text:
Today, something very special. This post is going to be a two post in one, aka a 2fer. Two great and related stories need to be told.
Last night, I actually got to turn on the TV and put it on a news channel. That is a rare and wonderful thing for me, a news channel junkie. The US ship captured by pirates was the story on at that time. The big one looked at me and ask "Are pirates real?"
"Yes. Pirates are real."
"Like Captain Hook?"
"Well, no. Not exactly, like Cptn Hook, but there are real pirates. These pirates captured a US ship."
"Oh wow." said with a look of disbelief on her face.
"Everything is ok. The crew got their ship back, and there is a US Navy ship there to protect them now."
"A Navy ship like my daddy's?"
"Well, sort of."
"You mean my Daddy is fighting pirates?"
"I guess he could be." I mean, it is possible, how ever not likely.
"Oh man! That means my dad is fighting Captain Hook!! Wait! That means my Dad is Peter Pan! My dad is Peter Pan!"
She was thrilled with her realization, and danced all around the room yelling that her dad is Peter Pan for at least a couple of minutes.
At this point, I couldn't respond. I was too busy trying to hold it together. I was laughing, but I wanted to be crying and laughing it was so good. If you had seen the sheer look of conviction on that child's face the moment she decided that her Dad was Peter Pan, you would have lost it, too. It was priceless.
Now, on to part two of our pirate tale.
Later on, my mom was telling my sister, whom I have mention before, about The Big One's epiphany. She only got to the part with the news story and Sis stopped her.
"Wait. You mean there are real pirates?
Seriously. My sister just ask if there were real pirates. I swear. My mom told her of course.
"You mean like Johnny Depp? Real pirates?"
No really. She ask.
My mom went on to tell her it was all over the news, and tell her about them. I love my sister, and I think this is more proof positive that somehow, my daughter is just like her.
To make the tale even better, Sis was out to lunch with a friend of hers who is from Sierra Leone and the friends mom. The friend came to the USA in order to go to college. She is very intelligent, speaking multiple languages,with multiple degrees. You know, a nerd. Sis starts to tell the tale of the pirates, and gets to the same point in the story as my mom did, and her friend stopped her.
"Wait. You mean there are real pirates?"
My sister was thrilled. Having someone that she considers uber smart echo her same questions seemed to give her some sense of validation, and that she wasn't that off for not knowing that pirates still existed.
I was discussing this with her, and she assured me that she could go out and find 10 people she knows that didn't know there were rel pirates now. I assured her that was not necessarily a good thing. Her parting line, and the line that I let finish the conversation because I couldn't take any more, was "I'll be honest. My friends and I care more about our hair than pirates." Right on. As long as you know who you are, and are proud of it. You just keep on, keeping on.
Love you, sis and thanks for the great stories to post.
Thursday, April 9, 2009
Peter Pan and the Pirates - A 2fer
Today, something very special. This post is going to be a two post in one, aka a 2fer. Two great and related stories need to be told.
Posted by Morada at 2:25 PM
Labels: family, funny, lessons, my daughter


text:
Phew, now that we're done giving up our weekly blog spot to guests to talk about ISP Spotlight we're back into our weekly round-ups of Internet access, use and security stories that have caught our eyes recently.
But first... UN recognises human rights apply on the Internet
Before we get into all of that, we wanted to highlight something that happened a few weeks ago (sorry). The UN's Human Rights Council has realised the brilliance of InternetNZ's policy principle "Human Rights should apply online" and said yes - human rights do apply online. The resolution "The promotion, protection and enjoyment of human rights on the Internet" did cause some controversy (and probably has nothing to do with us). Anyway, we think the UN getting onboard with the idea that human rights apply to humans regardless of the information communications technologies they use is excellent.
Chips with Everything, a tech podcast from the Guardian, has started a 5-piece series about human rights and the Internet which I'd highly recommend you add to your podcast to-do list.
Also, our speaker series next month Harrassment and the Internet will cover a lot of the free speech vs harmful speech issues. Register here
The FCC and city-run broadband in the USA
In the states, apparently there are city councils that are running broadband services - presumably to compete with the large, integrated ISP like Comcast & Verizon.
As is often the case in the US, the big guys got their lobbying shoes on and a number of states passed laws stopping, or constraining, local government from offering broadband (including fibre services). The Federal Communications Commission (the FCC) stepped in and made a ruling protecting councils' rights to offer competition.
One of our policy principles is that Internet markets should be competitive, so it's disappointing to hear that the FCC has lost an appeal against its order in a federal appeal court. I'm pretty confident the FCC will appeal, their Chairman has been a surprisingly strident protector of consumers and competition.
This is another case that makes me rather happy we have our structural separation between Chorus and the retail ISPs here in NZ. Our city councils don't need to get into the ISP game (they can leave that to the newspapers) to create competition.
- Engadget: FCC loses municipal broadband appeal
- Engadget: FCC protecting city run broadband
Google's emergency services solution
Google have announced a new feature in Android that lets you send your location data straight to emergency services. I know it sounds a bit niche but this is actually a big issue.
Here in NZ something like 70-80% of 111 calls are from cellphones and the location information isn't directly, instantly, available. Basically, the networks are not configured to easily and quickly let the emergency services call centre know where you are (and where the help is needed). That's a cause for concern as lots of people struggle to give accurate location descriptions (especially if you've come across an accident / are on a street you're not totally familiar with).
Google's feature is cool and it's already being trialled in the UK & Estonia (of course Estonia's trialling it).
What are we doing here? I'm glad you asked. Rather than addressing the network level issues (quite expensive), MBIE has commissioned an app for people to download and use when calling emergency services. There's plenty of opportunity for this one to go wrong (writing apps is easy, writing secure apps is harder) but it's not out yet, but watch this space!
- MBIE information about emergency call services
- Beehive Press release: new 111 smartphone app to be developed
Oh Australian online census. How should we describe you? By the sounds of if "omni-cluster-shambles" is the best descriptor.
Last week Australia tried to run its five yearly nationwide census. Most users were expected to fill in their forms online, there were even TV adverts telling people this. But on the night, users found the census website inaccessible. Out of nearly 20 million Australian residents, only about 2 million forms were filled in. Social media was filled with people saying they tried repeatedly, and crashes part way through meant their data was lost. The Australian Bureau of Statistics has said that the system was under attack by outsiders. They have suggested that there were repeated Distributed Denial of Service (DDoS) attacks. The people running the service decided to take it offline, as DDoS attacks can be a distraction to enable stealing data from the system.
Essentially, from reports we're seeing out of Australia, it sounds like the Australian Bureau of Statistics (who run the census) and IBM really stuffed this one up. Sounds like they should have taken more advice from StatisticsNZ which offers an online census option. There are probably some lessons here. Firstly, if you need something on the Internet to be used by lots of people within a small time frame, you'd better have DDoS protection in front of it. That's just the reality of how we have to roll now (you can't leave your car unlocked these days either). The second lesson is that for important processes like censi (sp?) and elections... we probably want to take the move to online a little more carefully. "She'll be right" doesn't cut it.
- Risky Business: What I've been told about #censusfail
And final word on this goes to @liamosaur
The best thing about #CensusFail is we'll never again have to hear the phrase "Nobody ever got fired for buying IBM"
— Liam O (@liamosaur) August 11, 2016
That's it from us this week. Have an awesome week and be excellent!

subset: commoncrawl


text:
The final of a competition for talented young musicians in the Harborough area were the most tightly-fought in the contest's six-year run.
Great Bowden Recital Trust's Junior X Factor contest reached its conclusion at Market Harborough Congregational Church's Jubilee Hall in Bowden Lane on Friday night.
Overall winner was singer Lily Ingall.
The final followed heats for different age groups earlier this month at Great Bowden Village Hall on the weekend of March 13 to 15.
It was described by the organisers as more "tightly-fought than ever before".
The contest and tickets for the final were both free and the event is now the largest and most established music competition for young people in the area.
It was open to all young instrumentalists and vocalists from school years 1 to 13 who live within 15 miles of Market Harborough who either performed as soloists or with a group.
After listening to one entrant every seven minutes for more than eight hours during the heats earlier in the month, the judges Andrew Cartwright, Kathryn Cartwright, Debbie Smith and Ryan West awarded 11 of the acts the opportunity to compete in the finals.
Chairman of the recital trust Mr Cartwright said: "The standard is usually extremely high in this competition but this year saw all of the finalists step up to the mark even more than ever before.
"It was a phenomenal evening showcasing the breadth and depth of the huge amount of young musical talent that Market Harborough has to offer – we can't wait until next year. The audience was staggered by the high level and confidence of every single one of the finalists."
Each of the finalists were assessed for the communication of their piece, performance, technique and accuracy and must have been awarded 80 per cent or more by the judges in the heats to earn themselves a place in the Finals.
"All the finalists had prepared well, thought long and hard about how best to communicate to a full capacity, hugely appreciative audience and performed superbly throughout the evening," added Mr Cartwright.
Each heat winner was presented with £50 of vouchers kindly donated by town music shop MH Music of St Mary's Road.
The overall winner was presented with £100 of vouchers and a glass engraved trophy with the runners-up and third-placed finisher also winning trophies. And the most promising performers received funding for six months of music lessons funded by the recital trust.
MH Music shop owner Matt Hankins presented the certificates on the night.


