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In 1990, a fire broke out in a house in Jacksonville, Fla., killing two women and four children. The husband of one of the women became the prime suspect, and that's when a fire investigator named John Lentini was called in.
At the time, Lentini says, the initial evidence pointed to a fire that was deliberately set. He calculated that it would have taken about 20 minutes for the house to become engulfed in flames — what's called a flashover — leaving plenty of time for someone to set the fire and get out.
But on a whim, Lentini noticed an identical house two doors down that was slated to be demolished. So he and his team refurbished the house and lit it on fire. It only took four minutes to get to flashover, and he realized the fire might not have been a set fire.
After the investigation, it was determined the fire was not arson and the charges were dropped against the husband.
For Lentini, that day was a seminal moment. He says that in the early days of arson forensics, the only science that happened was chemists looking for signs of gasoline on a piece of rug in the lab. In the field, investigators relied on anecdotal experience.
"If somebody would see an artifact and then find gasoline, they would make a connection," Lentini tells weekends on All Things Considered guest host Laura Sullivan. "And the next time they would see that artifact, they would just assume that gasoline must have caused [the fire]."
The problem was that anecdotal experience could lead an investigator to the wrong conclusion. In recent years, fire researchers and the changes to fire investigations have shattered dozens of arson myths as the science behind arson forensics continues to evolve.
"What I knew about arson, some of it was wrong," Lentini says. "What a lot of people thought they knew about arson was wrong."
Nobody ever set out to send an innocent person to prison for arson, Lentini says, but it absolutely has happened.
Old Cases, New Science
Doug Starr, the co-director of Boston University's Center for Science and Medical Journalism, recently wrote an article for Discover Magazine examining arson cases that relied on now-widely debunked theories about how fires start. In the few months of research he did on the story, Starr says he turned up at least two dozen cases.
One of the earliest cases was that of 16-year-old Louis Taylor, who was convicted of 28 counts of murder for setting the 1970 Pioneer Hotel fire Tucson, Ariz. Taylor was found with several matches in his pocket and fire investigators found what they believed to be evidence of two set fires in a hallway.
"Last year, at the behest of an attorney, several fire investigators looked back at the evidence and said it looked like a classic, accidental flashover fire," Starr tells Sullivan.
Taylor remains in prison, but Starr says the Arizona Justice Project is trying to get the case reviewed.
There might be hundreds of similar arson cases in the U.S., Starr says. In October, the Texas Forensic Science Commission asked that all arson cases in the state be reviewed. That amounts to between 750 and 900 arson cases in Texas alone.
Like Lentini, Starr says early fire investigations were based on apprentice-type knowledge passed down from the observations of previous investigators.
"The trouble is this is all based on observation and intuition, and science needs something more than that," Starr says. "Fortunately the new forms of investigation are based on actual laboratory science in which things are demonstrated to be true or not true."
Setting Fires At The ATF
Some of the newest research on how fires start and burn is now coming from the Bureau of Alcohol, Tobacco, Firearms and Explosives. The federal agency has always done a little fire research, but in 2003 it went all in with a new lab in Beltsville, Md., built just to burn things up.
On a recent visit, researchers were setting a diesel oil fire in their Fire Research Laboratory. The lab's chief, John Allen, says theirs is the largest forensic investigative tool in the world.
The room is massive and open, akin to an airplane hangar. Overhead, a 40-foot by 40-foot exhaust unit, similar to the one over your stove, sucks out the smoke and heat from the fires set in the lab to measure carbon dioxide and carbon monoxide, among other things.
The lab also houses a quarter-scale model of a living room complete with a couch, TV, chairs and a baby crib and toys. Allen says they use this to test fires, take measurements and time flashovers – how long it takes for flames to go from "a fire in a room to a room on fire."
"I would say because the presence of this laboratory, there has been leaps and bounds in advances in scientific knowledge," Allen says.
In another part of the lab, an almost completely finished trailer will be used for the other half of what the ATF does now. The lab recreates fires to help local investigators with actual cases where arson is suspected. In a few days, they're going to burn the trailer down.
"Every day, we're doing something new and different," Allen says. "Many days it is something cutting edge that's never been done before."
This year alone, the ATF's lab has recreated fires from three murder cases. In all of them, prosecutors ended up dropping the charges against the suspects because the lab determined what officials thought might have happened, actually didn't.
From NPR News, it's WEEKENDS on ALL THINGS CONSIDERED. I'm Laura Sullivan, in for Guy Raz.
In 1990, a fire broke out in a house in Jacksonville, Florida. Two women and four children died. The husband of one of the women became the prime suspect. Everyone thought it was arson. That's when a fire investigator named John Lentini was called in.
JOHN LENTINI: So I met with the captain and I looked at his evidence, and it looked like what passed for good arson evidence in those days.
SULLIVAN: Lentini looked for V marks on the walls to see where the fire started.
LENTINI: Shiny alligator blisters on the floor were a sign of accelerant.
SULLIVAN: He calculated it would take about 20 minutes for the house to become engulfed, something experts call flashover, plenty of time for the husband to set the fire. All the while, though, the husband claimed his innocence. Then, almost on a whim, Lentini noticed an identical house two doors down that was slated to be demolished.
LENTINI: So, what else could we do but burn it down? So, we refurbished the house and then we lit it on fire. Well, after four minutes, we had flashover in that room. And, you know, I was pretty shocked. I thought, oh, my gosh, this might not really be a set fire.
SULLIVAN: And it wasn't. They dropped the charges against the husband, and it was a seminal moment for Lentini.
LENTINI: What I knew about arson, some of it was wrong. And what a lot of people thought they knew about arson was wrong.
SULLIVAN: That's our cover story today: the changing science of fire investigations and how what may once have been considered science wasn't, in fact, science at all.
LENTINI: The only science that anybody thought about was the science that happened in the laboratory when chemists would look for gasoline on the living room rug. The rest of it, it was art.
SULLIVAN: Where did all of these old ideas of how fires started come from?
LENTINI: Anecdotal experience. I mean, nobody ever set out to send an innocent person to jail. But if somebody would see an artifact and then find gasoline, they would make a connection. And then the next time they'd see that artifact, they just assume that gasoline must have caused it.
SULLIVAN: Do you think that means that innocent people have gone to prison?
LENTINI: Oh, absolutely.
DOUG STARR: The few months of research I did on this turned up at least two dozen cases.
SULLIVAN: That's Doug Starr. He's the co-director of Boston University's Center for Science and Medical Journalism. And he recently wrote an article for Discover Magazine examining arson cases that relied on now-widely debunked theories about how fires start.
STARR: One of the earliest cases was a 16-year-old named Louis Taylor. He was convicted of setting the infamous 1970 Pioneer Hotel fire in Tucson. He was convicted on 28 murder counts based on the then fire investigator's observation that at opposite ends of a hall, there were severe areas of burn.
At the time, it was thought that the area of the deepest burn must be where the fire started because it burned there the longest. And working backwards from that evidence, they figured that because they found Taylor with several matches in his pocket, he must have set those two fires and they must have been set independently.
Last year, at the behest of an attorney, several fire investigators looked back at the evidence and they said this looked like a classic accidental flashover fire, which you do get deep burn areas in separate areas not because they were set but because that's what ventilations sometimes does. But Taylor is still in jail.
SULLIVAN: Really?
STARR: Yeah. The Arizona Justice Project is trying to get the case brought up. But these cases are extremely hard to get re-reviewed.
SULLIVAN: How many cases do you think are there out there?
STARR: The investigators I speak to say that there may be hundreds out there. For example, you all know about the Willingham case in Texas in which Cameron Todd Willingham was executed for, you know, burning a house and killing his children. The Texas Forensic Science Commission, in reviewing that, found that that was not a good decision. And just at the end of October, they said that all cases in Texas have to review. We're talking about between 750 and 900 arson cases in Texas alone.
SULLIVAN: Have you noticed any common threads?
STARR: Yes. First of all, it must be said that everybody means well. Everybody's doing the best that they could do. But for generations, fire investigations have been based on kind of folklore, apprentice-type knowledge in which a fireman may be consigned to the investigative unit and he or she will learn classic signs of arson from the person who came before. The trouble is this was all based on observation and intuition. And science needs something more than that. And fortunately, the new forms of investigation that are emerging are based on actual laboratory science in which things are demonstrated to be true or not true.
SULLIVAN: What are some of the new techniques that are being used now?
STARR: It's really interesting. Scientists are analyzing smoke detectors. It turns out that when a smoke detector goes off, you know that high-pitched siren sound it makes?
SULLIVAN: Mm-hmm.
STARR: That causes a kind of sound vibration that causes tiny particles to accumulate in particular patterns around the sounding horns. So by analyzing that, they could get a better idea for how long a smoke detector was going on or if it went off. So, this is all science. It's been quantified in the laboratory. People can attach numbers to it. It is outlined in professional standards. And given time and money, people can analyze a fire pretty well nowadays.
SULLIVAN: Some of that newest research on how fires start and spread is now coming from ATF. The federal agency's always done a little fire research. But it went all in in 2003 with a new lab in Beltsville, Maryland, built just to burn things up.
JAMIE LORD: He's measuring out the diesel fuel now into our little graduated cylinders here.
SULLIVAN: Jamie Lord is one of ATF's fire research engineers.
LORD: You put a little gasoline in there, Jimmy?
JIMMY: Yup.
LORD: Yeah, he spiked it with a little gasoline. So if you poured diesel into a pan and tried to light it with just a match or a lighter, you'd be here all day.
SULLIVAN: ATF runs these experiments all day long to study heat, combustion, burn times.
LORD: Yeah.
SULLIVAN: That's really a lot of smoke for just a small pan.
LORD: Yup.
