text:
View from Above
"But what has Barack Obama accomplished that entitles him to look down on his fellow Americans?"
Some cogent analysis by Kristol, in (of all places!) the New York Times...
It is very easy for persons of good will to 'give Obama the benefit of the doubt', and that IS a reasonable choice.
For ONE or, over a few months, TWO, mistrakes or mis-speaks or Hoofin-Mowf Disease symptoms...
With this San Francisco-billionaires revelation, however, persons of good will now have a PATTERN of racist, elitist disclosures indicating a deep, chronic and seriously infected human in Obama's case. One slip can be rationalized, but three or more ("typical white persons", "racist grandmother", "Reverend Wright is just fine" and now "bitter hillbillies") is prima facie evidence of SOME UNDERLYING PROBLEM which will NOT YIELD to rationalization.
These 'mis-speaks' are NOT 'mistakes', but THE HONEST REALITY of Obama. It is the feel-good 'hope' and 'change' and 'we can work together' that are false, obfuscating, MASKING and DIVERTING statements designed to cover up Obama's racist, Marxist agenda.
/photo: Obama's paternal grandmother, at her luxurious, Obama-financed ranch home in Kenya.


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This antique Scottish agate, sterling silver bracelet is a rare work of art. Scottish jewelry has a unique beauty with world wide collectors. It became extremely popular when Queen Victoria visited her beloved Balmoral Castle, dressed her children in tartans and adorned herself in Scottish jewelry. Most Scottish jewelry has traditional forms worn by the men, but bracelets and some sentimental brooches were designed specifically for the women.
This particular bracelet reflects many days of labor and requires the skill of a master lapidary. Each agate is cut and placed next to another like a fine checkerboard puzzle and then set on slate. The alternate sections are curved with the center agate curved and fitted to the others. The colors are subtle and beautiful with all agates indigenous to Scotland.
The bracelet terminates with a padlock, finely hand engraved with four agates fitted to the center. The reverse has a locket with hair beneath a glass, a sentimental token of love preserved through time.
It measures 7 1/2 inches long X 7/8ths inches wide. The bracelet is in excellent condition and is completely original. Unique in its choice of agates and in its fine rendering.
Scotland, circa 1860.
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I am a person loving, Submissive, flirtatious, I like to read, get to know new places, experience new things, exercise, dance and have a hot and very sexy chat.
I am a woman able to tackle new scenarios, situations and varied that they develop and enable the physical attraction and sensual fantasies.
oral sex, try different positions and dance
I like respectful, loving, people skilled for Petting, good oral sex, be imaginative, achieve the pleasure in my. Spiritual, loyal, and passionate.
The traditional routine, a man with troubles, unpleasant at the moment of speaking and that smells ugly.
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Vigo 4 oz. Mussels In Marinade
Vigo Mussels in Escabeche have been a longtime favorite in our expanding line of Spanish Seafood products. Archaeological findings indicate that mussels have been used as a food for thousands of years. Still popular today mussels are known for their delicious, slightly sweet flavor. Our plump, juicy mussels are marinated in a sauce of oil, vinegar, red pepper and spices. Enjoy them as part of a seafood antipasto tray or as a healthy lunchtime treat.
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- Country of Origin: Spain
- Packed in: Spain
- Best By Date/Location: MMM DD YYYY; On the side of the box
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text: There will be a Lodge Leadership Development Conference held at Camp Ho Non Wah the weekend of August 17-19th. All lodge officers, committee chairmen, advisors, chapter chiefs, Dixie 2013 Chairman and advisors are encouraged to attend. There will be no cost for the weekend, but please email the chief to let him know that you are attending.


text:
Architect Scott Ballard designed and built his own home—then six others on his street
Sign up for The Intelligencer, a bi-weekly dose of design inspiration, interviews, contests and more, sent directly to your inbox.
Design Bureau delivers honest and inspirational global dialogue on design from diverse disciplines and points of view. It gathers people like you—creative professionals, style arbiters and industry leaders—and connects you with a like-minded community of design enthusiasts across the world with one common idea: discovering great design and the people who make it happen. Published in Chicago by ALARM Press.


text:
At 16 I met the the best photography tutor in the world, Richard Peregrine. Studied still life at Blackpool College and at 21 embarked on my photography life in London.
Assisted everyone from dodgy porn photographers to Terry O'Neil, Terrance Donovan and George Logan.
A massive motorbike accident brought an abrupt end to my assisting career but forced me to eventually go on my own. In 1997 I met Simon Difford who was launching a drinks magazine called CLASS. (Cocktails Liquors and Speciality Spirits!) It was a spirits based magazine and way before it's time.... and it kick-started the cocktail culture we know today. A few issues in and I realised I'd found my niche, as I loved the drinks industry and I quickly became known as "that guy who shoots cocktails".
It's nearly 2 decades later and I still love the way different liquids can look with alternative lighting techniques - I can't imagine I'll ever stop experimenting.
I owe it to my wife and three children that I've managed to keep on the straight and narrow with all that liquor around...!
- Martini
- Johnnie Walker
- Drambuie
- Gordons Gin
- Martini
- Balvenie
- Schweppes
- Pernod Ricard
- Guinness
- Jack Daniels
- Haig
- Greenalls Gin
- Hennessy
- Gallo
- Remy Martin
- Ketel One
- Baileys
- Castello
- Waitrose
- Tanqueray
- Plymouth Gin
- Peroni
- Time Out
- Ciroc
- Kraken
- Bloom
- Grey Goose
- Lurpak
- Hendricks Gin
- Monkey Shoulder
- Chivas
- The Glenlivet
- Laurent Perrier
- Diageo trade
- Haagen Dazs
- Absolut
- Berkley Hotel
- Castello
- Mr Black
- Proximo


text:
CURRENT MUSIC: Beethoven's 5th Symphony
Hello again.
I have asked Captain Jones to explain Blogging to me. She obliged. I now understand that this format is not like the crew logs on our ship, where I detail missions and security specs. Nor will it be like our ship's computer. The computer speaks back to me. Captain Jones has said that Blogs do not talk back. She mentioned that sometimes there are Commentors. I am unclear on the concept, but will meet these Commentors as I always do: with the heart of a giant and the iron grin of a warrior.
Instead, a Blog is a diary. It is a place for me to share my thoughts. Captain Jones said this would be good for me.
|Captain Jones
So. Dear Diary,
I should not be here.
I should have been executed at the SyzyCourts on Barfugrab.
I should have died an unknown.
Fate, however, was on my side. Captain Jones insists that what I call fate is actually her ineptitude. No matter. She crashed into my life when it was about to be snuffed out. She says I could have saved myself.
Not without her.
Diary, I have never been so indebted to another!
Not only has she saved my life, she showed me how to blog!
Though I must admit that I am unused to being so forthcoming about my internal life. There is so much I've had to keep secret. Like All the Killing.
Should I not have spoken of All the Killing?
I have been told I give people the wrong impression when I talk about All the Killing. Perhaps I should Blog on lighter matters? Perhaps I should Blog on the movie How to Lose a Millocanth in 10 Parsecs. I have been told it is an enjoyable film that I "OMG MUST WATCH."


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INDIANAPOLIS — The Lakers hit the road Tuesday and began the season's longest trip, a 10-day excursion during which they will play five games, starting tonight against the resurgent Indiana Pacers.
The Lakers are 39-13, and Coach Pat Riley said that any after-effects of Sunday's 105-99 loss to the Celtics should be gone.
"That game is filed away now," Riley said. "It's history. Maybe it will even do us some good."
The Lakers may find out if Riley is right on this trip, which will continue Friday night against the New Jersey Nets and also includes games Sunday afternoon at Philadelphia, Monday night at Atlanta and Wednesday night at Dallas.


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Inner ear's energy can work like a battery, can power tiny devices .
For the first time, an electrical device has been powered by the ear alone. The team behind he technology used a natural electrochemical gradient in cells with the inner ear of a guinea pig to power a wireless transmitter for u to five hours. The technique could one day provide an autonomous power source to the brain and cochlear implants, says Tina Stankovic, an auditory neuroscientist at Harvard University Medical School in Boston, Massachusetts.
Nerve cells use the movement of positively charged sodium and potassium ion across a membrane to create an electrochemical gradient that drives neural signals. SOme cells in the cochlear have the same kind of gradient, which is used to convert the mechanical force of the vibrating eardrum into electrical signals that brain can understand.
Tiny Voltage
A major challenge in tapping such electrical potential is that the voltage created is tiny – a fraction of that generated by a standard AA battery. Now, Stankovic and her colleagues have developed an electronic chip containing several tiny, low resistance electrodes that can harness a small amount of this electrical activity without damaging hearing. The implant was inserted into a guinea pig's inner ear and the electrodes attached to both sides of cochlear cell membranes. Attached to the chip was a low power radio transmitter.
Guinea Pig
The device needed kick-starting with a short burst of radio waves, but was then able to use the electrical gradient running across the membrane to sustain the transmitter for up to five hours. Tests showed that the guinea pig's hearing was not affected.The device works well for short durations but long-term use of the electrodes risks damaging the sensitive tissue inside the ear. The next step will be to make the electrodes even smaller, reducing their invasiveness.


