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Not known Details About ballet stretch band exercises
Pole dancing became my passion in 2011 and due to the fact then I've also created a like for flexibility education! I was not Normally bendy Once i commenced pole Health and fitness & Therefore the obsession with flexibility began! I hope to share my strategies and what I have uncovered through my journey with you guys!
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Taking the Stress Out Of Entertaining.
For our next Abbys Wine Tasting Evening, we will be sharing with our guests the wonderful taste of Spain.
You'll enjoy tasting four different Spanish wines with three delicious courses of food too.
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Days After First Chemotherapy – Reality and Realisms
This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The LungCancer.net team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.
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APPLE is gearing up for a brand new roster of smartphones, and we reckon we've got a good idea about what to expect from the iPhone 9. If you're desperate to know what's in store, read on for the latest news and rumours about the iPhone 9 release date, specs – and most importantly, price. iPhone 9 release date – when is the next iPhone out? It's very easy to guess the iPhone 9 release date, because Apple very rarely strays from its traditional launch pattern. Apple always announces a new iPhone in early September, typically on a Tuesday or Wednesday. That means we're most likely to see the iPhone 9 revealed on Tuesday, September 11, or Wednesday, September 12. For the actual release date, Apple tends to prefer a Friday in mid-September – usually around the 20th day of the month. This year, the most likely date seems to be Friday, September 21, so mark your calendars.iPhone 9 news and rumours – specs, features and design Detailed iPhone 9 leaks won't emerge for a … [Read more...] about iPhone 9 release date revealed? All the latest news and rumours about specs, price and more
Iphone 4 release date
Black Ops 4 release date revealed – all the Call of Duty 2018 news, rumours, leaks and more
CALL of Duty is officially set to return with Black Ops 4 in October this year. We've sniffed out the latest information about the Black Ops 4 release date, gameplay and more, so read on for all the news so far. Call of Duty 2018 release date – when is Black Ops 4 out? Activision has confirmed that Black Ops 4 will be unveiled on May 17, 2018. However, the global launch won't take place until October 12, 2018. Call of Duty 2018 news and rumours – where will it be set? Activision has three different studios working on Call of Duty at any one time. This lets the company keep up its blisteringly fast release pace of a new Call of Duty game per year. According to the schedule, that means Treyarch is the studio set to debut its top-secret shooter in 2018 – which is now confirmed. Call of Duty fans will know that Treyarch has been responsible for all of the Black Ops games to date. The first came out in 2010, followed by a sequel in 2012, and then another in 2015. And … [Read more...] about Black Ops 4 release date revealed – all the Call of Duty 2018 news, rumours, leaks and more
Comments for : Apple iPhone 5 release date to be September 21st?
posted on 22 Aug 2012, 02:13 12 1. Android4u (Posts: 456; Member since: 16 Aug 2012) I will never go back to apple and I expect it to at least be par to what high end android devices are. Bigger display, 4g lte, nfc, quad core maybe... 12mp maybe.... Bigger battery.. leaving anything out.? posted on 22 Aug 2012, 07:43 7 15. RealRapRaw (Posts: 10; Member since: 29 Dec 2011) You are leaving out the major selling point, which is the overall user experience. Having experienced all of the current mobile OS's, I see no utility to your argument against Apple based solely on specs. I am still thriving with my iPhone 4 with its 2010 era specs. Since I got the iPhone 4, I've also tried out the EVO 3D, Droid Bionic, Rezound, and the Galaxy Nexus during multiple trial periods for each device. Not one of those devices gave me at least what the iPhone 4 gives me, which is iOS. I've also tried the Lumia 900, which, save for LTE and a larger screen, proves that those bloated … [Read more...] about Comments for : Apple iPhone 5 release date to be September 21st?
