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STOCKTON - A 59-year-old woman was in critical condition and not expected to survive Friday after suffering major injuries in a hit-and-run incident Thursday night, police said.
STOCKTON - A 59-year-old woman was in critical condition and not expected to survive Friday after suffering major injuries in a hit-and-run incident Thursday night, police said.
The unidentified woman was struck about 6:15 p.m. Thursday near Hazelton Avenue and Pilgrim Street, authorities said. Witnesses told officers the victim was stuck underneath the car that struck her, but the driver got out of the vehicle and pulled the victim from under the car before driving away from the scene.
The victim was taken to a hospital to undergo surgery. Doctors offered a grim prognosis, giving the woman a "low expectation of survival," authorities said.
At 10:33 p.m., officers responded to a call of a reckless driver near North California and East Miner streets. The vehicle matched the description of the vehicle involved in the earlier hit-and-run, police said.
Officers located the driver sitting behind the wheel of the vehicle. Felicia Atad, 39, was arrested on suspicion of hit-and-run resulting in death or injury, driving under the influence and driving without a license, police said.
RIPON - Authorities in San Joaquin County fear a teenager may have drowned Thursday in the Stanislaus River near Ripon, officials said.
The San Joaquin County Sheriff's Office's Boating Safety Unit continued its search Friday for Savon Dean, a 19-year-old Elk Grove man who was last seen struggling in the river near Caswell Memorial State Park, authorities said. Dean was not wearing a life jacket, officials said.
Deputies said Dean went rafting with a friend about 2 p.m. Thursday. The friend returned to their campground without Dean about 7 p.m., telling family members Dean needed help.
Sheriff's deputies, the Ripon Fire Department and a California Highway Patrol helicopter searched the area for hours but found no sign of Dean. Deputy Les Garcia, a spokesman for the Sheriff's Office, said the search for Dean and the investigation into his disappearance were ongoing.
STOCKTON - A woman was arrested after assaulting a security guard at St. Joseph's Medical Center about 7:45 a.m. Friday, authorities said.
Sandy Martinez, 54, was kicked out of the emergency room after she became combative with hospital staff, police said. Martinez returned a short time later and assaulted a security guard who tried to stop her from entering the hospital, officials said.
Officers arrived and placed Martinez in the back of a police car, but she continued to be combative and tried to kick the windows out of the police car, authorities said. Martinez was placed in a restraint and taken to another hospital. She was arrested on suspicion of trespassing, battery and resisting arrest, authorities said.
STOCKTON - A firefighter was hospitalized Friday after experiencing chest pains when the Stockton Fire Department responded to a report of smoke at University of the Pacific's iconic Burns Tower, officials said.
Ten firefighters climbed eight flights of stairs to reach the ninth floor of the tower shortly after 10 a.m., Chief's Operator Art Ray said. The firefighter who was taken to the hospital was listed in fair condition and was being kept overnight for observation, Ray said.
The smoke came from a fire in an elevator motor, Ray said. The fire burned itself out, and there was no other damage to the tower, Ray said.
RIPON - Police are searching for a woman who burglarized two cars near Stouffer Park in Ripon and used a stolen credit card at a business minutes after the burglaries occurred, authorities said.
Investigators obtained surveillance images of the woman using the stolen credit card at an ATM, police said. Police later determined that the woman used other stolen credit cards at other locations between Ripon and Stockton, authorities said.
The burglar was described as a woman with a dark complexion, a high ponytail, a pink, low-cut sleeveless shirt, denim shorts and oval-shaped sunglasses, police said.


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PBS' "The Hollow Crown": Richard II like you've never seen him
The latest interpretationof "Richard II" avoids the modern garb, prison setting or Fascist motifs that have marked recent Shakespeare adaptations for TV. Instead, this "Richard II" goes heavy on the theme of Richard as Christ and his death as a sort of crucifixion. That angle's a bit overdone, but this rich and rewarding rendering is powerful thanks to the enduring words, the casting and the terrific performance of Ben Whishaw as Richard.
Whishaw, memorable as Freddie in "The Hour," is rivaled only by Patrick Stewart as aged Gaunt. The two are masters of the craft.
The story goes something like this: a young, waif-like King Richard (Whishaw) is required to settle a dispute between his cousin Henry Bolingbroke (Rory Kinnear) and Thomas Mowbray (James Purefoy). Richard calls for a duel, but then halts it just anyone can be gored. He banishes both men from the realm. Meanwhile a fey Richard plays with his pet monkey and hangs with his guy pals. Richard visits the dying John of Gaunt (Patrick Stewart), Bolingbroke's father, who harshly scolds the king in a patriotic speech ("This blessed plot, this earth, this realm, this England.") Richard seizes Gaunt's money and lands, then leaves for war against the rebels in Ireland. Bolingbroke returns to claim his inheritance. Richard has a moment on the beach in Wales, realizing all is lost. ("For God's sake, let us sit upon the ground
And tell sad stories of the death of kings…"). Supported by his allies, Northumberland (David Morrissey) and the Duke of York (David Suchet), Bolingbroke takes Richard prisoner and lays claim to the throne.
PBS is doing the four-play cycle of histories in chronological order over the next four weeks. Leave it to them to schedule this right in the teeth of the fall broadcast premieres. (Really, PBS?) Set the DVD, save for future generations.

subset: commoncrawl


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DRUMBEAT - Discovering Relationships Using Music, Beliefs, Emotions, Attitudes and Thoughts
An evidence-based social and emotional learning program, incorporating hand-drumming and proven to build resilience and show measurable changes in social behaviour.
Become a DRUMBEAT Facilitator
The DRUMBEAT Facilitator Training Workshop is for professionals who want to deliver the DRUMBEAT Program. Attendees work in a wide range of fields with youth and adults. The 3 Day Course is run by an accredited Holyoake DRUMBEAT Trainer and is the first step towards becoming an accredited DRUMBEAT Facilitator. Find out more about the accreditation process here.
Attendees gain skills in:
Group facilitation skills for youth and adult groups
Managing challenging behaviours
Customising DRUMBEAT for your audience
Program Implementation: teaching Core Rhythms, Games and Improvisation, Group Discussion and Program Evaluation
What is DRUMBEAT?
Music provides us with emotional support; we use it every day to relax, to energise and to connect with others. The Holyoake DRUMBEAT Program embraces this relationship we have with music and opens up a new avenue of self-expression that is fun and free of judgement.
The Program aims to engage people, lift their self-confidence and teach a range of life-skills that will enable participants to be emotionally and socially healthy members of the community.
Under the guidance of a facilitator, participants develop and practice social skills such as problem-solving, active listening, empathy and tolerance through playing music with others.
Their learning is extended through discussion that promotes self-reflection and awareness on how their thoughts, feelings and actions impact their relationships with others.
To learn more about DRUMBEAT, please visit our website www.holyoake.org.au.
Holyoake is a not for profit organisation. By attending events and/or purchasing resources you are supporting the development and delivery of programs and services that benefit members of our communities.
What is included in my ticket?
Every attendee will be provided a Djembe (drum) for the 3 Day workshop, with the option to purchase the drum at a discount upon completion of the Training.
You will also receive a Training Workbook, a Facilitator's Manual, and an audio CD of Program Rhythms.
Morning tea and lunch are included -please advise us of any special dietary requirements you may have when registering.
What do I need to bring to the event?
Bring a pen/pencil and a water botte.
Where can I contact the organiser with any questions?
Email us email@example.com with any questions you may have.
We accept payment online or offline, via cheque or invoice. Our preferred method of payment is online.
Paying Offline - you may pay by cheque or invoice. You will receive a confirmation email upon completing your registration. Your payment must be received in full 14 days prior to commencement of the Event.
Cheque: Cheques payable to Holyoake and mail to PO Box 322, Victoria Park WA 6979
Direct Deposit: Bankwest BSB 306-053 ACC 4168611 (Please reference the invoice number)
Credit Card: By phone 08 9416 4444
International Payments:
100 James St, Northbridge WA 6003 Australia
Swift Code: BKWAAU6P
Substitution - If you are unable to attend, you may nominate someone else to attend in your place at no additional cost.
Event Transfer - You may choose to transfer your registration to another Event, up to 14 days prior to commencement of the Event for which you have registered. If you transfer registration within the 14 day period prior to commencement of the Event, you will incur a $120.00 transfer fee.
Should your circumstances change and you are unable to attend the Event, you may request a refund no later than 14 days prior to commencement of the Event. A cancellation fee of $120.00 will apply. Should you cancel less than 14 days prior to commencement of the Event, no refund will be given.
Refunds will not be given for 'No Shows'. Unfortunately, being unable to attend due to illness/health/personal or work issues is considered a 'No Show', and no refund will be given.
In the event of unforseen circumstances or if minimum registrations are not met, Holyoake DRUMBEAT reserves the right to change or cancel the Event. If the Event is cancelled, you will be notified by the email address you provided and receive a full refund.
Holyoake DRUMBEAT will refund any fees paid, after taking into consideration the relevant cancellation policy. Credit card surcharges are non-refundable. Refunds will only be processed to the credit card or bank account of the individual or organisation from which the payment was received.


