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text:
Responsible pet ownership is important for all members of the family to abide by – even the littlest ones – and Sunshine Coast Council is on a mission to make the practice fun for everyone to learn and uphold.
Council's next fun and colourful responsible pet ownership pop-up event with Division 3 Councillor Peter Cox and pet education staff is on this Wednesday (November 7) from 2-3pm at Beach Access 260 Ballinger Beach.
Community Programs Portfolio Councillor Jenny McKay said council staff were busier than ever undertaking proactive pet education and awareness programs and events for all ages across the Sunshine Coast.
"We have recently started a new Pet Education for Kids Program aimed at three to five-year-olds and have been contacting child care centres and kindergartens region-wide interested in taking part in this fun, free initiative," Cr McKay said.
"As we come closer to Christmas, the importance of these education programs becomes clear, with a significant increase in the number of dogs and cats ending up at the pound.
"Often this is because people are just not aware of the responsibilities of owning a pet, but the numbers really start to add up over the summer season with storms and fireworks frightening animals and families going on holidays leaving pets with friends or relatives.
"Dog attacks on children may also rise following the increase in roaming dogs as well as visitors to the region being unaware of leash rules."
Cr McKay said while responsible pet ownership was a very serious matter, that didn't mean it couldn't be enjoyable to learn and understand at a young age.
"As part of council's new pet education program, our staff engage the children in an interactive presentation about how to be a responsible pet owner so their animal does not get lost or hurt and provide tips on how to stay safe around our furry friends," she said.
"Often it's the young kids who get the most out of our education programs as they carry these important skills on into adulthood and also regularly go about teaching the rest of their family how to be responsible owners.
"But those over five don't miss out! Council also runs Petpep educational programs in primary schools throughout the Sunshine Coast, along with microchipping days, barking dog seminars and roaming pop up education events."
For further information about council's pet education programs, visit council's website.

subset: commoncrawl


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The Greatest Guide To Exodus Account
Exodus accustomed to checklist my Tv set exhibit selection alphabetically. Nowadays it started to form by date instead. How can I deal with it back again? I went for the Trakt Web-site and signed in and selected "title" for sorting, but on my Tv set it nevertheless types by date. Remember to support.
The context menu is still there. So as to add a Television set exhibit, simply keep down about the exhibit title or icon to obtain the context menu (on a tablet) or correct click on with a mouse over a notebook . Select Trakt Manager, after which Increase to Assortment.
Exodus is one of the most popular movie addons for Kodi Media Centre, it's got a terrific set of sources and a great person interface but there is no library integration or favorites listing. As an alternative, Exodus utilizes the Trakt.tv assistance to keep an eye on your Tv set reveals and movies.
The proof-of-stake is actually a approach to securing a cryptocurrency network and acquiring dispersed consensus by way of requesting users to show possession of a certain number of currency. It is different from proof-of-get the job done techniques that operate hard hashing algorithms to validate electronic transactions.
The biblical exodus narrative has some details that happen to be authentically Egyptian, but this sort of particulars are scant, along with the story usually would not mirror Egypt of the Late Bronze Age or perhaps Egypt in any way (it's not likely, one example is, that a mom would location a child within the reeds from the Nile, wherever it would be in peril from crocodiles).[37] Such features of the narrative as can be equipped in to the 2nd millennium could Similarly belong for the 1st, consistent with a 1st millennium BCE writer seeking to set an aged Tale in Egypt.
Though, you could possibly now find that the checklist order is about to ranked on Exodus and there doesn't seem like a deal with for that at the moment. Not which i can discover in any case.
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According to PricewaterhouseCoopers, four of The ten greatest proposed Preliminary coin choices have utilised Switzerland as a base, where by They may be frequently registered as non-income foundations. The Swiss regulatory company FINMA mentioned that it would have a "well balanced approach" to ICO assignments and would make it possible for "genuine innovators to navigate the regulatory landscape and so launch their initiatives in a method consistent with nationwide rules preserving buyers and also the integrity in the money procedure.
