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Tag Archives: sedo
- Gambling .Com's Selling Well but No Longer Practical
October 19, 2011
Gambling related .com names are still selling well but with added threats from the DOJ, Gambling .com's are no longer practical.
- Trio of gambling-related domains for sale; Tea Party covets Canuck band's domain
September 21, 2011
Sedo to auction off three gambling-related domains: casino.net, poker.net and sports.net; Canadian rockers' domain attracts Tea Party
- Media Corp to auction off Gambling.com domain for acquisition cash
November 25, 2010
Media Corp has retained auctioneers Sedo to conduct the sale of the Gambling.com domain; Media Corp intends to use the proceeds for acquisitions.
Popular Posts
KAX Media rebrands as Gambling.com group
June 23, 2017


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Happy Thanksgiving, everyone! I have to admit, it was a little bit rough to wake up this morning and know that today was not going to involve the Macy's Thanksgiving Day Parade, a long run with my dad, copious amounts of food and drink with family and friends, or my family's signature out of control after dinner dance party. Luckily, though, I have a lifetime of American Thanksgivings ahead of me, and for all I know, this could be my last chance to give the holiday a Parisian spin. So, I made the day mine by pity-purchasing a festive-seeming necklace this morning that I will proceed to wear to the Thanksgiving dinner being held at my school this evening. Today may not include my dad's wine collection, my aunt's roasted winter vegetables, desserts from Gabriel's, or oysters freshly shucked by my grandfather, but I'll make it count. After all, I'm incredibly thankful to be here, and that's what the day's all about, right?
I just might be writing this from my History of Fashion class. (Don't worry, I'm listening out of the corner of my ear to our fascinating discussion on crinolines.) Once I get home, though, I have a new post to put up. Here's a preview:
When I was little, I would throw my dinner napkin over my head scarf-style (such a little lady), and, at the encouragement of my grandmother, proclaim through my giggles, "I'm a little Dutch girl!" (Sometimes I was Swedish, and with that shock of white-blonde hair, I certainly looked the part.) Anyway, I recently got to bring the childhood dream to life, and it was a delight. More to come!

subset: commoncrawl


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Sometimes people are perplexed when I tell them i'm not good at sports, my co-workers especially, "but you can run". Well trust me, there's a lot more to organized sports than running. Sure I can put on my tennis shoes and go lose myself in a run for a few hours, but throw a ball at me while doing so and we're talking about a whole different ball game (sorry that was lame). Not only am I not an athlete but i'm also not particularly knowledgeable when it comes to sports, sure I know the basic rules of pretty much all of them, but dont' ask me the specifics, names, statistics, records, etc. Nevertheless I love going to sporting events, I guess i'm more of a social fan than anything else. Some of my co-workers were surpsied when I told them I went to a baseball game, oh you like baseball, I think that's boring. Well yeah, the games can get boring, but I think of it more as something to do and time to spend with friends. So if you're looking for a play by play on the Samsung lions record, statistics or any particulars related to baseball you might want to go look for a new blog.
|Welcome to Lions Stadium
|Balloons and fireworks
|재원, 나, 된짱남자, 선미
|Double timing (hope that's not a hobby)
|Clearly 재원 didn't get enough baseball today
So there you have it, baseball in Korea, or I guess in Daegu anyway. I still have yet to make it to Busan for a game which I hear is a whole different ball park (haha I did it again), so i'll have to keep that on my Korean bucket list but until then Daegu will have to do. Even if you're not a baseball fan i'd suggest going to a game, if you have the right company, some snacks and a few drinks there's no way you could get bored. It's cheap, fun, entertaining and a bit comical, so go for it.