Reminder: iOS 8.4 release date and time is today, June 30; update brings Apple Music to the iPhone and iPad
iPhone and iPad users, listen up, as we have a reminder for you. iOS 8.4 – the software update announced by Apple at WWDC 2015 – is almost ready to be released. In fact, it is to be rolled out in just a few short hours. As we reported a couple of days ago, the iOS 8.4 release date is today, June 30, and the update is scheduled to go live at 11:00AM Eastern time (10:00AM CDT / 9:00AM MDT / 8:00AM PDT). What should you expect the update to introduce? Well, let's start by saying that you're not getting the full feature set of iOS 9 yet. That's coming later this year. What iOS 8.4 does bring, however, is Apple's audio streaming service – Apple Music. Once signed up, you'll have access to millions of songs from popular (and not-so-popular) artists and bands. And if you don't know what to listen to, the Beats 1 live radio will be broadcasting the latest tunes for you 24/7. Apple Music will cost $9.99 per month with a 3-month free trial. You may still tune in to … [Read more...] about Reminder: iOS 8.4 release date and time is today, June 30; update brings Apple Music to the iPhone and iPad
Comments for : The iPhone 6s release date gets tipped by a Best Buy AppleCare leak
0. phoneArena posted on 17 Aug 2015, 09:23 Best Buy has apparently scored a big victory regarding the offering of Apple services, signing up for both the typical AppleCare protection plan for Macs, and AppleCare+ for iOS gear and the Apple Watch. That's not all there is to this bit of leaked news, though, as evidently Best Buy stores will start offering AppleCare at its stores starting the week of September 14th, which, coincidentally, is the expected week of the iPhone 6s release date... This is a discussion for a news. To read the whole news, click here posted on 17 Aug 2015, 11:00 0 1. Iodine (Posts: 1454; Member since: 19 Jun 2014) Really excited about all the upcoming innovations ! It's coming like an avalanche. posted on 17 Aug 2015, 11:29 0 2. Cheezwiz (Posts: 430; Member since: 29 Dec 2014) pouring like an avalanche, coming down the mountain? posted on 17 Aug 2015, 11:45 0 3. Metalspy8 (Posts: 77; Member since: 27 Feb 2012) iphone 6 plus s for the … [Read more...] about Comments for : The iPhone 6s release date gets tipped by a Best Buy AppleCare leak


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Social media is an awesome dating tool. Here is my Grindr profile. She also competed in the synchro springboard event at Worlds — she and Johnston placed ninth — but was unable to help secure an Olympic berth in that event for the U. Since year-olds routinely spout bullshit about things they know little about in an attempt to render a monolithic prescription regarding how one should live his or her life, it follows that Smith does this in regards to how one should be gay.
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He asked for shaming of the reporter as well as the olympic dating app for endangering people's lives at the village. You tell her to come to the hotel, she shows up with three dudes to rob you. Are you just an asshole like everyone else on here? No new notifications View all notifications Hey, click the icon to check the status of your contributions.
In the mountain village it's all athletes. The dating app company says there's been a 1, per cent increase in people changing their location to South Korea.
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In in Rio, a Brazilian newspaper reported that a record-breakingcondoms were given to athletes, about 40 per person. The members went on their separate ways when Jiyoon, Gayon, Sohyun and Jihyun decided not to renew their contract with Cube Entertainment in June Make sure your first pic is best!This promising pair took home the gold medal at the U Dating Ice Dancers.
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A new dating app has been created, but you can only use if you went to a private school.
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In this class, we will focus on joint mobility and awakening drills, specific core conditioning exercises and yoga flow, ending in some deep stretching. Personal mat required.
$12 drop-in ($5 for 7DDF participants)
Kate Stevenson received her BS in Exercise Science from Western in 2000 and has been a movement instructor ever since. With a rich background in dance, Kate emphasizes movement technique, rhythm, and joy in her classes. Kate holds the following certifications: NSCA - Certified Strength and Conditioning Specialist (CSCS), ACSM Heath/Fitness Instructor, Aerobics and Fitness Association Certified (AFAA), Polestar Pilates Instructor, and Clubbell Yoga.


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Ever heard of "The Football War"? In 1969 El Salvador and Honduras played each other in a play-off to decide who qualifed for the Mexico World Cup the following summer. A two leg match between the teams resulted in two home wins (back then aggregate scores weren't used) where the visiting sides were intimidated and threatened by home fans, while there were plenty of reports of attacks on Honduran citizens living in El Salvador and vice versa. In the end, El Salvador qualifed for the World Cup by winning a playoff after extra-time in Mexico, a neutral venue. But with this helping fuel extreme tensions between the two nations, the two countries were at arms within a fortnight. The war lasted only four days, but resulted in an estimated 4,000 deaths, population displacement on a horrific scale, and absolutely no benefit whatsoever to either country.
El Salvador didn't even get out of the group stage at the World Cup.
I was reminded of this in light of Hand of God II/Hand of Henry/Le Hand of God/whatever cheap play on words you prefer which refers to a combination of France, Thierry Henry, and the parallels with a certain Argentinian genius-turned-cheating scumbag, since, 24 hours later, it seems to be turning into a teensy bit of an international incident. I began fantasizing about an ultimatum from the Taoseach to the Elysees Palace, with the Irish demanding a replay of the match along with the immediate extradition of Monsieur Henry for execution (presumably by drowning him in Guinness). A refusal to comply could lead to an immediate air strike of Clover Bombs, an assault by an elite leprechaun commando unit, and chemical attacks on the French population through the poisoning of the snail and frog populace, and the destruction of their annual garlic crop.
