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Published Research
The following articles published in peer-reviewed journals resulted from research projects funded in whole or in part by Global Lyme Alliance.
Jie Feng, Wanliang Shi, Judith Miklossy, Genevieve M. Tauxe, Conor J. McMeniman, and Ying Zhang. (2018) Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi. Antibiotics 2018, 7(4), 89;
Persister forms of Borrelia burgdorferi, the bacterium that causes Lyme disease, are dormant or slow-growing, and tolerant of antibiotic treatment. It's not clear yet whether persister bacteria, immune dysfunction, or some combination of the two is responsible for post-treatment Lyme disease syndrome (PTLDS), in which patients treated with antibiotics continue to suffer symptoms.
The search for novel compounds to kill persister bacteria has led to the discovery that essential oils (EOs), aromatic compounds produced by plants, may be promising. In an article published in Antibiotics, a peer-reviewed journal, scientists led by Dr. Ying Zhang of Johns Hopkins University identified 10 EOs that have strong activity against stationary phase B. burgdorferi at a low concentration of 0.1%. The study, underwritten by GLA, found that of the 10 EOs, those of garlic, allspice, and Palmarosa were active at even at 0.05% concentration. In addition, cinnamaldehyde, a major ingredient isolated from cinnamon bark, was active against both stationary phase bacteria as well as replicating B. burgdorferi at a 0.02% concentration.
A stringent test of antimicrobial activity against stationary phase bacteria is the capacity to block subcultured bacteria from growing. This means that after killing bacteria in culture with the inhibitor, a small amount of that culture is transferred to fresh growth media that lacks the inhibitor. Any regrowth indicates that the inhibitor did not completely kill all bacteria from the original culture. Under these conditions, only garlic and cinnamaldehyde were effective against the regrowth of B. burgdorferi spirochetes subcultured for 21 days.
These results indicate that certain EOs or their ingredients are potent in eliminating persister B. burgdorferi, and should be studied in greater depth to analyze their utility as potential treatments. Topics: basic science, chronic Lyme
Besold AN, Culbertson EM, Nam L, Hobbs RP, Boyko A, Maxwell CN, Chazin WJ, Marques AR, Culotta VC. (2018) Antimicrobial action of calprotectin that does not involve metal withholding. Metallomics doi: 10.1039c8mt00133b
Heavy metals like iron, copper, manganese and zinc can be toxic in large amounts. But in low concentrations, they are essential micronutrients for humans as well as bacteria. As part of the defense against invasive microbes, our immune system exploits this property by starving bacteria of the metals they need to survive. One way of doing this is with calprotectin, an immune defense protein produced by neutrophils at the site of infections. Calprotectin depletes the local environment of metal nutrients, and can block Borrelia burgdorferi growth. The mechanism of how this works has now been explained in a newly published study, funded by GLA and led by Dr. Valeria Culotta.
Calprotectin was found in the dermal and epidermal layers of erythema migrans rashes of early Lyme disease patients. It is believed that epithelial keratinocytes in the skin produce calprotectin, which is more commonly associated with neutrophils, immune cells that are absent in this particular site. Surprisingly, calprotectin blocked B. burgdorferi growth not by depleting metals, as would be expected. Instead, it directly bound to the bacteria and changed their shape from spirochetes into a cyst-like form, when immersed in water. This differs from calprotectin's mechanism of blocking another bacteria, E. coli, in which metal sequestration is essential to blocking bacterial replication. These findings suggest a unique new pathway that could be explored for a potential therapeutic that is specific to B. burgdorferi. Topics: treatment, basic science.
Wu X, Sharma B, Niles S, O'Connor K, Schilling R, Matluck N, D'Onofrio A, Hu LT, Lewis K. (2018) Identifying vancomycin as an effective antibiotic for killing Borrelia burgdorferi. Antimicrob Agents Chemother. Aug 20. Doi: 10.1128/AAC.01201-18.
Synopsis: The persistence of symptoms in some Lyme disease patients treated with antibiotics has never been conclusively explained. This is known as post-treatment Lyme disease syndrome (PTLDS). It is possible that in common with animal models like mice and monkeys, human Borrelia burgdorferi infection results in residual, persistent infection even after treatment. Continued bacterial presence and/or an ongoing immune response could cause PTLDS. In an effort to identify antibiotics that might completely eradicate bacterial replication, the GLA-funded research team of Dr. Kim Lewis followed up earlier observations that beta-lactam antibiotics might be effective. The team found that vancomycin was effective against in vitro cultures of growing B. burgdorferi. However, this class of drugs is not expected to work on stationary cells, in which growth is very slow, and cell wall synthesis is expected to be minimal. Unexpectedly, when tested on stationary B. burgdorferi, they found that cell wall synthesis still occurred, and could be blocked by vancomycin. To extend their studies to an in vivo model, the group treated B. burgdorferi-infected, immunodeficient mice for five days. They found that vancomycin and ceftriaxone each completely blocked bacterial growth, compared with partial eradication by doxycycline. These studies suggest that more effective antimicrobial drugs, used early in infection, may prevent or reduce the occurrence of persisting infection. However, ceftriaxone and vancomycin are intravenously administered, and are not justifiable when most Lyme patients recover with oral doxycycline. Better identification of the subset of patients for whom doxycycline is inadequate would pave the way to studying whether vancomycin might reduce the incidence of PTLDS. Topics: chronic Lyme, treatment
Divan A, Casselli T, Narayanan SA, Mukherjee S, Zawieja DC, Watt JA, et al. (2018) Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis PLoS ONE 13(5): e0196893.
Synopsis: A mouse model of neurological Lyme disease would be helpful in understanding how patients develop symptoms and how to treat them. Until now, laboratory mice have not developed neuroborreliosis, which mimics human disease with demonstrated colonization of the central nervous system. However, a new report by Divan et al. gives hope that this may be possible. Using two different strains of B. burgdorferi and infecting mice via the skin, the researchers were able to consistently detect spirochetes in the membranes that surround the brain, called the dura and pia mater. Particularly compelling was the fact that they detected spirochetes 75 days after infection, adhering to blood vessels in the dura and pia mater, and that replicating spirochetes could be cultured from these samples. This suggests that long after acute infection, live spirochetes were still present at these sites. There were also more CD3+ T cells present in the dura of infected animals than in uninfected animals, suggesting an immune response. These findings open the door to new ways of studying neuroborreliosis in vivo. By identifying a site in the brain that is consistently colonized by spirochetes, as well as suggesting which immune pathways may be affected, further studies may reveal potential ways to alleviate the suffering of neuroborreliosis patients. Topics: chronic Lyme
Doshi S, Keilp JG, Strobino B, McElhiney M, Rabkin J, Fallon BA. (2018) Depressive Symptoms and Suicidal Ideation Among Symptomatic Patients With a History of Lyme Disease vs Two Comparison Groups. Psychosomatics doi.org/10.1016/j.psym.2018.02.004 Topics: chronic Lyme, patient care
Synopsis: According to the study, depression has been reported in 8 – 45% of patients with post-treatment Lyme disease syndrome (PTLDS), but little was known about suicidal tendencies in these patients. The extent and severity of depression and suicidality was compared between PTLDS and HIV/AIDS patients, and a non-patient control group was compared. The results conclusively demonstrate that suicidal tendencies increase among patients who are depressed and that, perhaps surprisingly, depression experienced by PTLDS and HIV/AIDS patients was statistically indistinguishable. This seminal study highlights the fact that one in five patients with PTLDS reported suicidal thoughts and the importance of screening for depression and suicidality to optimize patient care.
Kitsou C, Pal U. (2018) Ixodes immune response against Lyme disease pathogens. Front Cell Infect Microbiol 8:176. doi: 10.3389/fcimb.2018.00176 Topics: review
Lin Y-H, Chen Y, Smith TC, Rajasekhar Karna SL, Seshu J. (2018) Short-chain fatty acids alter metabolic and virulence attributes of Borrelia burgdorferi. Infec Immun 86(9): pii e00217-18. doi: 10.1128/IAI.00217-18. Topics: basic science
Strobino B, Steinhagen K, Meyer W, Scheper T, Saschenbrecker S, Schlumberger W, Stöcker W, Gaito A, Fallon BA. (2018) A community study of Borrelia burgdorferi antibodies among individuals with prior Lyme disease in endemic areas. Healthcare 6(2):69. doi:10.3390/healthcare6020069. Topics: patient care
Uhde M, Indart A, Fallon BA, Wormser GP, Marques AR, Vernon SD, Alaedini A. (2018) C-reactive protein response in patients with post-treatment Lyme disease symptoms versus those with myalgic encephalomyelitis/chronic fatigue syndrome. Clin Inf Dis. 67(8):1309–1310. doi.org/10.1093/cid/ciy299. Topics: basic science, diagnostics
Tracy KE and Baumgarth N. (2017) Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts Frontiers in Immunology (2017) Vol 8, page 116. doi: 10.3389/fimmu.2017.00116
Synopsis: A review by Tracy and Baumgarth illustrates the complexity of Borrelia interactions with the immune system. In a masterful, thorough discussion, the authors outline current thinking of how the family of bacteria responsible for Lyme disease and other inflammatory illness persists in animals. They do so by escaping and subverting numerous immune system pathways, most notably in the principal reservoir host, the white-footed mouse. This species of mouse does not become symptomatic, and the authors explain ways that the immune response proceeds differently in the lab mouse, which does. In addition, the bacterium alters its surface proteins during various stages of infection, which makes it a moving target, but also enhances its ability to replicate and spread within the host. Finally, the authors point out that critical components of the adaptive immune response, which allow the production of highly specific and potent antibodies and immune cells, are disabled by Borrelia infection. Further study will illuminate how to target the bacteria more effectively, and to prevent persistent infection and immune dysfunction. Topics: chronic Lyme
Feng J, Zhang S, Shi W, Zhang Y. (2017) Activity of sulfa drugs and their combinations against stationary phase B. burgdorferi in vitro. Antibiotics 6:pii:E10. Doi: 10.3390/antibiotics6010010.
Synopsis: About 10-20% of Lyme disease patients treated with antibiotics continue to suffer debilitating symptoms, known as post-treatment Lyme disease. It is not understood whether this is due to an inappropriate immune response or continued Borrelia bacterial replication. In vitro laboratory experiments have showed that persister forms of bacteria are difficult to eliminate with antibiotics. This is because persisters are very slow-growing, and most antibiotics target actively-replicating bacteria. Limited clinical observations suggested some efficacy of dapsone, a sulfa drug, which belongs to a class of antibiotics not commonly used to treat Lyme disease. To test this drug against persister forms, Dr. Ying Zhang's group studied sulfamethoxazole, dapsone, and sulfachlorpyridazine singly as well as in combination. By themselves, these drugs had similar efficacy as doxycycline, with 59-92% of stationary bacteria still alive after treatment. Their bacteria-killing activity was weak compared to daptomycin, which when used at the same concentrations, resulted in 26-52% of remaining cell viability. As combinations, they could not completely eradicate persister bacteria, with 74-77% bacteria remaining viable after treatment. But when they were combined with non-sulfa drugs like doxycycline, cefuroxime, ciprofloxacin, rifampin, and azithromycin, the rate of bacterial killing was higher. The most effective combinations included daptomycin. Further research will identify effective combinations that will more completely eradicate persister bacteria in vitro and in patients. Topics: chronic Lyme
Bouquet J, Melgar M, Swei A, Delwart E, RS, Chiu CY. (2017) Metagenomic-based surveillance of Pacific coast tick Dermacentor occidentalis identifies two novel bunyaviruses and an emerging human ricksettsial pathogen. Sci Rep. 7:12234. doi:10.1038/s41598-017-12047-6. Topics: basic science, tick biology
Alaedini A, Lebwohl B, Wormser GP, Green PH, Ludvigsson JF. (2017) Borrelia infection and risk of celiac disease. BMC Med.15:169. doi: 10.1186/s12916-017-0926-1. Topics: patient care
Jessen Condry DL, Bradley DS, Brissette CA. (2017) Design of a Lyme disease vaccine as an active learning approach in a novel interdisciplinary graduate-level course. J Microbiol Biol Edu DOI: https://doi.org/10.1128/jmbe.v18i3.1304. Topics: education
Rebman AW, Bechtold KT, Yang T, Mihm EA, Soloski MJ, Novak CB, Aucott JN. (2017) The Clinical, Symptom, and Quality-of-Life Characterization of a Well-Defined Group of Patients with Posttreatment Lyme Disease Syndrome. Front Med (Lausanne) 4:224. doi: 10.3389/fmed.2017.00224. Topics: diagnostics, patient care, chronic Lyme
Stone BL, Tourand Y, Brissette CA. (2017) Brave new worlds: the expanding universe of Lyme disease. Vector-borne Zoo Dis 17:619. Topics: basic science, tick biology
Feng J, Zhang S, Shi W, Zhang Y. (2016) Ceftriaxone pulse dosing fails to eradicate biofilm-like microcolony B. burgdorferi persisters which are sterilized by daptomycin/doxycycline/cefuroxime drug combination without pulse dosing. Front Microbiol. Doi: 10.3389/fmicb.2016.01744.
Synopsis: At least 10% of patients treated with antibiotic therapy for Lyme disease continue to suffer persisting symptoms. The reason for this is unknown, but one suspect is the continued survival of persisting forms of B. burgdorferi, the bacterium responsible for Lyme disease. In the test tube, Zhang and colleagues have grown one form of persisting bacteria known as biofilms, and used it to test various combinations of antibiotics. They also compared single continuous dosing versus pulse-dosing, which consists of repeated cycles of adding and removing antibiotics. They found that pulse-dosing was not effective for all antibiotics, and in fact reduced the activity of daptomycin against persisters. The best strategy they found against biofilm-like persisters was a single dose of a combination of daptomycin, doxycycline, and cefuroxime. They also showed that bacteriocidal drugs, which kill bacteria, are better used in pulse dosing than bacteriostatic drugs, which block bacterial replication but do not directly kill them. These promising in vitro data pave the way for animal model studies. If the findings prevail, they may suggest that future human trials are warranted. Topics: chronic Lyme
Uhde M, Ajamian M, Li X, Wormser GP, Marques A, Alaedini A. (2016) Expression of C-reactive protein and serum amyloid A in early to late manifestations of Lyme Disease. Clin Infect Dis. first published online September 1, 2016doi:10.1093/cid/ciw599.
Synopsis: The human immune response to invasive microbes consists of two major arms: the innate and the adaptive response. The innate response occurs rapidly after infection, when the host tries to contain or inactivate the microbe. Two proteins involved in this process are C-reactive protein (CRP) and serum amyloid A (SAA), which are often elevated in the blood during an inflammatory response. In this study, the researchers analyzed CRP and SAA in the blood of people with varying stages of Lyme disease. They found that compared to healthy people, CRP was elevated in early Lyme disease, when patients had erythema migrans (EM) skin rashes. In contrast, CRP levels in patients with early or late neurological symptoms and arthritis were similar to healthy controls. However, patients with post-treatment Lyme disease syndrome (PTLDS) had higher CRP levels that those who recovered, suggesting ongoing inflammation in patients with long-term Lyme disease. SAA was elevated in patients with EM rashes, but was similar to healthy controls in all other patients, including those with PTLDS. These findings suggest that persisting symptoms after antibiotic therapy are associated with elevated CRP, and pave the way for further studies to understand long-term inflammatory processes in these patients. Topics: chronic Lyme
Aucott JN, Soloski MJ, Rebman AW, Crowder LA, Lahey LJ, Wagner CA, Robinson WH, Bechtold KT. (2016) CCL19 as a Chemokine Risk Factor for Post Treatment Lyme Disease Syndrome: A Prospective Clinical Cohort Study. Clin Vaccine Immunol. June 29. Pii: CVI.00071-16. (Epub ahead of print)
