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I'm a masochist. A sadomasochist, technically, but today we're not talking about my sadistic side. I recently started dating a vanilla (I know, horrors!) and a few months ago, in the "getting to know you" phase of things, he asked me about my relationship with S&M and what being a masochist is all about, for me.
I didn't realize just how hard my desires are to explain until I had to explain them to someone for whom the answer to "you know what I mean?" will never be yes. With other kinky folk, I can say, "well, you know how blah blah blah makes you feel like so and so etc?" And they say "oh yeah totally and also blah blah blah." But now I was starting from scratch, with no expectation that he would relate, or already know what I'm talking about before I put it into words.
I don't think I did that great of a job explaining it to him.
Part of the trouble with explaining what it's like being a masochist is that, for me, pain serves a lot of functions depending on what I want from the scene. Much in the way that people have sex for a lot of different reasons (for the physical pleasure, to feel loved by their partner(s), to feel forgiven after an argument, to vent frustration with each other, and on and on), I crave pain for a lot of different reasons.
It might also be useful to back up and clarify the definition of "pain." My very favorite sex educator, Midori, doesn't talk about pain when she talks about S&M. She refers to "intense sensation." Her reasoning goes kind of like this: a person just finished a long scene, where s/he was bound to a cross and whipped bloody. Tears stream down his/her face, and s/he is floaty and exhausted. Then s/he steps down from the cross and stubs his/her toe. Suddenly s/he doesn't love pain so much anymore. I don't necessarily agree with her choice to nix the word pain, but I'd go with "controlled pain." The stubbed toe is uncontrolled pain. Accidental pain is generally unwanted pain. It's pretty rare that even the most thoroughgoing masochist will burn him/herself on the stove and be pleased about it.
So when I talk about pain in this post, I'm talking about controlled pain. I'm talking about getting tied up, beaten, stretched, shoved, crushed and pushed to my limits by someone who knows what s/he's doing and has my consent.
Definition covered? Good! Moving on.
When I think about being a masochist, there are two big umbrella categories of pain I think of. I call them the "fuck me" and the "fuck you." As in, when I'm in pain, I'll be screaming either "fuck me," or "fuck you."
The first kind of pain, the "fuck me" kind, is pain that I like. This kind of pain is pretty straightforward if you have a basic understanding of body chemistry and endorphins and such. When I get aroused, the lines of pain and pleasure get pretty blurry. And that's all there is to that. So that means that I enjoy things like having my hair pulled or getting bitten, or smacked, as a part of sex. It feels good, it makes me wet. The fact that it does that for me and not for everyone is, I suppose, simply a difference in body chemistry.
The second category of pain, the "fuck you" kind, is the kind I don't like. This pain makes me cuss and scream and sometimes cry in pain and rage because I hate it. But I still want it, and I still ask for it, and I'm pleased and content afterwards. Explaining this process to someone who is neither sadist nor masochist is problematic. Why do I want something that I hate? What do I get out of it?
The easiest answer would be catharsis. The misery and the rage are a release of emotion, kind of a brain dump. In the same way that some people scream and throw things and commit acts of violence against inanimate objects as a safe release for their emotions, I like to be hurt. That answer is true, but incomplete. The drained feeling when I've screamed and cried and my body is aching and throbbing is cathartic. But there's something else going on in my head as well.
When I play hard with someone, when s/he gives me the "fuck you" kind of pain, it has to be someone that I trust completely, because I'm asking this person to dig into all the nasty darkness inside me and make me feel it on the outside. I'm asking my top to make me feel misery and fear and pain and rage, and to expose all of it. I don't like to display my negative emotions in front of anyone. I consider myself pretty emotionally honest, and I'll tell a person how I'm feeling, but I don't like to show it. I don't like to cry where people can see, and if I show anger I will be comically hyperbolic so it's made non-threatening. I am pretty emotionally fragile, and because of that my emotions scare me; I constantly worry that exposing my emotions to other people will scare them too. Thus will I be pegged as "that crazy girl," and henceforth be unlikeable. Is this a rational fear? Probably not. But it's one I suffer from constantly, and more so within a romantic relationship, because it comes with not only a higher expectation of emotional honesty, but higher stakes if I scare the person off.
However, if the reason I'm sobbing and screaming and crying is because I spent the last 30 minutes getting caned, no one could blame me for that. I can be as vulnerable and messy as I need to be, and trust that the person I'm with expects it, and knows how to handle it. And even better, I know that my partner won't feel the guilt that often comes with seeing someone they love in pain. If the reason I'm crying is because I'm anxious, my partner feels the need to take some kind of responsibility, that they should be making me happier. And once my partner starts to be upset, I shut my own flow of feelings off and take care of them. During a scene, my partner is making my cry on purpose, because I asked for it. My extreme emotional reaction is not going to cause guilt or worry, because it was intentional and controlled.
At this point, I realize it's starting to look like I use pain as therapy. I don't know if it makes it any better to point out that I'm also in therapy, but I will also say that therapy helps me in a very different way. When I see my therapist, I speak candidly about my emotions, including the hurtful and irrational ones, and the parts of my life that are affecting them. Together, we develop strategies to more effectively deal with the parts of my life that cause anxiety and pain.
When I go into a scene where I want the "fuck you" pain, I'm not trying to fix anything. I'm not trying to resolve my anxiety, I'm just giving myself permission to display all the darkness and the madness that fly around my head all day. I can give up all semblance of the emotional control, and even sanity, that define my daily existence. Afterward, if it's a good scene, the otherwise constant noise in my head is muffled for a little while. I'm exhausted, drained, and quiet. And my partner is there with me, to hold me until I come back to being myself. I've exposed everything about my mind that frightens me, and my partner has caused it, seen it, and is ready to keep loving me afterward. In much the same way that having sex with my partner reaffirms that they love me and find me attractive, being hurt by a partner reaffirms that I can trust them, and that they're not afraid of my darkness.
Every time I've read and revised this post, it still aches of incompletion. I don't think there are words for the kind of satisfaction that comes from being broken by someone I love. I don't know that I can really properly explain how it makes me feel, and why I crave it. I do hope that I've at least chipped away at a little of the mystery.


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Leftover Tacos
What do you do with leftover pulled pork (or chicken, or beef, or whatever large chunk of meat that you recently smoked or grilled)? Make Leftover Tacos. This is an easy meal that is sure to please, even if it isn't very authentic.
- About 2 cups of whatever meat you have leftover, chopped or shredded into small pieces
- 1 medium onion, chopped small
- 1 bell pepper, any color, chopped small
- 1 tbs. olive oil
- 2 tbs. white wine
- 1 tbs. taco seasoning (substitute chili powder, garlic powder, cayenne pepper, and ground cumin if you aren't feeling lazy; mix them up in proportions that make you happy)
- 2 tsp. Chipotle-flavored Tabasco Sauce
- Chopped fresh cilantro
- Shredded lettuce (optional)
- Shredded cheddar cheese (optional)
- Chopped tomato (optional)
- Salsa or hot sauce to taste
- 8-12 corn tortillas (depending on how many of the optional ingredients you use)
I'm going to pretend you aren't sitting there thinking "how can this be easy with all those ingredients" and proceed as if nothing is amiss. Because it isn't. Start by heating a large skillet on the stove and add the olive oil. Stir in the onions and peppers and saute until limp (or go ahead and caramelize them if you really want to). Add the chopped/shredded meat, pour on the wine and chipotle sauce, and add all the spices. Stir well and reduce heat to a low simmer.
Heat about 1/2 cup of oil in a small frying pan, preferably one that is only slightly bigger than the diameter of the tortillas. We prefer to use olive oil for this process as the tortilla shells don't seem to absorb as much oil. The oil is hot enough when bubbles form around a small piece of tortilla is dropped in the oil. Fry each tortilla, turning once after about 15-20 seconds, and folding into a taco shape immediately after turning. Use a long set of tongs for this, and hold one side of the fold out of the oil while the other is cooking. Once the one side is done to your satisfaction, flip the tortilla over and hold the cooked side out of the oil. When done, remove from the oil, drain well, and set on a paper towel to absorb any extra oil. Repeat as necessary until you have enough taco shells for the meal.
Assemble the tacos by spooning the meat into the taco shells. Add some chopped fresh cilantro and the optional ingredients as desired. Top with your favorite salsa or taco sauce, and go eat. No beans required…

subset: commoncrawl


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Be careful what you wish for... I didn't quite believe in it until I met you. You were a dream come true, only fear being, could it indeed be a dream that would leave me shattered, once it is over.You showed me things that I didn't know existed, you showed me fractions of myself, that would have remained hidden forever. You surrounded me, engulfed me,completely shut me off from the external world.You touched me, No protests, no resistance, absolute surrender. You knew it would happen. didn't you??I was lost, in the truest sense of the word. Yet when you left I felt nothing, possibly because I anticipated it.
Time spent with you would remain a frozen account in my memory bank.


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Published Jan. 11, 2018
KINGSPORT, Tenn. – The Kingsport City Schools Board of Education will hold a special called meeting on Monday, January 22, 2018 at 6 p.m. in the Tennessee Room at the KCS Administrative Support Center, 400 Clinchfield Street, third floor, downtown Kingsport. All Board meetings are open to the public.
The purpose of this special called business meeting is to consider approval of an employment contract with Dr. Jeff Moorhouse to serve as KCS Superintendent of Schools. Additionally, the Board Work Session originally scheduled for Tuesday, January 23, 2018 has been rescheduled and will take place immediately following the called meeting on January 22, 2018.
Kingsport City Schools (KCS) is a public school district located in Kingsport, Tenn., serving students in Sullivan and Hawkins county. The district is comprised of 13 schools, including a Pre-K, eight elementary schools, two middle schools, one high school, a high school program of choice and an alternative learning program; with total enrollment over 7,700 students. The vision of Kingsport City Schools is to be, Student Focused … World Class.
KCS has been named the top school district in Tennessee as winner of the 2014 SCORE Prize District Award by the State Collaborative on Reforming Education (SCORE) and has earned the 2014 Achievement Award in the annual Excellence in Tennessee Recognition Program by theTennessee Center for Performance Excellence (TNCPE).
For more information on KCS, visit k12k.com, listen live on WCSK 90.3 FM, The Voice of KCS, read our blog, We Are KCS, download our mobile app for Apple / Android devices or call (423) 378.2100. We're social too; follow us on Facebook (Kingsport City Schools), Twitter (@KCS_District), LinkedIn (Kingsport City Schools) and check out our YouTube Channel (KPTSchools).