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Luanda, Angola (PANA) - At least 79.9 percent of people living in Angola have heard about HIV/AIDS, though only 23 percent know enough about HIV/AIDS prevention, Angola's Press Agency (ANGOP) said Thursday.
The state-run news agency quoted a report released by the National Statistics Institute (INE) as showing thatat least 84 percent of women aged 15 to 49 years old and 86% of people aged 15 to 24 years are aware of the disease.
However, among people under 15 years old and above 49, the level of awareness is only 50-60%.
Overall, less number of women (77%) know about the disease than men (83%).
-0- PANA SEG 8Sept2011


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Format: Large Format135 Format Large Format Medium Format
A dedicated booklet for recording all of the pertinent data when working with film, this Analogbook Large Format Notebook is a sleek means for noting and organizing exposure and shooting information. Created for photographers working with large format sheet film, this customized 64-page notebook contains 60 sheets worth of templates for jotting shooting data sheet-by-sheet. In addition to the templated pages, the notebook also includes several pages of blank paper for making additional notes, drawings, or diagrams, and the interior covers are lined with useful photographic tips, charts, and tables for easy reference.
The notebook's 3.8 x 5.5" dimensions make it a convenient size for carrying in your pocket or camera bag, or storing in 4 x 5" film archival sleeves for safe storage. Each booklet is printed using vegetable-based inks on 100% recycled paper, and the back cover serves double-duty as an 18% reflectance gray card for exposure metering.
Vegetable-based inks on 100% recycled paper
18% reflectance gray back cover
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Seared Ahi, such a fine treat, usually reserved for Asian restaurants, but why? It really doesn't take a lot of work, or ingredients to make this delicious appetizer at home, and add in your own flare.
I have lost count of the number of these I've cooked in my past restaurant jobs, but it's still a personal favorite, especially when Ahi goes on sale. It's also a great dish to pull out if you're really trying to impress a guest, or just want to liven up the humdrum weeknight dinner. In full disclosure, in the restauraunts, I was using a prepackaged spice blend, that I've not quite recreated, and also haven't really seen for sale, but that doesn't mean we can't get close, or even better, doing it at home.
- Sesame Oil
- 1 tsp cayenne pepper
- 1 tsp course sea salt
- 1 tsp course ground pepper
- pinch of ground ginger
- pinch of brown sugar
- 1 tsp Chinese 5 spice, if you have it
- Get a cast iron pan on heat, with enough sesame oil to cover the bottom, it really depends on the pan how much you will need.
- Dry the tuna on papertowels, while drying, combine spices on a plate.
- Coat the tuna with the spice mix, however is easiest for you. I put in down and just roll it around on the spices.
- When properly coated, begin to sear. Depending on thickness, about 60 seconds a side.
- Make sure you sear top, bottom, and as many edges as you can. tuna cooking
- Slice with a SHARP knife. My knife wasn't as sharp as I thought, resulting in thicker slices and rough edges. You're looking for 1/4 inch thick or thinner, preferably thinner.
- Serve over greens, or on its own. I like to dip in Thai Chili Sauce, in the restaraunt we served with Ponzu, but I personally dislike the taste. Teriyaki is good, but so is just straight.
- If your oil looks like this image, you messed up. This was from my first home attempt, it was way over salted, and way over cooked.
Old Bay may sound like a good idea as a spice to add. It's not. Way to much salt for the dish to come out right.
- I've used lemonpepper in my spice mix with mixed results, some people like it, some don't.


