text:
The dispute between the parties arose from an alleged failure by Mercer (the defendant) to correctly carry out an amendment to a defined benefit pension scheme to effect equalisation between men and women. That alleged error led to an increased funding liability for the scheme.
The dispute related to events which took place between 1990 and 2001. In 2000, the principal employer of the Britax Pension Fund (the "Fund") was sold to the first claimant, Seton House Group. The trustees of the Fund, Britax Pensions Trust Ltd, were the second claimant. At all material times Mercer, the defendant, provided actuarial and investment services to the Fund.
In 1990, Mercer recommended that the normal retirement age of all future employees should be raised to 65 (previously it was 65 for men and 60 for women). An explanatory booklet and communications notifying members of the equalisation of retirement ages with effect from 1 April 1991 were issued. However, it was not until a deed of amendment in 2000 that the Fund's trust deed and rules were amended to effect equalisation, despite Mercer allegedly advising the Fund on a number of occasions between 1990 and early 2000 that equalisation had taken place in April 1991.
In 2000, a subsidiary of the principal employer (and a participating employer in the Fund) was sold to a third party purchaser. The purchaser's accountants produced a financial due diligence report which dealt, in part, with the Fund. The report identified that, although normal retirement age for men and women had apparently been equalised in accordance with the legislation, the communications to members differed from the amendments to the scheme and were not in accordance with the legislation and that equalisation had, in fact, been ineffective.
In litigation commenced in 2011, the claimants argued that Mercer had provided negligent advice that equalisation had been effective in 1991.
Mercer denied liability and, in addition, raised a defence based on the Limitation Act 1980 (the Act). The standard limitation period in relation to negligence claims is six years from the negligent act, however, section 14A(10) of the Act extends the limitation period for "latent damage" claims in negligence, so that the period runs for three years from the date at which the claimant knew, or reasonably ought to have known, that negligence had occurred. The claimants argued that this exception applied to their claim, thus allowing them to commence proceedings more than six years after the negligence had occurred.
Mercer applied to the court for summary judgment, arguing that the accountants' report from 2000 had come to the attention of the claimants and had provided them with sufficient information about the possible negligence such that the three year limitation clock started running at that stage. Thus, Mercer argued, the limitation period within which the claimants were required to bring their claim had expired.
The application was successful and the claim was dismissed. The claimants appealed against this decision, but the High Court dismissed their appeal, holding that, in a situation such as this, it is necessary to establish:
- what the claimant could himself have ascertained about the potential claim; and
- whether, in light of that, it would have been reasonable for him to carry out further enquiries which would have led to additional knowledge about the potential claim.
The claimants argued that they did not look at the accountants' report to see what concerns had been identified in the context of the sale, and that they could not reasonably have been expected to do so. The High Court dismissed that argument, stating: "…given the importance of the transaction and the significance of the report, the conclusion that both the claimants could reasonably be expected to look at its content was inevitable. It would have been slapdash not to do so… Pensions and the transfer from the pension fund were material parts of the transaction and it was inevitable that the seller, and the trustee, could reasonably be expected to review what the purchaser has discovered in relation to its due diligence."
It was held that the contents of the report, and thus the concerns raised by the accountants which cast doubt on whether the equalisation was effective, fell within the scope of the constructive knowledge of the claimants. It would, therefore, have been reasonable to expect the claimants to subsequently take advice and carry out further investigations into the issue.
Lessons to be learned
This case is yet a further example of the extensive and costly litigation that has followed the Barber equalisation decision. More broadly, it is also a salutary reminder to trustees and employers to carefully consider documentation produced as part of any transaction or due diligence exercise, and to take further advice if necessary. If reports which consider pension issues have been prepared and handed over to trustees and
employers, the recipients will be deemed to have constructive knowledge of their contents and will subsequently be prevented from adopting a "head in the sand" approach in order to argue that they were not furnished with sufficient knowledge.
Seton House Limited and Britax Pensions Trust Limited v Mercer Limited


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Factors to Consider When Going for Plastic Surgery
Plastic surgery for a long time has been considered to be one of the most important and most beneficial surgeries ever invented. This is due to the fact that it give somebody an opportunity to be able to change their looks to the better and look more lovely. There are quite a number of people who have esteem issues that arise from how they look or even some part of their bodies that could be having some disorders. For this kind of people, it is always important that they go for plastic surgery because it happens to be very beneficial in trying to correct some part of the bodies that may make you feel uncomfortable or even feel you are not accepted in the community. To learn more about Plastic Surgery, click
breast augmentation
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We had two comments in a prior thread which are suggesting something new to me. Either that or we are exploring, yet again, the dark underbelly of career transition and it is important to understand it and make it work for you. Instead of letting it get you down.
msphd noted:
even if my scored-but-unfunded K-grant proposal were suddenly back in for reconsideration, I would still have the problem that my university doesn't want to give me a job title that NIH would find suitable enough.
to which I responded:
Something doesn't add up.
Why would msphd's institution submit the proposal on her behalf then refuse the promotion? Now if it was a promotion contingent on the award, that would be familiar...but then this comment wouldn't make any sense.
another person agreed with msphd:
I'm in the same boat. As a postdoc, one can apply for a K-award through my institution. But they ain't promising a promotion contingent on the award. Not to everyone who applies, anyway.
Strolling on over to the NIH's K Kiosk I found the following graphical representation.
So we need to be a little clearer about what we are discussing. The minimally utilized K22 and the new-ish K99/R00 or the traditional K01? Usually when someone refers to a K, unmodified, I'm going to assume the K01. The K99 is awarded to postdocs by design so it seems unlikely we are talking about this one.
The K01 should be awarded to someone with an independent scientist type appointment. Which is not the same as an Assistant Professor slot. So if you are expecting this latter to come with a K01 award, well, that isn't obligatory. The University may, however, use one of an unending word salad of titles such as Adjunct Assistant Professor, Assistant Professor in Residence, Assistant Professor of -ology, as their non-tenure track titles for an independent scientist. Some may simply use Research Associate, Research Scientist, Project Scientist or other descriptor. Just so long as the position is arguably a real job with nominal independence from any other professor at the University, all is well. So far as awarding the grant goes anyway because (repeat after me) the NIH grant is awarded to the institution, not the PI. Well, okay, K-mechs are a little more arguable but in the pre-award phase the point is that anyone is qualified if the institution says so. NIH doesn't care what the local name for the position is.
Now, I don't know if msphd's original comment referred to this situation or not. But it would not be at all unusual if the offer of the nominally independent position depended on the grant award. So, if I read her comment right, the institution isn't "refusing", she just hasn't fulfilled the other side by getting the award funded. It would also not be unusual, IME, for the institution to have changed policies once or twice between submission of the K-mech and the present. This is why I suggest that anyone involved in these contingent offer situations get as much as possible in writing. I have seen more than one person secure their position under changing institutional policies because of the paper trail (and suitable ranting from supportive Full Professors, of course).
Other than that...???? Are you all really hearing of places that allow K01 submissions and never intend for you to receive it at their institution? Are they expecting you to do this as a trial run, or to get a leg up, while you are getting a job elsewhere? This is all very foreign to me if so....


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Date Joined: November 6, 2008
Last Online: July 19, 2010
Birthday: September 8
Country: Philippines
My Website
i am mommy's first apo ichigo's all ado's cousin jessica z's twisted minion devi(l)rella's frienemy eldin's princess manok's daughter
i am ocean defender social experimenter spice lisianthus clerk rebel with(out) a cause veigha
i am ice cream junkie pizza nut adventure glutton movie-savant/librarian wannabe list fiend
i am romantic cynic hopeless dreamer thankless noncomformist kept vagabond
i am cleft-chinned pug-nosed big-ear(ed)
i am feisty curious
i am me
i think books are a lot like people, they number over a billion, and can be placed in fixed sets and same categories, but can be as diverse as the gazillion stars in the milky way, so in the same way that i could list people who affected me when i was younger, i could also list books that affected me as a kid, i memorialize hope for the flowers, nicaragua for beginners, lenin for beginners, economists for beginners, ikabod bubwit, hagar the horrible, gapo, nancy drew, the hardy boys, jonathan livingston seagull, heidi, adventures of tom sawyer and huckleberry finn, anne of green gables, the joy luck club's prologue-the thing about the feather, five find outers and a dog, boxcar children, adventures of sherlock holmes, edgar allan poe's scary stories, twisted, and my mom's collection of reader's digest from before i was born, i swear i read all of these by the time i was 9, blame it on an aunt who thought a very young bookworm was amazingly adorable, or blame it on my asthma
i love movies, they're like portals to alternate and parallel worlds and times, they let me live my secret lives without having to go through the looking glass like alice, i enjoy movies so much i watch anything and everything that isn't r-rated, but of course, like the comfy overlarge shirt i "inherited from my aunt or the batik pj's i had since elementary, there are also movies with not so great storylines, acting, and credits, that i would still watch over and over again, if i can have comfort food then here are some of my comfort movies, aladdin, peter pan, the lion king, mulan, 101 dalmatians, the lord's edges, conair, under the tuscan sun, seabiscuit, never been kissed, notting hill, eternal sunshine of the spotless mind, shanghai noon, the emperor's club, the italian job, ocean's 11, who am i, corpse bride, kurtlar vadisi irak, big fish, shrek, the gods must be crazy, and chocolat, i've also recently (3 years ago) developed a penchant for indie films, pinoy or otherwise... only you (not the one with pinoy actors, but the one set in italy)
i don't have my own particular brand of music, i go for whatever fits my mood, but i have this tendency to not like whatever genre is in, but i like most of the "classics, songs by the likes of james taylor, barbara streisand and paul williams, maybe because i grew up listening to them in the car while being driven to and from school, i like evanescence, sixpence none the richer, and no doubt, i also like s club 7, the corrs and atomic kitten, i love panic at the disco!, my chemical romance, the all american rejects and maybe, the dave matthews band, and absolutely adore selena even if she's dead, in the local scene, i have a liking for "older bands, like yano and its santong kabayo, wonder whatever happened to them, the eraserheads and parokya ni edgar, rivermaya i also like rocksteddy, and kamikaze, and i've always been a fan of the ambassadors, and i've recently discovered tropical depression, but because they're what's in, i've become so into tori amos right now... and into all types of asian pop too
hello all, i just want to warn you ahead that my international mail averages 30 to 45 days before it reaches anywhere... on record, earliest it's reached anybody is 22 days, latest is around 3 months... please don't ask me why this is so, 'cause frankly i think only the people in the post office knows (or do they?)... please have faith in me when i click the sent button, i would never never click the sent button unless i've already really sent the swap item, so please trust me a bit, and pardon me for the limitations of my country's postal service... n_n
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Your letter arrived yesterday. Not sure what happened to it on the way to me but it just came in the mail yesterday and it was amazing. Thank you for sharing it with me.


