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- German Courses
- Overview
- Current Courses
- German as a second language
- University of Applied Sciences, Bremen
- Bremerhaven University of Applied Sciences
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- University of the Arts Bremen
- Intensive Courses / TestDaF Courses
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Suchen und finden
Overview German Courses
German courses
The Goethe-Institut offers German courses for international students and scholars. Learning objectives will be adapted to the needs of the learners in the group.
Alongside these courses, you may also use the mediothek in the self access centre.
Prospective international students have the opportunity to participate in intensive courses to prepare for the TestDaF exam.
Please note that before you sign up for a course you need to provide proof that you language skills are at an appropriate level. Here you can find more information about the placement tests.
For more information on courses (times, costs..) contact the Goethe-Institut Bremen or the International Office.

subset: commoncrawl


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MOULTON, Ala. — A special-needs student had a one-of-a-kind prom date when an NFL player returned to his home county in Alabama to take her to the dance.
Don Jones is a 27-year-old defensive back for the San Francisco 49ers who is from Lawrence County. He tells WBRC-TV it was a "blessing" to go to the prom Friday night with 18-year-old Lindsey Preston, who has Down syndrome.
Jones is a family friend. His mother taught Preston in elementary school.
Preston's mom, Kristi Martin, tells The Associated Press that Jones danced with all the students and "made everybody feel special."
Jones played at Arkansas State before going pro. He has played for the Miami Dolphins, New England Patriots, New Orleans Saints, Cleveland Browns and Houston Texans.
StarTribune.com welcomes and encourages readers to comment and engage in substantive, mutually respectful exchanges over news topics. Commenters must follow our Terms of Use.
- Keep it civil and stay on topic.
- No profanity, vulgarity, racial slurs or personal attacks.
- Comments with web links are not permitted.
- Comments that violate the above will be removed. Repeat violators may lose their commenting privileges on StarTribune.com.
Comments will be reviewed before being published.


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It's Friday – how about some levity?
We live in a world where surveillance is everywhere. Municipalities have cameras on street corners. Banks are surrounded by cameras. University campuses are covered. Retailers are watching customers and employees. Indeed, thanks to the lowered price of surveillance solutions, a heightened need for surveillance and improved capabilities, we should never assume that our actions in public aren't being recorded.
Warning: Cute Videos Ahead


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New Step by Step Map For fema flood maps pinellas county florida
Leon says: May seventeen, 2012 at 7:01 am I've a 30K assert that was compensated through the insurance company and also the Verify was manufactured to me and to Financial institution of The united states. I hired an individual to do the work in my residence by which I sent the lender his w-9 and Legal responsibility insurance policy. He's not a certified GC but the one do the job remaining completed on the home after the certified plumber repaired the leak is changing drywall, tile, paint and Wooden flooring.
If there had been no twister and I made a decision to tear down my dwelling and Establish something more compact and fewer beneficial, assuming that I make my home loan payments what rights does my MC have? If they don't have any, why do they have rights after a disaster?
6. You refused around the ethical grounds that it was insurance coverage fraud which caused the purchaser to rescind their give.
2) The MC ought to have *NO* legal rights to income which has now been put in concerning some time of disaster and some time the adjuster has finished his function-up.
Think it over similar to this; if you were being self insured and all matters had been equivalent would you make the repairs now, or hold out until finally the task completes the necessity to get the job done by way of that place?
"It's an entire disaster and it'll take a lot of function to obtain Varadero again on its ft," reported Osmel de Armas, 53, an aquatic photographer who operates within the beach within the battered resort.
Make sure you Examine back again and allow me to and my visitors know the way items have turned out for you personally and share any recommendations You could have uncovered along how.
"The storm is right here," Florida's governor, informed a information conference, introducing that twenty five,000 persons had presently misplaced ability.The complete force with the hurricane just isn't envisioned until eventually Sunday with Florida's west coast set to facial area the worst battering with storm surges achieving 15 feet in look here destinations.
Ricardo Cobos - Raleigh Property finance loan Lender suggests: February 27, 2012 at eleven:55 am Cindy – It feels like you've got by now sought the advice of an attorney which is usually a very good first step! Regardless whether you are previous owing As well as in foreclosure, your mortgagee (Wells Fargo) has a moral and legal obligation to not impede the expedient maintenance of your home, having said that. You shouldn't count on your lender to generate the procedure straightforward or for them to release any of the surplus resources to you personally if the job is available in less than spending budget right until your home loan is paid existing, such as interest and fees.
Otherwise what am i able to do to obtain the Look at? When is often a assert deemed settled? How can he maintain our assert Check out and is he entitled to your post dated check for payment?
Finally this goes again to my initial argument – That is no unique than for those who experienced a claim against your vehicle coverage; your insurance company would make the Verify payable for you along with the financial institution when you had a loan and also the financial institution would want evidence The many do the job were finished (not simply Section of it) in advance of disbursing ANY this contact form of the cash to you personally or the human body shop. The one cause this differs is since many people In no way file a homeowners assert but We've got ALL experienced an vehicle assert.
It's the homeowners accountability initially and foremeots to safeguard Every person's curiosity like his lender. Thats what he agreed to when he borrowed the money. If he can't afford to buy th repairs away from pocket and wait to be reimbursed then he should decide on a contractor who can cash move The task.