text:
Login | Join | Contact Us
Why create a free account?
Member Benefits
Forgot Login
Why create a free account?
Member Benefits
Forgot Login
The pill mill doctor who prescribed thousands of opioids and billed dead patients
Final defendants in multi-million dollar health care fraud and money laundering case sentenced to federal prison terms
Kindred pays feds largest penalty ever recorded for integrity agreement violations
Mylan investigations mount as West Virginia opens fraud probe
Skilled-nursing facility operator, execs pay $30M over improper Medicare, Tricare billing
Former owner of Lake Whitney Medical resentenced
Audit says home health care companies overbilled Mass. Medicaid by $23m
OSHA issues new guidance on settlement approval in whistleblower cases
UConn Health pays over $180k in settlement for overbilling allegations
News of Interest
The Hill: "Health Care Fraud: Criminal Prosecution Necessary But Not Sufficient" READ MORE
The New York Times: "Wells Fargo settlement raises questions on disclosure" READ MORE
DOJ: Assistant Attorney General Leslie R. Caldwell Delivers Remarks at New York University Center for Cybersecurity READ MORE
OIG: Video Series Eye on Oversight: Provider Self-Disclosure Protocol READ MORE
OIG: Proposed Rule: State Medicaid Fraud Control Units READ MORE
Insights from the SCCE/HCCA Blog
Undermining corporate self-policing
Those of us in the compliance and ethics field are believers. We believe companies should have effective compliance and ethics programs to fight all kinds of corporate crime and misconduct... But there is a nasty little secret behind this conclusion. The legal system, which is supposed to help prevent business crime, actually undermines company compliance efforts in some very serious ways. READ MORE
Patient privacy and drug diversion by healthcare personnel
When personnel divert controlled substances within healthcare facilities, it is vital to consider the potential for patient harm. We often think of harm in terms of physical injury, but there is one type of patient harm we often don't consider, namely patient privacy. READ MORE
The pill mill doctor who prescribed thousands of opioids and billed dead patients
On September 22, 2016, The Washington Post reported, "A former Michigan doctor who ran a pill mill for 16 months, distributing tens of thousands of narcotics and controlled substances to people who didn't need them for medical purposes, has agreed to pay $200,000 to settle a federal lawsuit that accused him of, among other things, falsifying records to charge dead patients, subjecting patients to unnecessary tests and billing for office visits that never happened.
"The settlement was announced Wednesday, amid National Heroin and Opioid Awareness Week, and came nearly four years after Hussein Awada, 46, was accused of defrauding Medicare, Medicaid and Blue Cross Blue Shield of about $2.3 million. He was charged in December 2012 of unlawful distribution of a controlled substance and conspiring to commit health care fraud. Awada pleaded guilty and was sentenced last November to seven years in federal prison." READ MORE | DOJ
Final defendants in multi-million dollar health care fraud and money laundering case sentenced to federal prison terms
On September 21, 2016, the U.S. Attorney for the Central District of California Eileen M. Decker announced, "With the final defendant receiving a prison term yesterday, six defendants who participated in a multi-million dollar health care fraud scheme or helped launder the illicit proceeds have now been sentenced to federal prison.
"Edgar Pogosian, also known as 'Edgar Hakobyan,' 32, of Glendale, was sentenced yesterday to 18 months in prison. Pogosian was found guilty earlier this year of conspiring to commit money laundering and one count of money laundering." READ MORE
Kindred pays feds largest penalty ever recorded for integrity agreement violations
On September 20, 2016, Modern Healthcare reported, "Kindred Healthcare will pay a $3 million penalty and close several sites after failing to implement corrections to its billing system under a corporate integrity agreement with the federal government. It's the largest such penalty issued to date.
"HHS' Office of Inspector General said Tuesday that the massive post-acute care provider failed to correct improper billing practices during the fourth year of its five-year corporate integrity agreement, stemming from a prior $25 million False Claims Act settlement with Gentiva Healthcare. Kindred acquired Gentiva in February 2015 in a $1.8 billion deal."
According to the report, "Kindred had other False Claims Act troubles this year when, in January, a subsidiary paid a $125 million settlement over allegations that it knowingly caused contracted facilities to inappropriately bill Medicare. RehabCare allegedly set unrealistic financial goals for its contractors and scheduled patient therapy in order to maximize reimbursements, rather than considering what was best for the patient." READ MORE | OIG
Mylan investigations mount as West Virginia opens fraud probe
On September 20, 2016, Bloomberg reported, "Mylan NV, already under fire from patients over the rising price of its EpiPen allergy shots, is facing a growing number of questions from lawmakers and law enforcement after the state of West Virginia launched a Medicaid fraud investigation into the drugmaker's pricing Tuesday.
"The inquiry, led by State Attorney General Patrick Morrisey, seeks to force Mylan to turn over company documents related to EpiPen. Similar requests have been made in the last month by lawmakers in Washington, and on Wednesday Mylan Chief Executive Officer Heather Bresch is to testify at a congressional hearing about the product's price. The state attorneys general in Minnesota and New York also have inquiries, as do several congressional committees." READ MORE
Skilled-nursing facility operator, execs pay $30M over improper Medicare, Tricare billing
On September 19, 2016, Modern Healthcare reported, "A skilled-nursing facility company and two of its executives will pay $30 million to settle allegations that they charged the government for medically unnecessary rehabilitation therapy services.
"The U.S. Justice Department alleged that North American Health Care sought payment from Medicare and Tricare for medically unnecessary services provided at its 35 skilled-nursing facilities from 2005 to 2011, a violation of the False Claims Act.
"Under the terms of the settlement, NAHC will pay $28.5 million, while board Chairman John Sorenson shells out $1 million and Senior Vice President of Reimbursement Analysis Margaret Gelvezon pays $500,000." READ MORE | DOJ
Former owner of Lake Whitney Medical resentenced
On September 19, 2016, The Hillsboro Reporter reported, "The former owner of Lake Whitney Medical Center was resentenced to federal prison for health-care fraud and identity-theft violations in the Eastern District of Texas recently, according to U.S. Attorney John M. Bales.
"Tariq Mahmood, the 65-year-old Cedar Hill physician, was found guilty by a jury of conspiracy to commit health-care fraud, seven counts of health-care fraud and seven counts of aggravated identity theft following a four-day trial before U.S. District Judge Michael Schneider." READ MORE | DOJ
Audit says home health care companies overbilled Mass. Medicaid by $23m
On September 18, 2016, The Boston Globe reported, "The state's Medicaid program was routinely billed for home health care services that were never provided or were not medically necessary. Providers submitted documents with missing dates and signatures. Sometimes basic information like a patient's medical history was nowhere to be found.
"These and other alleged violations were uncovered in an audit of nine agencies that do business with the state's Medicaid program, called MassHealth — part of an effort by Governor Charlie Baker's administration to rein in soaring spending on home health services." READ MORE
OSHA issues new guidance on settlement approval in whistleblower cases
On September 15, 2016, the Occupational Safety and Health Administration (OSHA) announced in a press release, it had "published new guidelines for approving settlements between employers and employees in whistleblower cases to ensure that settlements do not contain terms that could be interpreted to restrict future whistleblowing. The guidelines, issued Sept. 9, make clear that OSHA will not approve a whistleblower settlement agreement that contains provisions that may discourage whistleblowing without outright prohibiting it." READ MORE
UConn Health pays over $180k in settlement for overbilling allegations
On September 15, 2016, WTNH reported, "Deirdre M. Daly, United States Attorney for the District of Connecticut announced today that in a civil settlement agreement with the federal government, UConn Health will pay $184,984 to resolve allegations that it overbilled the Medicare Program.
"The government alleges that the University of Connecticut Health Center (UConn Health) improperly submitted claims to Medicare for certain wound closure procedures. The specific allegations are that UConn Health submitted claims using codes for higher paying wound closure procedures, rather than using codes for the lower paying wound closure procedures that were actually performed." READ MORE | DOJ
back to top
Regulatory News
This week, MediRegs provided CWN Readers with the following: In the Federal Register, CMS Transmittals, and From the OIG.
CMS Update
Upcoming CMS Events
Dates & Times of upcoming National Provider Calls
Registration is now open for the following CMS Calls:
For details and to Register: READ MORE
For CEU information, visit the Continuing Education Credit Notification web page.
IRF and LTCH QRP Provider Preview Reports – Review your data by September 30
Inpatient Rehabilitation Facility (IRF) and Long-term Care Hospital (LTCH) Quality Reporting Program (QRP) Provider Preview Reports are available until September 30, 2016. Review your performance data on each quality measure prior to public display on the IRF Compare or LTCH Compare websites. For more information:
Corrections to the underlying data will not be permitted during this time. However, you can request a CMS review during the 30-day preview period if you believe the data is inaccurate.
Provider Compliance
Reporting changes in ownership
A 2016 Office of the Inspector General (OIG) report noted that providers may not be informing CMS of ownership changes. Providers must update their enrollment information to reflect changes in ownership within 30 days. Owners are individuals or corporations with a 5 percent or more ownership or controlling interest. Failure to comply could result in revocation of your Medicare billing privileges. Resources:
In the Federal Register
Rule: Medicare and Medicaid Programs; Emergency Preparedness Requirements for Medicare and Medicaid Participating.. 63859-64044 [2016-21404] READ MORE
Rule: Procedures for the Handling of Retaliation Complaints Under the Employee Protection Provision of the.. 63396-63414 [2016-21758] READ MORE
CMS Transmittals
2016 Transmittals READ MORE
Program Integrity (PUB. 100-08)
Transmittal #676 Date: September 16, 2016 - Clarification of Certain Policies in Pub. 100-08, Chapter 15 Regarding the Processing of Form CMS-855R Applications (PDF) READ MORE
From the OIG
Audit Reports
Acronym Library
Medication Therapy Management Program
Medical Transcription Service Organization
To View the full content on this page you might have to login to your HCCA account. If you do not already have a login and password you can create one for free.
If you have a login click here
To create a free login click here
The Health Care Compliance Association (HCCA), is a 501(c)6 non-profit, member-based professional association. HCCA was established in 1996 and is headquartered in Minneapolis, MN. We provide training, certification, and other resources to over 10,000 members. Our members include compliance officers and staff from a wide range of organizations, including hospitals, research facilities, clinics and technology service providers.
Become a member
Renew Membership
Become Certified
Renew Certification
Press Releases
Regional Events
National Events
Web Conferences
Training Products
Past Web Conference CDs
Job Board
Post a Job
Post an Internship
6500 Barrie Rd Ste 250
Minneapolis, MN 55435
Phone - (952) 405-7900 or (952) 988-0141
Fax - (952) 988-0146


text:
Arnolds Fury
Arnold Schwarzenegger reminisces about the good old days in Hollywood, when he used to blow things up and tell people to GET DOWN! Try to clear the wave of enemies in 4 block buster movies; Commando, Predator, Total Recall and Terminator. See how long you can survive in the Arnolds Fury flash shooter.