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Beautiful ballad taken from their latest album.
By Blurt Staff
Hard-twangin', fuzzbox-stompin' guy/gal duo Hymn For Her have been a fixture on the American and Euro roadways the past few years, touring behind their blistering 2013 album Lucy and Wayne's Smokin' Flames and the more recent revved-up Drive Til U Die (listen to it at their website). Yeah, that band, the one touring in a deluxe Bambi Airstream, which did double duty as a recording studio for DTUD, along with studio sessions with the likes of Vance Powell, Mitch Easter & Jim Diamond. Now Lucy and Wayne have got a new video from the album to share, at their YouTube channel. just in time for all you sweethearts and Valentine's Day – bask in its luminous glow, and feel free to sing along as you allow us to give you an advance peek. Check out "Acetylene":
According to Lucy, "'Acetylene', it's about the vast circle of life & sharing those moments with ones we love along the way. It was inspired in Menomonie, WI, written in Beaver Island, Mich., recorded in our 1961 Airstream in Swampville, FL, mixed by Mitch Easter (of REM engineering fame) in Kernersville, N.C. and mastered in Nashville, Tenn. It's on our last release, Drive Til U Die.…so the song has had quite a journey. Our daughter joins us singing harmonies at the end."
She adds that a new album is currently in the works, saying, "We recently finished working on a full length CD with Vance Powell that will be released at the end of August 2018. We are beginning to work on a video for the first song on the album in February. The songs on this release are a variety of many styles and many emotions, all played by the two of us."
The band kicks off a new round of touring this week, starting Feb. 16 in Sarasota, FL. Just look for the music venue with the Airstream parked beside the load-in doors. Tour dates at their website.


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The average rate on the popular 30-year fixed mortgage has been so low for so long that a good chunk of borrowers can't even contemplate the idea of it ever going higher.
Why should they? Every time we warn of rising rates, or see a tiny bump up, some global economic tantrum pushes them back down. Most borrowers have refinanced to take advantage of these low rates, but, strangely more than 1 in 10 have not. These borrowers have rates above 5 percent, while the rest of us sit around 3½.
If you really want to get technical, almost one-quarter of borrowers have rates above 5 percent, but a lot of them cannot refinance. CoreLogic economist Molly Boesel ran the numbers and found the following reasons why so many are shut out of the savings.
First, about half of the mortgages with the highest rates either are or have been delinquent at some point, and that means lenders will not refinance them to the lowest rates. The risk is simply too high.
Second, mortgages that are held in private-label securities are much harder to refinance than loans backed by the government. After the housing crash, the government instituted streamlined refinance programs, which included underwater borrowers. That takes the share of borrowers who are missing out down to 13 percent.


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Digital Newsletter & Web Advertising Specs
|Ad Type
|Website Ad size (W x H in pixels)
|Newletters Display Ad size (W x H in pixels)
|916 x 236
|602 x 155
|Super Leaderboard
|916 x 85
|602 x 56
|Super Skyscraper
|244 x 488
|220 x 440
|Square Tile
|244 x 244
|220 x 220
Production Requirements for Digital Ads
Advertising creative/graphics must be supplied:
- two weeks before publication
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- 150 to 200 words of copy
- Low-resolution static visual, .jpg or .png and not more than 100 KB, typically around 300 x 250 pixels.
- A URL to where the client wants to direct the viewer. Advertiser also can anchor the URL to content on our website.
Direct Email Promotions
Client supplies content formatted for HTML delivery to selected segments of our database to reach from 1,000 to 48,000 subscribers.
HTML design should be no wider than 600 pixels, all external links fully functional and all images must reside on a publicly accessible web server.
Custom Newsletters
Our team can help yours create a custom targeted e-newsletter to reach your clients and/or segments of our subscriber database.
White Paper
Objective researched white paper(s) that responds to a specific issue, with a research bibliography, website links and an about the sponsor information.
Other Media Options
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- Conference & Trade Show promotion
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- Conference Match-ups
- Industry Insights Call-In: listen to industry experts/thought leaders discuss impactful topics.
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- Social media (Twitter, LinkedIn): support for client information dissemination (Twitter, Facebook and LinkedIn)
- Direct print mail: creative production, printing and mailing available.
Advertising Creative Materials
Please send all ad creative materials and urls to:
Mayank Agarwal
Advertising Questions?
Apolline Tridon, Account Director
Michael Walsh, Publisher
(973) 885-8283
Editorial Content
Please send all editorial content to:
Theresa W. Giarrusso, Editor
Newsletter Ad Placements
Please see the example below to get an idea of how ads might be placed within our newsletters.


