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EvoMuse Defuse Writeup
EvoMuse Defuse Writeup
Defuse Write Up
Thermodynamics and Biochemistry.... A couple of mouthfuls that don't have the potential to make you fat. Calories, on the other hand, do.The feeding of Calories into the system known as the Human Body, and where those Calories finally end up, is a highly complex process. A number of sensing and processing pathways are put into play, each dealing with different nutrients (fat, carbs, etc), that either direct nutrients to be used as fuel, or stored as fat. The fat storage pathways are numerous but, lucky for us, can be manipulated, or inhibited, leaving potential jiggly ugliness circulating in the body to be burned for metabolic fuel.
We can't always remain perfectly strict on our diets (and let's be honest who wants to?) so for those times (muscle gaining cycles, holidays, vacations) we need a new approach to keeping lean. With Defuse, we have done just that.The Defuse formula helps to prevent fat gain by preventing the mechanisms for fat storage from working optimally, leaving the body with no choice but to burn that fat away.Evolutionary Muse - Inspire to Evolve
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The science behind Defuse is thick, but very digestible if you understand some key physiological terms. Give this pre-glossary a quick read, then as you go through the write up and come across one of these terms you may want to revisit the definition to get a better grasp. Or if you're already a super science nerd, feel free to skip over this section and get right to the meat.
Pre-adipocytes & pre-adipocyte differentiation
Pre-adipocytes are immature fat cells that have not yet developed distinguishing characteristics. Basically like the Army Reserve, they're called upon when needed, but instead of going into battle they are transformed into full-fledged fat cells through a process called differentiation. At this point they can start storing lipid droplets containing fats, cholesterol, and various metabolic machinery.
Peroxisome proliferator-activated receptor gamma (PPARy)
Of the three known PPAR subtypes (alpha, delta, gamma), PPARy is the only one that encourages nutrient storage upon activation. It is intricately involved in the uptake of carbohydrate and fat into adipose tissue, as well as being a key signal to trigger adipocyte differentiation.
CCAAT-enhancer binding proteins (C/EBP's)
C/EBP's include a family of six transcription factors, for our purposes we are just concerned with C/EBPa and C/EBPb. Both of these are directly involved in pre-adipocyte differentiation and work in conjunction with PPARy.
AMP-activated protein kinase (AMPk)
AMPk is a major regulator of cellular energy signaling. Upregulation triggers skeletal muscle fatty acid oxidation (fat burning), increased insulin sensitivity, and glucose uptake.
Normally, AMPk is triggered during conditions of low cellular energy (low glycogen storage, energy depletion during exercise, calorie restriction, etc). During times of caloric excess (which is exactly when you'll be using Defuse), AMPk is significantly downregulated, which is quite detrimental for fat loss; hence the inclusion of AMPk activators in the formula.
Transient receptor potential vanilloid receptor 1 (TrpV1)
A few years ago some groundbreaking research came out implicating this receptor as a major player in obesity. This is the receptor that capsaicin from chili peppers interacts with, and quite a bit of research has demonstrated that triggering TrpV1 has a significant effect on fat burning.
Hormone Sensitive Lipase (HSL)
HSL is crucial for the initial phase of fat loss. It is imperative for breaking down the stored triglyceride in a fat cell into free fatty acids (FFA's) so they can be transported for oxidation (burning). The breakdown of stored triglyceride into FFA's (before transport and oxidation of the fat even occur) is a three-step process, and HSL governs the first step, and is also the rate-limiting step. Boosting HSL allows the other two steps to do more work, which allows for more fat to be burned.
Fatty Acid Synthase (FAS)
Think of FAS as the anti-HSL, basically performing the opposite function, encouraging the storage of fat. It is comprised of a group of enzymes regulated upstream by SREBP-1c, which is triggered by insulin. Research shows a significant upregulation of FAS in obesity, coupled with suppressed HSL.
Brown Adipose Tissue (BAT)
BAT is structurally and functionally different from white adipose tissue (WAT). BAT contains several, small lipid droplets surrounding the large nuclear machinery in the middle, whereas WAT contains one huge lipid droplet with a small nucleus near the cell wall. That right there gives some indication of the function of the BAT cell, along with its high mitochondria density and UCP1 expression. BAT's main function is generating heat by burning calories; the numerous small lipid droplets release their fat in response to cold in order to elevate body temperature. People with higher BAT levels (or better BAT signaling) take longer to start shivering in the cold, as their bodies are able to maintain better homeostatic thermoregulation.
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Acacia Catechins
Where does it come from?
Found growing in various parts of China and India, Acacia Catechu is a tall thorny tree. It was selected for inclusion in Defuse as a source of epicatechin and EGCG.
Primary Effects
PPARy and C/EBP
Acacia Catechins have been shown to suppress pre-adipocyte differentiation through the blockade of two important fat storage proteins, C/EBP and PPARy, which has a downstream inhibition on the master fat storing gatekeeper, FAS (1).
Platycodon saponins
Where does it come from?
Platycodin d. is isolated from the roots of the Platycodon grandiflorum plant, found in East Asia.
Primary Effects
AMPk Activation
Fat loss and fat gain are moderated by numerous complex mechanisms, and AMPk is a key player in this flux. Generally speaking, bolstering AMPk activation is great for fat loss, in the right amount. Platycodin d. has been shown in multiple studies to significantly inhibit fat gain and increase fat burning through AMPk activation. Downstream, this AMPk activation attenuates activation of SREBP-1 and fatty acid synthase (FAS), two hormones responsible for fat storage. This is done in a novel way by triggering SIRT1 and CaMMK-b (2–4).
PPAR-y and C/EBPa Modulation
Platycon d. has been shown to reduce abdominal and whole body fat accumulation in mice fed an obesogenic diet by PPAR-y and C/EBPa (3). Basically they gave mice Platycodon d., tried to make them fat, and couldn't do it.
Adipokine and Glucose Management
Another recent study trying to fatten up mice found that Platycodon d. was able to kick-start adiponectin (a fat burning adipokine) locally in fat cells while keeping it stable in serum compared to the placebo group. It was also able to suppress TNFa (an inflammatory cytokine) locally in fat cells. This resulted in reduced food intake and reduced fat accumulation while increasing glucose uptake in skeletal muscle (5). With regards to glucose, another study showed it was able to reduce blood sugar without stimulating insulin release, which is great for enhancing fat burning as well as long term health (6).
Where does it come from?
Baicalin is a flavone found in the herb blue skullcap.
Primary Effects
AKt, CaMKKb, AMPk, ACC, PPARy, C/EBP, FAS, KLF-2 & KLF-15
Baicalin has been shown to downregulate PPAR-y and C/EBPs; it does this by suppressing Akt phosphorylation through inhibition of PDK1 (7,8). The net result of this, among other things, is going to be inhibiting fat accumulation by attenuating preadipocyte differentiation.
Baicalin is another AMPk activator, which does so through the favorable CaMMK pathway like Platycodin d. (9). Researchers in Shanghai conducted a profound study in mice fed a high fat diet (HFD) with or without baicalin supplementation (10). Keep in mind that mice don't normally eat a high fat diet, and their metabolic machinery is ill adapted to do so. After 16 weeks, the bicalin group saw the following effects:
Suppression of body weight gain normally caused by the HFD
Reduced visceral fat
Decreased cholesterol
Decreased circulating FFA's (a sign of increased fat oxidation)
Decreased circulating insulin
Reduced TNF-a (a potent inflammatory cytokine)
Reduced liver fat gain
Stimulation of AMPk and ACC
Decreased SREBP-1c and FAS
Another study out of Korea supported the previously seen fat loss potential and concluded that baicalin upregulates anti-fat storage regulators (KLF-2) and downregulates pro-fat storing regulators (KLF-15) which results in an inhibition of cellular fat accumulation (8). This is a perfect storm for prevention of fat gain.
Methyl Cinnamate
Where does it come from?
Methyl Cinnimate (MC) is an ester of cinnamic acid found in several plants and spices.
Primary Effects
MC again targets pre-adipocytes through modulation of PPAR-y, SREBP-1, and C/EBPa, CaMMK2, and AMPk, thereby reducing the ability of the body to accumulate fat storage (11).
Salvia miltiorrhiza
Where does it come from?
Salvia miltiorrhiza is an Asian perennial plant from the Salvia genus.
Primary Effects
DGAT, Glucose Sensitivity, Hepatic Lipid Metabolism
Diglyceride acetyltransferase (DGAT) is the enzyme responsible for the third and final step in producing a triglyceride from glycerol and fatty acids. Inhibit DGAT, which Salvia m. has been shown to do, and you reduce fat accumulation and increase leptin sensitivity significantly (12) . If your body wants to store more fat; it cranks up DGAT activity.
Salvia m. has also been shown in research to improve uptake of glucose in skeletal muscle, thereby reducing fat storage through a 2nd angle (13).
When feeding two groups of rats a fattening diet for six weeks, the control group showed increased body fat accumulation, hyperinsulinemia, hyperlipidemia, and increased liver enzymes. The group fed the same diet in conjunction with Salvia m. did not show any of these negative effects from the high fat diet (14).
Raspberry Ketone
Where does it come from?
Raspberry Ketone (RK) is a natural phenolic, aromatic compound found in raspberries, cranberries and blackberries.
Primary Effects
Activating the Transient Receptor Potential Vanilloid Type 1 protein (TRPV1) offers numerous benefits for fat loss and general health, including prevention of adipogenesis and obesity (15).
Through modulation of norepinephrine (NE) and hormone sensitive lipase (HSL), RK appears to be a powerhouse for encouraging fat loss and prevention of fat gain. When mice were fed fattening diet, RK prevented visceral and liver fat accumulation as well as reversing the fat gain in previously obese mice (16). Recently liver fat has been implicated in metabolic disturbances to an even greater degree than the previous villain, visceral fat, so this is a benefit of great magnitude for overall health (17).
18b-glycyrrhetinic acid
Where does it come from?
18b-glycyrrhetinic acid (18b-GA) is a metabolite of glycyrrhetinic acid with very unique properties found in the licorice herb.
Primary Effects
While high doses of licorice/glycyrrhetinic acid have been shown to inhibit the enzyme 11b-HSD, which is responsible for converting cortisol to the inactive form cortisone (18), the low dose of this specific 18b metabolite have some important yet unrelated effects.
PPARy, C/EBPa, HSL, HbA1c, Inflammation
18b-GA is another ingredient in DeFuse selected for its potent inhibitory effect on the likely now familiar PPARy and C/EBPa pathway. A recent university study out of South Korea found that 18b-GA was able to decrease lipid accumulation by downregulation of PPARy and C/EBPa in maturing pre-adipocytes. In addition to this effect on pre-adipocytes, it was also able to increase fat release, upregulate HSL, adipose TG lipase and perilipin in mature fat cells (19). So basically 18b-GA is going to prevent immature fat cells from becoming fat cells, and increase lipolysis in mature fat cells, a perfect two pronged attack.
Another study out of India showed that 18b-GA was able to control blood glucose and HbA1c in diabetic rats on par with the potent pharmaceutical glibenclamide (20). It also appears to have a significant effect on preventing free fatty acid induced lipid accumulation and lipotoxicity by stabilizing mitochondrial lysosomes and improving liver function (21). Finally, 18b-GA has also been shown to be anti-inflammatory by reducing IL-8 (22). Current research shows that inflammation is likely a major contributing factor to fat gain, so by reducing inflammatory interleukins we can help create a more optimal hormonal environment.
Where does it come from?
Gingerol, found in ginger, is chemically similar to capsaicin and piperine. Once cooked, gingerol becomes zingerone.
Primary Effects
PPARy, C/EBPa, FAS, SREBP-1c, Acetyl-CoA, Akt, AP2/4, ROS, Inflammation
In a university study out of Tokyo, researchers looked at the effect of gingerol on rats fed a fattening diet to see if it could alleviate any of the damage. They found it was able to reduce plasma insulin, SREBP-1c, and liver acetyl-CoA carboxylase, which attenuated both body weight gain and fat accumulation (23).
6-gingerol is also an effective player in our main theme of targeting pre-adipocyte differentiation. Both in vitro and in vivo, we see anti-adipogenic properties through reduction in PPARy, C/EBPa and FAS (24,25). The researchers performing these studies also found that it was able to reduce levels of something called adipocyte-specific fatty acid binding protein (aP2, also called FABP4), which is a carrier protein for fatty acids and has become an emerging target protein for treating diabetes and obesity (26,27).
In addition to the direct anti-adipogenic effects, gingerol can also control oxidative damage by reducing intracellular ROS and boosting glutathione, as well as reduce inflammation by blocking TNF-a, NF-kB and PKC signaling (28,29).
Where does it come from?
Cinchonine is a natural compound found in Cinchona bark, indigenous to the Western Andes.
Primary Effects
During overfeeding, cinchonine supplemented subjects gained 40% less weight, 25% less visceral fat, and had lower levels of triglycerides, glucose, serum cholesterol and free fatty acids (30). It also inhibited the diet induced upregulation of inflammatory cytokines by inhibiting Toll Like Receptor 2 (TLR2). In summary, it was shown to reduce fat gain and inflammation compared to control groups when given a fattening diet.
(-)Hydroxycitric acid
Where does it come from?
Hydroxycitric Acid (HCA) is found in the tropical plant Garcinia cambogia.
Primary Effects
HCA has been shown to favorably alter the expression of genes that regulate adipogenesis and lipolysis, which makes it a great addition to the Defuse formula (31). New research shows that it appears to do so by blocking a key enzyme called atp-citratelyase (32). In a previous study, HCA was also shown to reduce fatty acid synthesis from glucose (33).
Where does it come from?
Anthocyanins and betalains are a class of pigmentations found in various plants, fruits and flowers, with numerous health-promoting effects.
Primary Effects
PPARy, Adiponectin, NPY, Glucose, Leptin, Resistin
Once again, we're targeting inhibition of PPARy to suppress fat storage. Anthocyanins have been shown to do just this, causing suppressed pre-adipocyte differentiation and lipid accumulation (34). A brand new university study out of Korea looked at rats on a normal diet vs. rats on a normal diet plus anthyocyanins for 40 days (35). Here's what they found in the supplemented group:
Significantly lower body weight
Reduced fat cell size
Reduced expression of neuropeptide Y (a neurotransmitter that signals increased food intake and fat storage) and of protein kinase A (a regulator of cellular energy storage).
Another study looked at the effects of anthocyanin supplementation over 10 weeks and found that it lowered total cholesterol, triglycerides, serum leptin and resistin. The researchers concluded that anthocyanins "…posess a preventative potential for obesity-associated diseases" (36).
Other studies have shown an anti-obesity effect as well, demonstrating resistance to fat gain with supplementation (37,38). Betalains specificaly have been shown to boost adiponectin, act as an antioxidant, and prevent LDL oxidation (39–41).
Where does it come from?
Loranthus is a parasitic plant found growing on branches of woody trees, from the Loranthaceae family.
Primary Effects
FAS inhibition, glucose
Loranthus has several studies supporting its ability to potently inhibit FAS, making it a perfect choice to prevent fat gain, and a key ingredient in the formula.
Initially, Tian et. al, discovered that loranthus potently inhibits FAS to a greater extent than cerulenin and C75 (currently used to inhibit FAS in a laboratory setting), and also reduced body weight in tested subjects (42). Next, they established an IC50 value (a measurement used to determine the inhibitory potency of a compound) and found that loranthus has both a fast acting and long acting effect on FAS inhibition (43). Finally, they determined that the FAS inhibitory activity of loranthus comes from a specific family (Loranthaceae), so it is important to use this form, which we have done in Defuse (44).
At least two other studies have shown the ability of loranthus to favorably regulate blood glucose levels, in diabetic and non-diabetic subjects (45,46).
Citrus aurantium
Where does it come from?
Citrus aurantium (CA) refers to a citrus tree and its fruit, which contains N-methyltyramine, octopamine and synephrine.
Primary Effects
PPARy, C/EBP (a&b), FAS, aP2
Quite a bit of research has been done on CA, for now we just want to focus on a couple of studies that make it highly relevant for its inclusion in the Defuse formula.
The first noteworthy study looked at CA's effect on pre-adipocyte differentiation, and it turned out to do pretty much everything we want in an anti-fat gain compound. It was shown to downregulate PPARy, C/EBPb and C/EBPa (expression of C/EBPa makes fat cells more sensitive to insulin). In addition to this, it also dramatically decreased FAS and aP2, as well as other fat signaling pathways. This demonstrates CA's ability to positively manipulate the fat storage vs. fat burning pathway and inhibit adipocyte differentiation (47).
Finally, a recent meta-analysis looking at a combination of 20 published and unpublished studies including 360 human subjects concluded that supplemental CA increases resting metabolic rate and energy expenditure (48).
Lotus leaf
Where does it come from?
Lotus leaf comes from the aquatic lotus plant in the Nelumbonaceae family.
Primary Effects
SREBP-1c, REE, a-glucosidase, GLUT4, AGEs
Keeping with the recurring theme of attacking pre-adipocyte differentiation, lotus leaf could be a potentially big player in this assault. Research has demonstrated the ability of lotus to decrease SREBP-1c and triglyceride accumulation during adipogenesis, increase lipolysis, and decrease adipocyte differentiation capacity (49).
In a study out of Japan, researchers took the now hopefully familiar route of trying to fatten up mice and rats with and without lotus supplementation and measured various obesity related parameters. They found that the supplemented group was able to prevent fat gain as well as hepatic triglycerides, coupled with an inhibited ability to absorb lipids and an accelerated rate of fat oxidation and resting energy expenditure (50).
A 2013 study out of Korea looked at the effect of lotus supplementation for 7 weeks in animals with diabetes. They found that lotus was an extremely potent inhibitor of an enzyme called a-glucosidase, which lowers the rate of glucose absorption and extends digestion time, leading to a lower post-prandial glucose response (51). The same study also demonstrated the ability of lotus to lower plasma triglycerides and total cholesterol. Inhibition of a-glucosidase has been shown to reduce triglyceride uptake into fat cells, decrease hepatic lipogenesis, favorably effect skeletal muscle GLUT4 receptor density density, and diminish the production of Advanced Glycation End products (AGEs) (52).
Olive Leaf extract
Where does it come from?
Olive leaf extract (OLE) is derived from the leaves of the olive plant; we have selected an extract with a high potency of oleuropein, a phenolic compound with some interesting properties relating to prevention of fat gain.
Primary Effects
PPARy, C/EBPa, RQ, AGEs, Insulin, Glucose
We'll kick this one off with the current theme, OLE is yet another ingredient in the Defuse formula that prevents adipocyte differentiation through inhibition/downregulation of PPARy and C/EBPa (53).
A study published in the Journal of Nutrition found that OLE supplementation increased V02, reduced myocardial oxidative stress, and lowered respiratory quotient (RQ- lower levels indicate more fat oxidation vs. carbohydrate oxidation) (54). In another study published in Nutrition, researchers overfed two groups of rats for eight weeks, then gave one group OLE and continued to overfeed both groups for another eight weeks. The non-supplemented group developed metabolic syndrome, including elevated abdominal and liver fat, collagen accumulation in the heart and liver, elevated oxidative stress markers, abnormal cholesterol and impaired glucose tolerance. The group supplemented with OLE either improved or normalized all of those parameters, demonstrating a potent protective effect against overfeeding (53).
In a brand new human study out of The University of Aukland, overweight men at risk for metabolic syndrome were given supplementation with OLE for 12 weeks; researchers noted a 15% improvement in insulin sensitivity along with an almost 30% improvement in pancreatic beta cell responsiveness (the cells that produce insulin) (55). An improvement in fasting insulin and HbA1c was also noted in a previous human study with 79 diabetic adults (56).
Finally, OLE is another ingredient in the formula that acts as an anti-glycation agent, reducing production of AGEs (57).
Galega officionalis
Where does it come from?
Galega officinalis is an herbaceous plant in the Faboideae family native to the Middle East, containing a potent compound called guanidine.
Primary Effects
AMPK, FAS, Acetyl-CoA, GLUT4, Glucose
Galega is going to contribute to fat gain inhibition through some familiar mechanisms, and looks to be quite a promising compound. It has been shown to activate AMPk, increase GLUT4 translocation, and increase skeletal muscle glucose uptake in vitro and in vivo (58,59).
An animal study out of Glasgow again demonstrated AMPk activation, as well as inhibition of Acetyl-CoA carboxylase and FAS, increased fat oxidation, and a reduction in body weight (60).
The most impressive research on galega looked at the effect of supplementation for 28 days on normal and obese mice and measured several parameters. In normal mice, supplementation caused weight loss and a voluntary reduction of food intake. Interestingly, after cessation of the supplement, food intake increased back to normal but the weight loss was maintained. The obese mice supplementing with galega also showed reduced food intake, and the researchers noted a "striking absence of body fat" during post-mortem examinations. Both groups showed a reduction in fasting blood glucose, and the obese group also showed a reduction in serum insulin (61).
Panax ginseng berry extract
Where does it come from?
Panax ginseng berry extract (GBE) comes from Ginseng; a perennial plant from the Araliaceae family.
Primary Effects
AMPk, FAS, glucose, SREBP-1c
GBE has been shown to inhibit lipogenesis during overfeeding by suppressing FAS and SREBP-1c, while upregulating AMPk. Supplementation was also shown to reverse diet-induced blood sugar cholesterol elevations, while reducing hepatic glucose output (62). Several studies in obese and/or diabetic animals have demonstrated a favorable modulation of blood glucose, loss of body weight, and even pancreatic beta cell regeneration (63–66).
Forskolin 60%
Where does it come from?
Forskolin is a diterpene from the Coleus forskohlii plant.
Primary Effects
Forskolin is well known to effectively target cAMP in adipose tissue, which, among other things, mimics exercise and caloric restriction.
A 12 week randomized, double-blind placebo study out of the University of Kansas found that forskolin supplementation caused a decrease in body fat and an increase in lean body mass compared to the placebo group (67). The even better news is that this study only used a 10% extract; we have obtained a far more potent 60% extract for Defuse. It has also been suggested to help mitigate weight gain in overweight human subjects (68).
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Where does it come from?
Silibinin comes from milk thistle seeds, and is the main active component of silymarin.
Primary Effects
Most people are well aware of Milk Thistle's profound effect on liver health, but silibinin is included in Defuse for a different reason.
ATGL, Insulin, FFA's, Resistin, TNFa, oxLDL
Silibinin is the first ingredient in the formula to upregulate something called adipose triglyceride lipase (ATGL), which is an enzyme responsible for initiating the breakdown of stored fat (triglyceride) inside the adipocyte (69). Silibinin has also been shown to reduce serum fatty acids, improve skeletal muscle insulin resistance, reduce visceral fat, downregulate resistin, and improve glucose metabolism by downregulating gluconeogenesis genes and supporting the Akt pathway (69–71).
And for some bonus points, silibinin also inhibits oxidation of LDL particles, decreases lipid peroxidation and lowers TNFa (71,72)
Rosemary Leaf Extract (carnosic acid)
Where does it come from?
Rosemary is a Mediterranean perennial herb; the leaf extract is a source of a natural diterpene called carnosic acid.
Primary Effects
PPARy, C/EBP, Glucose, Gastric Lipase, Hepatic Lipase
Carnosic acid (CA) does pretty much everything you could ask from an anti-adipogenic compound. Again we're going after PPARy and C/EBPa inhibition, and CA has a unique effect on restructuring the ratios of different forms of C/EBPb, the combined result being inhibition of adipogenesis (73,74).
A recent study out of Switzerland boasted some impressive results in overfed mice supplemented with Rosemary leaf extract for 50 days, showing almost a 60% reduction in fat gain and 40% reduction in hepatic triglyceride levels. The researchers determined this effect was likely due to an inhibition of pancreatic lipase activity, and concluded Rosemary extract "…can limit weight gain induced by a high-fat diet and protect against obesity-related liver steatosis" (75).
CA has been shown in several other studies to significantly reduce body weight and body fat in lean and obese individuals, lower triglycerides, total cholesterol and insulin, reduce visceral fat, improve liver enzymes, favorably modulate glucose and glucose tolerance, inhibit gastric lipase (thereby reducing fat absorption), and inhibit pre-adipocyte differentiation (74,76–78).
Stearoyl Vanillylamide (capsaicin analogue)
Where does it come from?
Stearoyl Vanillylamide (SV) is a non-pungent analogue of capsaicin, the active component of chili peppers.
Primary Effects
TrpV1, BAT, REE
If you've been paying attention to obesity research the past few years, you've likely heard of the transient receptor potential vanilloid (TrpV1). See the description in the intro of the article if you need a quick explanation. Multiple studies have demonstrated SV/capsaicin's ability to act as a potent TrpV1 agonist leading to decreases in body fat and increases in energy expenditure (80,81).
Brown Adipose Tissue (BAT) has taken an interesting journey in the research over the years, and for a long time was suspected to be negligible in adult humans, and therefore an unfruitful target for obesity and weight loss. However, new research is showing we were likely wrong all along, and that BAT is indeed a "…regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders" (82). SV has been shown to have a profound effect in several studies on BAT upregulation through TrpV1 binding (80–83). The net effect of this BAT activation is a significant increase in fat oxidation and energy expenditure. Two recent meta-analyses looking at the summation of the data determined that capsaicin supplementation increases VO2, energy expenditure and fat loss in humans (84,85).
Psychologically and emotionally we need time off, and often that time off involves eating and drinking large meals with friends and family. While we want, and need, to participate we can often find our other, fitness-related, goals compromised.
Defuse gives us a much-needed tool for physique enhancement. Defuse helps prevent fat gain that happens with occasional caloric surplus (vacation and Holidays), and short burst muscle gaining cycles. Incorporating Defuse strategically as directed will minimize fat gain and help to maintain your much-desired leanness.
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1. Furuyashiki T, Nagayasu H, Aoki Y, Bessho H, Hashimoto T, Kanazawa K, et al. Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. Biosci. Biotechnol. Biochem. [Internet]. 2004 Nov [cited 2013 Oct 7];68(11):2353–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15564676
2. Hwang YP, Choi JH, Kim HG, Khanal T, Song GY, Nam MS, et al. Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells. Toxicol. Appl. Pharmacol. [Internet]. 2013 Mar 1 [cited 2013 Oct 4];267(2):174–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23319015
