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He conjectured: what if a calculating engine could not only foresee but could act on that foresight. Ada was touched by the "universality of his ideas". Hardly anyone else was.
Author: ebby
Productivity with Emacs
One of the noticing things when working for a startup is the amount of technologies you run into. We at Manetos started out with a minimal tech stack mostly for keeping things simple and easy to fix. But sooner or later we realised that having a small developer team we needed new technologies that give a… Continue reading Productivity with Emacs
If we can empathize with someone, we will know everything they do has a cause and effect. We are all product of our environment and out situation, our thoughts and actions. To empathize is to stand in their shoes for a moment, and to think we could have been them. So we be more kind… Continue reading Empathy
"He transferred pain into beauty like a silkworm" This epitomizes the human spirit, because every hurt around is the thing of the mind, and someone needs to seek and liberate.
Inception Pin Wheel
I had a small take on the concept of pinwheel when fischer discovers in his own subconscious, what made fischer discover this was a thought incepted by cobb in the former stages of the dream, i personally think the pinwheel stands for something that is dependent on something else for it to be what it is,… Continue reading Inception Pin Wheel
back to the university
I had the chance to go back to my university, to get my mark transcripts, and reco letters which turned out to be very useful in other ways. Vinod sir, and benson sir, asked me and dinesh to give juniors in college talks and presentations, and also clear any doubts they have. We spoke with… Continue reading back to the university
Gnome Roadmap for 2.22
The GNOME Roadmap for 2.22 (and partially for 2.24 and future 2.x releases) is available at: http://live.gnome.org/RoadMap To have access to the Roadmap of previous stable releases, go to: http://live.gnome.org/RoadMap/Archive To list a few . The Roadmap for evolution groupware Asynchronous operations support in Evolution Non-intrusive error reporting Smart card support for Exchange Exchange 2007… Continue reading Gnome Roadmap for 2.22


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Thursday, August 13th, 2009
Denmark: 4 Iraqis deported after mass rape of 14 year old girl
Family and friends of four Iraqi rapists went amok in a Danish court (Venstre Landsret), when all four were sentenced to be deported from Denmark for good after serving their sentences.
'Equal Opportunities' © Georghine Sandhi
The four men are all Iraqis living in the city of Odense.
In February they were found guilty of mass raping a 14 year old Danish girl at a local fair; Vorbasse Market June 18 2008. During the horrifying episode the Iraqis took turns, raping the child orally, vaginally and anally. According to her mother this was [...]

subset: commoncrawl


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volunteered them for a battle that
would surely bring them to Glory and honor. He was fully aware that the battle
would not be a success, but it was a success morally. The people finally
learned that blacks were people. This movie was not only about the blacks having
their own regiment, but how they changed the public's views on them, and showed
them that they were humans. ...
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1 1989 34. Journal how to trade forex youtube the American Academy of Child Adoles- cent Psychiatry, 38, 13891395. The ability to estimate and behave according to those tacit rules of appropriateness constitutes a spatial ability that all people acquire during upbringing. (1980). Most investigations to date have sought to develop research designs that can detect and dem- onstrate these effects. How to trade forex youtube are still many possibilities for the design of asymmetric two- Table 11.
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Appl. Hello There); FIGURE 17, 64 For example, KO-42, with 42 amino acid residues, which dimerizes to a four-helix bundle, forming a cluster of six histidine residues, catalyzes the hydrolysis of mono-p-nitrophenyl fumarate and its transesterifi- cation to form the corresponding trifluoroethyl ester in 10 vol trifluoroethanol. Psychologi- cal Review, 80, 417438. The sequence of each new bactcrial genome (with the possible exception of E. Signals for forex θi where a and b demand in the forex market arbitrary constants in θi.
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Mother still had to get up every morning and cheek.474 Levenson, J. 1994) and how different genres of text (news, Ch. Genetic factors likely contribute to the development of EDs, G. Human pride is so curiously good and comforting. Hannah, a seven year old says Its like an iron. Pat. xml (Script 14. The concept of nanochemistry which we are out- lining herein implies four steps (i) design and synthesis of suitable molecules as long as we are not subjecting single molecules to chemi- cal transformations, R.
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Greene, Weissman, Rounsaville, Chevron, 1984). Teasdale, J. All I could think of was that I wanted to pop into her and I was afraid I couldnt. Kernberg (1976) suggested that narcissism declines with age and older patients with NPD can become more treatable in later years of life. Battig, How to trade forex youtube. As monotherapy, during which the acetyl group on the hydroxyl at C21 is simultaneously removed, giving semicarbazone 27.Feldbau-Kohn, S.
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Q. Where more than one equipment grounding or bonding conductor of a branch circuit enters a box, all such conductors shall be in good electrical contact with each other, and the arrangement shall be such that the disconnection or removal of a receptacle, luminaire (fixture), or other device fed from the box will not interfere with or interrupt the grounding continuity. Where is this section found in the 2005 NEC?
Answer: D
Article 551, Recreational Vehicles and Recreational Vehicle Parks, covers the electrical conductors and equipment other than low-voltage and automotive vehicle circuits or extensions thereof, installed within or on recreational vehicles, the conductors that connect recreational vehicles to a supply of electricity, and the installation of equipment and devices related to electrical installations within a recreational vehicle park. Section 551.55(E) focuses on the grounding continuity in the area of interior grounding equipment.
Owen is the owner and president of National Code Seminars and the holder of master electrician certifications in 46 states. He can be reached at [email protected].