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Journal of the American College of Cardiology
Effects of bradykinin on coronary blood flow and vasomotion in transplant patients
Author + information
- Received December 31, 1998
- Revision received November 24, 1999
- Accepted January 13, 2000
- Published online May 1, 2000.
Author Information
- Eduardo Aptecar, MD∗,†,* (eaptecar{at}club-inernet.fr),
- Emmanuel Teiger, MD∗,†,
- Patrick Dupouy, MD∗,†,
- Christophe Benvenuti, MD‡,
- Morton J Kern, MD§,
- Javier Woscoboinik, MD†,
- Said Sediame, MD†,
- Jean Marc Pernes, MD†,
- Alain Castaigne, MD∗,
- Daniel Loisance, MD‡ and
- Jean-Luc Dubois-Randé, MD∗
- ↵*Reprint requests and correspondence:
Dr. Eduardo Aptecar, Fédération de Cardiologie, Service du Pr A Castaigne, Hôpital Henri Mondor, 51 Av du Maréchal de Lattre de Tassigny, 94010 Créteil, France
To evaluate the effects of exogenous bradykinin on coronary epicardial and microcirculatory tone in transplant patients (HTXs), and to compare them with the effects of acetylcholine.
Coronary endothelial dysfunction has been reported to occur early after heart transplantation, most notably when acetylcholine was the endothelium-function marker used. The effects of bradykinin on coronary vasomotion are unknown in HTXs.
Sixteen HTXs were compared 3.6 ± 1.7 months after transplantation to seven control subjects. Coronary flow velocity was measured using guide-wire Doppler. Diameters (D) of three segments of the left coronary artery and coronary blood flow (CBF) were assessed at baseline, after 3-min infusions of increasing bradykinin doses (50, 150 and 250 ng/min) then of increasing acetylcholine doses (estimated blood concentrations of 10-8, 10-7 and 10-6 M).
Bradykinin induced similar dose-dependent increases in D and CBF in both groups: D was 11 ± 12%, 19 ± 14% and 22 ± 16% (all p < 0.0001), and CBF was 50 ± 40%, 130 ± 68% and 186 ± 77% (all p < 0.0001). Acetylcholine induced significant epicardial vasodilation in control subjects and vasoconstriction in HTX, as well as a marked increase in CBF in both groups. Acute allograft rejection, present in 8 of the 16 HTXs, did not modify responses to bradykinin, but was associated with a smaller CBF increase in response to acetylcholine (p < 0.05).
The coronary vasodilating effects of bradykinin are preserved early after heart transplantation, even in the presence of acute allograft rejection. Although there is an abnormal vasoconstricting response to acetylcholine reflecting endothelium dysfunction, the endothelium remains a functionally active organ in heart transplant recipients.
Coronary endothelial dysfunction has been shown to occur early after surgery in heart transplant patients, before the development of graft atherosclerosis detectable by angiography (1–3). Several potentially injuring factors present starting at the time of heart explantation may explain the impaired endothelium-mediated vasodilating responses, most notably in response to acetylcholine, reported as early as one month after transplantation (4). However, although an abnormal response to acetylcholine is a hallmark of impaired endothelial function (5), normal coronary vasomotor responses in transplants have been found in studies using other pharmacological (6,7) and nonpharmacological tests (8,9).
Bradykinin is an endogenous vasoactive substance involved in a wide range of biological processes (10). Bradykinin is a potent endothelial-dependent vasodilator, whose effects are mediated through the nitric oxide and prostacyclin pathways, and probably also through an endothelium-derived hyperpolarizing factor (EDHF), as shown by in vitro and animal model experiments (11–15). Few data exist on the effects of bradykinin on the human coronary circulation. Kuga et al. (16) showed for the first time that intracoronary administration of bradykinin dilates normal human epicardial coronary arteries in vivo. In contrast, in the same study, bradykinin-induced vasodilation was impaired in atheromatous stenotic segments. The effects of bradykinin on the coronary circulation of transplanted hearts are unknown.
The aim of this study was to assess the effects of exogenous bradykinin on coronary blood flow and vasomotion in heart transplant patients, and to compare them with the response to acetylcholine. Results in transplant recipients were compared with those in a control group.
Patient selection
Control subjects
Seven young adults were selected as control subjects (group 1, controls). They were referred for diagnostic coronary arteriography because of repetitive atypical chest pain with equivocal bicycle exercise test and/or thallium scan findings. All were found to have angiographically normal coronary arteries without lumen irregularities. They were normotensive and free of diabetes mellitus and hypercholesterolemia. All had normal left ventricular systolic function as assessed using two-dimensional and M-mode echocardiography (Table 1), and none had echocardiography evidence of cardiac hypertrophy according to American Society of Echocardiography criteria (diastolic septal and posterior wall thickness less than 10 mm, measured at end-diastole). At the time of the investigations, none of the controls were on cardiovascular drugs, and four were taking aspirin on a regular basis.
Heart transplant recipients
Sixteen heart transplant patients were included in the study (group 2, HTXs), 3.6 ± 1.7 months after the transplant procedure. All had angiographically normal coronary arteries, without luminal stenoses or irregularities, as judged by two experienced observers. All had normal left ventricular two-dimensional and M-mode echocardiography parameters (Table 1). Posttransplantation immunosuppressive therapy included prednisone and cyclosporine in all patients, and azathioprine in 10. Cyclosporine was titrated to maintain serum levels between 150 and 200 ng/mL, as measured by nonspecific radioimmunoassay (Sandoz). Right ventricular endomyocardial biopsy was performed on the day of the investigation. Potential risk factors for graft vasculopathy evaluated during the study included recipient age, donor age, number of previous rejection episodes, incidence of hypertension and diabetes, lipid profile and cytomegalovirus infection.
Study protocol was approved by the local Ethical Committee. Informed consent was obtained from each patient.
Study protocol
All patients fasted for at least 12 h before the investigation. Vasoactive drugs including calcium channel blockers, beta-adrenoreceptor antagonists, alpha-adrenoreceptor antagonists and angiotensin-converting enzyme inhibitors were discontinued 24 h before catheterization. None of the HTXs were on aspirin. No premedication was administered. One percent lidocaine was used for local anesthesia, and 5,000 U heparin was administered intravenously at the time of percutaneous femoral cannulation. After completion of diagnostic right and left heart catheterization, an additional 5,000-U heparin dose was given. A 7.0 F guide catheter was positioned in the left main coronary artery. A 6.0 F bipolar pacing wire was placed in the right ventricle through the femoral vein. A 0.014-in. tip guide wire Doppler (FLOWIRE, 12 MHz; Cardiometrics, Inc., Mountain View, California) was advanced through the guiding catheter into the proximal segment of the left anterior descending coronary artery distal to any large branch.
Intracoronary drugs
After an appropriate spectral Doppler signal and a baseline left coronary angiogram were obtained, the following studies were performed, according to an established protocol. First, bradykinin (Clinalfa AG, Basel, Switzerland) was infused into the left coronary artery through the guide catheter by pump. After a 3-min infusion of warm 0.9% saline solution at a rate of 1 mL/min, incremental doses of bradykinin were infused, namely 50, 150 and 250 ng/min, at a rate of 1 mL/min, each for 3 min. A 3-min recovery period was observed between the successive bradykinin doses. Second, a bradykinin bolus (400 ng/3 mL) was injected through the guiding catheter into the left coronary artery, preceded by a 3-mL bolus of warm 0.9% saline solution, both for 10 s. Third, acetylcholine (Pharmacie Centrale des Hôpitaux, Assistance Publique, Paris, France) was administered into the left coronary artery through the guide catheter by pump. After a 3-min infusion of warm 0.9% saline solution at a rate of 1 mL/min, increasing doses of acetylcholine were infused, in order to achieve the estimated blood concentrations of 10-8, 10-7 and 10-6 M in the left coronary circulation assuming a blood flow of 120 mL/min for a dominating left coronary artery and of 100 mL/min for a dominating right coronary artery. Infusion rate was 1 mL/min for 3 min for each concentration. A 3-min recovery period was observed between the successive acetylcholine doses. Lastly, a linsidomine bolus (Sin-1) (1 mg/3 mL) was injected into the left coronary artery to assess the vasodilatory response of the coronary arteries to a nonendothelium-dependent vasodilator.
Serial manual injections of a nonionic contrast agent (Iopamidol, Schering, France) into the left main stem were performed at baseline, immediately after each drug dose (10 to 15 s after infusion termination), at the end of each postinfusion recovery period, 30 s after the warm saline and bradykinin boluses and 3 min after Sin-1 injection. Special care was taken to quickly withdraw the fluid contained into the catheter and coronary device before each contrast agent injection. Because velocity variations after contrast agent injection can be anticipated, the velocity reflecting the effects of the various tests was measured before each contrast agent injection. Systolic, diastolic and mean aortic pressure, heart rate and the electrocardiogram were monitored continuously throughout the investigation.
Doppler flow wire and calculation of coronary blood flow
The Doppler guide wire position in the proximal left anterior descending was the same throughout the study. Spectral Doppler frequency analysis was recorded continuously throughout the experiment. Time-average peak velocity was used as a measure of mean coronary blood flow velocity (17). Coronary blood flow was calculated by multiplying one-half this value by the calculated coronary artery area at the tip of the Doppler flow wire on the corresponding angiogram, and by using a 0.6 conversion factor for mm2/cm2 and min/s. Coronary blood flow variations during the different tests are reported as the percent change versus baseline.
Quantitative coronary angiography
A CGR (General Electric, Issy les Moulineaux, France) X-ray unit connected to a DPS PLUS system (ADAC Laboratories, Milpitas, CA) was used in all studies. The size of the image intensifier was 6 in. The digital system and software analysis program (ARTREK; ADAC Laboratories) used in this study, which allow a fully automatic edge-detection and quantitation of coronary segments, have been validated previously (18). For each patient, the angiographic system was set up in the right anterior oblique position, with adequate cranial or caudal angulation allowing analysis of the left arterial tree on end-diastole frames without overlap of the selected segments. The proximal and middle portion of the left anterior descending coronary artery and the proximal portion of the left circumflex artery were positioned near the isocenter. Using this view, pincushion distortion was found to be small because measurements made at the periphery of the zone of interest varied by only 5% from those made at the center (19). Because the position was kept the same throughout the experiment, and relations between focal spot, patient and image intensifier height remained unchanged, no correction for distortion was introduced. Digitally acquired images coupled to an electrocardiograph monitor were recorded at the rate of 25 frames/s. End-diastolic frames were analyzed using 4× magnification to help provide adequate pixel resolution for small vessels and catheters. The distal end of the injection catheter served for calibration with automatic tracking for edge determination. Fixed anatomic coordinates were used to reproduce the same regions of interest to assess serial changes. Three defined regions of the proximal and middle left anterior descending coronary artery and of the proximal left circumflex artery were selected in both control subjects and HTXs. In both groups, coronary segments analyzed were approximately 10 mm in length (mean 9.7 ± 2.7 mm). Automatic vessel segment contour detection was performed and the averaged diameter of each segment was obtained directly from the computer. Additionally, measurements were made by two operators blinded to the conditions under study. Interobserver (standard error of estimate for repeated measurements in percent of mean vessel diameter) and intraobserver variabilities using this system were found to be low (4.3 and 4.7%, respectively). Responses of coronary arteries to the various stimuli are reported as the percent change versus the control value.
Statistical analysis
All data are reported as mean ± SDs. When applicable, comparisons between groups were performed using unpaired t tests. Two-way analyses of variance (ANOVAs) with repeated measurements were performed. The effects of drugs on luminal diameter, coronary blood flow velocity and estimated coronary blood flow were compared in both groups, testing for group effect, dose effect and interaction. When applicable, the Fisher protected least significant difference test or the Dunnett's test for comparisons with control values were used. Statistical difference was assumed if the null hypothesis could be rejected at the 0.05 probability level.
Study population characteristics
The age of transplant donors was similar to the age of control subjects. The two groups were similar with respect to left ventricular dimensions, fractional shortening and left ventricular mass. Lipid profile was normal and similar in the two groups. Eight transplant patients had histological signs of rejection justifying augmented immunosuppressive therapy (two patients had rejection grade 2, and six rejection grade 3, according to the ISHLT classification); none of these eight patients had hemodynamic compromise (Table 1).
Systemic hemodynamic responses
The data are summarized in Table 2. All patients were normotensive at the time of investigation. At baseline, heart rate and the rate-pressure product were significantly higher in HTXs than in control subjects. Bradykinin in graded doses and as a bolus did not alter systemic hemodynamics, except for the 150-ng/min dose, which induced a slight but significant decrease in systolic aortic pressure (-5 ± 3%, p < 0.01) and rate-pressure product (-8 ± 9%, p < 0.05) in the control subjects but not the HTXs. Acetylcholine did not modify systemic hemodynamics in either group. Linsidomine induced a significant fall in systolic aortic pressure (-8 ± 9%, p < 0.01) and in the rate-pressure product (-7 ± 10%, p < 0.01) in the HTXs but not the controls.
Effects of bradykinin on coronary epicardial vasomotion and blood flow
The effects of drugs on coronary epicardial vasomotion and blood flow are summarized in Table 3. At baseline, the averaged mean coronary diameter of the three segments assessed in each patient was higher in HTXs than in control subjects: 2.7 ± 0.8 mm versus 2.3 ± 0.7 mm, p < 0.05. Bradykinin induced significant and similar vasodilation of all measured epicardial segments in both groups, in a dose-dependent manner: 11 ± 12% , 19 ± 14% and 22 ± 16% (all p < 0.0001) with bradykinin doses of 50, 150 and 250 ng/min, respectively (Figs. 1 and 2 ). ⇓⇓ Bradykinin-induced vasodilation was comparable across the three coronary artery segments assessed. Vasodilation in response to the bradykinin bolus was similar to that observed with the lowest-dose bradykinin infusion: 10 ± 16% (p < 0.0001).
The average peak velocity of coronary blood flow was slightly but nonsignificantly higher at baseline in the HTXs (23 ± 8 cm/s) than in the control subjects (17 ± 4 cm/s). It also increased in a dose-dependent manner during bradykinin infusion in both groups: 22 ± 24% (p < 0.001), 72 ± 40% and 111 ± 50% (both p < 0.0001) (see Figs. 1 and 2). In contrast, the bolus of bradykinin induced a small, nonsignificant, transient increase (less than 10 s) in average peak velocity, which was no longer present at the time angiography was done (10 ± 13% in control subjects, 5 ± 13% in HTXs).
At baseline, estimated coronary blood flow was higher in HTXs (68 ± 28 mL/min) than in control subjects (33 ± 13 mL/min), although the difference was not statistically significant. As a result of the effects of bradykinin, estimated coronary blood flow increased in a dose-dependent manner in both groups: 50 ± 40%, 130 ± 68% and 186 ± 77% (all p < 0.0001) (Fig. 1). The bradykinin bolus induced a small increase in coronary blood flow in both groups (49 ± 44%, p = NS in control subjects, 21 ± 21%, p < 0.01 in HTXs).
Effects of acetylcholine and Sin-1 on coronary epicardial vasomotion and blood flow
The effects of acetylcholine on the epicardial vasomotor response were strikingly different in both groups of patients (two-way ANOVA, p < 0.0001 for interaction). In control subjects, the increasing-dose acetylcholine infusions produced increasing degrees of epicardial vasodilation at estimated concentrations of 10-8 to 10-6 M: 1 ± 7% (p = NS), 7 ± 9% (p < 0.001) and 12 ± 13% (p < 0.0001) (see Fig. 1). Acetylcholine did not produce constriction on any of the 21 segments analyzed.
In HTXs, a progressive reduction in luminal diameter was observed. More specifically, mean epicardial segment diameter diminished by 2 ± 8% (p < 0.05), 7 ± 8% (p < 0.0001) and 11 ± 14% (p < 0.0001) at estimated acetylcholine concentrations of 10-8, 10-7 and 10-6 M. Of the 48 coronary segments assessed in HTXs, only five showed dilation at the estimated acetylcholine concentration of 10-7 M.
The effects of acetylcholine on average peak velocity and on estimated coronary blood flow were similar in both groups of patients (both two-way ANOVA, p for interaction NS).
A dose-dependent increase in average peak velocity was observed: 16 ± 13% (p < 0.001), 59 ± 47% (p < 0.0001) and 141 ± 57% (p < 0.0001), yielding a coronary blood flow increase of 14 ± 21% (p = 0.03), 54 ± 46% (p = 0.0001) and 138 ± 90% (p < 0.0001) (Fig. 1).
Linsidomine induced marked and similar epicardial vasodilation in both groups (Figs. 1 and 2): 25 ± 16% (p < 0.0001), with a concomitant decrease in average peak blood flow velocity: -32 ± 15 (p < 0.001). As a result, estimated coronary blood flow did not change significantly in either group.
Influence of acute allograft rejection on vasomotor responses to bradykinin and acetylcholine
Because 8 of our 16 HTXs had evidence of transplant rejection on the study day, we were able to compare responses to bradykinin and acetylcholine in the presence versus the absence of rejection. Hemodynamic and left ventricular echocardiographic parameters were not significantly different in these two HTX subgroups.
Epicardial and microvascular responses to the stepwise bradykinin infusions were similar in HTXs with and without rejection, resulting in similar coronary blood flow increases (Fig. 3 ) (two-way ANOVA, p for interaction = NS). Conversely, the acetylcholine-induced coronary blood flow increase was smaller in HTXs with rejection (two-way ANOVA, p < 0.05). This significant difference in the response to acetylcholine found at estimated concentrations of 10-7 and 10-6 M was due to the combination of a smaller increase in average peak velocity (p < 0.05 at the estimated concentration of 10-6 M) with a nonsignificant trend toward more epicardial vasoconstriction in HTXs with rejection.
The main finding of this study is that epicardial and microcirculatory vasodilator responses to intracoronary bradykinin infusion are preserved in recently transplanted donor hearts. In addition, this normal coronary vasomotor response is not impaired in the presence of acute allograft rejection. These results contrast with the abnormal vasoconstricting responses to acetylcholine in the same patients and imply that some endothelium-mediated vasodilator mechanisms are intact in recently transplanted hearts.
Bradykinin-induced coronary vasodilation
Bradykinin is a potent vasodilator whose effects on the systemic and coronary circulations were described in animal models many years ago (20). However, the effects of exogenous bradykinin on the human coronary circulation were documented only recently by Kuga et al. (16). These authors reported that intracoronary administration of bradykinin dilated normal human epicardial coronary arteries in vivo. Our results confirm and extend this finding, because in our control subjects bradykinin elicited not only epicardial but also significant coronary microcirculatory dilation, in a dose-dependent manner. The coronary blood flow increase was independent of hemodynamic conditions, as demonstrated by the absence of heart rate or aortic pressure variations during bradykinin infusion. Because of the marked effect of bradykinin on coronary resistance vessels, it could be argued that epicardial vasodilation was due to a flow-dependent, endothelium-mediated mechanism. Nevertheless, when bradykinin was infused as a bolus, the coronary blood flow velocity increase was extremely short-lived, having disappeared at the time angiography was performed. These data indicate that epicardial vasodilation was due to a direct effect of bradykinin.
Mechanisms of bradykinin-mediated vasodilation
Bradykinin is an endothelium-dependent vasodilator. In vitro and in vivo studies have shown that the effects of bradykinin are mediated through nitric oxide and prostacyclin pathways (11–13), as well as through the release of an endothelium hyperpolarizing factor (13–15). The relative contribution of these three factors in mediating epicardial and microcirculatory dilation in vivo are not yet well defined (21,22). Nevertheless, blockade of bradykinin B2 receptors with the selective antagonist HOE 140 has been shown to decrease basal epicardial luminal area and to increase coronary vascular resistance, producing a fall in coronary blood flow. Moreover, flow-dependent vasodilation is blunted after blockade of bradykinin B2 receptors (23). These findings underline the important role of endogenous bradykinin in the control of epicardial and microcirculatory vasomotor tone in humans.
Bradykinin-, acetylcholine- and Sin-1-mediated effects in transplant patients
The vasodilator response to exogenous bradykinin is blunted in epicardial atherosclerotic segments in humans (16). Also, pharmacological or mechanical removal of endothelial cells in coronary microvessels blunts vascular relaxation to bradykinin (24,25). Thus, the vasomotor response to exogenous bradykinin may be considered a marker of a functionally active endothelium, both in conduit and in resistance coronary vessels.
The results of our study show that endothelium-mediated responses to intracoronary bradykinin are preserved early after heart transplantation. Heart transplantation is associated with many factors potentially responsible for endothelial dysfunction, including cardiac denervation (26), ischemia during transplant harvesting (27), use of cardioplegic solutions (28), immunologically mediated injury to the endothelium (29) and effects of cyclosporine (30). Moreover, although the pathogenesis of transplant atherosclerosis is not yet well understood, any injury to the endothelium and subsequent impairment in vascular response may be capable of initiating this form of accelerated atherosclerosis (31).
Paradoxical epicardial vasoconstriction in response to acetylcholine is thought to be a hallmark of endothelium dysfunction and has been demonstrated even before the development of angiographically visible atherosclerosis in nontransplant patients (5,32). Several studies (1–3) have shown that the response of transplant epicardial coronary arteries to intracoronary acetylcholine is abnormal in most transplant recipients, even early after transplantation. Although this abnormality is generally ascribed to decreased activity of endothelium-derived relaxing factors, other mechanisms deserve to be considered, such as acetylcholine-mediated release of cyclooxygenase-dependent vasoconstricting factor, and alterations in endothelial receptor responses to acetylcholine or disequilibrium between endothelial and vascular myocyte receptors due to denervation.
In our study, the same epicardial coronary segments that dilated in response to bradykinin in HTXs exhibited paradoxal vasoconstriction to stepwise acetylcholine infusions. In contrast, the microcirculatory vasodilator response was similar with the two drugs, as shown by the comparable increase in the average peak velocity of coronary blood flow after bradykinin and acetylcholine. These differential effects of acetylcholine on large epicardial compared with smaller resistance coronary vessels have been described previously, but remain incompletely explained (6). In HTXs, the coronary blood flow increase associated with the effects of acetylcholine on coronary resistance vessels has been reported to decrease over time after transplantation (33). Because transplant atherosclerosis is a progressive, diffuse, concentric process that is marked in the distal coronary tree (34), endothelial dysfunction should be present simultaneously at the epicardial and at the microcirculatory levels, even before the development of angiographically visible lesions.
Bradykinin shares with acetylcholine one of the main endothelium-dependent vasodilator pathways: both compounds elicit nitric oxide release by the endothelial cell (11,12,35). Thus, although the vasoconstriction observed with acetylcholine at the epicardial level reflects endothelial impairment, our findings, in agreement with previous studies, imply that some endothelium-dependent vasodilator pathways are preserved early after transplantation, the nitric oxide pathway probably being among them.
Linsidomine, the active metabolite of molsidomine, is a direct nitric oxide donor responsible for selective vasodilation of epicardial conductance vessels via mechanisms independent from the endothelium and from cysteine (36). Coronary blood does not change or diminish after intracoronary Sin-1 infusion (9), because of epicardial vasodilation without concomitant microcirculatory effects. Moreover, in our HTXs but not our control subjects, 1 mg of Sin-1 induced systemic hemodynamic changes with significant decrease in the rate-pressure product.
Vasomotor responses in the presence of acute graft rejection
An additional finding from our study is that the coronary vasomotor responses to bradykinin are similar in the presence and absence of acute allograft rejection. Acute rejection is an inflammatory process, which involves the coronary bed of the graft. Vasoactive substances are released during rejection, most notably cytokines (37), which can cause endothelial injury and dysfunction but also act directly on vascular smooth muscle cells. In a recent study of a swine model of retroperitoneal heterotopic heart transplantation, Perrault et al. (38) found that endothelial dysfunction in untreated acute rejection developed after five days, initially involved G-proteins, and worsened over time, ultimately affecting all endothelial mechanisms and vascular smooth muscle. Thus, multiple abnormalities may explain the impairment in myocardial perfusion observed during severe rejection in animal models (39). In our study, the estimated coronary blood flow at rest and the rate-pressure product were similar in patients with and without rejection. Endothelial dysfunction, as evidenced by the abnormal vasomotor responses to acetylcholine, was significantly more marked in patients with rejection, because acetylcholine at estimated concentrations of 10-7 and 10-6 M induced more epicardial vasoconstriction and a smaller increase in the coronary blood flow velocity in HTXs with rejection. Conversely, exogenous bradykinin induced a potent vasodilator response at the epicardial and microvascular levels even in patients with rejection, suggesting that endothelium-dependent vasodilator mechanisms may compensate for endothelium impairment during rejection. Our findings suggest a protective role of endogenous bradykinin in rejection, consisting in preservation or even augmentation of coronary perfusion via upregulation of B2 and/or B1 receptor subtypes. Confirmation of this mechanism would support use of angiotensin-converting enzyme (ACE) inhibitors after cardiac transplantation, because ACE inhibition potentiates local effects of bradykinin through the nitric oxide and/or prostaglandins pathways (40,41). In addition, chronic ACE inhibition has been shown to reduce significantly myointimal proliferation in a rat heterotopic transplant model, suggesting that angiotensin II may mediate the myointimal proliferative response in transplant coronary artery disease (42). Interestingly, in the same model, chronic ACE inhibition reduced cellular rejection and perivascular edema, indicating that angiotensin II modulates the cellular population during the rejection process.
Study limitations
First, neither the relative contribution of the various endothelium-mediated effects of bradykinin nor the effects of selective stimulation of B1 and B2 bradykinin receptors were addressed in our study. Second, it is possible that some of our HTXs had already developed some degree of angiographically silent intimal thickening that could have been detected using intravascular ultrasound. However, endothelial dysfunction, as evidenced by a paradoxical response to acetylcholine, has been shown to occur in HTXs even in the absence of intimal thickening (43). It is not known whether the vasodilator response to bradykinin is blunted in the presence of transplant atherosclerosis.
We found evidence that the endothelium-mediated vasodilating effects of bradykinin are preserved early after heart transplantation. Although there was an abnormal vasoconstricting response to acetylcholine reflecting endothelium impairment, our data indicate that the endothelium remains a functionally active organ in heart transplant recipients. Moreover, bradykinin may play a protective role in acute rejection, preserving or even increasing myocardial blood flow. Further investigations are necessary to determine whether ACE inhibitor therapy after heart transplantation is a useful therapeutic approach.
- Abbreviations
- angiotensin-converting enzyme
- endothelium-derived hyperpolarizing factor
- transplant patients
- Sin-1
- linsidomine
- Received December 31, 1998.
- Revision received November 24, 1999.
- Accepted January 13, 2000.
- American College of Cardiology
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text:
The first time I had heard of this when Lil Muallim 1 got it as an assignment for his online grdae 9 English course. To be honest we all enjoyed the process. I am pretty sure I have images of the very first Found Poetry project in our house somewhere.......but for now I can share Lil Muallim 2's take on it.
Inacse you are still wondering what found poetry is..... In simple words its taking chunks of existing text and putting them together as desired to create new meanings. Truly a very creative form of poetry.
Presenting Lil Muallim 2's 1st Found Poetry:
(he got his text snippets from Pottery Barn catalogues that he found)
I just LOVE the way the rearrangement can change the phrase conotations. This is one way of doing found poetry, would really like to explore more. You can learn more about it and ideas from homeschooling-ideas and poetry4kids.