3. Lee EJ, Kang M, Kim YS. Platycodin D inhibits lipogenesis through AMPKα-PPARγ2 in 3T3-L1 cells and modulates fat accumulation in obese mice. Planta Med. [Internet]. 2012 Sep [cited 2013 Oct 4];78(14):1536–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22872592
4. Hwang YP, Choi JH, Kim HG, Lee H-S, Chung YC, Jeong HG. Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced HepG2 cells. Food Chem. [Internet]. 2013 Sep 1 [cited 2013 Oct 4];140(1-2):115–23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23578622
5. Ahn Y-M, Kim SK, Kang J-S, Lee B-C. Platycodon grandiflorum modifies adipokines and the glucose uptake in high-fat diet in mice and L6 muscle cells. J. Pharm. Pharmacol. [Internet]. 2012 May [cited 2013 Oct 4];64(5):697–704. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22471365
6. Zheng J, He J, Ji B, Li Y, Zhang X. Antihyperglycemic effects of Platycodon grandiflorum (Jacq.) A. DC. extract on streptozotocin-induced diabetic mice. Plant Foods Hum. Nutr. [Internet]. 2007 Mar [cited 2013 Oct 4];62(1):7–11. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17226070
7. Kwak DH, Lee J-H, Song KH, Ma JY. Inhibitory effects of baicalin in the early stage of 3T3-L1 preadipocytes differentiation by down-regulation of PDK1/Akt phosphorylation. Mol. Cell. Biochem. [Internet]. 2013 Oct 4 [cited 2013 Oct 7]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/24091917
8. Lee H, Kang R, Hahn Y, Yang Y, Kim SS, Cho SH, et al. Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway. Phytother. Res. [Internet]. 2009 Nov [cited 2013 Oct 7];23(11):1615–23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19813240
9. Ma Y, Yang F, Wang Y, Du Z, Liu D, Guo H, et al. CaMKKβ is involved in AMP-activated protein kinase activation by baicalin in LKB1 deficient cell lines. PLoS One [Internet]. 2012 Jan [cited 2013 Oct 7];7(10):e47900. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
10. Guo H, Liu D, Ma Y, Liu J, Wang Y, Du Z, et al. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol. Sin. [Internet]. 2009 Nov [cited 2013 Oct 7];30(11):1505–12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19890358
11. Chen Y-Y, Lee M-H, Hsu C-C, Wei C-L, Tsai Y-C. Methyl cinnamate inhibits adipocyte differentiation via activation of the CaMKK2-AMPK pathway in 3T3-L1 preadipocytes. J. Agric. Food Chem. [Internet]. 2012 Feb 1 [cited 2013 Oct 7];60(4):955–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22273148
12. Ko JS, Ryu SY, Kim YS, Chung MY, Kang JS, Rho M-C, et al. Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza. Arch. Pharm. Res. [Internet]. 2002 Aug [cited 2013 Nov 4];25(4):446–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12214853
13. Tao W, Deqin Z, Yuhong L, Hong L, Zhanbiao L, Chunfeng Z, et al. Regulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese Medicine. J. Ethnopharmacol. [Internet]. 2010 Apr 21 [cited 2013 Nov 4];128(3):575–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20123010
14. Tan Y, Lao W, Xiao L, Wang Z, Xiao W, Kamal MA, et al. Managing the combination of nonalcoholic Fatty liver disease and metabolic syndrome with chinese herbal extracts in high-fat-diet fed rats. Evid. Based. Complement. Alternat. Med. [Internet]. 2013 Jan [cited 2013 Nov 4];2013:306738. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
15. Zhang LL, Yan Liu D, Ma LQ, Luo ZD, Cao TB, Zhong J, et al. Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ. Res. [Internet]. 2007 Apr [cited 2010 Sep 6];100(7):1063–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17347480
16. Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H. Anti-obese action of raspberry ketone. Life Sci. [Internet]. 2005 May [cited 2010 Sep 12];77(2):194–204. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15862604
17. Fabbrini E, Magkos F, Mohammed BS, Pietka T, Abumrad NA, Patterson BW, et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc. Natl. Acad. Sci. U. S. A. [Internet]. 2009 Sep [cited 2010 Aug 11];106(36):15430–5. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
18. Krähenbühl S, Hasler F, Frey BM, Frey FJ, Brenneisen R, Krapf R. Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans. J. Clin. Endocrinol. Metab. [Internet]. 1994 Mar [cited 2013 Oct 29];78(3):581–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8126129
19. Moon M-H, Jeong J-K, Lee Y-J, Seol J-W, Ahn D-C, Kim I-S, et al. 18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis. Biochem. Biophys. Res. Commun. [Internet]. 2012 Apr 20 [cited 2013 Oct 29];420(4):805–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22465130
20. Kalaiarasi P, Pugalendi KV. Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats. Eur. J. Pharmacol. [Internet]. 2009 Mar 15 [cited 2013 Oct 29];606(1-3):269–73. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19374864
21. Wu X, Zhang L, Gurley E, Studer E, Shang J, Wang T, et al. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. Hepatology [Internet]. 2008 Jun [cited 2013 Oct 29];47(6):1905–15. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18452148
22. Kang O-H, Kim J-A, Choi Y-A, Park H-J, Kim D-K, An Y-H, et al. Inhibition of interleukin-8 production in the human colonic epithelial cell line HT-29 by 18 beta-glycyrrhetinic acid. Int. J. Mol. Med. [Internet]. 2005 Jun [cited 2013 Oct 29];15(6):981–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15870903
23. Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, et al. Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. J. Med. Chem. [Internet]. 2011 Sep 22 [cited 2013 Oct 29];54(18):6295–304. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21851089
24. Tzeng T-F, Liu I-M. 6-gingerol prevents adipogenesis and the accumulation of cytoplasmic lipid droplets in 3T3-L1 cells. Phytomedicine [Internet]. 2013 Apr 15 [cited 2013 Oct 29];20(6):481–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23369342
25. Tzeng T-F, Chang CJ, Liu I-M. 6-Gingerol Inhibits Rosiglitazone-Induced Adipogenesis in 3T3-L1 Adipocytes. Phytother. Res. [Internet]. 2013 Mar 21 [cited 2013 Oct 29]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/23519881
26. Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature [Internet]. 2007 Jun 21 [cited 2013 Nov 5];447(7147):959–65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17554340
27. Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. [Internet]. 2005 Feb [cited 2013 Nov 5];1(2):107–19. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16054052
28. Lee C, Park GH, Kim C-Y, Jang J-H. [6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system. Food Chem. Toxicol. [Internet]. 2011 Jun [cited 2013 Oct 29];49(6):1261–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21396424
29. Lee T-Y, Lee K-C, Chen S-Y, Chang H-H. 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macrophages. Biochem. Biophys. Res. Commun. [Internet]. 2009 Apr 24 [cited 2013 Oct 29];382(1):134–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19268427
30. Jung SA, Choi M, Kim S, Yu R, Park T. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Res. [Internet]. 2012 Jan [cited 2013 Oct 29];2012:541204. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
31. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr. Genomics [Internet]. 2008 Jun [cited 2013 Oct 29];9(4):239–51. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
32. Vasques CAR, Schneider R, Klein-Júnior LC, Falavigna A, Piazza I, Rossetto S. Hypolipemic Effect of Garcinia cambogia in Obese Women. Phytother. Res. [Internet]. 2013 Oct 17 [cited 2013 Oct 29]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/24133059
33. Hood RL, Beitz DC, Johnson DC. Inhibition by potential metabolic inhibitors of in vitro adipose tissue lipogenesis. Comp. Biochem. Physiol. B. [Internet]. 1985 Jan [cited 2013 Oct 29];81(3):667–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/4028683
34. Kim H-K, Kim JN, Han SN, Nam J-H, Na H-N, Ha TJ. Black soybean anthocyanins inhibit adipocyte differentiation in 3T3-L1 cells. Nutr. Res. [Internet]. 2012 Oct [cited 2013 Oct 29];32(10):770–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23146774
35. Badshah H, Ullah I, Kim SE, Kim T-H, Lee HY, Kim MO. Anthocyanins attenuate body weight gain via modulating neuropeptide Y and GABAB1 receptor in rats hypothalamus. Neuropeptides [Internet]. 2013 Jul 2 [cited 2013 Oct 29]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/23830691
36. Graf D, Seifert S, Jaudszus A, Bub A, Watzl B. Anthocyanin-Rich Juice Lowers Serum Cholesterol, Leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats. PLoS One [Internet]. 2013 Jan [cited 2013 Oct 22];8(6):e66690. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
37. Prior RL, E Wilkes S, R Rogers T, Khanal RC, Wu X, Howard LR. Purified Blueberry Anthocyanins and Blueberry Juice Alter Development of Obesity in Mice Fed an Obesogenic High-Fat Diet (dagger). J. Agric. Food Chem. [Internet]. 2010 Feb 11; Available from: http://www.ncbi.nlm.nih.gov/pubmed/20148514
38. Tsuda T. Regulation of adipocyte function by anthocyanins; possibility of preventing the metabolic syndrome. J. Agric. Food Chem. [Internet]. 2008 Mar 13 [cited 2013 Oct 29];56(3):642–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18211021
39. Tsuda T, Ueno Y, Aoki H, Koda T, Horio F, Takahashi N, et al. Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem. Biophys. Res. Commun. [Internet]. 2004 Mar 26 [cited 2013 Oct 29];316(1):149–57. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15003523
40. Tesoriere L, Butera D, D'Arpa D, Di Gaudio F, Allegra M, Gentile C, et al. Increased resistance to oxidation of betalain-enriched human low density lipoproteins. Free Radic. Res. [Internet]. 2003 Jun [cited 2013 Oct 29];37(6):689–96. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12868496
41. Tesoriere L, Butera D, Allegra M, Fazzari M, Livrea MA. Distribution of betalain pigments in red blood cells after consumption of cactus pear fruits and increased resistance of the cells to ex vivo induced oxidative hemolysis in humans. J. Agric. Food Chem. [Internet]. 2005 Mar 23 [cited 2013 Oct 29];53(4):1266–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15713051
42. Tian W-X, Li L-C, Wu X-D, Chen C-C. Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase. Life Sci. [Internet]. 2004 Mar 26 [cited 2013 Oct 29];74(19):2389–99. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14998716
43. Wang Y, Zhang S-Y, Ma X-F, Tian W-X. Potent inhibition of fatty acid synthase by parasitic loranthus [Taxillus chinensis (dc.) danser] and its constituent avicularin. J. Enzyme Inhib. Med. Chem. [Internet]. 2006 Mar [cited 2013 Oct 29];21(1):87–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16570511
44. Wang Y, Deng M, Zhang S-Y, Zhou Z-K, Tian W-X. Parasitic loranthus from Loranthaceae rather than Viscaceae potently inhibits fatty acid synthase and reduces body weight in mice. J. Ethnopharmacol. [Internet]. 2008 Aug 13 [cited 2013 Oct 29];118(3):473–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18583073
45. Osadebe PO, Okide GB, Akabogu IC. Study on anti-diabetic activities of crude methanolic extracts of Loranthus micranthus (Linn.) sourced from five different host trees. J. Ethnopharmacol. [Internet]. 2004 Dec [cited 2013 Oct 28];95(2-3):133–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15507325
46. Obatomi DK, Bikomo EO, Temple VJ. Anti-diabetic properties of the African mistletoe in streptozotocin-induced diabetic rats. J. Ethnopharmacol. [Internet]. 1994 Jun [cited 2013 Oct 29];43(1):13–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7967645
47. Kim G-S, Park HJ, Woo J-H, Kim M-K, Koh P-O, Min W, et al. Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. BMC Complement. Altern. Med. [Internet]. 2012 Jan [cited 2013 Nov 5];12:31. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
48. Stohs SJ, Preuss HG, Shara M. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Int. J. Med. Sci. [Internet]. 2012 Jan [cited 2013 Oct 29];9(7):527–38. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
49. Siegner R, Heuser S, Holtzmann U, Söhle J, Schepky A, Raschke T, et al. Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle. Nutr. Metab. (Lond). [Internet]. 2010 Jan [cited 2013 Oct 29];7:66. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
50. Ono Y, Hattori E, Fukaya Y, Imai S, Ohizumi Y. Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J. Ethnopharmacol. [Internet]. 2006 Jun 30 [cited 2013 Oct 29];106(2):238–44. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16495025
51. Kim A-R, Jeong S-M, Kang M-J, Jang Y-H, Choi H-N, Kim J-I. Lotus leaf alleviates hyperglycemia and dyslipidemia in animal model of diabetes mellitus. Nutr. Res. Pract. [Internet]. 2013 Jun [cited 2013 Oct 29];7(3):166–71. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
52. Bischoff H. The mechanism of alpha-glucosidase inhibition in the management of diabetes. Clin. Invest. Med. [Internet]. 1995 Aug [cited 2013 Nov 6];18(4):303–11. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8549017
53. Drira R, Chen S, Sakamoto K. Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells. Life Sci. [Internet]. 2011 Nov 7 [cited 2013 Nov 1];89(19-20):708–16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21945192
54. Ebaid GMX, Seiva FRF, Rocha KKHR, Souza GA, Novelli ELB. Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes. Nutr. J. [Internet]. 2010 Oct 19 [cited 2010 Oct 21];9(1):46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20958965
55. De Bock M, Derraik JGB, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, et al. Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PLoS One [Internet]. 2013 Jan [cited 2013 Nov 1];8(3):e57622. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
56. Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, Kerem Z, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J. Med. Food [Internet]. 2012 Jul [cited 2013 Nov 1];15(7):605–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22512698
57. Kontogianni VG, Charisiadis P, Margianni E, Lamari FN, Gerothanassis IP, Tzakos AG. Olive leaf extracts are a natural source of advanced glycation end product inhibitors. J. Med. Food [Internet]. 2013 Sep [cited 2013 Nov 1];16(9):817–22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24044491
58. Lui T-N, Tsao C-W, Huang S-Y, Chang C-H, Cheng J-T. Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells. Neurosci. Lett. [Internet]. 2010 May 3 [cited 2013 Nov 4];474(3):144–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20298750
59. Chang C-H, Tsao C-W, Huang S-Y, Cheng J-T. Activation of imidazoline I(2B) receptors by guanidine to increase glucose uptake in skeletal muscle of rats. Neurosci. Lett. [Internet]. 2009 Dec 25 [cited 2013 Nov 4];467(2):147–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19822195
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60. Mooney MH, Fogarty S, Stevenson C, Gallagher AM, Palit P, Hawley SA, et al. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br. J. Pharmacol. [Internet]. 2008 Apr [cited 2013 Nov 4];153(8):1669–77. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
61. Palit P, Furman BL, Gray AI. Novel weight-reducing activity of Galega officinalis in mice. J. Pharm. Pharmacol. [Internet]. 1999 Nov [cited 2013 Nov 4];51(11):1313–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10632090
62. Quan H-Y, Yuan H-D, Jung MS, Ko SK, Park YG, Chung SH. Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice. Int. J. Mol. Med. [Internet]. 2012 Jan [cited 2013 Nov 4];29(1):73–80. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21971952
63. Dey L, Xie JT, Wang A, Wu J, Maleckar SA, Yuan CS. Anti-hyperglycemic effects of ginseng: comparison between root and berry. Phytomedicine [Internet]. 2003 Jan [cited 2013 Nov 4];10(6-7):600–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/13678250
64. Xie JT, Zhou YP, Dey L, Attele AS, Wu JA, Gu M, et al. Ginseng berry reduces blood glucose and body weight in db/db mice. Phytomedicine [Internet]. 2002 Apr [cited 2013 Nov 4];9(3):254–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12046868
65. Attele AS, Zhou Y-P, Xie J-T, Wu JA, Zhang L, Dey L, et al. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes [Internet]. 2002 Jun [cited 2013 Nov 4];51(6):1851–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12031973
66. Park E-Y, Kim H-J, Kim Y-K, Park S-U, Choi J-E, Cha J-Y, et al. Increase in Insulin Secretion Induced by Panax ginseng Berry Extracts Contributes to the Amelioration of Hyperglycemia in Streptozotocininduced Diabetic Mice. J. Ginseng Res. [Internet]. 2012 Apr [cited 2013 Nov 4];36(2):153–60. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
67. Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes. Res. [Internet]. 2005 Aug [cited 2013 Nov 4];13(8):1335–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16129715
68. Henderson S, Magu B, Rasmussen C, Lancaster S, Kerksick C, Smith P, et al. Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J. Int. Soc. Sports Nutr. [Internet]. 2005 Jan [cited 2013 Nov 4];2:54–62. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
69. Yao J, Zhi M, Gao X, Hu P, Li C, Yang X. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver. Braz. J. Med. Biol. Res. [Internet]. 2013 Mar 15 [cited 2013 Nov 4];46(3):270–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23532271
70. Zhang Y, Hai J, Cao M, Zhang Y, Pei S, Wang J, et al. Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathway. Int. Immunopharmacol. [Internet]. 2013 Sep 13 [cited 2013 Nov 3];17(3):714–20. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24036369
71. Haddad Y, Vallerand D, Brault A, Haddad PS. Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis. Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Nov 4];2011:nep164. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
72. Wallace S, Vaughn K, Stewart BW, Viswanathan T, Clausen E, Nagarajan S, et al. Milk thistle extracts inhibit the oxidation of low-density lipoprotein (LDL) and subsequent scavenger receptor-dependent monocyte adhesion. J. Agric. Food Chem. [Internet]. 2008 Jun 11 [cited 2013 Nov 4];56(11):3966–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18476698
73. Gaya M, Repetto V, Toneatto J, Anesini C, Piwien-Pilipuk G, Moreno S. Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program. Biochim. Biophys. Acta [Internet]. 2013 Jun [cited 2013 Nov 4];1830(6):3796–806. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23541989
74. Ibarra A, Cases J, Roller M, Chiralt-Boix A, Coussaert A, Ripoll C. Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet. Br. J. Nutr. [Internet]. 2011 Oct [cited 2013 Nov 4];106(8):1182–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21676274
75. Harach T, Aprikian O, Monnard I, Moulin J, Membrez M, Béolor J-C, et al. Rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and liver steatosis in mice fed a high-fat diet. Planta Med. [Internet]. 2010 Apr [cited 2013 Nov 4];76(6):566–71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19918713
76. Romo Vaquero M, Yáñez-Gascón M-J, García Villalba R, Larrosa M, Fromentin E, Ibarra A, et al. Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid. PLoS One [Internet]. 2012 Jan [cited 2013 Nov 4];7(6):e39773. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
77. Wang T, Takikawa Y, Satoh T, Yoshioka Y, Kosaka K, Tatemichi Y, et al. Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice. Hepatol. Res. [Internet]. 2011 Jan [cited 2013 Nov 4];41(1):87–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21199201
78. Takahashi T, Tabuchi T, Tamaki Y, Kosaka K, Takikawa Y, Satoh T. Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism. Biochem. Biophys. Res.
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Flawless Skin Couture - We give you the tools to make you Flawless
Meh...today was a bad day so I posted it early. Knock yourselves out.
Evolutionary Muse - Inspire to Evolve
Flawless Skin Couture - We give you the tools to make you Flawless
Should be done end of next week.
Evolutionary Muse - Inspire to Evolve
Flawless Skin Couture - We give you the tools to make you Flawless
Yay! I can't wait for this. This and Slintensity should be just the ticket I need to keep holiday pounds at bay.)
Building my best body "for me"!
Evolutionary Muse - Inspire to Evolve
Flawless Skin Couture - We give you the tools to make you Flawless
Evolutionary Muse - Inspire to Evolve
Flawless Skin Couture - We give you the tools to make you Flawless
So totally in for this. I have been eagerly waiting for such a long time. I cant wait to run it during my Helladrol cycle. Now all I need to concern myself with is just picking things up and then putting them down lol.
Amazing job
Looking forward to Matt's creation
...::: Olympus Labs Athlete & Representative :::...Crossfit - DEMIGOD -
Interested in this product. Love how you always give great study reads and references that go for days lol.
Black Lion Representative
I'm a Brooklyn boy I may take some gettin' use to
Looking for a replacement to TTA as my PPAR agonist for stim free night time fat loss
...::: Olympus Labs Athlete & Representative :::...Crossfit - DEMIGOD -
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text:
Basis of Presentation
This combined group management report by the SAP Group (collectively, "we," "us," "our," "SAP," "Group," or "Company") and the management report of SAP SE have been prepared in accordance with sections 289, 315, and 315a of the German Commercial Code and German Accounting Standards (GAS) No. 17 and 20. The management report is also a management commentary complying with the International Financial Reporting Standards (IFRS) Practice Statement Management Commentary.
All of the information in this report relates to the situation as at December 31, 2015, or the fiscal year ended on that date, unless otherwise stated.
The report contains references to additional information in other parts of the SAP Integrated Report that is available online. This additional information is not part of the management report.
Forward-Looking Statements
This management report contains forward-looking statements and information based on the beliefs of, and assumptions made by, our management using information currently available to them. Any statements contained in this report that are not historical facts are forward-looking statements as defined in the U.S. Private Securities Litigation Reform Act of 1995. We have based these forward-looking statements on our current expectations, assumptions, and projections about future conditions and events. As a result, our forward-looking statements and information are subject to uncertainties and risks, many of which are beyond our control. If one or more of these uncertainties or risks materializes, or if management's underlying assumptions prove incorrect, our actual results could differ materially from those described in or inferred from our forward-looking statements and information. We describe these risks and uncertainties in the Risk Management and Risks section.
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This course is designed for people that teach Functional Skills and GCSE English within Further Education. It is ideal for teachers who have L2/ GCSE English themselves, but want to improve skills to Level 3. It is a bridging qualification to the L5 Subject Specialism Certificate. This is a part-time attendance based course. The programme is recognised by the Department for Education and Skills and incorporates the 2014 Education and Training (ETF) teacher teaching standards. It is recommended for teachers of Functional Skills and GCSE English.
The course allows a teacher to develop their English Subject Specialism. Although applicants should be aware that all teachers of English are required to gain a full initial teaching qualification (CertEd/PGCE) in addition. The qualification has been developed in response to sector demand for a specific qualification for Functional Skills teachers to be developed. It is of particular value as a bridging programme for Skills for Life (SfL) teachers who are aiming to become Level 5 subject specialists.
The course is specifically designed for teachers of Functional Skills and the qualification is in place to allow SfL specialists to be able to bridge the gap between the Level 2 Functional Skills qualifications and the current Level 5 subject specialist awards. Any teacher of SfL who is looking to be awarded ATLS/QTLS must ultimately hold a Level 5 subject specialism.
This course is suitable for those teachers of English who want a subject specific qualification. Candidates are required to at least hold Level 2/ GCSE English and there must be confidence that an applicant's Literacy Skills are at a standard in order to be able to progress to the study of these skills at Level 3. The qualification is appropriate for people above the age of 19. There is no requirement to be observed doing any practical teaching.
The course is a part-time attendance based programme. Sessions will take place once a week.
During the course the following topics will be covered:
The course is ideal for candidates who wish to progress to subject specific Literacy teacher education programmes. This qualification allows candidates to learn, develop and practise their personal skills in English required for entry to specialist teaching qualifications. The qualification was developed to cover the criteria for entry to mathematics (Literacy) teacher training in the lifelong learning sector.
4 x 2 hour unit tests at the end of each module.
On successful completion of the Level 3 Award in English for Literacy Teaching learners could progress to the Level 5 Subsidiary Diploma in Teaching English (Literacy) in the Lifelong Learning Sector run through the University of Bedfordshire.
This course runs on multiple occasions. Choose the date most appropriate for you and select the 'Enrol' button to book online.
If you need help you can call us on 01234 291000.
To apply online, select the 'Apply' button below. You will need to register an account and then you can follow the instructions on screen.
Is this course right for me? View our qualifications guide.Find out about our fees & financial support.
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第一次接到她的電話 按下通話就霹靂啪拉 連是哪個大學的都沒聽清楚
只知道她要跟我做interview, 溝通障礙下,她只是不斷問我 are you chih-yuan kang? yes!
OK! I will send you an e-mail. see you
Fortunately, UU 的人還蠻有耐心的! 沒有直接刪除我的申請!
過了大約一周後就有一個自稱是UU的MBA sophomore寫信給我,
跟我約面試方便時間,約好了後都一直沒接到他的電話, 因為Utah跟Taiwan時間大約14小時
約好了面試時間,台灣時間星期一到五的晚上8點過後到12點間~ 就開始等待他的電話
Suddenly, I got an e-mail about him, he said
"Your guess is right on the time for what my time would be. You are 14hours ahead of our time. Let's do a 22:30 time, and I'll keep an eye on the time to get us finished by 23:00 your time. Let me know what day would work for you. I live close to school, so you only need to give me a little notice.
Don't worry, I know what you mean about speaking too fast. As I've tried to understand Spanish I deal with that problem often. As a result, I try to speak slow and clear with anyone who is learning English."
Don't worry, I know what you mean about speaking too fast. As I've tried to understand Spanish I deal with that problem often. As a result, I try to speak slow and clear with anyone who is learning English."
當然趕快回信給他嚕~好加在! Chris is so kind and patient~
In Hawaii, we dated again and again. For example, he had to go to school for class and work hard in his studying.
And there remains different time zones in Hawaii and Utah, about 5 hours.
In one day's morning, two days before the deadline, I got his call.
Here are some interview questions below.
1. Tell me about some content of your essay?
2. From essay,Chris find some question, such as why you give up your officer work in army?
3. How do you know about UU andwaht do you feel about MBA program of UU?
4. Did you apply other school?
5. If you find your colleague or your classmate have some problems, what will you do?
6. Do you want to have your own business?
7. Did you have some question about UU?
Chris spoke in a slow pace, like using pictures to tell a story, to make sure every information I got correct.
Why I apply UU?
Without a large business center and with special religion, Salt lake city is not a big city in US, and her population isn't too much.
But I will have my own business in the furture, so without necessary famous diploma, the famous and expensive universities are not considered.
Moreover, saving money becomes an important reason for me because I am not sure that I can get scholarship.
Specially, with the special religion and traditional culture, the people of salt lake city tend to get along with, such as Chris.
It could help my English ability and culture adaption.
UU also has a strong background of industry, perhaps, it may help my Taiwanes networking in the future.
Without discussing about excellent interaction and creative MBA programs, UU already are worth investing.
But my tofel grades and GMAT scores are not enough to enter UU. So I got a letter from them after three days.
Talking that this semester there are too many people applying UU, and they are sorry that I were not in the MBA 2007~2008.
Fortunately, after a week, I got another letter, which give me some infomation that I can apply some other Business programs in UU.
I believe that maybe the first letter was sent before my interview because the general type of letter needs near a week to sent to Taiwan.
Surely, the refusal is stong caused by my poor grades.
I believe I would like to ask some information about UU, because their services are beat my heart!
A successful interaction between client and organization~


