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NetWellness is a global, community service providing quality, unbiased health information from our partners. NetWellness is commercial-free and does not accept advertising.
Sunday, June 18, 2017
Murphy, MD, FACP, FACE
Associate Professor of Medicine
Department of Medicine
School of Medicine
Case Western Reserve University
Thomas A. Murphy, MD, FACP, FACE, is the director of the Division of Endocrinology. Dr. Murphy received his medical degree from the Washington University School of Medicine in St. Louis, Missouri in 1978 and completed an internship and residency in internal medicine at University Hospitals of Cleveland in 1981. He completed a fellowship in Endocrinology and Metabolism at Case Western Reserve University in 1983 and remained on the faculty at University Hospitals of Cleveland for two years before accepting the position of Director of the Division of Endocrinology at MetroHealth Medical Center in 1985. He is board certified in internal medicine and in the sub-specialty of Endocrinology and Metabolism.
Dr. Murphy is co-chairman of the committee that teaches Endocrinology and Metabolism to the first and second year medical students at the Case Western Reserve University School of Medicine. In addition to organizing the committee, he also lectures to the medical students and leads small group discussions. The quality of his teaching was recognized in 2003, when he received one of the Kaiser-Permanente awards for excellence in teaching from the Case Western Reserve University School of Medicine. He has been named one of "America's Top Physicians" by the Center for the Study of Services in Washington D.C. and is listed on "Best Doctors Incorporated" as one of the best doctor's in America. He was voted one of the top doctors in Cleveland in polls published by both Cleveland magazine and Northern Ohio Live magazine.
Dr. Murphy handles patients with all types of endocrine disease with a special interest in thyroid disease and the hormonal management of trans-sexualism.


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Architectural Graphic Standards: Student Edition, 11th Edition
Architectural Graphic Standards: Student Edition, 11th Edition
Mar 2008
560 pages
Product not available for purchase
DescriptionThe new student edition of the definitive architectural reference
For seventy-five years, Architectural Graphic Standards has been the go-to reference for architects, builders, and engineers. Revised for the first time since 2000, Architectural Graphic Standards, Student Edition gives students their own handy resource.
Carefully abridged from the Eleventh Edition of Architectural Graphic Standards, this Student Edition features the same richly detailed graphics and text that have made Architectural Graphic Standards a classic, but updated and reorganized in a way that is relevant to today's student. Thousands of illustrations and a rich index offer immediate access to hundreds of architectural elements, while the wide variety of topics covered makes this work relevant throughout a student's architecture education and into the early stages of professional practice.
With a wealth of information for the student preparing for professional practice, this new edition:
Covers building standards and practices, materials and systems, and details for every type of project
Follows CSI's Uniformat, a classification system that closely matches an architect's workflow
Features completely updated content with a wide variety of standard architectural details
Offers an ancillary Web site featuring sample curriculums, student exercises, classroom projects, PowerPoint(r) slides, and more
Section 1: Building Elements.
Chapter 1: Element A: Substructure.
Chapter 2: Element B: Shell.
Chapter 3: Element C: Interiors.
Chapter 4: Element D: Services.
Chapter 5: Element E: Equipment and Furnishings.
Chapter 6: Element F: Special Construction and Demolition.
Chapter 7: Element G: Building Sitework.
Section 2: Materials.
Chapter 8: Concrete.
Chapter 9: Masonry.
Chapter 10: Metals.
Chapter 11: Wood.
Section 3: Issues of Contemporary Practice.
Chapter 12: Sustainable Design.
Chapter 13: Inclusive Design.
Chapter 14: Computing Technologies.
Chapter 15: Architectural Research.
- As with Architectural Graphic Standards, Eleventh Edition, the Student Edition is reorganized to follow CSI Uniformat, a classification system that closely follows an architect's workflow
- Completely updated content with over 3000 standard architectural details
- Includes an ancillary website featuring sample curriculums, student exercises, classroom projects, powerpoint slides, and more
"Beautifully designed and resplendent with thousands of clear architectural illustrations, this title is an indispensable resource for all architecture Students, new architects, and libraries supporting architecture programs. Highly recommended." (Choice, December 2008, Vol. 46 No. 04)
- Takes advantage of the redesign and reorganization of Architectural Graphic Standards, 11th Edition, to provide content that is not only up-to-date but relevant to today's student
- Covers building standards and practices, materials and systems, and details and specifications for every basic type of project
- Covers topics relevant to many courses in an architecture curriculum, allowing students to use this book throughout their architecture education and into the beginning stages of professional practice


