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Insubordination can result when difficult employees intentionally disregard a direct order from a manager, or inadvertently cross the discipline line when company policy is involved. Knowing how to handle employee insubordination can go a long way toward avoiding legal consequences when discipline or discharge is necessary.
If termination does become necessary, make sure you have documented employee reviews in case you need to show them in court.
Insubordination defined
Insubordination occurs when an employee refuses a reasonable order from a supervisor or manager. However, a company may be held responsible for a failure in communication that results in insubordination. If the following three elements exist, an employee may be disciplined for insubordination if he or she fails to follow orders:
- The employee understood the instructions
- The order was in line with the employee's duties
- There was no good reason for the empl...(register to read more)
To read the rest of this article you must first register with your email address.


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Always wary of booking accomodation "blind" via websites it was a strong positive signal in exchanging emails with Andrea, one of the owners of Villa di Geggiano. We got the impression we were dealing with a professional of integrity.
So, after 3 weeks on the road from Paris across the north of Italy and back into Tuscany doing the tourist thing, we had booked a week at the "Villa". What a delight to arrive down a tree covered lane to the realtive sanctaury of the Pavillion Suite. This is a very modern conversion/addition to an ancient building with all the aqmenities for the 21st Century. Bathed in sun for most of the day sitting outside looking over the vineyards with a glass of Prosecco was sooo relaxing.
Andrea is a delighful host, available when you need him, but never intrusive. A tour through the 14th century Villa was simply amazing given the original state that it has been kept in. An intriguing hour. A little bonus was Andreas dogs, two Italian sheep dogs one older and a young pup having lots of fun in the magnificent gardens.
Although only about a 12 minute drive to the heart of Siena the location feels vey private and remote. A 4 minute drive down the hill finds two restauarants (the best being Osteria La Piccarda) and a good macellaria and small supermarket.
As a point from which to unwind and relax it is perfect, but also from here we did day trips to Firenze, Siena Montelpiulciano and San Gimignano.
Highly recommended stay as a base or oasis on your next trip.
|How easy was it to book the property?
|How helpful were the directions to the property?
|How easy was key pickup/access to the property?
|Overall condition of the property
|Bedding & mattresses
|Kitchen & utensils
|Bathroom cleanliness
|Other facilities & amenities
|Friends getaway
|Families with young children
My wife & I (very experienced world travelers) recently stayed at this lovely two bedroom guesthouse which is located about 5 miles north of Siena, right in the heart of the Chianti wine region. We have stayed here before and had the same wonderful experience.
This is a modern and tastefully furnished guesthouse that sleeps up to 4 adults in two completely separate bedrooms. It also has a fully equipped kitchen if you choose to cook or buy food and store any provisions during your stay. It has wi-fi and a hot tub which is heated in the cooler months and kept cool during the hot summer months.
The owner, Andrea Boscu, is "sympatico," very helpful and eager to make the stay as comfortable as possible. The villa, which is just steps from this apartment, is an amazing historic property that Andrea's family has owned for over 500 years. Andrea has given us a full tour of the property in the past and it truly is an incredible villa to see.
It is a 10-15 minute drive into Siena, the host treats you like family and the apartment is extremely quiet and peaceful.
We rate this property as one of the best places we have ever stayed in.
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subset: commoncrawl


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Achievers Results Driver for Sales
Achievers' Results Driver for Sales allows managers to create and execute powerful sales incentive campaigns that integrate seamlessly with the Achievers Employee Success Platform. Inspire the performance of your sales team by creating a culture of positive recognition, healthy competition, and real-time results. Visit our website to learn how you can drive better performance and results: www.achievers.com


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A woman who delivers a child vaginally, whether living or stillborn, or who suffers a miscarriage after the 40th day from conception, enters the status of yoledet as well as that of niddah.
A woman who delivers a child vaginally, whether living or stillborn, or who suffers a miscarriage after the 40th day from conception, enters the status of yoledet as well as that of niddah. This applies even if she experienced no bleeding during delivery (an extremely rare situation), but not after a cesarean section. A woman who delivers by cesarean and experiences vaginal blood flow has the status of niddah but is not a yoledet. The laws of a yoledet are very similar to those of a niddah.
The Onset of the Status of Niddah
A woman becomes a niddah when her cervix is dilated during the final stages of labor. She is not halachically required to undergo an internal examination to determine the degree of dilation. From the point that she can no longer walk unaided, we assume that her uterus has opened enough to render her a niddah.
Uterine bleeding during labor also renders a woman a niddah. Rabbinic authorities differ about the halachic significance of the water breaking, and of the release of the mucus plug.
If a woman's cervix is dilated by a few centimeters early in labor (or earlier in her pregnancy), but she has not had any bleeding, she does not yet become a niddah.
A woman enters the additional status of yoledet (a woman who gives birth) with the vaginal birth of baby. The laws that apply to a yoledet are basically identical to those for a niddah. Therefore, since she already became niddah during labor, this has little practical significance. (A yoledet may not immerse until 14 days have passed since the birth of a girl, but postpartum bleeding rarely ends soon enough for this to be possible.)
Cesarean Section
A woman who undergoes a cesarean section is not halachically considered a yoledet (a woman after childbirth). Thus, if she experiences no vaginal bleeding at all, she need not immerse in a mikveh. This, however, is an extraordinarily rare occurrence as a woman almost always has vaginal bleeding as she sheds the remains of the uterine lining from pregnancy. This causes her to become niddah following a cesarean section.
A woman may begin to count seven blood-free days (shivah neki'im) as soon as the bleeding has ceased, after a minimum of five days. Unlike a yoledet, who delivered vaginally, she is not required to wait a minimum of 14 days before immersion following the birth of a girl. However, it is unusual for a woman after birth to cease staining before a few weeks have elapsed, so this rarely has any practical implications.
Husband in the Delivery Room
Childbirth produces wonderful results, but it is often a painful and frightening process. Both medical and halachic sources attest to the importance of emotional support for the mother during labor and delivery. However, the growing trend for the husband to serve as his wife's labor coach presents certain halachic difficulties. First, a woman in childbirth has the status of a niddah. Therefore, physical contact between the couple is prohibited and the husband may not see his wife undressed. Furthermore, the husband is halachically prohibited from looking directly at his wife's vaginal opening even when she is not a niddah. Due to these concerns, many rabbis forbid the attendance of the husband in the delivery room. There are, however, those who permit it with the following stipulations:
1) The couple should request that a mirror NOT be used to allow the husband to see the baby emerging.
2) The couple should request that the wife be kept as covered as possible, or that a screen be placed between her upper and lower body. (This is done routinely for cesarean deliveries and thus should not be difficult to arrange).
3) The husband should not touch his wife unless no one else is available to help her.
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All health and health-related information contained within Nishmat's Women's Health & Halacha Web site is intended to be general in nature and should not be used as a substitute for consulting with your health care professional. The advice is intended to offer a basis for individuals to discuss their medical condition with their health care provider but not individual advice. Although every effort is made to ensure that the material within Nishmat's Women's Health & Halacha Web site is accurate and timely, it is provided for the convenience of the Web site user but should not be considered official. Advice for actual medical practice should be obtained from a licensed health care professional.


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From the publisher
Wartime magazine is the military history magazine of The Australian War Memorial. Published quarterly, the 76-page magazine is devoted to the Australian experience of war; military history; and the effects of war on society. All features are written by eminent historians and deal fully and frankly with both the distressing and the lighter sides of war.
Each issue delivers many stories of courage and survival of both service personnel and civilians and is a must-have for any history buff.
Be the first person to tell us what you think about Wartime and you'll save $5 on your next purchase!ADD A REVIEW
Weeks delivery
For quarterly titles please allow up to 10-13 weeks for your first delivery. Your subscription will begin with the next available issue.


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Hello all of you fellow mothers of tweens. If your tweens are anything like mine, they might be struggling to come up with something suitable to share with their classmates on Valentine's Day. Don't get me wrong, there are some amazing Valentines out there, both store bought and DIY. However, when you get to be middle school age, there is a fine line between little kid cheesy and over-the-top cool.
It's important for this age group to celebrate LOVE day (although few will admit it), after all, these kids are no longer worried about "cooties", but most pre-teens I know don't want to appear to have spent much time on their classmates' favors.
Thank goodness, Paper & Strings came up with this brilliant idea for embellished breath mint favors. They are understated with just a hint of decoration, but definitely useful for every pre-teen. You can print out your own free printables from their website.
We purchased our breath mints in multi-packs from The Dollar Tree and printed our printables on 8 pt. glossy cardstock at Office Depot.


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So this morning I set my alarm for very early, "gonna have an early productive day to kick off a productive week!" was my intention, but I snoozed twice and the third alarm was still pretty annoyingly early, so I grabbed my phone to see if I had any cool emails that would help me out of bed. YES I DID. I flew out of bed faster than I do when I think spiders are crawling on me and raced down to find the illustration below! An artist named Corey Lee, who has both a blog and a website for his work, sent me this email:
Hi, I'm Corey, an illustrator, and I came across your blog not too long ago. I like to occasionally do drawings based on fashion, so with all your pictures of different outfits, naturally I had to draw one of them. I did a drawing based on you Mrs Fox post(http://secondskinstyle.
SO Freaking COOL right!!?? WOW! I my socks literally blew off my feet (well figuratively since I wasn't actually wearing socks to begin with.) I went over to the site to find that Alyson had very sweetly told him my name was Christina (but my middle name is Marie). I noticed that along the side of my purse he had written "We won't let you in," So, I wrote him an email thanking him of course and requesting permission to post his work here. I also asked about the text. Apparently he scribbles in a little line from the song he is listening to while he is drawing. The song he is referring to in this sketch is this one by the band Brand New. He has some really great work and I completely recommend a leisurely stroll through his sites! He is one to know about.
I love drawing, art, and fashion, and this illustration marries them all together seamlessly (pun slightly intended). There are so many examples of fashion-based drawings out there, and this one really tops the cake. :)
Toast with Charmalade


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Nicole Lalonde commented 2016-09-22 16:08:46 -0400
two faced , lame and fake and……………………………………. trustworthy ????
It was strange enough to see self-proclaimed feminist Justin Trudeau attend a gender-segregated mosque and justify it on the basis of "diversity" and now pressed again by Bloc Quebecois MP's, the Liberals have taken it to absurdity.
Watch as Liberal Minister for the Status of Women, Patricia Hajdu, tries to justify their willingness to ignore the blatant unequal treatment of women Trudeau witnessed in that mosque.
It's bizarre to say the least for the Liberals to say "because abortion", therefore we can ignore brazen lack of regard for the fundamental Canadian value of equality between men and women.


