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Molecular mechanisms of zebrafish motoneuron development
Hale, Laura Ann, 1978-
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Hale, Laura Ann, 1978-
This dissertation describes research to identify genes involved in specification, patterning and development of zebrafish primary motoneurons. We first examined the spatiotemporal expression patterns of retinoic acid and retinoid X receptor mRNAs to determine whether particular ones might be involved in motoneuron specification or patterning. Retinoic acid and retinoid X receptor mRNAs are expressed at the right time to pattern motoneurons, but the expression patterns did not suggest roles for particular receptors. In contrast, netrin mRNAs are expressed in specific motoneuron intermediate targets and knockdown experiments revealed an important role in development of VaP motoneurons. Two identified motoneurons, CaP and VaP, initially form an equivalence pair. CaPs extend long axons that innervate ventral muscle. VaPs extend short axons that stop at muscle fibers called muscle pioneers; VaPs later typically die. Previous work showed that during extension, CaP axons pause at several intermediate targets, including muscle pioneers, and that both CaP and muscle pioneers are required for VaP formation. We found that mRNAs for different Netrins are expressed in intermediate targets before CaP axon contact: netrin 1a in muscle pioneers, netrin 1b in hypochord, and netrin 2 in ventral somite. We show that Netrins are unnecessary to guide CaP axons but are necessary to prevent VaP axons from extending into ventral muscle. Netrin 1a is necessary to stop VaP axons at muscle pioneers, Netrin 1a and Netrin 2 together are necessary to stop VaP axons near the hypochord, and Netrin 1b appears dispensable for CaP and VaP development. We also identify Deleted in colorectal carcinoma as a Netrin receptor that mediates the ability of Netrin 1a to cause VaP axons to stop at muscle pioneers. Our results suggest Netrins refine axon morphology to ensure final cell-appropriate axon arborization. To learn whether Netrin proteins diffuse away from their sources of synthesis to function at a distance, we are developing Netrin antibodies. If successful, the antibodies will provide the research community at large with a new tool for understanding in vivo Netrin function. This dissertation includes both my previously published and unpublished coauthored material.
- Biology Theses and Dissertations [228]
- Theses and Dissertations [2826]


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One of the most common mistakes most of the users commit after uninstalling software is not cleaning its values from the system registry. Not doing so will create problems in re-installation of the same software again as it would coincide with the old values. Sometimes, software does not uninstall and throws errors when the user attempts to uninstall. At this point, there are a few steps to be followed to uninstall the program.
The regular method to uninstall any program is to go to the control panel and click on the program to uninstall and let it run its course. If the program still does not uninstall, you can run system restore, and choose a restore point. Once the restore point is created, install the program, so that if anything goes wrong, you can restore your system to an earlier time.
In Windows 8, you can search for the program that does not uninstall and click on it to uninstall once it shows up in the search menu. Sometimes, the program that is installed does not get listed in the programs menu of the control panel. In such a case, this is one method to uninstall the program.
On the start screen of Windows 8, all the installed programs are listed. You can right click on any of these programs that you want to uninstall and remove them from the system. If neither of these methods works, reinstall the same program to uninstall them. Applications, like the Microsoft Office suite that come with many inbuilt applications that have system dependencies can be tricky to uninstall. Such suites have their own uninstaller and troubleshooting options for uninstallations of any of the applications within the suite.
There are many tools online that can be installed which remove old and unused programs, and corrupted files of installations. They also remove programs with forced uninstallations option. Programs that take up a lot of space and won't uninstall, a tool called Powershell can be used which uninstalls even the most stubborn applications that won't uninstall through standard procedures.
The most common types of software that are wearisome to uninstall are the antivirus and security software applications. For such applications, you can use an external app like the App Remover and uninstall them.
You can also remove the entries of the uninstalled program from regedit, the registry editor. For this, open the registry editor, and go to the HKey local machine, Software, Microsoft, Windows, Current Version in the left hand panel. Then click on the folder of the application that you want to uninstall. Right click on that folder and delete it.
You can also go to the SAFE MODE and click on the program files listed in the Windows directory, Drive C, and delete that folder listed in the common files. Now click run msconfig and click the option that says BOOT. INI and uncheck the SAFE MODE and reboot your system.

subset: commoncrawl


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2. I am writing, slowly and without ambition: writing to exercise narrative muscles. And considering new projects that will take me to very different places.
3. In 2013 I have triumphed over certain types of fear: I've learned how to ride a motorbike (kinda sorta), been in a helicopter and multiple times in a small plane.
4. There have been beautiful places: I have been surprised by the glories of Western Australia.
|Spot the Fitzroy wallaby
|Broome from above
|In which there were sharks
5. Winston Churchill once said, 'Success is not final, failure is not fatal. It is the courage to continue that counts.'


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Kidney Week Annual Meeting
Follow the Renal & Urology News live coverage of the American Society of Nephrology's Kidney Week (formerly Renal Week) annual meeting through the years.
Latest Kidney Week Coverage
Study Reveals Advantages of Non-Calcareous Phosphate Binders
Use of these agents is associated with a much lower incidence of hypercalcemia compared with the use of calcium carbonate or calcium acetate.
Kidney Cancer Linked to Kidney Stones
Meta-analysis reveals a significantly increased risk of kidney stones only in male patients with kidney cancer.
Calciphylaxis Risk Lower in Cinacalcet Users
Calciphylaxis was 75% less likely to develop in patients who received the drug rather than placebo.
Ferric Citrate Controls Phosphorus, Cuts ESA Use
Over 52 weeks, the drug maintained hemoglobin levels while decreasing IV iron use in dialysis patients with anemia.
Diabetic Nephropathy More Common Than Previously Thought
Researchers in the Netherlands report results from an autopsy study of diabetic nephropathy patients.
Insulin Resistance Linked to High Phosphorus in Maintenance Hemodialysis (MHD) Patients
In adjusted analyses, serum phosphorus levels independently predicted glucose disposal rate.
ESA Use May Lower Risk of Transfusion
Benefit seen among anemia and hemodialysis patients with hemoglobin levels below 10 g/dL.
Higher Phosphorus, Cardiovascular Disease (CVD) Not Linked in Kidney Disease (CKD) Patients
Each 0.5 mg/dL increment in serum phosphorus associated with 58% increased odds of coronary heart failure (CHF).
Post-Op Acute Kidney Injury Not Prevented by Aspirin, Clonidine
Aspirin and clonidine increased the risk of major bleeding and clinically important hypotension in acute kidney injury (AKI).
Earlier Use of ESAs Benefits Non-Dialysis Kidney Disease (CKD) Patients
Renal events are significantly less likely if erythropoiesis-stimulating agents are started at hemoglobin levels below 11 g/dL.
Tight Blood Pressure Control Benefits Some Polycystic Kidney Disease (ADPKD) Patients
Tight blood pressure control slows the rate of increase in total kidney volume and reduces left ventricular index.
Severe Periodontal Disease Ups Kidney Disease (CKD) Risk in African Americans
Periodontal disease is associated with a significant 4.2-fold greater incidence of chronic kidney disease (CKD).
Ferric Citrate Phosphate Binder Cuts Hospitalization Rates
Rates for infection-, gastrointestinal-, and cardiac-related adverse events are lower than with sevelamer carbonate or calcium acetate.
Giving Vitamin B6 Ups Resistance to ESAs
New finding on vitamin B6 is the opposite of what investigators hypothesized on patients with anemia.
Plant-Based Phosphorus Best for Kidney Disease (CKD) Patients
Plant-based diet had the lowest urinary phosphorus excretion, whereas an inorganic-based diet had the highest.
Renal and Urology News Articles
- Roxadustat Effective in Chronic Kidney Disease Patients With Anemia
- Younger Men With High-Grade PCa Less Likely to Die After RP Than RT
- Novel Albuminuria Endpoints May Improve CKD Progression Trials
- Molidustat Promising for Renal Anemia
- Global Demand for Bladder Cancer Treatment Threatens Supply in 2019
- Low Vitamin D Tied to Risk for Renal Hyperfiltration in Healthy Adults
- Novel Albuminuria Endpoints May Improve CKD Progression Trials
- Younger Men With High-Grade PCa Less Likely to Die After RP Than RT
- Overactive Bladder Linked to Prostate Cancer ADT
- Second-Line Antidiabetic Meds May Impact Cardiovascular Risk
Sign Up for Free e-newsletters
- Acute Kidney Injury (AKI)
- Anemia
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetes
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Hemodialysis
- Hyperkalemia
- Hyperphosphatemia
- Hypertension
- Hyperuricemia
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)
- Transplantation


