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By Barry Lake, CEO & Chairman of Devana Solutions LLC
February 8th, 2017
Since I last wrote about this topic just a couple of weeks ago, President Trump has met with Pharma at a meeting at the White House to personally share his view that drug prices are too high.
Legislators are following in the President's footsteps by looking at new laws that will force prices down.
One of the legislative solutions being pursued by Senator John McCain among others is allowing prescription drugs to be imported from Canada.
And, as I observed in a previous blog, this is one issue that the national media is firmly on the side of the new Administration.
Quite understandably, the industry's response focuses on safety. The FDA has rigorous requirements before a drug enters the market in the US and no-one can guarantee such safety standards about drugs entering the country from elsewhere.
Safety is the industry's key issue. But that does not mean there is nothing else to be done.
This is a great time for the industry to be on the front foot and show that it is serious about the issue and will do anything within its power to lower prices.
And there are steps to be taken that will not compromise safety.
We all know that a huge part of drug costs is in the expense and the length of time it takes to develop and test new compounds.
There is a way for Pharma to safely reduce the cycle times of drug trials.
We at Devana estimate that 50c in every $ spent by a sponsor to develop a new drug ultimately goes to clinical trial sites.
Every week, we have conversations with many of the 6000 trial sites in the US that underscore to us how ready the sites are to embrace new disciplines and to bring data to CROs and Sponsors that will help 'good' trial sites be more easily identified.
More data, more evidence of which sites do a great job will reduce the huge sums of money wasted on sites which, for instance, enroll few, if any, patients into a trial.
Yes, we have a self-interest at Devana. We have solutions which help trial sites be transparent and accountable about performance and lead to improved, healthy collaboration with CROs and Sponsors.
But at this point it seems it is everyone's interest to take this seriously.
The new Administration certainly is taking the matter very seriously.
Devana Solutions® is a SaaS provider driven by a core belief that data transparency and data analytics technology to aid in selection of the top-performing Research Sites to align with pharmaceutical sponsors and CROs is key to reducing drug costs and curing disease. Devana Solutions® IGNITE FOR SITES cloud-based technology adds value to top Research Sites by centralizing study leads and contacts, automating pipeline administration and study document tracking to cut management time in half while proprietary algorithms simultaneously track site timing and performance metrics from study lead through trial completion. With a couple of mouse clicks, these metrics can be standardized into robust reports for drug sponsors and CROs to validate the sites' capabilities. Devana Solutions® MATCH PERFORMANCE reduces site selection risk for sponsors and CROs by providing dashboard and report capabilities not limited simply to a site's historical trials; but, real-time site performance & timing metrics on currently running trials, improving trial feasibility and performance while reducing clinical trial cycle time and costs. Devana Solutions® technology is leading a transformation of the clinical trials industry and each investigative site's "Devana Score" will become the "S&P Global Ratings"-equivalent for the clinical trials industry against which clinical trial performance by sites is measured. To learn more visit https://devanasolutions.com.

subset: commoncrawl


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Apple has been fined $368 million after their video calling feature, FaceTime, was found to infringe on patents owned by a company called VirnetX, a company that provides solutions for secure internet communications. A US court ruled that Apple's FaceTime product infringes on four patents by VirnetX. One of the patents at issue involved the ability to establish a secure communication link. Apple apparently has no option for appeal in this matter. VirnetX has also brought suit against a number of other larger companies over its patent portfolio. Natash Lomas of Techcrunch reports notes:
The BBC reports that the damages award is around half the amount VirnetX had originally sought. It also notes that VirnetX has previously secured a $200m settlement from Microsoft over similar claims.
The company, which has a patent portfolio of 20 U.S. and 26 international patents, has also brought cases against Cisco, Avaya and Siemens for allegedly infringing the same patents.
This is another in a recent string of legal defeats for Apple. Last week Apple was forced to amend a statement that had been ordered by a UK court that aknowledged that Samsung did not copy the iPad. A US judge also recently dismissed Apple's case against Motorola Mobility.
The VirnetX case might also shed some light on why FaceTime isn't open. When introduced in 2010, it was said that FaceTime would become an open standard. Many have speculated as to why that was. It may be that Apple found that they could not legally open FaceTime when some of the technology behind it was not industry-standard and under someone else's patents. While it seemed a longshot in the first place, with the VirnetX victory, the hope of an open FaceTime, appears to be gone.
Source: Techcrunch


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I just wanted to share with you the first of hopefully several new collections for this Fall. I just completed my wholesale catalog and sent it to the few retailers who had inquired about orders. If you are a retailer interested in carrying this line or other MODKID designs, please contact me via email at email@example.com for a wholesale catalog.
And here are a few shots taken right out of the catalog. The collection has 7 mix and match pieces: a jumper/dress, a 3-tier twirl skirt, a pair of corduroy flare pants, a pair of denim ruffle pants, a denim peasant shirt, a knit skirted top and a headband with detachable flower. There are 3 different styles of babywale corduroys used alongside some super soft denims and cozy knits. This collection is comfortable, fun, funky and wearable. It is easy to care for and will be perfect for Back To School and all Fall/Winter events.
For wholesale inquiries, please email Patty at firstname.lastname@example.com.
18 comments:
Goodness Gracious Mz Patty! What an awesome job you have done with your fall line. I already see at least one set that I will HAVE to have :) Job extremely well done!!ReplyDelete
Thank you so much, ladies! I am very excited about this one... and my next collection will be ready to debut soon! I'll keep you posted. :)ReplyDelete
Wow that looks fantastic!ReplyDelete
I'll take one of everything for my imaginary daughter!! Love it!ReplyDelete
Ok, I have been "stalking" your blog for awhile but I just had to come out of hiding and tell you that I remeber the very first set you listed and I have been in love every since! I love that your outfits are "wearable" as well as adorable! Thanks for sharing!!ReplyDelete
- Anonymous12:44 PM
It looks AMAZING, Patty! :) congratulations - what a fabulous job!ReplyDelete
PS: I have the same shoes as Miss Sophia - LOL!
Thanks again, ladies! So sweet!ReplyDelete
Simply Sophia (sorry, hun, I don't know your name), how nice of you to come out of lurking and leave such a wonderful comment. Hope to see more of you! :)
Sarah, LOL at the same shoes! I was seriously considering getting some for myself when I bought these for Miss Sophia, but my budget was limited at the time. They are so cool! :)
Looks great, Patty!ReplyDelete
You are amazing. The collection looks beautiful and the catalog layout is fantastic too :) Hugs, Eva
Wow, wow, wow Patty! I definitely love the outfit on Sydney in the last pic...too cute!ReplyDelete
Oops...I posted before I finished my thought. :) I love the photos too...is that at a local park or something? The layout is awesome!ReplyDelete
Thank you so much! :)ReplyDelete
Amber, yes, those were shot at a local park that has this beautiful fountain and also a kid water fountain area where the kids can splash around... that was their reward for the awesome modeling! They stripped out of the clothes and into their bathing suits for an afternoon of running & splashing! They had a blast!!! :)
Wow Patty, I love this collection. So can we as readers order these sets, or are they wholesale only?ReplyDelete
Thanks, Michelle! Nice to "see" you again. ;) Well, shortly I will be sharing a short list of retailers that will be carrying "Autumn Blooms" this Fall, but if any of my readers are interested in any specific pieces, they can contact me too. :)ReplyDelete


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24 November 2016
By Mark Elliot
By Mark Elliot
Philippine Airlines has chosen to adopt Sabre's AirVision Commercial Analytics solution in order to improve its revenue-generating capabilities.
This new technology brings commercial data from several different departments into one place, in real time, easing the process of analysis and enabling improved decision-making.
It will also allow PAL to optimise revenue per passenger instead of the historically used revenue per seat model, and can even measure the impact of passenger behaviour.
"Sabre's Commercial Analytics will allow Philippine Airlines to make more actionable decisions," explained Dasha Kuksenko, Sabre's vice president & regional general manager of airline solutions for Asia Pacific. "This solution also enables the airline to maximise revenue, improve efficiency and productivity, while driving a competitive advantage.
"By using Commercial Analytics, the Philippines flag carrier will have the ability to look at customer segments instead of simply fare purchases. This gives the airline more insights into their customers' purchase propensities and the ability to recommend actions to best suit the business needs of the airline," she added.
Dina May F. Flores, PAL's vice president of revenue management, said that the new technology would "help us better understand our customers' buying behaviour".
Sabre and PAL are both currently at Association of Asia Pacific Airlines' (AAPA) Assembly of Presidents in Manila.


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I modified the mybook in a number of ways:
Making mybook cool and quiet
And probably a few other ways too! Basically i thin I got carried away as the mybook is my first voyage into the wonderful world of Linux. I can now only access the mybook through ssh and not via samba share or via ftp as the mybook is not recognising passwords for either the samba or the ftp. The samba share and the ftp are running I just am unable to work out how to change passowrds (web interface doesnt work).
Any help on resetting the samba share password or the ftp password would be greatly appreciated.
However I now think I would like to return to a virgin install and start again, however I have 400gb of movies I dont want to loose, is this possible?