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Articles tagged as: Indiana
December 18, 2015
Indiana's Unemployment Rate Holds Steady
Indiana's unemployment rate held steady for the third consecutive month in November, still its lowest level in 14 years.Read More
December 17, 2015
Indiana DHS Using Social Media To Warn Of Terror Threats
State officials say they will send out general information bulletins, as well as specific alerts when there is an elevated or imminent threat of a terror attack in the U.S.Read More
December 17, 2015
Pence Says 2015 Record-Breaking For Company Commitments
Gov. Mike Pence says 323 companies, up from 285 in 2014, pledged to create new jobs over the next few years.Read More
December 17, 2015
Indiana Expected To Collect Less Tax Revenue Over Next Two Years
The new revenue forecast includes optimistic expectations for individual income taxes, but, the outlook is significantly bleaker for sales taxes.Read More
December 16, 2015
Syrian Family At Home In Indiana
The first Syrian refugee family to resettle in Indianapolis has been here for over a year now.Read More
December 11, 2015
Indiana Ranks 41st In Overall Health For Third Year In A Row
That finding comes from the latest America's Health Rankings report from the United Health Foundation, and it's the third year in a row Indiana has landed in the exact same spot.Read More
December 9, 2015
Duke Energy Revamps Plan To Upgrade Aging Electrical Grid
Duke says its revised $1.83 billion plan complies with the Indiana Utility Regulatory Commission's request to explain its costs and confine modernization projects to its grid. But the consumer watchdog group Citizens Action Coalition says it will keep fighting the revised plan.Read More
December 9, 2015
Federal Funding To Prevent Teen Pregnancy May Not Survive Budget Battles
Teen pregnancy rates have dropped nationally, but in the small town of Frankfort, Indiana it's still a real risk. Teen pregnancy rates in Clinton County are three times the national average.Read More
December 9, 2015
Indiana Set To Kick Off Yearlong Bicentennial Celebration
An event scheduled for Friday at the Statehouse in downtown Indianapolis will feature the unveiling of an Olympic-style torch that will visit all 92 of the state's counties as part of bicentennial events.Read More
December 9, 2015
Indiana Prosecutors Push To Increase Penalties For Drug Dealers
The Indiana Prosecuting Attorneys Association wants to create a new crime: aggravated drug dealing. Offenders would receive harsher sentences under a variety of scenarios.Read More


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Mold Remediation: Techniques For Rookies
Mold can be observed almost anyplace. Under suitable circumstances, even so, it might turn into a fully propagate mold growth issue calling for mold remediation and cleanup.
The majority of the property owners observe staining on a wall that that looks like an old mold stain and they just overlook it. This is a bad idea as underneath it, an infestation might be hiding. It's typically a smart idea to call mold pros to perform a mold inspection and determine whether you have a mold situation in your house and the degree of it.
The terms "mold remediation", "mold removal" and "mold cleanup" are always used. While remediation can rid you of active mold, sometimes stains and staining continue on surfaces. If something like this actually happens, a mold cleaning is essential. Mold elimination is the method of normalizing mold air levels and reducing the presence of mold spores which can cause allergy symptoms.
Mold remediation Dallas professionals can actually handle everything. We will provide you some of the basic facts about mold formation, the signs that you must check and some assistance to make certain that you won't hire the wrong contractor.
Feel free to call us today for assistance on mold removal in Dallas.
The Basics Of Mold
Mold is one of the fungi kingdom or organisms and it is quite distinctive from plants since it doesn't need sunlight for photosynthesis. Ultraviolet rays can easily block its development.
There are 2 things that mold requires to develop - moisture and warm temperature. The spores are actually air-borne and they can be seen in the air around us. In order for the spores to turn problematic, they must be present in high volumes and experience favorable circumstances. As soon as the requirement for temperature, moisture and nutrients are pleased, mold can spread in about 48 hours. Ever since the 1970's, buildings are already made to be air-tight for energy conservation purposes. That also makes them susceptible to developing moisture-filled pockets that are suitable for breeding mold.
If you will see any indications of mold infestation, you must look for a professional mold remediation company quickly.
Different Signs That You Need A Mold Inspections
If a mold problem is already visible, it's clear you will need to hire experts to perform remediation and mold abatement. Nonetheless, the trouble with mold is that is sometimes continues to be hidden. Below you could find 7 signs which could mean you've got a hiding mold situation that requires your attention. Consider requesting a mold inspection, if any of the below apply to you.
1. Somebody in your household is encountering inexplicable allergic reactions for example runny nose, stuffy head, teary eyes, scratchy throat and headaches.
2. You discover stains on your walls and other surface areas that look like mold-spots but you are not totally positive they're.
3. There is actually a strong musty odor in your own home and the origin is unclear.
4. You experienced a leak or other water breakage in your house.
5. You want to confirm the air quality of your home after a previous mold remediation process and establish its effectiveness.
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A certified professional firm would absolutely need to do a comprehensive mold inspection before they could give you mold remediation and cleanup services. Call one the moment any of the above signs apply to your circumstances.
The Mold Remediation Process
If the result of the mold inspection performed in your house is positive, a mold remediation procedure will be done. You may wonder then what a good mold remediation method would involve. Although in some circumstances it might be possible for you to opt for DIY mold removal, it is best and generally safer to employ professionals to look after it.
There are eight important steps involved in mold remediation. First of all, it is important that appropriate protective wear is worn at all times, and that a full inspection was performed to identify the issue.
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Waste is then carefully disposed of, using the shortest route out of your home, and while eliminating the risk of cross-contamination, leakage, and breakage. Reliable remediators will be cleaning and sanitizing your belongings as well including curtains and other items.
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Do not fall prey to the lowest bidder, but seek out demonstrable cost-effectiveness.
Microscopic molds actually exist everywhere and you can't remove them completely. However, in scenarios of leaks, reduced ventilation of increased moisture, mold spores found in the air can flourish into full-fledged mold growth after as little as 48-72 hours. If you suspect you might have a mold situation, whether you could yet see it or not, contact qualified mold remediation Dallas specialists.
Mold growth can always be resolved, but you will have to give some thought to trained pros to make certain that the job could be completed properly.
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Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration
Received Date: May 22, 2018 / Accepted Date: Jun 11, 2018 / Published Date: Jun 13, 2018
Heat has been reported to exert variable effects on people with Gilles de la Tourette syndrome (TS). At age 24 years, a 32-year-old right-handed man with TS experienced a marked reduction in tics for two years after undergoing dehydration by entering a hot tub at 103°F (39.4°C) to 104°F (40.0°C) for 3 to 4 hours. On the Yale Global Tic Severity Scale (YGTSS) he scored 55 seven months before dehydration and 13 one month after dehydration. An intense heat exposure and dehydration led to an apparent remission in tics. The remission continued without the use of prescribed or nonprescribed medications or substances for two years until tics returned in the worst ever exacerbation after a tetanus immunization. The heat exposure may have altered at least temporarily his thermostat for normal heat-loss mechanisms through dopaminergic pathways from the anterior hypothalamus to the basal ganglia and the substantia nigra. Whether or not that mechanism or some other mechanism relevant to the heat exposure and/or dehydration is at play, the sudden and marked improvement in his tics needs further attention. Prospective testing of the heat and dehydration effect on tics should be pursued.