But then I realized that, apart from the above daydream being hugely stereotypical, and also a bit racist, countries really have gone to war after football matches, and it is not really very funny after all.
But I digress, for the objective of this blogpost is to provide my tuppence worth on the Henry saga. And let's get an important thing out of the way first. If that had been a Scotsman who hand handballed, and the resultant goal had put us in the finals, we would have grinned awkwardly, looked a bit sheepish, and then demanded our place at the World Cup. Wouldn't we?
That doesn't mean that a storm shouldn't be rattled up over this, though. Henry himself hasn't done himself, France or the men in charge any favours by effectively admitting to deliberate handball. Instead of saying "It was accidental, honest", which would be awfully difficult to disprove, he has basically told the world "cheating is okay until it gets caught". That's a terrible thought at the best of times, but in a situation with such a profound outcome - financially as well as in terms of glory, it's downright scandalous. The world knows that Thierry Henry cheated, and that France have fraudulently earned a place in the World Cup at the expense of Ireland.
What will the fallout be? It's unlikely to be nuclear, simply because FIFA don't have the guts at the best of times and we all know, through their outrageous decision to seed the playoffs, that they were willing to do everything in their power to get France to South Africa. But it's nice, like with the recent diving episodes, that a storm is being cooked up, and that even French politicians are embarassed by it. But there's more chance of me getting a Scotland cap than there is of the Irish getting a second chance at qualification.
Anyway, I will now, like an awful lot of other fans, be adopting a support-anyone-against-France plan in June, and hoping that gallic luck deserts them next time. I wonder whether, today, Monsieur Henry woke up and thought "wish I'd let it go out for a goal kick and taken my chances in a shootout".
If only.


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The past three weeks have been the most demanding weeks for me. I wanted to quit too many times- I don't recognise this voice, but it kept telling me 'you can do this'.
There were many little things that became difficult and as usual I wanted to panic and just quit, but this new voice kept affirming inside my head, 'you can do this'.
I don't know who that voice was, but every time it said those words to me, I repeated them aloud, sometimes with tears in my eyes and I continued. Every time I continued I overcame the difficulty. And the more I won, the more I believe that I could.
There were various things that tried to get me to quit on them, but everyone of them I persisted on, I overcame. I started to wonder if really it meant that I could do anything as long as I believed I could.
It made me want to take on the world. I got a voracious appetite to do. I did more than I usually did. I took on more than I usually could deal with, and every time I faced stress I told myself now, You can do this, babe. And I always did it.
Who was that voice tho? And where did it come from? How come all these years I've never known it. It's so sad, Cos I've given up a lot in the past. If only this voice had been around all these years. Or maybe, if only I had believed it all these years.
Now that I have a relationship with this voice that pushes me to do the impossible,and now that I have proven that I can believe it, what does the future hold for us?
More than I can imagine.
The moment I proved that I could do anything I believed that I could do, I stepped into the realm of Possibilities only. I felt superhuman.
The way this thing works, I believe, is to stay calm, take a deep breath and make audible affirmations to yourself. Tell yourself who you are cos sometimes you forget. Say,
You can do this
You are strong
You are smart
You are a warrior
You are a king
You are fire
You are irresistible
You are indestructible
You are Life …
You go ahead and say it to you, until you believe it. Say it shaking, say it crying, say it when you're weak… ( Joel 3:10 Let the weak say,"I am Strong ") Say it.
I never knew I had a low self-image till I started to address myself.
At first, I couldn't look me in the eye and say, " you're beautiful" or "you're excellent" it felt weird. But then I realised it wasn't weird, it was a problem, I lacked a self-image.
I disregarded me. I let people regard me for me: when someone said I was beautiful then that was what I was, when they said I was intelligent, I was that. Of course sometimes they said bad things which I didn't always agree with, but the majority of what they said were positive so I took those along with the criticism they often gave along side their complements. Basically, I was perfect-flawed in my eyes.
No one would ever love you like you could. They would never see only the best in you. The same people that call you blessed today would inevitably see a fault in you tomorrow, that's what's wrong with letting others give you a picture of who you are.
So. I looked into the mirror for the first time, a whole minute; I looked into my eyes and I said, you are complete.
That did it for me. I broke the bondage of seeing myself through the eyes of others and finally that voice inside me was given the permission to tell me who I was and what I could do. That voice I had silenced for so long, by amplifying the voices of friends and family instead.
The voice of the greater one living inside of me.
Make a commitment today, to Love you fiercely. It's not being selfish. Don't wait for anyone to do it for you, honey. No one can everrr Love you like you can. In fact they will imitate the love you have for you.