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23 January 2019
Global reach, higher impact
Materials and methods
Supplementary Material
International Journal of Biological Sciences
Journal of Bone and Joint Infection (JBJI)
Int J Med Sci 2014; 11(2):142-150. doi:10.7150/ijms.7142
Research Paper
Single Nucleotide Polymorphisms in the Metastasis-associated in Colon Cancer-1 Gene Predict the Recurrence of Hepatocellular Carcinoma after Transplantation
1. Key Lab of Multi-organ Transplantation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, P.R. China.
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Zheng Z, Gao S, Yang Z, Xie H, Zhang C, Lin B, Wu L, Zheng S, Zhou L. Single Nucleotide Polymorphisms in the Metastasis-associated in Colon Cancer-1 Gene Predict the Recurrence of Hepatocellular Carcinoma after Transplantation. Int J Med Sci 2014; 11(2):142-150. doi:10.7150/ijms.7142. Available from http://www.medsci.org/v11p0142.htm
Background: The newly identified metastasis-associated in colon cancer-1 (MACC1) gene is involved in angiogenesis, epithelial-to-mesenchymal transition (EMT), invasiveness, and metastasis in a variety of malignancies. Overexpression of MACC1 gene is a prognostic marker for poor outcome of hepatocellular carcinoma (HCC) patients. However, the association between genetic polymorphisms of MACC1 gene and poor outcome in HCC has been not been performed. We therefore investigated the correlation of MACC1 single nucleotide polymorphisms (SNPs) with tumor recurrence and overall survival in HCC patients undergoing liver transplantation (LT). Methods: The study included 187 HCC patients treated with LT. Five polymorphisms in the MACC1 gene (rs1990172, rs3735615, rs4721888, rs2241056, rs975263) were genotyped in 183 cases of tumorous tissue sample and 117 cases of adjacent normal tissue sample using SNaP-Shot assays. The association of SNPs with tumor recurrence and overall survival was then analyzed by additive, dominant, recessive, and overdominant models in a cohort of 156 HCC patients. Results: In terms of tumor recurrence, heterozygous of SNP rs1990172 and SNP rs975263 showed a significant high risk of relapse using univariate and multivariate analysis (overdominant, HR(95%CI)=2.27 [1.41-3.66], P=0.001; HR(95%CI)=2.16 [1.37-3.39], P=0.001). But the difference between heterozygous of these two SNPs and overall survival did not reach a significance in all models. The other three investigated SNPs were not significantly associated with tumor recurrence and overall survival (P>0.05). In addition, we found no significant difference in genotype frequencies between HCC and controls. Conclusions: Our data suggest that SNP rs1990172 and SNP rs975263 in the MACC1 gene may be potential genetic markers for HCC recurrence in LT patients.
Keywords: metastasis-associated in colon cancer-1, epithelial-to-mesenchymal transition
Primary hepatocellular carcinoma (HCC), which mainly constitutes 70% to 85% of liver cancer [1], is the six most common malignancy and the third most common cause of cancer related death worldwide [1,2]. However, most of the burdens are in developing countries, even half of these cases and deaths are estimated to occur in China [1]. HCC is one of the most devastating neoplasms worldwide with very poor prognosis. The recurrence rate after resection is approximately 50% at 2 years and 75% at 5 years [3]. Liver transplantation (LT) is a potential curative therapy for HCC patients [4]. However, recurrence is the main obstacle for the long term survival of LT patients [5]. For better clinical decision-making regarding therapy and better distribution of precious liver grafts, the stratification of outcome in HCC patients is mainly according to the clinicopathological characteristics, such as tumor size, tumor number, histopathologic grading, vascular invasion and preoperative serum alpha-fetoprotein (AFP)[6]. However, specific biomarkers for predicting recurrence and long term survival rates are still lacking.
Metastasis-associated in colon cancer-1 (MACC1) gene is located on chromosome 7 at position 7p21.1. The newly identified gene was initially discovered by genome-wide expression analysis in primary and metastatic colon cancer [7]. In this study, Stein et al showed that MACC1 expression in tumor specimens was an independent prognostic indicator of metastasis formation and metastasis-free survival [7]. Further study indicated that MACC1 was a key regulator of HGF-MET signaling pathway, whose function has been identified in tumor oncogenesis, invasion and metastasis [8,9]. Thus, MACC1 promoted proliferation, invasion and HGF-induced scattering of colon cancer cells in cell culture and tumor growth and metastasis [7]. Subsequently, MACC1 has also been identified in gastric cancer (GC) and contributed to a poor prognosis of GC by promoting tumor cell proliferation and invasion as well as the epithelial-to-mesenchymal transition (EMT) [10]. Moreover, the overexpression of MACC1 was also related to poor disease-free survival (DFS) in lung adenocarcinoma [11]. In pancreatic cancer, the overexpression of serum MACC1 may be a diagnostic marker and associate with tumor metastasis [12]. High expression of MACC1 was related to reduced relapse-free survival in rectal cancer [13]. In ovarian carcinoma, MACC1 also associated with metastasis of tumor cell and can be a target for antitumor therapy [14]. Furthermore, MACC1 was more frequently expressed in vascular invasive HCC [15] and associated with overall survival (OS) and DFS [16]. These findings suggested that MACC1 may play the prognostic role for a variety of malignancies.
In previous studies, genetic variation was significantly correlated with higher expression of MACC1, which could contribute to colorectal cancer (CRC) progression through mechanisms other than or additional to Met transcriptional upregulation [17]. Moreover, the relationship between the single nucleotide polymorphisms (SNP) of MACC1 and OS or metastasis-free survival (MFS) of CRC patients has been detected [18,19]. However, the effect of MACC1 SNPs on the clinical outcome of HCC has not been investigated yet.
In this study, we investigated whether tagSNPs of MACC1 were correlated with clinicopathological characteristics, recurrence and overall survival of HCC in patients treated with LT. Further, the relationship between the genotype of MACC1 and the risk to development of HCC was also examined.
Materials and methods
Patients and samples
The present study enrolled 187 HCC patients who underwent LT in our center from 2003 to 2012. The inclusion criteria were as follows: (a) HCC was diagnosed either before or following transplantation (as an incidental finding). The diagnoses were confirmed by two experienced pathologists; (b) all patients included in this study were Han Chinese; (c) clinicopathological variables, such as portal vein tumor thrombi (PVTT), preoperative α-fetoprotein (AFP) concentrations, age, tumor size, and gender were obtained before surgery and during follow-up; (d) absence of de novo HCC nodules in the transplanted liver. This study protocol was approved by the Ethical Review Committee of the First Affiliated Hospital, School of Medicine, Zhejiang University, and informed consent was obtained according to the Declaration of Helsinki. Among the 187 HCC patients, 183 cases had tumorous tissue sample, 117 cases had adjacent normal tissue sample. There were 113 matched-pairs among the 187 HCC patients. All the specimens from 187 patients were stored at -80°C before extracting genomic DNA. The study was conducted in blinded fashion so that all outcomes were unknown to investigators performing genotype.
Follow-up data were obtained after LT for 156 patients. The follow-up period was defined from the date of operation to the death or last follow up of the HCC patients. Tumor recurrence or metastasis was monitored by AFP, ultrasonography, chest X-ray, and emission computed tomography every 3 months for the first 2 years and semiannually thereafter. Recurrence was diagnosed by imaging techniques, either intrahepatically or extrahepatically. An increase of AFP without radiologic evidence of a new tumor was not diagnosed as recurrence till this became recognizable on imaging.
Genomic DNA was isolated from frozen tumor tissue and adjacent normal tissue using DNeasy Tissue Kit (Qiagen, Valencia, CA) according to the manufacturer's instructions. In this study, five tagSNPs were carefully selected in two ways: 1) by literature retrieval. 2) by analysis of HapMap genotyping data in Chinese (http://www.hapmap.org), with high frequencies[minor allelic frequency (MAF) >0.1] according to the method used by Carlson et al[20]. In this study, SNP of rs1990172 was successfully genotyped in 178 tumorous tissue samples and 114 adjacent normal tissue samples. SNP of rs975263 was successfully genotyped in 177 tumorous tissue samples and 117 adjacent normal tissue samples. SNP of rs3735615, rs4721888, rs2241056 were successfully genotyped in 183 tumorous tissue samples and 117 adjacent normal tissue samples, respectively. Genotyping of all selected SNPs were conducted using Applied Biosystems SNaP-Shot and TaqMan technology. To assess the reliability of genotyping, a random selection of >10% of samples were regenotyped with 100% concordance. PCR primers were listed in Supplementary Material: Table S1.
Statistical analysis
The allele and genotype frequencies between tumorous tissue groups and adjacent normal tissue groups as well as clinicopathological characteristics were tested using the Pearson χ2-test or Fisher exact test. RFS was defined from the date of transplantation to the time of first recurrence or the last follow-up assessment. OS was calculated from the date of transplantation to the death of patients or the last observation. Patients without recurrence at the time of last follow-up were treated as censored events. The relationship of MACC1 SNPs to RFS or OS was identified using Kaplan-Meier method and analyzed using log-rank test. Then, univariate Cox regression analysis was used in analyzing the association between the positive SNPs or clinicopathological characteristics and RFS or OS of HCC patients. Further, Cox's proportional hazard model were used for the multivariate analysis only when the variables were significant in the univariate analysis. Hazard ratios (HR) and 95% confidence intervals (95%CI) of the hazard ratios were derived from univariate and multivariate Cox proportional hazards models. All tests were two-tailed and a p<0.05 was considered statistically significant. Data analyses were performed using SPSS software (Version 20.0, SPSS Inc. Chicago, IL).
Patient characteristics
In present study, we have obtained 156 HCC patients clinicopathological and survival data among all the 187 included HCC patients. Among these 156 HCC patients, there were 143 male (91.7%) and 13 female (8.3%), respectively. There were 81 patients (51.9%) with age <50 years old and 75 patients (48.1%) with age >50 years old. The follow-up time ranged from 1.8 to 116.7 months. Over a mean follow up period of 37.0 months, 86 deaths (55.1%) were recorded. The patient clinicopathological characteristics were presented in Table 1.
Table 1
Patient characteristics with respect to recurrence and overall survival
Hazard ratios (HR), 95% confidence intervals (95% CI) and P value were obtained from univariate Cox regression analysis.
Analysis of SNP frequencies and HCC development as well as tumor recurrence and overall survival
Five SNPs in the MACC1 gene were genotyped in tumorous tissue samples and adjacent normal tissue samples of HCC patients with LT. The allele frequency and genotype frequency of each SNP was shown in Table 2. MAFs were similar to those given in HapMap SNP database for a CHB analysis panel and all five MACC1 SNP genotype frequencies were in Hardy-Weinberg equilibrium( P>0.05) (data not shown). The number of samples detected for each polymorphism was not exactly equal due to unsuccessful amplification of some samples. The difference of genotype or allele frequencies between tumorous tissue samples and adjacent normal tissue samples of HCC patients with LT was not statistically significant, indicating that these five SNPs were not involved in the susceptibility of HCC (Supplementary Material: Table S2).
Effect of investigated MACC1 SNPs on RFS and OS in HCC patients treated with LT was evaluated by univariate Cox regression analysis using an additive model of inheritance in accordance with the distributions of the five SNPs (Table 2). Among selected SNPs, rs1990172 and rs975263 were significantly associated with an increased risk for recurrence (P=0.001 & P=0.004, respectively). Meanwhile, the other three SNPs didn't show an obvious impact on tumor recurrence. However, the association between the SNPs of rs1990172 or rs975263 and overall survival in HCC patients treated with LT did not reach the significance (P=0.072 & P=0.087, respectively), which might be a result of the limited sample size. Remaining three SNPs showed no significant impact on overall survival, either (Table 2).
Table 2
Genotype and allele distributions in tumorous tissue and adjacent normal tissue of HCC patients treated by LT
aχ2 test. (Pearson χ2 test). bχ2 test. (Fisher's exact test). cLog-rank test.
Then, further assessment was performed by univariate and multivariate Cox regression analysis for the impact of SNP rs1990172 or SNP rs975263 on recurrence and overall survival in HCC patients treated with LT on the basis of an additive, dominant, recessive and overdominant model of inheritance, respectively. Results were shown in table 3. In the dominant model of inheritance, patients who have the genotype of GT or TT for SNP rs1990172 or patients who have the genotype of CT or CC for SNP rs975263 may confront a high risk of tumor recurrence. In the overdominant model, genotype of GT for SNP rs1990172 or genotype of CT for SNP rs975263 indicated a shorter recurrence-free survival time. Though, in the overdominant of inheritance, genotype of GT for SNP rs1990172 showed a significantly increased risk for reduced overall survival in univariate Cox regression analysis (P=0.028), but it did not reach a significance in multivariate Cox regression analysis (P=0.198). The results showed that in additive and recessive model of inheritance, there was no significance for the impact of investigated SNPs on tumor recurrence and overall survival of HCC patients treated with LT (Table 3). Further, in the multivariate Cox regression analysis, tumor size, preoperative AFP level, PVTT and SNP rs1990172 or rs975263 were four independent prognostic factor for recurrence in both dominant and overdominant model of inheritance (Table 4).
Moreover, Kaplan-Meier survival curves were presented in accordance with an additive, dominant, recessive and overdominant model of inheritance for SNP rs1990172 (Figure 1) and SNP rs975263 (Figure 2) on tumor recurrence of HCC patients treated with LT. From Figure 1, we can see that SNP rs1990172 obviously correlated with recurrence-free survival in a dominant and overdominant model of inheritance. The same conclusion can be drawn for SNP rs975263 from Figure 2.
Association between genetic polymorphisms and clinicopathological variables
To avoid a false association and demonstrate the relevant relationship of the recurrence and overall survival with polymorphisms, the associations of SNP rs1990172 and SNP rs975263 with clinicopathological characteristics were analyzed. There was no statistical significance between these two investigated SNPs and HCC patient age, gender, tumor size, preoperative AFP level, PVTT (Table 5).
Table 3
Impact of MACC1 SNP rs1990172 and rs975263 on recurrence and overall survival, shown for additive, dominant, recessive, and overdominant genetic models of inheritance
a Hazard ratios (HR) and 95% confidence intervals (95% CI) were obtained from univariate Cox regression analysis.
b Hazard ratios (HR) and 95% confidence intervals (95% CI) were obtained from multivariate Cox regression analysis.
Table 4
Multivariate Cox regression analysis of variables related to tumor recurrence at univariate analysis
AFP, α-fetoprotein; PVTT, portal vein tumor thrombi; HR, hazard ratio; CI, confidence interval.
Figure 1
Kaplan-Meier curve of MACC1 SNP rs1990172 on recurrence-free survival for HCC patients undergoing LT in an additive(A), dominant(B), recessive(C), and overdominant model(D) of inheritance, respectively. P-value was calculated by Log-rank test.(Click on the image to enlarge.)
Figure 2
Kaplan-Meier curve of MACC1 SNP rs975263 on recurrence-free survival for HCC patients undergoing LT in an additive(A), dominant(B), recessive(C), and overdominant model(D) of inheritance, respectively. P-value was calculated by Log-rank test.(Click on the image to enlarge.)
Table 5
Association of rs1990172 and rs975263 genotypes with clinicopathological variables.
aχ2 test. (Pearson χ2 test)
Metastasis-associated in colon cancer-1(MACC1) gene is a novel oncogene located on chromosome 7p21.1. In this study, we examined whether genetic variations of MACC1 gene had predictive value for recurrence and overall survival of HCC patients treated with LT. Notably, our results showed that polymorphisms of rs1990172 and rs975263 were significantly associated with tumor recurrence of HCC patients undergoing LT. As far as we know, this is the first investigation of MACC1 gene polymorphisms on the prognosis of HCC.
In previous studies, the prognostic role of MACC1 gene for tumor recurrence and overall survival in HCC patients has already been identified [16,21,22]. The predictive value of MACC1 overexpression has also been noticed in CRC [7,23], GC [10], lung carcinoma [11], pancreatic cancer [12]. Moreover, Galimi F et al [17] has demonstrated that Chromosome 7 polysomy and gain of the p-arm were significantly correlated with MACC1 overexpression leading to a poor prognosis of patients, which meant that genetic variation might affect the prognosis of patients through regulating the expression of MACC1 gene. As known to all that SNP is an important form of genetic variation, so whether SNP of MACC1 gene has an impact on the prognosis of malignancy needed to be further confirmed. Thus, Lang AH et al [18] has demonstrated that SNP rs1990172 can be a predictor for reduced overall survival in colorectal cancer patients. Moreover, Schmid F et al declared that CT genotype of SNP rs975263 might be associated with a reduced survival for younger colon cancer patients in early stages [19].
Actually, these two SNPs mentioned above were just the very significant SNPs covered in our analysis. SNP rs1990172 is situated in an intronic region of the MACC1 gene, which has no impact on coding exon of MACC1 gene. While SNP rs975263 is a nonsynonymous one with an exchange of leucine to serine at codon 515, fifth exon. In fact, these two SNPs are in strong linkage disequilibrium with each other (r2=0.858; http://www.hapmap.org). However, the substitution of leucine to serine at codon 515, fifth exon demonstrated no adverse effect on the structure or function of the MACC1 protein in silico analysis using software tools PolyPhen-2 and SIFT, respectively [18]. Moreover, the exchange of leucine to serine in the MACC1 gene was also demonstrated no impact on expression level of MACC1 mRNA in the CRC in vitro experiments [19]. Thus, further investigations need to be conducted to demonstrate the relationship between SNPs and poor prognosis of HCC patients.
In addition to evaluating the impact of SNPs within MACC1 on tumor recurrence and overall survival in HCC patients, we simultaneously evaluated potential correlation between MACC1 polymorphisms and HCC susceptibility. The results showed that there was no significant difference in the allele or genotype distribution of the polymorphisms in MACC1 gene between tumor tissue and adjacent normal tissue, which indicated that these five SNPs might not influence the risk of development of HCC. To our knowledge, no other studies on the impact of MACC1 polymorphisms on HCC development have been published.
It's worth mentioning that there were some inevitable limitations in present study. First, metastasis associated in colon cancer 1 (MACC1) gene, just as its name implies, is mainly correlated with the process of tumor metastasis. Thus, metastasis-free survival would be preferred as a more accurate endpoint. However, tumor recurrence and poor overall survival come hand in hand with tumor metastasis [24]. Thus, RFS and OS may also act as reasonable observation endpoints. Second, most of the included patients are unavoidably infected with hepatitis-B virus. Therefore, further studies are necessary to demonstrate the association between the polymorphisms and the prognosis of HCC patients caused by other diseases. Further, the sample size in our study is relative small. Further investigations are warranted to validate the prognostic role in large retrospective and prospective cohorts. Moreover, genomic DNA used in this study was extracted from liver tissue after LT. However, it is preferred to isolate genomic DNA from peripheral blood in our further studies, which is convenient and acceptable for the patients before operation.
In conclusion, this is the first study to demonstrate the correlation between polymorphisms of MACC1 gene and the prognosis of HCC patients undergoing LT. Our results suggest the potential role of MACC1 polymorphisms as a genetic marker for tumor recurrence in HCC patients treated with LT, which may help to stratify high risk HCC patients before LT. However, these findings need to be further confirmed through more large retrospective and prospective studies.
Supplementary Material
Table S1 - Table S2.
The authors gratefully acknowledge the study participants, the many surgeons and nurses who kindly facilitate the recruitment and collection of patient information. We also thank for the support of National Natural Science Foundation of China (No:81101840 & 81302074), National S&T Major Project (No.2012ZX10002-017), National Basic Research Program of China (973 Program) (No.2009CB522407) and Education Department of Zhejiang Province Research Project (No.Y201223762).
Competing Interests
The authors have declared that no competing interest exists.
1. Jemal A, Bray F, Center MM. et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90
2. Ferlay J, Shin HR, Bray F. et al. Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008. Int J Cancer. 2010;127:2893-917
3. Maluccio M, Covey A. Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA Cancer J Clin. 2012;62:394-9
4. Mazzaferro V, Regalia E, Doci R. et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693-9
5. Zimmerman MA, Ghobrial RM, Tong MJ. et al. Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicators. Arch Surg. 2008;143:182-8
6. Zheng SS, Xu X, Wu J. et al. Liver transplantation for hepatocellular carcinoma: Hangzhou experiences. Transplantation. 2008;85:1726-32
7. Stein U, Walther W, Arlt F. et al. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat Med. 2009;15:59-67
8. Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol. 2010;11:834-48
9. Gherardi E, Birchmeier W, Birchmeier C. et al. Targeting MET in cancer: rationale and progress. Nat Rev Cancer. 2012;12:89-103
10. Wang L, Wu Y, Lin L. et al. MACC1 upregulation predicts a poor prognosis of gastric cancer, and promotes tumor cell proliferation and invasion. Int J Cancer. 2013 [Epub ahead of print]
11. Shimokawa H, Uramoto H, Onitsuka T. et al. Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence. J Thorac Cardiovasc Surg. 2011;141:895-8
12. Wang G, Kang MX, Lu WJ. et al. MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance. Oncol Lett. 2012;4:783-791
13. Kawamura M, Saigusa S, Toiyama Y. et al. Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy. Anticancer Res. 2012;32:1527-31
14. Zhang R, Shi H, Chen Z. et al. Effects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cells. J Exp Clin Cancer Res. 2011;30:83
15. Shirahata A, Fan W, Sakuraba K. et al. MACC 1 as a marker for vascular invasive hepatocellular carcinoma. Anticancer Res. 2011;31:777-80
16. Qiu J, Huang P, Liu Q. et al. Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma. J Transl Med. 2011;9:166
17. Galimi F, Torti D, Sassi F. et al. Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations. Clin Cancer Res. 2011;17:3146-56
18. Lang AH, Geller-Rhomberg S, Winder T. et al. A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients. BMC Cancer. 2012;12:20
19. Schmid F, Burock S, Klockmeier K. et al. SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer. Mol Cancer. 2012;11:49
20. Carlson CS, Eberle MA, Rieder MJ. et al. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet. 2004;74:106-20
21. Yang YP, Qu JH, Chang XJ. et al. High intratumoral metastasis-associated in colon cancer-1 expression predicts poor outcomes of cryoablation therapy for advanced hepatocellular carcinoma. J Transl Med. 2013;11:41
22. Qu JH, Chang XJ, Lu YY. et al. Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol. 2012;18:2995-3003
23. Stein U, Burock S, Herrmann P. et al. Circulating MACC1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis. PLoS One. 2012;7:e49249
24. Marx V. Tracking metastasis and tricking cancer. Nature. 2013;494:133-6
Author contact
Corresponding author: Lin Zhou. Division of Hepatobiliary and Pancreatic surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University, 79# Qinchun Road, Hangzhou, Zhejiang, P. R. China, 310003. E-mail: linzhou19com. Fax:+86-571-87236466
Received 2013-7-11