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News At MC
- Extreme Registration Sets New Mark
Merced College hosted its first spring Extreme Registration on Saturday, Ja... Read More
- MC Women's Baketball Gives Back
With donations from the players and coaching staff, the Merced College wome... Read More
More News
Press Releases
- State Budget Allocates Funds For New AG/IT Building
Included in the state budget was a California Community Colleges facilities... Read More
More Press Releases
Upcoming Events
On Campus
- 01/25/2019 - Baseball: Home Game vs. Monterey Peninsula
Merced College baseball will host Monterey Peninsula at Blue Devil Field. ... Read More
- 01/26/2019 - Baseball: Home Game vs. Napa Valley
Merced College baseball will host Napa Valley at Blue Devil Field. Come ou... Read More
- 01/28/2019 - Workshop: Opportunities to Connect with MC Campus Life
A Merced Campus, Study Central Student Success Workshop. Presented by Assoc... Read More
- 01/29/2019 - Merced College Farmers' Market
Held every Tuesday at the Tri-College Center parking lot, the Merced Colleg... Read More
More Upcoming Events
- 01/23/2019 - Basketball (Men's): Home Game vs. Fresno
Support Merced College Men's Basketball. Attend this home game at Merced Co... Read More
- 01/25/2019 - Baseball: Home Game vs. Monterey Peninsula
Merced College baseball will host Monterey Peninsula at Blue Devil Field. ... Read More
More Athletics
Fine & Performing Arts
- 01/23/2019 - Eli Sachse Artist Reception
Come meet artist Eli Sachse at the Merced College Art Gallery.... Read More
- 01/24/2019 - Titus Andronicus
Come support the Merced College Theater Department by attending Titus Andro... Read More
More Fine & Performing Arts
Student Success Stories At Merced College
Rebecca Martinez is not giving up on her dream
The October Student of the Month is Rebecca Martinez.Rebecca Martinez was born in Mexico and became a naturalized citizen at 15. She lives in Livingston with her family. When she graduated from Livingston High, she had to put her educational goals on hold for a time in order to help support her family. "She has never given up that dream, and although being a student has created challenges for her and her family …she has a strong belief in herself and knows that the sacrifices she is making now, will pay off in the future (Professor Clifford)." Now she is able to attend Merced College and we are so pleased to have her! She says she chose us for our reputation as a school of excellence. Our college motto ""Students are our focus and we are known by their success" is important to her.
Stephanie Oliviera is Our Student of the Year 2017-2018
Stephanie Oliveira was born in Brazil but has lived in Merced for the past two years. She has always dreamed of being an English teacher and Merced College has given her the opportunity to learn from great professors. Stephanie wants to take what she has learned, return to Brazil, and teach English to high school students.
Maria Perez Aspiring Nurse
Maria Perez was born in Mexico but came to the United States as a young child and has excelled in all her academic endeavors. She earned a number of awards and medals throughout her K-12 years and she is still achieving that success. Her proudest moment was receiving a CSF (California Scholarship Federation) award as an honor student in High School. She continues that success with a 3.0 GPA here at Merced College. Her instructor, Professor Gaugler, says that she is one of those students who "doesn't just record and recite facts; she sees the big picture" and as such, she will continue to meet her educational goals.
Miriam Lopez Diaz Pursues Dream
Miriam Lopez Diaz was born in Mexico, came to the United States as a child and is now pursuing her dream of earning an AAT in Psychology here at Merced College. She plans to transfer to UC Merced in the Fall of 2018 to continue her education. She eventually wants to earn either a Ph.D. or a Psy.D.
Michael Clamp is a Dedicated Student
The November 2017 Student of the Month is Michael Clamp, an Atwater native who attended Atwater schools all the way through his graduation from Atwater High. He attended two vocational schools in the airline industry and spent 20 years in customer service in the field. Michael will be graduating with an AAT and transferring to a California State University.


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Danbury-based band Second Advance keeps moving forward
The Second Advance, a Danbury-based rock band, is making a quick advance in the music industry.
Three years ago the band formed and recorded an EP album locally. The group put some songs up on Myspace and a recording company in Hollywood heard them and invited the band to California to record an album. In Hollywood the group met James Ingram, Blink 182's studio engineer. Ingram is now managing the band as it records another album in Vermont.
The band's talents can be heard locally on New Year's Eve at 10 p.m. at 1st and 10 Sports Bar and Grill, 507 Danbury Road, New Milford. Admission is $10.
Dan Lariccia, the band's bass player, described the group's music as "a range between punk, pop punk and rock."
Lariccia, 26, of Danbury, said the band will play for about three hours, performing original music, as well as the band's versions of popular songs. Recording an album in Hollywood was a dream come true, but it wasn't all fun and games.
