text:
Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01522976
Recruitment Status : Active, not recruiting
First Posted : February 1, 2012
Results First Posted : March 22, 2016
Last Update Posted : December 17, 2018
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|Condition or disease
|Chronic Myelomonocytic Leukemia Chronic Myelomonocytic Leukemia-1 Chronic Myelomonocytic Leukemia-2 Myelodysplastic Syndrome Myelodysplastic Syndrome With Excess Blasts Myelodysplastic Syndrome With Excess Blasts-1 Myelodysplastic Syndrome With Excess Blasts-2 Previously Treated Myelodysplastic Syndrome
|Drug: Azacitidine Other: Laboratory Biomarker Analysis Drug: Lenalidomide Drug: Vorinostat
|Phase 2
Show Detailed Description
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|282 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Randomized Phase II/III Study of Azacitidine in Combination With Lenalidomide (NSC-703813) vs. Azacitidine Alone vs. Azacitidine in Combination With Vorinostat (NSC-701852) for Higher-Risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML)
|Actual Study Start Date :
|March 1, 2012
|Actual Primary Completion Date :
|June 1, 2015
Experimental: Arm I (azacitidine and lenalidomide)
Patients receive azacitidine SC or IV on days 1-7 or days 1-5 and 8-9, and lenalidomide PO QD on days 1-21. Courses repeat every 28 days for up to 5 years in the absence of disease progression or unacceptable toxicity.
Drug: Azacitidine
Given SC or IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Lenalidomide
Given PO
Other Names:
Experimental: Arm II (azacitidine)
Patients receive azacitidine as in Arm I. Courses repeat every 28 days for up to 5 years in the absence of disease progression or unacceptable toxicity.
Drug: Azacitidine
Given SC or IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Experimental: Arm III (azacitidine and vorinostat)
Patients receive azacitidine as in Arm I and vorinostat PO BID on days 3-9. Courses repeat every 28 days for up to 5 years in the absence of disease progression or unacceptable toxicity.
Drug: Azacitidine
Given SC or IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Vorinostat
Given PO
Other Names:
- Response Rate (Phase II) [ Time Frame: Up to 5 years ]A response is any of complete hematological remission, partial remission, or hematologic improvement.
- Overall Survival (Phase III) [ Time Frame: Up to 5 years ]OS is calculated for all patients from the date of initial registration to date of death due to any cause. The follow-up for patients last known to be alive is censored at the date of last contact. Stratified Cox regression models will be used to compare OS of the combination arm selected in the Phase II portion of the trial to OS of the single-agent azacitidine arm.
- Relapse-free Survival [ Time Frame: Up to 5 years ]RFS is calculated for patients who have achieved a response. RFS will be measured from the date of response to the date of first documentation of relapse from response (as defined in the primary objective), or death due to any cause. The follow-up for patients last known to be alive and without report of relapse is censored at the date of last contact. RFS will be estimated for each of the three arms using the Kaplan-Meier method.
- Overall Survival [ Time Frame: Up to 5 years ]OS is calculated for all patients from the date of initial registration to date of death due to any cause. The follow- up for patients last known to be alive is censored at the date of last contact. OS will be estimated for each of the three arms using the Kaplan-Meier method.
- Pre-study Cytogenetic Abnormalities [ Time Frame: Up to 5 years ]Cytogenetic risk group is used to identify cytogenetic abnormalities.
- Toxicity Rate [ Time Frame: Up to 5 years ]Adverse events that are possibly, probably or definitely related to study drug are reported.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Patients must have morphologically confirmed diagnosis of myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) based on one of the following:
French-American-British (FAB) classifications:
- Refractory anemia with excess blasts (RAEB - defined as having 5-20% myeloblasts in the bone marrow)
- Chronic myelomonocytic leukemia (CMML) with 10-19% myeloblasts in the bone marrow and/or 5-19% blasts in the blood
World Health Organization (WHO) classifications:
- Refractory anemia with excess blasts-1 (RAEB-1 - defined as having 5-9% myeloblasts in the bone marrow)
- Refractory anemia with excess blasts-2 (RAEB-2 - defined as having 10-19% myeloblasts in the bone marrow and/or 5-19% blasts in the blood)
- Chronic myelomonocytic leukemia-1 (CMML-1 - defined as having < 10% myeloblasts in the bone marrow and/or < 5% blasts in the blood)
- Chronic myelomonocytic leukemia-2 (CMML-2 - defined as having 10-19% myeloblasts in the bone marrow and/or 5-19% blasts in the blood) OR
- International prognostic score (IPSS) of intermediate 2 (1.5-2.0 points) or high (>= 2.5 points); a score of intermediate 1 (0.5-1.0 points) is only allowable in the setting of >= 5% myeloblasts
- NOTE: Patients with acute myeloid leukemia (AML) are not eligible
- Procedures to obtain specimens for establishing baseline disease must be done within 30 days prior to registration
- Patients must not have received lenalidomide, azacitidine, vorinostat, or decitabine as treatment previously; any hematopoietic growth factors must be stopped for at least 14 days prior to registration; patients may have received low-dose cytarabine for MDS treatment previously, but they must have discontinued its use for at least 28 days prior to registration; patients may have received prior hydroxyurea per CMML treatment previously, but they must have discontinued its use for at least 7 days prior to registration; these patients will not be eligible if white blood cell (WBC) > 30,000/mm^3
- Patients must not have received radiation therapy, chemotherapy, or cytotoxic therapy to treat conditions other than MDS within 12 months prior to registration
- Patients must not have undergone prior allogeneic stem cell or bone marrow transplantation at any time; patients that have undergone an autologous stem cell transplant are eligible
- Patients must not have used or be using histone deacetylase (HDAC) inhibitor agents for anticancer treatment
- Patients may not have received agents such as valproic acid for epilepsy within 30 days prior to registration
- Patients must have Zubrod performance status of 0-2
- Patients must not have any pre-existing neurotoxicity/neuropathy of >= grade 2 according to the National Cancer Institute (NCI) Common Toxicity Criteria version 4.0, or prior >= grade 3 allergic reaction/hypersensitivity or rash to thalidomide, that has not resolved to < grade 2
- Patients must not have any serious medical condition, laboratory abnormality, or psychiatric illness that, in the view of the treating physician, would place the participant at an unacceptable risk if he or she were to participate in the study or would prevent that person from giving informed consent
- Patients must not have history of thromboembolic event or other condition requiring current use of anticoagulation with Coumadin (warfarin) or low molecular-weight heparin
- Patients must not have known or suspected hypersensitivity to mannitol
- Patients must receive a 12-lead electrocardiogram (EKG), chest x-ray or computed tomography (CT) scan, serum creatinine, complete metabolic panel including serum glutamic oxaloacetic transaminase (SGOT) or serum glutamate pyruvate transaminase (SGPT), electrolytes, and bilirubin testing within 28 days prior to registration in order to establish baseline measurements; questions regarding patient safety in regards to results of these tests should be directed to the study chair
Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10 - 14 days prior to registration; FCBP must agree to have a second pregnancy test within 24 hours prior to starting cycle 1 if randomized to receive lenalidomide
- Further, patients commit to the following if they are randomized to receive lenalidomide: FCBP must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy; a FCBP is a sexually mature woman who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); all patients must be counseled by a trained counselor every 28 days about pregnancy precautions and risks of fetal exposure
- NOTE: Patients not randomized to receive lenalidomide will not be required to undergo serial pregnancy testing or lenalidomide counseling after registration
- No prior malignancy is allowed except for adequately treated basal cell (or squamous cell) skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for three years
Cytogenetics requirements:
- Southwestern Oncology Group (SWOG) (and other sites not affiliated with Alliance or Eastern Cooperative Oncology Group [ECOG]-American College of Radiology Imaging Network [ACRIN]): Pretreatment cytogenetics must be performed on all patients; collection of pretreatment specimens must be completed within 30 days prior to registration to S1117; specimens must be submitted to the site's preferred Clinical Laboratory Improvement Amendments (CLIA)-approved cytogenetics laboratory; reports of the results must be submitted as described; note that cytogenetics are required at other timepoints; NOTE: National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) sites may submit specimens to College of American Pathologists (CAP) or Ontario Laboratory Accreditation (OLA)-approved laboratories providing the lab is licensed to perform fluorescent in situ hybridization (FISH) analysis
- Alliance: Alliance patients must enroll on Cancer and Leukemia Group B (CALGB) 8461, the cytogenetics protocol; CALGB 8461 provides sample procurement and submission instructions to Alliance-approved institutional cytogeneticists; note that cytogenetics are required at other timepoints
- ECOG-ACRIN: Pretreatment cytogenetics must be performed on all patients; collection of pretreatment specimens must be completed within 30 days prior to registration to S1117; specimens must be submitted to the site's preferred CLIA-approved cytogenetics laboratory; karyotypes and reports must be submitted for review to the Mayo Clinic Cytogenetics Laboratory in Rochester; note that cytogenetics testing is required at other timepoints
Banking requirements:
- SWOG, Alliance and ECOG-ACRIN (and other sites not affiliated with NCIC CTG): Patients must be offered participation in specimen banking; with patient consent, specimens must be submitted as outlined
- Alliance: (Temporarily Closed 2/28/14): As of February 28, 2014, CALGB 9665 has been temporarily closed, so Alliance patients under consideration for S1117 are NOT to be registered to CALGB 9665 and no specimens for patients enrolled after February 28, 2014 are to be submitted via this ancillary study; these patients should submit specimens per SWOG instructions; patients already enrolled on CALGB 9665 should continue to submit specimens per instructions in CALGB 9665
- NCIC CTG: NCIC CTG patients must be offered participation in specimen submission and banking; with patient consent, specimens must be submitted as outlined
- All patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
- As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01522976
Hide Study Locations
|United States, Alabama
|University of Alabama at Birmingham Cancer Center
|Birmingham, Alabama, United States, 35233
|University of South Alabama Mitchell Cancer Institute
|Mobile, Alabama, United States, 36688
|United States, Arizona
|Mayo Clinic in Arizona
|Scottsdale, Arizona, United States, 85259
|University of Arizona Cancer Center-North Campus
|Tucson, Arizona, United States, 85719
|The University of Arizona Medical Center-University Campus
|Tucson, Arizona, United States, 85724
|United States, Arkansas
|Veteran's Administration Medical Center
|Little Rock, Arkansas, United States, 72205
|United States, California
|Kaiser Permanente-Deer Valley Medical Center
|Antioch, California, United States, 94531
|City of Hope Comprehensive Cancer Center
|Duarte, California, United States, 91010
|USC / Norris Comprehensive Cancer Center
|Los Angeles, California, United States, 90033
|Kaiser Permanente-Oakland
|Oakland, California, United States, 94611
|Stanford Cancer Institute Palo Alto
|Palo Alto, California, United States, 94304
