text: COLLEGE BASEBALL Red-hot ND hosts Purdue Now fourth in the nation for winning percentage, Notre Dame tries for its 24th consecutive baseball victory tonight when Purdue visits Eck Stadium at 7. The Irish are 32-8 for an .800 percentage. They trail only Nebraska (32-6, .842), Old Dominion (35-8, 814) and North Carolina (34-8, .810). Notre Dame is also seventh in total victories. Rice and Old Dominion have 35, Virginia and North Carolina 34, Florida State and Charleston 33. Sophomore left-hander Wade Korpi (4-1) is Notre Dame's scheduled starting pitcher. Korpi has struck out 58 and walked 15 in 45 innings for a 1.80 ERA. Purdue's 21-14 record includes an 8-8 mark in the Big Ten. Former John Glenn High School pitcher Andy Groves could see some action for the Boilermakers, although he pitched eight innings of scoreless relief against Michigan on Friday. He struck out a career high seven. He has no record in 36 innings, all in relief, and owns a 1.50 ERA. COLLEGE SOFTBALL Boilers boast ex-Penn star Former Penn softball standout Tiffany Krcelich will have a homecoming Wednesday. Krcelich's Purdue squad will pay a visit to Notre Dame for a twinbill. The first game is slated for a 4 p.m. first pitch at Ivy Field. Krcelich, a sophomore outfielder, is hitting .298 for Purdue. She has started 52 games and has 25 runs scored, 13 RBI, six stolen bases and three doubles. Krcelich was a first-team All-NIC choice and second-team All-State pick in 2004 after leading Penn to a sectional title. Krcelich is one of six Indiana players on the Purdue roster. Also playing for the Boilers is junior pitcher Brooke Baker, a former star at Lake Central. Purdue brings a 27-27 overall mark and 5-10 Big Ten record, into Wednesday's games. Notre Dame, which won 4-1 at Purdue in 2005, stands at 31-13 prior to a game at Valparaiso today. Pilot players earn honors Bethel's Britney Beneker, Laura Keech, Christy Nagy, and Somer Stilley were all named to the 2006 North Central All-Region softball team by the National Christian College Athletic Association. Beneker, a junior short stop, has a batting average of .469 with 12 home runs, 26 stolen bases, and 45 RBIs. Keech, a freshman outfielder, carries a .367 batting average with 34 RBIs and has scored 42 runs. She sits second in the NIA with 18 doubles. Nagy, a junior center fielder, has a batting average of .323. She holds the Pilot single season record and leads the NAIA with 45 stolen bases. Stilley, a junior hurler, has accumulated an 18-7 record with an ERA of 0.78. She has 117 strikeouts this season. COLLEGE GOLF Irish women in fourth The Notre Dame women's golf team finds itself in fourth-place after the first day of play at the Big East Championship at the par 72, 5,968-yard Lake Jovita Golf and Country Club in Dade City, Fla. The Fighting Irish posted a 304 (+16) in Monday morning's first round and followed that up with a 316 (+28) in the afternoon for a 620 total. Junior Noriko Nakazaki carded a team-best five-over par 149 (71-78) on the day for the Irish and is tied for fourth overall. Louisville leads the seven-team field with a 590 (+14). Team Scores (36-hole totals): 1. Louisville 590 (296-294), 2. Georgetown 603 (308-295), 3. South Florida 616 (303, 313), 4. Notre Dame 620 (304-316), 5. Cincinnati 625 (312-313), 6. Rutgers 634 (316-318), 7. St. John's 640 (320-320). Top-5 Golfers (out of 35) (36-hole totals): 1. Adrienne White (Louisville) 143 (74-69), 2. Cindy LaCrosse (Louisville) 146 (72-74), 3. Cristina Gonzalez (Louisville) 148 (73-75), 4t. Christy Larrimore (Georgetown) 149 (76-73), 4t. Noriko Nakazaki (Notre Dame) 149 (71-78). Notre Dame Scores (36-hole totals): 4t. Noriko Nakazaki 149 (71-78), 11t. Lauren Gebauer 153 (74-79), 15t. Katie Brophy 156 (77-79), 28t. Suzie Hayes 162 (82-80), 33t. Lisa Maunu 169 (82-87). Irish men in third place Notre Dame finds itself in third place at six-under par 570 (281-289) following Monday's first two rounds of action at the 2006 Big East Conference Men's Golf Championship at Lake Jovita in Dade City, Fla. Among the school records the Irish set or tied on Monday was a new school postseason mark with their opening-round 281 (also the third-lowest round in school history), and a new Notre Dame standard with its 36-hole score, obliterating the old standard by 11 strokes (581, set at the 1968 Notre Dame Invitational and tied in last year's dual match vs. TCU). TEAM SCORES (36-hole totals): 1. Louisville 558 (279-279); 2. Marquette 563 (285-278); 3. Notre Dame 570 (281-289); 4. South Florida 573 (289-284); 5. Villanova 586 (297-289); 6. St. John's 589 (301-288); 7. (tie) DePaul 594 (297-297) and Connecticut 594 (308-286); 9. Cincinnati 595 (300-295); 10. (tie) Rutgers 599 (298-301) and Georgetown 599 (302-297); 12. Seton Hall 610 (311-299). TOP FOUR INDIVIDUALS PLUS NOTRE DAME GOLFERS (of 60): 1. Derek Fathauer (Louisville) 132 (66-66); 2. Joe Weber (Marquette) 135 (67-68); 3. Keegan Bradley (St. John's) 140 (71-69); 4. (tie) Josh Sandman (Notre Dame) 141 (70-71); 10. (tie) Cole Isban (Notre Dame) 142 (70-72); 22. (tie) Mark Baldwin (Notre Dame) 146 (69-77) and Scott Gustafson (Notre Dame) 146 (75-71); 25. (tie) Tommy Balderston (Notre Dame) 147 (72-75). COLLEGE BASKETBALL Doherty takes over at SMU SMU hired former national coach of the year Matt Doherty on Monday to try reviving a program that hasn't gone to the NCAA tournament in 13 years. Doherty signed a five-year deal, but terms weren't disclosed. Doherty, coming off a 15-13 season at Florida Atlantic, replaces Jimmy Tubbs, who was fired April 6 after two losing seasons and an internal investigation that uncovered NCAA violations. "I look at this as a destination job," Doherty said. "I didn't want to take a job to take another job." Doherty, who won a national championship as a player for North Carolina, broke into coaching with Notre Dame in 1999-2000. He took over the Tar Heels the next season and earned the coach of the year award from The Associated Press for going 26-7 and winning a share of the regular-season ACC title. North Carolina missed the NCAA field the next two years, and Doherty resigned under pressure in April 2003. He worked as a television analyst for two years, then spent this past season at Florida Atlantic. PRO FOOTBALL Colts re-sign LB Cato June Linebacker Cato June, a Pro Bowl starter who led the Indianapolis Colts with five pass interceptions last season, signed a new contract Monday for one year at $1.57 million. His agent said June still wants a long-term deal with the Colts. "The guy's a young, ascending Pro Bowl player, and it would be in the team's best interest to get a deal done as soon as possible," agent Brian Mackler said. "If they don't, then there are 31 other teams, as we found out with David (Thornton), that will value what Cato does." GOLF Tiger wins stock car race Tiger Woods hunkered behind the wheel of his vehicle, its motor coughing noisily. One of the world's most visible athletes was suddenly unrecognizable under a flame-retardant suit, helmet and tinted visor. On Monday, the world's best golfer became a celebrity stock car racer. Woods, in New Zealand for the wedding of caddie Steve Williams, won the second of two celebrity stock car races on a dirt track in this small coal mining town 55 miles south of Auckland -- even after starting at the back of the field. Woods was a designated "blocker" in the first race, which also included several full-time V-8 circuit drivers. He started on the outside of the first row for the race in this branch of motorsports where crashes are not only legal, but often encouraged. His job was to prevent other cars from passing and reaching front-runners on his team, and Woods didn't finish among the leaders in the 12-lap race. In the second of two celebrity races organized by Williams through his Steve Williams Foundation to raise funds to provide sporting careers for disadvantaged youth, Woods forced his way from the back of the grid to the front. He took the lead on the sixth of 12 laps over a 400-meter oval, and, despite a crash into the wall which left his car sparking and tires smoking, he held on to win. Woods had no second thoughts when Williams asked him to take part. "I'm just so excited to be here," he said in greeting the capacity crowd of more than 7,000 that jammed the Huntly Placemakers Speedway.


