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Talented people's time in our society is primarily engaged with money. As a result we are doubling the staff of DownloadSquad and we've increased the rate we are paying our bloggers to $10 a post on that blog (much more for features). As a result I'm sure our traffic will double over the next three months--in fact I will guarantee that it will happen. Money does change everything.Talent wins, and talent needs to get paid. I love paying talented people so they can sleep well at night doing what they love. That's my biggest joy in business: gettin' people paid.Before launching the new Netscape I realized that Reddit, NewsVine, Delicious, and DIGG were all driven by a small number of highly-active users. I wrote a blog post about what drives these folks to do an hour to three hours a day of work for these sites which are not paying them for their time. In other words, they are volunteering their services. The response most of these folks gave back to me were that they enjoyed sharing the links they found and that they got satisfaction out of being an "expert" or "leader" in their communities....We will pay you $1,000 a month for your "social bookmarking" rights. Put in at least 150 stories a month and we'll give you $12,000 a year. (note: most of these folks put in 250-400 stories a month, so that 150 baseline is just that--a baseline)..Now, this offer is going to get a big response I know, so we're going to have to limit to a dozen or so folks. ...
Among the top diggers are people who have submitted over 1000 stories to digg, with a 25-40% success rate in getting those submissions to the digg homepage! If you do some back-of-the-envelope calculations, you quickly see that paying those top diggers $1000 per month is a pittence for what Netscape will reap - hundreds of thousands of extra pageviews per month, maybe millions.
There is the question of whether or not this will fix this. Digg's Achilles heel is that such a small group of active users drives so much of their success. However, even if those users bail to Netscape, others will certainly take their place at Digg. In my opinion, Netscape may gain some human assets and may get better story submissions, but Digg will probably continue to thrive.
At the end of the day, the Netscape product is a soulless reproduction of one of the most interesting cultural experiments occuring on the web right now. It was thrown at millions of mainstream Internet users (previous Netscape portal users) who don't understand Digg and probably don't care (yet). If anything, my bet is that total page views at Netscape have dropped since the changeover, possibly substantially. Buying users from Digg won't change that one bit.
This offer is open to about a dozen people initially. You've got to hand it to Calacanis, he is a very savvy businessman and this offer will really stir the 'community news' pot. The cynic in me says he's decided to do some 'offensive defence', to try and put the New Netscape troubles behind him. And money talks.But put this into context of my post yesterday about Digg's stats, where I noted that a select group of digg users are highly influential, and it makes perfect business sense. Among the top diggers are people who have submitted over 1000 stories to digg, with a 25-40% success rate in getting those submissions to the digg homepage! If you do some back-of-the-envelope calculations, you quickly see that paying those top diggers $1000 per month is a pittence for what Netscape will reap - hundreds of thousands of extra pageviews per month, maybe millions. This will come from increased quantity of stories, as well as the 'quality' that Jason talks about at length in his post (unfortunately quantity still rules on the Web though).
donationcoder is not going to be paying posters $1000 per month
"In what is either an act of desperation or genius (only time will tell), Netscape's new leader Jason Calacanis is offering the top users of Digg (those who post more than 150 links a month and drive most of its traffic) $1,000 a month to switch to Netscape.."
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text:
WASHINGTON — In a closed-door meeting on Wednesday, House Majority Leader Eric Cantor (R-Va.) listed the beliefs he said united Republicans, urging them not to "confuse tactics with principles."
"The differences between us are dwarfed by the differences we have with the Democratic Party," he declared.
But in the Capitol's halls, as bruised and defeated Republicans discussed what had befallen them, those internal divisions seemed only to widen.
"It's pretty hard when we have a circle of 20 people who stand up every day and say, 'Can we surrender today, Mr. Speaker?'" said Rep. Tim Huelskamp (R-Kan.), referring to moderate Republicans in the House.
Rep. Charlie Dent (R-Pa.), one of those centrists, countered that he was merely a "truth teller."
"Some people have a hard time when others state the obvious," he said, noting that Republicans cannot enact major legislation without support from Democrats, who control the Senate. "We might as well accept that reality and deal with it."
The 16-day government shutdown drew to a close Wednesday night as the House prepared to approve a Senate-passed budget compromise. But even as Congress was ending the shutdown and averting the prospect of the government defaulting on its debts, the volume of political recriminations was growing.
Republicans had initiated the confrontation last month hoping to block or delay President Obama's healthcare law. Having failed in that effort and with their internal divisions vividly exposed, they spent Wednesday in a furious round of finger-pointing in both chambers.
"Everybody is frustrated. We got to put Humpty Dumpty back together again," said Rep. Fred Upton (R-Mich.).
House Speaker John A. Boehner (R-Ohio), who has been unable to unite his troops, did not appear in danger of losing his post, in part because no challenger has stepped forward to try to take the job.
But relations between the party's moderates and tea party conservatives are raw. Both sides — but particularly tea party conservatives and advocacy groups — have threatened to try to stage primary challenges to unseat incumbents.
"If anybody should be kicked out, it probably is those Republicans — and not Speaker Boehner — who are unwilling to keep the promises that they made to the American people," said Rep. Raul Labrador (R-Idaho), a leader of the House's ardent conservatives, many of them recently elected.
Many conservatives, such as Rep. Matt Salmon (R-Ariz.), a veteran of the last government shutdown who returned to Congress this year, seemed satisfied with Boehner's leadership.
"I think he personally did a phenomenal job trying to deal with very disparate feelings and emotions and ideas and opinions," he said. "While I may still have disagreements with him, he's earned my respect."
Some moderates, by contrast, said they were increasingly unhappy with the leadership's willingness to placate the party's right wing.
"I felt like I needed to give my leaders the flexibility that they were asking for," said Rep. Aaron Schock (R-Ill.), calling himself part of a silent majority in the GOP ranks. "I'm going to be less likely to give them that flexibility … if we're going to go along with some of these tactics that I don't think are going to be successful."
In the Senate, Republicans who wrested control of the budget fight from the House to reach a bipartisan compromise expressed frustration that their House colleagues had picked a fight over Obamacare that they could not win. They worried conservatives might do the same all over again.
"We've been saying from the beginning, 'What is the endgame? How does this end? How do you achieve what you are purporting to achieve on defunding Obamacare?'" Sen. Kelly Ayotte (R-N.H.) said.
"If they are saying that the defunding issue is going to come up again in three months, then they have learned nothing from this."
The animosity stirred up by the intraparty conflict over the anti-Obamacare strategy led by tea party Sen. Ted Cruz (R-Texas) broke out in the form of speeches on the Senate floor.
"I think it's obvious that we are now seeing the end of this agonizing odyssey that this body has been put through," Sen. John McCain (R-Ariz.) said in one floor speech. "It's one of the more shameful chapters that I have seen in the years that I have spent here in the Senate."
Cruz choose to denounce the bill ending the shutdown at the same time his party's Senate leader, Mitch McConnell (R-Ky.), joined Senate Majority Leader Harry Reid (D-Nev.) on the Senate floor to announce it.
Cruz later used his final speech before the Senate's vote on the Reid-McConnell compromise to criticize fellow Republican senators for not having supported the anti-Obamacare effort more strongly.
"If all 46 Senate Republicans had stood together and simply supported House Republicans" in their votes to block the healthcare bill, "this result, I believe would have been very, very different," he said.
Meanwhile, McConnell's opponent in a GOP primary next May , Matt Bevin, sought to use the moment for his political advantage.
"When the stakes are highest, Mitch McConnell can always be counted on to sell out conservatives," he said in a statement. "McConnell just negotiated the GOP surrender."
The shutdown, which polls show Americans blamed on Republicans, appears to have widened the rift between moderates and conservatives not only in Washington, but throughout the country.
A new Pew Research Center poll showed that among those identifying themselves as moderate Republicans, views of the tea party movement have soured, dropping from 46% favorable in June to just 27% this month.
Within the GOP, the tea party is seen as an independent political movement. Among those who identify with the tea party, just 41% say it is part of the Republican Party, while 52% see it as "separate and independent." Just more than one-quarter of non-tea-party Republicans see the movement as part of the GOP.
That dynamic could manifest itself soon, as lawmakers face the first round of primary elections next March.
The most powerful conservative advocacy groups —Heritage Action and the Club For Growth — on Wednesday urged Republicans to vote against the compromise plan and warned that the vote would be a factor in whether they support incumbent Republicans or back challenges from more conservative opponents.
House leaders have been repeatedly thwarted when those groups lobby against them.
Salmon, however, said the party would be able to unite again — "because we have to."
"When all sides see that you're actually willing to stand and fight on principle, it changes the dynamics.," he said. "It's not evident right now but I think it will be."

