text:
Brooks Brothers
Gold-plated Coral Sphere-drop Leather Necklace
17" long; imported.
FedEx will deliver items that are available for immediate shipment in 3-7 business days for a standard shipping charge. All orders to Alaska, Hawaii, and Puerto Rico are shipped by air for an additional $10.00 fee per address.
Brooks Brothers wants you to be satisfied with your merchandise. We will gladly accept a return or exchange of saleable merchandise in original condition within 90 days of purchase date accompanied by an original receipt. All returns accompanied by original receipt will be credited to original form of payment.
Saleable merchandise in original condition not accompanied by a receipt will be accepted and a merchandise credit will be issued for the lowest price. Photo identification is required for all merchandise credits. If your cash return is greater than $200.00 a company issued check* will be mailed to you. Monogrammed and altered merchandise and special order clothing will not be accepted for a return or exchange.
Price adjustments will be made within 10 days of original purchase date with original receipt present. Only items purchased at full price are subject to a price adjustment.
All sample sale and Head of the Charles merchandise purchases are final sale and cannot be returned or exchanged.
*US Only; in Canada, credit to debit card will be issued


text:
May 21. 2013 10:24PM
Suit: Claremont's North Country Smokehouse claims $606,011 spent on diamond, SUV, more
By MEGHAN PIERCE
Union Leader Correspondent
CLAREMONT — North Country Smokehouse filed civil action Friday in Sullivan County Superior Court, alleging office manager Bonnie Johnson embezzled more than $600,000 from the company and spent it on luxury items including a $30,000 diamond ring, motorcycles and Mercedes SUV.
President and owner of the company Michael Satzow discovered the embezzling in late April when Johnson was away on vacation, according to court documents.
"There is a substantial danger the property sought to be attached will be damaged, destroyed, concealed or removed from the state and placed beyond the attachment jurisdiction of the court," an ex parte motion attached to the civil suit says.
According to the motion filed in Sullivan County Superior Court on Friday, Johnson embezzled $606,011.77 using company checks issued fraudulently to herself from 2005 to 2013.
She also spent an unknown amount on a company credit card, according to the court filing.
According to North Country Smokehouse's website, the 101-year-old company sells smoked hams, bacon, turkey, sausages, chicken, duck, brisket and cheese, and is one of the country's last family-owned smokehouses.
The ex parte motion seeks to stop Johnson from selling items allegedly purchased with the money including the diamond ring, SUV and several Harley-Davidson motorcycles and snowmobiles.
Satzow described Johnson as a trusted employee of North Country Smokehouse.
The office manager reported directly to Satzow, and handled all aspects of the company's finances, the court document said.
When contacted, Police Chief Alexander Scott declined to comment on whether there was a police investigation. Sullivan County Attorney Marc Hathaway also would not comment.

subset: commoncrawl


text:
26th October 2005, 05:39 PM
My newest addition, Sophie Rose (age 7), a ruby, seems to have chronic dry eye, so everyone's information is helpful as I've never dealt with this problem before. She also seems to be almost totally deaf - she was imported as a pup from London. I've wondered if this is a very common hereditary condition other cavalier moms have seen? We are just working on some general commands - esp. the "it's time for dinner!" She was re-homed with us last summer from a breeder who wasn't going to use her for breeding anymore. It's a great way to find another little one w/out waiting so long (in the US) for a rescue dog. We couldn't love her more in such a short time! :p


text:
5 Up-and-Comers You Should Find at Design Miami/ Basel
Artsy Editorial
Though both Marc Baroud and Marc Dibeh maintain their own busy architecture and design practices, they join creative forces now and again on collaborative projects. They are both based in Beirut, and they first began working together when Dibeh completed his studies and joined Baroud's studio. With Baroud's encouragement, Dibeh eventually left to strike out on his own. The two have come back together to work on projects like their "WIRES" series. Premised on the flexibility and versatility of a simple steel rod, this series encompasses a whimsical, elegant range of home furnishings, including lamps, tables, desks, and shelving and organization units. These are all structured out of a length of steel, bent into basic geometrical shapes, and then combined with other materials. Through such works, Baroud and Dibeh celebrate and experiment with form without sacrificing function.
Lebanese, based in Beirut, Lebanon


text: /* profile.h - Defines data exported from profile.c to other passes. Copyright (C) 1998, 1999, 2000, 2001 Free Software Foundation, Inc. This file is part of GCC. GCC is free software; you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation; either version 2, or (at your option) any later version. GCC is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details. You should have received a copy of the GNU General Public License along with GCC; see the file COPYING. If not, write to the Free Software Foundation, 59 Temple Place - Suite 330, Boston, MA 02111-1307, USA. */ #ifndef GCC_PROFILE_H #define GCC_PROFILE_H struct profile_info { /* Used by final, for allocating the proper amount of storage for the instrumented arc execution counts. */ int count_instrumented_edges; /* Used by final, for writing correct # of instrumented edges in this function. */ int count_edges_instrumented_now; /* Total count of the number of calls instrumented. */ int count_instrumented_calls; /* Total count of the number of calls instrumented in this function. */ int count_calls_instrumented_now; /* Checksum of the cfg. Used for 'identification' of code. Used by final. */ long current_function_cfg_checksum; /* Max. value of counters in program corresponding to the profile data for the current function. */ gcov_type max_counter_in_program; gcov_type max_call_counter_in_program; /* The number of profiles merged to form the profile data for the current function. */ int count_profiles_merged; }; extern struct profile_info profile_info; extern int need_func_profiler; #endif


text:
Difference between revisions of "Diskless network boot NBD root"
(→Shutdown Hang)
|Line 64:
|Line 64:
====Editing rc.conf====
====Editing rc.conf====
Make sure you set NETWORK_PERSIST="yes" and your own settings in /mnt/etc/rc.conf. Also edit /mnt/etc/locale.gen and make sure your locales are enabled.
Make sure you set NETWORK_PERSIST="yes" and your own settings in /mnt/etc/rc.conf. Also edit /mnt/etc/locale.gen and make sure your locales are enabled.
===Configuring the NBD server===
===Configuring the NBD server===
===PXE/TFTP Setup===
===PXE/TFTP Setup===
|Line 111:
|Line 110:
==Known Problems==
==Known Problems==
===Shutdown Hang===
===Shutdown Hang===
will , to )
Revision as of 09:30, 4 July 2011
- 1 Boot from a NBD root device
- 2 Advantages over NFS
- 3 Server-Side Setup
- 4 Boot Configuration
- 5 Using a Swap Partition
- 6 Updating the Client System
- 7 Known Problems
Boot from a NBD root device
This article will explain how to boot an ArchLinux Installation from a Network Block Device (NBD).
Much of the work to be done is based on the article Diskless network boot NFS root, so this will be referenced several times within the article.
Advantages over NFS
The main advantages are that NBD is faster and that you can boot from an encrypted or LVM-based NBD root device. One disadvantage is that you cannot easily update your kernel from within the running diskless client, although there is a workaround for this.
Server-Side Setup
Create the NBD File and Boot Directory
Create a directory that will hold the boot directory and the NBD file.
mkdir -p /nbd/boot/
Next, create the actual file that will be shared via NBD. Of course you can also use an actual block device (a hard drive) instead of creating a file on your filesystem. Just replace /nbd/root with the block device. In this example we are going to create a file with a size of 5GB.
dd if=/dev/zero of=/nbd/root bs=1M count=5000
Now you can create a filesystem on the file.
mkfs.ext4 /nbd/root
mkfs will show you warning about the fact that the file is no actual block device. You can ignore this and simply press y to continue.
Alternatively, if you want to create an encrypted NBD device:
cryptsetup luksFormat -s 256 /nbd/root cryptsetup luksOpen /nbd/root nbdcrypt mkfs.ext4 /dev/mapper/nbdcrypt
Install ArchLinux on the NBD filesystem
Mount the filesystem:
mount /nbd/root /mnt
Now follow the instructions here, but be aware of three things:
- make sure you use /mnt instead of /disklessroot
- you are going to have to install the mkinitcpio-nbd package from AUR before recreating the kernel image
- the editing of /mnt/etc/mkinitcpio.conf is different for NBD
Installing mkinitcpio-nbd
Editing mkinitcpio.conf
Set the following hook list in /mnt/etc/mkinitcpio.conf:
HOOKS="base udev net nbd filesystems"
If you use an encrypted NBD device, use this:
HOOKS="base udev net nbd usbinput keymap encrypt filesystems"
Then continue with the instructions about recreating the kernel image in the NFS article.
After leaving the chroot, the kernel image will be in /mnt/boot/. We are going to need it in /nbd/boot:
cp /mnt/boot/vmlinuz26 /nbd/boot/ cp /mnt/boot/kernel26.img /nbd/boot/
Editing rc.conf
Make sure you set NETWORK_PERSIST="yes" and your own settings in /mnt/etc/rc.conf. Also edit /mnt/etc/locale.gen and make sure your locales are enabled.
Configuring the NBD server
PXE/TFTP Setup
Follow the instructions here. Just make sure you use /nbd/boot/ instead of /disklessroot/boot/ for the TFTP-Root.
Boot Configuration
Copy the pxelinux.0 boot file from syslinux to /nbd/boot and create the pxelinux.cfg directory:
cp /usr/lib/syslinux/pxelinux.0 /nbd/boot/ mkdir /nbd/boot/pxelinux.cfg/
Now create and edit /nbd/boot/pxelinux.cfg/default, which contains the boot configuration for the client. Replace the value for nbd_server with the IP and Port your NBD server will be running on.
default linux label linux kernel vmlinuz26 append initrd=kernel26.img ip=::::::dhcp nbd_server=192.168.0.1:10809 root=/dev/nbd0
See here for details about the ip option.
If your NBD device is encrypted, use the following append line instead:
append initrd=kernel26.img ip=::::::dhcp nbd_server=192.168.0.1:10809 cryptdevice=/dev/nbd0:nbdcrypt root=/dev/mapper/nbdcrypt
Using a Swap Partition
Although this has not been tested yet, you should be able to do this by creating a LVM volume group on /dev/nbd0 that contains the root and swap partition and adding lvm2 before the filesystems hook in /mnt/etc/mkinitcpio.conf.
Updating the Client System
Quote from the NBD homepage:
"[...] if someone has mounted NBD read/write, you must assure that no one else will have it mounted."
In other words, if you want to be able to update from your client system, you have to make sure that the NBD device is not mounted on any other system, not even read-only. If your NBD device is encrypted, make sure to not just dismount it, but also close it with 'cryptsetup luksClose'. Otherwise, you may break your filesystem. If you keep that in mind, everything except kernel updates should work fine.
Alternatively you can mount the NBD device on the server (again, make sure it is not mounted anywhere else!) and update your system with:
pacman -Syu --root /mnt --dbpath /mnt/var/lib/pacman
Kernel Updates
Since the kernel the client system boots from is on the server and not in the NBD device itself, you will not be able to simply update your kernel with pacman. There are several other ways to do this:
- If you update from the client system:
- share /nbd/boot on the server via NFS, mount it to /boot and then update your kernel
- copy vmlinuz26 and kernel26.img from /boot back to the server to /nbd/boot after the kernel update
- if you update from the server (make sure proc, dev and sys in /mnt are mounted!):
- symlink /nbd/boot to /mnt/boot and then update your kernel
- copy vmlinuz26 and kernel26.img from /mnt/boot to /nbd/boot after the kernel update
Known Problems
Shutdown Hang
(will be removed, moved to discussion)