|Kaiser Permanente-Richmond
|Richmond, California, United States, 94801
|Kaiser Permanente-South Sacramento
|Sacramento, California, United States, 95823
|Kaiser Permanente - Sacramento
|Sacramento, California, United States, 95825
|Kaiser Permanente-San Francisco
|San Francisco, California, United States, 94115
|Kaiser Permanente-Santa Teresa-San Jose
|San Jose, California, United States, 95119
|Kaiser Permanente-San Rafael
|San Rafael, California, United States, 94903
|Kaiser Permanente Medical Center - Santa Clara
|Santa Clara, California, United States, 95051
|Kaiser Permanente-Santa Rosa
|Santa Rosa, California, United States, 95403
|Sutter Pacific Medical Foundation
|Santa Rosa, California, United States, 95403
|Kaiser Permanente-South San Francisco
|South San Francisco, California, United States, 94080
|Kaiser Permanente-Vallejo
|Vallejo, California, United States, 94589
|Kaiser Permanente-Walnut Creek
|Walnut Creek, California, United States, 94596
|United States, Colorado
|The Medical Center of Aurora
|Aurora, Colorado, United States, 80012
|University of Colorado Hospital
|Aurora, Colorado, United States, 80045
|Boulder Community Hospital
|Boulder, Colorado, United States, 80301
|Penrose-Saint Francis Healthcare
|Colorado Springs, Colorado, United States, 80907
|Porter Adventist Hospital
|Denver, Colorado, United States, 80210
|Colorado Blood Cancer Institute
|Denver, Colorado, United States, 80218
|Presbyterian - Saint Lukes Medical Center - Health One
|Denver, Colorado, United States, 80218
|Rocky Mountain Cancer Centers-Midtown
|Denver, Colorado, United States, 80218
|SCL Health Saint Joseph Hospital
|Denver, Colorado, United States, 80218
|Rocky Mountain Cancer Centers-Rose
|Denver, Colorado, United States, 80220
|Rose Medical Center
|Denver, Colorado, United States, 80220
|Colorado Cancer Research Program NCORP
|Denver, Colorado, United States, 80222
|Mercy Medical Center
|Durango, Colorado, United States, 81301
|Comprehensive Cancer Care and Research Institute of Colorado LLC
|Englewood, Colorado, United States, 80113
|Swedish Medical Center
|Englewood, Colorado, United States, 80113
|Poudre Valley Hospital
|Fort Collins, Colorado, United States, 80524
|Mountain Blue Cancer Care Center
|Golden, Colorado, United States, 80401
|North Colorado Medical Center
|Greeley, Colorado, United States, 80631
|Rocky Mountain Cancer Centers-Greenwood Village
|Greenwood Village, Colorado, United States, 80111
|Rocky Mountain Cancer Centers-Lakewood
|Lakewood, Colorado, United States, 80228
|Saint Anthony Hospital
|Lakewood, Colorado, United States, 80228
|Littleton Adventist Hospital
|Littleton, Colorado, United States, 80122
|Rocky Mountain Cancer Centers-Sky Ridge
|Lone Tree, Colorado, United States, 80124
|Sky Ridge Medical Center
|Lone Tree, Colorado, United States, 80124
|Longmont United Hospital
|Longmont, Colorado, United States, 80501
|McKee Medical Center
|Loveland, Colorado, United States, 80539
|Parker Adventist Hospital
|Parker, Colorado, United States, 80138
|Rocky Mountain Cancer Centers-Parker
|Parker, Colorado, United States, 80138
|Saint Mary Corwin Medical Center
|Pueblo, Colorado, United States, 81004
|SCL Health Lutheran Medical Center
|Wheat Ridge, Colorado, United States, 80033
|United States, Connecticut
|University of Connecticut
|Farmington, Connecticut, United States, 06030
|Smilow Cancer Hospital Care Center at Saint Francis
|Hartford, Connecticut, United States, 06105
|The Hospital of Central Connecticut
|New Britain, Connecticut, United States, 06050
|United States, Delaware
|Beebe Medical Center
|Lewes, Delaware, United States, 19958
|Christiana Care Health System-Christiana Hospital
|Newark, Delaware, United States, 19718
|United States, District of Columbia
|Sibley Memorial Hospital
|Washington, District of Columbia, United States, 20016
|Veterans Affairs Medical Center -Washington DC
|Washington, District of Columbia, United States, 20422
|United States, Florida
|University of Florida Health Science Center - Gainesville
|Gainesville, Florida, United States, 32610
|Jupiter Medical Center
|Jupiter, Florida, United States, 33458
|Mount Sinai Medical Center
|Miami Beach, Florida, United States, 33140
|Florida Hospital Orlando
|Orlando, Florida, United States, 32803
|United States, Georgia
|Augusta University Medical Center
|Augusta, Georgia, United States, 30912
|United States, Hawaii
|Hawaii Cancer Care Inc-POB II
|Honolulu, Hawaii, United States, 96813
|Straub Clinic and Hospital
|Honolulu, Hawaii, United States, 96813
|University of Hawaii Cancer Center
|Honolulu, Hawaii, United States, 96813
|Hawaii Oncology Inc-Kuakini
|Honolulu, Hawaii, United States, 96817
|Kaiser Permanente Moanalua Medical Center
|Honolulu, Hawaii, United States, 96819
|United States, Idaho
|Saint Alphonsus Cancer Care Center-Boise
|Boise, Idaho, United States, 83706
|Kootenai Cancer Center
|Post Falls, Idaho, United States, 83854
|United States, Illinois
|Illinois CancerCare-Bloomington
|Bloomington, Illinois, United States, 61704
|Illinois CancerCare-Canton
|Canton, Illinois, United States, 61520
|Illinois CancerCare-Carthage
|Carthage, Illinois, United States, 62321
|Hematology and Oncology Associates
|Chicago, Illinois, United States, 60611
|Northwestern University
|Chicago, Illinois, United States, 60611
|University of Illinois
|Chicago, Illinois, United States, 60612
|University of Chicago Comprehensive Cancer Center
|Chicago, Illinois, United States, 60637
|Decatur Memorial Hospital
|Decatur, Illinois, United States, 62526
|Heartland Cancer Research NCORP
|Decatur, Illinois, United States, 62526
|Illinois CancerCare-Eureka
|Eureka, Illinois, United States, 61530
|NorthShore University HealthSystem-Evanston Hospital
|Evanston, Illinois, United States, 60201
|Illinois CancerCare-Galesburg
|Galesburg, Illinois, United States, 61401
|Illinois CancerCare-Havana
|Havana, Illinois, United States, 62644
|Illinois CancerCare-Kewanee Clinic
|Kewanee, Illinois, United States, 61443
|Illinois CancerCare-Macomb
|Macomb, Illinois, United States, 61455
|Loyola University Medical Center
|Maywood, Illinois, United States, 60153
|Trinity Medical Center
|Moline, Illinois, United States, 61265
|Illinois CancerCare-Monmouth
|Monmouth, Illinois, United States, 61462
|Illinois CancerCare-Community Cancer Center
|Normal, Illinois, United States, 61761
|Illinois CancerCare-Ottawa Clinic
|Ottawa, Illinois, United States, 61350
|Illinois CancerCare-Pekin
|Pekin, Illinois, United States, 61554
|Illinois CancerCare-Peoria
|Peoria, Illinois, United States, 61615
|Illinois CancerCare-Peru
|Peru, Illinois, United States, 61354
|Illinois CancerCare-Princeton
|Princeton, Illinois, United States, 61356
|Swedish American Hospital
|Rockford, Illinois, United States, 61104
|SwedishAmerican Regional Cancer Center/ACT
|Rockford, Illinois, United States, 61114
|Memorial Medical Center
|Springfield, Illinois, United States, 62781
|Carle Cancer Center
|Urbana, Illinois, United States, 61801
|United States, Indiana
|Premier Oncology Hematology Associates
|Merrillville, Indiana, United States, 46410
|United States, Iowa
|McFarland Clinic PC - Ames
|Ames, Iowa, United States, 50010
|University of Iowa/Holden Comprehensive Cancer Center
|Iowa City, Iowa, United States, 52242
|Siouxland Regional Cancer Center
|Sioux City, Iowa, United States, 51101
|Covenant Medical Center
|Waterloo, Iowa, United States, 50702
|United States, Kansas
|University of Kansas Cancer Center
|Kansas City, Kansas, United States, 66160
|Kansas City NCI Community Oncology Research Program
|Prairie Village, Kansas, United States, 66208
|Cotton O'Neil Cancer Center / Stormont Vail Health
|Topeka, Kansas, United States, 66606
|United States, Kentucky
|University of Kentucky/Markey Cancer Center
|Lexington, Kentucky, United States, 40536
|United States, Louisiana
|Ochsner Health Center-Summa
|Baton Rouge, Louisiana, United States, 70809
|Ochsner Medical Center Jefferson
|New Orleans, Louisiana, United States, 70121
|Louisiana State University Health Sciences Center Shreveport
|Shreveport, Louisiana, United States, 71103
|United States, Maine
|Eastern Maine Medical Center
|Bangor, Maine, United States, 04401
|United States, Maryland
|Johns Hopkins University/Sidney Kimmel Cancer Center
|Baltimore, Maryland, United States, 21287
|Union Hospital of Cecil County
|Elkton, Maryland, United States, 21921
|United States, Massachusetts
|Massachusetts General Hospital Cancer Center
|Boston, Massachusetts, United States, 02114
|Dana-Farber Cancer Institute
|Boston, Massachusetts, United States, 02215
|Steward Saint Elizabeth's Medical Center
|Brighton, Massachusetts, United States, 02135
|Baystate Medical Center
|Springfield, Massachusetts, United States, 01199
|University of Massachusetts Medical School
|Worcester, Massachusetts, United States, 01655
|United States, Michigan
|Michigan Cancer Research Consortium NCORP
|Ann Arbor, Michigan, United States, 48106
|Saint Joseph Mercy Hospital
|Ann Arbor, Michigan, United States, 48106
|Bronson Battle Creek
|Battle Creek, Michigan, United States, 49017
|Wayne State University/Karmanos Cancer Institute
|Detroit, Michigan, United States, 48201
|Ascension Saint John Hospital
|Detroit, Michigan, United States, 48236
|Green Bay Oncology - Escanaba
|Escanaba, Michigan, United States, 49829
|Cancer Research Consortium of West Michigan NCORP
|Grand Rapids, Michigan, United States, 49503
|Mercy Health Saint Mary's
|Grand Rapids, Michigan, United States, 49503
|Spectrum Health at Butterworth Campus
|Grand Rapids, Michigan, United States, 49503
|Green Bay Oncology - Iron Mountain
|Iron Mountain, Michigan, United States, 49801
|West Michigan Cancer Center
|Kalamazoo, Michigan, United States, 49007
|Mercy Health Mercy Campus
|Muskegon, Michigan, United States, 49444
|Lake Huron Medical Center
|Port Huron, Michigan, United States, 48060
|Spectrum Health Reed City Hospital
|Reed City, Michigan, United States, 49677
|Munson Medical Center
|Traverse City, Michigan, United States, 49684
|Saint John Macomb-Oakland Hospital
|Warren, Michigan, United States, 48093
|United States, Minnesota
|Sanford Joe Lueken Cancer Center
|Bemidji, Minnesota, United States, 56601
|Fairview Ridges Hospital
|Burnsville, Minnesota, United States, 55337
|Mercy Hospital
|Coon Rapids, Minnesota, United States, 55433
|Essentia Health Cancer Center
|Duluth, Minnesota, United States, 55805
|Fairview-Southdale Hospital
|Edina, Minnesota, United States, 55435
|Unity Hospital
|Fridley, Minnesota, United States, 55432
|Hutchinson Area Health Care
|Hutchinson, Minnesota, United States, 55350
|Minnesota Oncology Hematology PA-Maplewood
|Maplewood, Minnesota, United States, 55109
|Saint John's Hospital - Healtheast
|Maplewood, Minnesota, United States, 55109
|Abbott-Northwestern Hospital
|Minneapolis, Minnesota, United States, 55407
|Hennepin County Medical Center
|Minneapolis, Minnesota, United States, 55415
|Minneapolis Veterans Medical Center
|Minneapolis, Minnesota, United States, 55417
|North Memorial Medical Health Center
|Robbinsdale, Minnesota, United States, 55422
|Mayo Clinic
|Rochester, Minnesota, United States, 55905
|Coborn Cancer Center at Saint Cloud Hospital
|Saint Cloud, Minnesota, United States, 56303
|Metro Minnesota Community Oncology Research Consortium
|Saint Louis Park, Minnesota, United States, 55416
|Park Nicollet Clinic - Saint Louis Park
|Saint Louis Park, Minnesota, United States, 55416
|Regions Hospital
|Saint Paul, Minnesota, United States, 55101
|United Hospital
|Saint Paul, Minnesota, United States, 55102
|Saint Francis Regional Medical Center
|Shakopee, Minnesota, United States, 55379
|Lakeview Hospital
|Stillwater, Minnesota, United States, 55082
|Ridgeview Medical Center
|Waconia, Minnesota, United States, 55387
|Rice Memorial Hospital
|Willmar, Minnesota, United States, 56201
|Minnesota Oncology Hematology PA-Woodbury
|Woodbury, Minnesota, United States, 55125
|United States, Mississippi
|University of Mississippi Medical Center
|Jackson, Mississippi, United States, 39216
|United States, Missouri
|Saint Francis Medical Center
|Cape Girardeau, Missouri, United States, 63703
|Veterans Administration
|Columbia, Missouri, United States, 65201
|University of Missouri - Ellis Fischel
|Columbia, Missouri, United States, 65212
|Saint Luke's Hospital of Kansas City
|Kansas City, Missouri, United States, 64111
|Mercy Hospital Saint Louis