The Love and sacrifice of Christ for us is our license to price ourselves highly.


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Drop The Knife & Save A Life
£485 of £3,000 goal
Raised by 18 people in 4 months
Campaign Website: www.droptheknife.com
1 knife attack every 16 minutes is happening on our streets today.
Knife Crime is the fastest growing killer of young people today... yet the government aren't acting. Instead, they have cut our policing budget by £700million, slashed our police force by 20,000 officers and reduced stop and search powers.
With gang culture being glorified and street violence on the rise, this epidemic is spreading, it's leaving more mothers to mourn their children and so much future potential wasted.
Drop The Knife is a knife crime awareness program aimed to drive AWARENESS and ACTION to reduce knife crime on our streets. Launched by ex Athlete - Will Flint after he fell victim to a horrific knife attack on New Years Day 2017.
Heading home from meeting friends on New Year's Day he stopped to use a cashpoint. Whilst there he witnessed a girl being assaulted by a man on the street.
Will intervened and when he did the man pulled out a kitchen knife started stabbed him continuously, leaving Will fighting for his life with 12 stab wounds; a punctured lung, paralysed diaphragm, severed spleen and lacerated stomach.
Will Flint: A year on from the incident I have made the decision to return to the bodybuilding stage and compete one last time. On Sunday 16th September, I'll be entering into a prestigious National Fitness Competition: PCA Men's Physique.
Throughout my recovery, I battled with a lot. Not just physical scars but mental ones too, the mental implications of violence are often the most permanent and crippling. Hopefully my journey can go some way to inspiring people that they can get back up and recover after a traumatic life-changing event.
This is why I've decided to raise money in partnership with multiple Knife Crime Prevention trusts to bring an innovative and effective program to UK schools, discouraging our youth from a life of violence and to BRING BACK THE FIGHT against knife crime: the fastest growing killer on our streets.
The money will be spent on educating young people on the effects of knife crime and the damage it causes to victims and their families. The program will be rolled out to local schools as an engaging seminar designed to leave a powerful impact on childrens' minds showing them the devastation carrying a knife can cause.
Please pledge your support by donating what you can afford... It's time for CHANGE!


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15 Story-Driven Games For Sharing With A Partner Or Friend - Kotaku Australia
Wolf Among Us has darker humour too, owing to the seedy nature of the Fables' retreat from their homelands. Tales From The Borderlands is much more slapstick, and consequently it might be more suited for only casual gamers or people who prefer their entertainment to be on the lighter side. You'll enjoy some of the jokes more if you're familiar with the Borderlands cast, but the game's perfectly enjoyable without it. 15 Story-Driven Games For Sharing With A Partner Or Friend - Kotaku Australia
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text: The Magic Voyage is a 1992 German animated fantasy film, released theatrically in Germany as Die Abenteuer von Pico und Columbus by Bavaria Film in 14 February 1992. The film was later dubbed in English and released in the United States and Canada. Two English dubs were actually produced. The first one was a rare English dub, while the second English dub was released by Hemdale Film Corporation as The Magic Voyage on 25 April 1993 with a new and more well-known voice cast. Both English versions also had different music soundtracks and different translations. It was produced and directed by Michael Schoemann. ... more on Wikipedia


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School Council
Our School Council is elected by the pupils and consists of a boy and a girl from each of the year groups 1 to 6. It meets regularly with the Head Teacher to discuss matters of interest to the children. Representatives are also invited to attend one staff meeting a term to discuss the ideas they have generated.
This year our school council is:
Year 1 Lily and Kaileb
Year 2 Jessica and Hayden
Year 3 Thomas and Eva
Year 4 Bella and Wesley
Year 5 Roxy and Tai
Year 6 Imogen and Jayden
Update: Term 2
School council have organised a bake sale as part of our children in need day. They organised the donations and selling of cakes and in total raised well over £100. You did a fantastic Job School Council! Later in the term the school council will be visiting local care homes to perform Christmas carols - Mrs Foord.


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JACKSON — School teachers would get debit cards to buy classroom supplies under a money-saving measure moving forward in the state Senate.
A bill approved yesterday by the Senate Education Committee mandates that districts use debit cards for employees' travel and classroom supply purchases. It also calls for districts to pay employees only once a month and to stop issuing paper paychecks.
A report projects the supply money changes could save more than $8 million.
A larger efficiency bill that would require school districts in each county to consolidate back-office services, a priority of Gov. Phil Bryant, may be stalling.
Bryant's push for county-level consolidation is facing doubts. A House Education subcommittee tabled a bill yesterday, and the Senate has yet to take it up.
The bill is Senate Bill 2761.