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If you are reading this you might have friend or relative or significant other who is of the artistic ilk or temperament. They feel the need to create and are often difficult to deal with. so here are a few friendly words of advice about how to handle your artist
- Occasionally your artist might suffer from a block. Like a clogged drain that wont let water pass your artist is clogged. Somewhere between the brain and hands all the art gets stuck. At best what ends up on paper is a mess. At worst there is nothing at all. Art block is uncomfortable and depressing. Your artist may be grumpy and moody. Consider plying them from their dark moods with sweets and a nice movie.
- Sometimes your artist may seem lost to the world as they work on a thing. When inspiration strikes you have to work fast and catch the lightning strike before it fades. The artist may work tirelessly for hours in the glow of their genius. Try not to interrupt your artist since they may not take it well. If you feel up to it, get them a glass of water or a snack. They might have forgotten such physical needs
- And finally, it may be annoying having every rough sketch shoved under your nose while your artist stands by with puppylike eagerness. But art is meant to be looked at by many eyes and it gratifies your artist greatly to have you look at it. Even if it's a half finished painting that looks like nothing at all. Offer up any praise you can think of. If the work merits criticism then give it. Your artist needs to know how he or she can improve but criticism may hurt so be gentle.
And that is all the wisdom I have to offer you. Go out in the to the world with your artists! They may not have seen the sun for awhile and its good for them to remember a world exists outside their own mind.
Good luck!


