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|Daniela Hutanu1#, Mark D Frishberg1, Lihong Guo1 and Costel C Darie2*
|1JenKem Technology USA, Plano, TX-75024, USA
|2Clarkson University, Potsdam, NY-13699, USA
|#This author also equally contributed
|Corresponding Author :
|Costel C Darie
Biochemistry and Proteomics Group
Department of Chemistry and Biomolecular Science
Clarkson University, 8 Clarkson Avenue
Potsdam, NY 13699-5810, USA
Tel: 315-268-7763
Fax: 315-268-6610
E-mail: [email protected]
|Received July 21, 2014; Accepted August 22, 2014; Published August 26, 2014
|Citation: Hutanu D, Frishberg MD, Guo L, Darie CC (2014) Recent Applications of Polyethylene Glycols (PEGs) and PEG Derivatives. Mod Chem appl 2:132. doi: 10.4172/2329-6798.1000132
|Copyright: © 2014 Hutanu D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Numerous applications of polyethylene glycol derived polymers (PEGs) have been reported in the scientific literature for many years. With increasing experience and comfort by regulatory authorities, worldwide, in the utilization of these materials in drug and medical device applications, their use in a variety of research and development areas is expanding. This review will focus on just the range of applications of PEGs published in the first half of 2014 in the medical device, drug development, and diagnostics areas, including drug delivery, wound healing, cell culture models, and tissue regeneration.
|Polyethylene glycols; Drug development; Drug-release
|Polyethylene glycols (PEGs) are hydrophilic oligomers or polymers synthesized from ethylene oxide, consisting of a repeating unit of – (O – CH2 – CH2) –. PEGs are synthesized in a wide range of molecular weights, referred to as "monodispersed", when there is a defined PEG chain size and molecular weight, or more commonly as "polydispersed" polymers, when there is a Gaussian distribution of chain lengths and molecular weights. The ability to attach a variety of reactive functional groups to the terminal sites of PEG polymers has greatly expanded their benefits. Hetero- and homo-bifunctional PEG derivatives are especially suitable as cross-linking agents or spacers between two chemical entities [1-3], whereas mono-functional PEGs prevent bridging reactions which may otherwise affect the PEGylation of certain compounds with bifunctional PEGs [4-7]. The sterically bulky structure of branched PEGs consisting of linear methoxy PEG chains attached to a central core, i.e., Y-shaped branched PEG derivatives, facilitates the single point attachment to targets [8,9] via a single reactive group. Multiarm PEG derivatives (Figure 1) prepared by ethoxylation of different cores such as pentaerythritol, hexaglycerol, or tripentaerythritol, and incorporation of reactive moieties, are cross-linked easily into threedimensional hydrogel materials [10-14] (Figures 1a-1c).
|The process of PEGylation, the covalent grafting of a PEG derivative onto molecules, improves the water solubility and biocompatibility, especially useful for drug development [15]. PEGylated products require extensive characterization with complex analytical techniques [16-18] to ensure regulatory compliance for medical applications. Bifunctional PEG derivatives are used frequently for the PEGylation of peptides [19-21], proteins [22,23], small molecules like folate, mannose, prodrugs [3,24], oligonucleotides [25], cells [26], nanoparticles and virus particles [23,27-32], and surfaces [33-37]. Multi-arm PEG derivatives are mostly employed in the formation of hydrogels [14,19,38-56] for controlled release of therapeutics; for use in medical devices; regenerative medicine; and in various other applications, including cell culture, wound sealing, and wound healing. Significant advances were made in 2014 by the scientific community in the research and development of novel applications for PEGs. Table 1 summarizes select novel applications of PEGs described in scientific publications in the first half of 2014, while the remainder of the publication highlights just those 2014 PEG applications related to the medical field.
|Applications of Polyethylene Glycols for Cancer Drug Delivery and Targeted Diagnostics
|R&D efforts on novel applications for PEG derivatives, published in the first half of 2014, focus in majority on drug delivery and targeted diagnostics, either via direct PEGylation of therapeutics [2,3,21,62-65]; or via PEG-containing vehicles, such as nanoparticles [64,65], liposomes [59], dendrimers [32,60], or micelles [57,58,61]. Important parameters that influence the bioactivity of the PEGylated drugs include the length of the PEG chain, the PEGylation site, the linker chemistry, and the temperature selected for the PEGylation reaction. For example, heat treatment was shown to improve the bioactivity of C-terminally PEGylated staphylokinases, whereas an amyl linker for a 20 kDa PEG increased significantly the bioactivity of staphylokinases [62]. The PEGylation of proteins is greatly influenced by the solvent used during the conjugation to the PEG. Peng et al. [22] discovered that organic solvents such as DMSO increase the degree of PEGylation, minimize the PEG hydrolysis, and decrease the PEGylation time for hydrophobic proteins such as G-CSF, compared to PEGylation in water phase. Selecting an organic solvent for hydrophobic proteins has the potential to reduce the cost of the reagents and the reaction times, parameters important for PEGylation processes on an industrial scale.
|Among the many improvements brought to therapeutics by PEGylation are the increased water solubility, improved stability, controlled release, extended drug half-life, and an enhanced PK/ PD (pharmacokinetic/pharmacodynamic) profile. PEGylation of therapeutic proteins occurs mainly on the N-terminal group, carbohydrates, sulfhydryl, and the aminoacids Thr, Cys, Asp, Glu Lys, His, Arg, Tyr, and Ser. In the course of the PEGylation of small molecule drugs, a multi-arm polyethylene glycol will bond multiple drug molecules, ensuring a high drug load and an enhanced drugrelease function [15]. As an example, increasing the molecular weight of the iRGD peptide by PEGylation prolonged the macromolecular extravasation and the overall drug penetration into tumors, and improved the pharmacokinetic profile of iRGD as compared to the unmodified peptide [21].
|PEG-containing vehicles for drug delivery such as liposomes [59], dendrimers [60], nanoparticles [64,65], or micelles [57,58,61] are valid alternatives to direct PEGylation of drugs. Mei et al. [59] developed a multistage liposome drug delivery system co-modified with RGD, TAT, a specific ligand and a penetrating peptide, containing a cleavable PEG that increased the stability and circulation time of the liposomes. Liposomes undergo passive extravasation to tumor tissues, where the dual ligands become exposed through controlled exogenous administration of reducing l-cysteine. Subsequently, RGD recognize integrins, commonly overexpressed on malignant tumors, and mediate the internalization in a synergistic effect with TAT, penetrating deep into avascular tumor spheroids. Another type of PEG containing vehicle, a multifunctional dendrimeric carrier was developed by Kong et al. [60] for targeted delivery of the hydrophobic anticancer drug 10-hydroxycamptothecin (10-HCPT). The dendrimers consisted of integrated hydrophobic C12 alkyl chains with polyethylene glycol chains, and c(RGDfK) ligands on the surface. The dendrimer-10- HCPT drug complex exhibited higher drug loading and stability, and increased water solubility when compared to free 10-HCPT drug. The dendrimer-drug complex showed a higher cytotoxicity towards 22RV1 cells that overexpress integrin αvβ3, and a lower cytotoxicity against MCF-7 cells with lower levels of integrin αvβ3, following selective internalization of the complex into carcinoma cells via integrin receptor mediated endocytosis.
|Drug delivery via PEG-modified nanoparticles is described in several 2014 publications. Super paramagnetic iron oxide nanoparticles containing a self-assembled copolymer of reducible polyamidoamine (rPAA) with polyethylene glycol/dodecyl amine on the surface, were employed for Doxorubicin delivery for cancer therapy [30]. For drug delivery, the intercalating area between the alkyl grafts of reducible copolymers and the oleic acid layer on the surface of the nanoparticles stored the hydrophobic drug, while the PEG chains improved the dispersion of the nanoparticles in aqueous environment. The Doxorubicin delivered via these nanoparticles inhibited successfully the growth of xenograft MDA-MB-231 breast tumors in mice. Drug encapsulation in maleimide-polyethyleneglycol- poly(d,l-lactic-coglycolide) particles (PEG-PLGA) was investigated for targeted drug delivery of Cisplatin [2]. The Cisplatin encapsulating particles were produced using a single step electrospray technique, and were further modified with a CD44 monoclonal antibody targeting the counterpart receptor. Cisplatin-encapsulating CD44-PEG-PLGA particles targeted efficiently CD44-overexpressed ovarian cancer cells, and exhibited an increased anti-proliferative ability at normal chemotherapy concentrations, as compared to the free form of Cisplatin. Polyethyleneglycol-poly (l-lactic-co-glycolic acid) nanoparticles were also employed for targeted drug delivery of Paclitaxel [64]. PEG-PLGA nanoparticles functionalized with an iNGR moiety presented the highest accumulation and deepest penetration at glioma sites. Paclitaxel-loaded iNGR-NP showed promising anti-angiogenesis activity and improved survival time for mice with intracranial glioma.
|Micellar drug delivery systems were explored by Xu et al. [63] for delivery of atorvastatin calcium (Ator). Delivery micelles consisted of amphiphilic copolymers of methoxy polyethylene glycol-s-s-vitamin E succinate (PSV). Ator-loaded PSV micelles showed good colloidal stability, high drug loading, and great encapsulation efficiency. The release of the Ator drug into the cytosol was facilitated by detachment of the PEG shell in the presence of high concentration of intracellular glutathione. The Ator-loaded micelles were shown to inhibit significantly the migration and invasion of 4T1 metastatic breast cancer cells. Dual drug delivery coupled with a targeted approach in a polypeptide-based micelle system was accomplished by Song et al. [58]. The micelle was composed of an amphiphilic copolymer prepared by grafting α-tocopherol and polyethylene glycol onto poly(lglutamic acid), while the surface of the micelles was modified with an αvβ3 integrin targeting peptide, c(RGDfK). The incorporation into micelles of two drugs, Docetaxel and Cisplatin, was accomplished via hydrophobic and chelation effects. The drugs co-delivered in micelles showed synergistic cytotoxicity, long circulation time, and enhanced internalization into mouse melanoma (B16F1) cells. Polymeric micelles have also been employed for diagnostic purposes as delivery vehicles for diagnostic reagents. As a first example, Kim et al. [57] developed pH-responsive polymeric micelles loaded with MRI contrast agents for use in cancer diagnostics. Self-assembled micelles made of amphiphilic block copolymers: methoxy polyethylene glycol-b-poly(lhistidine) and methoxy polyethylene glycol-b-poly(l-lactic acid)- diethylenetriaminopentaacetic acid dianhydride-gadolinium chelate, proved stable at physiological pH, but collapsible in acidic conditions due to protonation of imidazole groups. The destabilization of the micelles in the acidic tumoral environment allowed the preferential accumulation of the MRI contrast agent in the tumoral regions, enabling the detection of small tumors within minutes. As a second example, Guo et al. [61] reported the development of PEG-polyaspartamide micelles loaded with a photosensitizer (Ce6) and cyanine dye (Cypate), with a dual role, cancer diagnostics and cancer photo-therapy. Photosensitizerloaded micelles that also integrated a cyanine dye enabled localizing of the tumors via dual photoacoustic/near-infrared fluorescent imaging, and simultaneously induced photothermal damage to cancer cells by sequential synergistic photothermal /photodynamic therapy.
|Applications of Polyethylene Glycol Hydrogels in Wound Healing and Tissue Regeneration
|Another major reported use of polyethylene glycols in 2014 referenced papers is for the development of hydrogels [14,19,38-56]. Among the common uses of PEG hydrogels are the use as adhesives for wound closure, as controlled release matrices for therapeutics, for wound healing, as part of medical devices, and as regenerative medicine tools. A biodegradable cytocompatible bioadhesive hydrogel system was developed by Jeon et al. [47] from on oxidized methacrylated alginate/8-arm polyethylene glycol amine used for culture of human bone marrow-derived mesenchymal stem cells. The swelling behavior, degradation profiles, and storage moduli of the hydrogel bioadhesive were adjusted by varying the degree of oxidation of the alginate. The adhesion level was enhanced on a porcine skin model as compared to commercially available fibrin glue. Another bio-adhesive hydrogel, Catechol-containing 4-armed PEG end-capped with dopamine, was researched by Cencer et al. [55]. Studies on the effect of pH on the rate of intermolecular cross-linking and adhesion to biological substrates allowed the identification of the optimal buffering pH for formulation of the adhesive. When tested as an adhesive for pericardium tissues, a formulation pH of 7.4 provided the ideal balance of curing rate, mechanical properties, and interfacial binding ability for the Catecholcontaining 4-armed PEG hydrogel end-capped with dopamine.
|Progress on research and development of regenerative therapies aided by PEG hydrogel matrices is reported in several 2014 publications. As an example, a study by Frith et al. [39] describes a combination of mesenchymal progenitor cells with a potentially injectable PEG/ hyaluronic acid degradable hydrogel with a covalently bound pentosan polysulphate, that showed promise as therapy for the regeneration of the cartilage tissue. The molecular weight of the polyethylene glycol chains does not have a significant effect on cell division and sulfated glycosaminoglycan production as part of composite hydrogels [46]. Likewise, for regenerative medicine purposes, Hoffman et al. [48] created a "tissue engineered periosteum", utilizing hydrolytically degradable PEG hydrogels to transplant and localize mesenchymal stem cells to allograft surfaces. The approach increased the autograph healing-graft vascularization, the endochondral bone formation, and the biomechanical strength, when compared to untreated allografts. As a drawback, the process of endochondral ossification was delayed compared to untreated allografts, requiring future supplementation of the hydrogels with additives to expedite the ossification process for treatment of critical sized bone defects. Nguyen et al. [44] controlled the in situ osteogenic differentiation of encapsulated stem cells in polyethylene glycol hydrogels by employing localized, and prolonged delivery of siRNA and/or miRNA interfering molecules. Moreover, differentiation of encapsulated human mesenchymal stem cells down the osteogenic lineage was achieved by Hao et al. [14] by in-situ cell culture in a 4 arm PEG hydrogel scaffold, by varying the rate and type of the hydrogel degradation. A 4arm PEG hydrogel was synthesized via a mixed-mode step-and-chain-growth photo-polymerization in visible light, using functionalized 4-arm polyethylene glycol as a backbone macromer, eosin-Y as a photosensitizer, a di-thiol containing molecule as co-initiator/cross-linker, and N-vinylpyrrolidone (NVP) as a gelation accelerator. The gelation kinetics, gel degradation, swelling and stiffness, were dependent on the identity of the functional groups, the identity of the cross-linkers, as well as on the concentration of the cross-linker and NVP.
|Applications of Polyethylene Glycol Hydrogels in Cell Culture and Tissue Models
|PEG and PEG-copolymer hydrogels are practical solutions as scaffolds and have been used for cell culture; for controlled release of therapeutics; and for various other applications, including but not limited to tissue engineering. PEG hydrogels with physiologically relevant matrix elasticities and diffusion distance, fabricated in transwell inserts, were utilized by Gould et al. [38] for cell culture of valvular interstitial cells and valvular endothelial cells. Growth of the cells in the PEG hydrogel matrices has enabled relevant investigations related to aortic valve stenosis initiation and progression. As a replacement to the traditional 2D cell culture techniques for human Pluripotent Stem Cells (hPSCs), Dang et al. [42] proposed polyethylene glycol hydrogels as cell growth scaffolds, with the addition of an immobilized soluble angiopoeitin-1-derived peptide, QHREDGS. The addition of the peptide enabled a dose-dependent increase in the cell adhesion into a well-defined network, simultaneously inhibiting the apoptosis of hPSCs. The morphology of the human bone marrow stromal cells was demonstrated by Farooque et al. [40] to be closer to physiological conditions in 3D PEG tetramethacrylate hydrogels scaffolds, compared to traditional 2D planar conditions. In another application, Daniele et al. [41] developed a bio-synthetic tissue scaffold consisting of an interpenetrating network of gelatin methacrylamide polymerized within a polyethylene glycol framework for the culture of endothelial cells. This tissue model showed extensive cytoplasmic spreading and cellular adhesion, with sustained viability and proliferation for encapsulated and adherent cells.
|Lin et al. [45] developed an orthogonal thiol-ene PEG hydrogel system for cell culture of liver cell lines, Huh7 and HepG2. The hydrogel system was based on a poly(ethylene glycol)-tetra-norbornene macromere, which allowed facile incorporation of bioactive peptides (e.g., fibronectin-derived RGDS) for improved cell–matrix interactions,. According to the authors, this 3D hydrogel system is the first to upregulate the expression of NCTP in encapsulated Huh7 and HepG2 cell lines and the hepatocyte-like polarity, without genetic modification, and without the need for growth factors and chemical additives. The effect of substrate stiffness on the responsiveness of melanoma cells to treatment with a pharmacological inhibitor, PLX4032, was studied by Tokuda [43] on cell cultures on PEG hydrogel. The use of PEG hydrogels revealed stage-dependent responses to PLX4032 that were not detectable in traditional culturing techniques. For example, the researchers have demonstrated that A375 cells' response to treatment does not depend on the stiffness of the tissue; whereas WM35 cells are more dependent on the substrate modulus, displaying increased apoptosis and decreased focal adhesions on the substrate. Zhang [49] determined that larger amounts of ammonia cross linker used in the polymerization of an 8 arm PEG macromere, lead to higher crosslinking density and bulk of hydrogels, an increased surface elasticity and, generally, to smoother surface morphologies. The amount of cross linker is therefore important in the polymerization of PEG-based hydrogels formed by amine-Michael type addition.
|Several noteworthy research papers published in the first half of 2014 were reviewed in detail in this publication, describing the use of polyethylene glycols and PEG hydrogels in cancer diagnostics and drug delivery, wound healing, tissue regeneration, cell culture, and as tissue scaffold models. Other applications of polyethylene glycols reported in early 2014 are summarized briefly in Table 1, including for PEGylation of small and large molecules, such as peptides, proteins, folate, mannose, oligonucleotides; PEGylation of cells, nanoparticles and virus particles; and for surface modification.
|Table 1
|Figure 1
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When did I get so bitter?
It snowed. I really couldn't care. In fact it positively has irritated me that all my friends keep posting OMGZ SNOW YAY HUZZAH HURRAH bulletins on myspace... and that everyone is out playing in the snow. What is the big deal over frozen water? It's not even snow, its just turned to slush....
Worry not
I too hate it
It irritated you
But then you came on here, where there are already 154 threads about the fucking weather, and mentioned it again?
YE GADS. I'm going to chain myself to Conor Oberst's left calf.
Yeah, I really didn't read anything on the boards today
I'm a self serving bastard. And proud. NOW WHO ELSE HATES FUCKING SNOW?