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Entries in exhibition (8)
Everything Was Forever, Until It Was No More
Konrad Smoleński is an artist working in different fields, often collaborating with other artists and musicians. He works and lives in Warschau and Bern. His works are often big and sculptural, connected to sound or video.
His work "Everything Was Forever, Until It Was No More", is a sculptural instrument written for two bronze bells, two walls of loudspeakers and resonating objects, in this case resonating lockers. The composition links the rich symbolic sound of the clocks to the abstract sound of reverb and resonating noise. By using delay and other effects, Smoleński creates a world wherein history comes to a standstill.
This installation is one of many which can be seen at Orkest! a group exhibition featuring works by Rutger Zuydervelt, Julian Sartorius, Oliver Beer, Rubén D'hers, Michael Schmid, and Nicolas Field. Orkest! can be seen from the 7th of december 2014 until the 6th of march 2015 at the Netwerk / centre for Contemporary art in Aalst, Belgium. We'll feature some other works from this exhibition in the coming weeks.
Pendulum Sound Machine
Pendulum Sound Machine is a sound installation created by Kouichi Okamoto as part of an exhibition curated by Designboom, called Yakitate, which is Japanese for 'freshly baked'. This nice set of pendulums hanging over a record player should sound as good as it looks, but does it?
It really is one of those cases in which the form is well thought out, but the function is neglected. A plate just doesn't sound as well as a lot of other objects could.
The Transfinite
I have seen Ryoji Ikeda perform live once, and while his clean beeps and glitches might be best experienced on headphones (at least that's my opinion), the combination with his video work synchronized to the sound definitely creates a kind of hypnotic experience.
Ikeda was asked by the Park Avenue Armory, New York to expose his work in the huge Wade Thompson Drill Hall. So if you're in the neighborhood, you can visit The Transfinite, and if you do, I would love to hear about the experience!
Sound and Music in Museums
Last year at New Zealand's Auckland Museum visitors could enjoy the exhibitions while listening to music inspired by the historic and artistic artifacts. They called it the Sonic Museum. I missed it, but I still think it is worth a mention, as it crosses the bridge between the whisper quiet environment of museums on one hand and sound and music on the other.
Exhibiting sound art and installations as we see them a lot on Everyday Listening will create a completely different experience in a museum and should be handled with great care. I love the relative silence among a group of people as it feels like a way of paying respect to the works of art. That said, incorporating sound and music could change the way we perceive an exhibition and make it a more personal experience.
Was: More Washing Machines
Honestly, I was not planning on having a washing machine theme this week, but after The Drying Green I stumbled upon another piece of sound art which has to do with wet clothes and the sound of washing machines, and this time it is simply called Was.
In the installation, created by Wessel Westerveld and Lydia van de Streek, water keeps on dripping from the wet clothes onto the water on the floor, creating a concert of dripping sounds. The washing machine kicks in now and then, creating a low rumbling sound, and the installation keeps the clothes wet at all times.
I am sorry that I do not have a video of the installation to show you, but on Wessel Westerveld's website you can read more about his work and watch a few videos of his installations. Happy washing!
Sound in Context: Exhibiting Sound Art
When an architect designs a building, or a gallery space gets prepared to exhibit works of art, is the role of sound taken into consideration? What if the art in the exhibition consists of sound installations as opposed to visual arts? In Sound in Context, a short documentary by the Sound and Music organisation, the role of sound within the visual arts world is explored.
People like David Toop, Richard Whitelaw and Benedict Drew, among others, discuss the invisible nature of this time-based medium we are dealing with here, and how many curators and art experts are not used to it. Another subject they cover is the value of sound art. Can it be sold? In what way? Should an artist give away CDs with recordings of sound installations? A very interesting subject which makes Sound in Context an interesting documentary to watch, apart from the soporific way some of these sound artist tell their story (they are probably not used to be recorded in a visual way).
Akousmaflore: sensitive musical plants
One of the projects presented at the Futuresonic festival this week is Akousmaflore by Scenocosme from France. Akousmaflore is a small garden consisting of plants hanging from the ceiling. By touching the plants, or coming very close to them you cause them to produce sound. It's like an interactive garden.
The sounds come from speakers placed around the room, so it's not like each plant has its own speaker. This makes the plants like a musical interface rather than an instrument themselves. One of the aims of the project is to bridge the gap between nature and technology. It certainly creates a beautiful image, as you can see in this video:

subset: commoncrawl


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It may have been Christmas Day for much of the world, but it was just another 25th of the month for the Pinson family, which spent part of the day cleaning up the pedestrian walkway in Vallejo where Pearl Pinson was last seen alive — being abducted at gunpoint — on May 25, 2016.
The then-15-year-old was walking her regular route to the school bus when she was snatched by 19-year-old Fernando Castro, who witnesses say dragged her kicking and screaming across the overpass to his waiting car, and drove away with her.
The next day Castro was killed in a shoot-out in Santa Barbara County, but there was no sign of Pearl.
And that's where things stand today.
Pearl's parents, her sister, brother, a family friend and the parents of a former boyfriend come out to the overpass every 25th of the month and tend to the site. There's little else they can do, and this makes them feel like they're still connected, and like they're doing something for her, they said.
"We care. That's why we do it; my wife, Vickie (Francon) and I," Dan Walsh said. "Because we care. That's the only reason."
"Every month we either come here or to a favorite place of hers, like the Glen Cove Park or the baseball field at Wilson Park, and do something for her … a barbecue, or something," sister Rose Pinson said. "Last month, we planted a garden down here, but, you can see, it's all been torn out since then."
The small band finds graffiti and evidence of burning and other vandalism on the posters they have had made offering a $10,000 reward for Pearl's return, not to mention garbage and the refuse evidently left by homeless people finding shelter under the concrete structure.
Rose Pinson said police think Pearl may have been disappeared into human trafficking, and as horrible as that would be, it beats the alternative, she said.
"Honestly, we hope that's what it is," Rose Pinson said. "We'd rather have that than to find her not alive."
Pinson patriarch James Pinson said that while he's trying to remain positive, the realist in him tells him she's "no longer with us," while, Pearl's mother, Joyce Mitchell, said her heart tells her otherwise.
All any of these people say they want for Christmas — or any other time – is closure.
"Life has changed," James Pinson said. "I have a lot of hatred in me. Anyone who dares to do something to a child, I'd just as soon shoot 'em, and I don't care if I go to jail. This is our second Christmas without her, and the holidays have no meaning anymore. They used to be enjoyable, but now, it's just another day."
Rose Pinson said that her message to her sister, if she could get it to her, would be, "I love her and I'm not giving up, and she will be found, no matter how long it takes."
The Pinson family urges anyone who knows or even thinks they know anything about Pearl Pinson's whereabouts, to call the Pearl Pinson tip line at (925) 812-2059, or the police.
Contact Rachel Raskin-Zrihen at (707) 553-6824.


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NICs avoidance: sham: case law
There is judicial guidance on the meaning of sham, notably the case of Hitch & others v Stone [2001] EWCA Civ 63 (Hitch v Stone), particularly paragraphs 62 to 69. This guidance assists in the consideration of any potential sham argument.
To be a sham, all parties must intend some form of arrangements that are different to the ones as legally presented. At paragraph 63 of Hitch v Stone Lady Justice Arden states
"… It is of the essence of this type of sham transaction that the parties to a transaction intend to create one set of rights and obligations but do acts or enter into documents which they intend should give third parties, in this case the Revenue or the court, the appearance of creating different rights and obligations."
In other words, if the terms that actually bind the parties are the same as the terms as documented and presented to others, then it is not a sham arrangement.
Lady Justice Arden provides a helpful comment at paragraph 67 of Hitch v Stone, stating
"… the fact that the act or document is uncommercial, or even artificial, does not mean that it is a sham."
Equuscorp Pty Ltd v Glengallan Investments Pty Ltd [2004] HCA 55 is another notable case that gives guidance on the meaning of sham. The decision was after Hitch v Stone. At paragraph 46 sham is described as
"steps which take the form of a legally effective transaction but which the parties intend should not have the apparent, or any, legal consequences".


