text:
Such active adults have significantly longer leukocyte telomeres (P<0.001) than those who are more sedentary, reported Lynn Cherkas, Ph.D., of King's College London, and colleagues in the Jan. 28 issue of the Archives of Internal Medicine.
In a study of white twins, the leukocyte telomeres of the most active participants were 200 nucleotides longer than those of the least active (7.1 versus 6.9 kilobases, P=0.006), they said.
"This difference suggests that inactive subjects may be biologically older by 10 years compared with more active subjects," they said.
"However," wrote Jack Guralnik, M.D., Ph.D., of the National Institute on Aging, in an accompanying editorial, "although shorter telomere length has been associated with cell senescence, its direct effect on organ function is not well documented, and telomere length in postmitotic cells has not been related to life span in the experimental animal in which it has been extensively studied, Caenorhabditis elegans."
The authors wrote that "these findings underscore the importance of health promotion of regular exercise to retard aging and diminish the risk of aging-related diseases."
Dr. Guralnik, the editorial writer, countered that "the association of exercise with telomere length in this cross-sectional study is provocative, but much more work needs to be done to show that there is a direct causal relationship."
He pointed out that "persons who exercise are different from sedentary persons in many ways," and "many additional factors could be responsible for the biological differences between active and sedentary persons, a situation referred to by epidemiologists as residual confounding."
He added that "ultimately, only a randomized controlled trial can provide good evidence about causality."
Telomeres are the ends of chromosomes and gradually wear down with each round of cell replication, thereby shortening with age. Processes like oxidative stress and inflammation -- which increases leukocyte turnover -- can speed up the erosion process, the King's College researchers said.
"Leukocyte telomere dynamics (telomere length and age-dependent attrition rate) are ostensibly a biological indicator of human aging," they wrote.
Leukocyte telomere length is short in oxidative stress-related diseases, like coronary artery disease and diabetes. It is also inversely associated with body mass index, leading the researchers to hypothesize that physical activity level and energy expenditure may play a role in the shortening process.
So Dr. Cherkas and colleagues looked at data from 2,401 white twins (2,152 females and 249 males, ages 18 to 81) in the United Kingdom Adult Twin Registry. The sample involved 167 monozygotic twin pairs, 915 dizygotic twin pairs, and 237 unpaired twins who had measurements of leukocyte telomere length taken.
The participants completed health and lifestyle questionnaires. Physical activity during leisure time over the past 12 months was self-reported on a scale of 1 (inactive) to 4 (heavy activity).
BMI, whether their profession was manual or nonmanual, and smoking, socioeconomic, and disease status were also recorded.
The women were divided into two groups -- those younger than 50 and those 50 or older -- because 50 is the median age of menopause in these twins, as determined in previous studies.
After adjusting for age, sex, and year of DNA extraction, leukocyte telomere length ranged from 4.9 to 9.1 kb with a mean of 7.0 (SD 0.6) kb. It decreased significantly with age (P<0.001).
Increasing BMI (P=0.001), being a smoker (P=0.01), and being a manual worker (P=0.02) were significantly associated with a shorter age-adjusted leukocyte telomere length.
The adjusted longer leukocyte telomere length was associated with increasing leisure-time physical activity (P<0.001). This correlation was not significant for men (P=0.27) but was significant for women (P<0.001). "There was probably insufficient power to detect a significant association in men because of the small sample size (n=249)," the researchers wrote.
The positive association also remained significant in women after splitting them into two groups -- P<0.001 for women under 50 and P=0.04 for women 50 or older -- to examine the effects of menopause.
After adjusting for BMI, smoking and socioeconomic status, and physical activity at work, the association between leisure-time physical activity and leukocyte telomere length was significant at P<0.001.
To partly account for the influence of genetic, cohort, or shared early life effects, the researchers examined the correlation in twin pairs with differing levels of physical activity between siblings, defined as at least a two-point difference on the physical activity score. In 67 twin pairs who qualified, the difference in leukocyte telomere length between the more active twins and less active siblings was 88 nucleotides (P=0.03).
"The relationship between physical activity level in leisure time and [leukocyte telomere length] suggests that a sedentary lifestyle, low [socioeconomic status], high BMI, and cigarette smoking share metabolic pathways that incrementally affect leukocyte telomere dynamics," the researchers said.
Most likely, oxidative stress and inflammation are responsible for these effects, they wrote.
Paradoxically, they continued, exercise decreases some oxidative stress-related diseases, but increases oxidative damage. The authors suggest hormesis theory, which states that there may be beneficial effects of low doses of harmful substances, as a possible explanation.