subset: commoncrawl


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Paranormal Thursday is a new feature @Rather barefoot than bookless
In this feature you highlight an author and a book that you really enjoy reading from in the paranormal genre. There are so many great books out there and so many awesome authors. So this is a chance for us all to recommend some books and authors to eachother that we really like.
I hope you will like this feature and if you like to join in with a recommendation. Leave a comment and/or the url to your own blog post.
This week I thought I would highlight Anna Banks. She is the author of the Of Poseidon series.
I read the first book a while ago and I was pleasently surprised and ended giving it 5 stars of 5.
Galen is the prince of the Syrena, sent to land to find a girl he's heard can communicate with fish. Emma is on vacation at the beach. When she runs into Galen — literally, ouch! — both teens sense a connection. But it will take several encounters, including a deadly one with a shark, for Galen to be convinced of Emma's gifts. Now, if he can only convince Emma that she holds the key to his kingdom . . .
Told from both Emma and Galen's points of view, here is a fish-out-of-water story that sparkles with intrigue, humor, and waves of romance.


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Medical questions & health advice by board certified doctors
"Is humidity bad for a person's lungs?"
I moved to a really humid city this summer and have all kinds of breathing trouble ever since. Can humidity damage your lungs? I'm afraid I have to move because my breathing is all messed up.
If you have not seen your doctor about this issue, you should do so as soon as possible. Any persistent symptoms causing trouble breathing need to be investigated, and I suggest that you start by seeing your primary care doctor. Humidity is frequently associated with worsening of respiratory symptoms, like nasal congestion, cough and wheezing. The reason this occurs is not primary because the humidity directly affects the lungs in most cases. Rather, humidity allows for common allergens, such as mold and mites, to proliferate and fill the air. Since many people with breathing problems have a allergy component, their symptoms will worsen when they are breathing air that is full of these common allergens. Your doctor will be able to perform a complete examination of your lungs and help figure out what is going on. Make sure to mention to them if you have a history of allergies or asthma, as this will help them figure things out. Based on the symptoms they find, they may recommend additional testing (for allergies, for example) or they may proceed directly to prescribing medications to help relieve your symptoms. Get in to see your doctor at your earliest convenience. I hope you are feeling better soon.
Need more info?See a primary care-doctor today
Zocdoc Answers is for general informational purposes only and is not a substitute for professional medical advice. If you think you may have a medical emergency, call your doctor (in the United States) 911 immediately. Always seek the advice of your doctor before starting or changing treatment. Medical professionals who provide responses to health-related questions are intended third party beneficiaries with certain rights under Zocdoc's Terms of Service.