SULLIVAN: The researchers say they're pretty used to smelling like they're at a never-ending barbecue. John Allen is the chief of fire research here and he gave us a tour.
This is a very large room. This is like an airplane hangar.
JOHN ALLEN: This is the largest forensic investigative tool in the world.
SULLIVAN: And I have to say, this is the largest upside-down cone I have ever seen in my life.
ALLEN: Well, basically, this is a 40-by-40-foot inverted cone over our head, which when we set a fire here acts to pull that smoke out of the room, and the heat, to measure carbon dioxide, carbon monoxide and things of that nature. And what you see here is actually a quarter-scale model of a room...
SULLIVAN: It's a living room.
ALLEN: It's a living room with a couch, a couple of chairs, a TV set on a small bookcase and a crib with a few stuffed toys in there. As we set a fire in this room, what will happen is the fire will begin to grow. Cool air comes in from the bottom. The hot air and hot gases will start escaping out of the top. As the fire gets bigger, more and more heat will start pooling at the ceiling and fire will start extending out, but then the heat radiating down from all that burning gas above will start catching everything in the room on fire, which is a transition phase that we call flashover, which is essentially going from a fire in a room to a room on fire.
Once you go into a flashover stage, all the original patterns and things like that on the wall can now be changed and obliterated. You can't walk in and look at the scene and say, well, I know the fire started here because of this damage. Because, no, the whole room was so severely damaged that you have to do much more processing.
SULLIVAN: Is that different from the way fire was understood 10, 20, 30 years ago? Do you think it's made sort of leaps and bounds in the past 10 years?
ALLEN: I would say because of the presence of this laboratory, yes, there has been advances in scientific knowledge. For example, if I take a cigarette and throw it in gasoline, it'll go out.
SULLIVAN: Oh, but they have it in all the movies!
ALLEN: That's TV. That's exactly right. That's the "CSI." Exactly, that's TV.
SULLIVAN: That's how you make a gas tanker blow up, right?
ALLEN: And I'm sorry I'm going to dispel that myth, but we have done thousands and thousands of tests with cigarettes and gasoline to try and get cigarette to ignite gasoline. We have not been successful yet. But it's - I didn't say it's impossible, so don't try it.
SULLIVAN: Yeah.
ALLEN: Because you may be the one that actually finds that, hey, I did get it to happen.
SULLIVAN: What do you think are some of the great - other great myths that you've dispelled in this lab?
ALLEN: Oh, a couple of old ones, spalling of concrete, which is...
SULLIVAN: What is spalling of concrete?
ALLEN: If you look at a concrete floor after a fire and you see chunks and slabs all broken up across the concrete, well, that was an indication that somebody poured gasoline on there.
SULLIVAN: Oh.
ALLEN: No. It just means there was moisture in the concrete. And we all know now that that myth from 40 years ago is not true.
SULLIVAN: Next to the living room is another structure, an almost completely finished trailer. John Allen says this is the other half of what ATF does now, it recreates fires to help local investigators with actual cases where arson is suspected. In a few days, they're going to burn this trailer down.
ALLEN: This used to be the combination kitchen area and living room area where there was a couch. We had a mock-up refrigerator. We actually go out to wherever we can to find the materials like the couches and things like that to bring them in here and set the fire up.
Some cases, like this room was not actually involved in a fire, but because the smoke and the heat progressed to the trailer, then we have to build all those different areas to include them in there, to mimic what was really there. We have our crew assembled with all the materials we need here to quickly put things together and to answer those specific questions that may come up. Again, we're not the actual fire investigators. We're the engineers and scientists that support...
SULLIVAN: Yeah. Do you ever get tired of building things that you're just going to burn down?
ALLEN: I couldn't think of a more fun job in the world, to be able to come in and every day, we're doing something new and different. And many days, it's something cutting-edge that's never been done before.
SULLIVAN: This year alone, this lab has recreated fires from three murder cases. In all of them, prosecutors ended up dropping the charges against the suspects, because the lab determined that what officials thought might have happened when the fire started actually didn't. Transcript provided by NPR, Copyright NPR.

subset: commoncrawl


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1. Re: Is a Pentium 4 a Dual core?aguilera2000 Dec 16, 2009 3:40 PM (in response to pasadenaman)
631 is NOT dual core. however you can activate HT on bios set up screen and then your computer will see it as 2 cores.
read about it here
2. Re: Is a Pentium 4 a Dual core?theonerm2 Dec 30, 2009 9:05 PM (in response to pasadenaman)
Some Intel Pentium 4 processors have hyperthreading technology which allows the operating system to see one core as two and you get two cpu graphs in task manager. One could mistake the Pentium 4 HT CPU for a dual core processor by looking at the task manager but it is in fact not a dual core processor. Actually the purpose of hyperthreading technology is to use the cpu more efficiently and it works making the cpu up to 30% faster. How does it work? Hyperthreading allows two threads to run at once like a dual core cpu but the 2nd thread can only run on unused resources on a Hyperthreading Pentium 4 while dual core cpu's have a whole extra core for the 2nd thread.
Example of how single core, hyperthreading, and dual core cpu's work: Imagine that you only have one hand and you have to pick up rocks and put them in a pile. Now these are fairly big rocks you can only fit one rock in each hand. Like a single core cpu you can only move one rock(thread) at a time. It's a very slow process so now you're probably thinking of a way to do it faster and here is where hyperthreading comes in. You realize that you might be able to pick up two rocks by scooping them up with your arm. You can carry two like this and it's much faster than carrying just one but it's heavy and you might drop them and you'll have to pick them back up. Now if you had two hands you could carry two rocks much faster and easier this is dual core. One rock in each hand isn't as hard as 2 rocks in one hand so it's easier and more efficient.
The simple fact is that they either scammed you or made a huge mistake. First of all Pentium Dual-core processors even now don't reach clock speeds of 3GHz. Next How could they not know they were selling you a Pentium 4? I would think they should know their products or at least hire people qualified for the position. Whoever sold you that computer was either scamming you or they were just completely ignorant about computers in which case they should not have been working there in the first place. If that store advertised that computer as having a Pentium Dual-Core then it is illegal and it doesn't matter if they made a mistake or not it was still false advertisement and that is illegal. And if they really didn't know it wasn't a Pentium 4 then they shouldn't be selling computers.
3. Re: Is a Pentium 4 a Dual core?xB2Spiritx Jan 1, 2010 11:41 AM (in response to pasadenaman)
Pentium 4 is under netburst Microarchitecture. which uses higher clock speed, higher power and more heat.
compared to core
Intel Core family are from Core microarchitecture. uses low clock speed but many memory and hyper threading abilities which make it fast
4. Re: Is a Pentium 4 a Dual core?CheesiePie Mar 12, 2010 8:56 PM (in response to pasadenaman)
My PC appears to be running on two Pentium 4 CPUs, I never thought Intel made Pentium 4 into a dual core CPU. In my DXDIAG, under 'processor', it says "Intel(R) Pentium(R) 4 CPU 3.00GHz (2CPUs)". So what exactly do I have here? A dual core Pentium 4 or just two Pentium 4 CPUs packed together? Sometimes this PC runs slow and I just can't convince myself that it actually has 2 CPUs, or just a dual core CPU or whatever it is.
5. Re: Is a Pentium 4 a Dual core?aguilera2000 Mar 13, 2010 10:24 AM (in response to CheesiePie)
You have a SINGLE CORE CPU, 1 CORE ONLY... some of the PENTIUM 4's use Hyper-threading technology (HT), this makes your CPU work as if it were 2 but it only emulates a second one. Yes your PC reads it as if had 2 cores installed but in reality you only have one. pentium 4 3.0ghz HT(1core) will never be as fast as dual-core 3.0ghz (2cores). Hope this helps...
6. Re: Is a Pentium 4 a Dual core?CheesiePie Mar 13, 2010 9:52 PM (in response to aguilera2000)
Nice to finally end the confusion of what type of CPU I really have. I'm only lacking 3 more cores to play bad company 2 properly.
7. Re: Is a Pentium 4 a Dual core?aguilera2000 Mar 13, 2010 10:26 PM (in response to CheesiePie)
In reality chances are you PC will not support a quad CPU, you will probably have to upgrade your mother board first, and then it depends A LOT on your graphics card and ram as well, you best option to play bad company on a medium setting will be to upgrade you pentium 4 cpu to a nice affordable core2duo something like a E7600(low budget) or a core2duo E8200 8300 even the E6xxx series will duo way better (much much better) than the pentium 4 you have installed now and you can buy them now for around $50-80 bucks. but make sure your mother board can handle such CPUs before you buy.
by the way, what are the specs on your PC?
8. Re: Is a Pentium 4 a Dual core?CheesiePie Mar 14, 2010 7:53 PM (in response to aguilera2000)
I can play Bad Company 2 on low settings, with medium textures and high shadows, but around 20 frames per second, sometimes 10s. In fact, I just completed the campaign, the game was actually playable. Besides the Pentium 4 CPU, I have 2GB of RAM, XFX 8800GS graphics, motherboard appears to be a Dell OMH651(whatever that is), and I use Windows XP 32-bit Professional SP3. From stock, which is a 4 year old Dell Optiplex 320, I only added the 8800GS graphics card and the extra 1GB of RAM, it was never meant to be a gaming PC. I was surprised I actually installed the 8800GS into this computer, it lacked voltage from the power supply, the card needed 500, power supply only put out 350, I'm guessing this card can do better with enough power. The RAM was a bit of trouble, this computer wasn't compatible with 800MHz RAM, only 533MHz and 667MHz RAM could be fitted. I'm able to play Crysis on halfway medium settings with average 20 frames per second, and I can play Moder Warfare 2 with medium settings at least 30 frames per second, both on 1280x960 resolution.