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This entry was written in the personal journal of Joseph Smith eleven years after the Word of Wisdom was revealed to the Prophet. Instances like this may surprise some members of the LDS Church who, perhaps, remain unfamiliar with the "line upon line" process in which the Word of Wisdom developed over time. Other members, learning about the relaxed approach to the Word of Wisdom common during the early period of Church history feel history vindicates current disobedience to the Word of Wisdom, as well as other commandments as taught by the Church. Today the Word of Wisdom is taught as a commandment, and a requirement for entry to the temple, though this was not always the case.
Even at Carthage Jail the brethren, according to John Taylor, sent for some wine:
Sometime after dinner we sent for some wine. It has been reported by some that this was taken as a sacrament. It was no such thing; our spirits were generally dull and heavy, and it was sent for to revive us. I think it was Captain Jones who went after it, but they would not suffer him to return.
I believe we all drank of the wine, and gave some to one or two of the prison guards. We all of us felt unusually dull and languid, with a remarkable depression of spirits. In consonance with those feelings I sang a song, that had lately been introduced into Nauvoo, entitled, 'A Poor Wayfaring Man of Grief', etc. (History of the Church, Vol. 7, p.101).
These incidental occurrences are slight in comparison to Joseph Sr.'s struggles with alcohol; an aspect of the prophet's father I was unfamiliar with until I read Richard Bushman's biography of Joseph Smith. Fortunately he seems to have eventually put this habit down.[3]
Outside influences (temperance movements the opinions of physicians etc.) likely helped the Word of Wisdom along. Today it may be claimed that the Word of Wisdom preceded medical knowledge regarding the substances mentioned therein. Some scholars have argued otherwise. For example, in the 1830s temperance societies flourished, including one near Kirtland, helping to shut down a distillery. In New York, a society spearheaded by Sylvester Graham of "graham cracker" fame, spoke out against tobacco, alcohol, tea, coffee and harmful substances. It is very likely Joseph would have been familiar with the movements. Other influences included common physician opinions on temperance in eating habits, etc.[4]
This brings us to 1833 when, in the School of the Prophets, Emma had complained about the smoke-filled room and was tired of cleaning up tobacco juice. She importuned Joseph, who importuned the Lord, and Section 89 was born. [5]
The Word of Wisdom was instituted as counsel and "breaking" (in our modern understanding of the Word of Wisdom) was not extremely uncommon. Still, members of the Church were often called before a High Council over various offenses, the Word of Wisdom among, but not the chief, reasons. One such example was David Whitmer, who was excommunicated based on 5 different charges, one of which was breaking of the Word of Wisdom.
The Journal of Discourses occasionally contains references to the Word of Wisdom. On March 18, 1855 George A. Smith related the story of a particular family who apostatized after seeing what they believed was inconsistency in the application of the Word of Wisdom:
I know persons who apostatized because they supposed they had reasons. For instance, a certain family, after having traveled a long journey, arrived in Kirtland, and the Prophet asked them to stop with him until they could find a place. Sister Emma, in the mean time, asked the old lady if she would have a cup of tea to refresh her after the fatigues of the journey, or a cup of coffee. This whole family apostatized because they were invited to take a cup of tea or coffee, after the Word of Wisdom was given (JD 2:211).
In 1842 a small controversy over part of the Word of Wisdom led to an editorial written at Nauvoo by Hyrum Smith delineating tea and coffee as the specific substances referred to as "hot drinks" (see Times & Seasons, 3:800) indicating that the revelation was still being understood differently by various members of the Church.
The revelation was still seen as 'non-binding' to the Church as the Saints prepared to migrate from Iowa to the Salt Lake Valley in 1847 the Word of Wisdom was still seen as non-binding; on the list of required items for the journey tea and coffee were present. Because of the poor harvest of 1849 in the Salt Lake valley, a regulation prohibiting the use of corn in making whiskey was passed, any corn intended for that use was to be "given to the poor." (Leonard J. Arrington, Great Basin Kingdom: An Economic History of the Latter-day Saints, 1830-1900, p. 59.) By 1850-51 overland travelers headed for the gold in California were stopping off in Utah, where the Saints accommodated them by establishing, or allowing for the establishment, of "a great many grog shops," selling locally brewed whiskey, a "valley tan" rum, green tea, and a "very light and wholesome beer." (ibid., 70).
At a conference of the Church September 9, 1851, John Smith, Patriarch to the Church and uncle of the Prophet, spoke on Word of Wisdom. Brigham Young stood during the address proposing that all Saints abstain from "all things mentioned in the Word of Wisdom."[6] With a "unanimous vote" the Word of Wisdom became binding on the Church. Still, even after that Pres. Young recommended tobacco be grown in the southern part of the territory to eliminate giving money to outsiders for the product, in addition to wine being manufactured in St. George (some for use in the sacrament) as late as 1861. The precise alcoholic content of wine prepared there is not known, as far as I have learned. In the 1860s especially, use of coffee, tea, tobacco, and alcohol were strongly discouraged. In several sermons by Brigham Young he tended to emphasize the economic aspect above the health aspect; using such products, which were usually imported, was wasteful and the money should be better used elsewhere.[7]
For years President Young and others struggled to adhere, and to get all Saints to adhere to the principle. Because the Word of Wisdom took time to implement fully, Brigham encouraged youth not to follow the bad example of those who broke the Word of Wisdom (additionally, he indirectly clarifies the commandment given through Moses, "Thou shalt honor thy father and mother, etc."):
"Why," say you, "I see the older brethren chew tobacco, why should I not do it likewise!"
Thus the boys have taken license from the pernicious habits of others, until they have formed an appetite, a false appetite; and they love a little liquor, and a little tobacco, and many other things that are injurious to their constitutions, and certainly hurtful to their moral character. Take a course that you can know more than your parents. We have had all the traditions of the age in which we were born to contend with; but these young men and women, or the greater part of them, have been born in the Church, and brought up Latter-day Saints, and have received the teachings that are necessary to advance them in the kingdom of God on earth.
If you are in any way suspicious that the acts of your parents are not right, if there is a conviction in your minds that they feed appetites that are injurious to them then it is for you to abstain from that which you see is not good in your parents (July 4, 1854, JD 2:16).
In April 1855 President Young discouraged mothers from using alcohol:
Some mothers, when bearing children, long for tea and coffee, or for brandy and other strong drinks, and if they give way to that influence the next time they will want more, and the next still more, and thus lay the foundation for drunkenness in their offspring. An appetite is engendered, bred, and born in the child, and it is a miracle if it does not grow up a confirmed drunkard (JD 2:266).
In December of the same year, apostle Amasa Lyman, in his typically blunt and animated prose, gave this secret to success regarding the promise in the Word of Wisdom that those who obey will walk and not be weary, run and not faint:
…if you want to run and not weary, walk and not faint, call upon me and I will tell you how-just stop before you get tired…
Elder Lyman said the Word of Wisdom ought to encompass the entire gospel, or that the gospel encompasses it:
The Word of Wisdom was given for a principle, with promise; as a rule of conduct, that should enable the people so to economize their time, and manage and control themselves, as not to eat and drink to excess, or use that which is hurtful to them; that they should be temperate in all things, in the exercise of labor, as well as in eating and drinking. Clothe yourselves properly if you can. Exercise properly if you can, and do right in everything…
Do not stay the work of improvement and reform to pay attention to small things that are beneath your notice, but let it extend through the entire circle of your being, let it reach every relationship in life, and every avocation and duty embraced within your existence…
The Word of Wisdom would itself save you, if you would only keep it, in the true sense and spirit of it, comprehending the purpose for which it was given (JD 3:176).
In 1867 Brigham Young discussed his personal difficulties with the Word of Wisdom::
It is our right and privilege to live so that we may attain to this [being of one heart and mind], so that we may sanctify our hearts before the Lord, and sanctify the Lord God in our hearts, but it is not my privilege to drink liquor, neither is it my privilege to eat tobacco.
Well, bro. Brigham, have you not done it?
Yes, for many years, but I ceased its habitual practice. I used it for toothache; now I am free from that pain, and my mouth is never stained with tobacco. It is not my privilege to drink liquor nor strong tea and coffee, although I am naturally a great lover of tea. Brethren and sisters, it is not our privilege to indulge in these things, but it is our right and privilege to set an example worthy of imitation (JD 12:27).
Indeed, Young returned to chewing after his toothaches came back, until eventually he had them all pulled and wore a set of false teeth for the rest of his life.
It wasn't until about 1921 that Heber J. Grant made observance of the Word of Wisdom a requirement to enter the Temple. Joseph Lynn Lyon surmised the prohibition movement, "spearheaded by the Protestant Evangelical churches in America, focused on alcohol consumption as a political rather than a moral issue," and brought the Word of Wisdom into Church limelight.[7]
Some people I've spoken with express concerns that the Word of Wisdom isn't applied equally in all areas; that more emphasis could be put in the aspects of eating right, exercising, etc. I believe these aspects should be attended to by each individual, but the minimum requirements in the Temple recommend interview stick to the "spirit of the law" as was lived in the early days of the Church. Some early Church leaders put more importance on the issue of eating properly than others. For example, John A. Widtsoe wrote an entire book, The Word of Wisdom: A Modern Interpretation, which contained extensive chapters on diet. What about caffeine? (See FAIR's "Ask the Apologist" selection by Suzanne Armitage regarding caffeine.) What about fad diets? I believe if one must listen to the Spirit, as well as pay attention to one's body, to find the proper balance.[8]
Finally, what's a post about the Word of Wisdom without a J. Golden Kimball anecdote?
Uncle Golden's struggles with the Word of Wisdom sometimes forced him into ironic circumstances. On one occasion, he was asked to go to Cache Valley where the stake president had decided to call all the Melchizedek priesthood holders together for the purpose of emphasizing the importance of the Word of Wisdom. Uncle Golden didn't realize this was going to be the theme until he got there. As a matter of fact, he didn't know what he was to speak about until the stake president announced it in introducing Uncle Golden: 'J. Golden Kimball will now speak to us on the subject of the Word of Wisdom.'
Uncle Golden didn't know what to say. He stood at the pulpit for a long time waiting for some inspiration; he didn't want to be a hypocrite and he knew he had problems with this principle. So finally he looked at the audience and said, 'I'd like to know how many of you brethren have never had a puff on a cigarette in all your life. Would you please stand?'
Well, Uncle Golden related later that much to his amazement most of the brethren in that audience stood. He looked at them for a long time and then said, 'Now, all of you that are standing, I want to know how many of you have never had a taste of whiskey in all your life. If you have, sit down.'
Again, to Uncle Golden's amazement, only a few of the brethren sat down. The rest of them stood there proudly looking at him and then there was a long silence. I guess Uncle Golden thought they looked a little too self-righteous, because his next comment was, 'Well, brethren, you don't know what the hell you've missed' (J. Golden Nuggets, More Words Of Wisdom By James N. Kimball, Sunstone 10:3/41 [Mar. 1985]).
As I discover more sermons regarding the Word of Wisdom I'll continue to add them to this post.
An excellent overview of criticism- as well as the development of- the Word of Wisdom was written by Michael Ash, and can be found on the FAIR website. My post is a very brief sketch of a complex issue.
Source: The Diaries and Journals of Joseph Smith, edited by Scott H. Faulring, Signature Books, Salt Lake City, Utah, 1989, pg. 486
Regarding the wine at Carthage Jail, Lester E. Bush, Jr. refers to a medical opinion of Joseph's day stating that a "moderate quantity of wine" could be helpful in warding off sickness and distress when one is under the "influence of anxious and depressing watchfulness." See Bush, "The Word of Wisdom in Early Nineteenth-Century Perspective," Dialogue 14 (Autumn 1981): 47-65; especially p. 51. Richard Bushman discusses Joseph Sr.'s intemperance:
"The vicissitudes of life seem to have weighed heavily on Joseph, Sr. In a patriarchal blessing given to Hyrum, Dec. 9, 1834, Joseph, Sr., commended Hyrum for the respect he paid his father despite difficulties: 'Though he has been out of the way through wine, thou hast never forsaken him nor laughed him to scorn.' (Hyrum Smith Papers, Church Archives.) Since there is no evidence of intemperance after the organization of the church, Joseph, Sr., likely referred to a time before 1826 when Hyrum married and left home" (Richard L. Bushman, Joseph Smith and the Beginnings of Mormonism, p. 208)
See Lester E. Bush, Jr. "The Word of Wisdom in Early Nineteenth-Century Perspective," Dialogue 14 (Autumn 1981):47-65; Whitney R. Cross, The Burned-Over District, 235; Paul H. Peterson, "An Historical Analysis of the Word of Wisdom," M.A. Thesis, Brigham Young University, 1972, p. 13.
This story regarding the Word of Wisdom in the school of prophets was recounted by Brigham Young, though he was not in attendance at the time, (see JD 12:157-158).
David Whitmer told a slightly different account in a newspaper article 50 years after the meeting.
Quite a little party of the brethren and sisters being assembled in the Smith's house. Some of the men were excessive chewers of the filthy weed, and their disgusting slobbering and spitting caused Mrs. Smith…to make the ironical remark that 'It would be a good thing if a revelation could be had declaring the use of tobacco a sin, and commanding its suppression.' The matter was taken up and joked about, one of the brethren suggest that the revelation should also provide for a total abstinence form tea and coffee drinking, intending this as a counter dig at the sisters. Sure enough the subject was afterward taken up in dead earnest, and the 'Word of Wisdom' was the result (Des Moines Daily News (Des Moines, Iowa), October 16, 1886; as quoted by Peterson, "An Historical Analysis," 20-21, fully notated in 6 below).
It should be noted Whitmer had apostatized at the time of the articles publication, but the general feeling of his statements agree with Brigham Young's account that Emma had some influence in the reception of the revelation.
Zebedee Coltrin, who was present at the school when the revelation was presented, recounted his experience in 1883 when the School of the Prophets was revived by President John Taylor:
When the Word of Wisdom was first presented by the Prophet Joseph (as he came out of the translating room) and was read to the School, there were twenty out of the twenty-one who used tobacco and they all immediately threw their tobacco and pipes into the fire.
According to Coltrin, it took longer for the school to refrain from tea and coffee:
Those who gave up using tobacco eased off on licorice root, but there was not easing off on tea and coffee, these they had to give up straight off or their fellowship was jeopardized. [Coltrin]never saw the Prophet Joseph drink tea or coffee again until at Dixon about ten years after (Source: Minutes, Salt Lake City School of the Prophets, October 3, 1883).
It has been suggested that President Taylor revived the school, in part, to encourage the brethren to obey the Word of Wisdom.
"Minutes of the General Conference," Millennial Star, 1 Feb. 1852, p. 35
Peterson, op. cit. p. 64. A brief online historical sketch of St. George also mentions the wine. See Utah's Dixie History, accessed Sept. 12, 2007. See also the online article by Joseph Lynn Lyon, "The Word of Wisdom," accessed on Jeff Lindsay's Light Planet, September 12, 2007. Leonard J. Arrington discusses the economic aspects in Great Basin Kingdom, p. 223, and in "An Economic Interpretation of the 'Word of Wisdom."' BYU Studies 1 (Winter 1959):37-49.
See "Healthy Outlook: Fad Diets and the Word of Wisdom," by Dr. Stan Gardner. Accessed on the Meridian Magazine site, Sept. 12, 2007.
General Bibliography:
Leonard J. Arrington, "An Economic Interpretation of the 'Word of Wisdom," BYU Studies 1 (Winter 1959): 37-49.
Paul H. Peterson, "An Historical Analysis of the Word of Wisdom," M.A. Thesis, Brigham Young University, 1972.
Lester E. Bush, Jr. "The Word of Wisdom in Early Nineteenth-Century Perspective," Dialogue: A Journal of Mormon Thought 14:3 (Autumn 1981):47-65;
Thomas G. Alexander, "The Word of Wisdom: From Principle to Requirement," Dialogue: A Journal of Mormon Thought 14:3 (Autumn 1981) pp. 78–88.
Clyde Ford, "The Origin of the Word of Wisdom," Journal of Mormon History 24:2 (Fall 1998), 129–54.
Paul H. Peterson and Ronald W. Walker "Brigham Young's Word of Wisdom Legacy," BYU Studies 42:3-4, 2003.
Orig. posted 9/12/2007. Updated and revised 7/2008.