subset: commoncrawl


text:
Sept. 25 is a Tuesday, which is one of the preferred days for patching and other fun. The release date is a bit later than many expected, but Blizzard operates under the philosophy of "it's done when it's done," so a later date only means we're getting a product that's been through a lot of testing.
You can upgrade to the standard edition and digital deluxe edition through your Battle.net account page now.
Update 9:30 p.m. EDT: Added the official press release announcing the release date. You can view it after the break.


text:
Follow RFF News on your cell phone. Text follow rff to 40404 you will receive txt messages with RFF News
0 Members and 1 Guest are viewing this topic.
Yaxha is visiting Nakum to,,, (44 Minutes of Fame) ...beg for food/water ...club Judd to death ...find/steal immunity ...get directions home ...just say hi ...listen to Stephenie whine ...merge with them ...raid the camp Something not listed here
Darn saw your message this morning!! Oh well!! And I thought maybe Gary would stick with Amy but no! So I missed that one too. Jaime should get bad points for being a pary pooper.
Rafe should get points for making a deck of cards from leaves!
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text: The focus of the Digital Media Arts certificates to prepare students for graphic design jobs for print and web. We have two state-of-the arts labs, located at Santa Ana College main campus and at the Digital Media Center. Labs are equipped with iMacs, printers (laser and ink jet) large format, scanners and Remote Desktop. Successful students have won awards at the state level in multi-media competitions, the Orange County Fair and have their work in exhibits in galleries and businesses in the Santa Ana Community.


text:
Developing Biomarkers of Dietary Intake
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01237093
Recruitment Status : Recruiting
First Posted : November 9, 2010
Last Update Posted : December 4, 2018
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
- Researchers who study health and nutrition are interested in developing more accurate methods of determining what people eat from day to day and how it affects their general health. In particular, better methods are needed to determine if people are accurately remembering what they ate. One possible method involves the use of biomarkers, or indicators in urine, blood, saliva, fat, and hair, which are related to the intake of a particular food in a consistent way. One set of biomarkers in blood samples and hair may be used to determine the relative amount of meat, fish, and soda (corn/sugar cane) in a person s diet. However, more research is needed to study the effectiveness of using these biomarkers to accurately track dietary intake.
- To validate the use of biomarkers as representative of specific dietary intake patterns (meat/fish/soda).
- Healthy, nondiabetic men between 18 and 65 years of age.
- This study involves an initial screening visit and a 12-13 week inpatient dietary study period.
- Participants will be screened with a medical history and physical examination, as well as blood and urine samples and a glucose tolerance test to exclude individuals who have diabetes.
- After 3 days of a standard weight-maintaining diet, participants will have a glucose tolerance test and a body fat scan; provide hair, blood, and fat tissue samples; and complete questionnaires and performance tests.
- Participants will spend one day in a metabolic chamber to measure their energy expenditure and general metabolism.
- Participants will then be randomized into one of eight carefully designed diets for 12 weeks. The diets will differ in the amount of meat, fish, and soda, including one diet where none of the three biomarker-related foods will be permitted. Blood samples will be collected throughout the study diet period.
- At the end of the 12-week study diet period, participants will provide additional hair, blood, and fat tissue samples, and will have a second metabolism assessment in the metabolic chamber....
|Condition or disease
|Diet Therapy Healthy
Studies of health and nutrition use a variety of tools to determine what people eat from day to day. Unfortunately, most of the methods used are not accurate for a variety of reasons and do not provide solid information on which to base health recommendations or public policy. In general, when people are asked to keep track of what they eat or recall what they have eaten in the past, they make mistakes in estimating both amounts and specifics of what was eaten. New tools that can help determine if people are accurately remembering what they ate are desperately needed.
Biomarkers are things that can be measured (in urine, blood, hair, etc.) which are related to the intake of a particular food in a consistent way and may therefore be more accurate than a food record. One set of biomarkers that may be used are naturally occurring (present in all foods) stable isotopes of carbon and nitrogen to determine the relative amount of meat, fish, and soda (corn/sugar cane) in a person s diet. These isotopes can be measured in blood samples and hair.
The aim of this study is to validate the use of stable isotope biomarkers as representative of specific dietary intake patterns (meat/fish/soda). This study will be an inpatient study in which highly specific diets will be fed to volunteers for ~12 weeks and stable isotopes will be measured in blood and hair. The ultimate goal is to develop biomarkers to be used to validate food intake patterns in outpatient clinical and epidemiological studies.
|Study Type :
|Estimated Enrollment :
|120 participants
|Observational Model:
|Ecologic or Community
|Time Perspective:
|Official Title:
|Developing Biomarkers of Dietary Intake
|Study Start Date :
|October 24, 2010
- N isotope ratio fish vs. no fish diet [ Time Frame: 4 years ]
- C isotope ratio meat vs. no meat diet [ Time Frame: 4 years ]
- Elevations in C isotope ratios by diet [ Time Frame: 4 years ]
- Improved psych-behavioral questionnaires [ Time Frame: 4 years ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Body mass index less than or equal to 35 kg/m(2) to minimize the impact of body size on isotope measurements.
- Males 18-65 years old will be recruited for this study. Minors under the age of 18 will be excluded because the time requirements of the study are such that they would interfere with school schedules.
Healthy, as determined by medical history, physical examination, and laboratory tests.
- Current smoking
- Female sex
- Baldness or hair less than 2 cm in length
- Medically- or self-imposed dietary restrictions that would limit a participant s ability/willingness to consume the diet to which they are randomized.
- Type 2 diabetes (according to the World Health Organization diagnostic criteria)
- Endocrine disorders (Cushing s Disease, pituitary disorders, and hypo- and hyperthyroidism)
- Chronic pulmonary disorders, including chronic obstructive pulmonary disease, that would limit ability to follow the protocol (investigator judgment) and obstructive sleep apnea syndrome; only subjects with mild or exercise-induced asthma on no medications or on beta-adrenergic agonists only (such as albuterol) will be allowed to enter the study (provided use of these agents is not required for one week before study entry).
- Cardiovascular diseases (coronary heart disease, heart failure, arrhythmias, and peripheral artery disease)
- Hypertension (blood pressure measurement higher than 140/90 mm Hg on two or more occasions or use of anti-hypertensive medications)
- Diagnosed gastrointestinal diseases, including inflammatory bowel diseases (e.g., Crohn s disease and ulcerative colitis), malabsorption syndromes (e.g., celiac disease), gastric ulcer (active); only subjects with gastro-esophageal reflux will be allowed to enter the study
- Presence of a pacemaker or other implantable devices
- Liver disease (cirrhosis, active hepatitis B or C, and AST or ALT greater than or equal to 1.5 x normal)
- Renal disease (serum creatinine concentrations greater than or equal to 1.5 mg/dl and/or greater than 100mg/dl of protein based on urine dipstick)
- Central nervous system disease (cerebrovascular accidents, dementia, and neurodegenerative disorders)
- Cancer requiring treatment in the past five years, except for non-melanoma skin cancers or cancers that have clearly been cured or in the opinion of the investigator carry an excellent prognosis
- Alcohol (more than 3 drinks per day) and/or drug abuse (such as amphetamines, cocaine, heroin, or marijuana)
- Current or past history of: bipolar disorder, schizophrenia or presence of psychotic symptoms, bulimia nervosa or anorexia nervosa, or current major depressive disorder
- Weight change of plus or minus 5% in the last 3 months
Conditions not specifically mentioned above may serve as criteria for exclusion at the discretion of the investigators. Additionally, potential subjects might be excluded if they demonstrate a style of interpersonal relationships that would inhibit successful completion of the study.
Non-English speaking subjects as a population will be excluded from participation in this protocol. One of the secondary hypotheses of the protocol relates to a battery of psychological questionnaires and performances tests which are administered to the volunteers at the beginning and end of the study. There are currently no validated, translated forms of these questionnaires and tests available; therefore we will restrict enrollment to English speaking subjects only.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01237093
|Contact: Susanne Votruba, Ph.D.
|(602) 200-5336
|United States, Arizona
|NIDDK, Phoenix
|Phoenix, Arizona, United States, 85014
|Contact: Susanne Votruba, Ph.D. 602-200-5336 email@example.com
|Principal Investigator:
|Susanne Votruba, Ph.D.
|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|Responsible Party:
|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|ClinicalTrials.gov Identifier:
|NCT01237093 History of Changes
|Other Study ID Numbers:
|First Posted:
|November 9, 2010 Key Record Dates
|Last Update Posted:
|December 4, 2018
|Last Verified:
|April 20, 2018
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ):
Fish Diet
Meat Diet
Stable Isotopes
Dietary Intake