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Red Pants for the World is a project designed to support an army of young women living created lives, altering the planet. We are committed to all women living great lives despite their circumstances. Our first program is to support the women in rural Afghanistan.
Wednesday, November 10, 2010
Care2 Educate Girls in the World
Posted by Judi Romaine at 11:12 AM
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About Me
Judi Romaine
- Residing Bloomington, Indiana for twenty years, my life is about all people living created lives. I am a four book contracted fiction writer, a thirty-five year graduate of the work of transformation with Landmark Education and est, and I love my life, my fantastic daughter, Rudi and my ex-husband, Keith.


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Date(s) - Dec 31st 2017
3:00 pm - 9:00 pm
Historic Bethlehem Visitor Center
Categories No Categories
Rides run every 20 minutes
Tours leave from the Visitor Center & Museum Store at 505 Main Street
Witness the beauty of Bethlehem's downtown National Historic Landmark District with a Christmas carriage ride. Carriages seat four people, making this experience an intimate way to experience Bethlehem and make this Christmas special. Special restrictions may apply.


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Taking stock of numbers
Numbers dominate our world - but how much do they really tell us? Nate Silver, who successfully forecast the US presidential election, tells us why we can't count on statistics.
Numbers are a relatively modern invention. The best estimates suggest they are only about 10,000 years old, yet numbers have come to dominate our lives. We now attempt to measure virtually everything using them.
But numbers are only meaningful if they are accurate, as Argentina is discovering. There's growing protest on the streets, driven in part by an economy that many say is grinding to a halt. Opponents of populist, left-leaning President Cristina Kirchner say she's covering up how bad it is by manipulating the numbers. Ed Butler reports from Buenos Aires.
Nate Silver, the man who successfully forecast the result of every state in this year's US presidential election, tells us why we can't count on statistics.
Some say there are benefits in wasting what is arguably our most precious commodity - time. They say a bit of idle dreaming makes you more efficient at work. Our regular commentator, Lucy Kellaway of the Financial Times, has been mastering the skill of wasting time.
(Image: A stock exchange board, Credit: AFP/Getty Images)
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- Tue 11 Dec 2012 08:32GMT
- Tue 11 Dec 2012 13:32GMT