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The only sparks that flew in the 4th District City Council race yesterday came from two incumbents over accusations that one of them abandoned a team campaign concept and "single-shot" at the polls.
Council members Lawrence A. Bell and Sheila Dixon got in a heated argument about 3 p.m. yesterday at the polling place at DTC Eutaw Marshburn Elementary School in West Baltimore, witnesses said.
Bell declined to comment, saying only that he is happy the incumbents won.
Dixon downplayed the argument, but said she was surprised to find Bell handing out his own literature.
"We had agreed to a certain ticket," she said. "He [Bell] backed out of it."


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Our Menu
Our breakfast menu includes pastries, breakfast sandwiches & cooked breakfasts all made with quality ingredients and free range eggs.
For lunch we offer our regular favourites and a specials menu which changes fortnightly. Our Winter warming menu includes the Holy Cow homemade burger, braised beef and veg pie, vegetable curry, chilli wraps and the always popular pulled pork with Hoisin sauce on a toasted bun. To accompany the above, or simply to eat on their own, we have a range of nutritious, tasty salads. Both our lunch and breakfast menu has vegetarian and gluten free options available.
There are now eight types of coffee and a variety of teas and if you fancy something sweet the selection of homemade cakes provided by our farmhouse kitchen or the famously rich and tasty The Pudding Kitchen should do the trick!
Saturdays & Sundays are breakfast only but with a menu even more delicious!


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Monday, March 12: Meatball sub, mozzarella cheese, whole wheat sub roll, tossed salad, apple
Tuesday, March 13: Baked chicken, whole wheat roll, mashed potatoes, gravy, coleslaw, sliced oranges
Wednesday, March 14: Stuffed peppers, whole wheat roll, rice pilaf, mixed vegetables, mixed fruit
Thursday, March 15: Corned beef, cornbread, boiled potatoes, cabbage and carrots, bread pudding
Friday, March 16: Tuna melt, American cheese, whole wheat bread, potato salad, pickles, vanilla pudding
The Plymouth Council on Aging Senior Center is located at 44 Nook Road, Plymouth. Coffee, tea, milk, margarine served with all meals. Menu subject to change without notice. Make reservations one week in advance. Must be 60 or older. The cost is $3 per person per meal. Call 508-830-4230 to make a reservation.
Monday, March 12: American chop suey, green beans, parmesan cheese, rye bread, fresh apple
Tuesday, March 13: Chicken scallopini, herbed brown rice, brussel sprouts, garlic roll, vanilla pudding, sugar free oatmeal cookie
Wednesday, March 14: Whole grain breaded pollock, whipped sweet potatoes, garden vegetable blend, tartar sauce, whole wheat hamburger roll, banana
Thursday, March 15: Corned beef, boiled red bliss potatoes, cabbage, carrots, whole wheat dinner roll, shamrock cupcake, Lorna Doones
Friday, March 16: Egg frittata, pancakes, spinach with red peppers, sugar free syrup, wheat bread, fresh orange
Menu subject to change without notice. Suggested donation: $2.50. Meals on Wheels are delivered year-round, Monday through Friday under authorization of Old Colony Elder Services (OCES) for elders who satisfy the criteria. For information or cancellations of home delivered meals, call 508-584-1561. Cancellations should be made no later than 10:30 a.m. the day before delivery.


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Yesterday, Americans were given a perfect example why an unhinged child should not be elected to be the President of the United States.
Speaking at a joint press conference with Australian Prime Minister Malcolm Turnbull, Donald Trump went on an unhinged rant and made a threat that should terrify not only the entire country, but the world.
When Trump was asked what he would do if his proposed North Korean sanctions didn't work, his response made jaws drop. There was absolutely no reasoning or logic from the president, just that trigger-happy, egotistical impulse that makes him so terrifying. Unable to formulate a diplomatic answer, Trump resorted to being his revolting self and threatened "the world." He said:
We'll have to see. If the sanctions don't work, we'll have to go Phase Two. Phase Two may be a very rough thing, may be very, very unfortunate for the world."
WTF?! Does Trump even know what he just said? Once again, Trump is suggesting that he's considering a military strike on a nation that he has previously threatened with nuclear war.
This is unhinged Trump at his worst. As he's just had a disastrous week of more bad news on his Russia investigation and is being pummeled for his horrific response to the school shooting in Florida, he's clearly falling apart. And we all know that when Trump starts feeling scared and backed into a corner, he starts lashing out and acting even more erratically. That's why this statement is terrifying — and there's probably more to come.
Trump still doesn't see that his threats are only going to make things worse for him — and he's going to drag the whole country into his mess. You can watch Trump make these alarming comments below:
Trump: "If the sanctions (on North Korea) don't work, we'll have to go Phase 2. Phase 2 may be a very rough thing, may be very, very unfortunate for the world" https://t.co/hGaihb7YLa
— CNN Politics (@CNNPolitics) February 23, 2018
Featured image via Ralph Freso/Getty Images


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How to Bring in The Business in 2013 Pt. 5 of 5
Build Your Business With Packaging Products
If you've ever watched late night infomercials on TV then you are very familiar with packaging products. Buy five Ginsu Knives for $39.95 and get a bunch of other knives and kitchen gadgets free. So what's the secret to this type of merchandising? In simple terms the "snake oil, door-to-door salesman" went electronic. The carnival barker of old morphed into the new "ShamWow" 21st century sales pitch.
How Packaging Works on Late Night TV
Most main street businesses try to earn your trust to cultivate repeat business. Late night hucksters could care less if you never come back and don't have the time to earn your trust. Their motivation is to play on your greed. Establish a need that you didn't even know you had that would feel so good if you only had the product. And then, to drive your level of greed even higher, offer more than you were expecting for the same price you convinced yourself was a value. Your credit card is out, phone to your ear and you've helped keep UPS in business one more day.
How to Make Packaging Work on Main Street
When you run a newspaper, magazine or radio ad you are doing a variation of the late night infomercial. You are exposing a product to a large group of people hoping that enough of them will be willing to let that product solve their problem in exchange for a buck or two.
To motivate you, common phrases are used. "Hurry! Supplies Are Limited." Of the following three phrases, "50% Off," "Half Off," or "Buy One; Get One Free," which one do you think would be the most effective? Study after study shows that, "Buy One; Get One Free" will produce higher sales.
How To Use Packaging to Beat Your Competition
I'm guessing that this past Christmas you did some comparison-shopping. You found an item you liked and shopped for the lowest price from a variety of retailers offering that item. This is usually a problem for a "mom and pop" store competing against big name box stores. They simply don't have the buying power to compete for the same products. So the consumer ends up going to the location with the lowest price.
Suppose there was a way to show your customer a better way to buy? There is — packaging products together. An XYZ Model 123 digital camera regularly sells for $99 but the big box store has it on sale for $79. You need to sell it at $109 to make a profit on the sale.
What would be an incentive for a customer to still pay $99 or more for the same camera? Using the Ginsu Knives business model you would first establish that the camera is indeed worth $99 and $20 off would be a deal by itself. But what if you got a lot of value for another $30?
Suppose they could get a $150 dollar value for $109? Your suppliers might give you a deal on a free case, extra video card, extended warranty etc. for each camera you buy. The markup on accessories is usually higher than the camera itself so it would be easy to show the savings.
Now the customer has some thinking to do. Do I want to pay a little more and get the free stuff or do I want to get the low priced camera knowing that I'll probably eventually buy the free stuff and pay more than the asking price to get it. This is where greed should set in. Even though I'm going to pay more than I thought I'm getting more for each dollar I spend.
Some Final Thoughts
Successful packaging requires thought and planning and a very detailed knowledge of your expenses and sales force. There is another danger to be aware of. If you do sales too often your customers will quickly learn that 20-30-50% is now your normal price. They will simply sit on their hands and wait for your next sale and suddenly you are buying the business with your profit.
Suppose you have a product, and you make $100 in profit, if you sell ten of them. If you operate on a 30% margin and mark that product down 20% you are going to have to sell twice as many to make that same $100 profit.
Retail sales are far from an easy business. Competition, consumer perception, labor, suppliers, expenses, have to all work together for a successful business to survive. Start slow and learn the art of packaging products. Your customers will like it and so will your accountant.
How to Bring in the Business in 2013, Part 1 of 5
How to Bring in the Business in 2013 Part 2 of 5
How to Bring in the Business in 2013 Part 3 of 5
How to Bring in the Business in 2013 Part 4 of 5


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PUDSEY ST LAWRENCE captain James Smith insists that the club's ground-breaking trip to Abu Dhabi is no jolly up.
The Bradford League champions do battle with Yorkshire Premier League South winners Wakefield Thornes in the Yorkshire Premier League final at the Zayed Stadium in a day-night affair on October 27 – with players heading out to the Gulf this weekend.
It promises to be the cricketing experience of a lifetime for both sides, with the game and whole occasion attracting the attention of everyone connected with both clubs, with West Indies playing Pakistan at the stadium prior to St Lawrence's and Thornes' own blue-riband appointment.
But for Saints skipper Smith, with his captain's hat firmly on, it about business – and not just sun, sea and more sun.
Smith, whose side qualified for the final with a last-four win over Great Ayton at Headingley in September, said: "It is brilliant for the club and did not get real until last Friday when I got my travel insurance.
"It is great for the club and the spectators who are going and we have got around 20 people who are going and a nice little following.
"A lot of the people who are travelling out there are family members of the pllayers and the players are saying what is flexible on the itinerary. It is about actually reminding the players that we are actually there to play some cricket and it has been quite funny!
"We have earned this and there is no point going out there and messing about.
"We have to embrace it and take it for what it is – hopefully being crowned as the best Premier League team in Yorkshire."
On the itinerary, he added: "We fly on Saturday and then practice on the Sunday and Monday and we play a warm-up on the Tuesday with a day's rest on Wednesday unwinding before the big day on Thursday.
"And looking at the pitch, it looks absolutely sensational.
"It is an exciting time, playing under the lights overseas with a pink ball. It will be amazing.
"While some want to appreciate the culture, we are there to play a game of cricket and win on Thursday and get other things out of their heads, although we will stick to the itinerary as close as possible."
St Lawrence face a Thornes side who have themselves enjoyed an outstanding campaign.
The Wakefield outfit beat Yorkshire Premier League North winners Harrogate in their semi-final at Scarborough.
Smith has been impressed by their feats, and says St Lawrence will be treating them with plenty of respect.
He added: "They're obviously a decent team who won their league pretty convincingly.
"As with every opposition, we must give them the respect that they deserve. We know Faisal Irfan from his days with Cleckheaton and Pudsey, and Mahmood Rasool played at Lightcliffe, and they are their two opening bowlers.
"And Chris Marsden is quite familiar with a few of their team as he is from Wakefield way."
He added: "We know enough about them.
"They are a good team and we have got to perform."