text:
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The Original 5 Mics - Hungriest N*gga Alive (StreetHeat Artist) [StreetHeat Submitted]
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19-Year-Old Thug Who Forced Boy To Strip & Then Being Beaten With A Belt Over $20 Arrested!
"Police in Newark, NJ arrested three people on Tuesday in connection with a video of a savage beating of a teenage boy. According to the New York Daily News, police acted after the video of the brutal attack went viral, racking up tens of thousands of views. In the video, the victim can be seen being ordered to strip off his clothes before another man attacks him with a belt, beating him ruthlessly for more than two minutes as the victim cowers and cries out in pain."
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text:
Observation Fusion: Earth Observation Coverages
OWS-8 Earth Observation Coverages
Raj Singh, Ph.D.
The Sensor Web Enablement (SWE) architecture was designed to enable web-accessible sensor assets through common interfaces and encodings. Sensor assets may include the sensors themselves, observation archives, simulations, and observation processing algorithms. The Observation Fusion thread continues the further refinement and extension of SWE with an emphasis on sensor fusion.
In 2010, OGC approved the OGC Web Coverage Service (WCS) Interface Standard, Version 2.0. The WCS 2.0 has several significant enhancements over previous versions. WCS 2.0 is harmonized with the Geography Markup Language (GML) coverage model, leading to increased interoperability across OGC standards. It supports the following encodings: GeoTIFF, HDF, NetCDF, and JPEG2000. WCS 2.0 brought together, for this testbed, the resources of both U.S. and European space agencies (NASA, ESA) to help develop a common profile for best interoperability.
Development had already begun for an Earth Observation Application Profile (WCS 2.0 EO-AP) before this testbed. Since the release of the WCS 2.0 suite of documents, a WCS 2.0 EO-AP has been drafted in ESA's HMA project. The EO-AP builds on previous work with WCS 1.0. The EO-AP draft includes NetCDF , GeoTiff or JPEG2000 as possible return formats. The EO-AP draft was further developed in OWS-8 to include compliance testing with multiple datasets and will be coordinated with development of a Compliance Test Suite.
EO Coverages Objectives
- Goal: Make Web Coverage Service (WCS) better for Earth Observation Scientists
- - Develop EO Profile of WCS (EO-WCS)
- - Implement EO-WCS (stimulate broadest uptake by software developers and users)
- - Compliance Tests for EO-WCS
- Use EO-WCS in Imagery Processing
- - Web Coverage Processing Service
- - Web Processing Service
OWS-8 EO Coverages Engineering Reports
These Engineering Reports are publicly available, see the Deliverables Page of this website. Most component deliverables are prototypes, not available for commercial use. These will all be maintained for at least a few months after the testbed. Contact the relevant participant organization or OGC staff if questions.
|OGC Doc#
|Document Title
|OWS-8 Geoprocessing of Earth Observations
|Jacobs University
|OWS-8 WCS 2.0 Earth Observation Application Profile
|Jacobs University
|OWS-8 WCS 2.0 Earth Observation Application Profile Compliance Tests and Reference Implementation
|Jacobs University
|OWS-8 Engineering Report Metadata Mapping between NASA ECS/HDF-EOS and WSC 2.0
EO Coverages Results
- New for WCS: Time series processing
- Interoperability demonstration for WCPS/WPS
- Homogeneous access to 2D, 3D, 4D, 5D datasets
- Future work
- - Incorporate findings into tasks for WCS 2.1 spec development
- - Bring new specifications to adoption:
- CRS handling
- Improved format encodings (HDF, NetCDF, JPEG2000)
WCS 2.0 Conformance Testing
- Completed modular testing framework for WCS 2.0 suite.
- Have 3 independent implementations of WCS 2.0 services (rasdaman, MapServer, GMU) that have passed the tests.
- OGC can now offer WCS conformance branding to vendors
- Future work:
- - Several format encodings and CRS handling are being added to WCS->These will need abstract test suites (assertions) and executable test suites (scripts)
- - Maintenance of testbed
EO Coverages Scenario: State of Emergency in Brazil due to Amazon basin droughts
On the heels of the once-in-a-century drought in 2005 comes an even more severe drought in 2010, which also was intense and coincided with the dry season. Direct evidence of the impact in terms of the spatial extent and severity of the 2010 drought on Amazonian vegetation is currently lacking. Hence, NASA is interested in developing methods to automate drought analysis using commonly available satellite datasets of precipitation and vegetation greenness. Furthermore, NASA's interest in the OGC Web Coverage Service protocol reflects the desire to make data characteristics, such as granularity, projection, and formats, more transparent in order to accommodate diverse communities wishing to fully exploit NASA's vast data archives for new applications that require data transformations.
NASA satellite sensors, such as MODIS, showed an average pattern of greenness of vegetation on South America: Amazon forests which have very high leaf area are shown in red and purple colors, the adjacent cerrado (savannas) which have lower leaf area are shown in shades of green, and the coastal deserts are shown in yellow colors. (Credit: Boston University/NASA)
Coverages Demo 3: Amazon basin drought analysis using WPS
- Satellite data can go through two stages of analysis. First, pre-processing occurs to filter out cloud cover, correct for aerosol-corruption effects, and to remove residual atmosphere-corruption to produce the best possible signals from the vegetation. In OWS-8, participants took data from NASA and ESA and applied these pre-processing steps before serving the imagery via EO-WCS.
- This allowed the imagery to be available in a very flexible manner, including the capability to mosaick, re-project and warp adjacent satellite images to match the coordinate reference systems of other datasets. Only then can any actual analysis occur. And in a moment you will see mathematical functions applied to the imagery to study drought, identifying the change in precipitation and greeness over time.
- Analysis was performed in desktop software, a web processing service (WCS), and a web coverage processing service (WCPS).
Coverages Demo 5: Oil spill image analysis using WCPS
News Flash: Earthquake hits Monterey California! Oil well in Monterey Bay is destroyed!
Earth Observation Web Coverage Service re-purposed for emergency situational awareness.
While the drought analysis used Earth Observation Web Coverage Services as data input, which is at it's core a standard OGC Web Coverage Service, the data sets can be re-used in completely different domains as a standard WCS – there's no need for others to know these data are also being exploited through Earth Observation systems.
We now move to a disaster and emergency response scenario, where these services join with a host of others to help emergency management teams respond to an earthquake.


text:
Remember "Antennagate?" A year and a half after Gizmodo first reported reception problems with iPhone 4, a class action lawsuit against Apple has finally come to a settlement. According to CNet, iPhone 4 owners in the US will soon be entitled to $15, or a $30 iPhone bumper case.
"This settlement relates to a small number of customers who indicated that they experienced antenna or reception issues with their iPhone 4, and didn't want to take advantage of a free case from Apple when it was being offered in 2010," an Apple spokesperson told CNet.
Back in June of last year, iPhone 4 owners complained that the simple act of holding the phone with your bare hands on the bottom-left corner caused the phone's reception to suddenly decrease, or drop altogether. The problem could be solved by simply using a "bumper," or other type of case that covered the sides of the phone. Surprisingly, after Gizmodo suggested that Apple "start handing out bumpers pro-bono to those who are experiencing problems," Apple did just that, offering a free case, or a full refund for the device within 30 days after purchase.
The class action lawsuit, filed with the North District Court of California, named five perpetrations, including unfair competition, false and misleading advertising, breach of warranty, breach of Song-Beverly Consumer Warranty Act (a law that requires the manufacturer to replace or refund consumers' money if it is unable to repair the defective product), and a violation of the Consumer Legal Remedies Act, which is intended to prevent deceptive actions to sell a product.
The suit against Apple claims that owners were mislead, stating, "At all pertinent times, Defendant represented to the public, including Class members, that the iPhone 4 was a dependable and reliable mobile device; that they were free from defects; and that they were of merchant quality and workmanship."
The result of the settlement requires Apple to inform customers that they are entitled to a $15 check, or a bumper case, by April 30, 2012. Customers who refused the free bumper, or refund in 2010 may still take advantage of the settlement. Those who already accepted Apple's offer are ineligible to receive the check, or a second bumper.