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Solution Key Problem Set 3
- Luke Glenn
- 2 years ago
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1 Solution Key Problem Set 3 Question 1 The following human pedigree shows the inheritance pattern of a specific disease within a family. Assume that the individuals marrying into the family for all generations (except the parental generation) do not have the allele associated with the disease phenotype and that no other mutation arises spontaneously. Also assume complete penetrance. 1 affected female Unaffected female 2 3 affected male Unaffected male 1 st Pedigree 4 5 a) Circle the most likely mode of inheritance for this disease. Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. b) Write all possible genotypes of the following individuals in the pedigree. Use the uppercase A or X A for the allele associated with the dominant phenotype and lowercase a or X a for the allele associated with the recessive phenotype. Genotype(s) of Individual 2: AA, Aa Genotype(s) of Individual 4: Aa c) What is the probability that Individual 5 will be a carrier? 50% d) The following human pedigree shows a family affected by a different disease. Assume that the individuals marrying into the family do not carry any allele associated with the affected phenotype and that no other mutation spontaneously occurs. Also assume complete penetrance 6 2 nd Pedigree Note: Use the notation such as R or X R for the allele associated with the dominant phenotype and r or X r for the allele associated with the recessive phenotype. Individual 3 from the 1 st pedigree has a second marriage with Individual 6 from the 2 nd pedigree. They have a son and a daughter as shown below. Individual 3 from 1 st Pedigree?? Individual 6 from 2 nd Pedigree i. What would be the genotype of their son for the two genes? X r YAa ii. What would be the genotype of their daughter for the two genes? X R X r Aa 1
2 Question 2 You are analyzing the following human pedigree. Assume that the individuals marrying into the family (except the parental generation) do not carry any allele associated with the disease phenotype and that no other mutation spontaneously occurs. Also assume complete penetrance. Use the letter R or X R for the allele associated with the dominant phenotype, r or X r for the allele associated with the recessive phenotype. 1 2 affected female Unaffected female 3 affected male Unaffected male?? A B a) Circle the most likely mode of inheritance of this disease? Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. b) List all possible genotypes of the following individuals in the pedigree. Genotype(s) of Individual 1: X R X R or X R X r Genotype(s) of Individual 3: X R X r c) What is the probability of Individual A being affected? 25% d) What is the probability of Individual B being affected? 25% Question 3 Shown below is the schematic of a replicating DNA in a bacterial cell Region 1 Region 2 Origin a) On the diagram, label the 5 and the 3 ends of the parental DNA strands. b) Identify the strand(s) (choose from Top, bottom, both or neither) 2 i. Which serves as a template for the synthesis of a continuous strand in Region 2. Bottom
3 Question 3 continued i. Which will not replicate if the cells have a non-functional helicase in Regions 1 & 2. Explain why you selected this option. If the helicase is non-functional the two strands of DNA duplex will not unwind and hence will not be available to serve as the templates for the synthesis of the complementary strand strands. So neither the top nor the bottom strand in region 1 and Region 2 will be able to replicate. c) To which site (A or B or both) can primer 5 AACG3 bind during replication? Site B d) Each replication cycle, during each cell division in eukaryotes, results in the shortening of chromosomal ends. This process is slowed down by the action of telomerase enzyme that adds telomere repeats (5 TTAGGG3 ) to the chromosomal ends. Explain how the telomerase activity may regulate the number of mitotic divisions a cell can have during its lifetime. In the absence of a functional telomerase in adult somatic cells, the chromosomal ends continue to shorten with each cell division. This eventually results in the loss of genetic information, which is crucial for cell division and survival. Question 4 The following schematic shows the chromosomal location of Gene 1 and Gene 2. The corresponding promoters for Gene 1 (p1) and Gene 2 (p2) are shown. a) On the schematic, use arrows to show the direction of transcription of Gene 1 and Gene 2. b) The following is the partial DNA sequence of Gene 1. Note: The underlined sequence (from position 20-54) represents the promoter for Gene 1 and the underlined and italicized sequence (from position represents its ribosomal binding (RBS) site. Transcription begins at and includes the bold T (Top)/A (bottom) base pair at position 60. i. Which strand (Top/ bottom) is the template strand for transcription of Gene 1? Bottom strand ii. What are the first 6 nucleotides of the mrna transcribed from Gene 1? 5 UAGGCU3 3
4 iii. What are the first 4 amino acids encoded by Gene 1? N-met-arg-arg-leu-C Question 4 continued c) You have found mutant alleles of Gene 1 that have insertion of the following three base pairs immediately after the C/G base pair at positions, 70, 100 and 150. Complete the table below for each of the following mutations. 5 CGA 3 3 GCT 5 Positions of insertions of the above sequence After 70 th base pair After 100 th base pair After 150 th base pair Effect on the length of protein Same as the original Same as the original Longer than the original (longer than/ shorter than/ same as protein since the insertion protein. Although this protein by one amino acid the protein produced by the wild- of the bases is prior to the insertion is after the since it is after the start type allele of Gene 1). Explain. ribosomal binding site. ribosomal binding site it is prior to the start codon and hence is not a part of the open reading frame. codon. But it does not change the reading frame. If the protein is produced, will Yes, since the translation Yes, since the translation Functional, if the extra it be functional? Explain. of the protein following this insertion remains unaffected for the reasons described above. of the protein following this insertion remains unaffected for the reasons described above. amino acid does not change the 3D conformation of the protein. Inactive if you do not make this assumption. d) Chromatin is a dynamic structure comprised of DNA and histone proteins. Chemical modifications of histones affect state of chromatin condensation and gene transcription. More than a fifth of histone s amino acids are lysine and arginine. Explain why this is crucial to the packing of DNA. The DNA is negatively charged due to the phosphates in the sugar phosphate backbone. Therefore it is most likely to interact with the amino acids that are polar and have positively charged side-chains. e) The schematic below represents the chromatin in a condensed or loosened state. Histone tails DNA duplex Histones modifications Nucleosomes (end view) in condensed chromatin Loosened chromatin structure i. Which of the above states (condensed/ loosened) represents a replicating DNA molecule? ii. Which of the above states (condensed/ loosened) represents the DNA that is being transcribed? iii. Which state (condensed / loosened) of chromatin would you expect to see in a cell that has been treated with DNA methylase that adds methyl groups to the cytosine bases in the promoter region of a gene? Explain why you selected this option. The chromatin will be in the condensed. So the promoter will not be available to bind to the RNA polymerase and other factors that are a part of the transcription initiation complex thus resulting in in inhibited or reduced transcription i.e. transcription silencing. 4
5 Question 5 You are looking at the sequence of a eukaryotic gene that encodes a small peptide. Part of the promoter specific for this gene is indicated by the boxed sequence and the direction of transcription is shown by an arrow. Transcription starts at and includes the bold and underlined A/T (top strand/bottom strand) base pair. #2 #3 #1 5 -XXXXXXTGTCCGTATAATATTGTGAGATGTTATATCCCGCCGTCAACACCATCAAACAGGATAATCGCTGACTGG-3 3 -XXXXXXACAGGCATATTATAACACTCTACAATATAGGGCGGCAGTTGTGGTAGTTTGTCCTATTAGCGACTGACC-5 a) Give the mrna sequence of the first 15 bases transcribed from this gene and label its 5 and 3 ends. 5 AUAUUGUGAGAUGUU3 b) Give the first five amino acids of the peptide that would be translated from the mrna for this gene and label its N and C ends? 5 met- leu- tyr-pro-ala-c c) Give the base sequence and label the 5 and the 3 ends of the anti-codon on the trna that inserts the 2nd amino acid into the nascent polypeptide. The 2 nd codon is 5 UUA3 so the corresponding anticodon on the trna should be 3 AAU3 and the codon anticodon should undergo complementary base pairing. d) Would a 3 rd base substitution within the codon for the second amino acid in the above mrna transcript always change the resulting protein sequence? Explain your answer. No. Leucine is coded by six different codons. Any change in the third base of the codon would still result in leucine. In addition, if the first position has a change from U à C or C à U, the codons will still code of leucine. e) Do the italicized and underlined nucleotides TAA (shown in blue and indicated as #1) correspond to a stop codon for the peptide that is encoded by this gene? Briefly explain your answer. No, the TAA is not in frame so it does not correspond to a stop codon. f) For each of the following mutations, indicate how the change in the DNA alters the resulting peptide as it compares to the normal functioning peptide. Your choices are: longer than, shorter than, of the same size but different sequence, or no change compared to the normal functioning peptide. For each, explain your answer. i. You add an extra G/C (top strand/bottom strand) base pair after the A/T base pair that is shown in blue, italicized and labeled as #2. No change. The addition of the G/C base pair is upstream of the start of the first 5 AUG 3, so there will be no change in the peptide size or sequence. ii. The T/A base pair, which is shown in blue, italicized and labeled as #3, is changed to a G/C base pair. The addition of the T/A base pair results in a change from 5 UAU 3 to 5 UAG 3. This results in a premature stop codon so the peptide will be truncated. 5
6 Question 6 You are studying transcription in a plant whose leaves fluoresce blue in response to touch. You have the information that the TATA binding factor in this plant specifically binds to the 5 -TATAAT-3 sequence and recruits other components of the transcription apparatus to form a transcription initiation complex. Once RNA polymerase has bound to this region, it begins transcribing from the 25 th nucleotide downstream of 5 -TATAAT-3 sequence. a) You decide to examine the following segments of chromosomal DNA from this plant. For each of the sequences below box the template strand of the DNA. Chromosomal DNA segment I 5 -CCGATATAATGAGATGTCGTCTGGGCCTTCGGGTCTCGTTTGCGGTTCC-3 3 -GGCTATATTACTCTACAGCAGACCCGGAAGCCCAGAGCAAACGCCAAGG-5 Chromosomal DNA segment II 5 -GGCTTTAATGCTCTACAGCAGACCCGGAAGCCCAGATTATACCGGATCG-3 3 -CCGAAATTACGAGATGTCGTCTGGGCCTTCGGGTCTAATATGGCCTAGC-5 b) Following is an mrna transcript that encodes a small peptide. The start codon is shown in blue and the intron is shown in yellow and underlined GACUAAGAUGAUUUGGGCAAACACAGUGCACUUUCCCAGUUUGGCGAACGCCUGA-3 You create the following mutants. Circle the mutant from the choices below, which will generate a premature stop codon. i. The 6 th base in the above transcript was changed from A to U. ii. The 16 th base in the above transcript was changed from G to A iii. The 12 th base in the above transcript was changed from U to C. c) The fidelity of transcription is far less compared to replication. Explain why is this so. Also explain why the cell can tolerate the errors in transcription much better than the errors in replication. DNA polymerase has 3 -> 5 exonuclease activity that proofreads and repairs any mismatched base pair at the time of replication. If there is an error in replication, it gets repeated in all daughter cells and it results in incorrect mrna transcripts and presumably a non- functional proteins. However, when a gene is transcribed many mrna copies of the same mrna transcripts are produced some of which may have errors. These transcripts are short- lived meaning that the error in not persistent. Besides, even if there are some transcripts with errors the remaining mrna transcripts may produce protein that is sufficient for the normal functioning of the cell 6
7 U C A G Codon Chart (You can detach this page) U C A G UUU Phe (F) UUC UUA Leu (L) UUG CUU Leu (L) CUC CUA CUG AUU Ile (I) AUC AUA AUG Met (M) GUU Val (V) GUC GUA GUG UCU Ser (S) UCC UCA UCG CCU Pro (P) CCC CCA CCG ACU Thr (T) ACC ACA ACG GCU Ala (A) GCC GCA GCG UAU Tyr (Y) UAC UAA Stop UAG Stop CAU His (H) CAC CAA Gln (Q) CAG AAU Asn (N) AAC AAA Lys (K) AAG GAU Asp (D) GAC GAA Glu (E) GAG UGU Cys (C) UGC UGA Stop UGG Trp (W) CGU Arg (R) CGC CGA CGG AGU Ser (S) AGC AGA Arg (R) AGG GGU Gly (G) GGC GGA GGG 7
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Home Control of Gene Expression Gene Regulation Is Necessary? By switching genes off when they are not needed, cells can prevent resources from being wasted. There should be natural selection favoringMore information