|Saint Louis, Missouri, United States, 63141
|Saint Louis-Cape Girardeau CCOP
|Saint Louis, Missouri, United States, 63141
|United States, Montana
|Billings Clinic Cancer Center
|Billings, Montana, United States, 59101
|Bozeman Deaconess Hospital
|Bozeman, Montana, United States, 59715
|United States, New Jersey
|Cooper Hospital University Medical Center
|Camden, New Jersey, United States, 08103
|United States, New Mexico
|University of New Mexico Cancer Center
|Albuquerque, New Mexico, United States, 87102
|Presbyterian Kaseman Hospital
|Albuquerque, New Mexico, United States, 87110
|United States, New York
|Montefiore Medical Center-Weiler Hospital
|Bronx, New York, United States, 10461
|Montefiore Medical Center - Moses Campus
|Bronx, New York, United States, 10467
|Roswell Park Cancer Institute
|Buffalo, New York, United States, 14263
|Northwell Health/Center for Advanced Medicine
|Lake Success, New York, United States, 11042
|North Shore University Hospital
|Manhasset, New York, United States, 11030
|NYU Winthrop Hospital
|Mineola, New York, United States, 11501
|Weill Medical College of Cornell University
|New York, New York, United States, 10065
|University of Rochester
|Rochester, New York, United States, 14642
|United States, North Carolina
|Randolph Hospital
|Asheboro, North Carolina, United States, 27203
|Wayne Memorial Hospital
|Goldsboro, North Carolina, United States, 27534
|Cone Health Cancer Center
|Greensboro, North Carolina, United States, 27403
|Margaret R Pardee Memorial Hospital
|Hendersonville, North Carolina, United States, 28791
|Vidant Oncology-Kinston
|Kinston, North Carolina, United States, 28501
|FirstHealth of the Carolinas-Moore Regional Hospital
|Pinehurst, North Carolina, United States, 28374
|Annie Penn Memorial Hospital
|Reidsville, North Carolina, United States, 27320
|Iredell Memorial Hospital
|Statesville, North Carolina, United States, 28677
|Southeast Clinical Oncology Research (SCOR) Consortium NCORP
|Winston-Salem, North Carolina, United States, 27104
|United States, North Dakota
|Mid Dakota Clinic
|Bismarck, North Dakota, United States, 58501
|Sanford Bismarck Medical Center
|Bismarck, North Dakota, United States, 58501
|Roger Maris Cancer Center
|Fargo, North Dakota, United States, 58122
|Sanford Broadway Medical Center
|Fargo, North Dakota, United States, 58122
|Sanford Clinic North-Fargo
|Fargo, North Dakota, United States, 58122
|United States, Ohio
|Cleveland Clinic Cancer Center Beachwood
|Beachwood, Ohio, United States, 44122
|University of Cincinnati/Barrett Cancer Center
|Cincinnati, Ohio, United States, 45219
|Case Western Reserve University
|Cleveland, Ohio, United States, 44106
|Cleveland Clinic Cancer Center/Fairview Hospital
|Cleveland, Ohio, United States, 44111
|Cleveland Clinic Foundation
|Cleveland, Ohio, United States, 44195
|Riverside Methodist Hospital
|Columbus, Ohio, United States, 43214
|Columbus NCI Community Oncology Research Program
|Columbus, Ohio, United States, 43215
|The Mark H Zangmeister Center
|Columbus, Ohio, United States, 43219
|Mount Carmel Health Center West
|Columbus, Ohio, United States, 43222
|Miami Valley Hospital
|Dayton, Ohio, United States, 45409
|Cleveland Clinic Cancer Center Independence
|Independence, Ohio, United States, 44131
|Marietta Memorial Hospital
|Marietta, Ohio, United States, 45750
|Hillcrest Hospital Cancer Center
|Mayfield Heights, Ohio, United States, 44124
|Licking Memorial Hospital
|Newark, Ohio, United States, 43055
|University Hospitals Parma Medical Center
|Parma, Ohio, United States, 44129
|North Coast Cancer Care
|Sandusky, Ohio, United States, 44870
|Springfield Regional Medical Center
|Springfield, Ohio, United States, 45505
|Cleveland Clinic Cancer Center Strongsville
|Strongsville, Ohio, United States, 44136
|ProMedica Flower Hospital
|Sylvania, Ohio, United States, 43560
|University of Toledo
|Toledo, Ohio, United States, 43614
|Saint Ann's Hospital
|Westerville, Ohio, United States, 43081
|Cleveland Clinic Wooster Family Health and Surgery Center
|Wooster, Ohio, United States, 44691
|United States, Oklahoma
|Cancer Care Associates-Norman
|Norman, Oklahoma, United States, 73071
|University of Oklahoma Health Sciences Center
|Oklahoma City, Oklahoma, United States, 73104
|Mercy Hospital Oklahoma City
|Oklahoma City, Oklahoma, United States, 73120
|United States, Oregon
|Legacy Mount Hood Medical Center
|Gresham, Oregon, United States, 97030
|Providence Milwaukie Hospital
|Milwaukie, Oregon, United States, 97222
|Providence Newberg Medical Center
|Newberg, Oregon, United States, 97132
|Providence Willamette Falls Medical Center
|Oregon City, Oregon, United States, 97045
|Legacy Good Samaritan Hospital and Medical Center
|Portland, Oregon, United States, 97210
|Providence Portland Medical Center
|Portland, Oregon, United States, 97213
|Providence Saint Vincent Medical Center
|Portland, Oregon, United States, 97225
|United States, Pennsylvania
|Lehigh Valley Hospital-Cedar Crest
|Allentown, Pennsylvania, United States, 18103
|Carlisle Regional Cancer Center
|Carlisle, Pennsylvania, United States, 17015
|Geisinger Medical Center
|Danville, Pennsylvania, United States, 17822
|Doylestown Hospital
|Doylestown, Pennsylvania, United States, 18901
|Geisinger Medical Center-Cancer Center Hazleton
|Hazleton, Pennsylvania, United States, 18201
|Penn State Milton S Hershey Medical Center
|Hershey, Pennsylvania, United States, 17033-0850
|University of Pittsburgh Cancer Institute (UPCI)
|Pittsburgh, Pennsylvania, United States, 15232
|Guthrie Medical Group PC-Robert Packer Hospital
|Sayre, Pennsylvania, United States, 18840
|Reading Hospital
|West Reading, Pennsylvania, United States, 19611
|Geisinger Wyoming Valley/Henry Cancer Center
|Wilkes-Barre, Pennsylvania, United States, 18711
|United States, South Carolina
|Roper Hospital
|Charleston, South Carolina, United States, 29401
|Saint Francis Hospital
|Greenville, South Carolina, United States, 29601
|Greenville Health System Cancer Institute-Butternut
|Greenville, South Carolina, United States, 29605
|Greenville Health System Cancer Institute-Faris
|Greenville, South Carolina, United States, 29605
|Greenville Memorial Hospital
|Greenville, South Carolina, United States, 29605
|Greenville Health System Cancer Institute-Eastside
|Greenville, South Carolina, United States, 29615
|Greenville Health System Cancer Institute-Seneca
|Seneca, South Carolina, United States, 29672
|Spartanburg Medical Center
|Spartanburg, South Carolina, United States, 29303
|Greenville Health System Cancer Institute-Spartanburg
|Spartanburg, South Carolina, United States, 29307
|United States, South Dakota
|Rapid City Regional Hospital
|Rapid City, South Dakota, United States, 57701
|Sanford Cancer Center Oncology Clinic
|Sioux Falls, South Dakota, United States, 57104
|Sanford USD Medical Center - Sioux Falls
|Sioux Falls, South Dakota, United States, 57117-5134
|United States, Tennessee
|Thompson Cancer Survival Center
|Knoxville, Tennessee, United States, 37916
|Vanderbilt University/Ingram Cancer Center
|Nashville, Tennessee, United States, 37232
|United States, Texas
|The Don and Sybil Harrington Cancer Center
|Amarillo, Texas, United States, 79106
|UT Southwestern/Simmons Cancer Center-Dallas
|Dallas, Texas, United States, 75390
|United States, Utah
|Huntsman Cancer Institute/University of Utah
|Salt Lake City, Utah, United States, 84112
|United States, Virginia
|Sovah Health Martinsville
|Martinsville, Virginia, United States, 24115
|United States, Washington
|PeaceHealth Southwest Medical Center
|Vancouver, Washington, United States, 98664
|United States, West Virginia
|West Virginia University Healthcare
|Morgantown, West Virginia, United States, 26506
|United States, Wisconsin
|Marshfield Clinic-Chippewa Center
|Chippewa Falls, Wisconsin, United States, 54729
|HSHS Sacred Heart Hospital
|Eau Claire, Wisconsin, United States, 54701
|Marshfield Clinic Cancer Center at Sacred Heart
|Eau Claire, Wisconsin, United States, 54701
|Green Bay Oncology at Saint Vincent Hospital
|Green Bay, Wisconsin, United States, 54301-3526
|Saint Vincent Hospital Cancer Center Green Bay
|Green Bay, Wisconsin, United States, 54301
|Green Bay Oncology Limited at Saint Mary's Hospital
|Green Bay, Wisconsin, United States, 54303
|Saint Vincent Hospital Cancer Center at Saint Mary's
|Green Bay, Wisconsin, United States, 54303
|Aurora BayCare Medical Center
|Green Bay, Wisconsin, United States, 54311
|Mercy Health System
|Janesville, Wisconsin, United States, 53547
|Gundersen Lutheran Medical Center
|La Crosse, Wisconsin, United States, 54601
|Dean Hematology and Oncology Clinic
|Madison, Wisconsin, United States, 53717
|Aurora Bay Area Medical Group-Marinette
|Marinette, Wisconsin, United States, 54143
|Bay Area Medical Center
|Marinette, Wisconsin, United States, 54143
|Marshfield Clinic
|Marshfield, Wisconsin, United States, 54449
|Marshfield Medical Center
|Marshfield, Wisconsin, United States, 54449
|Froedtert and the Medical College of Wisconsin
|Milwaukee, Wisconsin, United States, 53226
|Marshfield Clinic-Minocqua Center
|Minocqua, Wisconsin, United States, 54548
|ProHealth Oconomowoc Memorial Hospital
|Oconomowoc, Wisconsin, United States, 53066
|Green Bay Oncology - Oconto Falls
|Oconto Falls, Wisconsin, United States, 54154
|Ascension Saint Mary's Hospital
|Rhinelander, Wisconsin, United States, 54501
|Marshfield Clinic-Rice Lake Center
|Rice Lake, Wisconsin, United States, 54868
|Ascension Saint Michael's Hospital
|Stevens Point, Wisconsin, United States, 54481
|Saint Michael's Hospital
|Stevens Point, Wisconsin, United States, 54481
|Green Bay Oncology - Sturgeon Bay
|Sturgeon Bay, Wisconsin, United States, 54235
|Aurora Medical Center in Summit
|Summit, Wisconsin, United States, 53066
|ProHealth Waukesha Memorial Hospital
|Waukesha, Wisconsin, United States, 53188
|Aurora Cancer Care-Milwaukee West
|Wauwatosa, Wisconsin, United States, 53226
|Marshfield Clinic - Weston Center
|Weston, Wisconsin, United States, 54476
|Marshfield Clinic - Wisconsin Rapids Center
|Wisconsin Rapids, Wisconsin, United States, 54494
|Canada, Alberta
|Tom Baker Cancer Centre
|Calgary, Alberta, Canada, T2N 4N2
|Canada, British Columbia
|Clinical Research Unit at Vancouver Coastal Health Authority
|Vancouver, British Columbia, Canada, V5Z 3P1
|Canada, Manitoba
|CancerCare Manitoba
|Winnipeg, Manitoba, Canada, R3E 0V9
|Canada, New Brunswick
|The Moncton Hospital
|Moncton, New Brunswick, Canada, E1C 6Z8
|Atlantic Health Sciences Corporation-Saint John Regional Hospital
|Saint John, New Brunswick, Canada, E2L 4L2
|Canada, Nova Scotia
|QEII Health Sciences Centre/Nova Scotia Health Authority
|Halifax, Nova Scotia, Canada, B3H 2Y9
|Canada, Ontario
|Juravinski Cancer Centre at Hamilton Health Sciences
|Hamilton, Ontario, Canada, L8V 5C2
|Odette Cancer Centre- Sunnybrook Health Sciences Centre
|Toronto, Ontario, Canada, M4N 3M5
|University Health Network-Princess Margaret Hospital
|Toronto, Ontario, Canada, M5G 2M9
|Canada, Quebec
|CSSS Champlain-Charles Le Moyne
|Greenfield Park, Quebec, Canada, J4V 2H1
|McGill University Department of Oncology
|Montreal, Quebec, Canada, H2W 1S6
|Canada, Saskatchewan
|Allan Blair Cancer Centre
|Regina, Saskatchewan, Canada, S4T 7T1
|Saskatoon Cancer Centre
|Saskatoon, Saskatchewan, Canada, S7N 4H4
|Principal Investigator:
|Mikkael Sekeres
|Southwest Oncology Group
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01522976 History of Changes
|Other Study ID Numbers:
NCI-2012-00242 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
S1117 ( Other Identifier: SWOG )
S1117 ( Other Identifier: CTEP )
U10CA180888 ( U.S. NIH Grant/Contract )
U10CA032102 ( U.S. NIH Grant/Contract )
|First Posted:
|February 1, 2012 Key Record Dates
|Results First Posted:
|March 22, 2016
|Last Update Posted:
|December 17, 2018
|Last Verified:
|July 2018
Additional relevant MeSH terms:
Myelodysplastic Syndromes
Leukemia, Myelomonocytic, Acute
Leukemia, Myelomonocytic, Chronic
Leukemia, Myelomonocytic, Juvenile
Anemia, Refractory, with Excess of Blasts
Pathologic Processes
Neoplasms by Histologic Type
Bone Marrow Diseases
Hematologic Diseases
Precancerous Conditions
Leukemia, Myeloid
Myelodysplastic-Myeloproliferative Diseases
Anemia, Refractory
Immunologic Factors
Physiological Effects of Drugs
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Growth Inhibitors
Antineoplastic Agents


