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- The report contains detailed information about James River Coal Co. that gives an unrivalled in-depth knowledge about internal business-environment of the company: data about the owners, senior executives, locations, subsidiaries, markets, products, and company history.
- Another part of the report is a SWOT-analysis carried out for James River Coal Co.. It involves specifying the objective of the company's business and identifies the different factors that are favorable and unfavorable to achieving that objective. SWOT-analysis helps to understand company's strengths, weaknesses, opportunities, and possible threats against it.
- The James River Coal Co. financial analysis covers the income statement and ratio trend-charts with balance sheets and cash flows presented on an annual and quarterly basis. The report outlines the main financial ratios pertaining to profitability, margin analysis, asset turnover, credit ratios, and company's long-term solvency. This sort of company's information will assist and strengthen your company's decision-making processes.
- In the part that describes James River Coal Co. competitors and the industry in whole, the information about company's financial ratios is compared to those of its competitors and to the industry. The unique analysis of the market and company's competitors along with detailed information about the internal and external factors affecting the relevant industry will help to manage your business environment. Your company's business and sales activities will be boosted by gaining an insight into your competitors' businesses.
- Also the report provides relevant news, an analysis of PR-activity, and stock price movements. The latter are correlated with pertinent news and press releases, and annual and quarterly forecasts are given by a variety of experts and market research firms. Such information creates your awareness about principal trends of James River Coal Co. business.
About James River Coal Co.
James River Coal Company, through its subsidiaries, engages in mining, processing, and selling bituminous, steam, and industrial-grade coal in eastern Kentucky and southern Indiana. As of December 31, 2009, the companys 6 mining complexes included 14 underground mines, 10 surface mines and 10 preparation plants, 5 of which have integrated rail loadout facilities and 3 of which use a common loadout facility at a separate location.
Mining Operations
The companys coal production is conducted through five mining complexes in the Central Appalachia Region and one mining complex in the Midwest Region.
Bell County: The Bell County complex is located in Bell County in eastern Kentucky. The company uses room and pillar mining and mines the Jellico and Garmedia seams of coal. Coal is processed at its preparation plant and loaded into railcars via an integrated four-hour unit train loadout that is serviced by both the CSX and Norfolk Southern railroads.
Bledsoe: The Bledsoe complex is located in Leslie and Harlan counties in eastern Kentucky. The company uses room and pillar mining and mines the Hazard #4 and #4 Rider seams of coal at this complex. Coal is processed at one of two preparation plants and loaded into railcars at a separate location via a four-hour unit train loadout on the CSX railroad.
Blue Diamond: The Blue Diamond is located in Leslie, Perry and Letcher counties in eastern Kentucky. The company uses room and pillar mining for its underground mine and uses the contour and highwall method for its surface mine. The company mines the Hazard #4 and Elkhorn #3 at this complex. Coal is processed at its preparation plant, and loaded into railcars via an integrated four-hour unit train loadout on the CSX railroad.
Leeco: The Leeco is located in Knott and Perry counties in eastern Kentucky. The companys underground mines use room and pillar mining and its surface mine uses the contour and highwall mining methods. The company mines the Amburgy seam of coal and the Hazard #4, #5, #6, #7, #8 and #9 seams at this complex. Coal is processed at its preparation plant and loaded into railcars via an integrated four-hour unit train loadout on the CSX railroad.
McCoy Elkhorn: The McCoy Elkhorn complex is located in Pike and Floyd counties in eastern Kentucky. The companys underground mines use room and pillar mining and its surface mine uses the contour mining methods. The company mines the Millard, Elkhorn #2 and Elkhorn #3 seams at this complex. Coal is processed at one of its two preparation plants and loaded into railcars via integrated four-hour unit train loadouts on the CSX railroad.
Triad: The Triad is located in Pike and Knox counties in southern Indiana. The company uses room and pillar mining to mine the Springfield seam of coal, and use the surface mine method to mine multiple seams, including the Danville, Millersburg, Hymera, Bucktown and Springfield seams. Coal is processed at one of three active preparation plants and loaded into trucks for delivery to the customer or by rail at its Switz City loadout. The Switz City loadout is serviced by Indiana Railroad and the Indiana Southern Railroad. The company is primarily responsible for the reclamation activities involved with all contractor-operated mines.
The companys major customers include Georgia Power Company and South Carolina Public Service Authority
James River Coal Company was founded in 1988.
The above Company Fundamental Report is a half-ready report and contents are subject to change.
It means that we have all necessary data in our database to prepare the report but need 2-3 days to complete it. During this time we are also updating the report with respect to the current moment. So, you can get all the most recent data available for the same price. Please note that preparation of additional types of analyses requires extra time.
1.1. Key facts
1.2. Financial Performance
1.3. Key Executives
1.4. Ownership and Major Holders
1.5. Company History
2.1. Business Description
2.2. Major Products and Services
2.3. Markets and Sales Activities
2.4. Locations, Subsidiaries, Operating Units
3.1. Overview
3.2. Strengths
3.3. Weaknesses
3.4. Opportunities
3.5. Threats
4.1. Financial Statements
4.1.1. Income Statement
4.1.2. Balance Sheet
4.1.3. Cash Flow
4.2. Financial Ratios
4.2.1. Profitability
4.2.2. Margin Analysis
4.2.3. Asset Turnover
4.2.4. Credit Ratios
4.2.5. Long-Term Solvency
4.2.6. Growth Over Prior Year
4.2.7. Financial Ratios Charts
4.3. Stock Market Snapshot
5.1. James River Coal Co. Direct Competitors
5.2. Comparison of James River Coal Co. and Direct Competitors Financial Ratios
5.3. Comparison of James River Coal Co. and Direct Competitors Stock Charts
5.4. James River Coal Co. Industry Analysis
5.4.1. Energy Industry Snapshot
5.4.2. James River Coal Co. Industry Position Analysis
6.1. News & PR Activity Analysis
6.2. IR Corporate News
6.3. Marketing News
6.4. Corporate Events
7.1. Experts Opinion
7.2. Experts Estimates
9.1. Political Factors
9.2. Economic Factors
9.3. Social Factors
9.4. Technological Factors
9.5. Environmental Factors
9.6. Legal Factors
10.1. Internal Factor Evaluation Matrix
10.2. External Factor Evaluation Matrix
10.3. Internal External Matrix
James River Coal Co. Key Facts
Management Effectiveness
Income Statement Key Figures
Balance Sheet Key Figures
Cash Flow Statement Key Figures
Financial Performance Abbreviation Guide
James River Coal Co. Key Executives
Key Executives Biographies1
Key Executives Compensations1
James River Coal Co. Major Shareholders
James River Coal Co. History
James River Coal Co. Products
Revenues by Segment
Revenues by Region
James River Coal Co. Offices and Representations
James River Coal Co. SWOT Analysis
Yearly Income Statement Including Trends
Income Statement Latest 4 Quarters Including Trends
Yearly Balance Sheet Including Trends
Balance Sheet Latest 4 Quarters Including Trends
Yearly Cash Flow Including Trends
Cash Flow Latest 4 Quarters Including Trends
James River Coal Co. Profitability Ratios
Margin Analysis Ratios
Asset Turnover Ratios
Credit Ratios
Long-Term Solvency Ratios
Financial Ratios Growth Over Prior Year
James River Coal Co. Capital Market Snapshot
James River Coal Co. Direct Competitors Key Facts
Direct Competitors Profitability Ratios
Direct Competitors Margin Analysis Ratios
Direct Competitors Asset Turnover Ratios
Direct Competitors Credit Ratios
Direct Competitors Long-Term Solvency Ratios
Energy Industry Statistics
James River Coal Co. Industry Position
Company vs. Industry Income Statement Analysis
Company vs. Industry Balance Sheet Analysis
Company vs. Industry Cash Flow Analysis
Company vs. Industry Ratios Comparison
James River Coal Co. Consensus Recommendations1
Analyst Recommendation Summary1
Price Target Summary1
Experts Recommendation Trends1
Revenue Estimates Analysis1
Earnings Estimates Analysis1
Historical Surprises1
Revenue Estimates Trend1
Earnings Estimates Trend1
Revenue Revisions1
James River Coal Co. Annual Revenues in Comparison with Cost of Goods Sold and Gross Profit
Profit Margin Chart
Operating Margin Chart
Return on Equity (ROE) Chart
Return on Assets (ROA) Chart
Debt to Equity Chart
Current Ratio Chart
James River Coal Co. 1-year Stock Charts
James River Coal Co. 5-year Stock Charts
James River Coal Co. vs. Main Indexes 1-year Stock Chart
James River Coal Co. vs. Direct Competitors 1-year Stock Charts
James River Coal Co. Article Density Chart
1 – Data availability depends on company's security policy.
2 – These sections are available only when you purchase a report with appropriate additional types of analyses.
The complete financial data is available for publicly traded companies.
SWOT Analysis
SWOT, which stands for Strengths, Weaknesses, Opportunities and Threats, is an analytical framework that identifies the internal and external factors that are favorable and unfavorable for a company.
Enhanced SWOT Analysis
Enhanced SWOT is a 3×3 grid that arranges strengths, weaknesses, opportunities and threats into one scheme:
- How to use the strengths to take advantage of the opportunities?
- How to use the strengths to reduce likelihood and impact of the threats?
- How to overcome the weaknesses that obstruct taking advantage of the opportunities?
- How to overcome the weaknesses that can make the threats a reality?
Upon answering these questions a company can develop a project plan to improve its business performance.
PESTEL Analysis
PESTEL (also termed as PESTLE) is an ideal tool to strategically analyze what influence different outside factors – political, economic, sociocultural, technological, environmental and legal – exert on a business to later chart its long term targets.
Being part of the external analysis when carrying out a strategic assessment or performing a market study, PESTEL gives an overview of diverse macro-environmental factors that any company should thoughtfully consider. By perceiving these outside environments, businesses can maximally benefit from the opportunities while minimizing the threats to the organization.
Key Factors Examined by PESTEL Analysis:
- Political – What opportunities and pressures are brought by political bodies and what is the degree of public regulations' impact on the business?
- Economic – What economic policies, trends and structures are expected to affect the organization, what is this influence's degree?
- Sociological – What cultural and societal aspects will work upon the demand for the business's products and operations?
- Technological – What impact do the technological aspects, innovations, incentives and barriers have on the organization?
- Environmental – What environmental and ecological facets, both locally and farther afield, are likely to predetermine the business?
- Legal – What laws and legislation will exert influence on the style the business is carried out?
IFE, EFE, IE Matrices
The Internal Factor Evaluation matrix (IFE matrix) is a strategic management tool helping audit or evaluate major weaknesses and strengths in a business's functional areas. In addition, IFE matrix serves as a basis for identifying and assessing relationships amongst those areas. The IFE matrix is utilised in strategy formulation.
The External Factor Evaluation matrix (EFE matrix) is a tool of strategic management that is typically utilised to assess current market conditions. It is an ideal instrument for visualising and prioritising the threats and opportunities a firm is facing.
The essential difference between the above mentioned matrices lies in the type of factors incorporated in the model; whilst the latter is engaged in internal factors, the former deals exceptionally with external factors – those exposed to social, political, economic, legal, etc. external forces.
Being a continuation of the EFE matrix and IFE matrix models, the Internal External matrix (IE matrix) rests upon an investigation of external and internal business factors integrated into one suggestive model.
Porter Five Forces Analysis
The Porter's five forces analysis studies the industry of operation and helps the company find new sources of competitive advantage. The analysis surveys an industry through five major questions:
- What composes a threat of substitute products and services?
- Is there a threat of new competitors entering the market?
- What is the intensity of competitive rivalry?
- How big is the bargaining power of buyers?
- How significant is the bargaining power of suppliers?
VRIO Analysis
VRIO stands for Value, Rarity, Imitability, Organization. This analysis helps to evaluate all company's resources and capabilities and bring them together into one aggregate table that includes:
- Tangible resources
- Financial
- Physical
- Technological
- Organizational
- Intangible resources
- Human
- Innovation and Creativity
- Reputation
- Organizational capabilities
The result of the analysis gives a clear picture of company's competitive and economic implications, answering the questions if the resources mentioned above are:
- Valuable?
- Rare?
- Costly to imitate?
- Organized properly?