text:
AboutI am moving from Los Angeles to San Francisco in a few months and I realized there are so many things I have yet to do in Los Angeles. For the next few months, I will do something new every day and post about it. I plan to things I have been meaning to do like Bob Baker's Marionette Theatre or do things I have always loved one last time like our favorite date night of watching PWG Wrestling and then country line dancing at Cowboy Palace. I hope you enjoy and thanks for reading!
Day by Day
January 2019 M T W T F S S « Aug 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31
Recent Comments
charlesianchun on Day #31 Watching PWG Wrestling… charlesianchun on Day #27 Catalina Island 199/365: National Ca… on Day #14 Caviar Tasting 101 at… charlesianchun on Day #24 Meltdown Comics Scott F. Butler on Day #12 Food Truck Row on Wils…
Tag Archives: lake hollywood
Day #30 Hike up to Hollywood Sign
There are many ways to hike around the Hollywood sign and Lake Hollywood, but you have to be with a local or do some research online to know where to go. Most of the access points to the trails … Continue reading
Posted in Kid Friendly, Outdoors Tagged Hiking, Hollywood Reservoir, Hollywood Sign, lake hollywood, Trail Leave a comment
Day #4 Lake Hollywood Dog Park
I had no idea this dog park existed until today. I had brunch with some girlfriends and I mentioned this blog and my friend Stephanie invited Scott and I (and our dogs Max and Penny) to join her and her … Continue reading
Posted in Outdoors Tagged dog park, Hollywood, lake hollywood Leave a comment


text:
Vizcaya Quinceanera Tulle Skirt Gown 89145ID# 15789145
with learn more
Dress to impress in this superb Vizcaya ball gown 89145. Featuring a fully beaded body encrusted with luxurious rhinestones and crystals with an exquisite high halter neckline. Showcasing a detailed open back cut out with a corset lace up back closure that will help cinch in your waist and a full straight tulle skirt adorned with beautiful applique. This gown comes with a matching Bolero Jacket. Shop for more styles like this at Peaches Boutique in Chicago.
- Back Style Corset Lace Up
- Length Long, 60" Hollow to Hem
- Material Applique, Beaded, Tulle
- Neckline Halter, High
- Style Ball Gowns
This is a final sale item. No returns/exchanges.


text:
Upper: Black Boulder WATERPROOF, FLAME, and Cut Resisting Leather With Scuff-Resisting Vibram® Rubber Toe Bumper
Construction: Goodyear Storm Welt
Lining: Comfort Weave / Sympatex® WATERPROOF Barrier, Blood Borne Pathogen Compliant
Insole: Polyurethane Removable Footbed on Flexible Double Rubber
Midsole: Rubber
Shank: Steel Triple Ladder Shank
Outsole: Exclusive Vibram® FIRE Sole with chiseled edge lugs
Special Features: I-Met Metatarsal Protection. L-Protection® Puncture-Resisting Insole Material. This utility and rescue and recovery protective ensemble footwear element meets the requirements of NFPA 1951, Standard on Protective Ensembles for Technical Rescue Incidents, 2007 Edition. This wildland fire fighting protective footwear meets the requirements of NFPA 1977, Standard on Protective Clothing and Equipment for Wildland Fire Fighting, 2005 Edition. ASTM F 2413-05 M/I/75/C/75 Steel Toe. Electrical Hazard. Tested For and Meets CAN/CSA-Z195 Electrical Shock Resistance Standard. Made in USA by ISO 9001 Certified Shoe Company.
Thorogood 10" Structural/T.R.I./ Wildland Fire Fighting Boo
- Brand: Thorogood
- Product Code: 804-6391M
- Availability: In Stock
- Ex Tax: $329.99


text:
Proverbs 25:15 "Through patience a ruler can be persuaded …"
Hollywood is fascinated with the mystique of men, who have initiated change – real change – culturally, religiously, politically, etc. Movies, documentaries, and specials that deal with Abraham Lincoln, Gandhi, and Martin Luther King, Jr. (to name just a few) flourish and spawn additional sequels and spin-offs. Each of those men (and other men and women, who could be mentioned in the same breath) had an obvious and pervasive influence on their world.
But before there was a Lincoln, Gandhi, or King, there was the One they claimed was the inspiration for their missions in life – Jesus. And His influence went beyond just a cultural, religious, or political transformation. He changed – really changed – the world for all time – even in view of eternity.
How did He do it? I know that there were miracles that amazed people and ignited a faith that can move mountains. There was also teaching – truths that can set you free – promises that can transform your life – spoken with authority and confirmed by signs from God.
But there was a man, "approved by God"[i], demonstrating those wonders – speaking as the Son of God; and He was "gentle" and "patient". Though He lived in the public eye for little over 3 years, He changed people's lives. Even though He never won an election or formed a political party or fought in a bloody war, He changed His world. Even though (and because of) He was executed like a criminal and laid to rest in a borrowed grave, He defeated His enemies, formed an army of brothers, and broke through the gates of hell to open a "strait and narrow" way to eternal life and glory.
It makes sense … doesn't it … that Jesus must have listened to His Father's advice – that "patience" can change a ruler and being "gentle" can break a bone?
He tried it. It worked.
So … today … as I read through Proverbs 25; seeking the wisdom of God for my life … I want to give it a try … with my wife and children … with my brothers and sisters … with my boss and co-workers … with my friends and neighbors … with anyone for whom I would like to change their destiny.
Wise saying #25 – "BREAK A BONE."
P.S. Day Twenty-Five … read Proverbs 25. Want some homework?
- Identify the "ruler" you want to change … the "bone" you want to break. Be specific: Your mate? Your child? Your boss? Your roommate? Your parents? What changes do you want to see?
- Once you have identified the person of concern and the changes you anticipate, pray for them – the person and the changes – then get started being "patient" and "gentle" with them. (i.e. No more nagging or sarcasm or rolling eyes or mean looks or snide comments – just "patient" and "gentle" like Jesus … all day … every day until something changes – even if it is you.)
[i] Acts 2


text:
Collation is the assembly of written information into a standard order. Many systems of collation are based on number or alphabetical order, or extensions and combinations thereof. Collation is a fundamental element of most office filing systems, , and .
Collation differs from classification in that classification is concerned with arranging information into logical categories, while collation is concerned with the ordering of items of information, usually based on the form of their . Formally speaking, a collation method typically defines a total order on a set of possible identifiers, called , which consequently produces a total preorder on the set of items of information (items with the same identifier are not placed in any defined order).
A collation algorithm such as the Unicode collation algorithm defines an order through the process of comparing two given and deciding which should come before the other. When an order has been defined in this way, a sorting algorithm can be used to put a list of any number of items into that order.
The main advantage of collation is that it makes it fast and easy for a user to find an element in the list, or to confirm that it is absent from the list. In automatic systems this can be done using a binary search algorithm or interpolation search; manual searching may be performed using a roughly similar procedure, though this will often be done unconsciously. Other advantages are that one can easily find the first or last elements on the list (most likely to be useful in the case of numerically sorted data), or elements in a given range (useful again in the case of numerical data, and also with alphabetically ordered data when one may be sure of only the first few letters of the sought item or items).
A similar approach may be taken with strings representing calendar date or other items that can be ordered chronologically or in some other natural fashion.
To decide which of two strings comes first in alphabetical order, initially their first letters are compared. The string whose first letter appears earlier in the alphabet comes first in alphabetical order. If the first letters are the same, then the second letters are compared, and so on, until the order is decided. (If one string runs out of letters to compare, then it is deemed to come first; for example, "cart" comes before "carthorse".) The result of arranging a set of strings in alphabetical order is that words with the same first letter are grouped together, and within such a group words with the same first two letters are grouped together, and so on.
are typically treated as equivalent to their corresponding lowercase letters. (For alternative treatments in computerized systems, see Automated collation, below.)
Certain limitations, complications, and special conventions may apply when alphabetical order is used:
In several languages the rules have changed over time, and so older dictionaries may use a different order than modern ones. Furthermore, collation may depend on use. For example, German Dictionary and telephone directories use different approaches.
The radical-and-stroke system is cumbersome compared to an alphabetical system in which there are a few characters, all unambiguous. The choice of which components of a logograph comprise separate radicals and which radical is primary is not clear-cut. As a result, logographic languages often supplement radical-and-stroke ordering with alphabetic sorting of a phonetic conversion of the logographs. For example, the kanji word Tokyo (東京) can be sorted as if it were spelled out in the Japanese characters of the hiragana syllabary as "to-u-ki-yo-u" (とうきょう), using the conventional sorting order for these characters.
In addition, in Greater China, surname stroke ordering is a convention in some official documents where people's names are listed without hierarchy.
The radical-and-stroke system, or some similar pattern-matching and stroke-counting method, was traditionally the only practical method for constructing dictionaries that someone could use to look up a logograph whose pronunciation was unknown. With the advent of computers, dictionary programs are now available that allow one to handwrite a character using a mouse or stylus.
The simplest kind of automated collation is based on the numerical codes of the symbols in a character set, such as ASCII coding (or any of its such as Unicode), with the symbols being ordered in increasing numerical order of their codes, and this ordering being extended to strings in accordance with the basic principles of alphabetical ordering (mathematically speaking, lexicographical ordering). So a computer program might treat the characters a, b, C, d, and $ as being ordered $, C, a, b, d (the corresponding ASCII codes are $ = 36, a = 97, b = 98, C = 67, and d = 100). Therefore, strings beginning with C, M, or Z would be sorted before strings with lower-case a, b, etc. This is sometimes called ASCIIbetical order. This deviates from the standard alphabetical order, particularly due to the ordering of capital letters before all lower-case ones (and possibly the treatment of spaces and other non-letter characters). It is therefore often applied with certain alterations, the most obvious being case conversion (often to uppercase, for historical reasonsHistorically, computers only handled text in uppercase (this dates back to telegraph conventions).) before comparison of ASCII values.
In many collation algorithms, the comparison is based not on the numerical codes of the characters, but with reference to the collating sequence – a sequence in which the characters are assumed to come for the purpose of collation – as well as other ordering rules appropriate to the given application. This can serve to apply the correct conventions used for alphabetical ordering in the language in question, dealing properly with differently cased letters, , digraphs, particular abbreviations, and so on, as mentioned above under Alphabetical order, and in detail in the Alphabetical order article. Such algorithms are potentially quite complex, possibly requiring several passes through the text.
Problems are nonetheless still common when the algorithm has to encompass more than one language. For example, in German dictionaries the word ökonomisch comes between offenbar and olfaktorisch, while Turkish dictionaries treat o and ö as different letters, placing oyun before öbür.
A standard algorithm for collating any collection of strings composed of any standard Unicode symbols is the Unicode Collation Algorithm. This can be adapted to use the appropriate collation sequence for a given language by tailoring its default collation table. Several such tailorings are collected in Common Locale Data Repository.
Sorting decimals properly is a bit more difficult, because different locales use different symbols for a decimal point, and sometimes the same character used as a Decimal mark is also used as a separator, for example "Section 3.2.5". There is no universal answer for how to sort such strings; any rules are application dependent.
Ascending order of numbers differs from alphabetical order, e.g. 11 comes alphabetically before 2. This can be fixed with : 02 comes alphabetically before 11. See e.g. ISO 8601.
Also −13 comes alphabetically after −12 although it is less. With negative numbers, to make ascending order correspond with alphabetical sorting, more drastic measures are needed such as adding a constant to all numbers to make them all positive.
When letters of an alphabet are used for this purpose of enumeration, there are certain language-specific conventions as to which letters are used. For example, the Russian alphabet letters Ъ and Ь (which in writing are only used for modifying the preceding consonant), and usually also Ы, Й, and Ё, are usually omitted. Also in many languages that use extended Latin script, the are often not used in enumeration.