text:
Diverse product pipelines, new facilities, continued process improvements and the pressure to reduce costs through outsourcing is changing the way industry manufactures biotherapeutics.
CHI's Inaugural Manufacturing and CMC Strategies for Biologics meeting discusses the latest challenges in developing novel manufacturing strategies,
product lifecycle management and improvement, single-use systems and standardization, and CMO management.
Final Agenda
Monday, August 15
8:00 am Short Course Registration
9:00 – 11:30 Recommended Morning Short Course*SC3: New USP Initiatives and Standards for Biologics
* Separate registration required
11:30 Main Conference Registration Opens
1:00 pm Chairperson's Opening Remarks
Jeffery Odum, Global Technology Partner, NNE Pharmaplan
1:10 Single Use Technologies and Implementation for Biomanufacturing: The Design Manager's Challenge
Jeffery Odum, Global Technology Partner, NNE Pharmaplan
As companies develop both short and long-term manufacturing strategies, operational efficiency and utilization become very critical to optimizing cost-of-goods, manpower planning, and supply chain management. This article will provide insights into the
challenges faced by Design Managers implementing new single-use technology platforms and the sometimes unforeseen issues they face. The topics will include defining the process and optimizing time-and motion analysis, equipment definition and platform
technology analysis.
1:45 KEYNOTE PRESENTATION:Developing Practical Single-Use Processes for New Vaccine Formulations
Kirsten Strahlendorf, P.Eng, M.Eng, Senior Scientist, Sanofi Pasteur Ltd.
In order to successfully implement a new vaccine formulation process using closed system, single-use technologies, both end-user process and study design require careful thought and execution. This presentation will review some of the aspects of filtration,
mixing, formulating and dispensing that can impact homogeneity, adsorption, concentration and other critical product attributes.
2:15 Setting Standards in Single-Use Systems: Update from SUTAP, The Single-Use Technology Assessment Program
Alain Pralong, Ph.D., Senior Vice President, Manufacturing Operations, CellMedica
The shift from traditional to single-use technology is changing the distribution of responsibility and accountability within the drug manufacturing value chain as more components are procured ready-to-use without further modification by the end-user meaning
the effective drug manufacturer. This presentation will outline how the creation of SUTAP – the single-use technology assessment program – has progressed, where we stand today and give a comprehensive overview on the next steps.
2:45 Refreshment Break
3:15 Analytical Testing Strategy to Support Kadcyla® / T-DM1 Manufacturing Process Validation for Supply Chain Optimization
Dai, Ph.D., Associate QA Scientist, Global Biologics Quality Control, Genentech/Roche
Cleaning Validation is a key step to de-bottleneck during manufacturing site transfer. The complexity is increased for ADC product where the cyctotoxic residuals must be removed to be below a pre-determined Maximum Allowable Carryover level after
equipment cleaning. A holistic approach has been used in designing the QC testing/validation strategy, including considerations to link downstream analytical testing to the particular cleaning process and to ensure compliance in accordance to
local CMO and company network practice..
4:00 An Integrated Platform for Mass Production of Immunotherapy Applications
Robert Dream, Ph.D., Consultant
Thus far using gene-modified cells has mainly been carried out by investigators who have developed their manufacturing process for small scale clinical trials by using the devices and infrastructure at hand. Anyone who has embarked on the task of
manufacturing patient-specific advanced therapeutic medicinal products (ATMP) for clinical use will admittedly agree that it is quite an undertaking.
4:30 Breakout Discussions
This session provides an opportunity to discuss a focused topic with peers from around the world in an open, collegial setting. Select from the list of topics available and join the moderated discussion to share ideas, gain insights, establish collaborations, or commiserate about persistent challenges.
Facilities of the Future Moderators: Jeff Odum, Director, Operations and Biotech Lead, IPS
CMC Strategies for BiosimilarsModerator:Beatrix Metzner, Ph.D., Director, Global CMC Strategy & Tech RA, Boehringer Ingelheim Pharma GmbH & Co. KG
5:30 Grand Opening Reception in the Exhibit Hall with Poster Viewing
7:00 End of Day
Tuesday, August 16
7:30 am Registration Opens and Morning Coffee
7:55 Chairperson's Remarks
Franqui Jimenez, Ph.D., Senior Director, Head of Manufacturing Science and Technology, Genzyme
8:00 Application of Advanced Manufacturing Process Strategies and Analytical Tools for Increased Process Throughput, Improved Product Understanding, and Efficient Process Control
Valerie Tsang, Ph.D., Senior Engineer III, Technical Development, Biogen
In order to meet the potentially high commercial demand for some biologics programs, manufacturing process changes are often necessary during the late stages of clinical product development. To accommodate the anticipated market needs
while maintaining consistently high quality products comparable to those used in early phase clinical studies, Biogen has developed and implemented a series of process technologies and analytical tools to increase productivity and
throughput, improve process consistency and product understanding.
8:30 Emerging Process Trends in Biologics Development and Manufacturing
Kumar Dhanasekharan, PhD, Director of Process Development, Cook Pharmica LLC
Process Development and manufacturing for recombinant proteins, particularly, in a CMO, needs to be strongly connected together due to tight timelines that are tied to client expectations, which is in turn is driven by speed to clinic.
In development, this translates to incorporating new process technologies that align with manufacturing and facility fit needs and concerns. For example, there is a significant need to debottleneck downstream operations due to increasing
titers and higher cell densities in cell culture processes. This talk will showcase case study data from multiple emerging downstream technologies that provide overall process intensification across novel harvest clarification technologies,
high capacity resins and membrane technologies. Additionally, an upstream process intensification development approach with a N-1 Perfusion option will be discussed which can leverage the improved debottlenecked downstream process.
9:00 Considerations for Implementing a Development Laboratory to Support a Legacy Product
Gregory Walsh, M.S. Associate Director Manufacturing Sciences and Technology Laboratory, Genzyme
When improving upon a legacy process an understanding of the history and the past regulatory strategy of the product should be well understood. However not all legacy products have all the information available that meet current best
practices. Lifecycle management of legacy products require continual process knowledge building, manufacturing support, and process improvements which may require regulatory filings. This case study presents the implementation
of a development laboratory solely dedicated to a legacy commercial product that is capable of support all aspects of manufacturing and analytics.
9:30 Sponsored Presentation (Opportunity Available)
9:45 Coffee Break in the Exhibit Hall with Poster Viewing
10:30 Biosimilars Manufacturing Strategies: Can New Entities, CMOs and Others Effectively Compete with Big Bio/Pharma?
Eric S. Langer, President and Managing Partner, BioPlan Associates
11:00 Choosing between Patent and Trade Secret to Protect Bioproduction Methods
Paul Calvo, Ph.D., Director, Biotechnoogy Group, Sterne, Kessler, Goldstein & Fox P.L.L.C.
With estimates that approximately $65 billion worth of biologics will be coming off patent by 2020, the choice of trade secrets versus patent protection has taken on renewed importance in the biotechnology sector. This talk will dicuss
choosing between patent and trade secret to protect bioproduction methods.
11:30 CMC Challenges in Practice: Comparability vs. Similarity
Beatrix Metzner, Ph.D., Director, Global CMC Strategy & Tech RA, Boehringer Ingelheim Pharma GmbH & Co. KG
The impact of manufacturing changes is well understood by means of comparability exercises. Mostly analytical testing is sufficient. The establishment of biosimilarity requires a comprehensive analytical comparability exercise very sensitive to differences and allows determining if a proposed biosimilar is shown to be "highly similar". Therefore the scientific principle of a biosimilarity exercise is based on the comparability approach.
12:00 Regulatory CMC for Biosimilars: The Comparability Exercise
Richard DiCicco, Chairman, Harvest Moon Pharmaceuticals USA
For the approval of biosimilars, a meaningful "Finger-Print"-like analysis algorithm is needed to demonstrate similarity of the biosimilar product to the Reference Product. This presentations looks at a stepwise approach starting with analytics to prove highly similar physio-chemical attributes, batch-to-batch variability of the quality attributes of the Reference Product and analytical structural characterisation for biosimilar comparability.
12:30 Luncheon Presentation (Sponsorship Opportunity Available) or Lunch on Your Own
1:15 Dessert Refreshment Break in the Exhibit Hall with Poster Viewing
1:55 Chairperson's Remarks
2:00 Latest Developments in the US Biosimilars Market
2:30 Accelerating Timeline to IND by Using Pool for Tox Strategy
Wendy Hsu, Engineer and Group Leader, Early Stage Cell Culture, Genentech
Speed to IND submission is essential in establishing a competitive advantage for a therapeutic product. CMC activities are often on the critical path to IND-enabling toxicology (Tox) studies. The use of a "Pool for Tox"
strategy where a pool of clonally derived cell lines is used instead of a single, clonally derived cell line to generate Tox material, can accelerate timelines by several months. The success of the strategy relies on the ability
to generate comparable Phase I material using a single, clonally derived cell line.
3:00 A Client's Perspective- Developing an Accelerated Timeline to File an IND
Deborah Meshulam, Ph.D., Director, Contract Manufacturing, Scholar Rock
Scholar Rock has developed proprietary technology based on new insights into the structural biology and activation mechanisms of protein growth factors. The process of developing and manufacturing antibodies which can modulate
these growth factors can be accelerated to file an IND using a GPEx technology cell line. In this presentation, key parameters and potential risks will be identified and discussed.
3:30 Refreshment Break in the Exhibit Hall with Poster Viewing
4:15 Novel Stability and Concentration Enhancing Formulations for Improved Administration of Biotherapeutics
Neil Schauer, Ph.D., Advisor, ReForm Biologics
The current trend in biologic drug delivery is towards development of formulations that enable room temperature stable, high protein concentration drug products in prefilled syringes and auto injectors. This trend requires novel
formulation strategies. This presentation addresses product viscosity and stability issues for the improved administration of biotherapeutics.
4:45 Facilitating the Design of Recombinant Protein Therapeutics with the Aid of Comprehensive Genomic Codon Usage Data
Chava Kimchi-Sarfaty, Ph.D., Principal Investigator, Hematology, FDA/CBER
Codon usage is an active area of research that plays a major role in the expression and folding of proteins, and is especially important in the creation of recombinant therapeutics. However, genomic codon usage data is outdated,
inaccurate, or unavailable in existing databases for many organisms, limiting opportunities for research. We are creating a new database to provide codon usage data for every available organism.
5:15 End of Conference
5:15 Registration for Dinner Short Course
6:00 – 8:30 Recommended Dinner Short Course*SC5: Analytical Strategies for Comparability in Bioprocess Development


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Hi there penguins!
Today, a new Field-Ops has been released for Elite agents to complete to retrieve medals! First, you will need to head down to the Command Room to receive your mission!
Herbert has transmitted us Protobot's and the Test Bot's current location - in the woods north of the Cove. Move into position, and take them offline. Use tactical H20 cannons, which are only dangerous to robots.
Next, head to the Cove and waddle to the section of the Cove inbetween the top and the right-hand side.
Then, you will need to destroy the targets! Enter the x y coordinates to fire the defense cannons. Aim for the red targets. Stay focused - you must destroy twenty targets in time.
After you have finished your Field-Ops, you will see this message from Protobot.
BZZZZZZZZK - ERROR. SEVERE WATER DAMAGE DETECTED. INTERNAL CIRCUITS COMPROMISED. SYSTEMS SHUTTING DOWN. MUSt... EscaPE - BZZZZZZZZZZZZK.
Good job agents!
-Frosty Badge


text:
LCI Paper Co., Inc.
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Seashell Personalized Goodie Bags
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Send your guests home in style with these seashell themed favor bags. Whether you are having a beach wedding or birthday party, these bags are easy to customize for your event - choose your colors, your font, and enter a line of text and a date. That's all there is to it! Bags are 4 1/4 wide x 8 tall x 2 3/8 deep, are made of quality, reinforced paper and feature crisp, sharp printing.