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This strawberry almond milk shake is my new solution whenever I crave something sweet & creamy. It is guilt-free, refreshing, and perfect for all the warm summer nights we've been having here of late – a great healthy alternative to heavy, sugar-laden ice cream.
It is super simple to make and very easy on the digestive system as it is free of dairy and refined sugars. As outlined in the recipe, it is sweetened with strawberries and a little agave syrup (or your sweetener of choice), but you can substitute the strawberries for any other fruit if you prefer. It is also great for kids, who likely will think it is a milkshake, and a good source of calcium, vitamin C & antioxidants!
Click here for how to make your own almond milk
|Almond Milk Strawberry Slushie
- ½ cup strawberries (fresh or frozen)
- 1 cup almond milk
- 1 tbsp agave syrup (honey, maple syrup & stevia can be used instead)
- 1 tsp vanilla extract
- 5-6 ice cubes
- Combine all the ingredients in a high-speed blender until a thick slush-texture is achieved
- Pour into a chilled or cool glass and serve immediately.


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It was a bright and sunny day which allowed us to enjoy each other's company and eat and drink in the garden :-). Maybe we spoiled her rotten but we sooo enjoyed it! ;-) A few weeks/months before we went to EuroDisney for three days, she got a new bicycle (little sis needed a bigger size so we asked if she wanted her older sis' bike which was the case so ... our "communion girl" got a new bike) and a Samsung Galaxy slate (or is it tablet ?) because she did well in school and can use this for practice and games :-).
The garden party :-)
Appetizers and (cold) buffet - look at that little hand (my youngest DD) snatching a small bread
Ice-cream cake as dessert and the candy cake she got from her uncle and aunt
Something which was very funy were two performances of the teachers. I can't show you pictures because I want to protect everyones privacy ;-)
On Sunday we paid a visit to the zoo which gets better and more beautifull each year (lots of investements going on).
The zoo's shuttlebus with it's new attraction "Walk between the Penguins" (Humboldt)
"We're going over there" ... let's visit the Koala's!
Did you notice the grey heron in the backlot of the picture?
Looking at the right - yes ... we're in the "Australia" section of the park :-)
Me thinking "please don't fall! I don't have dry clothes with me!" ;-)
Another beautifull view - the park is full with spots like this!
The new star attractions - Humboldt Pinguins and their quarters
Something new for the kids - a stone fortress!
We're back in America - look at those teepee (the bizon are at the right)
While our kids were playing here ...
... we were sitting just besides this ... enjoying a drink and the sound of water ...
... and looking at these guys ;-) The park has a lot of nests with white storks which return each year.
I hope you enjoyed your virtual visit! Off for a four-day long weekend - tomorrow is a Bank holiday and we don't have to work on Friday :-)! Shall I x-stitch, quilt or knit ... or both three?!


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History of Calgary – Then & Now – 1885 and 1912
1885 – Population of 500
2012 – Population of 1.1 million
2016 – Population of 1.3 million
In 1885
In February of 1885, Jack Ingram was officially named as the first police chief of Calgary.
His experience as a former police chief of Western Canada, out of of Winnipeg at the time, helped supplement him into the new job. He was initially given two assistant constables to help him with his duties.
The first city police station was based in the back of a pool hall located on 8th Avenue SW (Stephen Avenue).
Funny thing is that the station had to wait several months before the facility even had a phone installed. At the time the city was home to a bit over 500 people.
In 1886
In November of 1886, a fire rampaged through the city burning down its wooden structures with ease.
The fire either directly or indirectly caused the destruction of 14 buildings in total and financial losses were estimated at approximately $100,000. Fortunately for Calgary's residents, no one was injured or killed during the incident.
City politicians responded by creating a law stipulating that downtown buildings needed to be constructed out of Paskapoo Sandstone, a fire retardant building material made into bricks.
Today you will still see several buildings made out of this sandstone material in and around the downtown area.
Calgary 1912 – Eighth Avenue was the commercial heart of the city, with original sandstone buildings containing retail, serviced by streetcars
Calgary 2012 – Today Stephen Avenue is one of only three National Historic Districts of Canada, preserving an important piece of Calgary's history
In 1912
In 1912, an American named Guy Weadick partnered with a man named H.C. McMullen and rallied enough financial support from local businessman to begin a "wild wild west" outdoor show.
The City of Calgary began constructing an outdoor rodeo grounds and over 100,000 people attended the rodeo over a 6 day time frame to be entertained by the cowboys who had come from all over North America. At the time prizes for the contestants totalled over $200,000!
This was the beginning of the Calgary Stampede, the greatest outdoor show on Earth and as you know, this year in 2012 it is its 100th anniversary!
Quite a few different Calgary Landmarks are also connected with the year 1912 in some way or another.
Some built that year include the first Calgary Public Library, the Grand Theatre and the Lougheed Building, while the establishment of the University of Calgary also occurred.
I Love Calgary
Calgary is such an awesome city to live in! Don't miss 20 Reasons Why to love Calgary and join us today at Calgaryism on Facebook, Twitter and Instagram for more of everything to do with this wonderful city I love today!


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Tree Service, Tree Trimming or Tree Removal
Happy Tree is a fully certified and insured tree service company in Austin, Texas and surrounding areas like Circle C, Barton Creek, Oak Hill and Sunset Valley. Happy Tree Service provides the following arborist services: tree removal service, tree trimming, tree pruning, tree cutting, tree spraying, tree fertilization, dead tree removal, oak & cedar tree removal, stump grinding, tree planting, arborist services and tree care services with affordable prices. For premium and local tree guys that you can afford, call today 24, 7 live answers!
Sunset Valley
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Happy Tree of Austin


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Lamb"kill` (?), n. (Bot.)
A small American ericaceous shrub (Kalmia angustifolia); -- called also calfkill, sheepkill, sheep laurel, etc. It is supposed to poison sheep and other animals that eat it at times when the snow is deep and they cannot find other food.
© Webster 1913
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Critical Linking: November 27th, 2013
In 1936 — perhaps the darkest year of his life — F. Scott Fitzgerald was convalescing in a hotel in Asheville, North Carolina, when he offered his nurse a list of 22 books he thought were essential reading. The list, above, is written in the nurse's hand.
Not on the list? Anything by Ernest Hemingway.
The British marketing research agency Voxburner recently surveyed more than 1,400 people, ages 16 to 24, about their media-consumption habits. The survey found that 62% of the respondents said they prefer printed books to e-books.
Interesting result. Though, to prefer something doesn't necessarily mean you will use it more often. For example, I "prefer" hand-written letters, but email is cheaper, faster, and easier.
Barnes & Noble has turned a profit in its second quarter of trading, but sales in its Nook business have dropped by 32%. The US bookseller reported second quarter earnings for the three months to 26th October were up 13.7% to $76m (before EBITDA), in comparison to the same period a year ago. The profits were achieved despite falling sales, as second quarter consolidated revenues decreased 8.0%, to $1.7bn, compared to a year earlier.
So sales down, but profit up. I wonder if B&N's closing of underperforming stores over the last year might be one of the reasons for this. Better to take in less money and be profitable than to see revenue go up and lose money. Those Nook numbers, on the other hand….
But in 2010, the American Booksellers Association saw its first increase in membership in many years, and by 2013 the sector had recovered enough that independent bookstores are once again seen as critical to the success of the book industry. For their role in leading the resurgence of independent bookselling, ABA CEO Oren Teicher and the ABA board have been chosen as PW's Person of the Year.
A good sentiment, but I wonder if the commendation shouldn't have been giving to "Jane and Joe Bookseller"–you know, the people on the floors of independent bookstores that make them what they are.
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To keep up with Book Riot on a daily basis, follow us on Twitter, like us on Facebook, , and subscribe to the Book Riot podcast in iTunes or via RSS. So much bookish goodness–all day, every day.