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Biswajit Jha
Team India's obsession with all-rounders for the shorter version of the game is finally over. The selectors seem to have understood that there isn't a quality all-rounder in India at present. So it's better to move ahead and do without them rather carrying some pseudo all-rounders in the team.
Ever since Kapil Dev hung up his boots, India's hunt for a quality all-rounder has been on. A bowling all-rounder to be more precise, who can merit a place in the team purely as a bowler besides being a No. 7 batsman. 18 years have gone-by and the search is still on. There have been experiments after experiments without any concrete results. Kapil's contemporary and bête noir Manoj Prabhakar was the only man who carried his legacy for a brief period. There was a time when Prabhakar used to open the bowling as well batting for India. After his unceremonious exit from cricket during 1996 World Cup, India were left with no choice but to rely on part-timers.
Every time anyone came up with something spectacular with both the bat and the ball, he was immediately on the radar of the selectors. Ajit Agarkar was a man with immense talent. He scored heavily and took plenty of wickets wherever he played - be it for Indian Under-19 team or India-A team. In 1998, after a successful series with India-A against Pakistan-A, he was drafted into the Indian team at a tender age of 21. Agarkar started with a bang, breaking Dennis Lillee's records of fastest 50-wicket in ODIs, and also scoring a 21-ball fifty against Zimbabwe. His initial success gave us hopes and made us believe that here was a man who could be the next Kapil.
In between his heroics, Agarkar kept frustrating us. The man from Mumbai hit a century at Lord's and the same man created history for all the wrong reasons by getting out for a duck seven times in a row. His exploits with the ball in Adelaide Test in 2003 helped India win a Test Down Under after a long time. At the same time, he kept on leaking runs at crucial junctures. Meanwhile, we kept pinning our hopes on him and allowed him to become India's highest wicket-taker! For some people he never delivered. Some like to believe that he is still not a finished article! But if we go by pure statistics, he is the next best all-rounder after Kapil.
At a time when the lack of quality all-rounders gave birth to a number of bits and pieces cricketers in ODIs, Robin Singh, who made his ODI debut seven years ago, re-emerged in 1996 at the age of 33 and filled up the all-rounder's slot for the next five years.
At the beginning of 2000 Indian selectors were searching a replacement for the ageing Robin Singh. They finally zeroed in on Reetinder Singh Sodhi, who had just helped India, along with Yuvraj Singh and Mohammad Kaif, win the Under-19 World Cup. He was also in the same mould of Robin- an excellent fielder, a medium pacer and a lower-order batsman. He did well with the bat initially as he scored two fifties but his bowling lacked penetration. After 18 ODIs, Sodhi was jettisoned for good.
Though his military medium pace bowling hardly won India matches, he, along with Ajay Jadeja, Sourav Ganguly and Sachin Tendulkar, often did the job of fifth bowler to perfection. Technically not very sound, he was a gutsy customer when comes to batting. Coming at No. 6 or 7, he was India's rescuer. There were numerous matches when he pulled India out of the woods and gave some incredible victories. But his real contribution came as a point fielder where he used to save so many runs and pull off some incredible catches.
India's hunt for an all-rounder never died down. One century in Wills Trophy semi-final against Delhi saw Bengal seam bowler Laxmi Ratan Shukla achieving the stature of the next Kapil. At a time when Indian selectors were trying hard to find some all-rounders for the 1999 World Cup in England, Shukla came as a 'perfect man' to raise the hopes of many. The three ODIs he played for the country, Shukla neither delivered with the ball nor with the bat. He last played for India in 1999 and never came into reckoning again.
India tried several all-rounders at that time; most of them were spin all-rounders, a species abundant in India. Orissa's Sanjay Raul, Uttar Pradesh's Gyanendra Pandey, Karnataka's Vijay Bharadwaj, Maharashtra`s Hrishikesh Kanitkar- all came into the limelight on the back of superb all round shows at first class level with nobody ever cementing his place in the team.
Then came Sourav Ganguly whose obsession for pace brought up some fast-bowling all-rounders. Railways duo of Sanjay Bangar and Jai Prakash Yadav did enough both with the ball and the bat to attract Ganguly's attention. Their talent, however, could not live up to the expectations of international cricket and they proved to be flashes in the pan.
Ganguly, an astute man, quickly understood that the plight of all-rounders in India. He changed his tactics and tried to compete with the best in ODIs without a single all-rounder. India needed a wicket-keeper who could be a proper middle-order batsman. This was before MS Dhoni came into the picture. Meanwhile, Rahul Dravid, already an established and a respected Test batsman, was finding it hard to cope with the fast-paced limited-overs version of the game. Sourav convinced part-time wicket-keeper Dravid to don the wicket-keeper's role for India. Once Dravid was ready, India looked a strong batting unit with seven top-class batsmen and a quality batsman at No. 7. With four bowlers at his disposal, Ganguly needed to complete the remaining 10 overs with the help of part-timers like Sachin Tendulkar, Yuvraj Singh, Virender Sehwag and himself. Sometimes the strategy backfired, but India had one of the most successful times in ODI cricket including the victory in Natwest Trophy in England and the World final appearance in 2003 during that period.
There were some attempts to turn some specialist players into all-rounders which in most cases turned to be a catastrophe. Irfan Pathan, a fine left-arm swing bowler, forgot his main art when Greg Chappell tried to project him as an all-rounder. After Irfan lost his direction, his elder brother was chosen in the hope of filling the elusive all-rounder's role in the team. The elder Pathan played some blistering knocks including one century against New Zealand, but never looked convincing as an off-spinner. So when he failed with the bat, selectors had no other option but to drop him from the side.
Yusuf Pathan's loss was left-arm spinner Ravindra Jadeja's gain. Jadeja, a member of India's successful Under-19 World Cup campaign, had a successful IPL in 2008. His captain at Rajasthan Royals, the redoubtable Shane Warne hailed him as next big thing. Jadeja's case was opposite to that of Pathan senior. Jadeja bowled reasonably well but his inability to play big shots made him a liability in the team. Jadeja did get a longer run thanks to his proximity to captain Dhoni. But his continuous failure with the ball compelled the selectors to drop him before the World Cup and Yusuf Pathan was back.
After the World Cup his step-brother Irfan Pathan made a came-back in a new avatar. He was again given a lifeline to resurrect his career during India's home series against West Indies and India`s tour of Australia. A shadow of his earlier self, a wiser and more experienced Irfan wanted to be seen as all-rounder. But Dhoni had other ideas. He kept faith in Jadeja. Irfan was purely played as a bowler, a role which he himself was not confident of. The selectors selected all three for the Asia Cup. After everybody failed, they had no other option but to end an era of all-rounders after Kapil Dev.
The hunt for all-rounders, however, did us some good. We might have failed to get an all-rounder, but instead got two world class batsmen - Sourav Ganguly and Virender Sehwag.


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UrbanPromise Wilmington UrbanPromise Wilmington
Here's a sample of our volunteer opportunities:VIEW AS
Mission Statement
The mission of UrbanPromise Wilmington is to equip children and young adults through Christ with the skills necessary for academic achievement, life management, personal growth and servant leadership.
UrbanPromise is now in our second decade of service in Wilmington. Youth in our programs are graduating high school and entering college at unprecedented rates. The retention, attendance, and growth of our programs are strong. Sharing life in Christ has transformed a large, diverse, and growing corps of volunteers, organizations, businesses, schools, neighbors and families.
1994: Rob Prestovwitz volunteers with UrbanPromise Camden to help their struggling microbusiness
1998: UrbanPromise opens its first site, Camp Vicotry, on the East Side of Wilmington
1999: Staff house is purchased on the East Side; Camp Freedom is added on the North Side
2001: Camp Promise (West Side) becomes UP's third program site
2002: Urban Promise School is founded and begins with K4 and K5 classes
2005: Urban Promise School moves to 2401 Thatcher St.
2006: Thatcher St. Headquarters purchased
2007: Work Group initiative begins; Camp Harmony (Middle School) established
2007: West Side site and staff house and purchased; Camp Hope (Southbridge) launched
2009: James Whitely becomes the first StreetLeader to graduate from college
2010: Urban Promise Academy high school holds first classes; UrbanTrekkers launched
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text: mines still acting up. i cant get any data after 9/26 when i started it up this morning and i still cant save my layout when i exit. it still brings up my old layout. anyone else still having issues? i know on friday it was acting wacky with freezes.


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This article is a collaboration between MedPage Today® and:
SAN DIEGO -- Combining a new brush technology with traditional biopsy increased the detection of high-grade dysplasia and/or early esophageal adenocarcinoma in patients with Barrett's esophagus, researchers reported here.
While traditional 4-quadrant forceps biopsy found seven of these lesions, the addition of wide area transepithelial sampling (WATS) detected 23 of these lesions, reported Prashanth Vennalaganti, MD, of the University of Kansas Medical Center in Kansas City, and colleagues at the annual Digestive Disease Week.
"I would expect the use of WATS to become the standard of care for patients at risk of esophageal cancer," Vennalaganti told MedPage Today. "Fortunately we have a pre-malignant condition, Barrett's esophagus, for which we have evidence that it progresses cancer. Unfortunately, we have few good techniques that can identify the stages that it can progress through."
He said use of established biopsy protocols to detect high-grade dysplasia or early-stage cancer can be inefficient, and sometimes doctors fail to adhere to the standard protocol that, in the case of a 10-cm Barrett's lesion, could involve taking 20 to 40 samples. As a result, a vast majority of Barrett's lesions are not sampled, he added.
By supplementing the standard biopsy protocol with WATS, which utilizes a brush that scrapes up tissue that is then processed by a computer, more suspicious lesions can be identified, he said.
But he cautioned that WATS is intended to supplement, not replace, standard biopsy protocols.
"We lumped high grade dysplasia and early-stage esophageal cancer together because we treat both conditions the same way, with endoscopic ablative procedures," he said.
In the study, 160 patients from 16 U.S. institutions were enrolled. All had a diagnosis of Barrett's esophagus and underwent the standard biopsy and WATS. The mean patient age was 63.4, and 76% were male while 95% were Caucasian. The mean Barrett's esophagus circumferential extent was 4.7 cm and the mean maximal extent was 7.1 cm.
The WATS protocol consisted of one kit (two brushes) for each 5 cm of Barrett's esophagus length.
The diagnostic yield for forceps biopsy was high-grade dysplasia/cancer (4.4%), low-grade dysplasia/indefinite for dysplasia (17.5%), non-dysplastic Barrett's esophagus (66.25%), and no Barrett's esophagus (11.9%).
Using WATS in addition to forceps biopsy, an additional 23 cases high-grade dysplasia/cancer were identified for an absolute increase of 14.4% (95% CI 7.5-21.2% and a relative increase of 428%.
One high-grade dysplasia/cancer patient diagnosed by forceps biopsy was misclassifed by WATS as low-grade disease.
The authors concluded that "the use of WATS can improve surveillance programs in patients with Barrett's esophagus."
The ability to detect dysplasia in Barrett's esophagus needs to be optimized, pointed out Philip Katz, MD, of the Albert Einstein Medical Center in Philadelphia, who was not involved in the study.
"Our biopsies have met the test of time and are the standard to which we compare everything to," he said. "What [WATS] seems to do is to allow us to add to our ability to detect [dysplasia in Barrett's esophagus]. The way it has been designed, and the computerized analysis seems, based on the data, to offer an ability to enhance detection."
While WATS did add procedure time, it would be time "well spent," if the data hold up over the long-term, he stated.
"Like everything we do, we will learn more about it, as we use it more and it will find its appropriate place "Right now, I'm using it as an adjunct to my traditional endoscopic intervention for detection of dysplasia in patients with Barrett's."
The study was supported by CDx Diagnostics.
Vennalaganti disclosed no other relevant relationships with industry.
Katz disclosed no relevant relationships with industry.
- Reviewed by F. Perry Wilson, MD, MSCE Assistant Professor, Section of Nephrology, Yale School of Medicine and Dorothy Caputo, MA, BSN, RN, Nurse Planner
last updated
Primary Source
Digestive Disease WeekSource Reference: Vennalaganti P, et al "Increased detection of barrett's esophagus-associated neoplasia using wide area transepithelial sampling in conjunction with 4-quadrant forceps biopsies: final results from a multi-center, prospective, randomized trial" DDW 2016; Abstract 60.


