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Grazed from Whir. Author: Cheryl Kemp.
Nearly all organizations would use hybrid cloud if the public Internet structure could be made more secure, yet most of them (57 percent) are migrating back to private clouds due to security and data protection concerns. According to 1,000 interviews with senior IT decision-makers conducted by Vanson Bourne on behalf of Tata Communications, cloud computing has been widely adopted yet concerns over security remain an obstacle to wider use.
Although most of organizations have some type of cloud, not all the data is stored there. Even though most companies would move to the cloud tomorrow if it were possible, only 28 percent of data is stored in the cloud and only 42 percent of infrastructure is virtualized. One of the barriers to more widespread cloud adoption and use is application readiness...
Grazed from CCSKGuide. Author: Editorial Staff.
The DoD's new Cloud Computing Security Requirements Guide (SRG), released by the Defense Information Systems Agency (DISA), replaces their previous Cloud Security Model. The guide outlines an overall "security posture" that directs cloud service providers (CSPs) seeking to work with the DoD. This article is a continuation of a previous one, which introduced the four new information impact levels. Here, we will examine the DoD process of risk assessment of cloud service offerings, as defined by the SRG.
Risk Assessment Process
Shifting to cloud computing means that risk management processes must change as well. The goal is to address requirements and controls, relative to the criticality of DoD information in the external cloud, in a cost effective way. At the same time, it is also to assure the security of DoD core missions and networks in accordance with the DoD RMF...
Grazed from TheRegister. Author: Iain Thomson.
The US Congress, now fully under Republican control, is getting busy with laws to protect data: two bipartisan bills appeared on Thursday that would bring the 1986 Electronic Communications Privacy Act (ECPA) bang up to date in the 21st century. The first piece of proposed legislation [PDF] is the Electronic Communications Privacy Amendments Act of 2015, submitted in the Senate by Senators Mike Lee (R-UT) and Patrick Leahy (D-VT) and in the House by Representatives Kevin Yoder (R-KS) and Jared Polis (D-CO).
The bill would require cops and the Feds to show probable cause when seeking a search warrant to rifle through people's emails and other data. (California is mulling over a similar requirement.) Under today's rules, set back when Ronald Reagan was in the White House, deem that any email can be searched, with probable cause or not, provided at least 180 days have passed since the message was sent and received...
Grazed from Reuters. Author: Steven Scheer.
Team8, an Israeli venture capital fund focused on the cyber-security industry, said on Tuesday it had raised $18 million in its first round of funding, including investment from Alcatel-Lucent and Cisco . Also participating in the round were Bessemer Venture Partners, Marker LLC and Innovation Endeavors, which was founded by Google executive chairman Eric Schmidt.
Led by veterans of the Israeli army's 8200 intelligence and electronic espionage unit, Team8 aims to develop cyber-security companies that offer more in-depth protection than the usual defence against hacking attempts by generic malware. Bessemer partner David Cowan said that could set them apart from the legions of security start-ups in Silicon Valley...
Grazed from MarketWire. Author: PR Announcement.
Bitglass, the Total Data Protection company, announced today that it has joined the Cloud Security Alliance (CSA), a not-for-profit organization with a mission to promote the use of best practices for providing security assurance within cloud computing. Bitglass is a Cloud Access Security Broker that delivers total data protection as enterprise data moves beyond the firewall -- in the cloud, on mobile devices and anywhere on the Internet.
The service enables some of the world's most security-conscious and regulated organizations to adopt public cloud apps by closing security and compliance gaps. The SaaS-based solution deploys in minutes and works without installing software agents on employee devices and without changing the user experience...
Grazed from TechTarget. Author: Beth Pariseau.
IT pros considering IBM SoftLayer and Amazon Web Services will find solid security in both clouds, though true cloud security should ultimately be something the user controls, experts say. IBM SoftLayer and Amazon Web Services (AWS) both cater to enterprises with extensive cloud security features, as well as marketplaces full of third-party products to secure the customer's side of the cloud.
Much of AWS cloud security revolves around encryption. It encrypts data at rest in the Simple Storage Service (S3) and Elastic Block Store (EBS). With the AWS Key Management Service, Amazon offers customers a choice of using master keys managed by AWS for encryption or controlling their own keys...
Grazed from Talkincloud. Author: Dan Kobialka.
A new MeriTalk survey of 300 U.S. federal IT decision-makers showed that the number of reported breaches on U.S. federal computer networks has nearly doubled since 2009. The majority of these professionals are concerned about cybersecurity as they update their data centers as well.
The survey, underwritten by Palo Alto Networks (PANW), revealed 67 percent of U.S. Feds are concerned with cybersecurity as they modernize their data centers. Also, 49 percent said they believed that the data center modernization process makes cybersecurity more challenging...
Read more from the source @ http://talkincloud.com/cloud-computing-research/02032015/how-are-feds-handling-data-center-defense
Grazed from BetaNews. Author: Editorial Staff.
Many of the things we do online require an ID and password, but typically whilst this makes things easier for the site it doesn't always do a lot to protect the user, who may be revealing more information than they need. For example you may have to reveal your full date of birth and address to a video streaming service in order to verify your age and region, running a risk that the information may fall into the wrong hands.
Now researchers at IBM have announced plans for a new cloud-based technology to help consumers guard their personal data. The technology, called Identity Mixer, uses a cryptographic algorithm to encrypt the identity attributes of a user, such as their age, nationality, address and credit card number in a way that allows the user to reveal only selected pieces to third parties...
Grazed from TechCocktail. Author: Santosh Satya.
A little more than a decade ago, three famous paintings were on display at the Whitworth Gallery, an art museum in Manchester, England. Since the works of Gauguin, Picasso, and Van Gogh were valued at about $8 million, they were heavily protected by security guards and electronic systems. Guards patrolled the gallery. Alarms were set in place. And closed-circuit television scanned the paintings.
Still, none of this was enough. Burglars broke into the Whitworth Gallery in late April, 2003 and stole the three paintings. A few days later, the expensive masterpieces were found in a public restroom near the art museum. A note attached to the masterpieces dismissed the episode as a caper designed to test the woeful security measures. This bold art burglary is a lesson for network administrators who guard information systems...
Grazed from MidsizeInsider. Author: Marissa Tejada.
Keeping sensitive data and information safe is top of mind for the U.S. Department of Defense (DoD). The agency's new cloud computing security requirements are relevant for cloud computing vendors seeking to help midsize firms secure their data.
What the Guidelines Mean
The DoD's new Cloud Computing Security Requirements Guide, released by the Defense Information Systems Agency (DISA), replaces their previous Cloud Security Model. According to WHIR, the guide outlines an overall "security posture" that helps guide cloud service providers seeking to work with the DoD. These new guidelines were designed with agency security in mind, outlining how the public cloud can be utilized without compromising proprietary data...


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"Hotel brand executives are beginning to embrace OTAs again, even calling them partners, as companies such as Expedia and Priceline work through complex negotiations with many of the major brands.