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Doggenheim 10 is a toughy! What really makes it hard is the 2 criss-crossing bulldogs. As soon as the level loads you'll want to use the TV to distract the bulldog on the lower right. Go ahead, start tapping that spot now!
This should let you swerve around the 2 schnauzers after they turn. Pause just a second, then race up and left to get around them, then straight for the disguise. By the way, your first play through you should probably ignore the gem on the bottom right otherwise you'll have to be really quick to snag that and get the disguise before the bulldog is free from his television addiction.
You can pre-emptively open the door at the top during that short pause you did or you can wait till you're safely disguised like I have. Grab the gem and painting and wait up against the top wall until the top bulldog is near a TV.
As long as you haven't waited too long, when the bulldog gets to the top right TV, the schnauzers should be safely away from the center of the screen. Use the top right TV and race down towards the exit!
Here's my score when I ignored the bottom right gem and used no power-ups.
Getting that bottom right gem is a matter of being REALLY fast. It will take a few tries!
Once you have the disguise and at least cat speed 1, and if you're brave, it can last long enough to get you to the exit! Don't wait, just RUN!
Not waiting for the 2nd bulldog to reach the TV, using all my power-ups and grabbing the gem scores me a hot 2295 points. I'm sure I can get that up to 2300 with a few more tries or power-ups!


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Then and now: Torchlight
Then: The first recorded mention of Torchlight notes that on Alumni Day, June 12, 1937, the torch would pass from previous graduates to the president of the class of 1937, who "will then turn the torch, symbol of the spirit of learning, over to the president of the class of 1938 that the flame may remain in the institution," according to a Palladium-Times article. The message of the torch was written by English faculty member Lida Penfield, namesake of the college's library. In 1990, Oswego added a fall torchlight ceremony welcoming incoming students at the start of the academic year. (Photo of 1938 Torchlight courtesy of Penfield Library Special Collections)
Now: This year's Torchlight will feature SUNY Oswego alumna Yvonne Spicer — a leading national advocate of science, technology, engineering and math education — as mistress of ceremonies as alumni from over the decades welcome this year's graduates. Just as Torchlight — which will take place tonight — has passed along the light of knowledge, we have enjoyed the opportunity to share details about our college's rich history throughThen and Now as part of the college's 2011-12 sesquicentennial celebration. We thank you for reading and hope you have found the series educational and entertaining. (James Russell photo)


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Oolong Teas
Oolong teas are halfway between green and black; this gives them the body and complexity of a black tea, but the crisp, bright freshness of a green tea. (It's also halfway in between caffeine-wise.) Folks say our flavored oolong tea blends are some of the best out there!
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Do you have any questions?
+49 (0) 89/ 660 680
Patients and relatives can contact short at this point of contact for questions, suggestions and criticism.
+49 (0) 800/ 660 68 00
We are there for you at the following times
Monday to Friday from 8.00 am to 6.00 pm
Franz-von-Rinecker Straße (main entrance)
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Do you have any questions?
About us
The RINECKER PROTON THERAPY CENTER
The RPTC, located in Munich, is the first fully certified European proton radiation center which provides a complete hospital setting for the treatment of cancer tumors.
Our innovative therapeutic procedure involves the use of high-energy proton beams for the treatment of cancer. A key characteristic of these proton beams is that protons facilitate the three-dimensional targeting of tumours; this capability is not available with the x-rays used in conventional radiation therapy. Therefore, highly effective dosages can be delivered to the tumour while the side effects of radiation are reduced by minimizing any trauma to the surrounding healthy tissue.


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Rory's Martin Guitars
The Martin OM-40 Rory Block Signature Edition
|My signature model guitar is the product of many months of discussions, designs, brainstorming and nit-picking. It is truly the ultimate combination of everything I have always loved and admired about Martin Guitars. We combined the finest materials, classic body shape and size, and added entirely unique ornamentation- particularly on the headstock and fingerboard, where Dick Boak of Martin Guitars and I designed a mother of pearl highway with a train crossing, road signs, and of course my signature. That's a 1930's Hudson Terraplane car on the headstock to celebrate one of my favorite Robert Johnson songs "Terraplane Blues." In addition to the cool yet subtle ornamentation, the guitar has been thoughtfully created for a man or a woman, a rowdy player or a mellow finger picker- all ranges of styles and approaches- from slide, raucous slamming by a blues player's strong hands, to the gentler touch of a finger picker.
To say that I can never properly express my gratitude to the wonderful folks at Martin Guitars- good friend artist rep Dick Boak who gave months of time, energy and artistic brilliance to bring this guitar to life, Ric Forero, head of string marketing, who always came to my area shows and first invited me to endorse my favorite strings, owner C.F. Martin IV for allowing us to create, and the many folks in manufacturing and sales- would be an understatement. I am truly walking on air!
100% of my portion of the proceeds will be donated to the Best Friends Animal Sanctuary. It's only a small contribution to a very large problem; that of neglected, abandoned and abused animals- but every little bit helps.
|The ads for Martin Guitar Strings came out in '97.. (see page 53 of the October '97 issue of Guitar Player). You can't see my face too well, mostly my hair, (so what else is new), but it does say who I am and it is a full page in color. My Martin guitar kicks bootie and since I was using the strings long before they asked me to do the ads, nothing has changed except for the amount of strings in my bus and the new gold strings, which are also too good to be true. The ads appeared in: (1997) Guitar Player: October, Acoustic Guitar: October, Guitar World: September, Fingerstyle Guitar: September/October, Bluegrass Unlimited: August & September, Dirty Linen: August/September, Performing Songwriter: July/August & September/October issues, Music Paper: August/September, etc. There are also display posters in stores picturing Eric Clapton, Rory Block, and Marty Stuart. They say "The best only string with the best." Great company!
Martin Guitars, Nazareth, PA


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Here is mine. I'd have liked to see a much bigger investment made into OLB. I was told that I value OLB too much and that a pass rush isn't all that important and I simply don't agree.1. TJ Watt OLB WI or Tyrus Bowser OLB Houston- IMO, given the depth at CB in this draft, I'd have rather seen us take a edge rusher with the first pick. Both Watt and Bowser are all around OLBs who's best football is in front of them. I don't think we have replacements for either Peppers or Jones on our roster and Perry/ CM3 are 2 of the most injury prone OLBs in the NFL. 2. Ahkello Witherspoon, CB CO - When comparing him to King, their a lot alike. He's every bit as athletic, he's the same height and he's longer. He also played at just as high of a level in the same conference (he was second team PAC12 while King was honorable mention). He lead the country in pass break ups while having one of 5 lowest completion percentages against. If you go back and watch the Pac12 championship, he handled John Ross who's going to be one of the fastest players in the NFL next year. Really smart (pre-med before he got to CO) and coachable kid. Here are objective draft profiles for both players from the same site.https://www.profootballfocus.com/draft-pff-scouting-report-kevin-king-cb-washington/https://www.profootballfocus.com/draft-pff-scouting-report-ahkello-witherspoon-cb-colorado/ 3. Trey Hendrickson OLB Florida Atlantic or Vince Biegel OLB WI- I'd have liked a bigger investment into OLB. I didn't mind the Biegel selection or where they got him but IO don't want to depend on him to play 50-55% of our defensive snaps. Hendrickson was the most productive edge rusher in college football last year. He's explosive off the edge and could turn into a quality pass rusher. He's got work to do in run support though.(Montravious Adams....I liked this pick)4. Desmond King CB/ S Iowa- Here is the replacement for Hyde. One of the best and most instinctive CBs in college football last year. He probably transitions to Safety in the NFL but this is tremendous value. He doesn't have the size or athleticism that Jones has but he was an entirely different caliber of college football player. Not only was he a ball hawk (24 INTs in 3 years) but he was a great return man.(Tarik Cohen......the next Darron Sproles.........kick/punt returner too)5. Aaron Jones RB UTEP- Liked this this Thompson pick. He was a really productive RB who was a big play machine at UTEP.(Ukeme Eligwe, ILB, Georgia Southern.............speedy ILB. Had him in my personal mock) 5. Robert Davis WR, George State- He's got Jeff Janis-esk type of size and athletic ability but he's further along as a WR. 6. Kofi Amichia, C/G South Florida- Another Thompson pick I liked. He's your prototypical Thompson/ McCarthy do everything lineman. 7. Devante Mays, RB Utah State- Another Thompson pick I liked. Here is the banger the offense is missing. The guy who can extend drives and wear down defenses late. 7. Malachi Dupre, WR LSU- Common theme with the above 2 selections. Great value here. He played in a run first offense with a terrible QB. Was once the best WR coming out of high school who's a really good athlete with really solid hands. IMO, he's a better WR than his draft position would indicate. (Hunter Dimick, DE/OLB, Utah..........perfect backup to Nick Perry)
So far...only PackerYakker would have made the same trade down as TT did -- 29 to 33 and get the 1st in the 4th.Others would have stayed put and taken Watt (2) or Foster (1). Interesting.


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Patch 6.1 is dropping this week and Ferals are in for some buffs! Let's have a look. Patch Notes for the PTR are here and MMO Champion has a guide here and a notes here.
Single Target Buffs
Feral single target damage has dropped off as other classes have geared up. Ferals have historically not scaled well with gear increases and often need buffs as the expansion goes on (Savage Roar was buffed to 40% from 30% in Siege of Ogrimmar). To help address this we see some buffs to Ferocious Bite, Shred and Rip.
- Shred damage increased by 20%.
- Rip damage increased by 5%.