9. Re: Is a Pentium 4 a Dual core?Manjit Mar 15, 2010 6:08 AM (in response to pasadenaman)
I guess you already have got your answer. If you have any nagging question about Intel product and technologies, you can get instant answers to them from Intel experts at Intel Live Chat. More Info @ www.intellivechat.comConnect with Intel on Skype@IntelLiveChat
10. Re: Is a Pentium 4 a Dual core?2forthend Jan 19, 2011 7:43 PM (in response to pasadenaman)
11. Re: Is a Pentium 4 a Dual core?werez Jan 20, 2011 7:12 AM (in response to pasadenaman)
That had to be the worst purchase of your life. I bought a PC like that in 2004.
Pentium 4 is so bad that even ultra-low voltage mobile CPUs offer much better performance.
It's a very old platform, so it doesn't make any sense to upgrade.
Take a look at this list to get a better idea about CPUs and their performance:


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Fred H. Reiss
To the editor:
Randy and I had just finished adjusting the valves on Ron's 502 cubic inch, 500+ horsepower jet boat. Ron stepped into the boat with the life vests and three helmets. He and Randy were sitting in the front and I had the back seat. We all put on our helmets and vests. Ron hooked up the kill switch, idled out a short distance past the No Wake Zone, and slammed the accelerator to the floor.
In what seemed to be about two seconds, we were on plane and flying across the lake at 68 mph! That's fast when you're as close to the water as we were and I was instantly reminded of the videos of boats that take off airborne, tumble, crash, and end up as thousands of pieces of floating debris. But this was Ron's maiden voyage with his new boat and we took it pretty easy the rest of the day.
As we headed out to dinner that evening, I noticed I was the only one wearing a seat belt. When I asked Randy why he wasn't wearing one, he said, "Fred, I don't like to be told I have to wear one. I have a right to make that choice for myself." When I asked him why he wore a life vest and helmet in the boat, he said, "That's different. "When I asked what was different, he didn't answer but said, "Fred, I figure when it's your time to go, it's your time." I was really surprised with how quickly I came back with, "Randy, why is it you take Lisinoprol for your blood pressure if you believe "when it's your time to go, it's your time." Randy said, "Good point, Fred. But you won't change my mind."
In the Aug. 21 edition of the Bolivar Herald-Free Press, the woman who died in a crash near Pleasant Hope was described as "Troop D's 57th fatality for 2013" and not wearing a seat belt. Actually, this was the 75th fatality and the facts for many of these can be found on the Missouri State Highway Patrol Crash Report Website at: www.mshp.dps.mo.gov/HP68/SearchAction?searchTroop=D.
If you look at the last 10 fatalities, eight were not wearing seat belts and three of these had been ejected from the vehicle. If you want to see the hard facts to support wearing a seat belt, look at the "Fatal" and "Serious" injuries and see how many individuals weren't buckled up.
This reminded me of the tragic loss of a young girl's life in Hickory County when she was ejected from the vehicle after a crash at the intersection of Highway D and County Road 220. Of the four occupants, she was the only fatality and the only person not wearing a seat belt.
Google "Seat Belt Statistics" and you'll find all the facts to support their use. Here are some of them:
n In 2008, 64 percent of the occupants ages 13 to 15 and 21 to 34 killed in a crash were not wearing a seatbelt.
n In fatal crashes in 2008, 77 percent of the occupants that were ejected from a vehicle were killed. Ejection is the most injurious event that can happen to a person in a crash.
n In 2009, seat belt use saved an estimated 12,713 lives.
n You are 10 percent less likely to wear a seat belt if you live in a rural area.
n Parents who don't wear seat belts set a bad example and their children are less likely to wear one. Consider the grief a parent might experience when they lose a child who could have survived if they had used a seat belt.
n Driving a pickup truck or SUV doesn't exclude you from the law or make you any safer in a crash.
Please consider your safety and set a good example for the occupants in your vehicle. Wearing a seat belt, once the habit is formed, isn't any more difficult than putting the keys in the ignition, starting the engine, and shifting into drive. It becomes second nature, you'll hardly notice it, and you may be very thankful someday that you did.


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Russian NGO forcibly evicted from Moscow office
MOSCOW (AP) — Law enforcement agents forcibly evicted the head of one of Russia's leading human rights groups and about a half dozen others from his Moscow office early Saturday, in the latest attack on a Russian non-governmental organization.
Lev Ponomaryov, 72, who heads For Human Rights, said he was beaten all over his body when security forces stormed the building at around 2 a.m. and dragged him out. Dozens of riot police had raided the office on Friday and ordered employees to leave, but they had refused.
Russia's human rights ombudsman, Vladimir Lukin, said the NGO was evicted illegally from the city-owned property. The organization has had difficulties extending the lease, but Lukin said it had the right to remain until the issue was resolved in court.
The U.S. democracy watchdog Freedom House condemned the "violent assault" and called on the international community to "register its strong opposition to such thuggish tactics."
For Human Rights is one of hundreds of Russian non-governmental organizations that have come under pressure in recent months as part of President Vladimir Putin's crackdown on dissent following unprecedented street protests last year.
Many organizations have been raided to check compliance with a new law that requires all NGOs that receive foreign funding and engage in vaguely defined political activities to register as foreign agents, a term that carries Cold War connotations of spying. Putin has accused the U.S. State Department of funding Russian NGOs with the aim of undermining his government.
Ponomaryov, with what appeared to be a bruise under his left eye, returned to the street outside his office on Saturday afternoon to speak with supporters. He said doctors had counted dozens of small bruises on his body as the result of a "rapid-fire beating" as he was being dragged across the floor.
Moscow police said its officers were at the scene, but the forced eviction was carried out by a private security firm. Sergei Mitrokhin, the leader of the liberal Yabloko party, who was among those evicted, said the operation was directed by a man in plainclothes who appeared to be a security services officer, the Gazeta.ru news portal reported.
Amnesty International said it sent a representative to Ponomaryov's office on Friday to observe the raid.
"In Russia, we have witnessed how authorities are using every trick in the box to stop human rights activists criticizing their policies," the group said in a statement. "The attempt to evict For Human Rights from publicly owned offices seems to be yet another attempt to block their important human rights work."


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[Mobile? Click Here for Video]
Vodafone has posted a video on their YouTube channel featuring the sexy new BlackBerry Bold 9000. When should you expect to see this gem? We reported last month that Vodafone would be carrying the Bold 9900 but there has been some debate as to a certain launch date. Rumors have stated from mid August to sometime in the month of September. Either way, both rumors are still a ways off for those who are dying to get their hands on this new Bold device. Now for a few details from Vodafone:
The BlackBerry Bold 9900 is perfect for tapping out quick messages as well as detailed emails. That's because it gives you a touchscreen plus a full QWERTY keypad with larger keys than you'll find on the BlackBerry Bold 9780. The Bold 9900 also comes with a powerful 1.2GHZ processor that makes browsing the web a breeze where connection speeds allow. And whether it's your mate's party or your sister's wedding, you can capture your magic moments in pin-sharp high definition video.
You can buy the BlackBerry Bold 9900 from us when it launches.
Just register your details here - BlackBerry Bold 9900 smartphone ? coming soon to Vodafone - and we'll send you the latest information as soon as we get it.


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A couple of minutes walk away from Piazza Benedetto Cairolo and San Carlo ai Catinari, is the church of Santa Maria in Monticelli.
Friday, March 4, 2016
Santa Maria in Monticelli
A couple of minutes walk away from Piazza Benedetto Cairolo and San Carlo ai Catinari, is the church of Santa Maria in Monticelli.
Helpful Hints
Getting Around
I found walking around Rome was the best way to see everything but the metro, trams and buses are an easy and cheap option also.
Most buses and metros do get crowded and tickets must be bought before boarding and validated when you first get on but it is a great way to get around and see Rome if you are short on time or suffer from sore feet.
Buses #40 and #64 starts at Termini and ends near St. Peter's traveling past other places of interest, returning the same way.
Bus #75 takes you past the Colosseum
Bus #910 takes you to Villa Borghese
#64 & #40 Express Bus
Piazza Venezia
Corso Vittorio Emanuele II
Campo de'Fiori
St. Peter's
The Electric buses that are around Rome can travel into the older parts of the city and wind around the narrow streets. Bus #116 travels though the streets of Centro Storico.
Ticket Options
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Thanks to an inspired collaboration between Air New Zealand and the country's top-tier wineries, oenophiles can hit New Zealand's wine trail before they land.
Air New Zealand's Business and Premium economy sections are like a boutique hotel in the sky, artfully blending style and quirky humor. While their 2012 security film, trading on director Peter Jackson's box office-shattering translation of J.R.R. Tolkien's epics, prepping passengers for their journey to "Middle Earth" went viral on YouTube and is now the stuff of legend, travelers from the U.S. now are treated to a "safety in flight film" starring U.S. television legends Gavin McCloud and Betty White in a scenario that blends Cocoon with
Hot in Cleveland.
The wine program, curated by Jim Harre, international wine judge, hotelier and Air NZ's In Service Flight Director and Wine Consultant, and Foxes Island Winery owner John Belsham, goes far beyond providing a sexy flourish for restaurant-caliber cuisine created by chefs such as Peter Gordon, who is known internationally and appeared on television shows such as
Globe Trekker. It is a proper showcase for the wineries that has endured for over 25 years in tandem with
New Zealand Winegrowers.
Wineries featured include several whose wares are in distribution in the U.S. market, including Marlborough's Brancott Estate (a Pernod Ricard– affiliated winery) to
Villa Maria (whose wines are distributed by Ste. Michelle Wine Estates, and whose vineyards in Marlborough and Hawke's Bay are top draws along New Zealand's "Wine Trail") to
Peregrine Wines in the Central Otago (one of the southernmost wine production regions in the world, with product brought into the U.S. by Vineyard Brands in Birmingham, AL).