text:
The Zappa battles are long, strange and going on for decades.
Frank Zappa died in 1993. A long and curious estate fight has gone on ever since, according to TMZ in "Frank Zappa Family War Dweezil vs. Ahmet and Diva."
The estate battle between Zappa's children is over the use of his name and his music. Many legal motions have been filed.
Dweezil Zappa, who had desired to go on tour and play his father's music in concerts, has toured under the title "Zappa Plays Zappa."
Dweezil, however, does not have control over the estate. That is in the hands of his younger siblings Ahmet and Diva Zappa.
Dweezil has previously contended that Ahmet and Diva refuse to let him use the family name and their father's music while on tour, without paying them royalties.
Ahmet and Diva Zappa have now filed a motion with the court for what appears to be a strange purpose. They seek permission from the court to create a website, specifically to refute their brother's claims.
For their part, these siblings contend that they have always been willing to let Dweezil do what he wants for a small fee of one dollar. They also state that Dweezil is tarnishing the family name by spreading what they call lies. Therefore, they need to counter the lies.
It is not clear why they would need the court's permission to do this.
This feud over their father's estate has gone on for so long and is so strange, that it is unlikely about the music.
Reference: TMZ (March 13, 2017) "Frank Zappa Family War Dweezil vs. Ahmet and Diva."