"Therefore, the longer [leukocyte telomere length] associated with increased physical activity level may be mediated through an overall diminished burden of oxidative stress and inflammation," they wrote.
The authors acknowledged that the study was limited by the self-reported nature of the data and the fact that there was likely a large variation in exercise frequency, duration, and intensity within each of the four physical activity levels.
|The study was supported in part by grants from the Wellcome Trust, the NIH, and the Healthcare Foundation of New Jersey.
Neither the researchers nor Dr. Guralnik, the editorial writer, reported financial disclosures.
Reviewed by
Zalman S. Agus, MD Emeritus Professor
University of Pennsylvania School of Medicine
Primary Source
Archives of Internal MedicineSource Reference: Cherkas L, et al "The association between physical activity in leisure time and leukocyte telomere length" Arch Intern Med 2008; 168: 154-158.
Secondary Source
Archives of Internal MedicineSource Reference: Guralnik J, "Successful aging: is it in our future?" Arch Intern Med 2008; 168: 131-132.


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According to Engadget existence of White iPhone 4 has recently appeared in Vodafone Germany's inventory system.Entries for both 16GB and 32GB versions of a "weiß" ("weiss," or white) version showed up alongside the usual black ("schwarz") versions.
Last we'd heard, the rarest member of the iPhone 4 clan was tracking for a spring '11 launch — and that'd line up pretty nicely with shots we've received from a trusted source today showing new entries in Vodafone Germany's inventory system for weiß (white) iPhone 4s in both 16 and 32GB flavors. Of course, this doesn't necessarily mean Vodafone has any idea when these phones are showing up on their doorstep — maybe they're just preparing (and hoping) that it materializes before too long — but for what it's worth, the source says to expect a launch "soon."
It seems then that if these latest snippets about a White iPhone 4 being listed turn out to be a red herring, we may not see one until a White iPhone 5 comes along, that is of course assuming that Apple plans one.No wonder what Apple is thinking at the moment!


text:
Sept. 2008 to August 2010
The Firesign Theatre are now on Twitter @FiresignNews. Get Firesign events, announcements and breaking news before it happens.
Phil Proctor was the guest narrator for "The Ingenious Gentleman Don Quixote: Words and Music From the Time of Cervantes." Locations included Whittier (Calif.) College, Northwestern University, University of Richmond, and the 92nd Street Y, New York City. Music by The Los Angeles Guitar Quartet.
The Firesign Theatre had an outstanding performance on April 24, 2009 at the Golden State Theatre in Monterey, California, celebrating Nick Danger's 40th birthday! Check out Bob Hardy's website with Monterey pictures.
In honor of the April 24th Firesign show, here's a brand new Philbert cartoon, exclusively for Chromium Switch.
Ken Gammage sent along this review of Bozos from 1972.
Starting with his recollection of L.A. radio in the 60's, and continuing through the genesis of Radio Free Oz, Firesign cartoonist Phil Fountain writes about the Box of Danger collection.
From KPFK comes an interesting artifact that appeared in their publication The Folio.
Grandpa Proctor...News from Phil about his Grandson: "Bowen Gordon Campbell was born at 10:56 pm on November 25, 2008 by midwife at the UCLA birthing center in Westwood, California. He weighs 8 lbs. 14 oz. and was delivered in a little over 2 hours and 12 hours later, Melinda and I visited Geoff and Kristin in the "left" wing of the Ronald Reagan Building. Bowen is named after Geoff's great-great grandfather who started the Canadian Royal Mounted Police, so as a Canadian, he knows a lot about mounting."
Latest news from Phil Proctor... "I recently did a small, fun part as an alien in a short webflick called Intervention, and a silly Englishman for the "Gorgeous Tiny Chicken Machine Show" for Greg Benson's Mediocre Films which should be up soon. I've also been promoting the just released Firesign Theatre "Box of Danger" 4-CD set on Shout!Reprise Records and recently was interviewed by Jim Svejda on KUSC-FM for his Halloween Special and his annual upcoming New Year's eve show. I also appeared in a put-on about Sarah Palin on Thom Hartmann's AirAmerica program. But most important, I'm waiting for daughter Kristin to give birth to my first grandson!!!"
Special thanks to Phil Proctor for mentioning Chromium Switch in his latest Planet Proctor.
Temporarily Unleaded County. The Firesign Theatre's Big Mystery Joke Book is in the collection of the library at King Fahd University of Petroleum and Minerals in Dhahran.