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You've heard the ole saying about the cobblers kids going barefoot, because he's too busy making shoes for everyone else......well, I have to admit that I'm guilty of neglecting my immediate family in the quilt arena.
I had good intentions, but good intentions only get you so far.
Here's where it got me......
|He's laughing here because I told him that this was as big as his quilt was going to be.
....an unfinished quilt. On the day of his graduation I was only able to present him with a tiny sample of his quilt. So much for good intentions. At least he was amused by my tiny quilt presentation.
But there is still hope! And after a not so small change at the request of the recipient, progress is being made.
In total I need 361 of these nine-patch blocks.....I have 23 completed
Originally I had cut all 324 (3-1/8") squares from Kona white....this was the change Michael requested, he didn't like all that white and asked if I could change these to black, "Of course I can son, I aim to please!!"
Bring those three pieces together and here's a peak at what you have. It looses the chain affect, but I think it still has a nice look. See the rack in the top, left corner of the pic? those are all the strips waiting to become tiny (3-1/8") nine-patch blocks.
This week I've also added a wedding gown and a bridesmaid dress to my upcoming schedule, I'm going to have to be very intentional and purposeful with every bit of my time from now until mid-September when all three projects must to be finished. I know I'll be busy, but I like being able to work with a purpose!
Be Creative!