text:
I can't believe how quickly June is flying by! We've finally gotten honest to goodness summer weather, so we are revelling in the season.
Long flowy and flowery dresses, patios filled with all the pretty people, and the traffic! Yes. Toronto in the summertime means even MORE traffic on our already congested streets. With all the festivals, sports events, street fairs, marathons and bike races, and extra tourists, us locals actually kind of dread going into the downtown core. It takes twice as long to get anywhere, and forget finding a decent parking spot. But I guess I just described NYC at any moment in time, so I'll shut my mouth now!
Cooking takes on a totally different feel as well. On the really hot days, I really lose all ambition. Then it's just some form of grilled meat and a salad. Of course, the produce right now is amazing! Just the other day I came home from the farmers market with fresh peas, breakfast radishes, string beans, mizuna, mustard greens, scapes and asparagus. So for the most part, I find Jim with his head in the fridge, just snacking on all the fresh veg!
It's the perfect time for ice cream. And I love it when I can find a fresh take on a recipe. This one is just that. Not only is it a fresh flavour combo, but even the method has a slight twist to it. At least for me. I was so happy to find this recipe in 'How to Eat a Peach' by Diana Henry. Pink Grapefruit and Basil. What a totally fresh and summery flavour! And with all the basil at the markets (and in our gardens) right now, it just seemed like the perfect time to make it.
I love how Diana has us take the grapefruit zest and pound it with sugar in a mortar and pestle. This gets added to warmed milk, along with shredded basil leaves. It infuses for a few hours. She then has us strain the milk and add it to beaten egg yolks. I won't lie, I did remove the leaves, but after I had strained the milk, I added a bit of the strained zest back in. I just love the extra texture and grapefruit oomph it would give.
Once everything is heated again and turned into a custard, it gets cooled down. While it is cooling, whip up cream to soft peaks. This gets folded into the cooled custard. At this point fresh grapefruit juice also gets added in. Since I had squeezed the grapefruit on just a table top glass juicer (you know the old fashioned, traditional kind) there were bits of pulp trapped in the 'teeth' of the juicer. So naturally I added all the bits of pulp I could to the juice, instead of straining it out. I wanted it for flecks of colour, and texture. This gets added to the custard mixture as well. At this point I put everything in the fridge to cool completely. And then it all went into the machine to do its work.
Diana suggests serving this ice cream with simple, plain cookies. Well, I never have these kinds of cookies in the house! Of course, a simple shortbread or sugar cookie would fit the bill. But we really don't eat cookies like that. So what could I serve with this ice cream? I decided to let the ice cream inspire me. I would create a cookie just for this occasion. I liked the idea of basil in the cookie. Of course I could do a basil infused shortbread. But I just didn't want to go there. Was there an easier way? I let my mind wander down all sorts of weird boulevards and lanes, and then it hit me. Puff Pastry. Good ole store bought puff pastry. There is always some in the freezer. I could create a twist of some sort. A sweet take on a cheese straw.
So I decided that instead of coating the pastry in cheese and herbs, I would use sugar, lemon and lime zest, and basil. I started by covering the counter in a layer of sugar. I laid out the sheet of puff pastry over it, and gently rolled over it, to push the sugar into the pastry. Then I sprinkled some more sugar as well as some of the zest and chopped basil on top of the pastry. A quick roll to push it into the pastry, and then I folded it in half. I covered the new top in a final layer of sugar, zest and basil and rolled it into a rough 8 x 10″ sheet. This I then cut into 10 strips, so that the 8″ made the length of the twists. These got twisted and placed on a parchment line baking sheet. Into the oven for 15-20 minutes till golden. When cooled enough, they got transferred to a cooling rack.
Being puff pastry, they are already tempting! Crunchy, puffy, golden. Then citrus zest and sugar gave them a lovely crisp coating. These cookies are perfect with the ice cream. The crunch and brightness of the cookie doesn't compete at all with the ice cream. Rather, it compliments it perfectly. I hope Diana would approve of the cookie that her ice cream inspired!
These cookies whip up so easily. Why not make a batch, switching up the flavours? Try orange and cinnamon instead of the basil and lime. Or how about some cardamom and finely ground pistachios? These would be great with tea or coffee!
Love Jen
Pink Grapefruit and Basil Ice Cream with Citrus Twists
A fresh summery ice cream that marries bright pink grapefruit with the faint sweetness of basil is already a joy to make up. Add a lemon lime and basil puff pastry twist, and you have the perfect crunch and contrast to accompany this dreamy summer dessert!
Ice Cream
- finely grated zest and juice from one large pink grapefruit
- 1/4 cup granulated sugar
- 1 1/4 cups whole milk
- 35 basil leaves
- 4 large egg yolks
- 1/3 superfine sugar
- 2/3 cup whipping cream
- 1 to 2 tbsp lemon juice
Citrus Twists
- 1 sheet of puff pastry thawed
- 1/2 cup granulated sugar
- zest from 1 lemon and 2 limes
- 2 tsp finely chopped basil leaves
Ice Cream
Put the grapefruit zest and granulated sugar into a mortar and pound with the pestle.
Heat the milk with the pounded zest mixture until it reaches boiling point. Remove from the heat and coarsely tear the and add the basil leaves. Cover and set aside to infuse for a couple of hours.
Using a hand held electric mixer, beat the egg yolks with the superfine sugar until pale and thick.
Strain the flavoured milk into a glass measuring cup, using the back of the spoon to press out all the flavour from the basil leaves and the grapefruit zest. (I did add some of this pressed zest into the strained mixture)
Stir this into the beaten egg mixture and put it into a clean heavy bottom pot.
Over low heat, stirring all the time, heat the custard until it thickens slightly. It needs to be thick enough to coat the back of a spoon, so that you can run a finger across it and it leaves a channel that doesn't come back together. Be really careful, as the eggs will scramble if it gets too hot.
Immediately pour this into a cool bowl (set the bowl into a larger bowl filled with cold water and ice cubes) Let the custard stand in this till it reaches room temperature, stirring occasionally as it cools.
While this is cooling, whip the cream into soft peaks, being careful not to overbeat it. Fold in the completely cooled custard, and then stir in the grapefruit juice that you had strained at the beginning (I use some of the grapefruit pulp in it as well, for texture and colour flecks)
Add 1 tbsp of the lemon juice. Taste, it should enhance the grapefruit flavour, not overwhelm it. Add another if necessary. This will depend on the grapefruit you are using. Some are more delicate that others. Depending on the grapefruit, the colour may also be affected, some grapefruits are much more coral, while others are a truly pale pink.
Here's a trick: if you find that your custard is too pale and you really want it to look more pink, why not take a one or two teaspoons of pomegranate molasses and mix it thoroughly with the lemon juice before adding the lemon to the mixture! It is tart, and that little bit won't really alter the flavour. But the pink will definitely be enhanced!
At this point I chilled the entire mixture in a bowl covered with cling film in the fridge for a couple of hours. Diana says it can go directly into the machine. I like it to be really cold before it hits the cold bowl of my machine. See Notes below for alternative method for churning.
Follow your machine's directions (mine took about 20 minutes to churn up) Transfer to a prepared container and put into the freezer to set completely.
When ready to serve, remove from the freezer about 10 minutes early to soften it for easy serving.
Citrus Twists
Prepare a baking sheet with parchment paper. Preheat the oven to 375F.
Spread out 1/4 of the sugar over your counter roughly the same size as the thawed puff pastry sheet.
Lay the sheet over the sugar.
On top, sprinkle about 2 tbsp of sugar, along with half of the lemon and lime zest, and half of the chopped basil, spreading it out evenly over everything.
Roll this out gently, just to push the sugar and citrus zest into the dough. This will keep if from falling off when baking.
Fold in half. You want to be able to roll this final folded sheet into an 8 x 10" sheet, so fold accordingly.
Sprinkle the new top with a bit more sugar (I just used all the bits of sugar that were scatter on the counter around the pastry (it should make up about another tbsp or two) Sprinkle the final zest and basil over everything as well.
One final roll to get it to the correct dimensions. So now you have a sheet about 8" high, by 10" wide. Cut this sheet into 10 1inch strips.
Picking up one strip at a time, transfer it to the sheet, twisting it several time before laying it down on the parchment. If the strips want to open up, just push the ends down lightly.
Place the twists about 1inch apart, or as wide apart as possible for your baking sheet.
Bake on the middle rack until golden brown, the sugar starting to caramelize in spots. This should take anywhere from 20 minutes or so. Just watch- they should have puffed and firmed up, become crisp and just golden. They will still be soft when ready to come out, but they will continue to firm up. Start checking at the 15 minute mark.
Take the baking sheet out and let the twists rest till cooled down enough to touch. Transfer to a cooling rack where they will continue to firm up a bit.
Best eaten the day they are made, but these can be reheated in a toaster oven for a few minutes at 300F.