text:
About Us
Sayulita Weddings is made up of a creative staff with a career in professional event planning and services. Friends that had been working solo in this business since the late 90's decided to join together in 2003 to create Sayulita Weddings as an alternative event planning agency which provides clients the most professional, honest and complete service for events and weddings in the area.
Our team is devoted to create unique weddings for our clients. We believe that each wedding must reflect the couples' passion and love among themselves, their loved ones and life itself. Through a very personal approach we make specific plans for each of the couples we work with.
Allow us to make your wedding dreams come true. Through a personalized attention your event will be superbly organized.
Wedding Coordination
Luz Ochoa has a broad experience in production. She started as a producer doing commercials and video, and moved on to corporate and social events logistic and coordination in Mexico City.
Along with her husband/partner Jorge Angulo, who has been an event producer for more than a decade, and driven by her passion for event production and personalized customer service, she founded in 2000 Vallarta No Problem! a company specialized in logistics and innovative support for events as well as equipment rentals.


text:
FTTH CE: 2017-2018 strategy
|May 10, 2017
|Latest News
|FTTH Council Europe
FTTH Council Europe re-elected Ronan Kelly as President at its GA and set out an ambitious growth strategy to accelerate fibre investment and adoption.
A new Working Committee on Fibre Business Models has been also set up with the aim of contributing to the ongoing policy debate on very high capacity network investments, bringing together expertise from fibre operators, investors and technology innovators.
< back


text:
TRENTON, N.J. (AP) - November 2, 2012 --Efforts to get commuter trains running in New Jersey have suffered a setback and New Jersey Transit won't be able to run as many trains into New York City.
NJ Transit spokesman John Durso Jr. says a backup generator failed overnight at the center in Kearny and couldn't be restarted. Switching equipment was affected.
Service that had been set to restart Friday is suspended on the North Jersey Coast, Raritan and Main lines. Buses will cross-honor rail passes.
But Northeast Corridor service into New York is running.
Special schedules are being posted at New Jersey transit.


text:
John DiStaso's Granite Status: Judge dismisses AG's 'push poll' case against former US Rep. Charlie BassJOHN DISTASO
Senior Political Reporter
June 20. 2013 5:02PM
THURSDAY, JUNE 20: BASS WINS DISMISSAL. A judge has ruled the state's "push poll" law does not apply to candidates for federal office, dismissing a civil suit brought by the state Attorney General's Office against former U.S. Rep. Charlie Bass' campaign committee in the 2010 election.
The Attorney General's Office charged in April 2012 that the Bass Committee violated the law because in poll-style telephone calls the campaign committee cosponsored in September 2010 to provide voters with information about his opponent, current U.S. Rep. Annie Kuster, it deliberately did not disclose that it was one of the entities sponsoring the calls, as the state law requires.
The Bass Committee, through Concord attorney Charles Douglas, argued in court that the calls in question were not "push poll" calls, but rather legitimate public opinion research and message testing.
Douglas also argued that the state has no jurisdiction over how campaigns for federal office are conducted.
Merrimack County Superior Court Judge Richard McNamara agreed that the Federal Election Campaign Act supersedes state law in elections for federal office. He did not address the question of whether the Bass calls were part of a legitimate message testing survey or a true push poll, which is essentially a telephone political advertisement.
McNamara, in an eight-page ruling, cited a Federal Election Commission advisory opinion issued specifically on the Bass case last year at the request of the national polling firm Greenberg Quinlan Rosner.
That FEC opinion said, "The New Hampshire statute requiring disclaimers on certain telephone calls is preempted by the (Federal Election Campaign) Act and (FEC) regulations with respect to the proposed telephone surveys made on behalf of federal candidates, their authorized committees or other federal political committees that refer only to candidates for federal office."
McNamara wrote in his opinion that advisory opinions are not binding, but in this case, "The consistent interpretation of federal law and regulations by those familiar with its enforcement is persuasive.
"Here," wrote McNamara, "the FEC is most familiar with the enforcement of (the federal campaign law) and its reasoning is both persuasive and remarkably consistent."
He wrote that federal law considers such telephone polling only in the context of being a campaign expenditure, and because it addresses such calls, "federal law preempts the state statue."
The Attorney General's Office has the option of seeking reconsideration and appealing the decision to the state Supreme Court.
It is unknown if it will. Officials at the office did not respond to requests for comment.
Douglas said he was pleased by the ruling and credited Bass for challenging the state civil action.
Bass faced potential fines of up to $400,000. But Douglas said, "Charlie just didn't say, 'Oh, I'll pay a fine and move on.' He said, 'No. It's not right. It's wrong to apply this law to federal races and it's going to hurt the New Hampshire Primary if someone doesn't stand on principle here and fight it.' I'm proud of him."
National pollsters had complained that the state law definition a push poll incorrectly covers legitimate opinion research calling. The Market Research Association and the American Association of Political Consultants intervened in the Bass case, supporting Bass' motion to dismiss.
Some national pollsters had warned the state law, and the Attorney General's Office aggressive enforcement of it in recent years, would deter pollsters from becoming involved in the New Hampshire first-in-the-nation primary campaign, and could, as a result, hurt the primary.
They said candidates may be reluctant to campaign in the state if they cannot have their pollsters fully explore voter sentiment on key issues and test messages about themselves and their opponents without fear of being sued by the state..
State legislators, recognizing a problem with the current push poll disclosure law, tried to rewrite the statute in earlier in the current session. But the bill was retained until next year by the House Election Law Committee, which cited too many uncertainties in the bill and said it needed more work.
McNamara's ruling has no effect on the Attorney General's ability to enforce the push poll statute in campaigns for state office, such as governor, Executive Council or the state Legislature. The Federal Election Campaign Act does not apply to state elections.
(For earlier Granite Status reports, click on "Granite Status" above.)


text:
This Week In Island History
The news of 10 and 15 years ago is from the Jamestown Press. The news of 100 years ago came from the collection of the Newport Historical Society.
100 years ago From the Newport Journal, Dec. 26, 1913
The children's Christmas concert at the Central Baptist Church was held Sunday evening. The church was decorated with holly, and the little ones took part in a manner that pleased the audience and showed much care on the part of those who arranged the program.
After the Christmas holidays, the school children, who have been accommodated in the Town Hall, will occupy a part of the new addition to the schoolhouse. It was hoped to have the room on the lower floor ready, but owing to the non-arrival of the partition curtain on the north end, it will not be done until later.
75 years ago From the Newport Daily News, Dec. 27, 1938
Work on the actual construction of the $3,100,000 Jamestown Bridge has been started, it was announced today by the bridge commission, following completion of two days of negotiations between the commission and representatives of the banking interests in Providence. Under the PWA requirements, the work had to start before Dec. 31 this year, and has to be completed by June 1940. Financing of the bridge was completed with representatives of Stranahan, Harris & Co. of New York.
50 years ago From the Newport Daily News, Dec. 26, 1963
Among groups of young people singing Christmas carols in Jamestown at the Harbor View Nursing Home and at numerous other homes in town were the Rainbow Guild and the Senior High Baptist Youth Fellowship of Central Baptist Church.
From the Newport Daily News, Dec. 31, 1963
Jamestown marked 1963 with a victory for the Democrats in the biennial spring election, a civic center study, the adoption of a record budget, a tax raise and the controversial subject of the Lawn Avenue school access road.
25 years ago From the Newport Daily News, Dec. 22, 1988
The Public Utilities Commission Wednesday denied an emergency request by Newport Electric to enlarge its Clarke Street substation.
From the Newport Daily News, Dec. 31, 1988
Tomorrow at noon, more than 350 penguins are expected to barrel into the surf at Mackerel Cove to continue the tradition begun by Mike McGovern and his friends 13 years ago.
15 years ago From the Jamestown Press, Dec. 23, 1998
The Highway Barn Committee voted unanimously Monday to recommend the transfer station site to the Town Council as the preferred location for a new highway barn.
The School Committee unanimously approved the budget for 1999-00 school year, a spending package that reflects a 6.7 percent increase over last year. The budget passed the $6 million mark.
10 years ago From the Jamestown Press, Dec. 24, 2003
Environmentalists this week cited an endangered plant species and an unmapped freshwater spring as new ecological considerations that could mean time-consuming government reviews for the town's new highway barn.