According to a marketing spokesperson for Air New Zealand, the airline twice a year conducts an extensive tasting, inviting and encouraging all of New Zealand wineries to submit their product for consideration as an in-flight selection. There are several important conditions to consider when selecting wines for drinking in-flight, such as low humidity and high altitude, which will impact the palate, as the wines' tannin and astringency will be more pronounced. Once short lists have been made for each varietal required by the team led by Harre and Belsham, negotiations take place with the wineries.
However, does this painstakingly organized beverage program and its guide help the efforts of New Zealand's wineries and their agents to deepen their inroads into the U.S.? To get some insight, we caught up with representatives from several New Zealand wineries whose wines have been selected for first-class exposure on Air New Zealand. While passenger-to-friend word-of-mouth certainly perpetuates a demand for New Zealand's classic Sauvignon Blancs, Pinot Noirs and newer developments captured in a bottle, representatives from the different wineries candidly discuss how their participation has helped their brand take flight internationally.
"Through the years, we've found the exposure to a variety of consumers from all over the world is great not only for the New Zealand wine industry but also the New Zealand tourism industry. As Villa Maria has an added advantage of being located five minutes from Auckland International Airport, visitors who have tasted our wines on the plane will stop by at the beginning or end of their trip to taste the rest of the range. Because Villa Maria has a strong global distribution network, Air New Zealand's program is a really impactful way for people to find a wine they enjoy and then be able to find it in their local market."
Barbara Lawson, owner of Marlborough-based winery Lawson's Dry Hills (distributed in the U.S. by The Country Vintner in Ashland, VA), praises the program's thoroughness in helping her wines generate a consistent stream of awareness and demand in the U.S.
"When passengers have tasted New Zealand wine on an Air New Zealand flight inbound, they use the information contained in the wine guide booklet to seek out wineries in the area they are visiting," Lawson explains. "We are no exception, as our cellar door [New Zealand speak for tasting room] experiences visits from the Air New Zealand passengers, and their visit to the winery reinforces their initial enjoyment of our wine. We then give them advice where in the USA they can buy our wine on their return home.
Neal Ibbotson, owner of Marlborough-based Saint Clair Family Estate (a New Zealand viticulture pioneers established in 1978, and distributed here by Winesellers Limited in Niles, IL), is also pleased at how effectively the program has enhanced brand perception for both his own brand and for the overall New Zealand wine industry. Furthermore, he credits the program for helping the Saint Clair brand achieve parity with Air New Zealand's excellent reputation for customer service and on-board food and beverage.
"With an airline that places enormous focus on excellence, the in-flight wine program representation of Saint Clair is one of the many ways of educating Saint Clair consumers and giving them increased confidence in purchasing the Saint Clair wine brand," says Ibbotson. "It is also a way to introduce the Saint Clair wine brand to new customers with the aim for these customers to potentially becoming loyal Saint Clair consumers who are in-turn able to introduce further people around the globe to Saint Clair. Passengers being exposed to Saint Clair enhances brand perception and, in turn, increases sales across Saint Clair's entire portfolio of wines with trade and consumers."
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text: The Lansing Lady Lions took their dual at Immaculata 6-3 on Tuesday. "We had some good showings in a few matches, but we were not consistent enough across the board to take more than the three wins," said Immaculata head coach Manuel Hernandez. The No. 1 Immaculata doubles team of Sydney Simek and Liz Lee lost a close match to Lansing's Katie Rathjen and Colby Mortinsen 8-7(7-3). "Simek and Lee had a few opportunities to close out their match against Rathjen and Mortinsen, but they could not put the game wins back to back and they found themselves in a tiebreaker," Hernandez said. "A mental error caused us to lose track of the scoring, and when a few unforced errors made their way into the match, Syd and Liz found themselves on the short end of the score." The No. 2 doubles match went to Lansing's Sydney Chiles and Rachel Long 8-2, but Immaculata's No. 3 doubles team of Priscila Hernandez and Elena Nine beat Ashley Miller and Sara LaMoe 8-6. "Both teams had opportunities throughout the match until Priscila and Elena stepped it up just a little more in order to take the win," Hernandez said. "The pair played hard and moved well throughout the match, with Priscila covering the base line extremely well." Four of the singles matches went Lansing's way. Rathjen, Long, Miller and LaMoe came away with victories for Lansing. Lee and Abby Meirose took wins for Immaculata. Liz and Colby were at two-all when Liz started to make her move and she steadily built up a cushion as she finished the match by winning the last four games in a row," Hernandez said. "Her baseline ground strokes were strong and she covered the court very well today." Hernandez said Meirose was down 5-2, but came back to win 8-6. "She closed out the match well and that is something all the girls need to be able to do," he said. Even though Meirose was able to finish her match strong. Hernandez said it isn't a strength of the entire team. "We have some things to continue to work on, especially closing out matches," he said. The varsity squad will travel to Sabetha for a quad on Thursday, which will also include Marysville and Topeka-Hayden.


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Older S-10's
Hi everyone! I hope this discussion takes off and becomes a good source of info on older S-10 trucks and a source of comraderie for owners of them.
A bought a white, 2 WD, 1989 S-10 with the Tahoe Package on July 16, 2001. The truck had 134,502 miles on it at the time of my purchase. My truck has the 2.8 V6 and a five speed transmission. It also has air conditioning, which works very well.
This truck was a "rebuild," having been bought from an insurance pool by the dealer from whom I bought it. This is my first experience with a salvaged vechicle, and it has certainly been a pleasant one so far!
I suppose older vehicles are commonly totalled by insurance companies for very little actual damage. This was apparently the case with my truck. The dealer told me that it had sustained only a couple smashed fenders and nothing more than just cosmetic damage.
I was able to buy this truck for $2450.00 with tax and license included! It looks almost like a brand new truck. Even the interior is in great shape, except for splits in the vinyl seat on the drivers side. I am having the bench part of the seat re-covered next week.
I'll bet I would have had to pay $1000 more for this truck, had it not been a salvage.
I have put almost 2000 miles on the truck, and the oil level is still exactly on the full mark on the dip stick! I plan on changing oil every 3000 miles, so I already know that I won't have to add oil between changes.
The gas mileage has been anywhere from 23.2 for a low to 24.1 for a high with my normal mix of driving, and it was 25.6 on a tank of gas that included one longer trip than my normal commute.
I totally love this little truck, and I consider it a steal for the price I paid.
I have had the U joints changed, which took care of a vibration that I had noticed. I have also had a chip on the windshield repaired so that it wouldn't spread.
I am very proud of that little truck, and it looks like it will make a great daily driver.
Let's hear about YOUR old S-10.
A bought a white, 2 WD, 1989 S-10 with the Tahoe Package on July 16, 2001. The truck had 134,502 miles on it at the time of my purchase. My truck has the 2.8 V6 and a five speed transmission. It also has air conditioning, which works very well.
This truck was a "rebuild," having been bought from an insurance pool by the dealer from whom I bought it. This is my first experience with a salvaged vechicle, and it has certainly been a pleasant one so far!
I suppose older vehicles are commonly totalled by insurance companies for very little actual damage. This was apparently the case with my truck. The dealer told me that it had sustained only a couple smashed fenders and nothing more than just cosmetic damage.
I was able to buy this truck for $2450.00 with tax and license included! It looks almost like a brand new truck. Even the interior is in great shape, except for splits in the vinyl seat on the drivers side. I am having the bench part of the seat re-covered next week.
I'll bet I would have had to pay $1000 more for this truck, had it not been a salvage.
I have put almost 2000 miles on the truck, and the oil level is still exactly on the full mark on the dip stick! I plan on changing oil every 3000 miles, so I already know that I won't have to add oil between changes.
The gas mileage has been anywhere from 23.2 for a low to 24.1 for a high with my normal mix of driving, and it was 25.6 on a tank of gas that included one longer trip than my normal commute.
I totally love this little truck, and I consider it a steal for the price I paid.
I have had the U joints changed, which took care of a vibration that I had noticed. I have also had a chip on the windshield repaired so that it wouldn't spread.
I am very proud of that little truck, and it looks like it will make a great daily driver.
Let's hear about YOUR old S-10.
I am having a lot of fun fixing small things on that S-10. I am no mechanic by any stretch of the imagination, so I just take care of the simple things.
I went back to the dealer where I bought it the other day and asked if he had a better beauty ring than the worst one that I had on my truck. He let me search through a pile of wheel covers and beauty rings, and I found one that was in real good shape. He let me exchange mine for that one and did not charge me anything.
I had the U joints changed at a little shop down at the end of my road, and I hung around and watched them do the work. I really enjoyed watching them do that and talking to them.
I went to a junkyard to look for a seat, but they only had a cloth one in the right color (burgundy) and I want to stay with vinyl.
I have bought some nice looking floor mats for it.
I just like to do stuff like that.
Don't everyone post all at once now. This thing is going over like a lead balloon, huh?
Oh well, I guess I can always post messages to myself here.
Bought a new CD player for the S-10 today. It had a factory am/fm with cassett, and the radio kept going to static for long periods and then would come back.
I got a Pioneer Premier DEH-230 receiver/cd palyer and had them install a powered subwoofer also, a Clarion PSW160. I still need to upgrade the dash speakers for some better high frequency sound. I think I can change those out myself, so I might just get them mail order or something.
I ended up with a pretty decent sound system after spending $539.98. It isn't world class or anything, but it sounds pretty good.
Filled the truck up today and got 24.4 MPG with just my regular driving mix on that tank.
Still lovin' that little truck!
Any stereo experts wanna recommend a good 4 x 6 repalcement speaker for my dash? That's the next thing I wil do to upgrade my sound system (and hopefully, the last).