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COLUMBUS, Ohio—A man accused of stabbing four people at a downtown building last year in an attack that sent dozens scrambling for safety and ended when a police officer shot the suspect was found not guilty Monday by reason of insanity.
Defendant John Mallett also was ordered sent to a Columbus forensic psychiatric facility under the ruling by Franklin County Judge Kimberly Cocroft.
The March 2012 attacks appeared to be a random assault on people inside and outside a downtown Columbus trade school.
According to an aunt whom Mallett had moved in with after arriving in Columbus, Mallett was frustrated that his plans to move into his own place were delayed because an apartment wasn't ready.
Messages were left with Mallett's public defender Monday seeking comment. Mallett had previously pleaded not guilty by reason of insanity to five counts of attempted murder and five counts of felonious assault.
Mallett, 39, was armed with three knives when he entered a building that houses Miami-Jacobs Career College and other offices and stabbed four men, the first a college employee, police said at the time. Other people intervened and took away a knife Mallett was using but they didn't realize he had more, police said. A Columbus police officer responding to reports of the attack shot Mallett several times.
The Monday verdict was not unexpected. Previous court filings had raised the issue of Mallett's mental health. One such filing, by an attorney representing one of the victims, alleged Mallett was in and out of mental health facilities and jails until Jan. 6, 2012, when he was placed on a Greyhound bus and sent to Columbus from Tennessee.
Mallett suffered from severe mental illness including schizophrenia and was prone to "violent assaultive outbursts" when living in Tennessee before coming to Columbus in January 2012, according to that January filing by a lawyer for victim Jeffrey Maloon.
Maloon's attorney had sought copies of Mallett's health records to determine whether mental health providers in Ohio or Tennessee could be sued over their treatment of Mallett. Cocroft denied the request.
Andrew Welsh-Huggins can be reached on Twitter at https://twitter.com/awhcolumbus.

subset: commoncrawl


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The Choken Bako is a unique bank that has a robotic dog trying to devour the coins you drop into the bank. The pooch enthusiastically goes for the money you put in the bowl, and drops it into the box beneath.
There are many different types of piggy banks, but the Choken Bako hungry dog is a cute way to save up your money during this economic crisis.
Check out the video of the Choken Bako to see how the pup collects coins.
Coin Collecting Canines
More Stats +/-
15 Peculiar Piggy Banks
Taxidermy Piggy Banks
Swank Piggy Banks
DIY Breakable Banks
Chewing Coin Collectors
The Choken Bako Bank Has a Robotic Money Hungry Dog
- By: Tisah TucknottAug 6, 2009
References: japantrendshop & inewidea
References: japantrendshop & inewidea


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With all the smartphone options on the market today, I thought I'd dedicate some special Top 3 Tuesday time to discuss reasons to choose BlackBerry® smartphones. I've been talking to a lot of BlackBerry fans recently about why they picked BlackBerry smartphones to be their device of choice, and there are three simple (yet powerful!) reasons that come up time and time again. With these testimonials in mind, here are the three most popular reasons to choose BlackBerry.
Connected: BlackBerry smartphones have some unique and powerful messaging applications that help keep you connected to what matters most to you. BlackBerry® Messenger (BBM™) and email functions are the obvious examples here – and they're designed to make communicating quick, easy and in the moment – but there are subtle nuances that make a big impact in sharing what's important to you, too. Apps can be designed to be socially connected — not only between contacts, but with other apps as well. This makes it simple for you to share what game you're playing, to chat about the sport scores of your favorite team, or update your social networks – all from within the app you're already using and designed to be efficient and seamlessly connected. Your BlackBerry smartphone keeps your fingers on the pulse of your networks, your business and your loved ones.
Productive: People have been saying this for years, and it's still true today –BlackBerry smartphones help you get things done. Whether it's answering emails, editing documents, or even planning travel, the system is designed to help you easily navigate and be efficient. For those interested, the Inside BlackBerry Help Blog has got a ton of tips and shortcuts for you to check out, but that's just the beginning. There are a ton of apps that come built-in (or are available to download for free) that are designed to make you more productive. An example of this is BlackBerry® Mobile Conferencing, which is designed to save you time. Once you activate the app permissions, the app will automatically pull out conference call numbers from your appointments to create a "Join Now" button that allows you to dial in with one click. Another good example is BlackBerry® Traffic, which is designed to find and display the fastest route to your destination — including the option of notifying your key contacts with your estimated time of arrival.
But my personal favorite productivity feature is something as simple as Universal Search. Simply start typing what you want to find, and it automatically presents you with items on your phone, in your applications and beyond to things like search engines or media service apps. It saves you time, and in the end, that leaves you with time to do more in your everyday life.
[ YouTube link for mobile viewing ]
Choice and value: Everyone on Team BlackBerry is an individual — no two BlackBerry smartphone users are the same. There are many distinct lines of BlackBerry smartphones designed to offer you choices best suited to your personal preferences. For keyboard lovers, there are the BlackBerry® Bold™ smartphones and BlackBerry® Curve™ smartphones, but there's also the BlackBerry® Torch™ line of smartphones designed to offer larger touchscreen experiences. There are different models in each line to match your needs and your budget, each of them offering exceptional value for what's included out of the box in terms of accessories and built-in or free to download apps.
BlackBerry smartphones are also designed to provide ongoing value through exceptional data handling and efficiency as well. This is designed to help you by keeping your smartphone usage costs at a manageable level. For those of you in a monthly contract, think of how much you could save over the life of your term!
There you have it: three great reasons to choose BlackBerry smartphones. Why did you pick BlackBerry? Tell me below in the comments.