text:
Ooops! You have arrived on a page that does not exist!
It may have been removed or you may have arrived here by using a bad URL
Try searching for the article you are looking for, visit the BizSugar Homepage to see the most recent stories, or use the Sitemap to find what you're looking for.
David Leonhardt: SEO Small Business Writer
Meet David Leonhardt, our most recent BizSugar "Contributor of the Week" on Facebook. It's a little recognition we … MoreMore Contributors
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Ti Roberts
Ti Roberts is an Internet marketer & blogger with over 7 years experience. On her blog, she enjoys teaching her following how to generate traffic via Blogging, Social …


text:
CEE Morning Briefing: Energy and Austerity in Focus
- Local/GMT
- 0700/0600 Polish refiner Grupa Lotos 4Q earnings
- 1300/1030 Hungary 12 month T-bill auction
- 1400/1300 Polish January CPI expectations
- All day Platts CEE Energy conference in Prague
- n/a Hungary PM Orban, Russian President Putin meet in Moscow
- n/a Slovenian parliament fiscal austerity bill debate
Energy and fiscal policy are going to be the dominant issues in the Central and Eastern European region on Thursday.
Hungarian Prime Minister Viktor Orban and Russian President Vladimir Putin meet in Moscow to discuss Hungary's participation in the South Stream pipeline that will transport natural gas from Russia through the Black Sea to Bulgaria and other European Union countries. South Stream is expected to go online in 2015 and eventually deliver gas to Italy, Greece, Hungary and Austria.
In Prague, executives from electricity utilities, power grid operators and other energy companies in the region will meet for a conference on power-trading issues, nuclear energy projects and the EU's carbon emission trading scheme. The event is organized by Platts, a provider of energy commodities data and price quotes.
Slovenia's parliament will debate the government's fiscal-consolidation bill, centered on budget spending and welfare cuts, which is unpopular among Slovenian voters. Two large-scale protests against austerity policies are scheduled for Friday in Ljubljana, the Slovenian capital, and follow last week's anti-government rallies and strikes among public sector employees.
Polish state-controlled oil refiner Grupa Lotos SA made 241.8 million zlotys ($78.2 million) in fourth-quarter net profit, above expectations, in part due to a stronger zloty which reduced the value of its foreign-currency debt.
POLAND: A banking union for euro-zone members is necessary for the survival of the European Union's single currency, Marek Belka, governor of the National Bank of Poland, said Wednesday.
But Poland, which pledged in its EU accession treaty to join the euro, may not find it in its best interest to rush to sign up for the banking union, Mr. Belka said. The most important issue for it to consider is whether the banking union's primary purpose is to prevent euro's crises in the future or to pay back the debts of present members, he said.
HUNGARY: The chief architect of the Hungarian government's unorthodox economic-recovery program said Wednesday that the country's central bank can use more creative monetary measures to boost output without endangering financial stability or igniting inflation.
For the National Bank of Hungary, "there's room to maneuver to foster economic growth," Economy Minister Gyorgy Matolcsy said, while emphasizing that the bank needs to "be extremely cautious" in its actions given the country's high level of foreign-currency debt and the jittery state of the markets.
ROMANIA: Romanian government ministers and elected lawmakers should stop clouding democratic processes with judicial probes where the whiff of corruption remains, the European Commission said Wednesday.
Six years after Romania's accession, the European Union is still struggling to see its easternmost outpost as a natural fit--with Commission President Jose Manuel Barroso repeating "serious concerns" that need addressing with elections keeping President Traian Basescu and arch-rival Prime Minister Victor Ponta locked in a simmering power struggle.
Write to Leos Rousek at firstname.lastname@example.com


text:
My call to clBuildProgram is failing and giving me the following error message in the build log:
Using Device (NVIDIA Corporation : GeForce GTX 260)
Failed to build program executable
ptxas application ptx input, line 133; error : Predicate variable 'sampleKernel_param_6' must be in register state space
: Retrieving binary for 'anonymous_jit_identity', for gpu='sm_13', usage mode=''
My source file contains two kernels and two helper functions. I can provide some of the code if needed but I don't really even know what this error relates to. I tried for a while to search for this error online but couldn't find any information. The line number it is reporting the error at is a call to one of the helper functions but I'm not sure if it actually has anything to do with the error...
Code :sample = complexAdd(sample, scattererContribution);
Code :double2 complexAdd(double2 a, double2 b) { double2 rv; rv.x = a.x + b.x; rv.y = a.y + b.y; return rv; }
I can provide more of my code if necessary but since I didn't know where to begin with this error I didn't know how to narrow down the portion of the code that was incorrect.


text:
A look at boys basketball district tournaments involving area teams.
Class 8A, District 1
When: Tuesday, Friday
Where: Flagler Palm Coast
Matchups: Tuesday -- No. 2 Jacksonville Sandalwood vs. No. 3 Flagler Palm Coast, 7 p.m. Friday -- No. 1 Jacksonville Mandarin vs. Flagler Palm Coast/Jacksonville Sandalwood winner, 7 p.m.
Outlook: Sandalwood enters the tournament on a nine-game winning streak. It's last loss came Jan. 11 to top-seeded Mandarin. FPC has won four of its last six.
Class 8A, District 2
When: Tuesday, Wednesday, Friday, Saturday
Where: Lake Mary
Matchups: Tuesday -- No. 4 Sanford Seminole vs. No. 5 Spruce Creek, 7 p.m. Wednesday -- No. 7 Longwood Lyman vs. No. 2 DeLand, 6 p.m.; No. 3 Lake Brantley vs. No. 6 Lake Mary, 7:30 p.m. Friday -- Sanford Seminole/Spruce Creek winner vs. No. 1 Oviedo Hagerty, 6 p.m. Longwood Lyman/DeLand winner vs. Lake Brantley/Lake Mary winner 7:30 p.m. Saturday -- Championship, 7 p.m.
Outlook: Top-seeded Hagerty is 21-4 overall and 11-1 in the district. But DeLand enters on a four-game winning streak and the last time the Bulldogs met Hagerty they kept it close before losing 66-62.
Class 7A, District 3
When: Tuesday, Friday
Matchups: Tuesday -- No. 3 University at No. 2 Melbourne Viera, 7 p.m. Friday -- University/Melbourne Viera winner at No. 1 New Smyrna Beach, 7 p.m.
Outlook : NSB is the cream of the crop here. Led by Desmond Mitchell (17 points, 3.9 assists, 3.8 steals per game) the 'Cudas are 20-4 and 4-0 in the district.
Class 6A, District 8
When: Wednesday, Friday, Saturday
Where: Seabreeze
Matchups: Wednesday -- No. 4 Pine Ridge vs. No. 5 Seabreeze, 6 p.m.; Friday -- No. 2 Daytona Beach Mainland vs. No. 3 Deltona, 6 p.m.. No. 1 Edgewater vs. Pine Ridge/Seabreeze winner, 7:30 p.m. Saturday -- Championship, 7 p.m.
Outlook : Top-seeded Edgewater is 20-4 overall and 8-0 in district play. Mainland is led by sophomore Craig Wilmore, who has averaged a double-double for much of the season.
Class 5A, District 4
When: Tuesday, Friday
Where: St. Augustine Pedro Menendez High School
Matchups: Tuesday -- No. 2 Ponte Vedra vs. No. 3 Matanzas, 6 p.m.; No. 1 St. Augustine Menendez vs. No. 4 Ponte Vedra Nease, 7:30 p.m. Friday -- Championship, 7 p.m.
Outlook Top-seeded St. Augustine Menendez enters at 13-10 overall, 5-2 in district. Matanzas is led by Ivan Tsabak (14.2 points and 7.6 rebounds per game).
Class 3A, District 4
When: Tuesday, Friday
Where: Father Lopez
Matchups: Tuesday -- No. 3 Warner Christian vs. No. 2 Master's Academy, 5:30 p.m. No. 4 Lake Mary Prep vs. No. 1 Father Lopez, 7 p.m. Friday -- Championship, 7 p.m.
Outlook: Top-seeded Father Lopez will be tough to beat. The Green Waves feature three players – Cameron Breehl (18.4), A.J. Ford (14.6) and Malik Maitland (12.5) – who average double-digit points per game.
Class 2A, District 3
When: Tuesday, Friday
Where: Winter Park Geneva School
Matchups: Tuesday -- No. 1 Calvary Christian vs. No. 4 Halifax Academy, 5 p.m.; No. 2 Winter Park Geneva School vs. No. 3 Trinity Christian, 7 p.m. Friday -- Championship, 7 p.m.
Outlook: Top-seeded Calvary went 17-7 overall, 6-1 in district. The Lions are led by Zach Camporese (21.7 point per game). Winter Park Geneva finished the season 14-10 overall, 5-2 in district.


text:
Justin Bieber Defends Wearing Overalls to Meet Prime Minister
Justin Bieber defends his choice to wear overalls to meet Canadian Prime Minister Stephen Harper on his Instagram.
The 18-year-old singer defended himself after reading an article written by The Daily Mail's Hayley Peterson, who called him a "white trash prince."
PHOTOS: Check out the latest pics of Justin Bieber
Justin wrote, "The pic of me and the Prime Minister was taken in a room in the arena where i was performing at that day. I walked straight from my meet and greet to him, if you "Hayley" expect me to have a change of clothes let a loan [sic] a suit at that specific time that's crazy, It wasn't like it was like I was going into his environment we were at a hockey arena. Wow am i ever white trash hayley peterson lol."
The day before, Justin was spotted in Toronto, where he was rehearsing to perform at the half time show for the Grey Cup.


text:
2018 Lexus IS 300
Exterior Color: Most Colors
Dealer Location: Studio City, CA
Dealer Location: Westlake Village, CA
Dealer Location: South Pasadena, CA
Car Lease Transfer Leasing transfer services for 2017 Lexus IS 300 are available and the leasing company of record must be involved in the lease transfer process.
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text:
WASHINGTON, April 20 (UPI) -- Some Democrats in the U.S. Congress are criticizing the Obama administration for dealing with healthcare ahead of the nation's economic problems.
Rep. Brad Miller of North Carolina told The Hill the administration wasted both time and political capital on healthcare reform.
The constitutionality of the law's mandate that every American purchase health insurance is before the U.S. Supreme Court.
"I think we would all have been better off -- Democrats in Congress politically, and the nation would have been better off -- if we had dealt first with the financial system and other related economic issues and them come back to healthcare," Miller said.
He said economic problems would continue to plague President Barack Obama's 2012 re-election chances.
Rep. Dennis Cardoza of California also criticized his party's handling of the healthcare issue and said he repeatedly called on leaders to figure out how they were going to pay for the measure.
Most of the second-guessing on the healthcare issue has come from Democrats retiring from Congress, The Hill said.
Rep. Barney Frank of Massachusetts told an interviewer Democrats "paid a terrible price for healthcare."
The party lost 63 seats and control of the House of Representatives in 2010, a little more than six months after Obama signed the bill into law. Republicans picked up six seats in the Senate.


text:
NEW YORK (AP) — He started from the bottom, but now he's on top at the BET Awards: Drake has 12 nominations.
BET announced the nominees Tuesday. Rappers Kendrick Lamar and 2 Chainz are up for 8 awards each.
Drake is nominated three times for the top prize, video of the year. His hit, "Started from the Bottom," will compete with his collaborations with 2 Chainz ("No Lie") and A$AP Rocky ("Problems"). The top award has 10 nominees, including Justin Timberlake's "Suit & Tie," Kanye West's "Mercy," ''Adorn" by Miguel and Macklemore & Ryan Lewis' "Thrift Shop."
Chris Brown and R. Kelly will perform at the awards show, to air live June 30 from the Nokia Theater L.A. Live.
Chris Tucker will host the BET Awards.