… we'd like to ask for your support. More people are reading the Mississippi Business Journal than ever before, but advertising revenues for all conventional media are falling fast. Unlike many, we do not use a pay wall, because we want to continue providing Mississippi's most comprehensive business news each and every day. But that takes time, money and hard work. We do it because it is important to us … and equally important to you, if you value the flow of trustworthy news and information which have always kept America strong and free for more than 200 years.
If those who read our content will help fund it, we can continue to bring you the very best in news and information. Please consider joining us as a valued member, or if you prefer, make a one-time contribution.Click for more info


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HAILING FROM THE NORTH EAST - Newcastle's Kub & Ken Masters are showing us how Hip Hop is suppose to be done.Read More
The ill Alliance General himself DJ Koncept has been non stop on the battle scene and has proudly just taken the well deserved title of 'UK DMC Supremacy Champion'.
Here's what the big man had to say for himselfRead More
Dublin heads! Tower Records is now stocking DJ Koncept's home grown Hip Hop single 'Belfast to Auckland' 7" vinyl featuring Stash & Steve Loc, with Seaz420 remix as well as skipless scratch loops for all your portable needs!Read More
Another fresh boom bap looper by Violentlyill is now added to TableBeats library. It's 7 dope beats taken from his project Ill Vibrations EP from 2016Read More
The direct ill Records plug for all your physic-ill needs…
'illstrumental Vol.1' just dropped and is now available in a Dope Vinyl style CD 🔥Read More
For all you scratch DJs out there!
"New fresh boom bap looper & beat tape, illstrumentals Vol.1, by ViolentlyillRead More
Spotify + Apple iTunes heads! 'illstrumentals Vol.1" is now live! Check it out, don't forget to add Violentlyill for more on the way! 🔥💣Read More
We've purposely put the CD up for £5, which is cheaper than the digital copy. WHY!? Because sometimes it's nice to have a physical piece for the tunes you bought!Read More
'DIVINE' Offical Video
Violentlyill just dropped his launch video for 'Divine', lifted off the 'illstrumentals vol.1' tape.
This classic sounding dusty lofi boom bap track now has a video that is equally on par with it's sound. A blend of dusty vintage footage and trippy visuals.Read More
Violentlyill's illstrumentals Vol.1 is wrapped up and the physicals are on their way to ill HQ.
The first in the series of Violentlyill's beat tapes. With 15 instrumentals and play total of just over an hour you can expect to hear the signature dusty 90s boom bap sounds that Violentlyill is known for.Read More


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On Match, dating profiles are very detailed. Learn More in these related Britannica articles: Women should not spend time with other men if they are dating someone.
Cultural differences can always be an issue between interracial couples, but I believe personality clashes are more critical than cultural ones. Want great dates in Manchester?
They believe in K-drama actors or idols and their characters to the point of thinking all or most Korean men look like one or act like one. This was a bad list, you could have done something much better!
Sapphire Speaking as a guy, I do think swedish women want everything to be equal, I mean what womwn wouldt want it?. Let our virtual online dating coach Lara be your guide to finding your ideal partner. Why not add a bit of humour, too? To me as a swedish guy it almost feels like doing all that, it means that one would think that women are not capable of doing that themselves.
How many men are there on the whole planet who would earn enough to support the whole family? This definitely includes bouts of ridiculous drunkenness.
And yes, some chivlary is nice but not too much, if a man try to pull out my chair it makes me laugh, do hold the door up, but next time when I walk thrpugh the door first, let me hold it up to him. April 27, at Traditional Mexican music is still alive in the voices of artists such as Lila Downs.
It is tough to be in an interracial relationship especially here in Korea, so it is vital to be with someone who respects and accepts who you are. At the very least, you should see the following promising signs: Arrange dates in the capital at our singles events.
Yes I do enjoy getting a beer payd for now and again, but the next round he better let me pay. You have to analyze if being apart from your family and friends and changing or altering your career is worth it.
You look like trouble! A few lines are enough to make an impression. I stay near Central stockholm. Here's a link to meet awesome girls worldwide!! Canadian men are more politically correct on the outside perhaps, but not on the inside.Fulfillment by Amazon (FBA) is a service we offer sellers that lets them store their products in Amazon's fulfillment centers, and we directly pack, ship, and provide customer service for these products.
Hey m a Sagi woman.
I have been living with my Leo man for the past three years. And we have been extremely loyal to each other. It is true that he loves loyalty. Tis the season to go decadent––rich pumpkin, bread crumbs, tempeh, turmeric, and a medley of mushrooms are all baked into this deliciously layered dish.
