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After a string of flops, the lovely, accomplished and under-appreciated Natalie Portman achieved something of a career breakthrough in the pretentious horror flick Black Swan. Now, before the impact has worn off, and on the verge of an Oscar nomination, she crumbles like a mildewed crumpet. Short of breaking into the editing lab and destroying the negative, she should have done everything legally possible to stop the ill-timed release of a vulgar, stupid pile of junk called No Strings Attached. This movie could destroy everything.
Who deserves the blame for this worthless and unforgivable bore? Probably Ivan Reitman, the Canadian hack who lowered the bar for brain-dead comedy by directing trash such as Meatballs, Kindergarten Cop and Cannibal Girls. He also produced such historic film classics as Trailer Park Boys, Hotel for Dogs, the Howard Stern horror Private Parts, and the abominable Animal House. Do not confuse him with Jason Reitman, who made the refreshing Up in the Air. That's the son. So much for placing your future, at a crucial turning point in your career, in the hands of a pro. But wait. Portman is herself part of the blame. Nobody with an upwardly mobile career who is suddenly being taken seriously would co-star in a movie with Ashton Kutcher. She also executive-produced this mess. You can't trust anybody.
No Strings Attached peddles the preposterous idea that two people terrified of committed relationships can have a perfectly normal, happy and fulfilled life as "sex buddies." Emma (Portman) is a med-school student. Adam (Kutcher) is a struggling writer working as a glorified go-for on a noisy cookie-cutter TV ripoff of Glee. They met cute, 15 years earlier, on a one-night stand at summer camp, then hooked up again at a drunken college pajama party. By the time their paths cross at a food festival—in a movie that knocks itself unconscious trying to think up kooky reasons and places to have sex—he wakes up naked and hung over in the apartment she shares with two girls and a gay roommate who insists he's got menstrual pains.
No wonder they're afraid of intimacy. Everyone around them is a sex-crazed lunatic auditioning for a psychotherapist. Even Emma's mother, pointing to the creep snoring in the back seat, says "He's a remarkable lover." (Pause). "That's why they call him Bones." Meanwhile, Adam is stuck with a moronic father (Kevin Kline) who is a faded TV star, now shacked up with his own son's bimbo girlfriend and festering in a hospital bed after an overdose of vodka, 7-Up and purple cough syrup. Kline once starred in Reitman's vastly superior film Dave, so this must be the director's way of paying him back. At one point, he dances and prances his way through a birthday party singing "I'm so happy…to be your pappy!" The criminal waste of a first-rate talent in 10th-rate material is so embarrassing you want to recommend a good prosecuting attorney.
The two stars use each other for sex at all hours of the day and night with no strings attached and—God forbid!—no love. Also no fighting, lying, jealousy, gazing into each other's eyes or speaking words with more than two syllables. He brings her a special soup that is good for her uterus.
When things get intense, she insists he has sex with total strangers, but the girls he settles on for a threesome fall in love with each other.
The big twister: The farther they get from romance, the closer they get to craving each other 24/7. Duh. A five-minute plot stretches over two hours of tedium that gives you a royal pain in the sacroiliac. The stars have zero charisma. Sexy and petite, Portman outclasses her co-star in ways you can't even remember. Clumsy and superficial, Kutcher is mired in the kind of clueless, adolescent smirking that typified his obnoxious TV "punking." He can't act, so when in doubt, he clutches a towel to his johnson and bears his bubble butt to keep the teenage girls shrieking. It's two hours of "Call me," "Don't call me," "Should I call him?" "He doesn't want me to call him." It's a chore trying to describe the paralyzing tedium. It's also totally beneath Portman, and Reitman is no help, failing miserably to get under the skin of synthetic characters who are pure plastic, and drowning one-dimensional cardboard clichés in sitcom-ready caricatures.
The moronic screenplay, by Elizabeth Meriwether, forces Portman to prattle endlessly about condoms, premature ejaculations, menstruation and leaving the door open when she pees. The writer is quoted in the production notes confessing: "The film is a sort of wish fulfillment for me." She must be the kind of girl who leaves the toilet seat down.


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34th Iowa Infantry Detachment
Iron tablet located at Navy Circle on South Washington Street. A detail of the 34th Iowa under the command of Acting Master J. Frank Reed of the gunboat Benton served two 42-pdr. rifled guns in "Battery Benton" from the morning of 1 July 1863 until the end of the siege. A shell from the Confederate mortar in South Fort exploded in the battery on 1 July 1863 killing 1 & badly wounding 4 enlisted men of the 34th Iowa Infantry detail.
Last updated: April 14, 2015

subset: commoncrawl


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Nevertheless, it will not mean that there aren't addictive, some enjoyable and best of all Android games that are free. In the end, we are speaking about an open source platform backed by Google. Android gaming is rapidly growing and among the a large number of games it's getting more difficult to keep track of the quality ones.
Be honest: we reside in a guy 's world, in regards to gaming. Even the Google Play shop (the content shop for the Android OS devices) is filled with games targeted at guys.
So imagine if you're a woman who enjoys gaming and really wants to then add interesting games to her Android device? Well, the good thing is that there are really a lot of alternatives out there- female-targeted RPGs, fashion games, fun time management games, and more.
Ok, enough with the "create an avatar and be a celeb" games- here's something a bit different.
Simcity Buildit is a video game where the primary focus would be to grow the city that is best possible. You get a piece to put on the tree section of grass board, either a bush,, or, and you have to figure out a location on the map to position it. Then you match three of the same (bush, grass, tree) to create other things: houses, cathedrals, castles.
Believe, simcity buildit apk mod is an interesting application, although it's a bit confusing on paper. Since you must spend some time deciding where the very best location is to determine which things to unite to develop your town, and then to lay out each item you're given it's a strategy game that is good too. It takes some real strategic moves to snare bears and area churches where you need them to be (and should you trap a bear alone, it'll become an unmovable tombstone, which can be essentially merely a waste of space in your town, and that means you will want to think sensibly).
Do you regularly play hack simcity buildit game via your mobile phone during your daily commute to work? Would you play online games with friends? Do you want to learn all you can about video games? The artwork may be worth noting as well - element of the fun is watching the people walk about and speak in their own little language and bears the little town, and folks are simply adorable. Simcity Buildit is a fantastic game and also you can love more to use simcity buildit cheat.


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Happy Independence Day! I am so glad that I was lucky enough to be born in this country. Thank you to all those who have served us to keep us safe.
What the girls said this week
Zelda: "I gotch-you! I so funny."
We were listening in the car to "Let it Be" by the Beatles. Ellie heard it, and said: "Let it be? What?! It's Let it Go!"
What we did this week
Okay, this is actually something from a couple weeks ago. In Jason's PA class they had to make videos a while ago explaining the necessity of doing a certain procedure and demonstrating how to do it. Jason's video was really good and really funny. A couple weeks ago they held a mini-Oscars in their class and watched all the videos, and Jason's won "Best Picture." :)
I think Ellie just had a growth spurt; she looks a couple inches taller to me than before. She's continuing to learn and grow; she's getting really good at reading short words. She also loves imaginative play; one of her favorites is to have "creature powers" (from the show Wild Kratts) and run around the house saving imaginary people and animals.
|Something Ellie did.
Zelda loves dress up. She'll bring us clothes from the dress up bag all the time, wanting us to help her put them on. And other times she'll be walking around, having dressed herself up:
Zelda also loves baby dolls. They're one of her favorite toys to play with, and she'll carry them all around and take care of them. This one she "decorated" very carefully with stickers this week:
Something super cute Zelda's started to say is "I gotch-you!" She'll run toward us and grab out legs and then yell, "I gotch-you!" She also likes to run around in circles or run down the hall and then tell us, "I so fast! I so fast!"
I've been reading more about Spain and Portugal this week. We leave in three weeks! That's just crazy. I am sooo excited. I even pulled the suitcase down out of the attic this week to start packing some things. Squee!
So, on to things the whole family did this week:
Ellie, Zelda, and I all got multiple chigger bites. I have decided that I hate chiggers. They're my new least favorite insect.
We got a shade canopy for the back deck. We've been talking about it for a little while, because the girls love to play out there but the wood gets so hot in the middle of the day with the summer sun. Jason went to Walmart after classes one day this week, and brought home a shade canopy. It's great! Here's the girls having a picnic under it the first day we got it.
Then we went hiking at Raven Rock State Park yesterday, and it was sooo fun. Jason had the day off of school, so we took the girls out pretty early (I think we got there at about 8:30 or 9) and did the two mile loop trail out to Raven Rock.
The girls had a blast. They were so excited that they were running down the trail when we first got there. The forest was absolutely gorgeous, and it was a perfect temperature for walking.
Close to the start of our walk, Ellie pointed at a sign next to a tree along that pathway (that said something like, "Welcome to Raven Rock State Park." Ellie: "Look what it says! It says it's a perfect tree for birds."
We walked down a cool staircase to get down to the rock. It reminded me of the Swiss Family Robinson or Tom Sawyer's Island at Disneyland.
|The girls found some earthworms coming out of the ground.
While we were down exploring by the rock it started to rain. And not just a little. A lot. It was pouring. And we knew from having looked at the weather report that morning that once it started to rain, it was going to rain all day. So, there was no point in trying to wait it out before walking back the mile and a half to the car. Luckily, it was a warm rain, but we were all going to look like we jumped in a swimming pool.
This is what walking back looked like at first:
Soon Zelda let me take her, though, and Ellie discovered that she could splash in all the puddles forming a long the trail. She loved that, and that kept her occupied for about a half mile until we reached the overlook.
Jason carried Ellie the rest of the way to the car and I carried Zelda.
It was such a fun outing and Jason and I were both really glad we did it.
Later yesterday, we went to the Fuquay 4th of July celebration (yes, they had it on the 3rd). It was held in a big park in Fuquay and they had all sorts of inflatable bounce houses and obstacle courses for the kids. Ellie did three different bounce house things, and then Ellie and Zelda both rode in this fish ride (which they loved).
They closed down all the rides at 9 o'clock so that they could do fireworks at 9:15. We were wondering how Zelda would do with the fireworks this year since she doesn't like loud noises, but she did great! Both girls really enjoyed the firework show.
We think we're going to take today easy and stay at home, since Jason and I are both kind of exhausted from yesterday. We have some neighbors down the street that we think will do fireworks, so we might walk the girls down there to watch.
Happy 4th of July!!