text:
Paul Harris Presents Haunted 2.0
"Screams, Gasps, Astonishment"
The World's Greatest Haunted Deck is back on the market!
Peter Eggink started it all with his bestselling Haunted. Mark Traversoni then experimented for literally hundreds of hours with the concept to dramatically alter Haunted's genetic code!
Here's what you can do minutes after opening the 2.0 box:
You place the spectator's signed card squarely into the deck, which is set on the table. You can WALK AWAY from the deck and even cover the deck with a clear bowl (Just like in Peter's original Haunted..there's nothing connecting you to the deck).
After a few moments of silence... the upper half of the deck eerily starts to MOVE... then slowly SLIDES away from the lower half! After the top half of the deck stops moving, there's a pause... then the CARD UNDER IT STARTS TO MOVE! This single haunted card slowly slithers and CREEPS away from the rest of the deck... then finally stops. Your spectator takes the card... it's the one she signed.
Special tips are provided for how to speed up or slow down the deck animation and the creeping card. Easy no-moves steal of the gimmick lets you finish with a normal deck. No palming or switches. Very easy to do. Gimmick is completely self-contained. Nothing attached to performer or table.
Complete with Hand-made Haunted Gimmick and supplies for hundreds of performances, plus the download of Mark Traversoni's Evolved 2.0 handling.
"As of date, Haunted 2.0 is the BEST hands-off effect that surpasses all the previous versions released thus far. IMHO, I don't think one can further improve (of course, in MAGIC there is no effect that can't be improved upon) the working of the effect. As of date, Haunted 2.0 is THE perfect hands-off commercial effect. I would highly recommend to those who are still thinking or are on the fence of purchasing the effect, to please do so now and I am sure that you will be happy that you made the right decision." - Ustaad
"I love everything about Haunted 2.0 Extreme Edition. It works exactly as described which is rare. Easy to perform, consistent, reliable, creepy effect. It is the only Haunted Deck I use now. The ability to do other tricks with the deck before and after gives it a powerful advantage. Love it! Also... Contains everything you need to create your own with your favorite deck." - ZoOpDog
"I still amaze myself how the gimmick can do what it does. This is truly something I do at every booking I perform at, in fact it's now the only card effect in my main set! The effect really does hit people hard. Putting a deck down, having it move like it does, and then to have the chosen card come out gets screams, gasps and looks of astonishment!" - Mark Traversoni
I have been using Haunted 2.0 for over a year now, for special guests, in table hopping situations. I have used a number of methods for the haunted pack effect over the last 40 yrs, and this is by far the eeriest, most convincing method for me. I very highly recommend it.
I really enjoy performing this trick. It's easy to use and get's great reactions. The instructional video was easy to understand and follow. You can truly use any deck of cards.
We ship to you directly from within the UK. While most other UK magic shops hide what happens behind the scenes, we want you to know exactly how things work. Here's the timeline:
Typically takes 2 - 3 days
We send UK orders in batch to the UK from our USA warehouse every day. This way you avoid expensive international shipping fees and taxes.
We keep our most popular products in stock in the UK so often this step is skipped.
We send packages out via MyHermes the same day that we receive them. This is a popular, secure, trackable courier service.
Typically takes 2 days
As soon as the package is dispatched you'll receive a link to track it on this page. While they don't offer any guarantees, MyHermes tend to deliver your order within two days.
At Vanishing Inc. Magic shop we're proud to produce great magic books, tricks, downloads and DVDs.
Every item is carefully selected under the watchful eye of cofounders, and professional magicians Joshua Jay and Andi Gladwin. We don't stock every magic trick released, but instead hand pick the best!
We accept:
Prices in USD. Switch to UK site
© Copyright Vanishing Inc. Magic. shop 2019. Privacy policy


text:
Chinese students do not have rights to protest government policies. However, they have every right to protest a bad cafeteria. As a compromise and interests exchange, Chinese students are usually permitted to show their anger on 'minor' issues, such as bad food in their school cafeterias.
Oct 27, A senior high school in Sanya of Hainan province launched a strike to protest food price at the school cafeteria.
Oct 24, students at Dongfang (Oriental) College in Hebei Province destroyed the school cafeteria.
Sept 13, students at No. 2 senior high school in Shangqiu of Henan Province destroyed the school cafeteria.
The outcome of these kind of conflict usually favors the students, which in a way encourages the frequent protests. The undertone is that except politics, everything is negotiable. Students were told that the reason for bad food were greedy catering companies, and that the Party would take care of their needs.
Oct 25, doctors and nurses in a hospital in Wenling of Zhejiang Province armed themselves with surgery masks protect from tear gas attack while they were holding a funeral service for a doctor who was killed at work by a patient. Medical personnels, like catering staff, are strategically deployed as the vent for people's resentment, and have been treated as such. Doctors and nurses were painted as the reason for high healthcare costs, the public enemy.


text: S Satangel New Member Dec 19, 2017 #1 Posts 2 Dec 19, 2017 #1 How do I remove the Onedrive shortcut in my Windows Explorer left hand menu? I've tried Googling and found a lot of regedit keys but it didn't work out. Anyone else with an idea? Thanks! My Computer System One OS 8.1 64 bit


text:
Yacht Haven Family Practice is committed to providing a superior option for those requiring excellence in medical care. Our services include general practice, pediatric care, evaluation and management of chronic illness minor surgical procedures and more. We know your time is valuable, so we try to see patients by appointment. We also know that life can be unpredictable, so we gladly accept walk-ins and urgent care patients on a priority basis.
Hours of Operation:
Mon-Fri 8:00am – 4:00pm
Contact Information:
Email: email@example.com
Phone: +1 340.776.1511
Website: redhookfamilypractice.com


text: No, not you. Although I have done almost nothing to attract attention to this blog yet (I haven't even told my mother), I do like to check sitemeter to see if anyone has stumbled in here. But I can't get sitemeter to ignore me, so all but about 2 visits are me. I did manage to get my home ip address ignored, but then I promptly left town for a week. I suppose if I accepted all cookies the ignore-this-browser function would work. Come to think of it, maybe the persona I'm allowing to develop on this blog should adopt that as a philosophy of life: I accept all cookies!