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Pacific Union College
Pacific Union College, located in California's Napa Valley, is a four-year liberal arts college accredited by the Western Association of Schools and Colleges. Founded in 1882 by the Seventh-day Adventist Church, PUC offers a Christ-centered undergraduate education that prepares its students for productive lives of useful human service and uncompromising personal integrity. The college's overall program, with a full lineup of bachelor's degrees, is frequently ranked among the region's top baccalaureate colleges.
This event specifically supports the Student Association and Service-Learning programs at PUC in their efforts to connect the mission-minded student body with opportunities to make a difference in neighboring communities. Past beneficiaries of student efforts include the Napa Valley Food Bank, Napa Valley Land Trust, and Rebuilding Calistoga.


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St. Louis scores in OT for LightningNHL.com @NHLdotcom
WINNIPEG, Manitoba (AP) -Martin St. Louis scored his second goal of the game on a power play with 7 seconds left in overtime to give the Tampa Bay Lightning a 4-3 exhibition victory over the Edmonton Oilers on Thursday night.
"He's just smart, he's just dangerous on the ice," Lightning coach Rick Tocchet. "He's the ultimate pro."
Ryan Malone and defenseman Kurtis Foster also scored for Tampa Bay (3-1-2) in front of a crowd of 11,644 at MTS Centre. Foster tied it with 1:37 left in regulation, firing a long shot that went through traffic and past goalie Jeff Deslauriers.
Robert Nilsson, Andrew Cogliano and Tom Gilbert scored for Edmonton. The Oilers have lost four straight to drop to 3-4-0.
"We still are a team that overpasses," Oilers coach Pat Quinn said. "Some of our guys want to pass it into the net, you know. But that's just a recognition of what you have and what kind of things you can make happen."


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Now more than ever, creative people with new ideas and new approaches to problem-solving are in high demand. New Jersey City University's Art Department nurtures and develops artists through a balance of history and tradition alongside contemporary aesthetic ideas, skills, techniques and technologies.
Your creativity and leadership skills will flourish under the individualized attention of our experienced faculty who will prepare you to thrive in today's competitive and dynamic art world. Proximity to New York City places you minutes away from museums, galleries, design studios, agents, curators, critics and art collectors. NJCU faculty leverages this proximity to help you unlock your full potential and gain practical insights into launching a successful art career. Our complement of studio and non-studio concentrations offer an array of opportunities to learn, grow and follow your passion.
Students create and study in the Visual Arts Building, a state-of-the-art learning environment that fosters creativity and collaboration. With three galleries and an outdoor sculpture space, exhibition space is ample. You will find work by acclaimed and emerging artists, as well as students and faculty. Exhibitions are often accompanied by panel discussions and programming that maximizes the learning experience.
The New Jersey City University Art Department is accredited by the National Association of Schools of Art and Design. NJCU's Art Department graduates become artists, designers, teachers, scholars and leaders. What will your future hold?
See our faculty profiles
Winifred McNeill, Interim Chairperson
Visual Arts Building, Room 120
(201) 200-3214


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Member Favorites: 6
Masumi Koutsu (光津 真澄)Masumi is the representative for the Leo Institute of Dueling Fusion Summon course. She uses a "Gem-Knight" Deck. Masumi is a direct, straightforward and bold individual, showing little to no hesitation in saying what she believes. Due to her father's job and witnessing and appraising the value of jewels, she is seemingly capable of detecting talent and hesitation within people, as she did with Yuzu at the start of their Duel. Although Masumi shows a penchant for mockery, most of what she states is accurate thus, she does not act out of plain arrogance but on observation. Masumi is also a caring person, valuing her friends and her teachers, and after Professor Marco's disappearance, she became frantic in her attempts to find him. She cares for (and possibly has a crush) on Marco particularly, and doesn't tolerate insults towards him.
Voice Actors


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US aviation regulator to audit flight ops in India
US aviation safety regulator wants to conduct an independent audit of flight operations in India this August because of safety concernsmumbai Updated: Jun 22, 2013 03:00 IST
Concerned about air safety regulation in India, the US aviation safety regulator wants to conduct an independent audit of flight operations in India this August. Last week, the Federal Aviation Administration (FAA) told its Indian counterpart to prepare for the audit.
According to sources in the civil aviation ministry, the FAA's concern stems from the United Nation's aviation watchdog's recent report on air safety regulations in India.
Civil aviation minister Ajit Singh confirmed the forthcoming FAA audit. "We have received a letter about it, but I do not have the details," he said.
In March, the International Civil Aviation Organisation (ICAO) had named India among 13 countries with the most dismal air safety monitoring records.
According to the report, the DGCA's safety monitoring standards have been below the global average across all parameters such as legislation, licensing, organisations, etc.
Air safety experts said that this audit was important because the FAA could downgrade India if its officials were not satisfied with the safety standards. "It could mean that the US government could introduce restrictions on Indian airlines operating in the US," said an air safety expert.
This is the second time that India is facing fears of being downgraded. In 2009, the FAA had threatened to revise India's position to category II, citing massive staff shortage in the DGCA.
First Published: Jun 22, 2013 02:55 IST


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Wishing you the happiest of holiday seasons!
I happen to love Bill Moyers, and during the year, I don't get the chance to watch his program on PBS as often as I would like.
as luck would have it,
enjoying a conversation at a friends house the other day,
they played me a recent Moyers show
featuring Mark Johnson and his documenatary --
"Playing for Change. Peace through Music."
(I found the segment very moving. -- it runs about 20 minutes.)
thought I would share as my Christmas communication....
in case you felt like catching an inspiring wave of connectedness as we ride out 2008 and head into the new year...
theologian James Dunn spoke of --
the humility that befits all humanity
the hurt that afflicts every heart
and the hope that comes with community
an old theme in American history.
there is strength in the company of others
from "we the people" to "we shall overcome."
to quote Bill Moyers --
"there is much to repair. if we have the will for it."
thanks for being a part of my community.... and. I look forward to more strength in action in the coming year!
"playing for change. peace through music."
(This first aired before the presidential election on Bill Moyers The Journal on PBS....)
(interview with Mark Johnson, the producer of a remarkable documentary about the simple but transformative power of music. )
if you want to donate to PBS:
if you want more info on Playing for Change:


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Welcome to Dancing Moose Montessori
The name "Dancing Moose" focuses on a creative philosophy that combines the arts with academic excellence. Low student-to-teacher ratios ensure that Dancing Moose students are learning at their own accelerated pace.
Providing quality curriculum for children aged 18 months through third grade, Dancing Moose attracts highly educated teachers who choose to build their career in the rewarding field of early childhood education.


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The Foray drafts off the bold design language of our premium Synthe helmet, and offers many of our key features including durable In-Mold Construction and the Roc Loc5 fit system with two-way fit adjustment. The slim design is very light, offers great ventilation and is available in three Super Fit sizes so that you can get a helmet that looks, fits and feels like it was made for you.
Based on the design of the premium Synthe helmet
In-mold construction combines polycarbonate outer shell with impact-absorbing foam liner
Roc Loc 5 offers a comfortable fit that cradles your head
Compact, stylish shape
Three size Super Fit system is based on 20 years of data on human head shapes
$54.99 $80.00
Engineered with for day and night use, the Streak™ 450 headlight and Hotshot SL™ 50 tail light combo set delivers exceptional lighting coverage. The pair fires up an impressive 450 lumens forward and 50 lumens backwards to have you visually covered at night. Not only limited to night, both pack DayLightning® mode to make you stand out in broad daylight with powerful lightning-like flashes, giving you the advantage any time and anywhere you ride. Get the most out of your ride with the performance and features packed into this combo light set.
LED OUTPUT 450 lumens
CHARGE TIME 3 hrs
MOUNTING Handlebar
BATTERY Built-in Li-ion
SYSTEM WEIGHT 90 g
Hotshot SL™ 50 USB
LED 50 lumens flashing
CHARGE TIME 3 hrs
MOUNTING Seat post
BATTERY Built-in Li-ion
SYSTEM WEIGHT 55 g
This product includes:
Streak™ 450 headlight, Hotshot SL™ 50 tail light, Locktite™ tool-free handlebar mount, seat post mount, mini USB charging cable
Featuring a simple, strong and aggressive design, the Ultra 410 with Cobra Cable (and Ultra 410 Mini) is the ideal entry level u-lock and rounds out the Super Ultimate and Ultimate line-up. Its simple design conceals a number of high-tech advancements in security such as the double bolting U-Lock and double layer wafer cylinder, which when combined with the cobra cable, adds security, versatility and makes this 'Sold Secure' approved lock an even greater value.
12mm round shackle with cobra cable
Innovative soft touch housing cover prevents damage to paint
Shackle, body, and supporting elements made from temper hardened steel for cut and torsion resistance
Pass-through shackle provides anti-twist protection
SH 34 bracket mounts easily to frames with a 24-35mm diameter
Toughest tire levers backed by Pedro's lifetime warranty! Don't ride without a pair!
Award winning, universally loved, and available in bright yellow, pink, green, and orange colors
Molded box construction and proprietary plastic blend makes these the strongest levers available
Chisel tip shape is easy to insert beneath the bead and the slightly thicker shape keeps the tire lever from slipping
Bold shape makes it easy to remove the tightest of tires without bending or breaking
Stay stoked!
Sign up for latest rides and deals!