OTAs are "a definite part of the value chain," said Pat Pacious, executive VP of global strategy, distribution and technology for Choice Hotels International. "When your hotel is looking to discount, they're a viable channel."
Accor Hotels recently signed a long-term global agreement with Expedia; Jean-Luc Chrétien, Accor's executive VP of sales, distribution and loyalty programs, called the relationship "fruitful."…
The change in tune could be pinned to a number of driving factors.
First, hotel suppliers typically rely less on third-party intermediaries during times of high demand. With occupancy nearly back to pre-recession levels and U.S. hotels selling more room nights annually than ever before, suppliers could find themselves in the driver's seat having to rely less on OTAs and therefore write fewer commission checks.
Similarly, high demand gives suppliers more leverage when negotiating commissions with partner distributors. According to sources, new brand agreements with Expedia in particular are at lower margins than in the past.
While lower commissions could be a direct result of less dependence on traffic, some argue increased competition in the OTA space is driving down margins…
Perhaps another reason hotel brands and OTAs are seeing more eye to eye these days is the collective hurdles they face with Google, which has made a grand entrance into the travel research and booking space. Google is capitalizing on the fact that many travel researchers start with a search engine to drive up the cost of keywords and cost-per-click revenue.
Getting traffic from Google is a costly proposition hotel brands and OTAs fear will only rise."
So what do you think? Will this be a trend only for flagged properties or will boutique hotels also embrace OTAs once again?
Read the full article at HotelNewsNow: Brands, OTAs mending relationship.

subset: commoncrawl


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In August 2017, Google announced the Google Universal Analytics Global Site Tag.
The announcement triggered a few discussions on Twitter, with digital marketers and IT folks worldwide asking: "is it time to upgrade already?"
This post explains what is at stake with the Global Site Tag and why you should switch – or not.
What is the Global Site Tag?
The Global Site Tag (gtag.js) is a new version of Google Analytics' JavaScript capture API, currently using analytics.js for web pages and web apps.
At the end of the day, both analytics.js and gtag.js both leverage and send data to the Measurement Protocol, Google Universal Analytics' data collection API.
Why would Google release the Global Site Tag now?
Even the in-page Google Universal analytics (analytics.js) makes some use of JSON to supercharge hit requests:
[code lang="js"]ga('send','pageview','/mypage.html',{
'dimension1': 'blog',
'dimension2': 'english'
The Global Site Tag using gtag.js makes use of the Google Tag Manager data layer methods and infrastructure, as shown below:
[code lang="html"]
<!– Global Site Tag (gtag.js) – Google Analytics –>
<script async src="https://www.googletagmanager.com/gtag/js?id=GA_TRACKING_ID"></script>
window.dataLayer = window.dataLayer || [];
function gtag(){dataLayer.push(arguments)};
gtag('js', new Date());
gtag('config', 'GA_TRACKING_ID');
This methodology can be extended to add clear parameters for hits:
[code lang="js"]gtag('config', 'GA_TRACKING_ID', {
'page_title': 'homepage',
'page_location': 'http://foo.com/home',
'page_path': '/home'
And the Global Site Tag also allows for predefined values for events, which auto-widens event categories or actions based on event labes for instance.
But don't take it from me and look at posts by esteemed colleagues:
- E-Nor
- Impression
- Goanalytics (IT)
- Analytics-Insights (DE)
So should I switch to the Global Site Tag?
Luckily for you, I put together a convenient flowchart to help you decide whether you should migrate to the Global Site Tag, as shown below:
… and the short answer is: no, you do not need to migrate to the Global Site Tag for another year at the very least.
As you can see in the flowchart, the decision to migrate to the Global Site Tag boils down to whether you use a TMS – or rather, whether you don't use one. If you use in-page tags, you are in no rush to migrate but if you feel so inclined, Google has a brief Global Site Tag migration guide in the support section.
In the past, Google has warned about decommissioning old versions of their tracking code. For instance, the original urchin.js code introduced in 2005 with the first version of Google Analytics was supposed to be decommissioned after a moment. Back in 2009, when the new ga.js tracking code was around the corner, I was asked my opinion about migrating to the new code and whether Google would stop collecting data on sites using the old code. My advice then was to prudently migrate just in case but history has shown that urchin.js is still around (eeek), ga.js works on quite a few sites in the world (and is still somehow supported by GTM via the Google Analytics Classic tag). The official tag is still very much analytics.js, until Google promotes the Global Site Tag as the default collection method.
In closing
Keep in mind this migration is "just" the adoption of a new tagging syntax, not a functional upgrade. You will not miss out if you stick to in-page Universal Analytics (analytics.js) code so make sure you migrate for the right reason, i.e. you're using old code and need to benefit from Universal Analytics features.
If you are using a TMS such as Google Manager, you will be all set. Unless of course you went the custom tag route and you'll need to maintain the new libraries yourself.
What about you? Are you planning to migrate? Have you already migrated? Tell your story in the comments below.


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You are here
- Home
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- News
- DNA Abnormalities Found in Children with Chronic Kidney Disease (CUMC Newsroom)
DNA Abnormalities Found in Children with Chronic Kidney Disease (CUMC Newsroom)
Source: CUMC Newsroom
A significant proportion of children with chronic kidney disease (CKD) have unsuspected chromosomal imbalances, including DNA anomalies that have been linked to neurocognitive disorders, according to a new Columbia University Medical Center (CUMC) study. The findings suggest that routine genetic screening of children with CKD could lead to earlier and more precise diagnoses, as well as to more personalized monitoring, prevention, and treatment. Details of the study were published today in the online issue of the Journal of Clinical investigation.
"With conventional clinical findings, we often cannot determine the exact cause of CKD in children," said study leader Ali G. Gharavi, MD, professor of medicine and chief of the Division of Nephrology at CUMC. "However, our study shows that using a readily available genetic screening tool called chromosomal microarray analysis, it's possible in many cases to reach a more precise diagnosis and uncover information that can help define a patient's risk for other disorders, such as autism or diabetes."
About 13 percent of Americans are affected by CKD. The disease is particularly serious in children, often leading to complications like high blood pressure, heart disease, neurodevelopmental problems, and behavioral deficits. Roughly half of all cases of CKD in children are caused by birth defects, such as an underdeveloped or missing kidney. CKD can also result from hereditary diseases, infection, toxic exposures, and autoimmune disorders. In many patients, the cause cannot be determined.
Dr. Gharavi, together with lead author Miguel Verbistky, PhD, associate research scientist, and their colleagues, hypothesized that copy number variations (CNVs)—gain or loss of bits of DNA—might provide insights into the cause of CKD in children. The team performed chromosomal microarray analyses of 419 children enrolled in the Chronic Kidney Disease in Children (CKiD) Prospective Cohort Study to determine the prevalence of disease-causing CNVs among various categories of pediatric CKD. The data were compared with genomic data on 21,575 healthy pediatric and adult controls.