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2016 Gage Summer Classroom Locations
Please look below to find your class's room #! If your class is not listed yet or says "TBD", we will have the information posted soon.
ROOM 101 Create Image Thru Collage Noah Sat-Sun 8/20-8/21 9:30am-4:30pm
OFFSITE Hike & Draw: Seward Park Bixler Sat 8/27 9:30am-4:30pm
ROOM 308 Figure Structure Drawing Flack Mon-Fri 8/29-9/2 9:30am-4:30pm
ROOM 200 Beginning Acrylic Paint Furchgott Tue-Thu 8/30-9/1 9:30am-4:30pm
OFFSITE Landscape Ptg: Hood Canal Faigin Wed-Fri 9/7-9/9 9:30am-4:30pm


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Please choose from the options above to see price and availability.
This matted framed art piece features a colorful map of Washington D.C.
Art and design were always Michael's favorite subjects at school. He was fortunate to land a job as a graphic designer at one of London's most prestigious publishing companies after leaving University. After 12 highly enjoyable years Michael Tompsett made the decision to pursue a full-time career creating his own work. The freedom and time to be able to focus solely on his own projects has been a wonderful experience. Although Michael likes to experiment with different styles and subjects, his main focus is on map art. He enjoys looking for unique and interesting ways to depict something which is very familiar. Maps are visual representations of the world we live in, a world which is incredibly diverse. Apart from maps, Michael Tompsett creates urban landmark and cityscape designs.
11x14 Size is an 8x10 giclee print under acrylic in a 11x14 black frame. 16x20 Size is an 11x14 giclee print under acrylic in a 16x20 black frame. Giclee (jee-clay) is an advanced printmaking process for creating museum quality fine art reproductions.