The Firesign Theatre's Box of Danger: The Complete Nick Danger Casebook turns the spotlight on the legendary comedy troupe's most famous creation: Nick Danger, Third Eye. This 4-CD box set assembles for the first time such legendary skits as "Cut 'Em Off at the Past," "The Case of the Missing Shoe," "The Three Faces of Al," plus a wealth of rare and unreleased items from Nick's tattered casebook.
Phil Austin has posted The Regional American Surrealist Cookbook at The Big Jewel, an archive of literary humor.
Glen Banks, a Dear Friend of Firesign, has appeared on several albums including Next World, Eat Or Be Eaten and Boom Dot Bust. As Firezine's Freditor describes him "...television producer, Firesign peripheral, and Dendrolator," Glen has posted some hereforto unseen photos at Uncle Glen's Lounge Party.
Highway 61 Revisited: The Tangled Roots of American Jazz, Blues, Rock, & Country Music. Gene Santoro (The Nation, The Washington Post) is a music critic whose 2004 book includes an entire chapter devoted to The Firesign Theatre. It's a concise "mini biography" that begins circa Give Me Immortality or Give Me Death.
What happens if you take old Ed Wood footage, old stock footage, new amateur footage, and cut it into something resembling unfilmed stories by Ed Wood and mix in narration by Phil Proctor? How about Devil Girls and The Vampire's Tomb.


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Have you ever been somewhere, listening in on a conversation (or possibly trapped where you are forced to listen) and wish you could jump in regardless of the consequences? Well, this happened to me this morning. And not being able to respond at that time, I now present just my side of the conversation with the adult voice from the Peanuts filling in the other side:
So you honestly think that a being capable of creating space, time, and matter, 125 billion galaxies, of which there are 400 billion stars and 4 trillion planets in our galaxy alone, with 1.8 million known living plant and animal species on this planet (several billion if you count the extinct ones), and you think that this being thinks YOU are important? Oh please, get over yourself. You aren't cosmic shit. You are not special by any stretch of the imagination. And if there is a divine being, it would have the power to create something infinitely more interesting than you.
Died for your original sin?!?! What sins does a baby have? What kind of horrible being do you think would create a life already convicted of the worst crimes that can be imagined? How horribly cruel is that being that you're calling a God?!??
Look, I understand that you think that there is a super-cool guy out there in the sky who controls everything, but there is an old argument by some dead dude that goes something like this: If your God wants to stop evil, but can't, then he is not all powerful. If he can prevent evil, but is not willing, then he is cruel. If he is able and willing, then evil wouldn't exist. If he is not able or willing, then he isn't actually a God. See how easy that was? No God, you're on your own. Sorry.
Fine, fine, whatever, I look at it this way: The same freewill that allows you to believe in a supernatural being is the same freewill that allows me to behave myself. You choose to believe in a fantasy world because you think that its rules are sacred. I use my freewill to believe in rules for the sake of humanity and to keep myself safe. Either way, we are basically supporting the same rules. Except with my way, I can change my rules as science, morals, and technology evolves. You are now stuck because you've chose to submit your freewill to something that is uncompromising and your freewill no longer exists while it is in sublimation to that divine law. Therefore, I can choose to be a better person then you because I can take in more factors and current judgments about present day situations.
Same to you.
There, I feel much better now. Thank you.
My blog contains a large number of posts. A few are included in various other publications, or as attached stories and chronicles in my emails; many more are found on loose leaves, while some are written carelessly in margins and blank spaces of my notebooks. Of the last sort most are nonsense, now often unintelligible even when legible, or half-remembered fragments. Enjoy responsibly.
Saturday, May 19, 2007
Entry for May 19, 2007
Posted by Brian Hamilton at 1:58 PM
1 comment:
- jus'surfin' said...
You're welcome :)
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Associated Names: An Insatiable Passion
Author: Lynne Graham
Artist: HOSHIAI Misao
Status in Country of Origin: 1 Volume (Complete)
Year: 2006
Kitty was left heartbroken after her affair with Jake, who was far above her status. After spending their first night together, he suddenly seemed to become a different person, and then married another woman! "I'll never come back to this place," she vowed. Time passes and Kitty makes it big as an actress. However, hearing of her grandmother's death, she returns to her hometown for the first time in 8 years, only to bump into Jake! "You finally came back," he said. Jake, a man who left a deep scar in her heart... But why does her heart flutter when she sees him?
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