The researchers found significant CNVs in 31, or 7.4 percent, of the 419 children with CKD (roughly ten-fold the percentage seen in the controls). The most frequent CNVs were deletions in the HNF1B gene. Loss of HNF1B function is associated with renal cysts and diabetes syndrome, which increases one's susceptibility to kidney malformations, diabetes, and cognitive disorders, among other conditions. Many of the other CNVs that were uncovered were associated with developmental delays, intellectual disabilities, and seizure disorders.
Of the 31 children with significant CNVs, 28 had genetic diagnoses that differed from the clinical diagnosis or that added information that would have altered the care of the patient, according to the study.
"Because kidney problems can be detected early by blood tests, or even by prenatal imaging studies, this offers the opportunity for screening and detecting genomic imbalances before other complications, such as developmental delay, become clinically apparent," said Dr. Verbistky.
"Our findings should change clinical practice," said Dr. Gharavi. "Routine genetic screening of kids with CKD would not only improve diagnosis but also help identify those at risk for complications like diabetes and subclinical seizures, which benefit from early detection and treatment."
The findings also shed light on why children with CKD tend to perform less well in school than their peers. "The prevailing hypothesis," said Dr. Gharavi, "is that their poor academic performance is due simply to impaired kidney function and the burden of having a chronic illness. But our data suggest that these kids may be underperforming because of an underlying genetic lesion that affects both kidney and neurologic function. If so, it's important that we identify these potential problems and intervene as early as possible."
Depiction of genomic imbalances detected in patients with chronic kidney disease. The human chromosomes are shown (numbered). The colored bars represent the pathogenic genomic deletions (red) and duplications (blue) detected in a patient. In total, the study identified 21 different genetic lesions in 31 patients, indicating that most patients had a unique genomic pathology. The size of each bar is proportional to the size of the genomic lesion. (Credit: Dr. Ali Gharavi)
Read the Spanish language version of the release.
The paper is titled, "Chromosomal Microarrays for the Diagnosis of Pediatric Chronic Kidney Disease." The other contributors are: Miguel Verbitsky (CUMC), Simone Sanna-Cherchi (CUMC), David A. Fasel (CUMC), Brynn Levy (CUMC), Krzysztof Kiryluk (CUMC), Matthias Wuttke (University of Freiburg, Freiburg, Germany), Alison G. Abraham (Johns Hopkins Bloomberg School of Public Health, Baltimore, MD), Frederick Kaskel (Albert Einstein College of Medicine, Bronx, NY), Anna Köttgen (University of Freiburg and Johns Hopkins Bloomberg School of Public Health), Bradley A. Warady (Children's Mercy Hospital, Kansas City, MO), Susan L. Furth (University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, PA), and Craig S. Wong (University of New Mexico Children's Hospital, Albuquerque, NM).
The study was funded by grants from the National Institutes of Health (RO1DK082394, 1R01DK080099, 1U54DK104309, and RO1DK082394).


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text:
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text:
The very first Australia-Algeria senior officials' talks happened in Algiers on 2 November 2016. Around the agenda was increasing our financial romantic relationship, together with in relation to trade in items and products and services. Of individual curiosity was Australian expertise in milk generation, Australia's exports in cattle and sheep, and our experience in dry-zone agriculture.
Situation study:Spanish engineering business Typsa sets up in Australia, attracted with the organization opportunities in the transportation infrastructure sector
Remarkably carcinogenic, aflatoxins are lethal in superior doses, with Serious exposure possibly stunting toddler advancement, blocking nutrient absorption and suppressing the immune system.
Associates Find a partnerGet up and jogging within the cloud with assistance from a seasoned partner Become a partnerBuild much more achievement Using the sector's most substantial spouse community Azure for SaaS companiesGrow your SaaS organization with Azure by reaching one hundred million active end users Sign up for totally free and have $200 to spend on all Azure services
You can also obtain top-adjustable and multi-light-weight variations. If you prefer oblique lights, a torchiere ground lamp is a popular choice to ceiling-mounted fixtures. These floor lamp designs shine upward to provide softer lights.
You may want to consider using HTML tables in your internet site. As well as producing HTML tables to current data in rows This Site and columns, You may as well generate HTML tables to arrange information on your Web content.
The institutional companions are intending to make their job sustainable employing a 'educate the why not try here trainer' method, and formalising scholar/educator exchange alternatives.
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Above a decade ago, their everyday living looked as if it would have a extra discover this optimistic switch. A company trained the sisters to create incense sticks. Soon after partaking during the organization, Tirtha shared which they ended up ready to make ends fulfill.
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The workshop strengthened Australia's credentials like a planet chief from the mining sector and presented an opportunity to share working experience and information with Nigerian counterparts as they seek out to develop the minerals sector in Nigeria.
- 341 Visitors


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Research Topics
Genomes and Genes
Summary: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications358 found, 100 shown here
- Monocyte and macrophage heterogeneitySiamon Gordon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Rev Immunol 5:953-64. 2005..of the macrophage lineage has long been recognized and, in part, is a result of the specialization of tissue macrophages in particular microenvironments...
- Fate mapping analysis reveals that adult microglia derive from primitive macrophagesFlorent Ginhoux
Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
Science 330:841-5. 2010Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, the origin of adult microglia remains controversial...
- Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophagesEmmanuel L Gautier
Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, USA
Nat Immunol 13:1118-28. 2012We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable...
- Development of monocytes, macrophages, and dendritic cellsFrederic Geissmann
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 327:656-61. 2010Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system...
- Exploring the full spectrum of macrophage activationDavid M Mosser
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
Nat Rev Immunol 8:958-69. 2008b>Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions...
- A lineage of myeloid cells independent of Myb and hematopoietic stem cellsChristian Schulz
Centre for Molecular and Cellular Biology of Inflammation, New Hunt s House, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 336:86-90. 2012b>Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs)...
- A role for mitochondria in NLRP3 inflammasome activationRongbin Zhou
Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nature 469:221-5. 2011..This indicates that NLRP3 inflammasome senses mitochondrial dysfunction and may explain the frequent association of mitochondrial damage with inflammatory diseases...
- Macrophage plasticity and polarization: in vivo veritasAntonio Sica
Istituto Clinico Humanitas IRCCS, Rozzano, Italy
J Clin Invest 122:787-95. 2012..In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a universe of ..
- The chemokine system in diverse forms of macrophage activation and polarizationAlberto Mantovani
Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
Trends Immunol 25:677-86. 2004..particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue ..
- Alternative activation of macrophages: mechanism and functionsSiamon Gordon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Immunity 32:593-604. 2010..The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.
- MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesityHajime Kanda
Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
J Clin Invest 116:1494-505. 2006..These findings suggest that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice...
- Toll-like receptor triggering of a vitamin D-mediated human antimicrobial responsePhilip T Liu
Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
Science 311:1770-3. 2006..direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide...
- Obesity is associated with macrophage accumulation in adipose tissueStuart P Weisberg
Division of Moleuclar Genetics, Department of Pediatrics, Columbia University, New York, New York 10032, USA
J Clin Invest 112:1796-808. 2003..Of the 100 most significantly correlated genes, 30% encoded proteins that are characteristic of macrophages and are positively correlated with body mass...