text:
1849 S Treadaway Blvd
Abilene, TX 79602
Green Ford-Chrysler-Dodge-Jeep
2104 N Buckeye Ave Abilene, KS
2005 N Buckeye Ave Abilene, KS
This company painted my SIL's car and did a great job. She had it red and wanted it black and they did a fantastic job. I would definitely recommend using them.5


text: So weekly Treasuries have kind of gone out the window but, I'll still be showing some from time to time. here is another one for those who dream to live and live to dream. This one is called Once Upon a Time… and features some lovely and dreamy items. Here's a quick look:


text:
Save and Track Your Favourite Properties
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Residential property sales recorded through the MLS® System of the Barrie & District Association of REALTORS® Inc. numbered 394 units in October 2013. This was up two per cent from last October.Within the City of Barrie sales activity was up seven per cent from a year earlier. The City of Barrie saw 244 residential sales in October. Resale housing demand in the region has been very strong ...


text:
Welcome to The Antagonists guide at TV Tome. Jack Scarlett and Kate Ward are a pair of Los Angeles lawyers who regularly face each other in the courtroom: he as a defense attourney with a reputation for unconventional and even outrageous behaviour, she as a prosecutor who does everything strictly by the book. Outside the courts, they have a close relationship with each other, but it becomes increasingly strained with each legal battle they fight.
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text:
Missy Bon Bon
Mactan International Airport, Lapu-Lapu Airport Rd., Lapu-Lapu, Cebu
- 1 Reviews
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- Category:
- Bakery
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Really cheap rice toppings with generous ulam. Got the shrimp balls which was a combination of mushrooms and shrimp balls... Warmed my belly with hot hot rice! Only for something like Php120 (if I remember it correctly!)z cheapest rice topping I could find at the airport... Rice toppings are Php160 at most, if memory serves me right.
Forgive me... At naia3 airport at 3 a.m. and flew out of Mactan at 7 p.m. Wasaaaak!
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text:
Volya strikes back with another unconventional speaker design…
The loudspeaker enclosure is made of metal with vibration-absorbing filled steel elements and fiberglass armored composite with inner stiffeners. Inside the enclosure there is a layer of sound standing waves damping material. Ultra-pure copper cable applied for inner connections as well as crossover components are produced by company Mundorf®, Germany. The connection terminals are produced by German manufacturer WBT®. German drivers Accuton® are used in in the loudspeaker systems. Woofers are 280 mm sized with membranes of Kevlar and ceramic sandwich, mid-range drivers are 90 mm sized and tweeters are 25 mm sized with ceramic membrane.
Maximum power 150 W
Impedance 4 Ohm
Frequency range 25 Hz-27000 Hz
Type of low frequency design bass reflex with back port
Crossover type 3 ways
Crossover frequencies 300 Hz, 3000 Hz
Woofer 11"' ceramic-kevlar sandwich
Mid-range driver 5", ceramic
Tweeter 1" ceramic
Weight 380kg/pair
Dimensions (WxHxD) 1200x1200x700 mm


text:
Evasive Maneuvers
Euphemisms old and new
Customers of Size? More Like Terms of Twaddle
July 8, 2015By Mark Peters
White House security has been one of the most reliable sources of comedy for the past several years, with scandal and buffoonery becoming the norm. Finally, the buffoonery has produced something I can use in endless search for tasty euphemisms. Continue reading...