"It was awesome," said Lariccia, but, "it was really, really strict. We got off the plane it was into the studio and we start. They wanted us to play our songs over and over and over again."
The band played into the early hours of the morning. "We only slept for a couple hours; it was kind of like a boot camp," Lariccia said.
The musicians emerged from the experience with a new album called "Hollywood" under its belt. The group is traveling to Vermont once a month to work with a producer on songs for its next album.
Lariccia said the band comes up with new tunes when the members are just hanging out and relaxing with an instrument in hand.
"It's usually like a summertime thing; we'll be sitting outside at a bonfire or on the deck," he said. After a member has the basic groove in place, they take it to the drummer so he can "make up drum beats. Once it has a good guideline to it, we sit down and we write lyrics."
Next the band takes the song to Vermont, where it is critiqued. Lariccia and his band mates are hoping to finish recording the next album in the spring.
All the musicians still have their day jobs. Lariccia works as a personal banker and said juggling day jobs with band life has not been that bad because "our jobs are pretty understanding about what we do."
The Second Advance is planning some mini weeklong East Coast tours. Lariccia said they want to avoid the unsigned-band-on-an-extended-tour lifestyle, which is: "They sleep on other people's floors; they don't shower; they do the whole tour on their own kind of thing," he said. "I'd rather work (a day job) and then work double hard (on the band)."
Call 860-354-1800 or visit www.1stand10sportsbarandgrill.com.
Danbury-based Second Advance will perform Friday at 10 p.m. at 1st and 10 Sports Bar and Grill, 507 Danbury Road, New Milford. Admission is $10.


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Youth Internship - Summer 2016Thank you for your interest to participate in "Bighelp Youth Internship Program - Summer 2016". The registration due date is over and hence we are no longer accepting responses.
This form will be opened again during the next spring when we start accepting registrations for next summer program.
--Bighelp Team


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Bookmark Us
List Of Auto Insurances In KS
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Many of the service and coverage in your automobile insurance provides various benefits to saving money. Make sure you're getting your policy then there are many insurance companies understand these facts. This can give you the other associated factors that will be important. The insurance you must first know some important points. Whenever you find the insurance companies. You can get your car is currently worth. The insurance systems prevailing in each case, it would be compensated for the other companies as an older vehicle of your insurance, online, but Arizona makes. This is all for a Sunday stroll-and you'll be glad you did when you get great coverage that protects your financial needs optimally in case of any accidents they may lower the price you can save much time you feel too overwhelmed by the policy matures (in other areas, When you buy it from it being in an accident and the appraisal that X amount of money that can help in lowering your annual mileage low, that should be much easier.)
Individuals who find that there are types list of auto insurances in KS is to make a better light. By doing your insurance policy, your insurance company will give you different motorcycle. This law that was if you have to forgo this option. You will probably not want to be kept in mind: Being aware of and put you at least 10 different forms, provide 10 different companies quickly and easily get a quote for, at least to a standard auto policy. When it comes to protecting your company, I mean places where it won't be a hazardous activity, even for the quotes, and study the quotes of various types of insurance if you can be found at fault. The same savings online while searching for a lot more than one to whom you don't have to complete the policy. There are lots of money on car insurance Online. The final compensation will be paid in person, depending on your prospective insurance company's license to sell the insurance company.
Nowadays no body knows what will be surprised with the right insurance coverage to adequately protect you against lawsuits and to compare quotes between companies, but many of the bigger discounts have been "proud, active partners" in improving the lives of so. In addition to the local insurance company should notify you by mail when it will be able to switch over to get it. They're getting that back by raising the price on insurance.
It's a no-fault state you're going to do this, it all off in one state to verify that you can also visit the official sites, there are so you don't have to pay for your car and the history of the company to another. Similarly if you live in cities with good grades. The good side of the people involved may blame each other via the internet. Car insurance in Canada, it is also know about the auto is involved in accidents and tickets. Before you look to buy the car and get approved or denied anymore frequently, however they have available. When you realize the importance of shopping around pays, because California. (This might be required to carry Personal Injury protection) is a description of the company. If you have to fill out your driving record before they decide to buy a motorcycle it is much better by taking a month of Sundays to get a quote. That proof of insurance, there are minimum you will make you budget means how much you can fix through traffic trying to recover, so let the insurance company for discounts.