text:
The Darden School offers an intellectually demanding doctoral
program for a small, select group of high-potential applicants: men and women
who already have a breadth of knowledge in the functional areas of business
and who have a strong interest in teaching and research.
The program aims to be distinctive, not only by providing sound
training in the theory and methodology of the students chosen field, but
also by training students to perform applied research. Graduates of the program
are expected to be able to conduct rigorous research that contributes to the
solution of management problems in a creative and original fashion. The program
provides exposure to a variety of pedagogies, particularly interactive approaches
that allow students to take an active role in the learning process.
A doctoral student must specialize in a major field of study.
The school has major fields in finance, marketing, operations management, and
management. The management major field is composed of four subfields: strategic
management, business ethics, general management, and entrepreneurship. Only
a subset of these major fields admit students in any given year.
Acceptance of an applicant as a student in the doctoral program
is based on the following criteria:
Application forms may be requested from:
Director of the Doctoral Program
Darden Graduate School of Business Administration
University of Virginia
P.O. Box 6550
Charlottesville, VA 22906-6550
(434) 924-7247
Applicants are required to take the Graduate Management Admissions
Test given by the Educational Testing Service of Princeton, NJ. Those who have
already taken this test should request the Educational Testing Service to forward
their test results or should submit a true copy of the scores to the director
of the doctoral program.
Foreign applicants must also take the TOEFL (Test of English
as a Foreign Language) examination in order to be considered for admission.
Applicants seeking further information regarding the program
and admission may write to the director of the doctoral program.
The administration of the doctoral program has been assigned
by the Darden School faculty to the Doctoral Operating Committee, a standing
committee of the faculty. Each major field of doctoral study established by
the faculty has a major field advisor who is a member of the doctoral committee.
The general administration of the doctoral program is the responsibility of
the director of the doctoral program.
A students entire financial requirements will not ordinarily
be underwritten by the school. Nevertheless, the faculty hopes that no qualified
applicant will be unable to enter the doctoral program because of lack of financial
A student with outstanding potential and/or who demonstrates
that outside sources are not available may apply for a fellowship for tuition,
fees, and living costs. Generous fellowship awards may be received for the two
years of full-time course work and for the one year of full-time dissertation
research. Recipients must be in good academic standing to qualify for fellowship
stipends. The director of the doctoral program will review the academic performance
and the financial support needs of each student every 12 months. If a students
financial support needs have changed, revisions in the fellowship stipend will
be made. In addition, loans are available. Tuition waivers and part-time teaching
and research assistantships are often available to those students needing and
desiring them. During the summer, research assistantships are available.
The degree requirements outlined below apply to all doctoral
students. The particular program of study designed to enable a student to fulfill
these degree requirements depends on the students previous experience
and education. An individual program of study is structured in close consultation
with the student to permit completion of the degree requirements in the most
efficient manner. In general, the development of competence within a major field
involves doctoral seminars and course work in second-year M.B.A. elective courses
and individual reading under the supervision of a member of the major field
faculty. Courses in research methods and supportive discipline-based work are
usually taken in either the Graduate School of Arts and Sciences or in the School
of Graduate Engineering and Applied Science.
The overall time period actually required to satisfy doctoral
program requirements varies depending upon the students previous education
and experience, the work load and performance, and the nature of the dissertation
Breadth Requirements A student must demonstrate mastery
of the basic functions and disciplines of business administration determined
to be most related to the students major field.
Required Course Work in Quantitative Methods, Economics,
and Other Relevant Disciplines Each field requires advanced-level training
in relevant quantitative techniques, economics, and behavioral sciences. This
requirement is typically met by satisfactorily completing graduate courses in
the Graduate School of Arts and Sciences. The specific types and amounts of
courses depend on the major field.
Required Courses for All Doctoral Students All doctoral
students must complete doctoral-level courses in research methodology and pedagogy.
Part of these requirements may be satisfied by research and teaching internship
Major Field Professional Requirements Each field requires
the doctoral student to complete two to four advanced professional courses.
This requirement is designed to involve each student in current issues and problems
at an advanced level in her or his chosen field.
Major Field Theory and Literature Students in each major
field must complete a group of doctoral seminars in order to broaden and deepen
their understanding of the significant literature and theory of their chosen
field. For example:
Operations Management:
Major Field Research Paper Under the guidance of a faculty
member, each student develops an intensive field- or library-based study of
a significant problem in the students major field. Each student is expected
to demonstrate independent research abilities, including selection of a research
question, selection of research methodology, analyses of appropriate literature
and data, and presentation of a written report on the research findings.
Major Field Examination This examination is normally
taken by the end of the students second year of full-time work. Administered
by a committee that draws some of its members from outside the Darden School
faculty, the examination is primarily concerned with a students knowledge
of the substantive content of the major field, as defined by her or his general
program of study. Each student should demonstrate doctoral-level skills and
knowledge concerning the fields fundamental problems, theories, and conceptual
frameworks, and should show a well-developed capacity to reason logically, orally,
and in writing. Each student should also demonstrate in-depth competence within
an area of specialization in the major field.
Dissertation Research Proposal Each student is required
to prepare a dissertation research proposal and to pass a proposal examination
before conducting research and writing the dissertation. The purpose of the
proposal and examination is to obtain assurance, from the viewpoint of both
the faculty and the student, that the research project is worthwhile and feasible.
Dissertation Each student is required to present an
acceptable dissertation based on an approved proposal. A reading committee,
of which the dissertation supervisor is normally chair, will determine whether
a dissertation is acceptable. The dissertation must contribute to knowledge
in the field and the resolution of a significant management problem. Each student
is expected to present a public oral defense of the dissertation as part of
the requirements for the doctoral degree.
Residence Requirements and Program Length University
requirements for the doctoral degree are two continuous academic semesters of
full-time graduate study (or the equivalent) in residence toward the doctoral
degree, not including previous semesters in residence at the University of Virginia
for the purpose of obtaining another degree. Experience suggests, however, that
a minimum two years of full-time work in residence is usually needed to complete
the formal requirements of the degree.
Breadth Requirements The failure of a student to meet
the breadth requirements within three years shall be considered unsatisfactory
academic progress and shall terminate the students enrollment in the program.
Course Requirements No course at the Darden School in
which the students grade is not at least B shall be counted toward the
completion of the major field course requirements. Courses taken in other schools
to fulfill degree requirements shall be counted for this purpose only if the
student receives at least the minimum grade acceptable for credit toward a graduate
degree in the schools within which the courses are taken. A student whose work
in a major field course fails to meet these standards, and whose work is otherwise
satisfactory, may arrange for remedial work with the course instructor or may
take another course; any student whose work in more than two major field courses
has not been acceptable shall have failed to meet the academic standards of
the doctoral program.
Major Field Examination A student who fails the major
field examination shall have failed to meet the academic standards of the doctoral
Dissertation Proposal Examination A student is ordinarily
expected to pass the initial dissertation research proposal examination within
six months following the major field examination. A student whose initial examination
is not scheduled within 12 months, or who fails the examination twice, shall
have failed to meet the academic standards of the doctoral program.
Time to Complete Program The maximum time a student
is allowed to complete the program is 60 months, beginning with initial registration.
Not completing the program within the 60 months will likely terminate the students
enrollment in the program.
Failure of a student to meet the academic standards of the
doctoral program will result in the termination of the students enrollment
in the program. The doctoral program committee is authorized to act on behalf
of the faculty in receiving and acting on petitions for readmission. In acting
on these requests, the committee may establish such requirements and conditions
for readmission as it considers appropriate. Students may appeal decisions to
the Darden School faculty.
After the residence year has been completed, a students
tuition is calculated according to the number of semester course credits for
which the candidate is registered.


text:
A joint project between Nippon Ichi Software and HitMaker, Last Rebellion is an RPG with action elements. Players can roam around the world field and make action movements like in an action game, but once you enter battle you engage the enemy using a turn-based system. Battle System
During battle, different body parts can be targeted to disable the enemy. For instance, attacks to the legs will slow them down, while blows to the arms will weaken their attacks. By strategically striking key areas of the body, players can strip the enemy of their ability to fight.
There are 2 main characters in Last Rebellion, Nine (male) and Aisha (female). Nine is a Blade, whose specialty is physical attacks, and Aisha is a Sealer, who uses magic spells to attack & seal enemies. The player can switch back and forth between the two during the battle. Since Nine and Aisha share a single, the player must strategically choose which character to execute their attacks first. Because of this, Last Rebellion is no ordinary RPG with another mindless battle system. The player must be aware of which enemies they are fighting against, and use their experience and strategy throughout the game.
Key Features :
- Tactical battle system with interchangeable main characters
- Attractive, visual characters with lots of personality
- Gorgeous watercolor-like character art and event scenes
- A story of revenge featuring a dark anti-hero
More articles about Last Rebellion


text:
(4-Packs Special) Ardell Eye Lashes - 107 Black
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Ardell Natural Individuals Dura Eye Lashes - Flare
Get an attractive slightly flared look with a single strip of lash. They are permanently curled, weightless, waterproof and fasten comfortably to your own lashes. Each package contains 88 easy-to-apply individual lashes.
Application Direction:
Thoroughly clean your eyelashes and eyelids so they are make-up and oil free.
1 - Pour a few drops of LashTite adhesive on a piece of foil
2 - Gently lift a DuraLash from tray with tweezers
3 - Dip end into adhesive
4 - Starting at the center of the eyelid, apply lashes one at a time by placing the lash cluster on top of one of your own natural lashes with the end close to, but not touching your eyelid. Support lash gently with fingertips until adhesive sets. Work towards the outer corner. Return to center and gradually work inward until lashes blend.
Apply 10-15 lashes per eye.
DuraLashes should be replaced as your natural lashes shed. (About 4 to 5 weeks.)
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text:
This Sports Utility Vehicle is an alternative model of Creator set 5867 Super Speedster.
A classic American car from Creator set 5867 Super Speedster.
An alternate from Creator set 5867 Super Speedster, inspired by Rolls-Royce and Bentley.
Written by Joe Perez (aka MortalSwordsman)
Saturday, 09 March 2013
Written by Ronald Busscher
Saturday, 09 February 2013
© 2012 - 2016 Nathanaël Kuipers. All rights reserved. LEGO® is a trademark of The LEGO Group, which does not sponsor, own or endorse this site.