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Click picture for more pictures
Chapel Facade - Close Up
Proto-type Shown. Actual will be in single color to match our injection mold plastic figures
> 27 brand new injection molded Alamo defenders in 8 brand new
poses plus 1 modified pose. Three (3) each of the nine poses are
included in various colors as in our past Alamo sets 1, 2 & 3. The
new poses include a capless frontiersman firing 2
pistols, a Texian clubbing , a Tennessean with long "squaw" coat firing a
rifle, a Texian firing a "scattergun" (I intend to use him for Bowie), 2 dead
Texians, a New Orleans Gray kneeling firing, and a New Orleans Gray - with
alternate arms - who is either firing a pistol or "touching off" a cannon with a
"linstock". The 9th figure is a "redone" Corporal Schiess from our Zulu range
who has had a new arm molded which has him now firing a flintlock pistol instead
of a Martini Henry!!!! (Note: his arm is attached to the sprue containing
the standing firing Tennessean with the squaw coat and feathers on his
> Five (5) new "resin" figures which basically comprise our second "gun crew". These include a gun crew commander (who I envision as one of the Alamo leaders; perhaps John J. Baugh, Travis' "Adjutant" who strangely has been excised from most books and films about the siege.....reportedly, in addition to be Travis' "second", Baugh is also the fella who legend tells us awakened Travis on the morning of March 6, 1836 with the warning cry "The Mexicans Are Coming!"...). The other 4 figures in the gun crew are a mixture of Texians & Tennesseans with an extremely interesting variety of costuming...we intended them all to look as they were prepared to work the guns in earnest …to the last.
Playset 3's Gate building with Painted Metal Figures
(Click picture for larger view)
Copyright © 2006
Conte Collectibles


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Basketry cap, detail of start
Overlay in beige, brown, and black. Design of nested triangles over horizontal brown bands, and a flower-like
motif on the base. Labeled, "Given her by _ H Leox of Klamath after his wife's death. Xmas 1895."
7 x 4 inches - Catalog #2-6866


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The reward for information leading to the arrest and conviction of the gunman who wounded a school police officer in Woodland Hills has been increased to $100,000 with a contribution from the Los Angeles Police Protective League (LAPPL).
Officer Jeffrey Stenroos was shot once in the chest at about 11:40 a.m. Wednesday, and his ballistic vest saved him from serious injury. Authorities have put out a composite sketch of the gunman.
"We are shocked by the attack on Officer Stenroos," according Paul M. Weber, league president. "By adding to the reward fund, we hope to send a message that an attack on any law enforcement officer in Los Angeles is an attack on the entire law enforcement community and will not be tolerated."
The Los Angeles City Council was expected to approve a $75,000 reward today for information leading to the arrest and conviction of the man who shot Stenroos. The LAPPL joined with the Los Angeles School Police Association and the Los Angeles Retired Fire and Police Association in adding $5,000 each, which, along with $9,999.99 from 99¢ Only Stores and 1 cent from Councilman Dennis Zine, brings the reward total to $100,000.


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This exercise is from Austin Kleon's Steal Like An Artist journal. There were empty picture frames and I filled them up with four of my heroes.
Josephine Baker: multi-talented, multi-lingual, fiercely courageous, and magnificently curious
Jane Austen: fundamentally comic, historically significant, and phenomenal storyteller
Mary Magdalene: historically ambivalent, Apostle to the Apostles, and loyal companion
Hildegard von Bingen: hardly know what to say about her because the largeness of her life cannot be contained. For those of you who do not know her... she was a Benedictine abbess, writer, composer, philosopher, Christian mystic, visionary, and polymath. She is considered to be the founder of scientific natural history in Germany.
07 February, 2016
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When it comes to dealing with frozen steam coils Campbell-Sevey won't leave you out in the cold. We offer fast turn-around on replacement parts so your system can get heating again.
Heatcraft steam coils are specifically designed with freeze prevention in mind.
With single-tube coils, the steam supply and condensate return headers and connections are normally at the opposite ends of the coil. Uniform steam distribution to each of the coil core tubes is accomplished through careful header-assembly design. The steam supply connection should be located in the center of the header, with a perforated plate-type baffle located directly behind this connection. Carefully sized orifices are located in each of the core tube entrances into the header.
Dual-tube coils utilize a smaller inner tube, with precisely spaced, directional, orifice-type perforations. This helps to direct condensate flow to the return header. The steam supply, condensate-return headers, and connections may be fabricated in 'same-end' or 'opposite-end' orientation.
Contact Campbell-Sevey for all your commercial and industrial heating, drying and processing application needs. We have the service and expertise to get you what you want when you need it.
Mon, July 16, 2018 @ 10:09 AM
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Roberto Rodriguez directs Pedro Infante in El Seminarista, a drama about a man studying for the priesthood who begins to question himself when he develops a strong attraction for a woman. ~ Perry Seibert, Rovi
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
Copyright © 2019 FANDANGO MOVIES.