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You are viewing an Email identified as a Scam, It has the Subject "CONTACT PARCEL EXPRESS COURIER COMPANY" and it was received in one of Scamdex's honeypot email accounts on Tue, 07 Apr 2009 23:34:50 -0700 and has been classified as a Generic Scam. The sender was email@example.com, Gad Amatu <>, although that address was probably spoofed. It is recommended that you do not attempt to contact any persons or organizations referenced in this email, as you will expose yourself to scammers and, at the very least, you will be added to their email address lists for spam purposes.
Dear Friend, Good Day, I have waited for your Email as you promised but did not hear from you. So i went to the Bank of Africa to confirm if the Cheque is getting close to expire and the Manager of the bank told me that before the draft will get to your address that it will expire. Then I told him to help me and cash the bank draft of $2.5 million to cash payment. However, I have successfully cashed the Cheque and packaged your Cash in a Cargo box and had registered it in the PARCEL EXPRESS COURIER COMPANY here in Benin Republic because I will travel soon to see my boss and will not come back soon. You have to contact the PARCEL EXPRESS COURIER COMPANY to know when they will deliver your package to your address. I have paid for the delivering charges and insurance fees. The only money you have to send to them is their SECURITY KEEPING FEE to receive your package and as i do not know when you will be contacting them. HERE IS PARCEL EXPRESS COURIER COMPANY ADDRESS BELOW/ DR ARNOLD AKA E-MAIL: ( email@example.com ) CONTACT PHONE (+229)98232691 Please, Send them your contacts information to able them locate you immediately they arrived in your country with your BOX. This is the information they need from you. 1. YOUR FULL NAME. 2. YOUR HOME ADDRESS. 3. YOUR CURRENT MOBILE NUMBER. 4. YOUR OCCUPATION 5.YOUR PHOTOGRAPH Try to contact PARCEL EXPRESS COURIER COMPANY as soon as possible to avoid increasing the security keeping fees. I gave them your delivering address but you have to reconfirm it to them again to avoid any mistake in the delivery. Note; I didn't tell the PARCEL EXPRESS COURIER COMPANY that it's money inside the box, I registered it as a package of an African cloths/Family Valuables. This is to avoid delaying or any upfront problem during the delivery, So do not let them to know that the package contents money inside until you have received it in your house address ok and this is the code which you send to them for verifications (PX008). Do let me know as soon as you received your package. My Regards to your Family. Yours, Mr,Gad Amatu


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Goathead Software needed a new logo design and created a contest on 99designs.
A winner was selected from 76 designs submitted by 26 freelance designers.
Goathead Software LLC
We are new software startup. Most people name their companies after oak trees, mountains, or eagles we enjoy the lowly (but cunningly designed) goathead sticker.
It is mostly for us. Something to put on a ballcap or shirt. Maybe a business card.
We need just a logo. Clear. Efficient. Perhaps just the goathead sticker and "Goathead Software".
You can google the goathead sticker to get an idea of what they look like. We picture in our minds the tawny colored sticker. Would a maroon or navy color go well with that?
Please do not use clip art or stock images. Our money will be paid for full ownership, copyright, and use of the images. Please supply the winning images in a Gimp or Photoshop format.
Find out how a design contest works or learn more about our logo design services.


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Sales Director UK
Orange Business Services - Trading Solutions
Responsible for the leadership, management, coaching and training of the sales organisation
Achieved all revenue growth, sales orders and profit targets for the period 2008 to 2009.
Won several large Managed Services contracts to BNP Paribar, ICap, Louis Capital, Soc.Gen, GFI & UBS.
Sales leadership of the 1st Low Latency Managed Network contract for Orange Business Services in the UK sold to GFI worth £60,000.
Sales leadership of a large Voice Recording Managed Services contract sold to Zurich Financial worth £800,000.
Sales leadership of a large Voice Recording Managed Services contract sold to UBS worth £750,000
Sales leadership of 'Unified Communications' software solution to Total Gas worth £115,000.
Refocused the sales team to win more new business in existing and new accounts. This objective was achieved by using a 'Value Selling' methodology and focused tactical campaign management.
Leadership and delivery of a 'Sales Transformation Programme' introducing the 'Value Selling' Methodology and Salesforce.com CRM system into company.
Introduced and opened up new routes to market for Trading Room Solutions through the System Integrators and Contact Centres channels.


text:
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text:
- Description
Letters of Intent due
- Website
- Competition Organizer
Thompson Rivers University in Kamloops, British Columbia
- Submission Date
- Business Plan Submission Date
- Awards Date
- Total Prize Cash (US Dollars)
- Competition Category
- Undergraduate - Global
- Graduate - Canada
- Who's Eligible
- All official entrants must be attending school on either a full or part-time basis.
- Important Dates
Letters of Intent must be submitted by February 1, 2011. Full business plans are due by February 18, 2011. The top 5 entrants will be notified by March 11, 2011, and will present their business plans on March 26, 2011.
- Competition Prizes
1st prize: $7,500 CDN
2nd prize: $2,500 CDN
- Other Info
The Tony Brewer Innovation Exposition now includes a JR. competition, which is open to all senior high school students in British Columbia and offers a $500 scholarship as the prize.


