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Discover the beauty that is Buddha Mama. Delightful artisan-crafted statement jewelry.
...and your brains. Browse our bestselling earrings and find your perfect match.
Inspired by the natural world, sacred geometry and the beauty of Mother Earth...browse Noor's unique collection here
14K yellow, rose or white gold stacking ring with teardrop-shaped white topaz stone and white pave diamonds
Band Width: 0.2"
Taking inspiration from her background in Art History and worldly travels, Emily Faith launched her fine jewelry collection, EF Collection in 2010. Staying true to her personal aesthetic, Emily sets out to create delicate pieces that can be worn and enjoyed everyday with a chic, sexy and feminine feel. Focusing on the use of 14k golds subtly handset with diamonds and precious stones, EF Collection is a distinctive combination of understated glamour and simple elegance. Emily puts her own twist on architectural, geometric and classic forms, striking a beautiful balance between 'of the moment' relevance and timeless design. While each piece stands alone, they are enhanced when mixed, matched, layered and stacked.
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telephone : 949.675.2550
email : email@example.com


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- Inside Athletics
- Tickets
- Fan Zone
- Media Zone
- Social
- Shop
- E Fund
(Nov. 16, 2006) - ETSU softball head coach Andrea Mangrum announced Thursday that they will be holding its first-ever 2007 winter softball clinic in January. This clinic will be broken up into four sessions and will feature pitching, catching, and hitting drills, which will be taught by ETSU players and coaches. Please see additional information below regarding location, dates and times.
2007 Winter Clinic 4 sessions
You will not want to miss out on this position specific clinic designed to get you ready for your upcoming season!
25.00 per session or 2 sessions for 40.00
Location: The Edge (directions are on the brochure)
Session 1: January 20th 9:00-11:30 13 and under pitching and catching
Session 2: January 20th 12:30-3:00 13 and under hitting
Session 3: January 27th 9:00-11:30 14 and up pitching and catching
Session 4: January 27th 12:30-3:00 14 and up hitting
Please bring all gear including glove, bat, and catching gear if attending catching session. Do not wear cleats we will be on indoor turf. Also, please bring a sack lunch or make arrangements for lunch if you are attending both sessions.
Pitching and catching sessions will be limited to 30 participants and hitting sessions will be limited to 40 participants. Please note the registration deadlines on the brochure.
Sessions 3 and 4 will include closing remarks to help educate players and parents on the recruiting process.
Make all checks payable to ETSU Softball and contact Coach Mangrum for any other details.

subset: commoncrawl


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Follow along with our livestream provided by G4. Right Now: Nintendo's Press Conference.
10:14 That'll do it. We're about to go check out the Wii U. We'll let you know if it feels Wiierd.
10:12 "I want to end today by having you consider four platforms." I don't think I have enough money to even consider considering four platforms.
10:08 This thing is going to be great for any drawing games or create-a-players. You basically have a Wacom tablet right there, if it works correctly.
10:02 Batman: Arkham City will be on there. Same thing for Ghost Recon and Tekken.
9:57 Oh, here we go: Smash Bros. will work together on 3DS and the Wii U at the same time.
9:53 It'll have a browser and all that stuff. The best part, though, is how it interacts with the gameplay. You can flick objects from your controller's screen to the actual screen. It's a whole different kind of 3D.
9:50 Looks pretty impressive. And very confusing.
9:47 The new controller looks like a Nintendo 64 case mod. Almost exactly like this:
9:46 He just called it "utopian." Woof.
9:45 Here's the new console: Wii U. It's for by-yourself gaming. Which is what we all need, especially that Pokemon guy: More solitude.
9:42 There's a free Pokemon game on the DS online shop, so some guy in this arena yelled so loudly he may have literally lost his mind. I mean that. I can see his brain doing push-ups on the floor.
9:39 Luigi's Mansion. A montage. Too early for montages. Bring back the orchestra! Bring back the orchestra! Ole ole ole ole! Does the Wii have the FIFA franchise?
9:34 New Mario looks like a combination of the old-timey side scroller and bits of Mario 64. It comes out this holiday season.
9:32 Starfox 3D for the 3DS looks like a much prettier version of the old StarFox. Looks like the new Mario is up next.
9:30 Underwater levels in Mario Kart. And the ability to trick out your bike in very simple ways: Pick a base and some wheels. Pimp My Ride it ain't, but too complicated would be a disaster.
9:27 Man, Mario 3D and Luigi's Haunted Mansion 3D look gorgeous.
9:25 I seriously just had a Pavlovian response to the "Ready, Set, Go" sounds of Mario Kart. It made me want beer and college. They're showing off all their new 3D titles.
9:21 This orchestra thing is a really nice touch. Don't own a Wii, but Nintendo is doing a really good job on selling me tickets to the LA Philharmonic.
9:17 Four new Zelda games coming out, including one today called Link's Awakening on the EShop. Then Ocarina of Time 3D next week. Then a free DSWare game called Four Swords. Then Skyward Sword for the Wii for the holiday season. That is a lot of video games.
9:14 They're pretty much just messing around with the orchestra. Which is what I'd do, exactly.
9:10 Shigeru Miyamoto—who is the Jesus to Nintendo Power Magazine's Bible, if I remember my childhood correctly—is here to show off the 25th anniversary edition of Zelda.
9:08 This is really well-done. There's a chronology of the Zelda series up on the big screen with a live orchestra scoring it. Classy as all hell, Nintendo.
9:04 They're running Nintendo trivia on this big board, by the way. I've gotten, maybe, one right. It had to do with StarFox. I'm flying solo today, so I had to restrain myself from doing a StarFox impression, which would've made me seem like a full-on crazy.
TUESDAY 9:00 We're awaiting Nintendo to kick this thing off. We hear new Wii rumors. It'll probably be 3D. This thing better revolutionize cat videos and they better demonstrate that, or I don't know what I'm doing in a public space at 9 a.m.
8:00 Oh, that was MixMaster Mike. Jane's Addiction is here, apparently, and they're next. Not a bad way to end the evening. We'll be back tomorrow. – Ed.
7:00 They leave us with some ballet dancing to heavily mixed electronica. The ballet dancers are confused.
6:50 The WiFi here went down temporarily (a Sony Network outage! Huh!). Here's what was missed:
– The new Sony handheld is called Playstation Vita and it'll be $249 with just WiFi, $299 with 3G. The thing looks gorgeous. It's bordering on PS3-level graphics with their new Uncharted title.
– The crowd moaned pretty loudly when it heard the provider is AT&T.
– Streetfighter
– There'll be a new Playstation social network, but they did not provide any details at all. It's called Playstation Suite. It was pretty anticlimactic.
– And now they're playing the new Beastie Boys album. So life is pretty good. They're demoing everything.
6:09 Dust 514, a horrifyingly great looking timesuck of a massively multiplayer shooter. I will not buy this game, for I want to keep my job.
6:03 Sly Cooper, stylized like a Pixar movie, is coming in 2012. I don't remember what that is, but I'm going to pretend like I do.
5:59 Something something games that have already come out something something.
5:54 Every time somebody says, "Please put on your 3D Glasses," I'm just going to pretend like they're saying, "Please put on your pants." For example: "All right, everybody, it's time to put your pants back on. We're gonna shoot some skeletons with arrows."
5:52 Kobe just ran directly out of bounds on his second possession. Then LeBron hits a three. Kobe says, "That's not realistic at all." Quite a demo!
5:51 Kobe's here to test it out. I'm sure this is exactly where he wants to be during the NBA Finals.
5:50 Sorry. My nerd is showing.
5:49 They're upgrading passing, which really didn't need upgrading. Have these people heard of the R1 button?
5:47 NBA 2K12. Here's the only thing I can pretend to be an expert about.
5:45 Sony announces a Playstation branded, 24″ 3D TV for $499. Comes with and HDMI cable, 3D glasses (which they're selling individually for $70, which is crazy talk) and Resistance 3. Let's check and see if that's cheap.
5:39 Resistance 3 is next. It's like District 9 without the soul.
5:32 Apparently Drake is the MacGyver of falling long distances and getting hit by heavy things in cutscenes.
5:28 Sony's out here to show off Uncharted 3: I'm On a Boat. Wait, sorry, it's called Uncharted 3: Drake's Deception. But it is on a boat. And it does look awesome.
5:23 Sony apologizes for its network outage and all of those new hobbies you got when it was out. Thanks a lot, Jack Tretton! Now I'm into knitting!
5:17 Sony wants you to know they're really into their new Playstation phone, 3D, and dubstep.
5:14 I'm blogging in 3D now. Put on your glasses at home. You'll know it's working when your roommate walks in the room and calls you an idiot.
4:46 I just looked up "Weiner" in Hulu search right as the guy next to me was looking. He's foreign. He doesn't know why.
He has a very high opinion of me.
4:42 By the way, something here is going to be in 3D. We got those glasses.
4:40 Sony is doing this up right. There's about six open bars, free food from food trucks and Subway, I didn't sign up and the organizers truly didn't care, and I'm sitting next to people who smell considerably less like roast beef subs. Overall winner. I'm in a coliseum that has blued itself completely. There's foglights.
And WiFi! In a coliseum! This makes me feel much better about a future with The Sims Social in it.
Good lord. Why did I have to remember that?
3:15 Sony is next at 5 p.m. PDT.
3:10 Hey, we have our trusty live feed! Looks like Ghost Recon will be free from UbiSoft. That's pretty cool. Hopefully it will wreck havoc on the gaming industry, much like Carl's Jr. just did to that Australian guy's mood.
3:00 – Welp, UbiSoft just left about 60 percent of its RSVP'd attendees in the dust. That was lame. I was a casualty. So was some Australian guy who I went to Carl's Jr. afterwards because we were left about a mile away from the Convention Center. It's just one apology after another today for this guy. Carl's Jr. was my fault, at least.
1:30 Battlefield 3 is coming October 25th.
1:27 This game looks more entertaining than this Anthony Weiner/Andrew Breitbart press conference that I'm missing. Which is saying something, based on these Twitter accounts.
1:21 A nice jab at the Call of Duty franchise, citing how "absolutely free" Battlefield 3's multiplayer will be.
1:18 Battlefield 3 looks gorgeous. Just crazy gorgeous. It's the same sort of blow-you-away kind of moment Crysis looked like a few years ago.
1:11 Curt Schilling is here. He just said, "Talking about The Reckoning (his 38 Studios company created it) is every bit as exhilarating as talking about any of my three World Series rings." I'm a Red Sox fan. EA, you're just making me sad. Your next game demo better be a hyper-realistic virtual reality game called "Free Candy."
1:10 I do not want to live in this future.
1:08 The EA swagbag did not include a hammer to beat myself to death with. This is way too bad.
1:05 Oh God, "The Sims Social" just got announced. It's the Sims on Facebook. Everyone here groaned. Like, audibly.
1:03 Ray Lewis, Clay Matthews (with the Lombardi Trophy) and Madden 12 coverguy Peyton Hillis are here to yell loud, inspirational huddle sentences. They are large. There are no real details on how this game is going to be better, other than that they're improving on the "Controls on defense = Press triangle and pray until the play ends" from last year.
1:02 Wish granted.
12:57 Ole ole ole ole! Ole! O-showusMadden.
12:55 I'd tell you about FIFA 12, but soccer soccer soccer. You know. I love that game, but, of course, soccer.
12:54 Those were for SSX, the old school snowboarding game from PS2 fame. The trailer looks very good and classically stylized.
12:53 Damnit, that wasn't Febreze.
12:52 Here come the smoke machines.
12:50 Here's the EA presentation of the new Star Wars game, the only thing in the Microsoft presentation that didn't impress. It looks like WiiFit: Deathstar. Too much Kinect. I mean, have you smelled this theatre, EA? A shower is exercise for these people.
12:45 – The new feature in the Need For Speed series (this one's called The Run) is that you'll be on foot a lot of the time, as a character that looks a lot like Drake. You'll also presumably be stopped by the police and forced to tape a Sprite commercial, then you'll put out a concept album with Kings of Leon. (That whole last sentence is a guess.)
12:40 – Mass Effect 3 is coming out March 6, 2012. If this game is as good as these speakers are loud, you'll be deaf. I know that doesn't make any sense, but, seriously, it's louder than a KISS concert in a planetarium here. EA is making me feel like an old lady.
12:30 – I think video game companies are legally obligated to start their press conferences with Blur's "Song 2."
11:45 – Hey there, folks. Welcome to Hulu's coverage of Nerd Thanksgiving. We'll try not to be the racist uncle of this otherwise wonderful get-together of tech.
The EA presser is next. It's at 12:30. We'll have coverage on this here blog plus this livestream, provided by G4.
We just got back from the Microsoft presser. Yep, we're pretty impressed by the Halo 4 trailer (we were caught off guard by the timing, but it looks purdy), but we can't wait for voice controls in Mass Effect 3. You can swap out weapons by talking to your XBox and, in turn, 13-year-olds will stop singing us lullabies with racial slurs we've never heard before whenever the hell this technology takes effect. Cannot possibly be fast enough.
Also, Minecraft is coming exclusively (for consoles, at least) to the 360 solely to confuse parents nationwide. ("Honey, why are you playing the video for 'Money for Nothin" over and over again?")
Quick catch-up on the swag front: I was positive EA gave us cufflinks. Like, EA-branded cufflinks. This would've been good for, maybe, giving to a six-year-old, or filing off the inside to create tiny cookie cutters. Turns out it was a flash drive, thank God.
The Lombardi Trophy is outside. I'm going to ask these British guys next to me if they have any idea what it is.
Also, it smells like BO and chicken fingers everywhere. I probably should've anticipated that.
12:00 UPDATE ON THE BRITISH GUYS: Resounding no.
Our Live Streams Lounge continues coverage throughout the day; check back on Tuesday at 9 a.m. for Nintendo's press conference. We've posted the full schedule below.
|Monday, June 6
|Tuesday, June 7
|9:30 a.m.-11:00 a.m.: Microsoft
|9:00 a.m.-11:00 a.m.: Nintendo
|12:30 p.m.-2:00 p.m.: EA
|2:30 p.m.-4:00 p.m.: Ubisoft
|5:00 p.m.-6:30 p.m.: Sony
Additionally, Hulu will feature on-demand coverage from G4 and The Electric Playground on a page devoted to all things related to E3 2011. In the meantime, tune into our E3 Preview and E3 2011 Game Trailers playlists for the latest news.