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PLATTSBURGH - The screens are up, the seats are in position and the doors are now open at Cumberland 12 Cinemas.
The new 12-screen theater megaplex on State Route 9 held a private grand opening Dec. 18, which included guests such as town and county officials, members of the media and other local businesses.
Peter W. Edelmann, president of EuroWest Companies, Essex, Vt., the firm which owns the megaplex, said the soft opening was a perfect opportunity to test the waters for the new facility, which opened its doors to the general public the following day.
"The general reaction and the one that I enjoyed hearing was it is hard to believe this finally is happening in Plattsburgh," said Edelmann. "We also received many 'thank-yous' for providing extra wide and comfortable seats. Young and old alike, gave very positive comments."
The official opening weekend was slower than expected, though Edelmann attributed that to the inclement weather that hit the area. He added the business has been selling strong advance sales and gift certificates, however.
Plattsburgh Town Supervisor Bernard C. Bassett, who was in attendance for the advanced opening, said he was impressed with the overall facility and its ability to attract more people to the town.
"It does bring more money into the economy and it's another reason for our friends in Vermont and Canada to come to this area to be entertained," said Bassett.
The development has also meant new full- and part-time jobs for approximately 70 people, said Bassett, which is imperative at a time when other businesses are cutting back their workforces. It's Bassett's hope other employers will follow EuroWest's lead to expand businesses and services within the town.
"As the saying goes, "A rising tide raises all ships.' People will see something good happening and they'll want to be a part of it," said Bassett. "It's just another good example that we're alive in the town of Plattsburgh."
Edelmann said he cannot thank town officials and staff enough for "providing an atmosphere that allowed for continued permitting and opening progress." He further thanked Conroy and Conroy Contractors, who were hired to perform the work at the site.
Cumberland 12 is merely the beginning of the renovation of the former North Country Shopping Center plaza, said Edelmann. The existing shopping center building will eventually be demolished, with 600,000-square-feet of commercial buildings expected to take its place.
"We still have a lot of work to do for further development and look forward to working on our small role in helping create jobs and bring a new diversity of entertainment, dining and retail options to Plattsburgh," said Edelmann.
For more information about Cumberland Cinemas, visit their Web site at www.cumberland12.com or call their movie line at 324-3777.


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I got a beautiful napa cabbage at the farmer's market this morning and I am looking for something to do with it that's different than the usual.
Crunchy Asian salad with sesame-lime dressing, kimchi, add to soups, stir fry with onions and curry powder or curry paste, dumplings, spring rolls....
Make kimchi! Homemade kimchi is the BEST!
Homemade kimchi is great (I make it myself), but that suggestion is neither original nor unusual.
It would have been more helpful had MartiC mentioned what he/she normally made with Napa cabbage, so people here wouldn't suggest previously executed dishes. Alas, that information was not provided.
It might not be unusual to you, but maybe it is to MartiC? Anyhow, let's try to be helpful and kind here and keep the snark to a minimum?
Cut into bite sized pieces. Saute with an onion, some ham, some chopped sundried tomatoes (or whatever tasty bits you have in the fridge). Serve over spaghetti with lots of parm cheese.
okonomiyaki is my very fav use of napa. Look at Just One Cookbook's blog for exc. recipe. Pretty simple Japanese pancake...
midge's Okonomiyaki was an early and popular contest winner at food52 https://food52.com/recipes...
This cabbage veloute is really nice, and quite different http://www.foodandwine...
cabbage and bowtie noodles (a traditional Jewish recipe)
Rakott Kaposzta (Hungarian layered cabbage)
I'm not sure what "the usual" is for you, but this is a great recipe: https://food52.com/recipes...
This Vietnamese Crab "Coleslaw" is very good (I've subbed shrimp): http://cooking.nytimes... Shredded Napa cabbage is also good in Asian noodle salads.
My mother use to make a simple soup by simmering a cut of top round (sometimes called "london broil") until tender, then simmering the napa cabbage (halved), until it was tender as well. The broth was seasoned with only salt and black pepper. Cut up the beef and returned to the broth, but leave the napa intact. You picked off the leaves as you ate (family-style). Serve with rice and a main 'entree'. Nothing too exotic, but comforting and filling on a wintry evening.
This recipe is delicious and goes well with all sorts of meals: https://food52.com/recipes...
I use napa although not specified and it is a beautiful slaw.
Go to Pinterest and under Search type in
Asian Stuffed Napa Cabbage Rolls. They are easy to make and taste great!!!


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It was time to put a stop to it. I knew the road I was on only had one ending, and it was a bad one.
And now...WOW!! What an incredibly different path my life is on! I am healthy, happy, exercising, in love. The future is so bright, baby!
I'll probably wax nostalgic over the next several posts as I really reflect on this achievement, but for today, I just want to revel. Here's a couple pictures to celebrate!
|Goal, baby!
|Home on medical leave after WLS
Goodbye to the


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Welcome to this edition of EnergyAg Newsbriefs brought to you by the Washington State University Extension Energy Program Library. Please forward this issue to those of your colleagues interested in energy-efficient agricultural practices. Archives of past messages
While every URL in EnergyAg Newsbriefs is checked for accuracy prior to distribution, URLs may change, and servers may temporarily fail to connect to working URLs.
New plant will digest King County dairy manure
A manure biodigestion plant under construction in Enumclaw, Washington, will collectively process manure from a consortium of King County dairy farmers. Electricity from the plant will be sold to Puget Sound Energy. For information, see "Cow Manure to Power New King County Plant," appearing December 12, 2011, at MyNorthwest.com.
Hog farm digester "cleanest in existence"
"A Farm Lives High – And Clean – Off the Hog," published December 25, 2011, in the Los Angeles Times, describes a North Carolina hog farm's anaerobic digestion system. The system, developed by Duke University and partially funded by Google, was described by its creators as the "cleanest in existence," and could serve as a prototype for other farms due to the simplicity of its design.
Biodiesel inputs vs. outputs
"Energy Life Cycle Analysis of Biodiesel," updated December 19, 2011, on the eXtension website, describes the process of energy life cycle analysis, whereby the inputs and outputs of a biofuel production system are weighed, and explains why results from different studies can vary so widely. Results from recent studies on soy biodiesel are presented, and the importance of these and similar studies is assessed.
Oilseed production case studies
A study published by Washington State University in July 2011, "Oilseed Production Case Studies in the Eastern Washington High Rainfall Zone," provides readers with detailed information about the trials, successes, and challenges of oilseed crop growers in Eastern Washington. A summary of the study, Studies Published of Oilseed Growing in Eastern Washington, appeared December 7, 2011, in WSU News.
Oregon plant to convert farm, food processing waste to energy
A new biorefinery in Boardman, Oregon, will process onion, potato, and other agricultural waste from local farms and processors. According to Novus Energy CEO Joe Burke, the plant will produce methane gas in four or five days, and convert 90 percent of the feedstock to methane gas, liquid fertilizer, water, and a dry soil supplement. For information, see "Tim Hopkins Energy Start-up Ready for Major Launch," published December 4, 2011, in the Star Tribune.
Macadamia nut biochar found to reduce CO2 emissions
Results of research from the USDA Soil and Water Management Research Unit found that soils amended with biochar showed a reduction in greenhouse gas emissions, particularly when the biochar comprised 20 percent or more of the soil volume. Additionally, the study revealed a relationship between soil microbes, biochar, and ethylene production. The research is summarized in "Findings on Biochar, Greenhouse Gas Emissions and Ethylene," posted December 13, 2011, on the USDA website.
Dairies cut costs while saving energy
An article published November 10, 2011, in Capital Press, "Technology Upgrades Cut Costs," describes the efforts of Idaho dairies to cut costs and save energy. By making simple energy efficiency upgrades, such as switching to higher-efficiency light bulbs and upgrading to variable speed drive vacuum pumps, the featured dairies were able to significantly reduce energy expenditures.
Final 2011 REAP funds announced
On December 15, 2011, the United States Department of Agriculture (USDA) announced the final round of REAP funding for FY 2011. Funds will be provided for agricultural producers and rural small business in 8 states to cover up to 25% of renewable energy and energy efficiency projects. To learn more and see the list of recipients, read the USDA press release.
Report enumerates value of Oregon's agricultural lands
The Oregon Department of Agriculture (ODA) released a new report in December 2011 titled "A Comprehensive Valuation of Agricultural Lands: A Perpetual Investment in Oregon's Economy and Environment." The report examines the value of agricultural lands in the state, and finds that the economic and environmental benefit derived from its conservation are greater than what can be achieved from development. In the words of Jim Johnson, Land Use Specialist, ODA, "You can only produce one crop of houses, but if that land remains in agriculture, you can produce a crop year after year after year."
Energy-smart food model can feed the world, says UN report
An issue paper published November 29, 2011, by the Food and Agriculture Organization of the United Nations, "Energy Smart Food for People and Climate," prescribes an "energy-smart" model of food production for agriculture worldwide. The paper, which was published at the UN Climate Change Conference in Durban, details energy-saving measures for every stage of agricultural production and distribution, including the use of more efficient engines, compost and precision fertilizing, targeted irrigation, no-till farming, and improvements in food transport and storage.
Drivers and solutions for global food price hikes
The Food Crises: A Quantitative Model of Food Prices Including Speculators and Ethanol Conversion is a 56-page report by M. Lagi, Yavni Bar-Yam, K.Z. Bertrand, and Yaneer Bar-Yam, all at the New England Complex Systems Institute (NECSI); it was published September 21, 2011, at arXiv (arXiv:1109.4859v1). The researchers determined the major causes of worldwide increases in food prices and how to track them for policy-making purposes. They conclude that investor speculation and ethanol conversion are the causes, and they show that supply and demand do not coincide with price changes as is often maintained. The authors explain that the model they developed accurately shows what is causing higher prices. Rational policy decisions, needed to reduce growing hunger, can be made.
FarmWare 3.6 released
The U.S. Environmental Protection Agency (EPA) AgStar Partnership Program released FarmWare 3.6, an updated version of its FarmWare software, on November 17, 2011. FarmWare is a modeling software which, given the appropriate inputs, can estimate the costs and returns of integrating an anaerobic digestion system into an existing or planned livestock facility.
Tips for calculating payback from energy-saving investments
"Estimating Payback for Energy Efficiency," published in November 2011 by Iowa State University Extension, provides tools for evaluating the investment vs. return of energy-saving equipment purchases. Calculations are given for determining the break-even point of energy savings vs. outlay, thus providing valuable decision making criteria for those looking to replace older equipment.
2012 No-Tillage ConferenceJanuary 11-14, 2012, St. Louis, MissouriOnce again, we've lined up nearly 40 of the very best no-tillers, crop consultants, agronomists and researchers to deliver cutting edge ideas, tips, and techniques to raise your no-till profitability, efficiency, and effectiveness to a higher level. Our theme, "Two Decades of No-Till Know-How," reflects the effort, dedication and perseverance of growers, consultants and researchers throughout the world seeking to make no-till an integral business strategy and lifestyle among farmers. This 20th annual National No-Tillage Conference offers 7 general sessions (with 16 powerful presentations), 20 No-Till Classrooms and 60 invaluable No-Till Roundtables. Plus, nearly 30 hours of valuable pesticide recertification and Certified Crop Advisor credits are available.
Pacific West Biomass Conference and Trade ShowJanuary 16-18, 2012, San Francisco, CaliforniaWith an exclusive focus on biomass utilization in California, Oregon, Washington, Idaho and Nevada, the Pacific West Biomass Conference & Trade Show is the largest event of its kind in the world. The mainland Pacific West—from Southern California to British Columbia—is home to dozens of biomass power plants, advanced biofuels startups, research hubs and vital industry associations. This event brings together area producers of biomass-derived electricity, industrial heat and power with waste generators, municipal leaders, utility executives, technology providers, equipment manufacturers, investors, policy makers and more.
Pasture-Based Dairy Online CourseOnline, January 17 - March 23, 2012The University of Missouri (MU) is offering a 9-week team-taught (14 instructors) course covering the topic of pasture-based dairy farming. The course was offered to MU undergraduates in Spring 2011 for the first time and received very positive reviews. Beginning in Spring 2012, the course will still be offered to traditional MU students, but will also be opened up to off-campus and non-traditional students such as current dairy farmers that are considering transitioning from confinement to management intensive grazing, or to those that are considering starting a pasture-based operation.
TEDx Manhattan: Changing the Way We EatJanuary 21, 2012, New York, New York and webcast live This one-day TEDx event will explore the food system — from what happened, to where we are, to what we are doing to shift to a more sustainable way of eating and farming. The goal of "Changing the Way We Eat" is to create new synergies, connections and collaborations across disciplines, to unite different areas of the food movement and to introduce the TEDx audience to the exciting and innovative work being done in this field. The Glynwood Institute for Sustainable Food and Farming is the lead sponsor for TEDxManhattan. The event will be webcast live, and individuals, groups, and organizations are encouraged to host viewing parties.
Oilseed Crop Production WorkshopsJanuary 24, 2012 - Odessa - Odessa Community CenterJanuary 26, 2012 - Colfax - Hill Ray PlazaMike Stamm, canola breeder in the Agronomy Department at Kansas State University, is the keynote speaker at both workshops. Stamm will share the challenges and opportunities he has observed with canola production in the Great Plains, as well as results from the national canola variety testing program. Other confirmed speakers include Heath Sanders, oilseed agronomist with Producers Cooperative Oil Mill in Oklahoma City; Jeff Scott, an experienced canola grower from Pond Creek, OK; Tom Gehring, senior agronomist with Primeland Cooperatives in Cottonwood, ID, Brian Lorentz of Columbia Grain International in Grangeville, ID; and George Weicker, Feed Mill Operations Manager with National Food Corp. in Arlington, WA.
32nd Annual EcoFarm ConferenceFebruary 1-4, 2012, Pacific Grove, CaliforniaAs the oldest and largest ecological agricultural gathering in the West, the EcoFarm Conference meets every year to create, maintain, and promote healthy, safe, and just food farming systems. With over 1,500 attendees, the three days yield myriad opportunities for networking with colleagues, discovering the newest ecological agricultural development and techniques, and building skills for us as individuals and together as a community.
Want to Contribute? If you have information on events, publications, or other ag-related topics that you would like mentioned in an upcoming issue of EnergyAg Newsbriefs, please contact Talia Mathews at email@example.com.