text:
Coming through the death of a parent
The death of a parent is one of the key milestones of life, one of those points of no return after which life can never be quite the same again. Whether the death was expected or unexpected, welcome or unwelcome, now they are gone. And you cannot escape the physical, emotional and practical demands of your new situation. Many people are shocked by how overwhelming the experience of the death of a parent can be.
The 'end of the world' feeling that surrounds the death of a parent
The experience we all share, of course, is that up until now our parent or parents have 'always been there' - a fundamental fact of our lives. Even though we intellectually know that everyone will die one day, this knowledge is not enough to shake the inner conviction of permanence we have built from our experience. So when a parent dies, it can feel as if the very foundation of your world has crumbled.
So fundamental is the place of our parents in our understanding of our lives that even people who have not seen their parents for many years, or who have only a distant relationship with them (or none at all), can feel as if their world has fallen apart. This can seem quite inexplicable to them, and they may be shocked and frightened by it.
Coping with the death of a parent can be a demanding process
Whatever the nature of your relationship with your parent while they were alive, coping with their death and your feelings, dealing with the process of grieving, adjusting to life without them practically and emotionally can all make enormous demands on you. You need to gather all your resources to help yourself come through this time.
There is no right or wrong way to grieve for your parent
Remember that, even if the death of your parent was expected, you will still be in a state of shock. You may feel dissociated from what is happening around you, or as if you are operating on automatic pilot. You may be overwhelmed by emotions, or feel quite blank. All such reactions are normal - there is no 'right' way to feel in such circumstances. So whatever you feel, you can just accept that that is how you feel.
Grief is not something that 'happens' to you
The process of grieving uses a great deal of energy - much more than people would credit who have not experienced it. It can be very exhausting - as can coping with the grief of others around you who may also have been affected by this death. But even though it feels as if grief is a tidal wave sweeping you helplessly away and there is nothing you can do about it, there actually is a way to ride this wave.
You see, grieving is something that you do. That is, it is a behavior, and like all behaviors, it can be done more or less skillfully. In grieving, you gradually let go of the life that included the living presence of that parent, and adjust to and appropriate the life where their presence has become a memory. And there are a number of ways you can ease yourself through this necessary and inescapable task.
Hypnosis can help you grieve well for the death of your parent
Death of a parent is an audio hypnosis session which can help you with the psychological task of accepting the passing of your parent and preparing for the life you must now live. In this session, you will learn how to gain some control over the emotions associated with grief without having to suppress or deny them. You will be able to enjoy times of deep rest which will help you 'recharge' before you go on again.
Listening to Death of a parent will help you to build a new perspective on what your relationship with your parent can mean to you in the future. You will find that it is possible, however sad and bereaved you now feel, to begin to look forward again to being able to enjoy the good things that life has to offer you, while fully honoring the memory of your parent in ways that are appropriate and satisfying to you.
Download Death of a parent and give yourself the chance to grieve well.
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text:
Illinois trying to limit spread of deer disease
ROCKFORD, Ill. (AP) — Illinois wildlife officials want to persuade landowners in some northern Illinois counties to let them shoot deer to control the spread of chronic wasting disease.
The Rockford Register Star reports (http://bit.ly/1a35Czy ) that the Illinois Department of Natural Resources will be approaching Rock River Valley property owners as part of an effort to limit the spread of the illness, which affects the nervous system of members of the deer family and is always fatal.
Experts say using sharpshooters to cull the herd helps limit the spread of the disease.
State figures show there were 36 cases of chronic wasting disease reported in the state in the 2013 fiscal year.
The first case was reported in Illinois in 2002 and state wildlife officials have since sampled tens of thousands of deer. Since then, 408 cases of the illness have been confirmed, according to state statistics. About two-thirds of those cases were found in Winnebago and Boone counties.
But some hunters are skeptical of the plan.
South Beloit resident Robert Miller says the state should instead extend the deer hunting season.
"The state of Illinois is broken and then they are still spending thousands of dollars" for state employees to come hunt in the region, he said.
But Doug Dufford, the DNR's wildlife disease and invasive species manager, said cutting down the number of deer in the region is essential for maintaining the health of the herd.
"It's a program that to be honest nobody wants to do. It's very expensive, and it's a lot of work," Dufford said. "It's not particularly pleasant, but it's necessary if we're going to ensure that there's a deer herd in Illinois 40 years from now."
Deer that contract chronic wasting disease become emaciated and uncoordinated and eventually lose weight and die. But some infected deer may not show signs of the illness for 18 months after they've been infected, according to the Illinois Department of Natural Resources.
Information from: Rockford Register Star, http://www.rrstar.com


text:
oojacoboo needed a new logo design and created a contest on 99designs.
A winner was selected from 686 designs submitted by 180 freelance designers.
RentPost is a Software as a Service startup company focusing on managing rental properties and rental collection for tenants.
Our target audience is primarily businesses and property owners/managers, as well as people who pay rent.
We want to place emphasis on "POST" being a central location, hub, station, as in a Post, like a physical military post, or fence post, or any kind of post, representing one place; THE PLACE!
Below is a list of logos that should be some inspiration and the style type we like. THINK CLEVER, CREATIVE, using shapes and letters, but don't be scared to add a little fun and enthusiasm with shapes/design/illustrations and colors.
Find out how a design contest works or learn more about our logo design services.


text:
This product is currently sold out.
You can obtain status and/or reserve this item by contacting us. We can also be reached by calling toll free 1-866-326-9377 (Dialing from outside the US +01 314 772 3566) between 10AM and 6PM CST (-6 GMT).
2(x)IST's Tartan collection screams preppy and festive. The Tartan No-Show Trunks are made of soft cotton that stretches to your body. With a contour pouch and contour stitching, these basic trunks encompass comfort and style. The plaid logo waistband adds a loud print that's right on key for the holidays.
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|Extra Large
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text:
Selected SEMI ISS US 2012 Presentations
All documents are PDF files of presentations provided at ISS 2012 in Half Moon Bay in January 2012.
Documents are available for SEMI Members only.
If you or your company is a SEMI member, but you do not have a profile create one now. Be sure to use your company e-mail when you create or update your profile. SEMI recognizes your membership status using your company email address.
|Technology Delivers
|William M. Holt
|Innovation-Defining The Future of Semiconductors
|Bernie Meyerson
|Accelerating Change
|Mike Splinter
|Profitless Prosperity Revisited: Where Do We Go from Here?
|Steve Newberry
|The Health of the Global Electronic Materials Supply Chain
|Mark Thirsk
|450mm: Making the leap without slipping on an icy semiconductor cycle
|G. Dan Hutcheson
|Materials Development Enabling Advanced Products
|Tim Hendry
|Shocks and Correlations to the Semiconductor Market
|Bill McClean