text:
Photo session in modern or traditional décors and access to a variety of high quality personalized products.
Family, baby, or mommy-to-be photoshoot in a covered garden with different setting styles or interior studio
Photo package with a portrait printed in different sizes including one large 10 x 13 and a hi-res version provided on CD
Personalize these books with an unlimited number of photos per page, a cover photo and a template from a wide selection available
These 28-page calendars are completely personalizable with images, text, backgrounds and colours
Customizable books with an unlimited number of photos per page, a cover photo and a template from a wide selection available
Personalize these books with unlimited photos per page, a cover photo and a template from a wide range available
These photobooks are printed on glossy paper, to keep memories and share your favourite photos
Personalize your photo mugs, for it is always better to have coffee or tea with your loved ones
These customized decorative objects give personality to one's living or working space; unique gifts for loved ones
Fun square pillows customized with favourite photos and choice of text that make great gifts for loved ones
The greeting cards are personalized with your favourite photos and a thoughtful message to feel the joy of sending letters in the mail again
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subset: commoncrawl


text:
South Dakota State Loses Basketball Assistant Coach Austin Hansen
One of Scott Nagy's top assistants at South Dakota State is leaving the school after five seasons on the coaching staff.
Assistant coach Austin Hansen is departing Brookings for an assistant coaching job at Northern Colorado.
In a school press release, Hansen said:
I appreciate the opportunity coach Nagy and South Dakota State gave me to be a part of this program for five years.
I'm very grateful to have coached a tremendous group of guys that have worked hard to achieve a very high level of success for SDSU basketball.
The efforts of these guys have provided me with this new opportunity, and I couldn't be more thankful to them. I wish them nothing but the best for continued success.
Hansen is a South Dakota native, winning the Mr. Basketball award his senior season at Brandon Valley High School in 1998, before playing for Nagy in Brookings from 1999-2003, becoming the first Jackrabbit to lead the team in scoring all four years.
He joined the SDSU coaching staff in 2008 after five years on the staff at Minnesota State in Mankato. In the same press release, Nagy said:
I can't express enough how much I appreciate Austin and the job he did for us.
If you track the progression of our team since he came here, you can easily see how important he has been to our program.
It's very difficult for me to let him go, but I know he wants to stretch his boundaries, so I wish him nothing but the best.
He is a tremendous coach and has a great future.
Hansen will always be remembered by Jackrabbit fans as the man who recruited Nate Wolters to come Brookings out of St. Cloud.
The school plans a national search for Hansen's replacement.