Synopsis: An estimated 10-20% of Lyme disease patients who are treated with antibiotics continue to suffer persisting symptoms 6 to 12 months later. This is known as post-treatment Lyme disease syndrome, because it may affect various organs. Symptoms include chronic pain, overwhelming fatigue, and neurological or psychiatric symptoms. It is not known why this occurs in a subset of treated patients, but an aberrant immune response has long been suspected. In a new study led by Dr. John Aucott of Johns Hopkins University, elevated CCL19 was identified as associated with persistent symptoms. During acute infection, all patients diagnosed with Lyme disease (defined by physician-diagnosed erythema migrans rash) had elevated CCL19. However, by one month after diagnosis and treatment, those with serum concentrations greater than 112 pg/ml were 13 times more likely to develop post-treatment symptoms at 6 and 12 months later. Other patients who recovered, or who had symptoms without functional impairment had lower CCL19 levels after one month. CCL19 is produced by activated dendritic cells, which are sentinel cells that recruit immune cells to the site of an infection. The authors propose that sustained, elevated CCL19 is linked to continued inflammation and may account for ongoing symptoms, but point out that further studies are needed to understand the mechanistic basis and to identify other relevant immune pathways. Topics: chronic Lyme
Feng J, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y. (2016) A drug combination screen identifies drugs active against amoxicillin-induced round bodies of in vitro Borrelia burgdorferi persisters from an FDA drug library. Front Microbiol. May 23;7:743. doi: 10.3389/fmicb.2016.00743.
Synopsis: In lab culture, Borrelia burgdorferi, the bacterium that causes Lyme disease, can survive amoxicillin treatment by transforming into a round-body form. Such round bodies persist in a slowly-growing state and are tolerant of antibiotics. In this study, the authors tested 1581 drugs that are already approved by the FDA, for antimicrobial activity against amoxicillin-induced round-bodied B. burgdorferi. They found 23 drugs with activity against the round bodies when used singly. In addition, they identified artemisinin, a malaria drug, in combination with cefoperazone and doxycycline, as well as sulfachlorpyridazine together with daptomycin and doxycycline as potent combinations that reduced round bodies. Importantly, these combinations also had some durable inhibitory effect, because re-growth after subculture was low. These findings provide evidence that the continued search for effective drug combinations against persister bacteria is warranted. Topics: treatment, chronic Lyme
Bouquet J, Soloski MJ, Swei A, Cheadle C, Federman S, Billaud JN, Rebman AW, Kabre B, Halpert R, Boorgula M, Aucott JN, Chiu CY. (2016) Longitudinal Transcriptome Analysis Reveals a Sustained Differential Gene Expression Signature in Patients Treated for Acute Lyme Disease. mBio. Feb 12;7(1). pii: e00100-16. doi: 10.1128/mBio.00100-16.
Synopsis: The genes that are expressed in sick people differ from those who are healthy. Using advanced sequencing techniques, these researchers found that immune cells in the blood of people with Lyme disease express different genes from those of healthy controls. Genes that are linked to a strong immune response were reduced in Lyme patients compared to those with other bacterial or viral infections. People with persisting symptoms attributed to Lyme disease shared some gene expression patterns with patients suffering chronic illnesses caused by immune system dysfunction. Topics: diagnostics, treatment, chronic Lyme
Feng J, Weitner M, Shi W, Zhang S, Zhang Y. (2016) Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime. Front Microbiol. Feb 10;7:62. doi: 10.3389/fmicb.2016.00062.
Synopsis: The persistence of symptoms in Lyme patients treated with antibiotics may be due to the bacteria becoming tolerant to drugs. In lab culture, persistent Lyme bacteria grown into biofilm form were exposed to various antibiotic combinations. The authors found that double antibiotic combinations such as doxycycline and cefoperazone were not enough for biofilm eradication. The addition of either daptomycin or daunomycin was required for bacterial elimination. Topics: treatment, chronic Lyme
Jacek E, Tang KS, Komorowski L, Ajamian M, Probst C, Stevenson B, Wormser GP, Marques AR, Alaedini A. (2016) Epitope-Specific Evolution of Human B Cell Responses to Borrelia burgdorferi VlsE Protein from Early to Late Stages of Lyme Disease J Immunol 196:1036-43.
Synopsis: Lyme disease patients make antibodies that recognize Borrelia burgdorferi, the bacteria that cause illness. When the disease progresses from early to late stages, these antibodies may change. A protein on the outside of B. burgdorferi is called VlsE, and antibodies that bind to a portion of it called the membrane-proximal domain illustrate this. These specific antibodies were low in patients with early disease, and were increased in patients with symptoms typical of later illness, such as neurological symptoms. Topics: diagnostics, treatment, chronic Lyme
Lahey LJ, Panas MW, Mao R, Delanoy M, Flanagan JJ, Binder SR, Rebman AW, Montoya JG, Soloski MJ, Steere AC, Dattwyler RJ, Arnaboldi PM, Aucott JN, Robinson WH. (2015) Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease. J Clin Microbiol 53(12):3834-41. Epub 2015 Oct 7.
Synopsis: The current blood test for Lyme disease has low accuracy. In this study, the authors designed and tested a new blood test that is more accurate. They used portions of proteins, called peptides, from Borrelia burgdorferi, the bacteria that cause Lyme disease. For a patient to be scored as positive, their blood had to contain antibodies that would recognize at least 2 of the 10 bacterial peptides. This test was more sensitive than the current blood test, and could be developed into a newer generation of diagnostic test for Lyme disease. Topics: diagnostics
Feng J, Shi W, Zhang S, Zhang Y. (2015) Persister mechanisms in Borrelia burgdorferi: implications for improved intervention. Emerg Microbes Infect Aug 4 (e51). Epub 2015 Aug 19.
Synopsis: Lyme disease is caused by the bacteria called Borrelia burgdorferi. In lab cultures of B. burgdorferi that are treated with antibiotics, most are killed. However, some become persister bacteria that survive. The authors used RNA sequencing to study how the genes that are expressed may differ in persister compared to drug-free bacteria. They found that expression changes in 675 genes in persister bacteria. Topics: treatment, chronic Lyme
Ajamian M, Cooperstock M, Wormser GP, Vernon SD, Alaedini A. (2015) Anti-neural antibody response in patients with post-treatment Lyme disease symptoms versus those with myalgic encephalomyelitis/chronic fatigue syndrome. Brain Behav Immun 48;354-355.
Synopsis: Patients with persisting Lyme symptoms were previously found to have higher and more frequent anti-neural antibodies compared to people who were healthy or who had recovered from Lyme disease. Patients with chronic fatigue syndrome (CFS) and persisting Lyme disease often have similar symptoms. This study found that CFS patients do not have elevated anti-neural antibodies. Thus, the common symptoms of persisting Lyme and CFS are not likely due to anti-neural antibodies. Topics: diagnostics, chronic Lyme
Timmaraju VA, Theophilus PAS, Balasubramanian K, Shakih S, Luecke DF, Sapi E. (2015) Biofilm formation by Borrelia burgdorferi sensu lato. FEMS Microbiol Lett 362:fnv120.
Synopsis: The authors studied whether B. afzelii and B. garinii, two bacteria associated with Lyme disease in Europe, are capable of growing as biofilms in lab culture. Using chemical stains and microscopy, they showed that these two bacteria form biofilms, similar to B. burgdorferi, the North American species, when grown under specific lab culture conditions. Topics: treatment, chronic Lyme
Feng J, Auwaerter PG, Zhang Y. (2015) Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline. PLoS One. 10(3): e0117207.
Synopsis: The persistence of Borrelia burgdorferi in the form of drug-tolerant bacteria may be one reason why some Lyme disease patients may continue to suffer symptoms despite antibiotic therapy. The authors determined which drug combinations were effective in eradicating persistent microcolonies of B. burgdorferi, and identified daptomycin, doxycycline and cefoperazone together as an effective way of eliminating bacteria. Even subculturing bacteria treated with this combination to fresh media did not result in bacterial growth, suggesting durable killing. Topics: treatment, chronic Lyme
Tang KS, Klempner MS, Wormser GP, Marques AR, Alaedini A. (2015) Association of immune response to endothelial cell growth factor with early disseminated and late manifestations of Lyme disease but not posttreatment Lyme disease syndrome. Clin Infec Dis 61:1703-6.
Synopsis: The persistence of symptoms in patients treated for Lyme disease remains unexplained. One possible reason could be immune system dysfunction, including antibodies that react against the patient. To study this possibility, these researchers studied whether antibodies targeting endothelial cell growth factor, a normal human protein, were associated with post-treatment Lyme disease syndrome. They found that while antibodies were observed in patients with early and later disease symptoms, they were mostly absent in patients with post-treatment Lyme syndrome. Topics: chronic Lyme
Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K. (2015) Borrelia burgdorferi, the causative agent of Lyme disease, forms drug-tolerant persister cells. Antimicrob Agents Chemother 59(8):4616-24. Epub 2015 May 26.
Synopsis: Persisting bacteria survive antibiotic treatment in lab culture. Here, the authors showed that antibiotics killed most of lab-grown B. burgdorferi, with a small surviving population that tolerated drug treatment. They found that mitomycin C, a cancer drug, efficiently killed persisters. They also showed how pulse-dosing, wherein four repetitive cycles that included treating bacterial cultures with ceftriaxone, followed by washing out the drug, resulted in eradication of persistent bacteria. Topics: treatment, chronic Lyme
Divan A, Budd RC, Tobin RP, Newell-Rogers MK. (2015) γδ T Cells and dendritic cells in refractory Lyme arthritis. J Leukoc Biol 97(4):653-663. Epub 2015 Jan 20.
Synopsis: This is a review about the function of γδT cells, a specialized subset of T cells that are important in coordinating the immune response when it transitions from the innate, or immediate response, to the adaptive, more specific immune reaction. It focuses on these cells during refractory Lyme arthritis. Topics: chronic Lyme
Feng J, Wang T, Zhang S, Shi W, Zhang Y. (2014) An optimized SYBR Green I/PI assay for rapid viability assessment and antibiotic susceptibility testing for Borrelia burgdorferi. PLoS One. 9(11)e111809.
Synopsis: The authors analyzed various methods to efficiently and accurately count live and dead Borrelia burgdorferi in lab culture. This is important for calculating the efficacy of antibiotics in the killing of bacteria. They adapted a method that stains live bacteria green, and dead ones red, allowing simple, reproducible, and high-throughput means to count bacteria. Topics: treatment, chronic Lyme
Fallon BA, Pavlicova M, Coffino SW, Brenner C. (2014) A comparison of Lyme disease serologic test results from 4 laboratories in patients with persistent symptoms after antibiotic treatment. Clin Infect Dis 59:1705-10.
Synopsis: Diagnosis of Lyme disease in late-stage patients is often erroneous. Fallon and colleagues compared Lyme disease test results from four different testing labs, using blood samples from previously diagnosed Lyme patients and healthy controls. Overall, they found variation in results, but no statistically significant difference between labs. However, there was a higher positivity rate for the C6 test, than for whole bacterial sonicate used in the diagnostic test. Topics: diagnostics, chronic Lyme
Feng J, Wang T, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y. (2014) Identification of novel anti-persister activity against Borrelia burgdorferi from an FDA-approved drug library. Emerg Microbes Infect Jul 3 (e49). Epub Jul 2.
Synopsis: A library of drug compounds that has already been approved by the FDA was tested for efficacy against persister forms of Borrelia burgdorferi that were grown in lab culture. They identified daptomycin, clofazimine, sulfa drugs, and cefoperazone as potential drugs worth pursuing in further studies, which may include animal models of Lyme disease. Topics: treatment, chronic Lyme
Soloski MJ, Crowder LA, Lahey LJ, Wagner CA, Robinson WH, Aucott JN. (2014) Serum inflammatory mediator as markers of human Lyme disease activity. PLoS One. 9(4):e93243.
Synopsis: The authors compared the blood of patients suffering more severe symptoms of Lyme disease against those with less. They found that the pattern of chemokines, which are chemical messengers produced by immune cells, varies between the two groups. This work may lead to better diagnostic tools and clinical treatments, and shows a biological difference between these two groups of patients. Topics: diagnostics, treatment, chronic Lyme
Zhang Y. (2014) Persisters, persistent infections and the Yin–Yang model. Emerg Microbes Infect 3(e3).
Synopsis: In this review, Dr. Zhang discusses the differences between B. burgdorferi persister and growing cells, and proposes a model for bacterial transition between the two states, with the balance tipped depending on the environment and stresses such as antibiotics. Topics: treatment, chronic Lyme
Jacek E, Fallon BA, Chandra A, Crow MK, Wormser GP, Alaedini A. (2013) Increased IFN-α activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits. J Neuroimmunol. 255:85–91.
Synopsis: Some patients treated for Lyme disease continue to suffer neurological symptoms. In these patients compared to healthy controls, there was increased interferon-α (IFNα) activity observed in the blood. IFNα is a cytokine, or chemical messenger, and together with the observation of elevated antibodies against B. burgdorferi and neural proteins, suggests an ongoing inflammatory response in these patients. Topics: treatment, chronic Lyme
Batheja S, Nields JA, Landa A, Fallon BA.(2013). Post-treatment lyme syndrome and central sensitization. J Neuropsychiatry Clin Neurosci. Summer;25(3):176-86.
Synopsis: A significant subset of patients treated for Lyme disease continue to have symptoms that persist for months or years. These may include pain, fatigue and neurocognitive problems, and collectively has been termed post-treatment Lyme disease syndrome. Whether these patients have ongoing infection is difficult to assess using current technology, and remains an open question. It is also possible that a post-infectious immune-mediated process may be responsible for continued symptoms. Here, the authors review central sensitization syndrome, in which pain and sensory processing is elevated. They discuss whether central sensitization may be related to continued symptoms in post-treatment Lyme disease.Topic: chronic Lyme
Chandra AM, Keilp JG, Fallon BA. (2013) Correlates of perceived health-related quality of life in post-treatment Lyme encephalopathy. Psychosomatics 54:552. Topics: patient care, chronic Lyme
Goessling LS, Allan BF, Mandelbaum RS, Thach RE. (2012) Development of a mitochondrial 12S rDNA analysis for distinguishing Sciuridae species with potential to transmit Ehrlichia and Borrelia species to feeding Amblyomma americanum (Acari: Ixodidae). J Med Entomol 49(3):772-6.
Synopsis: The authors used a new DNA identification technique to observe that Lone Star ticks in Missouri harbor DNA from both pathogenic bacteria (Ehrlichia and Borrelia) as well as from the species of squirrels on which they feed, the Eastern gray squirrel and the generic squirrel. It was not previously known that these squirrels are hosts for disease-carrying ticks. Topics: prevention
Schutzer SE, Angel TE, Liu T, Schepmoes AA, Clauss TR, Adkins JN, Camp DG II, Holland BK, Bergquist J, Coyle PK, Smith RD, Fallon BA, Natelson BH. (2011) Distinct cerebrospinal fluid proteomes differentiate post-treatment Lyme disease from chronic fatigue syndrome. PLoS One. 6(2):e17287.
Synopsis: Chronic fatigue syndrome patients and post-treatment Lyme disease patients share some similar neurological symptoms. This study showed that the protein profiles in cerebrospinal fluid from the two groups were distinctive, suggesting that they are two different diseases. Topics: diagnostics, treatment, chronic Lyme
Chandra A, Latov N, Wormser GP, Marques AR, Alaedini A. (2011)Epitope mapping of antibodies to VlsE protein of Borrelia burgdorferi in post-Lyme disease syndrome. Clin Immunol 141:103-110.
Synopsis: The immune response to B. burgdorferi infection includes the production of antibodies that recognize bacterial surface proteins, one of which is called VlsE. Proteins form complex three-dimensional shapes, and only parts of them, called epitopes, are recognized by antibodies. Alaedini's group mapped these on VlsE. The antibodies against VlsE differ in patients with later compared to earlier stages of Lyme disease. Topics: diagnostics, chronic Lyme
Newell MK, Tobin RP, Cabrera JH, Sorensen MB, Huckstep A, Villalobos-Menuey EM, Burnett M, McCrea E, Harvey CP, Buddiga A, Bar-Or A, Freedman MS, Nalbantoglu J, Arbour N, Zamvil SS, Antel JP. (2010) TLR-mediated B cell activation results in ectopic CLIP expression that promotes B cell-dependent inflammation. J Leuk Biol 88:779-789.
Synopsis: In this article, the authors used a mouse model to study B cells, which when activated, produce antibodies and release inflammatory cytokines, or chemical messengers. They found that a protein called CLIP is important in controlling B cells, and speculated that it shows a potential pathway to control chronic immune activation diseases such as Crohn's disease and post-treatment Lyme disease. Topics: treatment, chronic Lyme