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Home > Perspective Mesh Back Guest Chair
NBF Signature Series
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(1-5) $169; (6-10) $159; (11-15) $149; (16+) $139
The Perspective mesh back guest chair is a comfortable guest seating option that won't look out of place in your office. Designed to complement other chairs in the Perspective collection, you can coordinate your office space with a matching office chair, stool, guest chair or nesting chair.
Designed with a four leg base and a comfortable, cool mesh back, this chair won't get as stuffy as overbearing leather chair, and is especially nice for warmer offices. The memory foam seat is particularly appreciated during those long waiting periods, or extended cubicle discussions with a coworker.
Assembly required.
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Frequent Links
Open Access Articles- Top Results for Vascular endothelial growth factor
Angiology: Open AccessPredictive Value of Circulating Vascular Endothelial Growth Factor-1 Level Measured Repeatedly During Long-Term Follow-Up in Patients with Arterial
Journal of Clinical & Experimental OphthalmologyTreat and Extend Versus Treat and Observe Regimens in Wet Age-related Macular Degeneration Patients Treated with Ranibizumab: 3-year Surveillance Peri
International Journal of Genomic MedicineNRP1 Activates NF-κB Signaling Pathway and Initiates Proliferation in Keratinocytes
Journal of Thyroid Disorders & TherapyPro and Anti-Angiogenic Vascular Endothelial Growth Factors Expression in Benign and Malignant Thyroid Lesions
Journal of Homeopathy & Ayurvedic MedicineProspective Role of Indian Medicinal Plants in Inhibiting Vascular Endothelial Growth Factor (VEGF) mediated Pathological Angiogenesis
Vascular endothelial growth factor
Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF),[1] is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate. Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus.[2] VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.
When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. Drugs such as bevacizumab and ranibizumab can inhibit VEGF and control or slow those diseases.
VEGF is a sub-family of growth factors, to be specific, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature).
VEGF was first identified in guinea pigs, hamsters, and mice by Senger et al. in 1983.[1] It was purified and cloned by Ferrara and Henzel in 1989.[3] VEGF alternative splicing was discovered by Tischer et al. in 1991.[4] Between 1996 and 1997, Christinger and De Vos obtained the crystal structure of VEGF, first at 2.5 Å resolution and later at 1.9 Å.[5][6][7]
Fms-like tyrosine kinase-1 (flt-1) was shown to be a VEGF receptor by Ferrara et al. in 1992.[8] The kinase insert domain receptor (KDR) was shown to be a VEGF receptor by Terman et al. in 1992 as well.[9] In 1998, neuropilin 1 and neuropilin 2 were shown to act as VEGF receptors.[10]
The VEGF family comprises in mammals five members: VEGF-A, placenta growth factor (PGF), VEGF-B, VEGF-C and VEGF-D. The latter ones were discovered later than VEGF-A, and, before their discovery, VEGF-A was called just VEGF. A number of VEGF-related proteins encoded by viruses (VEGF-E) and in the venom of some snakes (VEGF-F) have also been discovered.
|Embryonic angiogenesis (myocardial tissue, to be specific)[11]
|Needed for the development of lymphatic vasculature surrounding lung bronchioles
|Important for Vasculogenesis, Also needed for angiogenesis during ischemia, inflammation, wound healing, and cancer.
Activity of VEGF-A, as its name implies, has been studied mostly on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g., stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells). In vitro, VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor.
There are multiple isoforms of VEGF-A that result from alternative splicing of mRNA from a single, 8-exon VEGFA gene. These are classified into two groups which are referred to according to their terminal exon (exon 8) splice site: the proximal splice site (denoted VEGFxxx) or distal splice site (VEGFxxxb). In addition, alternate splicing of exon 6 and 7 alters their heparin-binding affinity and amino acid number (in humans: VEGF121, VEGF121b, VEGF145, VEGF165, VEGF165b, VEGF189, VEGF206; the rodent orthologs of these proteins contain one fewer amino acids). These domains have important functional consequences for the VEGF splice variants, as the terminal (exon 8) splice site determines whether the proteins are pro-angiogenic (proximal splice site, expressed during angiogenesis) or anti-angiogenic (distal splice site, expressed in normal tissues). In addition, inclusion or exclusion of exons 6 and 7 mediate interactions with heparan sulfate proteoglycans (HSPGs) and neuropilin co-receptors on the cell surface, enhancing their ability to bind and activate the VEGF receptors (VEGFRs).[12] Recently, VEGF-C has been shown to be an important inducer of neurogenesis in the murine subventricular zone, without exerting angiogenic effects.[13]
All members of the VEGF family stimulate cellular responses by binding to tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation, although to different sites, times, and extents. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region, and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1).[15] VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well-defined, although it is thought to modulate VEGFR-2 signaling.[16] Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). VEGF-C and VEGF-D, but not VEGF-A, are ligands for a third receptor (VEGFR-3/Flt4), which mediates lymphangiogenesis. The receptor (VEGFR3) is the site of binding of main ligands (VEGFC and VEGFD), which mediates perpetual action and function of ligands on target cells. Vascular endothelial growth factor-C can stimulate lymphangiogenesis (via VEGFR3) and angiogenesis via VEGFR2. Vascular endothelial growth factor-R3 has been detected in lymphatic endothelial cells in CL of many species, cattle, buffalo and primate.[17]
VEGF-A production can be induced in cells that are not receiving enough oxygen.[15] When a cell is deficient in oxygen, it produces HIF, hypoxia-inducible factor, a transcription factor. HIF stimulates the release of VEGF-A, among other functions (including modulation of erythropoiesis). Circulating VEGF-A then binds to VEGF Receptors on endothelial cells, triggering a Tyrosine Kinase Pathway leading to angiogenesis. The expression of angiopoietin-2 in the absence of VEGF leads to endothelial cell death and vascular regression.[18] Conversely, a German study done in vivo found that VEGF concentrations actually decreased after a 25% reduction in oxygen intake for 30 minutes.[19] HIF1 alpha and HIF1 beta are constantly being produced but HIF1 alpha is highly O2 labile, so, in aerobic conditions, it is degraded. When the cell becomes hypoxic, HIF1 alpha persists and the HIF1alpha/beta complex stimulates VEGF release.
Clinical significance
VEGF in disease
VEGF-A has been implicated with poor prognosis in breast cancer. Numerous studies show a decreased overall survival and disease-free survival in those tumors overexpressing VEGF. The overexpression of VEGF-A may be an early step in the process of metastasis, a step that is involved in the "angiogenic" switch. Although VEGF-A has been correlated with poor survival, its exact mechanism of action in the progression of tumors remains unclear.
VEGF-A is also released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and swelling and also stimulating angiogenesis (formation of capillaries).
VEGF-A is also important in diabetic retinopathy (DR). The microcirculatory problems in the retina of people with diabetes can cause retinal ischaemia, which results in the release of VEGF-A, and a switch in the balance of pro-angiogenic VEGFxxx isoforms over the normally expressed VEGFxxxb isoforms. VEGFxxx may then cause the creation of new blood vessels in the retina and elsewhere in the eye, heralding changes that may threaten the sight.
VEGF-A plays a role in the disease pathology of the wet form age-related macular degeneration (AMD), which is the leading cause of blindness for the elderly of the industrialized world. The vascular pathology of AMD shares certain similarities with diabetic retinopathy, although the cause of disease and the typical source of neovascularization differs between the two diseases.
VEGF-D serum levels are significantly elevated in patients with angiosarcoma.[20]
Once released, VEGF-A may elicit several responses. It may cause a cell to survive, move, or further differentiate. Hence, VEGF is a potential target for the treatment of cancer. The first anti-VEGF drug, a monoclonal antibody named bevacizumab, was approved in 2004. Approximately 10-15% of patients benefit from bevacizumab therapy; however, biomarkers for bevacizumab efficacy are not yet known.
Current studies show that VEGFs are not the only promoters of angiogenesis. In particular, FGF2 and HGF are potent angiogenic factors.
Patients suffering from pulmonary emphysema have been found to have decreased levels of VEGF in the pulmonary arteries.
In the kidney, increased expression of VEGF-A in glomeruli directly causes the glomerular hypertrophy that is associated with proteinuria.[21]
VEGF alterations can be predictive of early-onset pre-eclampsia.[22]
Anti-VEGF therapies
Anti-VEGF therapies are important in the treatment of certain cancers and in age-related macular degeneration. They can involve monoclonal antibodies such as bevacizumab (Avastin), antibody derivatives such as ranibizumab (Lucentis), or orally-available small molecules that inhibit the tyrosine kinases stimulated by VEGF: lapatinib (Tykerb/Tyverb), sunitinib (Sutent), sorafenib (Nexavar), axitinib, and pazopanib. (Some of these therapies target VEGF receptors rather than the VEGFs.) THC and cannabidiol both inhibit VEGF and slow Glioma growth.[citation needed]
Both antibody-based compounds are commercialized. The first three orally available compounds are commercialized, as well. The latter two (axitinib and pazopanib) are in clinical trials.
Bergers and Hanahan concluded in 2008 that anti-VEGF drugs can show therapeutic efficacy in mouse models of cancer and in an increasing number of human cancers. But, "the benefits are at best transitory and are followed by a restoration of tumour growth and progression."[23]
Later studies into the consequences of VEGF inhibitor use have shown that, although they can reduce the growth of primary tumours, VEGF inhibitors can concomitantly promote invasiveness and metastasis of tumours.[24][25]
AZ2171 (cediranib), a multi-targeted tyrosine kinase inhibitor has been shown to have anti-edema effects by reducing the permeability and aiding in vascular normalization.
A 2014 Cochrane Systematic Review studied the effectiveness of ranibizumab and pegaptanib, on patients suffering from macular edema caused by central retinal vein occlusion.[26] Participants on both treatment groups showed improvement in visual acuity measures and a reduction in macular edema symptoms over six months.[26]
VEGF is also inhibited by thiazolidinediones (used for diabetes mellitus type 2 and related disease), and this effect on granulosa cells gives the potential of thiazolidinediones to be used in ovarian hyperstimulation syndrome.[27]
Ranibizumab, a monoclonal antibody fragment (Fab) derived from bevacizumab, has been developed by Genetech for intraocular use. In 2006, FDA approved the drug for the treatment of neovascular age-related macular degeneration (wet AMD). The drug had undergone three successful clinical trials by then.[28]
In the October 2006 issue of the New England Journal of Medicine (NEJM), Rosenfield, et al. reported that monthly intravitreal injection of ranibizumab led to significant increase in the level of mean visual acuity compared to that of sham injection. It was concluded from the two-year, phase III study that ranibizumab is very effective in the treatment of minimally classic (MC) or occult wet AMD (age-related macular degeneration) with low rates of ocular adverse effects.[29]
Another study published in the January 2009 issue of Ophthalmology provides the evidence for the efficacy of ranibizumab. Brown, et al. reported that monthly intravitreal injection of ranibizumab led to significant increase in the level of mean visual acuity compared to that of photodynamic therapy with verteporfin. It was concluded from the two year, phase III study that ranibizumab was superior to photodynamic therapy with verteporfin in the treatment of predominantly classic (PC) Wet AMD with low rates of ocular adverse effects.[30]
Although the efficacy of ranibizumab is well-supported by extensive clinical trials,[citation needed] the cost effectiveness of the drug is questioned. Since the drug merely stabilizes patient conditions, ranibizumab must be administered monthly. At a cost of $2,000.00 per injection, the cost to treat wet AMD patients in the United States is greater than $10.00 billion per year. Due to high cost, many ophthalmologists have turned to bevacizumab as the alternative intravitreal agent in the treatment of wet AMD. The drug costs $15.00 to 50.00 in the United States.
In 2007, Raftery, et al. reported in the British Journal of Ophthalmology that, unless ranibizumab is 2.5 times more effective the bevacizumab, ranibizumab is not cost-effective. It was concluded that the price of ranibizumab would have to be drastically reduced for the drug to be cost-effective.[31]
Off-label use of intravitreal bevacizumab has become a widespread treatment for neovascular age-related macular degeneration.[32] Although the drug is not FDA-approved for non-oncologic uses, some studies[which?] suggest that bevacizumab is effective in increasing visual acuity with low rates of ocular adverse effects. However, due to small sample size and lack of randomized control trial, the result is not conclusive.
In October 2006, the National Eye Institute (NEI) of the National Institutes of Health (NIH) announced that it would fund a comparative study trial of ranibizumab and bevacizumab to assess the relative efficacy and ocular adversity in treating wet AMD. This study, called the Comparison of Age-Related Macular Degeneration Treatment Trials (CATT Study), will enroll about 1,200 patients with newly diagnosed wet AMD, randomly assigning the patients to different treatment groups.[citation needed]