All I have now is the two factory speakers in the dash and the powered subwoofer mentioned in the previous post.
The guy at the sound shop said that upgrading those dash speakers would be the best step to take for an improvement. You experts agree with that?
I've got all the bass that I want now, but I can tell that there is room for improvement in the mid and high range, especially the high range.
quadrunner500 Posts: 2,728127,000 miles on our '90 S10 Blazer. Still going strong! 4.3L V6, everything works!0
Thanks for the post. I thought no one was ever gonna post in here.
Glad to hear that you are having such good luck with that Blazer. I had a 92 Jimmy 2 door 4 x 4 that I dearly loved, but I totalled it back in 1995. It was medium gray metallic, and I thought it was beautiful. It had the throttle body 4.3 L.
Keep posting!
I bought an S15 in '88. First year with the 4.3, and only available with an auto. Wish I still had it as it was a blast to drive. Added the front stabilizer bar, but the real trick for handling was in the frame to bed mount. I had the short bed regular cab. The bed was mounted at the four corners to the frame, but there was another cross brace in the middle of the bed that was not bolted to the frame. Really no need to. But if you did bolt it to the frame, and the holes were in the frame to do so, it reduce the flex in the frame quite a bit. I had Goodyear Eagle GT's, stabilizer bar, bed mount mod, the 4.3, and when all was said and done, a good handling little rocket!
Mines the big one on the right (00 Silverado)
The one on the left is my dads 92 S-10. Red cab 4.3 V-6. Is about to turn 100K real quick. Runs great. About 2 more yrs left (until he retires) then it goes to my lil bro (15 now) and he will finish the thing off hehe
Great truck i drove it for awhile but had to step up to a fullsize.
Thanks for your posts, guys. Maybe this discussion will take off after all. Hope so.
That looks like a nice little S-10, ryanbab. Any other pics of it that show more of the truck? (Nice Silverado, by the way!)
sorry i cant post pics directly in here because picturetrail wont let me
Check out
there are pics of it in there0
I tried that link, and picturetrail has a message that the part of their site that I am trying to get to is under repair.
I'll try later.
Well, people, I just couldn't stand having those new goodies and not getting the most out of them, so I had a pair of Rockford Fosgate HPC1246's installed to replace the factory speakers in the dash.
I paid $120.00 with tax and installation, and the MSRP listed on RF's web site is $130.00. I guess I got a decent deal.
They did make a nice difference in the sound quality. I had great bass, but very weak mid and high range with just those factory speakers. Now I'm in good shape over all.
These speakers have a built-in dome tweeter and are deeper than the factory speakers. This meant that the speaker covers would not go back on exactly flush with the dash board. They have a little hump in the middle, which doesn't bother me much, since they have made such a difference in the sound quality.
I have ended up spending $660 on the stereo equipment all together. Hope I got the most "bang for the buck," but I am a total novice as far as this stuff is concerned.
I know that you can spend a fortune on that stuff, but I couldn't go that route. I just wanted something decent, and that's what I have now. I was wanting at least the equivavlent of a real good factory system, and I have that and then some.
Let's have some posting!
Would like to have an owners manual for my S-10, since it did not have one when I bought it.
I called the GM dealer, and they said I would have to order one from Helm, Inc.
I checked on it, and they want $20 plus $6.50 shipping. I guess that's not too bad, but I don't know if I want one that bad or not. I am going to check a junkyard today to see if I can find one.
If anyone is interested, you can go to www.helminc.com and order an owners manual.
S10 long bed with 4.3, 160 hp engine and 4:11 gears and auto, no AC. It had 70,000 mi. scratch and ding free body, dark blue metallic paint. We tuned it up, went through entire vehicle, changed all fluids, filters, lubed entire chassis and buffed out the paint. Of course he
proceeded to lower the truck and add a few upgrades. This truck was very quick due to the axel ratio. It was a work truck owned by a construction co. We paid $3500 for it in 1992. My son put 200,000 miles on this engine. Only repairs were alternator and starter. He sold and bought a used '94 lowered reg cab with 45,000 mi, 4.3 and 180 hp engine. This truck was far slower due to 3:08 gears. It was also trouble free to 200,000 miles again until he bought a new '99 Xtreme with 4.3 and 180 HP engine. Again that vehicle seemed slower than his '88. The Xtreme was upgraded with 17 in wheels and tires, lowered 2 more inches from factory lower. Additions of K and N, exhaust, chip upgrade to disable limiter. Vehicle was fast, but lacked tru punch. Again trouble free. He has since upgraded to leased 2001 Xtreme Blazer 2 dr.
My first S10 was a used 1987 Chevy Tahoe 4x4, ext cab with 2.8L 60 deg 125 hp V6. 3:73 gears, transfer case, skid plates, upgrade tires to UNIROYAL ATX LT235 X 75 15'S. Vehicle had 71,000 mi. I drove it to 144,000 mi. Only trouble was a broken plastic vacuum line. About $2.00. It was trouble free. Comsumer's report rated this truck UNACCEPTABLE, due to engine, electronics and Brake problems witch i never encountered. Only thing about this truck was that it was very gutless going uphill. Offroading was fun and exciting. I liked this truck so much i replaced it was a used 1991 Tahoe Blazer 4x4 4-door mini SUV. It was 39,000 trouble free miles, a lease turn in. It was maroon, had ABS, transfer case and a 160 HP 4.3 engine,
tow packkage, heavy duty radiator cooling. This vehicle was one of the worst vehicles i have ever owned. Problem area, brake pads every 18,000 mi, ABS system failure to the tune of $1700. I went to all auto parts stores to try and repair myself, they all said it was a dealer item, to go to dealer. This S10 also had numerous electrical problems, engine would smoke blue at start up due to defective valve guides. We finally traded this in a a leaased '99 Tracker 4x4, 4-dr 2.0L munchkin SUV. Which my wife drives exclusively. She love it. I don;t care for it much. I decided to try one more S10 purchase. A 2000 S10 Xtreme with 2.2L Vortec, 120 HP, 3:73 axel, ZQ8 suspension, 5 sp manual with short thro shifter, close ratio steering and beautiful body cladding. It was a reg cab in ONYX black. A great handling commuter vehicle with a 20 gas fule tank and erratic fuel guage that got 28-29 mpg at a steady 67 mph. I upgraded to K& N, a few mods to air box, catback exhaust. She could onloy do 93 mph, 0-60 in 12 secs but was a sweet looking vehicle. Trouble free to 20,000 mi then the Lemonaide factor set in, i mean i was at the mercy of the dealer. Severe stalling, at least 8 times, had to come to full stop before engine would start. Dealer could not find anything wrong, after 4 visists they told me to pick out another vehicle....it was the engine computer0
Great post! I am feeling about ten feet tall for having bought an older S-10 and hearing how reliable your older ones were.
Sorry about your bad luck with the newer ones.
I think the older body style is ten times sharper than the rounded off newer ones. What was the last year of the old body style? 94? Or was it '93?
Thanks for the post.
'93 was lost of the square stying since '82. I still love those old S10's. My Son just recently informed me the Alternator of his new Xtreme Blazer went out the 2nd day. Was replaced and all is ok so far. Try s10xtreme.com or xtreme.com i think. They have a very great web site and message board. I was no 111 on xtreme owners number. They have great data and info on all S10's from '82 to present as well as this forum. I came close to going with advance adapters package for small block V8 shoe in. JTR (Jaguars that run) in Livermore, Ca has a manual that will give you step by step photo instructions for putting Chevy small block V8 into any S10. Lots of goodies are out there.
Good luck with youyr S10. I feel if i staid with the '91 and the Xtreme i could have worked out the bugs, defects eventually. However when one is burned both financially and severe defects it hardens oneself against that product. My current 2000 3/4 ton C2500 has been trouble free for 34,990 miles as of this date and one year later. Even with heavy add-ons and mods. I still miss my Xtreme. Lots of fun while it ran trouble free for 20,000 mi.
Have a great weekend and holiday
PS I ordered the manuals from Helm's for $180.00 for my current truck. They are awesome, can take apart vehicle bolt by bolt with vived instructions. Best out there.0
Thanks for the info, Andy. I checked out the web site for s10extremes, and it looks interesting. I will get into it more in the next few days. I didn't see much for just plain old S-10's, but I didn't spend too much time there yet. I have it bookmarked.
Would appreciate any tips on the maintenance of my S-10. I have no experience with a vehicle with this many miles on it (currently 136,7XX).
I have always been a fanatic about oil changes, but other people have benefited by that, since I have always traded so often. I have taken care of new vehicles as if I were going to put 200,000 miles on them, but then I would trade them off before they reached 50K (often LONG before that).
Anyway, I was wondering if a guy needs to do something different or use a different type of oil for a high mileage vehicle.
I have heard about Valvoline Max Life oil, which is supposed to be designed specifically for high mileage engines. That just hype, or is there any real benefit to that stuff?
I have used Mobil 1 full synthetic in my last few vehicles, but I don't know if I should put my S-10 on that stuff. I have heard that synthetic oil does not keep the seals and gaskets as soft as regular oil does and can eventually cause leaks. Don't know if that is true or not.
Please jump in here with your opinions. I have 2200 miles on the truck since I bought it, and I plan on changing the oil at 3K. The dealer had just changed the oil the day that I bought the truck.
Anything other tips besides oil related stuff would be appreciated too.
Anybody care to pass on their opinion about what I should use as a limit for my highway speed, considering the high mileage on my S-10?
I have the 2.8 V6 with a five speed. I don't have a tach, so I don't know my RPMs at any given speed. I want the engine to last as long as possible, so I don't want to push it too hard. Right now, it doesn't use any oil, and I would like to keep it that way.