text:
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Expenditure on Works Machinery and Rolling Stock Programme
Important open line works costing more than Rs 20 lakhs each 5973
Passenger and other Railway Users Amenities 7475
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1959-60 Revised Estimate ad valorem additional agricultural Amendment amount of income-tax assessment Budget Estimate Capital Outlay cent Central Government Certificates Chittaranjan Locomotive clause Colombo Plan Consolidated Fund Corporation crores Debt Defence Services deficit Delhi Demand Deposits Depreciation Reserve Development Fund dividends Earnings Electric excise duty expendi export foodgrains foreign exchange FUND OF INDIA Grants Head of Account Himachal Pradesh Imperial gallon Income-tax Act increase Index Numbers Indian company industrial Integral Coach Factory interest on balance investment Item lakhs of rupees lakhs on account levy loans Lok Sabha mainly Manipur ment Ministry Ministry of Steel Miscellaneous Departments motor National naye paise payable payment Posts and Telegraphs production proposed provision Railway reduction Reserve Bank respect Rolling Stock Savings Schedule Schemes section 18 Sub-clause sub-items sub-section surcharge for purposes thousands of Rupees tion total income traffic Tripura ture valorem Voted yard


text:
Trademark Carla Martell "Christmas Party Cat" Gallery-Wrapped Canvas Art, 35" x 35"
Item #: 901-1445367TMG
Model #: ALI0506-C3535GG
Brand: Trademark
Not yet rated.Be the first to Write a Review!
$91.99 Each
Delivery Date:
Enter Zip CodeParcel
Help with furniture delivery, assembly,...Read more + Read less -
protection plans and more.
Plus, you've got choices! You'll find options for those DIYers on a budget, those that want us to do all the work and everyone in-between. Want all the details? Get them right here.
Trademark "Christmas Party Cat" Gallery-wrapped canvas art measuring 35" x 35" with a beautiful design allows for a frameless display on your wall and is created by Carla Martell. Trademark "Christmas Party Cat" Gallery-wrapped art by Carla Martell features a beautiful giclee printed design. 35" x 35" Graphic illustration art hides the wooden frame with canvas enveloped around for an elegant appearance.
- 35" x 35"
- Christmas Party Cat gallery-wrapped canvas art
- Carla Martell
- Subject: Children's art
- Style: Graphic illustration
- Format: Square
- Material: Canvas
- Print medium: Giclee
- Ready to hang
- Features two kids riding a bike downhill
|Art Material : Canvas Art
|Art Type : Canvas Art
|Art Subject : Christmas Party Cat
|Display Covering Material : Canvas
|Brand : Trademark
|Customizable : No
|Weight : 9.00 lbs. per Each


text:
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SAN FRANCISCO (MarketWatch) -- Zynga Inc. saw its battered stock take another spill Thursday afternoon after the company issued a filing showing some changes to its relationship with Facebook Inc. -- among them that the social network will be able to develop its own games if it chooses to. Zynga ZNGA, -0.83% shares slid more than 12% to $2.30 in after-hours trades. In the filing, Zynga said it is no longer obligated to use Facebook's FB, -1.58% credits system to handle payments for games offered on its own Zynga.com platform. But any of Zynga's games offered on that platform - with a few exceptions - must be offered on Facebook as well. "In addition, effective on March 31, 2013, certain provisions related to web and mobile growth targets and schedules will no longer be applicable and Facebook will no longer be prohibited from developing its own games," the filing read.
Have breaking news sent to your inbox. Subscribe to MarketWatch's free Bulletin emails. Sign up here.


text:
- 8 oz. Short pasta (penne, rigatoni, or bow-tie), cooked according to package directions minus 2 minutes
- 1 Winter squash, peeled and diced
- 2 tbs. Extra virgin olive oil
- Pinch of saffron
- ½ c. Dry white wine
- ½ c. Clams in clam juice
- 2-3 tbs. Fresh basil, chopped
1. In a medium pan, sauté the winter squash in the olive oil until golden brown.
2. Add your saffron and deglaze the pan with the dry white wine.
3. Add clams in clam juice and reduce liquid by half. Add the pasta drained pasta and finish to cook inside the sauce until the liquid has thickened and the pasta is nicely coated with the bright yellow sauce.
4. Finish with the handful of fresh chopped basil. Serve warm.


text:
Pacific Gas & Electric has gotten a lot of pushback on their automated "smart meters" that use RF technology to wirelessly transmit gas and electricity usage.
The San Francisco Public Utilities Commission (the water utility), by contrast, has gotten almost no objection to their installation of water meters that use similar technology. Why?
Here are some possibilities:
- People are incredibly irrational.
- People directed their loathing and anger towards PG&E smart meters because it was the easiest and most visible way to object to a company that is deeply distrusted in the bay area, even if you really weren't worried about the health effects.
- The SFPUC water meters are much less visible – out of sight, out of mind?
As a real estate agent I can absolutely confirm that the first bullet point is true. As for the next two items, your guess is probably as good as mine.
The water meters are much less visible – as you can see from the picture above, they actually look far more terrifying than the PG&E meters because they have a bunch of goofy looking cables that run between the meter and the transmitter (which is affixed to the bottom of the utility cover, normally found in the sidewalk in front of your home).
As to whether people like SFPUC more than PG&E, I'd say that's a toss up. Plenty of people in SF would love to see the Hetch Hetchy dam (owned by SFPUC) destroyed and the canyon restored. On the flip side, though, it wasn't the SFPUC that blew up a suburban neighborhood because inspecting their gas pipes on a regular basis was too much work.
What are your thoughts? Conspiracy theorists, be sure to leave a comment!


text:
Man blows off both hands with fireworks
Man blows off both hands with fireworks
SAN JOSE, Calif. —
Police in Northern California say a man igniting illegal fireworks blew off both of his hands when the device exploded prematurely.
Officer Albert Morales of the San Jose Police Department said the man in his 40s is expected to live, but late on Friday's July 4th holiday, the explosive went off in his hands as family members stood nearby.
The San Jose Mercury News also reports Sunday that two other men were seriously injured Friday in Sunnyvale while holding a mortar-like explosive and trying to light it.
The newspaper reports the men were ages 41 and 42. One man lost fingers on his left hand and finger tips on the right hand, while the second man lost part of his right hand.


text:
Kanye West Debuts New Rhymes From His Upcoming Album "Good Ass Job" At The Facebook Headquarters! [Acapella]
Kanye West @ Facebook Headquarters...
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text:
Style # 206872
Luxury chenille fabric, studded bebe logo and casual-chic scoop neckline and 3/4 sleeves make this bebe top a pretty way to show off your love.
- 100% polyester.
- Center back to hem: 23" (58 cm).
- Sleeve length: 18" (46 cm).
- Rhinestone logo.
- Hand wash.
- Imported.
- Model is 5'9" and is wearing a US size S.
Logo 3/4 Sleeve Chenille Top is rated out of 5 by 2.
Rated 5 out of 5 by thott from LOVE the Chenille Sweater! LOVE these Chenille Sweaters. So soft & Comfy. I have purchased one in every Color available because I love the material so much!
Date published: 2012-12-13
Rated 5 out of 5 by Redheaded from Really comfortable and cute top This top is really a pretty color pink. It is a very vibrant color and the material is so soft. I loved it so much I also bought it in white. The size is true to size and it does have a stretch to it. You will really love this sweater top.
Date published: 2012-11-25


text:
[BREAKING] George Zimmerman Granted Bond
A judge has granted a $150,000 bond with restrictions for George Zimmerman who is accused of shooting 17-year-old Trayvon Martin. Moments before the bond was announced by the judge, Zimmerman apologized for the death of Trayvon.
Zimmerman said to the Martin family:
I wanted to say I am sorry for the loss of your son. I did not know how old he was. I thought he was a little bit older than I am, and I did not know if he was armed or not.
The restrictions to Zimmerman's bond include GPS monitoring, no weapons, and no contact with the victim's family. The prosecution had asked the judge for a $1 million bond. Zimmerman will not be released today, but will await trial outside of jail.


text:
St. Augustine Beach is considering an ordinance that would make it illegal to discriminate based on sexual orientation when it comes to housing.
In St. Augustine -- the city next door -- John Gallagher and his partner Tim Millbern own and operate At Journey's End, a bed and breakfast.
"We wouldn't have come to St. Augustine if we thought they weren't gay friendly," Gallagher said Tuesday.
Their B&B is gay-friendly and they welcome all people.
Gallagher learned about St. Augustine Beach's proposed ordinance to make it illegal to discriminate based on sexual orientation when it comes to renting or buying a home. He said, "I think it's about time!"
St. Augustine just passed a similar ordinance last year, and that's what spurred the St. Augustine Beach city commission to consider it, according to city documents.
A similar ordinance failed in Jacksonville.
A chunk of the economies in St. Augustine and St. Augustine Beach is tourism. The top tourism official in St. Johns County is glad to hear about the proposed ordinance in St. Augustine Beach.
Richard Goldman is the Executive Director of the St. Augustine, Ponte Vedra, and the Beaches Visitors and Convention Bureau. He said, "The truth is that any city or entity that says we're accepting of any group of people is good for tourism because it makes people feel comfortable and welcomed... and that's consistent with what we do."
From the welcome sign on the front porch to the freshly baked cookies in the kitchen, Gallagher believes in making people feel welcomed too.
He thinks St. Augustine benefits from its ban on sexual orientation discrimination, and that the city next door will as well.
"I think if a place is great to visit anyone will come," Gallagher noted, "but a group does not want to come here if they feel odd." He added, "They want to be included."
The St. Augustine Beach city commission will take up the proposed ordinance Feb. 4.


text:
Help ESA to name Europe's next mission to Space Station
Now that Paolo Nespoli has returned from the International Space Station, we are looking forward to Europe's next mission. André Kuipers will be launched to the orbital outpost in November – but his mission still has no name. Help us to find a good one!
This will be André's second mission to the Space Station: he made an 11-day visit in 2004 as part of a crew rotation flight. But this time he will be staying for about six months, as a flight engineer on Expeditions 30 and 31. He will see the complex in its full glory – in 2004 it had just three main modules.
He will perform an extensive programme of scientific experiments and take part in several educational activities, in addition to an engineer's operational duties.
DELTA last time, but now?
On his first trip, André's mission patch was inspired by the style of famous artist Piet Mondrian.
The DELTA name stood for 'Dutch Expedition for Life Science, Technology and Atmospheric Research', and also referred to the Dutch Delta Works that protect the low-lying land from the ravages of the North Sea during storms.
Something more broadly European is now required, preferably linked to the environment, climate and biodiversity.
André is an ambassador of the World Wildlife Fund and an emphasis of his mission will be on taking care of Earth and its inhabitants, and how space can help.
He is also a medical doctor, and this might inspire ideas for a name and logo leaning towards health and biology.
Europe is looking towards the Moon, Mars and other bodies in the Solar System, and the International Space Station – with the Columbus laboratory and Cupola observation module both 'made in Europe' – is a unique place to look down to Earth, leap into deeper space and study the Universe.
There are countless possibilities for naming André's mission. You choose!
What to do
Send your proposal to email@example.com by 18:00 CEST (16:00 GMT) on 30 June 2011.
Before sending, please read the instructions carefully.
The competition is open to all citizens or residents of ESA's Member States (see linked instructions). The winning name will become the official European name of André's mission and the winner will receive a framed mission logo signed by European astronauts.