Keywords: Basal ganglia; Dopamine; Hypothalamus; Substantia nigra; Thermoregulation; Thermostat; Tics
Anecdotal reports of Gilles de la Tourette syndrome (TS) have suggested either improvement or worsening with heat [1]. Gilles de la Tourette himself reported that acute fever alleviated tics [1,2]. On the other hand, five of ten adult men with TS demonstrated prominent worsening of tics when the ambient temperature was increased from 22°C (71.6°F) to 35°C (95.0°F) [3]. Similarly, some people with autism, another developmental disability, demonstrate improvement of stereotypies and other movements with high temperature [4]. Reports on heat's effect on tics and stereotypies vary between improvement [1,2] and worsening [3] without reaching a clear consensus.
People with TS typically experience a decrement in tics with dopamine-receptor blocking drugs and an increment in tics from stimulants [1,3]. Release of dopamine in the preoptic area and the anterior hypothalamus plays a role in thermoregulation [3]. Although circuits for heat regulation may not overlap the circuits generating tics in TS, there may be indirect relationships between these circuits. Thus, the release of dopamine may play a role in mediating the effects of heat on tic intensity in people with TS [3].
There have been mixed reports on the rate of spontaneous remission in TS, as defined by greater than 10-point improvement the total score for tics (0-50) including both motor tics (0-25) and phonic tics (0-25) on the Yale Global Tic Severity Scale (YGTSS) [5]. Some investigators found a remission rate as low as 2/31 [6], while others reported somewhat higher rates [7-11]. When observed, spontaneous remission tends to occur at ages younger than the twenties, in patients who had shorter duration of illness, and with overall lower severity scores [12]. Based on the available literature on spontaneous remission, our patient, with moderately severe, long-standing TS in his mid-twenties, represents an exceedingly low probability for spontaneous remission.
Case Report
A young man participated in multiple assessments during research studies approved by the Institutional Review Board of the Johns Hopkins University School of Medicine, Baltimore, Maryland. He reported that he had induced dehydration several days after the episode without the consent or approval of the study physicians.
Clinical history
Since the age of 7 years, he experienced motor tics, including eye blinking, grimacing, and movements of head, shoulders, and fingers, and phonic tics, including grunting, snorting, and sniffing. Tics were exacerbated by cold, fatigue, and anxiety. Tics waxed and waned. Since childhood he experienced multiple tics simultaneously such as turning head to his shoulder along with a shoulder shrug.
Since the age of 10 years, he experienced recurrent episodes of 2 to 3 months of daily emesis occurring intermittently throughout the year alternating with complete resolution of the emesis for 2 to 3 months. Each episode of emesis was preceded by an uncontrollable sensation in his throat, a short premonitory awareness of a feeling that the food is going to regurgitate. The emesis occurred only when eating solid foods. Emesis fluid never contained bile or stomach contents. He experienced a sore throat when he had emesis. Emesis occurred after one or two bites of food or midway through each meal. He successfully resumed eating after completing the emesis. Antacids did not relieve the emesis. He undertook diets with foods of various textures without beneficial effects. The symptoms occurred only during eating. He had no other swallowing difficulty, no nausea, no abdominal pain, and no odynophagia.
He was unable to carry parcels with bottles for fear that they could be damaged if he experienced tics.
At age 22, trials of clonidine and topiramate produced minimal effect on tics.
At age 23, he began to occasionally smoke marijuana with relief of tics for 3 to 4 days.
At age 23 years, 5 months, he had his baseline evaluation. For the baseline evaluation please refer to Table 1 for objective assessments.
|Range of scores
|Six months before remission
|One month after remission
|Eleven months after remission
|Urine drug toxicology for tetrahydrocannabis
|Negative or positive
|Abnormal Involuntary Movement Scale (AIMS) [13-15]
|Clinical Global Impression (CGI) Severity Index (SI) [16]
|4 Moderately mentally ill
|3 Mildly ill
|2 Borderline mentally ill
|Clinical Global Impression (CGI) Global Improvement (GI) [16]
|4 No change
|2 Much improved
|1 Very much improved
|Clinical Global Impression (CGI) Efficacy Index (EI) [16]
|Clinical Global Impression (CGI) Therapeutic effect [16]
|Not applicable
|Unchanged or worse
|Unchanged or worse
|Clinical Global Impression (CGI) Side effects [16]
|Not applicable
|Clinical Global Impression (CGI) Attention Deficit Disorder (ADD) [17]
|1 Borderline
|1 Borderline
|Clinical Global Impression (CGI) Obsessive-Compulsive Disorder (OCD) [17]
|3 Moderate
|2 Mild
|Clinical Global Impression (CGI) Tourette syndrome (TS) [17]
|3 Moderate
|1 Borderline
|Clinical Global Improvement (CGI) Rater Global Evaluation (RGE) [18]
|4 Unchanged
|2 Much improved
|1 Very much improved
|Hillside Akathisia Scale (HAS) Subjective items [13,19]
|Hillside Akathisia Scale (HAS) Objective items [13,19]
|Hillside Akathisia Scale (HAS) Clinical Global Impression (CGI) Severity of Akathisia (SA) [13,19]
|3 Mildly akathisic
Normal, not akathisic
|1 Normal, not akathisic
|Hillside Akathisia Scale (HAS) Clinical Global Impression (CGI) Global Improvement (GI) [13,19]
|4 No change
|1 Very much improved
|1 Very much improved
|Magnetic resonance imaging of the brain [20, Table II, page 346]
|Normal or abnormal
|Maryland Psychiatric Research Center (MPRC) Brief Psychiatric Rating Scale (BPRS) Anchors [21-23]
|Movement Disorders Checklist [14]
|Myoclonus versus tic checklist [24]
|National Institutes of Mental Health (NIMH) Obsessive-Compulsive Scale (OCS) [18]
|Rating Scale for Acute Drug-Induced Akathisia (RSADIA) Subjective [25]