text:
In this episode, Mark Sisson has a discussion with Dr. Timothy Noakes of South Africa, who is an author and well-known expert in exercise physiology and human performance. As a physician, former longtime marathon runner, and co-founder of the Sports Science Institute of South Africa, Dr. Noakes has spearheaded efforts to advocate a low carb/high fat diet despite opposition in the mainstream medical community.
Host Brad Kearns talks to legendary old school pro triathlete Andrew MacNaughton. Andrew, a Canadian, was based in Los Angeles during his career on the circuit from 1986-1993. He and Kearns were training partners who both burst onto the scene in the late 1980s to compete at the highest level from seemingly nowhere. Andrew kicked off his 1987 season with seven consecutive victories, including taking down reigning Triathlete of the Year, Mike Pigg.
Known for his cycling prowess, many historians designate Andrew as arguably the finest pure climber the sport of triathlon has ever seen. Andrew amassed leads of over 10 minutes off the bike at Wildflower on a couple of occasions, led the brutally hilly 75-mile Nice World Championships bike ride by 7 minutes in T2, and torched many other bike courses—especially hilly ones—all over the globe.
After his career, Andrew became a sought-after coach with a unique, eminently sensible, and highly practical approach to the sport. Never one to mince words, Andrew is an extremely interesting interview with numerous memorable insights offered up in this show. He has agreed to be a regular guest on the Primal Endurance podcast.
In this episode, Andrew and Brad reminisce about the old days and the many changes, including the high tech influences, that have come to the sport over the years. They also talk a bit about Tim Noakes' Central Governor Theory—how the brain is actually the ultimate limiter of performance rather than the muscles. Enjoy the show!
Mark discusses the role of doping in professional and Olympic sport. Far from a black and white issue, Mark explains that inconsistencies in the testing procedures and random demarcation lines for what constitutes a performance enhancing substance (e.g., Gatorade enhances performance when you are thirsty!). Also discussed is how the public perception that certain athletes cheat to gain an advantage is actually a more complex cultural issue than a true morality weakness. For example, in pro cycling, recent controversies have affirmed that an athlete was virtually compelled to boost blood with doping products to have a chance at being competitive. Furthermore, the highly selective and competitive nature of elite sports compels athletes to search for every possible recovery advantage, including those that cross the line into doping offenses.
Mark explains that we might view modern pro sports as theater, where athletes are performing for the pleasure of fans, with big money on the line, and hence we will always be fighting a battle - perhaps a losing battle - against dopers who might remain a step ahead of the testing efforts. And how there is a bit of hypocrisy with society at large, where use of "performance enhancing" substances (such as caffeine or prescription drugs to treat ADHD for example) is viewed differently than an athlete trying to recover faster.
Host Brad Kearns talks with Brock Armstrong (the voice of the MDA blog podcasts and a Sweetbeat ambassador/product tester) and Ronda Collier, CEO of Sweetwater Health, makers of the Sweetbeat Life iOS application. Sweetbeat Life allows for convenient Heart Rate Variability (HRV) measuring and information storage. This discussion will acquaint listeners with the basics of HRV, and proceed quickly to discuss some of the finer points of HRV's effectiveness in monitoring stress and recovery. Heart Rate Variability is a measurement of the variation in intervals between heartbeats. More variation indicates better cardiovascular fitness and stress management, and is represented in a higher HRV number on a 1-100 scale.
Finer details of this show's discussion include: how Low Frequency (LF) and High Frequency (HF) values correlate with sympathetic and parasympathetic nervous system activity; techniques for how to moderate your stress response and improve your recovery through breathing exercises, yoga, meditation, and extra sleep; and a step-by-step process for how to get started in HRV monitoring (buying the proper equipment, operating the Sweetbeat Life app smoothly, and understanding how to best use the informational graphs generated by the app). This is a fantastic show to help you jump head first into the amazing health technology of Heart Rate Variability!
Listen in as Brad Kearns and Dr. Phil Maffetone have a casual chat about an assortment of interesting topics related to endurance training and general health. Brad complains about his crash and burn patterns, where he feels great for a while and then has down periods of diminished energy and training output. Dr. Maffetone speculates that the cause could be an inappropriate maximum aerobic heart rate value, and urges a conservative approach when calculating your number. He also mentions low vitamin D as a common cause of fluctuating energy levels, and that athletes should strive to get up around 60 or 70 ng/mL. This is way above the mainstream recommendations and a very interesting insight for many sun-starved athletes to consider.
Regarding sleep, Dr. Maffetone urges everyone to get at least 7-9 hours of uninterrupted sleep each night. If you find yourself awakening in the middle of the night, it's a sign of elevated cortisol levels and an overly stressful lifestyle. With high quality sleep each night, napping should be minimally necessary, but a nap of 30 minutes and no longer than an hour can be restorative.
Dr. Maffetone's book, 1:59, discusses the possibility of a human running a sub-2-hour marathon and how it will happen. Maffetone suggests that a smart athlete backing off of the ultra-high volume of today's elites (and running barefoot!) might gain some performance benefits. Maffetone also discusses the difference between the desirable overreaching in training to improve fitness, versus the undesirable state of overtraining (fatigue, depression, hormone imbalance). Brad and Phil discuss the interesting and confusing phenomenon that occurs in the first stage of overtraining. Here, sympathetic (fight or flight) activity is elevated, the athlete feels energized and aggressive, and PRs can even happen. Without a reasonable and intuitive approach, the athlete is headed for a crash when stress hormone production becomes exhausted. Enjoy this informative discussion with Dr. Phil Maffetone, including his own music framing the show! Learn more at PhilMaffetone.com.
Show notes:
Selected Links from this Episode:
1:59 Marathon
The Healthy Golfer
Phil Maffetone
Host Brad Kearns talks to one of the true legends of endurance athletics, Dr. Phil Maffetone. Dr. Maffetone has advised some of the greatest endurance athletes in history, like triathlon champions Mike Pigg and Mark Allen. For decades, Dr. Maffetone has been promoting the benefits of aerobic development and how to protect and nourish health in pursuit of ambitious endurance goals. In this episode, Dr. Maffetone details how to get started with the Maffetone method of endurance training, something that will be of particular interest to any endurance athlete who has experienced fatigue, injury, recurring minor illness, regression or stagnation in performance and especially inability to reduce excess body fat.
Dr. Maffetone says to first start with a self-assessment of your body, performance, and stress levels. Take into account all stress factors, such as consuming refined carbs, drinking too much caffeine, not getting enough sleep, doing too much training and maintaining an elevated heart rate. The second step is identify your maximum aerobic heart rate (the 180 minus age formula detailed in his book, The Big Book of Endurance Training and Racing) and commence a strict base building period. Third is to eliminate sugar and other refined carbs from your diet. Fourth, conduct a Maximum Aerobic Function test once a month to ensure that you are making steady progress in your aerobic development. Enjoy this informative discussion with Dr. Phil Maffetone, including his own music framing the show! Learn more at PhilMaffetone.com.
Show Notes:
Selected Links from the Episode:
Mark Allen
The Big Book of Endurance Training and Racing
Host Brad Kearns talks to ultra runner Timothy Olson of Boulder, CO—the "Conscious Mountain Ultra Runner." Timothy, a two-time champion of the prestigious Western States 100-mile Endurance Run, is known for his evolved, mindful approach to ultra distance running and also for being one of the most prominent adopters of primal-style eating habits among elite endurance athletes.
This show details how Timothy's dietary choices help him optimize fat metabolism during long workouts, improve his recovery time and improve his overall enjoyment of life. He credits avoiding his former All-American grain-based diet for eliminating his former long-term recurrent stomach distress. Amazingly, he reports that his wife Krista has been able to put her decades-long condition of Juvenile Rheumatoid Arthritis (JRA) into remission by following a primal eating strategy.
Timothy also discusses his unique motivations for competing at the highest level and pushing his body to the edge of human endurance—things like his appreciation for nature, the connection he feels with other ultra runners, and how running strengthens his ability to be more mindful and appreciative of all elements of daily life. This guy is onto something special with his mindset, his healthy whole foods diet, and his awesome athletic feats. Enjoy his commentary and follow him on social media by visiting TimothyAllenOlson.com
Show notes:
Selected Links from the Episode:
Enjoy the inaugural Primal Endurance Podcast with Brad Kearns and Mark Sisson. Brad and Mark discuss an assortment of topics relating to a Primal approach to endurance training, offering somewhat of a sneak preview of the topics covered in their long-awaited book, Primal Endurance.
This show really sets the tone for the provocative and sometimes controversial topics covered on the Primal Endurance Podcast. Be sure to subscribe, shows are published on a weekly basis!


text:
All pictures and information are from Bergdorfgoodman.com
Bottega Veneta - Woven Flap Bag - Bergdorf Goodman
Women Flap Bag in White
• White woven leather.
• Gold-tone hardware.
• Buckled shoulder strap; front flap.
• 8 4/5"H x 11 1/5"W x 4 3/5"D.
• Made in Italy.
Bottega Veneta - Chain Hobo, Mahogany - Bergdorf Goodman
Chain Hobo in Mahogany
Chain reaction: signature woven leather with contemporary metal accents.
• Mahogany woven leather.
• Gold-tone hardware.
• Inset chain detail on front.
• Shoulder strap; zip top.
• 20"H x 20 2/5"W x 1 1/5"D.
• Made in Italy.
Bottega Veneta - Pleated Bag - Bergdorf Goodman
Pleated Bag in Mahogany
• Brown pleated leather.
• Gold-tone hardware.
• Buckled shoulder straps; framed top.
• 8"H x 14"W x 6 2/5"D.
• Made in Italy.
Bottega Veneta - Chain Bag - Bergdorf Goodman
Chain Bag in Brown
Chain gang: signature woven leather with fresh hardware.
• Brown woven leather.
• Gold-tone hardware.
• Inset chain detail on front.
• Buckled shoulder straps; framed top.
• 8"H x 15"W x 7 2/5"D.
• Made in Italy.
Bottega Veneta - Embroidered Nappa Handbag - Bergdorf Goodman
Embroidered Nappa Handbag in Grey
• Gray nappa leather.
• Brown embroidered front.
• Gold-tone hardware.
• Woven shoulder straps with tabbed ends.
• 11 1/5"H x 12 2/5"W x 4 4/5"D.
• Made in Italy.
I love the Chain Hobo.
I've been lusting after it since I saw it on the BV website.
I also love the Continental Wallet in the same design.
I love the Pleated Bag!!!
I love the woven flap bag in white. They have it at the Nordstroms near me and I try it on every time I come in. It is so soft and delicious and is the perfect size and shape for me. And a great white color.
wow nice bags!
Seriously nice! I'm liking all of them, particularly the chain bag in brown. It actually looks like it might be worth the 3K..
The pleated bag is amazing IRL. I saw it last week in a BV shop. The pleated leather is woven, so there is a lot of it used in making the bag. Not sure how well it will sell, tho. Love the chain hobo, too. The woven flap shoulder bag is a lot like my black one. The white is gorgeous.
I don't care for the last one that's embroidered- it reminds me of a summer camp craft project. I like the chain hobo too but I think it's quite a bit more in price than the hobo without the chain so I think I would get it plain and save $500 or so.
Thanks for posting this bag.lover- I do a search every day for BV just to see if anyone is talking Bottega.
Beautiful. I loveeee the embroidered Napa handbag. So unusual. I religiously look at it on the website in Pink and I drool.
Bagpuss that is so funny. I do exactly the same search everyday. I thought it was just me who did that
I love the pink options in the Resort collection!!
I'm not typically a pink bag gal, but then the pinks are SOOO pretty!
P/s Am guilty of seeking out BV threads as well!


text:
Pippa Middleton's wedding to James Matthews sealed with a kiss
Trump visit seen as long shot to revive Israeli-Palestinian peacemakingChannel 2 TV said one American official told the Israelis the site is "not your territory" but part of the occupied West Bank. The Wall stands in the Old City in the east of Jerusalem, which Israel captured during the 1967 Middle East war.
Price Target Analysis Novavax, Inc. (NVAX)The current share price indicate that stock is -10.75% away from its one year high and is moving 16.85% ahead of its 52-week low. Zacks Investment Research cut Novavax from a "hold" rating to a "sell" rating in a research report on Saturday, January 21st.
Congressman calls for Trump's impeachment on House floorGreen, who previewed his call with a tweet earlier, said it was the House of Representative's "duty" to take up impeachment. The president must be impeached!" Waters has received her fair share of impeachment backlash from Trump supporters.
Steve Mnuchin Walks Back Administration Support of Glass-SteagallThe three have substantial footprints in commercial and investment banking, so their business models would be severely impacted. Mnuchin added, "There'll be a box that you have to check that says, I'm eligible for the business tax, which is 15 percent".
Myles Garrett makes interesting song selection while signing rookie contractWhy should I be afraid of saying those kinds of things? You are trying to go out there and win games just like they are. The Browns open next season against the Steelers, their longtime rival who has overpowered Cleveland in recent years.
Trump reportedly asked Comey to consider imprisoning members of the pressHe dismissed outrage over Trump's disclosures as USA politicians whipping up "anti-Russian sentiment". Gerhardt said Trump's recent comments and behaviour are "disturbing" and "justify a further inquiry".
GST Bill hits hurdles in Odisha AssemblyThe two-day crucial meeting is being held at the Sher-e-Kashmir International Convention Centre (SKICC) in Srinagar . The rates fixed will be charged from July 1, the scheduled date for rolling out GST.
Blizzard REVEALS new Skins and voice linesAll the Overwatch and Blizzard fans are in for a massive treat next week as the developer prepares for the big Anniversary Event. In the lead up to the event, Blizzard has revealed new skins for Soldier 76, Pharah, Bastion and Zarya (via PvP Live ).
Salient features of ICJ's ruling on Kulbhushan Jadhav caseThe judges said India had a "plausible" argument that Pakistan violated global law by refusing to grant consular access to Jadhav. The worldwide court of justice, sometimes referred to as the world court, is the UN's court for hearing disputes between states.
Chinese, S. Korean officials seek to mend rift with meetingsTrump said he expects positive results on the North Korean nuclear issue through close cooperation with the Moon administration. Shares in AmorePacific 090430.KS , its largest cosmetics firm, were up 0.9 percent.
Gap posts surprise same-store sales rise as Old Navy shinesWhile arriving at a price target, analysts and investors alike use various metrics to determine where the stock might be directed. After a recent look, shares have been seen -2.79% from the 200-day moving average, and -3.42% from the 50-day moving average.
Gay Couple Sentenced to 85 Lashes By Sharia CourtThe appeal comes following the news that two gay men will be publicly caned 85 times for having sex out of wedlock. . Aceh is the only province in the world's most populous Muslim-majority country which implements Sharia law.