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Review: Samsung Series 9 super slim notebook
An ideal Win 7 machine, get it while you can
A process of refinement
There are other changes. The most important peripheral ports are no longer hidden by a door - the USB, mini-Ethernet, HDMI, USB and audio ports are always accessible, on the left of the machine. A nice touch is the mini to regular Ethernet adapter included in the box. A bay-style housing is still present, used to cover the SD card slot when it's not in use.
Port covers are out...
Software includes a backup program, a configuration manager, and Samsung's Fast Boot. Which does what it says on the tin: bringing you to the login screen in around 10 seconds. The only nagware is Norton's anti-virus software.
...easy access is in
Battery life was terrific in real life, giving over 5:30, and typically well over 6 hours in real-life usage, with WiFi on. The display is, as you would expect from Samsung, quite splendid, and as close to matte as you can get these days without actually buying a ThinkPad.
One of the thinnest 15in ultraportables you can buy
The only let down is the keyboard. This is fine by any other standards - but it has a rather tinselly feel, and in such an otherwise well-made machine, was a little incongruous. I should stress, I've used many worse keyboards. And I did like the illuminated indicator light inside the keys for CapsLock and Wi-Fi. Why has it taken laptop manufacturers 30 years to include this on laptops, when regular keyboards have had this for so long?
If Windows 8 worries you, this Windows 7 model is worth seeking out
All in all, the Series 9 is a very well made laptop, with many small but significant improvements made over a year. The question remains – do you want to throw approaching a grand at a 15in laptop when you can get one cheaper? When I posed that question a year ago, those willing to make the investment appeared to be professionals who need to make a statement: a salesman or business owner pitching for some big contract. But it's a question that's much easier to answer this year: the matte-ish expansive screen, slimness and excellent construction make it a very good piece of kit with a broader appeal. Even more so with Windows 8 coming in, so it's worth shopping around for a bargain. ®


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Leisha M. Berry is the author of 'Athletic and Orthopedic Injury Assessment: A Case Study Approach', published 2010 under ISBN 9781934432013 and ISBN 1934432016.[read more]
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urine smells of amonia: Urination is the most important process of our body. Body filter out wastes through urination. The waste is filtered out by the kidney that causes urine odor. Urine mainly consists of water. Urine which contains a large amount of water and less waste product cause no odor. …Read More »
Home >> Tag Archives: urine smells like ammonia in the morning


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Hydro ads put Liberals in contempt of legislature: PCs
A new ad campaign touting a plan to slash hydro rates puts the Liberal government in contempt of the legislature, Ontario's Progressive Conservatives allege.
In a letter to Speaker Dave Levac on Monday, PC House Leader Jim Wilson asks him to find the government in contempt because the ads set out both a timeline for action and assume a decision — this before the legislation to cut hydro rates has been introduced.
"What we've got here is a clear case of electioneering from the Wynne Liberals using taxpayer dollars," Wilson said in a press release.
"Neither MPPs nor the public even know what the new hydro scheme looks like, what it will cost, and who will get left behind. Clearly, these advertisements serve no purpose other than to promote Kathleen Wynne's re-election."
The ads, running on radio stations across the province, tell listeners that the Liberals made important investments in clean and green energy that come at a cost. The rate cut is about addressing the impact on hydro bills, the ads say.
"We've heard you," a narrator says in one of the spots. "Hydro needs to be fair for everyone across the province and we've made fundamental changes to ensure this in the long-term."
Levac said he takes the matter seriously and would rule on the matter. He did not give a timeframe for his response.
Energy Minister Glenn Thibeault defended the ads and said the government has spent under a million on the radio and social media campaign to date. There are more spots coming, likely for television and in print, he said.
"It's important for us to make sure that we let everyone know about the 25% reduction that's coming," he said.
"In terms of the ad campaign, it's going to be in line with all of the other ad campaigns that we've had in the past," he added..
NDP leader Andrea Horwath said the ad buys are particular galling because they have been introduced before the government has introduced its legislation on the rate cut. The ads are clearly partisan and paid for with public money, she said.
"What I think is that we have a government that is in contempt of the people," she said. "Here they are putting ads out without even putting a plan forward. That's not acceptable."


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ITV is the UK's leading commercial terrestrial broadcaster
ITV's broadcasting business is made up of ITV, the largest commercial channel in the country, and the UK's leading portfolio of digital channels - ITV2, ITV3, ITV4, CITV, ITV Encore, and ITVBe. Annually ITV invests around £1 billion in content for its broadcast channels and ITV.com.
ITV is the home of high quality, popular television from the biggest entertainment events, to original drama, soaps, sport, factual series and independent news, both national, and regional.
ITV2 is ITV's entertainment channel for young people, with a range of shows including original scripted comedies and panel shows, American acquisitions, and movies.
ITV3 is a home for popular classic drama series from ITV, alongside a selection of choice factual and entertainment programmes.
ITV4 is great escapism with a mixture of live sport, iconic movies, US acquired shows and cult classics.
CITV is the home for ITV's younger viewers. A mix of animated and live action series for school aged children, including home grown commissions and presentation items created by kids themselves.
ITV Encore has a schedule dedicated to drama, featuring the best of contemporary British drama series from ITV.
ITVBe is dedicated to lifestyle and entertainment programming from the UK and US, featuring real lives, and real people.


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On Thursday Jasmin Enz rushed home from school to bake bread to enter at the Kansas State Fair. She's an experienced bread-maker, but not a typical student nor a regular fair contestant.
Enz is a 21-year-old IFYE (International 4-H Youth Exchange) participant who has been living with the Jerry and Anita DeWeese family for the last three weeks. On Thursday she spent part of the day at Skyline School, visiting a kindergarten class and making a presentation for a geography class.
Until this summer, she had never been to a county fair, much less a state fair. She's looking forward to seeing the butter sculpture and the milking barn, because she lives on a dairy farm in Switzerland.
IFYE is a short-term exchange for 4-H alumni or other young adults, age 19 to 26. She has always wanted to travel and the program doesn't cost a lot of money, while allowing her to see how families live in another country.
Switzerland doesn't have a 4-H program, Enz said; the closest equivalent is a young farmer program.
School looks different between the two countries also. A Swiss student attends school for nine years, then has three years of vocational training. She speaks Swiss German at home, and learned proper German at school, along with English and French. Without an opportunity to practice, the French is mostly gone, she said, but English is spoken in businesses throughout Switzerland.
Enz learned to be a housepainter, but after three years, decided that was not what she wants to do. She worked one winter at a ski resort and lives on a dairy farm with her boyfriend. During the summer, he will have taken the cows to the mountains, but returned each day to make hay, take care of pigs and sheep and bring the milk in to be marketed. By the time she gets home, the cows will probably have been moved back to the farm.
There are living quarters in the barn in the mountains, but no TV or Internet access. Enz said that's not a big deal for farm kids, but young people not raised on a farm would miss the games and social networking, just like an American kid.
She arrived in Kansas in early June and has lived three weeks at a time with four families. She was in Stafford County during fair time. It was nice to see how the kids worked really hard with their animals or other projects, she said, and the rodeo — her first — was a big hit.
Host families have also taken her to various museums, like Old Cowtown Museum in Wichita and Boot Hill in Dodge City. She tried to water ski at Coldwater Lake but couldn't get up. There are lakes near her home, but she said not many people can afford boats.
"I'm better at snow skiing," she commented.
She misses the mountains of Switzerland the most — and really good chocolate.
In Kansas, she liked the county fair the best and the hot weather, although she agreed that 105 degrees was "a little bit too hot, but still okay."
The state fair will wrap up her Kansas experience. On Saturday, she will leave for three weeks in Canada, where she will travel with friends before heading back home.


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Williams-Sonoma shares gain as earnings rise
(4:27 PM ET) SAN FRANCISCO (MarketWatch) -- Shares of Williams-Sonoma Inc. WSM, -2.23% rose in extended trading Wednesday after the kitchenware retailer reported its first-quarter profit rose to $46.1 million, or 48 cents a share, from $39.5 million, or 40 cents a share, a year ago. Analysts surveyed by FactSet had forecast Williams-Sonoma would earn 44 cents a share. Revenue increased to $974.3 million from $887.8 million. The company projected it expects second-quarter earnings of 49 cents a share to 52 cents a share, compared with analysts' estimate of 55 cents a share. Shares climbed 4.9% in after hours.
NetApp earnings rise 13%
(4:08 PM ET) SAN FRANCISCO (MarketWatch) -- NetApp Inc. NTAP, -0.60% on Wednesday reported a fiscal fourth-quarter profit of $197 million, or 59 cents a share, on revenue of $1.65 billion. During the same period a year ago, the data-storage technology company earned $174 million, or 47 cents a share, on $1.72 billion in sales. Excluding one-time items, NetApp would have earned 84 cents a share. Analysts surveyed by FactSet had forecast the company to earn 79 cents a share on $1.67 billion in revenue.
PetSmart tumbles after missing sales goal, lowering outlook
(8:40 AM ET) NEW YORK (MarketWatch) -- PetSmart Inc. shares PETM tumbled in premarket trade Wednesday after the company said it missed its sales goals in the first quarter and lowered its outlook for the rest of the year. "We did not achieve our sales goals, which were impacted by a challenging and volatile consumer environment and a competitive market," Chief Executive David Lenhardt said in a statement. The company said sales totaled $1.7 billion, up 1.1% from the year-earlier period, but below the FactSet consensus of $1.77 billion. The company posted earnings of $1.04 a share, up 6.1% from a year ago and above the consensus of $1.01. Lenhardt said the company expects same-store sales to be relatively flat for 2014 and flat to slightly lower in the second quarter. Shares were last down 8%.
Tiffany raises outlook as profit, sales beat estimates
(7:13 AM ET) NEW YORK (MarketWatch) -- Tiffany & Co. TIF, -2.38% said it earned $126 million, or 97 cents a share, in the first quarter, up from $84 million, or 65 cents a share, in the year-earlier period, boosted by strong sales of fine and statement jewelry. Sales rose 13% to $1.0 billion. The numbers beat the FactSet consensus EPS of 77 cents on sales of $954 million. "Strength in fine and statement jewelry sales continued, while sales of our new or expanded jewelry collections accelerated, led by our ATLAS collection," Chief Executive Michael Kowalski said in a statement. The company raised its outlook for fiscal 2015, forecasting EPS of $4.15-4.25, up from a prior range of $4.05-$4.15. It said it expects sales to rise in the high single digits.
Lowe's posts rise in first-quarter profit, revenue
(6:17 AM ET) LONDON (MarketWatch) -- Lowe's Companies Inc. LOW, -0.12% on Wednesday said first-quarter net earnings were $624 million, or 61 cents a share, compared with $540 million, or 49 cents a share, in the year-ago period. Revenue at the home-improvement retailer rose 2.4% to $13.4 billion from $13.09 billion a year earlier. Analysts polled by FactSet had expected per-share earnings of 60 cents, on revenue of $13.86 billion. "We executed well during the quarter, despite an unexpectedly prolonged winter in many areas of the country," said Lowe's Chief Executive Robert Niblock in a statement. Lowe's raised its per-share earnings view to $2.63 for the fiscal year ending Jan. 30. 2015. Analysts currently expected earnings of $2.62 for 2015. Shares of Lowe's rose 5.5% in premarket trade after the financial results.