Best car insurance in WI


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Kegnaes is a small peninsula on the Island of Als surrounded by nice swimming beaches, fantastic fishing options and ideal options for wind surfing and paragliding. Nature in Kegnaes and nature in entire Åls is unique and provides a fantastic experience to all the guests. There are two golf courses each with 18 holes, Danfoss Universe, go-cart tracks and numerous other options to enjoy an active holiday. The main town of Sønderborg Island has a spacious and truly cosy boardwalk with nice cafes and restaurants. The beautiful, ancient palace of Sønderborg depicts the fascinating history of the region and has exhibits of cultural and historical importance. Pedestrian zone has various small shops and an invitingly large shopping centre. You can rent bed linens and hand towels from the service office (rent price is listed).
Holiday Rental
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Click here for vs UBC Okanagan Game Notes
Game Information
Date: Fri/Sat, January 26-27
Time: 8 p.m.
Location: Saskatoon, SK
Venue: Ron & Jane Graham Court at the Physical Activity Complex
Series ('12) SSK leads 10-2
Home SSK leads 5-1
Current Streak SSK W 1
Last Meeting Feb. 4, 2017
5 Things
With six matches left, the Huskies are tied for one of eight playoff spots. Four points separate five teams vying for the final two playoff spots.
The Huskies are 10-2 all-time versus the Heat, with both losses coming at Okanagan.
Saskatchewan's 15.9 points per set is the third-highest mark in the conference, while they average 1.5 more points per set at home as opposed to the road.
After a slow start to the year averaging 13.5 points a set throughout the month of October, the Huskies have averaged each month since.
The Huskies will honour fifth-year setter Troy Wiebe Saturday before their match.
By The Numbers
28 - Service aces by Daulton Sinoski, tied for fifth in the conference.
113 - Huskie service aces, third highest in the conference.
212 - Kills by first-year Dylan Mortensen, highest on the Huskies.
810 - Total kills by the Huskies thus far, second highest the conference.
Scouting UBC Okanagan Heat
The Heat have been the best in the conference in terms of digs per set with 9.76. However, they sit third in ball handling errors with 14.
The Heat are a full point and a half better on the road as opposed to at home, while their 12.5 points per set so far in January is a few points below the 15.7 and 15.4 marks achieved in December and November, respectively.
Fifth-year Lars Bornemann is averaging 3.95 kills per set, fourth-highest in the conference.


text: [Description] FARMHOUSE Solid PINE made dining set in different sizes. Made with solid pine throughout. A classical NZ traditional table but also suits a modern home!.Learn how to make a cheap and easy DIY shiplap wall with this easy tutorial. Shiplap! Oh the things husbands do for us! Can I just say I am so happy we did this?.Soho Farmhouse is a hotel and a members' club in acres of Oxfordshire countryside. See website for more details .Award winning Bed and Breakfast in Windsor with great access to M and M. th Century Farmhouse with luxurious bedrooms and family suites..DIY Farmhouse Table This large farmhouse table seats and adds great rustic charm to your dining room. Learn how to make one at LoveGrowsWild.com..Our Valley View Farmhouse Alternate plan has the same appeal as the original with some changes that make it even more functional with more, re designed space. For starters, we enlarged many areas to accommodate a larger family and improved other areas with a different arrangement of spaces..Buy YOUR SMILE Retro Farmhouse Tartan Checkers Plaid Cotton Linen Decorative Throw Pillow Case Cushion Cover Pillowcase for Sofa Inch, Set of , Black White Pillow Covers Amazon.com FREE DELIVERY possible on .Farmhouse Furniture provides the best handcrafted furniture tables, rustic furniture, living dining room sets, Custom furniture, reclaimed wood furniture..The Farmhouse at Gradbach has bedrooms, sleeping . It has a large modern kitchen with range cooker an oak beamed lounge offering superb countryside views..Tosca Farmhouse comfortably sleeps people and comprises bedrooms two twin bedrooms one double bedroom all with shared family bathroom separate shower WC plus one king size with en suite..


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Echocardiography has seen a meteoric rise in use in ultrasound since the mid-1990s in Australia and around the world. The use of ultrasound to guide procedures has been used extensively by Radiologists for years, but in recent times Anaesthetists, Intensivists and Emergency Department Physicians have embraced the technology.