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|What are you doing for Britain?
With the tea brewing we tucked into some oat and chocolate chip muffins. We tried to be good with some mini ones and there was a lot of discussion as to how many mini muffins equaled a large one ....I fear we are only kidding ourselves!
Sewing started with Janet trying out her new ruler Marti Michell log cabin ruler, she was using a now discontinued Moda Honeybun -1 and 1/2 inch strips- from a range called Wildflower Serenade II. She announced that it was a very easy ruler to use and that it made the process much quicker and more accurate. Always good to hear how a tool or new ruler has worked out. This will be a project to be sewn on her Featherweight. We look forward to seeing it finished and knowing Janet's prolific output I don't think it will be too long!
After a lunch of a chicken, chorizo and butter bean casserole served with salad and baked potatoes, we finished off with brownies and raspberries from the garden.
After all that, we all would have been quite happy to have a nap, but instead it was back to business. I had been preparing a block for a new quilt, from the book Country Inn by Blackbird Designs. The quilt is called Evening Bloom, I had seen one that had been completed and just loved it ....I mean what's not to love, there is applique and big blocks and flowers!
|Block one - The Tulip block
Amanda brought along her log cabin wallhanging, she was hoping to get some ideas on what design to use for quilting, the blues and browns looked so lovely. She has now decided so we are looking forward to seeing it completed.
She then got busy on more hexagons, it is amazing how they quickly mount up just doing a few at a time. it is always fun to see the containers that people use to keep their hexie projects in and how they change as the hexies grow and grow.


text: 1. IB has an Excel-type worksheet where you can jump from stock to stock, and order to order. Does Genesis enable this multi-trading feature as well? 2. In fast markets, it can be very important to quickly cancel or quickly place an order; how would you describe the speed difference between Genesis and IB--from the vantage point of a)the platform and b) lag time for order to arrive at the exchanges.