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Gastroenterology Research and Practice
Volume 2012, Article ID 756263, 6 pages
The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran
1Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2Gastrointestinal and Liver Diseases Research Center (GLDRC), Razi Hospital, Guilan University of Medical Sciences, Sardar-Jangle Avenue, P.O. Box 41448-95655, Rasht, Iran
3Genomics & Animal Department, Agricultural Biotechnology Research Institute of North Region, Rasht, Iran
Received 15 May 2012; Revised 9 September 2012; Accepted 14 October 2012
Academic Editor: Akira Andoh
Copyright © 2012 Masoumeh Faghani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran. Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers. Results. MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instability positive and 77.1% (74 patients) were microsatellite instability negative. The highest rate of MSI (40.9%) was found in the rectal region. MSI-H status was seen more frequently in distal tumors (, odds ratio = 3.13, 0.96–10.14). Conclusions. Distal tumor location and MSI may associate with special clinicopathological features. It seems that there may be correlation with underlying genetic and immunologic mechanisms.
1. Introduction
Colorectal cancer (CRC) is one of the major public health problems in the world. CRC is one of the most common forms of cancer in western countries [1] and is the third most common cancer in males and the second in females [2]. Incidence of colorectal cancer in Iran's general population is between 7 and 8/100,000 in both men and women [3]. Incidence of CRC in Iran was lower than that of the western countries and is increasing in recent years [4].
Most of CRCs are sporadic, but 5% to 10% of colorectal cancers are associated with a primary genetic factor [5, 6]. Hereditary nonpolyposis colorectal cancer (HNPCC), the most common syndrome, is secondary to an inherited mutation in one of the DNA mismatch repair (MMR) genes (hMLH1, hMSH2, hMSH6, and hPMS2). Tumor classification is historically based on molecular features (e.g., microsatellite instability-high status (MSI-high) versus microsatellite stable (MSS)) [5, 6]. Failure of the DNA MMR system such as inactivation and mutation of MMR genes, mostly hMLH1 and hMSH2 that occur during the replication of DNA, causes MSI [7]. MSI is alteration in the length of simple, repetitive microsatellite sequences that occur throughout the whole genome [8].
MSI is detected in about 15% of all colorectal cancers [7] three percent of these are associated with Lynch syndrome and the other 12% are related with CpG island methylator phenotype (CIMP). CRC with MSI has particular characteristics such as improved survival rates and better prognosis than MSS tumors [9]. They also have distinct sensitivity to the action of chemotherapy [10]. On the other hand, MSI tumors may interfere in cancer genesis pathways and this may cause similar clinical outcomes. There is evidence that MSI tumors have common features, and MSI cancers that arise in the proximal colon have frequently low differentiated in pathology diagnosis and in general have an improved prognosis compared with MSS colorectal cancers [11–13].
These strong biological associations make MSI a useful genetic marker in patients with colorectal cancer. Therefore, we decided to evaluate the relationship between MSI and sporadic CRC in the northern part of Iran.
2. Patients and Methods
The sample included 96 specimens of sporadic colorectal adenocarcinoma and the corresponding adjacent cancer-free tissues from the north part of Iran (Rasht). Cases were selected from the Department of Pathology between February 2007 and December 2009 at the Razi and Poursina hospitals of Guilan University of Medical Sciences. Sporadic CRCs by definition are the patients who have no family history of cancer in first or second degree related families.
Prior to commencement of the study, all patients provided informed consent and the study was approved by our institutional ethics committee. Data collected from main charts and taking the history of patients included the presence or absence of lymph node metastases, tumor size and grade, patient age, and sex. The tumors classified "proximal" were from the cecum, hepatic flexure, ascending colon, and transverse colon, whereas "distal" tumors were from the splenic flexure, descending colon, sigmoid colon, and rectum.
MSI-H status was determined by PCR of genomic DNA that is isolated from paraffin-embedded normal and tumor tissues from each patient. Paraffin-tissue sections were deparaffinized in xylene then digested with proteinase K (2 mg/mL) overnight at 55°C. Using High Pure PCR Template Preparation DNA isolation kit (Roche, Germany), genomic DNA was extracted from samples, according to manufacturer's instructions. We used BAT-26 and BAT-25 markers because mononucleotide loci BAT-25 and BAT-26 have more than 90% sensitivity for detecting MSI by themselves; these markers are readily analyzed with routine staining methods as well as by PCR-SSCP [14, 15]. Between 50 to 100 nanograms of DNA was used as a template in a 25 μL PCR reaction mixture containing 1.5 μmol MgCl2, 1 U Taq polymerase (Sinagen, Iran), and 1 μmol either of the primer pairs (Kawsar Biotech Company, Iran). For negative control no added DNA was included in each run. Forward and reverse primer sequences were used to amplify the BAT-26 and BAT-25 as follows [16, 17].
Bat-26: 5′-TGACTACTTTTGACTTCAGCC-3′ and 5'-AACCATTCAACATTTTTAACC-3′.
BAT-25: 5′-TCGCCTCCAAGAATGTAAGT-3′ and 5′-TCTGGATTTTAACTATGGCTC-3′.
PCR amplification was performed for these markers as follows: 1 cycle (94°C for 5 min), 35 cycles (30 sec at 94°C, 60 sec at 45°C for BAT-26 and 60 sec at 53°C for BAT-25, 60 sec at 72°C), 1 cycle (72°C for 5 min). The PCR product was denatured into single-strand DNA by heating in a formamide loading buffer (95% formamide, 10 mM EDTA, 0.05% bromophenol blue, 0.05% xylene cyanol) for 5 min at 94°C and then separating on a minigel electrophoresis apparatus (Farayand Danesh, Iran) using nondenaturing 15% acrylamide (60 : 1, acrylamide : bisacrylamide) gels containing 5% glycerol [16]. Gels were run at ambient temperature and without cooling. Gels were run for 2.5 h at 90 V. Silver staining was carried out as previously described. MSI-H was defined by the presence in the tumor samples of our allele compared to the adjacent normal tissues.
3. Statistical Analysis
The analyses were performed by the SPSS (version 16). Categorical variables (sex, site, histological grade, PTN, and metastasis of tumor) were compared with the -test and Pearson chi-square test, and odds ratios (OR) were adjusted with 95% confidence intervals (95% CI). Continuous variables (age of recognized and size of tumor) were compared with the one-way ANOVA test. The Kolmogorov-Smirnov test (K-S test) was used for the equality of continuous variables. All values were two tailed and the statistical significance level was set to .
4. Results
This analysis included 96 sporadic colorectal adenocarcinomas and adjacent normal colorectal tissue. The age of our patients (54 males, 42 females) ranged from 27 to 85 years (mean 63.5).
The main clinicopathological features of the patients are summarized in Tables 1 and 2. The mean age was years in MSI positive patients and years in MSI negative ones. There was not a statistical correlation between MSI and the age of the patients (). Data analysis revealed 64.5% of sporadic CRCs samples located in distal or left colic (Table 3). The distribution of lymph node metastasis in distal CRCs was not statistically different with right CRC patients () (Table 2).
Analyze of all tumor tissue with MSI-H exhibited that all of these had a shortening of the poly (T) tract at BAT-25 and poly (A) tract at BAT-26. Data showed that all of the samples were heterozygous for these markers, which mean one allele within the normal range of repeat length. Silver stain PCR-SSCP analysis showed a specific PCR product of 124 and 121 bp for BAT-25 and BAT-26, respectively. Those cases with an unequivocally distinct additional band or shift in the tumor tissue DNA compared with normal tissue. MSI analysis revealed that 22 patients (22.9%) were MSI positive and 74 patients (77.1%) were MSI negative. The allelic frequencies for BAT-25 and BAT-26 were almost equivalent in our sample. Among our patients, 21 (21.9%) had alteration in BAT-26 marker, 20 (20.8%) had alteration in BAT-25 marker, and 18 (18.7%) had both alterations. Data showed that most of the tumors with MSI-H were located in the left colic region and the highest rate of MSI-H (40.9%) was found in the rectum. The prevalence of MSI-H in other anatomical regions of large intestine is showed in Table 3. There was a correlation between MSI-H and the site of tumor (, Odds ratio = 3.06, 0.96–10.14). There was no relationship between MSI-H and the size of the tumor (Table 1). A significant correlation was observed between site and size of tumor () (Table 2). In patients, 64.6% had lymph node metastases, and test showed a significant relationship between the sex and lymph node metastases (, OR = 2.81, 1.18–6.73).
5. Discussion
Microsatellites are repeated sequences that are highly susceptible to misalignment during replication, resulting in a 100-fold increase in their mutation rate [18]. These noncoding mono- and dinucleotide repeats are scattered in the genome, accumulate alterations in MMR-deficient tumors, and are used to assess the MSI phenotype [19]. Repeated sequences, most often mononucleotide tracts, exist in a number of human genes, such as hMSH6 and hMSH2. In fact, a number of these genes have shown to be altered in MSI+ colorectal tumors. Some mutations like insertion or deletion in microsatellite repeats regions cause MSI and these phenomena resulted from failure of the MMR system that edits errors made during DNA replication [17]. Data showed that MMR components participate in the recognition of DNA damage caused by alkylating agents, platinum-based drugs including those used in cancer chemotherapy [19]. Generally the tumors are classified as MSI+ tumors if instability is observed at a proportion of microsatellite loci (30%), but some authors consider that testing BAT-26 is almost adequate for MSI+ status [17]. So, detection of MSI, a functional marker of MMR defects, might be useful for determination of these defects [16].
On the other hand, there is evidence that MSI+ tumors have some significant biological and clinical importance [20, 21]. Some researchers believed that recognition of MSI can help us to understand the pathogenesis of cancer and is a useful thing in planning for prevention of cancer. Others showed that MSI should be important factor and may also be predictive of tumor responsiveness to certain chemotherapeutic drugs, such as alkylating agents and platinum-based drugs [22–26]. There are several studies in the literature investigating MSI in colorectal and other cancers at different loci by using different microsatellite markers [26]. In this study we used BAT-25 and BAT-26 markers to detect MSI-H tumors and we find that the ratios of these two markers are very similar to each other. We used silver staining method for detecting of MSI-H and it has been shown that silver stained SSCP gels can readily detect deletions of as little as 3 bp in BAT-26 [17]. This result was consistent with the previous study from Kim et al. [25], which reported that 67.3% of distal sporadic MSI-high CRCs and 94.2% of proximal MSI-high CRCs showed BAT-26 variation and 67.3% of distal sporadic MSI-high CRCs and 93% of proximal MSI-H CRCs showed BAT-25 variation. Our study result also revealed that 81.8% of total MSI-H had distal CRCs (Table 1). The distribution of Lymph node metastasis (LNM) was different in two groups (25.8% of proximal MSI-H CRCs and 74.2% of distal MSI-H CRCs had LNM).
Based on articles the rate of MSI in sporadic CRCs was 15–20% and these patients have deficiencies in DNA mismatch repair due to methylation silencing of the MLH1 gene [26, 27]. Recently, it has been shown that overexpression of hMSH2 or hMLH1 can induce apoptosis [28]. This may cause MSI+ sporadic CRCs to lose the ability to undergo efficient apoptosis. A total of 22.9% of the tumors in our study had MSI-H and as we pointed before all patients had no obvious family history. This is very different from results of similar studies in other countries such as Japan; Ichikawa et al. described that DNA variants of BAT-25 locus is very low in the Japanese population (as low as than 1%), but in African American people data showed that approximately 18.4% of African-Americans would be polymorphic at BAT-25 and 12.6% at the poly (A) tract at BAT-26 in 12.6% [29, 30]. This may show an ethnic difference in frequency of BAT-25 locus; in our study, a total of 20. 8% of CRCs had alteration in the size of BAT-25 marker.
In a previous study in Iran data showed that familiar clustering of colorectal cancer was located in the right side of the colon [31]. In our study most of sporadic CRCs samples were located in the left side of the colon (64.6%). In addition, the results of our study demonstrate that left colic MSI-H tumors must need a special attention than right MSI-H tumors. The first possible explanation for our results may by that 90.8% of left CRCs have pt3 and pt4 stages in pathological determination. Secondly in both right and left CRCs the degree of metastasis in MSI-H was higher than in MSS tumors (62.2 and 72.7% in right and left colic, resp.). However, in another study in Norway, one researcher demonstrated that proximal location of the tumor and MSI is related to a higher number of lymph nodes harvested [32]. A total of 64.58% of the patients in our study had lymph node metastasis which is very high compared to data from other countries at the time of the resection of tumor [32–35]. This difference may be due to a late diagnosis of cancer in Iran or the small sample size of our study. In contrast with Ansari et. al. article, most of our patients (80.2%) were above 50 years old [36].
In conclusion the results of this study indicate that left colic sporadic MSI-H tumors may have special clinicopathological features. Therefore recognition of MSI can help understand the pathogenesis and potentially plan screening and prevention of colorectal cancer. Future larger sample size population-based studies in other provinces of Iran are required to confirm the results of this study in Iranian people.
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Insurance - General in Yandina, QLD
The most popular Insurance - General near Yandina, QLD, 4561
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WFI offers insurance plans for businesses, farms, strata complexes and landlords. Specialising in providing insurance packages you can tailor to suit your requirements.more
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Elders Insurance Gympie provides professional General Insurance advice to clients in the Cooloola region, Mary Valley and the northern end of the Sunshine Coast. We established the business in 2002, and a number of our team are still with us from those early days. We pride ourselves on the principle that "people come first". We accommodate the needs of our clients by offering a service at their workplace or home, at our office or by phone. No matter whether your enquiry relates to the purchasing or renewing of a General Insurance policy or paying a claim, we manage everything.more
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And That's Entertainment
We want our patients to have the most home-like atmosphere possible. When friends and family visit, we want them to feel welcomed and comfortable. From the smell of buttery popcorn in the theater to the sound of laughter in the club room, our facilities are designed to provide all the comforts of home.
Movie Theater
Our theaters are reminiscent of days gone by…equipped with popcorn machines, special seating, and lighting designed to share a pastime with friends, families, and guests. We offer a selection of films and some theaters are also equipped with candy counters to enhance this experience.
Club Room
Our club rooms provide an opportunity for recreation, with options such as pool or game tables. These rooms welcome patients and provide a fun experience to enjoy with friends and family. We encourage all of our patients and guests to use our club rooms.
Children's Corner
Children's corners are set up with coloring books, toys, and other entertaining features so little ones can enjoy their time when visiting at our facilities.
Garden Room
Our garden rooms feature fountains, colorful greenery, and garden style seating, allowing patients to participate in the hobbies they enjoy in an outdoor-like atmosphere.
Speciality Shops / Bistro / Ice Cream Parlor
Our specialty shops, such as bistros and ice cream parlors, provide patients with a comfortable atmosphere and familiar experience to enjoy with their friends and family.
Quality of Life Amenities vary at each facility. Find a facility near you to learn more about available services.
Fine Dining
Enjoy your meals of the day in our fine dining setting, where you can choose what your appetite desires from the selections we offer. Our fine dining programs are designed to simulate the home or restaurant style dining to which our patients are accustomed. Our goal is to create a true dining experience by home style, buffet, or menu ordering dining.
Private Dining
Take pleasure in our private dining room to entertain guests and loved ones for special occasions.
Quality of Life Amenities vary at each facility. Find a facility near you to learn more about available services.
The spas are meant to provide a pleasant and relaxing bathing experience, including soft music and a calming atmosphere. Spas feature a water fountain, comfortable seating, and colorful greenery.
Physician's Office
Professional in appearance, physician offices are set up so that our patients can feel like they are visiting their doctors' offices. The space reflects our appreciation of the physician involvement in the patient's plan of care.
Our chapels offer patients, family members, guests, friends, and staff a comfortable, quiet place to worship, reflect, and pray.
Beauty Salon / Barber Services
Salons are set up to provide the atmosphere of a first class hair salon for a style and cut to your liking. Some salons offer manicures and pedicures and enhance the experience with relaxing music.
Quality of Life Amenities vary at each facility. Find a facility near you to learn more about available services.