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I'm trying to declare classes with the same name. What I have found so far is to use a namespace and put the classes inside.
The problems I'm facing are
1)I do not want the esoteric class to be available but I cannot declare it as Private
2)I want to be able if possible to also name the namespace with the same class name
Declaration:Code:Public Class ValidateMember Inherits ValidateMemberC.ValidateMember End Class Namespace ValidateMemberC ''If possible the name to be ValidateMember Public Class ValidateMember ' I want this to be Private or non visible Public Property UserSessionId As String Public Property MemberPassword As String End Class End Namespace
Code:Dim lv1 As New ValidateMemberC.ValidateMember ' I would like this to be like Dim lv1 As New ValidateMember.ValidateMember Dim v As New ValidateMember ' I do not want this to show


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The ABCs of Death
H is for Hey Everybody, It's S is for SOABCast!
This week, we take a look at the fairly recent anthology horror movie, The ABCs Of Death.
26 letters of the Alphabet. 26 directors. 26 casts and crew. 26 short films. Like around 10 that are good. The rest are either ridiculous, gross, confusing, or have a "Mr. Hankey"-esque character in them.
But it is worth checking out. It was at least a good idea, and there are rumors of a sequel that I hope is better. At the very least, it has short films from the directors of "Timecrimes", and "Hobo With a Shotgun"!
C is for Check it out!
I really need to stop doing that...


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If you're local
If you're local, you know what this building is all about... or at least the rumors. I was more interested in the shadows on the wall.
I got an email this morning from my friend Rebecca who is in design school at Carnegie Mellon. Check out her website http://www.rebeccaaviva.com/
My To Do list for the rest of the day is a mile long, including, but not limited to: taking advantage of the weather and changing the oil on the scooter; finished my taxes; getting my reimbursement for my flight to Chicago sent out; getting Apache, MySQL, PHP and ColdFusion working in harmony on the Mac; and finally resituating the A/C unit in the wall as it looks like it's tilted to the right or something. I'm also supposed to hit the gym somewhere in there... not likely.


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The Inn at Furnace Creek is an attractive cluster of duplex units in a veritable desert oasis.
The Inn at Furnace Creek offers its guests luxury and timeless elegance to modern to rustic guest rooms and suites buttressed up against the mountainside.
The Inn at Furnace Creek has an inn dinning room; a la carte Breakfast, lunch and dinner served in a spacious fine dinning setting; continental fare with an emphasis on regional ingredients and flavorful food pairings. The Inn at Furnace Creek also has an inn lobby bar and an inn pool bar cocktails, specialty drinks, beer & wine, and light lunch fare served poolside.


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Nerd Glasses
Nerd glasses are one of the most widely used kinds of eye has on. The previously mentioned varieties of glasses task an all-time vintage and stylish look, whether it is prescribed or even non prescription ones. These kind of cups are generally must have components for trend fans everywhere across the planet.
There are several things to consider before choosing eye glasses through the store within offline or online moderate. You should ensure to own your vision analyzed from a competent ophthalmologist who will tell you concerning the specific procedures about your eye-sight and will recommend you suitable zoom lens sort along with type. Its also wise to make certain to pick a shape that suits and enhances your face and doesn't tension your eyes. You must choose a shape of better high quality that will fit your look and individuality.


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MajikLand is now hosting a public cluster of Ark: Survival Evolved servers. MajikLand features an Economy based on points from BeyondCheats' Shop, Currency & Kits 1.4 and Arkaley Economy.
PVE Server
Ragnarok is PVE and will never wipe.
PVPVE Server
Aberration has been up since Dec 12th, however it is not very popular. We may wipe it and create a pure The Center PVP Server. Join Discord and voice your opinion!
Weekly Events – Check out the Events Page.
Join Discord for updates!
Join the Steam Group: MajikLand – Ark
Subscribe to the MajikLand Mod Collection for easy joining!
Aberration PVPVE


text: We had a new roof installed in 2000, with Firefree Plus materials by Re-Con Building Products. Despite a 50 warranty, our roof is covered with broken tiles and damage after 12 years. In doing a bit of research, it looks like the company, the product, and the roofing company are now gone. There was an $18.6 million settlement on October 16, 2007 for Firefree Tiles. How and with whom do we file a claim? Thank you so much for any help/information you can provide to us.


text: Admin must be on board with innovation for schools to succeed, Zach Desjerlais says Posted on June 22, 2017 by FETC Desjerlais, named a 2017 CoSN NextGeneration Leader, is a manager of instructional technology for Vancouver, Washington, schools. In just a few years, Desjerlais has seized opportunities and spearheaded innovation in his Pacific Northwest district. Read more at EdScoop


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Freeware Game Pick: Connection Road (D.K)
July 18, 2010 10:00 PM | Tim W.
Connection Road is a Sokoban-style puzzler created by Japanese developer D.K and his friends, where the objective is to collect all diamonds in a stage so that you may progress to the next. You start out with pulling or pushing blocks out of the way, but things get a bit more complicated with the introduction of pipes a few levels in.
Players can walk in or out of pipes quite easily, and you can even push pipes into the water to form a bridge. Solving all thirty-seven stages might sound like a challenge, but it really only takes about an hour or two to beat the entire game. Get Connection Road here. (Windows, 7.25MB)


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Part 1 of 9
What Is Sickle Cell Anemia?
Sickle cell anemia is a genetic disease of the red blood cells (RBCs). Normally RBCs are shaped like a disk. This gives them the flexibility to travel through even the smallest blood vessels. However, in people with sickle cell, the RBCs have an abnormal crescent shape. This makes them sticky and rigid. They can get trapped in small vessels and block blood from reaching different parts of the body. This can cause pain and tissue damage.
Sickle cell anemia is an autosomal recessive condition. You need two copies of the gene to have the disease. If you have only one copy of the gene, you are said to have sickle cell trait. Sickle cell trait explains the geographic distribution of sickle cell disease. It makes you more likely to survive a malaria infection. That's why sickle cell is more common in areas that have, or had, a high prevalence of malaria
Part 2 of 9
What Are the Types of Sickle Cell Disease?
Hemoglobin is the protein in RBCs that carries oxygen. It is made up of two alpha chains and two beta chains. These are made by the alpha and beta genes. The four main types of sickle cell anemia are caused by different mutations in these genes.
Hemoglobin SS Disease
Hemoglobin SS disease is the most common type of sickle cell disease. It occurs when you inherit copies of the hemoglobin S gene from both parents. This forms hemoglobin known as Hb SS.
Hemoglobin SC Disease
Hemoglobin SC disease is the second most common type of sickle cell disease. It occurs when you inherit the Hb C gene from one parent and the Hb S gene from the other. Individuals with Hb SC have similar symptoms to individuals with Hb SS. However, the anemia is less severe.
Hemoglobin SB+ (Beta) Thalassemia
Hemoglobin SB+ (Beta) thalassemia affects beta globin gene production. The size of the red blood cell is reduced because less beta protein is made. If inherited with the Hb S gene, you will have Hemoglobin S Beta thalassemia.
Beta-Zero Thalassemia
Beta-Zero thalassemia is the second type of beta thalassemia. It has similar symptoms to Hb SS anemia. However, sometimes the symptoms of beta-zero thalassemia are more severe. It is associated with a poorer prognosis.
People who only inherit a mutated gene from only one parent are said to have sickle cell trait. They may have no symptoms or reduced symptoms.
Part 3 of 9
Who Is at Risk For Sickle Cell Anemia?
Children are only at risk for sickle cell if both parents carry sickle cell trait.
People from regions that have endemic malaria are more likely to be carriers. This includes people from Africa, India, the Mediterranean, and Saudi Arabia.
Part 4 of 9
What Are the Symptoms of Sickle Cell Anemia?
Symptoms of sickle cell anemia usually show up at a young age. They may appear in babies as early as 4 months old.
Anemia is a shortage of RBCs. Sickle cells are easily broken. This breaking apart of RBCs is called chronic hemolysis. RBCs generally live for about 120 days. Sickle cells live for a maximum of 10 to 20 days.
Hand-foot syndrome
Hand-Foot Syndrome occurs when sickle-shaped RBCs block blood vessels in the hands or feet. This causes the hands and feet to swell. It can also cause leg ulcers. Swollen hands and feet are often the first sign of sickle cell anemia in babies.
Splenic Sequestration
Splenic sequestration is a blockage of the splenic vessels by sickle cells. It causes acute, painful enlargement of the spleen.
Delayed Growth
Delayed growth often occurs in people with sickle cell anemia. Children are generally shorter but regain their height by adulthood. Sexual maturation may also be delayed. This happens because sickle cell RBCs can't supply enough oxygen and nutrients.
Part 5 of 9
What Complications Can Arise from Sickle Cell Anemia?
Sickle cell anemia can cause severe complications. These complications appear when the sickle cells block vessels in different areas of the body. Painful or damaging blockages are called sickle cell crises.
Delayed growth
Neurological complications include fits, bleeding in the brain, or even coma. They are caused by brain blockages. Immediate treatment should be sought.
Blindness is caused by blockages in the vessels supplying the eyes. This can damage the retina.
Skin Ulcers
Skin ulcers in the legs can occur if small vessels there are blocked.
Priapism is a lingering, painful erection that can be seen in some men with sickle cell. This happens when the blood vessels in the penis are blocked. If untreated, it can lead to impotence. Priapism can be treated using ?-adrenergic blocking drugs, analgesia, and hydration.
Gallstones are one complication not caused by a vessel blockage. Instead, they are caused by the break down of RBCs. A byproduct of this breakdown is bilirubin. High levels of bilirubin can lead to gallstones. These are also called pigment stones.
Part 6 of 9
How Is Sickle Cell Anemia Diagnosed?
If you are worried about your newborn baby, genetic testing can screen for the condition before or after birth. Pre-birth testing looks for the sickle cell gene in your amniotic fluid.
In children and adults, one or more of the following procedures may also be used to diagnose sickle cell.
Detailed Patient History
This condition often first appears as acute pain in the hands and feet. Patients may also have:
- severe pain in the bones
- anemia
- painful enlargement of the spleen
- growth problems
- respiratory infections
- ulcers of the legs
- heart problems
If you have any of these symptoms, your doctor may want to test you for sickle cell anemia.
Blood Tests
Several blood tests can be used to look for sickle cell anemia:
- blood counts can reveal an abnormal Hb level in the range of 6 – 8 g/dL
- blood films may show RBCs that appear as irregularly contracted cells
- sickle solubility tests look for the presence of Hb S
Hb Electrophoresis
Hb electrophoresis is always needed to confirm the diagnosis of sickle cell. It measures the different types of hemoglobin in the blood.
Part 7 of 9
How Is Sickle Cell Anemia Treated?
A number of different treatments are available for sickle cell anemia.
Antibiotics like penicillin may be given from 2 months of age to 5 years. They help prevent pneumonia in sickle cell patients.
Pain medication is used to relieve the pain during a sickle crisis. You may need over-the-counter drugs or strong prescription pain medication like morphine.
Hydroxyurea (Droxia, Hydrea) helps to increase production of fetal hemoglobin. It may reduce the number of blood transfusions.
Immunizations can help prevent infections. Patients tend to have lower immunity.
Surgery may be used to treat persistent painful erections.
Bone marrow transplant has been used to treat sickle cell anemia. Children younger than 16 years of age who have severe complications and have a matching donor are the best candidates.
Blood transfusions can also treat sickle cell anemia. Packed red cells are removed from donated blood and given to patients. This improves transport of oxygen and nutrients.
Supplemental oxygen is given through a mask. It makes breathing easier and improves oxygen levels in the blood.
Home Care
There are things you can do at home to help your sickle cell symptoms.
Heating pads and relaxation may help you deal with pain.
Daily supplementation of folic acid and a healthy diet can help you make new RBCs. Fruits, vegetables, and whole-wheat grains are important.
Increased water drinking can reduce chances of a sickle cell crisis.
Avoiding extreme temperatures can also reduce the chance of a crisis. Exercising regularly and reducing stress may help as well.
Support groups can help you deal with this condition. Learn all you can about the disease.
Part 8 of 9
What Are the Long-Term Outcomes of Sickle Cell Disease?
The prognosis of the disease varies. Some patients have frequent and painful sickle cell crises. Others only rarely have attacks.
Recent treatment advances have prolonged and improved the quality of life for sickle cell patients. According to statistics published by the University of Maryland Medical Center, the average life span for people with sickle cell anemia has risen from 14 years to 50 years since 1973. Women have a higher average life span than men.
Part 9 of 9
How Can Sickle Cell Anemia be Prevented?
Sickle cell anemia is an inherited disease. If you are worried that you might be a carrier, talk to a genetic counselor. This can help you understand possible treatments, preventive measures, and reproductive options.