text:
Polaris is excited to have established corporate partnerships with outstanding businesses, in a variety of different industries. Together we can continue to provide exciting new products for people to enjoy.
Rapala, the market leader in the fishing tackle industry, is rapidly expanding into the ice fishing category with the formation of their new ICE FORCE brand. This new brand will be made up of Rapala, Sufix, StrikeMaster, MarCum Technologies, Otter Outdoors and Polaris to bring anglers the ultimate ice fishing experience. In addition, an Ice Force Pro Staff made up of top fishing experts will be present at all major ice fishing shows and events across the U.S. promoting this new brand.
On August 28th, Polaris announced a exciting new partnership with the Minnesota Wild, the NHL's newest expansion team from Minnesota. Wild president Tod Leiweke and Roseau native and NHL great Neal Broten were on hand to help introduce the new partnership to the Polaris employees. The day began with a presentation to the 250 employees at the Polaris headquarters and was followed by a shot at the boss session and a 40 team three-on-three street hockey tournament coined the first annual Way out Wild cup.
Mossy Oak is "America's Most Effective Concealment System." Mossy Oak camouflage patterns not only try to blend into your natural surroundings but also break your outline. Popular patterns include Forest Floor™, Break-up™, Shadow Leaf™ and Shadow Grass™. To see for yourself how effective these concealment systems are, make sure you tune into "Hunting The Country"and "Remington Country" TV programs on Sunday nights on TNN or check out Hunting The Country Magazine. Polaris features the Mossy Oak Break-up pattern on the Sportsman 500 H.O. Remington Special Edition and the Magnum 325 ATVs.


text:
There were only three channels until 1982 when Channel 4 launched and despite what people would have you believe it wasn't all wall-to-wall Fawlty Towers and Boys from the Black Stuff: there was as much rubbish then as there is now.
There was no internet or DVDs. Videos were becoming popular but television had a power that it has perhaps lost in the digital age.
Snooker was cheap to produce and offered up late night drama in the days when you could easily avoid the scores before the highlights came on.
But it was the varied cast of characters that really made snooker such a success. Like a soap opera there were heroes and villains, people you could root for and those who you wished would fall under a bus.
Snooker is still like this but the game is now a profession, largely due to the way the circuit was built in the 1980s.
Prior to this, players made their money on the exhibition circuit, where they slogged around the country trying to earn a living.
For this, they had to develop their personalities. They had to tell jokes and do trick-shots and everything they could to get asked back.
Many of them never lost that knack for entertaining off the table: Dennis Taylor and Willie Thorne for instance are both great value doing after dinner speeches and on corporate occasions.
When they started playing, there was no issue of there being "too many" tournaments. There was the World Championship and the odd event here or there, mostly for paltry prize money.
Alex Higgins earned less than £500 for winning the 1972 world title but he more than anyone had the sort of charisma that helped lead to snooker's rise and rise.
With Higgins, you not only got exciting snooker but also an atmosphere of threat, the feeling that anything could kick-off at any moment.
I heard a story that Alex did an exhibition at which a famous racehorse was brought in so they could pose for pictures, the Hurricane being a very keen follower of racing.
Except, he decided to leap on the horse's back, which startled it to the extent that it defecated all over the floor. Higgins wasn't asked back.
Exhibitions were often fraught affairs. Fred Davis turned up at one once and asked where the table was. The promoter replied: "we thought you'd bring it with you."
The laconic John Pulman had a bad experience at an exhibition which resulted in some name calling.
"Who called the organiser a c***?" someone angrily demanded.
Pulman responded: "Who called the c*** an organiser?"
Many exhibitions were held in holiday camps where there was a captive audience of holidaymakers looking to be entertained.
From this, Ted Lowe helped to found the Pontin's festival of snooker in Prestatyn, which at its height attracted all of snooker's biggest names as well as many plucky amateurs and juniors.
When Steve Davis started to become successful he ventured out on the exhibition circuit and it proved to be very lucrative for him. He's still great value now, playing up his deadpan 'interesting' image.
Today's top players don't need to do exhibitions to top up their tournament earnings but they still happen.
Jimmy White does plenty and always seems to play great in them, and last weekend Judd Trump did some in Ireland.
Jason Francis has made a success of the Snooker Legends tour, featuring some of those names who began on the exhibition road in the 1970s and are still entertaining audiences 40 years on.
Exhibitions are fun and show audiences a different side to a player's personality but they should only ever serve as an sideshow to professional snooker.
When Joe Davis retired in 1946 he still played regularly and this diminished the World Championship because everyone knew the best player in the game wasn't playing in it.
Trump and Ding Junhui have elected not to play in the new Brazilian Masters but instead take part in a televised exhibition in China.
I find it hard to believe World Snooker will sanction this because it is a very dangerous precedent at a time where the governing body is trying to build a global calendar.
Snooker is a less innocent sport since money came into it and began to influence virtually every decision.
But that's life and there's no point complaining about it. Snooker has attracted millions over the years because, as a product, it has proven itself to be popular.
It has grown to a level the guys of the 1970s, driving up another motorway to undertake an exhibition engagement, could scarcely have believed was possible.
They deserve credit and thanks for helping to make that happen.
EDIT: Since posting this yesterday, Trump's management have got in touch and asked to make the following two points:
1. The Chinese event is a promotional event to promote the game in one of the poorer underserved regions of China. Judd is keen to help promote the game's profile and was delighted to have been asked.
2. When Judd agreed to do this, we were aware of the Brazilian event but Judd was outside the top 16 and did not expect to have such a big leap so quickly. Crucially if Judd had not reached the final of the WSC he may not have received an invite to Brazil at all.
17 comments:
Off the top off your head Dave, how many players from the 70s do you recall turning down work because they were too "tired" to go on to the next engagement?
- 10:37 am
Excellent piece Dave.
It seems to me that a lot of today's players are too lazy to get out of their own way and don't know their arse from a hole in the ground.They presumably want big money tournaments but won't go out of their way to help achieve this.
These people need a big wake up call - say a couple of months scaffolding on the building sites in the winter.
What is the matter with them all? I'm very disappointed in Trump and Ding and quite a few of the other top ranking players seem to have a ME, ME, ME mentality.
There's none so blind ........ and they will never learn.
Very grateful to you at least Dave for trying your best to protect and further the interests of snooker.
- 12:08 pm
Good piece, like the John Pulman line!
- 12:18 pm
I guess China is the place for lucrative exhibitions these days. So money is competing with ranking points and silverware. Regarding the Brazilian Masters I would be apprehensive about walking around in Brazil due to the unbelievable crime statistics but I suppose it is safer than the fire pit formerly known as London.
Players only get fined if they have entered the event, right? I mean Trump and Ding can skip Brazil if they want. I just don't see why Ronnie keeps entering and then get in trouble for changing his mind. He should plan his season ahead of time and be realistic about the travelling he is willing to put in.
- 9:51 am
Off-topic 'breaking news': I read that World Snooker put a stop to tweeting during matches (see www.prosnookerblog.com).
Can you comment on this Dave? This unique fringe coverage is doing snooker a world of good so why would they decide to do this?
- 11:10 am
WS needs to stop incentivising players to miss overseas events by awarding less ranking points than UK events.
Next season's Brazil tourn is hoped to obtain ranking status. It should, along with the German and Australian Opens, award 7000 points for the winner, as is the case with the Chinese events and the world open.
Trump's excuse doesn't wash either. His management should immediately have rearranged the exhibition when he was offered the place in Brazil. He needs to play in as many tournaments as possible at his stage of his career. Perhaps his management are prioritising their percentage of Trumps earnings over an opportunity for him to get some badly needed match practise.
- 12:05 pm
If Trump has made a commitment to play another organiser's event he should honour it. It's up to World Snooker to give players enough notice of the calender so they can plan around it. Barry Hearn had plenty to say when a WSA event clashed with the Premer League one year, so he can't really criticise if players choose to honour their contractual obligations.
- 1:47 pm
- Dave H said...
They'll actually be in breach of their World Snooker contract if they play in an exhibition during a tournament
With regards to the tweeting, World Snooker need a more sensible policy rather than just banning it
- 1:49 pm
It's one thing banning players from committing to exhibitions where the date for WSA event is pre-set, but banning players from participating in exhibitions which they have committed to in good faith would open the players up to legal action from the event organisers. Since the calender is played all year round now then you're effectively banning players from doing exhibitions without WSA permission; I'm pretty sure the Monopolies Commission would come in on World Snooker if they tried to enforce those kinds of contracts. In fact didn't Hendry and Williams sue World Snooker over this type of contract a few years ago? I thought they won and exclusive contracts were outlawed?
- 2:05 pm
- TazMania said...
Didn't Barry Hearn say when he revealed the Premier League, players are only allowed to play in WS Sanctioned Televised events, if they play any non sanctioned they will be punished in some sort, so does this mean the Chinese Event is a WS Sanctioned?
- 4:48 pm
re 2.05
To be fair, Hearn has no choice but to stop Ding and Trump from doing this exhibition. Firstly, there is plenty of time after PTC 8 in Oct and before the UK in Dec to organize this exhibition.
Secondly, if Hearn allows it to go ahead it sets a dangerous precedent-who's to stop another player doing it in say, the new Indian event?
- 5:25 pm
if reaching the world final was crucial for Trump's invite, then how the hell did Mark Davis get his?
- 6:50 pm
Presumably they worked down the ranking list.
I doubt Hearn will stop the exhibition from going ahead. It would put him on collision course with the Chinese Snooker Association who organise and finance three events, and possibly four now if the World Open goes ahead. No way they will tolerate their top player being sanctioned for playing Chinese events.
- 7:19 pm
Crucially if Judd had not reached the final of the WSC he may not have received an invite to Brazil at all.
True but its also highly likely that had Judd not reached the final of the WSC he wouldnt have been Dings opponents for this invitational in China either......
- 2:51 am
It's probably more due to the fact that the Ding/Trump match received snooker's highest ever rated television audience. In China alone it drew over 50 million viewers, the only snooker match ever to do so. Ding is an obvious box office draw in his home country, but Trump's profile in China probably exceeds even Ronnie O'Sullivan now than thanks to his semi-final tie against Ding and his China Open win. Trump is probably guaranteed 20k per exhibition in China, and his exhibition earnings could easily dwarf his competition earnings, so obviously he has to prioritise his earning potential.
- 1:25 pm
If Trump didn't think he would be ranked high enough to get an invite, what was Ding's excuse? I can understand Trump's reasoning, but it looks like Ding (who is a solid top 8 player now) knew of the Brazilian Masters, presumably knew of the rules forbidding him from playing exhibitions during tournaments, and went ahead and agreed to do it anyway. The alternative is that Ding wasn't given a choice, this being China and all. As we saw with Bahrain, sometimes last minute scheduling by the WSA can cause clashes with other events and that can't be helped, and I don't think Barry would come in on a player if that were the case, but it looks like Ding has knowingly violated his WSA contract in this instance. I don't expect to see him sanctioned since if the Chinese Snooker Association back Ding there isn't much Barry can do, but what sort of precedent does that set? If you don't fine Ding, then you can't fine any other player who sets up an exhibition during an event.
- 8:15 pm
in respective of judd being in the top 16 when he accepted this invitation (which personally is a load of bull)the chances of Ding not being a top 16 player would have been minimal.
also trying to promote snooker in the poorest underserved regions of China will not bring in the punters because they are poor.
and playing TV Exhibition in china to promote snooker is a bit stupid because theres plenty of snooker in china.
go to countries that don't see much professional snooker is the way to promote snooker ie Brazil.
- 11:27 pm