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Robotic swimmers, self-propelling nanomotors, Max Planck Research Group Peer Fischer, Stuttgart, Germany
16th March 2018, 09:30
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text: The patented Bulk Solids Pump (BSP) feeder line has been specifically designed and engineered to provide gentle, precise feeding of free-flowing pellets, granules, flakes, and friable materials. BSP feeders do not use the usual screws/augers, belts, or vibratory trays to convey the material. They utilize positive displacement action to feed free-flowing materials with high accuracy, offering uniform discharge, consistent volume, and gentle handling. The BSP feeders have vertical rotating discs that create feeding ducts. Material moves smoothly from storage hopper to discharge outlet through a "product lock-up zone," achieving true linear mass flow. With no pockets or screws and only one moving part, these compact feeders are cleaned in seconds, making them ideal for applications with frequent material changes. K-Tron, Pitman, NJ 856-589-0500 www.ktron.com/BSPCoperion K-Tron


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Hi! If this is not the proper forum for such a queston then I am sorry and I'd like to apologize beforehand and hope you don't get too upset at me and my question can be removed by an administrator, or just ignore me
My question is if you have a steam heat pipe that runs from the basement to a top apt, and lets say you don't need heat in the top apt, but do in all the apts below, can you remove the air valve in the top apt and just plug-up the hole, and make a new hole in the pipe in the apt below and put in an air valve there? Will this still work correctly? I mean if the air valve won't act funny because you still have a section of pipe AFTER it that will just be dead. Imagine that the pipe cannot simply be cut at the bottom apt so that now it ENDS there instead of it still going up to the apt on top.
I hope this makes sense. I had to work extra during the night on an emergency and haven't slept yet please bear with me thanks!


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Konami Digital Entertainment, Inc. today announced Rock Revolution, an unprecedented, authentic music-based video game that will re-define the rhythm genre. Brought to market by the company that created the music video game category, with breakthrough titles such as DanceDanceRevolution, Karaoke Revolution, Beatmania and Guitar Freaks, Rock Revolution provides an unmatched rock experience. Breaking new ground with its definitive drum experience, Rock Revolution also gives players a chance to rock out on the bass and lead guitar. Designed by musicians, Rock Revolution will be available with the most realistic drum peripheral on the market at launch for the Xbox 360 and PlayStation 3 computer entertainment system.
"Rock Revolution will be the most innovative and realistic rock game to hit the market, that will provide a quality drum peripheral and music that players will appreciate," said Anthony Crouts, Vice President of Marketing for Konami Digital Entertainment, Inc. "As the originator of music-based games, we are dedicated to bringing fans a truly preeminent music experience. With Rock Revolution, we put the emphasis on the drum kit, delivering an experience unlike any other."
Rock Revolution features an extensive music selection on the game disc, along with a wide variety of downloadable songs available at launch for the Xbox 360 and PlayStation 3 system versions of the game. Additionally, title offers a variety of innovative single-player and multi-player modes.
A unique aspect of the Wii version is the interactive use of the controls with the Wii Remote and Nunchuk for an air-drum and air-guitar experience. Rock out anywhere with the Nintendo DS version, using the stylus for intense rhythm matching sessions.
Rock Revolution is scheduled to launch this Fall for the Xbox 360 video game and entertainment system from Microsoft, PlayStation 3 system and the Wii and DS video game systems from Nintendo. For more information, please visit www.konami.com.
About Konami
Konami is a leading developer, publisher and manufacturer of electronic entertainment properties. Konami's titles include the popular franchises Metal Gear Solid, Silent Hill, DanceDanceRevolution and Castlevania, among other top sellers. The latest information about Konami can be found on the Web at www.konami.com. Konami Corporation is a publicly traded company based in Tokyo, Japan with subsidiary offices, Konami Digital Entertainment Co., Ltd. in Tokyo, Japan, Konami Digital Entertainment, Inc. in the United States and Konami Digital Entertainment GmbH in Frankfurt, Germany. Konami Corporation is traded in the United States on the New York Stock Exchange under the ticker symbol KNM. Details of the products published by Konami can be found at www.konami.com.