On a level stretch of road, will I be putting too much strain on the old engine at 65 or 70 MPH? It seems to run just fine at that range of speed. If I just drive without specifically trying to hold any particular speed, it seems to just naturally settle in somewhere between 65 and 70.
You guys that are new to trucks or to Chevy trucks in particular are going to enjoy your S-10s, especially if you live in an area that is not swimming in salt about six months out of the year. Hers's a few reasons why:
1. Trucks were first designed for, and still are aimed at commercial users and fleet managers. That means that they are designed, sold and maintained for their long service life. They typically have more parts available longer than a car, so we also enjoy the benefit. You'll be surprised to find out that even when your truck is 20-25 years old, body items like hoods, doors, fenders and bumpers will be readily available. If they were expensive or unreliable, a LOT of fleet managers would be going to Ford, Dodge (ugh!) or Toyota (ugh x 10).
2. While you won't usually find trucks in Motor Trend or Automobile magazine because of their latest gee-whiz high tech gadgets, you also won't have to worry about finding an exotic alternator, computer or brake system that "they only used one year and with certain engines and transmissions, and they haven't made in years." Common items like alternators, radiators, fuel injectors and other items often have the bugs worked out of them early in the course of their service life, and are relatively cheap to buy, new or rebuilt. My 2000 S-10 may not have rack and pinion steering, but I can lube all of the wear items on my truck's front end rather than waiting for one of those "sealed-for-life" grease fittings to fail and then have to replace an entire steering assembly.
As for maintenance on an older engine where you may not know its service history, here's a few tips:
1. Clean the fuel injectors using a product called 44K made by BG products. It is not some "miracle in a can" sold on late night TV, but it IS used by thousands of new-car dealers to keep their customers happy. If you can't find it locally, go to www.bgprod.com to find a local dealer or www.cambridgeauto.com, then go to the link for ryno products. They sell and ship 44K all over the country from that web site. While you are at it, change the fuel and air filters and the PCV valve.
2. At 100,000 miles, either remove the radiator to have it rodded out at a good radiator shop, or replace it. I know the manual doesn't mention this as a maintenance item, but it should. While it is out, replace the water pump and fan belt tensioner if they don't look as if they have ever been replaced. While you have the room to inspect it, check the harmonic balancer carefully to make sure the rubber isn't cracked.
3. Speaking of maintenance, after 100,000 miles, several items should be checked or replaced as a matter of preventive maintenance. These items include the shocks, front wheel bearings, brake wheel cylinders or calipers, all rubber fuel lines under the truck and ALL, and I mean, ALL vacuum lines. I usually just go to the parts store, buy about three feet of the three or four most common sizes of vacuum line, and replace each vacuum line ONE AT A TIME with the new hose that comes closest to matching it.
4. If you have turned over 100K miles, no one tells you this until they fail or your gas mileage goes down dramatically, but those spark plug wires probably saw their best days about 40,000 miles ago. While you are at it, replace the cap and rotor. Like the vacuum lines, do the spark plug wires ONE AT A TIME. As for plugs, I've heard good things about the AC Delco plugs made for older engines called RapidFire, or something like that. Otherwise, I would NOT recommend any exotic, split fire, double-gold, solid platinum/titanium, whatevers. I don't care how many of your buddies claim to get an extra 5 or 10 horsepower; the only thing most of those expensive plugs do is empty your wallet faster. Same thing about el-cheapo 89 cent specials. Just find out which AC-Delco plug came in your engine, and go with that in 90-99% of most situations.
By now you can tell I strongly believe in PREVENTIVE maintenance. Fact is, it is cheaper and easier to replace a water pump in my driveway in the shade on a cool engine than it is to do it by the side of the road in 90+ degree heat on a hot motor while traffic races by. As a result, I've never been stranded due to a mechanical problem in well over 20 years.
Good luck and enjoy your trucks.
Thanks a bunch, Joe. I enjoyed your post very much.
I have done some of the things you mentioned, or at least checked them.
It looks like the plug wires have already been replaced on my truck, so I think I'm in good shape there for a while.
The radiator was replaced during the rebuilding of my truck, since it was damaged in the accident that resulted in the truck being totalled.
I did have the cooling system flushed shortly after buying the truck. I thought that just cause the radiator had been replaced didn't mean there might not be some crud in the block. The radiator shop where I had the flush done reported that the stuff that came out of it didn't look bad at all.
I have replaced the PCV valve and the air filter.
I've had the serpentine belt checked and was told by a mechanic that I trust that it still has some time to go before it needs to be replaced.
We were going to check the front wheel bearings, but the grease looked real fresh, so it appears that they have recently been cleaned and repacked. I will need a brake job in the next few months, so I agreed to the mechanic's suggestion that we just wait until then to inspect the bearings.
I really hadn't given any thought to vacuum lines, so your tip on that was really useful. I'll get that done before too long.
Also, I will probably check on that fuel injector cleaner that you mentioned.
Thanks, again, Joe, and please respond to my question about how fast I should drive on the highway. I don't want to needlessly drive slow, but I SURE don't want to put too much stress on that little 2.8 either. It really seems to like to go 65 to 70, and I don't think it's under much strain at that kind of speed. I would like to hear other peoples' opinions on that.
Sure do love that little truck! I think I have a good one, and it was a steal at $2450 on the road price.
My mom had an 87 blazer with the 2.8. Blazer was great only had one problem with a hose when new but it was taken care of under a recall. Never was in the shop after that. She sold it May 2000. Truck was 13 years old had 136K on it. Only thing wrong was the air conditioning needed a new compressor. Guy didnt care.
She didnt drive it crazy and it lasted. It was tough to get the thing up to 70 but when it got there it was fine. I dont think it ever seen 75.
I have been the proud owner of a 1991 S-10 Blazer that currently has 148,000 miles on it. It is my daily driver since I don't like to get my 2000 3/4 ton Silverado dirty... but we won't go there.
The Blazer has been a great vehicle and the reason I bought the new PU. (there was a day when I said I would never own a chevy)
Anyway, my reason for posting is I have experienced a problem now for a while and I am hoping someone here can help. My Blazer has the 4.3 V6 with auto trans. The water pump started leaking and was changed out at about 120,000. The shop that did the work had to change the water pump two more times because the replacements also leaked... but they did it under warranty and it did not cost me any additional money. However ever since the first change out of the water pump the temp gage has always read hotter than the truck ever did before the change. Before the water pump was changed out the gage never read above 200. Now on a hot day the temp will almost go to the red line. I have taken the truck back to the shop that did the work and they flushed the system and changed out the thermostat (twice) but I still have this problem. I have not driven the truck much this summer due to it getting so hot in traffic. That is the other thing.. while driving at highway speed the thermostat will read below 200, but will rise when in stop-N-go traffic.
Also a little more history about the truck.. I bought it in 1992 with 25K on it and have always had the oil changed at 3000 miles. It now needs some minor cosmetic work but other than that it has been a great truck. Hope to get over 200,00 on it.
Thanks in advance for any advice you can give.0
Speed: Speed is relative and not much of a factor in a vehicle with an overdrive transmission or 5-speed. At 70 in 5th gear, the engine is probably turning about 2200-2400 RPM, depending on your rear axle ratio. However, it can put a load on other components. So, I would recommend driving it reasonably as long as everything else has checked out OK. About 70-75 shouldn't be a problem, as long as you know your brakes, steering and suspension are in first-class condition. You can actually do more damage by leaving the truck in 1st gear too long when driving away from a red light. That is because the engine could easily see 4500-5000 RPM if you "dog" it.
Heat: Welcome to Texas, NativeTX! Sounds like the shop has an air pocket trapped in your engine's coolant system. Check with the Chevy dealer or have the shop pull your truck's information up on Mitchell's or AllData to see if there is a proceedure to bleed any trapped air out of the cooling system. Otherwise, I would suspect they damaged the fan clutch when they replaced the first water pump. Have them check it; they should have looked at that already.
Good luck to all!
Thanks for your post. I was going to suggest some kind of fan problem, since you said it stays in the normal range at highway speeds. PAman beat me to it.
Sometime when the temp gage is showing high temperature, park the truck and leave it running. Then pop the hood and see if the fan is turning. Also, check the condition of the fan blades and the shroud. (AFTER you shut off the engine, he he).
Thanks to both of you for your posts.
Could be air in the system, but if the fan clutch does not do a full engage at idle in heat, I guarantee that 4.3 will heat up. On mine, it was quite obvious when the clutch locked in as the roar from the fan increased a lot. Also, check that the fan blades are not cracked. If so, they will flex and not move as much air. And you sure don't want to throw a blade at speed or you will see how fast hoses and belts can be removed!
I have always suspected the fan but was not sure. Too me it just does not seem to be truning as fast as it should, however, with my limited knowledge I was unsure. I will check it and see what happens.
Thanks again.0
mjbwrtr Posts: 172whats it cost to get hoses replaced and belts replaced on a 1993 chevy s-10 with 2.8 V6?
also it may need a clutch...are we talking $199 here or like $599?
thanks for the help guys...
mine has 109,000 miles on it and runs like new...i love my truck. 1993 s-10 Tahoe with five speed...one great little truck.
i am currently looking for a new ranger to replace it, because even though it gets 23 mpg in all-around use, the rangers get more like 26 and the new four cylinder has more power than my old V6.0
richcolo Posts: 81'83 S-10 4x4 Extended Cab 2.8 4 speed from 1986 to 1990. I loved it and kept it in beautiful condition. It was a great truck until one day, with 107,000 miles, the intake manifold gasket failed. The first symptom was the bang-bang-bang of a collapsed hydraulic lifter. I was only doing about 30 mph and stuffed in the clutch and shut it down within 10 seconds of the first bang. Towed it to a shop to have the lifters replaced. Mechanic calls with the bad news...half a gallon of coolant in the oil pan...all bearings shot. Wants to know "rebuild or replace?" I was a senior in college, driving school busses for a living and engaged to be married...the cost of either option might as well have been a million dollars, because I couldn't even come close. Had to sell it in "Does not run" condition and buy a rust-bucket '78 C-10. About three years later I saw a high school kid driving "my" truck...broke my heart. (I know it was mine because I put the toolbox, running boards, fender flares, bug deflector, stripes and alloy wheels on it myself...would be one hell of a coincidence if somebody else made exactly the same choices.) I'd probably still have it, if I'd been able to affoard a small-block swap at the time. I've still got the wife and the degree, and she still has the diamond that made me so broke at the time, so I guess I'm not doing too bad, but I may have to find an old S-10 to fix up just right for one of my sons....0
This discussion has been closed.