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The staggering figure comes in the wake of Gordon Brown's refusal to hold a referendum on the hated Lisbon Treaty - despite promising to at the last general election.
UK Independence Party Leader Nigel Farage said..."Over the last few years we have seen how the EU are prepared to bypass the democratic will of the people by ignoring the results of referendums.
"Our own government was so scared of the result here that they refused to allow us to have a say on our future."It's clear that if we want to remain a sovereign nation then the only way is out: It's time we governed ourselves again."
One MyExpress member said:
In 1973 we joined the EEC to TRADE only
Read more: 95% SAY QUIT THE EU


text:
This year, 24th September The Arthur's Day 2010 celebrated in a big way, not only through music but as well as food. As at Souled Out, Jarrod & Rawlins, Royak Oak and as well as Finnegan's, delectable Guinness infused dishes were showcased. As the celebration was gearing for the countdown I was invited to sampled such creation at Souled Out in Sri Hartamas. What makes the night so special, the The Arthur's Bus was there too and I got to have a tour in it.
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PEMBERTON, N.J. (WPVI) --A fast-moving fire forced residents out of their apartments in Pemberton, New Jersey.
The blaze started after midnight Monday at the Pine Meadow apartment complex on the 100 block of West Hampton Street.
"My girlfriend was asleep, I just hear sirens. I look out the window, I just see flames everywhere," resident Ira Jackson said.
"People were screaming and I came out on the balcony, you can could the flames just shooting up and the wind was blowing," resident Doris Kennedy said.
Everyone in the complex was able to make it out safe.
The damage spread into the nearby units.
The apartment engulfed in flames was unoccupied.
However, eight families totaling 25 people are temporarily homeless.
In one of the units near where the fire started the roof is caved in and debris has fallen all around the kitchen. Next-door, in one of the children's rooms, the roof caved in as well with debris falling all over the toys and clothes.
Neighbors say Pine Meadow management has been very cooperative.
A restoration company was on the scene to begin the rebuilding process.
Action News is told management has put some residents in other apartments for now.
Those we spoke with say they can wait for repairs, they're just happy no one was hurt.
"It was pretty wild. They got on top and with hatchets they were breaking in, trying to control fire. It was just amazing and scary," Kennedy said.
The Red Cross is assisting the 25 people displaced by the fire.


text:
- Instant Download: No Waiting!
Dropped the mixtape; shit sounded like an album! Hope evreyone enjoys! This is raw South Jersey Hip-Hop with a twist of self inspired samples we grew up listening to. It took us about a year to put this together. Take a listen!! Thank you all for the love and support!! Stay Gold!! for more songs and beats from us check out our soundcloud, youtube, and Facebook pages also follow us on twitter!! https://soundcloud.com/staygoldproductions29 https://soundcloud.com/arule https://soundcloud.com/juhkel https://soundcloud.com/staygoldbeats http://www.youtube.com/StayGold29 http://www.youtube.com/Arule46 https://www.facebook.com/StayGoldSGB https://twitter.com/TheKidPay email @TheKidPay for any bookings or beats @ email@example.com
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text:
Alternative Titles
Synonyms: Nocturne of a Certain Pilot
Japanese: とある飛空士への夜想曲
Type: Novel
Volumes: 2
Chapters: 6
Status: Finished
Published: Jul 20, 2011 to Sep 17, 2011
Authors: Inumura, Koroku (Story), Morisawa, Haruyuki (Art)
Serialization: None
Score: 8.001 (scored by 13 users)
1 This score is not weighted. Please note that 'Not yet published' titles are excluded.
Ranked: #200352
2 based on the top manga page. Please note that 'R18+' titles are excluded.
Popularity: #20329
Members: 182
Favorites: 3


text:
Fixed Precision Arithmetic http://github.com/ekmett/fixed-precision
|Latest on Hackage:
This package is not currently in any snapshots. If you're interested in using it, we recommend adding it to Stackage Nightly. Doing so will make builds more reliable, and allow stackage.org to host generated Haddocks.
Numeric instances for MPFR that use the "Implicit Configurations" from
to choose a
Rounding and
Precision. For those that do not want to
use reflection, explicit instances are provided for common precisions
and for the built-in rounding modes.
sin pi :: Fixed Down Double
fixed Near 256 (sin pi)
Depends on 6 packages:
Used by 1 package:


text:
Special Olympics Iowa is holding its annual State Equestrian Competition at the Jester Park Equestrian Center in Granger on Saturday, September 7. "We are expecting 66 athletes from across Iowa to participate in this event," said Special Olympics Iowa Vice President of Program, Pam Wagner. "It is an exciting day for the athletes and gives them the chance to display their skills and showmanship in various activities throughout the day."
Wagner noted she is especially pleased to have student volunteers from Ellsworth Community College in Iowa Falls returning again this year to help make the event a success. "Many of the student volunteers have grown up with horses and have the expertise to help with the event," she said. "We also encourage the public to attend and cheer for the athletes."
Special Olympics Iowa (SOIA), a statewide nonprofit organization, provides high-quality training and competition for children and adults with intellectual disabilities in all 99 counties of Iowa. SOIA offers 23 Olympic-style sports to nearly 11,000 athletes and Unified Sports partners year-round. Since 1968, Special Olympics has provided an inclusive culture that stresses athletic excellence, rewards determination, emphasizes health, and celebrates personal achievement.


text: I recently had the privilege of contributing some coloring pages (depicting the life of Christ) to the school cirriculum of Heroic Life Discipleship. Above are a handful of them (the last coloring page can be downloaded here as part of a sample PDF of the cirriculum, page 19). HLD is a great organization with an incredible vision. Be sure to check them out!


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Chevrolet Corvette Vintage Racing Car
While the first series cars of 1953 to 1955 introduced the new Corvette to America, the second series, with its clean good looks and V8 power quickly outsold the older style by a wide margin. With the advent of the 283 cubic inch version of Chevrolet's lightweight and durable small-block engine in 1957, the Corvette truly fulfilled its promise as a true American sports car.
A few years after it rolled off the St. Louis production line, the Corvette offered here was modified for drag racing and campaigned in the Oakland Bay area into the 1980s. It was then purchased by Randy Peterson and converted for road racing, and used as such by Tom Armstrong and Jack Goeffette between 1992 and 1998. Art Redford of Gig Harbor, Washington then purchased the car, and it has been maintained and improved by Tony Garmey at Horizon Racing ever since. The old warrior has received many improvements over the years, including expert modification of the Rochester fuel injection system by Chris Wickersham, while Roy Paola ported the vintage "fuelie" cylinder heads. In addition, the Corvette is equipped with a set of 1957-vintage heavy-duty brakes with vented backing plates, "elephant ears", and finned drums.
The Corvette has competed in over 100 races over the last two decades, and it currently holds lap records at Portland International Raceway, Sears Point, and Laguna Seca. Meanwhile, in Vintage Big Bore competition, the Corvette has won the 2007 "Wine Country Classic" at Sears Point, as well as the 2007 Monterey Historics at Laguna Seca. Today, the victorious Corvette displays a white racing livery accented by a smart blue racing stripe, as well as a roll bar, a cut-down racing windscreen, and period-style American Racing Torq-Thrust wheels. In addition, the car is offered complete with two logbooks, as well as its original seats and steering wheel.
This car was auctioned off by RM Auctions in January of 2009 at the Arizona Biltmore Resort & Spa, Phoenix, Arizona.
310hp (at rear wheels), 283 cu. in. V8 engine, Rochester mechanical fuel injection, GM Muncie four-speed manual transmission, independent front suspension with unequal-length A-arms, coil springs and anti-roll bar, live rear axle with semi-elliptic leaf springs and anti-roll bar, and four-wheel ventilated hydraulic drum brakes with finned drums. Wheelbase: 102"
Source: RM Auctions
Photo Credit: Copyright Bob Pengraph


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Lake Buena Vista, FL 32830407-939-BASS (2277)Visit Website
Guided catch-and-release outings let you experience bass fishing at its finest—all year round! Whether you're a seasoned sportsman or an amateur angler, a guided fishing excursion is fun for Guests of all ages. Choose from Guided Bass Fishing Excursions, which includes a 21-foot Sun Tracker pontoon boat that can accommodate up to 5 Guests, and a tournament-style NITRO® bass fishing boat for one or 2 people. Both 2-hour and 4-hour excursions are offered, and if available, an extra hour may be added in person at the Marina. Solo anglers may book an afternoon excursion at a reduced rate. Reservations can be made up to 180 days in advance.


text:
A Case For Hope BTC
In the short term i think we will see a bounce to 10500. Every time the RSI has broke 30% as i circled, it has shot up to at least 60%. As we just broke it, i think we are going to see a nice big bounce. If the bounce continues for one or two more candles we should see the MACD cross, which would point bulling. I am bullish in the next two days but bearish long term.