|Rating Scale for Acute Drug-Induced Akathisia (RSADIA) Objective [25]
|Rating Scale for Acute Drug-Induced Akathisia (RSADIA) Global Rating [25]
|Rating scale for drug-induced akathisia (RSDIA) Subjective [26]
|Rating scale for drug-induced akathisia (RSDIA) Objective [26]
|Rating scale for drug-induced akathisia (RSDIA) Global Clinical Assessment of Akathisia (GCAA) [26]
|Rating Scale for Tardive Dyskinesia (RSTD) Face [27]
|Rating Scale for Tardive Dyskinesia (RSTD) Neck and trunk [27]
|Rating Scale for Tardive Dyskinesia (RSTD) Extremities (upper) [27]
|Rating Scale for Tardive Dyskinesia (RSTD) Extremities (lower) [27]
|Rating Scale for Tardive Dyskinesia (RSTD) Entire body [27]
|Timed Stereotypies Rating Scale [14,28]
|Tourette Syndrome Diagnostic Confidence Index (TSDCI) [29]
|Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) [30,31]
|Obsessive-Compulsive Disorder through the application of the criteria current at the time of the study [32] to the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) [30,31]a
|Yale Global Tic Severity Scale (YGTSS) Motor [5]
|Yale Global Tic Severity Scale (YGTSS) Phonic [5]
|Yale Global Tic Severity Scale (YGTSS) Impairment [5]
Table 1: Objective assessments of a 25-year-old man 7 months before and 1 and 11 months after an almost full remission following dehydration in a hot tub at 103°F (39.4°C) to 104°F (40.0°C) for 3 to 4 hours (aObsessive-Compulsive Disorder (OCD) is diagnosed [32] if on the Y-BOCS [30,31] a person scores 2, 3, or 4 on any of the following items: 1 time spent on obsessions, or 2 interference from obsessions, or 3 distress of obsessions, or 6 time spent on compulsions, or 7 interference from compulsions, or 8 distress of compulsions).
Family history
His mother has TS. His sister has obsessive-compulsive disorder. He is married with one child. At age 3 and a half years, his 5-year-old son began to display motor tics, including eye blinks and simultaneous head movements to the shoulder along with shoulder shrugs, and a phonic tic, exaggerated coughing, similar to the proband.
Other histories
His past medical, surgical, social, developmental, and family histories and his review of symptoms were otherwise noncontributory.
Clinical course
At the age of 24 years and one month, he deliberately induced dehydration by entering a hot tub of 103°F for 3 and a half hour. During the last one and a half hour in the tub, he noticed that his tics had subsided. He reported that his tics had not recurred. After leaving the hot tub, he vomited clear fluid. He drank water because he was thirsty. He then regurgitated the fluid. After leaving the tub he experienced cramps in his legs, arms, and neck. For two days after leaving the hot tub, his urine was pinkish orange. He felt weak for a couple of days after leaving the hot tub. A month after the dehydration, he scored 13 for motor tics, 0 for phonic tics, and 0 for impairment on the YGTSS [5].
Please refer to Table 1 for a record of the multiple assessments to document his improvement. He was able to work full time as a computer technician. He remained almost completely free of tics for 2 years after heat-induced dehydration. During this remission he denied the use of medications and substances without a prescription. Please refer to supplementary materials for video segments before and after his dehydration.
At the age of 27, he experienced the worst ever acute exacerbation of all tics for two weeks after a tetanus immunization. The tics gradually returned to a mild level. He did not use medications or cannabis.
At the age of 29, he began using Δ9-tetrahydrocannabinol (THC) as an inhaled vaper nightly. His tics remain at a mild level. He has emesis approximately every six months. He has no exacerbation of tics with cold. He works ten hour a day for two jobs. He readily carries stock including eggs to shelves for a job without problems.
At age 25, a young man with TS experienced an almost full remission of symptoms sustained for 18 months after undergoing a presumptive dehydration in a hot tub at 103°F (39.4°C) to 104°F (40°C) for 3 to 4 hours.
Cerebral hyperthermia results in an increased blow flow to the brain [33]. Heat exhaustion is a moderate illness resulting from depletion of water and salt associated with core body temperatures between 37°C and 40°C [34]. Heat produced alterations in both excitatory neurotransmitters, aspartate and glutamate, and inhibitory neurotransmitters, gamma-amino-butyric acid (GABA) and glycine [35]. Since dysfunction of the GABA-ergic system is a major effect of heat on the nervous system, the reduced inhibition resulting from damage to GABA neurotransmission may result in increased excitatory neurotransmission in response to heat [35].
Increased excitatory neurotransmission may stimulate further dopaminergic neurotransmission and may predispose a person to develop seizures [35]. Sustained excitatory neurotransmission may have produced a marked phasic increase in dopamine in our patient to result in a lasting effect on thermoregulation by the dopaminergic pathways from the anterior hypothalamus to the basal ganglia and the substantia nigra. Heat and/or dehydration may have led to tiny infarcts in our patient's dopaminergic pathways from the anterior hypothalamus to the basal ganglia and the substantia nigra. The hyperthermia experienced by this man may have reset his thermostat for normal heat-loss mechanisms through dopaminergic pathways from the anterior hypothalamus to the basal ganglia and the substantia nigra. Whether or not that mechanism or some other mechanism relevant to the heat exposure and/or dehydration is at play, the sudden and marked improvement in his tics needs further attention. Prospective testing of the heat and dehydration effect on tics should be pursued. Clinical trials of dehydration and heat on TS may prove beneficial. The patient has been informed that unsupervised selfinduced dehydration may result in serious morbidity and mortality; he has not repeated dehydration.