text:
6/15/2007 6:19pm, #11
Fantastic, look forward to hearing more. This is an excellent contribiution to consumer awareness in martial arts. :)You are a total Douchbag. Train more, post nevermore.
FickleFingerOfFate -08-21-2007 08:59 AM
just die already.Plasma - 08-20-2007 11:45 PM
Best MA website ever!!!!!: http://www.dogjudo.co.uk/
6/15/2007 7:48pm, #12
- Join Date
- Apr 2005
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WOW, what an amazing story. Thank you for bringing this out into the light."Sifu, I"m niether - I'm a fire dragon so don't **** with me!"
6/16/2007 12:33am, #13
Up until I left about 1.5 years ago, they still taught the full nelson escape assuming the fingers would be interlaced. I had similar experiences with failing to correctly interlace my fingers. Not with the "Grandmaster", of course.
6/16/2007 12:36am, #14
Three questions:
1. Is everyone pretty well convinced that this guy is genuine? I'm still feeling a little skeptical. Nothing personal. I can easily imagine this guy being a much better version of "Mantis" from the Comba-Tai thread--a guy who shows up to cheerlead and parrot what he thinks Bullshido wants to hear, then turns and tries to get everyone to turn with him.
2. I don't see how it's possible to hide your identity if those stories are true. Patenaude would have to know who you are instantly.
3. Not really a question--don't totally discount Patenaude's story about the street guy masturbating on the wooden dummy. It's not exactly the same thing, but I worked at Best Buy for a couple of years not long ago and had to work two day-after-Thanksgiving sales. These are crazy days when thousands of people go through the store and the lines stretch all the way around the entire big-box building. Both years I worked, we found human feces in places like furniture displays on at least two days during the after-Thanksgiving week. This was considered normal. Again, not the same thing, but if you can imagine walking into Best Buy on the busiest day of the year, dropping trou and defecating on the carpet in the middle of an aisle, surely you can contemplate masturbating on a Wing Chun practice floor.
Seriously, you guys, I thought my life would turn out so differently than this. It's Friday night and I'm taking a break from pulling up carpet in the living room to post this crap.
Where did my mom go wrong?
6/16/2007 12:40am, #15Originally Posted by Don Gwinn
then you'd know.
I don't particularly care for the whole 'impressionable youth getting taken advantage of' angle, and not sure if it rings true or not, but I *totally* buy the rest of the cult-y stuff. Been there, seen that.
The level of devotion is very high among the 'sifu' class. And to be honest, as soon as he started to let normal humans be sifus, he started to see them not be as devoted. It's almost like a self-fulfilling prophecy.
6/16/2007 1:30am, #16
6/16/2007 7:45am, #17
I'm pretty convinced he's legit. If you've had experience with these guys it's not hard to read something and tell if it's them or not. For example, when TKDBB sparred with a fanger, someone else had current fangers read it; at first they were skeptical it had even happened, but pretty shortly they were totally convinced. The details are too difficult to fake without having at least had a good deal of experience with FSD.
I agree about the stories being pretty specific for hiding one's identity though, and that did give me a little pause. I guess he's counting on sJP being really out of the loop or something; the more identifying stories involve only the two of them.
6/16/2007 8:50am, #18
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I'm pretty convinced this is legit. I've heard a number of these stories before. I'll see which ones I can dig up as already on the net.
Another version of the Homeless Story was posted on Bullshido already. The two stories are similar enough that it could be the same story from two different angles. Or they just had a lot of homeless people walking in to Catherine St. that got beat up by sJP.
Originally Posted by HAVOC
Last edited by Askari; 6/16/2007 8:56am at ."Sifu, I"m niether - I'm a fire dragon so don't **** with me!"
6/16/2007 10:30am, #19
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i think if the poster should log back so we may have some discussions with him...
i think the bum story are two separate incidents.
havoc's it was at the end of the class.
ghyslain's, it was while doing phon sau drills.
6/16/2007 11:08am, #20


text:
This week Bernhard, one of the Co-Founders of busuu.com was invited to hold a keynote speech at the conference "Future Learningscapes – a 21st century Challenge" organized by the University of Greenwich close to London.
Bernhard shared his experience of managing Europe´s leading online community for learning languages and gave his thoughts about how future learningscapes could look like.
According to his opinion, future learning will include a mix of learning activities (self-studying, peer-to-peer-learning, live teachers) and learning places (offline, online, mobile). Additionally, technology will be used in a much smarter way in order to improve the effectiveness of the learning progress of each student.
The conference was a great experience, a fantastically organized event and it was very good to see that the academic world more and more is aware of innovative learning tools like busuu.com, which could be used to improve the way students learn new languages within their academic studies.


text:
come with original accessories provided by the manufacturer (which may or may NOT include following):
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text:
Any thoughts whether I should do Merck or MedImmune PD1 or something else?
Just found out today I failed the taf/mek combo. So I'm trying to figure out the next treatment. At least I have choices. I'm thinking either merck or medimmune PD1 but my gut tells me there is something better I just haven't found it but I do feel it is something with PD1.
Merck EAP PD1 will be the 3mg/kg which they only reported results for all doses not this low dose. Otherwise seems to be no washout period or anything else bad about it that I could find. I can get this at Mayo where I'm already in their system. If I do this it disqualifies me for MedImmune PD1. NCT02083484
MedImmune PD1 would probably be the 10mg/kg. Has a 28 day washout period. Is phase 1 so is fairly unknown. I can get this at Sarah Cannon where I'm already in their system. Can do this and still qualify for Merck PD1. NCT02013804
NCT01753089 wdvax shows up as PD1 on search which looks interesting but is phase 1.
NCT01621490 BMS PD1 the folks at MD Anderson were not too eager for me to be in this when I asked them. Not sure why since it does allow ipi failures.
Not really seeing any other PD1 out there that I qualify for that has started.
The failing of the taf/mek combo was fairly minor according to the doctor's PA. One tumor grew about 50%. 2 new supraclavicular lymph nodes demonstrating increased FDG uptake. Everything else either stayed the same size or shrank by a tiny amount.
Re: Merck EAP PD1 or MedImmune PD1 - question?(4/29/2014 - 8:24am)
Artie, I can't tell you how impressed I am with how much you have learned and matured since you first started posting here. You are handling the emotional ups and downs of this disease with strength and grace and constantly trying to research the best treatment options available for melanoma. Considering how much work and frustration is involved in planning any treatments, especially clinical trials, and considering that you probably don't feel all that well or energetic most of the time, I think you're doing great.
I'm sorry that the BRAF/MEK was not 100% successful for you, but it's good that you had at least a partial response and your tumors are stable for now. BRAF/MEK is not usually a permanent cure, anyway. As you hoped, the extra time you gained from the BRAF/MEK allowed you to have at least 2 new treatment options-- Mercks' EAP or the Medimmune anti-PD1-- plus a couple of new clinical trials.
You seem to have a very good handle on your treatment options and some very excellent melanoma specialists advising you so there is nothing much I can add. The only thing you might want to think about is that the 2014 ASCO meetings will be held in Chicago starting May 30th. There might be some exciting new developments and helpful new data from melanoma clinical trials presented at the meetings. So if you are comfortable with a one-month "washout period" you might choose to wait a month to see what comes out at ASCO before making your final treatment decision.
In the meanwhile, has your tumor been tested for expression of the PD-1 ligand? I've heard that for people who are PDL-1 positive, the anti-PDL1 antibody works even better than does the anti-PD1 antibody. Just one other option for you to consider.
Re: Merck EAP PD1 or MedImmune PD1 - question?(4/29/2014 - 9:19am)
Pfizer may be trying to accelerate talks in part because the British drugmaker is scheduled to present promising data at the annual meeting of the American Society of Clinical Oncology, which begins May 30 in Chicago, according to one person familiar with the situation who asked not be named.
A deal would help Pfizer add early stage drugs in a field of cancer treatments that use the body's immune cells to recognize and attack tumors. In January, AstraZeneca announced an agreement with Immunocore Ltd. to develop new treatments that use immune cells, and it also has several of its own immune-based drugs being tested in multiple cancers.
Pfizer is back in the megamerger game.
The U.S. drugmaker has proposed buying AstraZeneca for $98.7 billion, in what would rank as the industry's biggest takeover, surpassing Pfizer's $64 billion purchase of Wyeth in 2009. AstraZeneca spurned the offer as too low, and Pfizer said it's considering its options.
If AstraZeneca agrees to a deal, it would create a company incorporated in Britain for tax purposes and run from the U.S.
The renewed approach comes amid a wave of mergers and acquisitions in the sector, pushing the value of deals to $153 billion this year, as the industry restructures amid health care spending cuts and competition from cheap generics.
"Society wants products faster, they want more products and they want value," Pfizer Chief Executive Ian Read said Monday. "Industry is responding to society's request for increased efficiencies and productivity."