text:
CINCINNATI — The Ravens boarded their plane with commemorative championship caps and headed for the only place they want to be at this time of the year.
Homeward bound. And very happy.
Baltimore clinched the AFC North title with a 24-16 victory over Cincinnati on Sunday, completing a perfect run through one of the NFL's toughest divisions. The Ravens finished tied with Pittsburgh at 12-4 but had the tiebreaker with their two head-to-head wins.
The Bengals made it, too, getting every bit of help they needed right up to the end. Cincinnati (9-7) didn't beat a playoff-caliber team all season, going 0-7, but advanced to the postseason when the Jets and the Broncos also lost on Sunday.
Baltimore hadn't won the division since 2006, making the playoffs the last three years as a wild card and coming up short of the Super Bowl. The Ravens made it an overriding goal to get home-field advantage this time around. Their win on Sunday left them with the conference's No. 2 seed and a first-round bye followed by a game at home, where they are 8-0.
"Especially in the way we did it, to go undefeated in a division that has three playoffs teams is a pretty big accomplishment," said Joe Flacco, who was 15 of 19 for 130 yards with a touchdown.
Ray Rice had touchdown runs of 70 and 51 yards, and Baltimore's defense finished it off by knocking down Andy Dalton's desperation pass into the end zone as the clock ran out. Ravens players raised their helmets in celebration, ran off the field and donned championship shirts and caps.
"This is a great achievement, especially when you consider whatever doubters we had," linebacker Ray Lewis said. "We swept our whole division. Now the world comes to Baltimore."
The Bengals learned during the final seconds that they had secured their third playoff berth in the last 21 years despite the loss.
No hats or shirts for the Bengals, though. They exchanged congratulatory hand slaps with a few fans as they left the field, and that was it for the celebration.
"It's kind of weird," said Dalton, who was 22 of 44 for 232 yards with no interceptions or touchdowns. "Obviously we didn't get it done today, but we still have a chance."
Cincinnati will play next Saturday at Houston, which clinched the AFC South title by beating the Bengals 20-19 at Paul Brown Stadium on Dec. 11. Dalton is 3-0 at Reliant Stadium, where he played two games in high school and one at TCU.
With Paul Brown packed to capacity with Bengals fans for the first time all season, Rice made the biggest plays on a blustery afternoon that made it tough to throw. He had a career-best 70-yard touchdown run on the fourth play.
Rice also broke a 51-yard touchdown run on a third-and-1 play with 5:41 to go, essentially finishing Cincinnati's chances of yet another big comeback. Rice finished with 191 yards on 24 carries and set a club record with his 15th touchdown of the season.
"To be able to win the division on the road to secure a home playoff game, the feeling in that locker room was like no other," Rice said.
Baltimore's defense had a hand in it, too. Linebacker Terrell Suggs hit tight end Jermaine Gresham after a catch, jarring the ball loose. Three plays later, Rice went 51 yards to put the Ravens on the verge of a title.
Suggs sacked Dalton, forcing the Bengals to settle for a field goal on their next possession. Cincinnati got the ball back at its 20 with 1:05 to go and no timeouts left, but came up short on Dalton's final pass into the end zone.
"This feels good," Suggs said. "You just have to take it in."
During that final, futile drive, the Broncos' score was shown on the videoboard, drawing a loud cheer from the crowd of 63,439. Some of the Bengals saw it, too. Others didn't know what had happened.
"I heard the crowd and I asked somebody, 'Was there a penalty on that play?'" cornerback Nate Clements said. "He said, 'Denver lost. We're in.' I still wasn't sure. Then we came into the locker room and they confirmed it."
The Bengals stayed in playoff contention by pulling off comebacks, overcoming double-digit deficits in the second half three times. They put themselves in position for another one when Bernard Scott broke a 25-yard touchdown run late in the third quarter. Mike Nugent's 46-yard field goal cut it to 17-13 early in the fourth quarter, but Rice put it away.
Notes: The Ravens also won the division in 2003 and 2006. ... Rice joined Hall of Famer Marshall Faulk as the only players with 1,000 yards rushing and 700 receiving in more than one season. ... Suggs has a career-high 14 sacks, one shy of Peter Boulware's club record from 2001. ... Ricky Williams carried six times for 28 yards and became the 26th player in NFL history to run for 10,000 yards in his career. ... K Billy Cundiff was back after missing one game with a sore left calf. He made a 42-yard field goal into the wind. ... It's the third time in the last four years that an AFC North team went 6-0 in the division — Pittsburgh did it in 2008 and Cincinnati in 2009. ... Bengals K Mike Nugent made three field goals, giving him a team-record 33 for the season. ... The Bengals haven't won a playoff game since 1990.