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When the tumor necrosis factor (TNF) inhibitors came on the scene in the late 1990s as a treatment for rheumatoid arthritis, the biologic revolution began, and a formerly crippling disease was transformed into one with a treatment goal of sustained remission. The TNF inhibitors were followed by multiple other biologics that target various inflammatory pathways, with modes of administration ranging from intravenous infusions and subcutaneous injections to oral tablets.
The successes seen in rheumatoid arthritis were then followed by use of these medications in other conditions including inflammatory bowel disease, psoriasis, and psoriatic arthritis. And more recently, "the field of ankylosing spondylitis [AS] management has suddenly come alive," Atul Deodhar, MD, of Oregon Health & Science University in Portland, told MedPage Today in an interview.
For instance, earlier this year the interleukin 17A inhibitor secukinumab (Cosentyx) was approved for use in AS, while trials also are exploring the possibility of targeting the IL-12/23 pathways with ustekinumab (Stelara) and also the JAK-STAT pathway, with agents such as the JAK 1/3 inhibitor tofacitinib (Xeljanz).
Tofacitinib in Phase II
At this year's annual meeting of the European League Against Rheumatism, Desiree van der Heijde, MD, PhD, of the University of Leiden in the Netherlands, presented the results of a phase II dose-ranging study of tofacitinib in AS. The trial included 207 patients who were randomized to receive placebo or tofacitinib in dosages of 2, 5, or 10 mg twice daily for 12 weeks, with follow-up continuing to week 16. More than two-thirds of the patients were men, mean age was 42, and mean disease duration was 6.3 years. The mean Bath AS Disease Activity Index at baseline was 6.7.
The primary endpoint of a 20% improvement in the Assessment of Spondyloarthritis International Society (ASAS20) response criteria at week 12 was met by 40.1% of the placebo group, 56% of the tofacitinib 2-mg group, 63% of the 5-mg group, and 67.4% of the 10-mg group. The increased rates compared with placebo were 15.8% (95% CI 11.1-19.9), 22.9% (95% CI 17.8-28), and 27.3% (95% CI 21.8-33).
Benefits also were seen on secondary endpoints. For instance, the ASAS40 response rates were 19.6% in the placebo group, 42.3% in the 2-mg group (P<0.05), 46.2% in the 5-mg group (P<0.01), and 38.5% in the 10-mg group (P<0.01).
The changes from baseline on the AS Disease Activity Score in the 2-, 5-, and 10-mg groups were -1.2 (P<0.01), -1.4 (P<0.001), and -1.4 (P<0.001), respectively, compared with -0.7 in the placebo group.
On the Bath AS Functional Index (BASFI), the changes from baseline in the 2-, 5-, and 10-mg groups were -1.9, -2.4, and -2.2, respectively, which was a statistically significant difference from placebo in the two higher-dose groups (P<0.05).
Imaging findings also showed benefits. On the Spondyloarthritis Research Consortium of Canada scores, significant changes were seen on MRI of the sacroiliac joints for the 5-mg and 10-mg groups (-3.2 and -3.6, P<0.05 for both) and also for MRI of the spine (-5.5 and -6.6, P<0.001 for both).
"The changes on MRI were quite impressive and comparable to what we've seen with TNF inhibitors," said Walter Maksymowych, MD, of the University of Alberta in Edmonton, who participated in the study. "Our past experience has shown that a good MRI response usually indicates that there's going to be a good clinical response. They don't always correlate, but it's usually an indication that the therapeutic strategy is going to work," he said in an interview.
No AS-specific safety concerns were noted in the study, although "in the 16-week time frame there really wasn't any opportunity to seriously explore adverse events," Maksymowych said. "It seems to be a well tolerated agent in both rheumatoid arthritis and psoriatic arthritis," he said.
The Outlook
Tofacitinib inhibits signaling mechanisms in the cell that are relevant to inflammation, Maksymowych explained. "We do not fully understand which signaling mechanisms may be particularly important in spondylitis. That's still an area of investigation," he said.
As to efficacy, "It's early days yet," he said. "When we look at some of the major clinical response measures, like ASAS40 and BASFI, it's actually fairly comparable to the TNF inhibitors. So I'd have to say it looks like a promising approach, because it's an oral drug, and we don't have a lot of options for the use of oral agents in this condition," he said.
The JAK pathway should be explored further, he stated. "There's still very much an unmet need in spondylitis because only about 50% of patients have major clinical responses. It affects young people, and is a common disease, but we don't have disease-modifying therapies that can prevent the progression of the ankylosis," Maksymowych said.
"So there are still a lot of major challenges in this condition that have been overcome in conditions like rheumatoid arthritis and to some degree in psoriatic arthritis," he said.
However, the unmet needs in AS may persist. "I believe Pfizer will not pursue the indication," predicted John J. Cush, MD, of Baylor University Medical Center in Dallas.
"This is largely because of disappointing results and crowded competition. They also are having trouble getting approval for psoriasis. If they can't get psoriasis and psoriatic arthritis approval, then AS isn't worth it -- not in this era of IL-17 drugs, IL-12/23, and IL-23 looming," Cush told MedPage Today.
The study was sponsored by Pfizer.
van der Heijde reported financial relationships with Pfizer, AbbVie, Amgen, AstraZeneca, Augurex, BMS, Boehringer Ingelheim, Celgene, Centocor, Chugai, Covagen, Daiichi, Eli Lilly, Galapagos, GSK, Janssen Biologics, Merck, Novartis, Novo-Nordisk, Otsuka, Roche, Sanofi-Aventis, UCB, Vertex, and Imaging Rheumatology.
Maksymowych reported relationships with Pfizer, AbbVie, Janssen, Amgen, Merck, Eli Lilly, Celgene, Sanofi-Aventis, Boehringer Ingelheim, and Novartis.
- Reviewed by Henry A. Solomon, MD, FACP, FACC Clinical Associate Professor, Weill Cornell Medical College and Dorothy Caputo, MA, BSN, RN, Nurse Planner
last updated
Primary Source
European League Against RheumatismSource Reference: van der Heijde D, et al "Tofacitinib in patients with ankylosing spondylitis: a phase 2, 16-week, randomized, placebo-controlled, dose-ranging study" EULAR 2016; Abstract OP0002.


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Search Toronto, ON
Pet Sitter in Toronto
Are you going away for the Holidays and looking for somebody who is trained and professional to care for your reptile, small mammal or dog? I have looked after and cared for several dogs spanning the last 10 years, and my girlfriend has certificates in Pet First Aid and is currently undergoing certification for Pet Care 101. I have a husky/shepherd/collie mix here (about 50 pounds) named Grishnackh, several ball pythons, rat colonies, and a Savannah Monitor. Dogs get walked every 4 hours from 9 am to 12 pm, and reptiles get whatever care and feedings they require. I have a spare tank and heat lamp or two here, so you bringing your own might not be necessary. E-mail 647-217-.... Phone can't accept calls right now unfortunately, so text is preferred method. (Unfortunately we cannot take cats, they tend to make my dog quite anxious) SIDE NOTE! If you are looking for your dog to be boarded over the Christmas holidays you must act soon, I have only 6 spots for dogs available at any given time and 4 are already taken up. Act soon and a deal can be struck! ***THIS IS A CAGE-FREE HOME***or text Olivia & Kurtis for a faster response at
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Ethan Hawke is all set to electrify audiences in his upcoming film!
The Hollywood Reporter claims that the American actor will be playing the role of Nikola Tesla in biopic.
The film will "chronicle the life and times of the famed Serbia-born inventor, including his creation of the AC motor and his fierce rivalry with Thomas Edison," the publication reported.
Hawke will be reuniting with the film's writer-director Michael Almereyda. The two worked together on Hamlet and Cymbeline.


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Within Darkness, There Is Always Light
Sometimes, we are in so much pain we forget that within that spiral of darkness, there is light. Sometimes we just need to step beyond our shadow, look at it, and see what it is attempting to tell us, teach us.
The day I took this picture, I was playing with my shadows at a sand dune on a golf course and when I looked at my iPhone and saw the picture, it brought back waves of reflection of the days of youth where I was trapped within this shadow of fear, pain, and deep sorrow and loss.
The biggest "aha" in that moment was remembering that I always chose to find the light, no matter how dark it got.
We are amazingly strong-willed human beings with depths of compassion with inborn, innate love. When we can learn to let go of the situation, thank the situation, and move beyond the situation, an entire new spiral of life begins anew. Remember that no matter what, tomorrow is a new day. Sometimes we get so stuck in a moment we forget that we can, if we choose to, walk away from that moment and move into a new one.
We don't need to live in the past. We do need to move beyond the past with a new sense of self and awareness from the growth we experienced in the process. To regret the darkness is in a sense regretting you were born, for without those experiences you wouldn't be who you are today. To me, each day is a new "Happy Re-Birthday". Each day, no matter what is going on, is a new day to choose how I will either react or embrace and celebrate the new day.
Life is a limitless Kaleidoscope, a playground of sounds, textures, feelings, experiences and perceptions. Our imagination and creativity is the birthing place of all things possible. Be willing to let the drama, hurt, pain of any and all situations go so that you can be open to new paths and choices.
At the end of the day, it is our attitude that will either make us or break us, lift us or drown us. We can either take things as feedback or criticism it is all a matter of perception.
Enjoy the Journey of life and use your experiences to empower, teach, and inspire others. There is always someone, somewhere just waiting to hear exactly at the precise moment what you have to say and share.
How many times have you read a book and went "OMG, I can so relate," etc…. Never take for granted your experiences or wisdom, and never be afraid or embarrassed, because that very thing you withhold could be the very thing that could save somebody else's life.
Another Midnight Production written by: © 2013 Carly Alyssa Thorne