text:
HeraldMail Home
Town Hall
Attorney for town of Smithsburg resigns
May 6, 2011
Charles F. Wagaman Jr., who has served as attorney for the town of Smithsburg for the past 13 years, has tendered his resignation. The resignation was announced by Smithsburg Mayor Mildred "Mickey" Myers during a town council meeting Tuesday night. Myers read a letter of resignation from Wagaman in which he said he had enjoyed working with the town's elected officials. Wagaman's resignation is effective June 30, or earlier if the town finds another attorney, Myers said.
Hancock officer resigns
By SCOTT BUTKI
December 8, 1999
HANCOCK - Hancock's newest police officer has quit to take a job as a Frederick County (Md.) Sheriff's Department deputy. Police Chief Donald Gossage announced during Wednesday's Hancock Town Council meeting that Officer Bart Ruppenthal, 26, has resigned less than one year after he was hired. Gossage and Mayor Daniel Murphy said they wouldn't comment on Ruppenthal's resignation or the reasons for it. Reached after the meeting, Ruppenthal said he quit so he could go to work for the Sheriff's Department.
Mayor explains resignation
September 13, 2000
Mayor explains resignation SHARPSBURG - Sharpsburg Mayor George Kesler said Tuesday morning he had been trying to hold off on retiring as mayor, but could no longer do so. Kesler said he resigned, effective at noon Monday, for personal reasons. He would not elaborate. Vice Mayor Sidney Gale, who is now mayor, found Kesler's letter of resignation at Town Hall before Monday night's Mayor and Town Council meeting. "I've been trying to avoid this for the past six months.
Smithsburg council member resigns
By DAVE McMILLION
January 6, 2009
SMITHSBURG -- Smithsburg Town Council member Tom Chiarizia has resigned because of new job demands that make it impossible for him to serve on the council, Mayor Mildred "Mickey" Myers said Monday night. Town council members will select a replacement for Chiarizia, although it is not known when that will happen, Myers said. Myers said Chiarizia's new job involves working evenings, which conflicts with town council meetings. Myers said she received a letter of resignation from Chiarizia before the holidays and his resignation became effective around Dec. 31. Chiarizia was elected in 2006 and was serving a four-year term, Myers said.
Councilwoman's resignation not accepted
By CLYDE FORD
July 21, 1998
HARPERS FERRY, W.Va. - Harpers Ferry Mayor Walton "Kip" Stowell would like Annette Hale to return to the council seat she resigned from earlier this month. "We've not accepted her resignation as such. We hope she would come back," Stowell said. The Harpers Ferry Town Council met Monday night with Hale, who resigned July 8, saying she did not believe the town properly handled the dismissal of a Harpers Ferry police officer. "She's been a good council member. We're holding it open.
Greencastle councilman resigns
By KATE S. ALEXANDER
March 2, 2009
GREENCASTLE, Pa. --Â Greencastle Borough Councilman Christopher Grimm resigned his council seat Monday after just two years in the position. In a letter dated Feb. 2, Grimm tendered his resignation from council effective March 31. He cited increased responsibility at work as his reason for leaving the council. "I will resign my Borough Council seat in order to take on more responsibility at my employer," he wrote. "It has been my pleasure working with each of you and serving the borough, however, my priorities must shift in order to provide more time for my new role.
Accused county worker resigns
By SCOTT BUTKI
January 5, 2000
Steven Kenneth Spalding, 45, who was arrested last week on sex charges, resigned his county government job Wednesday, Washington County Attorney Richard Douglas said. cont. from front page The resignation was the result of negotiations between Douglas and D. Bruce Poole, Spalding's attorney, following Tuesday's closed session of the Washington County Commissioners, Douglas said. Spalding will receive no compensation from the county for his resignation beyond post-termination benefits given to all employees under county personnel policies and state and federal law, Douglas said.
Musselman High principal resigns
By DAVE McMILLION, Charles Town
September 15, 1998
MARTINSBURG, W.Va. - Musselman High School Principal John J. Cole, who was placed on administrative leave while state police investigate possible misuse of school funds, has resigned, a school official said Tuesday. Berkeley County Schools spokeswoman Mary Jo Brown said Cole's resignation has nothing to do with the investigation. The Berkeley County Board of Education voted unanimously Monday night to accept the resignation of Cole, who has been with the school system for 35 years and led Musselman High for more than 20 years.
Williamsport's clerk/treasurer resigns
By ANDREW SHOTZ
November 30, 1999
WILLIAMSPORT James R. Castle has resigned after 20 months as Williamsport's clerk/treasurer. Castle's last day was Friday. He said he started a new job Monday as public works administrative coordinator for the town of Brunswick, Md. Castle, 30, said he was eager to return to Brunswick, his hometown. "It was a good time to make that move," he said. Williamsport has begun advertising for a replacement. An ad ran over the weekend in The Herald-Mail. Councilman Jeff Cline, a Realtor, said he's interested in the job, but he'd like to see a written description of the duties before deciding whether to pursue it further.
CVOI manager resigns
October 15, 1997
By RICHARD F. BELISLE Staff Writer, Waynesboro WAYNESBORO, Pa. - Illness has forced Peter Downey, the first general manager of the new ice skating rink being built west of Waynesboro, to resign his post, said Carol Henicle, chairman of the board building the rink. Henicle, who is also executive director of the Greater Waynesboro Chamber of Commerce, said Wednesday that Downey's resignation is effective Oct. 31. He left Waynesboro this week to return to his native Connecticut to attend his daughter's wedding Saturday, Henicle said.
Mercersburg Elementary School principal resigns
By ROXANN MILLER | email@example.com
June 27, 2013
Lura Hanks has resigned as principal of Mercersburg Elementary School, citing "professional incompatibility" as the reason for leaving the job she held since 2010. A week ago, the Tuscarora School Board decided to split Hanks' time between two elementary schools. "Due to recent executive decisions and situations, it was time for me to make a change," Hanks said in a telephone interview Thursday. On June 18, the board unanimously decided to approve an administrative change that would divide Hanks' time between Mercersburg and Montgomery elementary schools.
Boys Basketball: Easton resigns as Saint James coach
By TIM KOELBLE | email@example.com
March 11, 2013
Distance became a problem for Paul Easton. He hasn't lost the drive to coach basketball, but his drive to get to where he coached basketball was a little much. Easton resigned as boys basketball coach at Saint James last week following two years of commuting from his home in Herndon, Va. "Making a commute like this takes a toll on you and your family after two years," Easton said. "It was a tough decision, with the passion for basketball I have, to make. It was more than just about basketball." The Saints finished 13-14 with a toughened schedule this season following a 17-10 record in Easton's first year after succeeding Mike Brooks.
Head of Berkeley Co. alternative sentencing program resigns
March 7, 2013
The executive director of the Berkeley/Jefferson Day Report Center said Wednesday that he is resigning from the position to take a job that is much closer to his Harrisburg, Pa., area home. Jason Castillo, who replaced Joe Sacchet in May 2012, is resigning from heading up the grant-funded alternative sentencing program to work for Avertest as a regional manager at a forensic drug testing facility in York, Pa. Castillo said the hour and one-half commute to Martinsburg and gas prices factored into his decision to resign from what he said has been the greatest job he has ever had. "I'm very sad to go," Castillo said.
Berkeley County Roundhouse Authority chairman, wife, resign
By MATTHEW UMSTEAD | m
March 6, 2013
A Martinsburg attorney who has led efforts to preserve and redevelop the 19th century Baltimore & Ohio Railroad shops in Martinsburg for more than 15 years said it's time for the next generation to take over the project. Clarence E. "CEM" Martin III, who has chaired the Berkeley County Roundhouse Authority board since it was created in 1999, said Wednesday his resignation letter to Berkeley County Council President Tony Petrucci was delivered Monday. Martin's wife, Judy, who has served with her husband on the Roundhouse Authority for as many years, said separately Wednesday that she, too, had sent a letter of resignation to the county this week.
South High principal resigns for personal reasons
By JULIE E. GREENE | email@example.com
February 25, 2013
South Hagerstown High School Principal Timothy Dawson, who had been placed on paid administrative leave Feb. 6, resigned his post last Friday for personal reasons, Washington County Public Schools spokesman Richard Wright said Monday. Jeremy Jakoby, whose most recent position was supervisor of testing and accountability in the school system's Central Office, officially reported to South High on Monday as acting principal, Wright said. At the time Dawson was put on leave, Superintendent Clayton Wilcox wrote in an e-mail response to an inquiry from The Herald-Mail that, "Beyond confirming that he is on leave, I am not at liberty to discuss the matter further." "We don't comment about personnel matters," Wright said Monday.
Greater Waynesboro Chamber of Commerce Executive Director resigns
By ROXANN MILLER | email@example.com
February 22, 2013
After nearly six years as executive director of the Greater Waynesboro Chamber of Commerce, Carlene Willhide is leaving. Her last day will be March 22. She submitted her resignation to the chamber board Wednesday. Willhide said she is leaving her post to spend more time with her family. "I'm just going to be taking a little bit of a break. I worked the last 30 years full time in very demanding jobs," Willhide said. "I'm going to take a little bit of time to just regroup and spend some time with my family." Those family members include her husband Michael, her recently married daughter Meagan, son-in-law Chris and her great niece and nephew.
Many local Roman Catholic Church leaders surprised by pope's decision to resign
By DON AINES | email@example.com
February 11, 2013
For the first time since Gregory XII stepped down from the Throne of St. Peter in 1415, the leader of the Catholic Church is resigning. Pope Benedict XVI's decision to step down took by surprise many local members of the Roman Catholic Church on Monday. He said that at age 85, he no longer has the necessary physical strength to lead the world's more than 1 billion Roman Catholics. "I'm very surprised. Yet, when I think about his age and frailty, he's one of the smartest men, so he knows what's best for the Church," said Father John Lombardi of St. Peter's Catholic Church in Hancock, Md. "I am sad because I and many of the faith have a very high regard for Pope Benedict XVI," the Rev. J. Collin Poston, pastor of St. Mary Catholic Church in Hagerstown said Monday.
Jefferson County looking to avoid special election to fill sheriff's post
By RICHARD F. BELISLE | email@example.com
January 31, 2013
While no formal vote was taken Thursday, the Jefferson County Commission dropped plans for a special election this year to replace former Sheriff Bobby Shirley, who was forced out of office after pleading guilty in a federal civil rights violation case. Commission President Dale Manuel estimated that it would cost about $200,000 to hold a primary in May followed by a general election in November. The commissioners appointed Jesse W. Jones, Shirley's chief deputy, to serve as interim manager following Shirley's resignation.
Jefferson County sheriff tenders resignation, county commissioner says
By MATTHEW UMSTEAD | email@example.com
January 11, 2013
Jefferson County Sheriff Robert E. "Bobby" Shirley has tendered his resignation, Jefferson County Commissioner Patsy Noland said Friday. Noland said Shirley dropped off a one-sentence letter of resignation at her home between 5:30 and 6 p.m. "It says that he resigned as sheriff, effective immediately," Noland said. Commissioners have yet to formally discuss Shirley's resignation letter, Noland said. Noland and newly elected Commission President Dale Manuel said they were unaware that Shirley consented Friday to modified terms of release while federal civil rights allegations are pending against him. Shirley was placed on 24-hour home detention Friday and agreed to take leave of absence from his job, according to his attorney Kevin D. Mills and court orders.
Martinsburg-Berkeley County Visitors Bureau director submitted resignation months ago
By MATTHEW UMSTEAD | email@example.com
December 11, 2012
The resignation of the Martinsburg-Berkeley County Convention & Visitors Bureau's executive director apparently was in the works for several months. After more than six years on the job, Andrea Ball announced Thursday that she had resigned effective that day. When contacted about her resignation, Ball said Thursday that she submitted a letter of resignation to the bureau's board president April 25 that made her departure effective Sept. 21. "I am offering five months notice to give you an opportunity to find a replacement and to complete what I hope is a very successful Pickin' In the Panhandle 2012," Ball wrote in a letter to Kim Reid that she released Thursday to The Herald-Mail.
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Jessica Collings
I studied English Literature at Cardiff University. I had wanted to be a lawyer since I was at school, though admittedly the early 'being a lawyer' image in my head was some kind of saving the world with a gavel comic book character.
I began to get a more realistic view of the options for a legal career from various high street work experience stints and then secured a job as a legal secretary at a commercial firm in Cardiff whilst at University. I was lucky enough to progress to a paralegal position after three months at the firm as the partner I worked for left (or the firm decided my dictation understanding ability was terrible and wanted to politely reposition me) and I became the general paralegal support for the commercial property team. Whilst I enjoyed the technical aspects of the work and being able to solve a client's problems, I found that I was having something of a quarter life crisis (if I'm being optimistic about my longevity and we ignore the toll that four years of through the night essay writing has done to my health) between my more altruistic goals and my enjoyment of working in a commercial legal environment. I had been volunteering for Marie Curie Cancer Care throughout my undergraduate degree and also teaching to refugees through a student society. I really enjoyed helping enterprises that inspired me and reached out to the fringes of society and this was something that I was reticent to forgo by jumping straight into the corporate world of London city law firms.
I spoke to my colleagues in the voluntary sector and found that when they did outsource their legal work it was often to a firm called, and this will be an unexpected narrative turn I'm sure, Bates Wells Braithwaite. I researched the firm further and found that their work and in particular their client base really interested me and felt like a natural merger of my passion for the third sector and my enjoyment of the skills required for a commercial legal career.
I was lucky enough to get a training contract but as firms recruit two years in advance, I had a two year gap before starting, so I completed the LPC part time whilst working at other commercial law firms as a paralegal and working pro-bono for an East London legal clinic. I think that the paralegal experience has helped me to feel more confident starting my training contract at BWB, but the variety of experience and background at all levels of the firm means that there is no typical 'BWB trainee' – even without a paralegal background, you will find everyone very willing to explain concepts to you and nobody takes your level of knowledge for granted.
Currently in the Charity and Social Enterprise department, what I have enjoyed so far is how inspiring much of the client base can be and how much that affects your motivation to perform at your best. I also have had access to a huge variety of tasks, very few of which have been administrative, from the more corporate side such as drafting governing documents for charitable companies to more nuanced work such as researching and rebutting serious allegations in the media.
Another real selling point of the firm is the fact that I have so far managed to maintain my interests outside of work easily, which include a volunteer role, being in a choir and working on a project for a large Charity outside of my capacity as a BWB Trainee. You are actively encouraged to pursue your outside interests and the work life balance here reflects that


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Home loan servicer Vericrest Financial Inc. appointed Ben Purser its chief risk officer this week.
Purser assumed his new duties on Monday, Jan. 7. He brings more than two decades of experience in the mortgage lending industry to Vericrest and most recently served the Office of Financial Stability at the United States Department of the Treasury as chief compliance officer.
Sponsor Content
In that role, Purser oversaw compliance issues related to the Troubled Asset Relief Program.
Purser previously held senior leadership positions at FBR Capital Markets Corp., Riggs Bank and served the Federal Deposit Insurance Corp. in the securities, capital markets and trust branch.