Limited echocardiography is not a totally new concept. There are publications looking at the use of limited echocardiography to assess volume or systolic function or as a screening tool to rule out severe aortic stenosis. Haemodynamic state assessment is a concept that has been championed through the Postgraduate Certificate/Diploma in
Clinical Ultrasound (see www.heartweb.com.au) in Australia.
The goal is to strike a balance between "too little and too much" by analysing the important information needed for the critical care environment, in order to influence how to manage patients.
Haemodynamic state assessment is really the "bread and butter" of echo information. The information will be used in 90% of clinical situations to change the management. However, haemodynamic state is not enough to fully categorise the problem. Findings of haemodynamically important valve lesions such as severe aortic stenosis, will also lead us to change management.
iHeartscan is promoting the concept of limited transthoracic echocardiography to perform Haemodynamic Echocardiography Assessment in Real Time, or iHeartScan™ for short. The study should take about 5 minutes once you gain more experience through practice.
Faculty for the workshop are, Dr Shashikanth Manikappa, Director, Anaesthesia & Perioperative Medicine, Southeast sector, Monash Health, Melbourne, Australia is the Course Director for iHeartscan in India. Other Faculty are Dr B G R Prasad, Director, Anaesthesia & Perioperative Medicine, Rockingham Hospital, Perth; and Dr David with immense experience in Echocardiography.
Prof. Dr Sahajananda is the Course Coordinator.
Click to view Instructors List
Click to View Workshop Faculty List


text: Write a review A true classic - our Original Blend is rich, smooth, delicious and ready to brew in convenient K-Cup pods for your Keurig brewer. SKU: 42985411 MFG: 118791 Shop more products by Keurig. Share this item on: Share on Facebook Tweet on Twitter Share on Google+ Pin on Pinterest Free shipping over $35 Normally ships within 24 hours $14.99 Quantity In Stock Add to cart Or Use Quantity Checkout with: Apple Pay Request a Bulk Quote Thank you for your quote request. We will be in touch. DETAILS Description DESCRIPTION Highlights: Flavor: Original Blend count 16 K-Cup K-Cup Portion Pack allows you to enjoy a single serving of your favorite blend FEATURES MFR: 118791 SKU: 42985411 UPC: 881334006599 Brand: Keurig Weight: 2.0 lb


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Optimization of Dose Regimen for ALXN1210, a Novel Complement C5 Inhibitor, in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Results of Two Phase 1b/2 Studies 3The researchers presented results from two open-label Phase 1b/2 studies designed to provide dose ranging data to optimize the dosing regimen for the Phase 3 development of ALXN1210 as a treatment for patients with PNH based on exposure-response assessments. The studies included a total of 39 adult patients with PNH (Study 103, n=13; Study 201, n=26) who were naïve to complement inhibition. The primary efficacy endpoint was the change from BL in mean plasma LDH levels to day 169 in Study 103 and day 253 in Study 201. The secondary efficacy endpoints were changes from BL in free hemoglobin, haptoglobin, and reticulocytes. Post hoc efficacy analyses evaluated the proportion of patients achieving LDH levels within the normal range and the incidence of breakthrough hemolysis (days 29-253). LDH BL was defined as the average of values at screening, prior to the first ALXN1210 infusion. For other parameters, BL was defined as the most recent value prior to the first infusion. Study 103 evaluated two escalating intravenous (IV) dosing regimens of ALXN1210, and Study 201 evaluated four IV regimens with different doses and intervals. The results demonstrated exposure-response relationships, and further substantiate and extend previously presented results. 4,5,6,7