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Following our previous post regarding Sonicwall's NAT limitation, 3CX is pleased to announce that a SonicOS update was released which enables clients and partners to use these devices in front of the 3CX Phone System as NAT device. With this change, VoIP Providers and direct remote extensions (STUN) can be connected to the 3CX Phone System and are covered by the 3CX Support team as a supported setup.
Take a look at our updated our Sonicwall configuration guide with detailed instructions to help you configure your Sonicwall device.
DELL Sonicwall reference ID: KB HF152075


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Mention Chris Webber, Don Nelson and the Warriors to anyone who knows hoops and you get a grunt, followed by a slow exhale. And for good reason. If only those directly involved remember the details of the clash between the three-time Coach of the Year and the 1994 Rookie of the Year, everyone knows what it wrought: Golden State's plummet from the cusp of title contention to an 11-yearand-counting playoff drought.
"What I learned is the coach and the star have to be on the same page," says Mavs coach Avery Johnson, a former Golden State point guard. "The star doesn't have to be a yes-man, but he has to be committed to the coach's vision. Without that, it's not going to work."
Johnson's words should resonate around the league-and, no, we're not talking about the Staples Center. The Lakers may be playing with fire, but at least management has a heads-up about Phil and Kobe. The unknown coach/superstar relationships in places like Seattle are the ones that could ignite. Will Ray Allen and Bob Weiss jell? Fans hope so. It's easy to jettison a role player who's not drinking the Kool-Aid, but if a coach and his franchise player are butting heads, well, watch out. Remember the Warriors.
"I learned a house divided can't stand," says Mavs GM Donnie Nelson. "If you have chemistry issues off the floor, it's just a matter of time before they spill onto the floor." Donnie was a Golden State assistant when his father and Webber led the Warriors to a 50-32 record and a playoff berth during the 1993-94 season. While the high-scoring squad was fun-andgames on the floor, a power struggle was unfolding off.
Even before signing him, Nellie told Webber that he'd be playing center. Not surprisingly, the perimeter-oriented rookie wasn't happy. "He wanted to be Magic Johnson," recalls Spurs coach Gregg Popovich, another Nelson assistant at the time. "We wanted him to be more like Karl Malone."
CWebb didn't roll over. Right before the press conference announcing his contract signing- with the media sitting in the next room-Webber told Nelson he wouldn't sign unless he was exempt from the team's business-casual dress code. A compromise was made, but the psychological warfare didn't end. Nellie ridiculed Webber's free throw form in front of reporters during training camp. Webber then leaked that he would exercise his one-year option and not return unless something was done about Nellie. "We heard things from other guys on the team," Donnie says. "But we thought, how bad can it be?"
So bad, actually, that Webber held out until he was dealt in a sign-and-trade to Washington eight games into the 1994-95 season. So bad that Webber and Nelson still won't touch the subject, 11 years later. So bad that it forged the management philosophy of Popovich, Johnson and Chris Mullin, another member of that Warriors team. "You have to jump on top of something," says Mullin, the Warriors GM. "Don't let it fester."
Popovich's father-son rapport with Tim Duncan began with Pop flying down to the Virgin Islands to hang on TD's home turf. Significantly, they didn't talk hoops. "It helped to find out how cool he was," Duncan says.
And before Johnson took over for Nellie in the Big D, he made sure he and Dirk Nowitzki were on the same page. If they weren't, he says, "I would have had to think twice about taking the job."
Better before than after.