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Separate names with a comma.
Discussion in 'Mac OS X 10.3 (Panther) Discussion' started by TheWitePony, Oct 23, 2003.
Just got it a few minutes ago via FedEx. Installing now....
How long did panther take for you to install? 7b85 took me about 20 minutes on my dual 867MHz MDD with a gig of ram
also, what revision is the retail version?
on my 1Ghz TiBook, 512MB RAM doing an archive and install, no additional language packs, it took less than 45 minutes.
the only 2 little tiny glitches was i needed to upgrade Toast to 5.2 (i had 5.1) and i needed to specifiy which version of Stuffit to unstuff files (for whatever reason i had 2 versions on the machine)
so far its just freakin great. fontbook rocks. expose is SO fast and beautiful its just a marvel to see it happen. i really like teh slightly subdued look + feel. so far it defintely feels much snappyer, i am hesitant to say its "faster" yet - lemme use it for a week.
congratulation! could i ask you to make me a favour?
could you pleas put in your panther installation cd 1 an select 'Install Mac OS X'. then go to the menu 'File' and then 'Information'. could you then tell me the exact date that stands in the section 'Last modified:' of the window that just opened?


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A Pesky Propaganda
Protector of "Peace" and "Justice"
Pavel Shemov
Perception 12
Insight 12
Knowledge Skills: None
Languages: Common, Elven
There's nothing I enjoy more than long walks on the beach. Some of my other hobbies include watching the sunset from a picturesque grassy knoll, indulging in fine wine with a scrumptious foie gras dinner, and candlelight conversations on our great lord Asmodeus.
As a young lad Peval had a somewhat questionable relation with the law. Breaking and entering, followed breaking and taking was his style. Considering that his only role model being a father that would routinely finish his first bottle before noon, it was only natural to take up this sort of lifestyle if he were to get by. Being fairly large for his age certainly made things easier, but it would also cost him greatly in the end.
On one particular outing, overestimating his "stealthiness" and speed, Peval was caught by the local police and subsequently charged for his crimes. His options weren't many: pay a large fine, removal of unnecessary limbs for failing to pay said fine, or working off the fine by joining the military. Not entirely overjoyed…but then not entirely unhappy…Peval joined the military to pay off his debts to the government, and so his adventures began.
Peval's early days showed his inexperience in actual fighting, but he learned quickly. Soon, he found it strangely enjoyable to go into battle: he looted what he could in secret, skipping camp for the nearest tavern whenever the opportunity arose. His only regret being the standard issue weapons and armor…why did it have to be a sword? Swords are "too good" at what they do: one swing and your opponent is dead, Peval wanted to savor the experience. It's thoughts like these that first made him think that maybe he should join the police if…when…he got out of this.
The last day of his stay at the army came as a surprise…for him and his troop at least. They were off to take down a group of unlicensed bandits. They outnumbered the bandits ten to one, were better equipped, and undoubtedly had more experience as fighters than a group like that ever would. Coming up on the group, it was obvious that some of the info was a bit off: sure, it was a small group…but around half of their members had armor that looked to be of the highest quality, polished to the point that it could reflect the sunlight into your eyes as if it were a mirror…and, coming closer now, emblazoned with the sigil of Asmodeus. These were clearly paladins of Asmodeus. Peval had heard of them before, but surely they were no match for his troop, outnumbered as they were. His commanders were surprisingly unsurprised by the matter, although clearly more uneasy than he'd ever seen them. Why? The orders were given to charge in.
Several hours later, Peval awoke to silence, he had been knocked out with a hard blow to the head by one of their shields. Everyone was dead, or at least everyone that he could see. As he walked around the corpses Peval heard a sound, the raspy breathing of a dying man. It was a paladin, with his sword driven into the chest of the troop's leader, clutching a similar wound of his own. "Hah! It seems that Asmodeus has smiled upon you, boy!" Peval paid him no mind, grabbing a nearby sword to finish the job, then thrusting at his enemy's throat. In a flash he was disarmed, with a sword upon his throat in turn. "I meant what I said. I'll be dead within the hour, but don't think that the likes of you can put a scratch on me. Go east until you reach the border, then seek the audience of someone that can train you in our ways. You have what it takes, I'm sure of it." Peval, amazed at the man's tenacity, came upon a sudden realization: everyone he knows is dead. Who is to say that he didn't die on this battlefield as well? Maybe this was his calling, since he himself certainly had no future here… Looking into the dying man's eyes, he nodded and slowly backed away, turning to walk away into the east. As he neared the edge of the battlefield he rummaged throughout the belongings of one of the fallen soldiers. He took his money, sword, and most importantly his papers. "Pavel", huh…what a coincidence.