By May 2012, anti-VEGF treatment with Avastin has been accepted by Medicare, is quite reasonably priced, and effective. Lucentis has a similar but smaller molecular structure to Avastin, and is FDA-approved (2006) for treating MacD, yet remains more costly, as is the more recent (approved in 2011) EYLEA (aflibercept). Tests on these treatments are ongoing relative to the efficacy of one over another.
See also
- Proteases in angiogenesis
- Withaferin A, a potent inhibitor of angiogenesis
- ↑ 1.0 1.1 Senger, DR; Galli, SJ; Dvorak, AM; Perruzzi, CA; Harvey, VS; Dvorak, HF (25 February 1983). "Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.". Science (New York, N.Y.) 219 (4587): 983–5. PMID 6823562. doi:10.1126/science.6823562.
- ↑ Cooper, Mark; Dimitria Vranes; Sherif Youssef; Steven A. Stacker; Alison J. Cox; Bishoy Rizkalla; David J. Casley; Leon A. Bach; Darren J. Kelly; Richard E. Gilbert (November 1999). "Increased Renal Expression of Vascular Endothelial Growth Factor (VEGF) and Its Receptor VEGFR-2 in Experimental Diabetes" (PDF). Diabetes 48 (11): 2229. doi:10.2337/diabetes.48.11.2229. Retrieved 6 November 2013.
- ↑ Ferrara, N; Henzel, WJ (15 June 1989). "Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells.". Biochemical and biophysical research communications 161 (2): 851–8. PMID 2735925. doi:10.1016/0006-291x(89)92678-8.
- ↑ Tischer, E; Mitchell, R; Hartman, T; Silva, M; Gospodarowicz, D; Fiddes, JC; Abraham, JA (25 June 1991). "The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.". The Journal of biological chemistry 266 (18): 11947–54. PMID 1711045.
- ↑ Christinger, Hans W.; Muller, Yves A.; Berleau, Lea T.; Keyt, Bruce A.; Cunningham, Brian C.; Ferrara, Napoleone; de Vos, Abraham M. (November 1996). "Crystallization of the receptor binding domain of vascular endothelial growth factor". Proteins: Structure, Function, and Genetics 26 (3): 353–357. doi:10.1002/(SICI)1097-0134(199611)26:3<353::AID-PROT9>3.0.CO;2-E.
- ↑ Muller, YA; Li, B; Christinger, HW; Wells, JA; Cunningham, BC; de Vos, AM (8 July 1997). "Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.". Proceedings of the National Academy of Sciences of the United States of America 94 (14): 7192–7. PMID 9207067. doi:10.1073/pnas.94.14.7192.
- ↑ Muller, YA; Christinger, HW; Keyt, BA; de Vos, AM (15 October 1997). "The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.". Structure (London, England: 1993) 5 (10): 1325–38. PMID 9351807. doi:10.1016/s0969-2126(97)00284-0.
- ↑ de Vries, C; Escobedo, JA; Ueno, H; Houck, K; Ferrara, N; Williams, LT (21 February 1992). "The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.". Science (New York, N.Y.) 255 (5047): 989–91. PMID 1312256. doi:10.1126/science.1312256.
- ↑ Terman, BI; Dougher-Vermazen, M; Carrion, ME; Dimitrov, D; Armellino, DC; Gospodarowicz, D; Böhlen, P (30 September 1992). "Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.". Biochemical and biophysical research communications 187 (3): 1579–86. PMID 1417831. doi:10.1016/0006-291x(92)90483-2.
- ↑ Soker, S; Takashima, S; Miao, HQ; Neufeld, G; Klagsbrun, M (20 March 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.". Cell 92 (6): 735–45. PMID 9529250. doi:10.1016/s0092-8674(00)81402-6.
- ↑ Claesson-Welsh, L. (20 August 2008). "VEGF-B Taken to Our Hearts: Specific Effect of VEGF-B in Myocardial Ischemia". Arteriosclerosis, Thrombosis, and Vascular Biology 28 (9): 1575–1576. doi:10.1161/ATVBAHA.108.170878.
- ↑ A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2 doi:10.1007/s00018-006-6254-9
- ↑ Shin, Y. J., J. S. Choi, et al. (2010). "Induction of vascular endothelial growth factor receptor-3 mRNA in glial cells following focal cerebral ischemia in rats." J Neuroimmunol 229(1-2): 81-90.
- ↑ cancerpublications.com.
- ↑ 15.0 15.1 Holmes, Katherine; Roberts, Owain Ll; Thomas, Angharad M.; Cross, Michael J. (2007). "Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition". Cellular Signalling 19 (10): 2003–12. PMID 17658244. doi:10.1016/j.cellsig.2007.05.013.
- ↑ Karkkainen, M.J.; Petrova, T.V. (2000). "Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis". Oncogene 19 (49): 5598–5605. PMID 11114740. doi:10.1038/sj.onc.1203855.
- ↑ Ali, Ibne et al. (2013)"Expression and localization of locally produced growth factors regulating lymphangiogenesis during different stages of the estrous cycle in corpus luteum of buffalo" (Bubalus bubalis). Theriogenology http://www.sciencedirect.com/science/article/pii/S0093691X13004263
- ↑ Harmey, Judith (2004). VEGF and cancer. Georgetown, Tex: Landes Bioscience/Eurekah.com New York, N.Y. Kluwer Academic/Plenum Publishers. ISBN 0-306-47988-5.
- ↑ Oltmanns, K. M.; Gehring, H; Rudolf, S; Schultes, B; Hackenberg, C; Schweiger, U; Born, J; Fehm, H. L.; Peters, A (2006). "Acute hypoxia decreases plasma VEGF concentration in healthy humans". AJP: Endocrinology and Metabolism 290 (3): E434–9. PMID 16219663. doi:10.1152/ajpendo.00508.2004.
- ↑ Amo, Y.; Masuzawa, M.; Hamada, Y.; Katsuoka, K. (2004). "Serum concentrations of vascular endothelial growth factor-D in angiosarcoma patients". British Journal of Dermatology 150 (1): 160–1. PMID 14746640. doi:10.1111/j.1365-2133.2004.05751.x.
- ↑ Liu, E.; Morimoto, M.; Kitajima, S.; Koike, T.; Yu, Y.; Shiiki, H.; Nagata, M.; Watanabe, T.; Fan, J. (2007). "Increased Expression of Vascular Endothelial Growth Factor in Kidney Leads to Progressive Impairment of Glomerular Functions". Journal of the American Society of Nephrology 18 (7): 2094–104. PMID 17554151. doi:10.1681/ASN.2006010075.
- ↑ Andraweera, P. H.; Dekker, G. A.; Roberts, C. T. (2012). "The vascular endothelial growth factor family in adverse pregnancy outcomes". Human Reproduction Update 18 (4): 436–457. PMID 22495259. doi:10.1093/humupd/dms011.
- ↑ Bergers G, Hanahan D (August 2008). "Modes of resistance to anti-angiogenic therapy". Nat. Rev. Cancer 8 (8): 592–603. PMC 2874834. PMID 18650835. doi:10.1038/nrc2442.
- ↑ Ebos, John; Christina R. Lee; William Cruz-Munoz; Georg A. Bjarnason; James G. Christensen; Robert S. Kerbel (March 2009). "Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis". Cancer Cell 15 (3): 232–239. PMID 19249681. doi:10.1016/j.ccr.2009.01.021. Retrieved 22 October 2012.
- ↑ Pàez-Ribes, Marta; Allen, Elizabeth; Hudock, James; Takeda, Takaaki; Okuyama, Hiroaki; Viñals, Francesc; Inoue, Masahiro; Bergers, Gabriele; Hanahan, Douglas; Casanovas, Oriol (March 2009). "Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis". Cancer Cell 15 (3): 220–231. PMC 2874829. PMID 19249680. doi:10.1016/j.ccr.2009.01.027. Retrieved 22 October 2012.
- ↑ 26.0 26.1 Braithwaite T, Nanji AA, Greenberg PB (2010). "Anti-vascular endothelial growth factor for macular edema secondary to central retinal vein occlusion". Cochrane Database Syst Rev 10: CD007325. PMID 20927757. doi:10.1002/14651858.CD007325.pub3.
- ↑ Shah DK, Menon KM, Cabrera LM, Vahratian A, Kavoussi SK, Lebovic DI (April 2010). "Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro". Fertil. Steril. 93 (6): 2042–7. PMC 2847675. PMID 19342033. doi:10.1016/j.fertnstert.2009.02.059.
- ↑ "FDA Approves New Biologic Treatment for Wet Age-Related Macular Degeneration". FDA News & Events. June 30, 2006. Retrieved 17 April 2013.
- ↑ Brown, David M.; Michels, Mark; Kaiser, Peter K.; Heier, Jeffrey S.; Sy, Judy P.; Ianchulev, Tsontcho; Anchor Study, Group (2009). "Ranibizumab versus Verteporfin Photodynamic Therapy for Neovascular Age-Related Macular Degeneration: Two-Year Results of the ANCHOR Study". Ophthalmology 116 (1): 57–65. PMID 19118696. doi:10.1016/j.ophtha.2008.10.018.
- ↑ Rosenfeld, Philip J.; Brown, David M.; Heier, Jeffrey S.; Boyer, David S.; Kaiser, Peter K.; Chung, Carol Y.; Kim, Robert Y.; Marina Study, Group (2006). "Ranibizumab for Neovascular Age-Related Macular Degeneration". New England Journal of Medicine 355 (14): 1419–31. PMID 17021318. doi:10.1056/NEJMoa054481.
- ↑ Raftery, J.; Clegg, A.; Jones, J.; Tan, S. C.; Lotery, A. (2007). "Ranibizumab (Lucentis) versus bevacizumab (Avastin): modelling cost effectiveness". British Journal of Ophthalmology 91 (9): 1244–6. PMC 1954941. PMID 17431015. doi:10.1136/bjo.2007.116616.
- ↑ Patent Docs: Genentech Acts to Halt Off-label Use of Avastin® for Age-related Macular Degeneration
Further reading
- Bengoetxea H, Argandoña EG, Lafuente JV (2008). "Effects of Visual Experience on Vascular Endothelial Growth Factor Expression during the Postnatal Development of the Rat Visual Cortex". Cerebral Cortex. 18 (7): 1630–39. PMC 2430152. PMID 17986606. doi:10.1093/cercor/bhm190.
- Zan L, Wu H, Jiang J, Zhao S, Song Y, Teng G, Li H, Jia Y, Zhou M, Zhang X, Qi J, Wang J. (2011). "Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema". Neurochem Int. 58 (8): 872–9. PMC 3100427. PMID 21334414. doi:10.1016/j.neuint.2011.02.014.
- Zan L, Zhang X, Xi Y, Wu H, Song Y, Teng G, Li H, Qi J, Wang J. (2014). "Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion". Neuroscience. 262: 118–28. PMC 3943922. PMID 24412374. doi:10.1016/j.neuroscience.2013.12.060.
- Wang J, Fu X, Jiang C, Yu L Wang M, Han W, Liu L, Wang J. (2014). "Bone marrow mononuclear cell transplantation promotes therapeutic angiogenesis via upregulation of the VEGF-VEGFR2 signaling pathway in a rat model of vascular dementia". Behav Brain Res. 265: 171–80. PMC 4000455. PMID 24589546. doi:10.1016/j.bbr.2014.02.033.
- Ferrara N, Gerber HP (2002). "The role of vascular endothelial growth factor in angiogenesis". Acta Haematol. 106 (4): 148–56. PMID 11815711. doi:10.1159/000046610.
- Orpana A, Salven P (2003). "Angiogenic and lymphangiogenic molecules in hematological malignancies". Leuk. Lymphoma 43 (2): 219–24. PMID 11999550. doi:10.1080/10428190290005964.
- Afuwape AO, Kiriakidis S, Paleolog EM (2003). "The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis". Histol. Histopathol. 17 (3): 961–72. PMID 12168808.
- de Bont ES; Neefjes VM; Rosati S et al. (2003). "New vessel formation and aberrant VEGF/VEGFR signaling in acute leukemia: does it matter?". Leuk. Lymphoma 43 (10): 1901–9. PMID 12481883. doi:10.1080/1042819021000015844.
- Ria R; Roccaro AM; Merchionne F et al. (2003). "Vascular endothelial growth factor and its receptors in multiple myeloma". Leukemia 17 (10): 1961–6. PMID 14513045. doi:10.1038/sj.leu.2403076.
- Caldwell RB; Bartoli M; Behzadian MA et al. (2004). "Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives". Diabetes Metab. Res. Rev. 19 (6): 442–55. PMID 14648803. doi:10.1002/dmrr.415.
- Patan S (2004). "Vasculogenesis and angiogenesis". Cancer Treat. Res. Cancer Treatment and Research 117: 3–32. ISBN 978-1-4020-7704-3. PMID 15015550. doi:10.1007/978-1-4419-8871-3_1.
- Machein MR, Plate KH (2004). "Role of VEGF in developmental angiogenesis and in tumor angiogenesis in the brain". Cancer Treat. Res. Cancer Treatment and Research 117: 191–218. ISBN 978-1-4020-7704-3. PMID 15015562. doi:10.1007/978-1-4419-8871-3_13.
- Eremina V, Quaggin SE (2004). "The role of VEGF-A in glomerular development and function". Curr. Opin. Nephrol. Hypertens. 13 (1): 9–15. PMID 15090854. doi:10.1097/00041552-200401000-00002.
- Storkebaum E, Lambrechts D, Carmeliet P (2004). "VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection". BioEssays 26 (9): 943–54. PMID 15351965. doi:10.1002/bies.20092.
- Ribatti D (2005). "The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review". Br. J. Haematol. 128 (3): 303–9. PMID 15667531. doi:10.1111/j.1365-2141.2004.05291.x.
- Loureiro RM, D'Amore PA (2005). "Transcriptional regulation of vascular endothelial growth factor in cancer". Cytokine Growth Factor Rev. 16 (1): 77–89. PMID 15733833. doi:10.1016/j.cytogfr.2005.01.005.
- Herbst RS, Onn A, Sandler A (2005). "Angiogenesis and lung cancer: prognostic and therapeutic implications". J. Clin. Oncol. 23 (14): 3243–56. PMID 15886312. doi:10.1200/JCO.2005.18.853.
- Pufe T; Kurz B; Petersen W et al. (2006). "The influence of biomechanical parameters on the expression of VEGF and endostatin in the bone and joint system". Ann. Anat. 187 (5–6): 461–72. PMID 16320826. doi:10.1016/j.aanat.2005.06.008.
- Tong JP, Yao YF (2006). "Contribution of VEGF and PEDF to choroidal angiogenesis: a need for balanced expressions". Clin. Biochem. 39 (3): 267–76. PMID 16409998. doi:10.1016/j.clinbiochem.2005.11.013.
- Lambrechts D, Carmeliet P (2007). "VEGF at the neurovascular interface: therapeutic implications for motor neuron disease". Biochim. Biophys. Acta 1762 (11–12): 1109–21. PMID 16784838. doi:10.1016/j.bbadis.2006.04.005.
- Matsumoto T, Mugishima H (2006). "Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis". J. Atheroscler. Thromb. 13 (3): 130–5. PMID 16835467. doi:10.5551/jat.13.130.
- Bogaert E, Van Damme P, Van Den Bosch L, Robberecht W (2006). "Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases". Muscle Nerve 34 (4): 391–405. PMID 16856151. doi:10.1002/mus.20609.
- Mercurio AM, Lipscomb EA, Bachelder RE (2006). "Non-angiogenic functions of VEGF in breast cancer". Journal of Mammary Gland Biology and Neoplasia 10 (4): 283–90. PMID 16924371. doi:10.1007/s10911-006-9001-9.
- Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling". Curr. Mol. Med. 6 (8): 831–41. PMID 17168735. doi:10.2174/156652406779010795.
- Rini BI, Rathmell WK (2007). "Biological aspects and binding strategies of vascular endothelial growth factor in renal cell carcinoma". Clin. Cancer Res. 13 (2 Pt 2): 741s–746s. PMID 17255303. doi:10.1158/1078-0432.CCR-06-2110.
- Rodgers LS, Lalani S, Hardy KM, Xiang X, Broka D, Antin PB, Camenisch TD. (2006). "Depolymerized hyaluronan induces vascular endothelial growth factor, a negative regulator of developmental epithelial-to-mesenchymal transformation". Circ Res. 99 (6): 583–9. PMID 16931798. doi:10.1161/01.RES.0000242561.95978.43.
- Qaum T, Xu Q, Joussen AM, et al.VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci. 2001;42:2408–2413.
External links
- Vascular Endothelial Growth Factors at the US National Library of Medicine Medical Subject Headings (MeSH)
- Proteopedia Vascular_Endothelial_Growth_Factor - the Vascular Endothelial Growth Factor Structure in Interactive 3D