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Joãosinho Trinta, the former ballet dancer who reinvented Rio's Carnival, incorporating luxurious elements and extreme creativity to the popular parade, died today. Controversial, he was frequently criticized by traditional sambistas, that felt that his huge, elaborate carnival floats and the use of some extreme resources, like individual flying machines, would hide the talent of dancers and musicians.
These three videos show Joãosinho Trinta at his best, leading escolas de samba Beija-Flor de Nilópolis and Viradouro to multiple Carnival awards. (And sorry – I was very unimpressed by the quality of the footages available on the web.)
1980 – "O sol da meia-noite – uma viagem ao país das maravilhas" (The Midnight sun – travelling to Wonderland). You will see Joãosinho dancing with the community.
1989 – Considered one of the best Carnival parades ever produced, "Ratos e Urubus" (Rats and Vultures) celebrated all the culture that surrounds waste and waste collection (a surprise, considering that Joãosinho Trinta used to say that the population likes luxury. "Only intellectuals like poverty"). Note that the reproduction of the Corcovado had to be hidden because it was forbidden by the Catholic Church, owner of the Christ's statue.
1997 – "Trevas! Luzes! A Explosão do Universo" (Darkness! Lights! The Explosion of the Universe), created for Unidos do Viradouro, a reference to the Big Bang theory.
Read also other posts about Carnival.