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out of 100
Metascore®Mixed or average reviews Based on a weighted average of all critic review scores.
A sample of reviews from critics across the country.
More than ever, Johnny Knoxville and his boys belong to a very elite club of idiocy. They martyr themselves for our diversion, driven at every moment to ask: Are you not entertained?
Read full review
While Jackass 3D can never be accused of stinting on its spring-loaded arsenal of projectile bodily fluids, neither does it approach that sublime, laugh-until-it-hurts level of gross-out nirvana that made the first two installments so darned irresistible.
It's reductive, insanely violent slapstick, but that's the phenomenon in a nutshell.
See all Jackass 3 movie reviews at Metacritic.com
Movies.com Critic
The most poop-tastic film of the year.
Read full review | Comments (7)
Body fluids in 3-D. You've been warned.
Read full review |
Comments (18)
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
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FAKRO FTT/U U8 Thermo 09 White PU Quadruple Glazed High Pivot Roof Window 94x140cm1 Customer Reviews
£1,229.00£1,474.80 inc. VAT
Multibuy discount
- 1+ £1,229.00
- 2+ £1,193.00
- 5+ £1,160.00
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text:
-Senator Brownback (R-KA)
Why he has not done so is a matter of some speculation, although I suspect it has to do with his strong understanding of the separation of powers in the US Government. Each branch of the US Government is equally powerful and sovereign in their area (legislation in congress, for example), and I believe President Bush thinks that a veto should only be used in the most egregious examples of moral or legal corruption.
With the recent Stem Cell research bill passing both the Senate and the House of Representatives, the bill should reach President Bush today. He has promised to veto that bill:
"I made [it] very clear to the Congress that the use of federal money, taxpayers' money, to promote science which destroys life in order to save life, I'm against that," Bush told reporters. "Therefore if the bill does that, I will veto it."What is this bill that has the President finally reaching for his dusty, cobwebbed Veto stamp? It is a bill that issues federal funding for stem cell research. The federal government already funds stem cell research, but since 2001 has not funded any research using embryonic stem cells. Congress is offering a bill that extends funding for that sort as well.
Some Congressmen are pleading with the President to sign this bill and put it into law - likely aware that they have not the votes to overrule his veto at this point.
"Please, Mr. President, don't veto this bill," said Sen. Gordon Smith, R-Ore., noting that his family has a history of Parkinson's disease. "Such a veto, I fear, may only throw out hope, healing and human life along with the unused embryos."
Sen. Ron Wyden, D-Ore., said scientists think stem cells offer the possibility to treat myriad diseases and disabilities, such as Parkinson's and Alzheimer's diseases, strokes, diabetes, spinal-cord injuries and osteoarthritis.
"I see no reason why embryonic stem-cell research should be treated any differently than other research," Wyden said. "Without expanding the research beyond the bounds of current policy, people will never know what might have been."
Scientists hope and postulate that such research could cure diseases such as Parkinson's by regrowing nerve cells, regenerate lost fingers or even limbs, and even stop or reverse ageing. At present, there have been successful treatments using stem cells, such as a treatment that recovers hearing loss, generates cells for the production of insulin for diabetics, reverses kidney failure, and reversal of crippling paralysis, various neural diseases such as polyneuropathy, lupus, and multiple sclerosis all show improvement. So why veto the bill?
He described a conversation he had with his conservative colleague Sen. Sam Brownback, R-Kan.
"He said his concern was the question of when life began," Specter said Tuesday. "I told him my concern was when life ended."
It is the depth of horror and the subject of many sci fi stories to kill the living in order to make rich adults and elderly more comfortable and live longer. The term I use is "necromancy."
2) Because all those successful treatments from stem cell research I listed have been from adult stem cells. These are very plentiful and available from such odd sources as the ears and nose of donors and especially the umbilical cord. Given that thousands of babies are born each day in the USA alone, this is a very plentiful and cheap source of stem cells. Such research does not require the death of anyone and has been successful and very promising.
4) Because embryonic stem cell research has been not only a failure thus far in almost all cases, but actually damaging and destructive to the people it has been tried on. For example, while researchers have successfully produced insulin-secreting cells with embryonic stem cell research, the result is not transplantable because they don't have a tissue match for the patient. Further, the embryonic results often cause tumors and cancer in the patients, and in at least once case caused uncontrollable seizures. The cells grow out of control and in areas the research does not intend. No viable therapy has been generated from embryonic stem cell research. Dozens have been generated by adult stem cell research. Embryonic stem cell research characteristically results in the growth of tumors and other unpleasant side effects.
5) Because Japanese researchers have discovered that adult stem cells can be as effective as embryonic stem cells, a story that skated past the press and most people's awareness. These doctors used mouse stem cells (from the tip of their tail):
The ES [Embryonic Stem cell] -like cells the group produced with the four introduced genes seemed to have almost all the key properties of ES cells derived from embryos. They formed several kinds of tissue in the culture dish and produced tumors called teratomas when they were injected under the skin of immune-compromised mice--both classic characteristics of ES cells.Researchers at Tufts University came to the same conclusion, saying that they believe they have discovered an adult stem cell that has the same potential as embryonic stem cells. The head of the research team said "I think embryonic stem cells are going to fade in the rearview mirror of adult stem cells." In any case, stem cells from the placenta - again present in every birth in the world - are also considered adequate replacement for embryonic stem cells.
6) Because the federal government has no constitutional authority or power to fund any kind of stem cell research, no matter how nice it might be. The US Constitution is very clear on what the government may and may not tax people for and spend money on, and the 10th amendment makes it very clear that anything not listed is forbidden for the government to engage in. Funding medical research is not one of those things.
7) Because even were it constitutional and not either a failure or a ghastly moral violation, embryonic stem cell research is being done by thousands of companies worldwide without the requirement of the US government's - your - money. The common complaint about pharmaceutical corporations is that they are grossly wealthy and overcharge for their product, that they are greedy and price-gouging. If they have these vast sums of money, why do they need your tax dollars to do the research? If companies and research labs around the world are already doing this work why do they need your tax dollars to do it?
It's wrong, it's a failure, its unnecessary, and yet some persist in strident, often insulting calls for this funding. So why on earth would anyone anywhere want this? Because embryonic stem cells show incredible powers of healing and growth. They are what scientists believe allow a newborn baby to heal rapidly from harm and even regrow a joint lost from a finger or toe in some cases. They believe this is what makes a fertilized egg grow into a newborn baby in a short 9 months. So they want to tap into this immense growth and healing power to see what it can result in for adult humans.
The original claim was the Embryonic Stem Cells lasted forever in storage while adult stem cells did not. This has been demonstrated to be inaccurate (ES don't last forever, according to this report), and even were this true, the source of embryonic stem cells is dwarfed by several magnitudes by the sources of adult stem cells. Researchers have ideas and dreams and need money to test these theories out. They can get money from private research, but the government is an almost endless source, and they want at that vast sea of taxpayer dollars. So they push for their personal agenda.
And I am fine with that, I respect the desire. Just don't do it at the expense of helpless, innocent human life. Murdering babies to make adults feel better or live longer is one of the most evil things I can imagine.
The worst part is the gross and often willful ignorance in regard to this debate. Glenn Reynolds, the Instapundit, constantly acts as if not only has President Bush banned stem cell research but that embryonic stem cell research is the only kind that exists. You will read again and again that the President "banned stem cell research" from people who know better but will say that because it sounds better and makes him look like an anti-science clod. You will see people claim that the president banned embryonic stem cell research, when he did no such thing, he simply banned federal funding for such research. Even though President Bush no doubt would like to ban all such research he does not have that power.
That's why I wrote this long entry this morning. Because of the misinformation, ignorance, and deliberate lying that goes on about this topic.
Dr. Michael Gazzaniga in the New York Times called an early cloned embryo just a "hunk of cells," and said that human dignity resides in a "lifetime of experiences and discovery." Thus, according to this fellow, the older you are, the more worth you have - and an unborn or just born human is nearly or completely worthless? This is the kind of "reasoning" that led Dr Josef Mengele to his research which while it revealed a great deal of useful scientific information was judged so ghastly and immoral that it was sealed and never used.
Most of the people backing embryonic stem cell research and its federal funding are pro-abortion, they consider an unborn baby at most subhuman and unworthy of the considerations we give fully born humans. For them, a magical transformation occurs when the baby exits the mother.
Jacki Rabon from a wheelchair in the US Senate gave a speech to the assembled body about adult stem cell research that is helping her and has been so effective. In this speech she talked about the dehumanizing of someone for the convenience or advantage of another:
At one point in time, we have all started out as an embryo. Whether you are Sam Brownback, the Presiding Officer, or anybody in this room, we all started out being a human embryo. We didn't start another way. If you destroy us at the earliest stage, you never end up with us at this stage. That is a basic fundamental of the argument.I agree with Senator Brownback. Let's focus on what does work, and has no ethical horrors attached. How could anyone in good conscience possibly argue with that?
It is an old, old, old debate for human societies. We have had this debate. Typically, in fighting around the world, people try to dehumanize the other side.
I remember watching a film on Rwanda, "Hotel Rwanda,'' about the Rwandan genocide. I was just in Rwanda last year and in the Holocaust Museum. The one side persecuting the other side, killing nearly 800,000 in 3 weeks, in the very typical fashion of human beings demonizing the other side and calling them less than human, they were subhuman--they were roaches is what they actually referred to them as.
*UPDATE: President Bush vetoed the bill. Now congress has to decide if in the coming months they want to try to overrule this veto.