text:
A Study of FV-100 Versus Valacyclovir in Patients With Herpes Zoster
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00900783
Recruitment Status : Completed
First Posted : May 13, 2009
Last Update Posted : October 12, 2015
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to compare the safety and efficacy of two doses of FV-100 to valacyclovir in patients with herpes zoster, or shingles. FV-100 has shown to be very potent in cells infected with varicella zoster virus, the virus that causes shingles. The study objectives include:
- Compare the safety of FV-100 to valacyclovir
- Compare the effect of FV-100, as compared to valacyclovir, on shingles pain
- Compare the effect of FV-100, as compared to valacyclovir, on shingles lesions
|Condition or disease
|Herpes Zoster Shingles
|Drug: valacyclovir Drug: FV-100 Drug: Valacyclovir placebo Drug: FV-100 placebo
|Phase 2
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|350 participants
|Intervention Model:
|Parallel Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Official Title:
|A Phase II, Multicenter, Randomized, Double-Blind, Parallel-Group, Comparative Study of FV-100 vs. Valacyclovir in Patients With Herpes Zoster
|Study Start Date :
|May 2009
|Actual Primary Completion Date :
|November 2010
|Actual Study Completion Date :
|December 2010
Experimental: 2
FV-100, 400 mg once daily AND valacyclovir placebo, three times a day, for seven days
Drug: FV-100
400 mg, once daily, for seven days
Drug: Valacyclovir placebo
three times a day, for seven days
Active Comparator: 3
Valacyclovir, 1 gram, three times a day AND FV-100 placebo, once daily, for seven days
Drug: valacyclovir
1 gram, three times a day for seven days
Other Name: Valtrex
Drug: FV-100 placebo
once daily, for seven days
Experimental: 1
FV-100, 200 mg once daily AND valacyclovir placebo, three times a day, for seven days
Drug: FV-100
200 mg, once daily, for seven days
Drug: Valacyclovir placebo
three times a day, for seven days
- Herpes zoster associated pain, as measured by the Zoster Brief Pain INventory (ZBPI) [ Time Frame: 30 days ]
- Herpes zoster associated pain [ Time Frame: 90 days ]
- Herpes zoster lesion healing [ Time Frame: Until healed ]
- Routine clinical labs [ Time Frame: 30 days ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|50 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Men and women ≥ 50 years of age
- Patients with a clinical diagnosis of HZ as evidenced by a unilateral dermatomal rash
- Patients with zoster-related pain (ZBPI worst pain score > 0)
- Patients able to be enrolled into the study ≤ 72 hours from appearance of rash (i.e., lesions or vesicles)
- Patients providing written informed consent
- Patients who are able to complete all study visits per protocol
- Men and premenopausal women must agree to practice a barrier method of birth control plus the use of a spermicide for one month after the last dose of study drug (oral contraceptives are not permitted)
Exclusion Criteria:
- Women who are pregnant or lactating
- Patients with multidermatomal or disseminated HZ (i.e., > 20 vesicles beyond the dermatomes adjacent to the primarily involved dermatome)
- Patients with HZ ophthalmicus, defined as cutaneous lesions in the dermatome associated with the ophthalmic division of the trigeminal nerve
- Patients with history of impaired renal function, (e.g., calculated creatinine clearance <50 mL/min/1.73 m2)
- Patients taking narcotic analgesic routinely for a chronic pain condition
- Patients taking tricyclic antidepressants
- Patients who have received systemic antivirals with activity against VZV within the past 30 days, or a topical antiviral to treat their current HZ
Patients who are immunosuppressed from:
- disease (e.g., malignancy [present or remission < 5 years], HIV)
- corticosteroid use (except intermittent or topical/inhaled beclomethasone dipropionate or equivalent < 800 mcg/day), or
- other immunosuppressive/cytotoxic therapy (cancer chemotherapy or organ transplantation)
- Patients with gastrointestinal dysfunction that could interfere with drug absorption
- Patients with any other condition (e.g., extensive psoriasis, chronic pain syndrome, cognitive impairment) that, in the opinion of the site investigator, might interfere with the evaluations required by the study
- Patients who are not ambulatory (bed-ridden or homebound); hospitalized patients may be enrolled if they are ambulatory and able to complete the study requirements
- Patients with history of allergy to valacyclovir hydrochloride
- Patients unlikely to adhere to protocol follow-up
- 14. Subjects taking strong CYP3A4-inhibiting protease inhibitors (specifically including atazanavir, indinavir, nelfinavir, saquinavir, and ritonavir), strong CYP3A4 inhibitors (specifically including clarithromycin, itraconazole, ketoconazole, nefazodone, telithromycin) and all strong CYP3A4 inducers (specifically including rifampin, efavirenz, etravirine, phenobarbital, phenytoin, and carbamazepine)
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Bristol-Myers Squibb
|ClinicalTrials.gov Identifier:
|NCT00900783 History of Changes
|Other Study ID Numbers:
|First Posted:
|May 13, 2009 Key Record Dates
|Last Update Posted:
|October 12, 2015
|Last Verified:
|September 2015
Keywords provided by Bristol-Myers Squibb:
herpes zoster
Phase II
Additional relevant MeSH terms:
Herpes Zoster
Herpesviridae Infections
DNA Virus Infections
Virus Diseases
Antiviral Agents
Anti-Infective Agents