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Fix it And Forget It: The Cookbooks Americans Love
Americans just want to cook simply, not treat their food as some kind of special occasion product.
At least that's what you might think if you read yesterday's front page article in the New York Times (Whipping Up a Cookbook Empire with Meatloaf Instead of Sizzle) and look at recent book sales numbers: the "Fix-It and Forget-It" series, published by Good Books has sold more copies than the combined works of the popular Food Network hosts Ina Garten, Giada De Laurentiis and Jamie Oliver.
Written by a Mennonite in Pennsylvania, Phyllis Pellman Good, the spiral-bound books are filled with recipes like ham loaf and cheeseburger soup.
"Most of us still do want to cook for ourselves and eat at home. And yet all of the pressures of our lives militate against that," said Ms. Good's husband, who runs the publishing company with her, which puts out hundreds of titles, the Fix It series being, by far, the most popular, to the tune of 70-90% of their $10 million annual sales.
We say bravo to anything that has Americans cooking in more than eating out. But we also applaud new and innovated approaches to cooking that also pique the interest of both experienced and novice chefs, and books that give us inspiration to explore on our own. We're not sure ham loaf will have that effect.


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Roma coach Fabio Capello believes Juventus could have the game plan to deny Real Madrid their 10th European Cup/Champions League title.
Capello, a former Juve player and Real Madrid coach, says the gameplan of Juve coach Marcello Lippi is the most likely rock on which Real's bid will flounder.
"In theory Real have something over everybody" said Capello. "If only because they have more experience and the habit of playing at certain levels.
"But sometimes that knowledge can help the tension and attention levels fall and give the advantage to the opponents."


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Feb. 25: Cotton Production Seminar, Tennessee Technology Center, Covington, TN. Call Jeff Via, 901-544-0243, or Michelle Rankin, 901-476-0231.
Feb 26: Corn, Soybean and Small Grains Production Seminar, Baker's Community Center, Millington, TN. Call Jeff Via, 901-544-0243, or Michelle Rankin, 901-476-0231.
April 4-5: Texas Cotton Ginners' Association Annual Cotton Trade Show, Lubbock, TX. Call 512-476-8388.
We welcome state, regional and national agricultural events from readers. E-mail: email@example.com; fax: 952-851-4601; or mail to: Events, The Corn And Soybean Digest, 7900 International Dr., Suite 300, Minneapolis, MN 55425.


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From the book A Year of Little Things: 100 Simple Ways to be Happy by Caroline Somp.
A new year before you like a notebook unopened–crisp, empty pages, straight spine, dreams not dreamt yet, magic unknown. Instead of filling the first page with resolutions, how about something juicy and colorful? Rather than what you should do, what do you want? What dreams flutter in your chest? If you dared, how would life make you feel, where would you be? Aim outrageously high, just to see where you'll end up. Add some empty space for the unexpected, let the possibilities find you? Write a list of what you want in your life. What will this year bring you if only you imagine it?
This reminds me of the power of the Mondo Beyondo list. I seriously need to create mine for the year. It is slightly different to think of the year in terms of wants rather than shoulds. There are lots of things I want in my life this year; there are lots of things I want to manifest in my experience in the next 362 days. Putting them out there into the universe is the first step in making them possibilities.
This year, I want
• a writing retreat
• a trip somewhere warm near a beach
• a weekend camping in the mountains
• to take pictures good enough to sell
• to be successful in my job
• to grow our family
• to have 3 months of living expenses in the bank
• to end the year with just one major monthly debt left to pay off
• to teach a writing course
• to expand my circle of friends
• to use my passport
• run a half-marathon
• get pregnant
• look buying a house
I guess I'm really working on my Mondo Beyondo list. I'll do more on that this weekend.
What is on your list of wants for the year? Where would you like to head if only you could?


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It feels like it's been a long week. Things have been ok. Still working on my graduate applications. Checking the post and the old inbox hoping to hear that I've been selected for an interview. I am thinking that I am going to have to come up with some sort of interim strategy for what the heck I am going to do with my time. These schemes don't start until next year, so if I do get accepted I've got some time on my hands before I start. I think if that were to happen I would get a job, take a class or two, do some volunteering. I could definitely make good use of that time. That's if I get accepted onto a scheme. If I don't then it's back to looking for a job.
I applied at a shop this past Monday and I haven't heard back from them either, which is a tiny bit depressing. Well I am going to get back to my applications. I wish I was working at the Spyhouse today in Minneapolis.


text: You know the name. Now Swiss Gear by Wenger bags is bringing the durability and craftsmanship of the legendary Swiss Army knife to luggage. No, they don't come with fold-out can openers, but thoughtful details on Swiss Gear luggage ---like detachable wet/dry packs and aircraft-grade aluminum handles--- help ensure you'll be ready for anything, just like you would be with a great knife. Swiss Gear backpacks come loaded with features, including laptop compartments and organizer panels. Some backpacks are even TSA-friendly, to help you speed through security check points at the airport.


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Welcome! This is where I will be posting my progress on various craft projects that I have going.
It started as just cross stitch but I seem to be unable to limit myself to one craft.
I got my hair cut a couple of weeks ago. And I can't seem to get this pic uploaded in the right orientation.
Post a Comment


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Some highlights
1 Chelsea Berry returns to the Circle of Friends Coffeehouse in Franklin on Saturday, Feb. 10.
2 Berry appeared in Franklin last spring performing with singer-songwriter Livingston Taylor and she was so impressive that she was invited back as a featured performer. She is a singer-songwriter with the edge, power, and finesse of legends.�
3 As a vocalist and performer, Berry is said to evoke the style of artists such as Cheryl Crow, Eva Cassidy, KD Lang, and Melissa Etheridge.
4 Taylor calls her vocals �world class� and says of Berry, �A voice of remarkable power and control with a joyous soul. Brave and bright, Chelsea Berry is the real thing.�
5 Berry�s voice and stage presence has brought her across the U.S. as regular support for Livingston and others, as well as a headliner of her own shows. Born and raised in Alaska, she now makes her home in New York City.
6 To learn more about Berry, visit http://www.chelseaberry.com/
7 Opening the show will be Billy Keane, a folk musician for a new generation. His music combines story telling and socially relevant lyrical poetry with melodies and accompaniments. Read more about him at http://www.therealbillykeane.com/
At a Glance
WHAT: Chelsea Berry concert
WHEN: Saturday, Feb. 10
TIME: 8 p.m.
WHERE: Circle of Friends Coffeehouse, First Universalist Society Meetinghouse, 262 Chestnut St., Franklin
MORE INFORMATION: Call 508-528-2541 or visit http://www.circlefolk.org/ to purchase tickets or for more information. Doors open at 7:30 p.m. Beverages and gourmet desserts will be available.
HOW TO SUBMIT YOUR EVENT: Follow the format above and send in your event for a TO DO feature. Items should be up to 550 words; a color photo is also required for page 1 placement, which is on a first-come, first-served basis. For questions, or to submit, email firstname.lastname@example.com. Or call 508-634-7584.