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Regardless of your organization's unique aspirations and challenges, we will work closely with you to develop and deliver the people solutions you need to foster STRONG LEADERS, STRONG TALENT and STRONG CULTURES.
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A Randomised, Multicentric, Phase 2a Study Evaluating the Impact of an Immunotherapy by IL-7 on CD4 Lymphopenia, Risks of Severe Haematological Toxicity and Tumor Progression in Metastatic Breast Cancer Patients
A key secondary objective is to determine if CYT107 treatment enables to reduce the
incidence of severe haematological toxicity (any type of haematological toxicity Grade ≥ 3)
Other secondary objectives are to assess the impact of CYT107 treatment on the following
- Overall incidence of side effects (any type any grade)
- Progression-free survival (PFS)
- Compliance to chemotherapy regimen (dose intensity, number of chemotherapy cycles).
- CD4 lymphopenia over the study period
Exploratory biological markers
A series of biomarkers analyses will be performed to evaluate if CYT107 treatment will:
- selectively stimulate the proliferation and activation of peripheral immune subsets
(analysis of phenotype and activation status of peripheral immune e sub-populations)
- selectively improve the functional response of T cells, DC subsets and NK cells.
- is able to revert tolerogenic immune burden to increase specific anti-tumor response
(measure of antigen specific CD8 response, measure of cytokine plasmatic levels)
- enable to increase TCR diversity (analysis of combinatorial diversity).
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
to determine the optimal schedule to deliver CYT107 during chemotherapy based on restoration of CD4 count
Evolution of CD4 count from Day 0 to Week 11 with repeated measures from D0 to W12 (D0, D21, D57, D78).
after 11 weeks of treatment
Isabelle Ray Coquart
Principal Investigator
Centre Léon Bérard, Lyon
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
June 2011
June 2014


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Kaley Cuoco & Ryan Sweeting Step Out After Engagement News!
Kaley Cuoco picks up two beverages from her local Starbucks on Saturday morning (September 28) in Sherman Oaks, Calif.
The 27-year-old Big Bang Theory actress showed off her new engagement ring two days after it was revealed she is engaged to her boyfriend of three months, tennis player Ryan Sweeting.
Ryan was seen stepping out for a chat on his cell phone the day before in Sherman Oaks.
If you are not familiar with Ryan, make sure to check out our quick get to know feature on him!
25+ pictures inside of Kaley Cuoco and Ryan Sweeting out and about separately after getting engaged…


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My current research interests fall into two main areas:
Previously I was interested in using machine learning to predict T-cell epitopes and I also studied zero-divisor graphs of matrices.
Mathematical models of cancer evolution
In healthy tissues, cell division and cell death are tightly controlled processes, which enable a precise balance assuring that the number of cells in the body remains approximately constant. However, during each cell division mistakes in DNA replication can occur, leading to accumulation of mutations in individual cells. The majority of such mutations are effectively neutral (passengers), but some of them (drivers) can provide selective advantage to the cell, by tipping the balance of cell division and death in favor of increased proliferation. This unwanted evolution of somatic cells can lead to a clonal expansion of cells with driver mutations, which can ultimately result in the formation of tumors and seeding of new lesions in distant tissues. I am interested in studying how mutations accumulate both in healthy tissue and in cancer. My approach combines developing and studying mathematical models of genetic evolution together with genomic data to obtain insights into these important, but hidden evolutionary processes.
1. Stochastic evolution of driver and passenger mutations
We developed a stochastic model for accumulation of driver and passenger mutations during cancer evolution and studied the relationship between the number of drivers and passengers in individual cancers. After a cell with the first driver initiates clonal expansion, at every cell division its progeny can collect new driver mutations with some small probability, forming a new cell type. Each subsequent driver provides additional selective advantage to cells, leading to an even faster clonal expansion. In this multi-type branching process model, cells can also collect passenger mutations, which have no effect on fitness. We fit our theory to sequencing data from glioblastoma and pancreatic cancer and show that the selective advantage of driver mutations in human cancers in vivo is surprisingly small, and amounts to less than 1% reduction in the death rate. Studying the effect of a single additional driver on tumor evolution using a two-type branching process, we observe that early, small lesions need additional drivers, while late stage metastases are only marginally affected by them.
I Bozic et al. (2010) Accumulation of driver and passenger mutations during tumor progression. PNAS 107, 18545-18550.
JG Reiter*, I Bozic* et al. (2013) The effect of one additional driver mutation on tumor progression. Evolutionary Applications 6, 34-45.
2. Passenger mutations as a molecular clock in healthy stem cells and in cancer
Using a novel methodology that utilizes cancer sequencing data, we are able to estimate the rate of accumulation of mutations in healthy stem cells of the colon, blood and head and neck tissues and refute the immortal strand hypothesis. This hypothesis has been proposed as a mechanism used by stem cells in order to minimize the accumulation of mutations in their genomes. The number of mutations in cancer tissues correlates significantly with the age of the patient, independent of the cancer stage. Difference in the numbers of somatic mutations detected in the cancers of patients of different ages can be explained by the difference in the length of the self-renewal phase in the lineage that lead to cancer, which allows us to infer the normal rate at which mutations accumulate in healthy stem cells.
We also use passenger mutations as a molecular clock to study the length of pancreatic cancer evolution. Most pancreatic cancer patients are diagnosed with metastatic disease and have median survival of less than a year. Whether the dismal prognosis of patients with pancreatic cancer compared to patients with other types of cancer is a result of late diagnosis or early dissemination of disease to distant organs is not known. Relying on data generated by sequencing the genomes of multiple metastases and primary tumors from seven pancreatic cancer patients, we performed a phylogenetic analysis to evaluate the clonal relationships among primary and metastatic cancers in individual patients. Using the fact that passenger mutations are collected with some probability at each cell division, we then performed a quantitative analysis of the timing of the genetic evolution of pancreatic cancer. Our results indicate at least a decade between the occurrence of the tumor initiating mutation and the acquisition of metastatic ability and define a broad time window of opportunity for early detection to prevent deaths from metastatic disease.
C Tomasetti and I Bozic (2015) The (not so) immortal strand hypothesis. Stem Cell Research 14, 238-241.
S Yachida, S Jones, I Bozic et al. (2010) Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114-1117.
3. Spatial model of cancer evolution
We study the genetic evolution of cancer in three dimensional space. We are interested in how drivers and passengers accumulate in the presence of spatial constraints due to crowding and nutrient deprivation, which play a significant role in non-microscopic solid tumors. In this model, cells occupy sites of a 3D lattice and their division rate depends on the number of empty neighboring sites, hence replication is faster at the edge of the tumor. At each division, daughter cell occupies a site adjacent to the cell that divided, and both cells can gain new driver and passenger mutations with some probabilities. We also study the effects of migration and cell death on genetic heterogeneity of cancer.
B Waclaw, I Bozic et al. (2015) A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity. Nature 525, 261-264.
Mathematical models of resistance to cancer therapy
Acquired resistance to treatment is a major impediment to successful eradication of cancer. Patients presenting with early-stage cancers can often be cured surgically, but patients with metastatic disease must be treated with systemic therapies. Targeted therapies, a new class of drugs, inhibit specific molecules implicated in tumor development and are typically less harmful to normal cells compared with chemotherapy and radiation. In the case of many targeted treatments, patients initially have a dramatic response, only to be followed by a regrowth of most of their lesions several months later. I study mathematical evolutionary models of resistance to cancer therapy in order to quantify the dynamics of treatment and resistance and predict optimal treatment strategies.
1. Evolution of resistance to single targeted therapies
We studied the fully stochastic version of the Luria-Delbrück model, which was originally used to study the evolution of resistance in bacteria, to show that acquired resistance to EGFR-inhibitor panitumumab in colorectal cancer is a fait accompli, and due to a small preexisting resistant subpopulation. We also studied the effects of density limitations in tumor growth on the evolution of resistance to therapy, using a density-dependent generalization of a branching process. In our model, tumor growth is initially exponential, but slows as the tumor size increases, and the tumor eventually reaches a steady state. In this steady state, density constraints prevent further growth, unless new mutations arise that allow the tumor to overcome these constraints. After the tumor has been at steady state for time T, treatment is initiated, and sensitive cells decline exponentially. Resistance mutations can appear in any of the phases of tumor evolution (expansion, steady state or treatment) and can be selectively neutral or deleterious before treatment. We calculate the overall probability of tumor eradication and time until there is probability p that all sensitive cells have been eradicated.
I Bozic, B Allen and MA Nowak (2012) Dynamics of targeted cancer therapy. Trends in Molecular Medicine 18, 311-316.
LA Diaz Jr, R Williams, J Wu, J R Hecht, J Berlin, B Allen, I Bozic et al. (2012) The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486, 537-540.
2. Evolution of resistance to combination therapy
Combination targeted therapies are widely believed to be the one of the best hopes for achieving long-term remissions in cancer patients. We study a mathematical model for the evolution of resistance to combination targeted therapy in order to critically evaluate the potential and limitations of such therapies in actual disease settings. Our model is based on a multitype branching process and includes cells sensitive and resistant to each of the drugs in the combination. We derive formulas for the probability that cells resistant to all drugs exist at the start of therapy, expected number of such cells, and the overall probability of treatment success. To obtain key parameters for the model, we studied the dynamics of 68 index lesions in 20 melanoma patients receiving the BRAF inhibitor vemurafenib. To determine the total extent of disease in typical patients who enroll for clinical trials, we quantified all radiographically detectable metastases in 22 independent patients, seven with pancreatic ductal adenocarcinomas, eleven with colorectal carcinomas, and six with melanomas.
We find that combination therapy will not lead to long-term disease control in most patients if there is even one possible mutation that has the potential to cause cross-resistance to the administered drugs. In other words, if any of the 6.6 billion base pairs in a typical diploid cell can be mutated to a form that causes cross-resistance, the effects of combination therapy will not be dramatically better than monotherapy. Moreover, even if there is no possibility of a mutation that could cause resistance to two drugs, dual therapy will fail in patients with large disease burdens. In such cases, triple therapy will be needed – and this will only be successful if there is no possibility that a mutation could cause cross-resistance to all three drugs. Finally, we demonstrate that the current practice of administering targeted agents sequentially is a recipe for certain treatment failure and that simultaneous administration of targeted agents is essential for long-term disease control.
I Bozic*, JG Reiter*, B Allen* et al. (2013) Evolutionary dynamics of cancer in response to targeted combination therapy. eLife 2, e00747.
S Misale*, I Bozic* et al. (2015) Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers. Nature Communications 6, 8305.
3. Heterogeneity of resistance mutations
Failure of systemic cancer therapies is often due to a pre-existing resistant subpopulation of tumor cells, but little is known about genetic heterogeneity of this resistant subpopulation. We use mathematical modeling to study the evolution of resistance to anti-cancer treatment and describe for the first time the entire ensemble of resistant subclones in cancer therapy. We model the growth of a metastatic lesion as a branching process that starts from a single cell (the founder cell of the metastasis) that is sensitive to treatment. Sensitive cells divide with rate b and die with rate d. During cell division, one of the daughter cells receives a resistance mutation with probability u. Resistant mutations can be neutral in the absence of treatment, which means they have the same birth and death rates as sensitive cells, or they can be deleterious or advantageous, and we study all these cases. We label the resistance mutations that survive stochastic drift and establish a resistant subclone in their order of appearance and show that radiographically detectable lesions of solid malignancies contain multiple resistant subclones of comparable size. Surprisingly, we find that the ratio of the median numbers of cells in successive resistant subclones is independent of any model parameters: for example, the median of the second clone divided by the median of the first is √2 – 1. Finally, we show that our model is in excellent agreement with liquid biopsy data on resistance-associated mutations in colorectal cancer patients.
I Bozic and MA Nowak (2014) Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers. PNAS 111, 15964-15968.