- Protective and pathogenic functions of macrophage subsetsPeter J Murray
Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Nat Rev Immunol 11:723-37. 2011b>Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals...
- Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cordKristina A Kigerl
Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, Ohio 43210, USA
J Neurosci 29:13435-44. 2009b>Macrophages dominate sites of CNS injury in which they promote both injury and repair. These divergent effects may be caused by distinct macrophage subsets, i.e...
- Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapyDavid G DeNardo
Department of Pathology, University of California, San Francisco, USA
Cancer Discov 1:54-67. 2011....
- Interferon-gamma: an overview of signals, mechanisms and functionsKate Schroder
Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane 4072, Australia
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Ohio State University, Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Columbus, OH 43210, USA
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Institut National de la Sante et de la Recherche Medicale, Unite 841, Institut Mondor de Recherche Biomedicale, Cell Interactions in the Neuromuscular System Team, Universite Paris 12 Val de Marne, Creteil, France
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Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
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University of Alabama at Birmingham, Birmingham, AL 35294, USA
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Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
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Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
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Institute of Normal Human Morphology, University of Ancona, Ancona, Italy
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Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California 92093, USA
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National Institute of Dental and Craniofacial Research NIDCR, Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, MD 20892, USA
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Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
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Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
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Istituto Clinico Humanitas, Rozzano, Italy
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Instituto de Histologia y Embriologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo CONICET, Mendoza 5500, Argentina
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Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
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Laboratory of Host Defense, World Premiere Initiative Immunology Frontier Research Center, Osaka University, Osaka, Japan
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Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Nat Immunol 12:1035-44. 2011..subpopulations in three lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils...
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Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
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Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
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Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
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Tumour Targeting Group, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
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Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
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Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
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Department of Molecular Biology and Microbiology, Case School of Medicine, Cleveland, Ohio 44106, USA
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Department of Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
J Leukoc Biol 86:1065-73. 2009..Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors.
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University of British Columbia, Biomedical Research Centre, Vancouver, British Columbia, Canada
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Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
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Istituto Clinico Humanitas IRCCS, Rozzano, Italy
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Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
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Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
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Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
Cell 142:687-98. 2010..7 cells and in primary intraperitoneal macrophages. All of these effects are abrogated by GPR120 knockdown...
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Department of Microbiology and Immunology, Cornell University, New York, NY 10065, USA
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Department of Medicine, New York University Medical Center, NY 10016, USA
Cell 145:341-55. 2011..layer of blood vessels leads to the recruitment of monocytes, the cells of the immune system that give rise to macrophages and dendritic cells...
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Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Science 320:674-7. 2008..Our findings implicate the Nalp3 inflammasome in particulate matter-related pulmonary diseases and support its role as a major proinflammatory "danger" receptor...
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Department of Oncological Sciences and Tisch Cancer Institute, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Immunity 38:792-804. 2013Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes...
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Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 9:847-56. 2008..Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal...
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Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
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Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Immunity 38:79-91. 2013Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense...
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Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
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Department of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, CA 91125, USA
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Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
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Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Nat Rev Immunol 11:762-74. 2011..The mechanisms that control monocyte trafficking under homeostatic, infectious and inflammatory conditions are being unravelled and are the focus of this Review...
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Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
Science 272:872-7. 1996..Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophagetropic HIV-1 isolates...
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Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Nature 477:592-5. 2011..Our results identify NAIPs as immune sensor proteins and provide biochemical evidence for a simple receptor-ligand model for activation of the NAIP-NLRC4 inflammasomes...
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Trudeau Institute, Saranac Lake, New York 12983, USA
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Department of Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
Annu Rev Immunol 20:709-60. 2002..CpG ODN also enhance the development of acquired immune responses for prophylactic and therapeutic vaccination...
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Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 11:395-402. 2010..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity...
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Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 64:7022-9. 2004..Although the presence of macrophages in primary tumors is associated with increased metastatic potential, the mechanistic basis for this observation ..
- Macrophages, inflammation, and insulin resistanceJerrold M Olefsky
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0651, USA
Annu Rev Physiol 72:219-46. 2010..of obesity results from a combination of altered functions of insulin target cells and the accumulation of macrophages that secrete proinflammatory mediators...
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Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
Nature 479:117-21. 2011..mice, that caspase-11 (also known as caspase-4) is critical for caspase-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae...
- Conditional gene targeting in macrophages and granulocytes using LysMcre miceB E Clausen
Institute for Genetics, University of Cologne, Germany
Transgenic Res 8:265-77. 1999..one of two different loxP-flanked target genes tested, a deletion efficiency of 83-98% was determined in mature macrophages and near 100% in granulocytes...
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Department of Human Nutrition, University of Illinois at Chicago, USA
J Allergy Clin Immunol 115:911-9; quiz 920. 2005..b>Macrophages are components of adipose tissue and actively participate in its activities...
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Breast Tumor Center, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, PR China
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- Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in miceRavid Shechter
Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
PLoS Med 6:e1000113. 2009Although macrophages (MPhi) are known as essential players in wound healing, their contribution to recovery from spinal cord injury (SCI) is a subject of debate...
- Tumor-associated macrophages and survival in classic Hodgkin's lymphomaChristian Steidl
Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada
N Engl J Med 362:875-85. 2010..Current prognostic models predict the outcome of treatment with imperfect accuracy, and clinically relevant biomarkers have not been established to improve on the International Prognostic Score...
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Institut National de la Santé et de la Recherche Médicale U1016, Institut Cochin, Paris, France
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Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:1528-33. 2006..cholerae cells toward Dictyostelium amoebae and mammalian J774 macrophages by a contact-dependent mechanism...
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Institute of Immunology and Infection Research, School of Biological Sciences and 2 Medical Research Council Centre for Inflammation Research and 3 The Roslin Institute and Royal Dick School of Veterinary Studies, College of Medicine and Veterinary Medicine University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK
J Exp Med 210:2477-91. 2013b>Macrophages (MΦs) colonize tissues during inflammation in two distinct ways: recruitment of monocyte precursors and proliferation of resident cells...
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Department of Medicine, Leon H Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA
Science 328:1570-3. 2010..In mouse macrophages, miR-33 also targets ABCG1, reducing cholesterol efflux to nascent high-density lipoprotein (HDL)...
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Centre d Immunologie Marseille Luminy, Parc Scientifique and Technologique de Luminy, Case 906, F 13288 Marseille, France
Nat Rev Immunol 11:750-61. 2011In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone...
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Istituto Clinico Humanitas, I 20089 Rozzano, Italy
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- Adipose tissue remodeling and obesityKai Sun
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8549, USA
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Department of Dermatology, University of Erlangen, Germany
J Immunol Methods 223:77-92. 1999..This method allows by simple means the generation of high numbers of murine DC with very low B cell or granulocyte contaminations. It will be valuable to study DC biology notably at the molecular level...