text: NYSE:PSA - Public Storage Stock Price, News, & Analysis Sign in or create an account to add this stock to your watchlist. Get Started $200.46 -2.67 (-1.31 %) (As of 01/22/2019 03:52 PM ET)Previous Close$203.13Today's Range$199.92 - $203.495052-Week Range$180.48 - $234.90Volume757,756 shsAverage Volume801,606 shsMarket Capitalization$34.95 billionP/E Ratio19.60Dividend Yield3.94%Beta0.24 ProfileDiscussionAnalyst RatingsChartDividendEarningsFinancialsInsider TradesInstitutional OwnershipHeadlinesOptions ChainSEC FilingsSocial Media Share on FacebookShare on TwitterShare on LinkedInShare on RedditShare on StocktwitsPrint this articleShare by Email Public Storage, a member of the S&P 500 and FT Global 500, is a REIT that primarily acquires, develops, owns and operates self-storage facilities. The Company's headquarters are located in Glendale, California. At September 30, 2018, we had interests in 2,418 self-storage facilities located in 38 states with approximately 161 million net rentable square feet in the United States and 228 storage facilities located in seven Western European nations with approximately 12 million net rentable square feet operated under the Shurgard brand. We also own a 42% common equity interest in PS Business Parks, Inc. (NYSE:PSB) which owned and operated approximately 28 million rentable square feet of commercial space at September 30, 2018. Receive PSA News and Ratings via Email Sign-up to receive the latest news and ratings for PSA and its competitors with MarketBeat's FREE daily newsletter. Industry, Sector and Symbol Stock Exchange NYSE Industry Real estate investment trusts Sub-IndustrySpecialized REITs SectorFinance Current SymbolNYSE:PSA Previous Symbol CUSIP74460D10 Webwww.publicstorage.com Phone818-244-8080Debt Debt-to-Equity Ratio0.29 Current Ratio1.05 Quick Ratio1.06Price-To-Earnings Trailing P/E Ratio19.60 Forward P/E Ratio19.02 P/E Growth3.94 Sales & Book Value Annual Sales$2.67 billion Price / Sales13.10 Cash Flow$10.7658 per share Price / Cash Flow18.62 Book Value$28.41 per share Price / Book7.06Profitability EPS (Most Recent Fiscal Year)$10.23 Net Income$1.44 billion Net Margins55.38% Return on Equity30.87% Return on Assets14.13%Miscellaneous Employees5,600 Outstanding Shares174,360,000Market Cap$34.95 billion OptionableOptionable Public Storage (NYSE:PSA) Frequently Asked Questions What is Public Storage's stock symbol? Public Storage trades on the New York Stock Exchange (NYSE) under the ticker symbol "PSA." How often does Public Storage pay dividends? What is the dividend yield for Public Storage? Public Storage announced a quarterly dividend on Wednesday, October 31st. Investors of record on Wednesday, December 12th will be given a dividend of $2.00 per share on Thursday, December 27th. This represents a $8.00 annualized dividend and a yield of 3.99%. The ex-dividend date of this dividend is Tuesday, December 11th. View Public Storage's Dividend History. How were Public Storage's earnings last quarter? Public Storage (NYSE:PSA) posted its earnings results on Tuesday, October, 30th. The real estate investment trust reported $1.85 EPS for the quarter, meeting the Zacks' consensus estimate of $1.85. The real estate investment trust earned $706.37 million during the quarter, compared to the consensus estimate of $704.51 million. Public Storage had a return on equity of 30.87% and a net margin of 55.38%. During the same period in the prior year, the firm earned $1.61 EPS. View Public Storage's Earnings History. When is Public Storage's next earnings date? Public Storage is scheduled to release their next quarterly earnings announcement on Tuesday, February 19th 2019. View Earnings Estimates for Public Storage. What price target have analysts set for PSA? 13 brokerages have issued 12 month price targets for Public Storage's stock. Their predictions range from $175.00 to $250.00. On average, they expect Public Storage's stock price to reach $203.5833 in the next year. This suggests a possible upside of 1.6% from the stock's current price. View Analyst Price Targets for Public Storage. What is the consensus analysts' recommendation for Public Storage? 13 Wall Street analysts have issued "buy," "hold," and "sell" ratings for Public Storage in the last year. There are currently 6 sell ratings, 6 hold ratings and 1 buy rating for the stock, resulting in a consensus recommendation of "Hold." View Analyst Ratings for Public Storage. What are Wall Street analysts saying about Public Storage stock? Here are some recent quotes from research analysts about Public Storage stock: 1. According to Zacks Investment Research, "Public Storage is a recognized and established name in the self-storage industry in the United States. Further, the company is benefiting from decent industry fundamentals and expansion efforts. The company's better-than expected third-quarter 2018 core funds from operations (FFO) per share reflected improvement in net operating income (NOI) from same-store and non-same store facilities. Higher realized annual rent per occupied square foot supported the company's same-store performance. However, shares of Public Storage have underperformed the industry it belongs to, in the past three months. Moreover, the trend in estimate revisions of current-quarter FFO per share does not indicate a favorable outlook for the company. Notably, supply has been rising in a number of its markets. This limits its power to raise rents and turn on more discounting. Additionally, rate hike has added to its woes." (11/20/2018) 2. Cantor Fitzgerald analysts commented, "There was slight seq. deceleration in SS revenue growth in 4Q. The company was focused on rents as occupancy declined. The company doesn't provide guidance; our current 2018 SSNOI estimate is 2.0%." (2/21/2018) Has Public Storage been receiving favorable news coverage? Media coverage about PSA stock has trended very positive this week, InfoTrie reports. The research group rates the sentiment of press coverage by analyzing more than six thousand blog and news sources in real-time. The firm ranks coverage of public companies on a scale of negative five to five, with scores closest to five being the most favorable. Public Storage earned a media sentiment score of 3.2 on InfoTrie's scale. They also assigned news headlines about the real estate investment trust a news buzz of 4.0 out of 10, meaning that recent press coverage is somewhat unlikely to have an impact on the company's share price in the next several days. Who are some of Public Storage's key competitors? Some companies that are related to Public Storage include American Tower (AMT), Simon Property Group (SPG), CROWN CASTLE IN/SH SH (CCI), Prologis (PLD), Equinix (EQIX), Welltower (WELL), Equity Residential (EQR), AvalonBay Communities (AVB), DIGITAL RLTY TR/SH (DLR), Ventas (VTR), SBA Communications (SBAC), Realty Income (O), Weyerhaeuser (WY), Boston Properties (BXP) and Essex Property Trust (ESS). Who are Public Storage's key executives? Public Storage's management team includes the folowing people: Mr. Ronald L. Havner Jr., Chairman & CEO (Age 61)Mr. Joseph D. Russell Jr., Pres (Age 59)Mr. Edward John Reyes, Sr. VP & CFO (Age 58)Ms. Lily Yan Hughes, Sr. VP, Chief Legal Officer & Corp. Sec. (Age 56)Mr. B. Wayne Hughes Sr., Founder & Chairman Emeritus (Age 85) Who are Public Storage's major shareholders? Public Storage's stock is owned by a variety of of retail and institutional investors. Top institutional shareholders include State of Alaska Department of Revenue (0.04%), USS Investment Management Ltd (0.03%), Northstar Investment Advisors LLC (0.03%), Nisa Investment Advisors LLC (0.03%), Gulf International Bank UK Ltd (0.02%) and Gofen & Glossberg LLC IL (0.02%). Company insiders that own Public Storage stock include David F Doll, Gary E Pruitt, John Reyes, Lily Yan Hughes, Ronald L Havner, Jr and Ronald P Spogli. View Institutional Ownership Trends for Public Storage. Which major investors are selling Public Storage stock? PSA stock was sold by a variety of institutional investors in the last quarter, including Gulf International Bank UK Ltd, Denali Advisors LLC, Gofen & Glossberg LLC IL, Northstar Investment Advisors LLC, DNB Asset Management AS, Louisiana State Employees Retirement System, Oakbrook Investments LLC and Diligent Investors LLC. Company insiders that have sold Public Storage company stock in the last year include Gary E Pruitt, Lily Yan Hughes and Ronald L Havner, Jr. View Insider Buying and Selling for Public Storage. Which major investors are buying Public Storage stock? PSA stock was bought by a variety of institutional investors in the last quarter, including Nisa Investment Advisors LLC, Weather Gauge Advisory LLC, USS Investment Management Ltd, TrimTabs Asset Management LLC, Ipswich Investment Management Co. Inc., Virtu Financial LLC, RNC Capital Management LLC and Capital Investment Advisors LLC. View Insider Buying and Selling for Public Storage. How do I buy shares of Public Storage? Shares of PSA can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Vanguard Brokerage Services, TD Ameritrade, E*TRADE, Scottrade, Fidelity and Charles Schwab. What is Public Storage's stock price today? One share of PSA stock can currently be purchased for approximately $200.46. How big of a company is Public Storage? Public Storage has a market capitalization of $34.95 billion and generates $2.67 billion in revenue each year. The real estate investment trust earns $1.44 billion in net income (profit) each year or $10.23 on an earnings per share basis. Public Storage employs 5,600 workers across the globe. What is Public Storage's official website? The official website for Public Storage is http://www.publicstorage.com. How can I contact Public Storage? Public Storage's mailing address is 701 WESTERN AVENUE, GLENDALE CA, 91201. The real estate investment trust can be reached via phone at 818-244-8080. MarketBeat Community Rating for Public Storage (NYSE PSA)Community Ranking: 1.7 out of 5 ()Outperform Votes: 321 (Vote Outperform)Underperform Votes: 604 (Vote Underperform)Total Votes: 925MarketBeat's community ratings are surveys of what our community members think about Public Storage and other stocks. Vote "Outperform" if you believe PSA will outperform the S&P 500 over the long term. Vote "Underperform" if you believe PSA will underperform the S&P 500 over the long term. You may vote once every thirty days. This page was last updated on 1/22/2019 by MarketBeat.com StaffFeatured Article: What are the Benefits of Index Funds?