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Welcome to Education Policy Studies!
A message from the Department Head:
I am excited to be a part of the Department of Education Policy Studies at Penn State – without question, this is one of the top departments of its kind in the United States. Our 30 full-time faculty lead programs in Educational Theory and Policy, Educational Leadership, and Higher Education that are each ranked in the top ten in their fields by US News and World Report. Cutting edge research is conducted in faculty-led Centers for the Study of Higher Education, Education and Civil Rights, Education Disparities Research, Rural Education and Communities, and Evaluation and Education Policy Analysis. Our Comparative and International Education Dual Degree offers students a unique view into global education policy and practice. The Education and Public Policy program gives undergraduates a comprehensive understanding of the challenges and opportunities in education today. A robust community of students have access to online programs wherever they happen to reside, guided by the same faculty and the same curriculum as in-person students find at University Park. We have a strong and supportive department culture that includes nearly 400 students, including full- and part-time bachelor's, master's, doctoral, and K-12 administrative certification students. A third of our doctoral students are fully-funded with tuition and stipends to work with faculty on various projects.
Whether you want to be a school principal, an education policy analyst, a university administrator, or a scholar of international education systems, we have the faculty expertise and connections to the field to serve you.
As Department Head, I want to invite you to explore our programs and get to know our faculty. Get a sense of what we have to offer. I'm sure you'll agree that my enthusiasm is more than justified. This is a great place to be!