text:
Quest | Men's Event
Within every man is a deep knowing that he was designed for greatness. The dulling of the passion to run towards that calling can be a slow and steady drip or an onslaught of disappointment. In either case, the knowing is there, even if the fire has been reduced to an ember. It's time to realize the fullness of your design and the purpose that fuels your destiny. It's a journey that takes a lifetime which can start with an intentional effort to reignite the passion. It can start with Quest.
Discover the Passion in You
Quest is a 5.5 day catalyst to realize who you are and what you are capable of. Everything else will be set aside for the purpose of passionate pursuit. The singular focus and elimination of the daily routine will posture you for realization of the potential for extraordinary. As you draw closer, you will not be disappointed in the faithful response.


text:
Classification of Electroencephalograms Using Machine Learning AlgorithmsName : Dr. Jose Joaquín Rodríguez García
Affliation : Professor
University : University of Alicante
Country : Spain
This work is a compilation of applications of techniques and mathematical tools, together with the scientific basis that gives us the field of medicine, to electroencephalogram (EEG) data collected in healthy children and children with attention deficit and hyperactivity disorder (ADHD). The objective of this study is to automatically diagnose ADHD in children using the EEG data collected from 85 children with ADHD and 83 healthy children.
Materials & Methods: The Fourier Transform, signal filtering, Independent Component Analysis (ICA), discrete Wavelet Transform, k-nearest neighbors (KNN) algorithm and k-fold cross validation.
Results: The results obtained have been a classification whose accuracy has been higher than 80%.
Conclusions: There is a remarkable relationship between the EEG data from a patient and to be diagnosed as ADHD. It opens the possibility of repeating the same study with a greater number of patients and other different mental pathologies.
Biography: Jose Joaquín was born in Villarrobledo, a town located near Albacete in Spain. From an early age, he became interested in electronic devices, so when he finished high school he began to study telecommunications engineering in the University. After that he was working in Holland during a year and a half. He then began and finished his mathematics studies at his age of 26.


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On October 12-13, 1994, a Forum on Global Change Modeling was held at the invitation of the Subcommittee on Global Change Research (SGCR) to help address requests from the White House Office of Science and Technology Policy (OSTP) and from Congressman Dingell to the General Accounting Office (GAO). The Forum labored to produce a consensus document and to provide the GAO representatives a sense of the debate on issues related to the use of climate models to inform policy. The charge to the panel and the report are attached [see caveat].
The invited participants included Eric Barron (chair), Joyce Penner, Chuck Hakkarinen, Dan Lashof, Jerry Mahlman, Pat Michaels, Roy Jenne, Richard Lindzen, Tamara Ledley, and Tom Wigley; a number of additional scientists were invited, but were only able to submit written comments. In addition, Mike MacCracken, Ken Bergman, Jay Fein, Mike Riches, Lowell Smith, Richard Poore, Robert Schiffer, Dave Goodrich, Courtney Riordan, Ghassem Asrar, Robert Watson, Tony Janetos, Rick Piltz, and Scott Sandgathe participated as agency, congressional, and OSTP representatives.
The report has been positively reviewed by a wider segment of the climate community. Still, the forum participants believe that this report is just a beginning. It includes the judgment of participating experts and reviewers-as opposed to detailed arguments-on the credibility of climate model projections. As an additional step, the community needs to take the next step of elucidating fully the reasons models make the predictions that they do. This effort should be a significant part of a rational approach to determine whether models are behaving reliably. One aspect of this extended process is the thorough international assessment that is being conducted by the Intergovernmental Panel on Climate Change (IPCC), which is due to be published in late 1995. Forum Charge
The charge to those attending the Forum and to those who submitted written comments was to develop a brief statement on the credibility of projections of climate change provided by General Circulation Models (GCMs) as background for potential interpretation of model results in the context of developing and considering national policy options. The focus of this effort was specifically on the climate aspects of the entire global change issue (figure 1) - thus not on the emission scenarios, the consequences of change to ecosystems and natural resource systems, or the socio-economic implications and potential for responses.
The attendees at the Forum decided to develop an ordered list of statements from "virtually certain" to "uncertain" that summarizes the major findings and implications stemming from climate system model experiments (most commonly with GCMs) and the issues being debated in the scientific literature, and to express these statements in terms that indicate their potential policy relevance. The participants agreed to include with each ranked statement the basis for the consensus view. In addition, the participants at the Forum agreed to provide indications of where opportunities exist for early progress in reducing uncertainties and improving confidence in model projections. The report that follows consists of three parts. First, a number of conclusions are identified as "virtually certain," based on observations, experiments, and models. These conclusions provide a significant starting point for discussion, yet they do not directly stem from climate system model experiments. These statements are provided in Part 1 as an introduction. Second, Part 2 provides the ranked statements that refer to model experiments and predictions. Finally, a list of opportunities for early progress in reducing uncertainties is given in Part 3.
Go to Part 1. Introduction


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stubby wrote:*CRAZYHORSE* wrote:But how will an airplane ever find any cover to become completely invisible. I know are some rare cases in which they can but this is the reason I think it should be an ability that can be activated like a stealth field.
Just fly off the battlefield. If it's too far away to see, or ducks under the edge of the table, then it's invisible.
A few years ago my friend rushed a whole squad of elite marines UNDER the table and took out my entire artillery battery.