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We feel it is absolutely crucial that our employees have zero obstacles slowing them down when it comes to professional development.
We believe that genuine employee happiness is the key to success.
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Dec. 22, 2017
Final 2017 AFCA Division III Poll | Final 2017 D3football.com Poll
BALTIMORE, MD – The Johns Hopkins football team officially closed the 2017 season where it began, ranked in the top 20 by both the American Football Coaches Association (AFCA) and D3football.com as the Blue Jays check in at number 20 in each of those organization's final polls of the season.
This is the seventh consecutive year the Blue Jays have been ranked in the top 20 by the AFCA at the end of the season. Johns Hopkins has been ranked in the top 25 by the AFCA for 70 consecutive weeks dating back to the first poll of the 2011 season and Hopkins is one of just four teams in the nation to be ranked in the top 25 every week since the start of the 2012 season (Mount Union, Mary Hardin-Baylor and Linfield are the others).
The number 20 ranking in the final D3football.com Poll extends the Blue Jays' streak of season-ending top 20 rankings in that poll to five and season-ending top 25 rankings to seven. Dating back to September 26, 2011, there have been a total of 87 D3football.com weekly polls and the Blue Jays have appeared in the top 25 in 83 of those 87, including 74 of the last 75.
Johns Hopkins posted a 9-2 record, claimed a share of the Centennial Conference title for the ninth consecutive season and advanced to the NCAA Playoffs for the seventh straight year and the eighth time in nine years in 2017. Hopkins is one of just five teams in the nation that has qualified for the NCAA Playoffs every year since 2011 (Mount Union, Mary Hardin-Baylor, Linfield and Wesley are the others).
- 30 -


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|Project by Don Kriner
|posted 11-08-2014 04:25 PM
|3061 views
|11 times favorited
|8 comments
Made this for myself. I placed this at the foot of the bed as it looks like a blanket chest. My wife thought a blanket chest would have been better, but I won this one! The gun chest is made of oak and oak plywood, finished with a light amber. I had to try the guns in it to find out if I needed a counter weight at the opposite end. I did!
-- Don Kriner
8 comments so far
#1 posted 11-08-2014 07:54 PM
That's cool! How much counter weight did it take?
-- Derrick, Florida, DP Woodwerks
#2 posted 11-08-2014 10:10 PM
I fastened a 25 pound barbell to the opposite end.
-- Don Kriner
#3 posted 11-09-2014 06:41 AM
Nice job. Why the drawer instead of a simpler chest design?
-- Bob in WW ~ "some old things are lovely, warm still with life ... of the forgotten men who made them." - D.H. Lawrence
#4 posted 11-09-2014 09:24 AM
You did a nice job with the woodworking but not so good with dealing with wives. You should have made it a foot or so taller with a hinged lid. Your guns go in the drawer part and the blankets go in the top part. Happy wife happy life. :)
-- Alaskan's for Global warming!
#5 posted 11-09-2014 12:41 PM
Out of sight (or in plain sight) and out of mind. I like concealed compartments a lot.
Add a little hidden catch to the bottom and you'll have add'l security
Nice job!
-- I yam what I yam and that's all what I yam
#6 posted 11-09-2014 02:24 PM
-- Don Kriner
#7 posted 11-09-2014 02:27 PM
I thought it might double as maybe a coffee table at some point, that's why the drawer. A hinged lid would have been a lot easier to build, that is for sure.
-- Don Kriner
#8 posted 11-09-2014 04:04 PM
-- Don Kriner
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I've been kind of sleeping on Andreya Triana for a hot minute. Again my bad. The UK soulstress has been making waves for a few weeks amount the influencer set, and I see why. Her creative take of soul music has also caught the ear of venerable UK label Ninja Tune, which signed her to a deal, releasing her full length album, Lost Where I Belong in August.
The two singles, "A Place Called Obsolete," and "Lost Here I Belong," are rather amazing at best, but it's that Flying Lotus remix of Lost (which you can download for free) which is going to be that fire.
Via Maroon Cafe
A Town Called Obsolete
Lost Where I Belong
Andreya Triana – Lost Where I Belong (Flying Lotus Preview Edit)


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The National Pork Producers Council (NPPC) characterizes a Congressional amendment to end the pork checkoff as a political intrusion.
Rep. Marcy Kaptur (D-OH) offered an amendment in a House Agricultural Appropriations Committee meeting.
It states: "None of the funds appropriated or otherwise made available by the Pork Act may be used to maintain, modify or implement any assessment against agricultural producers as part of a commodity promotion, research and consumer information order, known as a checkoff program, that has not been approved by the affected producers in accordance with the statutory requirements applicable to the order."
According to NPPC, the checkoff program was approved by producers and is being operated in accordance with all statutory requirements.
The Kaptur amendment is part of the proposed 2002 House agricultural appropriations bill.
"For Congress to intervene in legislation pending before a federal court would be unfortunate," observes Barb Determan, NPPC president and a producer from Early, IA. "The settlement agreement between USDA and NPPC is currently before the courts, and there should be a final decision later this year."
The settlement agreement was reached Feb. 28. It set aside the Jan. 11 announcement by the secretary of agriculture that the pork checkoff would end.
More information on the settlement and checkoff-related activities can be found at www.nppc.org and www.porkboard.org.


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One can try to make one's trip along the Singapore River interesting simply by exploring the history behind the many bridges that one finds as one walked along the river.
I suppose for the same reason, that was why one of my friends had mentioned that it is interesting to walk along River Thames (London) and understand the background behind each and every bridge that lies along the river. I vaguely remember that some of the bridges along River Thames were considered obsolete and were removed for good.
Talking about replacing the obsolete, I understand that Anderson Bridge was built (completed in 1910) because the nearby Cavenagh Bridge was not able to cope with the increasing traffic.
The one thing that we should be grateful of is that Cavenagh Bridge was not demolished after Anderson Bridge was completed. Instead, it was converted to a pedestrain bridge, and has continued to serve this function till today. It is nice to catch glimpses of bumboats passing by while standing on Cavenagh Bridge.
References and worthy links:
- http://www.rivercruise.com.sg/bridge_pg1.htm
- http://asiatours.com.sg/hotel/singapore/fullerton.htm
- http://www1.moe.edu.sg/learn@/singaporerivertrail/sec/G041_Dunman_Sec/bridges.htm


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A lot. Like a freaky amount. My fave distance is 7 miles. Years ago I did the Susan Komen 3 Day - which is a 60 mile walk - 20 miles a day for three days. It was awesome. I trained my arse off for it - if you think you can show up to something like that without training, you are nuts. The long distance runners - including a Marine who went down hard on day 2 - thought running prepared them for a 60 mile walk - it didn't, and most of them dropped out. You have to have your muscles do that specific task for a long, long time to train.
What I found when I was working up to my final training walks - between 13 and 17 miles - is that after a certain number of miles, the walk is effortless. I think the same is true of running - you hit a point where you're all warmed up, your endorphins are working, and it's just you and your headphones and the sunshine.
Now what I really like is to walk in the woods. I don't mind street walking (not streetwalking, street walking, you naughty people!) but I really like the woods and trails. I love seeing the bunnies and hearing the birds over my audiobook, and just that silence and filtered light through the trees. Especially the filtered light.
On one of my favorite routes, there's an even one mile loop I can do - I usually do it two or three times, as the getting there and back is already four miles.
But after doing this for a while, I started to notice that I was the ONLY person that did this loop clockwise. Everyone else did it counterclockwise.
I didn't understand this. I asked people - if you were walking a track, how would you walk? They all said counterclockwise. They're defective, clearly. But I didn't get it - is my brain wired backwards? (Hold your comments please.)
But today - a SERIOUSLY glorious day - perfect Texas December day - about 70 this morning and sunny - I realized why I'm the square peg in the round hole.
I was holding my hand up to shield my eyes so I could see the dog hurtling towards me - it's a greyhound that is one of my fave walk dogs I see a lot - and it hit me. Not the dog - the answer.
I'm the only one who walks into the sun. Everyone else has their back to it in the morning. I bet in the evening, people walk the other way. On this loop only par of the walk is in full sunlight, and it's really, really bright for that part, so it makes complete sense.
Mystery solved.
There is NOTHING I love more than walking directly at the sun. I guess I don't understand why other people don't like it. It just makes me happy.
Anyway - that's my random thought for the day.
Today I'm filling in for Audrie as the host of the Inspiration challenge. I love this challenge, because she picks such interesting inspiration sites - I felt a lot of pressure to find something as cool as she does!
I had seen a shop on Etsy before Christmas that I just loved, and I chose that site because of the beautiful atmospheric watercolor prints. It's called The Wildlands, and it's gorgeous. Take a look around and then come play along. Keyword/hashtag is IC526.
For my samples, I used Frog tape for a negative and positive mask with the Leaflets Framelits, and Koi Watercolor.
For the second one, I did the reverse with the other piece of tape left from cutting the first mask. Again - I'm in awe of the crispness and performance of the Frog Tape.
I cannot BELIEVE I have never made this before - I have so many regrets right now.
Stop everything you're doing and make Alton Brown's Onion Dip. STOP. Do it.
- 3 tablespoons butter
- 1 pound 1015 onions, diced (This is 1 onion if you use a 1015)
- 1/2 teaspoon kosher salt
- 1 1/2 cups sour cream
- 3/4 cup mayonnaise
- 1/4 teaspoon garlic powder (I omitted this)
- Place the butter and onions in a saute pan over medium heat.
- Cook, stirring occasionally, until the onions are golden brown and carmelized - I cook mine for a LONG time on a 3 on my gas stove - I like them super carmelized and dark. Remove from the heat and set aside to cool for 15 minutes.
- Place the remaining ingredients in a medium mixing bowl, add the cooled onions and stir to combine.
- Refrigerate for at least 1 hour and stir again before serving.
- This dip is even better when made a day ahead. Just make sure that you cover it well with plastic wrap because fats (like sour cream) take in flavors and aromas hanging around the refrigerator like crazy old grandmas collect leftover gift wrapping.
I weep for the cartons of dip I've bought in my life and am fully repentant. Join me and repent.
Speaking of weeping over store-bought food, while I was searching for holiday recipes on my staycation I came across an AMAZING site - it's called the Family Cookbook Project. I had found a fantastic recipe there through a random Google rabbit hole for Nuts & Bolts - something my sweet friend Kim brings me every year at the holidays - and then I saw that one of the services they offer is to make your own custom family cookbook. I always think I'm going to do this myself and then I never do. It's so much work. I'm thinking of making one for all the recipes on my blog. For those of you who are weekend Iron Chefs - check it out.Our favorite cookbooks are the church lady and family cookbooks we have - it's rare that we refer to a professional cookbook for our faves.