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NetWellness is a global, community service providing quality, unbiased health information from our partners. NetWellness is commercial-free and does not accept advertising.
Tuesday, September 13, 2016
Did you know that, in the past 20 years, the death rate due to diabetes has increased by 45% and is the 7th leading cause of death, while the death rates due to cardiovascular disease, stroke, and cancer have decreased? The prevalence of diabetes in the American population has increased significantly to its rate of nearly 8%, with an additional 19% of the population having pre-diabetes, according to the Center for Disease Control's most current reports (June 2008).
Although the Diabetes Food Pyramid uses the former graphic of the USDA pyramid, it clearly conveys the message that persons with diabetes should include a variety of nutrient-dense, low fat foods in their diet. An individualized lifestyle plan is recommended, with an appropriate balance of food and physical activity for the management of diabetes and its complications, such as cardiovascular disease. Weight management is essential since type 2 diabetes, the most common form of diabetes, can be prevented or delayed through weight control.
Watch below to learn more about a healthy diet!
Yes, to maintain normal levels of blood glucose, it's important to eat at regular intervals. Since carbohydrates have the largest impact on blood glucose levels, carbohydrate-containing foods should be distributed throughout the day. Persons using insulin must coordinate their injections with food intake and adjust their dosages to the amount of carbohydrate consumed. Carbohydrate counting is a simple method of planning meals used by health care professionals. Based on your daily caloric needs, you are given a carbohydrate allowance for the day, divided into meals and snacks. You then select carbohydrate-rich foods, such as grains, fruits, starchy vegetables, and milk, in specific portions to fit your prescribed meal plan.
No, the recommendations for carbohydrate, protein, and fat for persons with diabetes are the same as those for all healthy Americans. In the past, persons with diabetes were told to completely avoid all sugary foods. Today, we know that the amount of carbohydrate is the most important influence on blood glucose levels. So, to control blood glucose while still having an occasional sweet, you can
Remember that a certified diabetes educator or registered dietitian can help you develop a tailored diet plan that meets your nutrient needs and your food preferences. For more information, visit the American Diabetes Association website.
This article originally appeared in Nutri-bytes (November 2007), a service of the NetWellness.org College of Nursing and was adapted for use on NetWellness with permission.
Last Reviewed: Nov 03, 2008
Professor of Nursing
College of Nursing
University of Cincinnati


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Did You Forget About These Jay-Z Verses Already?
We love Jay-Z. Arguably the greatest rapper alive, his talent is undeniable but even the greatest fall short sometimes. Justin Timberlake and Jay-Z's recent "Suit & Tie" wasn't the first time that Jigga dropped a verse that received a mixed response.
Click through the gallery to find out what other verses fell through the cracks