text:
I got curious about this question when reading the comments Mathew Ingram's recent post on social networks and uptime. Mathew noted the curious case of Twitter, which is the social network "that everyone wants to use" despite it's near-legendary struggles with downtime last year. Another commenter asserted that Imeem was actually more popular than Twitter (really? hmmm, maybe that comment was planted by Imeem).
Anyhow, this got me thinking about ways of measuring popularity. I could have easily just looked up traffic stats for social networks on compete.com, but that's too straightforward.
Instead, I turned to my favorite quick-and-dirty buzz tracker – Neilsen's BlogPulse. After all, a reasonable way to measure something's popularity is to look at how much it's being talked about. Tracking blogosphere mentions of social networks also removes the bias inherent in tracking mentions on the social networks themselves.
So I punched a few keywords into BlogPulse. Here's their track of blogosphere mentions of Twitter, Facebook and MySpace over the last 2 months:
Facebook's recent spike no doubt due to the terms of service kerfuffle. Funny, the Facebook and Twitter lines seem to rise and fall in lockstep with each other — I guess there's a lot of posts out there comparing these two. (Like this one.) And it looks like people have pretty much stopped talking about MySpace in the last few weeks, despite healthy chatter before Xmas.
Here's another one, to test that assertion about Imeem in comparison with attention hogs Facebook and Twitter.
Ha ha, looks like almost nobody at all is talking about Imeem. I guess bloggers don't like music or something.


text:
Bailian Li
Senior Vice Provost for Global Engagement
Department of Forestry and Environmental Resources
Primrose Hall 106
Area(s) of Expertise
Forest Genetics, Tree Breeding
B.S. Beijing Forestry University (1982)
M.S. North Carolina State University (1985)
Ph.D. North Carolina State University (1989)
Research Interests
Forest genetics and breeding; Quantitative and population genetics; Breeding strategy development; Genetic data analysis and interpretation;
Genetic studies of tree physiology and molecular biology
Office of International Affairs
- In vitro tetraploid induction from leaf and petiole explants of hybrid sweetgum (Liquidambar styraciflua x Liquidambar formosana) (2017)
- Genetic variations and miRNA-target interactions contribute to natural phenotypic variations in Populus (2016)
- Association genetics and transcriptome analysis reveal a gibberellin-responsive pathway involved in regulating photosynthesis (2016)
- Genetic architecture of growth traits in Populus revealed by integrated quantitative trait locus (QTL) analysis and association studies (2016)
- Identification of additive, dominant, and epistatic variation conferred by key genes in cellulose biosynthesis pathway in Populus tomentosa (2015)
- Genome-wide transcriptional profiling reveals molecular signatures of secondary xylem differentiation in Populus tomentosa (2014)
- Megasporogenesis, megagametogenesis, and induction of 2n eggs with colchicine in poplar section Aigeiros (2014)
- Variation in growth, leaf, and wood property traits of Chinese white poplar (Populus tomentosa), a major industrial tree species in Northern China (2014)
- Identification of genes differentially expressed in shoot apical meristems and in mature xylem of Populus tomentosa (2014)
- Allelic variation in a cellulose synthase gene (PtoCesA4) associated with growth and wood properties in Populus tomentosa (2013)


text: Property ID : AlW-R-1661 Commercial for Rent AED 250,000.00 - Retail 1800.00 Sq Ft Bedrooms Bathrooms1 Print this page Multiple UnitsAvailable Big Retail Shops (Shell and Core) in Business Bay, Damac Maison Canal View For RentI haveretailsshops next to each other with highceiling in Canal Viewsand very good options as per clients requirements and suitable budget.Shell and Core Retails Shop Space1 Parking Space1800 Sq. Ft.Canal ViewUnfurnishedCity: DubaiCommunity: Business BayBuilding: Damac Maison Canal ViewsPrice:250,000 AED Per Year - 1 Cheque5% Commission5% DepositHURRY UP DO NOT MISS THE OPPORTUNITY! CALL US NOW!Contact Now: 0562130219Email: email@example.com: ALWAYS PROPERTYRERA ORN: 11751 Office Phone: +971 (0) 4 452 2267Office Fax: +971 (0) 4 431 3719Email: email@example.com: www.always-property.comFacilities: > 5 Mins from Dubai Mall> La Maison Restaurant> Outdoor Swimming Pool> Suana> Jaccuzy> Steam Room> Kids ClubMetro: Business Bay Metro StationAbout Property: DAMAC Maison exudes warmth and sophistication to a degree that will impress the worldliest of travellers. Be mesmerized by the astounding views of the Business Bay and Downtown Dubai from the aptly named Canal Views Dubai.Our Office Location: Office No: 506, Opal Tower, PO BOX 643788, Business Bay, Dubai, UAE. Office Timing: 9.00AM to 7.00PM (Sunday to Thursday) PROPERTY FEATURES: -Balcony -Basement parking -BBQ area -Broadband ready -Broadband ready -Built in wardrobes -Central air conditioning -Community View -Covered parking -Fully fitted kitchen -Fully furnished -Gymnasium -On low floor -Shared swimming pool -Steam room -View of gardens -View of parkland -View of sea/water -24 hours Maintenance -Bank/ATM Facility -Bus services -Business Center -Children's nursery -Children's play area -Cycling tracks -Metro station -Mosque -Public park -Public parking -Public transport -Restaurants -School -Shopping mall -Shops -Walking Trails Less More Additional Details Building: Damac Maison Canal Views Features Balcony Built in wardrobes Covered parking Property Map Share this Facebook Twitter Google Agent ALWAYS PROPERTY 01 Office : Mobile : 0562130219 Fax : Know More Contact Name Email Subject Message Find Your Property Property ID Property Location Any Dubai Abu Dhabi Ras Al Khaimah Sharjah Fujairah Ajman Umm al Quwain Al Ain Property Status Any Commercial for Rent Commercial for sale Residential for rent Residential for Sale Property Type Any Hotel Apartment Penthouse Duplex Land Residential Land Mixed Use Commercial Full Building Labour Camp Residential Building Townhouse Warehouse Apartment Retail Building Land Commercial Villa Loft Apartment Multiple Sale Units House Multiple Units Staff Accommodation Plot TownHouse Office Villa Industrial Min Beds 0 1 2 3 4 5 6 7 8 9 10 11 12 Any Min Baths 0 1 2 3 4 5 6 7 8 9 10 11 12 Min Price Any AED 1,000 AED 5,000 AED 10,000 AED 50,000 AED 100,000 AED 200,000 AED 300,000 AED 400,000 AED 500,000 AED 600,000 AED 700,000 AED 800,000 AED 900,000 AED 1,000,000 AED 1,500,000 AED 2,000,000 AED 2,500,000 AED 5,000,000 Max Price Any AED 1,000 AED 5,000 AED 10,000 AED 50,000 AED 100,000 AED 200,000 AED 300,000 AED 400,000 AED 500,000 AED 600,000 AED 700,000 AED 800,000 AED 900,000 AED 1,000,000 AED 1,500,000 AED 2,000,000 AED 2,500,000 AED 5,000,000 Min Area (Sq Ft) Max Area (Sq Ft) Special Offers


text:
Fano¸ is a tiny island with much to provide. Both the North Sea, beaches, national forest along with terrific experiences in the nature.
On Fano¸ you can, initially, locate peace as well as tranquility in an attractive setting. Our island, hence, has an extremely special relaxing setting that suit both households with youngsters, bonvivants and individuals who seek excellent encounters in the nature.
Factors associated to – Bed and Breakfast
Nonetheless, Fanoe is likewise for you which want an energetic getaway – hiking, cycling, kite-buggies, golf and also much more.Fanoe is numerous in culture with galleries and fine art museums along with the culture-historical towns Nordby and Sønderho.
UNESCO World Heritage
Fano¸ and also the Wadden Sea Nationalpark was selected Nature World Heritage ini 2014 by UNESCO.
Nature on Fano¸
The Wadden Sea as well as The North Sea – Fanø¸'s West Coast is one lengthy sandy beach. 15km coastline for bathing, sports, accumulating brownish-yellow, seals as well as a lot more. The eastern coastline has tidal flats with birds, oysters and also tide.
Fano¸ supplies fantastic nature experiences all the time. The coastlines as well as the coastline are the main nature magnetisms, nonetheless, it is also possible to have excellent nature encounters in Fanø¸'s lovely landscapes. In the dune, in the vineyard in the center of the island as well as in the large meadows in the direction of east.
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The Forest, the Marsh on the East Coast og and also the Heath South and also West of the Forest are areas with nature and couple of people. Along the paths and also marked paths is where you can see the unique Flora and Fauna of the Island.
Windsports on the Beaches on Fano¸
Said in all modesty, Fanø¸ has a few of the best coastlines in Denmark. Approximately 15km of sandy beach completely without rocks and also pebbles and also generally really child-friendly.
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get more details, go to – Bed and Breakfast


text:
THE leader of Portsmouth City Council believes today marks 'a new chapter in world history' as the clock ticks down to Donald Trump's inauguration as the next US president.
Councillor Donna Jones says it is important Britain strikes up a strong relationship with Mr Trump once he takes his seat in the White House.
It comes as critics of the Republican plan to stage a protest in Portsmouth tonight condemning his appointment as its beamed live on the Big Screen.
Cllr Jones said: 'Today is the start of new chapter in world history, and a new chapter in the long standing relationship between the United Kingdom and the United States of America.
'What has become obvious since the American election is that the president and country, the establishment, will no long we be as one.
'The UK has an established relationship with the country, but now it needs to establish a relationship with President Trump, who has made clear he is his own man.
'It's an important relationship and as a military city, with a carrier arriving in to Portsmouth in the next few months, the HMS Queen Elizabeth, a ship that will be part of the British American Carrier Strike Force, I will be watching very carefully how the relationship with President Trump develops.'