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New Play Development
New Plays. New Orleans
Southern Rep Theatre is committed to the development and production of new plays and playwrights. Our program 4D creates teams of dramatists, directors, and dramaturgs in New Orleans to create three new full-length plays every season. The Ruby Prize is our $10,000 bi-annual award to a woman playwright of color named in honor of Ruby Bridges, who showed incredible perseverance in the face of formidable obstacles. Finalists for the Ruby Prize present their work in the New Play Bacchanal, a multi-day series of several staged readings open to the public for low or no cost.


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The theme for August 2013 is The Star. We can't wait to see your entries! Normal guidelines apply as stated here.
Here's a brilliant author story for inspiration:
The Star by Helen Douglas by Helen Douglas (August 2013)
Everyone else is looking at the sky. I'm looking at the corner of Pond Street, waiting for Ben. He always comes at seven, his skateboard tucked under one arm.
He doesn't know I exist.
It's been eight weeks since the last ship left for the new world. Ben's girlfriend is on one of them.
There aren't many of us left. We have new rituals, new superstitions. We wake early, opening our curtains to check the sunrise. At sundown we gather in parks to watch the red rays of sunset scorch the sky.
The children come out first. They spin on the roundabout, kick back on the swings, their eyes fixed on the sky. The last to come are the old folks. They bring buckets of popcorn and sit on park benches as though they're at the movies, watching some blockbuster rather than the dying days of our sun.
Ben appears then. He pauses, not heading to the half-pipe as usual. Instead he flops into the swing next to mine.
"Hey," he says.
I try to keep my voice steady. "Hey."
We swing in silence.
"Do you know which star they're heading towards?" I ask, eventually.
He points. "That one."
"I wonder how they are."
His hand brushes against mine. "I don't see the point of thinking about the people that left us behind. Do you?' He smiles.
Nobody knows how long we have left. Months? Days maybe.
But right now, I have everything I could ever want.


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Customize A Shopify Site (coding required)
Budget $250-750 USD
We have a ecommerce site we are going to open with shopify. We have purchased the "Atlantic" template. We need someone to complete the template to our specifications (which is easy) but we need customization of the product templates to include:
1. Creating images as thumbnails for variants (color variant: image of color) -- there will be multiples of these
2. Change the primary product image on selection of variant (would prefer a javascript image change - no refreshing)
3. Ability to add more than 3 variants
4. Ability to add text fields to product page where customer can type in text form responses (not multiselect which is the only thing shopify supports natively)
IMPORTANT -- If you are to be considered for this job, you must be a shopify expert, and you MUST specify in your email that you can do all of the 4 major requirements above.
34 freelancers are bidding on average $586 for this job
Hello there, Greetings! We have gone through your job description and would like to convey you that we are the best match for this task as we are a team of prolific Shopify Ninja working on e-Commerce developmen More
Hi There, Thanks for posting this job. **Few questions : 1) Do you want add any functionality ? 2) Do you require any design for the website ? 3) Please share the details of your website. I am expert in Shopif More
Hi I am available to work on your project and I can do all tasks mentioned by you. Shopify Ecommerce Projects:- [login to view URL] [login to view URL] [login to view URL] [login to view URL] More
Hello, I saw you want to customize your shopify site, and I would like to express my interest in your project. I confirm I can do all of your 4 major requirements.I'm looking for discuss with you via private message More
No one can do the point 3 "3. Ability to add more than 3 variants", it is limited by Shopify. Hi, I'm senior web developer and I'm very interested in your project. I've done many Shopify projects. These are my re More
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Hi there, I'm Shopify developer and designer with 6+ years of experience in Providing basic Setup and full Design&Development website form scratch, as well as customization existing theme and functionality upg More
Dear Client, Thank you for reviewing my proposal. We have expertise level on Shopify platform and have developed lots of websites for different industry verticals. We have developed several customized shopify sto More
Hello I am a Shopify expert with 4 years of rich experience. Stores optimized / built by me. Some of my work in Shopify Industry:- [login to view URL] [login to view URL] [login to view URL] htt More
We're Shopify design & development experts ([login to view URL]) and would like to assist you on customizing the store. Please check given below referral links to get assured about our skills: http More
Hi,I have gone through your project description. I could be confident if we can proceed towards more discussion. I am an individual developer and you will be working directly with me if we proceed work on this project More
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Hi, My bid is high but I can do all the 4 task you mentioned. Select me as your developer. My work is guaranteed. Regards


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Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4
Shot to Death
31 Stories of Nefarious New England
By Stephen D. Rogers
Mainly Murder Press, Wethersfield, CT
Soft cover, 257 pgs., $14.95
Short stories can be difficult to craft. With a longer novel, a writer can occasionally relax and let the characters enjoy a glass of wine or stop for a quick swim. Not so with short fiction, and least of all with the genre best known as "hardboiled" crime. Given the necessity of knocking you over the head with a feel for characters and setting, and what with the strictures of space, the writer is somewhat pressed to set the scene, and get you there fast. Every sentence should add to the quality of tension, and, mind you, make it hard for a reader to put the book down – good hard-boiled writers can do "dark" so well you may not want to go where they are taking you, but on the other hand, you have to finish the story.
Stephen D. Rogers, who lives in Wareham, has proffered a collection of short takes in Shot to Death: 31 Stories of Nefarious New England, and on some fronts he gets it right in the telling. A host of characters inhabits these shorties, and the loners, ex-cons and losers are definitely – and appropriately – on the down side of life. Private investigators pick the wrong clients; ill-lit fast food joints serve up saturated fats and heartburn; petty thieves dream of big jobs, and drink whiskey from food jars. The author's best first lines serve up a quintessence of noir: "She was waiting for him in canned goods, walking up and down the aisles…" while some titles give that satisfying hint of solid pulp: "Fill It With the Cheapest," "Itching for Scratch," or "A Dog Named Mule" come immediately to mind.
In Rogers' best stories, character development is front and center, and it's achieved with simple brushstrokes. "Inn" conveys a lifetime of "can't ever seem to get it right" in a few short pages. "A Friendly Game" turns the tables cleverly in an understated way, as does "Custody Battle at Red Creek," where a small-time PI gets his own back – literally. "Whacking for Gomez" humorously illustrates how a couple of hitmen just can't win for losin'.
What sets those particular stories apart is their ability to catch the browns and grays of the characters quickly, subtly and persuasively. We don't have to be told that good doesn't always (or even hardly ever) triumph, we believe it when we can picture the droop of a jawline or the tilt of a faded lampshade, when we can taste a character's sense of let-down.
In several other stories, though, we get the trappings but not the substance of good hard-boiled fare. The dialog overwhelms, dissipating the tension. In eight-plus pages of "The Big Stor,e" we get lost in mismatched verbal sorties that blur the story's edges. Similarly, "Jumping the Fence" is meant to be lightened with wisecracky humor, but all that talk never gets us below the surface. At its end, we don't know the characters much better – if we've gotten that far without dozing. Rogers is most successful when he lets the camera roll on the actions of his characters rather than on talky passages that obscure the story's rhythm.
In an article on detective fiction, mystery author P.D. James wrote: "If it is true, as the evidence suggests, that the detective story flourishes best in the most difficult of times, we may well be at the beginning of a new Golden Age." Amen. Keep 'em coming!


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Welcome to BTT Voice & Data
BTT has been operating in the business communications industry for over 20 years. During this time we have assisted in implementing changes to the working practices of many small, medium and large organisations and have gained a great deal of knowledge and experience in the way that various organisations operate.
We design business communications solutions to match a company's current needs but that have the flexibility to match future needs too. BTT strives to provide the highest quality installations with the most consistent and reliable service within our industry.


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- About CPKN
- Course Catalogue
- Register
- Learning Solutions
- CPKN Model
- News
- Support
Course Catalogue
Seized Firearms Safety
- Course Category:
NOTE: At the present time, you must launch this course using either IE11 or Edge Browsers. The course does not function correctly in Chrome.
Whether conducting searches, seizures, routine investigations, border checks, preparing court room exhibits, or entering/ admitting evidence, the safe handling of firearms is your responsibility. Safely handling firearms in the course of your duties will simplify your work, increase efficiency, and improve your ability to function with firearms -- it may even save your life!
Seized Firearms Safety is an interactive e-learning tool designed to instruct on basic firearm safety in accordance with the Canadian Firearms Program's Canadian Firearms Safety Course. This course will develop recognition of firearm types and actions and will provide operational knowledge to allow you to unload and "prove-safe" most of the firearms you will encounter.
** This course contains extensive video content. A high speed internet connection is recommended for optimal viewing and performance. **
Learning Objectives
Upon completion of this course you will be able to:
- Recall the acronyms of ACTS and PROVE as prescribed by the Canadian Firearms Safety Course
- Define firearm and differentiate between muzzle loading and breech loading firearms
- Identify firearm types
- Identify the major assemblies of a firearm and their corresponding parts
- Identify the common firearm actions
- Understand the purpose of the action components
- Understand the evolution of muzzle loading ignition systems
- Identify muzzle loading ignition systems for Matchlock, Wheel-lock, Flintlock, Percussion and Electronic ignition
- Identify the component parts of Flintlock, Percussion, In-Line Percussion and Electronic single barrel muzzle loading actions as well as Percussion Revolvers
- Unload different firearm types and actions while observing the acronyms of ACTS/PROVE
- Explain the requirements of the Firearms Act and its supporting regulations with regard to the safe storage, transportation, and display of Non-Restricted, Restricted and Prohibited firearms
Target Audience
This course is designed for all police, law enforcement and other government professionals who handle firearms in the course of their duties.
Content Provider
Content for this course was developed by the RCMP's Canadian Firearms Program.
|The development of this course was funded by the
Government of Canada's Sector Council Program.
Price: $25.00
Content Provider: RCMP - Canadian Firearms Program
Language: English / French
Length: 3 hours
Release Date: 2012-07-13