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2014 Mercedes-Benz E-Class Values
Select a 2014 Mercedes-Benz E-Class trim level
2014 model year changes
For 2014, Mercedes has made subtle style changes to the E-Class coupes and convertibles, with updates most notable in the front air intakes, LED headlights, and grille. Inside, the center stack has been redesigned, with the gear selector moved from the center console to the steering column. Later in the model year, the E350 with BlueTEC 3.0L diesel V6 will be replaced by the E250, which utilizes a 195-hp diesel 4-cylinder producing 369 ft-lb of torque.
Competitive comparison
A world-wide symbol of refinement, class and style; available wagon body style; fuel-sipping BlueTEC diesel engine available
Special features for 2014
The E-Class is Mercedes-Benz's mid-sized luxury car, competing with the BMW 5-series and the Audi A6. Being a true luxury car, the E-Class doesn't make many compromises. Performance, fuel efficiency and luxury are all high priorities for all E-Class trims. The E-Class Cabriolet is arguably one of the most luxurious and best-driving convertibles currently available. Mercedes-Benz build-quality and technical innovations provide unparalleled performance and comfort. A clever folding cloth top allows for 11 cubic feet of trunk space, even while folded. The E-Class wagon offers 68.9 cubic feet of cargo capacity. Featuring a powerful 302-horsepower V6, it offers excellent cargo transport in unequaled comfort. And the E63 AMG sedan and wagon are among the best-performing, most comfortable performance options for luxury midsize-class buyers.
Revised for 2014, the Mercedes-Benz E-Class is a luxury car available in sedan, coupe, soft-top convertible, and wagon trim levels. The E350 trims are powered by a 3.5-liter V6 engine (302 hp) while the E550 trims get an upgraded 4.6-liter V8 engine (402 hp). Sedans and coupes are RWD but the sedans are also available with 4MATIC AWD. For those drivers who prefer better fuel economy, Mercedes-Benz offers a choice between the E400 Hybrid or the new diesel E250 BlueTEC. All trims are available with a 7-speed automatic transmission enabling fuel mileage to fall within an EPA estimated range of 15 mpg city to 32 mpg highway, depending on model selection. For increased performance Mercedes-Benz offers the E63 AMG sedan/wagon, newly available with 4MATIC AWD. Features include navigation, premium sound, and hands-free phone capabilities. Safety comes in the form of 11-way airbag protection, blind-spot assist, anti-lock braking (ABS), electronic stability program, and active body control. The E-Class is backed by a 4-year/50,000-mile warranty.


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September 2001
"Endpoints" are actually just the key data items a trial is focused on. Or to put it another way, they are the data necessary to prove or disprove the trial's central hypothesis. They can be events in a person's life that serve as meaningful milestones for deciding if a treatment is effective. Some common endpoints are viral load, CD4 count, toxicity, quality of life, opportunistic infections (OIs), and death. If, at the end of a randomized trial, there is a difference between the tallies of endpoints in a treated group compared to an untreated group, it is attributed to the effect of the treatment.
In the early days of AIDS research, there were vehement and vocal protests against clinical trials that used death as a key data item. Loud sloganeering protested "killing for science," but in fact, while these trials may or may not have shortened or lengthened life, the outcomes were due to the disease and the drugs being tested -- not the choice of the endpoint. Using the "death endpoint" simply meant that dates of deaths were recorded, and that ample numbers of people were enrolled so that if, in fact, there were a difference in death rates, the trial would be able to measure that. Since deaths occur less frequently than, say, opportunistic infections (OIs), it takes more people in the trial to measure a meaningful difference.
In many ways an impact on mortality was, and remains, the most critical attribute of an anti-HIV medication. Sure, I personally would want to take a drug that reduced my viral load more. But this is only because earlier research has established that viral load is a good predictor of one's risk of death (it's also a partial surrogate marker, which is not exactly the same thing). The numbers of my viral load test have meaning only because they predict advancing disease and death. Otherwise, I really couldn't care less.
Concorde, the European trial of AZT in asymptomatic patients, by contrast, was much larger, and followed patients for three or more years, as opposed to the year and a half in the ACTG trials. Concorde revealed that there was indeed a "blip" of transient benefit at time points similar to the ACTG trials, but that by three years, long before most asymptomatic participants would have progressed to overt disease, the blip disappeared, and any benefit from AZT monotherapy was lost. The only remaining characteristic of those on the AZT arm was a much higher rate of toxicity. Of course, now we know that AZT resistance sets in fairly rapidly when it is used as monotherapy, but these trials took place long prior to resistance testing.
Critics of death as an endpoint often argue that for trials with early asymptomatic patients, death is likelier to occur due to common causes like automobile accidents, ODs, and homicide. This criticism was fed by the US Veteran's Administration (VA) study number 298: a study of AZT in asymptomatic people, conducted after the earlier AZT trials but before Concorde reported its results. The VA trial too showed little or no benefit from AZT monotherapy, but the drug's advocates worked hard to find a methodological flaw to blame this on, since Concorde had not yet spoiled the party. In particular, they pointed to the fact that a majority of the deaths were not "HIV associated." This criticism reflects a fundamental lack of understanding about the role of randomization. While randomization does not absolutely guarantee there will be exactly the same number of auto accidents in the AZT arm and the no-AZT arm, it does mean that the differences will be very small (if, in fact, AZT has no effect on risk of auto accident). But more importantly, random allocation of people between the treatment arms provides a sound basis for clarifying whether the difference in auto accidents was a matter of chance, or likely due to the drug. Skeptics used to point to suicide (which tragically has been all too common in AIDS trials) to criticize and ridicule the idea of using death as an endpoint. Now, with a greater appreciation of psychiatric side effects that has accompanied the growing use of Sustiva/Stocrin, differences in suicide rates related to treatment assignment is not as humorous or as irrelevant as once thought.
Imagine two treatments that perform virtually identically in their viral load effect at 48 weeks, yet have very different clinical performances over longer periods of time. A relatively tolerable regimen might allow years of good health, and a more toxic one could prevent HIV-related conditions, yet eventually poison you. The initial approval of the first protease inhibitors (PIs) offers some interesting insights. Despite those who claim that the age of clinical endpoint trials is over, the initial ritonavir study, conducted by William Cameron, and ACTG 320, which investigated indinavir, each showed dramatic reductions in both infections and deaths among patients taking PIs. Of course, now that there are several HAART regimens to choose from, and with OI rates having plunged even further from the dual-nucleoside days, similar trials would need to be far larger and longer if they were to be conducted today. An exception to this might be among salvage patients, who unfortunately are at immediate or near term risk of OI, which allows the clinical benefits of treatments to be more rapidly assessed.
There's another instructive lesson to be learned from the initial PI trials. Not one of the trials that led to FDA approval of the current PIs showed evidence of lipodystrophy or insulin resistance during the study period. These syndromes -- both with life threatening potential -- only began to appear after a year or more on treatment. So it's not enough to know that a treatment reduces your viral load. You also need to have some sense of whether the treatment itself is likely to kill you. Early on in the first days of protease euphoria, Keith Henry of Regions Hospital in Saint Paul wrote an article describing several previously healthy patients in their twenties who suffered alarming rises in lipids (cholesterol and triglycerides), and then suffered heart attacks after initiating protease therapy. These particular patients were relatively immunologically healthy. It would have been highly unusual if they had suffered an OI during that brief period. For them, at least, the treatment may have been worse than the disease. In the absence of clinical endpoint studies, we may never know how common an occurrence this is.
The issue is further muddied by the rapid approval of HIV drugs based on viral load changes over 48 weeks, as specified by the initial accelerated approval regulations. The situation is even worse today when drugs are approved based on 24 week data -- significantly short of half a year. The possibility of detecting slowly developing toxicities in such a short time is almost nil. After all, even 48 weeks was too short to observe lipodystrophy or insulin resistance in the initial PI trials. Also, 24 week data short-changes us on resistance information as well. It is quite possible for PI resistance to not fully develop within the first six months.