text:
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text:
The economic argument for generics:
As healthcare costs rise, governments around the world have looked to generics as one means of slowing expenditure. A commonly cited study, by those supporting the increased use of generics, is one by the US Congressional Budget Office (CBO) which estimated that in 1994, purchasers saved between US$8 billion and US$10 billion by substituting generic drugs in place of brand name products (1). In a recent presentation to the US Department of Health and Human Services (HHS), Kathleen D. Jaeger, President and CEO of the Generic Pharmaceutical Association suggested that for every 1% increase in the utilisation of generics, there would be a 1% increase in savings for those paying for prescriptions (2).
Becoming innovative:
Although generics have an important role to play in healthcare there remains a high demand for innovative medicines. The development of novel medicines is necessary to tackle areas of unmet medical need and chronic disorders for which current treatments are inadequate. In fact, one of the criticisms commonly levelled at the pharmaceutical industry is that it has become less innovative over time. For example, in 2002 only 28 new molecular entities (NMEs) were launched onto the world market, whereas in 1982 around 48 NMEs were launched globally (3, 4).
As this demand for new innovative drugs has grown, a number of generics companies have become interested in extending their R&D programmes to make their products appear more than simple copies of their branded competitors. A number of generics companies have developed so-called super generics, which offer consumers added value through special formulations and delivery systems. However, other generics companies are running innovative R&D programmes alongside their generics production and are looking to take advantage of the sales opportunities in the brand name pharmaceuticals market.
Shifting focus:
Only a few generics companies can manage this shift in focus as the expenditure required for innovative R&D is high and the risks are considerable. Generics companies aspiring to become innovative R&D-based organisations need to be proactive in learning about the challenges they will face, particularly during clinical trials as innovative R&D is very different to that for generics. As they are already viable businesses they should have a commercial advantage over academic biotech start-ups that have often been overambitious in taking their discoveries into clinical development. According to one study by DataMonitor, some generics companies are enjoying profit margins, which are at least comparable with those of the mainstream pharmaceutical industry. The differences in R&D spending as a proportion of sales for the top 18 generics companies were compared with those for the top 15 R&D-based pharmaceutical companies (5). According to this study, whilst generics companies spent a lower proportion of their sales on R&D compared to the R&D-based pharmaceutical companies, their average operating margin was 21.3%, only slightly below the figure of 23.6% for the R&D-based pharmaceutical companies cohort (5).
Confounding the doubters:
Many observers are sceptical that generics companies can make the transformation to becoming innovative drug development organisations, but examples of success in this area do exist.
Pliva is one organisation that has successfully combined its work in generics with innovative R&D. It was responsible for the discovery of the highly successful antibiotic azithromycin, which was eventually marketed by Pfizer as Zithromax. In 2002, Zithromax was the most prescribed brand-name oral antibiotic in the USA and the second largest selling antibiotic worldwide (6). Pliva has used its growing revenue to create a balanced business with 72% of its research focused on generics and speciality chemicals and the remainder on R&D for new chemical entities (NCEs) (7).
Another generics company with a major NCE product is Teva. In the USA it markets approximately 140 generic products, but has been developing innovative drugs in the neurological and autoimmune therapeutic areas (8). Teva's major success has been the innovative drug, Copaxone (glatiramer acetate) which represented the first nonsteroidal, non-interferon agent for relapsing-remitting multiple sclerosis (MS). It is sold in 42 countries and is now well established as one of the leading MS therapies (8). IVAX is well known for its strong generics pipeline, but it has a growing NCE pipeline in the respiratory, oncology, central nervous system, gastrointestinal, urology and endocrinology therapeutic areas. IVAX's Uroflux, a new drug to treat benign prostatic hypertrophy (BPH) successfully completed phase II trials in early 2004 (9).
These are just examples of the innovative efforts by generics companies, but whether these organisations can go on and build on this initial success in the NCE field is yet to be seen. However, even smaller companies are now making steps in this direction. Yet there a number of additional market factors that these companies must consider as they develop their NCE R&D programmes. One of the ironic difficulties of becoming involved in NCE development is that these products will eventually themselves be subject to generic competition when their patents expire. Thus the longevity of the revenue stream gained through NCE sales could be uncertain. Furthermore, these companies will have to contend with the same economic, regulatory and political pressures as those organisations whose core activities are NCE development and commercialisation.
Nevertheless, if generics companies can balance both generics and NCE activities, they may be able to benefit from the advantages that both types of products can offer in the context of the global healthcare environment. With governments emphasising cost containment there will be a greater use of generics as alternatives to brand name drugs. Yet equally, if serious and chronic diseases are to be tackled effectively there will be a continuing demand for innovative, disease modifying drugs.
1. How increased competition from generic drugs has affected prices and returns in the Pharmaceutical industry (1998). Congressional Budget Office http://www.cbo.gov/
2. Jaeger KD (2004). More Generic Pharmaceutical Utilization, Not Unregulated Drug Importation, Answers America's Drug Cost Crisis. GPhA Testimony: HHS Task Force on Drug Importation.
3. Sculthorpe P. and Lowman D. (2003). New Medicine Launches 2002. CMR International. http://www.cmr.org
4. Kermani F and Findlay G (2000). The Pharmaceutical R&D Compendium. CMR International. http://www.cmr.org/
5. Hansen N. and Tunnah P. (2003). The generics challenge: Seeking the elusive profit margin. Journal of Generic Medicines. Vol 1 (1): 6-12.
6. Pfizer Inc 2003 Performance Report. http://www.pfizer.com/
7. Vuksic Z (2004). Pliva corporate presentation of 2003 annual results. London, 25th February 2004.
8. Teva Reports Record Sales And Net Income For Q4 2003. Teva Press Release. February 17, 2004. http://www.tevapharm.com/
9. R&D Overview. IVAX. http://www.ivax.com/jsps/research/rd_overview.jsp
Last updated on: 27/08/2010 11:40:18
PharmiWeb.com is Europe's leading industry-sponsored portal for the Pharmaceutical sector, providing the latest jobs, news, features and events listings.
The information provided on PharmiWeb.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician.


text:
So it's been about 6 months since I released the first edition of the Video Pack. Since then I've added a few clips and it currently totals around 50 but, after updating the Trading Guide last month I thought it'd only be right to do the same! Further still all the positive emails I've had after the last update have been encouraging so thanks!
With the lull in the markets at the moment its prime time to make a few changes and updates, so you've probably guessed it but like I did before updating the guide I'd like any feedback/suggestions from existing Video Pack users so I can do my best to incorporate it, email too – firstname.lastname@example.com. Making sure it's the very best it can be is my aim!! Currently I already have a few additions to render and add so I'd expect there to be around 10+ more!
I'm going to set the update completion date at the 4th October 2014 to make sure I keep motivated, so if you can mail any suggestions through as soon as possible it would be preferable (before the end of the month preferably). I'm fully aware some of the clips have been really quite popular with users and more examples have been suggested so take a second to let me know which ones! The execution strategy clips seem to have been favourite so far.
All existing users will be able to view the update and any future update via the login portal provided on purchase, if you've lost your details just drop me a mail and I'll re-send the info.


text:
Want something special?
Tell us what you need. We'll get it for you.
Not seeing that perfect beer at any of your usual stops? Just fill out this form and let us know what you're looking for. We will contact all our suppliers and do everything in our power to put it in your hands. If it is available from any of our wholesalers, we can get it.
Expect a response from us via phone or email including availability information and a price quote, if attainable. Full cases or kegs only.
Remember – If ordering a seasonal release product, please submit 2-3 months prior to its release or it will potentially be too late for us to bring it in.


text:
One of the burdens imposed on most companies is the need to have a statutory audit.
Our clients receive more than just the standard auditing services. We view the audit as our opportunity to build on our existing ethos of being pro-active advisors intent on adding value to our clients' businesses.
Clients receive professional advice and assurance on their controls and accounting systems all year round because we understand them and their business. The same principles are applied when carrying out accounts preparation work for those clients for whom audit accounting is not required.
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So after a relatively painless flight with very gourmet PB & J sandwiches lusciously displayed in ziploc bags for security purposes, we made it into Portland and headed straight to PARADOX CAFE!
What to say about PARADOX CAFE… if there was a dish that could save the world from its sins… it just might be PARADOX CAFE's Tofu Benedict. It was as if the Vegan Gods of Compassion so loved the world that on top of decreasing violence, heart disease, diabetes, cancer and general world shiftiness they also decided to gift all that to the people smothered in vegan hollandaise sauce. Win.
With un-relenting gratitude,
The Vegangelicals