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I have been a most negligent blogger...to go for more than a month without posting anything?! I am ashamed. But I am also repentant and therefore hope you will forgive me.
To demonstrate the genuineness of my contrition, I am starting today a project that will continue daily for the next 7 days. Each day, I will post a word and associated photo, accompanied by a brief reflection. Although the photos and words have already been chosen (and are also posted in my office), I have no idea what I will write each day as I undertake this. But I will write something.
However, the project is not intended to stop there. I am also inviting readers, new and old, to also share reflections on these words/photos. Since this blog is not set up to accept comments, you may e-mail me your reflections, art, poetry, etc. related to the day's topic. Then, in approximately 2 weeks, I will do another 7 day cycle, posting the submissions of others. The reflections/art do not need to be "good", i.e. I don't want anyone to hold back because they think that whatever they might submit would be unworthy. The purpose of this is to share. Even if you think you have nothing to offer, consider that something might be offered through you for the benefit of an unseen other. This is not a contest. It is a gift-fest.
There are to be just a few basic ground rules:
(1) Since it is my blog, I have the right to decide if I think it is better not to post someone's submission. I don't imagine that I will need to invoke this much if at all but it is important for me to put it out there. If you submit something that I don't think should be posted, I will e-mail you back and explain why. (You would then have the option to modify whatever might be the "problem".)
(2) Please keep your submission consistent with the blog's nature and topic, e.g. offering hope, being respectful of others' beliefs (or lack thereof), etc.
(3) Please do not submit anything that is not yours, i.e. poetry, photos, videos, etc. that you do not own the rights to. If you are quoting someone, please say who you are quoting. If you want to include a link, I will check it out and allow it if it checks out OK.
(4) I need to know who you are - so please give me your name in your e-mail. (If I don't know you personally, it would also be helpful to know how you came to the blog.) I will not print your full name unless you ask me to (e.g. if your material is copyrighted or you want to offer a link to your own blog or art). Generally, I would discourage the use of full names for posting purposes and would ask you to tell me what identifier you would like me to use (e.g. initials, made-up name, etc.). If you don't tell me your preference, I will call you "anonymous".
(5) If you are a patient of mine, you are most welcome to participate but please do not submit anything here that is intended to be a clinical communication with me. If you need to talk to me as your psychologist, contact me as you normally would.
(6) You may submit something for each of the 7 days or for just one. There are no rules regarding this - as long as you don't spam me! (approximate deadline for submissions is August 5th).
So - send any e-mail submissions (indicating what day it is associated with), with your full name (will be kept private) and the identifier you would like me to use instead of your name to: email@example.com
(Please do not use this e-mail address for anything other than this 7 day project because I do not otherwise monitor it regularly.)
So open yourself...allow gifts of words, images and sounds to be given through you...


