Dubrovnik is definitely worth visiting for reasons that are difficult to describe in words as much as with a photo, however talented you may be. Why? Simply because words and photos cannot communicate what matters about this town, the first encounter with it and the elation you feel when you see it for the first time… Approaching the town from the north, from Pile, with the breathtaking view of the town walls opening up before you, will leave no one indifferent. This love at first sight is what makes this town one of the world's most popular tourist destinations. Its walls soar up from the blue of the Adriatic Sea and blend with their surroundings seamlessly, unobtrusively, naturally, like the ridges that have stood sentinel over Dubrovnik's beaches for millions of years.
Until 1808 Dubrovnik had been a city-state, a frequently occurring phenomenon in the Mediterranean at the time, famous for its skilled diplomats and seamen. Its good standing with the Ottoman Empire and the role of the trade mediator between the East and the West helped Dubrovnik accumulate tremendous wealth. In the 15th and 16th centuries Dubrovnik's ships traded all over Europe and sailed the Atlantic and the Indian Ocean, too. The fact that the investment in a new ship was fully returned after only two voyages tells us much about how profitable trade had been at the time.
In the modern times tourism took precedence over trade. Dubrovnik's breathtaking old town centre was included in UNESCO's cultural heritage list back in 1979, when Dubrovnik became one of the first towns in the world to enjoy such protection.
The walls that enclose Dubrovnik from all sides, 2 kilometers long, 25 meters high and 6 meters wide in places, are one of the biggest and best preserved city walls in Europe, having made Dubrovnik unconquerable for as long as 500 years.
Two fortresses outside of the city walls, Revelin and Lovrijenac, are protecting Dubrovnik's east and west gate. Lovrijenac is built on a 30-metre cliff north of the town, in a strategically important defense position. It used to house Mediterranean's largest cannon, which never fired a single shot, but was very effective in scaring away potential conquerors. The design of the fortress is very interesting. The seaside walls are 12 meters thick, whereas the walls that face the town are only 60 centimeters thick, making it easier to breach the walls if the fortress falls into enemy hands. A Latin motto so typical of Dubrovnik is written at the fortress' entrance: "Freedom is not sold, not even for all the treasures of this world" (NON BENE TOTO LIBERTAS VENDITUR AURO). During the Dubrovnik Summer Festival both fortresses become the venues of theatre plays. If you are lucky enough to find tickets, you can see Hamlet on this truly extraordinary stage.
Dubrovnik's broadest street, the Stradun, starts at the town gate, passes through the town centre and ends exactly at the Duke's Palace, the site of classical music concerts at the time of the festival. Spectacular New Year's Eve parties are organized here every year, when the holiday decorations give the medieval town a special glamour.
Mount Srđ, on whose steep slopes this pearl of the Mediterranean nests, offers the most amazing panoramic view of Dubrovnik. A cableway whose starting point is located right next to the city walls will take you there in the blink of an eye. The view from the top of the mountain is amazing: you can see every street, every roof, the barges rocking on the waves next to the walls, and the little boats hurrying toward the nearby islands.
If you happen to come across the Little Brothers Church facing Stradun, look for an owl-shaped stone protruding from the wall, which often attracts groups of tourists. The legend has it that anyone who manages to put both feet on it and remain in the position long enough to change their shirt is bound to fall happily in love soon. Generations of town residents and guests have been trying it, some successfully, others less so, but the owl head still helps everyone who comes to Dubrovnik stay forever in love with this amazing town.
If you are planning to visit Dubrovnik, You don't have to worry about accommodation. Dubrovnik offers plenty of quality hotels and apartments. For more information about private accommodation in Dubrovnik, check this link:


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This has been tremendously frustrating for me since the beginning. BnS has an insane amount of incredible costumes. And one of BnS's major selling points is cosmetics. Having 4+ years worth of costume content given to us in (very) tiny little spurts every two weeks or so is upsetting. There should be more costumes added to the rotation and to the store itself.
This business tactic actually has the opposite effect on me. There are a plenty of costumes that I'm looking forward to. And at this rate, who knows when we will get them. Could be months, or over a year??? Since release, we've only gotten 2 of them….
One costume in particular is from the very beginning of the game, and we still don't have it yet!
The rotations have left me disappointed most of the time. And it's only 2 costumes. 2 weeks is a long time to wait for 2 costumes…out of 100+. And that 2 weeks can easily become months before they release something you really like to Buy BNS Gold. So instead of comfortably spending money on extra costumes, I keep saving and saving and saving for when they release the costumes I want the most.
If I knew there were more coming each time, I would feel more comfortable spending on more costumes because I have more options. More costumes = wider range of tastes as well.
For example: One rotation they put out that basic suit/maid costume and an ugly toga-looking thing. We all know that rotation was meant for the people who want to run around in a maid costume. So what about people who wanted a cool or elegant costume? There are tons! So all those people have to now wait 4 weeks in hopes for a cool costume….only to be given a hoodie (or another modern type clothing item)! And now they have to wait 6 weeks. This is the type of situation that results from this, and this is why people feel like they're holding back so much from us.
There definitely need to be both. Rotations are good, as long as enough people like what's in the rotation enough to care if the costumes come back or not. But 2 costumes definitely is way too few. More costumes added to the rotations + a major store update every couple months would be perfect. Otherwise how will we EVER get anywhere close to catching up? By the time we get all the costumes up to 2.0, there will be another hundred new costumes made.
After about 4 months since release, they added 3 new costumes to the store. I wouldn't call that a major update considering how many costumes we've never even seen yet lol
And the rotation is still the same; 2 costumes.
– See more at: http://www.blade-soul.com/news/bns-has-an-insane-amount-of-incredible-costumes#sthash.JFudbphT.dpuf


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|تعداد نشریات
|تعداد شمارهها
|تعداد مقالات
|تعداد مشاهده مقاله
|تعداد دریافت فایل اصل مقاله
Microstructure and Swelling Behaviour of Poly (Acrylamide-co-Acrylic Acid) based Nanocomposite Superabsorbent Hydrogels
|Journal of Nanoanalysis
|مقالات آماده انتشار، پذیرفته شده ، انتشار آنلاین از تاریخ 22 تیر 1397
|نوع مقاله: Original Research Paper
|شناسه دیجیتال (DOI): 10.22034/jna.2018.560280.1071
|Ahmad Gholizadeh 1؛ Sasan Ganjehie2؛ S. Ahmad Ketabi2
|1School of Physics, Damghan University (DU), Damghan, Islamic Republic of Iran
|2School of Physics, Damghan University (DU), Damghan, I.R., Iran
|In this paper, microstructure and swelling behavior of five superabsorbent hydrogels have been investigated. These samples were prepared by dispersing watermelon shell powder (WSP) and cucumber shell powder (CSP), mixture bentonite and WSP, mixture bentonite and CSP, zeolite (Z) bentonite (B), into poly(acrylamide-co-acrylic acid) (P) backbone in an aqueous medium. The nanocomposites have been synthesized through chemical cross-linking by polymerization technique using N,N-methylenebis acrylamide as a cross-linker and potassium persulfate as an initiator in a simple aqueous environmental conditions. The nanocomposite hydrogels named as P-WSP-CSP، P-WSP-B، P-CSP-B، P-Z، P-B, respectively. These superabsorbent nanocomposites were characterized by X-ray diffraction, Fourier transform infrared and field emission-scanning electron microscope measurements. The water absorption and desorption of the superabsorbent nanocomposites have also been studied. Our findings show that very high water absorption and lower drying rate of P-CSP-B are attributed to higher porous surfaces observed in FE-SEM images. The results show the superabsorbent hydrogels based on CSP represent very high water absorbency capacity and water retention ability that make them suitable for technology applications.
|Superabsorbent؛ Nanocomposite؛ chemical cross-linking method؛ Structural and surface properties؛ Water absorption and retention
تعداد مشاهده مقاله: 84


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Kaminski, Robert
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