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Special forces get wet 'n wild
If being a highly-trained Special Operations Forces (SOF) operator wasn't cool enough, up to 20 personnel from Naval Special Warfare (NSW) Command are to be let loose on powerful jet skis in the San Diego Bay.
On 7 July the NSW Command announced it was searching for a vendor to provide up to 20 of its Basic Training Command staff a five day jet ski course near its San Diego Bay base.
Incorporating jet ski capabilities into the SOF repertoire is understandable as their high speeds, acceleration and manoeuvrability make the jet ski a viable platform for amphibious operations or operations at sea.
According to the request, the NSW staff will undergo training tailored towards the capabilities of the powerful Kawasaki Ultra 300X Jet Ski, which boasts 1,498cc, 300 horsepower and speeds of up to 100kmh.
The five day programme includes initial training by day within the bay with later progression to open water ocean training at night.
Also covered will be various day and night rescue procedures and safety procedures regarding near shore hazards and 'non organic seafaring traffic'.
There are significant limitations to the use of jet skis by SOF such as their inability to cope with high waves, wind and swell. A further issue that could hinder their regular deployment could be the noise level produced by powerful engines.
Other forces known to utilise jet skis include the Greek Special Forces who have incorporated the platform into their SOF capabilities for the planning and execution of amphibious special operations since 2011. According to the Greek Army, teams on jet skis have the ability to rapidly disperse to different areas and later re-assemble using GPS.
So, as NSW trainees tear it up around San Diego Bay, they can be confident of the fact this is essential, operationally-relevant training.


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Home > Black Mirror > Bandersnatch
Black Mirror: Bandersnatch (2018)
Critic Consensus: While Bandersnatch marks an innovative step forward for interactive content, its meta narrative can't quite sustain interest over multiple viewings -- though it provides enough trademark Black Mirror tech horror to warrant at least one watch.
Tv Season Info
News & Interviews for Black Mirror: Bandersnatch
Critic Reviews for Black Mirror: Bandersnatch
All Critics (61) | Top Critics (17) | Fresh (45) | Rotten (16)
Writer Charlie Brooker's take on the medium stands out from the bunch. Not only is it unlike anything you've ever seen in this medium, it also makes you think in ways that only a show as dark and existential as Black Mirror can.
It's fiendish stuff, but an undeniably clever new entry in the boundlessly reflective Black Mirror canon: the episode that never ends.
It's tech we're supposed to be able to boss around that bosses us around instead. In that way, it's a perfect Netflix show.
The question though is 'Is it any good as a film?' I'm torn between choosing 'YES' or 'NO.' Is there a third option?
A hard-to-define, but impossible to forget, experience.
In giving the viewer a smattering of choice, Black Mirror's most disturbing episode yet argues forcefully that none of us are really in control of anything.
Audience Reviews for Black Mirror: Bandersnatch
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Discuss Black Mirror on our TV talk forum!


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Five years ago, my younger sister (47) stopped talking to me. She won't answer my phone calls and answers messages with curt responses.
Our argument, over email, was her accusing me of two very hurtful things which I didn't do.
I'd told her she was out of line making terrible accusations without first speaking to me to learn the truth.
I've not been a perfect sister but I don't deserve this treatment.
Previously, we spoke regularly, spent all holidays together, and I included her in all our family gatherings.
Now, she'll have contact with my adult daughter but not me.
We came from an abusive alcoholic background, which may've had an impact. I see her pattern of envy and a very dysfunctional way of dealing with conflict.
It's happened before and wasn't warranted then, either.
How do I attempt contact with her or is my sister relationship over?
Frustrated Sister
You have understanding, insight, shared history, and personal will… so the answer is up to you.
There are some people who'd say, "She's toxic to me. I'm finished with her."
Well, this column has seen truly toxic relationships and this isn't one of them.
You accept that you haven't been the perfect sister. You know that the dysfunctional background you shared has affected both of you deeply (abuse, alcoholism, anger).
You're hurt but you don't want the relationship to be over.
So tell her that being sisters still matters to you. Tell her that you'll always tell her the truth about what she hears, so you two can keep connected and not let others drive you apart.
Of course, you could stand on principle instead, and insist on her apologizing before resuming any contact.
But you already know she can't handle doing that, because you do understand her.
Break into her silence. Tell her you miss her. If it works, it's worth it and what you obviously prefer. If not, you'll know you tried.
Reader's Commentary Regarding the father who blames his two university-age daughters' distance on their mother's "brainwashing," (May 3):
"All the responses posted by other readers, while valid, only showed one side of the story, that of a parent.
"Mine is a different, unique perspective - that of a grown, adult daughter of divorce who's cut off her father, a man who constantly harps on the "brainwashing" being done to her by her mother.
"I can tell this father that he needs to take a long look at the type of relationship he had with his daughters as they were growing up.
"Was he there for them unconditionally when they needed him? Did he put other things ahead of them, making them less important to him than his friends or activities he was interested in?
"Kids are smarter than most adults think. If they got the sense that he'd rather be with other people, or doing other things than being with them, then why would they think that would change when they got older?
"As for the brainwashing, their mother doesn't have to do that if his behaviour isn't telling them that they're the most important thing in the universe to him.
"He's doing enough of the brainwashing on his own.
"The more he blames their mother, the more he's insulting his daughters' intelligence, insinuating they're incapable of making up their own minds, and driving a wedge even further between them.
"Until, finally, his daughters cut all contact, with no hope for a reconciliation."
A Forgotten Daughter
FEEDBACK Regarding the wife's "I don't love you" pronouncement, on her husband's birthday (May 5):
Reader – "I suggest that, along with counselling, both parties get a complete physical.
"The reason: I've noticed that many times when a marriage breaks up with no other party involved, one of the spouses discovers shortly thereafter that they're seriously ill.
"The "something's-wrong" feeling that they blamed on the marriage was likely the undiagnosed illness.
"This isn't a clinically-proven reality but something I've observed in some relationship breakdowns."
Ellie – While yours is definitely not a clinical diagnosis, it's a thoughtful observation.
Experience through this column has shown that people who "suddenly" find fault with their relationship may be undergoing health changes which cause or add to fears, restlessness, depression, etc.
That doesn't justify accusing an unhappy partner of being "sick" when they express relationship concerns. But a health check is wise when such attitudes change very abruptly.
Tip of the day:
Siblings raised with abuse, chaos, and anger, can understand overreactions and try to forgive.


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Gentle Yoga for Adults, Morristown, NJ
January 29, 2019 –
Tuesdays, 1:00 - 2:00 PM
Yoga is helpful for dealing with stress, illness or injury. Relaxation techniques taught in class include breathing exercises and beginner's meditation.
Zufall Health Wellness Center
85 Washington Street
Morristown, NJ 07960
For more information and to register, please call 973-998-7310 ext. 286


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Wall Hanging Art Halloween Pumpkin Print Tapestry - W91 Inch * L71 Inch
Size W59 INCH * L51 INCH W79 INCH * L71 INCH W91 INCH * L71 INCH
Processing Time: Your item will be shipped out within 3 business days.
- Buyer protection|Learn More >>
- 30 Day Returns Guarantee
- Full or partial refund if the item is not as described
- Full refund for damaged items
- Made of 100% lightweight polyester
- Featuring vivid colors and crisp lines
- Multipurpose item used as the bed cover, table cover, photography backdrops, etc.
- Available in 5 distinct sizes
Theme: Halloween
Material: Polyester
Feature: Removable,Washable
Shape/Pattern: Pumpkin
Weight: 0.4200kg
Package Contents: 1 x Tapestry
- Receiving time = Processing time + Shipping time
- Priority Direct Mail: 7-15 bussiness days
- Standard Shipping: 7-25 bussiness days
- Expedited Shipping: 3-7 bussiness days
Our Guarantee: 30 Day Returns or Exchange guarantee from the delivered date.
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On her deathbed, Mrs. Dodd (Mary Chambers) makes her son Jimmy (John Cumberland) swear that he will provide for his sisters (Emily Lorraine, Inez Marcel and Frances Neilson) until they marry before making a home for himself. Since the sisters are selfish, spoiled and not particularly attractive, this takes quite a long time. As a result, Jimmy loses the only girl he ever loved. When finally the sisters are gone, Jimmy decides to live it up a little. But his attempts to enjoy life are pathetic, and his sisters are upset that he refuses to behave respectably. Jimmy, however, tells them to mind their own business. Nevertheless, this doesn't hide the fact that he has become a terribly lonely old man. This picture was based on a magazine story by Edna Ferber, and was adapted for the screen by Mrs. Sidney Drew.
Add this movie to your queue to receive more information about
Gay Old Dog and we will let you know when it becomes available.