subset: commoncrawl


text: COLCHESTER A priest whose New Orleans parish was hard hit by Katrina and whose connections go back to the Civil Rights Movement will be the featured speaker at the Saint Michaels College annual Martin Luther King Jr. Convocation, on Monday, Jan. 21, at 3:30 p.m. in the Chapel of Saint Michael the Archangel. The convocation will also include a student dramatization of the Langston Hughes poem Let America be American Again and music by the Saint Michaels Liturgical Choir. The public is welcome to attend this free convocation. Featured speaker Rev. Michael A. Jacques, SSE, priest for New Orleans St. Peter Claver Church, renowned for his oratory, will speak on the topic, From the Civil Rights Movement to Katrina: Searching for Justice and Hope. Father Jacques will speak of the Civil Rights history of the Society of St. Edmund, the order of priests who are founders of Saint Michaels College. The Edmundites have missions in New Orleans and Selma, Ala., where they were present as activists and witnesses during Dr. Kings 1965 Bloody Sunday Civil Rights March from Selma to Montgomery. Father Jacques will speak also of post-Katrina New Orleans, where his parish was amongst the hardest hit in the city. The Saint Michaels Liturgical Choir, directed by Jerome Monachino, assistant director of Edmundite Campus Ministry, performs in its own eclectic and popular musical style, using a combination of African, Latin American and Irish flavors along with traditional hymn singing. Guided by their mission of inspiring sung prayer, they perform with wonderful enthusiasm and greatly enhance the experience of all who hear them.


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The Fisher-Price Infant to Toddler Baby Bouncer is a good solid rocker with lovely bright colours and patterns. The harness is nice and secure and the toy arch fits snugly into the side clasps. It has a wipe clean surface, which makes it easy to clean.
The Rocker vibrates and plays music to keep baby entertained. The toy bar sits quite close to baby's face which makes the accessories easy to grab (the monkets are really cute!) but perhaps likely to over-stimulate little ones too. It also has to be removed to get baby in and out of the chair, which can become inconvenient.
The Rocker has two positions but manoeuvring between them is awkward, requiring two buttons to be pushed in and then further fingers to pull or push seat up or down. Additionally, the product is not suggested for tiny babies as there is no head-support insert but overall a fun, practical product that babies will enjoy!


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C-80, Marudhar Industrial Area,
Basni Phase - II, Jodhpur - 342005.
Shree Ram Industries serves best quality in food grade and industrial grade of guar gum…
Shree Ram Industries will persist to handle Industrial Grade Division in addition to an upgraded product range of guar gum powder.
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Guar Meal, a byproduct of guar gum and consisting of seed coat and germ material, is a good sourceRead More...
ISO 22000 Certified Company
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Strictly Top Quality seeds used in the manufacturing
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Different verticals for manufacturing, quality assurance, storage and packaging
Guargum prices were down by Rs. 90 to Rs. 7,880 per quintal in futures trading today as traders were seen trimming, t
Guar gum powder is extracted from the guar bean (cyamopsis tetragonolobus), which grows in India and Pakis
discoveries in the cosmetics industry for news on creams and lotions that promise to be gentle on our


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Best earrings for women: different types for your face shape
Earrings are important accessories for your look. It can enhance your overall attractiveness or hide your flaws. For a girls, there are so many styles of different earrings to choose from, it is sometimes hard to make the right choice. Unless you have the perfect small oval face, not all types of earrings are flattering on your face. This hub talks about the different earring styles and which ones you should choose by face shape!! Enjoy and you will be more beautiful after reading this hub, I promise!!
Round faces. The best one for round faces is the drop earrings. A pair of long and skinny earrings will help you balance out the roundness of your face. This style is very classic and will look great with almost any outfit. Choose simple ones for a more causal occasion and fancy ones for a more formal occasion. Earrings with geometric shape that are long can also help upset the roundness of your face. The reason is because those earrings are opposite of roundness. It is wise to pick those carefully because you don't want to add more width to your face. Hoop and stud earrings are a definite no for round faces.
Square faces. Because of the squareness of you face, it is better to make your face look softer with more feminine earrings. A pair of earrings that has some flowery elements of pretty rounder shapes are the best for the square face. You would want to avoid any geometric shapes because it will only emphasize the squareness of your face.
Long faces. Earrings should be used to make the face look shorter. The hoop earrings are best here because it will add width to your narrow face. Your hairstyle should also be used to create that extra width. A pair of long earrings should be avoided because it will make the face look even longer. Little stud earrings are also very good here when you want minimal jewelry. Here is a good look for the long faced girl: pull back your hair in a ponytail but have some bangs covering your forehead and complete the look with stud earrings. This look is very simple yet elegant. The bangs are very important because it will significantly shorten your face.
Heart shaped faces. You have a bigger higher forehead with a very narrow chin. Earrings should be used to balance the little narrow chin with your bigger forehead. Use earrings that are narrow at the top but bulky near the bottom. The hoop, chandelier and geometric ones should all work for you. The stud and long earrings are not as flattering. Those earrings that are big on top and gradually get smaller mirrors your own face shape and needs to be avoided at all times.
Oval faces. You are a lucky girl because this is the perfect face shape that can accommodate almost all earring types. You should choose ones that is best for the occasion and one that you love. However, if you are a very petite girl, you should definitely avoid those very big or long earrings. It will just weigh you down. Choose one that is proportional to your own body. But otherwise, just have fun!
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Today I'm pleased to welcome author Danica Winters to the blog to talk a little bit about her novel The Vampire's Hope and being a writer.
What was the plot of your very first piece of unpublished fiction you ever wrote?
LOL Oh GEEZ! That's a terrible question. My first full length novel was dreadful. It was about a man who fell in love with a waitress, but was being stalked by his former girlfriend (a schizophrenic killer).
It was awful, but it was my first attempt at writing professionally and it was what started me writing. So even though it was the worst book EVER, I'm glad I wrote it. It inspired me to always keep learning and working on my craft.
Writers tend to have a pretty active imagination for obvious reasons, if you had to describe what the inside of your head was like what would you tell us?
I don't think anyone would want to live in my head. Most days I think I may actually have a Mom brain—one simple thought turns into a list of a thousand things that I need to do, say, write, and/or change. I'm constantly working on something.
How did you come up with the idea The Vampires Hope?
I'm a Wikipedia addict and I was researching Pandora's Box (which is actually a jar). I read about the Keres, or hope—which in Greek mythology is considered to be evil. They believed hope garnered weakness. And I immediately had to write the story.
As you were writing The Vampire's Hope, was there a particular scene or character that surprised you, like doing something you didn't expect or a scene taking you somewhere you hadn't planned?
I love Lady Katherine—she was so dark and dangerous. And without telling too much, there's a possibility that she may end up in the next book in the series.
Who was the hardest character to write in The Vampire's Hope? Why?
I have to say this would be the main character, Ellie. In the beginning of the story, she is unable to feel and is an emotional abyss. As a woman, I'm an emotional creature and I had a hard time thinking about how it would be to be without the constant ebb and flow of emotions.
What are you most satisfied about when it comes to The Vampire's Hope?
Here's the honest truth, Vampire books are hard to write. Not because the premise is hard or the plot is a challenge, it is because of the market. People tend to only want one of two Vampires—either the sparklers (which I do like) or the synthetic blood drinkers (which I also like). When I wrote a vampire who drinks blood fresh from the vein, there have been some readers that hate this.
I knew the risk of working with 'bad' vamps. I went with my heart and took these characters where they needed to go and used the 'true' vampires as my premise. They are slightly antagonistic, but they are historically what vampires have been (think Dracula). And I ended up loving them more for it.
Do you prefer hard copy books or e-readers, why?
I used to be a diehard paperback reader. However, now that I found I can listen to books on my Kindle I find that this is my preferred method of reading. My eyes get tired after a long day of writing and editing and it's nice to just lay back and listen to a good book at night!
When you're not writing, what do you like to do?
There are few moments when I'm not writing, editing, plotting, or on social media, but when I do have free time I love to spend time with my family in the outdoors. This time of year I love to sled. We have a steep driveway and a four-wheeler which makes for ideal sledding (I don't have to hike back up the hill).
Read any good books recently?
I'm always reading. Lately I have been reviewing books for new authors and I read Josey's Christmas Cookie about a hound dog and it's owner. It was a short story, but it was so cute! I also recently read California Sunset by Casey Dawes. It was such a great book!
Who are your five favorite authors and why?
Bram Stoker
Jane Austen
Helen Fielding (Bridget Jones' Diary)
Charlaine Harris
Suzanne Collins
Thanks so much for taking the time to answer our questions! More information on Danica Winters can be found below:
Danica Winters is an Amazon best-selling romance author based in Montana. She is known for writing award-winning books that grip readers with their ability to drive emotion through suspense and often a touch of magic. She is a member of Romance Writers of America, Montana Romance Writers, and Greater Seattle Romance Writers. She is a contributor to magazines, websites, and news organizations. She enjoys spending time with friends and family, the outdoors, and the bliss brought by the printed word.
GIVEAWAY: 15 Ebook copies of The Vampire's Hope by Danica Winters Ends Feb. 8th