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Roger Brown's State of Sports: No growing pains for UNH's MaassBy ROGER BROWN
New Hampshire Union Leader
October 15. 2017 8:24PM
There are a couple of things that make Benton Maass an unusual college hockey player:
No. 1: He's been inserted into the University of New Hampshire's lineup and is playing a significant role as a freshman.
No. 2: He came to UNH directly from high school.
UNH recruited Maass, a 6-foot-2,, 195-pound defenseman, while he was skating for Elk River (Minn.) High School. The Washington Capitals selected Maass in the sixth round (No. 182 overall) of this year's draft.
"We all respect Minnesota (high school) hockey," UNH coach Dick Umile said. "Minnesota hockey is still real darn good. A lot of the Minnesota schools ... I think they missed on him big time, because this kid is a good hockey player. Mike (assistant coach Mike Souza) saw him play and was comfortable with him. He's a good one."
Maass said RPI and Cornell were among the other colleges he considered attending.
"I really liked the campus," he explained. "It wasn't like that huge town feel. I kinda liked it. It was nice and quiet. That was a big reason. I really liked the coaching staff. The players I met on my visit were all accommodating and really nice. I think that really drew me into UNH."
Maass is tied for the team lead in scoring with five points through unbeaten UNH's four games. He collected two assists when UNH opened its season by sweeping a two-game series with UMass-Lowell, picked up an assist in Friday night's 5-0 victory against Colgate and two more in Saturday's 5-3 victory over Colgate
Maass said since arriving at UNH he's been forced to play the game at a different speed.
"Coming into it I think the biggest thing I was focusing on getting used to was the pace of play," he said. "Obviously college hockey's a lot faster than anything I've played before, so I think that was the biggest thing I was looking at — just making sure I was up to pace with everyone."
Maass is one of two freshman defensemen who has made an immediate impact for the Wildcats. Classmate Max Gildon has two goals and one assist in his first four collegiate games.
"We made a commitment," Umile said. "We're gonna play them .. put them out there. If we're going to do well they need to play and get experience.
"Ben Maass is right out of high school. He's a young kid. Max played for the Development Program so he played a fair number of games against college teams. They both have done a solid job."
Maass began last season with the NAHL's Fairbanks Ice Dogs, then returned to Elk River to play his senior season. He went back to Fairbanks once his high school season was complete.
He said he began talking to UNH at the NAHL Showcase and the plan was to always come directly to UNH. "That was what they wanted from the beginning. Yup," Maass said.
UNH captain Dylan Chanter said he's been impressed with Maass' maturity on and off the ice, and called Maass "a really smart guy" in the classroom. He also said Maass doesn't play like a "typical" freshman.
"I'm not surprised he's a draft pick," Chanter said. "You see flashes out there where you know he's destined for good things. He's just been impressive at both ends of the ice — offensively and defensively as well. He's a strong kid and he's got a bright future."
- - - - - - - - - - -
When is a tie not really a tie? When it comes to the NHIAA football standings.
In Divisions II and III, outside of the conference champions, playoff teams (and seeding) are determined by the Football Point Rating, not overall records. If, for example, there are two teams battling for the final playoff spot in Division II and both finish the regular season at 5-3, but one has a rating of 11.3 and the other has a rating of 10.0 there would be no need to study up on NHIAA tiebreakers. The team will the higher rating would be awarded the final playoff berth, even if it lost to the other 5-3 team head to head.
This is something to keep in mind as we enter the final two weeks of the regular season.


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Effective September 15, Snap MarketPlace is no longer available. We appreciate and thank you for your continued support over the years.
You can still shop some of your favorite vendors on each of their agency sites. We have provided their information below. If you cannot locate your vendor, please call 1-866-232-1167 or email firstname.lastname@example.com.


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New 1024-channel StarFire™ SG-1024/M-A delivers superior jetting performance and flexibility for the most widely used dye and pigment based ink formulations with heavy colorant concentrations and fast drying characteristics.
Mumbai, India; November 29, 2012 – At Inkjet Forum India here today, FUJIFILM Dimatix, Inc. introduced the StarFire SG-1024/M-A printhead, the latest addition to its popular 1024-channel StarFire printhead family and one that delivers superior ink jetting performance and flexibility for textile printing and decorating applications.
The company's new SG-1024/M-A printhead shares the StarFire family features of a robust and repairable construction with a high nozzle density in a compact package suited for demanding scanning and single-pass applications.
Designed for easy integration, the compact and self-contained StarFire SG-1024/M-A is built to withstand the harsh environment of industrial textile production. The printhead uses field-proven materials to deliver consistent and reliable output over a long service life, while an enhanced single durable metal nozzle plate allows the SG-1024 M/A to accommodate aqueous-based and UV-curable and Solvent inks needed for digital textile printing and a variety of other applications. Designed to withstand abrasion, the metal nozzle plate is replaceable.
The StarFire SG-1024/M-A combines superior jetting performance with a high nozzle packing density to achieve single-color operation delivering 400 dots-per-inch resolution with fluids in the 8 to 20 centipoise range. The 1024 independent channels on the StarFire SG-1024/M-A printhead are arranged in eight rows on the nozzle plate. Each channel can be fired simultaneously or individually while maintaining excellent channel-to-channel uniformity and jetting straightness at continuous frequencies up to 35 kHz.
As part of the StarFire family, the new printhead incorporates FUJIFILM Dimatix' innovative RediJet™ jetting technology, which is combined with the company's patented VersaDrop™ multipulsing technology to shorten startup and ongoing maintenance times, and deliver high-accuracy, industrial-speed variable-drop jetting and grayscale printing.
RediJet technology encompasses several innovations including nozzle plate design, special surface coatings, enhanced on-head electronics, continuous ink recirculation at the nozzle and waveforms tailored to specific ink requirements.
"These attributes are particularly important for jetting dye and pigment based aqueous ink formulations with heavier colorant concentrations and fast-drying characteristics essential for high-speed single-pass digital textile printing and decorating," explained Russ Brown, Manager of OEM Printheads.
"Together, they unlock the full productive capacity of the StarFire SG-1024/M-A printhead while lowering recurring service costs by minimizing initial start-up and ongoing maintenance times and associated fluids," said Brown.
"VersaDrop technology increases the flexibility of the StarFire SG-1024/-M-A printhead by expanding its fundamental drop size to over 80 picoliters for broader ink coverage and full grayscale printing for job components requiring more tonal expression or higher color saturation, all without penalty to productivity," he concluded.
StarFire printheads are also designed with precise registration points enabling drop-in alignment with system-provided mounting features. This design allows multiple printheads to be accurately arrayed into print bars for wide-width, higher-resolution and multi-color printing devices; it also reduces set-up and alignment costs during replacement or exchange.
About FUJIFILM Dimatix
FUJIFILM Dimatix, Inc., the world's leading supplier of drop-on-demand inkjet printheads for industrial applications, is driving a revolution in inkjet technology to support a new generation of products for printing, industrial product decoration and materials deposition. The company's innovative inkjet technology and world-class fabrication techniques enable OEMs, system integrators and manufacturers to build cutting-edge systems and manufacturing processes for high-performance, precision printing of traditional inks and deposition of functional fluids on all types of surfaces, including flexible substrates.
A wholly owned subsidiary of FUJIFILM Corporation, FUJIFILM Dimatix, Inc. is headquartered in Santa Clara, California and maintains U.S. product development and manufacturing operations in California and New Hampshire. The company sells and supports its products worldwide through offices in the United States, Europe, Japan, Korea, China, Taiwan and Singapore. For more information, visit www.dimatix.com.
FUJIFILM Holdings Corporation, Tokyo, Japan, brings continuous innovation and leading-edge products to a broad spectrum of industries, including electronic imaging, digital printing equipment, medical systems, life sciences, graphic arts, flat panel display materials, and office products, based on a vast portfolio of digital, optical, fine chemical and thin film coating technologies. The company was among the top 10 companies around the world granted U.S. patents in 2011, and in the year ended March 31, 2012, had global revenues of $27.8 billion*. Fujifilm is committed to environmental stewardship and good corporate citizenship. For more information, please visit www.fujifilmholdings.com.
* At an exchange rate of 79 yen to the dollar.
Editors note: To obtain a high resolution photo of the StarFire SG-1024/M-A printhead, please contact Sue DeHavens at firstname.lastname@example.com.