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Metacycle is a project developed by researchers at Concordia University and the Université de Montréal. It is an online virtual community dedicated to the common objective of prolonging the life span of consumer products.
The Metacycle Team
Summer '08 Competition results
Re-Office Clock by Botelho & Gouveia
The designers succeeded admirably in producing an exciting new product by cleverly using a number of used up markers which would otherwise end up in the trash. There is a particular economy and elegance of means at work here. The markers are re-used without any disassembly or modification. Their application makes the most of one of their most attractive qualities, still present even when the ink is dry : the colour of the cap. This aspect is exploited to the maximum, even allowing the user to vary the look of the clock by changing the colours. The simplicity of the constructive elements that make up this concept also allows for a great number of design variants. These are ideally suited to the production of parts with Rapid Prototyping (RP) technology and will undoubtedly be explored in the development process that will now be undertaken. Even RP's limited range of material colourings is taken into account. A monochrome housing will not detract from the brightly coloured marker caps.
While necessitating the production of a clock mechanism and Rapid Prototyped housing to retain the markers, this concept shows how even such a mundane, ostensibly disposable product such as a marker, can be put to a new use and play a role in the confection of a new product.
Children's Game by StephG
Several proposals involved the re-use of a VHS cassette and this one made particularly clever use of the double spools and windows that characterize the product. The idea is both creative in itself as well as offering a creative outlet for young children. One imagines being able to make custom disks and thus increase the play value almost indefinitely. The idea was also thought to offer the potential of demonstrating simple mechanical systems through the use of add-on cranks, belts and gearwheels.
Jump at Light Speed by Botelho and Gouveia
This is Metacycling in its purest form. Taking advantage of a the flashlight's formal qualities making it well suited to use as a handle, the suggested transformation requires a minimal amount of added material: a length of cord. In most cases, the proposal can be realized without any tools although some models of flashlight would require drilling a hole through a non-removable lens.
Video Tape Dispenser by Botelho and Gouveia
This was a popular idea, not only with the judges but with contest participants as well : three proposals were received for transforming a VHS cassette into a tape dispenser. Although these differed in the way the tape was to be drawn and cut, the basic intent was the same, Botelho and Gouveia's proposal being the first posted. The idea is a clever way to make new use of an obsolete object, requiring only a moderate level of do-it-yourself skills to be carried out at home.
VHS Shelf by Jean-Sébastien Day
This could be qualified as a Metacycling adaptation of the age-old concept of bricks and boards shelving. VHS cassettes are clipped together to form a straightforward storage system for CDs and DVDs. What the judges found admirable in this proposal was the ecological efficiency of the concept, an effective way to make use of the whole cassette (no disassembly required) by producing a system of very small joining pieces. A very good application of Rapid Prototyping technology for ecological purposes.
Brush-You by Bueno&Muller
The jury could not help but be impressed not only with the creative re-use of old toothbrush handles, but by the elegant presentation of the idea. Cutting the plastic handles up and making them into jewellery beads completely rids them of any ties to their initial function while capitalizing on the colourful, snappy nature of the material they are made of. This could turn into the next big fad!
Sinkmate by venkat
While recognizing that this concept requires the production of a sizeable handle, the judges were impressed by its potential for creating a multi-purpose "brushing system" capable of re-using a large number of toothbrushes. "This is a Metacycling Machine" said one of the judges, referring to the fact that 'new' used brushes could be added as needed to replace those that became totally used up.
Air Fresh Hook by Dino
While several proposals were posted for re-using broken hockey sticks, this one was judged as the most likely to succeed since it served a purpose very closely related to the source of the material. Hockey players break their sticks on a regular basis and these same players need to dry their equipment. The re-use cycle therefore becomes very obvious, the distance between supply and demand being reduced to a minimum.
Kaleidoscope by octraine
The project of a kaleidoscope from an old flashlight seems like it would be more fun to do than to use, but if it keeps products from the trash bin, then it's worthwhile. Moreover, most of the material needed for the project could probably be found around the home (more Metacycling). A nice way to spend a rainy Saturday afternoon.
Marker-Pencil Holder by CarlosU
The judges thought this idea had the potential of becoming a classic Metacycling idea. It re-uses a large number of markers, makes use of their colourful nature in a way that is totally coherent with their original use and necessitates the production of relatively small new parts. The proposal was also very open-ended, having the potential to be expanded into a whole range of home or office products. More products offered, more used up markers are going to be re-used.
Sander by mbishop
Turning a computer mouse into a hand sander seems like such a natural transition. The smooth, rounded shape of the mouse is purpose made to fit the hand. And although sanding requires considerably more energy than steering a mouse, raising the housing off the sanding surface allows grasping the underside of the mouse and increasing the grip force. It was also appreciated by the judges that the inner components of the mouse were left in place rather than gutted and thrown away.
Below are some innovative solutions selected from
the ideas contributed by many metacyclers that have actually been given
a second life to old objects by using rapid prototype technology. Please
browse these featured solutions to explore the beauty of metacycling.
Education Tool
Sidetable Lamp
Table Lamp


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Cosmin TRG "Love 2 Hide"
Romanian future-garage (or whatever you want to call it, someone needs to name this genre soon) producer TRG (a.k.a. Cosmin Nicolae) recently made the decision to de-simplify his moniker, expanding it to Cosmin TRG. Following the change comes this exclusive download of "Love 2 Hide." The song's repetitive beat utilizes a number of classic drum sounds along with chopped-n-screwed vocal samples, ambient synthscapes, and a throbbing bassline, all of which add up to a solid club track. Chances are, when Cosmin TRG takes the decks during his appearance at the next FWD>> + Rinse event, he'll be playing plenty of equally tasty beats. Check out the party info here.
Love 2 Hide
Love 2 Hide


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What is growth?
How is it different than marketing?
Growth =working with Data and Analytics, Product, Marketing, Engineering, and Sales to increase revenue and customers sustainably and efficiently, typically via a combination of qualitative and quantitative data via systemized process and iterative agile testing.
- Drive both acquisition & retention
- Set up review & report on end to end analytics
- Review Performance of Cohorts over time
- Measure Churn, Retention Rate & Growth Multiplier
- Collaborate with Product to improve user experience
- Testing Cadence to boost conversion rates and efficiency of paid spend
- Familiar with both owned, earned and paid media
- Our team is heavily influenced by Growth Leaders like Brian Balfour, Andrew Chen and Alex Schultz
OUR process
Needs Assessment
Kick Off & Persona Development
Growth Diagnosis
Marketing Channel Assessment
Launch top highest priority revenue channel(s)
Focus on Impact & Maximize learnings
Test, Iterate, Optimize
How CAn we help?
Let's chat about your marketing and growth challenges.


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Ready to rock with Shawn 'Jay-z' Carter & Linkin Park?
Nominated for a Grammy this year for their groundbreaking collaboration Numb/Encore, the duo promise an electrifying performance on the big night.india Updated: Feb 08, 2006 15:02 IST
Multiple Grammy winner-rapper mogul Shawn "Jay-Z" Carter will perform with Grammy-winning rockers Linkin Park, for what is destined to be an electrifying performance. The two have been nominated for a Grammy this yearfor their groundbreaking collaboration Numb/Encore.
Newly announced presenters include Grammy nominee Alicia Keys and comedian-actor Dave Chappelle. Nominee AnoushkaShankar — up for Best Contemporary World Music Album (Rise) — will perform during the Grammy Pre-Telecast ceremony.
These outstanding artists join previously announced performers Mariah Carey, John Legend and KanyeWest — all with eight nominations each; Madonna with Gorillaz; Paul McCartney; Kelly Clarkson (who also is an honorary member of The Academy's What's The Download® Board); Bruce Springsteen; U2 and Mary J. Blige; Coldplay; Faith Hill and Keith Urban; Christina Aguilera and HerbieHancock; Sugarland; Jamie Foxx with Kanye West; an all-star tribute to Sly And The Family Stone featuring Maroon 5, Will.I.Am of The Black Eyed Peas, Robert Randolph, Steven Tyler and Joe Perry of Aerosmith, Joss Stone, John Legend, Ciara and Devin Lima; and nominee Hezekiah Walker & Love Fellowship Choir join Mariah Carey.
Previously announced presenters include Big & Rich, Chris Brown, Michael Bublé, Common (who also is an honorary What's The Download Board member), Jenna Elfman, Destiny's Child, Matt Dillon, Tom Hanks, Teri Hatcher, Jennifer Love
Hewitt, Terrence Howard, Queen Latifah, Ludacris, Bonnie Raitt, and James Taylor.
As previously announced, hosting the Pre-Telecast are revered rock guitarist Steve Vai and TV personality Giselle Fernandez; presenters for the Pre-Telecast include nominees Jars Of Clay, Shirley Caesar, Nnenna Freelon, Delbert McClinton; and K-Mozart radio personality and conductor/composer John Santana.
Pop vocalist Michael Bublé will be featured in a performance during the Pre-telecast as well.
The Grammy Awards will take place on Wednesday, February 8, at Staples Center in Los Angeles and will be broadcast in HDTV and 5.1 surround sound on the CBS Television Network at 8 p.m. (ET/PT).
First Published: Feb 08, 2006 15:02 IST