Obviously everyone wants new treatments to become available as soon as possible, but there's a crucial component of accelerated approval that has been neglected by the drug companies. Rapid approval based on virologic data was supposed to be only the first step to gaining full approval. Longer-term clinical follow up was supposed to continue after rapid approval. Drug company commitments to do post-marketing studies have for the most part been abandoned or done in a lackluster fashion. There is very little information published in the scientific literature that derives from longer-term post-market trials. Although post-market study is a formal obligation, written into the accelerated approval regulations, most companies simply ignore it, and the FDA unfortunately cannot, or will not force the issue.
Unfortunately, the public antipathy to including death as an endpoint contributed to a case of science being clouded by human desperation as well as business interests. People with AIDS needed new treatments as soon as possible, but if the FDA only agreed to review trials with mortality endpoints, then new drug approvals would be delayed. Neither the community nor the drug companies wanted that. Yet as we've seen, by foregoing death as an endpoint and by not following-up long-term there's an increased risk that a drug might slip through that actually shortens life.
Nowadays, of course, viral load is the most common endpoint in an antiretroviral drug trial -- although it can be used in several different ways. One way is to find the percentage of participants whose viral load is undetectable, or below the level of quantification (BLQ). This is a nice simple case of what's called a binary endpoint: something that can have only one of two possible values. The viral load is either detectable or not and that's all we know. Death is also a binary endpoint. We could still have the same censoring problems with viral load endpoints as with OI endpoints, but happily, people on treatment no longer die the way they did in the eighties. Nonetheless, censoring by death can be a significant source of bias.
One of the most common ways of dealing with censoring bias is to employ a "non-completer equals failure (NCF)" analysis. This is used when people in a trial are not available to have their viral load drawn, whether due to death, dropout or any other reason. The missing value is recorded as a "failure" -- in this case, detectable virus. Clearly, this also has its problems. An NCF analysis can possibly cause the drug's potency to appear understated. But that is preferable to believing a drug is effective when it is actually ineffective, or even killing people despite their having no detectable virus to measure. It also, some believe, adds a "reality factor." If many people stop taking one drug but not the other in a trial, or people on that drug just drop off, this suggests an underlying reason. The drug may be very toxic, difficult to take, or otherwise unattractive. So while NCF analysis may give a poorer estimate of the biological activity of a drug, many feel it can provide a preview of its effectiveness in the real world.
There are other ways to use viral load as an endpoint for a clinical trial. Using an average of viral load values for everyone in a trial can actually provide much more information than a simple binary (detectable/undetectable) result. But now there is a real problem about what to do with people who are in fact undetectable. If we decide to average the viral loads of all participants, what value do we set for those who are undetectable? There are a number of ways of dealing with this problem such as predicting what an undetectable value should be from the slope of past values or assuming that the undetectable value is at some point the middle of the undetectable range.
One drug company had its hide nailed to the wall by some sharp-eyed activists a few years ago. For the purposes of their trial, the company assumed that everyone who was undetectable was at the bottom of the range; they were assigned a viral load of 1. Viral load tests in those days were only able to detect virus levels above 500, so in this trial, the minute someone went undetectable, their statistical shenanigans made it seem like there had been a huge 2.7 log drop! "What a great drug!" crowed the company. "Not so fast!" said the activists. Despite this not-so-sly effort to cook the books, it's a real challenge figuring out how to deal with data and still come up with useful, scientifically valid answers.
But although death is still uncomfortably common in our community, it's nothing like it was in the eighties and early nineties, when gay men, injection drug users, and female sex partners of positive men were dying by the dozens every day. The last thing I would want this article to do is to flat out discourage someone from accessing treatment. Nonetheless, attitudes are rapidly changing, and many clinicians are wondering if putting people with high CD4 counts on these powerful drugs is a great idea. The Community Program for Clinical Research on AIDS (CPCRA)* is beginning a trial later this year to try and address some of those questions. The "SMART" trial will assemble one group of patients whose treatment is managed so as to keep viral load as low as possible at all times. Their endpoints will be compared to another group that will try to hold off treatment until their CD4 cell counts approach (but not too closely) dangerous levels. This is going to be a very large, very long-term trial, so definitive answers are years away. Meanwhile, as through so much of the epidemic, we are going to have to rely on the educated best guesses of our doctors and ourselves. Happily, even with treatment-associated illness, death rates are a small fraction of what they once were. As wonderful as this is in a human sense, it makes the science more difficult. "All cause mortality" is a very reasonable and useful candidate endpoint for clinical research. But with deaths on the decline, such studies will be very large and long. We can only hope that risk of iatrogenic (treatment caused) disease does not continue to increase with duration of exposure to antiretrovirals.
The protease inhibitors, non-nucleoside reverse transcriptase inhibitors, and the classic nucleosides gave us a mini-miracle. It would be hard to think of any disease where progress in treatment has been so swift and decisive. Unfortunately, everything comes with a price, and these very powerful drugs have substantial toxicities. It remains to be seen how many people can survive after five, ten, or fifteen years on these drugs. The challenge for antiretroviral clinical research, then as now, is to create endpoints that are meaningful for today. If future trials are to be relevant and provide us with the information we need to make safe, sound health choices, these tough questions about appropriate endpoints will have to be grappled with again and again.
* The author needs to disclose that he works for the Statistical and Data Management Center of the CPCRA, and is, in fact, on the SMART protocol team. However I am writing this piece as an individual, and nothing I say should be construed as an official CPCRA position.
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Tips for a safe holiday season
Posted Dec. 22, 2010
Holidays are great fun for kids, but there are often extra hazards for parents to look out for as well.
No one probably enjoys the holiday season more than children. Taking precautions to avoid sickness or accidents can help make sure their season is healthy and safe, too.
Avoid burns
UC Davis pediatrician Kevin Tracy says, "Unfortunately, burns are common injuries around the holidays, but you can take several steps to promote fire safety." Here are some tips:
- Check or install smoke detectors on each level of your home, preferably outside each bedroom.
- Use a sturdy fireplace screen to keep sparks inside the hearth.
- Use the fireplace only when you are at home, and extinguish the fire when you leave the house.
- Make sure all extension cords are in good condition. Never run them under a carpet.
Handle food safely
- Fully cook meats and poultry, and thoroughly wash raw vegetables and fruits. Bacteria are often present in raw foods.
- Wash your hands frequently, and make sure children do the same.
- Never put a spoon used to taste food back into the pot without washing it.
- Keep raw foods and cooked foods separate during preparation, and keep the utensil used to prepare them separate, too.
- Thaw meat in the refrigerator, not on the counter.
- Never leave meat at room temperature for more than two hours.
Remember that not all homes are childproof. Take a survey of the home you are visiting the moment you enter.
"Unsafe food handling is another cause of sickness during the holidays," Tracy says, "but most problems can be easily avoided by following a few guidelines."
Be mindful during and after gatherings
"Holiday parties can pose safety hazards for small children," Tracy says. Remember to:
- Clean up after your holiday party. A toddler can choke on leftover food or become dangerously ill on alcohol or tobacco.
- Leave the sitter the phone number of the home you are visiting in addition to numbers for police, fire, poison control center and your physician.
- Remember that not all homes are childproof. Take a survey of the home you are visiting the moment you enter.
For additional holiday safety tips, Tracy suggests that parents check the American Academy of Pediatrics Web site at www.aap.org.