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Institute for Systems Biology, Seattle, Washington 98103, USA
Nat Immunol 7:569-75. 2006b>Macrophages respond to Salmonella typhimurium infection via Ipaf, a NACHT-leucine-rich repeat family member that activates caspase-1 and secretion of interleukin 1beta...
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Department of Medicine, Leon H Charney Division of Cardiology, Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, New York 10016, USA
Nat Rev Immunol 13:709-21. 2013..imbalance in lipid metabolism and a maladaptive immune response driven by the accumulation of cholesterol-laden macrophages in the artery wall...
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Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
Nature 475:222-5. 2011b>Macrophages, which are abundant in the tumour microenvironment, enhance malignancy. At metastatic sites, a distinct population of metastasis-associated macrophages promotes the extravasation, seeding and persistent growth of tumour cells...
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Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
Cell Host Microbe 8:471-83. 2010..Our results suggest the formation of spatially and functionally distinct inflammasomes complexes in response to bacterial pathogens...
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Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Nat Rev Microbiol 7:13-24. 2009The pathogenesis of Legionella pneumophila is derived from its growth within lung macrophages after aerosols are inhaled from contaminated water sources...
- SOCS proteins, cytokine signalling and immune regulationAkihiko Yoshimura
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Nat Rev Immunol 7:454-65. 2007..In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function...
- Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophagesLuigi Franchi
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nat Immunol 7:576-82. 2006Gram-negative bacteria that replicate in the cytosol of mammalian macrophages can activate a signaling pathway leading to caspase-1 cleavage and secretion of interleukin 1beta, a powerful host response factor...
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Department of Immunology, University of Washington, Seattle, 98103, USA
J Exp Med 197:1107-17. 2003..Dectin-1, which is expressed at low levels on macrophages and high levels on dendritic cells, contains an immunoreceptor tyrosine-based activation motif-like signaling ..
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Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
Nat Med 11:183-90. 2005..These findings indicate that lipid accumulation in the liver leads to subacute hepatic 'inflammation' through NF-kappaB activation and downstream cytokine production. This causes insulin resistance both locally in liver and systemically...
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Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
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Department of Microbiology, University of Hong Kong, Queen Mary Hospital, SAR, Hong Kong, China
Lancet 360:1831-7. 2002..The biological basis for the severity of human H5N1 disease has remained unclear. We tested the hypothesis that virus-induced cytokine dysregulation has a role...
- The many faces of macrophage activationDavid M Mosser
Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Leukoc Biol 73:209-12. 2003
- Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal EnvironmentDirk Schnappinger
Department of Microbiology and Immunology, Cornell University, 1300 York Avenue, New York, NY 10021, USA
J Exp Med 198:693-704. 2003..the state of this organelle we captured the transcriptional responses of Mycobacterium tuberculosis (MTB) in macrophages from wild-type and nitric oxide (NO) synthase 2-deficient mice before and after immunologic activation...
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Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
Eukaryot Cell 3:1076-87. 2004..albicans to phagocytosis by mammalian macrophages using genomic transcript profiling. This analysis reveals a dramatic reprogramming of transcription in C...
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MRC Centre for Regenerative Medicine, Multiple Sclerosis Society Centre for Translational Research, University of Edinburgh, Edinburgh, UK
Nat Neurosci 16:1211-8. 2013..This involves an innate immune response consisting of microglia and macrophages, which can be polarized to distinct functional phenotypes: pro-inflammatory (M1) and anti-inflammatory or ..
- Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skinSamira Tamoutounour
Centre d Immunologie de Marseille Luminy CIML, UM2 Aix Marseille Université, 13288 Marseille Cedex 9, France INSERM U1104, 13288 Marseille Cedex 9, France CNRS UMR7280, 13288 Marseille Cedex 9, France
Immunity 39:925-38. 2013In the skin, the lack of markers permitting the unambiguous identification of macrophages and of conventional and monocyte-derived dendritic cells (DCs) complicates understanding of their contribution to skin integrity and to immune ..
- The inflammatory response in myocardial infarctionNikolaos G Frangogiannis
Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
Cardiovasc Res 53:31-47. 2002..Monocyte-derived macrophages and mast cells may produce cytokines and growth factors necessary for fibroblast proliferation and ..
- IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responsesThomas Krausgruber
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
Nat Immunol 12:231-8. 2011..Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarization...
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Centre for Immunity, Infection and Evolution, and the Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
Science 332:1284-8. 2011..We reveal that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density...
- TLR4 links innate immunity and fatty acid-induced insulin resistanceHang Shi
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 116:3015-25. 2006..fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and ..
Research Grants74
- Variation in M. tuberculosis in response to host selectionSarah Fortune; Fiscal Year: 2009..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
- Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherALEXANDRA ROSE LUCAS; Fiscal Year: 2010..We have successfully tested one of these serpins, Serp-1, in a small phase 2A clinical trial for anti-inflammatory activity in unstable coronary syndromes (Viron Therapeutics, Inc;proprietary information). ..
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2011..biofilm formation by Porphyromonas gingivalis, cytokine production by LPS- or AGE-stimulated human monocyte/macrophages, matrix metalloproteinase production by IL-12-stimulated human gingival fibroblasts, and AGE-induced inhibition ..
- Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)James D Bryers; Fiscal Year: 2012..Our goal is to develop tissue regenerative biomaterials that will also provide a short-term defense and life long immune response to specific bacterial infections ..
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2013..We then investigate if PM2.5 exposure induced ER stress response in macrophages is central to adipose inflammation and dysfunction by flow sorting and laser capture microscopy and assessed ..
- Prevention of Acute Lung Injury by IL-6 activated STAT3Ana Moran; Fiscal Year: 2010..Pik3r1 and Lcn2-as well as genes encoding proteins- Gzmb and Prf1-that are expressed by neutrophils, macrophages and cytotoxic T-lymphocytes that infiltrate the lung during systemic inflammatory states such as T/HS...
- Enterococcus faecalis, Colorectal Cancer, and Bystander EffectsMark M Huycke; Fiscal Year: 2012..The role of macrophages in the production of inflammation, dysplasia, and tumor formation in E...
- Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative StressSamantha M Yeligar; Fiscal Year: 2013..In alveolar macrophages (AMs), NADPH oxidase (Nox) 1, Nox2, and Nox4 are critical sources of reactive oxygen species (ROS), and Nox2 is ..
- Immunomodulatory and regenerative effects of mesenchymal stem cells on allograftsNorma S Kenyon; Fiscal Year: 2013..IV MSC post-transplant will result in the induction of T regulatory cells, recruitment of regulatory monocytes/macrophages and endothelial precursors to sites of inflammation (i.e...
- Investigating Mechanism of Intracellular Rotational Transport with Optical TJeffrey N Anker; Fiscal Year: 2012..b>Macrophages are the primary defense cells in the lung responsible for uptake, degradation and clearance of foreign ..
- Trichothecene Toxicity and the Ribotoxic Stress ResponseJames J Pestka; Fiscal Year: 2012..Collectively, these outcomes will positively impact public health by providing a scientific basis for generating sound recommendations relative to these important toxins and appropriate remedial actions should exposures occur. ..