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James Ensor's Profound Paintings on View at Musée d'Orsay
James Ensor, "La raie", 1892. Huile sur toile, 80 x 100 cm. Bruxelles, Musées royaux des Beaux Arts de Belgique © ADAGP, Paris 2009.
When presented at the Musées Royaux des Beaux-Arts de Belgique in Brussels and at the Koninklijk Museum voor Schone Kunsten in Antwerp, the work of James Ensor (1860-1949) is that of a Belgian painter who is both innovative and tortured. Presented at the
Musée dOrsay
, his original and profound paintings are those of a 19th-century artist situated between Naturalism and Modernity. Presented at the MoMA, his work fits brilliantly and naturally into the great avant-garde movements that are the forte of this museum. Furthermore, it was this powerful originality that Alfred Barr stressed in 1940, when he acclaimed the "Tribulations of St. Anthony", declaring that Ensor was, at the time he produced this painting in 1887, the boldest living artist.
Sixty years after his death, James Ensors legacy is divided between his Belgian roots, his life in Ostend in fact, and his international reputation. It is divided, too, between the solid Naturalism of his early work and the masked imaginary creatures, skeletalised, virulent and caustic, that stride through the main part of his work with colourful, grimacing steps.
Almost one hundred and fifty years after his birth, Ensor remains a strange, unclassifiable painter, and the title painter of masks, attributed to him by his compatriot Émile Verhaeren does not fully define his unclassifiable, prolific, polymorphic work.
The MoMA and the Musée dOrsay have therefore decided to revisit Ensor, and, one hundred and ten years after the failure of his first exhibition in Paris, to question once again his impenetrable masks and his menacing skeletons; to place him in the 20th-century where he largely belongs, having witnessed the dawning of Expressionism, Cubism, Futurism, Dada, Surrealism, etc. and, in his own words, having anticipated all the modern movements, and also to place him at the heart of the 19th-century where he was certainly one of its unruly children, resolutely claiming a definitive place between Manet and Van Gogh.
With 90 paintings, drawings and engravings, the James Ensor exhibition, in four parts, enables us to take a new look at this painter who remains an enigma today, coming between Manet, Van Gogh and all the modernist movements.
A kind of modernity
The exhibition opens with Ensors early work. After training at the Académie de Beaux-Arts in Brussels, he rejected its teachings, and chose to return to work in his home town of Ostend. There, he explored his surroundings, exterior and interior, in many paintings and drawings. He produced landscapes, still lifes and portraits, as well as genre scenes featuring his sister, mother and aunt.
The critics, like Émile Verhaeren who produced the first monograph on Ensor in 1898, tried to draw a parallel with French Impressionism, which the artist rejected vigorously, arguing that his experiments into light were more profound and more subtle. I have been mistakenly placed with the Impressionists, those plein air hacks who are so fond of pale colors. I was the first to understand the distortion that light inflicts upon line. Nobody else attached any importance to it ; painters just relied on what they saw. The Impressionist movement left me cold. Édouard Manet was no better than the painters of the old school, he declared in 1899. The "Oyster Eater", the high point of his early Modern and Naturalist work, was rejected at the 1882 Salon in Antwerp. Ensor then committed himself to the liberalization of artistic exhibitions, and fought to become the leader of an artistic school. He was particularly involved in creating the group known as Les XX. In 1883, masks started to appear in his work, and Ensor went back to part of his work from the early 1880s to populate it with these masks and skeletons that were now part of his universe.
Light has ennobled me
Brought up on the shores of the North Sea, Ensor was passionate about the effects of light. Unlike Monet in particular, invited by Les XX to exhibit in 1886, and who saw it as a multitude of fleeting effects, Ensor perceived light in its fundamental unity.
This unity led him to a mystical vision that he expressed in 1885-86 in his series "The Haloes of Christ" or the "Sensitivities of Light". Presented at the Salon des XX in 1887, these enormous drawings did not receive the acclaim that Ensor had hoped. Everyone acclaimed Seurats "A Sunday Afternoon on the Island of the Grande Jatte", also exhibited at the Salon des XX, but they could not understand Ensors submission.
Hurt, disappointed and despairing, (he confided: The critics violent attacks have been destroying my convictions for some time, and I have suffered much through doubt. I have a very impressionable and sensitive nature), the artist took refuge behind his masks and his skeletons. The enormous "Christs Entry into Brussels" in 1889 (Los Angeles, The Paul Getty Museum) was his response to Seurats painting and to the detractors of his work. His new style, with its vivid colors, masks, banners and parade of strange characters, introduced a new phase of his work. He explained this development thus: It should be noted that there has been a development in my style here. In order to make the tones rich and varied I had always blended the colours. Unfortunately, this mixing process altered certain paints, and some of the paintings have become darker. So I have now changed my approach, and have applied pure colours. I naturally looked to use striking effects and especially masks, where vivid tones predominate. I also liked these masks because they offended the public who had received me so badly. (1898)
Strangeness reigns everywhere
Carnival and masks were part of Ensors family tradition. In 1887, at a time of great personal crisis over the lack of understanding he felt was directed at him, Ensors father and grandmother, to whom he was very close, both died. From then on, Death accompanied the masks. They form a parade or perform incomprehensible pantomimes. At the same time, Ensor took his revenge for the attacks directed at him, in a series of works whose vehemence and lack of constraint were unequalled in these final years of the century.
The painter of 112 self-portraits
The other area where Ensor gave vent to his terrible feeling of persecution was the selfportrait. He painted images of himself throughout his career. In his early paintings, he appeared young, dashing, full of hope and spirit, at times sad but still splendid. Soon, however, he vented his rancour by subjecting his image to a number of metamorphoses. He was a herring, a madman, a skeleton, etc. He identified himself with Christ and then with a humble pickled herring. He caricatured himself, made himself look ridiculous. He was both puppet master and puppet, in comedies and tragedies into which he would invite his detractors in order to settle old scores quite cruelly. From 1892 onwards, he began not only to paint himself, but also to depict himself among his paintings. Ensor became a character preparing his legend and his place in the history of painting over a very long period of time.
A selection of objects
Throughout the exhibition, objects, masks, seashells, a mermaid, all coming from the Ensor family house and souvenir shop, complete this fantastic and curious world, and show the close ties the artist had with his strange surroundings, described by Verhaeren in 1908. He described the studio, invaded by disparate objects: masks, scraps of fabric, withered branches, shells, cups, pots, threadbare carpets, books lying all over the floor, prints piled up on chairs, empty picture frames leaning against the furniture and the inevitable skull looking at it all through the two empty holes of its absent eyes. And the shop with its large windows stuffed with trinkets that were of no interest at all. It was there, amid the seashells and mother of pearl, the vases from China and lacquer work from Japan, the versicolored feathers and the gaudy screens, it was there that the painters visual imagination composed its most unusual and most wide-ranging symphonies of color. With a touch that was both delicate and strong, subtle and raw, sober and dazzling, he could make a vibrant image from some humble eastern trinket made commonplace by fashion! And the well-shaped shell adorning the painted marble mantelpiece of some gloomy bourgeois household, would, through the magic and the alchemy of the artist, become a miracle of triumphant colour that would light up the most beautiful galleries of modern museums today. Ensor enjoyed himself amongst these thousands of exotic trifles, amongst these glistening, glassy spoils of the sea.
Musée d' Orsay
James Ensor
Émile Verhaeren
Today's News
October 22, 2009
FIAC to Offer 25 Museum-Quality Artworks with Multimillion-Dollar Price Tags
Rocco Landesman Announces "Art Works" Tour, First Stop: Illinois
Rubens Challenges the Old Masters at the Alte Pinakothek
Peter Greenaway's New Film Offers Fierce Criticism of Today's Visual Illiteracy
Important and Iconic Works from the Masters of Asian Art at Christie's
Guggenheim in Bilbao Celebrates Frank Lloyd Wright with Exhibition
Museum Collection's Storage System Revolutionized by Collaboration
Bust of Roman Emperor Caracalla for Sale at Bonhams
Wayne Hemingway Invites an Army of Local DJs to Take Over Tate Liverpool
Guggenheim and Google Announce Winners of Global Design Competition
Christie's to Present an Important Auction of Orientalist Masterpieces in London
Major Exhibition to Paint a New Picture of Queen Victoria
MFAH Secures First European Presentation of Adolpho Leirner Collection
James Ensor's Profound Paintings on View at Musée d'Orsay
Museum für Moderne Kunst Frankfurt Shows Photographs by Barbara Klemm
First Solo Exhibition in Paris for Tris Vonna-Michell at Jeu de Paume
British Museum Opens Revolution on Paper: Mexican Prints 1910-1960
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Archaeologists Unveil Ancient Auditorium in Rome
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Sotheby's breaks auction record for any bottle of wine twice in one sale
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Prime Minister Mark Rutte gives a history lesson in the Rijksmuseum
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text:
BIOL368/F11:DNA Microarrays
From OpenWetWare
Revision as of 16:02, 2 November 2011 by Kam D. Dahlquist (talk | contribs) (→Preparation for Next Week's Journal Club: fixed linnk)
Note that this site is under construction.
- 1 Background
- 2 Groups
- 3 Week 10
- 4 Week 11
- 5 Week 12
- 6 Week 13
- 7 Week 14
- Brown, P.O. & Botstein, D. (1999) Exploring the new world of the genome with DNA microarrays Nature Genetics 21: 33-37.
- Campbell, A.M. and Heyer, L.J. (2003), "Chapter 4: Basic Research with DNA Microarrays", in Discovering Genomics, Proteomics, and Bioinformatics, Cold Spring Harbor Laboratory Press, pp. 107-124. (Available on MyLMUConnect)
- DeRisi, J.L., Iyer, V.R., and Brown, P.O. (1997) Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale. Science 278: 680-686.
- Alex, Bobby, Zeb - Staphylococcus aureus MRSA252
- Chris, Nicki - Mycobacterium smegmatis
- Isaiah, Sam
Week 10
Introduction to DNA Microarrays
Answer the following Discovery Questions from Campbell & Heyer Chapter 4
- Number 5 from p. 110: Choose two genes from Figure 4.6 (PDF of figures on MyLMUConnect) and draw a graph to represent the change in transcription over time.
- Number 6b. from p. 110: Look at Figure 4.7, which depicts the loss of oxygen over time and the transcriptional response of three genes. These data are the ratios of transcription for genes X, Y, and Z during the depletion of oxygen. Using the color scale from Figure 4.6, determine the color for each ratio in Figure 4.7b.
- Number 7 from p. 110: Were any of the genes in Figure 4.7b transcribed similarly?
- Number 9 from p. 118: Why would most spots be yellow at the first time point?
- Number 10 p. 118 Go to http://www.yeastgenome.org and search for the gene TEF4; you will see it is involved in translation. Look at the time point labeled OD 3.7 in Figure 4.12, and find the TEF4 spot. Over the course of this experiment, was TEF4 induced or repressed? Hypothesize why TEF4's gene regulation was part of the cell's response to a reduction in available glucose (i.e., the only available food).
- Number 11 from p. 120: Why would TCA cycle genes be induced if the glucose supply is running out?
- Number 12 from p. 120: What mechanism could the genome use to ensure genes for enzymes in a common pathway are induced or repressed simultaneously?
- Number 13 from p. 121: Given rule one on page 109, what color would you see on a DNA chip when cells had their repressor gene TUP1 deleted?
- Number 14 from p. 121: What color spots would you expect to see on the chip when the transcription factor Yap1p is overexpressed?
- Number 15 from p. 121: Could the loss of a repressor or the overexpression of a transcription factor result in the repression of a particular gene?
- Number 16 from p. 121: What types of control spots would you like to see in this type of experiment? How could you verify that you had truly deleted or overexpressed a particular gene?
Finding a Journal Club Article/Microarray Dataset
- Next week you will begin the DNA Microarray Project by preparing for your next Journal Club presentation that will take place in Week 12. You will work in groups of 2 or 3 on this project. Groups are:
- Chris, Nicki - Mycobacterium smegmatis
- Isaiah, Sam
- Alex, Bobby, Zeb - Staphylococcus aureus MRSA25
- You may choose to work ahead towards this presentation by finding your Journal Club article and corresponding microarray dataset with which you will perform your project. Your task is to find a published microarray dataset that measures gene expression from one of the following species:
- Saccharomyces cerevisiae (yeast)
- Escherichia coli K12
- Helicobacter pylori
- Mycobacterium smegmatis
- Mycobacterium tuberculosis
- Plasmodium falciparum
- Pseudomonas aerugenosa
- Salmonella typhimurium
- Staphylococcus aureus MRSA252
- Vibrio cholerae
- Microarray data is not centrally located on the web. Some major sources are:
- EBI ArrayExpress
- Stanford Microarray Database
- PUMAdb (Princeton Microarray Database)
- In addition, microarray data can sometimes be found as supplementary information with a journal article or on an investigator's own web site.
- All journal club articles/microarray datasets are subject to approval by the instructor.
Week 11
Find your journal club article and microarray dataset and get approval from the instructor if you have not already done so.
Preparation for Next Week's Journal Club
In preparation for the Journal Club, each individual will do the following assignment on their individual Week 11 Journal page.
- Make a list of at least 10 biological terms for which you did not know the definitions when you first read the article. Define each of the terms. You can use the glossary in any molecular biology, cell biology, or genetics text book as a source for definitions, or you can use one of many available online biological dictionaries. List the citation(s) for the dictionary(s) you use; a proper citation of a web site includes the URL and the date accessed.
- Write an outline of the article. The length should be the equivalent of 2 pages of standard 8 1/2 by 11 inch paper. Your outline can be in any form you choose, but you should utilize the wiki syntax of headers and either numbered or bulleted lists to create it. The text of the outline does not have to be complete sentences, but it should answer the questions listed below and have enough information so that others can follow it. However, your outline should be in YOUR OWN WORDS, not copied straight from the article.
- What is the main result presented in this paper? (Hint: look at the last sentence of the introduction and restate it in plain English.)
- What is the importance or significance of this work?
- What were the limitations in previous studies that led them to perform this work?
- What were the methods used in the study?
- What samples did they collect and use for the microarray experiment?
- How many microarray chips did they hybridize in the experiment?
- Which samples were paired to hybridize on the chip?
- Which was labeled red (Cy5)? Which was labeled green (Cy3)?
- How many replicates did they perform of each type?
- Biological replicates are made from entirely different biological samples.
- Technical replicates are made when one biological sample is split at a particular stage in the procedure and then carried through to the end of the procedure.
- What do they say about how they performed each of the steps listed in the Overview of Microarray Data Analysis section below?
- Briefly state the result shown in each of the figures and tables.
- How do the results of this study compare to the results of previous studies (See Discussion).
- Upload your completed PowerPoint slides to your journal page by the Week 11 journal deadline (you may make changes before your presentation Tuesday morning, but I will be evaluating the presenttion you upload.)
Week 12
Overview of DNA Microarray Analysis
This is a list of steps required to analyze DNA microarray data.
- Quantitate the fluorescence signal in each spot in the microarray image.
- Typically performed by the scanner software, although third party software packages do exist.
- The image of the microarray slide and this quantitation are considered the "raw-est" form of the data.
- Ideally, this type of raw data would be made publicly available upon publication.
- In practice, the image data is usually not made available because the raw image file of one slide could be up to 100 MB in size.
- Also, some journals do not require data deposition as a requirement for publication, so often published data are not actually available anywhere for download.
- Microarray data is not centrally located on the web. Some major sources are:
- EBI ArrayExpress
- Stanford Microarray Database
- PUMAdb (Princeton Microarray Database)
- In addition, microarray data can sometimes be found as supplementary information with a journal article or on an investigator's own web site.
- Calculate the ratio of red/green fluorescence
- Log(base 2) transform the ratios
- Normalize the log ratios on each microarray slide
- Normalize the log ratios for a set of slides in an experiment
- Perform statistical analysis on the log ratios
- Compare individual genes with known data
- Look for patterns (expression profiles) in the data (many programs are available to do this)
- Perform Gene Ontology term enrichment analysis (we will use MAPPFinder for this)
- Map onto biological pathways (we will use GenMAPP for this)
Get Acquainted with Your Microarray Dataset
- Find the web site or database where your paper's microarray data are available.
- Download your dataset from this wiki and open it in Excel.
- Match the columns of data with your description of the experimental design from your outline.
- When you have completed this (in class), your group will meet with Dr. Dahlquist to get a customized protocol to follow for analyzing your data.
Week 13
- Project work session
- GenMAPP and MAPPFinder Protocols
- For the groups working with Arabidopsis thaliana, Staphylococcus aureus, and Vibrio cholerae, you will need to download the GenMAPP Gene Database for those species from the XMLPipeDB SourceForge site.
Week 14
- Final project presentations in class.
- Course evaluations