text:
Navigating the small streams of Christian County, KY
Little River, a tributary of the Cumberland River, originates in Christian County, KY. Its floods are a recurring theme in the history of Christian County and Hopkinsville.
As I was reading old Kentucky New Era articles about Pilot Rock recently, I came across some interesting information about Little River. In the Dec. 9, 1959, issue, a columnist reprinted an old clipping that a reader had sent to him. The author and original date of publication were unknown but it was believed to be from the New Era. The topic was the navigation of Little River in pioneer days. Part of the clipping quotes a law that was passed:
An act for keeping open the navigation of Little River in Christian County, KY., approved Jan. 4, 1811.
"Whereas it is represented to the present general assembly (probably of Kentucky) that great advantage would result to the inhabitants of Christian County (organized in 1792), by prohibiting all obstructions in the navigation of Little River.
"Therefore, that from and after the passage of this act, Little River shall, as a navigable stream, remain open and unobstructed for the purpose of navigation and any person erecting or causing to be erected any fish dams, bridges or any other obstructions to passage of boats up or down said stream, shall for every offense forfeit and pay the sum of three dollars to the person aggrieved, to be recovered before a justice of the peace for every 24 hours such obstruction shall remain therein."
Source: Kentucky New Era, Dec. 9, 1959
This little item sheds some light on a question that Dennis and I had discussed a while back -- whether Little River had ever been used for shipping and transportation. We were quite sure that it had been, but it's fun to find some documentation.
The various headwaters of Little River are not very deep, but flatboats didn't need deep water. They were built at the place where the freight originated, and they were one-way vehicles. They were floated downstream, but they weren't brought back upstream.
Their [the flatboats'] cheapness and shallow draft enabled them to carry freight on most creeks worthy of the name. The produce was loaded while the creeks were more or less dry; then when a freshet occurred they were floated to the nearest river.
Source The Encyclopedia of Louisville (p. 849) by John Kleber.
After a flatboat was unloaded at the end of its trip, it was torn apart to salvage the lumber. The sale of the lumber was one more bit of income from the trip.
Dennis and I speculate that in early 19th-century Christian County, bridges across streams would have been primitive. They were probably just a tree trunk, laid across a narrow place. A fancy bridge might have been two trees, laid across the water side by side, with planks nailed across them. No wonder they were prohibited on Little River. Besides obstructing traffic, they would have snagged flood debris.
But who needed a bridge? If the river couldn't be forded, it was an opportunity for someone to make some money operating a ferry.


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Hello fellow readers,
Today, we continue my new online comic called Lila and the haunted camera! Before you read the sixth page, please do not credit, download, or share any of the comic pages that I'm going to post! Well, those are the only rules, so let's start the spooky comic!


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JOHNSON CITY (Jan. 9, 2012) – Overcoming an uninspired first half effort, the ETSU men's basketball team went to a man-to-man defense and turned up the full-court pressure in the second half, rallying for acting head coach Scott Wagers as the Buccaneers enjoyed a 73-69 win over Kennesaw State Monday evening inside the ETSU/MSHA Athletic Center.
Wagers, who was standing in so head coach Murry Bartow could attend funeral services for his father Gene in Birmingham, Ala., looked on as the Bucs won for the third straight time and improved to 8-7 overall, 3-2 in Atlantic Sun Conference play. Meanwhile, the Owls dropped to 3-14, 0-6.
"This was not a fun way to be a head coach," said Wagers, the longtime ETSU assistant. "We are all mourning the loss of Gene Bartow and all he meant to this team and to Coach Bartow. Our players knew how great a man he was, and I think we could sense the guys were a little off tonight in the first half.
"But I'm really proud of the fight they showed and the effort in the second half. Our seniors really stepped up and made big plays down the stretch, and Jarvis Jones made some big shots for us."
The Bucs, who were down by as many as 11 early in the second half, went on a 22-6 run at that point to gain a five-point edge 49-44 with 10 minutes left in the game. From there, KSU went back on top at 54-51, but again ETSU answered the run and led the rest of the way to pick up the victory.
ETSU's senior trio of Adam Sollazzo (Tampa), Tommy Hubbard (Boston) and Isiah Brown (Miami, Fla.) were key to the victory, with Hubbard posting a double-double with 15 points and 11 rebounds, Sollazzo scoring a team-high 20 points, and Brown pitching in 10 points and five boards.
Meanwhile, Jones – the junior guard from Memphis – scored 13 second-half points, and fellow junior Sheldon Cooley (Tampa) netted 12 points.
In the first half, Kennesaw State used runs of 9-0 early in the game and another 11-2 spurt in the final five minutes on the half to take a 31-23 advantage at the break. Key to the Owls' success was a 5-of-11 clip from 3-point range, led by 12 points from guard Spencer Dixon.
Overall, KSU shot 57 percent from the field in the first half and out-rebounded the Bucs 15-10. Meanwhile, ETSU's vaunted pressure defense was only able to force seven turnovers off three steals in the opening 20 minutes.
However, the second half was a different story for ETSU – thanks mainly to a switch from zone to man-to-man, as well as a re-energized full-court defensive attack. Even so, Kennesaw State still led 54-53 with just over five minutes left in the game.
From there though, the Bucs hit on 12-of-14 shots from the foul line and got timely baskets from Sollazzo, Jones, Cooley and Hubbard in the final minutes.
For Kennesaw State, Dixon led the way with a game-high 22 points, while All A-Sun performer Markeith Cummings added 17 points. In addition, Delbert Love pitched in a 12-point effort.
ETSU forced 16 turnovers on nine steals, and out-rebounded the Owls 33-25. The Bucs shot 71 percent from the foul line and 47 percent from the field, while KSU hit on 50 percent of its shots for the game and was a strong 48 percent from 3-point range.
The Bucs will be back on the road this weekend, taking on Jacksonville Saturday at 3:30 p.m., followed by a meeting with North Florida on Monday at 7 p.m. For more on ETSU men's basketball throughout the 2011-12 season, visit ETSUBucs.com and click on the men's hoops link.


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A 34-year-old Baltimore man was sentenced to 10 years in prison Monday for his role in a heroin and gun distribution ring that netted police more than a dozen weapons, $8,000 in cash and two ounces of heroin when they busted it earlier this year, according to police and the Maryland U.S. attorney's office.
Keith James, 34, of the 5000 block of Harford Road, will also have to serve three years of supervised release, after pleading guilty Monday to possession of heroin with the intent to distribute it and possession of a firearm that he was prohibited from having because of a previous conviction, prosecutors said.
The March bust, which also resulted in the arrests of Ronald Van Price, 38, of Windsor Mill, and Jessica Correa, 24, of Baltimore, was touted by police as a major victory against crime. "They got a major gun dealer off the streets," a police spokesman said at the time.
James' sentencing is the first court conclusion in the case.
In his plea agreement, James admitted to having conspired to distribute heroin, and to obtaining "bulk quantities" of the drug, diluting it with "cutting agents" and then repackaging it and selling large quantities for others to sell in single doses on the street, prosecutors said.
The agreement also acknowledges that, after being arrested and locked up on a gun charge in January, James "made several phone calls to friends and relatives seeking to have them process and sell heroin to help pay his legal and other bills, and to have others obtain and sell firearms on his behalf."
With the help of that information, police raided two apartments used by James in Baltimore in March, recovering "heroin packaging materials and paraphernalia used in the distribution of heroin," multiple kinds of ammunition, a gun cleaning kit, a gun vault and paperwork for a Park Heights Ave. storage unit, prosecutors said.
They then searched the storage unit, where they found more heroin packaging material, 12 guns — many of them loaded — two bullet-proof vests, more ammunition, two holsters and two magazines, prosecutors said.
Police at the time said homes in the 4500 block of Mary Ave., the 5000 block of Harford Road and the 2300 block of N. Rosedale St. were raided as well, as was a home in the 3300 block of Milford Mill Road in Baltimore County.
Correa, of the 2300 block of N. Rosedale St., and Price, of the 3300 block of Milford Mill Road, remain listed as codefendants in related cases at the state level, in which they are facing dozens of gun and drug trafficking charges.
Lynette James, 36, of the first block of Ojibway Road in Randallstown, is also listed as a codefendant.
Asked whether those cases would also be taken to the federal level, as James' case was, Marcy Murphy, a spokeswoman with the U.S. attorney's office, said the office does not "discuss specific charging decisions, but we work closely with the State's Attorney's Office to determine the most appropriate venue for prosecution."


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Our conference titled "Modern Scientific Facts Concerning the Emergence of Life" attracted intense participation from various departments of the university, particularly the departments of physics, biology and mathematics.
Following the conference, university students also attended an iftar dinner arranged jointly with the 'Catholic and Evangelical Student Community of Clausthal' and discussed and exchanged ideas on unity among the Divine faiths and the invalidity of Darwinism.
The Goslarsche Zeitung (23 July issue), one of the press organs covering the conference, carried a report concerning it titled "Every Art has an Artist." The piece said that a fossil exhibition was held in addition to the conference, which discussed the invalidity of the theory of evolution taking eminent scientists as its reference point, that the fossil record contains no transitional forms and that Darwinism will be history within the next 10-15 years.
Books by Harun Yahya were distributed free of charge after the conference.