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What do you know about Barack Obama?
It's a fair guesstimate many Hobokenites that plan on voting in the 2008 Presidential Election, are big fans of Barack Obama.
Myself, am still undecided, and completely unhappy with how the whole Primary was run, but that's another story. Additionally, me and my friends also have our opinions about how the national news media "shapes" individuals opinions, but that too, is a discussion for another day.
But deep within my vault of 100's of thousands of emails, I stumbled across this email the other day, and I would like to hear the "COUNTER-POINT" from Barack Obama supporters in Hoboken:
The Truth about Obama?
You Don't Know the Truth About Barack Obama Until You Read This Book
- Has any major presidential candidate received less critical examination than Barack Obama?
- People blindly flock to him, the press fawns over him, but nobody questions his promises, plans, or past—until now.
In The Case Against Barack Obama: The Unlikely Rise and Unexamined Agenda of the Media's Favorite Candidate, investigative journalist and National Review Online political reporter David Freddoso removes the gilt from the golden candidate, exposing Obama for who he really is: the #1 most liberal U.S. senator whose policies and inexperience could put our country in serious jeopardy.
Like any convincing argument, Freddoso supports The Case Against Barack Obama with sound evidence and facts. Delving into Obama's legislative record, interviewing his colleagues, and analyzing Obama's books and speeches, Freddoso does the research that the media has neglected. His conclusion? Obama the Orator is very different from Obama the Legislator. From his history of supporting corrupt Chicago politics to his extreme liberal voting record, The Case Against Barack Obama proves that Obama is not the politician of "change", but the politician of status quo.
In this shocking exposé, Freddoso builds his case by revealing what the nightly news hasn't told you, including:
- Obama's extensive connections to corrupt Chicago politics—while he claims to be a reformer
- Obama's plans to increase taxes—amid rising fuel and food prices, he just voted to raise taxes for anyone making more than $32,000
- Obama's dangerous mix of inexperience and poor judgment—evident in his shifting policy positions and the Rev. Wright scandal
- Obama's radical voting record—he repeatedly voted against legislation to protect babies born alive during failed abortions
No doubt there will be other books about Barack Obama, but The Case Against Barack Obama is the first comprehensive and critical look at the man who would be president. Freddoso builds a rock-solid case against Obama's "bipartisan reformer" façade, going where most journalists—and books—refuse to tread.
Is the book accurate in any way? Or is this just PURE POLITICAL SPIN once again?
I appreciate any and all comments on this, as I want to know how you Obama fans might respond.


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Romanian Muslim Convert Arrested for Bomb Plot
Another day, another arrested Islamic militant.
Florin Lesch, 30, who Romanian authorities said had converted to Islam, stands handcuffed in Timisoara Romania, Tuesday June 27 2006 after being detained for allegedly planned to detonate a car in a public place in the western city of Timisoara, to protest Romania's alliance with the United States in Iraq and Afghanistan, authorities said Tuesday. Police from the organized crime unit blocked his car late Monday about 30 kilometers (20 miles) east of Timisoara while he was driving toward the city. He tried unsuccessfully to escape. (AP Photo / Dragos Bota)
Romania currently has over 800 troops in Iraq.
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Guitar Tutors in Baton Rouge, LA
Find Private & Affordable Guitar Tutoring in the Baton Rouge Area!
Masters in English, PhD Candidate @ Tufts University. English Major undergraduate (GPA 3.57).
Biology Major at Louisiana State University with a minor in Business Administration.
I graduated from Northwestern State University with a Bachelor's in Biology and a Minor in Spanish. My GPA was 3.94.
B.S. Secondary Education: English from LSU
Senior Chemistry Major at LSU
Biological Engineering at LSU
Louisiana State University (LSU), Civil Engineering, Graduate Student
Bachelor of Art Aug 2008 - May 2012 Georgia State University Studio Art Associate of Art Aug 2006 - May 2008 Middle Georgia...
I am currently studying at Southeastern Louisiana University with a major in Nursing. I graduated from Baton Rouge Magnet High School...
I am a sophomore at LSU with at 3.95 GPA, studying industrial engineering. I graduated from Baton Rouge Magnet High School with a 4.5 GPA...
I majored in chemistry with a Phd, LSU. 2013.
Senior Interdisciplinary Studies major with Business, Sociology, and Communication Studies minors at Louisiana State University. 1ST...
Second year Biochemistry major at LSU
WEBC/JSBC, graduated in 1991 with B.S.


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Photoshop Automator Actions v. 5.0.1
Mac OS X's Automator provides a friendly, flowchart-like front end for the incredibly powerful AppleScript capability built into most applications and the Mac OS itself. Ben Long has created a set of 95 Automator Actions that use Photoshop CS4 and CS5 to change images dropped into a folder. (There are also versions for Photoshop CS2–CS3.) The basic collection, which includes 30 actions, is free. The extended collection costs $20. Some of our favorites are:
Contact Sheet
Change Mode
Add Watermark
Flatten Document
Auto Levels
Change Resolution
Reduce Noise
Dust and Scratches
Smart Sharpen
Assign Color Profile
Resize Image
Rename from EXIF
Save as TIFF
Save as JPEG
Copy IPTC to Spotlight
The package also includes sample workflows and a 79-page manual describing the actions and an introduction to using Automator. You can download the actions and read all about them at www.completedigitalphotography.com/?p=339
article and link via Design Tools Monthly


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The Leap Year Letter2.09.2012
You may think I'm a little cheesy.. But that's okay, because I am a cheese-master. I know! Here's what I did....Four years ago (February 2008) I decided to write a letter to Lovey to be opened in 2012. A leap year love letter! I emailed it to myself and it got "buried" in my inbox, and I sort of forgot about it. It wasn't until earlier this month that I remembered that I had written said letter... And I've decided to share it on my blog. But first I have to edit it because it has some names and personal details (nothing bad) that need to be deleted out of respect for the people mentioned (again, nothing bad). Anywho! I think that this leap year you should think about writing one to yourself, or a loved one..Yup..It's a good idea. DO IT!
10 comments
That is such a sweet idea! Has he read it yet? I kinda want to know what he though. Ok, ok...I really wanna know!ReplyDelete
That's such a sweet idea!! Maybe Tim & I can write one to each other to open on our 5th wedding anniversary or something! Thanks for the idea ;)ReplyDelete
What a cute idea :) You are so creative and thoughtful :)ReplyDelete
Fun idea! Has he read it yet?ReplyDelete
what a fun idea! totally want to do this now.ReplyDelete
what a great idea. I wish I would think of things like that. Maybe I'll do it! Thanks for the idea :)ReplyDelete
that is such a cute idea!!ReplyDelete
How cool! I can't wait to read it!ReplyDelete
What a cute idea!!! SO sweet!ReplyDelete
What a great idea you genius of a woman!ReplyDelete
I generally reply by email, unless you are a No-Comment-Reply Blogger.
Thank you for making my day!
Subscribe to: Post Comments (Atom)


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Steel Assault is a 2D platformer for PC, heavily inspired by NES games and utilising many of the same limitations of that 8-bit system such as heavy dithering.
"As technological advances continued into the 2030s, the United States's economic foundations caved in. Peaceful protests devolved into riots and all-out civil war, as people starved in the streets. One man rose to power out of the rubble: General Magnus Pierce, a cruel and ruthless tyrant with delusions of restoring America's former grandeur. You play as a resistance soldier equipped with a powerful robotic suit (one of the last of its kind), dropped into a long-abandoned enemy-occupied Washington, D.C."
Check out the recently launched Kickstarter Campaign, as well as the Official Website and Twitter Feed.
Check out our Indie Game Store
RPG - Visual Novel - Arcade - Puzzle - Adventure - Quiz - Strategy - Sport
RPG - Visual Novel - Arcade - Puzzle - Adventure - Quiz - Strategy - Sport


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Apr 11, 2017
Rüsselsheim. Springtime is convertible time. The Opel Cascada can cruise in the sunshine and if there is an April shower, it can close the fabric roof in only 17 seconds.
The impressive convertible with space for four and their luggage is now available as the Cascada Supreme with subtle design accents from friendly Opel dealers. Every detail and every shade of color has been carefully matched with the other. The convertible for the style-conscious can be ordered in "Lava Red", "Snow White" or "Onyx Black". The black grille crossbeam, the black door mirrors and the 20-inch light-alloy wheels in bi-color design perfectly suit each paintwork. The door and cockpit trim materials are highlighted with red seams, which are matched by the decor strips and the heated three-spoke steering wheel covered in piano lacquer. Typically Opel are the ergonomic AGR seats with electro-pneumatic lumbar support and extendable thigh-support for maximum comfort behind the wheel. In the Cascada Supreme the seats are upholstered with high-quality leather – including the characteristic red seams.
The Opel Cascada is a convertible for everyday driving in all seasons, with a high-quality fabric roof including acoustic damping that keeps out the wind noise when closed. In contrast to many convertibles, Cascada passengers can comfortably chat or listen to Vivaldi's "Four Seasons" even at higher speeds. The roof can be closed at the push of a button even while driving, up to a maximum speed of 50 km/h.
In addition, the Cascada driver benefits from a range of assistance systems: Front Collision Warning, Lane Keep Assist and Side Blind-Spot Alert increase safety; Traffic Sign Recognition, High Beam Assist and Park Assist with parking space detection make life easier. Driver and passengers also enjoy best connections with the Opel OnStar personal connectivity and service assistant, which offers a Wi-Fi hotspot as well as services such as hotel reservations1 and parking location2.
The gasoline engines range from the 1.4 Turbo with 88 kW/120 hp (fuel consumption in New European Driving Cycle: urban 8.7 l/100 km, extra-urban 5.5 l/100 km, combined 6.7 l/100 km, 154 g/km CO2) to the powerful 1.6 Direct Injection Turbo with 147 kW/200 hp (NEDC fuel consumption: urban 8.54 l/100 km, extra-urban 5.8 l/100 km, combined 6.8 l/100 km, 158 g/km CO2). The 1.6 Direct Injection Turbo is also available with a six-speed automatic transmission. The diesel alternative is the frugal 2.0 CDTI with 125 kW/170 hp (NEDC fuel consumption: urban 6.0 l/100 km, extra-urban 4.2 l/100 km, combined 4.9 l/100 km, 129 g/km CO2).
Prices for the Opel Cascada start at €26,900. The Supreme equipment pack is available with the Innovation model upwards for €2,500 Euro (MRP including VAT in Germany).
1 Via Booking.com. E-Mail address and credit card required.
2 Via Parkopedia
Opel will use reasonable efforts to ensure that the contents of this Site are accurate and up to date but does not accept any liability for any claims or losses arising from a reliance upon the contents of the Site. Some of the information on this Site may not be correct due to product changes which may have occurred since it was launched. Some of the equipment described or shown may only be available in certain countries or may be available only at extra cost. Opel reserves the right to change product specifications at any time. For the actual product specifications in your country, please consult your Opel dealer.