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No one creates chemistry between Regency Historical characters better than Donna Hatch. If you want a "sweet" read, but with lots of sizzle, you have to read one of her books.
For new readers—what can they expect when they read your book(s)?
I always aim to provide a sweet, emotional romance interwoven with an accurate historical setting, with heroines readers admire, and heroes readers fall in love with. And I always promise a happily ever after.
How do you balance writing with the rest of your life?
It's sorta like juggling spinning plates--sometimes I do it well if I keep moving fast enough and sometimes I unintentionally let something fall. I try to write at least 100 words a day; sometimes I exceed that goal by a long shot but sometimes family, work, and other commitments don't make that possible, and I have learned to be okay with that.
Can you describe a typical writing day for you?
There is no typical day--it's grabbing writing time whenever I can get it. Most often I do it first thing in the morning after the kids have left for school and before I leave for work. Sometimes it happens during break at work. Sometimes, it's when I'm waiting to pick up a child from soccer or choir or orchestra. Sometimes it's late at night after everyone else is in bed.
Can you describe your writing space for us?
I most often write at the family desk in the dining room, which was converted into an office of sorts, or sometimes my work space is on my laptop whenever I think I can snatch a few minutes. I've stopped waiting for the perfect set up and learned to make anyplace into writing space.
What you are most passionate about outside of writing?
Besides my family? Music. I love music. I sing and play the harp and don't get to do either of them as much as I wish I could. I also love to ballroom dance but a foot injury has made that pretty much impossible now.
What genre(s) do you write? Why do you write the stories that you write?
I write romance, specifically Regency historical romance and fantasy with strong romantic elements. I love the Regency era and the people who lived then--it just seems to speak to me.
Do your characters come to you first, or the plot, or the world of the story?
Sometimes it's the plot and sometimes it's the characters. I even wrote a YA futuristic (so far unpublished) that started with the world and the characters evolved. We'll see how that goes.
What sets your books apart from other authors?
Even though I'm labeled a "sweet" romance writer, meaning no on-screen sex, I like a fairly high level of sensuality especially when it comes to the chemistry between the characters and that amazing first kiss. I also tend to go more into the darker, more tortured heroes than most sweet authors do. And I do a great deal of research so I can create a realistic feeling world rich with detail using only a few words describing the setting so it doesn't feel "info dumpy."
How do you go about developing your characters?
It's different with each of them but I spend a great deal of time learning about their personality, goals, backstory and what drives them so they feel well rounded, balanced and realistic, yet larger than life.
Out of all the characters that you've written, who is your favorite and why?
No fair! That's like choosing a favorite child. I love them all. They all have a special place in my heart.
Can you share a little of your current work?
I am working on a new series about a group of young men in Regency England who are proud of the fact that they are menaces to society. They will each meet their feminine match.
Where can readers find more information on you?
Amazon author page http://www.amazon.com/Donna-Hatch/e/B002BMG9KK/ref=sr_ntt_srch_lnk_2?qid=1348842851&sr=8-2
Can you list all your book titles so people can look for them?
The Rogue Hearts series: The Stranger She Married, The Guise of a Gentleman, A Perfect Secret. My fantasy romance: Queen in Exile.
Historical Anthologies:
Regency Hearts: "The Reluctant Bride," "Constant Hearts," "Emma's Dilemma"
A Timeless Romance Anthology: Winter Collection "A Winter's Knight"
Regency Short Stories:
Mistletoe Magic, Constant Hearts, Emma's Dilemma, The Reluctant Bride, Troubled Hearts
Here is an excerpt from my newest novel A Perfect Secret:
Tarrington Castle, England, autumn 1801
Six-year-old Christian Amesbury stood in the churchyard, trying not to crush the flowers he'd brought to put in front of the family crypt where they'd laid his brother to rest, the brother he loved, the brother he killed. Alone in every way, he stood, shaking, as his last taunting words to Jason echoed in his head. Christian had wanted to prove he was brave and strong. Instead, his brother, best friend, and advocate, was dead.
His throat tightened and tears blurred his vision. "I'm sorry, Jason," he whispered. "I'm so sorry. I miss you." He knelt and placed his offering of wildflowers in front of the crypt.
A drop of rain landed on his cheek and mingled with his tears. He stood, unmoving, embracing the desolation. He had no one to blame but himself. He'd never be happy again.
That horrific day three months ago had started out innocently enough, with Christian running with all his might after his older brothers, desperate to prove he wasn't a baby who should have stayed in the house with his sisters. As usual, he couldn't keep up as they raced to the tree. But one day he'd outrun them all.
Christian's brothers disappeared around a corner in the gardens, the shaking of shrubbery all that bespoke their passing. Drawing from some inner well of speed he didn't know he possessed, Christian darted around the corner and skidded on loose gravel. His feet went out from underneath him and he crashed to the ground. Pain burst from his thigh and elbow. Now, he would be last. Again. But he wouldn't quit.
Blinking back hot tears of humiliation, Christian scrambled to his feet and charged down the stone path toward Zeus's Garden. He flew headlong through the arch of roses, past statues, dodging fountains and flowers and shaped shrubbery.
His brothers' voices led Christian to their tree. Perfect for climbing with low, strong limbs spaced as evenly as a ladder, he'd imagined it as a pirate ship or sometimes a navy ship, a castle where a dragon lived, and a deep, dark dungeon filled with ogres.
Hanging from a branch, Grant mocked Christian. "Sorry, Chrissy, you're last. Go back home and sew and draw and play music with the girls."
Christian stuck his chin out. "I don't sew."
"Rules are rules," Jared said with a taunting smile. "Last one here has to go back and play with the twins. Maybe they'll put bows in your pretty blond hair."
"Aw, come on, let him stay." Jason's voice broke in. "Look, he fell and scraped up his leg and arm and didn't even cry."
" 'The perfectly perfect Christian' is too perfect to cry," Grant sneered.
Christian clamped his mouth shut as Grant taunted him with that all too familiar, sing-songy phrase that never failed to make his blood boil. He wasn't perfect, but he did try to be good for Mama's sake. Which was the only reason he didn't climb up the tree and punch Grant in the face.
"Let him stay," Jason urged again. "He's not bothering anyone."
Grant let out a snort. "You're too soft on him."
Cole, highest in the tree and holding a paper he'd rolled up into the shape of a spyglass, let out a long-suffering sigh. "You can be the cabin boy. Ahoy there!"
A ship, today.
From his perch on one of the lower tree limbs, Jason leaned down and held out a hand. "Come on up, Chris. I'll help you."
Christian shook his head. "I can do it by myself."
He would prove he could climb just as well as they could—without help. He stood below the lowest limb and jumped, his fingers curling around the branch as he caught it. After swinging his legs, he hooked his ankles around the limb and hoisted himself up.
"I'll bet you can't reach that one," Jared said to Cole, their voices filtering down from above like falling leaves.
"Watch me." Cole inched away from the trunk and tucked his feet below his body. After shifting into a crouch, his legs wobbling a little, he jumped toward an upper limb, and caught it. Within moments, Cole, Grant and Jason began leaping from limb to limb like sailors climbing the rigging of a ship.
Eyeing a branch far away from the others, Christian climbed. He'd jump to that far one, and prove he was as strong and able as the big boys. He ground his teeth against the throbbing pain in his elbow and leg, and hauled himself upward.
"Where are you going in such a hurry?" Jason put up an arm to block Christian's climb.
"Up there." Christian pointed to the isolated branch near the top. "I'm gonna jump to it."
Jason looked up. "That one up there? You're mad."
"I'll show you. Bet you can't jump to it."
Jason let out his breath slowly as he looked up. "That's a long way from the other branches."
Christian nodded. If Jason admitted he could never do it, even on a dare, and Christian did reach it, they'd see how big and brave he was. "I dare you to try."
Jason hesitated.
"You're too scared," Christian taunted. "But I'm not. I can do it."
Grant's voice cut in. "Jason's not scared of anything."
A bead of perspiration trickled down the side of Jason's face and his hand trembled as he wiped it away. He jumped. His body made a graceful arc, his legs straight, his arms reaching outward. The tip of his fingers grazed the coveted branch.
And slid off.
Jason fell.
Christian stared in horror as down, down, down Jason's twisting body plunged, slowly, like one of Christian's nightmares when it becomes impossible to run even when a monster is in pursuit. Someone screamed—a terrible keening noise that rent the air. Jason landed on the ground below with a thud that tore through Christian's body like a lightning strike. Jason lay unmoving.
All sound faded away except for the wild pounding of Christian's heart, and that terrible, terrible scream. Christian reached the ground without knowing how he got there. Faintly aware of searing pain in his hands, he collapsed on the ground beside Jason, reaching for him but terrified to touch him. Dizzy and out of breath, he gulped in air and the screaming stopped.
"Jason?" he rasped.
Other noises, other shapes, swarmed around him in a fog of confusion, but his vision fixed on Jason's chest struggling to rise.
Christian put his forehead on Jason's brow and wrapped his arms around his brother. "Jason, wake up. Open your eyes."
Jason's breathing grew more labored. He made a terrible rattle, then fell silent. All motion in Jason's chest stopped. Christian's own heart stopped. All the world stopped.
Someone peeled Christian off Jason and shoved him away. Voices, frantic and shrill, poured in all around him but he stood alone in a sea of horror. Adults shoved past him, crowding around Jason's motionless form. A dull roar built up in Christian's head drowning out everything but the image of Jason lying so still. Not moving. Not breathing. Not living. Somewhere the far reaches of his mind registered the knowledge that Jason would never open his eyes, never play, never laugh.
Someone shook Christian so hard that he bit his tongue. "What happened?"
Christian pushed back the suffocating fog. "He fell." His voice sounded far away as if someone else were talking through the other end of a hollow log. The truth wrenched out of him. "I dared him to jump. And he fell."
The ground had rushed up then, smashed Christian in the face, and had hurled him into darkness.
Another raindrop fell, jarring Christian back to the present. A moment later, the soft ping of raindrops pelted the roof of the crypt. Wiping his tears, he turned away, and stopped up short. Grant, as silent and dark as a shadow, glowered at him from the gate of the churchyard.
Christian glanced at the family coach waiting on the side of the road. The sound of Mama's weeping scraped against him like sandpaper on bare skin. Father's low voice as he tried to console her burned like lemon juice on an open sore.
He'd done this. He'd torn apart the family. It was his fault. Mama cried constantly and some days didn't get out of bed. Father never smiled. Two months later, Cole and Jared left for the sea. Jason was gone forever. Grant never spoke to him, only shot him murderous glares that left Christian constantly looking over his shoulder, half expecting to see a knife plunging toward his back.
Christian squared his shoulders and strode with dignity he didn't feel past gravestones and monuments. As he passed Grant at the gate, his brother spoke his first words to Christian in three months.
"I wish you were the one who had died."