The patient has noted beneficial effects of tetrahydrocannabinol (THC). He daily utilizes an inhaled vapor of THC nightly. THC, an antagonist of the cannabinoid receptor, has been utilized as a treatment for a spectrum of neuropsychiatric disorders [36]. While acute administration of THC produces increased dopamine release, chronic use reduces dopaminergic neurotransmission [37]. The interactions of THC with the dopaminergic system are complex, and not completely elucidated, however few modes of interactions described result in decreased activity of the dopaminergic system such as: 1) in humans chronic cannabis intake reduces dopamine synthesis capacity in the striatum as seen in a positron emission tomography (PET) study with 18-F-DOPA [38], 2) dopamine release is blunted in chronic human cannabis users [39], and 3) dopamine transporter (DAT) density is reduced in chronic cannabis users as seen in the PET study with 11-C PE2I, a selective DAT radioligand [40].
Because it was postulated that hypersensitivity of dopamine receptors and/or hyperactivity of dopaminergic neurons underlay the pathophysiology of Tourette syndrome [41,42], decrease of dopaminergic tone due to THC effects might have beneficial effects on tics severity. A randomized, double-blind, placebo-controlled crossover single-dose trial of THC in 12 patients with TS demonstrated significant improvements of tics and obsessive-compulsive behaviors [43]. A randomized, double-blind, placebo-controlled clinical trial of THC in 24 patients with TS demonstrated a significant reduction in tics with THC [44]. Nevertheless, systematic reviews concluded that the evidence is insufficient to support the use of THC and other cannabinoids to treat tics and obsessive-compulsive behaviors in people with TS [45,46]. Clinical trials with of THC for TS incorporating monitoring of dopaminergic and cannabinoid neurotransmission are needed to determine if THC is effective for TS.
This case also illustrates retching and vomiting, rare manifestations of tics in TS [47,48].
A placebo effect cannot be excluded in this open label exposure. Although the patient repeatedly exhibited normal temperatures during his baseline evaluation six months before his remission, we lack measured temperatures after the exposure to the hot bath. Given the relatively common occurrence of spontaneous remission, one could make an argument that association between two relatively common occurrences, heat exposure and remission of TS may be somewhat difficult to establish, given the high likelihood of co-occurrence by simple chance. Although he denied recent use of marijuana at each assessment, he may have experienced an effect of prior use of cannabis and related agents containing tetrahydrocannabinol [49]. Nevertheless, the occurrence of heat exposure and remission of TS may be chance. Spontaneous remissions of TS typically occur in adolescence. This patient is older than the typical adolescent to undergo a remission of TS. This single case report does not establish a causal sequence between heat-induced dehydration and remission of TS.
Supplementary Materials
Video 1. Segment 1: A 24-year-old man is asked to stand still for 2 minutes. He exhibits many tics of his eyes, face, neck, and hands.
Video 1. Segment 2: Eighteen months later the 25-year-old man is asked to stand still for 2 minutes. This clip was taken 11 months after he apparently experienced dehydration by entering a hot tub at 103°F (39.4°C)-104°F (40.0°F) for 3 to 4 hours. Adventitious movements are minimal at this time.
This research was sponsored by the Tourette Association of America, the Brain and Behavior Research Foundation (NARSAD), the Essel Foundation, the National Institutes of Health (NIH) by Public Health Service Grant DA09482, a BriteStar Bridge Award of The Johns Hopkins University, the Intellectual & Developmental Disabilities Research Center (U54 HD079123) at the Kennedy Krieger Institute of Johns Hopkins Medical Institutions in Baltimore, Maryland, and the National Center for Research Resources of the NIH M01RR00052 (Clinical Research Unit).
This research was sponsored by the Tourette Association of America, Brain and Behavior Research Foundation (NARSAD), the Essel Foundation, a BriteStar Bridge Award of The Johns Hopkins University, the Intellectual & Developmental Disabilities Research Center (U54 HD079123) of the Kennedy Krieger Institute, Baltimore, Maryland, the National Institutes of Health (NIH) by Public Health Service Grant DA09482, and the National Center for Research Resources of the NIH M01RR00052 (Clinical Research Unit). Earlier versions of this study were presented at the 15th International Congress on Parkinson's Disease and Movement Disorders, Toronto, Canada, June 5-9, 2011 [50], and the 1st World Congress on Tourette Syndrome and Tic Disorders, London, UK, June 24-26, 2015 [51]. We received no funds for covering the costs to publish in open access.
Conflict of Interest
The authors declare no conflict of interest. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
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- Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, et al. (1989) The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 46: 1006-1011.
- American Psychiatric Association. (2000) Diagnostic and statistical manual of mental disorders, (4thedn), text revision (DSM-IV-TR™). American Psychiatric Association, Washington, DC, USA, 456-463.
- Kiyatkin EA (2004) Brain hyperthermia during physiological and pathological conditions: causes, mechanisms, and functional implications. Curr Neurovasc Res 1: 77-90.
- Yeo TP (2004) Heat stroke: a comprehensive review. AACN Clin Issues 25: 280-293.
- Wetsel WC (2011) Hyperthermic effects on behavior. Int J Hyperthermia 27: 353-373.
- Quezada J, Coffman KA (2018) Current approaches and new developments in the pharmacological management of Tourette syndrome. CNS Drugs 32: 33-45.
- Bloomfield MAP, Ashok AH, Volkow ND, Howes OD (2016) The effects of Δ9-tetrahydrocannabinol on the dopamine system. Nature 539: 369-377.
- Bloomfield MAP, Morgan CJ, Egerton A, Kapur S, Curran HV, et al. (2014) Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms. Biol Psychiatry 75: 470-478.
- Volkow ND, Wang GJ, Telang F, Fowler JS, Alexoff D, et al. (2014) Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity. Proc Natl Acad Sci USA 111: E3149-E3156.
- Leroy C, Karila L, Martino J-L, Lukasiewicz M, Duchesnay E, et al. (2012) Striatal and extrastriatal dopamine transporter in cannabis and tobacco addiction: a high-resolution PET study. Addict Biol 17: 981-990.
- Butler IJ, Koslow SH, Seifert WE Jr, Caprioli RM, Singer HS (1979) Biogenic amine metabolism in Tourette syndrome. Ann Neurol 6: 37-39.
- Singer HS, Butler IJ, Tune LE, Seifert WE Jr, Coyle JT (1982) Dopaminergic dsyfunction in Tourette syndrome. Ann Neurol 12: 361-366.