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Amazon CEO Jeff Bezos Puts More Money Into Business Insider
Site Plans to Use Money to Hire More Staff, Finance U.K. Launch
Online news site Business Insider said it raised an additional $12 million in funding from investors including Amazon.com Inc. Chief Executive Jeff Bezos.
The site plans to use the money for growth efforts including hiring more journalists and photographers as well as to help finance a launch into the U.K., Business Insider Chief Executive Henry Blodget said. The money will also go to expanding the site's subscription research and advertising staff....


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With his team leading 22-17 in the fourth quarter of Super Bowl XLI, Indianapolis cornerback Kelvin Hayden returned an interception 56 yards for a game-sealing touchdown against the Bears. The play was particularly sweet for Hayden, a Chicago native who played at Hubbard High School and the University of Illinois.
Now on the Bears (he signed as a free agent in April), Hayden spoke with RedEye about winning a championship against his hometown team and the prospect of taking home another.
Kelvin Hayden: I go back to the AFC championship game—the Bears had the early game, we had the late game—and the game was on in the locker room while we were preparing. I was so caught up in watching their game just because, you know, being a kid from Chicago and how big the Bears are, it was just a matter of trying to stay focused and letting them handle their business. But to see them win it made it even more intense for me to want to win the AFC championship game. Then for it to actually happen—it was big.
My mom, she's a Bears fan. My whole family are Bears fans, and she was saying, oh, she would like to see the Bears do well, but she wants me to win. Stuff like that. And my family's like, they want the Bears to win and just want to see me do well. [Smiles.] And then to have a big play in the game against the hometown team, it gave me the bragging rights. That's all I wanted. It was good to see the Bears there, if I wasn't there. It was a big moment for me personally, something I'll never forget.
So what did your family say when you came home? You'd not only beaten the Bears, but YOU had beaten the Bears. That was it. That was the backbreaker.
Yeah, they were proud of me. [Laughs.] They said, you know, "Good to see that you are out there making plays, but it didn't have to be a play that put the game away." But everybody, we're just all out fun and games, love, and it's cool.
Let's flash forward six years. How are you feeling being here now?
I feel good. I feel good. This is another dream opportunity. I grew up wanting to play for the Bears. It's big for me, it's big for my family. We just want to enjoy the ride.
Do you have a Super Bowl on your mind?
Yes, of course! Every year everyone has the dream of playing in the Super Bowl, but here [pauses, looks around locker room] it's more a reality thing. It can be done. Some people just talk about it. We're talking about it, but we also believe. The coaches tell us every day that you're out there working to become Super Bowl champions. Anytime you think you don't want to do it, or physically you feel like you can't do it, just think of putting in that work toward one goal, and that's to win a Super Bowl.
All right, so it's February 2013, you guys have just won the Super Bowl. Where do you celebrate in Chicago?
I don't know. [Pauses.] I'm going to celebrate with my family. I'm kind of living the dream for them. Wherever they want to go is fine with me. It would be good for us to celebrate Chicago winning the Super Bowl together. Just a unity thing that we like to do. As a kid, everybody watched the Bears game at someone's house. It'd be fun for that to be reality.
Jack M Silverstein is a RedEye special contributor. Say hey @readjack.
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While Dolores grade school pupils know all about Mary and her lamb, they have their own version in a similar incident. The two Becher youngsters came to school Monday, followed by their pet William goat, which caused the teachers in the Washington building some concern and the pupils no little amusement before his goatship was persuaded that a school was no place for him. The Star will leave the matter of working the story into rhyme to some enterprising school boy or girl.
A theory that an early American civilization, the Arizona cliff dwellers, was wiped out by collision of the earth with the so-called Arizona meteor, or comet, some 650 years ago, was advanced recently by Ernest V. Sutton of South Pasadena, student of earlier Indian civilization of the southwest. Some 400 million tons of stratified rock were displaced by a tremendous collision, which created an oval shaped crater with walls 130 feet higher than the surrounding plain. These walls slope down 600 feet on the inside to a forty-acre floor. The crater extends 225 miles in all directions, near Holbrook, Arizona.
With my own eyes, said Sutton, I have seen mummified human beings sitting upright inside ruined buildings, as if something had suddenly sucked the life out of them.
In a tumble-down cliff house, near the great beehive dwelling known as Yucca house, there were three aged adults and a child. The adults sat with their backs to the wall, the child lay on the floor. I believe the cataclysm occurred during the day time, when hunters were on the ranges and all the younger women were in the fields.
A committee of responsible citizens has been formed to look after relief work in Montezuma County, to distribute funds received from the state and government for the purchase of necessary food and clothing for needy people in the country. The central committee is composed of the following men: E. S. Porter, G. O. Harrison, W. E. Farris, G. D. Taylor, S. C. Englehart, George Menefee and Harry French. Applications for relief may be made to local key men or to Secretary Miller. No cash will be given out, but orders will be given on merchants for necessities.
Jesse Robinson was down from Bear Creek Monday, buying supplies.
Mrs. Guy Harrison spent the day last Friday at the S. H. Phlegar home.
Herschel Snyder is helping out with the rush of mechanical work at the Dolores Motor Company.
C. W. Lilly returned to his duties at the local depot last Friday after enjoying a two-month vacation.
Mr. and Mrs. E. F. Burnett were out from Durango Sunday and took dinner at the Martin Rush home.
Dick Tucker returned home Tuesday from his trip to Salida, where he left his wife to undergo medical treatments.
Paul A. Shields has been teaching at Garrett Ridge High School this week as substitute for R. T. Periman, who is ill with cold or flu.
Workmen have been busy this week replacing the roof on the Blemear barn, which caved in under the weight of the deep snow last winter.
J. W. Gargan, Western Union relief operator, came in yesterday to take the place of Pat Stuart who has been ill for the past few days.
Paul McCormick and Miss Anita Winbourne went to Durango Thanksgiving day to attend a football game between Cortez and Durango.
H. G. Gaines has been busy this week building a room for his lumber yard office at the northeast corner of the former Rust lumber yard property.
Kenneth Tucker left Wednesday for Alamosa where he will join his wife who went over earlier in the week to spend Thanksgiving day with her parents.
Miss Virginia Leonard, of Ignacio, was an overnight guest at the J. B. Gelwick home Monday. Miss Leonard was en route to California for a visit with relatives.
Tom Mitchell, genial representative of Graham Paper Co, was working up trade here Tuesday. Business is picking up, Tom says, especially since the election.
Ben Millard was down from Stoner, buying supplies and visiting friends. Ben is planning to go to San Diego soon with his family to put in the winter.


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This post has been updated. Please see below for details.
The California Institute of the Arts launched its literary journal Black Clock in 2004 with pieces by some of the best writers of the moment: David Foster Wallace, Jonathan Lethem, Aimee Bender and Rick Moody. There were, of course, others -- that's what a good literary journal does, combine boldface literary names with new writers just finding their voices. One of those is CalArts MFA grad Grace Krilanovich, who was later named one of the National Book Foundation's 5 Under 35 for her debut novel "The Orange Eats Creeps."
But is the magazine's association with CalArts imperiled? The Los Angeles Review of Books seems to think so. "Speculation is brewing over whether the West Coast literary magazine Black Clock will remain at the California Institute of the Arts, the journal's original publisher, or move elsewhere," wrote Matthew Specktor on the LARB blog Monday.
"While the magazine's influence is greater than its circulation, it still seems crazy CalArts would let anyone else snap up such an enterprise," Specktor continues, "especially given the prominence Black Clock brings to the institute's MFA Writing Program."
Crazy, perhaps, but unfortunately familiar. Literary journals have been threatened repeatedly by universities in recent years, a target of recession-era budget cutting.
In 2009, Northwestern pulled the print plug on Triquarterly, the literary journal founded there in 1958. Triquarterly has tried, as an online magazine, to explore the possibilities of the form with new projects such as "cinepoems" and video essays.
Also reeling from 2009 belt-tightening was Middlebury College, which said it would no longer support its literary journal, the New England Review. Louisiana State University's Southern Review, founded by Robert Penn Warren and Cleanth Brooks, faced extinction at just about the same time.
Both the Southern Review and the New England Review survived, however, after voices were raised in support. Both found new ways to approach budgets and fundraising. Both still are associated with their respective universities, and both still appear in print.
What does the future hold for Black Clock? Specktor writes: "Maybe this is all just the usual palace intrigue, real or imaginary, that goes with any sort of high-level personnel changes such as those that CalArts reportedly has undergone this past year. Time will tell."
Update 1/30 12pm: Matthew Specktor's name was missepelled as "Spector" in an earlier version of this post.
200 Years of Jane Austen's Pride and Prejudice
Fate of Timbuktu manuscripts uncertain as library burns
Caldecott, Newbery Medals awarded by American Library Assn.


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Why small animal veterinarians should care about farm animals
Growing up in suburban Long Island, New York, I had no knowledge or understanding of how animals on farms were cared for or where my food came from. I first became aware of how food animals were treated in the book Animal Liberation by Peter Singer,1 which I read long after graduation from veterinary school.
In the United States, we raise and kill approximately 9 billion animals per year on farms far removed from the clean offices where we practice as small animal veterinarians. Singer and others2 have described how over the past 60 years animal agriculture has shifted from a culture of husbandry, in which the farmer was a steward of his or her small herd living on pasture and felt a responsibility to ensure the animals' welfare, to its present state of industrialization, in which animals are bred to be increasingly large, processed in higher numbers and confined in smaller spaces. We have moved from an era in which farmers were the animal's caretaker to one in which we have sacrificed virtually any commitment to farm animal well-being.
According to the American Veterinary Medical Association (AVMA), approximately 77 percent of veterinarians in 2012 practiced exclusively or part-time on small animals.3 Many of these small animal veterinarians have adopted dogs or cats that others relinquished and are helping to improve the lives of their future patients by volunteering at spay-neuter clinics and contributing time and discounts to local rescues and other humane organizations. Yet our actions don't seem to extend to animals we don't see or interact with—animals that desperately need our assistance.The case for farm animals
According to the AVMA, there are approximately 70 million pet dogs and 74 million pet cats in the United States.4 Comparatively, the number of animals slaughtered in the United States in 2011 was more than 9 billion, as follows:
> 8.7 billion chickens
> 246 million turkeys
> 110 million pigs.5
For those less inclined to follow decimal points, consider this: The number of turkeys slaughtered in one year far surpasses the number of pet dogs and cats combined, and the number of farm animals killed in one year is more than 60 times the number of pet dogs and cats combined. If for no other reason than the sheer magnitude of these numbers, the plight of farm animals warrants our concern. Here are a few considerations:
Housing and confinement of pigs. More than three-quarters of breeding pigs (approximately 6 million) are confined in gestation crates—metal cages approximately 2 feet wide by 7 feet long. Sows are unable to turn around in this cramped space and live in these crates for four months without respite. A few weeks after nursing is completed, she is impregnated and transferred back to the gestation crate. A breeding pig thus spends nearly every moment of her life confined to a degree of virtual immobilization.6
Housing and confinement of chickens. In the United States, approximately 95 percent of egg-producing chickens (estimated at 280 million) are confined inside battery cages.7 Standing practice confines eight hens in a cage so that each bird has less space than a letter-sized piece of paper on which to stand.8 Thus confined, hens are unable to manifest normal behaviors such as nesting and perching.
Cognitive abilities of chickens. Observation of chickens in their natural environment reveal them to be capable of social attachments and preferences and to have cognitive skills rivaling those of mammals.10
Cognitive abilities of pigs. Pigs are highly intelligent, curious animals. According to a recent study in the journal Animal Cognition, "Animal welfare scientists ... share the opinion that pigs have considerable cognitive abilities. The public's perception of the intelligence of an animal influences the importance attached to its welfare, and many consumers consider farming practices that result in poor animal welfare to be unacceptable."11


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Bucs fire special teams coordinator LigasheskyPublished: January 30th, 2013
By Bucs Beat Feed
The Bucs have fired special teams coordinator Bob Ligashesky after one season.
Tampa Bay was 30th in the NFL in kickoff return yardage last season with a 20.3 yard average. The Bucs were tied for 19th in the league in punt returns with a 9.0 yard average.
Ligashesky's firing is part of a shake up of coach Greg Schiano's staff after only one season. Defensive backs coach Ron Cooper was given permission to take a similar job with the University of South Florida, where he also will serve as associate head coach. Quarterbacks coach Ron Turner left to take the head coaching job at Florida International University and was replaced by Cardinals assistant John McNulty, a long-time assistant for Schiano at Rutgers.