text:
AIR FORCE ACADEMY Wes Cobb scored twice on short runs, and Cody Getz rushed for 125 yards as Air Force beat Hawaii 21-7 on Friday night to become bowl eligible.
The Falcons (6-5, 5-2 Mountain West) are headed to a postseason game for the sixth consecutive season under coach Troy Calhoun. The team accepted a bid to the Armed Forces Bowl after the game.
Air Force didnt even attempt a pass all night, relying on a ground game thats ranked second in the country. The Falcons finished with 338 yards rushing.
Getz had another big night, eclipsing the 100-yard mark for the sixth time this season. The diminutive running back had a 5-yard touchdown run early in the third quarter to break a 7-7 tie with the Warriors.


text:
Leeds Grand Theatre
Families information
- Are booster seats available?
No – but you are welcome to bring your own
- Are there baby changing facilities?
Yes – at least one available in the stalls and one in the dress circle
- Is there an area for people to park their buggies?
Yes – Front of house staff will be able to help at the venue
- Where is the nearest parking?
Parking is available at various nearby car parks, including Edward Street/Templar Street and the St John's and Merrion Centre shopping malls. A limited amount of on street parking is available near the theatre is free after 6pm but this does tend to fill up very quickly.
- Any other information useful for people with young children coming to the theatre
There is lift access to most of the auditorium (excluding the Upper Balcony) from the foyer and a wheelchair access lift to the foyer from the Box Office. Please note that some areas of the auditorium do have steep stairs and may not be suitable for people with limited mobility. We recommend checking with the Box Office before purchasing a ticket if you have concerns.
The theatre has 13 spaces for wheelchair users across three seating levels; 6 in the Stalls, 4 in the Dress Circle and 3 in the Upper Circle. Accesible toilets are located in the Stalls and Dress Circle.
A £1.50 transaction fee will apply for internet and phone bookings. Postage charge £1 where applicable. Booking in person at the Box Office & Group bookings carry no additional charge.


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Hello everybody.
I recently got my proxy chaining apps running, and stuffed it with a few valid proxies. I tried it on several applications, like ftp, web, ssh, irc, nmap etc and it works fine. The target shows the last proxy server in the list of chains. My questions is:
How do i know that its acutally going through all the proxies in the list. It says its chaining through them all, but how can i be certain of that?
Better said, how can i trace it back each proxy at a time? Or would i have to view the logfies of each proxy server it goes through (time stamps)?
Any solution would be much appreciated.
Cheers everyone.


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WASHINGTON (AP) — Guest lineups for the Sunday TV news shows:
ABC's "This Week" — President George W. Bush and Laura Bush; Egypt's ambassador to the United States, Mohamed Tawfik.
NBC's "Meet the Press" — Egyptian reform leader Mohammed ElBaradei; Sen. Robert Menendez, D-N.J.; Rep. Raul Labrador, R-Idaho.
CBS' "Face the Nation" — Sen. John McCain, R-Ariz.; Reps. Michael McCaul, R-Texas, and Xavier Becerra, D-Calif.; Janet Murguia, president and CEO, National Council of La Raza; Dan Stein, president of the Federation for American Immigration Reform.
CNN's "State of the Union" — Gen. Martin Dempsey, chairman of the Joint Chiefs of Staff; Rep. Mike Rogers, R-Mich.
"Fox News Sunday" — Sens. Bob Corker, R-Tenn., and Jack Reed, D-R.I.; Gov. Rick Perry, R-Texas.


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Tinker's toys
Looking for a day trip that offers history, a love story with a boy-gets-girl ending, and a self-made man who makes good — along with some Lincoln lore? The Tinker Swiss Cottage has it all: the story of John Manny, who invented the Manny Reaper, was sued for patent infringement, died young, and left a beautiful, wealthy widow who married a company employee, Robert Tinker.
The story begins when Cyrus McCormick invented his famous reaper in 1831 and became the undisputed "Reaper King" until a little competition heated up. An upstart manufacturer, the Manny Reaper Co. of Rockford, became a thorn in McCormick's side when, at the Paris Exposition of 1855, the Manny Reaper beat the McCormick Reaper. Cyrus McCormick filed suit against John H. Manny for patent infringement.
Manny set out to prove that the reaper was his own invention. Learning that the trial was to be held in Springfield, he decided that it would benefit him to hire a local lawyer. The firm turned to Abraham Lincoln, who at the time was experiencing financial and political setbacks and was more than happy to be part of a high-profile trial.
With a $500 advance, Lincoln worked on his brief for months. Unfamiliar with patent law, Lincoln traveled to Rockford to learn more about the Manny Reaper. But the trial was moved to Cincinnati, and attorneys Edwin Stanton, George Harding, and P.H. Watson no longer needed or wanted Lincoln's services. Edwin Stanton, who later served as secretary of war in Lincoln's cabinet, said that he didn't want to associate with "such a damned, gawky, long-armed ape as that."
Lincoln arrived in Cincinnati in his best suit, but Stanton's rudeness caught Honest Abe off guard. Stanton described his future president as "a long, lank creature from Illinois, wearing a dirty linen duster for a coat and the back of which perspiration had splotched wide stains that resembled a map of the continent."
Lincoln handed the brief he'd prepared for the case over to the unimpressed lawyers and returned to Illinois. The brief was never used, but Manny's lawyers prevailed. Although Manny won the suit, victory was short-lived: In 1856, 30-year-old John Manny died of tuberculosis. His widow, Mary, took over the operation of the Manny Reaper Co. and other Rockford properties. At the time of her husband's death, Mary Manny lived in the Manny Mansion, an Italianate brick structure that was eventually torn down in 1900 because it was so close to the railroad that it was literally being shaken apart.
The year Manny died, 19-year-old Robert Tinker arrived in Rockford at the urging of William Knowlton, Mary Manny's business manager. Two years later, Knowlton and Tinker became business partners. Tinker's relationship with Mary, who was eight years older, would prove even closer: In 1870, the two married and embarked on a honeymoon to Hawaii, where Tinker had been born.
Tinker was a talented artist, and, during a nine-month European tour in 1862, he kept a detailed log of travels, including sketches of the places and farm machinery he saw. The trip provided the inspiration for Tinker's greatest legacy. In 1865, Tinker began work on an elaborate 20-room Swiss cottage, a project that continued into the 1880s with the addition of a conservatory. The cottage was connected to the grounds of the Manny Mansion by a suspension bridge over nearby Kent Creek. A replacement for the original bridge, which was removed in 1976, is near completion, and an ice-cream social to formally dedicate the new structure is planned for June 12.
The Tinker Swiss Cottage has several characteristics of the Romantic style, including a front gabled roof, deep-bracketed eaves, and a second-story balcony with flat balustrades and trim decorated with cut-out patterns.
The cottage, which looks a bit like the dwarves' residence in Walt Disney's Snow White and the Seven Dwarfs, is filled with the Tinkers' furnishings, artwork, and diaries.
The Tinkers were a social force in Rockford. In addition to their business enterprises, they were active in the community. Robert Tinker served as mayor of Rockford for one year. Although Mary Dorr Manny Tinker never had children, she reared her nieces, Marcia and Jessie, after her sister died. In 1904, after Mary and Marcia were dead, Robert Tinker married Jessie; four years later they adopted a baby, and Robert Tinker became a father at the age of 72.
Robert Tinker died on Dec. 31, 1924 — his 88th birthday. Two years after his death, Jessie Tinker sold the cottage to the Rockford Park District but lived in it until her death, in 1942. The cottage has since been restored to its former beauty.
Tours of the cottage, which is located at 411 Kent St. in Rockford, are provided at 1, 2, and 3 p.m. Tuesday-Sunday. For more information, call 815-965-2424 or visit www.tinkercottage.com.
While visiting Rockford, you may also want to tour the Burpee Museum of Natural History, where "Jane" the dinosaur will soon go on display; the Midway Village and Museum Center; and the Magic Waters water park. For garden lovers, there is the beautiful Anderson Japanese Garden, along with the Klehm Arboretum and Botanic Garden. For those looking for a little cultural history, a tour of the Erlander Home Museum offers insight into Rockford's Swedish-American Heritage. For Rockford tourism information, check out the Rockford Area Convention & Visitors Bureau Web site, www.gorockford.com, or call 800-521-0849.
Directions: north on I-55, the north on I-39; approximately 3 hours.