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It's nearly impossible to keep up with all the changes Google makes and refines with its algorithms and product updates, but one that's holding the attention of all marketers across various industries is Google's removal of text ads from the right-side of the search engine results page (SERP).
Google made a minor change to the layout of the results by copying the mobile layout. The mobile layout keeps all the content in a single column to fit the device the user is on whereas desktop ads previously had more space to spread out, thus meaning more ads were showing to desktop users. Google has now condensed all results to one single column across all devices. Let's take a closer look.
See how Google used to look with ads (red) and organic listings (green):
Now, see how it looks:
So why is such a seemingly small change captivating marketers? Well, it's for sure going to impact Cost-Per-Click (CPC or PPC) advertising and advertising budgets but it also gives us insight into future Google changes. Google is on a quest for quality, both from an organic results standing and now from an advertising standing by giving real estate to high value and relevant ads. It also reaffirms Google's shift toward mobile by making every experience on Google mobile-friendly, no matter the device.
How does this impact your hotel?
- Expect PPC cost to change: Right now, it's expected that PPC budgets will need to be increased to remain competitive as there's less space devoted to ads in the SERP. By removing right-side ads, ads are now condensed in the main column with four placements, where prior it would be two ads in the main column and four ads on the right-side depending on the search.
- Branded ads may perform better: Your branded ads will still maintain a high quality and relevancy score and your competition may not be so keen to bid on your terms at a more costly rate.
- Keyword changes: On the flip side, it'll be harder for smaller brands to bid on expensive generic terms like "beach resort." The cost for these generic keywords could add up quickly. At RezStream, we'll continue to focus on bids on specific terms, like "hotels in downtown Denver" to remain competitive.
- OTAs to benefit: Love them or hate them, OTAs have the advertising budgets to work within this new layout and we expect to see their ads getting some of these coveted ad spots.
What you can do:
- Don't panic!: Our friends at WordStream found that about 85% of advertising clicks came from the top ads anyways and about 15% came from the right-side ads. This gives you an opportunity to craft highly relevant ads and use your keywords strategically.
- Focus on organic SEO: Focus on your organic SEO efforts whether that's updating information or your site or publishing blogs and make sure your site adheres to Google's quality guidelines. This includes having a mobile-friendly site, quality content that has E.A.T. (expertise, authoritativeness, and trustworthiness) and answers the search query, and there's no duplicate content.
- Use ad extensions: Ad extensions allow you to extend your text ad with extra information such as your location, reviews, additional sitelinks such as a contact us or specials page, callout extensions, and more. Use these to get people to specific pages of your site faster.
What do you think of this change by Google? Share your opinion in the comments section below!


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Induction Motor Bearing Fault Detection under Transient Conditions
Pages : 1287-1292
Download PDF
This paper introduces a method for diagnosis of bearing fault of induction motor under transient conditions. The q-axis component of the stator current signal is decomposed by using the discrete wavelet transform (DWT). The fault detection method is developed by using the artificial neural network (ANN) to identify the motor state. A dynamic model of the squirrel-cage induction motor taking account the bearing faults is developed using simulink/matlab. Simulation results show that the better performance of the proposed method.
Keywords: Induction motor, bearing fault, MCSA, DWT, ANN
Article published in International Journal of Current Engineering and Technology, Vol.3,No.4(Oct- 2013)


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Shakopee Derby Days Shakopee Derby Days
Here's a sample of our volunteer opportunities:VIEW AS
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Mission Statement
Our mission is to plan and implement an annual community festival that brings residents, businesses and visitors together to celebrate the past, present and future of Shakopee.
The Shakopee Derby Days Committee is an all-volunteer non-profit organization that puts on an annual community celebration (Shakopee Derby Days) with several events happening over a five-day period. We have events ranging from entertainment, family fun park, Taste of Shakopee, market fair, fireworks, parades, senior Olympics, 5K, and much more.
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Request administrator status and update its information!
Would you recommend Shakopee Derby Days?


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"My inspiration is real women," revealed the Venezuelan designer. The line features ultra-feminine pieces with belts tied at the waist and a fullness in skirts reminiscent of the fifties.
We like the structured lines with sleeves that are fitted to the elbow, then voluminous to the wrist. And we love Caroline's winged skirts, which follow the curves of the legs but have exaggerated pleats at the back. The textiles in the line include wool, cashmere and tweed, in dresses, suits and coats.
Red, orange, pale pink and beige bring a note of color to the black and gray that dominates this new line.


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St. Mary of the Mills strives to
- Form students who are followers of Christ through discipleship by witnessing to the Gospel message as understood, taught, and proclaimed by the Catholic Church in both word and deed.
- Help everyone achieve educational and personal excellence in spirit, mind, and body by encouraging all to explore and develop their God-given gifts and talents while embracing and celebrating our differences.
- Inspire life long learning in a loving, secure, caring, respectful Catholic community by modeling the example of Christ as servant leader.
- Foster the relationship between administration, faculty, staff, and parents understanding that Catholic education is a partnership where the parents accept the responsibility as the primary educators of their children while the school provides the formal education of the students.


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In this post i want to tell you about 3D tree models. To make your house plans to build your home sweet home. This makes 3d tree models one of the most popular ornamental plant 3d models used by 3d modeling artists for 3D landscapes in 3D model architectural scenes, still renders, 3D city scenes model, and 3d visualizations.
"How do you choose the right tree 3d model for your landscape?"
For example, to select the appropriate 3D palm tree model, let's first take a look at what sets palm trees apart from other trees. Whether it is a Palm Tree 3D Model, low polygon or high polygon or Desert Palm Tree 3D Model, low polygon or high polygon/high res, it does not matter.
Therefore, the first step in selecting your palm tree 3d model is to determine whether your landscape's climate is tropical or subtropical. For example, if you are 3d modeling a casino in Las Vegas, then you would choose a desert palm tree, such as the True Date Palm Tree, for the landscape.
- Mediterranean (European) Fan Palm
- California Fan Palm
- True Date Palm
- Queen Palm
- Canary Island Date Palm
- Texas Sabal Palm
- Windmill Palm
- Pindo Palm
- Sago Palms
- Mexican Fan Palm
Once you know what type of 3d model trees you need, simply get the stock 3d palm trees. Look at the picture bellow to see more perfect 3D house model for yuor perfect home ideas.


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New at Envy Skin Clinic: Venus Concept!
May 14, 2012
The demand for non-invasive aesthetic treatments has increased dramatically in the past few years. Today, we demand effective treatments that deliver excellent clinical results and that are comfortable and safe.
Venus Concept Freeze® is a revolutionary technology that offers non-invasive skin tightening, cellulite reduction and circumferential fat reduction. Freeze® treatments have grown quickly in popularity even drawing the attention of America's Next Top Model where it will be featured next season.


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Ouch disability talk show 107: Mental vacuum
On this month's show: Meet The Vacuum Cleaner, also known as artist and activist James Leadbitter. He invites you to help him design the perfect asylum and talks about the time he wrote his own mental health act then sectioned himself under it.
Also: Mik Scarlet joins us for topical chat, a quiz, and three more citizen correspondents bring you their disability news.
Rob Crossan and Kate Monaghan present.
With interviews and topical chat, Ouch loves to explore the little things in disability life. Find it on this website monthly.
How to listen
Click to listen immediately on Audioboo
Subscribe to Ouch as a monthly podcast on iTunes and other services. Or click the play button on this page (low bandwidth version)
Show notes
Find out more about this month's guests and discussions with our selection of links.
- James Leadbitter AKA The Vacuum Cleaner talks about his project Mad Love. He's touring the country asking people to create their own designer asylum.
- Broadcaster, journalist and access consultant Mik Scarlet joins us.
- Our citizen journalists on the show this month are Wendy Morrell (assistance animals), Kathleen Hawkins (prosthetics) and Lisa Egan (TV).
- Music this month is from Tralala Blip. It's called Soccer in Space (click the link to watch the video). The band is from Australia and all members have learning difficulties... except Randolf.
For other audio clips from Ouch, go to our Audioboo channel.
Producer: Damon Rose
Follow @BBCOuch on Twitter and on Facebook, and listen to our monthly talk show


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Dr. Bosacker has 19 years of experience as a physician, both in the military & private sector.
Let her put her knowledge to work for you and your viewers.
Dr. Bosacker's expertise encompasses the full scope of clinical medicine. She has worked with patients of all ages in many different settings.


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How to Eliminate Pest in an Ecofriendly Way
4 Natural and Free Ways to Eliminate Pests
We are all concerned with the impact of pesticides, not only on the environment but also on the human race. The stories of 2 headed fish, frogs with extra legs and reptiles who carry both male and female reproductive parts have us all concerned about the impact of pesticides. No one wants to wake up one morning only to find that their vision has improved with the addition of a third eye growing out of their forehead.
The following tips are not for the faint of heart, but were instrumental in eliminating pests from my home. Actually, some may consider these methods worse than the pests they are trying to eliminate. If you are not squeamish you may give these methods a try. They were effective in creating a pest free home.
Problem: Insects
Growing up, my Dad was adamant that we not disturb the spiders that took up residence on our porch. He insisted the spider webs worked better than fly catchers. At that time he was the only one in our house to believe that spider webs could be used a biocontrol. However, now that I am a homeowner myself, I have come to appreciate this environmentally friendly way to get rid of pests.
Most people have a negative reaction to spiders but they are a wonderful way to control the insect populations. Spiders are predators that consume a multitude of insects. Some build intricate webs to catch their pray, while others simply wait to pounce on a tasty insect.
Don't be afraid to leave those webs up. It may even cut down on the time spent decorating your porch for Halloween.
Problem: Small Rodents
Solution: Black Rat Snakes
I used to have a small rodent problem at my house…until I didn't. I was quite happy to be done with the rodents and didn't give much thought to what had solved my problem. I assumed they liked my neighbor's house better. That was until I was enjoying a cup of coffee on the back patio and noticed the grass moving in a slithery sort of way. Yes, it was black snake. Apparently, he had taken up residence in the crawl space under my house. That explained my lack of rodents that had plagued my house in the past.
Many non-venomous snakes are constrictors that will consume small rodents. If you can get past an instinctive fear of snakes they really aren't too bad to have around. There could be worse things living under your house.
Problem: Ants
Solution: Armadillos
At one point my yard was plagued with ant hills that were filled with irritating Fire Ants. Over time the hills began to mysteriously disappear and my shrubs were inexplicably uprooted.
I had been suspicious that a creature of some sort was living under my front porch. I was however reluctant to explore that dark space under the porch to identify the creature. It could have been a snake! The mystery was solved when I came home late one night and saw an armadillo strolling out from under my porch. I now had an explanation for the uprooted shrubs and the disappearance of ant hills from my yard. Armadillos love ants.
Armadillos like to dig for their food and will eat just about anything: plant or animal. They do have the potential to cause damage to landscaping when rooting around for ants. Additionally, Armadillos can carry the bacterium that causes leprosy, salmonella, the rabies virus and also tape worms. You know, forget about the armadillo. If one takes up residence under your porch, just call animal control.
Problem: More insects
Solution: Frogs and Lizards
If you have more insects than the spiders can handle alone, get a frog or lizard. Who doesn't love a cute little frog or lizard? They love to eat lots of insects. On the plus side, these natural predators won't freak out your friends and family if they see them around your house.
The natural pest control methods listed above may not be for the average home owner, but they can be effective. You can save money and keep chemicals out of the environment by relying on natural predator-prey relationships.