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School Nursing Service
The School Nursing Service provides a confidential service to our students. Our school nurse is Coralie Brandon.
Our school nurses work both in and out of school to provide support around:
- Keeping healthy
- Child protection
- Immunisations
- Emotional health and wellbeing
- Weight management
- Long term medical conditions
- Sexual health and contraception
- Substance misuse
- Risk taking behaviours
- Staff medical training (Anaphylaxis/ Epilepsy)
- More support for those who need it most
Students are able to make a formal appointment with the nurse or can 'drop in' on a Wednesday lunchtime.


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Military police in Stung Treng province's Sesan distict arrested three journalists and one of their wives yesterday for allegedly attempting to extort money from military police officers they believed to be transporting illegal timber, police and the rights group Adhoc said.
According to Adhoc coordinator Huor Sam Ol, those arrested were Neaka Reach Newspaper publisher Kim Sovananrith, 41; his wife, Try Chenda, 32; and reporters Kim Khoeun, 28, and Mom Mun, 54, who worked for the publications Cheat Khmer and Sangkum Khmer, respectively.
The four were passing through Stung Treng on their way to Phnom Penh when they saw military police officers transporting wood they believed to be contraband, Sam Ol said. They then allegedly stopped the men and asked for money in exchange for not publishing a story.
"The case will be sent to court, and the four are charged with extortion," Sam Ol said.
Eav Sameth, deputy chief of the Stung Treng Provincial Criminal Police Office, said the journalists had demanded $500, but what the journalists thought was illegal timber was actually for building a house. He added that they were scheduled to appear in court today.
Adhoc's Sam Ol urged investigators not to base the case solely on the word of military police officers involved.


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The Geo Fly Vest range offers quality, style and above all functionality, all rolled into one. Using the latest CVC material, this novel blend of 50% cotton, 50% polyester gives the soft feel of brushed cotton, coupled with the strength, durability and fast drying properties associated with polyester. Designed by fly-fishers, every pocket is there for a reason and not just because there was space available.
. Breathable foam padding across the shoulders
. Knitted, self-colour collar for comfort
. 4 main box-design outer pockets
. 5 additional front accessory pockets for floatants, sinkants, leaders etc.
. 2 front zip pockets for extra storage
. Concealed coil retractors on front of vest
. 2 internal 100% waterproof pockets
. Micro-fibre sunglass cleaning cloth
. Further internal zipped & mesh pockets
. Internal priest pocket
. Large rear bellows pocket, outer mesh pocket
. Full length zip one side for large items, short zip on the left hand side allows a water bottle or spare spool to be easily retrieved
. Rear hanging loop, rear net D-ring plus 2 front and 2 side D-rings
. Front rod loop and Velcro tag
. Velcro removable fly drying ripple foam
. Quick-pull Aztec pattern material tabs on zips
colour: Sage Green
Sizes: M, L, XL, XXL
DWR Coating In addition, the material is treated with a DWR (Durable Water Repellent) finish. This chemical treatment forces water to bead up and roll off the surface of the fabric, which enhances the water-resistant properties and keeps the fabric light, by not soaking up water. This super durable application will retain its properties even after repeated use and washings.
A short wading vest to rival the best.
This shorter model, shares many of the quality features of the
longer model, plus...
. All main pockets have waterproof lining with heat-tape sealed seams and waterproof zips
. Deep 'box design' pockets will hold the largest of fly boxes
. 2 zipped front mesh pockets, plus 2 zipped inside pockets
. Large waterproof rear pocket, and zipped mesh rear pocket
. Rear hanging loop, rear net D-ring & 2 front & 2 side D-rings
. Front rod loop and Velcro tag. Plus Velcro fly patch
. All zips feature quick-pull Aztec pattern material tabs
Both models –
Colour: Sage Green
Sizes: M, L, XL, XXL
The Monomoy Jacket is a top quality wading Jacket with advanced design and technical features that the serious fisherman will appreciate.
We have spent a long time designing this jacket, and you will find some new features you have not seen in a wading Jacket before.
The Jacket is designed taking for granted it will be used in saltwater, hence we needed to redesign or remove all features that would not stand the use in saltwater. Our idea was that if we could make a great saltwater jacket, we would at the same time have made a fantastic jacket for the freshwater fisherman, as Salt is the big "enemy".
Some of the features we made was removing all the exposed zippers to the front pockets (they are always the first to jam due to salt). We used a clever Velcro solution instead - faster, stronger and lasting for many years. The main zipper is a waterproof Riri Storm zipper, the same type as we use in our Narvi waders - this zipper is build for saltwater!!!
Inside the jacket you will find our unique 100 % waterproof Phone pocket. Even if you fall and go under water, the phone will be safe...(how many phones have you killed this way by now????). The pocket is mounted with Velcro, so if you want to look at a map or make a phonecall, just pull the entire pocket off. You can handle the phone through the pocket and even talk. When finished just put the pocket back in place - clever and easy!
In the back you will find 2 pockets. The normal back pocket and a new "tube shaped" pocket. Have you even been irritated that you had to take the jacket off to get to your thermos bottle, soft drink or beer?? This tube pocket is made just for that. In there you can have a thermos ready at hand at all times without having to take off the jacket.
2 big size front pockets placed high for deep wading - Crossed Velcro closure for easy getting boxes in and out, But still secure the boxes perfectly
2 Slim pockets closed via clever Velcro system behind the main pockets.
2 Fleece lined Napoleon pockets placed high for deep wading
2 Big inner pockets behind the storm flaps
1 100% waterproof phone pocket
1 Main back pocket
1 "Thermos" back pocket
Waterproof Riri Storm® zipper
Double storm flap
2 pig tail retractors - deep model so they don't interfere with flylines
Roomy cut over shoulders for easy casting
Elastic adjustable cuffs
Advanced hood design with adjustments inn front and the back for perfect individual fit
Sizes from # M to XXL
Breathability: 3500-4000 g/ m2 /24 h. (Test method – ASTM 96)
Waterproofness: 20,000 mm (Test method – ISO 0811)


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Tremble Cleffs: Voice and Singing Therapy
Meets weekly on Tuesdays,1-2:15 p.m., except for the month of August. Singing is exceptionally good medicine; known to lift spirits while strengthening voices and facial, throat and swallowing muscles made weak by PD. The Spokane Tremble Clefs are led by music director Pam Baldwin, MA with Donna Douglass on piano.
- Where:
- Rockwood Lane Retirement Community, 2903 E. 25th Ave., Spokane, WA
- Neighborhood:
- South Hill
- Cost:
- Free
- Phone:
- (509) 443-3361
- Email:
- firstname.lastname@example.com
- Website:
- http://www.spokaneparkinsons.org/
- More like this:
- Senior, Support Group


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Blog Tour Stop: The Chronicles of Kerrigan by W.J. May- review
Nothing is as it seems anymore.
Leery from the horrifying incident at the end of her first year at Guilder Boarding School, Rae Kerrigan is determined to learn more about her new tattoo. Her expectations are high, an easy senior year and a happy reunion with Devon, the boy she's not supposed to date. All hopes of happiness turn into shattered dreams the moment she steps back on campus.
Lies and secrets are everywhere, and a betrayal cuts Rae deeply. Among her conflicts and enemies, it appears as if her father is reaching out from beyond the grave to ruin her life. With no one to trust, Rae doesn't know where or who to turn to for help.
Has her destiny been written? Or will she become the one thing she hates the most—her father's prodigy.