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DJ Tony E
Disc Jockeys: (6 miles away from Riverside)
A DJ Company entertaining Southern California and the Inland Empire Since 1982. Playing today's top hits, Motown, Country, Salsa..The list goes on... We have more than 3000 songs selections in our music library. Not only do we provide a wide selection of music we have the ultimate attractions for your eyes....With the lastest in smart lighting effects to be combined with our sounds BTBB creates a sound and visual sensation. To help you dance the night away.Get Quote
MixFresh Entertainment
Disc Jockeys: (9 miles away from Riverside)
We provide service to all types of occasion. Weddings Receptions Graduation Parties Club's dj's Birthday Parties Private Parties Divorce Parties Bachelor/Bachelorette Parties Block Parties CoprorateGet Quote
Dynamic Entertainment
Disc Jockeys: (18 miles away from Riverside)
Dynamic Entertainment is a premiere provider of high-quality professional DJ services for all types of events. I specialize in weddings, corporate and private parties. I am a member of the ADJA (American Disc Jockey Association) and carry my own insurance! I am well known for being able to provide both an elegant low key wedding or high energy crowd interaction - it is your choice! I have served literally thousands of clients throughout the state of California (Los Angeles, Orange County, San Diego, Riverside County and Inland Empire) since 1993. I have...Get Quote
The Realm of Entertainment, LLC
Disc Jockeys: (22 miles away from Riverside)
Currently offering event coordination, professional DJ and MC hosting services, and mobile bartenders/servers.Get Quote
Disc Jockeys: (31 miles away from Riverside)
BumpIt Entertainment is a full entertainment service provider. We have multiple DJs on staff, Professional MCs, Bartenders, Casino Dealers and more. Additionally we rent items such as Dance Floors, uplighting, dance lighting, video screens, environmental effects casino tables etc. Our biggest advantage though is our creativity. We customize every event to best match the goals of the client – not ourselves. Planning, Punctuality, Personality and a Passion that we can't hide. Call today and we'll prove it to you.Get Quote
Disc Jockeys: (41 miles away from Riverside)
DJ/MC SERVICE KARAOKE SET UP'S DJ LIGHTING FX AND STAGE LIGHTING FX SOUND ENGINEERING FOR BANDS AND CONVENTIONS, AND CORPERATE EVENT'SGet Quote
Social Chemistry Events
Disc Jockeys: (42 miles away from Riverside)
Whether you choose to use one of our amazing wedding planners, artistic photographers or energetic DJs, you know Social Chemistry Events has the experience to make your day special. Decades of experience will help take care of all the small details during your event. Our DJ's have access to over 80,000 songs, from the Roaring 20's, to the Hottest Top 40 hits of today. Our Wedding Planners can help you out with your own online planning forms and itinerary. And of course our photographers will have you looking your best! Your event will flow smoothly from beginning to end...Get Quote
The Entertainment Elite
Disc Jockeys: (44 miles away from Riverside)
Since 1999 we have been the #1 requested DJ service for school events, weddings, and corporate functions. Whether you want a low key event, or high energy party our DJ's have the necessary experience to create the perfect atmosphere for all of your guests. Visit our website for more information: TheEntertainmentEliteDJs.Com Featuring music from the 40's to Top 40's of today! Our quality professional compact sound systems offer sound quality unparalleled by much larger sound systems other services. Lighting, Event Add-Ons, Glow Necklaces and more available upon request. Call us today for more information!Get Quote
Disc Jockeys: (54 miles away from Riverside)
Weddings, high school eventsGet Quote
Beni Swift
Disc Jockeys: (56 miles away from Riverside)
Disc Jockey/MC/Entertainer for all occasions including: Clubs, anniversaries, birthdays, reunions, graduations, outings, holidays, special days, corporate.Get Quote
Dj Ssins
Disc Jockeys: (59 miles away from Riverside)
at moondanceproduction.com We are proud to provide you with the finest in Professional Photography, Experienced DJ's, Lighting, Video Montage, Karaoke and System Rentals We provide atmosphere and ambiance for a wide variety of social gatherings AND record it for posterity. When you plan your next event, don't underestimate the importance of professionalism. Our DJ and Photographer team is unparalleled in service, quality and value.Get Quote
Elegant Entertainment
Disc Jockeys: (64 miles away from Riverside)
My name is David Sivits (DJ Soleil) and I am a DJ/MC. A party DJ/MC can make or break the event. The evening will have a nice flow or arc; inspiring the guests to talk more laugh more, and enjoy themselves, or have a jagged feel as if an ipod is blindly selecting music. It's always my goal to lead the party to the next level. Either by gently increasing the energy of the party or slowly bringing the party to a close, I guarantee the music will fit your needs perfectly. As a MC, I accent...Get Quote
Joey Best
Disc Jockeys: (86 miles away from Riverside)
One or Two Man Teams for Weddings. My Specialty is Wedding Entertainment. I customize the music and fun to the level you want. My equipment is truly state of the art. I have literally 52,000 songs with me from the 40's to today. By using computers to control the sound and light levels, you are assured the best quality from any disc jockey. In addition, and I believe I am unique with this feature, I can download a song within 10 minutes on location at YOUR wedding reception, from a 10 million song database! This has proved invaluable for...Get Quote
FLip 2 Syde Mobile Dj's
Disc Jockeys: (88 miles away from Riverside)
Specialize in all Music, hip hop, R & B, Rapp, Dance hall, Disco, Old School funk and Electic, Freestyle. Our goal is to Give Bring The Club To You. There is no Event thats to small or to Big.Get Quote
Dave Parsons
Disc Jockeys: (7 miles away from Riverside)
P.R. Attractions DJ's are professionals who are dedicated to customer service. They are experienced in the requirements of successful Weddings, Receptions, Birthdays, Anniversaries, Corporate banquets, Holiday parties, and Social gatherings of every kind.Get Quote
Party Planet DJs
Disc Jockeys: (13 miles away from Riverside)
Have you been searching high and low for the right mobile DJ company for your next special event? Then look no further because you've come to the right place! That's because the Party Planet DJs are more than a mobile DJ company. The Party Planet DJs are a full-service mobile entertainment company committed to bringing you the absolute best...Get Quote
Newport Beach DJs
Disc Jockeys: (38 miles away from Riverside)
"Name Your Price" option! 1-2 djs in formal, casual or theme party attire. Quality sound systems, wireless mics, lighting effects(including fog/haze), trivia with giveaways, itinerary assistance, complimentary consultation, no charge for travel or set-up. Credit cards accepted & references available.Get Quote
Integrity Mobile Audio
Disc Jockeys: (63 miles away from Riverside)
Integrity Mobile Audio specializes in engineering and entertaining for a wide variety of special events including: corporate, live sound, weddings, and private parties. Offering the most affordable prices and the highest quality of service and equipment. Give us a call at 1-877-217-9931 (toll free) or 760-799-8210 (local) for a free quote and let us make your next special event successful and...Get Quote
Disc Jockeys: (4 miles away from Riverside)
Welcome to Classic Image Mobile Music, a D.J. entertainment company dedicated to exceeding your expectations. I've been entertaining the Southern California area since 1990. I believe in giving you personal attention to every detail, allowing you to customize every aspect...Get Quote
C.P. Entertainment
Disc Jockeys: (4 miles away from Riverside)
We Provided service for Weddings, Birthday, anniversary, christmas partys, picnics private partys Music for all occasions!!! all @ low special prices guaranteed!!!!!!!!! Just give us a call will give you a great quote thanks for looking have aGet Quote
Bring That Beat Back
Disc Jockeys: (6 miles away from Riverside)
Bring That Beat Back, your full Dj service company, ensures to provide great entertainment for all of your "Once in a lifetime "occasions". Our goal as DJ's is to give you a party experience that is unique, never the routine.Get Quote
Soundskilz Entertainment, Inc
Disc Jockeys: (7 miles away from Riverside)
We pride ourselfs in our ability to provide our clients with "everything they want for a wonderful event." We have everything from the basic sound system and DJ to do a backyard party; to full scale audio-video, lighting and...Get Quote
DJ RuDe aka DJ Pauly P
Disc Jockeys: (8 miles away from Riverside)
Unique Entertainment Mobile DJs & Karaoke offers comprehensive event entertainment services, perfect for any occasion. Our company of experienced DJs will use their talent and expertise to create the soundtrack for your memorable event. If you want a spectacular event...Get Quote
U-DJ Rental Systems, Inc.
Disc Jockeys: (8 miles away from Riverside)
U-DJ Rental Systems caters to the do-it-yourself market for Disc Jockey, Public Address and Karaoke equipment designed for ease of use and reliability. We rent complete easy to use professional DJ equipment, delivered and setup at your event and taken...Get Quote
DJ Dann-Mega
Disc Jockeys: (9 miles away from Riverside)
Provide sound re-enforcement and music for events. Also, have the ability to provide live sound (PA) for up to 5,000 people.Get Quote
DJ Mstr Lee
Disc Jockeys: (9 miles away from Riverside)
Play Music for audienceGet Quote
Disc Jockeys: (9 miles away from Riverside)
Not every one can successfully DJ at a party or especially a wedding. Many people do not have the musical knowledge, technical skills, announcing skills, or motivation to do a professional job. Most people do not have the experiece to...Get Quote
Disc Jockeys: (9 miles away from Riverside)
We offer Quality Sound, Lighting and Great Entertainment.Get Quote
Creative DJs
Disc Jockeys: (11 miles away from Riverside)
Visit our official website at www.creativedjs.com We have over 15 years experience entertaining at events. Our Disc Jockeys are polished Professionals who will make your event fun and memorable. We play at all types of events including wedding ceremonies...Get Quote
Final Touch Entertainment
Disc Jockeys: (14 miles away from Riverside)
Mobil DJGet Quote
Disc Jockey Djs
Disc Jockeys Prices for a Riverside Wedding DJ
All our DJs are local and perform in the Riverside area. To find a dj or to "rent-a-dj", you've come to the right website! Our local Disc Jockeys are the best because you can meet with them to go over your plans prior to your event. Some even have professional offices where they can meet directly with you. They can even do an in-home meeting, even perhaps meet with you directly at the facility or venue in which you are having your event. We'd like to say that we have the "best djs for a Wedding or other event" but we will leave that up to you! How to Book the Very Best in DJ Entertainment
Whether it's a Event or it's simply the middle of the holiday season, there's always a good reason to throw a party, and the trick to throwing a great party is to book the right entertainment. Here are some terrific tips to help you book the very best entertainment for your next party:
How to Book the Very Best in DJ Entertainment
Whether it's a friend or relative's birthday, Bar Mitzvah, Quinceanera, graduation, anniversary, house warming or it's simply the middle of the holiday season, there's always a good reason to throw a party, and the trick to throwing a great party is to book the right entertainment. Here are some terrific tips to help you book the very best entertainment for your next party:
Party planning is stressful enough on its own. Don't let booking your entertainment add to your burden. Follow these tips and you're guaranteed to book the very best in party entertainment!


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51 Drakes Landing, Hampton, NH
Presented By:
$ Click for current price
3 BEDROOMS | 4 (2 full, 2 half ) BATHROOMS | 2684 SQUARE FEET
When you walk into this home you are greeted by a 2-story vaulted ceiling filled with natural daylight that opens to the living room with its easy maintenance gas fireplace that exudes fireside ambiance. Enhanced by the warmth of the wood floors that openly flows into the formal dining area where your guests will naturally gravitate to, provides the perfect setting used as a social entertaining space and also located just off your eat-in kitchen. Makes entertaining pretty effortless. The large kitchen offers gas cooking with upgraded Stainless appliances along with plenty of cabinet storage. Sliders off the Eat-in area take you outside to enjoy your private and peaceful times during warmer days on your large deck. A first floor half bath laundry room is conveniently tucked down the hallway off the attached Garage entry. This floorpan does not have a first floor Master Bedroom, however it does have a Partial Finished Basement that includes a large bedroom with closet and ensuite Bathroom. That's a total of 4 Bedrooms and 4 Bathrooms. This finished basement has enough space to be used as a media room, home gym or in-law suite. The long drive on this premium lot provides plenty of parking for guests. The home has many recent updates. Whole house recently painted, new Boiler and more… See the attached Upgrade Sheet. Move in ready. Amenities include Club house with in-ground pool. Close in town proximity with easy access to highways. Don't miss out. Request a showing today.
RE/MAX on The Move 43 Water Street Exeter, NH 03833 603-777-1500 If your property is currently listed with a real estate broker, please disregard. It is not our intention to solicit the offerings of other real estate brokers. Information is deemed reliable, but not guaranteed.


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Nikita Cast Interviews: Meet Michael, NikitaMatt Richenthal at . Comments
On The CW's Nikita, Shane West and Maggie Q square off.
The actors play characters on the opposite side of justice, as West's Michael formerly employed Q's Nikita. When we meet them in the series premiere, however, the relationship has fizzled. To say the least.
In separate interviews below, two of the show's main stars speak in depth on the character they portray. Who is Michael? What motives Nikita? Find out now.
[video url="http://www.tvfanatic.com/videos/meeting-michael/" title="Meeting Michael"] [/video]
[video url="http://www.tvfanatic.com/videos/who-is-nikita/" title="Who is Nikita?"] [/video]
Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.