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Send an Instant Message to Jinushigami Using...
3D Special Forces
Community Member
Ichi the Killer <3
Certified Narutard, Inu-tard extraordinare
Anime fan girl
Shikamaru Nara
Hey guys, sorry i've been away for so long. Life has a way doing that to you. I hope all has been well. The point of this blog entry, other than to say herro is some shameless marketing! yay!! i have finished putting together a site for anime themed role-players as well as fan-fiction and original writers as well. YOu should check it out if your interested.
www.animeroleplayers.org is the site. Swing by and say hello ^_^
i would like to start this pilot blog with two words
How much worse is this going to get with him? It was bad enough to strip diabled vets. of vast amounts of benefits that they, unlike every other lazy asshole in this country who hasn't had the motivation to do what EVERY AMERICAN SHOULD, join the service. Sure there are those of you who physically couldn't, because your blind, or in a coma for life so that applys only to those who are physically exempt. These
What song are you listening to right now?
Admit it you want a Snuggie. What design/color?
Do i look like the kinda guy who wants a snuggy... My snuggie is white with long red hair, 125 lbs, 34c and has an incredible singing voice. Not to mention emits her own heat... Love you V
Do you prefer movies at home or movies at the theater?
Home all the way... i would get kicked out of Theaters.
How many songs does your iTunes have?
You get a text at 4AM saying "come outside." What do you do?
Walk outside, my m4 in one hand, my m9 on my hip a scowl on my face and a middle finger as high as it can go in the other hand
Do you get overly emotional about small things?
That my friend is my middle name
When was the last time you were scared?
Second time i rode a harley i came around a corner and hit some loose gravel... leaving a big ol pile of shit behind after somehow saving
The thing about dreams is, that they are Fantasy. Dreams can never come true. Now is this a pessimistic way of looking at life? no. If a "dream" seems to come true then it was never really a dream to begin with, rather just a reality that you were just too blind to see.


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April 26, 2013 (DARWIN, Australia) --A field hockey player has died after he was bitten by a venomous king brown snake in Australia's tropical Northern Territory and then went for a run.
Fairfax Newspapers reported Friday that 26-year-old Karl Berry was cleaning up at Marrara Hockey Centre in Darwin on Tuesday when he picked up a snake. He thought it was a nonvenomous python and threw it into the bushes.
Berry was bitten on the hand but did not realize the bite was poisonous and went on a 1.2-mile training run before collapsing.
St. John's Ambulance operations manager Craig Garraway was quoted as saying Berry was conscious when paramedics arrived. But he took up to 15 minutes to mention the bite. Berry, captain of the Commerce-Pints team, died Wednesday.
Garraway said the run pumped the venom around his system faster.


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Martial Arts Styles
Mixed Martial Arts is the fusion of two or more styles of fighting. Every UFC fighter trains in various systems to create the perfect blend of skills to compete in The Octagon™.
Boxing is a combat sport in which a fighter uses his fists to throw strikes in an attempt to knock out his opponent. Boxing can be traced back as early as 675 BC in Greece, and was acknowledged as an Olympic sport in 688 BC. Nearly every UFC fighter has some boxing training in order to develop his striking skills and some techniques have been modified in MMA. Because boxers stand up straight and fight with their hands, they are not protecting their torso to prevent a take down. UFC fighters have to keep their arms closer to their torso to prevent such vulnerability.
Brazilian Jiu Jitsu (BJJ) was developed in the early 20th century by Mitsuyo Maeda, and focuses on grappling and ground fighting. BJJ is considered a combat sport and a self-defense system and uses submission holds, joint locks and choke holds to subdue the opponent. It is a very effective style in which a fighter can use little to no strength to subdue a much larger opponent. Many MMA fighters train in BJJ to prepare them for grappling and ground fighting, which can be useful when a fighter is up against a wrestler with his back to the mat. The fighter on the bottom can use BJJ to do a sweep (or reverse) to gain the dominant position or to end the fight with a submission.
Originating in Great Britain, this style of amateur wrestling was deemed an Olympic sport in 1904. Wrestlers are scored on their performance and are allowed to use their legs or the legs of their opponents in offense and defense. The ultimate goal is to get the opponent's shoulder to touch the mat (known as a fall) for an immediate win. MMA fighters use freestyle wrestling for its effective take downs, predominantly the single leg and double leg take downs. One of the most practical defenses in Freestyle Wrestling is the sprawl. For fighters that like to keep the fight standing, learning how to effectively sprawl is beneficial because it keeps the fight off the mat.
Despite its name, Greco-Roman Wrestling originated in France and was recognized as an Olympic sport in 1896. Much like in Freestyle Wrestling, wrestlers are scored for their performance, but Greco-Roman wrestling forbids holds below the waist. The result is a strong emphasis on throws since they can't use trips to get their opponent to the ground. UFC fighters rely on Greco-Roman Wrestling to get their opponents against the cage and use the clinch to land.strikes to the body and to the head. The Greco-Roman clinch can also help a fighter take his opponent to the ground.
Many consider Jeet Kune Do's founder, as one of the world's first Mixed Martial Artists. Bruce Lee developed Jeet Kune Do in 1967. Bruce Lee referred to Jeet Kune Do not as a system, but as name he gave his philosophy of freeing yourself from styles and patterns. On the whole, Jeet Kune Do is a philosophy for life, not just combat. Applied to combat, the idea is to use what works and abandon "styles" as they limit your ability to be prepared for a fight. It also noted that what works for one person may not work for another. Jeet Kune Do requires constant training to be ready for anything. Jeet Kune Do is about evolving, and that's what MMA fighters have to do to compete at such high levels.
Judo was created in Japan in 1882 by Jigoro Kano. Its main focuses are throws, take downs and grappling. The goal is to immobilize an opponent and force him to submit via joint locking or strangle holds. Judo throws are very effective in the MMA because typically the fighter who throws his opponent lands on top of him, giving him the perfect position to throw punches or elbow strikes. He can also apply a submission hold from the top position if the opportunity presents itself.
This form of stand up karate allows kicks to the head, but no hand strikes to the head. Founded in 1964 by Masutatsu Oyama, Kyokushin Karate focuses on realistic combat and physical toughness and its main elements are technique, forms and sparring. UFC fighters benefit from the devastating kicking techniques taught in Kyokushin Karate.
Established in Thailand, the kickboxing style of Muay Thai focuses on both striking and clinching techniques. The eight points of contact in Muay Thai include punches, elbows, knee strikes and kicks. There are several types of clinches used, including arm clinch, side clinch and low clinch. Many MMA fighters train in Muay Thai because the style teaches fighters how to throw elbow and knee strikes with enough force to cut or even knock out their opponent while in close proximity (like the clinch).
Developed in China by military officials, this self defense, hand-to-hand close combat system focuses on realistic fighting ability. Competitions are won by knockout or points given for striking and throwing. Sanshou allows knee strikes, kicking, punching and wrestling, but not submissions or grappling. In the octagon, many fighters refer to their throwing skills to get their opponent in a vulnerable position. Sanda and Sanshou aren't commonly taught outside of China, but with UFC's recent acquisition of Chinese MMA fighters, the styles may gain more popularity.
Originating from other Asian arts, Tae Kwon Do was developed during Japan's occupation of Korea and is known for its emphasis on kicking techniques. The belief is that the leg is the strongest limb with the longest reach and can produce a powerful strike, lessening the chance of retaliation. TKD also focuses on strikes, open-hand strikes, take downs, throws and joint locks. Many UFC fighters have a background in Tae Kwon Do.