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BlackHole Vu + UNO 1.6.6 Backup @ isayuksel (MeoBoot attached) Installation and initial settings:: First, download the latest version of the new image to usb cihaz?m?za install all USB Uno Vu + how images will be scored? (Directory) After installation to be done after the installation settings:: (2) Vu + Duo initial setup settings Quote: Seçilidi HDMI. 1080i is selected. Language Turkish is selected. DHCP on the network. Where You can call this channel channel list or we can install ready. If you want to call channel tuner settings before you have to do. To search for detailed information about the channel: (4) Vu + Duo channel search and bookmark create We check the network settings using. Menu> Setup> System> Network section of the "Network hardware settings" kumandam?z?n come on "OK" button is pressed. Under the section for the current settings to take note of the IP address. (Channel settings will need to install me in the value of the rope.) If the link I gave on the network setup problem can examine this topic: Vu + wired / wireless network setup and test procedure Now we can install Settingimizi Channel: 4 different methods to throw the Channel List (Contacts). Quote: VU + Plus HDTV Channel Setting on the setting of the current channel is loaded. (November 14, 2011 4 Satellite: Turksat, Hotbird, Astra EutelsatW3 and 19.2) @ Galaxy2002 Channel setting is sure to reboot after installing the device. Menu> Setup> Satellite Configuration> Settings section came Tuner Tuner configuration. Quote: A tuner: (Simple) DiSEq A / B / C / D: 42 ° / 13 / ° 7 ° / 19.2 ° Note: You will notice after installing the first channel tuner ayarlam?z? have made our list. Thus, because of the possible names of different satellites, satellite broadcasts, which may be taken in setting, we have prevented errors. Add-on (plugin) installs are doing: Menu => Add-ons come to the section Kumandam?z?n Red button (Add-ons) is pressed. Updating the software catalog for a while after their stay at the screen a message that the system will be a list of plugins into categories. When you press the OK button on your remote control, point to the categories of any plug-ins will be listed in that category. Here you set up off olanalar ekelentilerdir installed. You want to install (or you want to remove), add-ons by checking the set up here (or remove). Quote: Add-on manager; PermanentClock under the System category, Setpasswd under the System category (the password is assigned), StartUpService under the System category (Channel D), TempFanControl under the System category, VlcPlayer under the Software category, SimpleRSS under the category of Multi-media (not active), VirtualZap under the category of Multi-media (press and hold the arrow key), Multi-media category was established under the Weatheer Plugin. VideoTune removed under the category of image management Install (or uninstall) after the end of the process to restart istemed?imiz tamamaland??? and a window will pop up on the question. "Yes" by pressing the OK button on the Kumandam?z?n while providing our device to restart. In line with our desire to do other simple config for: Quote: Menu> Setup> System> Audio / Video settings 4:3 content is as follows: Just Scale > 16:9 content is as follows: Just after the green key to Scale (OK) acknowledge. Menu> Setup> System> Time Zone: (GMT +02:00) Athens, Istanbul, Minsk After setting up the Green Key (OK) We acknowledge with. Menu> Setup> System> Customize section of the user's experience as an expert in changing the Green Key (OK) We acknowledge with. Determination of the initial channel: Quote: Channel List, while the point of the channel you want to begin the startup. Press the Menu key. The drop-down options, press the OK button on your remote control set-point as the stratup service. When you restart your device to open the channel you want. If you want to cancel this process so if you want the latest on what channel you turned off the opening of the channel; While the Channel List, press the Menu key. Service options in the drop-down option on startup, reset, press the OK button on your remote control to come. Quote: set as the startup service: Channel D We can install some plugins that are not BH Panel Addons Manager add-on manager. For this purpose; Press the green and yellow, respectively Kumandam?z?n BH Addons Manager and select the rear panel, we come back. Here, while the kumandam?z?n Addons Download Manager by pressing OK on the pop-up is in Chapter Black Hole Image Plugins can be loaded by pressing the OK button on the plug-ins arrive kumandam?z?n. While we want to establish a plug-in on this too, and then the OK button is pressed kumandam?z?n. Brief explanations about the plugin will display the info. Here, the green button (Download) to whether we want to do with the download and installation information about the problem bu?lundu?u kumandam?z?n on the screen, yes, press OK to carry out the installation. Quote: DreamExplorer 7.3, Sherlock 5.0, WebMedia was v4.0. As described above, you can install the Apple Trailer v1.0 addons Mangere. This extension is not Backupta. Must have on your hdd for this extension to work. During the installation of the folders is the hdd. This causes the addons panel or the / tmp directory needs to be established. Whenever you install plugins as external. Ipk file via ftp / tmp directory on your remote control before you roll the green, then yellow and then drop-down menu, press the "Manual Install Ipk packges" on your remote control, point to the "OK" button. You will see that you want to install the ipk file. Kumandam?z?n was selected even though the "OK" button you can install. Quote: 05.11.2011_mipsel.ipk turkuazpanel_0.3-founded. Quote: enigma2-plugin-extensions-subtitleplayer_3.05_mipsel.ipk file was downloaded and Quote: file was edited on nStreamPlayer. @ Dursundursun Quote: ShowClock established. exit, press the key long-term. Quote: enigma2-plugin-systemplugins-bouquetsprotection_0.1_all.ipk established Quote: enigma2-plugin-extensions-pauli_7.1_all.ipk established. Quote: enigma2-plugin-extensions-enhancedmoviecenter_3.0.0_all.ipk established. Quote: tunisiasat-addons-manager_3.0 was downloaded. Our device after restarting; Quote: Menu => Plugins => tunisiasat manager_3.0 e-addons-plugins-come first under the sport livefootball (3.4b) under the Plugins-multimedia "Netradioturk_2.6-b" Plugins-Glass was established under the Cccaminfo svn3385-r0 Emu are doing the installation: E2_CCcam_2.2.1_bh.tgz download file such as / tmp folder, send the bottom. Black Hole in the Addons Manager (This section kumandam?z?n green and yellow to highlight the key is pressed), pointing to the Manual Install Bh packges kumandam?z?n We press the OK button. While on our file by pressing the OK button again kumandam?z?n and yes also on the menu, and select OK u?una do the installation. CCcam.cfg file / etc folder is located under the. Server uses this knowledge to the file server need not to enter. CCcam.cfg enter a file server E2_Mgcamd_138_bh.tgz download file such as / tmp folder, send the bottom. Black Hole in the Addons Manager (This section kumandam?z?n green and yellow to highlight the key is pressed), pointing to the Manual Install Bh packges kumandam?z?n We press the OK button. While on our file by pressing the OK button again kumandam?z?n and yes also on the menu, and select OK u?una do the installation. N, O, and key update installer we also deal with the establishment of: Hacksat-k e y-downloader-e2_1.1-30102010_mipsel.ipk file via ftp download / tmp folder after sending telnette; Code: Export MALLOC_CHECK_ = 0 ipkg install-force-overwrite / tmp / Hacksat * give the command. If the installation fails again, try to give the following command: Code: ipkg update Once installed, the update of k ey are doing. Kurulumlar?m?z? our config and do the other. If you want to install the skin on your remote control before you press the green and then yellow. Black Hole Addons Manager> Addons Download Manager> Skins section of Black Hole E2 image can come in different skins. I gave the following link if you want to change the threads by taking advantage of funding bootlogo and radio: Vu + bootlogo replacement program, use of ready-bootlogolar ... Quote: Radio fund changed, @ isayuksel If you want to download picon file. Current HD Picon Turksat-W3 (Licher Pils +) Download a copy of the subject picon. Remove the folder or folders that you downloaded zipten / usr/share/enigma2 / picon folder if you have placed in the directory, or create picon folder named after the file permission 755 should be submitted within this folder. Settings and add-ons installed, then take the backup: VU + 'ta Duo & Solo USB and backup at NFI After the installation can review the bookmarked links to the following: Black Hole's acclaimed Mount USB HDD & Operations Note: To use all the features of the image BlackHole flasha need to be installed. Easy come. Enjoy ...
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1. Fridays over in these parts have become baking days. Last week I was craving chocolate like mad and so I whipped up some chocolate frosting and decided I might as well bake a cake to go with it. It's annoying when that time of the month coincides with a race but at least there's chocolate to make everything better ;)
Cake Gremlin agrees
2. My friend Natalie made some incredible carrot-zucchini cupcakes with vanilla rum frosting for dessert last night. Soooo tasty.
These little babies inspired me to make a cake with some bananas that needed to be used. And then I added in some other produce that had to be gone today including a zucchini, a very ripe peach and the end of a bag of shredded carrots. Basically a banana carrot cake with boozy cream cheese icing. But there's also some whole wheat flour, almond flour and the kitchen sink.
YUM! Moist and delicious!!! Thanks Nat! BTW Nat also makes her version of a ratatouille that she calls Natatouille, ha. I'll try to wrestle this super tasty recipe from her.
3. I've been thinking about training a lot lately. I had planned to run the Pasadena full marathon in May but I just don't think it's possible. I'd need to build up my mileage so much in the next few weeks I just don't think it would be any fun. And if it's not fun I don't want to waste my precious time. My plan now is to gradually up my mileage, do more trail running and reevaluate where I am in July to see if doing the Bulldog 50k is in the cards. There's always the 25k and I have years ahead of me for long races.
4. I just sent out the invitations for Little Man's 2nd birthday party. 2 years old!!! Whoa! Music Man really wanted an easy party. We had agreed upon the theme being 'Birthday Party'. Remember when the party was the theme and you just had friends over with cake and balloons? I don't. Ha. But I appreciate the simplicity of it. But then when we were looking the the Evite designs we found a Lego brick theme one and both Music Man and I immediately decided we had to do Lego/ building brick theme. It's a natural choice since it's one of Little Man's favorite activities.
I still want to keep it simple but here ius what I have so far:
Cake: Building Blocks Cake
Activity: We have a trampoline, water table, sand box and slide/climber thing but I was also thinking of putting out a huge blanket with a big box of Mega Bloks we have so the kids can play there too. 2 year olds can't really do directed activities yet
Snacks: lego sandwiches- pbj, and jelly & cream cheese for kids
small regular sandwiches for adults
mango, strawberry, melon kabobs
chips, veggies, dip, guac, hummus
I don't want to do a bunch of candy but maybe some m&m's or lego fruit snacks
and maybe some lego pops for fun- maybe I could do it healthier with fruit?
Decor and favors: lego plates and cups from party city or there's also these which could be cool
I also like the lego wristbands and crayons for favors
Balloons: dot balloons
I'll let you know what we choose. So fun!!!
5. Saw Hunger Games and thought it was pretty fun. It was definitely aimed for a younger crowd but was still entertaining. I do have to say I found the book to have more depth and more suspense. There were some really cheesy moments in the movie that weren't depicted that way in the book. But it gets a thumbs up from me.


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GLENDALE — The following are odds and ends from the local sports scene.
Rookie boxer Artur "The Punisher" Bernetsyan will look to close out his impressive initial pro campaign when he headlines the "Battle in the Ballroom" at the Irvine Marriott Grand Ballroom on Thursday.
Bernetsyan will take on Los Angeles' Demetrio Soto in the six-bout hybrid card's six-round, junior welterweight main event.
Bernetsyan, an Armenian native who resides in Glendale, is 5-0 with a pair of knockouts, all five of his fights coming in this year. He's coming off perhaps his toughest fight to date, a six-round unanimous decision win against Rynell Griffin in Las Vegas in October.


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Fibre types:
Different fibres and fabric styles for different applications.
Para aramid for bullet proof vests - lightness and flexibility for personal protection vests provide high level of comfort.
Para aramid for military helmets - lightweight, good ballistic performance gives optimum protection.
S-2 glass - Lower cost, laminated panels for vehicle ballistic protection at similar weight to para aramid.
E glass - low cost laminated panels for bank panels or shipboard protection where weight is not a consideration.
Joint development policy:
Colan Products is continuously developing ballistic systems for specific applications.
Colan weaves the fabric, make the test panels and carry out shooting tests, all in Australia, to match the ballistic properties to those required.
Colan works in a partnership arrangement to help customers obtain an ideal product with maximised Australian content.
- Bullet proof vests
- Military helmets
- Military fragmentation vests
- Spall liners for military vehicles and ships
- Protection of ship board ordnance magazines
Bullet proof panels for:
- Military vehicles
- Aircraft
- Ships
- Money carrying vehicles
- VIP vehicles
- Banks or money handling premises
Recent projects using Colan ballistic systems:
- Combat helmets for Australian army
- Fragmentation vests for Australian Air Force
- Spall liners for M113 personnel carriers
- Fragmentation vests for Australian Army
- Protection of ordnance magazine on Huon class Minehunters. Colan also supplied the woven fibreglass from which the hulls were fabricated
- Bullet proof vests which are both tactical and covert to Police Services in Australia and overseas.


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Now Viewing:
Product Highlights
The Raxxess Space Economy Rack with 20 Spaces, Model ER-20 (Black Oak) is a simple and sweet design that is perfect for your gear. More than 5/8" medium-density fiberboard is covered with black oak laminate for an attractive finish that will match your existing equipment and racks. This is an affordable solution to any media center.
|5/8" medium-density fiberboard
|Black Oak laminate
|Fully portable (Casters optional)
|Dimensions (WxHxD)
|20.5 x 36.8 x 15.75" (52 x 93.9 x 40cm)
|Weight Capacity
|Not Specified by Manufacturer
|Not Specified by Manufacturer
|Packaging Infoyuxdvyrvfbfrwxuaydeswtetaubfxfez
|Package Weight
|37.5 lb
|Box Dimensions (LxWxH)
|39.0 x 18.0 x 5.0"