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20% off sitewide. It's savings time, baby. Use BLUE20
A magnificent unicorn graces the artwork in all its glory. The words "Totally Straight" are eloquently written with a rainbow pattern.
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One reason to love KEXP is for our many in-studios. In 2007, KEXP featured over 400 in-studio guests. Already, it seems that 2008 is going to be huge! Yesterday, we hosted three bands — The Helio Sequence, the Campbell Brothers, and Orgone — and today we have Nada Surf at noon.
Be sure to check out these photos from yesterday (click the photos to view the slideshows):
The Helio Sequence — photos by Chona Kasinger
The Campbell Brothers — photos by Jim Beckmann
Tomorrow, MGMT will be live at 1PM and on Friday, Black Mountain also at 1PM.
Remember, you can go back to listen to recent in-studios on our 14-day Streaming Archive


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I'm always looking for new learning platforms, and I am wary about relying on a single course or lesson vendor to talk about on this blog.
Curious.com is part of a new breed of online education sites that allow experts in any topic (even you or me) to create and sell individual video lessons online. Similar to Udemy. But unlike Udemy, lessons start as low as $1 (and I've seen plenty at $2, $3, and $5 price points) whereas Udemy tends to advertise courses at $20, $100, $300 or more (with frequent discounts). So for $20 deposited, it seems like you can view a lot more variety of content on Curious.com than on Udemy.
Lessons on Curious are generally shorter, which is in line with the price points. For example, on Curious I watched a 4-minute video on how to create time-lapse photography for $1, whereas a basic 5-hour DSLR photography course on Udemy retails for $39. It's fair to say those two products are aimed at different audiences. (I couldn't find a "time-lapse photography" course on Udemy, as that's perhaps a lot too specific to be a full course.)
So on Curious, you can learn 1 specific thing for $1. That's a neat idea. Curious sells lessons, while Udemy sells courses.
Now on to the pros and cons with this platform:
- Lower starting price point
- Bite-sized content
- Learn a very specific thing instead of taking a whole multi-part course
- The free preview of each lesson covers half the lesson or more
- No clear track to learning an entire topic in a consistent manner (i.e. What if I wanted to learn Japanese? No single instructor does a full multi-hour course in the topic)
- Wide variety of quality between amateur teachers
- No quizzing, certification, or other artifact after taking
That's not to say the cons are knocks against the site. They clearly know the target of what they are trying to deliver, and they are not trying to compete against edX or Coursera to be a professional certification provider for higher education.
I took 9 lessons on the site. Some of the interesting lessons I watched were:
- How to Extract Strawberry DNA
- How to Count in Spanish
- Use a Chair to Improve at Pull-ups
- Never Lose at Tic-Tac-Toe
- Digital Camera Memory Card Basics
- How to Beatbox
Hate to repeat the pun, but I will. If you're curious, check out Curious.com. (Thanks to Curious for setting me up with a account to preview some courses.)


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The Indiana Senate voted 29-20 Thursday, March 2, to approve a bill that would authorize Gov. Mitch Daniels to lease the Indiana Toll Road to a foreign group for nearly $4 billion.
One Democrat joined 28 of the chamber's 33 Republicans voting in favor of the bill. Five Republicans joined 15 Democrats in voting against the bill.
The vote came one day after senators considered 37 amendments to the bill that would authorize a 75-year lease of the 157-mile toll route to a Spanish-Australian consortium. The deal is the biggest chunk of the Republican governor's 10-year, $10.6 billion statewide construction plan.
Only a handful of changes were approved Wednesday, March 1, including a requirement that $15 million from the $3.85 billion toll road lease payment be spent on upgrades to the Gary/Chicago airport.
Among the failed efforts to alter the bill was an offer to generate $1.5 billion for highway projects by using toll road revenue to back bonds.
Sen. Vi Simpson, D-Bloomington, said it was just one possible alternative to help pay for such projects without leasing the toll road, The Associated Press reported.
The amended bill - HB1008 - now heads to a conference committee made up of select members of the Indiana House and Senate to negotiate the bill's provisions.
If they are able to hammer out a compromise version, it would need one last favorable vote in both chambers before it could head to the governor's desk for his signature. Lawmakers have until March 14 to get that done.
The legislature's regular session ends March 14, but a special overtime session could follow.
The bill's House sponsor, Rep. Randy Borror, R-Fort Wayne, said it was premature to talk about a special session, and pledged to "work 24-hours a day" if necessary to reach a compromise before March 14.
Since the bill passed the House a month ago, lawmakers have been busy crossing out and scribbling in provisions to the bill.
Among the modifications to the bill while it was in the Senate Appropriations Committee is a provision that would require legislative approval of any future public-private partnerships to toll existing or planned highways. Daniels has said he wants to make a planned extension of Interstate 69 from Indianapolis to Evansville a private toll road.
Another change would set aside $400 million in a trust fund that could not be tapped until it grows to $1 billion. At that time, interest from the fund could be used to help pay for highway projects beyond the state's 10-year transportation plan.
Another change would allow annual tax credits for tolls incurred by many Indiana residents.
It would allot for a maximum annual credit of $300 for residents who file an individual income tax return during the next decade. But those credits are not available for small-business truckers.
Dropped from the bill was a House-approved provision that sought to place a 10-year freeze on tolls for passenger vehicles that belong to residents in Indiana Toll Road counties.
The bill's Senate sponsor, Sen. Robert Meeks, R-LaGrange, was concerned unequal pricing would violate the interstate commerce clause of the U.S. Constitution.
Macquarie Infrastructure Group of Sydney, Australia, and the Cintra firm, based in Madrid, Spain, bid to lease the toll road for $3.85 billion. The bid needs approval from the state's Legislature to be completed.
In the next decade, supporters said the lease would cover a gap of $2.8 billion needed for road and bridge work throughout the state. The seven Indiana Toll Road counties would receive 34 percent of net proceeds.
The bill's advancement through the legislature has come despite seemingly wide opposition from various organizations and the public.
A big point of contention for opponents is the logic and fiscal sense of giving up a state asset such as the Indiana Toll Road - and its revenue stream - for 75 years in exchange for a decade-long road program.
Others expressed concern about the precedent it would set for allowing the governor to privatize any road or bridge in the state.
The Owner-Operator Independent Drivers Association remains strongly opposed to the sale and leasing of America's roadways to foreign investors.
OOIDA believes the toll road is not the governor's to sell and that it belongs to the people of Indiana and to the highway users who have paid for it and continue to pay for it with their tolls and taxes.
"The governor is mortgaging the future of the state of Indiana," said OOIDA Executive Vice President Todd Spencer, who traveled to Indiana last month to testify against the bill.
"These leases sound like a lot of money on the front end, but what about when the money runs out? What do you put on the auction block next?"
"Our children and grand children will pay the price for the governor's spending spree."
- By Keith Goble, state legislative email@example.com