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The following editorial appeared in Thursday's Washington Post:
Senate leaders on Wednesday struck a far-reaching, two-year budget deal that would dispense with a bundle of issues that have bedeviled Washington for years, and they immediately took a victory lap. Majority Leader Mitch McConnell, R-Ky., called it "a significant bipartisan step forward," and Minority Leader Charles Schumer, D-N.Y., hailed it as "very good for the American people."
The deal would, indeed, do some good. And Senate leaders deserve credit for talking to one another and dealing in good faith, a model the House and the White House have resisted. Too bad it all had to come at the cost of more debt, confirming yet again that the only time Washington's leaders appear able to shake hands on big deals is when both sides agree to run up the national tab.
The agreement would, first and foremost, prevent another government shutdown and end the cycle of short-term funding crises that lawmakers have been inflicting on government agencies.
Military spending would see a big boost, as lawmakers finally respond to warnings from defense officials that funding uncertainty harms readiness. The Children's Health Insurance Program, which until the most recent stopgap budget deal was starved for funding, would get another four years of cash, bringing its total extension to a full 10 years. Another $90 billion would be pumped into disaster relief. The Senate plan would also devote $6 billion to the opioid crisis and $20 billion to infrastructure.
All of these things are good. Congress should have agreed on them months ago. But they are what used to be considered the easy part. Instead of raising revenue or reforming big entitlement programs to pay fully for government operations, senators would add billions more to the debt. Though they would offset some of the proposal's cost, they would not come close to covering all of it. While they would reap some savings from Medicare, a major cost driver, they would at the same time abolish the Independent Payment Advisory Board, one of the few potential checks on rising health-care spending that Congress has instituted in the past decade.
The reality denial is particularly pervasive among Republicans, who forfeited any moral authority they claimed on debt when they rammed through that huge tax bill. Their arguments that tax cuts will pay for themselves and that lawmakers should simply fill any gap with deep spending cuts are about equally preposterous. Now in near-total control of Washington, they are proving once again that they care about the debt only when it is a good campaign issue.
Is it too much to ask that Congress provide a reasonable level of government service, without near-constant drama, and pay for it? Apparently so.


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Stem Cells International
Volume 2016, Article ID 7828049, 12 pages
Modeling Alzheimer's Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
2Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA
3State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, China
Received 11 September 2015; Revised 10 December 2015; Accepted 20 April 2016
Academic Editor: Luciano Vellon
Copyright © 2016 Weiwei Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Alzheimer's disease (AD) is the most prevalent type of dementia and its pathology is characterized by deposition of extracellular β-amyloid plaques, intracellular neurofibrillary tangles, and extensive neuron loss. While only a few familial AD cases are due to mutations in three causative genes (APP, PSEN1, and PSEN2), the ultimate cause behind the rest of the cases, called sporadic AD, remains unknown. Current animal and cellular models of human AD, which are based on the Aβ and tau hypotheses only, partially resemble the familial AD. As a result, there is a pressing need for the development of new models providing insights into the pathological mechanisms of AD and for the discovery of ways to treat or delay the onset of the disease. Recent preclinical research suggests that stem cells can be used to model AD. Indeed, human induced pluripotent stem cells can be differentiated into disease-relevant cell types that recapitulate the unique genome of a sporadic AD patient or family member. In this review, we will first summarize the current research findings on the genetic and pathological mechanisms of AD. We will then highlight the existing induced pluripotent stem cell models of AD and, lastly, discuss the potential clinical applications in this field.


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When does it happen? Depends on the weather and your location on the globe (it won't happen at the North Pole, during winter), but you will usually encounter a soft lighting situation, at the edges of the day (also referred to the Golden Hours), just after sunrise and just before sunset (how much time before and after, is again dependent on.
BRITISH POLICE HAVE arrested a pensioner on suspicion of murder after a suspected burglar at his home in southeast London was fatally stabbed to. and a post-mortem examination will be carried out "in due course", according to.
Kenny Lee Photography Through the work of renowned photographers and documentarians, these untold. Lee Ann Womack, Lyle Lovett, Merle Haggard, Rosanne Cash, Kenny. Preservation Hall, 1982 Photo by Lee Friedlander. Courtesy of the
List of camera and photography shops. See also list of camera and photography museums. This is a list of photography shops that sell classic cameras, used equipment, second hand equipment, accessories.
Find the latest Part Time jobs in London (West) on Gumtree. Hunt for a new job, or hire people for your business.
Of course, with two billion of their closest friends. It's unclear if any of these quotes are truly correct. Only the bride herself knows what William stated to her on the altar. But that won't stop us from reviewing the tape time and time again.
Welcome to Wigan & Leigh College offer a wide range of courses for all levels. We are proud of our school of excellece and superb facilities.