text:
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text:
Seville fell in a short time at the beginning in the Spanish Civil War in 1936. Typical Queipo de Llano performed a coup within the city, swiftly capturing the city centre.[29] Radio Seville opposed the uprising and identified as for the peasants to come back to the town for arms, whilst staff' teams established barricades.
Seville is found not several miles inland from your Andalusian coast, but nevertheless sees a much more continental weather than the closest port metropolitan areas Cádiz and Huelva one example is??although it is far way too gentle in Winter season to get referred to as a 'appropriate' continental area. It is in a relative length in the three larger sized metropolitan areas while in the region, as well as Lisbon in Portugal, rendering it undoubtedly the largest town inside the south from the Iberian peninsula.|The nineteen nineties observed large progress in financial commitment in infrastructure in Seville, mostly because of its web hosting on the Universal Exposition of Seville in 1992.|At present, people today from all around the planet Reside facet by side Using the regional men and women in Cebu. Though practically every single religion is practiced in some sort, Roman Catholicism is the most crucial faith. For lots of the mountain villagers, the pre-Spanish tradition continues to be their technique for lifetime.|Usually, Females dress in elaborate flamenco dresses and men dress within their best suits. The marquees are set up with a long-lasting fairground during the district of Los Remedios,[55] through which Every Avenue is named following a well-known bullfighter.|Helps brake the auto when it senses an usually unavoidable collision by using a vehicle detected before you.*|Our employment laws assist retain workplaces truthful. Know your tasks and also your staff legal rights.|To apply for a person of such visas, you?�ll initially need to build an account. Once you?�ve done this, it is possible to then login and apply. You may as well use your login to examine your software standing.|- CEDEI helps academics of their look for lodging in Cuenca. - Wellness coverage for instructors under CEDEI?�s sponsored volunteer visa - fifty% return on the cost of the visa ($250 visa whole Price) - Discounts at unique locations in city|If both of these positions are of sturdy fascination to you please send out your CV to the email handle specified on The task heading.|Login in this article to use on the net on your Work visa. For those who have not obtained an account, it is possible to make a single below.|?�分享國?�外?�活體驗,個人?�受?�供?��?-----------------------------------------------------------------------------??We are trying to find enthusiastic, competent teachers to affix our awesome staff for a year. We offer an structured, beneficial function natural environment, in addition to lots of assist for our academics.|To submit an expression of desire, you?�ll very first require to create an account. As you?�ve accomplished this, you can then login and post an EOI. You may as well use your login to examine the status within your EOI.|??College graduation diploma, with TEFL/TESOL certification (or the most up-to-date enrollment registration while in the degree or application)|For anyone who is a latest visa holder and provide your specifics to a 3rd-celebration (for instance a bank), they could use this information to confirm your visa utilizing the Visa Verification Service. Remember to look at this details before you decide to login.|The payment prepare consists of housing inside the Estelar residence, all utilities and wifi, a wage, health coverage, holiday vacation pay out, help in acquiring a function visa, and also a bonus spend in December and at the end of the Trainer?�s time with us. We also offer reductions on Spanish classes and courses, and we Arrange excursions for discounted selling prices.|Purchaser reminder: Please continue to keep your individual information safe; also remain vigilant to suspicious mobile phone calls or voice messages purportedly from Manulife, and also any faux e-mail, SMS, pop-up and any connection to an unknown third-party Internet site. If in doubt, make sure you get in touch with our Customer support Hotline at 2108 1188.|* Prolonged Method Transport more time objects for example ladders or surfboards by folding down the passenger-aspect seats in both of those the rear and entrance.* Tall Method Take out the headrests and fold up the back seats to produce as much as four ft of vertical Place for taller cargo merchandise.* Refresh Manner The entrance seats fold back again along with the rear seats recline for when all you must slot in can be a nap.*| The program operates from inside a college so we check with you to be conscious of this, and also remaining mindful of your respective friends and to respect The truth that you're a customer Out of the country.|TEFL Recruits is usually a recruitment enterprise put in place and operate by previous ESL teachers and managers. We know the categories of Employment that TEFL capable lecturers want with salaries that they deserve. Our partnered colleges have all been confirmed or checked by foreign teachers that have worked there to be sure pay is provided on time and contracts are adopted.|Cebu is a singular and fascinating location. Its shut proximity to other exotic vacationer Locations, minimal earth quake and typhoon action and wide range of geological miracles are combined with a fascinating assortment of plant and animal species.|Make a deposit payment to protected your home with a course ahead of the conclude in the month and qualify for any free of charge Superior level on the internet study course. You are able to Select from the fifty-hour young learners (CTEYL) or enterprise English (CTBE) certification courses or maybe the 250-hour on-line diploma study course.|In 1519, Ferdinand Magellan departed from Seville for the 1st circumnavigation on the Earth. Coinciding with the Baroque duration of European record, the 17th century in Seville represented essentially the most good flowering of the city's lifestyle; then started a gradual economic and demographic drop as silting while in the Guadalquivir forced the trade monopoly to relocate to the close by port of Cádiz.|馬尼?�、大?�台?�克?�克?�蘇比克?�打?�、碧?�、�??�、巴科羅?�怡朗?�大?�、長?�島?�巴?�望?�幾?�地?�你了解?�?}
This contemporary architecture construction homes the central market and an underground archaeological elaborate. The terrace roof is often a city viewpoint.[forty five] spots??together the route, which the Mines and Geosciences Bureau attributed on the fragility from the rock foundation, the abandoned mining operations near the highway and also the pure ground fractures which were undetectable in the 1900s. |Should you be a existing visa holder and supply your specifics to a 3rd-celebration (for instance a bank), they will use this information to validate your visa utilizing the Visa Verification Service. Make sure you read through this info prior to deciding to login.|Instructors teach no less than four lessons and can ask for additional classes and/or tutorials, if out there. Foundation CEDEI can be a non-gain Business and when teachers don?�t generate some huge cash by international criteria, they do generate plenty of to live comfortably in Ecuador and get A lot in instructing experience and cultural Trade.|In the event your automobile commences to stray from the center of a detected lane without signaling, the steering adjusts to aid provide you again towards the lane Centre.*|??Conducts actions to the campers for instance crew and unique sports activities, arts & crafts, doing arts, among the Other people|The biggest mosque in the region is Masjid Al-Maarif, which happens to be a identified centre of Islamic reports during the Philippines. The city also has smaller sized figures of Buddhists and atheists, in conjunction with users of other faiths.|TEFL International gives the realm?�s most highly regarded and perfectly-acknowledged TEFL teaching certificate. On completion in the system, we?�ll give you the option to assist you to find a educating task in Cebu, the Philippines or just about anyplace else you?�d like to work.|The writer Miguel de Cervantes lived largely in Seville in between 1596 and 1600. Since of economic challenges, Cervantes labored as a purveyor for that Spanish Armada, and afterwards being a tax collector. In 1597, discrepancies in his accounts of the 3 decades earlier landed him during the Royal Jail of Seville for a short time.|?�去?�律賓之?�,常遇?��??�人?�說,為什麼要?�菲律賓讀?�文?基?�上一定是好處比較多,?�以才?�人?��??�去?�,但你?�想?�,一?�月?�三?�五-五萬,差不多請個不??��?�文?�師了,如果你看?�還?�的?�想??��??��?�在?�灣補習?�,?�你?��?求可?�沒?�麼強。哈??Bitter Seville oranges increase on trees lining town streets. Previously, substantial quantities have been gathered and exported to Britain for use in marmalade.[citation needed] Today the fruit is utilized predominantly as compost regionally, as an alternative to to be a foodstuff.|Login here to apply online to your Scholar visa. If you haven't received an account, you may create one particular right here.|The city's enhancement ongoing following the Castilian conquest in 1248. Public properties ended up built together with churches, lots of which were built in the Mudéjar fashion, plus the Seville Cathedral, built through the fifteenth century with Gothic architecture.|Cambridge Test courses comply with a selected syllabus each morning as an alternative to the General 20 programme.|Our academics take pleasure in regular Expert advancement periods that happen to be precisely targeted to aid them improve the educating and Finding out practical experience.|Seville is easily the most populated city in southern Spain, and has the largest GDP (gross domestic product) of any in Andalusia,[63] accounting for one particular quarter of its overall GDP.[sixty three] All municipalities inside the metropolitan place rely right check here or indirectly on Seville's economic system, when agriculture dominates the economic climate in the scaled-down villages, with a few industrial action localised in industrial parks. The Diputacion de Sevilla (Deputation of Seville), with provincial headquarters from the Antiguo Cuartel de Caballería (Aged Cavalry Barracks) on Avenida Menendez Pelayo, provides public companies to distant villages which they can not present themselves.|Our Cebu system centre is considered the sole intense TESOL centre in the Philippines. We've been recognized from the Specialized Education and learning and Techniques Enhancement Authority (TESDA) so our specifications are continuously superior. This Philippine authorities agency screens all credible education centres from the country. Our higher expectations and frequent monitoring make certain a terrific romance with taking part faculties and excellent job prospects, both locally and internationally. Cebu is surely an island that spreads in excess of 5,000 get more info square kilometers and is particularly dwelling for three.|Information and facts : By sharing the written content of your web site on the above mentioned System, your site gets to be Portion of social websites and you'll push more visitors to your web site. / Whois Information and facts}
We satisfaction ourselves being a heat family atmosphere fostering content staff members that should instill integrity along with a lifelong really like of check here Finding out by English instruction and setting an excellent case in point by private perform. We inject entertaining, prospects, and Pleasure into the life of our college students as well as their family members by means of genuinely heat and caring support.
Training course deposits need to be compensated to our administrative Centre. Credit/debit card payments will be the speediest and most economical solution to pay, but we also take payments get more info by way of Western Union, Shell out Pal and financial institution transfer.
??Beautiful payment: You will get payment in you deal hrs even though you do not have lessons. the most well-liked bargaining locations incorporate Baguio Market place and Maharlika Livelihood Centre.|The American Backyard, also accomplished for Expo '92, is in La Cartuja. It's really a public botanical yard, using a agent collection of American crops donated by various international locations on the celebration of the planet exposition. In spite of its extraordinary botanical value, it remains a primarily abandoned put.|two Layering the creamy cashew sauce into The underside on the jar makes certain that your major, bold electrical power salad will not grow to be wilted by the time you happen to be ready to consume.|LSI instructors possess reliable training competencies and all employees are already carefully chosen to guarantee a welcoming and helpful company can be extended to all LSI learners. They may be on hand to information you through your research.|^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac "twenty sister metropolitan areas pledge to fortify ties with Baguio". Baguio Midland Courier. |Yet another critical supply of money for Baguio is its posture as the industrial hub to the province of Benguet. Most of the agricultural and mining items developed in Benguet go through Baguio for processing, sale or even more distribution to the "lowlands."|Baguio was founded like a hill station by the Individuals in 1900 at the site of the Ibaloi village often known as Kafagway. It absolutely was the United States' only hill station in Asia.[six] The name of town is derived from bagiw, the Ibaloi phrase for "moss".|Not extended ahead of the opening, the Spanish government began a modernisation of town in an effort to put together with the expected crowds by erecting new accommodations and widening the mediaeval streets to allow for your movement of automobiles.[28]|Since its establishment in 2002, UUNZ has emerged to be certainly one of Auckland's major personal establishments and has occasional options for TEFL trained instructors.|To submit an expression of curiosity, you?�ll initial have to have to develop an account. Once you?�ve carried out this, you'll be able to then login and post an EOI. You can even make use of your login to examine the standing of your respective EOI.|管理?�格?��??�比如會?��?禁限?�、規定放?�才?�外?�、�??�點?�、平?�會?�小?�、�?律遵守規定、程序該?�麼走就?�麼?�、比較不?�變?�等等,|Cuenca, Ecuador is found superior in a valley in Ecuador's southern Andes. Cuenca can be a town of in excess of five hundred,000 men and women and it is the third most significant metropolis within the country.}
Login here to use on-line in your Perform visa. In the event you haven't obtained an account, you'll be able to create just one here.
Therefore, you will not be finding your 1st paycheck for at least six weeks right after setting up coaching??you are chargeable for all of your living fees till then??you are|you're|you might be|you happen to be|you will be|that you are} required to have about US£4K to get started on out in Japan|With Healthy, Each and every trim amount builds upon the 1 before it, supplying you with extra characteristics and upgrades when you go.|The Alcázar experiencing the cathedral was produced from the former Moorish Palace. Design was started off in 1181 and ongoing for over five hundred decades, largely from the Mudéjar type, but also inside the Renaissance style. The favored Television set present Game of Thrones has shot quite a few scenes at this area.|A five-line commuter rail assistance (Cercanías) joins town Together with the Metropolitan area. Seville is about the Crimson Ciudades AVE, a Web designed with Seville next to seventeen significant towns of Spain with significant-velocity rail.|Massive-scale Roman archaeological remains might be observed there and at the close by town of Carmona too.|Central locations With centrally Situated educational facilities in a number of the most attractive cities on the earth, LSI pupils have use of numerous types of social and cultural functions.|The output in the analysis centres in Sevillan universities Operating in tandem with city govt, and the various area engineering providers, have created Seville a leader among the Spanish metropolitan areas in technological analysis and improvement.|Citizens from all other international locations need to Make contact with their community consulate to obtain present-day journey regulations.*|This created Seville the top defended port to convey the riches within the Americas. A 'golden age of improvement' commenced in Seville, on account of its being the only real port awarded the royal monopoly for trade with the escalating Spanish colonies inside the Americas plus the influx of riches from them. Considering the fact that only sailing ships leaving from and returning towards the inland port of Seville could engage in trade Together with the Spanish Americas, retailers from Europe and other trade centres required to visit Seville to accumulate New Environment trade products. Town's population grew to over a hundred thousand persons.[18]|For those who show enthusiasm and dedication though working with us, and have the ability to prove your capabilities in educating, and also discover our perform environment satisfying, you could be offered a one particular-yr academic agreement upon completion with the summer application. As a result, this 8-7 days summer time faculty will serve as a probationary period.|(Strawberries and string beans??referred to as|known as|called|often called|generally known as} Baguio beans over the Philippines?�are shipped to major city marketplaces through the archipelago.)|第�?,�?費當?�比一些歐美國家來得便宜,?�且?�活費也絕對比歐美國家的來得低,?�格來說?�菲律賓?�消費跟?�灣??��不多?��?Miguel and Tulio are con artists that stow absent over a ship sure for The brand new Earth and acquire a map for your fabled misplaced city of gold, El Dorado, and are invariably witnessed as gods because of the locals.|"Like" us to connect with other college students, look at videos, see work offers and in many cases get special discounts.|The tapas scene is among the primary cultural sights of town: men and women go from 1 bar to another, experiencing compact dishes termed tapas (basically "lids" or "addresses" in Spanish, referring to their possible origin as snacks served on compact plates accustomed to go over drinks).|?�以我建�?,如?�你??��?�在不知如何?�捨學校?�話,換?�角�?��?��??�入????an off-the-cuff reduction educating posture for an ESOL Trainer experienced to teach English language at pre to higher Intermediate Stage|Educating hours may very well be scheduled at any time among 7.30am and five.30pm, Monday to Friday, plus the ST won't be scheduled to work on Saturday or Sunday Unless of course Unique marketing occasions applicable to This system are planned.|During the TEFL study course in Cebu, it is possible to appreciate some of the earth?�s greatest scuba diving or snorkeling, consider during the delightful and inexpensive food, and in many cases engage in lively festivals.|??If you want to|If you wish to|In order to|If you'd like to|If you need to|If you would like} go to a pleasant school, head over to LSI. The employees and learners are pleasant and the variety of...??Duties: somewhere around 20 contact hrs each week with options for additional tutoring and dialogue classes (generally 4 courses assigned for every cycle). Most courses are Monday-Saturday.|Keep the keys as part of your pocket or purse then start out your In good shape Along with the press of a button. Honda LaneWatch??Information : Web site Speed is the velocity at which your site responds to instructions input. It is a lot more critical and advantageous for your web site to own this at a lessen price. It?�s crucial that you Focus on trying to keep this pace worth as minimal as is possible.|Prior to the existence of wetlands regulation inside the Guadalquivir basin, Seville experienced standard large flooding; Maybe worst of all were being the floods that happened in November 1961 when the River Tamarguillo, a tributary of your Guadalquivir, overflowed because of a prodigious downpour of rain, and Seville was Therefore declared a disaster zone.[34]|These positions are to show solely Kids up to the age of fifteen, and we are trying to find candidates While using the aptitude and need to prosper in this sort of environment employing their TEFL skills. Gains:|VisaView allows education suppliers to check the main points of the pupil's existing visa. Perspective our in depth guides for VisaView.|?�為氣候還?�就??��?�比較大,比較�??�。怎會?�樣說呢?因?��??�的訊息太主觀?�,但氣?�和?�型大�?說的?��?樣�?笑,?�不??���?|VisaView will allow training suppliers to examine the details of the scholar's recent visa. Check out our comprehensive guides for VisaView.}
Top quality inspected homestays Contact with other learners and native individuals helps make certain you practise these techniques outdoors the classroom.
Wherever is the following step�?* ?�網?��??�載之內容資?�僅供參?�用,�??��?確資?�均以領事館?�佈?�準??Also, through summer season, Specifically throughout Holy Week, tourists from all around the region flock to the city. During this time, the full amount of persons in town doubles.[35] To accommodate these men and women you will find much more than 80 hotels and inns readily available.[36] Neighborhood festivities including the Panagbenga Festival also appeals to the two area and international tourists.|At operate or in company, Kiwis Possess a 'can perform' check here Perspective and luxuriate in Functioning alongside one another to obtain the position completed. Your competencies and expertise could come up with a precious contribution in New Zealand.|汶萊 ?�埔�?�?�� ?�尼 ?�本 ?�撾 馬來西亞 馬爾代夫 緬甸 ?�朝�??��? ?�律�??�加???�國 ??��??�� ?�灣 泰國 越南|Analytic : Google, as well as becoming the worlds major internet search engine also supplies many other fantastic products and services. One particular of these delivered companies is Analytic. With a very small code additional to your site, Analytic means that you can monitor all user information on your site. Some of its free of charge products and services are: Actual time person info Person info generally speaking|Lecturers are going to be producing a favourable big difference during the lives of such college students with the outset. We are considered one of a limited amount of firms certified to operate within community schools in Hanoi and so, we are increasing fast.|大概就是來回機票?�機?�稅?�簽證費(?��?程多久影?�後續是??���??�生活費等,|Polvorones and mantecados are common Christmas solutions, whereas pestiños and torrijas are typically consumed in the course of the Holy Week.|?�根�??�利�?�� 巴�? ?�巴 ?�利 ?�瓜多爾 墨�???秘�? ?�拉??The Isabel II bridge, better referred to as the Triana bridge, dates from this era; street lighting was expanded within the municipality and most of the streets ended up paved during this time at the same time.[26]|If both events comply with the conditions from the agreement, The varsity sends a copy of the passport and also a letter in your closest Ethiopian Embassy (you may have to head to an embassy as part of your country of citizenship). Up coming, you can deliver your passport to the embassy and purchase the Performing visa.|??Generation of assessment sorts and tools for Kindergarten college students, beneath the guidance and standardisation of the BOM.|To post an expression of desire, you?�ll initial will need to create an account. After you?�ve accomplished this, you could then login and submit an EOI. You may also use your login to examine the standing of your respective EOI.|Little courses, exceptional academics Regular personal counselling and powerful class design make sure that you make quick development in critical interaction skills. Our lecturers are very carefully chosen, helpful, handy, and able to hear.|?�茨??�� ??���?馬達?�斯???�洛??納米比亞 ?�塞俄比�??�非 突尼西亞 ?�干??贊比�?津巴布韋|Our summertime camp, generally known as Kor Camp, offers thrilling work chances for English-indigenous and English-Talking counselors who would want to attain an enriching cultural and professional experience utilizing their TEFL expertise.|This training course can dietary supplement a Standard twenty or Intense Classes. Just one-to-A person The swiftest solution to improve your language skills is through individual lessons. Individual lessons are ideal if you prefer a very personalized target on your own aims. Notes}
Educational facilities Elite does outreach operate inside the Vietnamese public university program, dealing with young children who would not if not have use of excellent English language instruction.}