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Tuesday, October 26, 2010
10 comments:
- AnonymousOctober 26, 2010 at 2:47 PM
How exciting to be so close! Wowza, 3 days! And knowing the latest date possible!ReplyDelete
I hear you on election ads. I'm so sick of them.
I'm glad I have never had to fire someone. I hope the person at least somewhat knew it was coming.
Three days, woo hoo! Hope your little one is somewhat punctual. =)ReplyDelete
And yes, firing people sucks. I worked in HR for several years, and even when they "deserve it" it sucks... Sorry you had to end things on a bad note.
wow, you're almost there! i hope it happens soon and you can enjoy the whole process...best of luck!ReplyDelete
So exciting that you only have 3 days left!!! Hope the little one shows up soon. I remember the last couple of weeks of begging her to get out. :)ReplyDelete
Holy cow, three days!?! Can't wait :)ReplyDelete
I hope you get a couple days to take naps and spend your days as you please, followed by a healthy and efficient birth! I'm going to borrow your chant and see if it has any effect over here.ReplyDelete
wow. wow. wow. praying for you, friend.ReplyDelete
what a way to go on leave... glad it went better than it might have.
breathe. trust. all shall be well.
I couldn't agree with you more about election season! That sucks having to fire someone. I hope you could shake off the bad feelings soon.ReplyDelete
Happy Due Date!ReplyDelete
(I laughed hard at your GET OUT GET OUT GET OUT)
So sorry that you had to fire someone. It really sucks, even when the person in question totally deserves it. Congrats on being done with work -- I hope that the threatening has its desired effect!!ReplyDelete


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Excerpts from this book.
The Miraculous Mind
of Christ
Jesus' mental processes were miraculous. Ourlibraries are full of books written by great thinkerslike Thomas Edison and others who were incessantthinkers. With Jesus there is something different. Hespoke out from the Spirit that dominated Hisspiritual faculties. The Spirit of Christ ruled Hisintellect. Gems of divine truth dripped from His lipsas honey from the honeycomb. The Sermon on theMount and great portions in Luke and John are asuntouched as when they dropped from the lips of Jesus. Men's writings grow old and out of date. God'struth is ever fresh. Yes, Jesus' words and life andcontact with men were miraculous; they are still miraculous.His death on the cross, His three days in the tomb,His dramatic and startling resurrection, were allmiracles. His presence among the disciples ondifferent occasions and, finally, His ascension in thepresence of five hundred witnesses were miracles.
They do not belong to the reason realm; they belongto the miracle realm. Jesus was in the realm of theSpirit, the realm of faith, the realm where God acts,the realm where the real child of God lives. You see,Christians have been translated out of the realm of human thought and reason into the kingdom of theSon of His love, the realm of the Spirit.
It would be uncharitable if we were to criticize aman of reason who knows nothing about thespiritual realm.
Christianity is not the product of human reasoning. Christianity is a divineintervention. Christians are those who have beenborn from above. They have been re-created. Thislife of God that comes into their spirit naturedominates the reason so that they have "the mind of Christ" (1 Corinthians 2:16) to think God's thoughtsand live in God's realm of miracles.
Friends, when a Christian tries to live by reason, he is moving out of God's country into the enemy's land.
We belong in the miraculous or supernatural realm.
Christ was a miracle. Every Christian is a miracle.
Every answer to prayer is a miracle.
Every divine illumination is a miracle.
The power of Christianityin the world is a miraculous power.
God, help us torealize that ours is a high and holy calling.
Miracles Are For Today
I want to talk to you on the subject of miracles thisafternoon. From the year 400 until now, by and large,the church has assumed the attitude that the days of miracles are passed—without any scripturalevidence whatever. They have taught that miracleswere to demonstrate the divinity of Jesus and that, therefore, the divinity of Jesus having beendemonstrated, there was no longer any need formiracles.
We had a local incident that demonstrates the effectof this teaching. I think my conviction on the matteris that it has done more damage to the Christian faiththan any other teaching that has been promulgated.
There is a gentleman who works at the Davenport Hotel in Spokane, O. A. Risdon, who is one of theengineers there. He had a son with a deformed head.The top of the head raised up like the ridge of a roof; the forehead and back of the head also were forcedout in similar manner, giving the head the appearance of the hull of an upside-down yacht. He was born with what the physicians call a closed head. The boy was always slobbering. The pressure on the brain caused the right side to become paralyzed, and the boy was dumb. He was five yearsold at this time.
The physicians said there was nothing they could do.Then, in desperation, he appealed to his pastor. The pastor told him that the days of miracles were past, that the Lord did not heal now, and that miracles were given to demonstrate the divinity of Jesus. The father replied, "If Jesus would heal my son, I would be convinced that He is divine now. If He is divine,He could lift this damnation from our house.
"Finally, he came to us seeking help. We began tominister to the child. In a few days, we observed that the paralysis began to depart. Instead of walking onone side of his ankles, he began to walk on the foot, and that indicated that the pressure was relieved onthe brain. In seven weeks, the child was perfectly well. The bones of the head softened and came downto normal. The paralysis disappeared, and the child began to talk. In three months, he was in the publicschool. He is a young married man now.
Dear friends, if we had continued to believe that the days of miracles were past, that boy would be in the insane asylum. But we believed that Jesus Christ is the same yesterday, today, and forever, and the boy was healed.
It is a delight to believe the words of Jesus. I have used this rule in my study of the Scriptures. If there is any question on any Scripture, I settle it with the words of Jesus. I consider all the Scriptures are a common court of the gospel, but the words of Jesus are the Supreme Court of the gospel.
When I want a Supreme Court decision, I appeal to the words of Jesus.
You can read all the words of Jesus in two hours or less in a red-letter New Testament. Make a practice of reading the words of Jesus on any subject that troubles you, and make a compilation of what He says.
He ought to be sufficient authority on any question, for the heavenly Father called attention to the fact that He is the Son of God and that we are to hear Him. God declared:
This is my beloved Son, in whom I am wellpleased; hear ye him. (Matthew 17:5)


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Dr. Ben Carson, the author of "One Nation: What We Can All Do to Save America's Future," told Jake Tapper on CNN's "The Lead" on Thursday that National Prayer Breakfast organizers demanded an apology from Carson after his now famous keynote speech at the 2013 National Prayer Breakfast.
Carson said that after the speech, Obama "thanked me for coming and speaking."
Carson then stated about 15 minutes after the speech, the organizers of the event told him "that the White House was very upset and that I needed to call the president and apologize." Carson said that he responded by saying he "get the impression that [Obama] was very upset," and so an apology was unnecessary.
Follow Ian on Twitter @IanHanchett


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the béchamel on my moussaka did not 'set' after an hour of baking? Why?
Was the end result too liquid? Bechamel should be cooked to a fairly thick consistency before using in moussaka or lasagna.
Agreed--if you cook the béchamel in a saucepan, whisking all the while, it should thicken up nicely. What béchamel recipe are you using?
Do you have the Joy of Cooking? The Moussaka recipe in it uses a yogurt-egg mixture that doesn't require pre-cooking and is lighter than béchamel. A nice change that really compliments moussaka well.
Beschamel for Italian cooking is a sauce that does not contain eggs. When I purchase moussaka from a local vendor (I keep pieces of it as a go-to frozen item that I can defrost and reheat quickly in emergencies.)
it def has egg in it, which firms it up as the top layer and makes is cuttable, so I suggest you look for recipes containing egg.
I just googled Moussake Recipes and here is the first one I chose. yes it contains egg.Does yours? if not, add egg to your sauce, in the same ratio as in the majority of recipes you find.
It wouldn't really hurt the moussaka to pour over a new, 2nd, beschamel layer, containing egg this tie, and bake it til it sets up.But maybe accept yours as it is this time and use the new knowledge for future moussaka.
sorry, here is s sample egg containing beshamel recipe for moussaka specifically.
I do wish there were an edit feature for our responses! What I should have been saying is that the thing you refer to as a 'beschamel' in your question- is not a true beschamel.I don't think (most or all)Greeks call it a beschamel either. It is a custard: butter, thickener(flour), milk, egg. This is the from a Food Network Moussaka recipe:
5 tablespoons unsalted butter
6 tablespoons all-purpose flour
3 cups whole milk, room temperature
1 1/2 teaspoons kosher salt
Pinch of ground nutmeg
1 large egg
2 large egg yolks
1/2 cup dried breadcrumbs
3 tablespoons Pecorino Romano