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After arriving to work one recent Saturday morning, Benjamin Sharp was unexpectedly sent home and given a number to call on the following Monday. Sharp, 19, was working stocking shelves at the Erie King Soopers, which was the "perfect job," according to his mother Coleen.
Benjamin has been living with cerebral palsy and certain learning and developmental disabilities.
"He has had some trouble with his legs, but nothing that prevented him from doing his job," Coleen said.
Coleen proceeded to call the number that Benjamin had been provided. It was at this point that the family was informed that Benjamin had been fired from his job at King Soopers due to a positive drug test for cocaine.
She describes her son as "someone who is OCD about what goes into his body." Both were completely baffled by the information.
Benjamin had been given a saliva cheek swab on April 24 by an employee at the Erie King Soopers where he was working. The test had occurred after a week and a half of paid job training.
Neither the store manager nor King Soopers public relations responded to inquires regarding how many people are tested on a daily basis at the Erie King Soopers, or whether the hiring manager wears gloves while conducting a cheek swab. Additionally, King Soopers will not clarify how drug test samples are stored and kept separate, or to what labs they are transported, or how they are transported. Also unanswered is how many recently-hired or prospective employees were tested at the new store on April 24, the same day Benjamin was tested.
"At King Soopers, we support a drug free work environment where all applicants will do drug testing as a condition of employment. Any applicant who has a positive drug test or who refuses to be tested is not eligible for hire," said Kelli McGannon, Director of Public Affairs for King Soopers in an email statement.
"Let me be very clear, Benjamin didn't even know what cocaine was. This is a child who was only homeschooled, whose only friends are his brothers, who doesn't leave the house without myself or my husband," Coleen wrote in an email. "He is a Christian raised in the church who has a strong sense of right and wrong. He's never used drugs in his life, not even marijuana, unlike most Colorado children his age. And we found out the test was wrong. He really didn't know what cocaine was or how it's taken."
She emphasized that Benjamin's best friends are his brothers, and vice versa.
The Sharp family was told that they could have the original sample retested at their own expense. After considering that option, the Sharps decided to retest the original sample. However, it was beyond the two- to three-day window that the sample would still have been viable.
After reaching dead-ends with General Information Services, a background check service, and a medical review officer from Alere eScreen — both contractors for King Soopers — Coleen decided to advocate for her disabled son regarding what the family firmly believes is a case of a carelessly handled drug test..
She got in contact with the family's attorney who advised them to have Benjamin get tested by an independent lab. Benjamin and Coleen traveled to an independent lab on May 24. At that lab, a hair sample was taken from Benjamin. The test came back negative for cocaine and other illicit substances.
A cheek swab typically will show drugs that were ingested within the previous 24 to 48 hours. A hair sample will reflect drugs in a person's system up to 90 days prior to the test.
Due to his conditions, Benjamin has been taking prescription medications. According to Cheryl, a medical review officer at Alere eScreen, no prescription medication should show a positive for cocaine on a drug test. Employees of Alere eScreen do not provide their last names.
Still searching for answers, Coleen began doing her own research and found that certain kidney issues could cause a drug test to show positive. As Benjamin has had kidney issues in the past, Coleen took him to the family doctor where the family was assured that Benjamin was healthy and that there was not anything that should have caused a positive test.
There are only two known substances that could provide a false positive for cocaine on a drug test — coca leaf tea and cocaine-based topical anesthetics. The substance Novocain also has been rumored to give positives, but that theory is debunked by experts.
"If benzoylecgonine, the main metabolite of cocaine is detected, the subject cannot claim that the result is a false positive due to Novocaine administration, or any other "-caine" drug," according to an article on Drugs.com. "Benzoylecgonine is only found in nature as a metabolite of cocaine, and there would be no other valid reason for its presence in a drug screen."
Benjamin had not had any had any Novocain-based dental work done for several months.
Benjamin and Coleen have tried multiple times to get into contact with King Soopers having no response from calls, emails, or letters. So far, they are avoiding legal measures as Coleen does not feel that it should be necessary.
"King Soopers makes the process so difficult, most people probably give up and walk away, but my husband and I refuse and will fight for our son," Coleen said in an email. "We are spending money on this because we know beyond a shadow of a doubt that our son has never touched cocaine, or any drug. And the hair test shows him negative for all drugs.
"We just want our son to get his job back," Coleen said, expressing that she feels they deserve justice.


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Six Challenges That Keep CIOs, Other IT Pros Up at Night
Six Challenges That Keep CIOs, Other IT Pros Up at Night
by Darryl K. Taft
Security Plans Aren't Strict Enough
The growing frequency of reported data breaches and the complexity of attack vectors have pushed security to the top of CIOs' list of concerns. More than half of survey respondents (51 percent) believe security planning should be the last item to receive budget cuts. They report the most common security threats facing their organization are vulnerable Web apps, out-of-date security patches and failure to encrypt sensitive data. Furthermore, 60 percent of respondents said that if they were in charge of their organization's security, they would enforce stricter security policies.
Employee Ignorance Puts Companies at Risk
Respondents identified a lack of security education among their colleagues as a top threat. Nearly two-thirds of the survey respondents (62 percent) said leaving company-issued mobile phones or laptops in vulnerable places is the top employee behavior that poses a security threat, followed by password sharing.
Weak Passwords Provide Easy Access Points
Password hygiene concerns also are keeping IT professionals up at night. Survey respondents reported adjacent letter combinations, a single password for multiple applications and users' failure to change passwords frequently as top threats.
Avoiding Downtime
Two-in-five respondents (42 percent) consider the testing of disaster-recovery plans vital and also among the last line items that should be cut from 2015 IT budgets. Yet when asked which IT vendor is the most undervalued by their organization, disaster-recovery vendors ranked the highest.
Ensuring Security Incidents Don't Become Resiliency Issues
The average cost of downtime to companies is $686,000 per hour. Yet companies that adopt strong resiliency plans can expect 90 percent less downtime per event compared with the industry average. Companies that test their disaster-recovery plans regularly can reduce downtime by 75 percent.
The Need for Top Talent
One out of two survey respondents believe IT talent gets overlooked. Talent acquisition ranked higher than any other overlooked issue, including data center expansion, shadow IT and others.


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"We're so excited to have you here!"
"Thank you!"
"Yes, it's always great to have more lay women here with us."
I am a lay woman. That is my label. I've never really thought about it before, but as of yesterday I've been called that twice. Not only that, but I've been heartily welcomed into my Eastern Christian Theological classes because of that. Not because of my personality, or my obvious thirst for knowledge and a deepening of my faith, but because of my gender and vocational orientation.*
This would never happen to a man. There is no such thing as "Men's Studies." Whether due to historical tradition or patriarchal hierarchies, a man** is always the default setting, the norm, and anything outside that (i.e. a woman) is abnormal and therefore solicited. In this case, I am praised for having chosen to study a subject that, like many, is chalk-full of the male perspective, no doubt so I can chime in with my (supposedly) opposite, female perspective.
This begs the question, "What if my views aren't any different from a man's?" Does that all of a sudden make my opinion any less female and relevant? Of course not! Because my opinion comes from me, it is automatically a female perspective (see Always' "#LikeAGirl" video to see what I mean).
That seems like a lot of pressure, to be welcomed into an area of study because of one's gender and vocational orientation, almost as if one is a mythical creature. Because the truth is, I am just like any man, lay or otherwise, who comes to study the same subject. We all come because of an itch, of that thirst to know more, to have a deeper understanding of things we can never fully know. Yes, the product of our studies may be different, but our faith and scholastic journeys are the same. We're all going to the same place, whether we're female, male, religious, or lay. So why does the distinction need to be made here and now if in the end it doesn't really matter?
Food for thought. Your turn.
Joyanne 😀
*Not true for all of my classes, but I'm simply making a point.
**If I'm being completely accurate, I should say a white, straight man is the default setting, but since I'm only discussing gender, I thought I'd stick just with men in general.


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About Armstrong
Professor Wins Award From the Georgia Speech-Language-Hearing Association
(Feb. 18, 2014) — Armstrong Atlantic State University professor Jean Neils-Strunjas, Ph.D., CCC-SP, was recently presented with the John (Jack) C. Bess Memorial Award for service to the Georgia Speech-Language-Hearing Association. Neils-Strunjas, a professor of communication sciences and disorders in Armstrong's Department of Rehabilitation Sciences, was recognized at a special reception in Atlanta on February 7.
The award was presented in honor of John C. Bess, a successful researcher, clinical audiologist and devoted public servant. The Georgia Speech-Language-Hearing Association established the award to honor like-minded individuals.
"It's truly an honor to be recognized by my peers for this award," she said. "I'm grateful for the collegiality of the members of the Georgia Speech-Language-Hearing Association and the opportunity to work with such talented professionals across Georgia."
Neils-Strunjas donated the award's honorarium to the Mark R. Finlay Visiting Lecture Series fund at Armstrong, which was created in memory of an Armstrong History professor known for his scholarship, his contributions to the State of Georgia and his integrity.
An accomplished faculty member, Neils-Strunjas originally joined Armstrong in 2011 after serving as a professor and director of graduate studies in communication sciences and disorders at the University of Cincinnati. She and the faculty of the Department of Communication Sciences and Disorders at Armstrong educate and supervise graduate students who provide speech, language and hearing services at the Rite Care Center for Communication Disorders. The Center offers reduced cost and free services to the university and the greater Savannah community.