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BV 206 in the barnyard Elgin, Moray - Aerial Summer skies and sunset over Findhorn Bay and the… Trees silhouetted against the sky at dusk near Ble… Findhorn Village Plum blossom in the orchard The Spey valley from Ordequish Nesting Bluetit The MCR01 at Connel, Oban Ben Nevis - aerial Storm Clouds over the Great Glen The beach and cliffs at Gardenstown Summer Gardenstown Beach Mother and Foal Mare with her Spring foals Helmsdale Lossiemouth Harbour Speybay on the left, Kingston and Garmouth on the… Speybay and the Tugnet Icehouse PortGordon Buckie Harbour Portknockie with Cullen beyond Portsoy Ferness Crook of sheep - it's your turn to dance..… Modesty Frosted leaves by the pond Glasgow - rainy evening 4075712029 o Kibble Palace Glasgow Botanic Gardens at night Kibble Palace at night Up a bit... Guy Fawkes out for a stroll at Kenwood House... IMG 5213 Norwegian Forest Cat Norwegian Forest Cat Portrait of a Norwegian Forest Cat Lochindorb at Sunset Dava Moor in Autumn Findhorn Village - the darkness deepens... Findhorn Beach at sunset Tomorrow is another day... The Falkirk Wheel Cheese Heaven Bridge in Glasgow's West End Gently flows the Kelvin Kelvin Weir
Posted on 05/26/2013
Photo taken on March 10, 2007
1/250 • f/4.0 • 38.0 mm •
Canon PowerShot Pro1
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- Location(s): • Bayelsa, South South — Nigeria
- Specialization: • Teaching / Education Services
- Industry: • Education Services
- Application Deadline: December 22, 2017
- Job Type Fulltime
University of Africa is recruiting for fulltime Assistant Lecturer (Biological Sciences).
The University of Africa, Toru-Orua (UAT) is a new institution established by the Bayelsa State Government to be a Public-Private Higher Educational Institution for the production of outstanding quality graduates and renowned faculty members and committed to building partnerships with people, government and industry.
Applications are invited for the position below:
Job Title: Assistant Lecturer – CONUASS 02
Location: Bayelsa
Faculty: Basic and Applied Science
Department: Biological Sciences (Biology, Microbiology)
Not Specified
Bachelor's Degree/HND
Not Specified
- Candidates must possess a Bachelor's degree in any area of the field of study with a minimum of second class and Masters' Degree (with thesis) in such fields of study with at least 60% or 3.5 CGPA on a 5-point scale obtained from a recognised University.
- Publications in reputable journals, attendance at learned conferences and evidence of registration for PhD would be added advantages.
How To Apply:
Interested and qualified candidates should send their Applications and up-to-date CV's by post (see address below), Email: email@example.com
The CV should contain the following information in the order listed below:
- The first half to 3/4 page should contain a summary of your profile
- Full Name (Surname first in capital letters).
- Post Applied for.
- Date and place of birth (attach birth certificate/sworn affidavit).
- Nationality.
- State of Origin, and Local Government Area (if a Nigerian)
- Contact Details (Home Address, Postal Address/E-mail address(es)/ Mobile Phone Numbers).
- Marital Status.
- Number of Children and their Ages.
- Next of Kin
- Contact Details of next of Kin (Home Address, Postal Address/E-mail address(es)/ Mobile Phone Numbers).
- Institutions attended with dates.
- Academic/Professional qualifications and distinctions obtained with dates (attach copies of credentials).
- Work Experience with dates.
- Present Employment, Status and Salary (if any).
- Research interests and activities
- Conference/courses attended (state titles of papers presented if any).
- Professional accomplishment
- Publications with date.
- Service to national and international bodies.
- Extra-Curricular Activities.
- Any physical challenge?
- Names and address of three (3) referees who must have been closely associated with candidate's academic/work experience.
All candidates are advised to request their referees (3) to forward confidential reports on them directly to the Registrar. The reports should be duly marked "CONFIDENTIAL". If sent by post, envelopes should be marked at the back top left hand corner with: name of applicant, department and position of the application to:
The Registrar,
University of Africa,
Bayelsa State Old Secretariat Complex,
Liaison Office, Rooms 237-242,
Melford Okilo Expressway,
Bayelsa State.


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AmericanVaper is offering 25% off selected eLiquids for the next month. Select from a range of Mt. Baker Vapor or AmericanVaper juices. Most products ship same or next day.
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Category: USA Supplier
Tags: 25% Off, americanvaper, Discount, e-liquid, eLiquid, mt. baker vapor
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Welcome to Embrilliance
Hello, I'm Brian Bailie. Welcome to Embrilliance!
Embrilliance makes embroidery software Fun and Easy.
We run on Windows and Mac OSX.
You are smart and creative. YOU CAN DO THIS! Enjoy reasonable pricing on embroidery software you'll actually Love to Use! We guarantee it can do what you need with a 90 day refund policy if you buy it in our online store.
If you're new to embroidery, or just want to see your designs, check out our world-famous Embrilliance Thumbnailer! At $44.95 it may be the best deal in the embroidery world.
While you're here, check out Embrilliance Essentials! At $149 it does more than programs costing thousands of dollars. But it is priceless because you will love it. This program has become incredibly popular and we thank our growing worldwide community of Embrilliant embroiderers!
Looking for more? AlphaTricks, Density Repair Kit and Enthusiast will help you kick it up a notch!
Ready to create your own designs? StitchArtist is here in three levels! Get your copy today.
Have a Mac and a machine that uses embroidery cards? Our FREE Emboxer program will read and write those cards on a Vikant Ultimate Box. Yes. Free.
Please join us in the Forum for free embroidery designs, FAQs and more. When you're ready to buy, please use our secure online shop.
Happy Stitching!
PS: We're proudly made in the USA but are friends with our distributors and customers worldwide.