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Questions and Answers with a CHCP
Dustin Ensign, CHCP is a Manager, Independent Medical Education working as part of Genentech's Learning & Clinical Integration Team. He achieved his CHCP designation as one of the December 2016 cohort of exam takers. Below, Dustin shares his experiences regarding becoming a CHCP.
Alliance: How long have you worked in CME?
Dustin Ensign (DE): I have been part of the CME industry since 2010. I still remember my Alliance CME basics course those 6 years ago.
Alliance: What motivated you to pursue the CHCP credential?
DE: I was motivated to pursue the CHCP credential as part of a personal challenge. I knew years ago that I very much enjoyed working in this industry because I saw that what we do really have an impact; though I was rather new to the field and wanted to have proper tenure and training before attempting the exam. Recently, a colleague of mine was planning on taking the exam and we agreed to study hard and work together to pass it. The rest is history.
Alliance: What is the most important benefit being a CHCP to you as a CME professional?
DE: I am excited to join the ranks of other CHCP's who are actively impacting healthcare. The CHCP designation gives me a sense of accomplishment and provides me another reason to keep learning and being invested in my life-long career. I see it as a commitment to continuing the work of improving care for every patient.
Alliance: What value does your CHCP designation bring to your organization?
DE: Beyond the credibility it provides, I believe the CHCP designation acts a conversation starter. When colleagues ask me, "What is a CHCP?" I get to explain to them; which usually allows me to also share how we are making positive improvements in healthcare. It's something to be proud of.
Alliance: How did you prepare for the exam?
DE: I'd like to think my studying started in 2010; going to Alliance meetings, other industry summits, and attending educational programs over the years definitely contributed to an understanding of the space. In reality, my studying was about 2 weeks of intense self-directed learning, researching, and multiple educational study sessions. I wanted to learn more than I already thought I did. Honestly, the practice exam was extremely helpful to provide a baseline. It helped me to see the breadth of topics, and that motivated me to learn more and seek out additional knowledge. I even learned a few things that I will incorporate into my future work and development.
Alliance: What would you say to someone considering pursuing the CHCP designation?
DE: Pursuing the CHCP designation is definitely a personal decision, but one that has brought great pride to me personally and professionally. I don't think I would have felt comfortable taking the test without having spent the time and effort over the years being open to learning and growing. Having a supportive team, committed to my personal and professional growth, was imperative to my success as well. If you are passionate about the work we do, I would absolutely recommend joining the ranks of so many others who every day are contributing to making healthcare better for all. Thanks for this opportunity to share my story.


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text:
What we should do is extending the Qt class named QDialog that provides the standard implementation for a dialog. In our dialog we what to show the user a line edit (aka: input line) with a relative label that shows what he should input there, a couple of check boxes to specify some options, a couple of button to act or cancel the action.
Given that, we see that the class definition is quite strightforward, the only nuisance here is that Qt uses a few pseudo-keyword to implement some basic Qt concepts. The easier thing is having a look at the code and figure out what is the sense ot it.
So, here is our new class, a dialog that allow the user to pass a few parameters required by the application to perform a search:
#include <QtGui/QDialog>
class QCheckBox;
class QLabel;
class QLineEdit;
class QPushButton;
class DlgFind : public QDialog
DlgFind(QWidget* parent = 0); // 2.
signals: // 3.
void findNext(const QString& str, Qt::CaseSensitivity cs);
void findPrev(const QString& str, Qt::CaseSensitivity cs);
private slots: // 4.
void findClicked();
void enableBtnFind(const QString& text);
QHBoxLayout* createLayout(); // 5.
QLabel* label;
QLineEdit* what;
QCheckBox* cbCase;
QCheckBox* cbBack;
QPushButton* btnFind;
QPushButton* btnClose;
1. this macro is required by all the classes having signals or slots.
2. we could pass to the dialog constructor the pointer to another widget that will be considered as the parent. By default, no parent is assumed.
3. "signals" is a Qt macro, and it is used to identify the messages emitted by the dialog.
4. "slots" is another Qt macro, used to identify the member functions of this class that could be called in connection with the call to another function (that acts as a signal).
5. utility function to create the dialog layout. Not stricly a necessity, but I feel that it makes the code a bit clearer.
Let's have now a look at the code implementation for this class. Here is the complete source file, some notes follow:
#include <QtGui/QtGui> // 1.
#include "DlgFind.h"
DlgFind::DlgFind(QWidget* parent) : QDialog(parent)
label = new QLabel("Find &what:"); // 2.
what = new QLineEdit();
label->setBuddy(what); // 3.
cbCase = new QCheckBox("Match &case");
cbBack = new QCheckBox("Search &backward");
btnFind = new QPushButton("&Find"); // 4.
btnClose = new QPushButton("Close");
// 5.
connect(what, SIGNAL(textChanged(const QString&)), this, SLOT(enableBtnFind(const QString&)));
connect(btnFind, SIGNAL(clicked()), this, SLOT(findClicked()));
connect(btnClose, SIGNAL(clicked()), this, SLOT(close()));
setFixedHeight(sizeHint().height()); // 6.
QHBoxLayout* DlgFind::createLayout() // 7.
QHBoxLayout* topLeft = new QHBoxLayout();
QVBoxLayout* left = new QVBoxLayout();
QVBoxLayout* right = new QVBoxLayout();
QHBoxLayout* main = new QHBoxLayout();
return main;
void DlgFind::findClicked() // 8.
QString text = what->text();
Qt::CaseSensitivity cs = cbCase->isChecked() ? Qt::CaseSensitive : Qt::CaseInsensitive;
emit findPrev(text, cs);
emit findNext(text, cs);
void DlgFind::enableBtnFind(const QString& text) // 9.
1. actually, this include is just laziness. It means "include any Qt core and GUI components", and usually this is a bit of overkilling.
2. Jasmin & Mark suggest that it is a good habit to use the function tr() for marking the strings that have to be translated. But I am quite sure I don't want to internationalize this application. Notice the ampersand to specify which letter is shortcut for the widget.
3. the label has a shortcut, the line edit is a buddy of the label so, when we press the key for the label we get in focus its buddy.
4. the Find button is the default one (selected when we press enter) and initially disable - so we can't give the order to find something before we specify what we want to find.
5. a delicate spot in the class: here we connect signals and slots. When textChanged() is called on what, we want enableBtnFind() to be called on this. When btnFind is clicked, findClicked() on this. And when btnClose is clicked we want to close the dialog.
6. our dialog has fixed height, but variable width. You can have (a limited) fun resizing it.
7. the idea of the layout for this dialog having a first box, topLeft, horizontally organized for the label and the line; a second box, left, that contains vertically the first one and the two check boxes; a third, right, for the buttons and a space to fill the gap, again vertically; and finally a big box in which we put left and right horizontally side by side. Quite boring to do this programmatically, isn't it? Luckly this is not the only way to do it.
8. that's the slot we call when the user click on the Find button. He could click it only if he has already put something in the line edit, so just have to check the other options the user has specified using the check boxes and emit the relative signal. Notice that currently there is no definition for our signals, so what happens is just nothing.
9. and this is the slot for the changes in the text of our line edit. We check the text passed and we enable or disable the button accordingly.
A good thing about using Qt Creator is that we can just compile this stuff and run it. If we are using another IDE that doesn't know enough about Qt we need an intermediate step before we can see the result of our job, since there is a bit of code that Qt should generate to manage all this signal-slot business and it is put in a "moc" file. So, that file has to be generated and added to the makefile for the project. If your IDE doesn't do that for you directly you should help it running by hand qmake. Otherwise you get some error like "unresolved external symbol" (for VC++) for a qt_metacall() guy.
I wrote this post as homework while reading "C++ GUI Programming with Qt 4, Second Edition" by Jasmin Blanchette and Mark Summerfield.