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UKIPT Nottingham: Day 1B, level 1 & 2 updates (blinds 50-100)
2.05pm: End of level
It's the first 15-minute break of the day. Just another nine levels left to play. -- RD
2pm: Freerollin'
Chris Brammer finished Season 1 at the top of the UKIPT Leaderboard and won entries into all nine UKIPT events this season. That's quite some freeroll. He's currently on around 9,000, not the best of starts, but the young Brit has plenty of time to make yet another deep run here in Nottingham. -- RD
1.55pm: Pyefinch finished
Suzanne Pyefinch first came to our attention at UKIPT Edinburgh in August where she final tabled and told us that a friend of hers had a premonition that she would win but would have to lay down pocket aces heads up. In the end she finished seventh for £6,300. She'll have to wait until Manchester to try and make her second UKIPT final table as she's one of 15 players to have exited the tournament so far today. -- NW
1.45pm: Ainsworth straight up the chip charts
Team PokerStars Pro Jude Ainsworth has near doubled his stack in the opening 90 minutes and has around 27,000. He filled us in on the key hand that boosted his stack:
"There were two limpers and seat two (Julian Lefevre) made it 500 to go, I made it 1,300 with [4][5] and he called. The flop was [A][2][2] he checked, I bet, he called. The turn was a [4] and it went check, check. The [3] on the river gave me a straight and he check-called a bet of 3,500 with pocket kings. -- NW
1.40pm: Ulliott x-rated action
Dave 'Devilfish' Ulliott isn't shy. He's pretty far from that to be honest. So when our Channel 4 camera crew swung by his table to look into the fish bowl Ullitott was more than happy to put on a performance.
"You trying to film my ring?" asked Ulliott, hinting towards the 'Devil' and 'Fish' gold rings which adorn his right and left hand respectively. He quickly rose to his feet and turned round as if to drop his trousers.
"Yeah, the old ones are the best," said the cameraman, looking quite unimpressed by the whole incident.
"What are you trying to say?" asked Ulliott, perhaps a little too concerned that his derriere might be anything other than pert. -- RD
12.30pm: Nani wins a big pot
Luis Nani has just won a big pot against Manchester City... Hold on, that's not right. Nani has just scored in the Manchester derby for the red half of the city. The screen that we were looking at yesterday for the tournament clock has been switched to the football and it's proving to be quite distracting. Back to the poker. -- RD
1.25pm: Due
If this tournament had taken place a month ago I'd be saying that James Keys was in that group of young talented British players who were 'due' and good candidates for that big breakthrough live result. Well lo and behold he struck gold downunder winning just over a million Australian dollars (£626,000) in January. Last night was his celebration party and a heavy night was had in Nottigham: "I've only been back two days it's the first time I've seen everyone," explained Keys. "We went to Hooters, then to town and then I don't remember much!" Despite that Keys seems bright and alert and says of his tournament thus far: "I lost 5,000 then won it back, so no net movement." -- NW
1.12pm: He who dares loses
So said Dan Owston, who is currently watching the Manchester derby from the comfort of the bar, his tournament having come to a premature end after 40 minutes. "I got it in with a open ended straight flush draw against bottom set. He made a house on the turn, thanks very much for coming!" Eight players in total perished during the first level.-- NW
1.10pm: Grafton and the dragon
London-based Sam Grafton went deep in two UKIPT events in season one and always seems to run up a big stack but not quite get the big result. He'll be looking to put that right here in Nottingham. Amongst those hoping to put a dent in his stack early on will be Jeraint 'JJ' Hazan, who is the poker player famous (or should that be infamous) for his appearance on Dragon's Den. -- NW
12.55pm: Calculated Risk
Nick Abou Risk has an incredible UKIPT record. In August last year he won UKIPT Edinburgh for £50,000 and in December he took down the first event of Season 2, the €1,000 Galway main event, for a further €67,000. His other live cash was a £150 deep stack event here at Dusk Till Dawn in June off last year. He won that as well for £7,090. It's a ludicrous showing; three cashes, three wins. -- RD
12.45pm: Quite a spread
Despite the number of well known players in the field the random table draw seems to have spread them far and wide. Table 62 could be one to watch with two players who've made UKIPT final tables Marius Lietuvninkas (6th Coventry), Suzanne Pyefinch (7th Edinbrugh) and Fintan Gavin sharing a table. With the players packed in some tables are hard to access but we'll do our best. -- NW
12.35pm: Players as far as the eye can see
Everywhere you look there are players here and I mean players. Irish legend Liam Flood is sat at the next table to WSOP bracelet winner James Dempsey, who is talking to John Eames, who last year really started converting his online dominance into live success, who is... We could go on and on. And probably will.
That said, these big names only make up a small percentage of the field, the majority of which comprises of players looking to make their name and satellite heroes looking to make a major score. There'll be plenty of beats and banter as we make our way through the day. We're half way through the first level but with blinds at 25-50 and a 15,000 starting stack it should be hard for anyone to go bust. -- RD
12.25pm: Big field, big names
As well as the Devilfish the first sweep of the room has unearthed some familiar UKIPT faces. Last years winner Andrew Couldridge is playing, James Keys - who's a man in form - is also here as are Liam Flood, Marius Lietuvninkas, John Eames and the never- knowingly-quiet Dan Owston. Keep an eye on the chipcounts page where we'll be keeping track of the notables and big stacks. --NW
12.15pm: The fish is in the house
Dave 'Devilfish' Ulliott is here, ladies and gentlemen. This event has truly brought out all the biggest names in British and Irish poker. Forget EPT London (okay, don't actually forget EPT London) but this event could crown the true UK and Ireland champion. Jude Ainsworth for one will be looking to take this title back across the Irish sea. -- RD
12.05pm: The clock is running
The tournament room looks fantastic again today and is packed to the rafters with Brtitish poker talent. We have, among others,Team PokerStars Pros Vicky Coren and Jude Ainsworth, EPT winner Jake Cody, Jeff Kimber, Irish Open James Mitchell, Chris Brammer and double UKIPT winner Nick Abou Risk. Chip counts of the named, notables and big stacks will be posted in our chip count section throughout the day. -- RD
11.50pm: Record breakers
Day 1B is set to complete a record field here at the Dusk Till Dawn poker club in Nottingham. We had 478 runners yesterday, 100 of which made it through, and the Day 1B field looks strong to tip the combined field over the 1,000 player mark. -- RD
PokerStars Blog reporting team in Nottingham (in order of direction shouted at a junction before getting lost on way to DTD): Rick Dacey (Left!) and Nick Wright (Right, right, right).


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Android and iTunes app for Birmingham available now!
Tag: advertising
Example Post for Advertisers
This lovely, leafy 13km (8 mile) circular walk takes you into one of the most popular and sought after suburbs of Birmingham to live in, Harborne. You will walk along leafy lanes, canal towpaths, past Michelin star restaurants, Botanical Gardens, the lively Harborne high street and even country style pubs just a stone's throw from the city centre! Continue reading "Example Post for Advertisers"


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Audrey Fogelman from Rutland had this to say about Quantum in the Guardian on 27th December:
'As a fairly innumerate non-scientist, I am perversely drawn to books about maths and science and usually abandon them with ignorance intact. However, Quantum by Manjit Kumar (Icon) is so well written that I now feel I've more or less got particle physics sussed. Quantum transcends genre - it is historical, scientific, biographical, philosophical.'
The full article is here.


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I remember being around aged sixteen, at college, with my own money for the first time, standing in the likes of Topshop and H&M and being completely lost looking at all these clothes in front of me. They were all beautiful and I remember seeing some of the stuff on people like Zoella, but ultimately, I would regularly walk out empty handed. Or, polar opposite, I would walk out with five or six pieces, all of which I'd wear once and never again. I guess I just never knew what my personal style was.
At aged 20, I now have a pretty good idea of what my style is; simple but with stand out, statement accents. I can walk into Topshop and H&M and know exactly what I like and what I don't. I have more of an idea of what suits me, what looks good, what I feel comfortable in. All important qualities when it comes to creating and building your wardrobe. So today, I thought I would offer my advice on finding your own personal style.
01. Clean Out Your Closet
When it comes to working out your style, it's a good idea to look at what you already own. Open up those closet doors and go through your wardrobe. Take each piece of clothing and work out when the last time you wore it was, if you wear it often, if you feel confident in it and if you actually like it. Do you like the cut? The material? How it sits on your body. If you've answered yes to all those questions, you've got yourself a piece you very obviously love and therefore you should keep. Edit out the pieces that perhaps you've realised you've only worn twice, that you don't actually like all that much or doesn't suit you. Just by doing this you'll start to see a pattern and start to get a good idea of what works for you and that's what you should stick with.
02. Find your Style Guru
When flicking through magazines, who's style do you find yourself thinking 'oooh, that looks good' or 'I always love what they're wearing'? This is one of the first questions to ask yourself when it comes to finding your style. Find a celebrity or blogger who's style you admire or like and see if you can find any statement pieces that they regularly wear that you love. For example, my style icon is Gigi Hadid. I love her effortless, simple style and how she focuses on one key concept every outfit whether that be one colour or a statement accessory, such as shoes.
03. Create a scrapbook/pin board.
Again, just like finding your style guru, grab your tablet or your laptop and get onto Pinterest. Browse the fashion boards and have a look at all the different styles you'll see. Create a 'style inspiration' board (you can see mine here!) and pin all the images of the styles you like in there. Pin the styles that you could see yourself wearing and want to re-create. You can keep adding and removing pictures from this over time to keep constantly it updated with what you're loving at the moment. My tip? Before you go out shopping or before you do an online shop, have a look at the board, give yourself last minute inspiration before you spurge, which helps to keep your mind (and your balance) in track with the hope that you'll end up only buying what's in your style. For example, the top I'm wearing in this post? I saw Kendall Jenner (another style babe!) wearing something similar, which I loved, so when I saw this on ASOS, I happily brought it and I'm obsessed with it!
05. Jazz it up!
Once you've started to 'get' your own style and you're starting to see what you love, it's time to jazz it up with some statement accessories that you can pair with more than one outfit. For example, take these sunglasses I'm wearing in this post. The reflective rainbow makes them a pretty statement piece but because my wardrobe is mainly monotone or grey or nude, these goes with pretty much everything. Other statement pieces could be a watch, find one you're completely in love with, find one that will go with several outfits and you've got yourself a winner. Jewellery, bags and even shoes all count, find that perfect piece. Buy that perfect piece and go out and adore that perfect piece.
06. You're Your Best Judgement.
Finally, the last puzzle piece in the jigsaw of finding your own personal style is you. You are you're own best judgement. It's so important to stay authentic and be true to yourself. If your style icon is wearing a bomber jacket and you don't like bomber jackets, don't buy one just because you feel you have to because they're wearing and loving it. Want ripped jeans but your best friend don't like them? Buy them! Buy and wear what you want to wear, what makes you feel a million dollars, what makes you want to strut down you're own personal runway Victoria Secret style. Experiment with different styles and accessories until you find that 'one' piece that you just can't get enough of. Stay true to your taste and you do you, use fashion as a way to express yourself and you'll never get it wrong.
Outfit Deets: Top: ASOS / Jeans: Bershka / Shoes: Primark / Bag: Zara