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A List of the Ten Most Expensive Super Bowl Rings
|Date & Time
|Thursday May 29, 2014, 12:00 PM (EDT)
|TV Channel
|Stream live sports and ESPN originals on ESPN+ for only $4.99 a month. Start your 7-day free trial today!
I've lived in Ohio for just about half a decade now and I finally made it to the one place I really care about a couple of weeks ago. Yup, you called it, the NFL Hall of Fame. The entire facility is fabulous, but I was especially fascinated by their full collection of Super Bowl rings. So…much…bling, y'all. This got me thinking about which rings have the highest value today, so we're going to break it down in today's top ten list. Keep in mind that these are ranked by current worth, not manufacturing price.
1. The Super Bowl XXV ring belonging to one famed New York Giants player (does the name Lawrence Taylor ring a bell?) hit the market at $230,000. This is far more than any other NFL championship ring has fetched. Bear in mind that the player the ring belonged to can dictate market value as you continue reading through this list.
2. Super Bowl I belonged to the Green Bay Packers (and we wonder why it's called the Lombardi trophy). This ring is now worth a cool $100,000. It isn't nearly as elaborate as modern rings, featuring just one center diamond, but you really can't put a dollar amount on the history behind this one.
3. The 2004 New England Patriots beat the Eagles by a field goal to win Super Bowl XXXIX. The white gold and diamond ring celebrating this win is one of the heaviest on this list, weighing it at 100 grams. It is currently valued at $65,000.
4. The Colts won Indianapolis's first Super Bowl in 2006. Their Super Bowl XLI ring is worth $60,000 and features pave diamonds, a diamond Lombardi trophy, and a sapphire horseshoe on the face. The side displays the score of the game and the word "Faith."
5. The New England Patriots won Super Bowl XXXVIII by a field goal. It became the first of their back-to-back Super Bowl victories. This game's ring, valued at $58,000, showcases the team's 15 straight victories on the side. It's face has two diamond Lombardi trophies and a sapphire, diamond, and ruby Patriots logo.
6. Super Bowl XLII, won by the New York Giants, was also decided by a field goal. The white gold ring from this contest is valued at $50,000. It has a pave diamond face with three raised Lombardi trophies and the Giants' logo, also encrusted with diamonds.
7. The 1985 Chicago Bears' Super Bowl XX ring is worth $45,500 on the modern market. This ring features 40 diamonds on the face, some of which are arranged to depict the team's logo. The side showcases the score of the game, the NFC logo, and the Lombardi trophy.
8. No surprise that the '72 Miami Dolphins' ring is on this list (though I was honestly shocked it didn't come in with a higher ranking). The side of this ring celebrates both the team's undefeated season and Super Bowl VII win. The face features a single diamond surrounded by smaller precious gems. It's valued at $45,000.
9. The Dallas Cowboys won Super Bowl XXX, their 5th championship, against the Pittsburgh Steelers. The ring from this match-up is worth $41,000 nowadays. It has diamonds in the shape of a star on the face and depictions of 5 Lombardi trophies on the side.
10. The 1987 Washington Redskins' Super Bowl XXII ring is worth $40,000 today. The ring is 10k gold and features diamonds and rubies in the shape of the Lombardi trophy and a football. Not half bad that selling the least valuable ring on this list could still buy you a Corvette.


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"FROM PAN PIPES TO THE NAI:This album came from a boot sale a few months ago. Now, please forgive my ignorance, but I had always associated the pan pipe with the music of the Andes, so this came as a bit of a revalation. I thought the record might provide some momentary amusement, but actually it is a highly energetic gypsy romp - the music is spectacularly good. There are some beautiful moments in which Nicu plays his pipes to emulate bird calls, and his playing is brilliant throughout, however the real star of this album is, for me, the fantastic Cimbaal player - Ion Miu, who's playing on the zither like Cimbalom is just gorgeous.
Legend has it that the God Pan made the first Pan Pipes from reeds, to play to his loved one, the nymph Syrinx.
The instrument originally had 5 to 7 reeds but many variations were made in stone, porcelain, bronze, etc. It was a folk instrument played mostly by farmers, shepherds and gypsies, and has remained an instrument of the country people, especially in Roumania.
In the 18th Century, the Roumanians developed it with the introduction of bamboo pipes, and extended it to as many as 23 pipes. At this time, with the increase in size, its form changed from flat to curved for ease of playing and to extend the playing technique, and it became known as Nai..."
01 Ciocirlia (The Lark)
02 Coboara Neica Calare
03 Doina De La Titu
04 Sirba de Concert
05 Busoic de la Plenita
06 Ca Pe Giu
07 Sirba Din Muntenia
08 Hora Staccato
09 Munte, Munte, Brad Frumos
10 Hora Lunga
11 Jocul Oilor Din Maramures
12 Miorita
13 Coragheasca
Get it HERE.


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Magazine article Diverse Issues in Higher Education
A Passion from the Philippines: Dr. Ethel Nicdao Looks at Health Disparities in Asian-American Communities
Article excerpt
Dr. Ethel Nicdao was a late bloomer when it came to choosing her field. In her junior year at the University of California, Davis, she took a seminar taught by Dr. Debora Paterniti, who was on Nicdao's dissertation committee at the University of New Mexico years later.
"It exposed me to this very exciting field that I honestly didn't know existed. I didn't realize there were other ways to look at medicine and health," says Nicdao, an associate professor at the University of the Pacific in Stockton.
Her work in medical sociology includes the study of health disparities, mental health, physician and patient interactions, access and delivery of health care services, quality of care and chronic illness. Her research explores low-income rural communities and focuses on Asian-Americans, who researchers say are insufficiently studied by the social sciences.
Her research is connected to her "lived experience," says Nicdao, whose family immigrated to San Francisco from the Philippines when she was 8 years old.
Whether it is breast cancer among Asian-American women or exploring how culture, religion and language affect responses to diseases among the Hmong in California's Central Valley, much of Nicdao's work focuses on examining the differences among the diverse Asian-American population. "We have a tendency to lump all subgroups into one umbrella. We ignore the differences. We don't disaggregate the data," says Nicdao, who is also an associate fellow at the University of New Mexico's Center for Health Policy.
For example, she notes that Asian-American women in general have the lowest death rates from breast cancer. Yet, breast cancer is the leading cause of death among Filipino women, and Japanese-American women have the highest breast cancer rate among Asian-American women. By grouping all Asian-American women together, the differences within the group are overlooked, says Nicdao, who sought treatment for breast cancer in 2010.
As a scholar, Nicdao says it is her "obligation and privilege" to work in the community to end social inequality. Her research in the Laotian and Hmong communities in Stockton is a significant part of her work. She has developed partnerships with community-based organizations in the area, connecting her research with their needs. …


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All of my ladies are up in Yorktown, Virginia this whole week. I am taking a week-long class on the Psalms that goes from 8 to 5 and Susan thought it might be best to take the girls and visit family while I can get some sleep and focus on the class before me. This will be the longest I have been away from my daughters and though the sleep has been nice, I already miss my girls. I might write some Lament Psalms of my own before the week is over!
Just to recap the recent events; the week and a half that Susan and I were sick were long and arduous. In so many ways we were just glad to make it through each day. I never realized to what extent lack of sleep could affect a person. There was one night where Susan had Abigail and Evelyn was crying in the other room in her crib. Though I could somewhat make out the cry and at some distant level in my subconscious I knew it was important for me to get up, it took Susan giving me some forceful encouragement for me to fully realize I needed to act. Whether I got up then and came back, or just moved around a bit, I don't remember, but I somehow I ended up with a pillow on my chest, of which I was comforting like it was my sweet little Evelyn. Meanwhile my real child was still upset in the other room. Susan had to make me aware that I was not in fact holding our child but a pillow.
I hear they use sleep deprivation as a tool of interrogation and torture.
By the grace of the LORD we all got better without getting the girls sick. We are so thankful for all the prayers. Susan's mom came and stayed with our family and was such a huge blessing. I couldn't imagine making it through the week as well as we did without her or our blessed small group.
To be honest, it is hard to see out of the fog of little sleep and energy, so hearing the struggles and victories of others is always a welcomed perspective and encouragement. I want us continually to remember the Kingdom of Christ in the midst of this season so that in our struggles we can begin and end our prayers with thankfulness as well as the hope that we are faithfully serving the LORD during this time.
Grace and Peace.


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Relationship Details
Celebrity Biographies
Ryan O'Neal hooked up with Melanie Griffith in 1975. Ryan O'Neal is currently available.
Entertainment - Actor
Why Famous: Love Story
Age: 77 (b. 4/20/1941)
Entertainment - Actress
Why Famous: Working Girl; daughter of Tippi Hedren and the wife of actor Antonio Banderas
Age: 61 (b. 8/9/1957)
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Boyer responds to Globe inaccuracies, urges inclusion of GA views
In a letter sent today to the editors of The Boston Globe, AOPA President Phil Boyer expressed his shock over the newspaper's unbalanced and irresponsible reporting on the supposed terrorism threat posed by general aviation.
"It is irresponsible to imply that nothing has been done to safeguard general aviation. That is far from the truth," Boyer wrote, pointing out the numerous GA security programs that have been put in place since September 11, 2001.
An August 26 article headlined "Analysts warn of small-plane terrorism threat" used a yet-to-be-released study by the Center for Strategic and International Studies (CSIS) as the source for claims that GA presents an immediate threat to the safety of the nation. But even CSIS has denounced the Globe's article as "incorrect" and "incomplete."
"If your writers want to provide fair and accurate coverage on general aviation, consider the world's largest aviation organization as a resource," Boyer wrote. "Don't ignore us next time an issue develops."
General aviation got its say before a broad audience today when AOPA President Phil Boyer responded to recent media reports claiming that GA is a terrorist threat. During a morning drive-time interview on WTOP radio, Washington, D.C.'s top-rated news station, Boyer defended security measures already in place for general aviation [broadband connection recommended]. Shortly after that interview, the Center for Strategic and International Studies (CSIS), author of a not-yet-released study cited in a Thursday article in The Boston Globe headlined "Analysts warn of small-plane terrorism threat," denounced the article as "incorrect."
During the interview, WTOP reporters asked Boyer about a scenario outlined in the Globe suggesting that terrorists could use a small airplane to attack major sports stadiums like Washington's FedEx Field. Boyer pointed out that airspace restrictions already prevent small aircraft from flying over stadiums nationwide, and that in Washington, D.C., an additional 15-mile no-fly zone and other restrictions make the nation's capital one of the safest places in terms of aviation activity - a point the reporters seemed to find comforting.
"It's a tough time and any little bit of reassurance is always welcome," the WTOP host responded.
Boyer also reminded the public that most GA aircraft are operated in much the same way as other forms of personal transportation, like cars.
"There's the general aviation airplane in which the pilot and the passengers know each other," Boyer said. "That's the norm." He added that the security measures imposed on commercial airlines and charter operations don't make sense for small airplanes used for personal transportation.
Boyer also noted that following the events of September 11, 2001, AOPA and the GA community began to immediately address security issues. Today, GA is still actively working to improve its own security with new national guidelines for airport security, photo identification for pilots, and programs like AOPA's Airport Watch that use the people who know GA best - pilots and airport businesses - to watch for and report suspicious activity.
Boyer's comments followed a week in which supposed general aviation security risks were hyped in the general media. While many of those reports seemed to be sparked by the Globe article, CSIS, author of the study on which the article was based, stated that the organization has not drawn any conclusions about the vulnerability of GA to terrorist attack.
"The Globe article is incomplete and does not take into account a broad range of findings that are still under development," said Jay Farrar, CSIS vice president for external relations.
For more information, see " General Aviation and Homeland Security."
August 27, 2004