text:
Once the "mandatory" evacuation order came, our bishop dispensed Catholics in the affected areas from the obligation to attend Mass and we priests in the same area could evacuate as good and obedient Georgian citizens.
Although I could have evacuated, I decided to stay and have the normal Masses at St. Anne, 5:30 PM on Saturday and 8:30 and 11:00 AM on Sunday. Our new $10,000,000 Church can seat up to 1,200. On Saturday, we had about 100 attending and on Sunday about 75 at each morning Mass. (I thought to myself, what if this was the normal attendance each Sunday in a 1,200 seat church--what to do, what to do?) Of course we could sell the church to a booming non-denominational church and moved Sunday Mass back to our original Henry Ford Church, the Martha and Mary Chapel named after his mother and mother-in-law. In fact up until about 12 years ago, that little chapel was more than adequate as the parish only had about 100 families compared to the 1,000 today. But I digress).
I read that some of the Protestant sects held digital services on the internet so that people could worship via the internet wherever they were even if on the road to evacuation. That doesn't work too well for us, but I guess I could celebrate Mass wherever I evacuated to and live-stream it for parishioners. And since the Catholic laity don't need to receive Holy Communion when they attend Mass, only the priest to complete the Sacrifice, wouldn't that work just as well? It's a cool idea, a digital Mass so people can stay at home. But what about the Offertory? The real one, not the offering of the offerings, but the money? How would I get paid? What about my stipends? Oh my!
Since I had about 250 Catholics attending Mass, law breakers who should have evacuated by the time of the Masses, I decided to join my lawbreaking parishioners and not evacuate either. I told them at Mass that I was staying since they were and if anything happened to me it was their fault. As a good Italian, I love placing guilt trips on others!
My rectory is in a normal neighborhood, and believe it or not, eight miles south east of the church (meaning closer to the ocean and tidal marshes and rivers). I've never lived so far from the Church, but I do have a small chapel in the house. I've gotten use to the commune back and forth several times a day. But I digress.
Since Hurricane Irma decided to set her eye on the west coast of Florida and middle and west Georgia, we didn't start to get tropical storm winds until Monday afternoon. What Jacksonville, Brunswick (St. Simons Island), Richmond Hill and Savannah didn't realize is that the tides (which in our area make dramatic shifts from high and low, almost like the Bay of Bundy in Nova Scotia or is it New Brunswick?) would cause some major flooding.
Jacksonville had historic flooding from the St. John's River, which is more lake-like than river-like and like the Nile in Egypt flows northward.
Richmond Hill near my rectory had the Tivoli River (a tidal river with a major surrounding marsh) overflow its banks, cover a bridge and the roadway leading to and from it. I can walk to this bridge which has a great fishing, shrimping and crabbing dock which I did yesterday. The locals said they had never seen anything like it and neither have I! I walked back toward my neighborhood only to see the marsh turning into a major lake and approaching a beautiful home built on the edge of the marsh and soon to be consumed by the rising waters that covered the road in front of it that leads to my subdivision.
The Savannah River in Savannah (which is also a tidal river) overflowed its banks and approached businesses on Riverstreet, a popular tourist destination.
Of course all of this means that global warming, which some say is manmade and other say is an Act of God, is leading us to Armageddon, no?


text:
Customer portal
Budjetti £20000-50000 GBP
We require a front-end portal and back-end database built.
Its purpose will be to connect to some servers which have pre-written APIs and present that data to the front-end portal.
It is a big project and will probably take 6 months to complete in phases.
Looking to find companies capable of delivering this and understanding technologies required.
51 freelanceria on tarjonnut keskimäärin %project_bid_stats_avg_sub_26% %project_currencyDetails_sign_sub_27% tähän työhön
Thanks a lot for the project posting, we are very interested in working on this project. We are well established company and having above 100 employees. We already working with the world class clients with proven exper Lisää
Let's discuss your project and go through the details together. Please message us so we can begin the discussion. We are the #1 US (as in United States, born and raised) provider for custom, high-level sites, bro Lisää
Dear Sir, I have read Project Description & understand that this is a big project and happy to work with you on this kind of big project. We have 40+ developers, few designers and some other staff, we have very orga Lisää
Hello, We are IT-Engineers with higher educations, having more than 15 years of experience, developing sophisticated Web and Mobile solutions from scratch. Our indicative time/cost estimation for your project rel Lisää
Hi Dear, Good Day! After reviewing your requirements, I will gladly help you to complete your project. I have already completed the similar projects before and very much clear in requirements, and ready to get st Lisää
Hi, After reading over your application this looks like a perfect fit for my skill sets, it would be my pleasure to work for you. I see that you are looking for someone to help you in development front-backend, Me Lisää
Hi, Please share more details. Ready to start right away, let's discuss this a bit more please. Please check our profile, we have perfect feedback and statistics :) Some recent projects: [login to view URL] Lisää
Hi There, Thanks for your valuable time. :-) Please check below points : 1. We require a front-end portal and back-end database built. ==> Ok. 2. Its purpose will be to connect to some servers which have p Lisää
Hi, We are a company & having great expertise in technologies required. We have great expertise in frontend with experience of backend database connectivity. We have great experience integrating pre written APIs. Lisää
Hello, Hope you doing well..!! I checked your all requirement that you need to developer & designer that provide you a customer portal with unique design and quality development and time. I would like to say th Lisää
Hello Roland, Greetings from Emizen Tech Pvt. Ltd. We are a well-established company with over 60+ employees with 48 front-end and back-end developers at our disposal. We can deploy a dedicated team for any kind of Lisää
Hello I read your description, and got only what I have to work with. I would like to get the requirement and discuss in detail to work on the project. So feel free to send me message when you're free. Regards, Lisää
Hi, As per your description that you want a Customer Portal with a backend database that will connect to servers having pre-written APIs and fetch the data from them to display on the front end of the website. The p Lisää


text:
It was a beautiful day in Randolph recently as more than 200 people attended the yearly Old Fashioned Sunday celebrations at the Friendship Bible Church. The Gospel from an 1861 sermon by Charles Spurgeon , entitled "God's First Words To The First Sinner", was shared by Pastor Bill Johnson who was also dressed like Spurgeon . Everyone enjoyed roasted pig and chicken prepared by Luke Ward which accompanied the covered dishes carried in by the congregation as in the olden days. Great Gospel music of Bobby Bowen and his family was performed during the morning and afternoon services along with congregational singing and other special groups during the afternoon. Winners of the pie contest included Eleanor Jones in first place with her Toasted Coconut Pecan Carmel Pie, second went to Beth Salisbury for her Chocolate Pudding Pie , and third place went to Cheryl Salisbury for a Deep Dish Apple Cider Pie. Some of the best dressed in old fashion attire included the Salisbury family, Eleanor Jones, Paul Richards and Bob Smith.
Everyone seemed to enjoy the good service, fellowship, food and music in an old fashioned way.
Starting Point > Pictures >


text:
NOTE: The HERALD-MAIL Online publishes the obituaries that run in The Morning Herald edition. To view previous obituaries, please see our archives section.
Wednesday, December 30, 1998 Edition
Dorothy M. Peacock
BERKELEY SPRINGS, W.Va. - Dorothy Mae Peacock, 68, of Berkeley Springs, and formerly of Forestville, Md., died Monday, Dec. 28, 1998, at her home.
Born Oct. 28, 1930, in Washington, D.C., she was the daughter of the late James and Alice Fodder Cox.
A real estate leasing consultant, she recently retired due to illness. She also was a homemaker.
She was of the Baptist faith.
She is survived by two sons, Clifford Carr "Chuck" Peacock of Portsmouth, Va., and Jay Robert Peacock of Berkeley Springs; seven grandchildren; four great-grandchildren; nieces and nephews.