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Special Offers
Dec 29, 2018
NEW YOGA CLASSES FOR NEW YEAR, Iyengar Wed 7.15-8.45pm and Sunday 5=6.30pm, Yin Yoga Mon 6.45-8.00pm
Iyengar Wed 7.15-8.45pm with Ewa Burgess, Sunday 5-6.30pm with Ewa & Chris Burgess. Cost £9 per class. Yin Yoga 6.45-8.00pm Cost £48/6 weeks or £9 drop-in with Lenora Darlison. For further information, please see Courses and Classes web page. To book, please contact the clinic.
View all news


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By completing your order, you understand that the products(s) you are purchasing are U.S. models and may have power / voltage requirements different from that of your country.
Prices shown in currencies other than US Dollars are estimates based on current exchange rates. We will charge your credit card in US Dollars on the day your order is shipped, and the conversion to your local currency will be done at the prevailing rate by your credit card issuer.
ProSound and Stage Lighting will not mark your parcel as a "gift", declare a value lower than the actual price paid, or otherwise prepare false customs information.
The QUAD-BEAM 7 is a compact yet powerful LED BEAM Moving Head that produces bold and colorful aerial effects; built for small- medium size install or any mobile stage lighting environment.
This exceptional bright fixture features (7) 12W OSRAM 4-IN-1 (Red, Green, Blue, White) LEDs and emits over 80-watts of total output power. An ultra compact beam fixture, QUAD-BEAM 7 produces the next level of spectacular colorful aerial effects with pure color mixing.
Easily create a spectacular lighting show by combining several QUAD-BEAM 7 fixtures together.Features


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I've written often enough about how much I enjoy the Peter Grant books, even if I thought the last couple weren't quite as good. This little novella is a return to form, a streamlined and engaging tale set in the magical world of Grant, Nightingale, and the Folly, with Grant's precocious cousin Abigail along for the ride. While the story leans a little more heavily on Abigail than I 100% enjoy, it's such a quick, fun read that I can overlook that.
Short summary: ghosts are turning up to hassle riders on the Metropolitan Line and it's down to Grant to figure out why. Kinda difficult when the riders forget the interactions almost as soon as they occur. That is, spooked commuters call the police only to wonder why the police turn up because the can't even remember calling them.
I won't say more so as not to give anything away. In short, I can highly recommend this one, though if you aren't yet familiar with Grant some of it might sail past you in a blur. This is a series that really needs to be read in order.


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Online Resident Businesses as a voter bloc
It appears a new breed of voter has emerged very quickly from the tumult engulfing Loudoun County's development and transportation morass. Leaving aside the party faithful and religious right, many residents can be neatly partitioned into smart-growth or anti-growth categories (thereby trending Democratic), or dyed-in-the-wool by-right (i.e. larger landowners, businesses unto themselves, and therefore trending Republican). Most local businesses and business owners tend to stray pro-growth or by-right, and therefore support the Snow agenda (in this area, at least). But what about those voters who are both residents AND business owners, primarily home-based with no large physical infrastructure investments? Mom-inventors, Real Estate agents, home-based Internet businesses and Ebayers, etc. There's a lot of this going on in the Dulles Region; most have an online presence that's locally-oriented, though nationally or globally extended.
I'll call this voter class "ORBs" - Online Resident Businesses. On the one hand, as residents who work from home, uncontrolled or ill-planned growth severely impacts the ability to schedule and meet overlapping family and business demands, including visiting suppliers, receiving inventory and collaborating with local partners. On the other hand (non-local Internet clientele notwithstanding), more business and residential growth means potentially more business, affiliates, partners, suppliers and others participating in the virtual business network (on and offline).
Metaphorically-speaking, an ORB absorbs and reflects equivalently in all directions, as a sphere. That's the foundation of the ORB vote, where the sum of the issues and opportunities is not necessarily greater than the whole - it's the actual sum that matters, corresponding directly to business success and family harmony (or not). So, come November, the sum of all the issues, partisan platforms, on and offline news, economic climate, and all other vectors will likely point the ORB towards a compromise vote regardless of candidate personality, political affiliation or past record.
So, how many ORBs make up the approximately 40,000 persons living in the Dulles South area?
(reprinted in full from an earlier but somewhat old and buried bbs post on Dulles South Online).


text: After a series of encounters in Spain, a modern-day mermaid (Jun Ji Hyun) follows her love, Heo Joon Jae (Lee Min Ho), to Seoul to reunite with him. Unaware that she's a mermaid, he is intrigued by the peculiar girl and names her Shim Chung. Despite traveling miles to be with him, the innocent Shim Chung is unaware that Joon Jae is skilled conman. He works with Jo Nam Doo (Lee Hee Joon), a veteran conman who taught Joon Jae the trade, and Tae Oh (Shin Won Ho), an expert hacker.


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Walk Into the Blue
- Artist: Babelfish
- Format: CD
- Release Date: 12/31/2002
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BABELFISH BIOGRAPHY Babelfish consists of Kerrin Brizzell on violin and vocals, and Tim Nash on guitar and vocals. Kerrin was born and grew up in Christchurch, New Zealand where she started learning the violin at the age of 7. She continued to study, completing a music degree at Canterbury University and playing for the Christchurch Symphony Orchestra for 10 years in the 80s. At the same time she was teaching violin privately, and music at Cashmere High School. On moving to England in 1989 Kerrin began to develop her playing in a variety of different styles. She continued to play in orchestras and studied viola with Roger Best in London for a time before moving into the world of folk music and jazz. Tim Nash is from London and has been playing acoustic, electric, and bass guitar in bands for many years, as well as writing songs from an early age. He is self-taught and plays many different styles including classical guitar. Babelfish was formed in 1998 in Norwich, when Kerrin and Tim began to work together. They play a great variety of styles including traditional folk music, gypsy and East European music, a little light jazz, and arrangements of classical music. They have been working on original songs together to create their debut album called Walk into the Blue, which is a mix of folk, pop and roots styles, with strong harmonies between the two voices. The CD was released in May 2002. Babelfish have played at Folk Clubs, Festivals and Fairs, Arts Centres, and Pubs in and around East Anglia in England for the last 3 years, and have also played at Summertimes in Christchurch, New Zealand (2001). For more information they can be contacted on: firstname.lastname@example.com.


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A lot has happened in the Bonnan Lab at Stockton these past few months.
First, the "Rat Pack" as I fondly call them (Evan Drake, Kadeisha Pinkney, and Radha Varadharajan), presented their research proposals for 3-D rat locomotion and kinematics to the Northeastern Regional Vertebrate Evolution Symposium (NERVES) on March 22nd, 2013, at the New York Institute of Technology (NYIT) College of Osteopathic Medicine. Their talks were very well received and we had excellent suggestions from colleagues and scholars. I was especially proud of these undergraduates because they were able to give technical talks to a scientific audience having only worked with me for a few months on their projects. Bravo!
A special thank you to the Symposium's organizers, Drs. Brian Beatty and Matthew Mihlbachler!
You can read their NERVES talk titles below.
Next, they put their collective heads together and, with my input, created a very nice poster for the 2013 NAMS Research Symposium at Stockton.
You can read their NAMS research abstract below as well.
Last, but not least, Radha Varadharajan received the first Robert L. Fines scholarship awarded at Stockton, April 26, 2013, for her work on this research and her future career goals in veterinary medicine. Dr. Fines is a former Stockton alumnus (1975) and is one of the premiere M.D. researchers successfully fighting pancreatic cancer. He is the Herbert Irving Associate Professor of Medicine in the Division of Medical Oncology at the Columbia University College of Physicians & Surgeons in New York, New York. I am honored and proud that Radha has received this award from such a prestigious alumnus.
The scholarship will allow Radha to travel with me to Brown University the week of May 20-24, where we will work with Dr. Elizabeth Brainerd and colleagues X-ray filming the rats walking, running, and landing at their XROMM C-arms facility. Stay tuned and we'll keep you posted on our time and research activities while at Brown.
Finally, I must acknowledge the help of our campus veterinarians, Drs. Ralph Werner and Mary Wilkes, for their efforts in helping me with the rats, as well as our animal caretaker, John Rokita, for his constant help and suggestions on rodent protocols and biology.
I feel truly grateful to have made such a jump to a new college and to already be surrounded by supportive faculty, eager students, and the chance to pursue 3-D kinematics research.
NERVES Talk Titles
Varadharajan, Radha and Bonnan, Matthew F. 2013. Exploring 3-D long bone kinematics in the White Rat (Rattus norvegicus) as a model for inferring forelimb posture in early mammals: Contribution of the scapula.>
Pinkney, Kadeisha and Bonnan, Matthew F. 2013. Exploring 3-D long bone kinematics in the White Rat (Rattus norvegicus) as a model for inferring forelimb posture in early mammals: Contribution of the humerus.
Drake, Evan and Bonnan, Matthew F. 2013. Exploring 3-D long bone kinematics in the White Rat (Rattus norvegicus) as a model for inferring forelimb posture in early mammals: Contribution of the radius and ulna.
Forelimb movements in Rattus norvegicus (white rat) and their relationship to pronation: implications for early mammal forelimb posture
Varadharajan, Radha; Pinkney, Kadeisha; Drake, Evan; and Bonnan, Matthew F.
Rattus norvegicus (the white rat) is a therian mammal with a forelimb morphology similar to that of early non-cursorial mammals. Currently, early mammal limb posture is controversial, with reconstructions ranging from sprawling to parasagittal. With this current ambiguity, the study of forelimb shape and movements in R. norvegicus may provide a model to infer the locomotor patterns of earlier mammals. Previous research, most notably by Jenkins (1971, 1974), indicates that the forelimb posture of rats does not follow simple, pendulum-like mechanics but rather a more complex, less-upright range of movement. For the first time, we will study the 3-D morphology and kinematics of the forelimb in R. norvegicus by utilizing three-dimensional moving X-ray animations generated through the XROMM (X-ray Reconstruction of Moving Morphology) technique. Specifically, we will focus on the three-dimensional movements of the scapula, humerus, and antebrachium (radius and ulna), and their combined contribution to pronation (placing the hand palm-side down). To this end, we will test three interdependent hypotheses on the contribution of each of these limb segments to pronation. For the scapula, we examined the serratus anterior, supraspinatous, infraspinatous, spinotrapezius, acromiotrapezius, and rhomboids major and minor. Data gathered on the rat scapula through literature and dissection lead to the hypothesis that this element contributes in a significant way to pronation. Specific features of the humerus distinguish the parasagittal from the sprawling stance in early fossil mammals: degree of torsion, condylar structures of the elbow joint, width of the intertubercular groove, and the relative sizes of the lesser and greater tubercles. These features are associated with major locomotor muscles such as the pectoralis major and minor, deltoids, and pronator teres. We hypothesize that the humerus will contribute in a significant way to the pronation of the hand in the white rat. In humans, the radius can rotate about the ulna to pronate the hand because these elements are bowed, creating the space necessary to allow such movements. The pronator teres and pronator quadratus pull on the radius and rotate it about the ulna, whereas the supinator and biceps brachii act as antagonists to return the bones to a parallel position. Unlike humans, the radius and ulna of Rattus norvegicus fit tightly together like two spoons stacked together, with little, if any, space available in which the radius can rotate about the ulna. Moreover, the pronator quadratus has not yet been described or identified in our rat dissections. Instead, the radius and ulna appear "fused" by the interosseous membrane and rendered incapable of supination. Rats have little need to supinate the forelimb because the forelimbs are primarily used in locomotion. It is therefore hypothesized that all pronation and supination occur in the humerus and scapula in rats because the radius and ulna are in such close proximity to each other that we infer they participate little, if any, to pronation. After we capture the three-dimensional movements of these bones with XROMM, we will test our hypotheses and perhaps gain insight into the posture of early mammals.