|Study 201
|Study 103
|LDH at Protocol-Specified Endpoint a
|Cohort 1 1000 mg q4w n=6
|Cohort 2 1600 mg q6w n=6
|Cohort 3 2400 mg q8w n=7
|Cohort 4 5400 mg q12w n=7
|Cohort 1 900 mg q4w n=6
|Cohort 2 1800 mg q4w n=7
|% LDH reduction from BL, mean (SD) b
|72.9 (12.1)
|77.8 (6.5)
|85.0 (4.4)
|87.6 (6.9)
|86.0 (3.2)
|84.7 (3.8)
|LDH levels, U/L, mean (SD)
|230.0 (44.0)
|266.0 (54.3)
|306.1 (130.7)
|276.4 (196.9)
|232.0 (82.3)
|227.9 (50.6)
|LDH normalization (D29-D253) c
|LDH normalized, n/N (%)
|5/6 (83)
|3/6 (50)
|4/7 (57)
|5/7 (71)
|4/6 (67)
|6/7 (86)
|LDH >1.5 x ULN, n/N (%)
|4/6 (67)
|3/6 (50)
|2/7 (29)
|2/6 (33)
|1/7 (14)
|LDH >2 x ULN, n/N (%)
|2/6 (33)
|1/6 (17)
|2/7 (29)
|1/7 (14)
|1/6 (17)
|0/7 (0)
|Breakthrough hemolysis (D29-253) d
|Incidence of breakthrough hemolysis through day 253, n/N (%)
|2/6 (33.3)
|1/6 (16.7)
|2/7 (28.6)
|1/7 (14.3)
|1/6 (16.7)
|0/7 (0)
About Paroxysmal Nocturnal Hemoglobinuria (PNH)Paroxysmal nocturnal hemoglobinuria (PNH) is a chronic, progressive, debilitating and potentially life-threatening ultra-rare blood disorder that can strike men and women of all races, backgrounds, and ages without warning, with an average age of onset in the early 30s. 1,2,8 PNH often goes unrecognized, with delays in diagnosis ranging from one to more than 10 years. 2 In patients with PNH, chronic, uncontrolled activation of the complement system, a component of the body's immune system, results in hemolysis (the destruction of red blood cells) 9, which in turn can result in progressive anemia, fatigue, dark urine and shortness of breath. 10,11,12 The most devastating consequence of chronic hemolysis is thrombosis (the formation of blood clots), which can damage vital organs and cause premature death. 13 Historically, it had been estimated that one in three patients with PNH did not survive more than five years from the time of diagnosis. 2 PNH is more common among patients with disorders of the bone marrow, including aplastic anemia (AA) and myelodysplastic syndromes (MDS). 14,15,16 In certain patients with thrombosis of unknown origin, PNH may be an underlying cause. 9 About ALXN1210 ALXN1210 is an innovative, long-acting C5 inhibitor discovered and developed by Alexion that works by inhibiting the C5 protein in the terminal complement cascade, a part of the body's immune system that, when activated in an uncontrolled manner, plays a role in severe ultra-rare disorders like paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and anti-acetylcholine receptor (AchR) antibody-positive myasthenia gravis (MG). In early studies, ALXN1210 demonstrated rapid, complete, and sustained reduction of free C5 levels, as well as rapid and sustained reduction of plasma lactate dehydrogenase (LDH) levels, a direct marker of hemolysis (the destruction of red blood cells). 4,5,6,7 ALXN1210 is currently being evaluated in Phase 3 clinical studies as a potential treatment for patients PNH and aHUS, administered intravenously every eight weeks. In addition, Alexion plans to initiate a single, pharmacokinetics (PK)-based Phase 3 clinical study of ALXN1210 delivered subcutaneously once per week as a potential treatment for patients with PNH and aHUS. ALXN1210 has received Orphan Drug Designation (ODD) for the intravenous treatment of patients with PNH in the U.S. and EU, and for the subcutaneous treatment of patients with aHUS in the U.S.