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Another room has displays that illustrate aspects of different cultures around the world.
Thank you Tricky for hosting.
Such a gorgeous gold crane on the Kimono.I enjoyed the photo to enjoy it much more!
I like those benches and glad you showed the close up of the tiles. could not tell it was tiles in the whole shot of the curved benches. that is really a great butterfly project.. really creative use of recycle goods..ReplyDelete
Always enjoy a good museum trip, how interesting the children's project was and wasn't that a gorgeous kimono.ReplyDelete
Love the mosaic benches they are very attractive and make the area so much more interesting for the visiting children.ReplyDelete
LOVE the butterfly in the children's project! And that Japanese kimono...wow! Beautiful museum...even the benches are lovely!ReplyDelete
So much wonderful detail in the mosaic benches. I always enjoy places more when they have hands on exhibits, must be the kid in me. Interesting butterfly.ReplyDelete
What a wonderful museum with so much to admire. The benches were a particular delight.ReplyDelete
It looks like an interesting museum. I love the mosaic benches, what a wonderful place to have almost on your doorstep:)ReplyDelete
If I was in Sheffield, I'd be in the Museum like a shot! It's amazing what you can find inside. Have a good weekend. 🌼🌼🌼🌼🌼ReplyDelete
It is so much to admire in this museum. The children's project ist great.
I wish you a nice weekend
Simply loved the mosaic and the butterfly in the children's project - it really looked so colourful.
All the best Jan
I'd love a trip to that museum. That beautiful kimono - breathtaking. And the sky was so pretty that day.ReplyDelete
What a wonderful trip as shown by the lovely photos, thanks for sharing!ReplyDelete
So many beautiful displays....Love the kimono and mosaics! x KarenReplyDelete
Wow....loved it all, especially the kids butterfly, amazing!xxxReplyDelete


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King Charles – LoveBlood
Today see's a return to yet another old favourite. Maybe there's something inherent in nostalgia that's somewhat secure and comforting, or perhaps it just so happens that there's a string of upcoming releases that we've been eagerly anticipating for a while now, probably the latter. Truth be told I'm not even sure if 2010 can qualify as nostalgic, that's when we first featured King Charles, with his cover of Billy Joel's "We Didn't Start The Fire" appearing in our Songs Of 2010. Either way the good news is that his debut album "LoveBlood" is set for release on the 7th May and today we've the lead single for you.
There's something invariably poppy about King Charles, the fact that that could be in anyway be construed as a bad thing speaks volumes for how pop has been ripped from it's true roots. The essence of popular music is simply that it has universal appeal, and yet at the same time that is what makes it so fickle and subjective. I would however challenge anyone to listen to "LoveBlood" without it nestling away firmly in their subconscious. From the quirky guitar riffs reminiscent of Vampire Weekend to the vocal texture that is very much King Charles' own this is pop music as it should be, refreshing, uplifting and infectious.
It will be interesting to hear how King Charles' sound pans out across the rest of the album, inevitably his distinctive vocals will dominate but it will surely be the way in which he manages to meld instrumentation and rhythms around them whilst maintaining a breadth and cogency of sound that will define the LP. With a track list featuring the likes of "Love Lust", all anthemic chanting and hectic, soaring crescendos, and "Ivory Road" which displays a subtler lyricism amid a healthy dose of hand clapping, things are looking pretty promising. Check back here nearer the time for an update; in the meantime enjoy the video below.


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Benefits of Eco-Friendly Pest Extermination in the City
If you and your loved ones are currently living in the city, it is not uncommon to deal with pests from time to time. The issue with living in the city is that a neighbor's pest control problem often will become your pest control problem because of the vicinity of the two homes. Instead of resorting to chemicals and companies that use extensive bombs and deterrents, it might be time to think about the benefits of using pest control in the city without needing to go chemical products that are available to you in the local store.
One of the main benefits that comes with more eco-friendly solutions is that you're not using harmful chemicals around the home. If you have chemicals being used in the home to get rid of a pest, you may be told to leave the house or at least bring pets and small children out for a few hours or even a few days. It's not comfortable using these methods because they can be a bit invasive, so using better quality and greener products is definitely the way that you will want to go when it comes to the safety of the home.
Many companies are also now using Eco-friendly pest extermination in the city for those who want to avoid chemical products. If you are choosing to work with a company, it's important you tell them that you only want natural and Eco-friendly products used so that you do not have to deal with heavy chemicals. Having a better solution for yourself is the first step to ridding the home of pests without the problems that come with chemical products. This is a solution that you will benefit from for many years to come, even if you choose to use it again in the future.
Posted by Bob on Fri, 26 Sep 2014


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We're down to the wire, folks. Not just in terms of the 2012 calendar. Or the fiscal cliff talks. But the opportunity for you to target gains of 26.8%, 55.1%, and 59.5% from the ongoing global banking crisis.
Look, you and I have both heard lots of happy talk about how the global banking sector is improving. But it's just that. Talk. Because the numbers tell a dramatically different story!
A whopping 464 banks with combined assets of $680.3 billion have ALREADY failed. That's in the U.S. alone, since 2008. But according to my colleagues at Weiss Ratings, ANOTHER 202 global banks — with assets of a whopping $43.6 trillion — are at risk, with ratings in the two lowest tiers.
Meanwhile, the fallout from multiple regulatory investigations keeps piling up!
* Swiss giant UBS just agreed to pay a whopping $1.5 billion fine, equal to one-third of the profit it made in 2011! The company was accused of rigging the fixings for LIBOR. That's a key global benchmark rate that determines what mortgage borrowers and corporations the world over pay on certain loans!
* Barclays of the U.K. also got nailed in the global regulatory sweep, agreeing to pay $472 million in June!
* Meanwhile, behemoth Deutsche Bank of Germany and its executives are being investigated for tax evasion, obstruction of justice, accounting manipulation tied to derivatives, and more!
Now you can rest assured that the "Big Three" ratings agencies — Moody's, S&P, and Fitch — are not going to warn you, accurately and in advance, of big trouble at these kinds of institutions. After all, they've missed virtually every major crisis in the past couple of decades!
They gave Enron investment grade ratings until just a few days before the company went broke. They also blessed tons of lousy mortgage bonds with "AAA" ratings in the mid-to-late-2000s. Those bonds ultimately left investors and banks with hundreds of billions of dollars in losses!
What you need is accurate, unbiased information and bank ratings, and a game plan to navigate these crises. The good news? I have that for you — all the details on the massive profit opportunities available to you as the global banking problems I've outlined come home to roost.
Here's …


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Monday, 22 December 2014
Peanut Butter Cranberry Bars & Take-Off
In this case, I managed to behave, just in time to make these lovely nutty bars! These are sugar-free, vegan, and packed full of nutty goodness, just the way we like it!
Peanut Butter Cranberry Bars
(Makes 4-6)
1 cup dates
2 tbsp dried cranberries
2 biiiig tbsp peanut butter
1/2 cup oats
50g hazelnuts (or other nuts)
- Simply soak the dates in a bowl in warm water for five minutes, then drain. Add all the ingredients to a food processor and blend until you have a sticky paste, still with a bit of crunch to it.
- Take a small cake tin or a bread tin, and dress it with clingfilm, then add your mixture. Flatten down into the tin firmly with your hands. The mixture should be about 1cm thick.
- Now, you can cut them into little bars, OR you can make power balls, simply by rolling them.
These are perfect for lunchboxes, when you're in a hurry and need something on-the-go, or enjoy with a cup of coffee in the morning or afternoon.
PS. I am pretty sure my stick blender hates me.... In fact, I know so, he's giving me evil looks and wants to retire in place of an actual food processor...
What are your favourite bars?
On a slightly different note, this will be my last post before christmas! I am going to Norway today (cannot wait!) and because I am only there for five days, I doubt I will be online much during that time, as I have soo many lovely faces to see! So don't you go posting hundreds of goodies in my absense! (Although, I will probably scroll back and update my self even if it will take me a week...).
Bags are packed, Seamus and Finnegan have gotten their holiday fish food and are on their second breakfast, and all I can say is simply have a wonderful festive season! Big hugs from Glasgow x
Original source:
- Jules aka Julienissen
10 comments:
God tur hjem og riktig god jul til deg og dine! Kos deg!!ReplyDelete
Disse høres nydelige ut, og ser skikkelig gode og chewy ut- yum!!
Har dilla på tranebær for tiden, og putter de i salater og sjokolade <3Replies
Tusentusen takk Ragnhild! Kjenner det er på tide med en liten pause og julekos med familien :)Delete
Hahah ja tranebær er virkelig allsidig! Du får prøve deg på disse og se hva du syns :) Jeg trillet kuler av deigen andre gangen jeg laget de ^ ^
Håper du fortsetter julekosen fra i går gjennom hele julen og romjulen :D Så snakkes vi før nyåret <3 x
Have a great vacation! Stay warm up there! :DReplyDeleteReplies
Hey! Thank you so much, I had a lovely time! I hope you have a great time as well :) Norway was lovely and though snow was late (started falling on the evening of the 25th) it was almost a foot of it by the 26th, beautiful :D Safe and sound in Glasgow town now though :) xDelete
you're right -- nothing more disappointing than an empty PB jarReplyDeleteReplies
I know, right?! But thankfully I have topped up on it since, all's well! xDelete
Haha, my method is just grabbing a spoon :) But if I can control myself, I will definitely try this!ReplyDelete
Have fun in Norway!! Not going skiing? Since I'm back in BC, I went skiing and snowshoeing for the past few days. Love the holidays :)Replies
Spoons work too, often too well :P And then...there is no more!Delete
I am actually a terrible skiier, despite rumours that all Norwegians are born with skiis on their feet :P Buuut we did get snow aplenty for the 26th and it was beautiful! :D Whatever is snowshoeing? Guess I have to look that up as soon as! Sounds like a lot of fun though! I hope you have a great New Year's Eve too! x
Kos deg i Norge i jula!ReplyDeleteReplies
Takk skal du ha Maria! Det gjorde jeg vettu! Alt det beste for det nye året :) Stor klem fra xDelete