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Cassville in Grant County, Wisconsin — The American Midwest (Great Lakes)
Historic Cassville Ferry
—Wisconsin's Maritime Trails —
In the 1890s, the horse-powered ferry carried sweet corn, peas, and cabbage from Iowa's fertile farmlands to the cannery of the Klindt Geiger Canning Company in Cassville. The ferry was modernized with a gasoline engine in 1913. In 1918, the original, wooden ferry was replaced by a 25-ton, steel-hulled vessel that carried six automobiles. Records show that in 1924, the ferry carried 2,238 automobiles and 17,456 passengers across the Mississippi during its eight-month operational season.
Ferry service in Cassville was interrupted in 1940, when an extensive system of locks and dams were built on the Mississippi. However, memories of Cassville's ferry endured among the town's citizens.
In the 1970s, an unsuccessful effort to build a bridge at Cassville rekindled interest in a ferry line. In
Wisconsin Historical Society
Wisconsin Department of Transportation
Sea Grant · University of Wisconsin
Erected 2009 by Wisconsin Historical Society; Wisconsin Department of Transportation; Sea Grant · University of Wisconsin.
Marker series. This marker is included in the Wisconsin's Maritime Trails marker series.
Location. 42° 42.806′ N, 90° 59.529′ W. Marker is in Cassville, Wisconsin, in Grant County. Marker is on Prime Street 0.2 miles west of Wall Street. Touch for map. Marker is in upper Riverside Park. Marker is in this post office area: Cassville WI 53806, United States of America.
Other nearby markers. At least 5 other markers are within 13 miles of this marker, measured as the crow flies. The Cassville Veterans Memorial (within shouting distance of this marker); Denniston House (about 400 feet away, measured in a direct line); Village of Cassville (approx. 0.2 miles away); Pleasant Ridge (approx. 12.2 miles away); a different marker also named Pleasant Ridge (approx. 12.7 miles away).
More about this marker.
[photo captions counterclockwise]
• The Cassville Ferry with three cars and passengers, about 1918. Photograph by Frank W. Feiker, Wisconsin Historical Society
• Farmer Martin Anderson poses with a cabbage, 1895. Wisconsin Historical Society
• A label from the Klindt-Geiger Canning Company. The company was incorporated in 1893 to can pickles and sauerkraut and was known locally as "The Pickle Factory." It later added tomatoes, corn, and peas. Courtesy of Cassville Tourism
• Background image: View of Cassville and the Mississippi River from the bluffs, about 1910. Photograph by Frank W. Feiker, Wisconsin Historical Society
Also see . . .
1. Cassville Car Ferry Website. (Submitted on June 23, 2011.)
2. Cassville Car Ferry. (Submitted on June 23, 2011.)
3. Wisconsin Maritime Trails. (Submitted on June 23, 2011.)
4. Wisconsin's Great Lakes Shipwrecks. (Submitted on June 23, 2011.)
Categories. • Waterways & Vessels •
Credits. This page was last revised on June 16, 2016. This page originally submitted on June 23, 2011, by Keith L of Wisconsin Rapids, Wisconsin. This page has been viewed 557 times since then and 3 times this year. Photos: 1, 2, 3, 4. submitted on June 23, 2011, by Keith L of Wisconsin Rapids, Wisconsin.


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Well it's another beautiful but hockey news impaired day in Montreal. NOTHING has hapened in the last few days, save for Vaclav Prospal signing with the Rangers and the Canucks inking russian prospect Sergei Shirokov to an NHL contract.
Sergei Shirokov.... the second coming of Pavel Bure.....
Anyway I have decided to put up a list of people that I feel exemplify all that is boss in the world of Hockey. It is an exclusive list of only 10 people, and each month I will re-evaluate it, tweaking it here and there. So here it is. The inaugural version of E's BAWSS list.
1. Sidney Crosby - Youngest Stanley Cup winning captain ever. All the honeys back in Cole Harbor must be ordering alot of "Sid the Kid blowup love dolls".
2. Evgeni Malkin - Player with the most points ever in one playoff who wasn't named Gretzky or Lemieux. Looking good Gino.
3. Max Talbot - Max Poooowwwwwweeeerrrr......
4. Darren Helm - St. Andrews Mantioba's favorite son is speedster with heart who became a fan favorite in Detroit this year in the Playoffs.
5. Dan Cleary - The first Newfie to win a Stanley Cup put up big numbers this year and made a name for himself.
6. Travis Moen - One of the newest Habs is one of the best shut down players in the league and will give the Canadiens some much needed grit.
7. Scott Gomez - Anyone from Anchorage Alaska is cool...no pun intended, and he is taking french lessons so he doesnt put himself in a position to be attacked by the blood thirsty jackals.
Otherwise known as the French Media.
8. Alex Ovechkin - Everyone will be watching to see if Alex the Gr8 can be the first player since Wayne Gretzky to score 55 or more in three straight seasons.
9. Glen Metropolit - The only player I know from the ghetto.
10. Steve Mason - Youngest age I've ever seen a goalie truly kick ass and take names in the NHL.


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Tire whiskers
I lined this shot up while the Indy cars were lined up to go out for a practice session.
Zach Veach
Zach Veach looking good during one of the practice sessions on Friday at the Honda Grand Prix of St. Pete.
Flat spotting the tires
Learning the limits during one of the Friday practice sessions at the Honda Grand Prix of St. Pete.
22 March, 2013.


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About Georgina Scott Bridal in Stourbridge and Kingswinford
Georgina Scott Bridal was established at The Chapel in Stourbridge, a stunning historic venue which has been expertly converted into a sumptuous boutique for our brides. The Chapel provides us with the perfect setting for our ladies and their guests to relax and enjoy the most luxurious wedding dress shopping experience possible.
With over 15 years experience in the bridal industry, Georgina Scott Bridal is a family run team which strives to put brides first and ensure they have a magical experience when it comes to choosing their perfect wedding dress. With access to a huge selection of some of the world's top wedding dress designers, our ladies have a massive collection to choose from and we will help them in every way we can to find the ultimate dress which gives them the wow factor.
We understand that our brides often have a set budget in mind when it comes to choosing their wedding dress, and we are pleased to be able to offer dresses to suit a range of prices, from just over £750 up to £4,100. Our accessory collection is vast, and brides can try on individually designed headpieces, veils, sashes, boleros, fur wraps, vintage furs (please note our furs are for hire only), garters and jewellery. The accessories can be tailored to suit the brides' individual needs, so they can leave the boutique feeling they have an outfit which is just as unique and special as them.
Buying from Georgina Scott Bridal means you can be confident that we provide the very highest standards of quality, service and professionalism, and you will find:
- We are a VAT-registered retailer which pays business rates to the local council and has over five years' trading experience.
- A business that is financially sound, offering professional standards of care and service with high standards of stock and decor.
- Trained staff dedicated to the welfare of the bride and groom.
- Scores of Thank You notes and photographs from satisfied clients.
- A privately-owned family run shop, with no connection to impersonal 'multiple' chains.
And remember that:
- We offer a full alterations service on your wedding dress as part of the total service for the bride, although normally this is a service that is charged separately from the cost of your gown.
- Our insurance policies cover gowns in storage prior to the wedding day.
- We require brides to pay only 50% of the price of their goods on ordering*.
Our hard work and dedication to the industry has not gone unnoticed, as the Georgina Scott Bridal team have won a number of prestigious awards, including:
- Best Bridal Retailer in the UK by The British Bridal Awards 2016
- Shortlisted for the 2016 The British Wedding Awards
- Region's Best Bridal Retailer by The Wedding Industry Awards 2015
- Best New Bridal Boutique 2013 by The Bridal Buyer
To read some feedback and comments from our brides, please take a look at our Facebook and Instagram pages.
In order to make sure our brides have the full attention they deserve, we operate an appointments system. We particularly recommend that brides book an appointment if they wish to visit our boutique on a Saturday. Our current opening hours are as follows:
Monday, Wednesday and Friday – 10.00am to 5.00pm
Tuesday and Thursday – 10.00am to 8.00pm
Saturday – 9.00am to 5.30pm
Sunday – 11.00am to 4.00 pm
We have 3 private dressing rooms and we always welcome walk-ins. However appointments will have priority over the dressing rooms.
To make an appointment, simply give our team a call on 01384 893656 or email email@example.com.


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Hiyaaa Beauties,
Gyaaaaa Beauties...This is my first make up challenge after joining a Beauty world a month ago. Aaaaaah my hand is shaking with excitement. In analogy, I am like a newborn baby trying to walk..I hope I won't fall and bump a table ;-p
Please, be nice to me commenter. I am new at this. But I really hope you will like my look for this challenge.
The theme that I choose is "The Gold Beauty".
Here is a picture before putting on some makeup.
I added some line using lip liner first to make it easier shaping the mask.
These are the almost finish to finish look.
Finally with a messy hair look for a finish.
I am wearing tank top in the last 2 pictures but my hair makes it look like I am almost topless hihihi..
I am not sure if I am gonna win the MUC. But I had a good time trying this make up..so winning is not my goal. Learning and process of doing were achievement as baby step for me, a newborn Beauty Blogger. I hope you like this look and feel inspired to create your own look.
If you are interested in joining MUC and getting the awesome price from D'Eyeko, you may find the link here in; Indonesian Beauty Blogger, Make Up Challenge, IBB MUC
You will find out how to do the challenge in the link above. I hope you will have as much fun as I did.
Cherios Chikas,
Suci Park
Tuesday, December 10, 2013
IBB Make Up Challenge December 2013
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MapleStory2 PC requirements Info
MapleStory 2 has been developed with older and newer computers in mind, allowing everyone to partake. Specs and computer requirements are below.
Low Quality
WinXP SP3 32bit
CPU: Core2Duo
Ram: 2GB
Graphics: GeForce 9800 / Radeon HD 4000
Medium Quality
VISTA/Win7/Win8 32bit
Ram: 2GB
Graphics: GeForce GT 400 / Radeon HD 5000
High Quality
Win7/Win8 64bit
Ram: 4GB
Graphics: GeForce GT 600 / Radeon HD 6000
Ultra High Quality
Win7/Win8 64bit
CPU: 5 and up
Ram: 4GB
Graphics: GeForce GT 600 / Radeon HD 6000


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Once you land at Bandaranayake International Airport (BIA / CMB), your friendly driver will meet you and drive you directly to your holiday destination. Whether youre travelling individually, with a partner or in a group, your ground transport needs will be covered by this private airport transfer service. Avoid the confusion of taxis or public transport and enjoy a hassle-free start to your vacation. Airport transfers have never been this easy! Travel in style and comfort with unparalleled safety in our luxurious cars and get to your destination in good time and great order. Your English-speaking chauffeur is always at your service.
Tour Information
Key Details
- Mobile Voucher Accepted
- Hotel pickup Available
- Free Cancellation
- Duration: 7 Hrs
Departure Time :
Your chosen time
Departure Details :
Colombo Bandaranayake International Airport (CMB/BIA)
Return Details :
Your hotel in Haputale
Start your Sri Lanka holiday with ease by booking this private arrival transfer from Colombo Bandaranayake International Airport (BIA / CMB) of Sri Lanka to your hotel in Haputale. Your friendly and professional driver will greet you upon your arrival and drive you directly to your holiday destination in the comfort of a private, air-conditioned vehicle. Its that easy!
Know More about this tour
- One-way airport transfer
- All taxes, fees and handling charges
- Excess luggage charges (where applicable)
- Food and drinks
- Gratuities (recommended)
Additional Info
Confirmation will be received at time of booking
Adult pricing applies to all travelers