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I am CEO of Feemales Inc. A Brooklyn based online modeling company currently running an online all female calendar.
Feemales Inc has been around since 2008 – 4 years and its still growing.
With models like:
Angie Pontani (Miss Cyclone)
Helen Pontani (The Pontani Sisters)
Accidental Diva(Skittle Project)
Diablo Rosie(Double Shot At Love-MTV~Feemales Inc's first model)
2013 is going to be bigger and better. With our original Ladies and some new Ladies to make it HOTTER.
This means we are looking for some ladies to come join Feemales Inc. You think you're ready?
Then hit us up with your picture and a short Bio to:
email@example.com or firstname.lastname@example.com


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Your daily dose of style, interiors, food and life in Copenhagen - for you and your kids!!
Snowhite - or perhaps not so
17 comments:
OMG! SHE IS ADORABLE, that smile is incredible!ReplyDelete
Så cute!!! :-)ReplyDelete
great hairstyle ^_^!ReplyDelete
looks like a model
- Anonymous19 September 2012 at 10:13
lol, a tomboy princess :)ReplyDeleteReplies
She is a tomboy princess actually - perfectly said xxDelete
Snowhite has never looked this cheeky... or as cute.ReplyDelete
Such a lovely and funny child.
You're Blessed!
She is so adorable!ReplyDelete
A little princess!
Gosh, can I adopt her? Her cheeky personality so come through in your photos... I wonder where she gets it from???? xxReplyDeleteReplies
Hi hi - you noticed :)) She is a cheeky little monkey :)Delete
She makes a "perfect" Snow White. She has the most expressive eyes and one of the most sweetest and mischievous smiles I believe I have ever seen. I bet this one is a "live wire"! So cute!ReplyDeleteReplies
This one skips through life - and it is hard work keeping up with her - but then there is the face and that smile ;O)Delete
anya, your daughter is a doll! she looks so cute dressed up like snow white! so much personality and charm. i would bruise a lot as a child and now as an adult! hahahaReplyDelete
Me too - I bruise easily as well,Delete
Her face just brings out a huge smile :) She is soooo cute.ReplyDelete
Thanks for the comments - this was a lot of fun,ReplyDelete
She's too precious, love that. And my youngest has ants in her pants too, always climbing and falling, but at least she has fun. xoReplyDelete
These photos bring a huge smile to my face. Holly made a very adorable Snow White! Love her cheeky grin!ReplyDelete


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The single family homes are part of the gated Village Traditions community and blend the traditional elegance of Old Las Palmas architecture with high design interiors, resulting in a chic and stylish feel. There are three distinct two-story floor plans that boast of three spacious bedrooms and three baths.
The homes are designed to be private to neighbors, yet open and distinctively unique inside. The residences have been designed to embrace indoor-outdoor living, from the moment you enter the private courtyard entrance you are welcomed into tranquility.


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Benjamin "ProblemX" Simon won the Sonic Boom Capcom Pro Tour ranking event in Spain this weekend.
The Brit won playing as Birdie in the final against UAE's Adel "Big Bird" Anouche, who was playing as Ken.
ProblemX was playing under the Mousesports organisation during the Street Fighter V tournament.
A delighted ProblemX tweeted the following after winning:
I am so happy I won sonic boom, @FGC_Bigbird played amazing , I got the first European CPT thank you everyone and @mousesports TEAM BIRDIE#
— Benjamin (@MrProblemX) April 2, 2017
Eventhubs.com detailed the final and how it played out.
Here's the moment ProblemX clinched the victory:
You can see the full list of Capcom Pro Tour events here.