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Animal Abuse & Violence
Research finds a clear and compelling link between animal abuse and other violent acts. Animal abuse does not only hurt animals; it affects our entire community.
Animal abuse also has a strong connection to domestic violence. Victim's dogs and cats are often used by abusers as pawns to manipulate and control them. In an abusive home, a companion animal may serve as a lone confidant for an abused woman or child and, by abusing the animal, an abuser is taking advantage of the victim's concern for his or her animal. Abusers may threaten animals to keep children and partners from reporting abuse or to keep them from leaving. Often acts of abuse are perpetrated in the presence of adult and child victims. By hurting the animals, an abuser is sending the message that a human victim could be next.
The Effect Upon Children
Children who witness such abuse are three times more likely to abuse animals and, later in life, to play a role in an abusive relationship.
Family violence perpetuates the detrimental cycle of violence. The Wisconsin Humane Society has created several programs to promote empathy in children and to prevent violence in the Milwaukee community.
Whenever an animal is abused, a chain reaction begins in our community. Not only does an innocent animal get injured, but the person who commits the offense often falls into a cycle that could ultimately result in violence against other people. The evidence of a link between cruelty to animals and violence toward humans is compelling. In the vast majority of cases, cruelty to animals is just one aspect of a social environment marked by violence. In fact, people who abuse animals are five times more likely to commit violent crime.
Animal abuse, like many other forms of abuse, is about power and control over a helpless victim. It is intolerable. By taking action against animal cruelty, we not only prevent animal suffering, but also uncover and perhaps prevent additional crimes. Understand the link and take animal abuse seriously. Hurting an animal hurts us all.
Why legislation to include animals in restraining orders is important
Many victims are hesitant to leave a dangerous situation because they fear for their animal's safety.
Their fears are not unfounded. Abusers often retaliate when their victim leaves by torturing or killing their animals. Currently, an abused person can obtain temporary and permanent restraining orders issued by the court to keep abusers from having contact with them or with their children. However, their concern for their animal's wellbeing is not addressed, leaving some victims afraid to leave a situation that is unsafe for them and their children.
Recently, some states have changed their legislation to include protections for victims' animals, which gives people the opportunity to leave an abusive situation with peace of mind. Such legislation has passed in Maine, Vermont and New York and has been introduced in several other states.


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This next season is make or break time for the Miami Dolphins.
They will either prove that they are a team here to stay, or they will sink back into the failure of the Dolphins team three years ago when they only won 1 game out of 16.
When head coach Tony Sparano and other new staff took over two years ago they helped turned the Miami Dolphins organization around. They went from 1-15 to 11-5 in only one season. They went from the bottom of the league to one of the best records in the league.
Last season the Miami Dolphins were brought down to earth when they went 7-9. The season started off in a bad way with an 0-3 start, and was also capped off in a bad way when they lost the last three games of the season. The middle of the season was much better, as the Dolphins went 7-3.
Hopefully, this coming season will be a lot better. It better be, because it will determine a lot about the Miami Dolphins future.
If Miami is able to win and do well next year it will prove that they are a good team that is here to stay.
If they do horribly, then they will have to start all over again. The rebuilding process will have to start over again, and the last two years will have been wasted.
Two seasons ago the Dolphins were hot, and last year was a little bit of a cooling process. Now, let us all hope that Miami will heat up again so they can stay hot for years to come.
Dolphins fans were tired of seasons of failure, so when the 11-5 season came around it was a refreshing feeling. Now, lets hope Miami can keep winning because it is make or break time.
I hope to be able to wear a Super Bowl Champions hat and t-shirt with a Dolphins logo on it, and I want to be able to see the commercial after the Super Bowl that advertises a DVD paying tribute to the Super Bowl Champion Miami Dolphins.
You've all heard it before, and it would sound something like this:
"Dolphins fans, your team has just won the Super Bowl. Celebrate this historic win with..."
So Dolphans, we will see how this season turns out. Hope that it is a favorable outcome because that will tell us how the next few years will be at Sun Life Stadium in South Florida.
Thanks for reading and please check out my blog here: Dolphin Shout
Share |


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PSD Climate and Weather Data
PSD archives a wide range of data ranging from gridded climate datasets extending hundreds of years to real-time wind profiler data at a single location. The data or products derived from this data, organized by type, are available to scientists and the general public at the links below.
Type: Satellite
- Blended Sea Surface Temperature Products
- Available from web or ftp.
- Satellite-Derived Heat Fluxes and Near-Surface Specific Humidity and Air Temperature
- Sample Data


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Blackburn Voyager 2.0 LED Headlight and Mars Click Tail Light Combo
Item: 40-0392
Save $5.02 (17%) $24.97 MSRP $29.99
Save $5.02 (17%) $24.97 MSRP $29.99
Staying visible and safe on the road is easy with Blackburn's front/rear light set. Voyager 2.0 LED headlight projects 30 lumens of vivid light, so you can be easily spotted in low light or dark conditions. Mars Click tail light with dual red LEDs lets cars and pedestrians know exactly where you are. Fast, reliable and easy to use, this light set is a perfect choice for regular commuters.
- 3 LEDs cast 30 lumens of super-bright light
- Runtimes: 65 hours (Steady), 130 hours (Flashing)
- Easily mounts to any handlebar
- Includes 3 AAA batteries
Tail Light:
- 2 super-bright red LEDs provide 180° of visibility
- Runtimes: 70 hours (Steady), 140 hours (Flashing)
- Press the lens to turn it on
- Silicon straps mount to any seatpost -- no tools required
- Includes 2 CR2032 batteries


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Please me
Views: 1379 | Added: 7 years agoMore
Cassandra made a deal with the janitor at school. She told him to steal the answers to the big exam coming up and she would pay him 500 dollars. He got her the answers, but she only had 300 dollars. She made another deal to make up the rest of the money. She told him she would give him the best blow job he ever had. She did a great job sucking that cock and the janitor wanted more. He bent her over and munched on her ass while playing with her sweet pussy. She got her succulent pussy pounded and got a crea
Submitted by: realitykings


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what is the differance between eclipes and netbeans ?
1)Support for Maven is better in NetBeans. Because you can get GlassFish with Java EE package for NetBeans, it is easier to use than in Eclipses (as you have to configure GlassFish separately).
2)NetBeans comes with build-in GUI builder for Swing, but you need to use a separate plug-in in Eclipse.
3)NetBeans has a strong support when you are developing MVC based application in Java. Servlet/JSP development is fairly very simple compared to Eclipse, especially in the field of deployment and debugging.
4)NetBeans comes with in-built support for and SQL, MySQL and Oracle drivers plus it includes some others too. So this definitely makes things easy for beginners. However Eclipse has JDBC driver support ? but it takes some serious time to configure the connection.
5)Netbeans editor is missing several Eclipse features. Spell check being one prominent one. Quick complete (Ctrl-K, Ctrl-J) is an underused Netbeans feature. Snippets being another (though they have an auto-complete template which fills a different, but similar niche).
The general opinions within the Java community about these two IDE are fairly similar. For basic Java (Java SE) development, they both offer comparable features. But if you have a specific purpose, one IDE might be slightly better than the other. For example, there is a general consensus that for developing on OSGi platform, Eclipse is the better option, while NetBeans is better for Java EE development.


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My 4 year old Oniotchi died today and i dont know why. he was fully fed and had 3 happiness hearts when i went to lunch and when I got back an hour later he was dead! I cant figure out why. He went without full happiness hearts for long periods of time so culd this be what contributed to his early demise?
Why Oh Why
Started by Tel , Oct 28 2004 07:17 AM
Started28 Oct 2004
Last Post28 Oct 2004
Posted 28 October 2004 - 08:41 AM ( #2 )
Oh im sorry that happened to u. I dont exactly know but that might hav been why. Sorry i cant help anymore


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Sab B******s unite
why oh why, surely you can use facebook on normal phones, if you so wished
Social networking fanatics can now get their online fix when they're out and about, because 3 today began selling the INQ1 Facebook phone. INQ1_open 3's INQ1: for Facebook Although the INQ1 was announced quite a while back, 3 – the phone's exclusive UK carrier – has kept mum until now about exactly when punters will be …
why oh why, surely you can use facebook on normal phones, if you so wished
"Up to 3.6Mbps". And now in the real world my mobile "broadband" dongle gets 400kbps download and a whopping 25kbps upload on average. Only saving grace is I got 5Gb/month for £7.50 via Quidco instead of £15/month and it works in an unlocked 3G phone as well as in the dongle.
I see 3 have spawned another device in a desparate attempt to get someone to put their network to use, so first it was Skype and now facebook as I reckon that a lot of people return their dongles when they realise that the service is crap and that the mobile operators are lieing to them as in order to get the top speed you have to be the ONLY person on that particular cell, so its ADSL without wires, so its mobile somethingband then.
GSM still had plenty of life in it
@rob, agree with you totally mate
Indeed you can faceook on any phone, but the point of this is its running on the phone software and can bring all your contact over different mediums into the one inbox
and at 15 quid a month its competetivley priced
its getting good reviews elsewhere i'd love to know what El Reg thinks, as i might get one of these