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"Southern France", I say, and I can see the immediate effect- either this guy's got "brass" - "scudos" or he's lying!
Well, actually - neither! I live here - far from the madding crowd of Tourists, although the Meditteranean is only 10 miles away, or so, and Tourists, mainly lost, do pass through!
|Yes - I live in the South of France, but I have little to do with the typical tourist occupations!
|My life is more that of the typical pensioner who has to live SOMEWHERE, and park benches are quite all right, by me!
|And - yes, there are some traditions which are agreeable, because they're not only traditions, but can be seen day in, day out!
They're for Tourists!
Since you have to live somewhere, why not choose the South of France instead of Grimsby....?
At least the heating costs are less, although nowadays the Air-Conditioning is taking over, and Summers become as expensive as Winters for the reverse - Cool down instead of warm up!
People always seem to assume Richness with the South of France, and it is exactly the same as elsewhere. http://en.wikipedia.org/wiki/Southern_France
There is EXCESSIVE richness, but also EXCESSIVE poverty. Nothing is spared, except the perpetual 40 days and 40 nights of dripping rain!
|(I only see a beach once a year, and not every year either!)
It doesn't happen often, and I'm glad to have my permanent small Pension, thanks to the German authorities. If I hoped for things from the British Government, I could hope in extreme vain, in spite of my history of serving "Her Royal and Gracious Majesty" for years, so that other people in their own little corners of a far flung land could advance in their jobs, and finally have their little 2 up and 2 down - or more, protected of course, by their serving military, who they consider as "idiots" and "dispensible" - once they've done their job! That's probably why I have so little to do with such people - anywhere - even including my own family, in their own little worlds.
|This is the type of "home" people associate with me. Actually, there are only tourists who have such things....!
Oh - hell - I'll leave them in their little worlds.......I'm off to the pool.....in my boat!
|Boat was mine - the Sea is public.....!
|(in the background the village of Meze, Herault.- with something on fire!)


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Happy Handle Coffee Cozy Video Tutorial
Tutorial by MooglyAdd to Favorites
Full Description
The Happy Handle Coffee Cozy makes a great gift – fun to make and use, and sized so a gift card slips right in the handle to put an extra big smile on their face! And as a reader request, it how has a video tutorial! Here's how to crochet the Happy Handle Coffee Cozy!
Error, group does not exist! Check your syntax! (ID: 2)
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love spell I will help you to restore your broken relationship (310) 610-5949
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I've been a little confused.
How common a name is Armintrout?
doesn't seem like it's that common, right?
I kept seeing these posts about this new series - the Lux series, and thinking they were by Jennifer Armintrout, of American Vampire fame - until I read some author bio about how the author lives in West Virginia.
Huh? (I thought)
I could have sworn that she lives in Michigan.
Apparently there are TWO Jennifers with very similar last names.
Jennifer Armintrout;
and then there is Jennifer L Armentrout who also writes under the name J. Lynn.
Confused? I am/was. It's not helped by the fact that they BOTH write adult AND YA novels.
My question - How can there be two last names that not only are so quirky sounding, but so very similar; and how can they ALSO have the very same first name? Talk about coincidence - this is a hell of a coincidence. I almost thought they might be the same person, using pen names, but they live in different states,which is what first clued me in to the fact that these were in fact not the same person.
Jennifer Armintrout, also known as Abigail Barnette - is the Jennifer that I first read, the one I thought both Jennifers were - writes the Blood Ties series (I've read the first of the series - The Turning - and wouldn't mind reading the second), and also a young adult series (Lightworld/Darkworld novels) including the Queene of Light; she writes a blog titled Sweaters for Days. She is delightfully outspoken.
(god, I sounded old right there)
Her twitter account is @JArmintrout;
'devourer of heads',
'part-time lady'
'servant of Morgoth'
and includes the info that she DOES NOT have a brain tumor (caps are from me)
I don't do twitter, so I don't usually pay attention to twitter info - but I do like her self-descriptions. How can you not?
love humor like this.
The other Jennifer is Jennifer L. Armentrout, she also writes as J.Lynn, who lives in West Virginia and writes YA novels - The Lux series, including Obsidian. Her J. Lynn pen name writes adult novels. Jennifer L. Armentrout writes a blog and has a twitter account which, of course, sounds very similar to the above Jennifer, @JLArmentrout.
Cool thing - the Lux series is about ALIENS, i.e., SciFi - so that actually is enough to make me want to read it, even though it's YA. I've mentioned before, that I rarely read YA, unless it's by an author that I've already read and loved (i.e. Lilith Saintcrow writing as Lili St. Crow) or by an author that I've already grown to like and respect (i.e. J.A. Campbell). But once in a while...a YA novel rears it's little YA head and catches my interest. After all, sometimes it just feels a little off to be reading YA with all the little YA issues, the super young characters, and the emotional YA angst that can rear their little YA emo heads. I know that sounded a little negative, but I didn't mean it too. It's just a bit of a stretch at times, to read about very young people when you are rounding the corner into older age, dealing with hot flashes, changing body, joints that MAKE NOISE when you move, etc. ;) But when I read fiction by Lili St. Crow or J.A. Campbell, the characters go a bit beyond the usual or perceived young brain emo/issues/thoughts/problems.
I took a quick read of Obsidian and judging by some of the pages I was able to read, this one is going to be interesting - hello, ALIENS = SciFi + enemies from yet other planets = great reading fun!
Geez - no wonder I was confused!
All this time - ever since the first Lux novel came out, I really thought they were from the same lady! I've heard of authors with the same name as others before, of course there is going to be some with the same name - but two names with just one letter different, in addition to the very same first name?
After reading a sample of two of the Lux series, I'll probably end up getting a hold of a copy of them. Though in high school, the characters don't sound like fluffy high school characters, but like older teens going through some major issues - life and death issues (alien invasion, hunting, enemies....) - enough to keep me interested.
And while researching the difference between these two writers, I also was able to read a sample of Jennifer Armintrout's recent American Vampire novel - sounds similar to Rachel Caine's Morganville setting - a town where no one leaves, but it's a bit difference. I put it on my wish list at Amazon (which I forget to update regularly, haha)
I think this is enough rambling for now - laters, y'all


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Little Miss Lilly Bee, by Esther Rose
Immediate Download
Download this title immediately after purchase, and start reading straight away!
Give an Ebook Gift Voucher
Want to buy a great gift for a special someone? Buy them an Ebook Gift Voucher.
Little Miss Lilly Bee is a read-aloud ebook designed for the Apple iPad iBooks application.
The book is narrated by the author, and the reader can choose to have the story read to them (with the words being highlighted in time with the narration), or they can read it by themselves.
Little Miss Lilly Bee is a appealing little story for young children that'll make them want to read it over and over again.


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This week's Classical Break takes as its theme, Dance and Drama. It's a repeat (slightly re-edited) of a programme that was transmitted back in May 2010 - so we hope you will have forgotten what it was like and look forward to your texts and messages! It was written and presented by Rupert Kirkham.
Mike Burrows is working on the next 2 scripts for Classical Break - an analysis of Rachmaninov's First Symphony and another special he won't tell me about....
From next week, we are offering a 'listen again' service to Somer Valley listeners. This means that you won't have to wait up till 0100 on a Monday morning to catch the repeat of Classical Break - you will be able to listen to it at your convenience for up to 3 weeks after the programme has gone out on Somer Valley FM.
This means that in the future, whilst there will be fewer repeats on air - to make room for more original programmes - if you miss a show, ou have up to 3 weeks to listen to it at your convenience.
It's all part of 2012's new and improved Somer Valley FM that you have helped to create!
PS Please let us know what you think about this new service - and anything else about Classical Break or any of the shows that go out on Somer Valley FM. Sometimes it's hard to know if we are doing what you want!