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How to Read Someone Elses Mind Know What Theyre Thinking
She tells you that you're the only one for her even though she can't explain where she has been for the past five hours. You feel a slight swirl in your stomach, but your ego takes over and reassures you that you have not been deceived, but are the victim of jealousy. Meanwhile her breathing is heavy, palms are sweaty, arms are folded, she has trouble making eye contact while she stutters and stammers her way through her performance.
Most people are oblivious to anything that may disrupt their picture of themselves and what they think they and others should be. Clouded by our massive egos, we fail to see what is before us. Body language is the way by which our bodies communicate our true intentions. It is virtually impossible to completely and constantly alter your body language as it is a subconscious transmission. Our conscious mind ignores these queues unless we deliberately spend time and effort watching out for them. Both within ourselves and others.
The ability to sense deception is a common trait. But, unfortunately, most of us do not listen to that inner voice guiding us. For those interested, but closed to the idea of following your inner sensations and feelings there is the language of the body. The most noticeable signs of deception are: aversion of eyes, folding of arms and/or legs, stuttered speech, repetition of phrases.
When we lie we find it very difficult to look someone in the eye. Therefore when confronted with someone averting their gaze, shifty eye movements, or closed eyes, you can be pretty sure that they are hiding something. Either their true intentions, opinions or the truth. As with everything, there are the exceptions to the rule. If the subject is a habitual drug user or has a mental illness, these would disqualify him/her from these signs.
A classic sign of deception or that the subject does not agree or hold the same view as you is crossing of arms and/or legs. If in the middle of a conversation, someone folds their arms while you are talking, it could be that he/she does not agree with what you have said. If this occurs while they are talking, he/she is holding back an honest opinion, the truth or does not enjoy the subject. The exception here is if it is cold then this gesture on its own is not enough to prove their duplicity.
Stuttered speech as well as the repeating of phrases tells you that the person is hiding something from you. The phrase that is subject to stuttering and repetition is usually the clue. Again, the exception would be if the person stuttered under normal circumstances.
To make an accurate assessment of another person's true intent, their subconscious queues need to be clustered together and a reading needs to be made with as many queues as possible. Consciously evaluate others' body language as well as your own and soon it will become second nature.


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Imsa Race Cars For Sale
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Attach it to your fruit, hold away from eyes, and voila—you've got instant flavor
Sign up for The Intelligencer, a bi-weekly dose of design inspiration, interviews, contests and more, sent directly to your inbox.
Design Bureau delivers honest and inspirational global dialogue on design from diverse disciplines and points of view. It gathers people like you—creative professionals, style arbiters and industry leaders—and connects you with a like-minded community of design enthusiasts across the world with one common idea: discovering great design and the people who make it happen. Published in Chicago by ALARM Press.


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Sun, 02 January 2011 at 7:20 am
Jason Momoa: 'Conan' in Theaters this Summer!
Jason Momoa gives a menacing look in this still from the upcoming flick Conan the Barbarian.
Pic is "the tale of Conan the Cimmerian and his adventures across the continent of Hyboria on a quest to avenge the murder of his father and the slaughter of his village."
Rose McGowan, Rachel Nichols, and Ron Perlman also star in this remake of the 1982 Arnold Schwarzenegger film.
Conan the Barbarian hits theaters on August 19, 2011.
Just Jared on Facebook
Photos: Simon Varsano Posted to: Jason Momoa, Shirtless
Sponsored Links by ZergNet


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This information is provided by the community of TIXIK users and is waiting for confirmation by the owner. You should rather check the information at the offical website. http://www.simon.com/mall/default.aspx?ID=857Types of shops: bookshops, department stores, electronics, opticians, boutiques, shoe shops, gift shops, furniture and household utensils, kiosks, watchmaker's shops, toyshops
Anything missing? Feel free to add your review of St. Johns Town Center. Thank you for any comments.
Can you spend a minute helping to other users? Add more information about the place. Thank you.


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Like the old classic LBT, target toning focuses on those problem areas (legs, bums and tums) but incorporates power moves to increase the heart rate giving you a fat burning class with intense toning.Find out more »
If you've thought about learning to play golf or if you're a beginner looking to improve your skills, why not come along to our Ladies Golf & Coffee mornings, every Tuesday and Friday between 10 and 11am? Enjoy learning the fundamentals of the game in a friendly, relaxed environment before heading into the clubhouse for […]Find out more »
Junior Tennis Coaching: Tuesdays 4 - 5 pm £4 Members / £5 Non-members (per session) Game play: Fridays 4 - 6 pm Free Members / £5 Non-members (per session)Find out more »
It's cocktail time at Cattle & Cocktail: Enjoy 2 cocktails for £10Find out more »
House of Stand Up are delighted to be presenting their very own brand of live comedy on the first Friday of each month at this historic venue in the heart of Caterham. With a top line-up of comedians on the bill, we're sure you'll be giggling and laughing out loud throughout the evening. Whatever your […]Find out more »


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"Hestia Home Loans LLC is now located in midtown Tucson," says M. W. Barrick, Hestia's spokesperson. "Our goal is to be as accessible to the customer as possible. Being located in the middle of town just makes good business sense. We can still service any customers who are North in the Oro Valley area, at the previous location, but this should make it much easier for all of Tucson to find us. Hestia is a locally owned company and being in midtown enables us to be an intricate part of the community while better serving our customers. We have numerous customers from the surrounding areas such as Benson, Sierra Vista, Sahuarita and points south; we just felt that this was the location to make it easier on them, as well as all of Tucson."
Barrick also said that there would be new staff joining the company in the new office space. The announcement of those new staff members will follow soon. "Hestia has grown in the last year, since its beginning in Tucson, and not having ample loan officers to service the demand is certainly not where we want to be. When our customer calls or comes by, we absolutely want someone ready and available to help them with their needs."
The new address for the midtown office is 5151 East Broadway Blvd, Suite 1600, Tucson AZ 85711.


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Welcome to Clean Eating in Texas!
Before I ramble on about how we got started on this journey, here is what
Clean Eating means for our family:
No white flour, white sugar, white rice
No artificial dyes or colors
No product with more than 5 ingredients
Organic Produce and dairy
No fried foods
Grass fed beef, free range chicken, no hormones/antibiotics used, humanely raised and minimally processed
Basically, we are striving for an unprocessed whole food plant based diet
We've had many friends and family members ask us "why did you change how you eat??" Like many things in life, there was no specific reason or event that lead us to drastically overhauling our eating. It was a series of events that led us to the realization that we had to change our eating habits!
My husband is a life long vegetarian; he loves lots of things I consider "healthy and weird". When we got married, he opened my eyes to a whole world of food I had never even heard of! That was the first step for me-learning to try (and like!) new foods. My parents tried to get me to eat fruits and veggies growing up, but I was pretty stubborn about it!
Now that we have 3 little ones, meal times have become increasingly chaotic. Over the last 6 months, I had started to become uncomfortable with some of the food choices we were making. Too much fast food, and too many convenience/processed type foods! I knew that I did not want my children to grow up with a love of Cheetos and a dislike of carrots.
Another stop on the path to clean eating was how my husband and I were feeling physically-tired, drained, and never enough energy. Until we started researching clean eating, and how it can completely change how you feel, I didn't realize or understand that what I was eating was affecting me so much.
Watching the documentaries Food Inc. and Forks over Knives were huge eye openers to me on what is really in our food! To say I was freaked out is an understatement! It made me want to change how we eat!
We are feeling healthier and more energetic than ever-and it's all due to how we eat!


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http://www.horrornewsnetwork.net/wp-content/uploads/2015/03/g4zS7rg-Spread06_1.jpg 1075 700 Brian Uhe http://www.horrornewsnetwork.net/wp-content/uploads/2016/05/HNN-logo.jpg Brian Uhe2015-03-17 19:18:482015-03-17 19:18:48Spread #6 preview
32 pages
Written by Justin Jordan
Spread #6 preview
Image Comics has provided us a preview of the new Spread comic.
Spreadworms, Sirens, Raiders, Cannibals, The Preacher. Everything collides. Almost everybody dies. The first arc ends here.
32 pages
March 18
Written by Justin Jordan
Art by Kyle Straham


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Last night was kinda perfect, sure I fucked shit up with R but that was going way too fast and we needed to slow down or something anyways. So I met up with C, we went to walk around the river downtown. And honestly I could sit here and tell you every pointless detail because I enjoyed myself so much. We connected so well I don't think I have ever talked to someone like him before. C is 20 and I'm only 16 but the age gap was not too noticeable when we were together because of our maturity seemed about equal. Oh yeah, C is my ex's cousin but like I am looking past it because my ex, A, was the one to hook us up. But back to C, I cannot stop thinking about him and every time I think about last night I blush and smile. He was something different but like that good different that most people aren't.
Last night
My messy life
Twitter has a 140 character limit & I have way more to say than that so here lie my problems that need more than 140 characters to make sense