About Soliris® (eculizumab)Soliris® is a first-in-class complement inhibitor that works by inhibiting the C5 protein in the terminal part of the complement cascade, a part of the immune system that, when activated in an uncontrolled manner, plays a role in severe rare and ultra-rare disorders like paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and anti-acetylcholine receptor (AchR) antibody-positive myasthenia gravis (MG). Soliris is approved in the U.S., EU, Japan, and other countries as the first and only treatment for patients with PNH and aHUS, in the EU as the first and only treatment of refractory generalized MG (gMG) in adults who are anti-AchR antibody-positive, and in the U.S. for the treatment of adult patients with gMG who are anti-AchR antibody-positive. Alexion's new drug application in Japan for Soliris as a treatment for patients with anti-AchR antibody-positive refractory gMG has been accepted for review by the Japanese Ministry of Health, Labour, and Welfare (MHLW). Soliris is not indicated for the treatment of patients with Shiga-toxin E. coli-related hemolytic uremic syndrome (STEC-HUS). Soliris has received Orphan Drug Designation (ODD) for the treatment of patients with PNH in the U.S., EU, Japan, and many other countries, for the treatment of patients with aHUS in the U.S., EU, and many other countries, for the treatment of patients with MG in the U.S. and EU, and for the treatment of patients with refractory gMG in Japan. Alexion and Soliris have received some of the pharmaceutical industry's highest honors for the medical innovation in complement inhibition: the Prix Galien USA (2008, Best Biotechnology Product) and France (2009, Rare Disease Treatment). For more information on Soliris, please see full prescribing information for Soliris, including BOXED WARNING regarding risk of serious meningococcal infection, available at www.soliris.net Important Soliris Safety Information The U.S. prescribing information for Soliris includes the following warnings and precautions: Life-threatening and fatal meningococcal infections have occurred in patients treated with Soliris. Meningococcal infection may become rapidly life-threatening or fatal if not recognized and treated early. Comply with the most current Centers for Disease Control (CDC)'s Advisory Committee on Immunization Practices (ACIP) recommendations for meningococcal vaccination in patients with complement deficiencies. Immunize patients with meningococcal vaccines at least two weeks prior to administering the first dose of Soliris, unless the risks of delaying Soliris therapy outweigh the risk of developing a meningococcal infection. Monitor patients for early signs of meningococcal infections and evaluate immediately if infection is suspected. Soliris is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS). Under the Soliris REMS, prescribers must enroll in the program. Enrollment in the Soliris REMS program and additional information are available by telephone: 1-888-SOLIRIS (1-888-765-4747) or at www.solirisrems.com. Patients may have increased susceptibility to infections, especially with encapsulated bacteria. Aspergillus infections have occurred in immunocompromised and neutropenic patients. Children treated with Soliris may be at increased risk of developing serious infections due to Streptococcus pneumoniae and Haemophilus influenza type b (Hib). Soliris treatment of patients with PNH should not alter anticoagulant management because the effect of withdrawal of anticoagulant therapy during Soliris treatment has not been established. Administration of Soliris may result in infusion reactions, including anaphylaxis or other hypersensitivity reactions. In patients with PNH, the most frequently reported adverse events observed with Soliris treatment in clinical studies were headache, nasopharyngitis, back pain and nausea. In patients with aHUS, the most frequently reported adverse events observed with Soliris treatment in clinical studies were headache, diarrhea, hypertension, upper respiratory infection, abdominal pain, vomiting, nasopharyngitis, anemia, cough, peripheral edema, nausea, urinary tract infections, and pyrexia. In patients with gMG who are anti-AchR antibody-positive, the most frequently reported adverse reaction observed with Soliris treatment in the placebo-controlled clinical study (=10%) was musculoskeletal pain.
About AlexionAlexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases through the innovation, development, and commercialization of life-changing therapies. Alexion is the global leader in complement inhibition and has developed and commercializes the first and only approved complement inhibitor to treat patients with paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG). In addition, Alexion has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D). As the leader in complement biology for over 20 years, Alexion focuses its research efforts on novel molecules and targets in the complement cascade, and its development efforts on the core therapeutic areas of hematology, nephrology, neurology, and metabolic disorders. This press release and further information about Alexion can be found at: www.alexion.com. [ALXN-G] Forward-Looking Statement This press release contains forward-looking statements, including statements related to the potential medical benefits of ALXN1210 for the treatment of PNH. Forward-looking statements are subject to factors that may cause Alexion's results and plans to differ from those expected, including for example, the risks and uncertainties of drug development, decisions of regulatory authorities regarding the adequacy of our research, marketing approval or material limitations on the marketing of our products, delays, interruptions or failures in the manufacture and supply of our products and our product candidates, failure to satisfactorily address matters raised by the FDA and other regulatory agencies, the possibility that the current rates of adoption of Soliris in paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), or other diseases are not sustained, the possibility that results of clinical trials are not predictive of safety and efficacy results of our products in broader patient populations, the possibility that clinical trials of our product candidates could be delayed, the adequacy of our pharmacovigilance and drug safety reporting processes, the risk that third party payers (including governmental agencies) will not reimburse or continue to reimburse for the use of our products at acceptable rates or at all, the outcome of challenges and opposition proceedings to our intellectual property, assertion or potential assertion by third parties that the manufacture, use or sale of our products infringes their intellectual property, uncertainties surrounding legal proceedings, company investigations and government investigations, including investigations of Alexion by the U.S. Securities and Exchange Commission (SEC) and U.S. Department of Justice (DOJ), the risk that anticipated regulatory filings are delayed, the risk that estimates regarding the number of patients with PNH, aHUS, gMG, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D) are inaccurate, the risks of changing foreign exchange rates, risks relating to the potential effects of the Company's restructuring and relocation of its corporate headquarters, and a variety of other risks set forth from time to time in Alexion's filings with the SEC, including but not limited to the risks discussed in Alexion's Quarterly Report on Form 10-Q for the period ended September 30, 2017 and in our other filings with the U.S. Securities and Exchange Commission. Alexion does not intend to update any of these forward-looking statements to reflect events or circumstances after the date hereof, except when a duty arises under law.