text:
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Air Force Airman Elaina L. Hargreaves graduated from basic military training at Lackland Air Force Base, San Antonio, Texas.
The airman completed an intensive, eight-week program that included training in military discipline and studies, Air Force core values, physical fitness, and basic warfare principles and skills.
Airmen who complete basic training earn four credits toward an associate in applied science degree through the Community College of the Air Force.
Hargreaves is the daughter of Sophia Hopkins of Fruitland, Idaho. She is a 2003 graduate of Hood River Valley High School.
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It's time to set up for the 2017 Scrap Quilt so I'm moving the info from the 2016 scrap quilt challenge page here so I don't lose all the info and you can all still find all the goodness that happened in 2016! Details for the 2017 Scrap Quilt Challenge are coming soon!
Our 2016 Designer Showcase!
On the 15th of the month for 10 months a different designer will be featured! They'll be sharing with you a fun block and/or tip or trick for using up your scraps! I hope you enjoy!
- January 15th: Kim Lapacek, Persimon Dreams - Improv Houses and Trees
- February 15th: Melissa Dunworth, Sew Bittersweet Designs - Improv Curve Piecing
- March 15th: Celine Perkins, Perkin's Dry Goods - Let's Talk Scraps!
- April 15th: Scraptastic - Quilt Show Inspirations
- May 15th: Scott Hansen, Blue Nickel Studio - Scrappy Fish
- June 15th: Christa Watson, Christa Quilts - Controlled Scrappy
- July 15th: Frank Palmer, Full Frontal Quilts - No Leftovers
- August 15th: Mandy Leins, Mandalei Quilts - uncommon neutrals
- September 15th: Pat Sloan, the Voice of Quilting - Scrappy Courthouse
- October 15th: Robin Koehler, Nestlings by Robin - Using Leftovers
WE HAVE AMAZING SPONSORS!!!!See the blog post HERE for all the details!
Designer Scrap Bags!
- Teri Lucas
- Flaun Cline, I Plead Quilty,
- Misty Cole
- Frank Palmer, Full Frontal Quilts (bundle of hand-dyes!!!)
- Joan Ford, Hummingbird Highway
- Maddie Kertay, Bad Ass Quilter's Society
- Kim Lapacek, Persimon Dreams
- Sam Hunter, Hunter's Design Studio - *Bonus* Pattern of Your Choice included!
- Jennifer Jangles
Quilter's Dream Batting
Sew Forever Quilting
Bungalow Quilting and Yarn
The Quilty Box


text:
Arguably the most popular form of online media is YouTube. The website receives over 800 millions unique views per month. It has become synonymous with entertainment. While the origins of the site came from (and continue to be) user-generated video content from the average person, many television stations, major record labels and celebrities have also signed up and upload content. YouTube has certainly evolved from its humble beginnings, not least due to the Google take over in 2006.
First video ever uploaded to YouTube
So where does that leave television? To date you could argue that YouTube doesn't have the same production value as television and so is viewed as its amateur counterpart, but even that cannot be counted on. Especially with the launch of the Partners Programme which allows users to make money from uploading content. As a result the demand for quality content increases and often users employ production teams, camera crew, etc. Making them equal partners with their television comrades.
However the main difference that sets YouTube and television apart is the level of interactivity found in YouTube. Watching shows is no longer a passive activity, viewers are invited to leave comments, like videos, share videos and post video responses. The ability to easily share content with friends has also helped its popularity. It is very straight forward to share videos from your favourite YouTube channels with the click of the button. Yes you can tell a friend about a great show you've seen on television, but as we all know, you risk the possibility of forgetting to look it up, or tuning in a day late and now you've missed it. YouTube can be so easily shared via social networking sites, email, mobile apps and it is available on demand, ready when you are. Once you have an account with YouTube you can also "subscribe" to the channel's of users you like and receive notification of new uploads from those specific channels.
Smosh: the most subscribed YouTube Channel
Through another of YouTube programmes, the $100 million original channel iniative, a brother duo The Fine Bros, who were responsible for many YouTube series over the last number of years, created a brand new type of interactive YouTube series, MyMusic. They set about producing a show with the production value of a regular television series which was released every Sunday, but they took it one step further by releasing further videos throughout the week covering entertainment news, questions from viewers/subscribers and many forms of interactive media. The sub-shows were largely made up of the content submitted by viewers/subscribers in the form of questions, art, captions, voicemails, playlists and polls. It took interactive media to the next level being the first show of its kind on YouTube and has now opened doors for others to follow in their footsteps.
Episode 1 (sitcom version) of MyMusic
Another integral evolution of YouTube is the concept of a video going viral. There have been many examples of this over the years with Nyan Cat, Leave Britney Alone and Carly Rae Jepson. Another YouTube phenomenon was RickRolling, which mislead viewers about the nature of a link, only to be lead to Rick Astley's music video for "Never Gonna Give You Up". Most notable of all viral videos and all content ever uploaded on YouTube has to be Psy - Gangnam Style, which was the first YouTube video to ever reach over 1 billion views. Which shows the scale and magnitude we are dealing with. Other sites such as Facebook and Twitter have helped to promote YouTube content over the years and continue to contribute to the popularity of viral videos.
This new age of media content goes beyond anything that television can offer. So how can it truly compete? In short, I don't think that it can. YouTube has revolutionised how we think about entertainment for the better in my opinion, it has opened the doors to some of the most unlikely content and amazingly different shows from all corners of the globe.
What do you think, can television compete? Do you spend more time watching YouTube shows or television shows?