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Scientist I, Medicinal Chemistry
- Employer
- Celgene
- Location
- San Diego, CA
- Posted
- Jun 18, 2018
- Ref
- 1800926
- Discipline
- Science/R&D, Biotechnology, Chemistry
- Hotbed
- Ideal Employer
- Required Education
- Bachelors Degree
- Position Type
- Full time
Other Locations:US- CA- San Diego
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
We are seeking highly motivated, talented, and energetic chemist to join our fast-paced discovery research chemistry group based in San Diego, CA.
Responsibilities will include, but are not limited to, the following:
Design, synthesize, and characterize novel bioactive molecules towards a wide range of novel protein targets, in an efficient and independent manner. Integrate and interpret the SAR and identify lead compounds with desirable properties (activity, selectivity, DMPK characteristics, physical properties, etc.). Apply structure-based drug design principles and integrate with other experimental data collected in the design of new molecules. Work with other chemists (both internally and externally) to solve synthetic challenges, and design novel molecules. Maximize the productivity of the group and provide intellectual input to the department. Maintain productive relationships with project team members and communicate progress against goals in a multidisciplinary setting: chemistry, biology, pharmacology, modeling, and external collaborators.
Skills / Knowledge Required:
- PhD in organic or medicinal chemistry with preference for 2 years of post-doctoral or industrial experience in synthetic organic chemistry / drug discovery. Bachelor's degree in a scientific discipline with at least 12 years work experience or Master's degree with at least 10 years work experience.
- Demonstrated record of productivity in organic or medicinal chemistry research as evidenced by publications and/or patents.
- Passionate about hands-on organic synthesis with a broad knowledge of modern organic chemistry and synthetic methods: heterocyclic chemistry, metal catalyzed reactions, multi-step synthesis; in-depth knowledge and hands-on experience with a wide range of techniques in synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.).
- Experience using the concepts and tools of structure-based drug design and chemical database searching.
- Highly collaborative, self-motivated, team-oriented individual, with good computer skills.
- Ability to work in a fast-paced, highly integrated team environment where accuracy, accountability and timeliness are essential.
- Excellent oral and written communication skills.
#LI-POSTCelgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.


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MBBCh (Witwatersrand), FCP (SA) with Paediatrics, MRCP (UK), FRCPCH, MD (Birmingham)
Dr Hulton completed her undergraduate and early postgraduate medical training in South Africa from where she also obtained her Fellowship of the College of Physicians in 1989. She then worked at the Hospital for Sick Children Great Ormond Street, London for 3 years and gained her membership of the Royal College of Physicians in 1992. In 1994 she became a Fellow of the Royal College of Paediatrics and Child Health and in 1996 was awarded a Doctorate of Medicine from the University of Birmingham for her thesis pertaining to immune modulation and the nephrotic syndrome. Her appointment in 1995 as Consultant in Paediatric Nephrology at The Birmingham Childrens Hospital, one of the largest paediatric renal units in the United Kingdom, serves a population of 6.5 million. She subsequently developed an interest inherited metabolic disorders and tubular disorders affecting the kidney and is the Lead Physician for renal metabolic disease. The Birmingham Childrens Hospital is the only UK centre performing combined liver and kidney transplants for infants and children. On behalf of the British Association for Paediatric Nephrology, she has developed a national registry for hyperoxaluria and provides national and international advice on the management of children and adults with primary hyperoxaluria. She is the chair of the Primary Hyperoxalurias UK Rare Disease Group.
Dr Hulton is also an examiner for the Royal College of Paediatrics and Child Health, expert member of the Birmingham Childrens Hospital Ethics Advisory Committee, acted as Chair of the College Specialist Advisory Committee for Education and Training for the UK from 2004-2009, regularly acts as a referee for a number of scientific journals as well as a referee for grant applications for the National Kidney Research Fund and Kidney Research UK.
Online PH-Registry available here


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Undine is a set of elemental launchers first appearing in Bayonetta 2. As well as being used for heavy melee attacks, they can shoot fire or ice at enemies to either burn them or freeze them solid for an easy break. They appear to act as a replacement for Durga from the first game, another set of elemental based weapons.
In-Game Description
"Two flamethrowers containing the soul of Undine, who threw herself into the Coctycus river after a failed relationship.
Undine's extreme feelings of jealousy burst into searing flame, reducing her enemies to ash. Her breath of lament freezes all who are hit by it dead in their tracks."
How To Obtain
During Chapter IV, Verse 1, the first half appears after the battle with Fidelity. The second half can be found in Verse 6 after fighting Urbane. After the cutscene with Loki and The Masked Lumen, found in the rubble on the right after going straight. It's the third weapon you can obtain in the game. Even though you get the first half automatically, it's hard to miss the second one a couple of verses later. The alternative set can be purchased at the Gates of Hell for 49800 Halos.
Unique Traits
Much like Durga before it, Undine's most notable unique trait is its ability to switch between two elemental states; one of fire and one of ice. The elements can be shot out by holding the appropriate button, with the ice able to freeze an enemy into a solid block and make them vulnerable to other attacks. Like Durga, Undine can be welded on both hands and feet simultaneously.
In Umbran Climax, Undine summons Hydra to sweep and jab at enemies from all angles. The demon appears drenched in either fire or ice depending on the element chosen.
RusalkaRusalka is Jeanne's equivalent of the Undine. The framework of Rusalka are colored silver and gold as opposed to Undine's black color.
In-Game Description:
"An infernal weapon containing the souls of lonely water spirits, known as Rusalka, who failed to become brides. The screams of their souls as they escape the machine are at times horrible flames of destruction, or blizzards of the coldest temperatures."
- Undine is possibly a reference to the alchemical works of Paracelsus; Undine are Nymphs representing the element of water. How the weapon uses fire and ice represents the extremes that come to manifest the median stable of liquid water.
- The demon's themes of jilted love is likely a reference to the famous 1811 fairy tale novel of the same name; along with many other literature and film themes, the novel was adapted into theatrical performances, ballet shows, and opera pieces, one of which made famous the actress Audrey Hepburn.
- Rusalki (plural form of Rusalka) are sea nymphs, spirits, or mermaids from Slavic mythology.
- The weapon form seems similar to either gust generating bellows or a pair of Japanese Kanabō, perhaps even a pair of heavily modified billy clubs.
|Bayonetta (Gallery) • Jeanne (Gallery) • Zero • Enzo • Rodin (Gallery) • Luka • Cereza (Gallery) • Antonio Redgrave • Umbran Elder • Rosa • Father Balder (Gallery) • Jubileus the Creator • Eva
|Masked Lumen (Gallery) • Loki • Loptr • Aesir
|Handguns • Scarborough Fair • Onyx Roses • Shuraba • Kulshedra • Durga • Odette • Lt. Col. Kilgore • Sai Fung • Bazillions • Pillow Talk • Rodin • All 4 One
|Love Is Blue • Rakshasa • Alruna • Kafka • Chernobog • Undine • Takemikazuchi • Salamandra • Master Sword • Arwing Guns • Chain Chomp • Umbran Armor • Unforgiven • Holy Glaive
|Affinity • Dear and Decorations • Enchant • Applaud • Ardor • Irenic • Beloved • Kinship • Fairness • Grace and Glory • Fearless • Harmony • Inspired • Braves • Gracious and Glorious • Joy
|Acceptance • Belief • Accolade • Valiance • Cachet & Compassion • Urbane • Enrapture • Fidelity • Gravitas • Allegiance • Hideous • Hatred • Fury • Pain • Pride • Greed • Malicious • Resentment • Sloth
|Contracted Demons • Gomorrah • Malphas • Hekatoncheir • Scolopendra • Phantasmaraneae • Little Devils • Madama Butterfly • Madama Styx • Queen Sheba
|Labolas • Mictlantecuhtli • Baal • Hydra • Diomedes • Carnage • Madama Khepri • Omne • Fortitudo • Temperantia
|Golem • Fortitudo • Temperantia • Iustitia • Sapientia • Father Balder • Jeanne • Jubileus the Creator •
Father Rodin
|Gomorrah • Valiance • Glamor • Masked Lumen • Valor • Insidious • Prophet • Alraune • Balder • Loptr • Aesir • Rodin, The Infinite One


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The ruins of Morioka Castle, which used to be called Kozukata Castle, has now become part of the Morioka Castle Site Park (Iwate Park), where citizens come relaxing.
|1-1 Satsuki-cho, Miyako-shi
|Getting there
|7 minutes by bus from JR Morioka Station and a minute's walk from the stop in front of the Morioka Castle Site Park.
|Parking information
|Available for large-sized buses as well as automobiles.


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New study of complications after fertility treatments
Dr. Kirsty Horsey
Progress Educational Trust29 November 2005
Women who undergo repeated cycles of IVF treatment are at higher risk of complications than women who just take medicines to stimulate egg production, say Finnish researchers. However, the risks of complications are low after each individual IVF cycle, say the researchers, who are based at the National Research and Development Centre for Welfare and Health in Helsinki. The team, who published their findings in the journal Human Reproduction, say they carried out the study because the frequency and importance of complications following IVF treatment are 'poorly known'.
The scientists studied records for 9175 women who received IVF treatment and 10,254 who had ovulation induction treatment during 1996-1998 in Finland. They found that the rate of ovarian hyperstimulation syndrome (OHSS) was 1.4 per cent after the first IVF treatment cycle, rising to 2.3 per cent over the whole study period. However, the rates in women who just received ovulation induction treatment were 'very low'.
The team also found that overall, 15 per cent of the IVF-treated women and eight per cent of the women who received ovulation induction treatment needed hospital treatment at least once. The reasons included ectopic pregnancy and miscarriages, as well as OHSS. Infections and bleeding were not common after IVF, and 'even rarer' after ovulation induction, say the researchers. To be included in the study, hospital treatment had to have occurred within 120 dyas of receiving fertility treatment, or, in the case of ectopic pregnancy and miscarriage, 240 days.
According to a report in the Daily Telegraph, past studies indicate that eight per cent of natural pregnancies result in complications that require hospital treatment - around half the rate of the IVF-treated group in the study. Martin Foley, chief executive of the pro-life charity Life, told the newspaper that 'these side effects of IVF are life-threatening but are not talked about sufficiently.
Reproduced with permission from BioNews, an email and online sources of news, information and comment on assisted reproduction and genetics.