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Open-File Report 20071025
Open-File Report 20071025
By Laurence E. Schemel and Marisa H. Cox
A preliminary investigation of temporal and spatial variations in floodwater chemistry was conducted during winter and spring 1998 in the Yolo Bypass floodplain of the Sacramento River system. Samples were collected at locations along the eastern margin of the floodplain over the duration of the study and across the floodplain during major periods of inundation. Specific conductance and dissolved organic carbon concentrations along the eastern margin of the Yolo Bypass varied inversely with discharge. The Sacramento River was the greatest source of discharge to the floodplain during major periods of inundation. Increases in specific conductance and dissolved organic carbon were observed along the eastern margin during periods of lower discharge, when local streams accounted for a significant fraction of the total discharge through the Yolo Bypass. Apparent influences of local stream discharges also were observed in surface waters near the western margin of the floodplain during major periods of inundation. Although river and local stream sources of suspended particulate matter appeared important, in-floodplain processes were likely contributors to temporal and spatial variability in concentrations. Values for the C:N ratio of the particulate matter were lowest during periods of decreasing and low discharge through the floodplain, indicating production of phytoplankton in floodplain waters or supply to the floodplain by local stream sources. Phytoplankton discharged from the Yolo Bypass was detected by chlorophyll a monitors downstream in the Sacramento River during this study.
Summary and general findings useful in planning subsequent studies
References Cited
This report is available online in Portable Document Format (PDF). If you do not have the Adobe Acrobat PDF Reader, it is available for free download from Adobe Systems Incorporated.
Document Accessibility: Adobe Systems Incorporated has information about PDFs and the visually impaired. This information provides tools to help make PDF files accessible. These tools convert Adobe PDF documents into HTML or ASCII text, which then can be read by a number of common screen-reading programs that synthesize text as audible speech. In addition, an accessible version of Acrobat Reader 8.0 for Windows (English only), which contains support for screen readers, is available. These tools and the accessible reader may be obtained free from Adobe at Adobe Access.
Send questions or comments about this report to the authors, L.E. Schemel, (650) 329-4436 and M.H. Cox, (650) 329-4345.


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Subtotal: $0.00
It's not to earthy nor too sweet! Stacy says "I made this a week ago and just uncapped it. I'm still swooning!"
Summer Garden
Amidst a cool, green garden, the scent of heirloom roses and ripe, juicy strawberries drift by on a fine summer's breeze.
Red Velvet
Okay... if red velvet got to choose what it could smell like, it would smell like this!
There is something wistful, childlike, yet powerful in this blend. It stirs the emotions and brings glimmers of pleasant, long forgotten memories.
Vintage Lace
What an uncommon blend, I know, but they meld so beautifully. Rich, lots of depth. Patchouli and Earth Musk place the Almond into submission.
Drifting Dreams
If this one does not make you feel dreamy and optimistic, and you catch yourself smiling with whatever it evokes in you, then you have forgotten how to dream!
We're a friendly group who love social media. See you 'round the web!
Quantity: 1


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More birds under threat of habitat loss in Europe
…help Proact fight the latest short-sighted plansTwo more threats of habitat loss in Europe need your help - see below for details and how to help by joining the Proact campaigns.Dupont`s Lark Habitat at Risk - Timoneda D`Alfes, CataloniaAn appeal has for support has been received from Proact members and conservationists in Catalonia. The steppe habitat of Timoneda D`Alfes, thelast of its kind in the region, and home of rare breeding birds such as Dupont`s Lark Chersophilus duponti, the Lesser Grey Shrike Lanius minor and the Pin-tailed Sandgrouse Pterocles alchata is in danger of beingdestroyed by proposals to build a modern regional airport on the site of a grass strip flying club aerodrome. Other flora and fauna, also endangered onan Iberian and Europen level, are also at stake. Now read on …Timoneda d`Alfes is the only site in Catalonia where Dupont`s Lark still breeds, a stronghold of the eastern Iberian population. The number of breeding pairs has decreased alarmingly from 40-60 pairs in 1990 to less than 20 pairs in 2001. This decrease is due to aircraft activity, habitat loss and other local problemsAnother endangered bird breeding here is the Lesser Grey Shrike Lanius minor. Of the 2 traditional Catalan breeding sites one, the Empora marshes held NO breeding pairs last year due to habitat disturbance; in the other, Lleida, 7 pairs bred in 2002 - 37% of the whole Catalan breeding population. The Pin-tailed Sandgrouse Pterocles alchata also also breeds in the area with a total of 60 breeding pairs for in Catalonia in 2000 (in the 1980`s there were 180 breeding pairs.)Other steppe dwellers which breed here include the Calandra Lark Melanocorypha calandra, Short-toed Lark Calandrella brachydactyla and the Thekla Lark Galerida theklae. In the vicinity other interesting species such as the Great Spotted Cuckoo Clamator glandarius also breed.The Threat
The grass airstrip and ground facilities of the former military aerodromesituated in the Timoneda d`Alfes was taken into use a few years ago by the Royal Lleida Flying Club. Local politicians now plan to develop the site for business and tourist traffic which would include asphalting and extending the runway, building new hangars and generally transforming the aerodrome into a fully functioning regional airport.This would have a devastating effect on all wildlife in Timoneda D`Alfes; but in particular on the Dupont`s Lark. In June 1998 the Catalan government introduced a special plan for protecting the site, stating that the use of the aerodrome was provisional and including it in the list of natural interesting sites, (PEIN) which it had initiated in 1985. The special protection was afforded because of the site`s high ecological value because of the rare breeding birds.Catalan conservationists have protested for some time about the airport proposals, which would endange bird species protected under both Catalan and European law.
How can you help?
Catalan conservationists have appealed for help, in what could be the final stages of the public protest campaign. The deadline for public objections against developments plans for the airport is the 28th March 2003. A Proact campaign, with prepared draft texts and contact addresses is at: http://www.proactnow.org/localcampaigns/id23.html The Catalonians will be grateful for your support.The Last European Primeval Lowland Forest Fights for SurvivalAlthough the forests have been under protection since the end of the 14th Century, and were designated a World Heritage Site in 1992, increased economic pressures in the former Soviet republic of Belarus, such as soaring inflation and lack of funding create pressures to intensify commercial and economic activity. The natural regeneration of the forest is being irreversibly destroyed through intensive logging and skidding of timber. As in the Polish part of the biosphere reserve (the Bialowieza National Park) between 170 and 200 bird species breed here with owls and woodpeckers among the specialities. The owl species present include Eagle Owl Bubo bubo, Ural Owl Strix uralensis, Pygmy Owl Glaucidium passerinum and Tengmalm`s Owl Aegolius funereus and the rare Great Grey Owl Strix nebulosa is present some years. Hawk Owl Surnia ulula and Snowy Owl Nyctea scandiaca have also been recorded as vagrants.Belarus conservationists have appealed for international support in their campaign against this irreversible rape of an important European natural resource. Help them by going to http://www.proactnow.org/ppsi/id27.html and joining the international protest…
4th July 2014


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Drake Cancels European Tour
Due to his mother's surgery
NME reports that Drake has canceled a planned European tour because of his mother's health. In a statement, the world-conquering rapper says, "Despite my best hopes, it is apparent that my mother will need surgery earlier than anticipated. In light of this news, I have made the difficult decision to cancel my European tour in order to support her during her recovery, just as she supported me through the years. I cannot thank my European fans enough and look forward to performing abroad soon. I ask everyone to please respect my family's privacy during this time."
Drake talked a bit about his mother being sick in a recent MTV documentary, but he didn't reveal what her ailment was. On his Twitter yesterday, he wrote: "Back at my moms house...please include her in your prayers tonight as tmrw she faces a true challenge."
Drake will miss sets at some big festivals, including this weekend's Hove and Roskilde fests. Those canceled dates are listed below, as well as North American dates in July and August that are still on.
07-02 Tromøy, Norway - Hove Festival
07-03 Roskilde, Denmark - Roskilde Festival
07-04 London, England - Wireless Festival
07-05 Paris, France - La Cigale
07-07 Amsterdam, Netherlands - Paradiso
07-08 Liege, Belgium - Les Ardentes Festival
07-09 Naas, Ireland - Oxegen Festival
07-10 Balado, Scotland - T In the Park
07-12-13 London, England - O2 Shepherds Bush Empire
07-21 Winnipeg, Manitoba - Centennial Concert Hall
07-23 Saskatoon, Saskatchewan - Credit Union Centre
07-24 Edmonton, Alberta - Edmonton Event Centre
07-25 Calgary, Alberta - Big Four Building
07-27 Vancouver, British Columbia - The Centre in Vancouver for Performing Arts
08-01 Toronto, Ontario - Molson Canadian Amphitheatre (OVO Fest)
08-13 Indianapolis, IN - Hoosier Lottery Grandstand


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Saturday, November 11, 2017
Today has been a day of travelling – a 2 hour flight to Madrid to pick up a nine and a half hour flight to Panama city.
When Pope Francis announced the next World Youth Day was going to be in Panama we all collectively asked "Where?". First impressions of Panama City are wow! This place is full of impressive sky scraper buildings and surrounded by the ocean, it reminds me of Miami. The people are incredibly friendly and go out of their way to make you feel at home.
There are many familiar food chains, Burger King, Subway, Pizza Hut etc. alongside some more traditional restaurants.
Panama is 5 hours behind the UK and my body has no idea what time it is right now. The accommodation is really comfortable and I have had no trouble sleeping on the huge bed. There is air-conditioning in the bedroom, which is helpful as it is 30 degrees outside and Panama City has 85% humidity!
I have no idea what we are going to find today as we get to know this Catholic country (85% catholic population) a bit more. We are on the hunt for great accommodation for our group, the elusive World Youth Day Panama HQ and the Catholic Cathedral. Wish us luck!


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Hi all
Has anyone been able to get any of these? I had two preorders with two dealers ID toys and Tosche traders since May for complete sets.
I had an e mail from Tosche in the week saying that the entire run had been snapped up by American dealers, and Hasbro advised them that they would fulfill the order in the Autumn when they do another production run.
I presume that the wave 2 figures that are currently going for silly money on eBay had been preordered from dealers in the US.
It looks like another 3 month wait, if I am lucky".