AstraZeneca's stock climbed Monday above the offer price, gaining the most in more than two decades. It closed up 12 percent, at $77.01.
Pfizer, known for its Viagra drug, is headquartered in New York City.
For now, Pfizer is trying to draw AstraZeneca into talks. "We tried to get a mutual announcement to say we were in preliminary discussions," Read said. "AstraZeneca rebuffed that, which is why we were forced to make the announcement."
If Pfizer consummates the deal, it would be one of the biggest U.S. companies to go abroad. Read said that although he hadn't discussed that with the U.S. government, he was confident that it could get done.
Pfizer's January proposal "very significantly undervalued" AstraZeneca, the British company said in a statement. AstraZeneca also was concerned that Pfizer wanted to pay 70 percent of the price in shares, AstraZeneca said. The company concluded that, absent a specific and attractive proposal, it was not appropriate to engage in discussions with Pfizer.
"They're sellers, we're buyers," Read said. "Of course they're going to say it's undervalued."
Another key component of the deal is moving Pfizer outside the U.S. for tax purposes. A deal would allow Pfizer to use about $70 billion of cash it has built up overseas that would be subject to taxes if brought back to the U.S. and, because the combined company would be incorporated in Britain, would lead to a lower tax rate.
"I don't see why there's any conflict in what we're doing with U.S. policy," Read said on a conference call Monday.
Under British rules, Pfizer has until May 26 to make an offer or say it won't bid.
Pfizer may be trying to accelerate talks in part because the British drugmaker is scheduled to present promising data at the annual meeting of the American Society of Clinical Oncology, which begins May 30 in Chicago, according to one person familiar with the situation who asked not be named.
A deal would help Pfizer add early stage drugs in a field of cancer treatments that use the body's immune cells to recognize and attack tumors. In January, AstraZeneca announced an agreement with Immunocore Ltd. to develop new treatments that use immune cells, and it also has several of its own immune-based drugs being tested in multiple cancers.
Many of the largest drugmakers face patent expirations that are cutting billions of dollars from their revenues, forcing them to look for new therapies. Pfizer has reorganized its business over the past three years, shuttering some research projects and emphasizing others.
"The size of the deal testifies to the depth of the crisis Pfizer's in," said Ori Hershkovitz, a managing partner at Sphera Funds Management, which owns Pfizer shares. "They are trying to buy what they think is feasible, not necessarily what is most strategic."
Re: Merck EAP PD1 or MedImmune PD1 - question?(4/29/2014 - 8:41am)
I asked my doctors at MSKCC whether their was a difference in the effectiveness of af the anti PD-1 drugs now being tested... I am currently using the BMS product (3mg) with positive results.... My query was part of the never ending fishing expedition for the next line of treatment if/when this gives out The answer I got was that it will be some time before we can differentiate between these drugs. ( it seems relatively easy to establish a chemical blockade of the same PD1 interaction without a patent infringement-- and there appears to be a pile on in anti PD-1 marketplace --with the general assumption that a blockade is a blockade) My guess is there will be differences that emerge, if not in effectiveness then in duration, speed of reaction and side effects. For now, both appear to be good choices -- I think the Merck product is further along in the FDA testing process with unquestionably good results.... which may inspire confidence--I'm certainly impressed by the response rate. Medimmune is further out, so the data on effectiveness are probably scarce--- perhaps there are others on this site who can chime in with some study results. It is fortunate that you have an anti/PD-1 option - Though I believe with regard to direct comparison the jury not only out ---it has yet to hear the case.
Re: Merck EAP PD1 or MedImmune PD1 - question?(4/30/2014 - 12:55pm)
One thing I like about some of the smaller (or otherwise more accessible) cancer centers is being able to talk to clinical trial coordinators there on the phone and/or via email. MSK and MD Anderson won't do that in my experience.
One of the most useful things I've found about clinicaltrials.gov is the "contacat info" section of each trial listing -- phone#s and emails. The facility websites are also good if they have a "clinical trials" page/section. I was not willing to make a long trip to go in-person to MSK or MDA, in my case perhaps only to be told I didn't qualify for anything.
2 primaries; lung/brain mets in past; paratracheal lymph node currently; participating in Opdivo/Lirilumab trial
Re: Merck EAP PD1 or MedImmune PD1 - question?(4/29/2014 - 9:06am)
Artie, my quick 2 cents--there is a decent amount of data (trial results) behind Merck's product. The dosage they are using is probably what they anticipate will be the FDA-approved dosage. As far as I know (I may be wrong), MedImmune is just getting started with trials, i.e., little data. If it were me, I'd only go with MedImmune if it were being combined with another agent in the trial, which doesn't appear to be the case. As far as "something else", there was some talk on MIF within the past 2 weeks about the trial combining the BMS product (nivo) with anti-KIR (don't know much about it). I also noticed that Moffitt will be combining the BMS product with TIL, but that trial does not appear to be recruiting at this point (per the NCI site).
Re: Merck EAP PD1 or MedImmune PD1 - question?(4/29/2014 - 1:50pm)
I am on Merck pd1 (10mg) , and NED. Data presented my Merck indicates that 10 mg showed a greater response than 6 or 3mg. I am sorry that I do not have a link to the data but you should be able to find it. I think the reporting was presented by D. Ribas at UCLa.
Something to think about if merck eap is ONLY giving 3 mg out.
Good Luck..and keep us posted.
Re: Merck EAP PD1 or MedImmune PD1 - question?(4/29/2014 - 9:31pm)
I heard the same thing that killmel posted. Some are speculating the only reason Merck went with the 3mg for the EAP is simply due to availability of the drug at this point. Don't know if that's true or not.
You have a tough choice coming up but it's nice to at least have a choice. If I were in your shoes the one thing that would worry me about the MedImmune PD1 is that it's unproven. There was a PD1 trial done in the recent past (I can't remember which company it was) that had zero benefit. Totally sucked for the patients in the trial because it eliminated them from entering the BMS or Merck PD1 trial. You would think that the MedImmune would be as good or even better than BMS or Merck. Wonder if there is anyone you could contact at MedImmune to see if they have any argument as to why they think their drug maybe better than BMS or Merck.
Good luck,
Re: Merck EAP PD1 or MedImmune PD1 - question?(4/30/2014 - 12:15pm)
Can you please share the link where you found the dosage comparisons for MK-3475? I haven't been able to find any specifics. Also, the dosage isn't listed in the NIH trial info. How do you know its the lowest dose?
Thank you!
Re: Merck EAP PD1 or MedImmune PD1 - question?(5/1/2014 - 11:38am)
The full text of the 2013 ASCO report on Lambrolizumab (anti-PD1) can be found here: http://www.nejm.org/doi/full/10.1056/NEJMoa1305133#t=articleResults
A table that describes the details associated with Lambrolizuman can be found in the NEJM Supplement here: http://www.nejm.org/doi/suppl/10.1056/NEJMoa1305133/suppl_file/nejmoa1305133_appendix.pdf
It looks to me that, while the higher dose/frequency cohort had a higher response rate they also had more adverse events. The same thing happened with ipilumimab-- the 10 mg/kg dose worked better than the 3 mg/kg dose but with more side effects. Eventually, the FDA approved the 3 mg/kg dose.
While I understand the patients' frustration with the lower dose, from the company's point of view they are trying to accumulate data to support their FDA application and the FDA needs to see a good balance between efficacy with safety.
Re: Merck EAP PD1 or MedImmune PD1 - question?(5/1/2014 - 4:00pm)
Thank you both for the links!
Re: Merck EAP PD1 or MedImmune PD1 - question?(4/30/2014 - 1:36pm)
Artie, the current dose expansion cohorts for the nivo/liri trial are split among 5 different cancer types (they just added liver cancer I believe), they have only 16 slots for melanoma in the recently opened dose expansion cohort. I imagine those probably filled up really quickly, although I don' know for sure.
Going in person for an appointment when I found a promising trial with the recruiting door *about* to open, seemed to help. For a phase I trial with limited slots, maybe when the door is actually open, it's almost too late? I went in to Portland to get into the MEDI4736 trial, which at the last minute delayed the cohort I was trying to get into, and I ended up getting into the Nivo/KIR trial there instead.
From talking to clinical trial coordinators around 2 months ago, some things I learned, at least at the time are:
* Nivo + anti-LAG-3 (NCT01968109) -- new cohorts weren't open yet 2 months ago when I was calling.
* Nivo biomarker study -- I didn't qualify I think (per trial coordinator in Boston).
* Medimmune MEDI4736 anti-PDL1 + (Dab or Trametinib) -- wasn't open yet 2 months ago (per trial coordinators at 2 sites).
* The Dana Farber NCT01753089 dendritic cell activating scaffold -- the trial coordinator said they want to see the trial participant in person "every day" for months in Boston (if I recall correctly)
Another thing I learned at Portland is that BMS tends to concentrate their phase I immunotherapy trials at 5 locations -- Dana Farber, MSK, U Chicago who you talked to, Portland Providence, and Sidney Kimmelman in Maryland.
Hope this information is in some way helpful. Something like the Merck EAP, being an almost wide open wiondow, may be the most doable to get into, especially when travel is a big issue.-
- Kyle
2 primaries; lung/brain mets in past; paratracheal lymph node currently; participating in Opdivo/Lirilumab trial


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CEO: Doron Kempel
SimpliVity came out of stealth mode in August and released OmniCube, an appliance that integrates virtualization, networking, server and storage management.
The OmniCube platform simplifies deployment and management of virtual infrastructure to allow IT administrators to manage virtual machines.
One month later, Westborough, Mass.-based SimpliVity announced $25 million in funding from Kleiner Perkins Caufield & Byers, with existing investors Accel Partners and Charles River Ventures also participating in the funding round, bringing total funding to $43 million.