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It's with a heavy heart that I must say farewell to an old friend…for now.
I began dabbling in Linux since the early 90s and went all-in about seven years later when Ubuntu really started to shine. Linux has really matured into a beautiful and stable operating system over the years. I've participated in countless Linux-related projects and I believe in the open source foundation of Linux. It has always been that perfect OS for me.
My decision to switch to Mac came down to one thing: compatibility. While there are well-capable Linux versions and equivalents of 99% Windows/Mac software out there, there is one wall that I just can't break down: Photoshop and Lightroom. I practically live in these two apps and getting them to work smoothly in Linux has been like pounding the proverbial square peg into a round hole. And Adobe just refuses to extend these industry standards to Linux users because they think we're cheapskates. So I've had to struggle with launching the big Adobe apps in VMWare virtual Windows machines running inside Linux. Believe me, this has been nothing but a recipe for frustration. I could have purchased ten Photoshop and Lightroom licenses for the money I've poured into getting them to work in Linux.
Somehow Macs have always eluded me even though I can breeze through the deepest crevices of every version of Windows, OS2, UNIX, DOS, Commodore, and even Atari 8-bit. Maybe it's the closed-platform architecture. Maybe it's the cult-like throngs of Apple evangelists. There's no bigger turnoff than fanboys who feel the need to be cheerleaders for their big corporation of choice. I'm not looking to join a particular OS religion, I just want what works best for me.
After a few hours in the Apple store, I realized one thing: Mac and Linux are like twin siblings separated at birth. The directory structure, the unix command line, and the interface–it's all so similar and identical in so many ways. Of course, with Apple you get the pretty packaging, the polishing, the well-integrated hardware, the price tag, and what I needed, the Adobe compatibility.
So I did it. I ordered fully-loaded and maxed-out iMac. I was going to wait for the new line of Mac Pros, but the new top-of-the-line iMacs seem to have the necessary performance. I'll be pairing the 27″ monitor to my existing big monitors for a triple-monitor desktop. I could hear the echoes in my mind as I clicked the confirm button: "good gravy, what have I done?…"
This isn't really goodbye–I'll still be running Linux on my laptop, netbook, server, and TV media client machines. But the nucleus of my computer time–my desktop–is getting the big switcheroo.
Viva la Linux! You'll always hold a special place in my heart. Sniff, sniff….


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HDPE Pipe Lining & Trenchless Technology
In the past, problems caused by aged and damaged sewer and stormwater lines meant digging up and repairing or replacing each section of pipe that needed attention. Completing repairs this way is labour-intensive and costly, not to mention destruction to the surrounding landscape. Now, thanks to modern pipeline trenchless rehabilitation technologies like HDPE pipe lining repair and pipe bursting, we have a cost-effective and more sustainable way to go about repairing pipelines.
Pipe Lining vs. Pipe Bursting
When it comes to trenchless technology, there are many different methods to choose from, the most common of which is pipe lining or pipe bursting.
Pipe Lining: This involves pulling or inverting a new HDPE liner into an existing pipe, then applying heat and/or pressure to force the liner to expand and fill the pipe.
Pipe Bursting: This involves fracturing a pipe from the inside and forcing the fragments outwards while a new pipe is drawn in to replace the old pipe
4 Benefits of Trenchless Technology
- Saves Time and is More Convenient: Traditional digging methods take substantially longer than using trenchless technologies, making it more convenient and quicker to resolve problems associated with damaged pipelines.
- Saves Money: Using trenchless technology is less expensive because structural modification (i.e. taking out walls) is not required and less technicians are needed to complete the job faster. In addition, no heavy equipment is necessary, which in turn also reduces clean-up costs.
- A Less Intrusive and Environmentally Friendly Alternative: No digging means minimal ecological damage as it eliminates the need to dig up the earth and affect surrounding landscapes.
- More Durability with HDPE Liners: The use of an HDPE pipe liner in trenchless technology helps to protect the pipeline with greater resistance, adding more durability and prevent further leakage and damage to the pipe.
The installation of MEGATUFF HDPE Pipe using trenchless technology is rapidly growing as a preferred method of rehabilitating pipelines in the construction and civil engineering space because of the many benefits it presents in terms of cost-effectiveness, minimised environmental impact and safer procedures.


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The iShade Sundance folding arm awning stylishly extends your living area by acting as a retractable, fabric roof. Its slimline headbox gives the awning a neat, compact appearance when tucked away, and also prolongs the life of the fabric. The Sundance allows you to create an outdoor area ideal for barbeques, entertaining and weekend fun.
iShade's strong design provides a high-quality folding arm system with simple and reliable operation. The Sundance boasts a modern look with the durability to last, enabling you to make the most of your outdoor space. Effective sun protection with iShade's surprising good looks.
Sundance - Folding Arm Awning Specifications
|Min Width: 1930mm
Max Width: 7975mm (depending on fabric choice)
Extension: 1500mm, 2000mm, 2500mm, 3000mm, 3500mm
Maximum extension is dependant on width
pitch between approximately 0-45 degrees at installation
|215mm (h) x 180mm (d)
|Folding Arms
|Folding Arms tensioned with protected stainless steel wires
|Fabric Pitch
|For rain protection a minimum fabric pitch of 20 degrees is required
|Motorised RTS (remote control)
Motorised hardwired
Manual crank (removable external crank handle)
|Aluminum frames, Galvanised fabric tube
|Stainless steel bolts, nuts and screws
|Frame Finish
|Powder Coating (All Standard Dulux and Interpon colours)
|Fabric Choice
|Soltis 86%, 93%
Sunworker 90%
Acrylic 99%
|Decks, patios, uncovered outdoor areas
|Sundance product brochure (1.5MB)


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...compare and contrast.
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Helping the Filipinos vs "helping the Filpinos"...
Discuss culture, living, traveling, relocating, dating or anything related to the Asian countries - China, The Philippines, Thailand, etc.
Moderators: fschmidt, jamesbond
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2 posts • Page 1 of 1
Check out our Dating Sites and International Romance Tours!
Re: Helping the Filipinos vs "helping the Filpinos"...
I didn't watch all of either video. I think the guy who makes the first video was mentioned in discussions on here before. I think he gets money from western men who want to date young Filippinas, uses it to feed the girls and record himself talking to them and flirting with them. Then he meets the guys up with the girls and may pressure the girls to date these old guys.
The girl in this video looks like a high school student. It looks like his business model is about getting high school and young college girls who want free food to go to restaurants and events so that if white people send money or visit, he can have some girl to show them. It seems like a formula for attracting two-bit (two-peso?) gold diggers. If a man wanted to date a Filippina and visit her, wouldn't he be better off to do it online without hiring a guy to take the girl out and flirt with her on his behalf?
Helping the woman in the second video sure looks a lot more like 'helping the poor.'
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2 posts • Page 1 of 1


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Online Clearance Sale!
Our new merchandise for AirVenture 2017 is delivered, tagged and filling up our IAC Pavilion store in Oshkosh!
We need to clean our closet and make room for the new items and no better way to do it than to offer it to you at a super discount.
When you buy online, you'll save 25%-40% off the retail price. Check out all of the discounted items HERE.