text:
EM for mixtures - Initialization requires special care
EM for mixtures - Initialization requires special care - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.
1 LSTA - Laboratoire de Statistique Théorique et Appliquée 2 SELECT - Model selection in statistical learning Inria Saclay - Ile de France, LMO - Laboratoire de Mathématiques d-Orsay, CNRS - Centre National de la Recherche Scientifique : UMR
Abstract : Maximum likelihood through the EM algorithm is widely used to estimate the parameters in hidden structure models such as Gaussian mixture models. But the EM algorithm has well-documented drawbacks: its solution could be highly dependent from its initial position and it may fail as a result of degeneracies. We stress the practical dangers of theses limitations and how carefully they should be dealt with. Our main conclusion is that no method enables to address them satisfactory in all situations. But improvements are in-troduced by, first, using a penalized loglikelihood of Gaussian mixture models in a Bayesian regularization perspective and, second, choosing the best among several relevant initialisation strategies. In this perspective, we also propose new recursive initialization strategies which prove helpful. They are compared with standard initialization procedures through numerical experiments and their effects on model selection criteria are analyzed.
Keywords : model selection criteria regularized likelihood recursive initialization EM algorithm initialization strategies Gaussian mixture models
Autor: Jean-Patrick Baudry - Gilles Celeux -
Fuente: https://hal.archives-ouvertes.fr/


text:
Post-Industrial legends PIG
announce the release of their new remix album Swine & Punishment and North America tour.
Swine & Punishment … More of each from PIG, the industrial infidel.
With the release of Swine & Punishment we truly hear the sound of the lunatics rampant in the asylum. Raymond Watts has unlocked the door to his innermost (song) parts, and what mayhem these Apostles of Pork have wrung from what were once upstanding (and outstanding) songs from the previous album The Gospel
Swine & Punishment features remixes from such artists as Mortiis, London After Midnight, Tim Skold, Chris Vrenna, Kanga and more. Swine & Punishment is out now on Metropolis Records.
01. Viva Evil (Oumi Kapila Remix)
PIG will also be heading out on a full North America tour in support of their new releases The Gospel and Swine & Punishment. VIP packages are available via PIG'S website. Playing along with Raymond Watts in PIG during the tour will be legendary artists En Esch and Gunther Schultz (KMFDM) and Z.Marr and Joe Letz (Combichrist)
Tour Dates
6/28 Detroit, MI @ Smalls
About PIG
In 1986 Raymond Watts awoke in West Berlin. It was a time of terror and turmoil, in a city so depraved and decadent that the East Germans had walled it in. Watts had cut his teeth on tape loops in London and Hamburg, but inspired by Berlin's fetid air and his first 8-bit sampler, Watts gave birth to PIG in 1988. A year earlier, in Hamburg, he had written and recorded the first KMFDM album and single with En Esch and Sascha Konietzko. He had also helped deliver the sonic slaughter of Einsturzende Neubauten, Psychic TV, Die Haut, and most of the Berlin and Hamburg underground, as both live and studio sound engineer, and producer.
PIG was cut from the belly of Raymond Watts with a rusty screwdriver in a basement opposite The Wall. The first squeals were committed to tape and saw the light of day as A Poke in the Eye. Wax Trax! jumped to release it.
When The Wall collapsed, the party was over. Watts returned to London and PIG albums poured forth: Praise the Lard, A Stroll in the Pork, Shit For Brains, Red Raw & Sore and The Swining. Watts programmed, produced and performed, ploughing a lone furrow until Karl Hyde, singer and sinner with Underworld, came to his assistance on guitars.
Watts also rejoined KMFDM in 1994, for the PIG vs KMFDM EP Sin, Sex & Salvation. On the ensuing album Nihil Watts took over writing and vocal duties, spawning Juke Joint Jezebel, the massive crossover industrial/dance hit. Multiple remixes of Juke Joint Jezebel by Georgio Moroder took the single to a whole new audience. Many sold-out and heaving tours followed, with Watts orchestrating the chaos from centre stage like a rampant ringmaster armed only with talent and tequila.
When not on tour, Watts could be found in his Ranch Apocalypse studios in London, working on PIG's No One Gets Out of Her Alive, Prime Evil, Disrupt Degrade & Devastate and the KMFDM albums Attak, Symbols and WW III. On the album Genuine American Monster, Watts reunited with legendary guitarist Guenter Schulz. While in Toyko, Watts gave birth to the band Schwein with the Japanese superstars Sakurai and Imai. The albums Schweinstein and Son Of Schweinstein and a sold-out tour ensued.
After releasing the PIG album Pigmartyr (Pigmata on Metropolis), Watts spent time in London indoctrinating his piglets and initiating them into the parish of pork. When not leading his children down the path of righteousness, he could be found writing music for the shows and films of Alexander McQueen, Chloe, Marios Schwab, Halston, The Row and others. He also wrote music and did sound design for Punk: Chaos to Couture, the exhibition at the Met in New York.
In the final show before his death, Alexander McQueen commissioned Watts and John Gosling, Watts's old partner-in-crime from Psychic TV days, to embellish the serene instrumental track Inside, from PIG's Genuine American Monster album. This became the fluid soundtrack to what is seen as McQueen's masterpiece, Plato's Atlantis. This show was reprise as the finale of Savage Beauty, the McQueen retrospective that broke all records at the Met in New York and the V&A in London. He also wrote other original music and did sound design for the show.


text:
This page describes the procedure for installing the eBahn Reader application on Windows 7 within XP Mode.
Applies to: eBahn 3, Windows 7, XP Mode
Installing eBahn Reader from a DVD
Windows XP Mode
Make sure that you are in the window: Windows XP Mode - Windows Virtual PC on your Windows 7 PC:
- insert the eBahn Desktop DVD
- if the installer does not auto-run:
- right-click on the Start menu (in the XP window), and select "Explore"
- navigate to your DVD drive
- find and double-click on the icon that reads: Setup (Setup Application)
- follow the on-screen instructions
- install to the recommend folder
- if the program does not "auto-activate", you may need to do an offline activation
- Manually Activating a Vehicle (without an internet connection) https://wiki.bentleypublishers.com/x/G4Ag
Create shortcut for eBahn Reader (XP Mode)
Creating this shortcut will allow you to start eBahn in XP Mode without having to first launch XP - it will appear seamless (as though it's not in it's own window)
- right-click on the Start menu and select Explore
- find the folder C:\Documents and Settings\XPMUser\Start Menu\Programs\eBahn
- select and copy the shortcut file called "eBahn Reader (shortcut)"
- now find the folder C:\Documents and Settings\All Users\Start Menu\Programs
- paste the eBahn Reader shortcut file here
This will allow eBahn Reader to appear in the Start menu when you start your PC. It may take a minute for your PC to detect this change.
Related pages
- XP Mode Step-By-Step Setup Instructions https://wiki.bentleypublishers.com/x/EQBZAg
- Can my PC run Windows XP Mode? https://wiki.bentleypublishers.com/x/FABZAg
- Windows 7, Vista and XP Compatibility https://wiki.bentleypublishers.com/x/DQBZAg
|Install eBahn Reader on Windows 7 in XP Mode https://wiki.bentleypublishers.com/x/GgBZAg


text:
For research purposes I spent the morning at the Cambridge Equine Hospital. Take it from me, you ain't seen nothing until you have seen an anaesthetised horse stretched out in an operating theatre with tubes coming and going everywhere, undergoing arthroscopic surgery on its hock.
Fun fact: the first thing a horse wants to do on waking up after surgery is to eat, and eat right now.


text:
This article is written to introduce a new tool called shARP. It is an anti-ARP-spoofing program and uses active scanning process to identify any ARP-spoofing event.
ARP spoofing allows an attacker to intercept data frames on a network, modify the traffic, or stop all traffic. Often the attack is used as an opening for other attacks, such as denial of service, man in the middle, or session hijacking attacks. Our anti- ARP spoofing program, (shARP) detects the presence of a third party in a private network actively. It has 2 mode: defensive and offensive.
- Defensive mode protects the end user from the spoofer by disconnecting the user's system from the network and alerts the user by an audio message.
- Offensive mode disconnects the user's system from the network and further kicks out the attacker by sending de-authentication packets to his system, unable him to reconnect to the network until the program is manually reset.
The program creates a log file (/usr/shARP/) containing the details of the attack such as, the attackers Mac address, Mac vendor time and date of the attack. We can identify the NIC of the attackers system with the help of the obtained Mac address. If required the attacker can be permanently banned from the network by feeding his Mac address to the block list of the router.
Let's start!
Open the terminal in Kali Linux and type following command to download it
Git clone https://github.com/europa502/shARP.git
If the user wants to secure his network by scanning for any attacker he can run the program. The program offers a simple command line interface which makes it easy for the new users. Now type the following command to run this program:
Chmod 777 shARP.sh
./sharp.sh -h
Then we had used zanti for sniffing in the network and start MIMT attack on selected target IP: 192.168.1.9 so that we can view its network traffic.
When the user runs the program in defensive mode, As soon as the program detects a spoofer in the network, and it disconnects the user's system from the network so as to protect the private data being transferred between the system and the server. It also saves a log file about the attacker for further use.
./sharp.sh –d eth0
From screenshot you can the highlighted text is showing the Mac address of android phone trying to perform spoofing.
So when it finds spoofing in the network, it disconnects the user from the network. From the screenshot you can see now user is assigned with its localhost IP.
Author: AArti Singh is a Researcher and Technical Writer at Hacking Articles an Information Security Consultant Social Media Lover and Gadgets. Contact here


text:
Val & Phil Willy
here it is - "The Kiln"
Lucy (daughter of Val and Phil)
Val, myself and Phil
One thing I do love and will miss very much when I leave the gallery, is my visits to the Artist Studios - over the years I have visited the studios of most of my artists to see "work in progress" and I love it. I finally got the chance to visit Val and Phil Willy, wonderful potters from the Sunshine Coast. What an amazing studio, and I was fascinated to find out the process of the raku clay sculptures they create in this amazing studio. We knew we had the right address when we spotted the sculpture sitting on the letterbox! oh and did I mention what a delicious home made cake we had with a nice cup of tea! I selected some gorgeous little sculptures for the gallery including little houses, little sheep and the new line of magpies...simply beautiful!


text:
Water damage is a terrible thing to go through; however, it helps to know that Plumbers FL Services will be there quickly and efficiently when needed. Christian and Carlos make a great team. They are friendly, polite, and hard working. They are a credit to the Plumbers FL, and I'm glad they were here to help me. Thank you Christian and Carlos and the Plumbers FL crew. I always call Plumbers FL, and recommend their services to neighbors and friends. Thank you.
We have used Plumbers Florida many times in the past. The technicians are always pleasant, professional and do outstanding work. Our last experience was with William who went above and beyond our expectations. His communication skills and advise were spot on. As well as just a really, really nice man!!!
This best luxury waterfront condos for sale Madeira Beach is the best apartment for sale Redington Beach or waterfront luxury condo for sale Treasure Island.
Welcome to luxury, direct Gulf front living at the Sereno Condos on Madeira Beach, with 480 feet of pristine beach frontage. Your fourth floor home is uniquely located in the building providing sensational views of the beach and spectacular sunsets year round. This three bedroom, three and one half bath split plan home has open views of the beach from the Kitchen, Greatroom and Master Bedroom. Bedrooms 2 and 3 share views of the Intercoastal waterway. The Master Suite opens to the 26 ft. Beach Terrace, ha s his & her walk-in closets and a large Bath with twin vanities and sinks, soaker tub and separate shower. Bedrooms 2 and 3 have full, private baths. 10 Foot ceilings throughout the home enhance the luxurious finishes that include crown molding, Granite counter-tops and exquisite attention to other custom details.
This luxury waterfront condo for sale in Madeira Beach is the best apartment for sale near Redington Beach or compared to any waterfront luxury condo for sale Treasure Island right now. It Will sell fast.
The Chef's delight kitchen features a large center island, wine cooler, upgraded appliances, pantry, breakfast bar, lots a storage in the custom cabinets and plenty of counter space. Community a Amenities include: one secure parking space in the garage and one assigned spot in the parking lot, professionally equipped fitness center & community room with wet bar overlooking the pool and beach, lushly landscaped heated pool and spa area, outdoor grilling area, high speed elevators. Conveniently located and minutes away from the many cultural, recreational and business opportunities of the Tampa Bay Area. Call us for a Floor plan and additional photos or to schedule a viewing.
Thank you for viewing this luxury waterfront condo for sale Madeira Beach which is the best apartment for sale Redington Beach or waterfront luxury condo for sale Treasure Island.