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Install Virtualbox Guest Additions in Precise Puppy 5.4
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[12 Posts]
Joined: 21 Apr 2010
Posts: 136
Location: Texas
Posted: Wed 24 Oct 2012, 15:53
Post subject:
Install Virtualbox Guest Additions in Precise Puppy 5.4
I use Virtualbox in Windows to test Puppy and create my Kiosk Setup CD. At least in Precise Puppy 5.4 I was unable to get xorgwizard to work. I always had to default to vesa. That is not acceptable as I can not disable the Ctrl+Alt+Backspace and Ctrl+Alt+Fn key combos when using vesa.
Use Precise Puppy 5.4.2 as it includes improvements on the Puppy Package Manager.
(Puppy Package Manager Updates take a fraction of the time now.)
The simple solution was to do a search in the Puppy Package Manager for "guest additions" and search all of the repositories. One of the Ubuntu repositories contains the VirtualBox Guest Additions package.
Install the Virtualbox Guest Additions via the Puppy Package Manager
Step #1 Open the Puppy Package Manager. Menu->Setup->Puppy Package Manager
Step #2 Click on the Find box and search for "guest additions". It will ask you, if you want to search in the currently selected repository or all of the repositories. Select Search to search All of the Repositories.
Step #3 Click on one of the "virtualbox-guest-additions" entries.
Step #4 Click Examine Dependencies (This will select the other entry as well, because they are dependencies of each other.)
Step #5 Click Download-and-install Selected Packages.
Step #6 Choose your server to download from. I left it as the default.
You should now have the package installed, but you are not done yet.
Actually Install the Virtualbox Guest Additions
Step #1 Open the ROX-Filer File Manager.
Step #2 Click the Up Arrow once and you should be at the / "root" of the filesystem.
Step #3 Navigate to the virtualbox folder with the VBoxGuestAdditions.iso file. /usr/share/virtualbox/
Step #4 Mount the VBoxGuestAdditions.iso file by clicking on it.
Step #5 Click on the "VBoxLinuxAdditions.run" file in the VBoxGuestAdditions.iso file that you mounted.
Run the Xorg Wizard
Step #1 Open the Xorg Video Wizard. Menu->Setup->Xorg Video Wizard
Step #2 Start the Xorg Wizard by clicking on the wand icon in the Xorg Wizard box.
You should now be able to click probe and successfully select the correct resolution for your monitor.
Last edited by shadower_sc on Mon 14 Jul 2014, 14:02; edited 2 times in total
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Joined: 13 Dec 2011
Posts: 2
Posted: Sat 27 Oct 2012, 20:33
Post subject:
Thank you so much for your Virtualbox Guest Additions HOWTO. It worked perfectly. I am enjoying running Precise Puppy in Virtualbox on my Macbook with access to the Ubuntu software repositories.
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Joined: 21 Apr 2010
Posts: 136
Location: Texas
Posted: Thu 01 Nov 2012, 10:32
Post subject: Glad it worked.
Glad it worked and I didn't have any typos or steps missing. hehe.
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Joined: 20 Aug 2011
Posts: 872
Posted: Fri 07 Feb 2014, 16:02
Post subject:
any tips on installing for slacko? i cannot find guest additions in the package manager.
i was able to run the iso script, but i got a couple "fails".
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Joined: 10 Sep 2011
Posts: 12591
Location: Mer méditerrannée (1 kms°)
Posted: Sun 16 Mar 2014, 03:52
Post subject: Virtualbox under Puppy linux ?
Subject description: I shall try
Virtualbox under Puppy linux ? that means to will be able to watch other Puppies running ? I will try it at my next free minutes for computing.
I study the subject.
Untill now i have a glance on my Puppies under Windows 7 which is still alive and helpfull beside my linux partition.
I Make a copy of this topic to postit in 'forum francophone', some of my colleagues are interested but not speaking english, I translate it.
Passenger Pelo ! don't ask him to repair the aircraft. Don't use him as a demining dog .... pleeease.
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Joined: 21 Apr 2010
Posts: 136
Location: Texas
Posted: Thu 22 May 2014, 16:17
Post subject: RE: Virtualbox Guest Additions
johnywhy wrote:
any tips on installing for slacko? i cannot find guest additions in the package manager.
A much better solution would be to go to the Virtualbox website and download the correct version of the guest additions cd according to whatever version of Virtualbox you have installed.
Step #1 Check Virtualbox version. Open the Help Menu and click "About Virtualbox ..." and your Virtualbox Version will be shown at the bottom of the pop-up box.
Step #2 Open the following link
Step #3 Click on the link that matches your version of virtualbox.
(I have the version 4.3.12 of Virtualbox, so I would click on the "4.3.12" link/folder.)
Step #4 Click on the VboxGuestAdditions xyz.iso where xyz matches your version of Virtualbox.
(In my case the file was called "VBoxGuestAdditions_4.3.12.iso")
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Joined: 08 Jan 2009
Posts: 43
Posted: Sun 01 Jun 2014, 09:48
Post subject:
but I can not follow since in VirtualBox after loading the live ISO I have problems using my mouse. It seems resolution related. I can only use the mouse over half of the screen then is stops moving as if I hit the boundary.
Even if I set up via keyboard to use VESA or Xorg in 800x600 it is the same.
What can I do so I can properly navigate through puppy loaded in VirtualBox in order to install the guest additions?
thank you
I need only a small ram and hdd footprint Linux with GUi and then Chrome browser...
Thanks alot.
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Joined: 10 Sep 2011
Posts: 12591
Location: Mer méditerrannée (1 kms°)
Posted: Wed 04 Jun 2014, 21:13
Post subject: Virtualbox under Windows or Linux
Virtualbox under
or Linux, please precise.
I use Virtualbox under Windows only for testing my ISOS (in vesa mode when needed ix Xorg not ok).
Install Virtualbox Guest Additions in Precise Puppy 5.4 ?
means install in Windows Virtualbox the Guest Additions for Precise Puppy 5.4 ?
About the mouse problems, verify the size of the allocated memory to Virtual box, i had the same ennoying problem before.
Passenger Pelo ! don't ask him to repair the aircraft. Don't use him as a demining dog .... pleeease.
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Joined: 21 Apr 2010
Posts: 136
Location: Texas
Posted: Thu 26 Jun 2014, 16:37
Post subject: VirtualBox Navigation / Mouse issues with Windows Host
Van78 wrote:
... What can I do so I can properly navigate through puppy loaded in VirtualBox in order to install the guest additions? ...
I had to disable mouse integration for the mouse to work correctly. Either that or run VirtualBox in Fullscreen mode. For some reason it doesn't like sharing the mouse.
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Joined: 21 Apr 2010
Posts: 136
Location: Texas
Posted: Mon 14 Jul 2014, 14:05
Post subject: Re: Virtualbox under Windows or Linux
Pelo wrote:
Virtualbox under
or Linux, please precise.
I modified the first sentence of the first post to be more precise. I use Virtualbox in Windows to work on Puppy Linux.
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Joined: 09 May 2015
Posts: 8
Posted: Fri 15 May 2015, 10:45
Post subject:
I have the same mouse problem on the latest version of VirtualBox on both Windows and Fedora 21 running Puppy Tehrpup 6.0.2.
Also, I was able to select whatever resolution right out of the box but the Virtualbox .run file from the ISO that was installed from the PPM gave me an error that says "Unable to determine correct library path."
Disabling mouse integration worked although I can't find the option to keep it disabled so every time I start the VM I have to disable it or the mouse does crazy stuff.
I had the same problem in Microsoft Hyper-V (although Hyper-V won't let you disable mouse integration, it's a garbage system I don't recommend it). Changing the mouse acceleration settings helped a bit but not 100%.
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Joined: 09 May 2015
Posts: 8
Posted: Fri 15 May 2015, 12:15
Post subject:
A work around I found for the mouse was to disable acceleration by setting the threshold to the highest value. This seems to have made it match up and works quite well now in VirtualBox (doesn't work in Hyper-V but I can't even get an HDD install of Puppy to boot in Hyper-V and even booting the live CD stalls at booting the kernel half the time). I didn't see a setting in Puppy to disable mouse acceleration but that would likely also fix it, if anyone knows how.
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ATC Show in Beijing Attracts 10,000 Attendees
November 7, 2012 by RVBusiness Comments Off on ATC Show in Beijing Attracts 10,000 Attendees
The recent debut of the ATC Show 2012 in Beijing demonstrated the growing RV and camping industry in "China," according to a press release.
Jointly organized by Messe Düsseldorf Shanghai Co. Ltd. and YASN International Exhibition Co. Ltd., the trade fair attracted 242 Chinese and international exhibitors displaying motorhomes, RVs and RV accessories as well campsite management and development companies. Offering 215,200 square feet of exhibit space, the event drew over 10,000 visitors. A wide range of ancillary events, such as forums, conferences and games complemented the exhibits.
Hans Werner Reinhard, deputy managing director of Messe Düsseldorf GmbH and chairman of Messe Düsseldorf China Ltd., commented: "With the first 'All in Caravaning Annual Conference' and the first All in Caravaning show, Messe Düsseldorf has expanded its activities in the Chinese market. I'm very pleased that our company has been part of this debut.We, as the organizers of the No. 1 trade fair for RVs and mobile homes – Caravan Salon International Düsseldorf – will do our utmost to promote our common Chinese activities to the benefit of our exhibitors, visitors and partners."
Reinhard reported that All in Caravaning 2012 was well-received by the exhibitors and the lively atmosphere in the exhibition halls confirmed the growth of the RV industry in China. The target group of RV customers has increased from a few "RV enthusiast" to the general public.
The industry also witnessed considerable developments in infrastructure and the overall quality of industry employees and "companies from the U.S. and Europe showed great interest in entering the Chinese RV market," according to the release.


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Mr. David Miscavige has taken up this subject and the solution provided by L. Ron Hubbard in the booklet, "The Way to Happiness," in several of his speeches:
MR. DAVID MISCAVIGE: "The events of September 11th served as a wake-up call for all of us. When one must worry, in today's modern world, about the safety of its citizens, when one's solutions are limited to the use of military might, it is obvious that the problems we face run much deeper.
"It's a situation none of us can ignore. They are conditions we all must face. They are problems we all must be responsible for helping to resolve.
"Yet look around the world today what will you hear? 'What can I do about it?' 'I'm just me.' And therein lies the real problem. For the truth of the matter is that just 'me' and 'we' are the most powerful force on this Earth.
"And no, I am not merely speaking of the daily headlines of international warfare and conflict. The fact is, that's only but the latest chapter in the drama that has continued to unfold for the past several millennia. War man against man nation against nation. And if today it is different, that's only because the weapons are larger. It's a long way from sticks and stones, to laser-guided missiles.
"But here's the real point. While we are hit with the daily headlines, the Code Orange terror alerts, and all else, it obscures the deeper, more serious problem that underlies it all. Man himself."
(A full audio-visual presentation of the entirety of this 48-minute address can be obtained from the Materials and Services Catalog or can be seen in the Church of Scientology nearest you.)
Keynote Address at the Grand Opening of the Church of Scientology of San Franciscoon the 29th of November 2003
MR.DAVID MISCAVIGE: "In every neighborhood, you can form The Way to Happiness associations to bring common sense morals right to the streets, and Volunteer Minister Chapters to tend to every other of life's problems."
MR. DAVID MISCAVIGE: "But you still have that planetary moral crisis for which LRH [L. Ron Hubbard] wrote The Way to Happiness. It's distributed world over by The Way to Happiness Foundation, and today The Way to Happiness is in more than sixty countries, translated into 27 languages, with a worldwide distribution of more than 54 million copies."
Quelling conflict, world over
Now available in over 90 languages, The Way to Happiness book is not religious and is based wholly on common sense. However, many different religious groups have used The Way to Happiness book as its simple but powerful messages are compatible with and complimentary to most religions of the world.
This book, written by L. Ron Hubbard, successfully bridges cultural, language and religious barriers, and thus our campaigns are comprised of volunteers and supporters from all over the world who are helping people everywhere to live happier, more successful lives and to create a safer, less violent world for all based on these common sense principles and values.
A continual stream of books out into the society is the primary function of the The Way to Happiness campaign. Over the last 24 years 66-million copies of The Way to Happiness book have been distributed worldwide in over 90 languages and in over 100 countries. Tens of thousands of people worldwide are part of the international distribution network that has distributed 66,000,000 books into the hands of mankind.


text:
"The Wire's" Wendell Pierce in Denver
Wendell Pierce, best known for his roles in "The Wire" and "Treme," is also an activist with a great deal to say about the intersection of art and politics.
Pierce will take questions from the audience at CU Denver on Thursday, at 7 p.m. at the Tivoli Turnhall. It's open to the public. I'll be the moderator.
Pierce invested in a chain of convenience stores, Sterling Express, and a full-service grocery store, Sterling Farms, which just opened in a "food desert" in his native New Orleans. The idea is to do well and do good at the same time. More than a store, he says Sterling is a place where "you build that economic engine within your own community and exercise your right of self-determination."
Pierce sees activism as part of the actor's job description. "The role of art is as a forum for the community in the same way you lying awake at night with individual thoughts as a person," Pierce said by phone this week. "Art is that place where we reflect on where we've been, where we hope to go… where we collectively sit down and reflect on our strengths, weaknesses, what are our values, what's meaningful and cherished by us, what's despised by us. Entertainment is just a byproduct."
While in town, Pierce hopes to speak to Mayor Michael Hancock about local opportunities for Sterling Farms (they met at the recent U.S. Mayors' conference in Charlotte.) Ever since Pierce's family lost everything in Hurricane Katrina, he has worked to push his nonprofit development group into under-served communities. "It makes sense economically and has a social impact…You can't get a more clear American aesthetic than that."
Meanwhile, Pierce's acting career remains in high gear. He's cast in a single-camera dramedy for NBC, "The Henrys" with Michael J. Fox, for fall. Fox plays a former local TV anchor with Parkinson's disease in the story partly based on his life. Pierce plays the news director trying to get the M.J. Fox character back on the air. They've worked together before: in 1989's "Casualties of War" with Sean Penn.