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Isolation and characterization of resistant gene analogs in cassava, wild Manihot species, and castor bean (Ricinus communis)
TypeJournal Article
Review statusPeer Review
AccessibilityOpen Access
MetadataShow full item record
Gedil, M., Kumar, M. & Igwe, D. (2012). Isolation and characterization of resistant gene analogs in cassava, wild Manihot species, and castor bean (Ricinus communis). African Journal of Biotechnology, 11(85), 15111-15123.
Permanent link to cite or share this item: http://hdl.handle.net/10568/80861
Cassava, Manihot esculenta, is one of the major food crops in sub-Saharan Africa (SSA) providing the bulk of dietary calories to hundreds of millions of households. Two viral diseases, namely cassava mosaic disease (CMD) and cassava brown streak disease (CBSD) pose a serious threat to cassava production. The emergence of new virus species and strains that overcome the existing resistant/tolerant cultivars entails identification and pyramiding of new sources of resistance using marker-aided selection. The isolation of resistance gene analogues (RGAs) using a homology-based approach can provide useful resources towards this goal. Degenerate primers based on the conserved motif of the nucleotide binding site (NBS) domain from resistance (R) genes were used to isolate RGAs from genomic DNA and cDNA in cassava, wild Manihot species, and castor bean (Ricinus communis). A total of 552 RGAs sequences were identified and deposited in GenBank. Conserved motifs such as P-loop, Kinase-2a and GLPL were present in the NBS domain. This study sheds light on the nature of NBS- leucine-rich repeat (LRR) R genes in cassava and closely related taxa in the family Euphorbiaceae. These candidate sequences mapped to the draft cassava genome with high sequence similarity to predicted NBS-LRR genes. These novel sequences may serve as a stepping stone for further characterization and experimental validation of predicted R genes in the draft cassava genome, ultimately leading to the development of functional gene-targeted markers that can be used in molecular resistance breeding aimed at combating CBSD and CMD.
CGIAR Affiliations
AGROVOC Keywords
RegionsAFRICA; WEST AFRICA
- IITA Journal Articles [1807]
- RTB Journal Articles [656]


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The core of all effective leadership really comes down to this. It all has to make sense. Everyone has to be able to start with "I think...". Not "Mr. X says..." Not "policy is.." Not "I was told..." but "I think..."
For this to work, leaders have to be firmly grounded in a shared vision and they have to be committed to maintaining integrity in the sense above. Values, principles, objectives, strategies, communications, performance evaluations, policies, processes, commitments all have to be constantly integrated. Leaders who force themselves to be able to say "I think..." before a comprehensive view of all of these things can lead from the core. Just as it is painful to do the exercises to strengthen your physical core, so it can be painful to maintain core leadership strength in this sense. It is very easy to get "out of shape" by neglecting core values, objectives, strategy and execution alignment. But without a strong core, none of the most important leadership attributes - authenticity, inspiration, strategic vision, followership, transformational impact - are possible.
Leaders who "skip the abs work" can get some things done and, depending on their good fortune and / or cleverness, some achieve material success. But no one remembers them. No great change is ever led by them. No great leaders are ever developed by them. Leading durable transformational change and developing great leaders requires core strength.
So how do you develop core strength? A great mentor and an already established values-based vision and strategy can help get you started, but you always end up having to do the work to build your own core yourself. Here are some little exercises that can help. There is nothing particularly deep here and there are lots of variations on these practices. The point is to regularly and critically focus on core integrity.
Look-back sit-ups. Starting once a week and working up to once a day, look back on all of the decisions, communications and interactions that you had and explain how it is possible that one person did all of these things. I guarantee that if you are really observant and critical, you will find lots of little inconsistencies - things that in retrospect you can't say, "I think..." in front of. For each of these, you have two choices: either come up with an alternative course of action that, had you done it, would have made sense; or modify whatever aspects of your vision, strategy or values it is inconsistent with (or more precisely, resolve yourself to conceive and align the necessary changes with your team, your peers and your leadership). Done honestly, this is painful. Think of each example as a little integrity sit-up. Here are a couple of concrete examples.
- Suppose that last week you negotiated an extension to a service contract. In exchange for a healthy rate reduction, you doubled the term length and added minimums to the contract. This will help achieve your annual opex reduction goal; but your agreed upon strategy is to ensure supplier flexibility and aggressively manage demand in the area covered by the contract. Your decision basically said near-term opex reduction was more important than flexibility or demand management. Either your strategy was wrong or your decision was wrong. To be one person, you need to either acknowledge the mistake or harmonize the decision with the strategy.
- Last week you agreed with your leader and peers in a semi-annual performance ratings alignment meeting that one of your direct reports was not fully meeting expectations in some key areas. You agreed to deliver the "needs improvement" message in these areas in his performance appraisal and to adjust his overall rating downward. You did change the rating and some of the verbiage in the assessment; but when you delivered the review and he challenged the overall rating, you were swayed by his arguments and in the end you admitted that you had been told to adjust the rating downward. Here either you failed to consider everything when agreeing to the rating adjustment or you were overly influenced by the feedback.
Virtual 360 crunchies. Again starting once a week and working up to daily, imagine you are specific person on your team, in your company or a partner (alternate among randomly chosen people from these groups) and respond to the question, "What is most important to X?" where X is you. Don't just repeat goals or big initiative names or repeat your own communications. Actually try to imagine what it would be like being the selected person and what they really think is important to you and how that relates to what they do on a day to day basis. Think about how they would say it in their own words, not yours. If you can't do it, or what naturally comes out is far from what you see as your core, you have two options. Either you have a communication problem - i.e. there is no way this person can have a clear understanding of what is important to you because you have failed to communicate it - or you don't make sense from their vantage point. In the first case, you need to work on communication and in the second, you need to patch whatever holes exist in your vision, strategy or values that make you incomprehensible to this person. Here are some examples.
- You have recently been promoted from a marketing leadership position to leading an entire business unit, including sales and operations. You have communicated your growth strategy, which is heavily top-line focused. You are also facing significant cost containment pressure. You know that learning about operations is critical to your success and you have been asking a lot of questions of your operations leadership team, focusing on quickly identifying some areas where you can cut costs. Your broad-scale communications have made high level references to "operations excellence" and "empowerment," but you have not provided any details on your plans for operations. Now suppose your randomly selected person for virtual 360 is a first level manager in operations. It is hard to imagine that she would not say that what you care about is top line revenue growth and cutting costs and what she does on a day-to-day basis is "not important to you."
- You are a well-respected leader of a software engineering team. There are 10 products in your portfolio. You have developed a robust set of goals for the organization, cascaded effectively through the team. There are 5 top-level goals, each of which has been broken down by each of the teams in your group. You know every product and team inside out and you regularly do "deep dives" at the product level. Your communications are detailed, often focusing on knowledge-sharing across the group and encouraging collaboration among teams. Imagine that the virtual 360 candidate is an engineer working on one of the products. He might say something like, "Let me go look at the goals statement. I know the features we are working on are important because she mentioned them in the deep dive last week."
I have never met a leader who did not have small or large "core integrity" problems to deal with from time to time. The great ones recognize them quickly and get whatever help they need to build and maintain a strong core.


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Matt Lauer suggestion starts starry Sandy telethon
The 'Today' anchor went to NBC Universal CEO Steve Burke, urging action; Bruce Springsteen and Bon Jovi quickly signed on.
NBC Universal is hastily organizing a one-hour telethon Friday to raise money for victims of the storm that has battered the East Coast.
Hurricane Sandy: Coming Together, airing live (with no audience) from Rockefeller Center Friday at 8 ET/tape-delayed PT, will feature a mix of electric and acoustic performances by Bruce Springsteen and the E Street Band, Billy Joel, Jon Bon Jovi, Sting, Mary J. Blige and Christina Aguilera. Some have ties to the New York and New Jersey areas hit hardest by the storm.
Appearances by Kevin Bacon, James Gandolfini, Jon Stewart, Tina Fey, Jimmy Fallon and news anchor Brian Williams are planned.
Today's Matt Lauer, who is hosting the broadcast, said in an interview that a Tuesday tour of a neighborhood in Rockaway Beach, Queens, after seven hours on the air, made him urge NBC Universal CEO Steve Burke to orchestrate the event.
That neighborhood lost 50 first responders in the Sept. 11 terrorist attacks; two months later, an American Airlines jet crashed there; now it's suffering again.
"I came back and said, 'We've got to do something quickly here,'" Lauer says. "I feared facing a period next week where the focus would be blurred. We've got an election coming up, and I feared people affected by this would be pushed to the side."
His first call to Burke came Wednesday at 6:45 a.m.; by 4 p.m., artists led by Bon Jovi had already committed. Williams personally called Springsteen, who's on tour. Both singers are from areas of the Jersey shore that suffered the worst damage.
Unlike many TV rivals, "we're a very New York-centered media company," Burke says, "and you can't live in New York without being struck by what a big thing this is."
Burke hopes to raise "tens of millions of dollars" for relief efforts. NBC backed a similar 2005 telethon, also hosted by Lauer, after Hurricane Katrina, raising $40 million. A post-9/11 telethon arranged by George Clooney, which aired on all the major networks, raised an estimated $200 million.
Friday's special will air on NBC, its owned cable networks including USA, Bravo, Syfy, E! and MSNBC, and on HBO, Discovery Fit & Health and Velocity, as well as Sirius XM Radio. It will also be streamed live on nbc.com.
Lauer says the special will include footage of the affected areas to help spark donations to www.redcross.org or (800) RED-CROSS. "But what's going to be most compelling is not me asking people to pick up the phone, but watching Bruce Springsteen and Jon Bon Jovi and Billy Joel playing their hearts out," he says.
Will Springsteen play 4th of July, Asbury Park (Sandy), a 1973 song about a girl and the boardwalk? Lauer wouldn't say. But "the songs are going to be instantly recognizable."
Among other efforts, Disney ABC is donating $2 million to relief efforts and has designated Monday as a "day of giving" across its news and entertainment programming, which will encourage viewers to donate. Viacom, which owns MTV, Nickelodeon and Paramount Studios, is donating $1 million.