- Iron, Metabolic Regulation and Type 2 Diabetes RiskDonald A McClain; Fiscal Year: 2013..The effects of glucose on hepcidin, and subsequent effects on inflammatory signaling in macrophages and adipocytes, will be examined in mouse models with normal glucose tolerance, hyperphagia, diabetes, and with ..
- Mechanisms of hepcidin effects in the anemia of chronic diseaseRobert T Means; Fiscal Year: 2013..Hepcidin inhibits egress of iron from bone marrow macrophages by downregulation of the iron export protein FPN...
- Biology and Pathologies of Type V CollagenDaniel S Greenspan; Fiscal Year: 2013..If such studies are borne out, the ramifications are huge, with profound implications for understanding, evaluating and treating atherosclerotic disease - the number one killer of adult human beings in the western hemisphere. ..
- INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMJERROLD MICHAEL OLEFSKY; Fiscal Year: 2013..Finally, CD11c+ macrophage represents the majority of the macrophages recruited into obese adipose tissues...
- Hepcidin-based screening for infantile iron deficiencyMark D Fleming; Fiscal Year: 2010..iron from cells, particularly duodenal intestinal epithelial cells, where iron is absorbed into the body, and macrophages, which recycle iron from effete RBCs...
- Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated DementiaXavier Grana; Fiscal Year: 2010..Importantly, Tat inhibits cyclin T1/CDK9-dependent gene expression of certain genes in macrophages, dendritic cells and B cells via a competition mechanism with specific transcriptional activators...
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI R HERBERT; Fiscal Year: 2011DESCRIPTION (provided by applicant): Alternative macrophage activation limits immunopathology Macrophages (MF) form a heterogeneous population of mononuclear phagocytes necessary for organ homeostasis, host defense, and immunoregulation...
- Novel Peptide MPO Inhibitors for Treating AtherosclerosisKirkwood A Pritchard; Fiscal Year: 2012..Effects of the inhibitors on MPO activity will be determined in in vitro systems using both purified MPO and macrophages isolated from MPO-/- and transgenic human MPO (Tg-h- MPO+/+) mice...
- Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T cInsoo Kang; Fiscal Year: 2010..For instance, vitamin D3 (VD3) can affect the functions of immune cells including macrophages, dendritic cells (DC), B and T cells...
- Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22Yaya Wang; Fiscal Year: 2013..In Aim 1, I will determine the role of PTPN22 in TLR signaling by using bone-marrow derived macrophages (BMMs) and dendritic cells (BMDCs) from PTPN22 deficient mice...
- Regulation of Innate and Adaptive Immunity in Human COPD and EmphysemaFarrah Kheradmand; Fiscal Year: 2012..In addition to macrophages and neutrophils, lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, ..
- C5a as an Anti-HIV Microbicidal CandidatePHILIPPE ANDRE GALLAY; Fiscal Year: 2013..multiple attractive microbicidal properties: it i) blocks HIV infection of primary targets including T cells, macrophages and dendritic cells;ii) exhibits a broad range of antiviral activity against primary HIV isolates, multi-drug ..
- Lipid Droplet MetabolismFredric B Kraemer; Fiscal Year: 2013....
- Mechanisms of Heme Transport in MacrophagesCARINE CARINE WHITE; Fiscal Year: 2012..Within the reticuloendothelial system, macrophages (M&s) play a major role in the recycling of heme-iron via phagocytosis of senescent red blood cells (i.e...
- The Role of Decidual Innate Immunity in the Pathogenesis of PreeclampsiaSe Te Joseph Huang; Fiscal Year: 2012..human cytotrophoblasts (CTBs) invade an underlying decidua comprised of decidual cells and such immune cells as macrophages (MFs) and dendritic cells (DCs)...
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2010..white and brown adipose tissues on early adipocyte progenitor cell (APC), in vivo adipogenesis, newly recruited macrophages in adipose tissues, mitochondria content, uncoupling protein (UCP)1 expression, monocyte migration, and ..
- Arginine Availability and Metabolism in the Immune Evasion of H. pyloriKeith T Wilson; Fiscal Year: 2013..We have shown that the regulator of L-Arg uptake in macrophages, cationic amino acid transporter-2 (CAT2), is required for protein expression of iNOS and that its function is ..
- Signaling by Cytoplasmic Tyrosine Kinases in LeukocytesClifford A Lowell; Fiscal Year: 2013..Deletion of SHP-1 in both neutrophils and macrophages (using LysM-Cre) results in no phenotype at all (despite the presence of activated neutrophils)...
- Tumor Microenvironment Interactions in Brain TumorsEric C Holland; Fiscal Year: 2010..The central hypothesis is that stromal cells, particularly macrophages and endothelial cells, provide key factors, such as matrix-degrading enzymes, which are co-opted by the tumor ..
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2013..IL-1[unreadable], prostaglandin E2, and matrix metalloproteinases (MMP) 1, 2, 3, and 9 release from macrophages and human gingival fibroblasts. Second, it blocks CR3-mediated internalization of P. gingivalis by macrophages...
- Role of Retroelements in Environmental AtherogenesisKenneth S Ramos; Fiscal Year: 2010..is a fibro-proliferative disease associated with endothelial injury, recruitment of inflammatory cells (macrophages and T cells), expansion of vascular smooth muscle cells (vSMCs) and buildup of cholesterol and extracellular ..
- Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA InterferenceAlexandra L Howell; Fiscal Year: 2013..b>Macrophages and dendritic cells (DC) in mucosal tissues express receptors that are triggered by viral proteins and nucleic ..
- Monocyte activation and the role of CD11c in obesity-linked metabolic syndromeHuaizhu Wu; Fiscal Year: 2013..CD11c is a b2 integrin primarily expressed on monocytes/macrophages and dendritic cells (DCs) that is a marker for monocyte/macrophage activation and participates in monocyte ..
- A2b Adenosine Receptor Regulation of Metabolic Disease and InflammationAnna Eisenstein; Fiscal Year: 2013..Ravid, a Biochemist and expert in vascular and adenosine biology, and Dr. Gokce, a Clinician Scientist with access to human samples and expertise in studying human adipose tissue. ..
- ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURYIrfan Rahman; Fiscal Year: 2013..We have found that SIRT1 levels are drastically reduced in response to CS exposure in macrophages, mouse lung, and in lungs of patients with COPD, and are associated with increased NF-(B activation and release ..
- Lipid Binding Proteins in Obesity and Diabetes SyndromesDavid A Bernlohr; Fiscal Year: 2013..proteins (FABPS) are intracellular free fatty acid receptors found expressed at high levels in adipocytes and macrophages. FABPs bind a variety of unesterified fatty acids and other lipid second messengers and mediate their ..
- EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETIONAnisa Shaker; Fiscal Year: 2012..of Chordin from colonic myofibroblasts and decreases secretion of Interleukin-6 (IL-6) from myofibroblasts and macrophages. We propose that these regulatory events are important because Chordin inhibits bone morphogenetic protein (Bmp)..