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MIAMI/SOUTH FLORIDA Design Miami opened to the public Wednesday with work by 170 designers and gallery owners from four continents on display. The event, now in its seventh year, merged historic design with cutting-edge contemporary work, highlighting important pieces of furniture, lighting, and objets d'art from the 20th and 21st centuries.
"Design is the creative discipline that most strongly shapes and impacts the world that surrounds us," said Marianne Goebl, director of Design Miami. "Design is also a discipline that embraces many facets and shapes from the unique, hand-made piece to the machine-made mass production. Design Miami is dedicated to representing the most relevant perspective in the field of collectible design."
For the second year, the international design forum is at home in a 49,000-square-foot custom exhibition venue in a parking lot adjacent to the Art Basel Miami Beach fair, which runs through Sunday at the Miami Beach Convention Center. According to Gobel, this year's Design Miami show grew by 40 percent and 9,000 square feet. First-time participants include Belgium artist Pierre Marie Giraud and Parisian gallery owner Maria Wettergren.
This year's sponsors, Fendi, Audi, and Swarovski, all created striking installations that highlighted light, architecture, and, of course, design. Automotive sponsor Audi teamed up with Danish architect Bjarke Ingels to bring his vision of a "digital street" to life in an interactive, three-dimensional LED installation titled "Urban Future." The display also functioned as the U.S. debut of the A2 e-tron concept car. Swarovski presented "Crystal Matrix II" by Erwin Redl, pairing light and music with solo pedestal displays of illuminated crystals, and Fendi even featured a V.I.P. Collector's Lounge, which mirrored its "Craft Alchemy" design performance gallery. Contemporary artist Sebastian Neeb and designer Elisa Strozyk developed leather furniture sculptures inspired by the brand's Rome headquarters.
London-based architect and designer David Adjaye received the designer of the year award and showcased a larger-than-life wooden installation called "Genesis" at the entrance of the Design Miami pavilion. The wooden structure, made of hundreds of vertical pine planks, created a meditative space at the entrance and introduced visitors to Adjaye's vision.
The event also welcomed back Stefano Tonchi, W magazine's editor in chief. He moderated Design Talks, a series of panel discussions that featured Lord Norman and Lady Elena Foster, designer of the year winner Adjaye, architect Rafael de Cardenas, and Spanish designer and architect Patricia Urquiola.
The Design Miami and Art Basel fairs run through Sunday.


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Contact Us
Thank you for your interest in MAPA. For more information on MAPA, becoming involved or any queries and comments, please use the contact details below.
For projects, prospective partners, workshops and corrections to protected areas:
Alta De Vos: alta[at]mapaproject.org
For general enquiries, or queries related to physical mapping:
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MBS FileMaker Plugin, version 5.0pr9
New in this prerelease of the 5.0 plugins:
- Added Path.FileURLToFilePath and Path.FilePathToFileURL functions.
- Added parameters to DynaPDF.GeneratePreview to query image.
- Trace command now also logs Audit results. Also SQL/Evaluate errors while Audit are written to Console/DebugView.
- Updated DynaPDF to version 184.108.40.206.
- Added Webview.SelectedText function.
- Added Barcode.EANChecksum and Barcode.ISBNChecksum functions.
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After being nominated a record five times for Best Novel, Tana French took home the top prize for The Trespasser, which received rave reviews for blurring the lines between genre and literary fiction. In a statement read by her publicist Ben Petrone, French said: "I am honored and I really wish I were there tonight, and I am relying on Ben Petrone and Andrew [Gulli] to down a couple of my favorite cocktails for me."THE TRESPASSER, of course, also took home the crime gong at last year's Irish Books of the Year bunfight. For all the other winners at the Strand Critics Awards, clickety-click here …
Praise for Declan Burke: "Burke shows again that he's not just a comic genius, but also a fine dramatic writer and storyteller." – Booklist. "Proust meets Chandler over a pint of Guinness." – Spectator. "Among the most memorable books of the year, of any genre." – Sunday Times. "A hardboiled delight." – Guardian. "Imagine Donald Westlake and Richard Stark collaborating on a screwball noir." – Kirkus Reviews. "A cross between Raymond Chandler and Flann O'Brien." – John Banville.
Sunday, July 23, 2017
News: Tana French Wins the Strand Critics Award
Posted by Declan Burke at 11:29 AM


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George VancouverGeorge Vancouver was an English navigator who completed one of the most difficult surveys ever taken, that of the Pacific coast of North America, from the surroundings of San Francisco northward to present-day British Columbia. At that time he proved that no continuous channel exists between the Pacific Ocean and Hudson Bay, in northeast Canada.
George Vancouver was born in King's Lynn, Norfolk, England on June 22, 1757. He was of Dutch ancestry, descended from the titled Van Coeverden family.
George's father, John Jasper Vancouver, was assistant collector of customs at King's Lynn and his mother, Bridget Berners, came from an old county family.
Vancouver entered the history of exploration by joining the Royal Navy at age 13 and accompanied Captain James Cook on his second and third voyages (1772-75 and 1776-80). In December 1791,Vancouver was appointed commander to the expedition to the northwest coast of North America and was given three assignments: first, to meet a Spanish commissioner at Nootka and settle the damage claims start from the 1789 seizures; secondly, to make a detailed survey of the coast from California to Alaska; and, thirdly, to try to determine once and for all whether an entrance to a Northwest Passage (or a navigable passage that extended far inland) actually existed.
Departing from Falmouth, England on April 1, 1791, Vancouver rounded the Cape of Good Hope, and visited Australia, New Zealand, Tahiti and Hawaii. On April 17, 1792, Vancouver sighted the west coast of North America at 39ÃÂú27' N. By that time, he had intended to explore every bay and outlet of this region, and many times had to use boats rather than his ships to do so, because the inlets were often too narrow for his ships. Vancouver also examined the coast with detailed care, surveying the...


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A bicyclist accused of striking and killing a pedestrian in San Francisco's Castro District last year was ordered today to stand trial on a felony vehicular manslaughter charge.
Chris Bucchere, 36, was held to answer to the charge by Superior Court Judge Andrew Cheng after an emotional preliminary hearing that ended this morning.
Prosecutors allege that Bucchere ran multiple red lights and stop signs before striking Sutchi Hui, 71, at Castro and Market streets on the morning of March 29, 2012.
Defense attorney Ted Cassman argued that surveillance video of the collision showed that Bucchere had entered the Castro and Market intersection before the light turned red.
Bucchere broke down in tears at times during this morning's hearing. Both he and Cassman declined to speak to reporters afterward.
Bucchere will return to court to be formally arraigned on the charge on March 21.
Copyright © 2013 by Bay City News, Inc. … republication, re-transmission or reuse without the express written consent of Bay City News, Inc. is prohibited.


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|Nobody got wet! :)
playing with a gyroscope,
|"Slinky, slinky, it's such a wonderful toy..."
In unit 6, we learned about the use of machines by trying to create a structure using toothpicks instead of hands to lift the blocks.
We skipped building research in lesson 31, observing natural machines in lesson 32, and scientist research in lesson 34.
And with that, we finished our summer science. Woo-hoo!
Soprano will have an easier school year which I'm sure she'll enjoy. Tenor will have another science during the year but it doesn't look too intense. We'll see how it goes... we start on Monday!


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Detailed plot synopsis reviews of The Jerky Boys
Script Analysis of The Jerky Boys
Click on a plot link to find similar books!
Plot & ThemesComedy, primarily - Yes Time/era of movie: - 1980's-1999 Kids growing up/acting up? - Yes Kids: - committing crimes Crime & Scandal - Yes Comedy or Parody about - gangsters/crime
Main CharacterIdentity: - Male Profession/status: - unemployed Age: - 20's-30's Ethnicity/Nationality - White American
SettingUnited States - Yes The US: - Northeast City? - Yes City: - New York Misc setting - bar
Writing StyleAccounts of torture and death? - generic/vague references to death/punishment Any profanity? - A lot of foul language If this is a kid's movie... - Ages 10-15
Movies with storylines, themes & endings like The Jerky Boys
|Mickey Blue Eyes starring Hugh Grant, James Caan, Jeanne Tripplehorn
|Analyze This starring Robert De Niro, Billy Crystal, Chazz Palminteri
|Stand Up Guys starring Al Pacino, Christopher Walkin, Alan Arkin
|Running Scared starring Gregory Hines, Billy Crystal, Steven Bauer
|My Blue Heaven starring Steve Martin, Rick Moranis, Joan Cusack


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We still have a few spots available for our Chinese New Year Gathering this Sunday. So if you haven't gotten your tickets, hurry and do so. Join us.
Thursday, January 28, 2016
Wednesday, January 20, 2016
Member Billy Lee Honored at 1990 Institute Gala
Thanks to Billy and Lucille Lee, George Chadwick and I were able to attend the recent 1990 Institute Gala. The Gala was filled with stars from Hollywood (Joan Chen, Russell Wong, and Hudson Yang), from Silicon Valley (Alibaba, Blackberry, etc), and from Washington (Ambassadors Gary Locke, Jon Huntsman, Jr., etc)
But the brightest star was our Billy Lee who was honored that evening for being one of four people to have started the 1990 Institute.
Wednesday, January 6, 2016
Look at Updated Menu!
In response to requests, I've printed the entire menu for our celebration in the new version of our flyer below. Also please note the start time (5pm). We look forward to seeing you there!
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