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Posts Tagged 'best restaurant in Clapham'
Our Clapham is Big, Our Pizzas are Grand
Whilst doing a little research into the history of Clapham I was a little taken aback by the following description from Wikipedia:
"Clapham has numerous public houses and several small shops; including a post office, Chinese and Indian takeaways, fish and chips, a florist, a hairdresser; also it has two churches. It has its own lower school for children aged 4–9, Ursula Taylor Lower School. In the nearby village of Oakley is Lincroft Middle School for children aged 9–13. It has three pubs, the Horse and Groom, the Fox and Hounds and the Star, as well as these there is also a club called "Clapham Club". There is also an Italian restaurant, Bellini's."
A post office? A florist? Two churches and one school?
And just one Italian restaurant?
It took a few moments for the penny to drop. Wiki is in fact describing another Clapham, this one in rural Bedfordshire. It would appear to be most famous for hosting the airfield from which the legendary band leader Glenn Miller took off on his last fateful flight, never to return.
Our Clapham, by contrast, doesn't have an airfield to call its own, although it is a reasonable travelling distance from Heathrow, Gatwick, Stansted and Luton. It has lots and lots of shops – florists, post offices, hairdressers – and churches and other places of worship of all denominations and faiths. It has many schools, and more pubs than even Oliver Reed in his prime could have visited in an evening.
And as for Italian restaurants, although it is not the only one in town Eco Restaurant's faithful band of regular visitors will tell you that it is the best restaurant in Clapham, indeed many swear that our fine team of staff serve what is in actual fact the best pizza in London.
It may be a bit of a hike from Bedfordshire, but we have the busiest train station in Europe so if any of our Clapham brethren should feel the call of pizza and Bellini's is closed there will always be a warm welcome for them at the Common.
Up The Junction
It was a famous 1963 book by Nell Dunn and followed up with a film version in 1968 starring a then very young Dennis Waterman alongside Susan George, Suzy Kendall and Maureen Lipman.
"The Junction", of course, was Clapham Junction, although the phrase "Up The Junction" went on to become a colloquialism for an unplanned pregnancy. Some years later the term lent its name to a hit single by the South London group Squeeze, who drew heavily upon the book and the film for inspiration.
Clapham Junction station is the busiest railway station in the United Kingdom, possibly in Europe, in terms of the number of trains that actually pass through – around 2000 on a typical day. About 12.5 million people either board or alight a train there each year.
For those of us who begin our journeys in West London and wish to head for the south of the country it provides a useful means of avoiding Central London, as the trains invariably stop at Clapham Junction en route having departed from Waterloo or Victoria.
It is alas a great shame that many of those millions who pass through the Junction will remain forever unaware of the presence of one of London's greatest pizza restaurants just a mile or two along the road from the station.
There are many good restaurants in Clapham, but none quite like Eco Restaurant, the home of the Clapham pizza. Eco's pizzas are specially created with a unique healthy base which is not only nutritious but is also designed to bring out the taste of the toppings at their very best.
Whenever you are passing through the nation's busiest railway station why not take some time out to come and visit the best restaurant in Clapham and partake of its legendary succulent and healthy offerings?
Plan your visit well in advance, and you'll not be left Up The Junction.


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March 21, 2005
Fried Pork Chops
4 cups vegetable oil
¼ teaspoon salt
¼ teaspoon black pepper
½ teaspoon garlic powder
4 pork chops (bone in)
1 cup buttermilk
1 cup all-purpose flour
Heat oil in a large, heavy bottomed pot to 350 degrees F.
Sprinkle the seasonings on both sides of the pork chops, rubbing them thoroughly into the meat. In a large bowl, dip pork chops in butter milk. Roll each chop into flour, and shake off the excess. Carefully place the chops, 2 at a time, into the hot oil, and cook until golden brown. Drain on paper towels before serving.
Key Words: buttermilk, pork, recipe
1 comment:
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Yoga was designed to be practiced with regularity. We invite you to practice three times a week or more, to see for yourself how this can positively impact all aspects of your life. In fact, we'll meet you halfway.
Introductory Deal ~ $30 for 3 classes (1-month expiration)
That's $10 a class…. now that's a deal. Check out our offerings and our wonderful teaching staff.
Monthly Unlimited ~ $129 per month, unlimited practice
We make this easy. Sign up anytime, no fees, no freezes, no commitments. Do the math! If you practice 3x a week, that's less than $10 per class.
Drop-in ~ $18
Express Class Drop-in ~ $14 (Express Class 5 class card $60, 2 month expiration)
5 Classes ~ $85 (2-month expiration)
10 Classes ~ $160 (3-month expiration)
Mat Rental ~ $2
Towel Rental ~ Free
For Ashtanga Membership and Pricing (Seperate program) click here.
New to Yoga? Click here.
Suitable for beginners as well as the experienced in search of a tune-up.
Yoga is so much more than just another workout, and this class will show you why. As you learn how to stretch, strengthen, and breathe properly so that your body can be at ease, you will cultivate the ability to meditate, and learn about the complete philosophy of yoga. The goal? To experience a comprehensive spiritual practice that will spill over into your whole life, making everything you do infinitely more enjoyable.
Suitable for somewhat experienced practitioners who are ready for vigorous practice.
Open level classes are for just about everyone with a fair amount of experience with yoga, all the way up to the advanced practitioner. Expect a vigorous vinyasa flow with intelligent alignment instruction and options to take the poses deeper or ease back, depending on your skill level. Your body, your breath, your practice: you know it better than anyone. Get into it.
Intermediate/Advanced (Int/Adv)
Suitable for intermediate to advanced students who know when to hold back, and when to go for it.
Int/Adv classes offer a highly vigorous and challenging practice to seasoned practitioners who are ready for deep physical and mental exploration. Sweaty vinyasas, teachers dripping with liberating insight, meditation, pranayama, chanting, and beyond. Expect all of the elements of an Open class, and expect the unexpected.
Express (Open level, 65 minutes)
Transform your busy day at light speed! These Open level classes offer a vigorous practice that is modifiable to meet your skill level. Express Classes are a steal at just $12, but you are welcome to use the classes stored on your account or Monthly Unlimited.
Restorative (Open level, 75 minutes)
Ashtanga ~ Led Class (Intermediate /Advanced)
These classes are for students and teachers interested in deepening their understanding and practice of yoga. For those considering a Mysore practice, the led classes are also a wonderful introduction into the Ashtanga yoga system. Students will be guided through Yoga Chikitsa (Yoga Therapy) to the rhythm of the vinyasas counted in Sanskrit. This primary series of Ashtanga yoga is taught in the traditional method of Mysore, India by Shri K. Pattabhi Jois. There are no classes on new or full moons (moon days).
It is said that meditation does from the inside what yoga does from the outside. Both our meditation classes, Dharmapunx Williamsburg Meditation (Sundays at 6pm) and The Mindfulness Sessions (Saturdays at 4pm), offer accessible Buddhist meditation instruction that is suitable for all levels of practitioners. These classes are 90 minutes and include guided meditation, lecture, and group discussion on topics relevant to incorporating the principles of meditation into everyday life. No experience with meditation is necessary!


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AUSTIN, Minn. — Hormel Foods Corporation (NYSE: HRL) today announced the closing of its acquisition of Columbus Manufacturing, Inc., an authentic, premium deli meat and salami company, from Chicago-based Arbor Investments. The addition of the Columbus® brand further strengthens Hormel Foods' position as a total deli solutions provider while enhancing its other strong deli brands such as Hormel®, Jennie-O®, Applegate®, and Di Lusso®.
The purchase price is approximately $850 million. Total annual sales are approximately $300 million with an expected growth rate in excess of 5 percent. Hormel Foods expects this acquisition to be modestly accretive to earnings per share in fiscal 2018.
"The acquisition of Columbus is the catalyst for uniting all our deli businesses into one group," said Jim Snee, chairman of the board, president and chief executive officer. "We received regulatory approval faster than anticipated and are excited to start building a stronger, more united deli organization."
Subsequent to the closing of the acquisition, Hormel Foods is increasing its fiscal 2018 net sales guidance to $9.7 – $10.1 billion and increasing its earnings per share guidance to $1.62 – $1.72 per share.
ABOUT HORMEL FOODS – Inspired People. Inspired Food.™
Hormel Foods Corporation, based in Austin, Minn., is a global branded food company with over $9 billion in annual revenues across more than 80 countries worldwide. Its brands include Skippy®, SPAM®, Hormel® Natural Choice®, Applegate®, Justin's®, Wholly Guacamole®, Hormel® Black Label® and more than 30 other beloved brands. The company is a member of the S&P 500 Index and the S&P 500 Dividend Aristocrats, was named one of "The 100 Best Corporate Citizens" by Corporate Responsibility Magazine for the ninth year in a row, and has received numerous other awards and accolades for its corporate responsibility and community service efforts. In 2016, the company celebrated its 125th anniversary and announced its new vision for the future – Inspired People. Inspired Food.™ – focusing on its legacy of innovation. For more information, visit www.hormelfoods.com and http://csr.hormelfoods.com/.
This news release contains forward-looking information based on management's current views and assumptions. Actual events may differ materially. Please refer to the cautionary statement regarding Forward-Looking Statements and Risk Factors which appear on pages 32 – 39 in the company's Form 10-Q for the quarter ended July 30, 2017, which can be accessed at www.hormelfoods.com under "Investors-SEC Filings."
Source: Hormel Foods Corporation


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// Home / Galactic Codex / Bring Down The Sky /
Expand Your Mass Effect Experience in the first ever downloadable content for the award-winning saga the New York Times named "The Best Game of the Year".
A batarian extremist group has hijacked a mobile asteroid station in the Asgard system, setting it on a collision course with the nearby colony world of Terra Nova. Only you, and the hand-picked crew of the Normandy, can save the millions of innocent civilians before the asteroid completes its deadly descent.
This first downloadable content pack further expands the Mass Effect universe and continues the adventures of Commander Shepard and the Normandy crew.
Download the content pack for your Xbox 360 or PC, then either open a saved game where you have access to the Galaxy Map onboard the Normandy, or you start a new game and play until you are given use of the Galaxy Map.


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The Homes and Communities Agency (HCA) is the national housing and regeneration agency for England. It was formed in December 2008 from the amalgamation of English Partnerships, the investment arm of the former Housing Corporation, and the Academy for Sustainable Communities.
The HCA is responsible for major delivery programmes for the Department of Communities and Local Government and its role is to create opportunity for people to live in high quality, sustainable homes by providing funding, on behalf of Government, for affordable housing. The HCA also aims to bring derelict land back into use and by doing so improve standards for the physical and social environment.