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Wanted Serial Bank Robber Surrenders
Today, Special Agent in Charge Monica M. Miller of the Federal Bureau of Investigation announced David James Lira, 39, of Roseville has surrendered to federal authorities without incident.
Lira was wanted for multiple counts of robbery and attempted robbery of federally insured banks located in the Northern California cities of Roseville, Modesto, Oroville, Tracy, and Dublin. During the reported incidents, witnesses described Lira as wearing disguises, often with large eyeglasses. Witnesses also stated Lira presented demand notes during the commission of the robberies.
According to the criminal complaint filed on March 8, 2016, in the U.S. District Court, Eastern District of California, Lira confessed to the following robberies and attempted robberies:
- Attempted robbery on December 1, 2015
Bank of the West located at 1112 Galleria Boulevard in Roseville
- Robbery on December 3, 2015
Umpqua Bank located at 1801 Douglas Boulevard in Roseville
- Attempted Robbery on December 11, 2015
Delta Bank located at 2711 McHenry Avenue in Modesto
- Robbery on December 11, 2015
Wells Fargo Bank located at 3456 McHenry Avenue in Modesto
- Robbery on December 23, 2015
US Bank Located at 2111 Oro Dam Boulevard East in Oroville
- Robbery on January 6, 2016
US Bank located at 2175 W. Grant Line Road in Tracy.
Lira also confessed to a robbery on December 17, 2015, at Wells Fargo Bank located at 4400 Tassajara Road in Dublin.
Lira will make his first appearance this afternoon in U.S. Magistrate Court at the United States Courthouse in Sacramento. As is always the case, charges set forth in a criminal complaint are merely accusations and do not constitute proof of guilt. Every defendant is presumed to be innocent unless proven guilty.
For more information about other wanted bank robbery suspects, log into the FBI's Wanted Bank Robber website at bankrobbers.fbi.gov.


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While the scoreboard at the Umphrey Center may have been broken due to technical difficulties Monday, the Shelton State Community College men's basketball team was definitely on.
TUSCALOOSA | While the scoreboard at the Umphrey Center may have been broken due to technical difficulties Monday, the Shelton State Community College men's basketball team was definitely on.
The Shelton State Buccaneers beat the Marion Military Institute Tigers 96-73.
"(The start of the game) I saw how hopefully I wanted us to play, not only this game, but further on," Buccaneers head coach Barry Mohun said, "The style we like to play, regardless if the ball goes in, we were really up-tempo and I wanted to keep that going for the full 40 minutes."
The Buccaneers started the game with an impressive run of 3-pointers, making all five attempts and putting Shelton State up 15-0.
"Offensively we did fine, but we need to pick it up in some areas defensively and also rebounds especially," Mohun said.
By halftime, the Buccaneers led the 48-29. Shelton State made nine 3-pointers in the opening minutes alone.
During the first half, the Buccaneers shot 46 percent and out-shot MMI 41-29. Despite being behind, The Tigers were 48 percent from the field.
MMI came out strong the second half, battling back to a 10-point deficit three times. With less than 10 minutes remaining, the Tigers cut the lead to 68-58.
"Shelton State is a good team, that's about it," MMI head coach Marcus Thomas said.
According to Thomas there were no positives his Tigers could take from the game.
Overall, Shelton State was 32-for-68 on field goal attempts, shooting 13-for-31 on 3-pointers. The Buccaneers shot 71 percent from the free-throw line. MMI took more attempts, going 38 for 90.
"They (Tigers) did a good job going to the glass on rebounds," Mohun said, "They fought back but I believe in my team and we believe in ourselves. Towards the end we were just able to wear them down, which was our goal."
Bucs sophomore guard Lazabian Jackson led Shelton State offensively, scoring 24 points with four rebounds. Sophomore forward Fentress Lockett and sophomore guard Terrance Coleman both added 11 points.
"We just need to take care of the little things, like fundamentals, and we'll do well in our next games," Mohun said.
MMI was led by guard Ladarius Howard with 13 points. Sophomore Terry Leake Jr. added six and freshman Eric Russell and Willie Readus added five apiece.
Shelton State will face Wallace-Hanceville Community College on Sunday while MMI will play Lawson State Community College on Thursday.
Shelton State will return to Umphrey Center Feb. 10 to face Gadsden State.


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Follow us:
"If you reject the food, ignore the customs, (...)
and avoid the people, you might better stay at home"
James Michener
Welcome to our Travel Blog!
Hi! We are Reto & Jenny.
This Blog exists since our worldtrip in 2010. So far we have visited close to 60 countries on 5 continents. Our base currently is St. Gall in beautiful Switzerland! Here we share our personal stories about travel, cooking & eating as well as sailing. Our Goal is to inspire you to follow your dreams and travel the world!


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Last year with the encouragement of a few friends I decided to join the 365 Project. Take a picture a day for every day of the year. Of course, this year with it being a leap year it should be the 366 project.
Now that being said I don't manage to take a picture every single day, but I enjoyed the pictures I did take last year and decided to give it a go again this year.
This morning it was 70 degrees outside, very unusual for this time of year even though we have been having a warmer than normal winter. So I decided to take the dog for a walk and take a few pictures. This was one of the plants in the field with a few left over raindrops from our very early morning rain.
|From Just Because
If you think that you might like taking pictures and having an online calendar to display them, then check out www.shuttercal.com. It's a free calendar web-site.


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A Two-day Workshop
March 21-22, 2015
9am – 3pm
Dr. Jeannine Goode-Allen and Dr. David Sharp
Transform limiting obstacles in your life through
creative exploration, tap dance and more!
Using the arts as a doorway to the soul, we will put on tap shoes, create body prayers, do storytelling and dramatic interpretation, use props, and experience communal embodiment and ritual. We will take an important reality in your life that you want to address and transform. We will look at each issue creatively and work to create breakthroughs that will free you to move forward into your best destiny, including having more peace, personal power, joy and gratitude. We will use tap shoes and basics steps as our language to see what there is to stomp and step, acknowledge and honor, remember… and even forgive.
"David and Jeannine, with incredible passion and talent, challenge us to transform our pain into power, moving through our blockages and trauma with grace and beauty." Jan Rupp, Co-author of The Five-Minute Healer.
"David and Jeannine are very loving and accepting. With their encouragement, it allowed me to not only have a hell of a lot of fun, but also to feel free to release my inhibitions and safe to explore deeper parts of myself." Herb Rodriguez, Musician/Artist – Member of The Boulder Chorale
Don't miss this unique opportunity to journey into…YOU.
Viriditas Studio
4939 Broadway, Unit 65
Boulder, Colorado 80304
$125 – includes lunch both days
Workshop limit:12 persons
Register: www.viriditasllc.com


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Product Description
This Art Notebook is a design from my painting, for collect. The notebook planner, has hard cover & spiral bound.
The notebook, ideal for gift, is a design full colors in two laminated glossy covers, has 100 white lined sheets for writing comfort.
Size: 5.82″ x 8.26″ (14,8 x 21 cm.) 100 white lined sheets (200 pages)
Paper 70 g/m2 Hardcover is glossy laminated
The sheets of the notebook, have a marked cut line and 2 holes for archiving if desired, once cut off from the notebook.


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Medical questions & health advice by board certified doctors
"Should my friend get tested for HIV?"
My friend has been sexually active for two years with around 3 guys. Sometimes protected/unprotected. She's really nervous to get tested. If she takes a home test and it says she has hiv and she wants to take medication for it, does she still have to take a test at the doctors office in order to get diagnosed. She just wants it to be really private and confidential. Or does she have a better chance not taking the test and just make sure she takes vitamins for her immune system. She only asks this because once your diagnosed you have to tell your partner.
This is an excellent question. Your friend should definitely speak with her health care provider because there are several things that are concerning regarding her history. First, because she has had multiple partners, it is very important that she practice safe sex whenever having sexual intercourse. This is important not only because of the possibility of an unwanted pregnancy, but also to avoid any sexually transmitted diseases such as chlamydia, gonorrhea, HIV, or hepatitis C. Your friend should be counselled that she is putting herself and her sexual partners at risk when deciding not to use protection. Second, with regards to her HIV status, if your friend has concerns that she has contracted a sexually transmitted disease, it is important that she see her health care professional as he or she will be able to test her for any possible sexually transmitted diseases, such as the ones mentioned earlier. This is important because several of these STDs are treatable with medication, and if they are left untreated for long periods of time, can go on to become more serious. Taking vitamins will not protect her from any of these diseases and so it is very important that your friend see a health care professional.
Need more info?See a primary care-doctor today
Zocdoc Answers is for general informational purposes only and is not a substitute for professional medical advice. If you think you may have a medical emergency, call your doctor (in the United States) 911 immediately. Always seek the advice of your doctor before starting or changing treatment. Medical professionals who provide responses to health-related questions are intended third party beneficiaries with certain rights under Zocdoc's Terms of Service.