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November 11, 2009
Table of Contents
Bonnie Goldman: Hello and welcome to HIV Management Today -- a new, clinical management series from TheBodyPRO.com. The debut podcast in the series is entitled: "New Paradigms of First-Line HIV Therapy: Determining When (and With What) to Start." I'm Bonnie Goldman, editorial director of TheBodyPRO.com.
Joining us are two of the top HIV clinician/researchers in the United States. Dr. Eric Daar, is chief of HIV medicine at Harbor-UCLA Medical Center in Los Angeles, Calif., and a professor of medicine at the UCLA's David Geffen School of Medicine. Dr. Trevor Hawkins is founder and medical director of Southwest CARE Center in Santa Fe, and associate clinical professor at the University of New Mexico.
Let's begin with the question of when to start HIV therapy. During the past year or so there have been a flurry of new studies that have called into question when is the optimal time to initiate antiretroviral therapy. Dr. Daar, can you share with us your thoughts?
Eric Daar: I think this continues to be an area for which there has been a lot of discussion and, almost, controversy, because of the limited data to answer the specific question. Clinicians would like to have a randomized control trial to definitely address this issue, and we've never had that. So we've relied heavily upon cohort data, recognizing all the limitations of it. As a result of the cohort data, the bar has shifted. What we've always incorporated -- along with the data supporting a potential role for earlier therapy that would translate into some better outcomes -- is the cost of therapy in, particularly, not dollars, but the toxicity and the risk of selecting for resistance.
I think what we've seen over the last several years is more and more cohort data supporting earlier therapy. We now have a randomized control trial from Haiti that actually demonstrated that people who started antiretroviral therapy with a CD4 count of between 200 and 350 T cells did better than those who started at less than 200.1
We have two cohorts that have demonstrated potentially better outcomes amongst those who start therapy between 350 and 4502,3 or 500, and one cohort that even shows better outcomes amongst those who started with CD4s of greater than 500, versus less than 500.4
The cohorts alone probably wouldn't be sufficient to drive dramatic changes in clinical practice, but it's coming along with the fact that we have so many antiretroviral treatment options that are currently very well tolerated, with extremely high levels of efficacy, relatively low levels of toxicity and low levels of resistance, and many other options. So even if resistance were to develop, we'd still be able to successfully treat patients.
We took the small, randomized control trial, dramatic changes in the types of therapies that are available for our patients and then built on top of that.
One other major observation has come out over the last several years with respect to this relationship between ongoing viremia and high levels of immune activation and inflammation, and how this might affect other end organs -- other than things like the immune system -- such as endothelial function, which can have an impact on cardiovascular disease and renal disease.
And that is that, with all of this, there's an increasing case being built, even in the absence of a large, randomized control trial, for perhaps recommending antiretroviral therapy to virtually every HIV-infected patient who, importantly, is ready, willing and able to commit to treatment.
Bonnie Goldman: Dr. Hawkins, do you agree or disagree?
Trevor Hawkins: I do agree. I agree with Eric particularly in the sense that, if the evidence came from just the cohort studies, then I think we would be more nervous. Because cohort studies have inbuilt potential bias -- both lead time bias and confounding issues that can affect which groups do what. But there's such a body of evidence that replicating virus is just not a good thing in almost any infection, particularly one as widespread as HIV, which affects so many different body compartments.
As Eric said, we clearly have evidence that ongoing viremia leads to high levels of immune activation. You can measure that by measuring immune activation markers. This, in turn, drives inflammation. And inflammation is a big buzzword these days. It clearly affects organs; it affects blood vessels; it affects endothelial function.
We have a lot of data, too, on CD4 counts and how important they are. A lot of cohorts have suggested that non-AIDS events, non-AIDS malignancies, cardiovascular disease, renal disease and liver disease are related to nadir CD4 count. A study from France, from Charlotte Lewden, M.D., Ph.D., looked at 2,300 patients from the boosted-PI [protease inhibitor] era in a couple of French hospital cohorts, along with a well-matched HIV-negative cohort.5 And although the mortality rate was seven times higher in the HIV cohort, those patients who reached a CD4 count of 500 and above had the same mortality rate as the HIV-negative cohort.
So, it's not a definitive study, but more grist to the mill. There's this growing sense that HIV replication, if left unchecked, is just not a good thing.
One thing we haven't mentioned is neurocognitive function. There was some recent data this year from the CHARTER cohort, suggesting that neurocognitive function is significantly impaired in up to half of that particular cohort, and that function is directly correlated with nadir CD4.6
There's a growing body of evidence that I think a lot of us -- and I'm one of them -- believe is sufficient reason to offer antiretroviral treatment to anybody, again, as Eric said, and very importantly, when patients are ready to start therapy.
One further point I would make is that, I know in my neck of the woods, in New Mexico, 60% of newly diagnosed patients here have a concurrent diagnosis of AIDS. They are presenting late. So, to some extent, you could argue that the argument around the data is somewhat academic, although it's still important.
However, we have data from D.C. that suggests that as opt-out testing is made more available, the CD4 count at the time of diagnosis does, in fact, go up -- theirs went from around 200 in 2002 up to around 300 in 2007, largely linked, we think, to newer testing.7 So I do think that if widespread opt-out testing becomes more accepted, this argument on this issue will become more and more relevant.
Eric Daar: I agree with Trevor. I think that there are a lot of other issues that we need to sort out that may be very important in this question about when to start.
The neurocognitive issues are extremely important, and I agree, there are several studies that seem to suggest that it is the CD4 nadir, or how advanced someone's disease was, that defines the level of neurocognitive dysfunction, more than their current CD4 or viral load. So there may be ongoing neurologic damage -- almost certainly is -- during the course of the disease that may be only partially, or maybe not at all, reversible.
I think other comorbidities are also important to consider. Even though people with relatively high T cells probably have a relatively low absolute risk of things like death and progression to clinical AIDS, at the very least, serious consideration of other comorbid conditions might influence the decision. We know that ongoing viral replication may predispose people to things such as renal, liver and cardiovascular disease. So patients who have underlying organ dysfunction, for any one of a number of reasons, in these areas might use that as an additional excuse to consider starting therapy earlier than they might have otherwise.
I think both the U.S.8 and European guidelines9 have increasingly -- over the last several years -- taken these comorbid conditions into consideration, and suggest that they be part of the discussion with an individual patient about when therapy should be optimally started.
Trevor Hawkins: I know hepatitis B is clearly indicated in our guidelines. Hepatitis C, I think, is mentioned in the European guidelines. It would be interesting to see if the new U.S. guidelines, which are due fairly soon, will mention hepatitis C. Because clearly HIV accelerates the progression of hepatitis C where that's a comorbidity.
I might also mention bone disease, which seems to be more common. Both osteopenia and osteoporosis are more common in patients with HIV disease.
One thing we haven't mentioned, though it is clearly as important, is that there's very strong data to suggest that an undetectable viral load very significantly diminishes the risk of transmission.10 Since the CDC [U.S. Centers for Disease Control and Prevention] estimates that half of all new infections are derived from people who don't know they are HIV positive, testing those people and treating them will hopefully reduce the incidence rate.
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|Sex and the HIV Reservoir: New Research Points to the Powerful Effect of Estrogen
|First U.S. Failure of Truvada as PrEP Is Reported at IDWeek
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|High Rates of Anal HPV Infection in Gay Men Using PrEP in IPERGAY: The Role of Vaccination


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Any/all necessary entertainment whilst taking a shit, i.e social media on cell phone, Sports Illustrated, flappy bird, etc.
"Dude I left my phone at home so now I don't have any shittertainment"
by @joebagsgarbagepretzel February 19, 2014
Any type of entertainment, ranging from newspapers and magazines to psp's and cell phones, that you bring into the bathroom and use to occupy your time while on the shitter.
Person 1: Hey, could you pass me the sports section of that newspaper?
Person 2: Did you forget to bring any shittertainment with you?
Person 2: Did you forget to bring any shittertainment with you?
by Hamsterrrrr September 03, 2008
(Noun) - The item or culmination of items scrambled for when one has to perform a bowel movement, often readable. For convenience these items can be located at a throne side containment device, often ornate. On the contrary, pending the urgency of said duties a feverish scramble can ensue for shittertainment. Shittertainment can be as simple as a magazine however is often a smart phone or tablet. In desperation, could even be unread mail or even a cereal box.
Sup brah, you got any shittertainment in your crib? I gotta drop it like it's hot.
I need to pinch this one off, I don't have any reasonable shittertainment.
I need to pinch this one off, I don't have any reasonable shittertainment.
by Buster McGuiness August 26, 2014
buy the domain for your pet blog


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WASHINGTON, U.S. - In what became the most high-profile Chinese deal to be torpedoed under the U.S. Trump administration, a U.S. government panel rejected Ant Financial's acquisition of MoneyGram International Inc.
The companies said on Tuesday that the deal was rejected over national security concerns.
According to sources familiar with the confidential discussions, the companies terminated the deal after the Committee on Foreign Investment in the U.S. (CFIUS) rejected their proposals to mitigate concerns over the safety of data that can be used to identify U.S. citizens.
MoneyGram Chief Executive Alex Holmes said in a statement, "Despite our best efforts to work cooperatively with the U.S. government, it has now become clear that CFIUS will not approve this merger."
Sources noted that while a standard CFIUS review lasts up to 75 days, the companies had gone through the process three times in order to address concerns.
Adding that the additional security measures and protocols that the companies suggested had failed to reassure CFIUS.
Declining to comment on the MoneyGram deal, the U.S. Treasury said it is prohibited by statute from disclosing information filed with CFIUS.
The collapse of the $1.2 billion deal to acquire the U.S. money transfer company by China's Ant Financial represents a blow for Jack Ma.
Jack Ma is the executive chairman of the Chinese internet conglomerate Alibaba Group Holding Ltd, who owns Ant Financial together with Alibaba executives.
According to reports, Jack Ma had been looking to expand Ant Financial's footprint amid fierce domestic competition from Chinese rival Tencent Holdings Ltd's WeChat payment platform.
In a meeting a year back, Ma had promised Trump that he would create 1 million U.S. jobs.
On Tuesday, in after-market trading, MoneyGram shares were down 8.5 percent at $12.06.
Meanwhile, Ant Financial and MoneyGram said they will explore and develop initiatives to work together in remittance and digital payments in China, India, the Philippines and other Asian markets, as well as in the U.S.


text: I'm not sure if this is virus related or not, but... When ever i click on the OE icon, the busy pointer shows, but nothing happens. I;ve check the properties and all, the root is where its mean to be, but it wont open even if i do a start run on the .exe Whats wrong! Ive found a temporay solution, by creating or using a different profile, it works, but i've had to create two new ones because thi has happened twice. Any help?


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With more than 100 models, FANUC offers the widest range of industrial robots in the world, ranging from 0.5kg-2300kg in payload for any application or industry.
With more than 3 million CNCs installed worldwide, FANUC CNC systems provide the lowest Total Cost of Ownership and the highest Mean Time Between Failure rate in the industry.
ROBODRILL high-speed, high-precision machining center with FANUC standard CNC installed addresses all machining needs for its class.
FANUC provides lifetime maintenance on all products for as long as they are used at more than 250 service locations in 45 countries throughout the world.
FANUC CERT Schools now offer the first-ever standardized national assessments to earn your certification for Robot Operators & Technicians. Start learning today.
FANUC America produced a procedure guide to help our customers overcome the challenges of damage from floodwaters.
Designed for tight workspaces, FANUC's new seven-axis robot will add a new level of versatility to your operations. Meet the all-new FANUC R-1000iA/120F-7B robot.
From aerospace to woodworking, FANUC America offers industrial robots for almost any application with payloads ranging from .5kg to 2300kg. FANUC ASI's are ready to analyze your system requirements and provide a robotic solution that will improve quality, throughput, and productivity to give you the return on investment you are looking for.
We offer Certified Education Training (CERT) to qualifying high schools, community colleges, and universities.
FANUC America offers a variety of training options to customers for all products.
FANUC's lifetime product service is unmatched in the automation industry. Let us work for you.
Our YouTube channel has hundreds of case study videos in a variety of applications & industries.


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interesting article putting the ankara assassination photos in an art historic context. i don't mean to glorify the action, terrorism or death, but they are captivating, uncanny images. because they were taken by the professional photographer on hand at the gallery opening, the images don't have the rushed, blurry look of shots captured by a panicked ordinary citizen on an iPhone. the images are clear and expertly framed, as if the scene was composed.
(EDIT: is there any talk about the photographer working in partnership with the assassin? seems like he's either extremely brave to have stepped up, ignored the danger and taken these photos, or an accomplice.)
alternatively, it also like a maurizio cattelan installation, if he lost his sense of humor.