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Study of CS-7017 in Colorectal Cancer Patients Who Have Achieved Disease Control Following First-Line Chemotherapy
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00986440
Recruitment Status : Completed
First Posted : September 30, 2009
Last Update Posted : April 14, 2015
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Colorectal Cancer
|Drug: CS-7017 Drug: Placebo
|Phase 2
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|86 participants
|Intervention Model:
|Parallel Assignment
|Triple (Participant, Care Provider, Investigator)
|Primary Purpose:
|Official Title:
|A Randomized, Double-Blind Placebo-Controlled Phase 2 Study of CS-7017 in Colorectal Cancer Patients Who Have Achieved Disease Control Following First-Line Chemotherapy
|Study Start Date :
|July 2009
|Actual Primary Completion Date :
|January 2013
|Actual Study Completion Date :
|January 2013
|Experimental: CS-7017
Drug: CS-7017
Placebo Comparator: Placebo
Placebo matching CS-7017
Drug: Placebo
- Compare PFS rate of participants treated with CS-7017 versus placebo. [ Time Frame: 18 weeks ]
- Compare overall PFS of participants treated with CS-7017 versus placebo. [ Time Frame: 18 weeks ]
- Compare overall survival of participants treated with CS-7017 versus placebo. [ Time Frame: 18 weeks ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients with histologically confirmed, metastatic CRC that have achieved confirmed maximal benefit of DC following treatment with standard first line chemotherapy of a 5-fluoropyrimidine plus either oxaliplatin or irinotecan. Patients should be entered onto this trial within 8 weeks of completing first line therapy;
- If CR was not achieved: measurable disease, i.e. at minimum one unidimensionally-measurable target lesion according to RECIST (Response Evaluation Criteria in Solid Tumors);
- Age >= 18 years and Eastern Cooperative Oncology Group (ECOG) performance status (PS) =< 2 at study entry;
- Resolution of any toxic effects of prior therapy (except alopecia) to NCI CTCAE, Version 3.0, grade =< 1;
Adequate organ and bone marrow function as evidenced by:
- Haemoglobin >= 10 g/dL (transfusion and/or growth factor support allowed);
- Absolute neutrophil count (ANC) >= 1.5 x 109/L;
- Platelet count >= 100 x 109/L;
- Serum creatinine =< 1.5 x ULN or creatinine clearance >60 mL/min;
- AST and alkaline phosphatase <2.5 x ULN if without liver metastasis and =< 5.0 x ULN if liver metastasis;
- Total bilirubin =< 2.0 x ULN;
- Prothrombin time (PT)/International Normalised Ratio (INR) within normal limits (WNL) unless therapeutically anticoagulated;
- Women of childbearing potential and men must be willing to consent to using highly effective methods of contraception (eg, hormonal contraceptives, bilateral tubal ligation, barrier with spermicide, intrauterine device) while on treatment and for at least 3 months thereafter;
- Males with the potential to father children must use two of the following methods of contraception acceptable for the study (e.g. hormonal contraceptives, bilateral tubal ligation, barrier with spermicide, intrauterine device) while on trial treatment and for at least 3 months thereafter.
- All female subjects of childbearing potential must have a negative pregnancy test (plasma or urine) result within 7 days before initiating study treatment;
- Baseline laboratory tests and tumor assessments must have been performed within 2 weeks before initiating study treatment;
- Subjects must be fully informed about their illness and the investigational nature of the study protocol (including foreseeable risks and possible side effects) and must sign and date an IEC-approved ICF before performance of any study specific procedures or tests.
Exclusion Criteria:
- Anticipation of need for a major surgical procedure or RT during the study;
- Treatment with chemotherapy, hormonal therapy, minor surgery, or any investigational agent within 4 weeks before study enrolment. Treatment with immunotherapy, biological therapy, or major surgery within 6 weeks before study enrolment. Treatment with RT within 1 week before study enrolment.
- History of any of the following conditions: diabetes mellitus requiring treatment with insulin or oral agents;
- Concomitant use of other TZDs;
- Myocardial infarction with significant impairment of cardiac function (e.g., ejection fraction =< 50%); severe/unstable angina pectoris; coronary/peripheral artery bypass graft; congestive heart failure; cerebrovascular accident (CVA) or transient ischemic attack (TIA), pulmonary embolism, or other clinically significant thromboembolic event; clinically significant pulmonary disease (e.g., severe chronic obstructive pulmonary disease [COPD] or asthma);
- Brain metastasis; an uncontrolled seizure disorder; spinal cord compression; or carcinomatous meningitis;
- Pleural or pericardial effusion. Subjects with minimal pleural effusion may be eligible upon request by Investigator and approval by Sponsor;
- Clinically significant active infection that requires antibiotic therapy or Human Immunodeficiency Virus (HIV) positive subjects receiving antiretroviral therapy;
- Pregnant or breast feeding;
- Known history of severe hypersensitivity reactions to any of the components of CS 7017 formulations;
- Serious intercurrent medical or psychiatric illnesses or any other conditions that in the opinion of the Investigator would impair the ability to give informed consent or unacceptably reduce protocol compliance or safety of the study treatment;
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00986440
Show 39 Study Locations
|Responsible Party:
|Daiichi Sankyo, Inc.
|ClinicalTrials.gov Identifier:
|NCT00986440 History of Changes
|Other Study ID Numbers:
|First Posted:
|September 30, 2009 Key Record Dates
|Last Update Posted:
|April 14, 2015
|Last Verified:
|April 2015
Additional relevant MeSH terms:
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases
Antineoplastic Agents


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2 Comments
'16 And Pregnant' Preview: Myranda Trevino Moves Into A New House
On the next episode on the hit MTV reality show, Myranda and Eric move into a dump of a house!
The next episode of MTV's 16 & Pregnant features Myranda Trevino realizing how much work she and her boyfriend Eric Kennemer have to do to their new house after a walk-through — they don't even have a fridge or a stove!
In the sneak preview, Eric's grandmother Nanny sees the messy house and she says, "Y'all better grow up fast."
With the arrival of their daughter, they have no choice but to grow up and fix the house — fast!
The show airs on May 1 at 10 p.m. EST — be sure to come back to HollywoodLife.com for our recap!
More '16 & Pregnant' News:


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Expedia-Verified Reviews
Don't miss out on a lower price on this hotel
Get an overview of this hotelHistoric hotel near the waterfront in Seattle
Popular property highlights
Guests say they love
- Proximity to public transit
- Onsite bar and restaurant
- Overall value of stay
- Overall room comfort
Minutes from Pike Place
Located in Seattle's financial district since 1928, Executive Hotel Pacific is a 5-minute walk from the waterfront. Guests can stroll to Pike Place Market in 10 minutes to watch fish vendors flinging salmon, and to the Space Needle in 7. Washington State Convention Center is 3 minutes away by cab.
Burgers, beers, and coffee
Guests can enjoy Pacific Northwest fare and gourmet burgers at The Lodge, as well as local craft beers and sports broadcasts. For light meals and gelato, guests can visit the café, and the hotel offers free coffee and tea. The cardio fitness room is great for those who like to work out while away.
Free WiFi, flat-screen TV
All guestrooms include free WiFi and 42-inch HC LCD TVs with cable channels, so guests can email, surf, and stay entertained. Soft duvets and pillowtop mattresses keep sleepers cozy, and the hotel provides convenient amenities including iPod/MP3 docking stations, irons, Keurig coffeemakers, and robes, plus a laptop-size safe for security.
Languages Spoken
- English
Executive Hotel Pacific
Hotel Amenities
Hotel Amenities
Dining options at the hotel include The Lodge, a restaurant, and Vovito Specialty Cafe. A bar/lounge is on site where guests can unwind with a drink. A 24-hour business center is on site at this 3-star property.
High-speed wireless Internet access is complimentary. This Seattle hotel also offers a fitness center, multilingual staff, and complimentary newspapers in the lobby.
Executive Hotel Pacific is a smoke-free property.
We have added dedicated concierge service, complimentary apples and water service in the lobby
- Bar/lounge 1
- Elevator/lift
- Fitness facilities
- 24-hour front desk
- Porter/bellhop
- Year Built 1928
- Tours/ticket assistance
- Restaurant 1
- Coffee shop or café 1
- Dry cleaning/laundry service
- Free WiFi
- Valet parking (surcharge)
- Smoke-free property
- Safe-deposit box at front desk
- Luggage storage
- Hair salon
- ATM/banking
- Breakfast available (surcharge)
- 24-hour business center
- Concierge services
- Total number of rooms - 155
- Number of floors - 8
- Number of buildings/towers - 1
- Multilingual staff
- Fireplace in lobby
- Free newspapers in lobby
Family Friendly Amenities
- Family Hotel
- Free Wi-Fi
- Refrigerator (on request)
- Microwave (on request)
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Languages Spoken
- English
- Spanish
Valet parking (surcharge)
Room Amenities
- Towels provided
- Linens provided
- Premium TV channels
- Premium bedding
- Air conditioning
- Free weekday newspaper
- Refrigerator (on request)
- Free bottled water
- Coffee/tea maker
- Microwave (on request)
- Daily housekeeping
- Bathrobes
- Hair dryer
- Iron/ironing board
- MP3 docking station
- iPod docking station
- In-room safe (laptop compatible)
- Cable TV service
- Blackout drapes/curtains
- Room service (limited hours)
- Connecting/adjoining rooms available
- Free cribs/infant beds
- Heating
- Free WiFi
Where to Eat
The Lodge - This restaurant redefines what it means to enjoy sports and local craft beer; 50 beers are available on tap. They pride themselves in the quality and heartiness of the food presented, from the gourmet Pac12 burgers to fine steaks and fresh seafood.
Vovito Specialty Cafe - Offers hand-crafted espresso, coffee, and beans in Premium Blend and Single Origin varieties. A full selection of gourmet teas, chai beverages, house-made gelato, sorbetto, a wide variety of paninis, salads and baked goods, all made fresh daily, are also available.
Nearby Things to Do
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Segway rental/tour nearby
- Mountain biking nearby
- Hiking/biking trails nearby
- Kayaking nearby
- Sailing nearby
- Scooter/moped rentals nearby
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
Hotel Policies
Check-in time starts at 4 PM
Check-in time ends at midnight
Minimum check-in age is 21
Special check-in instructions:
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! Up to 2 children 17 years old and younger stay free when using existing bedding.
- Rollaway/extra beds are not available.
- Free cribs (infant beds)!
- Pets allowed for an extra charge of USD 25 per pet, per night (maximum USD 200.00 per stay)
- 2 per room (up to 30 lb)
You need to know
Extra-person charges may apply and vary depending on property policy.
- Deposit: USD 50.00 per stay
Optional extras
- Breakfast fee: between USD 6 and USD 30 per person (approximately)
- Valet parking fee: USD 40.55 per night (in/out privileges)
- Pet fee: USD 25 per pet, per night (maximum USD 200.00 per stay)
Hotel Name
- Executive Hotel Pacific
- Executive Hotel Pacific Seattle
- Executive Pacific
- Executive Pacific Seattle
- Pacific Executive Hotel
- Executive Hotel Seattle
We should mention
Up to 2 children 17 years old and younger stay free when occupying the parent or guardian's room, using existing bedding. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.