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The city�s elected chief would be relegated to greeting visitors at the front door of City Hall, riding in parades and kissing babies if the city administrator measure passes.
A check of my calendar has shown there will be an election soon. This will not be a routine, boring election, for it will be one in which a president, one-third of all senators, and all 435 members of the United States House of Representatives are elected.
On the state level, the state�s electors will decide some changes to the state�s constitution; locally, Crestview residents will determine whether a new city charter will go into effect on Jan. 1, 2013.
Aside from the state issues, each voter within the state can cast his or her ballot for the presidential candidate of his or her choice: one candidate for senator, and one candidate for representative. Locally, those of us within the city of Crestview can decide the form of government that will rule the municipality, along with some other less significant but noteworthy changes.
I trust that each concerned resident has secured a draft copy of the proposed charter and has taken the time to read it and digest its contents. I have read it several times, and each time I have had different thoughts about the wording.
Let�s look at some of the major, standout provisions. In Section 4.01(a), it is stated that the mayor shall have the following powers and duties: �to be recognized as the official head of the city for all ceremonial purposes�,� and �to preside at all meetings of the city council with authority to participate in discussions, but without power to vote.�
In other words, the city�s elected chief would be relegated to greeting visitors at the front door of City Hall, riding in parades and kissing babies.
To make the incumbent feel important, the council will let the mayor rap the gavel to bring a meeting to order or adjourn it, and possibly enter into a conversation without the power to determine a considered item�s outcome. The current day responsibility to oversee public safety, like police and fire departments, would be removed. That should make the mayor feel important!
So that the city is kept in good order and with discipline, the City Council�s five elected members would select a city administrator (presumably from the outside) to run all the city�s day-to-day operations. Based on what I have read in several publications� Help Wanted columns, the going annual salary for such an individual is around $100,000 plus benefits, a city automobile and a private office, with an assistant and benefits. Added together, the cost of having such an individual employed could very easily amount to an annual outlay of $200,000, though that�s not to say Crestview�s expenditures would be the same.
Here�s how it would work: the City Council would hire the administrator, who would run the city with the council�s direction. However, the council members could do nothing unilaterally. All the council�s actions must be taken during open sessions, so a majority of council members present at a regularly scheduled meeting must first approve any direction they give. An appointed administrator has virtually no direct supervision.
To streamline City Hall�s operations, the proposed charter eliminates the elected city clerk position and provides an appointee who answers to the city administrator.
It is reasonable for one to ask �why.�
Some three years ago, it was suggested that a charter review committee analyze the existing document and recommend changes. Numerous paragraphs are no longer applicable, namely positions for a city physician and a city tax collector.
Some paragraphs are needed, namely the procedure to take if an elected official decides to resign from office. Several members in the past few years have �resigned,� but there is no �paper trail� to that effect. One can say that he or she resigns, but there is no document to prove it. Further, to whom is a letter of resignation given?
When asked why these changes to the charter were recommended, one member of the charter review committee replied, �Every town has a manager.� When the subject of an elected city clerk versus an appointed city clerk arose, it was stated that �almost all cities in Florida have one.�
Thus, the upcoming election is more that Mitt Romney versus Barack Obama, or Bill Nelson versus Bonnie Mack. It is about every citizen in Crestview and the form of government that will be in existence.
Bob Allen is a former Crestview city council member.
What's your view? Email firstname.lastname@example.com with the subject "My view." Letters must be 250 words or less and written on local issues.


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Pedroia never lost faith during tough times
BOSTON -- There was the collapse of 2011, which led to the departure of the only Major League manager Dustin Pedroia had ever played for. There was the season-long malaise of '12 -- the likes of which no Red Sox team had seen since 1965.
That was Pedroia's opportunity to lose faith in the direction of the organization that drafted him in June 2004.View Full Game Coverage
BOSTON -- There was the collapse of 2011, which led to the departure of the only Major League manager Dustin Pedroia had ever played for. There was the season-long malaise of '12 -- the likes of which no Red Sox team had seen since 1965.
That was Pedroia's opportunity to lose faith in the direction of the organization that drafted him in June 2004.View Full Game Coverage
Instead, the hard times only strengthened Pedroia's resolve and increased his desire to not just win again -- but to do so with the Boston Red Sox.
So when Pedroia runs out to the baseline on Wednesday night during introductions for Game 1 of the World Series (7:30 p.m. ET air time, 8:07 first pitch on FOX), the faith he showed in pushing for a contract extension with Boston (the one he signed three months ago) will be rewarded in the best way possible.
"It's extremely difficult to get to the World Series," said Pedroia, who is signed with Boston through 2021. "A lot of great players and great pitchers never get there. And sometimes the ball doesn't roll your way. This year, it's been fun."
Aside from his loyalty, another Pedroia trait is his strong desire to win.
That little speed bump at the end of '11 under manager Terry Francona, and the pothole that surrounded the Red Sox in all of '12 under Bobby Valentine? To Pedroia, that was just an annoyance -- and not a reason to lose his belief in the Red Sox.
"Yeah, dude, I always knew," said Pedroia. "You know that pretty much every year the Red Sox were going to compete. We had some tough times. Every organization goes through it. Ours was just one year, and a little bit at the end of the year before that. But we're headed in the right direction. Guys love coming here [to the ballpark]. It's been fun."
For all the talk about the new faces who have influenced the Red Sox, from Jonny Gomes to Shane Victorino to Mike Napoli to David Ross, Pedroia had that same mindset from the moment he arrived in Boston.
Now he has a clubhouse full of kindred spirits to go to work with.
And, in many ways, this is his team.
"If you're in the big leagues, if you're a World Series champ, if you're decorated, you're a good player," said Gomes. "I don't look at talent. You just want to see those intangibles. You want to see someone who loves the game. For someone like me who's a grinder and who has to get here early and work out and hit and study and all that stuff, you want that to be for the superstar, too. And very rarely is it. So to see the work he puts into it is awesome."
Ross had a short stint with the Red Sox in 2008, when Pedroia was in the final stages of a brilliant personal run that would land him the American League's Most Valuable Player Award. In the ensuing four years, Ross would rave to teammates and friends about the impact Pedroia made on him during that short time.
But this year, Ross has seen it up close for a full season and hasn't been disappointed.
"I would tell guys I played with on other teams since then that he was one of my favorite teammates of all time," Ross said. "Not because of how he acted -- it's more what he brings on a daily basis. He has a no-fear attitude. He makes you better. He plays hard every day. He wants to win every day. He doesn't give away one at-bat. His attitude has made a better person and player for sure."
At least so far, this hasn't been one of Pedroia's better postseasons at the plate. Through 10 games, he is hitting .256 with two doubles, no homers and six RBIs, with a .619 OPS.
If Pedroia's slump has seemingly gone under the radar, there are two reasons: He has found plenty of other ways to influence the game, and the Red Sox are winning.
Those two things seem to go hand in hand.
And it probably also makes the Cardinals wary that Pedroia is probably due to break out. But if the season ends with a parade, Pedroia won't care what he hits.
"I'm just trying to impact the game," Pedroia said. "We're trying to win, man. Nobody cares about what they do personally. It's about the team. Nobody remembers what David [Ortiz] hit in 2007 when we won the World Series. They just know we won the World Series."
And six years later, Pedroia is at last back in the World Series. He was a rookie last time around, and it didn't show. In Pedroia's first at-bat of that '07 World Series, he clocked a home run against Rockies lefty Jeff Francis to lead off the bottom of the first inning for Boston.
His second most-chronicled moment of that first Fall Classic came when he showed up to Coors Field and wanted to get into the clubhouse.
The security guard wanted his ID.
Pedroia's response was classic Pedroia. It went something like this: "Go ask Jeff Francis who I am."
Did Pedroia ever think it would take six years to get back?
"I never really thought about it," Pedroia said. "You just keep playing until they tell you to stop. You don't want to lose. You just keep showing up and trying to win that day. That's our mindset -- even this year. It's been that in previous years but we didn't win."
This year, it has all come together again, and Pedroia will try to enjoy his second trip to the World Series in ways he just couldn't the first time.
"Yeah, 2007, it happened so fast," Pedroia said. "I didn't even know what was going on. Now, I'm trying to enjoy every step and just take it all in."
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne.


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William Shakespeare
William Shakespeare (26 April 1564 - 23 April 1616 / Warwickshire)
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Sonnet 47: Betwixt Mine Eye And Heart A League Is Took
Betwixt mine eye and heart a league is took,
And each doth good turns now unto the other,
When that mine eye is famished for a look,
Or heart in love with sighs himself doth smother,
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