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Gallery: The Ten Most Pissed Off Looking Cats From The Algonquin's Cat Fashion Show
In honor of the birthday of its feline mascot Matilda, New York's Algonquin Hotel holds a cat fashion show each year. This would be a great idea, if 1.) cats enjoyed wearing clothes, and 2.) cats knew what the fuck a fashion show is. As it is, it seems more like an indicator of who should maybe have their pets taken away by animal control than the glamorous couture parade its participants seem to fancy. Nonetheless: it is hilarious. Here are the top ten most pissed off looking cats from this year's extravaganza.
(Photos via Time Out New York)[ITPGallery]


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Best Summer House Tours: Around the World
One of the things I love about the Internet is its ability to link people together who live thousands of miles apart. We have over 70 bloggers working for Apartment Therapy, some of them as far away as Japan and Australia, and they send in some really incredible house tours from their travels. And, of course, we post loads of great tours from the US as well. I was recently surfing through some of my old favorites and I realized that we have a ton of tours from across the globe that capture all types of summer style, from a surf shack in California to a windswept cottage in Kenya. Enjoy!
Name: Shaker Brick House
Location: Tiny Shaker village
Type: 1800s brick house
Years Lived In: The same family has owned this house since the 1800s
>> Pete and Sandy's Minimal Farmhouse
Name: Pete and Sandy
Location: East Washington, New Hampshire
Size: 1660 square feet (includes porch)
Years lived in: 36 Years, Fully Restored 2006-2008
Name: Tereasa and David
Location: Elkhorn, Wisconsin, on the grounds of Tereasa and David's summer camp
Size: 10 x 10 square feet
Type: Half-sawn log cabin from a prohibition-era motor cabin court
Years lived in: Guest cottage on our summer camp for 3 years
>> Layla and Kevin's Country Coastal Cottage
Name: Layla and Kevin Palmer
Location: Prattville, Alabama
Size: 1,910 square feet
Years lived in: 2 years
>> Mike and Angela's Weekend Escape
Name: Mike and Angela Barnhill
Location: Kill Devil Hills, NC
Size: 1,124 square feet
Years lived in: Weekends since 2007
>> Mason and Serena's Sunset Beach Bungalow
Name: Mason St. Peter and Serena Mitnik-Miller
Location: Outer Sunset, San Francisco, CA
Size: 400 sq. ft.
Years lived in: Mason: Since July 2007, Serena: Since July 2008
>> Shawn and Amy's Laurel Canyon Retreat
Name: Shawn Gold and Amy Neunsinger
Location: Laurel Canyon area of Los Angeles
Size: 5,500 square feet
Years lived in: 2 years since remodel, 8 years total
>> Tina's Port Douglas Cottage
Name: Tina, Matthew & Pablo
Location: Port Douglas, QLD, Australia
Size: 98 square meters [1060 square feet]
Years lived in: 3 years, owned
>> Martina and Manfred's Country Dream
Name: Manfred & Martina aka Wohnkultur
Occupation: Scandinavian Furniture Dealers
Location: In the countryside, South of Hamburg, Germany
Type: Old German Farmhouse
Size: 6000 sq.ft.
Years lived in: Many!
>> Helen and Frazer's Solar Powered Beach Shack
Name: Helen & Frazer Cunningham
Location: Cowes, Isle of Wight, UK
Type: Beach Shack
Size: Dolls House!
Years lived in: Owned for 4 years
>> Karina's Countryside Creation
Name: Karina's Parents — Marianne and Bent
Location: Holbaek (2 hours northwest of Copenhagen, on a fjord)
Size: 1,000 square feet, 1 bedroom vacation home
Years lived in: 3 years worth of summers/holidays
>> Tamsin's Windswept Dune Cottage
Name: Tamsin Corcoran-Brennan
Location: Tana River Delta, Kenya
Size: Several hundred square feet
Years lived in: Two years
Name: Florence Masson
Occupation: Retired from Interior Design. Now a part-time artist painter.
Location: Yzerfontein, West Coast, South Africa
Type: Cape Cod Style House
Size: 3,200 square feet
Years lived in: 3
Name: Olivier Van Reeth
Occupation: M.D. specializing in Sleeping Disorders
Location: Marrakech, Morocco
Size: 3000 sq.ft.
Years lived in: 8, owned. This is his holiday home, he usually spends his time between Brussels and Rome.
>> Becke and Lee's Vintage Cabin
Name: Becke, Lee, Pierre and three geriatric cats (Badooda, Magiggles and Einar)
Location: Lakeport, Ontario, Canada
Size: 1800 square feet
Years lived in: 1


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Twitter's Founders: Where Are They Now?
By Yoree Koh and Shira Ovide
Before Twitter became a social media phenomenon, it was just an idea. Here's brief look at Twitter's quartet of founders:
Evan Williams / @Ev: The laid back founder
His Role in Twitter's Origin Story: Williams will always be the guy whose failed startup idea brought Twitter to life. He was slaving away on a company he created called Odeo, which helped people find and make audio podcasts, and then iTunes came along and crushed his company. With leftover investor money, Williams gave Odeo employees a chance to noodle around with new ideas, and Dorsey suggested a short-message service that became Twitter.
What Is He Doing Now? Williams was pushed out as CEO and replaced with Dick Costolo in 2010. With Biz Stone (see below), Williams created Medium, a Web-publishing platform that has grown popular with the digerati.
Fun Fact: Williams has said he grew up on a Nebraska farm, "90 miles and an eternity" from Lincoln.
Biz Stone / @Biz: The creative founder
His Role in Twitter's Origin Story: Stone, an ex-Google employee, was part of the Odeo brainstorm team that eventually sculpted Dorsey's idea into Twitter. He has served as the company's creative director, but stepped away from participating in Twitter's day-to-day operations in 2011, at the same time as Williams.
What is He Doing Now: In 2012, he teamed up with his old pal Williams to co-found Medium, a publishing platform. He has also been an active investor, putting money into various startups including Dorsey's Square.
Fun fact: He has been known to hit up the conference circuit, charging an average $75,000 per speaking engagement.
Jack Dorsey / @Jack: The superstar founder
His Role in Twitter's Origin Story: Twitter hatched from the St. Louis native's lifelong obsession with services that dispatch emergency vehicles or taxicabs, and the way drivers quickly and frequently conveyed their locations over the radio.
Dorsey in 2000 was working at LiveJournal, an early collection of blogs, and had an idea to let regular people do quick status updates as cab drivers and dispatches did. He refined the concept for years and finally got a chance to put the idea to the test when he worked for Odeo.
Dorsey's claim to fame is he sent the world's first tweet: "just setting up my twttr," he posted on March 21, 2006. (The company was originally called "twttr" -- in part because the Web address Twitter.com was already taken, co-founder Biz Stone told The Wall Street Journal recently.)
What Is He Doing Now: Dorsey is the chairman of Twitter's board, and he founded and runs hot mobile-payments startup Square. He also remains very active with Twitter. Last year, he found a digital-video startup called Vine and convinced Twitter to buy it. At one point, Dorsey said he was spending eight hours a day working on Square, and eight hours on Twitter. Yes, that is a 16-hour workday.
Fun Facts: Dorsey is the coolest dresser in Silicon Valley -- no contest. He's so cool that he has become known for a signature reverse collar shirt. Esquire has a "Jack Dorsey Style Scale" to rate tech moguls' sartorial style compared to Dorsey's. He also may be the world's biggest proponent of "selfies" -- photos or videos of yourself, shot on a smartphone.
Noah Glass / @Noah: The founder of mystery
His Role in Twitter's Origin Story: Glass worked in the coding trenches with Dorsey to turn his idea into a real service. But Glass, who co-founded Odeo with Williams, will be most remembered for being the one who came up with the name Twitter.
The problem is, most people don't remember him. That's mostly due to the fact he was pushed out of the company before it exploded into the social sharing beast that it is today, then largely left out of the company's historical narrative.
"I felt betrayed by my friends, by my company, by these people around me I trusted and that I had worked hard to create something with," said Glass in an interview with Business Insider.
He left in 2006, following disagreements with Williams over the direction of the company, including who should lead it. (Glass reportedly wanted to be CEO, but the honor went to Williams.)
Dorsey gave Glass proper credit for the company's name in 2011--fittingly, in a series of tweets.
What is He Doing Now: We'll let you know when he resurfaces. Unlike the other three founders, who have all been extensively profiled in the media, little is known about what Glass is up to these days.
According to the Business Insider interview, after his unceremonious exit from Twitter he dabbled in games before moving to Los Angeles to work on an "alternative energy system." He later moved to San Francisco.
But he's largely fallen off the digital map since 2011. He only tweeted three times in 2013 and before that was silent since 2011. His blog hasn't been updated since May 2009.
Fun Fact: Another Noah Glass on Twitter makes clear in his profile he's not THAT Noah Glass.