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CLS single use accessories evaluated by Laser Prostate Centers of America in Texas, USA
Clinical Laserthermia Systems (CLS) (publ), has, through its subsidiary CLS Americas Inc., received an order from Laser Prostate Centers of America (LPCA), regarding CLS single use accessories for MRI-guided laser ablation. LPCA, who is a new CLS customer, will evaluate the company's products for focal laser ablation (FLA) treatment of early stage prostate cancer. The value of this initial order amounts to about 55 000 SEK.
- Laser Prostate Centers of America is specialized in focal laser ablation treatment and holds advanced competence in interventional radiology and urology. The team also has solid technical knowledge, which brings additional value to this business relationship, said Dan Mogren, CCO at CLS.
Prostate cancer is the most common type of cancer among men. In the US, 200 000 new cases are expected every year. FLA is a gentle treatment alternative compared to surgery and radiation, which often damage surrounding tissue and give side effects such as incontinence and erectile dysfunction.
Laser Prostate Centers of America is based in Houston, Texas. Read more.
This press release has been translated from Swedish. The Swedish text shall govern for all purposes and prevail in case of any discrepancy with the English version.
Lars-Erik Eriksson, CEO, Clinical Laserthermia Systems AB (publ)
Tel: +46 – (0)702 – 90 33 00 E-mail: firstname.lastname@example.com
Clinical Laserthermia Systems AB (publ), develops and sells the TRANBERG®|Thermal Therapy System and specially designed sterile disposable products for safe, gentle and effective treatment of cancerous tumors. The products are marketed for image-guided laser ablation and for treatment with immunostimulating interstitial laser thermotherapy, imILT®. The company, which is headquartered in Lund Sweden and have subsidiaries in Berlin, Germany and Boston, MA,USA, is listed Nasdaq First North under the ticker CLS B. Certified Adviser is Västra Hamnen Corporate Finance. Further information is available on the company's website: www.clinicallaser.se


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This is a special bracelet, with a silver foiled teal puff coin glass bead as the focal piece. The glass bead measures 2cm in diameter and sits nicely on your wrist. Aquamarine seed beads and antiqued space beads help to accentuate the entire design.
Sale price: US$17/S$25
(Penny is of limited edition as there is only one of that glass bead available. There is will be no remakes of this design, so you are sure it is OOAK if you get it!)


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Delta Home
Flight Log
Current News
Upcoming Launches
Frequently Asked Questions
Programs and Links
Vehicle Description
Performance Specs
To Reach the High Frontier: A History of U.S. Launch Vehicles
"A valuable contribution to the field of aerospace literature," this book includes an extensive overview of Delta history and development along with chapters on Atlas, Titan, Scout, Space Shuttle, and much more.
Many other excellent books about spaceflight are recommended here.
History of the Delta Launch Vehicle
Current Delta News
(What about Delta IV?)
23-Feb-99 | Delta flight 267 – Argos P-91
Finally! After months of delays due to spacecraft hardware problems, and weeks due to vehicle hardware and the weather, Argos P-91, the largest experimental satellite ever flown by the Air Force, launched from Vandenberg AFB at 02:29 PST on 23 February.
Two hitchhiker payloads, Ørsted from Denmark and Sunsat from South Africa, were also successfully deployed. Argos is carrying an array of 9 high technology experiments to demonstrate next-generation satellite technology.
Delta 267, thanks to the numerous delays in the development of Argos, spent at least one year (possibly close to two) in storage at Vandenberg, yet it needed only to be dusted off to be ready to fly. That, and the fact that the Aerojet second stage spent over a month loaded with highly corrosive hypergolic propellants without leaking, are testaments to the robustness of the Delta design. This flight set a record for Delta II launch attempts, 11, though most of the scrubs were not caused by the vehicle:
- 15 January: scrubbed due to upper level winds.
- 16 January: scrubbed due to three problems: upper level winds, range considerations that winds could cause debris from an accident to fall outside the safety area, and a problem with a destruct command transmitter at a downrange tracking station.
- 20 Jan, debris concerns.
- 21 Jan, debris concerns.
- 22 Jan, upper level winds.
- 26 Jan, postponed due to weather; no operations begun.
- 27 Jan, upper level winds.
- 28 January was aborted following the engine start command, when one of the two vernier engines failed to ignite. This was likely the result of several days of tanking and detanking with liquid oxygen, causing frost to form on the first stage tank which would then melt and drizzle through the engine section.
- 07 Feb, debris concerns.
- 12 Feb, upper level winds.
- 13 Feb, spike in one of the power sources to the 1st stage electronic control package.


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She is,
The honey that melts in the mid-summer heat,
and the nectar imported through the cold.
She is the crown that rests atop of her shoulders,
and poised,
like the curved cuts of her silken trousers,
and weighted
with the pearls that embellish her cotton shirt.
humming rhythmically
the boil on the remnants of Darjeeling
whilst fastening her trench like coat.
She is,
The gold welded through her ancestry,
overseas but grounded.
She is the tea that is brewed twice over.
– A post-colonial memoir
Read more of my prose @auburnrhyme
As always, feedback would be greatly appreciated.


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After the renovation of the house, how to choose our furniture? For example, the living room, in the face of different home style, our living room home products to do with the decoration style uniform? Let's have a look!
european style Style: European style living room, are generally relatively spacious, gorgeous and elegant romantic highlights;
Furniture choice: European style living room must be equipped with European style sofa, let the living room has a kind of elegant ultra comfortable feeling, show consistent style.
Chinese style
Style: Chinese style living room, pay attention to the format of symmetrical layout, with a calm color Qing style Louhua decoration, a complete outline of classical style;
Furniture choice: the choice of Chinese elements of the sofa, the color should be relatively deep, in order to better reflect the deep and elegant Chinese style.
Style features: modern minimalist style of the room, the decoration line simple and lively; more suitable living room area of about 100-119 square meters, aged between 25-40 years old and middle-aged white-collar;
Furniture choice: in furniture configuration, the best selection of simple fashion style, avoid elaborate decoration, can use exaggerated color collocation, make space full of inherent rhythm.
american style
Style characteristics: American classical rural style in color and modeling is more reserved and conservative, with comfortable function oriented, both classical and modern lines;
Furniture choice: easy choice of material with white oak, mahogany, or cherry wood, simple lines, without carving, still retains the original wood texture and texture, create a rustic texture.
Mediterranean style
Style: to give people the feeling of recover the original simplicity also reflects, to a higher quality of life pursuit;
Furniture: furniture color with white as the main body, also the rich colors of the Spanish style, make furniture classical furniture showing some texture, showing more furniture, the sea breeze was blowing natural erosion under the Mediterranean Bihaiqingtian imprinting.
Hangzhou PT Furniture Co.,ltd
Address:Dongzhou Industrial Area,Fuyang City,Hangzhou,China
Previous: The classification of office furniture


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TLC creates custom reveals and entrances for your event or show. Launch your new logo or reveal the guest of honor with the dramatic impact of a kabuki, or screen drop reveal.
Imagine the audience thrill when stretched fabric screens that feature lasers or a projected video or logos or lighting cues set to a dynamic audio-mix SUDDENLY DISAPPEARS from view, revealing your featured guest, CEO or product. Exciting meeting openers can make a big difference in your audiences' impression; and adding a TLC screen or fabric drop or pull-away is a memorable show cue your guests will enjoy. TLC designed and created the LAKERS PRE-SHOW featuring a cylinder of video projected on a revealed then dropped-screen.
TLC adds impact and excitement at all types of events with dramatic reveals and live special effects.
Disappearing Balloon Wall!
Fog Burst Effects
Show openers and closers, think LASERS! and PYRO! to add spice and create excitement and energy in corporate meetings and events.
TLC creates custom reveals and entrances for your event or show. Launch your new logo or reveal the guest of honor with the dramatic impact of a special effects and laser show featuring a kabuki, or screen drop.
August 4, 2018
Connect your guests with the power of light! Xyloband Lanyards create synchronized, immersive experiences that create energy and excitement at all kinds of events. Motivational […]
March 20, 2018
TLC recently created live special effects for new Nissan Altima car national campaign. The exciting ads feature TLC fog bursts, confetti drops, and a custom staged […]
January 20, 2018
TLC Creative presents GlowBalls – wireless LED spheres of light. GLOWBALLS – wireless LED spheres for interactive experiences. Glowballs use Xylobands RGB LED wireless technology for […]
October 22, 2017
New technology white sparkle fountains are ready to energize your audiences! Brilliant bursts of sparks, fog, confetti, all add layers of thrill to crescendos and climaxes. […]


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Facial nerve paralysis is a common problem that involves the paralysis of any structures innervated by the facial nerve. The pathway of the facial nerve is long and relatively convoluted, and so there are a number of causes that may result in facial nerve paralysis. The most common is Bell's palsy, an idiopathic disease that may only be diagnosed by exclusion.
Facial paralysis is almost always caused by:
In people who are otherwise healthy, facial paralysis is often due to Bell's palsy, a condition in which the facial nerve becomes inflamed.
Stroke may cause facial paralysis. With a stroke, other muscles on one side of the body may also be involved.
Facial paralysis that is due to a brain tumor usually develops slowly and causes headaches, seizures, or hearing loss.
Use spaces to separate tags. Use single quotes (') for phrases.


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Abhi-Aish to celebrate Happy Anniversary
26 Sep, 2013 - 02:44 AM IST | By indiantelevision.com Team | 153 Reads
Ad maker Prahlad Kakkar, best known for his work on the famous Pepsi TV commercial with Amitabh Bachchan and Sachin Tendulkar is planning to dip his hands into Bollywood filmmaking.
His upcoming flick will see the comeback of the gorgeous diva Aishwarya Bachchan. The film tentatively titled Happy Anniversary will be produced by Gaurang Doshi and will explore the anatomy of marriage.
Ash's hubby Abhishek Bachchan will be playing the male lead and the two will be seen sharing the screen space after a span of five years since their last film Guru in 2007.
Happy Anniversary will be shot in Africa and is slated for a release in January 2014.