text:
There is no shortage of microbiome-focused startups in biotech right now. The link between the gut microbiome — the entire collection of microbes living in the gut — and diseases such as inflammatory bowel disease are well-established. New research has made it clear, however, that the gut microbiome also impacts neurological health, leading to the phrase "the gut-brain axis." Let's explore this connection and examine the early efforts by a few innovative biotechs to translate these new discoveries into the clinic.
The human microbiome is the complex collection of microbes (mostly bacteria, but also includes small numbers of fungi and viruses) that reside on and inside the human body, including our skin, mouth, nose, respiratory tract, and digestive tract (gut). The microbiome is huge — microbial cells outnumber human cells by a ten to one ratio! Human cells are much larger than bacteria cells, however, so don't worry — you're still mostly human. For every 100 pounds that you weigh, it is estimated that about two pounds of that weight come from bacteria.
Most of us think of bacteria as harmful and certainly some types are; however, those that have evolved with humans to become part of the human microbiome are either neutral — causing no harm — or beneficial. Scientists are busy trying to better understand and characterize these beneficial bacteria and the role that they play in human health.
The gut contains the largest number of bacteria, as well as the greatest diversity of bacteria, when compared to other parts of the body. Thus much of the attention directed towards the human microbiome has been focused on the gut microbiome in particular, which continues to surprise us with its influence on diseases such as obesity, diabetes, and, increasingly, brain disorders.
Axial Biotherapeutics (Cambridge, MA) is focusing much of its initial attention on work originally done at microbiologist Sarkis Mazmanian's lab in the California Institute of Technology (Pasadena, CA) — mostly relating to the gut-brain axis' role in Parkinson's disease (PD) and autism.
Parkinson's Disease
Parkinson's disease (PD) is a chronic and progressive movement disorder, according to the Parkinson's Disease Foundation. Symptoms include tremor of the hands, arms, legs, jaw, and face; slowness of movement; rigidity of the limbs and trunk; and impaired balance and coordination. These symptoms are caused by the malfunction and death of neurons that produce the neurotransmitter dopamine. PD affects nearly one million people in the U.S., and the cause is unknown. About 75% of PD cases are accompanied by gastrointestinal disorders such as constipation, which provided an initial impetus to examine a possible connection between gut health and the disease.
A key molecular characteristic of PD is the aggregation of a protein called alpha-synuclein (αSyn) within cells of the brain and gut. Researchers in the Mazmanian lab used a strain of mice that overproduce αSyn to study the disease. One group of the αSyn mice were bred in a completely sterile environment to create "germ-free" (GF) αSyn mice. The other αSyn mice had the normal collection of gut bacteria. On a series of tests designed to assess motor skills, the GF αSyn mice performed significantly better — suggesting that even in mice that overproduced the αSyn protein, the presence of certain microbes are required for the disease to progress. Further work suggested that a molecule called butyrate, produced by certain gut bacteria, can enter the brain and activate an immune response, leading neurons to malfunction or die.
There is reason to believe that this connection is also at work in humans with PD. In collaboration with Rush University (Chicago, IL) gastroenterologists, Mazmanian lab researchers transferred fecal samples from PD patients into the GF αSyn mice. Fecal transplants are an established way to "reset" the gut microbiome of the recipient to make it match that of the donor. After transplantation, the mice began exhibiting symptoms of PD. Transfer of fecal matter from healthy people did not trigger these symptoms. These experiments suggest that the gut microbiome is a major contributor to the disease process in PD patients.
Of course, these promising early stage findings still need to be translated into human therapeutics. This may be easier than traditional neurological approaches because it is much easier to deliver drugs to the gut than to get them to cross the blood-brain barrier. Following up with a targeted approach to modulate the production of butyrate and other inflammatory compounds produced in the gut may bring the first truly effective PD therapy into the clinics.
Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a developmental brain disorder characterized by impaired social interaction, communication, and restrictive and repetitive behavior. These symptoms impact a child's educational, social, emotional, and physical development. More than 3.5 million Americans live with an autism spectrum disorder according to the Autism Society. The cause is unknown, although genetics is thought to play a role.
Similar to PD, a significant portion of ASD patients exhibit gastrointestinal problems. The Mazmanian lab demonstrated that feeding ASD mice a specific strain of bacteria called B. fragilis — a part of the human microbiome — altered the mouse microbiome and reduced some of the ASD-like behaviors such as anxiety and repetitive behavior, and increased levels of communication with other mice. These experiments suggest a possible probiotic therapy for autism.
Another early-stage company making headlines in the gut-brain axis space is Symbiotix (Boston, MA). Focusing on multiple sclerosis (MS), their lead candidate is a carbohydrate molecule produced by B. fragilis. This therapy increases the production of regulatory T-cells, which are a class of T-cells that "turn down" an overactive immune response by releasing anti-inflammatory signaling molecules. Symbiotix is preparing to enter clinical trials with an orally-administered product for the treatment of MS and inflammatory bowel disease.
The emerging work described here gives credence to the old expression "think with your gut." In addition to the diseases discussed above, scientists are discovering links between the gut microbiome and other brain disorders such as anxiety and depression. As the story continues to unfold, we are likely to see new therapeutics based on restoring the balance that millions of years of human-microbe co-evolution has fine-tuned.
Emily Burke, PhD has worked in biopharma for 20 years, gaining science writing experience at The Scripps Research Institute and Ionis Pharmaceuticals. As a Ph.D. molecular biologist, she is passionate about advancing the public's understanding of science. In addition to being a self-proclaimed "science geek," she is regularly asked to speak at international scientific meetings. When not teaching and writing the WEEKLY for Biotech Primer, Dr. Burke swims with her swim club and performs regularly on the improv circuit in San Diego.


text:
Sunday, March 3, 2013
Spring Fashions!
5 comments
Hey Suzanne,ReplyDelete
Well, I typed a huge comment to your blog and I think it disappeared so I'll try again :) Isaac is watching Baby Mozart right now which ususally gives me about 20 minutes of computer time (he LOVES Baby Mozart!). I'm a huge fashion nut, but my budget doesn't let me act out on that nuttiness :) Back when I worked at a huge law firm and had a bit of extra money, I bought myself 2 pairs of Manolos, one pair of Louboutin's, and one pair of Chanel heels (I LOVE shoes, the taller the better). These were sample sales so just a ocuple hundred dollars each, but they are wonderful and I always feel so good in them :) I love bright colors in fashion, but for some weird reason, I'm hesitant to wear them (guess sometimes I don't want to stand out). I wear suits to work because I'm in court all the time, so I generally go to work in gray or black suits. The only fun I have with my wardrobe at work is my shoes (and jewelry, most of which I get on Etsy, I have a homemade, funky style of jewelry most of the time) :) My favorite stores are White House Black Market, Gap, Express, and Macy's. Now ask me what I can afford :) These days I shop at Kohl's and Penney's, just because it fits in the budget (hey, if I'm going to get my condo in Charletson, SC, I have to cut back somewhere right :) ). I do need some new nice pieces though. Before getting pregnant, I had put on a little weight. Now, I've lost so much weight, I'm in a size below what I was before getting pregnant so I need a few nice pieces for my new size (I can't take credit for this new size, I don't have time to exercise at all :) ). Anwyay, you have inpsired me to look for some bright colors this new season. Thanks for the post :)
Hugs, Christine
Hi, Suzanne. Love the skinny jeans, those would fit perfectly inside my cowboy boots when I go horseback riding. I love the fabulous colors that are showing up in stores for spring, they have lots of punch and you can stand out in a crowd. One of my favorite stores is Dressbarn/Ann Taylor because they both have classy new styles and I need to dress for the office occasionally. I say occasionally because I work from home most days and I am always in jeans and a T-shirt or sweater of some sort. However, my favorite jeans come from Levis at the Prime Outlet stores in Castle Rock, CO. Love my 545 bootcuts.ReplyDelete
Cathy Lee
- AnonymousMarch 4, 2013 at 11:41 AM
I am going to be looking for white as I noticed just yesterday my white items are looking kinda dingy. My go to store is Peebles. Liz S.ReplyDelete
- AnonymousMarch 5, 2013 at 8:26 PM
I've admired your style when i see your pics. Classy and age appropriate but also very cute and fun. Thanks for sharing! ( ((Hugs))) angela mirelesReplyDelete
- AnonymousMarch 8, 2013 at 11:47 PM
Suzanne are the Abercrombie Jeggings a low rise? With bending down with the kids all day I hate showing my booty crack. I have wanted some for my boots all winter but I just don't have the time to shop for myself. I am loving your site, I so can use fashion and organizing tips.. I am a mess!!ReplyDelete
Shelby Goolsby
Thanks so much for visiting me, I hope I made you smile or inspired you in some way! I appreciate you stopping by!


text:
**Please be sure to follow the challenge theme and rules or it will be removed.
DIGITAL DELIGHTS SHOP image Flower Power Daisy, who I have colored with Copics, cut with Lifestyle Crafts die and daubed with Memento ink. I made a little tote bag which I put post-it notes in. I varied the instructions for a 3 x 3 post-it bag that I found on Splitcoast b/c I wanted a larger bag to showcase this cute image. I added brads from Bo Bunny to hold the handle. Papers are SU DP and CS as well as Bazzill CS. I used a Fiskars punch for the handle and the cut outs on the bag. Sure hope you like it and will come play along with us!!