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PathPix Joy Review
- Publisher: Kris Pixton
- Genre: Board
- Released: 22 Mar, 2012
- Size: 14.0 MB
- Price: $0.99
- More Pathpix puzzles to enjoy for fans of the series.
- The final picture and quote is always guaranteed a smile.
- The sound effects are very annoying.
- More for veterans of the series than newcomers.
Pathpix remains of the most unique and enjoyable puzzle games on the app store, and this latest offering is no exception. With that being said, this is more for those familiar with the patterns of the game and might be a little too frustrating for newcomers.
- Full Review
- App Store Info
Pathpix Joy is the fourth game in the Pathpix series. What is Pathpix you ask? Well we could tell you to go check out our reviews of the original, but we're going to be nice and tell you here. Pathpix is a favorite amongst puzzle games here at AppSpy. Andrew has made his way through the multiple offerings while all these years later, I'm still playing the original. It's elegant, doesn't require too much straining of your brainy lobes, and upon completion of a level, offers not only the picture you helped create but either a thought provoking, humorous, or inspirational quote as well. As rewards for completing levels go, it still remains one of the better offerings out there.
Now the latest release Pathpix Joy is not for newcomers. If you're intrigued by the introduction or by the gameplay shown in the review video thus far, do yourself a favor and either grab the lite version of Pathpix, or the game itself. Pathpix Joy does start small, but the patterns used assume a familiarity with the previous titles. The original game slowly introduces longer and longer strains of numbers in more complex patterns that become second nature the more levels you play. Pathpix Joy starts off with some of these more complex patterns and in its first ten levels rolls out patterns of nine, ten, and even eleven spaces.
As with the previous games the idea is to use your finger to connect two numbers by drawing a line between them that features that number of blocks in their connection (including the start and end point). Double tapping on the line will remove it, and the level is completed when every space on the board is filled, creating a pixelated picture (a pix created by paths if you will). Like the previous offerings, there's a large block of content to work your way through with some advanced levels at the very end.
The only criticism of this game aside from not being friendly to newcomers is the sound effects. Within a couple levels, the sound was turned off as the chimes and chirps while playing the game became almost unbearable. For fans of Pathpix, this is another great batch of content for the series, which is one of the best puzzle games on the app store in our humble opinion.
DescriptionSunrise to sunset and on into the night, PathPix Joy will keep you smiling with 99 puzzles, easy to extreme.
Universal edition - play in landscape or portrait mode on all devices running iOS 7 or later.
Draw bright, bold lines of color to make paths connecting pairs of colored numbers. The length of each path must equal the numbers you are connecting.
Finish solving to see the miniature picture that you have created. As an extra reward you get a quote related in some way to the picture. Witty or wise, it will give you a little something to think about as you go on to the next puzzle.
Not sure which PathPix to buy?
Here's the lineup:
There are many different PathPix apps for your iPhone and iPad. All puzzles are different.
---PATHPIX LITE: Wondering if PathPix is for you? Start here. It's free!
---PATHPIX: Hooked? This is the next step, with 189 graduated levels, ranging from small, easy puzzles to large, advanced level puzzles.
---PATHPIX PRO: Are you an expert? Looking for a LOT of puzzles? Then PathPix Pro is for you, with 320 puzzles ranging from Medium difficulty to Extreme.
---PATHPIX ZEN: Relaxing and addictive! 99 beautiful puzzles, including an Advanced Levels section with 12 special challengers.
---PATHPIX JOY: Keep smiling! 99 puzzles = many happy hours of PathPix fun. Small to large, easy to advanced - you'll find it all here.
---PATHPIX MAGIC: Magic of all kinds! 99 puzzles, small to huge, easy to advanced.
---PATHPIX LAUGH: Lots more puzzles to tickle your funnybone. 202 puzzles, each with a silly joke or quote related to the puzzle picture. Small to large, easy to extreme.
---PATHPIX BOO: Silly - spooky - scary - fun! 99 puzzles for Halloween and other dark nights.
---PATHPIX XMAS: 99 puzzles with a Christmas theme to get you in the mood for the holidays. Whether you are looking for sentiment or silliness, you will find it here.
---PATHPIX LOVE: All you need is love! 99 puzzles, easy to advanced.
---PATHPIX MAX: By far the biggest PathPix puzzles ever. 114 GIANT-sized puzzles, over a million squares total!
What people say about PathPix
"Best Numbers Game - PathPix. In PathPix, the goal is to create a picture using numbers that connect to one another by bright, bold lines of color. Ranging from very simple images to sprawling and complex masterpieces, Pathpix is a logic game that rewards your dedication with an interesting bit of math-made art. You'll also get a nice historical or literary quote as a reward as well ... this game is so addicting you might just feel the need to solve them all." - www.slidetoplay.com
"PathPix ... is a harmonious blend of drawing, connect the dots, and find the hidden picture. ... Touch controls are very intuitive and work well. PathPix offers a wonderfully addictive gaming experience." - by the AppSmileTeam
"PathPix ... is a superb implementation of the numbers-linking puzzle for iPhone and iPod Touch users." - by JohnB, JayIsGames
Simple rules - complex puzzles - hidden pictures!
Draw bright, bold lines of color, connecting pairs of colored numbers. The length of each path must match the numbers on the two endpoints. Draw backwards or double tap to correct mistakes. There's only one way to do it, and all squares will contain a piece of a path when the puzzle is solved.
Two ways to navigate while solving:
---Tap the zoom button for an overview, then touch the screen where you want to play next.
---Pan to show another area of the board. Put your finger down any place WITHOUT A NUMBER and move it around. Simple, intuitive, fast.
PathPix Joy is based on the PC game "PathPix" by KpixGames.
What's New in Version 2.1Fixed problem that caused random crashes for some players after recent iOS updates
New setting allows player to select one of 3 coloring schemes for number rings
Improved drawing speed and clarity
This is the SECOND video today that is "private"
How hard can it be to THINK for a minute BEFORE you post the aricle and set the video to public?
Stooney - these articles are published while I'm sleeping. This is a timing problem with YouTube and I'm sorry to say I can't control when they publish my videos, despite setting an exact time for them. I will endeavour to find a solution that works and apologize for the delays.


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The existing model of locating biopharmaceutical manufacturing in classified cleanrooms is being re-examined as the biopharmaceutical industry aims to improve patients' access to products by reducing costs, while maintaining assurance of product quality and patient safety. The evolution of verifiably closed-manufacturing technologies is replacing open systems, thus removing the need for the extensive use of costly, classified environments as a risk-mitigation measure. By putting technical and procedural advances together with scientific and quality risk-based approaches, many industry leaders are improving process equipment systems such that reduced area classifications (grade D/ISO 8 at rest) and controlled non-classified (CNC) environments are now deemed appropriate for functionally closed systems and closed bulk drug-substance bioprocesses. The approach is one step towards helping reduce capital and operating costs, and thus product cost, which is a factor in improving patient access.
This article follows on from a previous publication (1) in which the authors discussed the trend towards manufacturing bulk-drug substances in areas of lower classification for a dedicated single-product facility (1). The authors suggested potential risk-mitigation approaches to protect product quality and minimize operator safety risks, and also provided estimates of the capital and operating cost benefits. This article considers the potential additional risks that concurrent multi-product manufacturing in a common/shared ballroom facility introduces. The premise is that the concepts discussed in the prior publication—extensive use of closed processing in a CNC environment—are successfully applied. It also seeks to meet industry regulations for formal risk-management approaches (QRM) (2) to the design of facilities, especially because the updated EU Annex 2 mentions risk early on and extensively (2).The focus of this paper envisages typical combinations of biological product classes within the same CNC ballroom facility. The industry may be ready for multiproduct processing in a facility design that is radically different from those found in use today. Certain product classes, product properties, or host systems may still require dedicated facilities or specialized containment equipment to minimize the risk of operator exposure or cross-contamination.
For industry participants to have a meaningful dialogue around these concepts globally understood and accepted definitions need to be established. The authors are grateful to the leaders of initiatives within ASME BPE, and ISPE, which are creating definitions that will be adopted by the pharmaceutical industry. Draft wording from this work is included in the online extended version of this article found on http://BioPharmInternational.com/.


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Common Core coming to Manchester classroomsBy TED SIEFER
New Hampshire Union Leader
August 27. 2013 10:34PM
MANCHESTER — The Common Core State Standards will start being implemented in city classrooms this semester, despite the concerns expressed by its critics and some school board members.
Superintendent Debra Livingston presented sample curriculum guides at a meeting of the Curriculum and Instruction Committee Tuesday. The guides were produced by city teachers over the summer under the guidance of a consultant hired by the district.
The meeting was attended by around two dozen members of the public, several of whom spoke out against the state standards at the beginning of the session. Opponents of Common Core claim it is a federally imposed system that relies on unsound educational principles and will undermine local control.
Livingston countered that the standards were meant to prepare students to compete in today's world and were based on sound research, echoing the arguments of state education officials.
"We have been using a system that teaches a mile long and an inch deep. What Common Core does, it has shifted those ideas to make sure students are understanding at a very deep level," she said.
Livingston also said that the district was "two years behind" other communities in the state in rolling out the standards.
Members of the committee expressed reservations about approving the curriculum guides, since they were only presented with two examples, for Grade 2 English Language Arts and for Grade 7 Math.
Rather than vote to approve the guides, the committee tabled the matter, while giving Livingston the authorization to move forward in instituting the changes this year.
"This would really be a pilot program," said Ward 1 board member Sarah Ambrogi, the chair of the committee.
Livingston also confirmed, in response to questions raised by members of the committee, that $21 million in federal funding was at stake if the district didn't adopt Common Core.
The opponents of the standards said their research caused them to be very concerned.
Patrice Bernard, who said she home-schools her children, said the recommended reading material included books on tools, which she noted would likely be uninteresting for second-graders, and a book that was written in English and Spanish.
"In my house, we don't say mi casa is su casa," she said.
Education Politics Social issues Manchester Top Section Stories


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I used to have lawn.... Now I have dinner!!
We are now nearing the end of our first season with a "lawn-less" front and side yard, where we have planted an edible landscape. The preliminary results are in- success! I have been up to my elbows in tomatoes and have so far canned salsas, pasta sauces, pizza sauce, and whole tomatoes to enjoy when winter creeps in. We have also enjoyed lettuce, fresh strawberries and raspberries, watermelon, eggplant, green beans, kidney beans, and black beans, cucumbers (and pickles), swiss chard, zucchini, red peppers, hot peppers, rhubarb, potatoes and a variety of herbs.
This was not a small undertaking. When we planned to get rid of the lawn, I pretty much knew I would be devoting my summer to the garden. But happily. Sean and I both hate to mow, and we never got much satisfaction from are perpetually half-dead lawn. We found no joy in walking around clumsily in our spiked aerating sandals or in spreading the (albeit organic) weed-n-feed fertilizer concoction each spring.
The alternative, for us, is a labor of love. Well, and of sustenance. We have cut our grocery bill at least in half, and we are feeling really good about eating fresh, local, chemical-free food. I have no idea what this does to our carbon foot-print, but when I learned that a single head of lettuce that travels from California to my table has something like 50 times the carbon footprint of that grown in my own backyard, it was hard not to take note.
We have, of course, supplemented our harvest with meats, dairy, and other things we can't find in our backyard (although much of it has come from the local co-op, which is conveniently a half-mile down the road.) We have also become more aware of nutritional values of different foods, more creative cooks, and less reliant on processed food.
Next year's garden plan will be tweaked a bit. (I've learned I DON'T need 75 tomato plants, for instance.) Soil will be amended, bed locations changed a bit to maximize sun... and, yes, there will likely be even more garden and LESS lawn as we add even more edible space.
Visit the Blue Planet Garden Blog to see how others are changing their landscapes. Lawn Reform, a collaboration of nine bloggers from around the US, is trying to reshape how we all think about lawns and their roles in gardens.