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There are a few classic Italian cocktails, the Negroni is on that short list. It's said to have originated in Florence as a twist to the Americano cocktail. It's an aperitif which is meant to be enjoyed prior to dinner to stimulate the appetite {not that I have any problem with that}. And while I was in ROMA recently we did just that.
I think I lost count how many I enjoyed over the course of my trip after the second or third ; ) There's just something magical about sipping a Negroni at a quaint Italian ristorante {like the one pictured below} waiting on your meal to arrive, people watching, chatting with your friends about the days goings on. It's a perfect beginning to your meal.
I enjoyed them so much that when I returned back to
reality ehem home I had to pick up a bottle of Campari straight away so I could re-create those delicious drinks at home.
What you'll need:
2 ounces gin
2 ounces sweet vermouth
2 ounces Campari
orange slices to garnish
What to do:
1. Into a cocktail shaker filled with ice cubes add: gin, vermouth, campari and shake until chilled
2. Equally strain mixture between two low ball glasses that are filled with ice.
3. Garnish with orange slices.
19 Comments
Sounds delightful! I'll have to pick up the ingredients, as it sounds like the perfect summer drink.2
I have never had one of these. Will have to get the ingredients.3
Non vedo l'ora del negroni (fantastiche foto, btw)…parto la settimana prossima per Roma: evviva!!!4
i almost ordered a negroni the other day and got scared because i've never had gin! yours looks so beautiful, methinks i'll be ordering next time 🙂5
I've been really curious about this drink. So glad you posted a recipe for it 🙂
I can just see you, sitting at a table in Roma, sipping on this and chatting away…ahh, wish I was there with you 🙂6
Sounds like the perfect light and refreshing way to start your meal to me!7
I'm with you – I don't need anything to help stimulate my appetite (quite the opposite, actually) but this sounds like a delicious cocktail to try!8
Oh yum! Paula, do you think Aperol would work well in place of Campari here? I have an entire bottle of it from making my Sparkling Acres cocktail, and I'm wondering if this would be another great way to use it.9
I'd love to have a Negroni sitting at that ristorante in the photo. What a nice time you must have had in Roma!10
I'm looking forward to sipping on this. Sounds so good!11
Move over and make room for me at the bar. GREG12
I'll take Campari any way I can get it! You're on!13
Your blog is going to lead me into alcoholism…
Okay. I probably shouldn't joke about that. But seriously, these and the nutella shooters? Yum!14
Such a yummy drink. Yum!15
Tis the season! Cheers.16
My Dad's favorite drink! I like it to, of course… 🙂17
Love this drink and these photographs! Salud!18
my husband and i went on a trip to rome last summer. I would say we had 1 or 2 or maybe 10 of these 😉19
Personally I prefer mine stirred not shaken and with rind twisted over the top to release the oils. One of the things I like about this drink is the amazing variation you can get using different brands of sweet vermouths and gins. I'd highly reccomend Brokers Gin with Rosso Antico Formula
- Thirst Quenchers | She Wears Many Hats - [...] Negroni from Bell'alimento [...]
- Cheers to a New Year's Eve Party | bell' alimento - […] and Prosecco Cocktail Frozen Peach Bellini Very Berry Bellini Cham-Pom Spritzer Champagne Slushi Negroni Raspberry Clove Club Cocktail Sparkling…
- A Spicy Perspective POG Punch - A Spicy Perspective - […] Negroni Italian Cocktail ~ Bell' Alimento […]
- Italy on a Plate - The Week in Italian Food: June 12, 2011 - Food Lover's OdysseyFood Lover's Odyssey - […] Negroni – Paula makes the classic Italian cocktail – Bellalimento […]
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So it's safe to say that it's really no surprise that EDGE has become quite a powerhouse among local foodies and tourists alike. The food is consistently good, the drinks are solid and the service is great. The question would then be, does their Miami Spice menu capture that? The answer is an unwavering "hell yeah".
|Edge of the Moon
|Mahi Mahi
|Cherry Bomb
|Peanut Butter and Jelly
This is definitely a Miami Spice must-do for 2013 and I highly recommend it. Their Miami Spice menu has a lot of varied options and it is an excellent representation of the superb quality of their full menu. For more information on EDGE Steak & Bar, visit their website at


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Apple Pay to Get a Helping Hand in Europe By Visa
The mobile payment technology launched by Apple Inc. in the fourth quarter of 2014 is slowly but surely becoming a prominent player in the payment system in the United States. Now, the payment system is bound to get a boost in the European market, thanks to Visa Europe, perhaps the most famous payments business located in the region with operations running all over the world.
According to recent reports released by Visa Europe, the company is on the road to equipping its European terminals designed to facilitate contactless payments with the feature to support the tokenization technology.
Coincidentally, this tokenization technology is also the same used by Apple Pay and Google Wallet, hence this comes as great news for both the mobile payments systems, especially Apple Pay, which is newer and has more reach than its Google counterpart.
The incorporation of the tokenization technology in the region's contactless payments units will culminate by the end of April 2015, according to verified reports by Visa Europe. However, no exact date for the completion of the project has been given out by the company.
Visa Europe is at the forefront for bringing in technology that revolutionizes mobile payments system in Europe, and that is exactly what the company is doing by bringing in the tokenization technology to its infrastructure. Tokenization technology is considered by experts to be the best method of data protection and also the best remedy against mobile payments fraud.
The current system in play at the contactless terminals in Europe is a direct one, one that communicates the actual card details to a terminal whenever users carry out a transaction. This is dangerous, as it leads to credit card frauds and identity thefts.
Apple Pay, on the other hand, has incorporated a tokenized system in its mobile payments system by allocating single-use codes to cards for every transaction conducted, codes that can be traced back to the actual cards by card companies to complete the transaction. This results in a highly secure environment for mobile payments. This is also currently only available in the United States.
However, Visa Europe is now on its way to bringing in a more secure environment to the European market for contactless payments as well. Competitors of the company, MasterCard etc., will surely follow in this respect.
As far as launch of Apple Pay in Europe is concerned, the inauguration of the tokenization technology at Visa terminals in Europe does not guarantee the launch of the service in the continent. In fact, no such announcement has yet been made by Apple Inc. But analysts over at some European banks have been quick to make a sure estimate of the launch date, and they peg the launch of the Apple Pay mobile payment system in Europe no later than Q2 of this year.
And a deal seems to have already been finalized by Apple with Visa regarding the amped up infrastructure. According to Steve Perry, a spokesman on the matter, Apple and Visa have already reached an agreement in this regard. This means Apple Pay can be expected to launch in Europe very soon.


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The United States (US) is currently witnessing what can only be described as a day of reckoning. It has finally reached the point where it cannot borrow more money without the approval of all levels of the federal government. Sure it has been here before, but this time is different. There is a certain realization, driven home by the bond rating agencies and the recent stock market crash, that the US must face reality - it has financially outlived its welcome in the global sense. The concept of borrowing based on a national worth that exists based primarily on grossly inflated paper equities came to a sudden breaking point in 2009.
The US reacted to the stock market collapse by injecting massive amounts of borrowed money into the economy - commonly known as "The Stimulus". That money was borrowed from international players, such as China, who do not necessarily have the US's best interests at heart. The US gambled that a massive infusion of new borrowed dollars would spark the economy and kickstart consumption. It didn't work. There is an obvious reason why. The US as a nation and a people have come to the point where there financiers are going to call their loan. They have been living far beyond their means, consuming far beyond what they contribute in production, and expanding internationally far beyond their ability to sustain.
They now must face the abyss. There are only three ways to reduce and eliminate deficits - raise taxes or cut government operations, or normally both. We in Canada know this already. We did it back in the 1990's. The Americans are having a hard time bringing themselves to believe that they must bite the bullet like ordinary mortals, and pay the piper. There are of course many signs this will happen whether they like it or not: end of the space program in many ways; potential down grading of credit by international bond agencies; loss of clout to the Chinese internationally; and so on. The signs are all there, and should the US politicians continue their silly dance to avoid responsibility with their electorate the market will push them into place.
Here in Newfoundland and Labrador we face the same sort of questions - just not with the same, imminent urgency ... for now. We have an oil industry to draw from for the interim. We have mining activity. The problem is we are spending every cent as it comes in. Not unlike a child that receives an allowance and then runs to the store to spend every last cent - until next weeks allowance comes. We are not reducing our debt. Our gross debt continues to grow. Most governments count their debt as "net debt" meaning essentially minus the value of assets from gross debt and what is left is net debt. Unfortunately, this is not an accurate or sensible way to account for debt and strategic direction.
To put it another way, it would be the same as saying your house is worth $200,000 and your mortgage is $180,000 therefore you owe only $20,000. Of course that isn't rue, but on paper your net debt would be that $20,000. This is the same sort of accounting that created the financial disaster in the US. The mentality that inflation will increase the value of your asset forever more, and you can borrow against that "paper equity". The leveraging of debt upon debt. The house of cards. The old saying though is 'its only worth as much as somebody else is willing to pay for it'.
In this province our government continues to spend as if those assets it has put up to bring down its debt numbers are actually worth a whole bunch on the market. Everything is included from the value of schools, hospitals, etc. A big disadvantage we have compared to other provinces is the simple fact that most of our Crown resources/corporations have already been privatized. We do not have any real crown assets to put up as collateral other than Nalcor. The insurance industry is privatized. The liqour industry is primarily in private hands. The power industry, retail branch, is privatized. In other words our assets to borrow on have been well and truly mortgaged many years ago.
Now we face a strategic decision of whether or not to incur a massive new debt to our already troubling numbers - mainly the $6.5 billion Muskrat Falls project. Should we add 50% more to our debt? Will the international community allow us to without a federal loan guarantee? Should they even then? Is it not more prudent to borrow $600 million to renovate and improve the Holyrood facility. Would that not hold us over until a decade or so down the road when we can assess whether or not we really need the extra power, and if so by then we may have eliminated our debt putting us in a much stronger financial position vis-a-vis the rest of the world to borrow.
Last week the President of Nalcor came on the provincial openline radio show. He spoke of the debt for Muskrat Falls. His explanation was the debt wasn't really $6.5 billion. He said that Emera was paying for the link so you could take off $1.2 billion from that number. Then he said the provincial government was taking an equity position of 35%, so really the cost was more like $3 billion. Note to the President of Nalcor - you are a Crown corporation. We own you. We are also responsible for your debt. How can a provincial government take a 35% equity position in a crown corporation's project that it owns 100%? Course its spin doctoring, but the worrying part is the lessons not learned. In this case the lessons blindingly ignored. We are not immune from economic reality. The very real disaster occurring to our south in the US could just as easily occur right here.
That leaves us with a very crucial provincial election in October. Not in any way a typical election. This election is about the future strategic direction of the province. Will it be debt ridden and vacated, or will it be debt free, confident and bright? It's all about the debt, and that makes it all about our destiny.
Here's to the crazy ones, the misfits, the rebels, the troublemakers, the
round pegs in the square holes... the ones who see things differently -- they're
not fond of rules... You can quote them, disagree with them, glorify or vilify
them, but the only thing you can't do is ignore them because they change
things... they push the human race forward, and while some may see them as the
crazy ones, we see genius, because the ones who are crazy enough to think that
they can change the world, are the ones who do.
Steve Jobs
US computer engineer & industrialist (1955 - 2011)
Monday, July 25, 2011
Debt and Destiny
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Besides academic rigor and critical thinking another thing … just as important … is drilled into the heads of every young man attending the University of Detroit Jesuit High School and Academy … community service. It's a mission and a commitment that serves our city well.
Every one of the 900 young men attending U of D Jesuit spent today (October 6) sprucing up Fort Wayne and Belle Isle landmarks and serving at Cass Community Social Services, Gleaners Community Food Bank, Palmer Park, St. Paul Retreat, and St Raphael Orthodox Church. That's the entire student body.
It's part of the school's annual student-led service project called Pledge Detroit. Now in its sixth year, it consists of students, faculty, staff, parents, and alumni.
"Pledge Detroit continues to be an exciting, student-led initiative which allows our students to live out our school motto, 'Men for Others'", says U of D Jesuit President, Fr. Karl Kiser, S.J. "With service to the community being an important aspect of the unique student experience at U of D Jesuit, what better way for our students to demonstrate their commitment to the community than to give back to the city where U of D Jesuit has resided since 1877."
Pledge Detroit is the school's approach to student fundraising. Instead of asking for money or selling raffle tickets, students collect pledges for student activities and co-curricular programs. In return the students clean up and volunteer.
This year, more than 5,000 man-hours will be donated towards cleaning up Detroit, with the work being done between 8:45 a.m. to 12:45 p.m. at various locations. Since its inception, the U of D Jesuit community has given almost 30,000 hours of service to Detroit through its Pledge Detroit initiative.
Pledge Detroit is just one of the many community service activities students participate in during the year. They are also involved in weekly Senior Service program at schools, hospitals, hospices, and centers for the aged and less fortunate, monthly Focus: HOPE food delivery service to the elderly, an annual collaboration with Gleaners Food Bank and its "Mountain of Food" competition, and a pallbearer service for the marginalized and homeless veterans.