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Jedediah Bila Married, Husband or Boyfriend, Salary and Net Worth
Published On: 30 Aug, 2016
Quick Information
|Date of Birth
|January 29, 1979
|39 Years 11 Month(s)
|TV Host
|Marital Status
|Jeremy Scher (m. 2018)
|Not Yet
|Net Worth
|$1.5 Million (Approx.)
|Social Media
|Instagram, Twitter
|Not Yet
|5 Feet 5 Inches (165 cm)
|Columbia University
Famous American young and beautiful journalist, Jedediah Bila:
Famous American television personality and radio presenter, contributor to 'The View, columnist' and author of the book ' Outnumbered: Chronicles of a Manhattan Conservative', who was also ex-Fox News Contributor, she is Jedediah Louisa Bila professionally known as Jedediah Bila. She was born in Brooklyn, New York, the USA on 29th January 1979. The lady was graduated within a BA Spanish and minor Business Administration from the Wagner College and also got a Master of Arts from the Columbia University in Spanish literature, but the lady holds the American nationality.
Career Rise:
She has been a frequent visitor on Fox News, Fox Business, MSNBC, and talk radio all over the country. The lady has served as a dean in high school where she has also served as an advisor, and also spent many years as a lecturer in the City of New York as well. The lady reminisces the time she decided to venture into the political arena, while her media career started from 2008 presidential election. Jedediah began to write furiously and started airing her view on dailies and publications, till the lady came to be a name to reckon with, and later hired her by Fox News as a TV presenter in the year 2013 and in 2014 Jedediah came to be a panelist on the famous talk program.
Net Worth and Salary:
The Fox News popular presenter Jedediah Bila has an estimated net worth to be $1.5 million dollars, currently in Fox News, Dana has a salary of over $200 thousand dollars annually with including all fees. The lady made this figure of amount through her profession and especially her dedication and laboring in her profession or jobs. And also she is an author, where her book hit the American books industry. Her book name is "Outnumbered: Chronicles of a Manhattan Conservative", which also number one New York Times best-selling books as well. So it seems that Bila is very enjoying and happy with her net worth and salary, best wishes her that makes huge money in next days as well.
Married, Dating, and Personal Life:
The lady has belonged white ethnicity and also has been ranked one of the sexiest lady news presenters there is today. She is also known for her long and sexy legs and distinctive features and her attractive face has managed to get her a huge and perfect fan following on the wiki or internet. But she belongs that news celebrity who kept their personal bio under cover. So she also has not revealed whether she has already married or dating with boyfriend, either she has a husband or divorce, where the lady perfectly kept about her married. Which, she has not opened any sites or any media. But sometimes the lady said in an interview that someone guy is attracted to her and also purposed her as well, but can't reveal his name. So, best wishes for her that marries soon and stays perfectly with your husband, family, and friends.
Age, Bio, and Facts:
The 37-years-old age American hot and beautiful journalist Jedediah Bila is standing with her average height of 5 feet 5 inches and also 56 kg of weights. The lady has a slim body figure with attractive body shape and figure with seductive body measurements with 34-25-35 inches. She also uses her social media, which also help to you to find about her bio and info.


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Sony added 17 titles to PlayStation Now today.
The majority of the titles are published by Disney Interactive Studios, including Disney Universe, Epic Mickey 2: The Power of Two, and more.
The list of games added can be viewed below.
- Disney Universe
- Lego Pirates of the Caribbean
- Split Second
- Epic Mickey 2: The Power of Two
- Tron: Evolution
- Toy Story Mania
- Monkey Island: Special Edition
- Pirates of the Caribbean: At World's End
- Monkey Island 2: Special Edition
- Cars 2
- Brave
- Cars Race-O-Rama
- Phineas and Ferb: Across the Second Dimension
- Cars: Mater-National Championship
- Bolt
- G-Force
- Ratatouille


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List of medical emergencies
Page ✜ Discussion ✜ Edit Page ✜ History
The following is a list of symptoms and conditions that signal or constitute a possible medical emergency and may require immediate first aid, emergency room care, surgery, or care by a physician or nurse. Please note that not all medical emergencies listed below are life-threatening; some conditions require medical attention in order to prevent significant and long-lasting effects on physical or mental health.
Injury and illness
- Abdominal pain, severe
- Appendicitis (leading to peritonitis)
- Ballistic trauma (gunshot wound)
- Head trauma
- Hyperthermia (heat stroke or sunstroke)
- Hypothermia or frostbite
- Intestinal obstruction
- Pancreatitis
- Peritonitis
- Poisoning
- Food poisoning
- Venomous animal bite
- Ruptured spleen
- Septic arthritis
- Septicaemia blood infection
- Severe burn (including scalding and chemical burns)
- Spreading wound infection
- Suspected spinal injury
- Traumatic brain injury
- Spinal disc herniation
- Lyme disease infection
- Malaria infection
- Rabies infection
- Salmonella poisoning
Cardiac and circulatory
- Aortic aneurysm (ruptured)
- Aortic dissection
- Bleeding
- Cardiac arrest
- Cardiac arrhythmia
- Cardiac tamponade
- Hypertensive emergency
- Myocardial infarction (heart attack)
- Ventricular fibrillation
- Acute renal failure
- Addisonian crisis (seen in those with Addison's disease)
- Dehydration, advanced
- Diabetic coma
- Electrolyte disturbance, severe (along with dehydration, possible with severe diarrhea or vomiting, chronic laxative abuse, and severe burns)
- Hepatic encephalopathy
- Lactic acidosis
- Malnutrition and starvation (as in extreme anorexia and bulimia)
- Thyroid storm
Neurological and Neurosurgical
- Attempted suicide, non-fatal
- Cerebrovascular accident (stroke)
- Subarachnoid hemorrhage
- Subdural hematoma, acute
- Convulsion or seizure
- Meningitis
- Syncope (fainting)
- Acute spinal cord compression
- Agonal breathing
- Asphyxia
- Asthma, acute
- Epiglottitis or severe croup
- Pneumothorax
- Pulmonary embolism
- Respiratory failure
- Anaphylaxis
- Cardiogenic shock
- Hypovolemic shock (due to hemorrhage)
- Neurogenic shock
- Obstructive shock (e.g., massive pulmonary embolism or Cardiac tamponade)
- Septic shock
- Ectopic pregnancy
- Eclampsia
- Fetal distress
- Obstetrical hemorrhage
- Placental abruption
- Prolapsed cord
- Puerperal sepsis
- Shoulder dystocia
- Uterine rupture
Urological, andrological, and gynecologic
- Ovarian torsion
- Gynecologic hemorrhage
- Paraphimosis
- Priapism
- Sexual assault (rape)
- Testicular torsion
- Urinary retention
| The basis of this article is contributed from Wikipedia.Org. These articles are licensed under the GNU Free Documentation License It may have since been edited beyond all recognition. But we thank Wikipedia for allowing its use.
Please discuss further on the talk page.
0 comments [hide]Post comment Options
Page ✜ Discussion ✜ Edit Page ✜ History


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Winter Moon of the Long Nights
Bone broth still gently boiling on the stove. Its been there since yesterday afternoon at 5 pm. First time I've made this. At 8 or so this morning I'm going to start a beef stew in the slow cooker. Beer is one ingredient so Kate bought a six pack of Dos Equis. Sacrificing for the cause.
Our very stable genius has just cavalierly unmoored the lives of 200,000 Salvadorans. That's a small city of immigrants. Lack of empathy is a hallmark of this administration, necessary for gutting the future with one trillion dollars plus in tax cuts, pretending that climate change is a liberal conspiracy, trying to dump transgender military personnel over supposed medical costs, and elevating pedophiles and other sexual predators.
In the debate over his mental illness I'm agnostic, agreeing with those who say he's obviously dysfunctional, yet unwilling to ascribe his character flaws to a particular diagnosis. It does a disservice to all people with mental illness when such a man, a man whose moral compass has been rendered useless by the powerful magnets of fame and money, is seen to act as he does because of possible narcissism or whatever else others find in his public persona. They may play a role, yes, but there are still underlying values toward which this particular man gravitates, values inculcated by a racist father and a distant mother, values embraced by a hollow man needing to fill a vast internal vacuum.
Nixon and Trump, cancers of the U.S. political system.
Sad about Rigel. A sort of dark blanket over our lives right now. There's a bit of hope that we'll find something other than cancer, but it seems slim. We want to know her prognosis, how best to care for her right now. She's a sweet, sweet dog.


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Marteen Releases 'We Cool' Music Video - Watch Now!
Marteen looks too cool in the "We Cool" music video, which you can watch right here!
The 16-year-old R&B-pop singer shared the fun new video for his single on Wednesday (December 6), which was shot as a single take.
PHOTOS: Check out the latest pics of Marteen
The awesome, uplifting video also features Marteen's real life friends and family from the Bay Area as extras.
Marteen recently wrapped up touring with Dua Lipa, and is joining Kehlani on her Tsnmi Christmas Tour beginning on Friday (December 8) in his hometown of Oakland, Calif.
Watch the "We Cool" video below!


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Has been the motto of the week.
We make anything out of anything
With some glue and a little tweak.
We had some fun planting mystery seeds.
The compost made us mucky.
We were given lots of bottles (recycled to make plant pots)
Aren't we lucky!
We watched a dustbin lorry
Munching rubbish in the rain.
We promised to reduce the load
before they came again.But take care with all the seeds inside(They won't agree with our inside;So keep them safely locked inside)Then we can rattle to our heart's content. In an Enrichment week…These are just a fewOf the amazing things we do.Hope you enjoyed it too!!


text: After last week's episode of the Great British Bake Off I decided to end my GBBO challenge and instead return to baking things I actually enjoy. I had my eye on a recipe the last few weeks that I couldn't wait to try and thankfully I had the opportunity to bake it on Friday when I was going to a family dinner. I had spotted this particular meringue cake in this years Christmas Good Housekeeping magazine and it seemed easy enough and it looked delicious too. Continue reading "Meringue Cake"


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Nourish: The 4th Annual Wellness Conference at YIS
We would like to invite all parents, teachers and staff to attend Nourish: The 4th Annual Wellness Conference at YIS. The theme of this year's conference is Living and Flowing with Emotion: How do we keep in balance?
The conference will take place at YIS on Saturday 20 February, from 9:00 a.m to 1:00 p.m., in the Loft and classrooms in the Main Building. This is a very special event with different kinds of talks and activities; we do hope you will join us for ideas for yourself and your children.
9:00 - 9:20 ~ Opening Activity with Adam Clark
9:25 - 10:00 ~ Short Talks with Ingrid Rossing, Destiny Ishihara, Michelle Trefren
10:15 - 11:15 Session 1 ~ Keynote Talk by Sara Hitchens: A Balancing Act: Thinking ourselves into well-being
11:30 - 12:30 Session 2 ~ Workshops with Damien Pitter, Michelle Trefren, Monna McDiarmid and Adam Clark {Please see descriptions below}
12:30 - 1:00 ~ Closing Session: Small Group Discussions regarding learning/take-aways
Our keynote speaker is Sara Hitchens, a UK-trained counsellor and psychotherapist, currently working in Tokyo in private practice and at two international schools. She is an Accredited member of the British Association of Counselling and Psychotherapy and a Board Member of International Mental Health Professionals Japan. Sara has lived and worked internationally, in Spain, France, Pakistan and previously in Tokyo from 1985-89. This has given her personal experience of the nomadic lifestyle, and an interest in cross-cultural issues. Sara says her greatest challenge to date has been mothering her two children, now aged 24 and 22.
Website: http://www.sarahitchens.
Workshop Descriptions:
Monna McDiarmid
The Art of Noticing: A Writing Workshop
It's easy to believe that creative writing is the exclusive realm of professional writers and children. That's just not the case. This workshop will give you an opportunity to nourish yourself by writing creatively, noticing the small, lovely details of your life and by practicing gratitude. You will have an opportunity to share if you'd like. No writing experience is required.
Michelle Trefren
The Voice and Mind Interchange: How vocal/singing techniques can bring out the best in you.
Our voice, an oral medium for expression directly linked to our thoughts, is the most personal instrument we can employ. In this session, you will learn vocal techniques through singing and song that connect the mind and voice. Discover your true voice and how it can help you express your thoughts.
Adam Clark
What are the issues facing adolescents now and what do we do to help?
This workshop is intended for parents and educators who want to discuss and learn more about the current issues facing adolescents. A group of grade 9 student presenters are also planning on attending to share their thoughts on what's happening and what adults could do to help. Topics discussed will include: self-harm/self-injury, coping, stress management, teen depression, suicide, social networking, gaming, and how change occurs. Obviously, because of the time limit, we will barely scratch the surface of these topics but this will serve as a good overview of some of the concerns and strategies for helping.
Damien Pitter
Picture This: A Photography Workshop
We use photographs for many purposes - as historical record, as expression, as a way of noticing. This workshop will introduce a few tips for taking better photographs of the people in your life and of your travels. We will also look at a simple, online image editing tool that can help you be more expressive with your images. Bring a fancy camera or your iPhone. Laptop optional.
To register, please complete the form below or email Ms. Irina Bryan at email@example.com by Thursday 18 February. We look forward to seeing you at Nourish on Saturday 20th February.
The Nourish Committee
Eliza Kumamoto, Damien Pitter, Irina Bryan, Adam Clark and Monna McDiarmid