- Müller-Vahl KR, Schneider U, Koblenz A, Jöbges M, Kolbe H, et al. (2002) Treatment of Tourette's syndrome with Δ9-tetrahydrocannabinol: Pharmacopsychiatry 35: 57-61.
- Müller-Vahl KR, Schneider U, Prevedel H, Theloe K, Kolbe H, et al. (2003) Δ9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: A 6-week randomized trial. J Clin Psychiatry 64: 459-465.
- Curtis A, Clarke CE, Rickards HE. (2009) Cannabinoids for Tourette's syndrome. Cochrane Database Syst Rev 4: CD006565.
- Martino D, Pringsheim TM (2018) Tourette syndrome and other chronic tic disorders: an update on clinical management. Expert Rev Neurother 18: 125-137.
- Rickards H, Robertson MM (1997) Vomiting and retching in Gilles de la Tourette syndrome: a report of ten cases and a review of the literature. Mov Disord 12: 531-535.
- Robertson MM, Stern JS. (1998) Tic disorders: new developments in Tourette syndrome and related disorders. Curr Opin Neurol 11: 373-380.
- Kanann AS, Jakubovski E, Müller-Vahl K (2017) Significant tic reduction in an otherwise treatment-resistant patient with Gilles de la Tourette syndrome following treatment with nabiximols. Brain Sci 7: 47.
- Brasic JR, Mari Z, Raymont V, Condouris S, Wong DF (2011). Partial remission of Gilles de la Tourette syndrome in a 24-year-old man after heat-induced dehydration. Mov Disord 26: S368.
- Brasic J, Mari Z, Lerner A, Raymont V, Zaidi E, et al. (2015) Almost full remission of Tourette syndrome in a 25-year-old man after heat-induced dehydration. In 1st World Congress on Tourette Syndrome & Tic Disorders, London, UK pp: 38-44.
Citation: Brašic JR, Mari Z, Lerner A, Raymont V, Zaidi E, et al. (2018) Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. Int J Phys Med Rehabil 6: 472. DOI: 10.4172/2329-9096.1000472
Copyright: © 2018 Brašić JR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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A first in class ARNi (angiotensin receptor neprilysin inhibitor)
Sample solution is provided at 25 µL, 10mM.
Publications citing ApexBio Products
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Chemical structure
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|Cas No.
|Download SDF
|Canonical SMILES
|CCCCC(N([[email protected]@](C([O-])=O)([H])C(C)C)CC1=CC=C(C2=CC=CC=C2C3=N[N-]N=N3)C=C1)=O.CCOC([[email protected]](C[[email protected]@](/N=C([O-])/CCC([O-])=O)([H])CC4=CC=C(C5=CC=CC=C5)C=C4)([H])C)=O.[3Na+].[2.5H2O]
|≥45.05mg/mL in DMSO
|Store at -20°C
|Shipping Condition
|Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
|General tips
|For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
LCZ696 is a first in class ARNi (angiotensin receptor neprilysin inhibitor) comprising anionic moieties of AR valsartan and the neprilysin inhibitor prodrug AHU377 (1:1 ratio) for heart failure and hypertension.
The angiotensin receptors are G-protein-coupled receptors. They mediate the cardiovascular and other effects of angiotensin II which is a bioactive peptide of the renin–angiotensin system. Neprilysin is a neutral endopeptidase that degrades endogenous vasoactive peptides such as natriuretic peptides. Inhibition of neprilysin increases the natriuretic peptides concentration that contributed to cardiac, vascular and renal protection. [1]
In Sprague-Dawley rats, oral administration of LCZ696 led to a dose-dependent rise in immunoreactivity of atrial natriuretic peptide resulting from neprilysin inhibition. In hypertensive double transgenic rats, LCZ696 caused a dose-dependent and sustained reduction in mean arterial pressure. A healthy participants, a randomized, double-blind, placebo-controlled study confirmed that LCZ696 provided concurrent neprilysin inhibition and AT1 receptor blockade. LCZ696 was safe and well tolerated in human. [2] [3]
McMurray JJ, Packer M, Desai AS et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014 Sep 11;371(11):993-1004.
Gu J, Noe A, Chandra P, Al-Fayoumi S et al. Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi). J Clin Pharmacol. 2010 Apr;50(4):401-14.
Langenickel TH, Dole WP. Angiotensin receptor-neprilysin inhibition with LCZ696: a novel approach for the treatment of heart failure, Drug Discov Today: Ther Strategies (2014),


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DS has convinced me to let him get one months subscription to xbox gold. There is a games bundle now on offer with Xbox gold that he really wants. I don't mind him getting these games as it's a good offer but my question is this...if his subscription runs out and he has bought the games, will he lose the games after Xbox gold expires? I dont want to buy the games and find out you lose them if you don't have Xbox gold. Any help or advice greatly appreciated!
If it's Xbox 360 then I think you can keep the games but if on Xbox one then you need the subscription to continue using the games..
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Balaghat RSS pracharak beating: SIT records statements of accused cops' wives
The Special Investigation Team (SIT) is recording statements of wives of Balaghat and Baihar policemen, who had been booked on charge of attempting to kill a Rashtriya Swayamsevak Sangh (RSS) pracharak in the district on September 25.bhopal Updated: Dec 19, 2016 09:42 IST
The Special Investigation Team (SIT) is recording statements of wives of Balaghat and Baihar policemen, who had been booked on charge of attempting to kill a Rashtriya Swayamsevak Sangh (RSS) pracharak in the district on September 25.
The RSS pracharak, Suresh Yadav, was allegedly beaten up in custody by seven policemen and two home guards over posting of an objectionable WhatsApp post.
On Thursday, the SIT team in Jabalpur recorded the statements of Zeba, the wife of Baihar police station in-charge Ziya-ul-Haq. Ziya is one of the seven policemen and two home guards who were suspended by the state government following protests by the ruling BJP's ideological mentor RSS.
According to SIT sources, Zeba's statements were recorded following her application to state's director general of police Rishi Shukla on October 5 seeking justice for her husband in the matter.