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Minor Hotels takes Anantara into Mozambique with Rani Investment
Minor Hotel Group, a hotel owner, operator and investor, has announced the formation of a long term strategic partnership agreement with Rani Investment, the owner of high end resorts across Africa.
The two organisations have formed a joint venture company for ownership of Indigo Bay Resort & Spa in Mozambique, with plans for further expansion in Africa.
Located on Bazaruto Island, 30 kilometers off the east coast of the country, Indigo Bay is a five star 44-villa resort, and will be re-branded to Anantara Bazaruto Island Resort & Spa later this year and managed by Minor Hotel Group.
This new addition to MHG's portfolio takes the number of properties in operation to 94 and adds a new country of operation, taking the total to thirteen.
The new strategic partnership will explore more opportunities in Mozambique, including in the capital Maputo, and in the vibrant East Africa market to further strengthen MHG's presence on the continent.
These properties will be a mix of new-build and re-brand and will be flagged with MHG's international hotel brands, including Anantara, the recently launched contemporary upscale brand AVANI and the serviced apartment Oaks brand which is currently expanding into Asia and the Middle East.
Dubai-based Rani Investment is the investment arm of Aujan Group Holding with more than US$300 million of dedicated investments in the Middle East and Africa.
Rani Investment is the largest private hospitality owner-operator in Mozambique, having first established its presence in 1999 under the Rani Resorts name.
Dillip Rajakarier, chief executive, Minor Hotel Group, commented: "We are excited to be partnering with Rani Investment and are looking forward to working closely with them to grow our portfolio in Africa, specifically in Mozambique to begin with.
"We are already present in Tanzania and Kenya through our partnership with Elewana Collection and we are keen to expand further into other parts of this vast continent where there is so much untapped opportunity."


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Caribbean Literature
The evolution of Caribbean Literature started centuries before the Europeans graced these shores and continues to develop today. Quite noticeably, it developed in a manner which transcended all language barriers and cultures. Today the languages of the Caribbean are rooted in that of the colonial powers - France, Britain, Spain and Holland - whose historical encounters are quite evident throughout the region. The cosmopolitan nature of the region's language and cultural diversity develop from the mixture of European languages with Native American languages (mainly the Caribs and Arawaks) in the formation of creoles and local patois (hybrid languages) and those of Africans brought to the Caribbean as slaves, not withstanding the contributions of Asians mainly from India and China, and Middle Easterners.
The fabric of Caribbean Literature is woven with the historical issues of enslavement and forced migration, the related themes of home and exile, and colonialism and decolonization. The social and cultural themes of tradition, landscape, culture and community are also encompassed by Caribbean Literature. It also addresses such universal questions as identity, sexuality, family life, pain, joy, and the uses of the imagination.
It is virtually impossible to keep Caribbean Literature only within the confines of writings produced within the Caribbean Islands. Caribbean Literature also transcends the borders of Central and South America extending to the shores of Guyana, Suriname, French Guiana; and coastal areas of Colombia, Nicaragua, Belize and Honduras. Evidence of aspects of Caribbean Literature can also be seen in literary works produced in various areas of the USA including Miami and New Orleans. Works of Caribbean Literature have also been produced by people of Caribbean ancestry who live primarily in Europe and major urban centers of the United States.
Oral literature can be considered as the earliest form of Caribbean Literature consisting mainly of rich folk- tale traditions, legends and myths, songs and poetry. Today this legacy is resplendent in popular music such as the CALYPSO, the Cuban SON, and the Puerto Rican BOMBA; in the traditions of storytelling originating out of West Africa and India; and in supernatural tales from African religions, including SANTERIA, LUCUMI,VODUN (vodoo), and SHANGO. Proverbs, riddles, and sayings that reinterpret African, European, and East Indian traditions are also most prominent in Caribbean literature. Among these are Anancy (a cunning spider) stories; animal dilema tales, which typically teach a moral lesson; stories of village life or evil women; tall tales; and rhetorical flourishes, such as boasting, toasts, and speeches.
Autobiography and poetry were the most prevalent literary works from the 16th century to the mid - 19th century. In these works were introduced themes that became common in Caribbean literature; exile, migration, displacement and questions of identity. The history of Mary Prince, a West Indian Slave, (Related by Herself), is the most prominent of these writings in English. Early Caribbean writings in Spanish saw that of the autobiography of the slave Juan Francisco Manzano of Cuba in the 1820's and 1830's, Jose Maria Herida Placido ( a slave who was executed in1844 for his role in a slave uprising) and the Cuban anthropologist Miguel Barnet. Max Urena of the Dominican Republic produced nationalist works in the 19th century. The French speaking Caribbean saw works by Emeric Bergeaud and Desmevar Delorme.
Distinct national literary traditions began in the 20thcentury because few Caribbean countries gained their independence before this period. Twentieth century Caribbean literature can be divided into three periods: the first thirty years during colonial rule; the years just prior to independence between the 1940's and 1960's or later, and the...
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That Was Close!
OK, so I almost lost my domain. I actually had auto-renew on, but that doesnt help out much when you dont have money in the account :) So anyways, I am alive and kicking again.
This will also serve as a formal announcement that a few months ago the flogspot.com domain suffered a similar fate. Unfortunately I was unable to get it back. If you would still like to visit the site, you can do so by visiting http://www.duramedia.com/~flogspot/. I think I will probably be giving the 'much in need of care' code to Keran McKenzie over at Studiowhiz, so you may see it there soon enough.
2 Responses to 'That Was Close!'
well done dude….
Sad to hear about FlogSpot but of course Studiowhiz will be keen to look at working with you to get this back up and running
hotmail.co.uk wasn't that lucky:


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It's nice to see Stephen J. Dubner, of Freakonomics fame, lending some of his publicity lustre to sociologist Sudhir Venkatesh, who's written what promises to be a fascinating book on his field work for his dissertation – as a participant/observer in the gang life of the Chicago projects:
Now a professor of sociology at Columbia University, Venkatesh ventured into Chicago's Robert Taylor Homes housing project in the 1990s to do research for his doctorate. He befriended the leader of the Black Kings, one of the country's largest and most violent crack-dealing gangs, and led the group for a day. Venkatesh's new book, Gang Leader for a Day, captures his years inside the projects and how residents and gang members interacted, coexisted and raised families.
Via barry at investigativeblog, you can follow this link to a podcast of an interview with Venkatesh. The purpose of the research is described in this piece from the Chicago Sun-Times, which also features a podcast of Venkatesh reading from his book.
I'm also pleased to see a revival of this sort of ethnographic observational fieldwork in the sociology of deviance, which has become too obsessed with a narrow instrumentalism in proposing policy for crime prevention, or various theoretical dead ends. It's reminiscent of the work of the originator of labelling theory, Howard S. Becker, who wrote his dissertation while working as a jazz pianist in the 50s and published a book in 63 on what would these days be called the "night time economy" of drugs. It's fitting that Venkatesh did his graduate work at Chicago – the Chicago school of sociology lives on.
<img src="http://larvatusprodeo.net/wp-content/uploads/2008/01/venkatesh_.jpg"