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I really want to be able to sew without patterns. Don't get me wrong I LOVE patterns. I look for them every time I go to a fabric store, or even better, a thrift store. I own dozens of them. I just really love the idea of someday being able to sell what I make, without worrying about copyright infringement and lawsuits and stuff.
Next time I make one I think I am going to take photographs while I make it so I can post my first (only?) tutorial.
Do you use patterns when you sew, or do you make your own?
This post may be linked up at one of these wonderful blog hops:


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hengki koentjoro
see: black and white photography by hengki koentjoro from indonesia
i always feel proud when i found amazing works from fellow indonesian through other sites, especially i found hengki's works from one of the blogs that i adore miss moss. do you have any favourite artist / designer / photographer from your home country that you'd like to share with me?
ps thank you so much for all of your nice comments on my previous post about my travel photos in india, they make me happy!


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This 3 Bedroom, 2 Bathroom, 2 storey modern home has everything required for the perfect location that it finds itself in, it also exudes design excellence and class the entire way through this lovely home.
Comprising of 2 bedrooms downstairs, living zone, and laundry, also access to the lovely rear yard. When you step upstairs you will continue to admire the quality hardwood flooring, open plan kitchen with dishwasher / dining/ living area, including the master bedroom, with ensuite. You will enjoy an earthy and cosy feel throughout those cold winters days with the reverse cycle air conditioner/heater and stunning ocean outlooks from the large back deck, whilst relaxing with BBQs and drinks. The second balcony is positioned to allow you to sit and take in the gorgeous landscaped garden at the front of the home. All only a few hundred meters walk from one of the best beaches on the island.
Please provide your own top and bottom sheets, towels, bathmats, pillow cases and tea towels. If you require a linen hire service, please contact Glenda Binch'sLinenHire at email@example.com call 0428 170 117.
If at any time we find you are accommodating more people than you have booked for, you will be evicted immediately and extra charges may apply.
It is a requirement of our owners to obtain ages and number of guests staying at this property. Please provide ages upon booking request.
You will be required to sign Terms & Conditions and provide our office with a copy of your Drivers License & Credit Card prior to your arrival.
All bookings are subject to owner confirmation.
A $33 booking fee will apply to the total amount of your booking.
Contact us on (03)5952 6633 or email firstname.lastname@example.com


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Cloud Storage: Adoption, Practice and Deployment
* All fields required.
In the Whitepaper:
Leading analyst firm Storage Strategies NOW presents a comprehensive report on the state of the cloud storage market and of the storage services that are layered atop of it. This report includes:
- A definition of cloud storage
- Discusses how cloud storage is deployed
- Cloud storage trends
- Surveys IT professionals on their expectations of the cloud storage market
- Provides a detailed look at Gluster Virtual Storage Appliances.


text: Description : Rajgad fort in Pune, was once the capital of Maratha king. It is a beautiful palace on Sahyadri range once administered by the great Chatrapati Shivaji Maharaj. This particular fort has a rich history; hence, it is quite favourite amongst the people of Maharashtra. It also amongst the most popular trekking spots in Maharashtra.


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"I just couldn't design a cookware line without adding a collection of beautiful oven-to-table stoneware. They're essential for some of my favorite recipes, like sweet and savory pies, quick breads and meatloaf, and of course, casseroles galore. I like how they look and feel just like hand-thrown pottery, and the raised swirl pattern makes my heart sing!" Best Dishes! - Paula Deen
Browse Paula Deen Stoneware


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- Generate a template from Smart Tuition in excel format via Saved Custom Reports or exporting a list via Manage Families.
- Required fields for family based billing templates:
- Smart Tuition Family ID #
- Family Name
- School Family ID # if applicable
- Fee or Discount name
- Dollar amount to be billed
- Required field for student based billing templates:
- Smart Family ID #
- Student Name
- School Student ID if applicable
- Fee or Discount name
- Dollar amount to be billed
- Do not change any information in the template generated from Smart Tuition.
- Do not include formulas; include values only.
- Indicate if the item is a Fee or Discount.
- Indicate the billing month.
Blackbaud Community
Connect and collaborate with fellow Blackbaud users.


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Police unit involved in 3-vehicle crash
There were no injuries in a three-vehicle crash about 10:30 a.m. Monday, April 6, 2015, at Fifth and Date. A 1994 Chevy Astro van driven by John LaFuente, 76, was traveling west on Fifth Street when it turned left in front of a 2014 Chevy Impala patrol unit traveling east and driven by Plainview Police Patrol Officer Brandon Hodges, 31. Those two vehicles collided in the intersetion, with the Astro van then striking a 1993 Buick Roadmaster driven by Calvin Dale Fraizer, 66, of Plainview. The Buick, traveling north on Date Street, was stopped for a traffic light. There were no injuries and LaFuente was issued a citation for failing to yield to oncoming traffic while making a left turn. All three vehicles had to be towed from the scene.


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All items > Shop by Brand > Benchmade > Benchmade Knife Accessories
- Brand:Benchmade
- Length:5.50"
- Width:2.50"
- Carry:Belt
- Material:Cordura
- Model:Sheath
- Country of Origin:USA
- Product Type:Sheath
For those individuals who prefer to carry their knives in a sheath, we offer a simple but effective design, which is available in several sizes (other sizes/styles are available on our website HERE). All soft sheaths are made of 1680 denier poly-ballistic nylon with liners and they are edged with nylon for a clean, no-snag finish. They feature Velcro® closures. 5.5" x 2.5"


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Condensation, mould, mildew growth and dust mites are proving to be a major issue in New Zealand households.
The problems that result for your family are asthma and allergies and these issues are compounded in the winter months. Did you know that dust mites need a damp environment to proliferate?
It seems people's current concerns with security issues and energy efficiency can result in the home being closed up like a sealed box!
Generally in the winter we tend to keep our houses sealed up in order to retain heat that we have paid to generate and to keep the cold air out. Warm air retains moisture better than cool air, so humidity will build up. When warm air contacts a cooler area such as glass windows, condensation occurs. Over time this results in mould, mildew and the perfect conditions for dust mites to breed. This is where Degrees Ahead can help.
We provide high quality systems which can ventilate your home 24 hours a day 7 days a week. In the past a limited solution would be to open a window but this does not allow adequate ventilation and posesses a high security risk.
Our systems pass the ventilated air through a high grade heat exchanger and filter before being gently distributed around the home via diffusers set in the ceiling at strategic points. The continuous circulation of fresh dry air creates a positive pressure in the home which pushes the damp stale air out of the home.
Greatly reduce condensation, mould mildew, damp and other airborne contaminants in your living spaces.
Introduce clean fresh air whilst maintaining the security of your home.
Provide a clean healthy living environment in your home.
Drive moisture and contaminants out.
Continue to provide fresh cool air during the summer months and on hot days during Autumn, Winter and Spring.
Saves money on your heating and cooling costs.
Integrated into some of our systems is a heat transfer feature which recovers excess heat from your heat source to warm the rest of your home.
Fully comprehensive control system in the form of a wall controller which can give you up-to-date readings on your home's climate including:
Temperature readings
Humidity readings
Money saved
Litres of moisture extracted from the home
We use Avon Electric Ventilation Systems. Click to view Avon Electric's latest product range.


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The senior associate director of basketball operations for the Atlantic Coast Conference acknowledged Sunday night that a mistake was made with the change of the possession arrow during the second half of Saturday's Maryland-Duke game at Cameron Indoor Stadium that gave the Blue Devils the ball on a key possession when it should have belonged to the Terps.
"A miscommunication occurred between the officials and the table crew at last night's Maryland at Duke game," Karl Hicks said in a statement released by the league. "The administrative error happened in the second half at the 16:58 mark when a jump ball was not registered, which resulted in Duke receiving consecutive possessions. The matter has been and will be handled internally by the league office."
The subsequent jump ball occurred with 6:39 remaining in the game. On the ensuing inbounds play, Duke center Amile Jefferson scored on a layup to tie the game at 56. The Blue Devils went on to beat the Terps, 69-67, scoring the game's final five points and watching a last-second jump hook by Maryland's Charles Mitchell hit the back rim and roll off the front rim with the Terps trailing by a point.
League spokeswoman Amy Yakola said Sunday night that the outcome of the game could not be changed as a result of the error.
Maryland coach Mark Turgeon did not mention the incident in his postgame news conference and could not be reached for comment Sunday night.


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Read the November newsletter for the latest information on upcoming activities including yoga and our annual awards banquet! The newsletter also includes rally dates for 2015 and the list of club officers for 2015. Thank you to all of our parents and volunteers who served as officers for 2014!
Click on this post to get a link to the newsletter.


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After becoming unresponsive to e-mails and suddenly disappearing from view, it has been confirmed that Dr. Franklin Ruehl, host of Mysteries from Beyond the Other Dominion, has passed away. Several of Dr. Ruehl's Facebook friends have been openly wondering what happened to him, as nobody seemed to know his wherabouts since November of last year. One of the friends stated that he spoke with Dr. Ruehl's apartment building property manager and confirmed his passing.
Since my friend Mike Barnum could not find any information about his passing in the indexes and registries he has access to, I decided to call the apartment management myself, based on the information provided in the Facebook message. The individual I spoke with confirmed that Dr. Ruehl passed away in November (to the best of his recollection) and that it was a natural death.
In the fall of 1993, I discovered Mysteries from Beyond the Other Dominion on the Sci-Fi Channel. What the program lacked in production values, it more than made up for in heart and can-do spirit. The topics were sometimes silly, but Dr. Ruehl always gave them their day in court, and that's what made the show so special. Without Dr. Ruehl, it simply would not have stood out.
By about the summer of 1994, Mysteries was no longer a part of the Sci-Fi Channel lineup, and aside from the tapes I made of the show, it became a pleasant memory. Many years later, I reached out to Dr. Ruehl via e-mail, and he turned out to be very welcoming to his fans. In the fall of 2010, I made an appointment to visit him in Los Angeles, and we recorded a brief video interview. We touched on Mysteries from Beyond the Other Dominion as well as his interest in Japanese monster movies. The interview is below. (As Dr. Ruehl would say, "Roll tape!")
After I moved to Japan, Dr. Ruehl and I remained in contact. I always enjoyed getting a like or a comment on Facebook from him on my various activities. He was a genuine person, and I'll miss him.
If and when more information becomes available, I will share it here.
Rest in peace, Dr. Ruehl. The power of the cosmos will always be with you.