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The LP2980-N is a 50-mA, fixed-output voltage regulator designed specifically to meet the
requirements of battery-powered applications.
Using an optimized VIP (Vertically Integrated PNP) process, the LP2980-N delivers
unequaled performance in all specifications critical to battery-powered designs:
Dropout voltage: Typically 120 mV at 50-mA load, and 7 mV at 1-mA load.
Ground pin current: Typically 375 μA at 50-mA load, and 80 μA at 1-mA load.
Sleep mode: Less than 1-μA quiescent current when ON/OFF pin is
pulled to less than 0.18 V.
Minimum part count: Requires only a 1-μF capacitor on the regulator output.
Precision output: Initial output voltage tolerance of ±0.5% (A grade).
5-V, 4.7-V, 3.3-V, 3-V, and 2.5-V versions available as standard products.


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26 U.S. Code Subchapter G - Donor Advised Funds
Pub. L. 109–280, title XII, § 1231(a), Aug. 17, 2006, 120 Stat. 1094, which directed the addition of subchapter G at the end of chapter 42, without specifying the act to be amended, was executed by adding subchapter G at the end of chapter 42 of this title, which consists of the Internal Revenue Code of 1986, to reflect the probable intent of Congress.
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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Makeup and Hair From 2011 Paris Haute Couture Week 2011-01-27 10:45:09
See the Looks From Paris Haute Couture Week
See the Looks From Paris Haute Couture Week
Paris Haute Couture Week just ended, and it feels like the shows went by incredibly quickly this season. We saw some truly avant-garde looks this year from the likes of auteurs like John Galliano, and some absolutely beautiful work from relative newcomers like Stéphane Rolland. If you haven't gotten to see photos from all the shows, I've grabbed the best look from each, distilled the most important features of the look, and put them all in a handy 20-image slideshow. So, ready to get up to speed on all things couture in a flash?


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Handbook to Practical Disaster Preparedness for the Family, 3rd Edition
Right out of the gate let me tell you what the book is NOT. It is not a book about fighting off hordes of flesh-eating zombies, should they ever rise from the grave. Nor will it describe how to survive a shipwreck by feasting on coconuts and roasted iguana. Finally, it is not intended to help you survive our planet being sucked into the cosmic fireball affectionately known as our Sun. If you wish to prepare for those types of events, I respectfully suggest that you continue your search for a more suitable text.
This book IS designed to help your family prepare for more commonplace, yet still equally deadly disasters. The list is long and varied, and includes hurricanes, tornados, terrorist attacks, earthquakes, pandemics, financial collapse, floods, widespread blackouts, food shortages, airborne contamination, radiation exposure, and much more.
The Brand New 3rd Edition is clear and easy to read with more than a hundred photos, illustrations, and worksheets. What makes this book different is that it focuses on practical steps that you and your family can take to become better prepared. At the end of your efforts, you will be rewarded with knowing that your family is far better prepared to handle real-world challenges.
Recent Expert Reviews
A great introduction to disaster preparedness in a single volume, both scholarly and easy to read! Provides practical information for families seeking to organize their preparedness efforts. — James Talmage Stevens, Making the Best of Basics
An easy to read handbook packed full of very helpful information to cover any emergency one might encounter. — Marg Pollon, Founding Director of Bridges of Love Ministry Society
This book is an incredible compendium of knowledge in the area of disaster preparedness. In spite of the many pages, it is never daunting or overpowering but rather written with a comfortable conversational tone. — Kerry Lewis, Master Anjing Banfa
Families want and need actionable practical plans when disaster strikes and the Handbook to Practical Disaster Preparedness for the Family has it all in one volume! This is one of those books that'll be in high demand then, that you'll be reluctant to ever loan out. — Shane Connor, ki4u.com
The Handbook to Practical Disaster Preparedness for the Family, by Arthur T. Bradley, Ph.D. is absolutely fabulous. Whether you're a novice just starting out, a seasoned "prepper" or a die-hard survivalist, this is one book that you should add to your must read list. In fact, I bet most of you will be adding this book to your libraries and go-bags or BOB's. — Keith Erwood, disasterpreparednessblog.com
I wrote this handbook for my own family, but I would be honored to share it with yours. If you are not fully satisfied with the Handbook to Practical Disaster Preparedness for the Family, send it back, and I'll refund your money, no questions asked.


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Movie Description(Click Here To Hide)
Based on Arthur Kopit's book for the 1982 Tony Award-winning musical, "Nine" features an all-star cast of Nicole Kidman, Daniel Day-Lewis, Judi Dench, Marion Cotillard, Penélope Cruz, Sophia Loren, and Kate Hudson. The story centers on Guido Contini (Day-Lewis), a gifted Italian filmmaker who develops writer's block at the age of 50. Looking for some help, he calls on all the women in his life from both the past and present.
Nine Reviews
2012-10-31 16:46
Movie Review: "Nine"
-- Rating: PG-13 (smoking, sexual content)
Length: 118 minutes
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Celebrating America's Founding, Founding Documents, Traditions, and Treasures
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Subscriber Profile Page
Blog Posts
Index of What IS Right With America Blog Posts
Email Blog Signup!
Susan's Books, Videos, & More
Articles by Susan C. Rempel, Ph.D.
Benjamin Franklin's Wise Words For Certain Elected Officials
Say What? How the Battle Between Individual Liberty and Societal Norms Impacts You This Christmas Season
They Spoke as One…Now it is Our Turn
Thoughts on Executive Proclamations
What do Christmas Trees, Elephants, and Tanning Salons Have in Common?
What Does Your Child Know About Thomas Jefferson?
When Did You, or Your Child, Last Read the Constitution?
Where's the Party? Is Thanksgiving Fading From the Public School Curriculum?
Work and Save
Assuring Our Safety Or An Invitation for Tyranny?
Whispering Away Our Liberty
The Supreme Court as an "unelected group of people"?
Books by Susan C. Rempel, Ph.D.
Everyone's Guide to the Constitution
In The Bill of Rights, The Framers Gave To Me
Dr. Rempel's Favorite Conservative Products, Images, & Posts
Pins created by Dr. Susan Rempel
Videos by Susan C. Rempel, Ph.D
A Sampling of Dr. Susan Rempel's Favorite Quotes
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13 Colonies
British Proclamations and Documents Regarding the Colonies
A Proclamation, by The King, for Suppressing Rebellion and Sedition
Lord Dunmore's Proclamation Freeing Slaves to Fight Against Colonists (November 7, 1775)
New York Restraining Act 1767
Royal Proclamation of October 7, 1763
Thomas Gage's Proclamation of June 12, 1775
King George III's October 27, 1775 Address to the Houses of Parliment
British Taxation and Regulations Without Colonial Representation in Parliament
Currency Act of 1764
Intolerable Acts
Administration of Justice Act (1774)
Boston Port Act (1774)
Massachusetts Government Act (1774)
Quartering Act of 1774
The Quebec Act, 1774
Molasses Act (1733)
Quartering Act (1765)
Tea Act (1773)
Paper Bills of Credit, American Colonies Act 1750
Sugar Act / American Revenue Act or the American Duties Act (1763)
Correspondence from Thomas Cushing to Jasper Mauduit Regarding Passage of the Sugar Act
John Robinson and The Polly
Stamp Act of 1765
Declaratory Act 1766
Currency Act of 1773
Colonial Charters and Early Documents
Charter for the Province of Pennsylvania
Charter for the Province of Pennsylvania
Charter of (North) Carolina
Charter of Connecticut – Fundamental Orders
Charter of Delaware
Charter of Georgia
Charter of Maryland
Charter of Privileges Granted by William Penn, Esq. to the Inhabitants of Pennsylvania and Territories
Charter of Rhode Island and Providence Plantations
Charter of West New Jersey
Frame of Government of Pennsylvania
Grant of the Province of Maine
Penn's Charter of Libertie
Privileges and Prerogatives Granted by Their Catholic Majesties to Christopher Columbus (1492)
Purchase of the Island of Manhattan by the Dutch
The Act of Surrender of the Great Charter of New England to His Majesty
The Charter of Massachusetts Bay
The Charter of New England
Mayflower Compact
Charter of Virginia, 1611
Maynesborough Charter
Colonial Reaction to Imposed Taxes and Regulations
Boston Massacre
A Short Narrative of the Horrid Massacre in Boston.
Boston Gazette March 12, 1770
Deposition of Captain Thomas Preston
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Fifth of March Oration by James Lovell
Fifth of March Oration by John Hancock
Fifth of March Oration by Joseph Warren (1772)
Fifth of March Oration by Joseph Warren (1775)
Innocent blood crying to God from the streets of Boston
Report of the Committee of the Town of Boston
Boston Tea Party
Braintree Instructions
Declaration of Rights and Grievances Passed by the Stamp Act Congress
Oration on the Beauties of Liberty
The Rights of the British Colonies Asserted and Proved
Fairfax Resolves (1774)
Fincastle Resolutions
Committees of Correspondence
Circular Letter of the Boston Committee of Correspondence
Virginia Resolutions Establishing A Committee of Correspondence
Documents Written Before 1776 Regarding Uniting the Colonies
Albany Plan of Union (1754)
Benjamin Franklin's Sketch of Articles of Confederation
Halifax Resolves
Mecklenburg Resolves
Notable Speeches, Pamphlets, and Books by the Founders
Preamble and Resolution of the Fifth Virginia Convention (May 15, 1776)
Tryon Resolves
Sheffield Resolves 1773
Concerning non-Importation and a General Convention (1774)
Suffolk Resolves
Declaration of the Association of the Freemen of Maryland
Political Cartoons of the Founding Period
Support for the Colonies in British Parliament
Coercive Measures in America
Speech against the Stamp Act
Continental Congress
First Continental Congress
Address to the People of Great Britain by the First Continental Congress (1774)
Continental Association
Declaration and Resolves of the First Continental Congress (1774)
Prayer Delivered at the Opening of the Continental Congress
Letter to the Inhabitants of the Province of Quebec
Memorial to the Inhabitants of the British Colonies
Petition to the King (1774)
Second Continental Congress
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#2064 (no title)
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Another JMU Alumnus Makes Live Voting Round in Walmart Contest
Chad Hensley graduated from JMU in 2002 with a BBA in Computer Information Systems. After 7 years working as a software consultant, Chad started his own consulting business, Tall Shadows LLC, in 2009 and eventually launched HuntersClub.com and developed WISE trail camera software.
WISE is deer scouting and management software for the computer that syncs trail camera images with weather data and the moon phase. This allows hunters to pattern deer activity, ultimately making them more successful in the field. WISE will even suggest to the hunter where to hunt based on past data.
Walmart emailed Chad in July asking him to enter WISE into their "Get it on the Shelf" contest. It passed the audition round and made it into the live voting round, which started August 6th and ends September 2nd. In the live voting round, the public votes on products, and whichever one get the most votes has the opportunity to be sold online at walmart.com.
Chad came up with the idea while sitting in his tree stand one October morning. He had always wondered why deer and other animals are so active one day, and then the next day, there could be little to no activity. His theory was that it had to be weather, but that it was not discernible to humans. By combining weather data from over 20,000 weather stations across the United States with the time stamp on each image taken by a trail camera, Chad was able to start creating predictable patterns for deer based on wind speed, wind direction and temperature.
Chad attributes some of his success to his education from JMU.
"My CIS classes set the foundation for my software consulting career. With programming I was able to take something I was really good at and pursue my passion. Beyond that, business concepts come easy, and that foundation I developed in my core COB classes. I remember helping my COB 487 team to a dominating win in the "Shoe Game", and I carried those techniques to the real world. My Facebook page currently has over 63,000 fans, and a lot of that was strategic marketing and building relationships with other outdoor companies."
Help support Chad's product for an opportunity to get on Walmart's shelf. You can vote for WISE here: https://bitly.com/vote-for-WISE vote. Everyone can vote once a day, every day until September 2nd.
For more information on WISE, visit http://wise.huntersclub.com and like the HuntersClub.com fan page here http://fb.com/EatSleepHunt .
Published: Friday, August 30, 2013
Last Updated: Wednesday, June 8, 2016