- The Role of Vascular MR-Regulated Genes in Vascular Function and DiseaseIris Z Jaffe; Fiscal Year: 2013..abstract_text> ..
- Novel Macrolide Th17 InhibitorsJay K Kolls; Fiscal Year: 2012..PUBLIC HEALTH RELEVANCE: Interleukin-17 can cause lung inflammation and asthma. This project is to indentify drugs that can inhibit IL-17 and lung inflammation. ..
- Characterizing TLR Function of Human Dendritic Cells in the ElderlyAlexander Panda; Fiscal Year: 2012..plans for establishing his independent research program, a pilot study of TLR function in lung-derived alveolar macrophages in bronchoalveolar lavage fluid from young and older individuals will be carried out to obtain pilot data...
- Regulation of NFkappaB activity by the Estrogen ReceptorKendall W Nettles; Fiscal Year: 2012..We propose to use these synthetic compounds to understand the molecular details of this important anti-inflammatory pathway. ..
- Role of the neurogenic inflammatory pathway in the genital tract immune responseRoger G Rank; Fiscal Year: 2010..Chemotactic factors produced as a result of substance P release recruit neutrophils, monocytes, macrophages, and lymphocytes to the local site...
- Regulation of vaccine-induced anti-fungal T17 cellsMARCEL WUETHRICH; Fiscal Year: 2013..Vaccine-induced T17 cells mediated protection by recruiting and activating neutrophils and alveolar macrophages to the alveolar space to augment fungal killing...
- Mechanisms of Angiogenesis in Retinopathy of PrematurityMary Elizabeth Hartnett; Fiscal Year: 2009..We will study the effects of EC- derived NADPH oxidase by depleting animals of macrophages. To change the degree of activation of NADPH oxidase, we will use the 50/10 OIR rescued in supplemental oxygen ..
- Hormonal regulation of a Ca2+/AMPK signaling pathwayAnthony R Means; Fiscal Year: 2013DESCRIPTION (provided by applicant): The overall objective is to define the Ca2+-signaling pathways in macrophages that regulate functions of and genes involved in the inflammatory response...
- Regulation of Astrocyte TIMP-1 in HIV-Associated DementiaJEREL ADAM FIELDS; Fiscal Year: 2011..The disease is characterized by an accumulation of activated and infected macrophages/microglia in the central nervous system, which secrete cytokines, infectious virions and viral proteins that ..
- The Role of Adipocyte-Induced Inflammation in Prostate Tumor ProgressionAIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2012..Ultimately, these studies should lead to identification of novel signaling pathways and molecular mechanisms predisposing prostate cells to metastasize to bone. ..
- Growth Hormone Regulation of SH2B1Christin Carter-Su; Fiscal Year: 2013..State-of-the-art microscopes, photoactivable probes, proteomics, cell lines and both primary macrophages and MEFs from SH2B1-/- mice, will also be used...
- Knockdown of Gene Expression in Immune Cells in Humanized MiceJudy Lieberman; Fiscal Year: 2010..aim is to test and optimize CD4- AsiCs for systemic knockdown of gene expression in CD4 T cells, monocytes and macrophages. We will also engineer similar CD8 aptamer-siRNA chimeras for gene knockdown in CD8 T cells and NK cells...
- Neuroprotection by IFN-beta in AIDSMarcus Kaul; Fiscal Year: 2013..neurodegeneration occurs as a consequence of HIV-1 infection and neurotoxic immune stimulation of microglia and macrophages (M?) in the brain and impairment of neurogenesis...
- Maternal Autoantibodies: Pathogenesis of Neonatal LupusJILL PAMELA BUYON; Fiscal Year: 2013..Understanding the mechanism by which these autoantibodies cause cardiac scarring is critical to the development of strategies for treatment or prevention of this condition, known as congenital heart block. ..
- Mechanisms of Angiogenesis of Retinopathy of PrematurityMARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2013..We will study the effects of EC-derived NADPH oxidase by depleting animals of macrophages. To change the degree of activation of NADPH oxidase, we will also use the 50/10 OIR model rescued in hyperoxia ..
- Colitis Induced by immune responses to luminal bacteria-mouseRyan B Sartor; Fiscal Year: 2012..epithelial cell adherence, invasion and resistance to intracellular killing within epithelial cells and macrophages, or 2) Genetically determined host innate defects in bacterial killing and mucosal barrier function...
- Deregulated lipid metabolism in strokeRobert J Dempsey; Fiscal Year: 2013..the cell cycle after stroke will provide benefit by attenuating neuronal death and proliferation of microglia/macrophages. Cell cycle regulation by lipid second messengers after stroke: Sphingomyelin (SM) synthase (SMS) transfers ..
- Impact of Diabetes and Hyperlipidemia on Host DefenseHardy Kornfeld; Fiscal Year: 2013..Diabetic mice are slow to develop aggregates of myeloid cells around Mtb-infected alveolar macrophages (AMF) and slow to deliver bacilli to the thoracic lymph nodes (TLN) where immunity is primed...
- Immune Development: Role of Milk Cell Transfer and Recipient GenderAmeae M Walker; Fiscal Year: 2013..Despite high numbers of GFP+ B cells and macrophages in milk, these cells were not observed undergoing trans-epithelial migration...
- Immune modulators of inflammation in servere COPDFarrah Kheradmand; Fiscal Year: 2010..We and others have shown that in addition to macrophages and neutrophils, lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, ..
- Lipid Binding Proteins in Obesity and Diabetes SyndromesDavid A Bernlohr; Fiscal Year: 2011..proteins (FABPS) are intracellular free fatty acid receptors found expressed at high levels in adipocytes and macrophages. FABPs bind a variety of unesterified fatty acids and other lipid second messengers and mediate their ..
- Hypertension and Collagen: Effect of Ac-SDKPNour Eddine Rhaleb; Fiscal Year: 2010..improve the affinity of the radio-iodinated peptide;and 2) characterize the Ac-SDKP receptor in fibroblasts and macrophages (rat and human), using [ l]-Hpp- Aca-SDKP and newly developed antagonists;and 3) compare rat cardiac ..
- DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosisRuslana Bryk; Fiscal Year: 2012..regulator by studying DlaT's expression under different conditions in vitro, in mouse bone marrow macrophages and in mice, by identifying proteins associating with DlaT under those conditions, by producing deletion and ..
- Mechanism of Irradiation Pulmonary FibrosisJoel S Greenberger; Fiscal Year: 2012..We have demonstrated that bone marrow origin macrophages migrate to the mouse lung at the time of up regulation of endothelial cell VCAM-1 and ICAM-1 at 120-140 days ..
- SRP RNA level as a determinant of leishmanial parasitism of macrophagesGautam Chaudhuri; Fiscal Year: 2009DESCRIPTION (provided by applicant): Leishmania is a group of parasitic protozoa that infect human macrophages and thrive inside the hostile environment of the phagolysosomes of these cells...