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- Research
- Open Access
Efficacy and tolerability of a new formulation of artesunate-mefloquine for the treatment of uncomplicated malaria in adult in Senegal: open randomized trial
© Tine et al.; licensee BioMed Central Ltd. 2012
- Received: 6 July 2012
- Accepted: 21 November 2012
- Published: 12 December 2012
Prompt treatment of malaria attacks with arteminisin-based combination therapy (ACT) is an essential tool for malaria control. A new co-blister tablet of artesunate-mefloquine (AM) with 25 mg/kg mefloquine has been developed for the management of uncomplicated malaria attacks. This non-inferiority randomized trial, was conducted to evaluate the efficacy and safety of the new formulation of AM in comparison to artemether-lumefantrine (AL) for the treatment of acute uncomplicated Plasmodium falciparum malaria in adults in Senegal.
The study was carried out from September to December 2010 in two health centres in Senegal. The study end points included (i) PCR corrected adequate clinical and parasitological response (ACPR) at day 28, (ii) ACPR at days 42 and 63, (iii) parasites and fever clearance time, (iv) incidence of adverse events and patients biological profile at day 7 using the WHO 2003 protocol for anti-malarial drug evaluation.
Overall, 310 patients were randomized to receive either AM (n = 157) or AL (n = 153). PCR corrected ACPR at day 28 was at 95.5% in the AM arm while that in the AL arm was at 96.7% (p = 0.83). Therapeutic efficacy was at 98.5% in the AM arm versus 98.2% in the AL group at day 42 (p = 1). At day 63, ACPR in the AM and AL arms was at 98.2% and 97.7%, respectively (p = 0.32). The two treatments were well tolerated with similar biological profile at day 7. However, dizziness was more frequent in the AM arm.
Artesunate-mefloquine (25 mg/Kg mefloquine) is efficacious and well-tolerated for the treatment of uncomplicated P. falciparum malaria in adult patients.
- Malaria
- Mefloquine
- Falciparum Malaria
- Artesunate
- Uncomplicated Malaria
Malaria remains a major public health problem in tropical regions. According to the World Health Organization (WHO), in 2010 there were an estimated 149 to 274 million cases and 537,000 to 907,000 deaths worldwide[1]. Over 86% of these deaths occur in children under five years of age[1]. The development and spread of multidrug-resistant Plasmodium falciparum, particularly for the previous main anti-malarial drugs, such as chloroquine and sulphadoxine-pyrimethamine, has affected efforts to control malaria, and can lead to an increase in malaria mortality and morbidity if ineffective drugs remain the standard of care after drug-resistant strains become established. To deal with the threat of resistance of P. falciparum to monotherapies, combinations of anti-malarial drugs are now recommended by the WHO.
Artemisinin-based combination therapy (ACT) is widely promoted as a strategy to counteract the increasing resistance of P. falciparum to anti-malarial drugs, prevent disease transmission and reduce the risk of drug resistance[2–4]. ACT can rapidly reduce the parasite biomass, and may also prevent transmission of P. falciparum by acting against gametocytes[5, 6]. Several formulations of ACT are currently available for the treatment of uncomplicated malaria. A co-blister tablet formulation of artesunate-mefloquine (Artequin®) has been developed by Mepha Ltd and was initially used on the basis of 750 mg mefloquine, which represents 15 mg/kg mefloquine per treatment. Studies in Asian countries showed that artesunate-mefloquine (AM) is effective and safe for the treatment of uncomplicated malaria[7]. In Africa, several studies demonstrated its efficacy and tolerability[8, 9]. However, the dosage of 15 mg/kg mefloquine base is below the posology recommended by the WHO (25 mg/kg mefloquine), to avoid resistance to mefloquine. As a line extension of the co-blister tablet, a co-formulation of AM was developed for the treatment of paediatric patients. Following a recent change in recommendations of WHO for areas of high malaria transmission, the total mefloquine dosage in the co-blister tablet formulation and the novel paediatric formulation was increased to 25 mg/kg body weight[2]. Although the paediatric co-formulation was safe and effective in children less than 5 years[10], studies aiming at evaluating the new co-blister in adults patients have become relevant in the context of scaling up anti-malarial drugs in African countries, in order to continue to monitor adverse drug reactions as well as drug efficacy. The aim of this study was to compare the clinical and parasitological efficacy, as well as the clinical safety, laboratory profile, of a new formulation of artesunate-mefloquine (AM) (25 mg/kg mefloquine base) compared to artemether-lumefantrine (AL) for the treatment of uncomplicated P. falciparum malaria in adults in Senegal.
Study area and population
The study was carried out from September to December 2010 in the two health centres of Guediawaye (20 km from Dakar, the capital city), and Kaolack, 200 km from Dakar (Senegal). Malaria transmission in the two sites is highly seasonal with a transmission peak from September to December. Plasmodium falciparum is the predominant parasite species and transmission is mainly due to Anopheles gambiae s.l. (Konate et al. unpublished data).
Adult patients with acute uncomplicated P. falciparum malaria seen at study sites with parasite density ranging from 1,000 to 100,000 parasites/μL, and presence of an axillary temperature >37.5°C or history of fever during the previous 24 hours, were included in the study. Patients were excluded if they had signs of severe malaria such as convulsions, severe anaemia, respiratory distress, jaundice, haemoglobinuria or/and had a history of allergy to the study drugs. Informed consent was required prior to each study participant enrolment.
Study design
The study was designed as an open randomized, non-inferiority trial with two parallel groups, comparing three-day regimens of AM versus AL. The primary end point was represented by the PCR corrected adequate clinical and parasitological response at day 28. Secondary end points were represented by (i) adequate clinical and parasitological response at days 42 and 63, (ii) parasites and fever clearance time, (iii) incidence of adverse events in the two groups, (iv) patients' biological profile at day 7 in the two groups.
Patients in the AM arm received one tablet of artesunate (200 mg) and one tablet of mefloquine (500 mg) everyday for three days, representing a total dose of 600 mg of artesunate and 1,500 mg of mefloquine. In the AL arm, patients received four tablets twice daily for three days. Each tablet of AL contains 20 mg of lumefantrine and 120 mg of artemether. Treatment doses were administered at health centres under the supervision of the study physician. In the event of a patient vomiting within 30 minutes of tablet intake, the dose was repeated. In the event of a second vomiting episode, the patient was withdrawn and received quinine in accordance with the national malaria control programme guidelines.
Data collection
The WHO 2003 protocol for anti-malarial drug efficacy evaluation was used in this study[11]. After inclusion, patients were evaluated every day during treatment (days 0, 1, 2), on day 3 and at follow up on days 7,14,21, 28. In a subgroup of randomly selected study participants (representing 30% of the total sample), the follow up was extended at days 42 and 63 to assess the long term protective effect of each drug after curative doses. During each scheduled visit, patients were interviewed and examined by the study physician to assess their clinical conditions as well as adverse events. All signs noted during the interview and clinical examinations were reported on a case reported form (CRF). Thick and thin smears were performed at each scheduled visit; four drops of blood were collected on filter paper at Day 0 and at day of recurrent parasitaemia for genotyping in order to distinguish recrudescence from new infection.
Laboratory methods
Thick and thin smears
Blood samples were collected using finger prick blood. Thick and thin smears were stained with Giemsa. Parasite density was determined by counting the number of asexual parasites per 200 white blood cells, and calculated per μL using the following formula: numbered parasites × 8,000/200 assuming a white blood cell count of 8,000 cells per μL. Absence of malaria parasite in 200 high power ocular fields of the thick film was considered as negative. The slide readers were kept blinded to the treatment allocated and day of visit.
Haematological and biochemistry analysis
Haematological and biochemical tests were performed at enrolment and at Day 7 to evaluate haemoglobin concentration, creatinine, aspartate amino transferase (ASAT), alanine aminotransferase (ALAT), and bilirubin concentration. Biological abnormalities were noted.
Primer sequence and polymerase chain reaction (PCR) program for MSP1 and MSP2 amplification
Primer sequence
PCR program
msp 1 primary
94°C-3 min, [94°C-25 sec, 50 °C-45 sec, 68°C-2 min] × 30, 72°C-3 min
msp 1 nested
94°C-3 min, [94°C-30 sec, 50 °C-45 sec, 68°C-2 min] × 30, 72°C-3 min
msp2 primary
94°C-3 min, [94°C-30 sec, 42′C-60 sec, 65°C-2 min] × 30, 72°C-3 min
msp2 nested
94°C-3 min, [94°C-30 sec, 50 °C-60 sec, 72°C-2 min] × 45, 72°C-3 min
The difference in fragment size between pre-treatment and post-treatment samples allows a classification in three categories: new infection if the fragment sizes are different, recrudescence if the fragment sizes are similar, and both recrudescence and new infection if two fragments are visualized in the post-treatment sample with one similar to the pre-treatment fragment. The last two are considered as recrudescence for the analysis[13].
Statistical methods
The number of subjects to be included in this study was calculated using STATA-11™ software, based on an expected therapeutic efficacy of AL at 98%[8] assuming a non-inferiority margin of 7% and 80% of power, using a 95% confidence level, sample size for each arm was evaluated at 160 patients. Data were entered in Excel™ software and analysed using STATA-11™ software. Characteristics of all patients included in the study were tabulated by study arm. For categorical data, percentage was used to assess the frequency of each outcome. For continuous data, mean and standard deviation were used to describe normally distributed variables; otherwise median and range were used. For the primary end point of adequate clinical and parasitological response at day 28, analysis was done by intention to treat and per protocol. The intention treat analysis included all randomized patients, while in the per protocol analysis, patients who were not seen at day 28 were excluded. The ACPR at day 28 was calculated for each study arm and compared using chi square test. The cumulative incidence of failure rate was calculated in each study arm and compared using Kaplan Meir method. For the ACPR at days 42 and 63, analysis was done by per protocol and comparison was made in a similar way.
The frequency of adverse events was described in terms of proportion in each study arm. For some adverse events such as dizziness, analysis was adjusted by haemoglobin level at inclusion, gender, age group and study arm. A stepwise logistic regression was done for the determination of factors associated with dizziness. Significance level of tests was set on 0.05 two side.
Ethical considerations
The protocol was reviewed and approved by the Conseil National de Recherche en Santé (CNRS), which is the Senegalese national ethics committee. On the field, informed consent was requested from all participants prior to their enrolment.
Baseline characteristics
Baseline characteristics of patients at enrolment in the two groups
Artesunate Mefloquine (n = 157)
Artemether Lumefantrine (n = 153)
p value
Age (mean ± SD, years)
25 ± 11
23.2 ± 10,5
Weight (mean ± SD, Kg)
62.1 ± 11.8
58.2 ± 11.5
Sex ratio (male/female)
Temperature (mean ± SD)
37.8 ± 1.2
37.7 ± 1.1
Median Parasitemia (trophozoites/μL)
Mean haemoglobin (g/dl)
12.2 ± 1.7
11.7 ± 1.7
Anaemia (Hb < 11 g/dl,%)
ASAT (UI/L, mean ± SD)
31.2 ± 18.7
33.1 ± 16.8
Patients with normal level of ASAT (ASAT < 40 UI/L) (%)
128 (81.5%)
123 (80.4%)
ALAT (UI/L, mean ± SD)
28.2 ± 20.3
26.3 ± 24.1
Patients with normal level of ALAT (ALAT < 40 UI/L) (%)
119 (82.1%)
138 (90.2%)
Creatinine (mean ± SD)
7.6 ± 5.4
8.2 ± 3.5
Patients with normal level of creatinine (<13 mg/L) (%)
148 (94.3%)
143 (93.5%)
Median Bilirubunemia (mg/L)
Patients with normal level of Biliribunemia (<10 mg/L) (%)
48 (30.6%)
55 (35.9%)
Treatment efficacy
Therapeutic efficacy of AM and AL at days 28, 42 and 63 in adult patients in Senegal – IIT and PP analysis
Artesunate Mefloquine (n = 157)
Artemether Lumefantrine (n = 153)
p value
Intention to treat analysis
Early treatment failure
6 (3.82%)
4 (2.61%)
Crude Parasitological failure at day 28
1 (0.64%)
4 (2.61%)
PCR adjusted failure rate
1 (0.64%)
1 (0.65%)
PCR adjusted cure rate at day 28
150 (95.54%)
148 (96.73%)
Artesunate Mefloquine
Artemether Lumefantrine
Per protocol analysis
Early treatment failure
Crude parasitological failure
1/151 (0.66%)
4/149 (2.6%)
PCR adjusted failure rate
1/151 (0.66%)
1/149 (0.67%)