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Teppanyaki Ice Cream At Millennium Hilton
Ice cream and Teppanyaki are two words we never thought would go well together. In our minds, teppanyaki is a Japanese way to grill meat, seafood an veggies on a burning hot metal surface, so it was weird trying to visualize someone dropping a melting scoop of ice cream onto a grill. But the stranger the idea, the more we want to try it, so we crossed the river to reach 'The Lantern', a creative ice cream shop located at the foot of the Millennium Hilton hotel. It's very easy to get to and the beautiful view of the Chao Phraya river is one more reason to give it a try.
The Lantern is entirely dedicated to chocolate in its many forms and to ice cream as an art, not just a snack or a little casual treat. With a very high ceiling and comfortable sofas inside and outside on a river terrace, it can look a bit intimidating; and you can't help but wonder, is it going to be just a fancy and sophisticated ways to prepare what at the end will still just be... an expensive ice cream?
On the first visit, the most tempting place to sit and enjoy the experience is of course around the teppanyaki counter, the way you would do in a Japanese restaurant, just to satisfy your curiosity. It will come as a reflief to find out the the teppanyaki is actually a frozen metal surface rather than a sizzling grill. Hanging above the counter, a dozen glass jars containing sugar and chocolate toppings are here to remind you that no meat is about to be cooked here.
When the menu is presented to you, the complexity of the mix can be confusing, so the best way is just to pick one of the three signature ice creams:
- Frozen Sacher Ice Cream: Waffle basket, Grand Cru Maracaibo 65% ice cream, poached apricot, fudge brownie, Edelweiss ice cream, fresh raspberries, fresh whipping cream.
- Warm Berries with Grand Cru Chocolate Ice Cream: Edelweiss ice cream with chocolate terra, Elvesia chocolate ice cream with caramelized almonds, aged balsamic flavored berrie, swiss meringues, caramelized almonds, orange snap.
- Sticky Chewy Grand Cru Chocolate Ice Cream: Maracaibo Criolait ice cream with brownie, Maracaibo chocolate cheese cake cubes, Edelweiss chocolate ice cream, Marshmallow, Bourbon vanilla sauce, caramel sauce, caramelized hazelnut.
If you happen to know a bit about chocolate origins and qualities, you start to get the first clues that this isn't going to be just another fancy mix. But spas also have overly-complicated names for what ends up being just another way to massage you, so it's with great interest that we started to scrutinise and then admire the skilful way the ice cream sommelier (that's probably an appropriate way to call her) mixes the many ingredients on the frozen surface. It doesn't take very long and soon it's the moment of revelation... is the 260 baht just for show or is is going to be a blast?
The verdict is clear, this is no ordinary ice cream, it's something beyond anything we tried before, and we've tasted a lot. It's not so much about the Teppanyaki process itself, which is just a logical and practical way to efficiently mix the ingredients while keeping them at the right temperature. In fact you can even find teppan ice cream in local Thai markets nowadays. Here, it's all about the unique quality of the ingredients, the subtle proportions and the creative way they have been selected. Take another minute to look at the menu again and you will see.
Even if you are no ice cream or chocolate connoisseur, this is a new experience and even those who are not big cake or sweet fans will enjoy this treat by the riverside. It's the kind of place you want to tell your friends about, and then come back with them!
Open: Daily from 7 am to 10 pm
Getting There:
by taxi only
Millennium Hilton Bangkok hotel
click for view map


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Your Mississippi Sports Hall of Fame and Museum is a non-profit organization that operates without tax money from any level of government. We do so, thanks to generous corporate support, the many fund-raising events we have established and through memberships. How can you help? Glad you asked. You can become a member at several different levels, including:
Individual $25
-Annual free admission
Family $100
-Two free admission passes per year


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Hey Hey,
Just a quick update to let you know what we are up to! After a long travel day Saturday and Sunday we arrived back in good old lively Durham, MA and jumped into laboratory work and analysis time! It was sad to leave Abisko and take down our flagging tape and pack everything up, but as one of us in the group likes to say "It's never 'goodbye' it's 'see you later'!
To finish up the program we are creating posters to present next week at UNH, submitting abstracts to the American Geophysical Union to see if we could present our posters in their fall meeting. It is hard work and sometimes stressful but we are all making the most of our opportunities here to gain more laboratory and data analysis experience so there is something new to learn each day.
The summer days here are still unpredictable as always with hot humid days and rainstorms alternating. In this heat we often find ourselves pining for Sweden's clean dry air and crisp temperatures. I for one, even miss the cold mornings.
Anyway, all of us are pretty wrapped up in our projects, but hopefully we will be able to show off some more of them on this blog in the remaining week.
Cheers! <—-learned this phrase at the London airport.


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An EDSL for KDB/Q
Slides for the Haskell Exchange 2017 talk.
Functional pearl: Nested Datacubes
Multi-dimensional aggregation and grouping using nested datacubes in Haskell.
Map Comprehensions
An idea for a useful indexed monad: the map comprehension.
The Essence of Compilation
A toy compiler and virtual-machine in less than fifty lines of haskell.
Fixing GADTs
Generic recursion schemes for GADTs using fixed points of higher-order functors.
First post
A new blog on applied functional programming.


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Community Action Fareham works with over 500 voluntary and community groups in the area and has the resources to help in most situations.
From committees and constitutions made easy to model policies and fact sheets, we have the experience and expertise to give you the help and advice you need.
Here's one called "Basic Checks for Community Groups and Charities"
Community Action Fareham can provide guidance and support to community and voluntary groups on the following:
- Funding
- Promotion
- Training
- DBS Checks
- Administration
- Equipment loan
- Community transport
- Network lunches
- Speakers for groups
- Meeting places
- Pop-up gallery
- Health forum
And if we cannot give you the answers, we will let you know who can.


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offer autoradio,one din 4.3 inches car dvd player
Supplier Details
Xin Yuan electronics technology co,.ltd
Free Member (2011)
[ Shenzhen, GU, China ]
Business Type: Manufacturer
Supplier has 1,729 products
Quick Details
Packaging and Delivery
Product Description
One din 4.3 inches slide down car dvd player
DVD/VCD/MPEG4/MP3/CD/CD-R/CD-RW Compatible
Touch screen Control
Motorised and detachable Front Panel
Built in Bluetooth
With Analog TV tuner (PAL/NTSC /SECAM compatible)
Built-in AM/FM tuner, 30 Station Memory
Support MMC/SD/USB Drive for direct playback
Aux on the front panel for A/V output
4X50W Max. MOSFET Amplifier
Anti-Shock mechanism
Rearview camera input
Parking detective system input
RCA Line Out
Remote control
GPS Navigation (Optional )
Digital TV ,RDS (Optional )
Basic Information
About Us
Xin Yuan electronics are one of prefessional manufacturer ane exporter of car audio player in china. we have been in the business field for 7 years .strick QC and experienced workers keep our products on the high quality side .Since 7 years development , our clients are all over the world .but most of them come from european and american countries, whom take a successful in their market .if further info about us , please feel free to contact us .
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