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Did you know....... October 1st is Scrap-Friendzy's 5th Birthday!!!
That's right.... 5 years of scrappiness! 5 years of inspiration!
5 years of friendships!
We are so excited! It's time to celebrate and everyone is invited!!
Join us the entire month of October for our
There will be tons of challenges, games, prizes & fun! You don't want to miss it!
And as a special treat....
We've asked some of our DT members from the past 5 years to come back and challenge us!!
It's going to be a blast!
Join us in the forum in the BIRTHDAY BASH section on Monday, October 1st!!


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NEW YORK (AP) — Stocks are slightly lower in early trading on Wall Street as the pace of corporate earnings reports picks up.
The Dow Jones industrial average was down 30 points, or 0.2 percent, at 16,407 in the first few minutes of trading Monday.
The Standard & Poor's 500 index was down two points, or 0.1 percent, at 1,840. The Nasdaq composite was down three points, or 0.1 percent, at 4,170.
Lululemon, the high-end yoga apparel maker, slumped 15 percent after saying sales have dropped off in January and that its fourth-quarter results will be lower than analysts had expected.
Beam, the maker of Jim Beam, Maker's Mark and other liquors, jumped 24 after saying it had agreed to be acquired by Japan's Suntory for about $14 billion.


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I'm using a Bible program to read the Bible in greek. It is the e-sword:
The greek text has some letters showing what kind of word is there... Like V-PPI-3S. I imagine that this means that the word is a verb in present passiv indicative, third person singular... I want to know if there is a table of the meanings of all these codes...
But the main question is about Heb 9:23. There is a verb, katharizesthai, that is translated as "should be purified" in the King James, but the verb is an infinitive present verb. I tried to find more details about the infinitive, but I didn't find anything that could explain this translation.
Anybody here can help me?


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NEW YORK (AP) — Stock futures bounced back Friday from consecutive days of significant declines, with more evidence of a rebounding U.S. housing market.
Developers ramped up construction in July, partly reversing a notable decline in June.
Dow Jones industrial futures rose 14 points to 15,084. The broader S&P futures added 3 points to reach 1,658.70. Nasdaq futures tacked on 7.25 points to 3,078.25.
Last month, builders initiated work on houses and apartments at a seasonally adjusted annual rate of 896,000.
While that's slightly below forecasts, it's still up 6 percent from June. Construction peaked in March at slightly more than a million.
Applications for permits used for future home construction also rose, though mostly because of volatile apartment construction. Permits for single-family homes actually fell 2 percent.
U.S. markets have been hammered this week by disconcerting reports from retailers and it's unlikely that a stock rally Friday will put major indexes into positive territory for the week, or for the month to date.
On Thursday, Wal-Mart and Nordstrom pulled back on their expectations for the year, a day after Macy's did the same.
Gloomy numbers from the country's biggest names in retail has cast a pall over markets as the sector heads into the meat of its earnings season.
J.C. Penney, Target, the Gap, Home Depot, Best Buy, Barnes & Noble, Saks, Staples and Sears all report quarterly earnings next week.
How retailers are doing can telegraph the mood of the American consumer, and that is closely watched by economists because consumer spending drives about 70 percent of all economic activity in the country.
Americans may ramp up spending in the next few weeks, but a dawdling entry into the crucial back-to-school shopping season clearly darkened the mood on Wall Street this week.
The Dow Jones and the S&P are down about 2 percent. The tech-heavy Nasdaq is down only 1.5 percent, thanks in part to a surge in the price for shares of Apple.
But the tech sector has not gone unscathed either this week.
Cisco, the computer networking company, said Wednesday that it was cutting about 4,000 jobs and its CEO, John Chambers, called the global economy "challenging and inconsistent."


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New research from Frost & Sullivan has found a flourishing contact center applications market in Latin America, driven by the need to ensure higher quality customer interactions, an investment-friendly atmosphere, and the rapid development of new markets in the Andean region.
The Frost & Sullivan report, "Overview on the Latin American Contact Center Applications Markets," has found that the market earned revenue of more than $407.1 million in 2011 and is expected to reach $757.9 million in 2018, at a compound annual growth rate of 9.3 percent. The Latin American contact center applications market in the Andean and Southern Cone regions is expected to grow at 10.3 percent and 9.8 percent respectively through 2018. Brazil will be the regional revenue leader with a 51.6 percent share of the market.
"Market expansion in Latin America will lead to substantial contact center application development to ensure efficient customer interaction," said Frost & Sullivan Research Analyst Martin Ramirez. "Proactive tools will also be in high demand as contact centers will be focusing on business intelligence in order to implement a personalized approach to customer relationships."
Among some of the other findings are the following:
"However, demand for new and effective solutions may lead to increased interaction through social media," concluded Ramirez. "As the large-center segment reaches maturity, vendors must come up with new strategies to penetrate the small and medium business market and stay competitive."