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- AstrolutelyRating: 4.63/5 (187 Votes)
- Astrology KingRating: 4.37/5 (143 Votes)
- Sally KirkmanRating: 4.24/5 (146 Votes)
Easily find the best 2016 astrology forecasts and this year's horoscopes for all star signs here. If you find another great one to share please contact us.
If you visit a site, please be sure to return to share your opinion with others. Simply click on the stars for your rating and/or leave a comment below.
Written by experienced Australian/international astrologer Yasmin Boland, who writes for various AUS, NZ, US and UK publications.
One of the few sites that provide daily horoscopes for each global time zone. Instead of working out whether these readings are for today, yesterday or tomorrow, they are sorted for you.
There is an enormous amount of astrology information on this site by author and astrologer Skye Thomas.
The generic monthly and 12 month forecasts are provided free, however if you need a personal reading you can do that too (for a cost). Most horoscope scanners with be more than happy with the generous monthly analysis.
Terry Nazon has been a professional astrologer for over twenty years and has been voted among one of the top 10 astrologers in America and has had her articles and horoscopes published in international magazines such as Cosmopolitan and Glamour.
She is a member a many professional astrology organisations and fellowships and has continuously published an astrology newsletter, Vision Quest, since 1997.
Sally Kirkman has been an astrologer for the past twenty years and as an experienced astrologer her media CV is impressive, featuring in many top British newspapers and magazines. In 2011 Sally began publishing monthly horoscopes online.
Her monthly predictions are very detailed throughout and provide insights relating to specific days in the month. The interpretations are an excellent balance of astrological readings and star sign horoscopes making them easy to understand for the average star sign enthusiast.
Jeff Prince (UK Astrologer) is the predominant astrologer on this site, however it is unclear whether he writes the scopes as he states he has "a variety of new and interesting astrologers".
Daily, weekly and Monthly horoscopes are separated into General, Money, Love and Career.
Formerly a UK astrologer, (now based in Tokyo) John Hayes delivers brief daily, weekly and monthly horoscopes in a simple, easy to understand format with general guidance.
Catering for different timezones with yesterday, today, tomorrow options the daily scopes suitable for a quick glance, but not if you are adter something more substantial.
Jessica Adams is an international pyschic astrologer and author. Currently writing for Cosmopolitan Uk, Harper's Bazaar UK and Australian Women's Weekly. Her personal site shares her weekly and monthly forecasts as well as a look at 12 months ahead.
Every horoscope provides a thorough analysis of each sign as well as an indepth astrological overview of the week.


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NEW YORK, Jan. 12, 2018 (GLOBE NEWSWIRE) -- Jim Miller, Chairman and CEO of ImageWare Systems joined us "In The Boardroom" to discuss recent developments. The entire interview is here: http://securitysolutionswatch.com/Interviews/in_Boardroom_ImageWare.html
On December 22, 2017, ImageWare released the following:
ImageWare® Systems, Inc. (ImageWare or IWS), a leader in mobile and cloud-based, multi-modal biometric identity management solutions, announces the availability of major enhancements to its GoVerifyID® mobile app, GoMobile Interactive® (GMI) cloud platform, and GoVerifyID Enterprise Suite products. These product updates build upon ImageWare's patented, ultra-scalable, and adaptable biometric authentication systems to provide even broader end-to-end solutions.
ImageWare has extended the authentication methods that are available in the GoVerifyID mobile app and GoMobile Interactive cloud service to give users and organizations even more choices, while further increasing convenience, identity assurance, and security. GoVerifyID now provides palm image recognition using the latest FUJITSU Matching Algorithm as an authentication option along with face, voice, and fingerprint recognition. Additionally, ImageWare now offers an optional 6-digit secret PIN as an alternate, non-biometric authentication method.
ImageWare has extended the GoVerifyID integration with enterprise ecosystems for both Microsoft® and IBM® environments. ImageWare introduced a new Credential Provider for GoVerifyID Enterprise Suite for Windows. This provides additional security features for Windows computers, including support for Windows® Biometric Framework compatible devices. GoVerifyID for IBM Security Access Manager (ISAM) was also recently released to provide turnkey integration similar to the end-to-end GoVerifyID solutions for CA®, SAP®, and Aruba® systems.
"As part of our continued commitment to help organizations secure their business and simplify user experience, we have released our newest versions of the GoVerifyID® family of products," said Jim Miller, Chairman and CEO of ImageWare. "By increasing the number of options for biometric and non-biometric authentication methods, ImageWare gives users and organizations the ultimate in choice, flexibility, user assurance, and security."
"Using our new FUJITSU Matching Algorithm for palm image recognition on your mobile phone along with a secret PIN provides the preeminent 'what you have,' 'what you know,' and 'what you are' multi-factor authentication solution. We provide this GoVerifyID technology as part of FUJITSU Biometrics-as-a-Service™," said Jason Bradlee, Head of Security for Americas region, Fujitsu America, Inc. "Our studies have shown that often people prefer to submit an image of their palm rather than taking a selfie, as it is less obtrusive and more private."
More detailed information is available in the GoVerifyID Product Update document: http://info.iwsinc.com/GoVerifyID-Product-Release-Dec-2017
Trademarks: Fujitsu, the Fujitsu logo, PalmSecure, K5, Finplex and "shaping tomorrow with you" are trademarks or registered trademarks of Fujitsu Limited in the United States and other countries. Biometrics-as-a-Service is a trademark or registered trademark of Fujitsu America, Inc. in the United States and other countries. ImageWare, GoVerifyID and GoMobile Interactive are trademarks or registered trademarks of ImageWare Systems, Inc.in the United States and other countries. Microsoft and Windows are trademarks or registered trademarks of Microsoft Corporation in the United States and other countries. IBM is a trademark or registered trademark of IBM Corporation in the United States and other countries. CA is a trademark or registered trademark of CA Technologies in the United States and other countries. SAP is a trademark or registered trademark of SAP SE in the United States and other countries. Aruba is a trademark or registered trademark of Hewlett Packard Enterprise Development LP in the United States and other countries. All other trademarks referenced herein are the property of their respective owners.
In other recent industry news, Fujitsu America announced on January 9, 2018 that, "Fujitsu Extends the Global Reach for Biometrics-as-a-Service Offerings
News facts:
For the complete Fujitsu America Press Release: http://www.fujitsu.com/us/about/resources/news/press-releases/2018/fai-20180109.html
About SecuritySolutionsWatch.com
www.SecuritySolutionsWatch.com features thought leadership, content marketing, interviews about IT, IoT and security solutions. Our flagship "In The Boardroom" program, now in its 15th year, has delivered outstanding content about solutions from leading global brands such as: 3M, ASSA ABLOY, Cisco Security, Dell EMC, HP Cybersecurity, Fujitsu, Gemalto, HID Global, IBM, ImageWare, Intel, SAP, Siemens Security, Stanley Security, SONY Security, Yahoo, and Unisys just to name a few.
What's YOUR cybersecurity, physical security, mobility, payments, safety "smart" or blockchain solution?
We invite you to please join us "In The Boardroom" at www.SecuritySolutionsWatch.com. For a quick tour to see exactly how your brand will be featured, please contact Ali Eng on our publishing team via email: firstname.lastname@example.com, or phone: 1+914.690.9351 .
More details here: http://www.securitysolutionswatch.com/Main/ThoughtLeadershipOpportunity_July2017.pdf Media Kit here: http://www.securitysolutionswatch.com/MediaKit.html
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THIS PRESS RELEASE, AND ALL ADVERTISING, CONTENT AND ALL OTHER MATERIAL AND INFORMATION WHICH APPEARS ON SECURITYSOLUTIONSWATCH.COM AND/OR SECURITYSTOCKWATCH.COM, ONLINE AND/OR IN PRINT, IS SUBJECT TO OUR TERMS OF USE, CONDITIONS, AND DISCLAIMER HERE: www.SecuritySolutionsWatch.com/Main/Terms_of_Use.html.
Ali Eng
Publishing Team Leader
ALE (at) SecuritySolutionsWatch (dot) com


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Carry the library catalog on your smartphone or tablet. Search, request, and renew on the go. Look for "BookMyne" from iTunes for iOS or Google Play for Android OS.
While you're at it, store your library card on your smartphone by using a "loyalty card" app and never forget your card again.
Designed to manage customer loyalty cards as used by supermarkets, department stores, and fueling centers, these apps can also manage certain ID cards such as your library card.
In general, follow these steps. Have your library card handy. You want to know its 14-digit number.
- Search for "loyalty card" and install the app best suited to your needs. Many of them include a selection of loyalty cards and coupons.
- Create your library card by choosing "other" or "new" or whatever command used by the app for creating new cards.
- Give it a name, such as "Wilmington Public Library".
- In the space for card number, enter your 14-digit library card number without its spaces (which are just for readability anyway).
- The app asks for the "type" of barcode. Select "codabar" and it will create the barcode.
- Save all inputs and you're ready.
Next time you need your library card, go to your app, call up the card and its barcode to be scanned by the library.
Just putting a picture of your card's barcode in your phone may not be readable by barcode scanners. It's better to have the app create the barcode image.
As in all things technological, your mileage may vary.