text:
Heating & Air Conditioning » Boilers » Lennox Boilers » 80% AFUE
*** Non Induced Draft - Electronic Ignition - Integrated Boiler Control Module - Vent Damper Furnished ***
Here are some of the top features of the GWB8-E:
Electronic ignition control burns fuel only as necessary, reducing energy costs.
Cast iron heat exchanger designed for long-lasting durability.
Easy integration with traditional radiator systems to provide precise heating comfort, regardless of outdoor temperatures.
We Match. You Save.
Found a price that beats ours? We'll match it, guaranteed.
How do you do it?
Step #1: Find the Ad, Copy the URL
When you find a lower price, save the web page URL. You'll need it to get your discount.
Step #2: Use the Price Match Request Form
You'll see a form at the bottom of this page. Paste the full web page URL into the appropriate slot, fill out the rest of the information, and send it to us.
Step #3: Profit!!!
Enjoy your savings, you wiley scoundrel.
What's in it for us?
We love you, and we want your business. We don't want you to run off with some other online retailer, so we're, of course, willing to give you the same deal they are. Plus, in the end, our deal will be way better than theirs! We'll match their price while we deliver life-of-product technical support, real customer service, and free shipping.
More Technical Details
To qualify for a Price Match, you must be able to produce a published price from a legitimate online retailer. Hearing about a 'great deal' from your cousin's neighbor's best friend does not count. The retailer in question will also need to have the product in stock and ready to ship. If it's on backorder, that's a mulligan. You get one claim per product, and cannot use the Price Match Policy in conjunction with other coupons, discounts, Labor Day (or other holiday) sales, or Voodoo magic. Typos, mail in rebates, closeout sales, and other non-standard retail transactions don't count either. Also, finding a great deal on Ebay or another auction site doesn't work.
Basically, the competing price must be for the same product, brand new, factory-sealed, style, model, etc etc. We also reserve the right to deny the IWAE Price Match Policy to anyone who we think is trying to get one over on us and/or trade us a wooden nickel.
Request Price Match


text:
Machine Gun McCain (US - BD RA)
Gabe will have the Ennio Morricone theme song in his head for weeks...
After serving 12 long years behind bars for armed robbery, tough guy Hank McCain (John Cassavetes) finds himself the pawn of a ruthless mob runt's rebellion against a high level don. When McCain discovers that he's been betrayed and abandoned by his new employer, he retaliates with a high stakes Las Vegas casino heist that erupts into a chase and battle through the streets of Los Angeles, San Francisco and New York. Not blood, nor lust, nor wedding vows can come between McCain and his money...or his machine gun.
The Italian gangster films of the 1960s and '70s, also known as Eurocrime, or Poliziotteschi genre, regrettably sit outside the average scope of my knowledge base, so I'm unable to squeeze out another long, boring genre specific essay, as is my M.O. for most Blue Underground's Blu-ray releases. Sorry guys. Anyway, Machine Gun McCain is actually a good place for a relatively uninitiated viewer like myself to work from. Director Giuliano Montaldo (who also directed Blue Underground favourite Grand Slam) embraces the swinging '60s with relish, creating an atmosphere Bullitt, Bond, and Walker would all feel perfectly comfortable walking through. Though this obviously dates the production, it also sets it apart from many similar Eurocrime releases, and is generally visually interesting. Montaldo isn't a particularly flashy director, but he has a solid control over the widescreen frame, gets good use out of the era images, and clearly studied John Boorman's work on Point Blank (the seminal, non-Bond staring crime flick of the 1960s, in my opinion). Montaldo also efficiently sets up McCain's heist plans as well, without ever depending on dialogue to explain anything unnecessary, and cuts a mean montage when called upon. I hear Grand Slam is a more solid representation of this skills, and a generally more stylized film, but I haven't gotten around to that one yet.
The script, which is co-written by Montaldo, is better than average, featuring interlacing plots, and just enough intrigue to sell the relatively routine storyline. The use of an occasional narrator is the only particularly ham-handed storytelling element, save a few less than impressive lines of dialogue. The cast is especially extraordinary, more so than I'm used to expecting from era Italian thrillers. The casting appears to up the production values, but at the time most of these actors were relatively unknown, or at least not particularly famous. The exception is star John Cassavetes, who had already developed quite a name for himself with his transitional work in the director's chair here in America. Cassavetes was known for taking whatever acting jobs he could get to finance his films, so the effort he puts into the roll is actually quite satisfying. Cassavetes brought his wife (widow) Gena Rowlands onto the project, but the remaining names apparently came on to the project for the work. These include future Columbo Peter Falk, future Bond Girl, and Wicker Man dancing lady Britt Ekland, and Italian all-stars Gabriele Ferzetti ( Once Upon a Time in the West, On Her Majesty's Secret Service, The Night Porter), Luigi Pistilli ( For a Few Dollars More, The Good, the Bad and the Ugly), and Fulci favourite Florinda Bolkan ( A Lizard in a Woman's Skin, Don't Torture a Duckling).
Blue Underground is in fine form here with this 2.35:1, 1080p transfer. It's not impossibly good looking, but the overall image quality is about as perfect as a film from 1969 can be expected to look without regular upkeep over the years. I don't have a DVD version for comparison, but am guessing colour clarity, and detail levels barely compare between transfers. Machine Gun McCain isn't too flashy, but the late '70s mod style presses the palette into some pretty bright arenas. Skin tones are natural, as are skies and outdoor vegetation, but the primary hue saturated costumes, cars, and interiors Shots of the Vegas strip are especially impressive, displaying a rainbow of hues brightly, and sharply lit against deep, clean blacks. Some of the darker interiors lead to bleeding blues, softer edges, and a loss of detail, but grain plays a relatively consistent roll throughout. The film shakes a bit (which is probably the most distracting issue), and I caught some hard to miss pieces of minor print damage, but on the whole this is a pretty clean transfer, certainly considering the source's age and relative obscurity. These problems are so underwhelming overall that stock city shots actually stick out quite a bit, which is quite the compliment.
There appear to be a few frames missing from the print here and there, and most of them pertain to violence, but no clearly deleted sequences. I'm not sure if this is a cut print or not, but my violence-sense is tingling…
Machine Gun McCain makes its American video debut with a no frills, uncompressed DTS-HD Master Audio 1.0 mono soundtrack. Like most period Italian productions it's likely the entire film was shot without sound, and it's just as likely that certain actors are speaking Italian or some other language, so occasionally mis-synced vocals, and different aural qualities are excusable. Higher volume vocals (usually Peter Falk) exhibit quite a bit of distortion, and most of the basic foley is tinny, but these have likely been inherent issues since the film's initial release. The big audio moments, such as car scenes, suffer a bit from the flattening, and lack of LFE support, but are still sonically successful. The only reason to lament the lack of 5.1 enhancement is Ennio Morricone's score is flattened to a solitary channel (I have CD versions of the recordings that really benefit from the stereo separation). Morricone mixes his jazz-infused Giallo work with his Spaghetti Western work, both of which served as the composer's bread and butter throughout the '60s and '70s, and includes some amusing lyrics over the end credit theme that will drill themselves into your brain like a cancer.
The rather sparse extras begin with an interview with director/co-writer Giuliano Montaldo (22:40, SD). In proper Blue Underground tradition Montaldo runs through most of his career, putting emphasis on Machine Gun McCain and Grand Slam (which Blue Underground released on DVD several years ago). Discussion includes his love of simple direction, his work with American actors and settings (permits, etc), the McCain production process, and the difference between his film's and their Hollywood counterparts. The extras also include the English and Italian trailers.
As stated, I'm thinking Machine Gun McCain is a good entry point for those of us uninitiated in the ways of Eurocrime, or Poliziotteschi genre films. It's stylish without flash, efficient without stupidity, and features a very impressive cast, including art film demigod John Cassevetes, and a pre- Columbo Peter Falk. The new 2.35:1, 1080p transfer looks better than it should, thanks to the super high standards at Blue Underground, and the DTS-HD 1.0 soundtrack does its job effectively enough. Extras are brief, but the director's interview is informative enough to fill in a few behind-the-scenes blanks.
* Note: The above images are taken from the Blu-ray release and resized for the page. Full-resolution captures are available by clicking individual images, but due to .jpg compression they are not necessarily representative of the quality of the transfer. Thanks to Troy at Andersonvision.com for the screen-caps.
Review by Gabriel Powers
This product has not been rated
Disc Details
Release Date: 24th August 2010
Discs: 1
Disc Type: Blu-ray Disc
RCE: No
Video: 1080p
Aspect: 2.35:1
Anamorphic: No
Colour: Yes
Audio: DTS-HD Master Audio 1.0 English
Subtitles: English SDH, French, Spanish
Extras: Director Interview, English Trailer, Italian Trailer
Easter Egg: No
Feature Details
Director: Giuliano Montaldo
Cast: John Cassavetes, Britt Ekland, Peter Falk, Gena Rowlands, Luigi Pistilli, Florinda Bolkan
Genre: Crime
Length: 96 minutes
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The No. 11 Saint Thomas More Preparatory girls soccer team upset No. 6 Appoquinimink High School in the first round of the DIAA state tournament.
If one were to look at every stat that came out of the first round game in the DIAA girls soccer state tournament between No. 6 Appoquinimink High School and No. 11 Saint Thomas More Preparatory, final score excluded, it'd be easy to assume that Appoquinimink was celebrating a victory after the May 23 contest.
Not so.
Despite bombarding the Ravens defense with shot after shot throughout the game, which was played at Appoquinimink High School, the Jaguars could not find the back of the cage Wednesday night.
The Ravens, on the other hand, had scoring opportunities that were very few and very far between. But, as it often goes in the tournament, it only took one goal, a goal that came off the foot of sophomore Alexa Schimp in the 70th minute of the game. It was a goal that Head Coach Josh Katz said looked like it was in slow motion.
And it ended up being the only goal Saint Thomas would need, as it won 1-0 and earned a chance to play No. 3 Caesar Rodney High School in the second round on Saturday, May 26.
"That was one of the gutsiest performances this team has ever put up," Katz said. "Tom come to Appo and play them with the way they played the whole game, it was just a gutsy performance."
Schimp, who scored her goal after running about 30 yards with a defender draped on her, and then shooting off balance, said the win by her team just shows the resolve the group of girls has.
"We all have a lot of heart," she said. "We just don't stop pushing until it's done. We just want it so bad."
While the Raven sideline was one of jubilation, shock and surprise at what they'd just accomplished, the Jaguars sat, heads down, wondering what else they could have done in a game they essentially controlled from the outset.
"I do think we outplayed them and dominated most of the game," Appoquinimink Head Coach Christine Serin said. "It definitely wasn't a lack of opportunity. It just didn't seem to work. I really think that the girls played hard the entire 80 minutes, and that's all we can ask for. This is going to be a tough loss for us."


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Police have released a CCTV image of a 'Good Samaritan' who helped a woman with facial images.
Police are appealing for a passer-by who helped a woman with facial injuries after spotting her in the street to come forward.
The Good Samaritan was driving along Clifton Road, Matlock Bath, when she stopped to help the victim, who had several injuries to her face.
She took the victim to Whitworth Hospital, in Darley Dale, and left her in the care of nursing staff before leaving.
The incident took place at about 7pm on Monday, March 10. The victim was later taken to Chesterfield and North Derbyshire Royal Hospital.
Police have released a CCTV image of the Good Samaritan who picked the victim up and drove her to hospital. Officers want to speak to the woman to help with their inquiries.
Do you recognise the person in the still? Anyone with information should call Derbyshire police on 101, quoting crime reference 10324/14