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Victoria Secret sent me an email "Do Laundry...or get new 7 for $26.50 panties." I have to say that Victoria Secret is a mind reader. I got an email yesterday and today is laundry day! I did both!!
I have to say looking for deals is a new addiction for me, honestly I got so happy when I saw that. I also got a follow up email that between 10am and 12pm they were doing 8 for $26.50!! It was such a good deal I couldn't pass it up. I know that's a bit pricey for underwear but it's the cuteness and quality I'm paying for. When the underwear is usually 5 for $26.50 they do 8 it's a must do!
Another great thing about Now until Sept 1st is that you get DOUBLE angel points on all panties!! That means I have 52 points, which puts me that much closer to my angel reward money!!
I picked up these pretties!
If Shopping online use code: PARTYON for 7 for $26.50 panties.
I also couldn't not stop at the outlet Bath and Body Works that was conveniently only 4 stores away in the mall. I also had a coupon code for a mystery discount. It ended up giving me a 36% off discount.
I got a new wall freshener for Fall as well as the two packs one sale for $6.99. Also my favorite fall candle minis were on sale for $1.99 which I couldn't say no to. I used my Angel card which also got me 17 more points!
I think I did pretty well for myself today! I love sales! Did anyone catch any good sales lately?


text:
Parents should call the attendance office 609.806.4280 x 3806 between 7:00 AM and 8:30 AM to report absences for their children in advance. In addition, a student returning from an absence must bring a note from a parent/guardian or a physician to the attendance office (located outside the Main Office). If a note is received within 3 days, the absence will be listed as "verified". Verified absences are counted toward the total for denial of credit.
Parents should dial 609.806.4266 and then choose their child's school from the menu:
A recording will ask you to give the following info:
Your child's first and last name
Your child's grade
Your child's home address
The date(s) your child will be absent
The reason for your child's absence (Please give a thorough explanation. If your child is sick, please let us know what symptoms they are experiencing so that we can monitor possible flu cases or other contagious illnesses.)


text:
Product Description
- *
- TESCO Non Bio Laundry Gel 540ml
- Dermatologically tested to be gentle on sensitive skin. Brilliant cleaning even at 15°C
Tesco non bio laundry gel contains amongst other ingredients: More than 30% Anionic Surfactants, 5-15% Non-Ionic Surfactants, Soap, Less than 5% Phosphonates, Also contains: Optical Brightener, Perfume
Store in a cool, dry place and away from direct sunlight. Do not store below 4°C.
Produced in
- 4-5 Kg Load Soiling Water Hardness Light laundry soiling Medium laundry soiling Heavy laundry soiling Soft/Medium 30mL 30mL 30mL Hard 30mL 30mL 35mL Hand wash NOT RECOMMENDED FOR HANDWASHING. 6-8 Kg load Maximum: Fill the inner part of the dosing device to the top 1 dose = 30ml *Standard washes based on normal soiling/medium water hardness
Name and address
- Tesco Stores Ltd.,
- Welwyn Garden City AL7 1GA,
- For best results, gel should be added directly to the drum using the dosing device provided. Do not add via washing machine drawer. Do not pre-wash. Pour gel into dosing device to the line. Place the dosing device on top of pre-sorted clothes and towards the back of the drum. Set machine running on the appropriate cycle for your clothing. Reseal the bottle and store upright. Do not put the dosing device into the dryer, and remove before the drying cycle of combination washer/dryers. Opening Instructions Remove dosing device, open lid and squeeze required amount of gel into the device. Close cap.
Net Contents
540ml e
Safety information
TESCO non bio LAUNDRY GEL
Contains MEA-C10-13 ALKYL BENZENESULFONATE Contains SODIUM LAURETH SULFATE Contains C12-18 PARETH-7 Contains C14-15 PARETH-7
- Corrosive
DANGER, Causes serious eye damage., Harmful to aquatic life with long lasting effects., If medical advice is needed, have product container or label at hand., Keep out of reach of children., Read label before use., Avoid release to the environment., Wear eye protection., IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing., Immediately call a POISON CENTER/doctor., Dispose of contents/container in accordance with local requirements for domestic waste disposal., Produced in Belgium for, Tesco Stores Ltd., Welwyn Garden City AL7 1GA, U.K. (c) Tesco 2017 SCCE1156, Freephone 0800 50 55 55, Mon-Sat, 9am-6pm., (NB Graphics - please use above and ignore auto Tesco contact details), 540 ml e
Using Product Information
While every care has been taken to ensure product information is correct, food products are constantly being reformulated, so ingredients, nutrition content, dietary and allergens may change. You should always read the product label and not rely solely on the information provided on the website.
If you have any queries, or you'd like advice on any Tesco brand products, please contact Tesco Customer Services, or the product manufacturer if not a Tesco brand product.
Although product information is regularly updated, Tesco is unable to accept liability for any incorrect information. This does not affect your statutory rights.
This information is supplied for personal use only, and may not be reproduced in any way without the prior consent of Tesco Stores Limited nor without due acknowledgement.
Tesco © Copyright 2019


text:
G-Whiz: Google Pittsburgh
Tech giant Google has moved into its new location in Bakery Square and is searching for brilliant minds.
Photo by Laura Petrilla
(page 1 of 2)
Google: A dozen years ago, it wasn't even a word yet. In 1997, Sergey Brin and Larry Page dreamed up this play on the word "googol," which is the mathematical term for 1 followed by 100 zeroes. The rest of us didn't hear it until the following year, when their oddly named search engine debuted, and the world took notice. Today, this high-tech giant has become stunningly central to the lives of people all over the globe.
More than 150 employees are now working for Google at its new Pittsburgh office, and the company is actively recruiting more. But what does it mean for the Pittsburgh region now that Google is here?
What began in 2006 as a two-person team located at the Collaborative Innovation Center (CIC) at Carnegie Mellon University has expanded into a thriving corporate office. In December, Google moved to East Liberty's new Bakery Square in order to accommodate the company's growing roster of talent in the area. Then just one month later, Google announced that it will expand its space in the complex by an additional 70,000 feet, clearing room for up to 350 more potential employees.
For comparison, the Pittsburgh office is slightly smaller than Google Boston and slightly larger than Google Boulder in Colorado. CMU president Jared Cohon described the expansion as "a great new chapter in Pittsburgh's future."


text:
Assassin´s Creed: Freedom Cry Discussion
Trainer Tools and Resources
I wonder went askew here? The trainers for the main game have worked like a charm since day one.
So is this one basically a lost cause?
I wonder went askew here? The trainers for the main game have worked like a charm since day one.
You are using the freedom cry DLC and not standalone version am I correct? I'm quite sure that is the issue.
The trainer is looking for the process: ACFC(.exe)
Isn't FC a standalone DLC? Not sure why you guys have the AC4 executable running. You can try to rename the executable but I'm not really sure if it will work.
What they are saying so far is that they are trying to use this trainer by launching Black Flag then select the Freedom Cry, what this trainer is for is the stand alone version only not the DLC for Black flag.
[Edited by DubaDuba101, 7/10/2016 5:45:57 PM]
* Updated game trainers and cheats daily
* Get notified when new cheats are added
* Request which games get new trainers
* Priority support with any problem
firewall and other security software.
on trainer and game.
version and distribution.


text:
Kingsmill's "Ultimate Family Fun Package"
July 4th may be over, but there are still 66 days left of summer to enjoy! Kingsmill, Williamsburg's premiere resort, has an exciting summer package you might be interested in. Located minutes from Colonial Williamsburg, Busch Gardens and Water Country USA, Kingsmill is guaranteed to please visitors of all ages.
Starting at $105 per person/night, Kingsmill's Ultimate Family Fun Package includes accommodations in a standard guest room (upgrade to one- to three-bedroom suites featuring a full kitchen and washer/dryer available), daily breakfast and length of stay tickets for popular nearby attractions.
To simplify ground transportation and avoid costly parking fees, the package offers complimentary shuttle service to and from Colonial Williamsburg and Busch Gardens.
Don't feel like leaving the resort? At Kingsmill, there is something for everyone. Guests who book the Ultimate Family Fun Package will receive access to Kingsmill's tennis club, golf clinics, indoor/outdoor pools and lazy river, fitness center and complimentary non-motorized water sports and fishing pole rentals.
As well, golf enthusiasts receive discounted rates on Kingsmill's renowned Plantation Course with the Ultimate Family Fun Package. Travel is valid through September 2.
To learn more, visit www.kingsmill.com


text:
Color Management Conference Keynote Announced: Todd Storbeck of Hallmark Cards
Tuesday, October 02, 2007
Press release from the issuing companyPittsburgh, PA, October 1, 2007-PIA/GATF's 2007 Color Management Conference, December 9-11, in Phoenix, Arizona, will feature a keynote presentation by Todd Storbeck, senior publishing professional and part of the advancing technologies team at Hallmark Cards, Inc. The presentation is entitled "Delivering the Vision for Desktop Color Reproduction at Hallmark Cards."
Hallmark's legacy for quality color reproductions is not easy to accomplish with off-the-shelf solutions alone. For the past 23 years, Storbeck has helped develop many proprietary software and hardware solutions to simplify Hallmark's complex, multicolor printing systems and digital workflows. The result of Storbeck's and the entire advancing technologies team's efforts is a color reproduction workflow that is a transparent part of the design process, helping Hallmark to bridge the gap between creative color intent and the final printed product.
Storbeck's presentation at the Color Management Conference will share a brief history of Hallmark's wide-gamut, fluorescent, multicolor printing ink systems and discuss some of the technical hurdles that were required to help significantly reduce costs, increase speed, and provide flexibility in the production workflows for all of Hallmarks' ink-on-paper products.
The PIA/GATF Color Management Conference, now in its ninth year, provides attendees with expert advice on how to select the right technologies and learn best practices to take home and put to work immediately.
This conference is for beginners and experts alike and appeals not only to traditional printers but also to packaging professionals, prepress workers, graphic designers, photographers, and digital printers. This year's Color Management Conference is organized into six tracks:
Creative Professionals
Digital Printing and Display Graphics
New to Color Management
Packaging Professionals
Prepress and Proofing
For more information about the 2007 PIA/GATF Color Management Conference, visit www.colormanagementconference.com or contact Gwen Martin at 800-910-4283, ext. 713 or firstname.lastname@example.com.
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