- A gene therapy for bacterial translocation in mice with whole body irradiationFujio Suzuki; Fiscal Year: 2010DESCRIPTION (provided by applicant): In studies of severely burned mice, IL-10(-) IL-12(+) macrophages (M1 macrophages) distributed in lamina propria (LP) and mesenteric lymph nodes (MLN) have been identified as major effector cells in ..
- THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSISWilliam Boisvert; Fiscal Year: 2002..in vitro is attenuated by several inflammatory mediators which can be in the plaque, or by differentiation to macrophages. They therefore propose that other mechanisms are at play in promoting macrophage retention and expansion ..
- M. tuberculosis survival in MacrophagesRichard Friedman; Fiscal Year: 2003..by the applicant): Central to the disease process in tuberculosis are the interactions of the bacilli with host macrophages. The infection of macrophages by Mycobacterium tuberculosis can be divided into four steps: adherence, entry, ..
- Role(s) of VEGF in Resolution of InflammationManuela M Martins Green; Fiscal Year: 2010..Upon wounding, cytokines are activated and chemoattract leukocytes, including macrophages, to the wound site...
- REGULATION OF THE TUMORICIDAL MACROPHAGE PHENOTYPEDavid Riches; Fiscal Year: 1991..As such, macrophage activation represents an important limb of the host defence system. Monocyte derived macrophages are initially primed by exposure to IFN alpha, beta, or gamma...
- Aveolar Macrophage Apoptosis and PneumocystisChao Hung Lee; Fiscal Year: 2009..The number of alveolar macrophages is decreased in humans with Pneumocystis pneumonia (Pep)...
- PERITONEAL MACROPHAGE MIGRATION IN ENDOMETRIOSISCECIL LYTTLE; Fiscal Year: 1993..indicated that the peritoneal fluid of women with endometriosis contains approximately ten times the number of macrophages as is seen in the disease free fertile patient...
- Novel GPCR Kinase Interactions in Macrophages and Role in ArthritisNarayanan Parameswaran; Fiscal Year: 2009Monocytes/macrophages are crucial cell types in inflammatory processes in many diseases including musculoskeletal diseases...
- GM-CSF is required for macrophage surfactant catabolismTracey Bonfield; Fiscal Year: 2006..in the alveoli of surfactant material, which is thought to result from inefficient catabolism by alveolar macrophages and type II epithelial cells...
- IL15 AND NATURAL KILLER (NK) CELL FUNCTIONWilliam Carson; Fiscal Year: 1999We hypothesize that macrophages are able to influence the function of natural killer (NK) cells via a novel cytokine known as IL-15...
- DECIDUAL CELL/PLACENTAL INTERACTIONSJOAN HUNT; Fiscal Year: 1993..Among the major cell types that expand in response to pregnancy are macrophages, cells with both primitive and highly sophisticated functions...


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firstname.lastname@example.com | 07875 074 899
Creative Wedding Stationery Studio
A floral vintage design that is loved so much, even our Creative Director Amy Manning used it for her wedding, hence the name. We also have a pretty, delicate version available.
Programme of Events Size: A2 (420 x 594mm) (single side print)
Paper: Foam Board


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video from NDTV
Duration : 0:7:0
video from NDTV
Duration : 0:7:0
For the latest on Bollywood like zoOm on http://www.facebook.com/zoomtv & follow us on http://www.twitter.com/zoOm_buzz and visit http://www.zoomtv.in
Your one-stop-shop to lastest, hottest Bollywood news, gossip and gupshup.
Duration : 0:1:36
The bar for marketing films is set to go up by many notches as Shah Rukh collaborates with Google and YouTube to promote Ra.One, making it the first Bollywood film to do so. In an exclusive interview with NDTV, SRK talks about novel promotion tactics, KKR's erratic performances and what he feels about being Shoaib Akhtar's brother!
Duration : 0:2:37


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Product Reviews
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Dominic Coppola/Fred Thomas: split tour tape (Life Like, 2016)August 12, 2016 at 9:17 pm | Posted in Reviews | Leave a comment
Very limited tour tape which seems to end before it begins. Dominic Coppola has graced several shows in houses and small venues here in Michigan, and his presence is always very welcome. His track here is called "Clarice", and it's very simple and lovely. It seems to slowly drift from one note to another, and there's no reason for it to do anything more than what it does. The Fred Thomas side is a song called "House Show, Late December", and by the title I was expecting a recording of a very short noise set or something, as he's posted things like that on Soundcloud before. Instead, this is a song about a noise show at a house, and getting through a tough year. It's a little similar lyrically to the most recent FT solo album, but the music is kind of an urgent guitar ambient cloud which slowly gets filled with more abrasive noise as the poetic lyrics keep coming. It's incredibly powerful. Might still be a few copies left at Life Like.
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Preston North End manager Simon Grayson was delighted a frustrating week away from the pitch was rounded off by a battling display on it which secured victory over Yeovil.
Goals from Paul Huntington and Paul Gallagher gave PNE a 2-0 win against the Glovers at Huish Park, a result which kept them on the heels of top two Bristol City and Swindon.
Last week, Grayson lost the services of Joe Garner and Callum Robinson, while enduring a slightly frustrating time in the run-up to the close of the loan window.
Although he did secure the services of Middlesbrough striker Bradley Fewster – who was on the bench against Yeovil – other targets slipped through the net.
Grayson said: "We have won two tough league games and a cup tie in the space of a week, the players have done well and got themselves ready to go again after each match.
"There were quite a few people negative and down after we lost Joe Garner and Callum Robisnon but we have done the business on the pitch.
"Now what we want to do is build on this. We have an FA Cup tie coming up next which we want to win.
"We knew that Yeovil would be a tough game for us – their position in the league does not really reflect how they have played over the last few weeks.
"What was important was that we were mentally and physically right for it, Yeovil pop the ball around well and we had to stay as focused as we were at Bristol City the week before.
"We got off to a terrific start with Paul Huntington's goal and went on to limit Yeovil to very few opportunities.
"It was good to see the second goal go in when it did because it killed the game off.
"There were aspects of our play which we know we need to do a bit better but I can't knock the players for rounding off a tough week with a win."
Huntington's fifth-minute header from a Gallagher corner, came against his former club.
The scoreline remained that way until the 90th minute when Gallagher ran clear on to a Kevin Davies pass to chip the second goal.
For the last 26 minutes, PNE played against 10 men after Glovers centre-half Ryan Inniss was shown a straight red card for a sliding challenge on Kyel Reid.
Reflecting on the key points of the contest, Grayson said: "For the red card, their lad slid in and caught Reidy.
"I don't know how much of the ball he got too but in this day and age you leave yourself vulnerable if you slide in for tackles.
"It's hard for me to comment on whether it was a red card or not – the decision was made by the referee.
"The goals that we scored pleased me. When you looked at their team, you thought they would be a real threat because of the size and presence of some of their players.
"I thought we were a little bit weak in that department so for us to score from a set-piece was very pleasing.
"The second goal finished the game off nicely. It was a good ball from Kevin Davies and Gally finished it well.
"We have a clear midweek now to get some more work done in training."