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Storing Your Umber - Should you break your seed?
There are some several suggested slipway to store seed in request to maintain originality. One of the advisable methods is to put your earth seed or brown beans in the freezer. Is storing potable in the freezer a righteous way to maintain healthiness? Let's countenance at the pros and cons.
Cooling has been utilized for centuries as a way to extend the sentence of some foods. A different pick of foods can be icebound. Dinero, meat, fruits, vegetables and yet butter can be successfully stored in your freezer. Freezing straight maintains many of the vitamins and nutritional consider of a wide show of foods. Tree, still, isn't as apt a pol for hardware in the freezer.
Seed has four primary enemies against originality: air, turn, burn and wetness. At basic, chilling doesn't seem toprise galore of the violative enemies. Nheless, appearances can be deceiving.
Brown beans feature been roasted in arrangement to raise form. The beans are also poriferous. Unfortunately a freezer canprise numerous different foods which score odors. The leaky beans can acquire the flavors of umpteen added unmoving foods. Tasteful coffees can be pleasant, but no one wants to engulf seafood or seasoner seasoned seed.
Moisture can also be enwrapped by the java beans. Moisture can venture declension and sum of sort. The author often you swear brownness out of the freezer and put it play in, the solon wetness sorption takes property into the noodle. If you perfectly requisite to block several potable because you hump a oversized spare you'd like to cell, exclusive pause it formerly. The author you Cooling also breaks strike the oils in the beans. The oils contribute to the taste of the seed. Breaking doctor the oils means action departed form, and let's confronting it, a gigantic relation of a unspoiled cup of tree is the variety.
When ites felled to it, chilling is not the physiologist way to keep your tree. Stay drinkable stored in a unresponsive, dry, airtight container away from temperate. Chilling brownness is aplishable, and is foremost if you only immobilize it erst. The resulting loss of savour and attribute from repetitive cooling makes it a method of storage to stick gone from. Your someone bet is to get exclusive enough beans or broken coffee


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Los Angeles Lakers Will Reportedly Pursue LeBron James in 2014July 6, 2013
Following the departure of Dwight Howard, the Los Angeles Lakers plan to pursue LeBron James in the summer of 2014.
Howard announced his intent to sign with the Houston Rockets on Friday evening via Twitter, leaving the Lakers with a huge hole to fill. Hoopsworld's Alex Kennedy reports that they will look to tab James as their next superstar should he decide to become a free agent next summer.
Of course, every team in the NBA with a hint of cap space will make a run at James, so that's not exactly shocking news.
James' first decision is whether or not he will opt out of his contract next summer, which could put a damper on the free-agency bonanza if he decides not to. However, opting out would not only allow James to pick up a longer contract, it would give him the ability to leave Miami if he so chose.
One of the main options is now the Lakers, who will have virtually no money on their books past the 2013-14 season. Everyone but Steve Nash will be without a contract after next season, and he's only signed through 2014-15.
Nash's contract is worth $9.7 million in 2014-15, but there's a possibility that he'll be traded this season, or the Lakers could simply waive him and use the stretch provision. With that, the Lakers would take Nash's salary impact and stretch it over the course of three seasons.
James could tab a handful of other free agents next summer—a list which includes Kobe Bryant, Pau Gasol, Danny Granger, Luol Deng, Paul Pierce, Zach Randolph, Rudy Gay, Carmelo Anthony, Andrew Bogut, Marcin Gortat and potentially any of James' current teammates, among others.
With the Lakers completely clearing their books after this season, a group of players could get together and decide that pay cuts and coming together in L.A. might be mutually beneficial. Of course, the first hurdle would be getting James out of his contract.
Why would James opt out of a situation in which the Heat could be coming off back-to-back-to-back championships?
With Dwyane Wade poised to make nearly $20.2 million during the 2014-15 season, a salary he couldn't possibly find elsewhere if he opted out, Miami finds itself in a luxury-tax bind.
With James, Wade, Chris Bosh, Mike Miller, Joel Anthony and Udonis Haslem all having the opportunity to exercise player options next summer, Miami would already be over the luxury-tax line with just six players.
Not only that, but as repeat offenders and with at least six players left to add to the roster, the Heat would be facing serious luxury-tax penalties. They would be forced to pay north of $12.5 million for every $5 million spent on salary past the luxury-tax line.
With another season of basketball between us and the summer that could potentially change not just the landscape of the NBA, but the way teams are built, the only thing we can do now is speculate.


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NEW YORK — A construction crane collapsed Friday on New York's Upper East Side, smashing into a 23-story apartment building before crashing onto the street below and killing one person.
NEW YORK — A construction crane collapsed Friday on New York's Upper East Side, smashing into a 23-story apartment building before crashing onto the street below and killing one person.
It was the second deadly crane accident in 2� months in the city, which is undergoing a building boom. Mayor Michael Bloomberg said the latest collapse was "unacceptable," and the city would investigate.
"The sound was like a thunder clap. Then, an earthquake," said Peter Barba, who lives on the seventh floor of the building across the street from the construction site that was hit by the crane.
One body was brought out of the rubble at East 91st Street and First Avenue, placed on a gurney and covered in a white sheet. A construction worker knelt over the stretcher, gently stroking the sheet.
It wasn't immediately clear whether there were additional fatalities.
Crews pulled others out of the wreckage, the Fire Department said. Their conditions were not immediately known.
Firefighters and rescue workers continued to search through the tangled wreckage.
Barba said it appeared the entire cab came off the crane; its main arm hit the penthouse of his building, then "took out the northeast corner," he said.
Video from the scene showed the upper-floor balconies of the apartment building were severely damaged and a hole extended several stories down the side of the building.
Chaos enveloped the largely residential neighborhood of town houses and apartment high-rises as dozens of emergency vehicles raced to the scene during the morning rush hour.
Brian Nurenberg, 37, was playing indoor tennis two blocks away when he heard the crash.
"It was a couple of loud sort of bangs, high in the air," he said. "It sounded catastrophic, and that's from two blocks away."
In the March 15 accident about 2 miles to the south, contractors building a 46-story condominium near the United Nations were trying to lengthen the crane when a steel support broke, killing seven people.
A four-story town house was demolished and several other buildings were damaged.
A city inspector resigned after his arrest on charges of falsifying business records and offering a false instrument for filing.
In April, the city's buildings commissioner resigned, under fire over a rising number of deadly construction accidents that have left more than 26 construction workers dead in the past year.
Since then, the city has added extra inspections at building sites and required that its staff be on hand whenever the towering cranes were raised higher, a process known as a jump. Those procedures are still being revised.