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Free summer lunch program offered at MCS
Congratulations to the Class of 2016
Mollie Burgett honored with Excellence in Teaching Award
Class of 2016 holds Senior Breakfast event
Sixth-grade students prepare to move up to the Junior/Senior High School
Mollie Burgett honored with Excellence in Teaching Award
Kindergartners celebrated at Promotion Ceremony
Counselors' Corner: June 2016
High school and elementary students meet for Creek Day experience
Junior high student-athletes awarded for sportsmanship
The Class of 2016 plans for the future
Student-athletes celebrated for achievements
Delectable, eye-catching final from the Food Exploration class
Elementary classes immersed in spring lessons on history, science
Wall at MCS honors military service from district
Class of 2019 fundraises for Marathon for a Better Life
AP Environmental Science students test Schoharie Creek
Students collaborate with visiting artist and educator
Emergency preparedness training scheduled for June 13
Cupcake party held for sixth-grade honors students
2016 Valedictorian, Salutatorian and Honor Graduate named
Investigators at Middleburgh Jr./Sr. High School
Voters approve budget, bus proposition, elect two to BOE
Awareness Day teaches students about safe, healthy decisions
MCS to hold June 2 surplus auction of items and equipment
Residents to vote May 17 on proposed $21.3 million school budget
Counselors' Corner: May 2016
Meet the 2016-17 Board of Education candidates
SAT, ACT registration deadlines on May 5, 6
MES students recognized for leadership in physical education
Kindergarten Orientation, Screening scheduled for May, June
Woodcarving art and safety featured at MES Morning Program
Career and leadership skills developed in student-run company
BOE member Michael L. Fisher IV resigns
MCS Board of Education approves proposed budget
MCS bowlers honored by Board of Education
Tenth-grade students to explore careers through ASVAB
UHS Agricultural Business students visit SUNY Cobleskill
Student-run company selling stocks
MCS proudly inducts new Honor Society members
2016-17 state budget approved, sees increase in Foundation Aid
MES celebrates "Kids with Character" for March
MES morning program wraps up an exciting month
Support Sunship Earth through recycling
Prepare for the Super Bowl with SADD
MCS Spelling Bee 2016
BOCES Career and Technical Education Center to hold open house
Health class learns the consequences of impaired driving
Stay up-to-date with the MCS district mobile app
High school art class and Liberty Partnership welcome visitor
Class of 2016 hosts Jr./Sr. High School Penny War
Middleburgh students combat tobacco marketing
Music students participate in Area All State Festival
Families and MCS students celebrate an early Thanksgiving feast
MCS Elementary class creates "bee" quilt
Little Knights collect candy for overseas troops
Seventh grade Spanish class makes gazpacho
Hudson River Snapshot Day with AP Environmental Science students
Twin Day celebrated at Middleburgh Elementary School
Kindergarten and Grade 4 students visit Cooperstown's Farmer's Museum
AP Environmental Science students attend "Watershed Field Days"
Students chosen for Honors music
Elementary school students begin their school year
Junior and senior high school students begin their school year
Spanish Club takes summer trip to Felipe Carrillo Puerto, Mexico
Welcome Back Newsletter
Free and Reduced Lunch application for 2015-16
Kim Ross named interim principal at Middleburgh Elementary School
Middleburgh participates in Capital Region BOCES Summer Program
Changes to immunization requirements for 2015-16 school year


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Certified Nursing Assistant
A certified nursing assistant aka. "CNA" helps patients and clients with health care needs, under the supervision of a Registered Nurse (RN) and Licensed Practical Nurse (LPN).A certified nursing assistant — also referred to as a "Nursing Assistant," "Patient Care Assistant" and "State-Tested Nurse Aid" — serve an important role in the healthcare industry.The main difference between CNA and other nursing fields is the extensive, medical experience required of higher-ranking positions. CNAs are legally-restricted from performing certain procedures that call for additional training and credentials.
Registered Nurse,Licensed Practical Nurse, health-related specialties


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Crumbly Cranberry-Almond Biscotti
Shaped like biscotti, these omega-3-packed treats crumble like cookies:
1 cup oat flour*
1 cup whole wheat pastry flour
1 cup white whole wheat flour or all-purpose flour
1/4 cup almond meal**
3/4 cup natural cane sugar
1 tsp baking powder
1 tsp ground cinnamon
1/2 tsp sea salt
3 omega-3-enriched eggs
1 cup canola oil
1 tsp pure vanilla extract
1 tsp almond extract
3/4 cup chopped toasted almonds
1/2 cup sweetened, dried cranberries
1. Preheat oven to 350F. Line baking sheet with aluminum foil and coat lightly with oil. Set aside.
2. Combine flours, almond meal, sugar, baking powder, cinnamon, and salt in large bowl.
3. Whisk eggs, oil, and vanilla and almond extracts in small bowl.
4. Make a well in center of flour mixture. Add egg mixture and mix until just combined. Stir in cranberries and almonds.
5. Place dough on prepared baking sheet and shape into a flat loaf using hands. Bake until light brown, about 30 minutes. Remove from oven and let cool slightly.
6. Use a serrated knife to cut loaf into 1/2″-thick slices, cutting longer pieces in half. Lay flat on baking sheet and bake, in batches, 10 minutes, or until lightly browned.
Makes 2 dozen pieces (halved)
Per piece: 210 cal, 4 g pro, 20 carb, 2 g fiber, 13.5 g fat, 1.5 g sat fat, 27 mg chol, 8 g sugars
*Make your own oat flour using old-fashioned oats in a food processor.
**Make your own almond meal using raw almonds in a food processor.
–Recipe inspired from Organic and Chic by Sarah Magid.


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Sunday, June 12, 2016
Vacation at the Outer Banks!
8 comments:
Looks like a wonderful vacation, Maria! So fun to see pictures--almost feels like I've been there! The horses are amazing--never knew about them!ReplyDelete
Oh what lovely photos ... those horses are magnificent! Thank you for sharing!ReplyDelete
It looks like you had a fabulous time Maria! Thanks for sharing your lovely photo's :-)ReplyDelete
What a wonderful vacation! I love bed and breakfasts. That sunset is gorgeous!ReplyDelete
Ahhh, what a blissful week! I do so love the North Carolina coast! Thanks for sharing your beautiful photos, Maria! It's almost as good as being there in person! :DReplyDelete
Sounds like such a lovely vacation! I can't believe wild horses on the beach! Wow how lucky!ReplyDelete
A piwcw of heaven on earth; and your photos are beautiful! Good to read you had a great vacation!ReplyDelete
Looks like an absolutely wonderful trip, Maria! Thanks for sharing all of your beautiful pics!ReplyDelete


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Monday, April 16, 2012
The NYC Apartment of a 20 Year Old
11 comments:
- AnonymousApril 16, 2012 at 9:04 AM
AGH! I'm googling this biotch. Just kidding I'm sure she is lovely...just a little jelly! xo ElizabethReplyDelete
Not real. I am the MOST jealous of this gorgeous space!ReplyDelete
soak it up sweetie, you prolly cant live like that once u move in with a dude! (i dont sound jealous, do i?)ReplyDelete
Um...so not fair !!!ReplyDelete
What? I know my apartment didn't look like that when I was 20 (and, ahem, it doesn't look like that now.) Color me ridiculously jealous!ReplyDelete
wow, great taste! that's one lucky lady!!ReplyDelete
This is such a great appartment!! Love it!ReplyDelete
I'd love you to check out my blog!
xoxo lorena
What?!?! She's 20?? I don't even want to mention what my apartment looked like (that I shared with 4 other girls) when I was 20. Let's just say it was slightly different ;)ReplyDelete
Oh my goodness what a fabulous apartment - I wish it was mine. My landlord would kill me if I even thought of painting the ugly walls. xoReplyDelete


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It's hard not to smile when looking at that little face! I hope your 4th of July was as exciting as mine. I grew up loving the holiday and now I have a true appreciation for it. It's a great way for family and friends to get together and mingle. If you know me, you know I love to mingle!
I went a little overboard with making goodies for the holiday. I got really excited about dipping things in chocolate and using food coloring to dye things red, white, and blue!
First, I cheated. I have never been able to successfully melt chocolate without burning everything in site. So, I bought this:
....and holy smokes! IT WAS AMAZING! It cut down on my frustration level completely and it tasted yummy.
First, I snagged Martha's idea and made Pretzel Sparklers and they were delicious and super simple.
|Kudos, Martha!
After a few minutes of practicing our colors, I had a bowl full of red and blue M&M's to decorate my rice krispies.
|snap, crackle, POP!
The trick to my rice krispie treats is less KRISPIE! I don't put in the full 6 cups of cereal that the recipe calls for. That way, they are more gooey when you eat them. My tip comes with a warning though: once I thought it would be a good idea to use food coloring to dye my treats another color for Valentine's Day. Of course, I picked the color of l-o-v-e: red. Do you know what rice krispie treats look like when they are dyed red?
Raw meat. It was difficult trying to convince people to eat my snack when they thought I had brought raw meat to our food share! Be cautious of what color you dye your treats!
The food I posted today is so easy... your 5 year old cousin could make it. Really, famous chefs would probably laugh at this post because of its simplistic features! Oh-well.. they tasted yummy and were stress free!
Enjoy a picture of my pooch, Alex.
As Tigger would say... TTFN!


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Pray For Me
We believe that there is no greater help than the help we can find in prayer. Prayer is a powerful and vital discipline in our spiritual lives and intercession (praying for someone else) is a great honor and act of love that we can extend to one another.
King Street is a church full of people committed to prayer and we want to show God's love to you by being available in your time of need. We invite you to share your prayer requests with our pastoral staff and prayer teams at King Street. Email email@example.com or use the form below any time of the day or night. As those requests are received, you can have the assurance that we are interceding for you. Let us know specifically if you would like your need to be included in our printed weekly prayer guide.
Please feel free to use that same contact to send us reports of how God has answered your prayer so that we can rejoice with you.