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Enkitec folks have been beta testing the Oracle Database 12c In-Memory Option over the past months and recently the Oracle guys interviewed Kerry Osborne, Cary Millsap and me to get our opinions. In short, this thing rocks!
We can't talk much about the technical details before Oracle 220.127.116.11 is officially out in July, but here's the recorded interview that got published at Oracle website as part of the In-Memory launch today:
Alternatively go to Oracle webpage:
Just scroll down to the Overview section that says: Video: Database Industry Experts Discuss Oracle Database In-Memory (11:10)
I might actually be even more excited about the In-Memory Option than I was excited about Exadata years ago. The In-Memory Option is not just a performance feature, it's a simplifying feature too. So, now it's ok to kill your performance problem with hardware, as long as you use it in a smart way :-)


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Second upset not in cards for Foresters at Crossroads tourney
Sunday, February 24, 2013 9:23 AM
The eighth-seeded Huntington University men's basketball team couldn't pull off another upset in the Crossroads League men's basketball tournament, falling to fifth-seeded Bethel on the road, 81-75, on Saturday, Feb. 23.
A game after knocking off the top-seed in the tourney, the Foresters found themselves on the wrong end of a 39-30 halftime score against Taylor. Their 45-42 scoring edge in the second half, however, wasn't enough to add another chapter to its Cinderella story.
Huntington, 17-15, got a game-high 26 points from Shane Merryman. The junior forward made 10 of 15 shots, 6 of 6 at the stripe and also tied for the team-high in rebounds, with six, and assists, with three.
Alec Peterson went 5 for 6 and supplied 14 points to the team's offensive effort, while TJ Short tossed in 10, Colin Featherston and Ryan Boester each tallied nine and Tyler Ault added seven.
Casey Coons and Ben Raichel led Taylor, 21-11, with 25 and 21 points, respectively. The pair shot a combined 14 for 21, sinking 11 of 16 attempts from three-point land.
Nate Kasper also shot the ball well, netting 16 points for the Trojans on a 5 of 6 effort, while Tommy Peller contributed 13 points.
The teams posted even shooting numbers, with Huntington making 28 of 51 attempts for 54.9 percent and Taylor converting on 25 of 47 for 53.2.
The Trojans were sharper from beyond the arc, though, where they made 11 of 20 for 55 percent to the Foresters' 4 for 12 for 33.3, and also the free-throw line, where their 20 for 22 performance for 90.9 percent outshone Huntington's 15 for 22 for 68.2.
Taylor also spread the ball around better on offense, racking up 17 assists to Huntington's seven.


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IlmPath necesitaba un nuevo diseño de otro y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 166 diseños de 18 diseñadores freelance.
Ilm Path Academy - http://www.ilmpath.com
Ilm Path Academy is an Interactive Classical Training Institute offering degrees in Life Skills Training and Religious Studies in weekends at Universities all over the world, and online to a crowd that is mostly university age.
This competition is for a template to be used in all of our courses.
Our students are:
1- Age: from 15 to 30 years
2- Two thirds female, one third male
3- Into religious studies (religious history, scripture, etc) and life skills training, such as success, time management, etc
Template should be in the standard powerpoint slide size, a ratio of 4x3.
You have complete freedom to make the template in any way you want, as we are looking for creativity. We will give detailed feedback to the designs that catch us. (4 or 5 stars mainly)
We have attached two version of our logo, as well as the front of our business card for your inspiration.
In addition, you could get inspired by visiting our website ilmpath.com, as well as viewing other competitions, such as:
- Website Redesign: http://99designs.com/contests/32490
- Flyer Redesign: http://99designs.com/contests/31919
- Business Card Redesign: http://99designs.com/contests/31710
Thank you for your participation, and looking forward to see your designs!


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Fourth Euro star truck christened Albert Einstein
Space station robot delivery van honours physics legend
The European Space Agency's next Automated Transfer Vehicle (ATV) to roll off the production line will be called Albert Einstein.
Space trucks Jules Verne (ATV-1) and Johannes Kepler (ATV-2, pictured above) have already carried supplies to the International Space Station, and will be followed in February next year by Edoardo Amaldi (ATV-3).
Albert Einstein (ATV-4) is being built (see pic) at various sites across Europe, ahead of a 2013 launch. The name was proposed by the ESA's Swiss delegation, since although the physicist was born in Germany, he "studied and spent his early career in Switzerland". ®


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Moore tells daughter it takes help to get made up
September 17, 2013
NEW YORK (AP) — Julianne Moore is known for her milky white skin and striking red hair but the actress says her "camera ready" look is much different than when she's off the clock.
In fact, the 52-year-old tells In Style magazine that her friends tease her for wearing mostly yoga clothes when she's not working.
She also says her 11-year-old daughter Liv recently saw a photo of her and proclaimed, "Mom, you don't look like that!"
The actress says she explained to her daughter it was "the result of all these people working together."
Moore says she appreciates the way a glam squad can make her look "so much better" but it "takes too much time."
The Oct. issue of In Style goes on sale Sept. 20.


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Radar Virtuel
Update - if you are looking for a map tracking the ash cloud over Australia from the Puyehue volcano in Chile see this more recent post.
Live plane tracking website Radar Virtuel has now added the Icelandic volcano ash cloud to its Google Map. It is now possible to not only track the non-existent airplanes in Europe's skies but view the location of the very existent ash cloud.
Currently the map shows the cloud sitting over central Europe with most of the continent presumably praying for the wind to soon change direction and blow the cloud northwards.
Via: Mapperz


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Danielle Knudson – Babe of the Day
Danielle Knudson is another hottie from the Great White North and is today's Babe of the Day.
There's just something about sexy girls from Canada that we just can't seem to get enough of around. Miss Knudson is a model signed to Wilhelmina and Sutherland Models, and is every bit as hot as Canada is wide and cold. She's a statuesque blonde with striking features and sets of stems to die for, if you're a leg man. Even if you aren't all about leggy girls, it's hard to deny that Danielle is a bonafide hottie.
Become a fan of hers on Instagram and Facebook for more of her great pictures.


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First we defined modern marketing, now we can train you in it
If you're interested in what marketing is today, you may have already seen our Modern Marketing Model (M3).
If you're interested in what marketing is today, you may have already seen our Modern Marketing Model (M3).
According to Econsultancy's How Marketers Learn report, over half (55%) of marketers haven't completed a marketing related qualification or training programme.
This is a relatively big proportion, considering the noise about personal and professional development in the workplace.
Michelle Goodall is a social media and digtial marketing consultant, as well as esteemed Econsultancy trainer for our social media courses and our Fast Track Digital Marketing course.
This is a day in her life…
Econsultancy has today launched a microlearning platform, available exclusively to subscribers.
The platform tackles the basic principles of digital marketing and ecommerce in a quick and memorable way. Subscribers can access the microlearning modules through the e-learning section of our site.
Econsultancy would like to invite marketers working at all levels to participate in a short survey about how marketers learn.
The link to the survey is available here.
If you're not constantly testing and tweaking pages on your ecommerce site you could be missing out on potential sales.
But showing is always more powerful than telling, so I'm going to present you with some solid examples of A/B testing in action, along with the results.
It's becoming increasingly true that there is no longer such thing as a job for life.
The average worker today stays at their job for 4.4 years, according to the Bureau of Labor Statistics, and younger people only stay in their roles for only half that time.
Are you on the East Coast of the United States (or love New York) Do you need an in-depth introduction to a variety of digital marketing disciplines delivered by an expert trainer?
Sign up now for Econsultancy's Fast Track Digital Marketing training course in New York.
Taking place over two days starting September 10th, 2015, this intensive course is a great place to start your digital marketing training.
And if you book before August 15th using the code earlybirdNYC you'll get 10% off.
As part of our report titled 'Marketing Pain Points and How to Overcome Them' in collaboration with SmartFocus, we surveyed more than 500 client-side marketers earlier this year to find out what their pain points were.
One of the key points that arose from the survey was a growing concern over the skills gap within the industry.
No one can doubt the importance of enabling employees to develop themselves and learn new skills by attending relevant training sessions.
Not only does it improve productivity and encourage new ways of thinking, but it can have a positive impact on employee satisfaction as it aids career development.
However, in the day-to-day rush to get things done it's easy to see training as a low priority.
Managers are under pressure to meet deadlines so feel they can't afford to let staff take time out of the office for learning and development.
This is an understandable view point but one that is extremely short-sighted, as in the long term it will have a negative impact on productivity and staff retention.
So if you're struggling to convince management of the need to allow staff time out of the office to attend training courses, here are a few arguments you can use to back up your case.
Here is a modern day 'the chicken or the egg' scenario. What came first, a business's digital capabilities or a customer's need for digital relevance from businesses?
Does it really matter? What does matter is that businesses must be digitally wired with a consumer-focused mind set in order to succeed in today's highly competitive landscape.
It's no use letting your ignorance, laziness, or even shame, stand in the way of learning to code. I possessed all three in abundance, until this week I took myself along to a Coding for Digital Professionals course (shock horror, it's run by Econsultancy in London).
The stuff I learned, and the geocities-eat-your-heart-out website I created, got me thinking about all the points in a marketer's life where coding knowledge comes in handy.
In this post I'll reveal more about what I got up to during my first foray into 'the matrix', and I'll list five reasons marketers must have some rudimentary knowledge off HTML, CSS and Javascript.
I'll start with some simple tech info, but read on if you want to see the website I built.