PCR adjusted cure rate at day 28
150/151 (99.34%)
148/149 (99.33%)
Crude parasitological failure at day 42
2/70 (2.8%)
5/57 (8.7%
PCR adjusted ACPR at day 42
69/70 (98.5%)
56/57 (98.2%)
Crude parasitological failure at day 63
4/57 (7%)
6/44 (13%)
PCR adjusted ACPR at day 63
56/57 (98.2%)
43/44 (97.7%)
For the 104 patients, representing 30% of the total sample, (57 AM arm and 57 AL arm) seen at day 42, the PCR adjusted ACPR was 98.5%% and 98.2%, respectively, in the AM and AL groups (Table3). Overall, 57 patients in the AM arm and 44 patients in the AL arm attended the day 63 visit. PCR adjusted ACPR at day 63 was evaluated at 98.2%% in the AM arm versus 97.7% in the AL arm (p = 1) (Table3).
The decrease of fever was similar in the two treatments groups. Following the first treatment dose (at day 0), 2.6% of patients in the AM arm were found with fever (temperature >37.5 °C) while 5.3% of patients in the AL arm were febrile after the first treatment day (p = 0.25). At day 2, all patients both in the AM arm and AL were found without fever.
The two treatments resulted in a rapid clearance of parasites. The mean parasitaemia at enrolment was 17,411 trophozoites/μL in the AM group and 17,688 in the AL group. It decreased to 864 trophozoites/μL in the AM group versus 949 trophozoites/μL in the AL group, 24 hours after the first dose (p = 0.28). Complete parasite clearance was obtained at Day 2 in the two treatment arms.
Safety and tolerability
Incidence of adverse events in the two study groups from inclusion to day 7 of follow up
Day 1
Day 2
Day 3
Day 7
Adverse event
Dizziness (n,%)
35 (22.3)
17 (11.1)
61 (38.8)
8 (5.2)
58 (38.1)
11 (7.1)
15 (10.2)
6 (4.03)
Vomit (n,%)
16 (10.2)
11 (7.2)
09 (5.7)
04 (2.6)
Abdominal pain
15 (9.5)
11 (7.2)
11 (7.2)
10 (6.5)
10 (6.5)
4 (2.6)
1 (0.66)
Pruritus (n,%)
2 (1.3)
1 (0.6)
Oral herpes (n,%)
2 (1.3)
3 (1.9)
1 (0.66)
3 (1.9)
1 (0.67)
Frequency of dizziness by study group adjusted by gender, age, anaemia at inclusion
Day 1
Day 2
Day 3
n (%)
aOR** (95%CI)
p value
n (%)
aOR (95%CI)
p value
n (%)
aOR (95%CI)
p value
AL (n = 153)
17 (11.1%)
8 (5.2)
11 (7.1)
AM (n = 157)
35 (22.3%)
2.2 (1.1-4.4)
61 (38.8)
12.5 (5.5 – 28.1)
58 (38.1)
10.2 (4.7-22.3)
Patients' biological profile at day 7 post treatment
p value
Day 7
Day 7
Mean haemoglobin
11.3 ± 1.8
10.6 ± 1.5
Anaemia (%)
86 (54.7%)
105 (68.6%)
Median ALAT
Median ASAT
Patients with ASAT < 40 (%)
143 (91%)
139 (90.8%)
Patients with ALAT < 40 (%)
146 (92.9%)
145 (94.7%)
Mean creatinine
7.7 ± 4.7
8.2 ± 7.0
Patients with normal level of creatinine (%)
149 (94.9%)
150 (98.0%)
Median bilirubin
Patients with normal level of bilirubin (%)
92 (58.6%)
82 (53.6%)
Prompt treatment of malaria attacks with effective anti-malarial drug combination is an essential tool for malaria control. Malaria attacks treatment requires the use of artemisinin-based combination therapy (ACT). This non-inferiority randomized trial, evaluated the efficacy and safety of a new formulation of AM with 25 mg/kg mefloquine in comparison to AL. Results from this trial indicated that AM is as effective and well-tolerated as AL for the treatment of acute uncomplicated P. falciparum malaria in adults' patients. Indeed, the PCR corrected ACPR at day 28 was 95.5% in the AM arm as against 96.7% in the AL arm; similar results were obtained in the per protocol analysis with a PCR corrected ACPR at 99.3% and 97.3%, respectively, in the AM and AL group.
These findings are consistent with data described in other trials conducted in African countries. Faye et al. in Senegal obtained a cure rate of 96.2% at day 28 when AM was administrated to children less than five years in a three-day treatment course[10]. Toure in Côte d'Ivoire reported a cure rate of 96% at day 28 for AM and 92% for AL[14], while Sowunmi et al. reported a therapeutic efficacy at 97% for AM and 94% for AL at day 28 in Nigerian children[15]. In patients seen at days 42 and 63 of follow up, PCR adjusted cure rate was evaluated at 98.5%% at day 42 and 98.2% at day 63 for AM group while that for the AL arm was at 98.2% at day 42 and 97.7% at day 63. Thus, the two treatments were highly effective at day 42 and 63 of follow up. Pharmacokinetics studies have demonstrated the long half-life of mefloquine and its ability to reduce rates of reinfection[16]. However, due to the low number of patients seen at day 42 and day 63, the study has lacked of power at day 42 and 62. Further studies with larger sample size would thus provide additional evidence on the long- term effect of mefloquine.
The two treatments were effective in reducing the parasite biomass as well as fever[5, 6]. Thus, on day 2 a complete fever clearance was obtained in the two groups. Similarly, all study participants had a complete parasite clearance at day 2.
The two treatments were well tolerated with a similar safety profile. No serious adverse event was reported during the trial. However, dizziness was more frequent in patients treated with AM. The risk of dizziness in patients treated with AM was dose-related. Indeed, an increase risk was observed after each treatment course (aOR at day 1 = 2.3, aOR at day 2 = 12, aOR at day 3 = 10). Several reviews have published data on the neuropsychiatric effects of mefloquine. In more than 25,000 patients involved in about 20 trials, dizziness and anxiety were the most commonly reported adverse events in adult patients[17–19] as well as vomiting, especially in young children[20–22]. However, despite the frequency of dizziness during the study, no major biological disorder was noted in the study participants and therapeutic efficacy remains good in the two treatment groups. The use of the new formulation of AM should be combined with regular counselling in order to improve patient's compliance.
The new formulation of artesunate-mefloquine (25 mg/Kg mefloquine) is efficacious and well-tolerated for the treatment of uncomplicated P. falciparum malaria in adult patients.
We acknowledge the medical officers of Kaolack, Guediawaye and their teams for their diligent help during this study. Our thanks also go to people for their participation and cooperation in this study. The investigations were financially supported by Pharmaceutical Company MEPHALTD. They also supplied the anti- malarial drugs used for this study.
Authors' Affiliations
- WHO: World Malaria Report. 2011, Geneva: World Health OrganizationGoogle Scholar
- WHO: Guidelines for the treatment of malaria. 2010, Geneva:WHO Press, Second,Google Scholar
- WHO: Guidelines for the treatment of malaria. 2006, Geneva: World HealthOrganization,Google Scholar
- WHO: Antimalarial drug combination therapy: Report of a WHO Technical Consultation. 2001, Geneva: WHO PressGoogle Scholar
- White NJ, Olliaro PL: Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malaria. Parasitol Today. 1996, 12: 399-401. 10.1016/0169-4758(96)10055-7.View ArticlePubMedGoogle Scholar
- Price RN, Nosten F, Luxemburger C, ter Kuile FO, Paiphun L, Chongsuphajaisiddhi T, White NJ: Effects of artemisinin derivatives on malaria transmissibility. Lancet. 1996, 347: 1654-1658. 10.1016/S0140-6736(96)91488-9.View ArticlePubMedGoogle Scholar
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- Faye BNJ, Dieng Y, Faye O, Gaye O: Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal. Malar J. 2006, 6: 80-View ArticleGoogle Scholar
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- Faye B, Ndiaye JL, Tine R, Sylla K, Gueye A, Lo AC, Gaye O: A randomized trial of artesunate mefloquine versus artemether lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Senegalese children. Am J Trop Med Hyg. 2010, 82: 140-144. 10.4269/ajtmh.2010.09-0265.PubMed CentralView ArticlePubMedGoogle Scholar
- WHO: Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. Geneva: World HealthOrganization, WHO/HTM/RBM/2003.50,Google Scholar
- Collins WJ, Greenhouse B, Rosenthal PJ, Dorsey G: The use of genotyping in anti-malarial clinical trials: a systematic review of published studies from 1995–2005. Malar J. 2006, 5: 122-10.1186/1475-2875-5-122.PubMed CentralView ArticlePubMedGoogle Scholar
- WHO: Methods and techniques for clinical trials on antimalarial drug efficacy: genotyping to identify parasite populations: Informal consultation organized by the Medicines for Malaria Venture and cosponsored by the World Health Organization, 29–31 May 2007. 2008, Amsterdam, The Netherlands: WHO,http://whqlibdoc.who.int/publications/2008/9789241596305_eng.pdf%5D,Google Scholar
- Toure OA, Kouame MG, Didier YJ, Berenger AA, Djerea K, Genevieve GO, Penali LK: Artesunate/mefloquine paediatric formulation vs. artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum in Anonkoua koute, Côte d'Ivoire. Trop Med Int Health. 2011, 16: 290-297. 10.1111/j.1365-3156.2010.02701.x.View ArticlePubMedGoogle Scholar
- Sowunmi A, Gbotosho GO, Happi C, Okuboyejo T, Folarin O, Balogun S, Michael O: Therapeutic efficacy and effects of artesunate-mefloquine and mefloquine alone on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in southwest Nigeria. Am J Trop Med Hyg. 2009, 81: 979-986. 10.4269/ajtmh.2009.09-0394.View ArticlePubMedGoogle Scholar
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This material must not be used for commercial purposes, or in any hospital or medical facility. Failure to comply may result in legal action.
Exanthem Subitum
- Exanthem (eg-ZAN-them) subitum, also known as roseola (ro-ZE-o-lah) infantum, is an infection caused by a virus (germ). This condition is common in children two years of age and younger. It is usually caused by the human herpesvirus type 6. These viruses may come from other children or adults with exanthem subitum. When they talk, cough, or sneeze, droplets containing the viruses are left hanging in the air. Your child may breathe in the infected air or swallow the droplets and develop the condition.
- Signs and symptoms may include fever, skin rashes, swollen lymph nodes in the neck, and cough. He may also be fussy, confused, feel weak, and lose his appetite. He may have a seizure (convulsion) if his fever gets very high. Your child's caregiver will do a complete medical history and physical examination. Your child may also have blood and urine tests to make sure his fever is not caused by other conditions. The symptoms may go away on its own even without treatment. Your child's caregiver may give anti-virus and fever medicines, and special oral liquids to treat your child's symptoms. Diagnosing and treating exanthem subitum as soon as possible may help your child feel better faster and prevent complications.
- Ibuprofen or acetaminophen: These medicines are given to decrease your child's pain and fever. They can be bought without a doctor's order. Ask how much medicine is safe to give your child, and how often to give it.
- Keep a current list of your child's medicines: Include the amounts, and when, how, and why they are taken. Bring the list and the medicines in their containers to follow-up visits. Carry your child's medicine list with you in case of an emergency. Throw away old medicine lists. Give vitamins, herbs, or food supplements only as directed.
- Give your child's medicine as directed: Call your child's primary healthcare provider if you think the medicine is not working as expected. Tell him if your child is allergic to any medicine. Ask before you change or stop giving your child his medicines.
Ask for more information about where and when to take your child for follow-up visits:
For continuing care, treatments, or home services for your child, ask for information.
Wash your hands and your child's hands often.
This will help prevent the spread of germs. Encourage everyone in your house to wash their hands with soap and water after going to the bathroom. Also wash hands after changing diapers and before preparing or eating food.
Keep your child away from others.
Try to keep your child away from others while he has a fever and feels bad. While your child is sick, he may be contagious (able to spread his sickness). Do not send your child to school or daycare until his fever is gone and he is feeling better.
For more information:
Contact the following for more information:
- American Academy of Pediatrics
141 Northwest Point Boulevard
Elk Grove Village , IL 60007-1098
Phone: 1- 847 - 434-4000
Web Address: http://www.aap.org
- Your child has a fever.
- Your child's skin is itchy or swollen.
- You and your child cannot make it to his next appointment.
- You have questions or concerns about your child's condition, medicine, or care.
- Your child has a fever.
- Your child appears very weak.
- Your child cannot eat or drink.
- Your child becomes blue, has a convulsion, or becomes unconscious.
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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.
Further information
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Reliance Historic Locations
The following historic locations are located in Reliance, Wyoming. Please select a historic place in Reliance to view detailed information including address information, historical signifiance, and much more.
Wyoming Historic Places
|Reliance School and Gymnasium
1321 Main St.
Reliance, WY
Clubhouse, Meeting Hall, Civic, Theater, School, Auditorium, Sport Facility
|Reliance Tipple
E of US 187
Reliance, WY
Wyoming Historic Places