Robert Sietsema, who has been doing the job for 25 years and is currently a food critic at Eater, says this is the weirdest thing about the job: "being focused on food literally all of the time. course, there's the question of anonymity,
Coursera provides universal access to the world's best education, partnering with top universities and organizations to offer courses online.
Jayce North, 22, said the major parties seemed more interested. disaffected voters from both sides of politics across a range of issues. Lizzy Madden, a part-time seamstress in Ipswich, said she liked all of Ms Hanson's views except for one.
Course summary. The Photography Arts MA offers a dynamic mix of photography practice and research to support your development as an artist. In an open-minded educational environment you will expand the boundaries of your photography, advancing your own distinct visual and conceptual approach.
"There's a scrum of photographers all fighting for a shot of a celebrity and their child," says photographer Giles Harrison of London Entertainment Group. civil action and increase fines and jail time for the "intentional harassment.
That is why he is using the outburst as part of his campaign. It's the candid nature of explosions like Bost's that we seem to value, a chance to see the "true" candidate. Cynics will doubt that, of course. But the point is not whether we believe.
But he also acknowledges that while many of the regions he has visited are known as places of conflict, conflict.
San Francisco ranked seventh in the survey in the fourth quarter of last year, but in the most recent survey beat out London, Tuscany, New York and Paris, which were also in the top-five most-desirable international locations for.
Transport has been disrupted as one company, Go North East, last night cancelled all of its services. Ges Smith,
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This is a huge part of street photography of course, but it is only one part, and it can cause confusion over the true meaning of what street photography really is all about, and how it can be done.
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Canon Rebel T3 Photography Classes Kenny Lee Photography Through the work of renowned photographers and documentarians, these untold. Lee Ann Womack, Lyle Lovett, Merle Haggard, Rosanne Cash, Kenny. Preservation Hall, 1982 Photo by Lee Friedlander.
A MAYO MAN who has become known for his high-profile protests against Anglo Irish Bank – including the Achillhenge structure on Achill Island – has unveiled a protest structure in the heart of London. over the course of one weekend,
His letter, dated 3 December 2008 confirms that photography can be "limited" in public places. breach of the peace in England and Wales is at present far more limited than north of the border. In Scotland, Police may – and frequently do – arrest.
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The Friends of New London, a group that works to. The purchase has been in the works for the better part of a year and a half, Lichtenberger said, but it didn't come to fruition until this week. Over the course of a year and many talks, the.
We're investing in an exciting, multimillion pound transformation of the London Metropolitan University campus, between 2016 and 2020. We're moving all of our activity to one place, our current Holloway campus in Islington, north London.
We know this because Cook has been publicly sharing updates about his travels with his 4.1 million Twitter followers, posting a stream of new photos with the zeal of a work colleague flooding their friends' timelines with vacation photos. While it looks as.
LONDON — Benedict Cumberbatch has been attached to star in the thriller "Blood Mountain," which Altitude Film Sales will be shopping to international buyers at the European Film Market in Berlin. UTA Independent Film Group is repping North American.
One thing that never occurred to me, however, is that it would be part of a university curriculum. The Telegraph reports that the novel is once again being banned, this time. London, said that after decades of teaching the provocative text on various.
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To see more of my photography for RIDI and to find out more about the RIDI Awards and the great work Recruitment Industry Disability.


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HARRISON, Ark. — The Crowder Lady Roughriders showed Tuesday night that it's not how you start but how you finish that counts after their 86-78 win over the North Arkansas Lady Pioneers at the Durand Center.
Crowder outscored North Arkansas 33-22 in the fourth quarter, erasing a 56-53 deficit after three quarters.
Tuesday's win gave the Lady 'Riders their 13th of the season and that number eclipses last season's 12 wins, already in 14 fewer games. Crowder's win stopped a two-game skid with both losses on the road, first Iowa Western and then Mineral Area in the Region 16 opener for the Lady 'Riders.
Crowder, 13-6 overall and 0-1 Region 16, returns to action Saturday in a home contest at Bob Sneller Gymnasium against Region 16 foe Three Rivers. Crowder and Three Rivers tip at 2 p.m.
On Tuesday night, Crowder, playing without sophomore post Zahria White for the fourth straight game, received double-digit scoring games from four different players.
Tori Coulter, behind five 3-point shots, led the way with 17 points and freshman Maegan Bandimere, who hit a pair of trifectas, added a career-high 16 points, beating her previous high of 12 scored Dec. 9 against Eastern Oklahoma.
Bandimere, a native of Fort Smith and a graduate of Fort Smith Northside, played her best collegiate game so far in her home state.