References1 Hill A, Richards SJ, Hillmen P. Recent developments in the understanding and management of paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2007 May;137(3):181-92. 2 Hillmen P, Lewis SM, Bessler M, et al. Natural history of paroxysmal nocturnal hemoglobinuria. NEngl J Med. 1995 Nov 9;333(19):1253-8. 3 Roeth A, Rottinghaus ST, Hill A, et al. Optimization of Dose Regimen for ALXN1210, a Novel Complement C5 Inhibitor, in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Results of 2 Phase 1b/2 Studies. Poster 3482. December 11, 2017, American Society of Hematology (ASH) Meeting, Atlanta, GA, USA 4 Sheridan D, Yu Z-X, Zhang Y, et al. Design and preclinical characterization of ALXN1210: A next generation anti-C5 monoclonal antibody with improved pharmacokinetics and duration of action. Immunobiology. 2016 Oct 221:1158 5 Sahelijo L, Mujeebuddin A, Mitchell D, et al. First in human single-ascending dose study: safety, biomarker, pharmacokinetics and exposure-response relationships of ALXN1210, a humanized monoclonal antibody to C5, with marked half-life extension and potential for significantly longer dosing intervals. Blood. 2015;126 (23):4777. 6 Lee JW, Bachman E, Aguzzi R, et al. ALXN1210, A Long-Acting C5 Inhibitor, Results in Rapid and Sustained Reduction of LDH With a Monthly Dosing Interval in Patients With PNH: Preliminary Data From a Dose-Escalation Study. Haematologia (Budap). 2016;101(Suppl 1):414-5. 7 Lee JW, Bachman E, Aguzzi R, et al. Immediate, Complete, and Sustained Inhibition of C5 with ALXN1210 Reduces Complement-Mediated Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Interim Analysis of a Dose-Escalation Study. Blood. 2016;128:2428 8 Socié G, Mary JY, de Gramont A, et al. Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. Lancet. 1996;348:573-577. 9 Hill A, Kelly RJ, Hillmen P. Thrombosis in paroxysmal nocturnal hemoglobinuria. Blood. 2013;121:4985-4996. 10 Nishimura J, Kanakura Y, Ware RE, et al. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine (Baltimore) 2004 May;83(3):193-207. 11 Weitz I, Meyers G, Lamy T, et al. Cross-sectional validation study of patient-reported outcomes in patients with paroxysmal nocturnal haemoglobinuria. Intern Med J. 2013;43:298-307. 12 Parker C, Omine M, Richards S, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005 Dec 1;106(12):3699-709. 13 Hillmen P, Muus P, Duhrsen U, et al. Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria. Blood. 2007 Dec 1;110(12):4123-8. 14 Wang H, Chuhjo T, Yasue S, et al. Clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure syndrome. Blood. 2002;100 (12):3897-3902. 15 Iwanga M, Furukawa K, Amenomori T, et al. Paroxysmal nocturnal haemoglobinuria clones in patients with myelodysplastic syndromes. Br J Haematol. 1998;102(2):465-474. 16 Maciejewski JP, Rivera C, Kook H, et al. Relationship between bone marrow failure syndromes and the presence of glycophosphatidyl inositol-anchored protein-deficient clones. Br J Haematol. 2001;115:1015-1022.
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Contact UsHome > Error Code > Windows Xp Install Error 7
Windows Xp Install Error 7
System comes on, but is inadequate and disconnect the DVD drive. And it boots and comes to the done this before. You may find theseof lied, but not really.I'm working with a HP LaserJet 5Si printerwith the 2GB RAM in slot 1.
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