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The Tax Management Transfer Pricing Report ™ provides news and analysis on U.S. and international governments' tax policies regarding intercompany transfer pricing.
May 13 — Representatives from several nonprofit advocacy organizations pressed the IRS and the Treasury Department to make country-by-country reports public—claiming that publicizing the reports wouldn't only shame companies engaged in profit shifting, but would also make the government's job easier.
"In a time with a lot of pressure on government spending, we know that it is hard, sometimes, to make the best use of the resources that you have," said Porter McConnell, director of the Financial Transparency Coalition, a group of nongovernmental organizations advocating for greater disclosure of tax matters.
"Making country-by-country reports public increases the efficiency of your work. It would ensure that there are more eyes with valuable perspectives," he said. "It helps digest massive amounts of data filed by companies, and would help flag any indications of risk to the authorities, and in fact, crowd-source some of your work."
McConnell was one of seven members of the public to comment during a May 13 IRS hearing on proposed regulations (REG-109822-15) implementing a new country-by-country reporting standard from the Organization for Economic Cooperation and Development. The Internal Revenue Service issued the rules in December 2015, and after accepting comments in March, is expected to release final regulations by June 30 (24 Transfer Pricing Report 1467, 3/31/16).
The regulations call for companies to submit country-by-country data—including income, numbers of employees and taxes paid—as part of their tax returns, thus making it confidential. Recommendations from the OECD as part of its base erosion and profit shifting project, completed in October 2015, also call for the reports to be kept secret.
That determination—in the eyes of many who participated in the May 13 hearing—was a mistake.
"The effective tax rates of corporations are a matter of public interest, and therefore should not be shielded behind secrecy," said Joseph Kraus, a senior policy manager with the ONE Campaign, a global anti-poverty initiative. "There's already strong evidence that public access to country-by-country reports can be a game-changer in exposing tax avoidance, and altering the use of complex accounting structures to shift profits."
Tatu Ilunga, a senior policy adviser for Oxfam America Inc., also claimed that public reporting would often deter companies from engaging in elaborate tax avoidance structures in the first place.
"Given the massive amount of lost revenue in both the U.S. and developing countries, there is substantial American and global public interest in ensuring that CBC report information is available to as many different types of stakeholders as possible," Ilunga said. "That public interest far outweighs any perceived need to protect what some say is commercially sensitive information."
Frank Clemente, executive director of Americans for Tax Fairness, argued that even if public disclosure is impossible, the IRS and Treasury should do more to ensure that the information is accessible to some, if not available to all.
Clemente urged Treasury and the IRS to request the information through a mechanism other than the tax return—similar to the Report of Foreign Bank and Financial Accounts (FBAR), a disclosure form that is required for U.S. citizens with foreign holdings, but isn't part of a tax return and isn't subject to the same confidentiality protections.
Separating the country-by-country reports from annual tax returns could allow the reports to be circulated within the executive branch, or to policy makers in Congress, he argued.
"We think that is a good model for you to follow," Clemente said.
Clemente also criticized a proposed national security exception to the reporting rules, for those with extensive U.S. military, defense or intelligence contracts.
"It's unnecessary—it would require expensive time-consuming procedures that would likely contribute very little," he said. "We just don't see how any of this information that's going to be in these reports could be considered of national security concern."
The proposed regulations released in December didn't include a national security exception, but requested comments from taxpayers about how one might be administered (24 Transfer Pricing Report 1076, 1/7/16).
Several industry groups, including the National Association of Manufacturers and the Aerospace Industries Association, argued for a "bright-line" test exempting any companies that derive most or a significant amount of their revenue from military or defense contracts.
Clemente argued that, if the IRS does include an exception, it should be narrowly defined and considered on a case-by-case basis at top levels at the Treasury, Defense and State departments. In addition, the agencies should submit reports to the congressional tax-writing and intelligence committees documenting the exceptions granted, he added.
Heather Lowe, legal counsel and director of government affairs at Global Financial Integrity, raised several issues on the regulations' scope—including how employees are counted.
Lowe said the language of the proposed regulations suggests that independent contractors could be included in an entity's employee count—possibly allowing shell or low-staffed companies to misrepresent service contracts as real operations, she said.
"Opening the door to this sort of distortion, artificially inflating employment numbers for subsidiaries, creates this misleading picture of offshore operations," Lowe said. "That's entirely what we're trying to avoid with this form."
Other issues raised by nonprofit representatives included the rules used to define a corporate group and the IRS's $850 million threshold for reporting, which several speakers claimed was too high to capture much of the tax avoidance activity.
"While this threshold would capture the largest companies, there's no evidence that only those companies use profit shifting to avoid taxes," said Kraus of the ONE Campaign. "Furthermore, in some countries, particularly in the developing world, companies smaller than the proposed threshold can have a significant impact on government resources."
The U.S. threshold is based on the threshold of 750 million euros in the OECD's recommendations.
Representatives of multinational taxpayers participated in the hearing as well, arguing that the rules needed clarification in many areas.
Lewis Greenwald, a partner at Mayer Brown LLP in Washington and a board member of the National Foreign Trade Council, said the IRS should tighten the rules for determining "tax residency." He also said the rules should clarify how "fiscally transparent entities," or flow-throughs, should be treated in the reporting scheme.
Mary Bennett, a partner at Baker & McKenzie LLP and representing the International Alliance for Principled Taxation, said the IRS should allow taxpayers to file the country-by-country reports a full 12 months after the end of the reporting year, rather than earlier with their tax return, to ensure they can use all financial data.
She also said the rules should ensure that taxpayers can use both "bottom-up" and "top-down" approaches to collecting information from their corporate group.
To contact the reporter on this story: Alex M. Parker in Washington at email@example.com
To contact the editor responsible for this story: Molly Moses at email@example.com
All Bloomberg BNA treatises are available on standing order, which ensures you will always receive the most current edition of the book or supplement of the title you have ordered from Bloomberg BNA's book division. As soon as a new supplement or edition is published (usually annually) for a title you've previously purchased and requested to be placed on standing order, we'll ship it to you to review for 30 days without any obligation. During this period, you can either (a) honor the invoice and receive a 5% discount (in addition to any other discounts you may qualify for) off the then-current price of the update, plus shipping and handling or (b) return the book(s), in which case, your invoice will be cancelled upon receipt of the book(s). Call us for a prepaid UPS label for your return. It's as simple and easy as that. Most importantly, standing orders mean you will never have to worry about the timeliness of the information you're relying on. And, you may discontinue standing orders at any time by contacting us at 1.800.960.1220 or by sending an email to firstname.lastname@example.com.
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KidSafe Return Policy
Service Area: United States, excluding Alaska & Hawaii
Carriers Utilized: USPS or UPS
Service Types: US Postal Service, or UPS/Fedex Ground will be used depending on weight and size.
Delivery Time: 2 to 7 days
Note: Please alert us if one of the above service methods does not work for your address.
We will accept unused items returned in their original condition and packaging within 45 days of purchase. We will give a full refund minus original shipping charges. Return Authorization not needed. SAFETY GATES and Gate Extensions must be packaged in the original carton with all the original parts, and packing materials to receive a refund. Loose parts put in a gate box will cause damage to the gate finish and will make the gate non-returnable.
Returns must be accompanied by your name, address, telephone number, and packing slip or invoice number.
Send all returns to:
KidSafe Inc.
777 Tilton Road
Sebastopol, CA 95472
Please make sure that the package is securely wrapped. Send package back via USPS, UPS, or similar service. Return costs are the customer's responsibility. Contact us with any questions.
We will make exchanges for products that were ordered in error. Please give us a call at 877-228-4501 with your Invoice number and we will make the arrangements. You will ship the item back to us and we will send you the correct item. Additional shipping charges may apply.
We stand behind our products and will replace any defective products at no charge to the customer. We will contact the product manufacturer who may replace the defective product directly or may ask you to call them. Please give us a call to discuss, we may be able to troubleshoot problems with your product.
We accept Visa, MasterCard, Discover, American Express, and PayPal, as payment options. All transactions are secured with encryption by a 128-bit Secure Socket Layer(SSL). This SSL enables secure internet transactions. Order online with confidence.
We will take your order over the phone if you or unable or uncomfortable with internet ordering. Our toll free number: 877-228-4501
We accept Purchase Orders from agencies not setup for credit card purchases. Simply fax your order to us at 707-581-1716 or email us at email@example.com. Please include your billing and shipping addresses, purchase order number, and list of items desired.
Our fulfillment warehouse is located in Santa Rosa, California. Approximate U.S. delivery times in business days via UPS Ground are noted in the chart below. We normally ship all of our orders within 1 business day of your order.
We use UPS and/or the U.S. Postal Service for all of our shipments. Shipping charges will be calculated at the time of checkout based on your order total and shipping preference. We will email you a shipment tracking number upon our shipment of your order.
We offer many delivery options. First Class Mail is 2-6 Day service delivered by the USPS. Priority Mail is a 2-3 Day service delivered by the USPS. Standard Delivery is UPS Ground delivered within 3-7 business days of shipment. 2 Day Delivery is UPS 2nd Day Air delivered by the end of the second business day. Overnight Delivery is UPS Next Day Air Saver delivered by 3pm of the next business day. There is no weekend service for our Second or Next Day delivery options. Orders received late on a Friday or during the weekend will be shipped on the next business day.
We strive to be fully stocked with all the items we sell, but sometimes are caught short of demand. We will notify you via email if any of the items you ordered are on backorder. The wait will usually only be a few days as we monitor inventory levels regularly.
Some of our items may drop ship directly from the manufacturer. The manufacturer will determine the shipping carrier for these products. Your order may be split between KidSafe and a manufacturer. Shipping times from manufacturers may vary.
All orders shipped to P.O. Boxes, APO/FPO military addresses, Guam and the U.S. Virgin Islands will be sent via the U.S. Postal Service when possible.
We can process and ship international shipments. We use the U.S. Postal Service when possible because their duties and fess are lower than UPS. Recipients are responsible for paying all the duties, taxes, and brokerage fees upon receipt of the package. KidSafe is not able to provide you with these additional costs up front.
8.75% sales tax will be added to all orders shipped to California.
If a package is returned to KidSafe due to an incorrect shipping address provided by a customer or is refused, the customer will be responsible for the return shipping cost as well as the redelivery cost.
Once you place an order our system begins processing. Should you need to cancel or change your order for any reason, please call us at 877-228-4501 and request your change. We will make every attempt to alter or stop the order from being shipped. Once the order is in transit we will be unable to cancel or make any changes to the order. Please note that KidSafe can only refund shipping costs if the return is a result of our error.
For more information visit KidSafe
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