Coulter and Bandimere combined for seven of the team's nine 3-point shots.
Sophomore point guard Michaela Mack finished with 15 points and freshman forward Alex Vogt added 12, while sophomore Coley Ickes and freshman Elle Williams had nine and seven points, respectively.
Morgan Crawford, Bethaney Gilkey, and Aubrie Ayers rounded out the scoring with five, three, and two, respectively.
Hannah Villines scored a game-high 29 points to lead the Lady Pioneers, who also had 15 from Kyra Kahn and 13 points each from Morgan Clemence and Maya Hood.
Crowder improved to 3-0 in games this season at North Arkansas' Durand Center, the Lady 'Riders victorious there earlier this season against John Wood (80-73) and Eastern Oklahoma (102-75) in the Lady Pioneer Classic.
During three wins in Harrison, Crowder averaged just under 90 points per game.
Three Rivers enters Saturday's contest 13-7 overall and 1-2 Region 16, with consecutive losses against Moberly (81-49) and State Fair (94-87).
The Lady Raiders average 78.6 points, 40.2 rebounds, and 16.4 assists per game.
Four players average double-digit scoring for Three Rivers: Lakeita Chappel 13.8, Alex Kohler 13.0, Hailee Erickson 11.8, and DeNayia Holmes 10.8. Chappel, Erickson, and Holmes have started all 20 games for the Lady Raiders.
Holmes, a redshirt sophomore guard, averages 3.6 rebounds, 4.7 assists, and 2.6 streals, while sophomore Kahliya Murry averages 2.9 blocked shots, good for 10th in all of NJCAA Division I.
Speaking of national leaders, Crowder, one of the best all season, still led NJCAA-I in free throws attempted (534) and ranked third in free throws made (350) entering Tuesday's contest.
The Lady 'Riders host Alumni Day on Feb. 3 against none other than North Arkansas, which turns out to be the last non-Region 16 opponent of the regular season.
Crowder head coach Tina Wilson announced that the 2012-13 NJCAA national tournament squad of five years ago will be recognized.
Crowder posted a 29-6 overall record that season, finishing 16-3 at home, 10-2 away, and 3-1 at neutral sites.
Leaders on that squad included sophomores Sarah Sagely (later a Crowder assistant), Terai Sadler, Caprese Marshall, Chloe Nichols, Caitlin Miller, and Veronica Amos, plus freshmen Dorian Briggs and Camila Lacerda.
Sadler, a native of New Zealand, closed out her collegiate career at Central Arkansas and now plays professionally overseas.
Sagely moved on to Northeastern State, Lacerda to Missouri Southern (now she's the head coach at Ozark Christian College in Joplin), Briggs to Lincoln, Amos to Texas A&M International, and Marshall to Columbia College.
Crowder 18 15 20 33 — 86
North Arkansas 14 21 21 22 — 78
CROWDER (13-6) — Coley Ickes 9, Tori Coulter 17, Maegan Bandimere 16, Aubrie Ayers 2, Bethaney Gilkey 3, Michaela Mack 15, Morgan Crawford 5, Alex Vogt 12, Elle Williams 7.
NORTH ARKANSAS (10-4) — Kiara Franklin 1, Hannah Villines 29, Ashlyn Taylor 2, Kyra Kahn 15, Morgan Clemence 13, Maya Hood 13, Grace Coates 5.
3-point goals — Crowder 9 (Coulter 5, Bandimere 2, Ickes, Williams), North Arkansas 5 (Kahn 2, Clemence 2, Coates).


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Important Solutions for Best Trekking Holidays in the World
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The Hagley Digital Archives provides online access to selected items from the Hagley Library's collection of images, documents, and publications related to the history of business, technology, and society.
Correspondence, Rodmond Gibbons to E. I. du Pont de Nemours and Company, 1860-11-10
Gibbons reports on his powder stock.
Gibbons, Rodmond
GunpowderOrdnance industry
San Francisco (Calif.)
business correspondence
1 item (2 pages)
reformatted digital
Manuscripts and Archives Department, Hagley Museum and Library
E.I. du Pont de Nemours & Company records (Accession 0500.I)
Described in 'A Guide to Manuscripts in the Eleutherian Mills Historical Library, accessions through the year 1965' by John Beverly Riggs
Part I, Series B, Box 108
[Description and dates], Hagley ID, Box/folder number, E.I. du Pont de Nemours & Company records (Accession 0500.I), Manuscripts and Archives Department, Hagley Museum and Library, Wilmington, DE 19807
Access to this item is provided for educational and research purposes only. The user assumes responsibility for obtaining permission from the copyright holder to publish or distribute this image. If you would like more information, please contact firstname.lastname@example.com


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