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By sorcha95592 on 17th Jul, 2018
JC Landscaping ServicesNo feedback
Hi there we are a small family run business for over 15 years we specify in all aspects of hard and soft landscaping the team we have are genuine and friendly and willing to listen to our customers and reasonable
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text:
Kirsty Brzeczek here – SPANA's Fundraising and Supporter Care Officer. I recently returned from the Morocco Supporters' Tour and wanted to share with you the tale of one of the happiest dogs I've ever met!
The story starts with newly qualified Vet, Patrick Sells, who not only volunteered with SPANA in Morocco but also raised almost £5,000 by journeying the whole way there on his motorbike! On his way to the Midelt refuge, situated between the Middle and High Atlas Mountains, he spotted a tiny puppy who had been abandoned. Dogs aren't well liked in Morocco as they are thought to carry infectious diseases like rabies so they're often chased away with rocks and stones. Patrick was determined that life would be different for little "Diana" though, who he tucked into his jacket and took with him to the SPANA refuge. He taught the SPANA technicians there how to train her properly and what a wonderful companion she could make. Almost three years later and it's wonderful to see the relationship that's developed between dog and owner and Diana has made an invaluable addition to the busy education programme there.
Tuesday, 2 November 2010
Diana the Dog
Labels: Morocco
1 comment:
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- 18 December 2012 at 15:12
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