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calling all yogi'sTuesday, February 18, 2014
I'm sure you have seen these. Some people call them pedicure socks. Others use them for yoga. I happen to think they are great for both.treehugger warmers. I really like this website. They sell the item or a kit to make your own. Genius.
I bought a kit, cause, hey, I LOVE to knit!
This pair is headed to my sister, Lisa. To use while teaching or during her own practice. I definitely have a few more of these in my knitting future.
Pattern: Treehugger Warmers
Yarn: Wool and the gang, 100% Peruvian Pima Cotton, midnight blue.
Needle size: US 8
Notes: Easy and Fast!


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Today's Meditation
Read John 1:1-5
The Son is the radiance of God's glory and the exact representation of his being.
-Hebrews 1:3 (NIV)
On a clear and windless day, a smooth lake can reflect an almost perfect mirror image of the landscape around it -- often creating scenes of stunning beauty.
Jesus Christ is more than a reflection; he is the exact representation of God. As we read stories about Jesus' earthly ministry -- how he taught and healed and ultimately died for us -- we are prone to lose sight of that most important truth; Jesus is God (John 1:1). When we look at Christ, we see who God is and what God does.
Christ, who stepped out of the realms of glory in heaven to reach out to each of us, is the very God who created the universe. Not only did the Living Word create the cosmos (John 1:3, Col. 1:16), but Christ also sustains and holds the creation together (Col. 1:17). And yet this all-powerful Creator loves each of us personally and individually and bids us come close.
Every time we see beauty reflected, we can think of and give thanks for Christ, the exact representation of God. And yet he is much more than a reflection. When Jesus said, "I and the Father are one" (John 10:30), that is exactly what he meant.
Michael J. Reynolds
(Florida, USA)
Prayer: Dear heavenly Father, thank you that your son reflects your love and compassion for each of us. Help us to reflect your nature to those you place in our path. Amen.
Thought for the Day: When we are like Jesus, we show God to the world.
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Part of the value of the critical sample may simply be the proof that the symptoms are indeed due to hypoglycemia. More often, measurement of certain hormones and metabolites at the time of hypoglycemia indicates which organs and body systems are responding appropriately and which are functioning abnormally. For example, when the blood glucose is low, hormones which raise the glucose should be rising and insulin secretion should be completely suppressed.
It can also be mistaken for
alcohol intoxication
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The most effective means of preventing further episodes of hypoglycemia depends on the cause.
The risk of further episodes of diabetic hypoglycemia can often (but not always) be reduced by lowering the dose of insulin or other medications, or by more meticulous attention to blood sugar balance during unusual hours, higher levels of exercise, or decreasing alcohol intake.
Many of the inborn errors of metabolism require avoidance or shortening of fasting intervals, or extra carbohydrates. For the more severe disorders, such as type 1 glycogen storage disease, this may be supplied in the form of cornstarch every few hours or by continuous gastric infusion.
Several treatments are used for
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, depending on the exact form and severity. Some forms of congenital hyperinsulinism respond to Major Kicks Rose Gold discount best sale with credit card FMO0Jla
or octreotide . Surgical removal of the overactive part of the pancreas is curative with minimal risk when hyperinsulinism is focal or due to a benign insulin-producing tumor of the pancreas. When congenital hyperinsulinism is diffuse and refractory to medications, near-total pancreatectomy may be the treatment of last resort, but in this condition is less consistently effective and fraught with more complications.
Hypoglycemia due to hormone deficiencies such as hypopituitarism or adrenal insufficiency usually ceases when the appropriate hormone is replaced.
Hypoglycemia due to dumping syndrome and other post-surgical conditions is best dealt with by altering diet. Including fat and protein with carbohydrates may slow digestion and reduce early insulin secretion. Some forms of this respond to treatment with a
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Reactive hypoglycemia with demonstrably low blood glucose levels is most often a predictable nuisance which can be avoided by consuming fat and protein with carbohydrates, by adding morning or afternoon snacks, and reducing alcohol intake.
Idiopathic postprandial syndrome without demonstrably low glucose levels at the time of symptoms can be more of a management challenge. Many people find improvement by changing eating patterns (smaller meals, avoiding excessive sugar, mixed meals rather than carbohydrates by themselves), reducing intake of stimulants such as caffeine , or by making lifestyle changes to reduce stress. See the following section of this article.
Replicated association of axes of variation with myocardial infarction. Each gene that is correlated with one of the nine axes in both phases is plotted, showing the mean difference between individuals with and without AMI (higher expression in AMI producing negative values). The overall relationship of the axes with AMI status is highly replicated, notably showing downregulation of axis 1 and upregulation of axis 5. The difference between the studies in axis 2 is readily explained because this axis is associated with BMI, which is elevated in the replication phase sample.
Evidence that the high expression of genes in axis 5 is only partially explained by neutrophilia is provided by cross-matching of the 1,987 genes associated with axis 5 at the 5% false discovery rate (FDR) with published gene expression profiles of distinct blood types from the Immunological Gene Consortium [
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]. This indicates that 45% of 2,469 genes known to be neutrophil-enriched are associated with axis 5 in this study, and 55% of the axis 5 genes are neutrophil-enriched. The fact that the overlap is only partial suggests that neutrophil abundance is not the only explanation for the differential expression. Similarly, reduced lymphocyte abundance does not solely explain the low axis 1 scores in AMI patients, since only 44% of 1,746 axis 1 genes (at 5% FDR) are known to strongly associate with T-lymphocyte abundance. Furthermore, axes 8 and 9 are also enriched for genes involved in aspects of T-cell signaling, while axis 3 has an excess of genes annotated to B-cell signaling. None of these axes are associated with AMI. These results imply that differential gene expression in AMI patients is partly attributable to elevation of the ratio of neutrophils to lymphocytes, and partly to differential gene expression within these cell types.
To confirm this, we compared genotypic effects on gene expression between AMI and non-AMI samples in the discovery phase. A genome-wide association study measuring the effects of locally acting common polymorphisms on the abundance of each of the 14,343 transcripts was performed. Only the 153 Caucasian samples were included to prevent possible ethnicity-associated influences, and only SNPs with a minor allele frequency greater than 0.1 and located within 250 kb of the probe were assessed, also excluding probes known to contain SNPs to avoid hybridization artifacts [ 25 ]. Local genetic regulation of transcript abundance was detected for 355 probes representing 334 genes at P < 10 -5 , with a q-value FDR of 1%. On average, each lead eSNP (the strongest association at a locus) has a Pearson correlation with the associated transcript of 0.46, with a range from 0.27 to 0.90.
eQTL analyses. (A-C) Plots of significance (NLP) of local eSNPs with a transcript probe located within 250 kb of the SNP, contrasting the full Caucasian sample in the discovery phase with the same sample minus all individuals experiencing an MI. (A) The full range; (B) eSNPs in the range 5 < NLP < 15. Colored points differ between the full and non-AMI samples by at least 0.5 NLP units, red indicating higher significance in the smaller sample, and blue higher significance in the full sample. (C) The same analysis as (B) but missing 39 individuals with the highest axis 5 scores who were not experiencing an MI. Numbers show the number of eSNPs in the red and blue categories across the full range of NLP >3. (D,E) Representative plots of transcript abundance by genotype, colored with respect to MI status (red experiencing an MI, blue no-MI). Lines show the slope of the two classes, indicating an interaction effect in (D) but no interaction effect in (E) .
This result, that AMI reduces the genetic regulation of expression of a subset of genes, could simply be explained if the eSNP effect is predominately observed in lymphocytes and/or monocytes, so is diluted out in the AMI samples where neutrophils are more prevalent. To exclude this explanation, we removed an equivalent number of non-AMI high axis 5 samples from the total discovery phase dataset, and re-performed the eSNP evaluations. As expected, significance was reduced for 183 genes due to the loss of power, but only 36 cases of increased significance below the
< 10
threshold were observed. Consequently, the altered genotype effect is not simply a function of high axis 5 scores, but more often reflects an AMI-specific loss of influence on gene expression. To our knowledge, a study-specific disease-by-genotype interaction effect on local regulation of gene expression has only previously been reported for the effect of
parasite load in infants with malaria in a study conducted in Benin [
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Introducing "iTechnology.am" -- The New Voice of Armenia's Information Technology (IT)
By: Marketwired .
Dec. 7, 2012 01:37 PM
NEW YORK, NY -- (Marketwire) -- 12/07/12 -- Stanford University: "iTechnology.am," the new voice for the Armenian information technology business sector, will make its digital debut at the ArmTech Congress 2012 at Stanford University. The innovative, monthly, digital magazine presents exclusive tech-specific, business-building news and features in an interactive format that is easy and engaging to browse -- and also completely social-media enabled, available in English, Armenian and Russian.
About the IT Industry in Armenia
The debut issue is available on the Web at www.itechnology.am. It is designed for the iPad, iPhone and other mobile devices and offers 9 exclusive features, including:
The publication is available, free of charge, to professionals interested in the development of the information technology (IT) business sector in Armenia and around the world. The publication features content syndicated from CommPRO.biz, the international online hub for integrated marketing communications news and opinion.
For more information, please visit www.iTechnology.am.
About iTechnology.am
Todd Fabacher
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