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SiteGround is a world leader in web hosting market that provides innovative and secure solutions specialized for hosting all popular open source applications with high quality and well established hosting services. They served globally and amassed around 450,000 domain names throughout United States, Europe, and even Asia, with data centers facilities. They offer a range of hosting solutions ranging from shared Linux hosting to Cloud and Dedicated server solutions for large, growing websites.
You can check Siteground Reviews, User Rating and Complaints here
1. Security
2. Support to CMSs
3. Technical Support
4. Backups
1. Security
SiteGround provides numerous security options, which include the add-on HackAlert Monitor (they charge $1 per month for this) to make you alert about the attack on your website, antispam tools SpamAssassin and SpamExperts, hotlink protection, and IP address blocklists. SiteGround also features an attractive option called Leech Protect, which allows administrators prevent users from giving out or publicly posting their passwords. To avail this service you need to sign up for the Grow plan to get an SSL certificate. Also, SiteGround integrates with CloudFlare for better performance and security services. By using it, a site owner can easily sign up with CloudFlare. SiteCheck is a tool for small businesses, which is also available with SiteGround. This automatic software scanning tool checks your website to see if there is any malware in the code or on the site.
Also Read:
Why Ipage in 1st place of Top 10 Listing, Pros and Cons?
Why Hostingraja in 2nd place of Top 10 Listing, Pros and Cons?
Why InMotion in 3rd place of Top 10 Listing, Pros and Cons?
2. Support to CMSs
They have a great focus on the most popular Content Management Systems like WordPress and Joomla. They don't upsell any forged WordPress features, but instead, they have built-in features drive to achieve better performance for both WordPress and Joomla. SiteGround has a strong feature set especially if you have more technical requirements.
3. Technical Support
SiteGround's primary focus is on customer and technical services, and which translates into the services many wizards, knowledgebase articles, and tutorials. Customer support is available through live chat, ticket-based system, and 24/7 telephone support.
4. Backups
Concerning the caching and backups, customers have access to SiteGround's default SuperCacher, with a flexible range of options available to meet any and all page load requires an optimum speed. Their custom backup software improves the performance of the technology. Instead, SiteGround clients receive daily backups from a system. They do regular backups, which is a good safety feature especially when your backups fail.
1. Plan Limitations
2. Storage Limitations
1. Plan Limitations
The plan limitations to be a disadvantage in and of themselves. They limit disk space across all their shared plans – instead of databases or domains. In comparison with other web hosts, SiteGround's storage space lacks a bit on the small size. There are undoubtedly good reasons for the limitations. The more data customers store on their shared servers, the more likely it is that they'll experience slow load times and server response times.
2. Storage Limitations
However, people who have huge sites with the content of image/video might have an issue with SiteGround's storage limitations. They range from 10GB at the low end to 30GB at the high end. That might be plenty for most text-based sites.
You can dig out the solution to this particular issue is to make your best guess about how much storage you will need to keep your site going and then see if one of SiteGround's plans can accommodate your storage needs.
- StartUp: 10GB storage (okay for most non-CMS / non-WordPress driven sites)
- GrowBig: 20GB storage (okay for WordPress / Joomla / Drupal driven sites)
- GoGeek: 30GB storage (okay for ecommerce as well as WordPress / Joomla / Drupal driven sites)


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Mail for Exchange
Mail for Exchange is a client application for Nokia Eseries and Nseries that allows you to synchronize your phone with Microsoft Exchange servers. You can synchronize emails, contacts, calendars and tasks. It supports Microsoft ActiveSync protocol that is available in Microsoft Exchange Server 2003 or later...Read more


text:
Coventry University is a diverse and exciting place to work and we share the enthusiasm of our staff and students to be the best at whatever they choose to do. As one of the City's biggest employers, we offer some impressive benefits for our staff and are committed to delivering the very best opportunities. We have a comprehensive training, personal and professional development programme that provides our employees with the skills to enhance their performance in the workplace and grow in their careers. There are pension schemes, a generous holiday allowance and flexible working opportunities as well as lifestyle benefits including childcare vouchers, discounted membership to the £4 million sports and recreation centre and schemes such as Cycle to Work and the CU Car Share initiative.
View current job vacancies.
Access the central point of information for all staff across the University.
Check your assessments, access Solar and get course information.
Coventry University academic teaching year is made up of three 16 week-long teaching blocks. Here you will find information about term dates for both new and returning students as well as study break and end of semester dates for undergraduate and postgraduate students.
As an ambitious and innovative university, our research makes a tangible difference to the way we live. Coventry University is already known for delivering research that makes a significant contribution to a number of global challenges.
Your gateway to the right industry experts to help your business.
Use our dedicated team to access the knowledge, insights and innovative ideas of our academics, researchers and talented students.
As an ambitious and innovative university, our research makes tangible difference to the way we live. Coventry University is already known for delivering research that makes a significant contribution to a number of global challenges. Our research centres focus on a range of real world issues including sustainability, disease prevention and innovative engineering. Our new strategy will build on these successes, strengthen our position as an innovative university and will enable us to apply fresh and original approaches to key research challenges.
In the 2008 Research Assessment Exercise, almost two-thirds of our submitted research was rated as international, internationally excellent, or world-leading standard. We are continuing to build on this success in collaboration with businesses, external funders, students and the wider community. We have entered a range of research to the Research Excellence Framework (REF) 2014, view our set of extremely positive REF results and further information about our submission.
As part of our work during REF2014, our Grand Challenge Initiatives focused our research efforts on seven key global issues which explored the following; Sustainable Agriculture, an Aging Society, Low Carbon Vehicles, Integrated Transport and Logistics, Low Impact Building, Digital Media and Human Security.
You can discover our research in a number of ways; take a look at our people, projects, news or events by browsing through the research directories, explore our different areas of research or read some of our spotlight features to discover our latest cutting edge thinking.
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