SIT sources said Zeba's detailed statements about the series of incidents in Baihar town on September 25 evening were recorded for an hour. Zeba told the SIT that her husband and other cops were falsely implicated in the case.
She also told the investigators that around 50 from a large mob that had encircled the Baihar police station that night had entered the adjoining police colony and approached towards their house in search of her and two little daughters. Fearing for life, she along with two daughters left Baihar for safer destination the next morning.
The SIT is probing all the four cases lodged at the Baihar police station on September 25-26, including the two cases registered against the cops-home guards and two lodged against unidentified protestors for attacking on duty cops and their vehicles.
Similarly, statements of Rekha, the wife of another accused and suspended cop, assistant sub inspector Suresh Vijaywar, have been recorded by the SIT members at a guest house in Balaghat a few days back.
None of the suspended cops or sacked home guards, however, has been arrested. Some of them, including additional superintendent of police Rajesh Sharma, have sought anticipatory bail from the Madhya Pradesh high court.
Importantly, four ruling BJP MLAs led by Waraseoni (Balaghat) legislator Yogendra Nirmal had sought a call attention motion in the state assembly's winter session over the delay in arrest of the accused policemen. But, the call attention motion didn't happen.
First Published: Dec 19, 2016 09:42 IST


text: Back to Results Listed Building The only legal part of the listing is the address/name of site. Addresses and building names may have changed since the date of listing – see 'About Listed Buildings' below for more information. 27-29 (ODD NOS) DUNDONALD ROAD, ST LUKES GREEK ORTHODOX CATHEDRALLB32508 Status: Designated Jump To: Documents Summary Description Statement References About Images Documents There are no additional online documents for this record. Summary CategoryB Date Added15/12/1970 Local AuthorityGlasgow Planning AuthorityGlasgow BurghGlasgow NGRNS 56281 67493 Coordinates256281, 667493 Description James Sellars, architect; 1876-77. Apsidal church in Normandy Gothic style, orientated North/South. Stugged coursed ashlar with polished margins and dressings. Main N facade with 90ft high heavily buttressed gable.At ground level, 3 pairs of pointed-arch windows with colonnette mullions; above 3 tall lancets with 2 orders of nook shafts, blind arcade links buttresses below gable head, latter flanked by octagonal pinnnacles and enclosing a rose window. To the right, steps to simply decorated pointed arch portal with band of foliate carving. Above rises transcept-like tower containing gallery stair. Aisles with four 3-light clerestory windows. Slate roofs.Interior: some recent minor modifications in accordance with Greek Orthodox worship, but with many original features. 4 arch arcade supported on octagonal columns. Gallery to N supported on brackets with panelled front. Apse to S containing organ; modern Byzantine screen of 5 pendant arches with icons incorporating part of the original screen asbalustrading. Carved octagonal timber pulpit. Stained glass by Stephen Adam, 1877. Timber lined collar-beam roof. Hall and vestry to east. Statement of Special Interest Ecclesiastical building in use as such. Formerly Belhaven UP Church.CHANGE OF CATEGORY; B FOR GROUP TO B 28-7-87. References Bibliography Gomme and Walker; 1968 p175. Information by courtesy of the Buildings of Scotland Research Unit. About Listed Buildings Listing is the way that a building or structure of special architectural or historic interest is recognised by law through the Planning (Listed Buildings and Conservation Areas) (Scotland) Act 1997. We list buildings of special architectural or historic interest using the criteria published in the Historic Environment Scotland Policy Statement. The information in the listed building record gives an indication of the special architectural or historic interest of the listed building(s). It is not a definitive historical account or a complete description of the building(s). The format of the listed building record has changed over time. Earlier records may be brief and some information will not have been recorded. The only legal part of the listing is the address/name of site. Addresses and building names may have changed since the date of listing and if a number or name is missing from a listing address it may still be listed. Listing covers both the exterior and the interior and any object or structure fixed to the building. Listing can also cover structures not physically attached but which are part of the curtilage of the building, such as boundary walls, gates, gatepiers, ancillary buildings etc. The planning authority is responsible for advising on what is covered by the listing including the curtilage of a listed building. Since 1 October 2015 we have been able to exclude items from a listing. If part of a building is not listed, it will say that it is excluded in the statutory address and in the statement of special interest in the listed building record. The statement will use the word 'excluding' and quote the relevant section of the Historic Environment Scotland Act 2014. Some earlier listed building records may use the word 'excluding', but if the Act is not quoted, the record has not been revised to reflect current legislation. If you want to alter, extend or demolish a listed building you need to contact your planning authority to see if you need listed building consent. The planning authority advises on the need for listed building consent and they also decide what a listing covers. The planning authority is the main point of contact for all applications for listed building consent. Find out more about listing and our other designations at www.historicenvironment.scot/advice-and-support. You can contact us on 0131 668 8716 or at firstname.lastname@example.com. Images There are no images available for this record, you may want to check Canmore for images relating to 27-29 (ODD NOS) DUNDONALD ROAD, ST LUKES GREEK ORTHODOX CATHEDRAL There are no images available for this record. Search Canmore Printed: 16/01/2019 06:55


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Mary E Cox (1921 - 2008)
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Mary E Cox Biography & Family History
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|Vancouver, Clark County, Washington
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|Mary E Cox lived 17 years longer than the average Cox family member when she died at the age of 87.
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1921 - In the year that Mary E Cox was born, hugely popular Roscoe "Fatty" Arbuckle, silent film star, was arrested for rape and manslaughter after an actress died following a party at his house. He was acquitted after three trials and the jury wrote a formal letter apologizing for the charges, but his career never recovered. His films were at first banned - the ban was lifted after a year - and he was mostly ostracized by the community. He died at 46..
1931 - Mary was only 10 years old when in March, "The Star Spangled Banner" officially became the national anthem by congressional resolution. Other songs had previously been used - among them, "My Country, 'Tis of Thee", "God Bless America", and "America the Beautiful". There was fierce debate about making "The Star Spangled Banner" the national anthem - Southerners and veterans organizations supported it, pacifists and educators opposed it.