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Artscape Festival10 7 Share Tweet
The largest public arts and music festival in Baltimore (happens every summer).
Artscape is apparently, the largest free public art festival in the country according the event organizers. The artists come from all over the county to showcase their work , be it paintings, pottery, clothing, glass and metal work, car art, sculptures, and even interactive human art scenes. I took shots ranging from the 3-D paintings coming out of the canvas to crazy decorated cars: The Cars Of Artscape to the historic area it's located in, Mt Royal. The festival also has three stages of musical and film performances featuring a variety of different musical groups.
This year CAKE played on the main stage for FREE!!! But if you're not into CAKE, no worries; they also have many other musicians playing a variety of music ranging from jazz, blues, pop and even some blue grass. Whatever you're into I'm sure Artscape will have something for everyone!
written by ssamm66 on 2009-08-05 #places #art #music #food #shopping #festival #crafts #streets #sunny #outdoors #painting #location #fuji-sensia #klick-max-200 #lomo-lc-a-race #artscape #mt-royal #urban-adventure


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HORSESHOE TRAIL // Bernbaum Magadini Architects
The Horseshoe Trail residence, nestled among large oak trees, provides a sanctuary for an "empty nester" couple. Their aim in designing the home was for open spaces in which to entertain family and friends. Mission accomplished with the kitchen and family room opening onto the lap pool and backyard allowing for dramatic views. These dramatic views are also seen from the library outside the master suite which provides the perfect space for more intimate pursuits such as reading. Throughout the home, large open expanses of wall showcase the owner's photography.
ABOUT THE ARCHITECT | Bernbaum Magadini Architects
Bernbaum Magadini Architects was established in 1998 although founding partners Bruce Bernbaum and Patricia Magadini's friendship goes back to their days at the University of Arizona. Together they pride themselves in designing architecturally modern homes - warm, livable environments for today's modern families. A staff of eight architects and intern architects work together on new homes, addition/renovations and small commercial projects.


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CPI(M) promises to increase minimum wages to Rs 15,000 if voted to power
The CPI(M) gave assurance in its draft manifesto to take steps to increase the minimum wages of labourers to Rs 15,000 if voted to power. The move comes at the time when the erstwhile Left Front government had not revised the same based on the factors like calorie quotient requirement in its tenure of 34 years. As a result, a few months after the change of guard in the state, the minimum wage had to be increased by 34 per cent in one go. The false promises of the erstwhile government came to light after senior officials from the State government said that the "pro-poor government" in three decades didn't take encouraging steps to increase the minimum wages of labourers by a decent amount. This has deteriorated the conditions of the wage earners in the past three decades. They had gone from pillar to post to increase their wages hoping that the Left Front government will honour their words. After the TMC government came to power in 2011, steps were taken to increase the minimum wages of workers in various sectors.
Following necessary studies conducted by a national institute of hygiene in Hyderabad, the calorie quotient has been increased from 2200 calories to 2700 calories per person. Fixing of the calorie quotient is one of the main criterions to revise the minimum wages after every five years. In doing so the calculation by the experts had shown that there was a need to increase the minimum wages by 34 per cent, an official of the State Labour department said. Minimum wages can be revised in two ways, firstly, in every six months and secondly after every five years.
The revision after every six months is mainly based on the immediate effects of the rise in the essential commodity price while the revision after every five years may take place based on calorie quotient and several other factors.
When TMC came to power, the minimum wage was around Rs 6,600 and with the increase of 34 per cent the amount has now gone up around Rs 10,000 plus. The official added that steps were taken to 'strictly implement' the revision in the scale of minimum wages since September 2011 and the next revision is expected to take place in 2017.
Earlier, there were 61 sectors in the minimum wages net. Now the number has gone up to 91 sectors. The new sectors include garments manufacturing industry, sponge iron and biscuits manufacturing industry.


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Stream Soopafly Feat. Daz & Kurupt "Move Too Fast" Video, the latest video from Soopafly, which dropped on Wednesday, September 14th, 2011. Soopafly's odds keep getting better with each new leak, and Soopafly Feat. Daz & Kurupt "Move Too Fast" Video will undoubtedly improve his chances of winning. It's a worthy addition to a respectable catalogue that has seen a lot of growth since Soopafly debuted in this game. We're looking forward to the follow-up.
Who else would you like to have seen on this video?
How do you feel about the production here?
Did y'all catch Erupt's latest visual for Erupt "Art of Beat Making" Video?
Hit up !A A A's profile page for the latest info, news, songs, and mixtapes.


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WELCOME TO Staack's Motorsports
Staack's Motorsports of Butte, MT invites you to check out our new and pre-owned Suzuki motorcycles, scooters, and ATVs, including the Hayabusa, GSX-R, Boulevard, V-Strom, RM-Z, DR-Z, Burgman, Ozark, QuadSport, and KingQuad. See the latest Suzuki special offers, schedule a service appointment, order parts, receive financing, and learn all about great deals that Staack's Motorsports of Butte, MT can offer you on new and used motorcycles, scooters, and ATVs.
102 E. Galena, Butte, MT, 59701-1826


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Taxation of long funding leases: long funding operating lessors: lease terminates as expected; part 1 of 2
Assume that the asset in the example in BLM41020 is sold for what turns out to be its market value of £7,000 at the end of year 15 and that nothing is paid to the lessee, even though the market value exceeds the expected value.
Step 1 is to find:
- the termination amount (TA, see BLM41050). In this case the asset is sold at the end of year 15. This sale would have been a disposal event had the lessor claimed capital allowances and it occurs as a result of (or in connection with) the termination of the lease. Therefore the termination amount (TA) is £7,000.
- the total of any sums paid to the lessee that are calculated by reference to the termination value (LP). The termination value is defined in CAA01/S70YH but as nothing was paid to the lessee, in this case LP is 0.
Step 2 is to find:
- the starting value for the purpose of CTA10/S363-365(SV). In this example it is £20,000.
- the total of the deductions allowable under CTA10/S363-365 (TD1). In this example it is 15 x £1,000 = £15,000.
- the amount (ERV) by which SV exceeds TD1. In this example it is £5,000.
Step 3 is to find:
- the amount of any additional expenditure for the purpose of CTA10/S366-368 (TAE). In this example it is £5,000.
- the total of the deductions allowable under CTA10/S366-368 (TD2). In this example it is 10 x £400 = £4,000.
- the amount (EAE) by which TAE (£5,000) exceeds TD2 (£4,000). In this example it is £1,000.
Step 4 is to:
Add ERV (£5,000) and EAE (£1,000) to give T. Here T is £6,000.
As (TA - LP) (£7,000) exceeds T (£6,000), the lessor is treated as making an additional profit of £1,000.
In summary the commercial position is:
|Rentals - years 1 - 5
|5 x 1,300 =
|Rentals - years 6 - 15
|10 x 1,900 =
|Sale proceeds
|Overall profit
And the overall tax position is:
|Rentals - years 1 - 5
|5 x 1,300 =
|Rentals - years 6 - 15
|10 x 1,900 =
|Deductions s.502E
|Deductions s.502F
|Additional profit s.502G
|Overall profit


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Broad, long-term objectives: The overexpression of epidermal growth factor receptor (EGFR) is observed in several types of solid tumors including non-small cell lung cancer and many carcinomas. We are using computational techniques to simulate binding of ligands known to interact with the ATP binding site on the kinase domain of EGFR in an effort to develop improved small molecules. Specifically, we are evaluating cancer causing EGFR mutations that include either a point mutation or a deletion on the activation loop that is positioned near the ATP binding site and the effect of these mutations on ligand binding. Other mutations, which arise as resistant mutations during treatment with compounds such as erlotinib and gefitinib will also be characterized. In order to develop small molecule inhibitors with specificity and high affinity for mutants, we will complete the following specific aims: (1) Characterize how mutations affect EGFR ligand binding using molecular dynamics followed by binding energy analysis. We will determine the behavior of mutations on ligand binding affinities, which amino acids in the binding pocket play an important role in the interaction between EGFR and each ligand, and the effect of each mutation on the active and inactive conformations of EGFR. (2) Design improved small molecule inhibitors based on computational analyses performed under aim #1 by ligand modification to improve affinity towards a specific mutation. We will use the scaffolds of the known inhibitors as well as that of the natural substrate to optimize binding affinity by performing functional r-group library searches. (3) Identify new lead structures using computational tools including virtual high throughput screening (docking) of ligand libraries. Again, we will optimize top scoring and populated structures using r-group library searches. The proposed aims will use the following computational methods: MD simulations, rigid and flexible docking using the anchor and grow algorithm;structural activity relationships and r-group libraries searches (rotamers). Methods for achieving the stated goals: The proposed aims use the following tools and software: AMBER, VMD, NAMD, MOE, Dock, BOSS, and BOMB. Relevance to Public health: Structure-based drug design is an important component of targeted drug development. The research proposed will characterize EGFR kinase domain mutations and their binding with known ligands using computer simulations. The use of the information generated will provide insight into the design of new ligands based on existing scaffolds and novel leads effective against EGFR mutants. Targeted design of new chemotherapeutic agents with high specificity and affinity will enable improved outcomes for patients with solid tumors that express mutant EGFR.
|Allen, William J; Fochtman, Brian C; Balius, Trent E et al. (2017) Customizable de novo design strategies for DOCK: Application to HIVgp41 and other therapeutic targets. J Comput Chem 38:2641-2663
|Allen, William J; Balius, Trent E; Mukherjee, Sudipto et al. (2015) DOCK 6: Impact of new features and current docking performance. J Comput Chem 36:1132-56
|Balius, Trent E; Allen, William J; Mukherjee, Sudipto et al. (2013) Grid-based molecular footprint comparison method for docking and de novo design: application to HIVgp41. J Comput Chem 34:1226-1240
|Brozell, Scott R; Mukherjee, Sudipto; Balius, Trent E et al. (2012) Evaluation of DOCK 6 as a pose generation and database enrichment tool. J Comput Aided Mol Des 26:749-73
|Balius, Trent E; Mukherjee, Sudipto; Rizzo, Robert C (2011) Implementation and evaluation of a docking-rescoring method using molecular footprint comparisons. J Comput Chem 32:2273-89
|Mukherjee, Sudipto; Balius, Trent E; Rizzo, Robert C (2010) Docking validation resources: protein family and ligand flexibility experiments. J Chem Inf Model 50:1986-2000
|McGillick, Brian E; Balius, Trent E; Mukherjee, Sudipto et al. (2010) Origins of resistance to the HIVgp41 viral entry inhibitor T20. Biochemistry 49:3575-92
|Balius, Trent E; Rizzo, Robert C (2009) Quantitative prediction of fold resistance for inhibitors of EGFR. Biochemistry 48:8435-48