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Grant, 2015, USA
On the diversity of the community: Although I was aware that the Fletcher Community would be diverse, I wasn't prepared for the amount of students and faculty who represent countries and communities from all over the world. This wide range of perspectives from different walks of life only helps to enrich the intellectual experience that is The Fletcher School. The only thing that comes close to matching the cultural diversity of Fletcher is the diversity of work experience that its peers and faculty have been a part of. Any interest in a potential career field is easily cultivated here.
On the importance of the Professional Development Program (PDP): One of the aspects of my educational experience that I am most thankful for is the Professional Development Program. Along with providing a wealth of academic knowledge, the Fletcher School prudently prepares its students for their future by helping them cultivate the tools to best market themselves to prospective employers. I find my exposure to Fletcher's excellent network of career professionals complimented by skills such as resume writing, interviewing, and drafting inquiries so that I feel confident come graduation time.
Fields of Study:
Activities involved in at Fletcher:
Education before Fletcher:
Experience before Fletcher:


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About Us
About Us
Delta County Libraries supports five libraries in Cedaredge, Crawford, Delta, Hotchkiss, and Paonia. The Library District maintains a varied collection of materials in print, audio and electronic formats as well as a wide range of technology for on-site and home use. Each library offers an annual schedule of dynamic programming for all ages including a Summer Reading Program, weekly storytimes, book clubs, technology help and much more. The Library District also provides adult education through programming, high school equivalency testing, and distance learning opportunities.
"Serving and Empowering People. Providing Resources for Life, Leisure and Learning."
- Communications and Outreach
To actively engage with our communities in order to build positive relationships, strengthen perceptions, and promote awareness of our libraries.
- Personnel
To support a creative and innovative team of appropriate size and expertise in a safe and stimulating work environment.
- Facilities
To maintain facilities that are resource efficient and environmentally responsible in design, construction, and renovation in order to provide welcoming, flexible, well-maintained spaces that support excellent library operation and services in our communities.
- Technology
To provide the technological infrastructure needed to support library operations and utilize progressing technology for the most effective and efficient delivery of library services.
- Collections
To strive to meet the evolving needs and preferences of our communities by building, maintaining, and promoting collections and improving information access and public delivery.
- Library Services and Programs
To provide effective and efficient library services and programs that reflect the needs and interests of our communities.
- Funding
To secure and manage funding to create a sustainable culture of continuous improvement and service excellence.
To view a complete, printable version of Delta County Libraries Strategic Plan, click here


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Writing With Childrenby Jill Monroe
This post was originally posted in March 2006.
Deciding to stay home with my children was not a difficult decision. There were many pros - the first obvious - I could stay home with my children. I always wanted to be a writer - now I could, and all my (small teaching/advising) income would be eaten up by daycare anyway. It was a no brainer.
And really, think of all the time I would have to write, write WRITE.
I had visions of children happily playing with toys at my feet while I typed away at the computer.
I'm sure you're laughing at this point. Because as any mommy who's tried to go to the bathroom in peace can attest, children cheerfully quietly playing while you're trying to do ANYTHING just doesn't happen. Unless of course you're trying to clean their room. Then they're anywhere but there.
So, I adjusted my schedule a bit. Instead of getting the scads written I'd hoped, I'd sneak in writing time during naps. Or after bedtime. When my husband began getting up at 5:30 in the morning, so did I. And believe me - that internal editor is not awake then!
I finaled in my first writing contest when the youngest was a baby and sold my first book before she went to Kindergarten. So, it can be done.
Now we've moved into a whole new phase for us. Booksignings, contract calls, RWA meetings - the kids have heard the names of my editors so much, they probably think we're related. They do think they're related to some of my critique partners (Aunt Donnell).
So, I've learned a few things. First, children are not impressed by your writing. Your booksigning. Or that you've been asked to speak at another writing group. Going to a bookstore to see your book on the shelves may MAY be cool the first time. It's not cool when you decide to visit every Wal-Mart, Target, Waldenbooks, Barnes and Noble and Borders within a 30 mile radius of the house.
My youngest tried to be helpful, pointing out every clinch cover book with a red spine, "There it is, Mommy!" really loud in each store. The oldest got to giggle every time she told a stranger her mommy's book was "Never Naughty Enough."
Kids are not swayed by bribery. I've told my kids that if I sold a fourth book - we'd take them to Disneyland. BUT, they'd have to let mommy work. Yeah, doesn't work. (Fourth book you ask? Hey, we still owe on the college student loans!)
Last year, my oldest asked me if I were famous. Now anyone who knows my sense of humor knows EXACTLY how I answered that. Man, what a difference a year makes. Now the kid KNOWS I'm not famous.
Lastly, sometimes you just have to sacrifice. There are times when I was watching Tellytubbies or playing Barbie when I'd think wistfully of my work in progress. But it seemed like I blinked and they were already in school. So not every book I wanted to write got written when they were little. Not every conference (or a cute outfit to wear at that conference) did I attend. But an impromptu hug or a smile because I stayed up all night sewing a Raggedy Ann costume makes it all worth it.
Although this year at The Romance Writers of America's National conference, Meg Cabot of Princess Diary fame will be signing. I plan to get autographed books for the kids (if someone can tell me how you get books signed while you're also signing - hopefully). THAT will impress the kids.
Labels: writing


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Researchers at Carnegie Mellon University's Intel Science and Technology Center in Embedded Computing have developed a robot that could help store owners keep items in stock. It's called AndyVision.
The robot has a Kinect sensor, image processing and machine learning algorithms, as well as 2D and 3D images of products and a floor plan of the store. Basically this robot patrols the store and determines if items are low or out of stock and even if they've been incorrectly shelved.
Employees then get the data on iPads and a public display updates an interactive map with product information for shoppers to see. The automaton is currently in CMU's campus store, but by next year a few local retailers will be testing it.
Source EngadgetFiled Under: Technology News


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City of Vancouver proclaims a Year of Reconciliation
June 20 2013
Vancouver's Year of Reconciliation is about building a common future together, one that acknowledges the historical impacts that have shaped the experiences of Aboriginal peoples across Canada - Mayor Gregor Robertson
The City of Vancouver is the first municipality in Canada to proclaim June 21, 2013 to June 20, 2014 as the Year of Reconciliation.
Vancouver Mayor Gregor Robertson will present the proclamation on behalf of Council to Chief Dr. Robert Joseph, Ambassador for Reconciliation Canada, on the eve of National Aboriginal Day, at a summit at the Morris J. Wosk Centre for Dialogue in downtown Vancouver on June 20, 2013.
The summit will be attended by cross-cultural groups, and includes speeches and presentations from Mayor Robertson, Chief Dr. Robert Joseph, representatives from the Squamish, Musqueam, and Tsleil-Waututh First Nations, the First Nations Leadership Council, and the Metro Vancouver Aboriginal Executive Council.
Helping all cultures within our community move forward with shared understanding and respect
In the spirit and tradition of dialogue and storytelling, which are an important part of Aboriginal culture and heritage, summit delegates will also participate in an afternoon of Engaged City dialogue that will help inform the Mayor and the City about important considerations that will guide the next steps in Vancouver's goal to become the world's first City of Reconciliation.
"Vancouver's Year of Reconciliation is about building a common future together, one that acknowledges the historical impacts that have shaped the experiences of Aboriginal peoples across Canada," explained Mayor Gregor Robertson. "We are supporting Reconciliation Canada as a way to help all cultures within our community develop new relationships, heal from the past, and move forward with shared understanding and respect."
A year-long initiative featuring gatherings, dialogue, public education, and public and arts programs
The City of Vancouver is embracing reconciliation through a year-long initiative that includes a series of gatherings, intercultural dialogue and storytelling workshops, public education, and cultural and arts programs as ways to mend the past, build shared understanding, and to create a legacy for meaningful change in society.
There are a host of City programs in the works that connect to Reconciliation. These include Aboriginal components within the Stanley Park 125 celebrations, the creation of a reconciliation legacy carving centre at Britannia Park, and the development of a Newcomer's Guide to Aboriginal Communities, Elders and Arts program.
Programming will also be included through the Vancouver Public Library's (VPL) dialogue sessions, author readings and documentaries, including a dedicated series with a British Columbia focus. VPL is re-energizing its Aboriginal Storyteller in Residence program, which returns later this year with a new storyteller who will share the tradition and craft in free workshops and sessions.
"Reconciliation is an opportunity for all Canadians to renew relationships, based on a shared understanding of our histories and our cultures and walk a path together for a shared tomorrow. To 'reconcile' is to weave a stronger and more vibrant social fabric, supported by the unique and diverse strengths of Canadians and their communities," said Chief Dr. Robert Joseph.
Four major events coming up in September
Reconciliation Canada will host four major events to help advance the work of Truth and Reconciliation Commission of Canada's (TRC) BC National Event in Vancouver this coming September. They include:
- Lighting the Flame of Reconciliation on September 16. A sacred fire will be lit to symbolize the commencement of the Week for Reconciliation;
- All Nations Canoe Gathering on September 17 from Kits Point to the Olympic Village along False Creek, to highlight traditional ceremonies and welcome all Nations to Coast Salish lands;
- A Walk for Reconciliation on September 22 that will bring people from all of Canada's many cultures to walk a path together in a shared commitment to reconciliation.
- A New Way Forward Ceremony will follow the Walk at Creekside Park on September 22, a call to action to develop future relationships between Aborginal and non-Aboriginal Canadians.
About residential schools in Canada
Residential schools in Canada date back to the 1870s. Over 130 residential schools were located across the country, with the last school closing in 1996. During this period, more than 150,000 First Nations, Métis, and Inuit children were removed from their families and placed in these schools. Many were forbidden to speak their language and denied their culture. It is estimated that more than 80,000 former students are living today. The ongoing impact of residential schools has been felt through several generations.
Founded in 2012, Reconciliation Canada is building new relationships between Aboriginal peoples and all Canadians, relationships built on a foundation of openness, dignity, understanding and hope. Reconciliation Canada is engaging people from every part of Canadian society in an open and honest conversation about our diverse histories and experiences in order to build resilient, sustainable communities.
Get more information about the Year of Reconciliation
Get more information on upcoming Year of Reconciliation events and register for the Walk for Reconciliation:


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Large Applicator Sticks 500-Count
ScripHessco Large Applicator Sticks 500-Count
- Dimensions:
3/4" x 6"
Product Overview
ScripHessco Large Applicator Sticks 500-Count
Large Applicator Sticks - 500 Count
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- Dimensions:
3/4" x 6"
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ScripHessco Large Applicator Sticks 500-Count
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Large Applicator Sticks 500-Count
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