1936 - Mary was merely 15 years old when on November 2nd, the British Broadcasting Corporation (BBC) debuted the world's first regular high-definition television service. The channel had a short schedule - Monday through Saturday, 3:00p to 4:00p and 9:00p to 10:00p. The first broadcast was "Opening of the BBC Television Service".
1961 - By the time she was 40 years old, on August 13th, East Germany began erection of what would become the Berlin Wall between East and West Berlin. In one day, they installed barbed wire entanglements and fences (called Barbed Wire Sunday in Germany). On August 17th, the first concrete elements and large blocks were put in place.
1989 - At the age of 68 years old, Mary was alive when on November 9th, the Berlin Wall fell. The Wall was built by the East Germans to keep East Berliners from escaping into West Berlin, separating families and friends. When the head of the East German Communist Party announced that day that East Berliners could cross whenever they pleased, happy crowds surged across the border. People brought tools and took parts of the hated wall.
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This obit of Mary E Cox is updated by the community. Edit this biography to contribute to her obituary. Include details such as cemetery, burial, newspaper obituary and grave or marker inscription if available.Mary E Cox died on April 1, 2008 at age 87. No cause of death has been entered. She was born on January 8, 1921. We are unaware of information about Mary's immediate family. We know that Mary E Cox had been residing in Vancouver, Clark County, Washington.
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- Samuel Cox (died 1965)
- Helen N Cox (1916 - 1995) Everett, Washington
- Jessie E Cox (1909 - 2002) Escondido, California
- Robert Cox (1924 - 1974) Tygh Valley, Oregon
- Georgia v Cox (1921 - 1997) Sedro Woolley, Washington
- Dorothy E Cox (1922 - 1989) Newport, Oregon
- Marvin Cox (1923 - 1978)
- Arlene L Cox (1927 - 2001) Denver, Colorado
- Bette S Cox (1924 - 1996) Deer Park, Washington
- Harry Cox (1884 - 1967) Spokane, Washington
- Elizabeth E Cox (1913 - 2009) Colville, Washington
- Marcia Cox (1911 - 1983) Spokane, Washington
- Marie Cecelia Cox (1914 - 2007) Lakewood, Washington
- Mabel M Cox (1905 - 1990) Slidell, Louisiana
- Grayce Cox (1907 - 1980) Spokane, Washington
- Callie Cox (1897 - 1982) Spokane, Washington
- Isla E Cox (1904 - 1991) Los Osos, California
- Thelma J Cox (1920 - 2001) Spokane, Washington
- Emogene E Cox (1910 - 1987) Port Angeles, Washington
- Marie Lucille Cox (1925 - 2009) Ferndale, California
Other Bios
- Robert Christiansen (1921 - 1984) Gig Harbor, Washington
- Edna B Herrman (1918 - 1990) Tacoma, Washington
- Clara G Anderson (1923 - 2004) Tacoma, Washington
- F H Mortensen (1917 - 1999) Eugene, Oregon
- William G Lundberg (1919 - 2004) Puyallup, Washington
- Virginia Szczepanski (1921 - 1987) Puyallup, Washington
- Mabel Dahl (1895 - 1976) Tacoma, Washington
- Laurel Covington (1897 - 1968) Spokane, Washington
- Geraldine F Schay (1923 - 2003) Bremerton, Washington
- Thorsten Andersen (1921 - 1990) Grayland, Washington
- Delno Rathburn (1921 - 1980)
- Orval Luther Jones (1917 - 1979) Milan, Illinois
- Norma M Kobata (1916 - 1995) Stratford, Washington
- Annabelle Carns (1892 - 1969) Hood River, Oregon
- Frank J Brennan (1922 - 1991) Mukilteo, Washington
- Edgar R Mullin (1922 - 2006) Pompano Beach, Florida
- Clarence Southard (1905 - 1972) Pendleton, Oregon
- Alfred Neff (1903 - 1970) Seattle, Washington
- Henry Barnes (1900 - 1973) San Jose, California
- Mary J Parker (1922 - 1997) Tacoma, Washington


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I am trying to get into my Creative Cloud account, but it says the server is down. When I click on the status link, it says it is functioning normally. But it is not functioning normally and I can't get into anything except this forum. I have a LOT of work to do, so I really need access to this account. I understand servers go down, but it has been 3.5 hours now and this is Adobe, not a mom and pop venture. Please help.
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What is the exact message are you getting? Are you only seeing the error on a specifc page?
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We have a two machine Filemaker 16 Server deployment and would like Filemaker clients to connect via the Worker hostname rather than directly to the Filemaker server hostname.
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We are setting up Filemaker 16 server for FMP (Filemaker clients) and custom web publishing (PHP) on two Windows server 2012 R2 (VMs) that are behind a load balancer. We do not use webdirect.
The hostname of the webserver is open to the public, and the webserver works well with Filemaker (we are using Let's Encrypt for the SSL certificate). The webserver (PHP code and IIS server) are on the Worker [rather than the FMS server (Master)].
We want only the worker machine to be public (open through the load balancer). We also prefer to use the worker SSL certificate for clients. We have admin access to the VM's but must ask the people responsible for the load balancer to setup forwarding/ports/firewalls etc. We will ask them what we need though. Currently the test setup works with clients connecting directly to the Master.
It is not live yet. Currently we are using a single older Mac mini, Filemaker 11 server, PHP & Apache- we updated all the PHP code to work in both environments so our transition is proceeding well.
Thanks in advance!


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This is a part time position, working at the Cranston location on Atwood Ave. The position is a 25 hour work week at $11.25 per hour.
Enterprise Rent-A-Car is the largest and fastest growing privately owned automotive rental and leasing company in the U.S.
The Service Agent cleans vehicles inside and out (vehicles may be cleaned by hand or by operating washing equipment). The Service Agent also performs regular maintenance (non-mechanical services), moves vehicles, and performs other duties assigned by the manager, all completed in a safe and timely manner.
The Service Agent Car Cleaner is responsible for the care and maintenance of the cars on the lot. This includes vacuuming and prepping the cars, shuttling cars to and from car washes and dealerships for servicing, car transports to and from offices, checking fluid levels, and changing tires.
Equal Opportunity Employer/Disability/Veterans