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Stockton, CA
Paula Joan Van Laar
May 13, 1954 - February 11, 2013
Paula Joan (Cox) Van Laar, age 58, passed away unexpectedly the morning of Feb-ruary 11th due to
arising from her battle with polycystic kidney disease (PKD). Paula was born in San Bernadino, California on May 13, 1954, to Lawrence Cox and Cora Sue McCarty.
She grew up on a small farm in Merced, California where she
attended local schools. She was a member of the Merced High School class of 1972. She attended college in Tulsa, Oklahoma on a rodeo scholarship. She obtained a degree in real estate and pursued a in real estate sales and
development while in Oklahoma. She developed strong family bonds with her in-laws James and Cloda Rae Ready, while raising her daughter Anissa. She was very proud of her Native American Indian roots of Cherokee ancestry.
She returned to Merced in 1985 and worked for the City of Merced Planning Department, and as a bookkeeper/controller, and real
estate sales. She was involved in many local philanthropic activities and belonged to the North Merced Rotary Club. She was involved with Merced Community Medical Center Foundation, and the Court Appointed Special Advocates (CASA) program. She served
several years as the Rotary
District 5220 Sergeant at Arms for District functions, and developed lasting friendships within the
Rotary family.
In 1992, she married the love of her life and soul-mate, Lammert, with whom she shared a wonderful, romantic love affair for the ages. She was very proud and was her family's greatest cheerleader. She and Lammert relocated to Stockton in 1996. She is an alumnus of Leadership Stockton Class of 1997-1998. She was a member of North Stockton Rotary, and continued in real estate sales until retiring in 2005.
She was a very active, take-charge person, and put all her
effort into every endeavor. She loved to compete with the guys in Fantasy Football Leagues. She loved playing golf and working golf tournament fundraisers. She was a consummate entertainer, a
master conversationalist who could make anyone feel at home. She was known for her legendary Christmas Open House celebrations at her Stockton home, everything carried out with fashion and flair. She was a tremendously
talented gourmet cook, tweaking recipes with her own personal
touches that would rival any
professional chef. Her cookbook collection numbers in the hundreds. She enjoyed gardening and interior/exterior design, and taught modeling and etiquette. She loved camping, hunting and fishing and just being outdoors.
She had a certain energy about her that would become evident at the moment she entered a room. Everything was bigger and better with her around. She encouraged spur of the moment activities and was a superb party planner. She shared an enthusiasm for wine and wine making with friends in Fiddletown, while producing award winning wines under the private
label, Paulmert Cellars, and
always cooked for the "work crew".
She leaves behind her husband Lammert, daughter Anissa Johnson, grandsons Jacob Johnson, Anthony Blair and Rodney Burger Jr. and granddaughter Aiden
Burger. She is also survived by her brother Bill (William) and sister Charley (Stephanie), and mother Cora Sue. She was predeceased by her father Lawrence and
brother Michael, both having
succumbed to the effects of PKD.
A memorial celebration of Paula's life will be held at the Stockton Golf and Country Club (dress code, no denim) on March 1, 2013 at 1pm. In lieu of flowers,
donations in Paula's name may be sent to the Polycystic Kidney Foundation (www.pkdcure.org), or the Child Abuse Prevention
Council of San Joaquin County (www.nochildabuse.org), or a charity of your choice.
Please sign guestbook at www. frisbiewarrencarrollmortuary.com.


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There's several reasons why this process takes so long, and why the products we've seen coming from the new Google-owned Motorola are essentially the same as they've always been - including non-vanilla Android. First, a hardware company like Motorola has a product pipeline that you can't just kill. Motorola's sales may not have been doing well, but declining sales is still better than no sales at all. Especially in the mobile industry, a product has to comply with boatloads of standards, laws, and regulations - and that requires lots of testing by both the manufacturer itself, as well as agencies and institutions all over the world. And remember - every country has its own rules.
This means that even if Google started designing Motorola phones right away after acquiring Motorola, these phones would simply not be ready now. So, instead, we're looking at the same old Motorola stuff the public had already grown tired of - including Motoblur.
However, the chances that Google started designing phones right away are slim. Motorola is a large company, and so is Google - the process of integrating the two isn't easy. I obviously have zero experience with something like that, but common sense can go a long way here. Common sense also states that it's probably a good idea to finish this integration process first, before starting to work on completely new products.
During the Google earnings call, CFO Patrick Pichette stated just that:
Remember that we inherited an entire product pipeline where hardware business cycles are typically 12 to 18 months.
I'm actually incredibly curious to see where Google will take Motorola. If my Nexus 7 - built by Asus, but Google has its hand in it - is anything to go by as to what to expect from Google's own hardware division, we'll be in for some great stuff. I don't want Samsung to remain as domineering as it is now, so hopefully, Google's Motorola can do something about that.


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Original URL: https://www.theregister.co.uk/2006/01/17/cingular_sues_over_customer_records/
Cingular accuses two firms of stealing customer records
Hello. Is it me you are looking for?
Posted in Policy, 17th January 2006 15:15 GMT
Cingular Wireless won a temporary restraining order on Friday against two companies which it accuses of selling illegally-obtained customer records over the web.
The two companies, DataFind Solutions and 1st Source Information Solutions, are already the subject of a civil suit from Cingular.
But embarrassment for the cellphone operator soared last week on the back of a CBS News item "which condemned the wireless industry at large for not protecting customer call records", RCR Wireless News reports.
According to Cingular, Data Find "previously owned and operated several websites that advertise the sale of phone records, including http://locatecell.com/ and http://celltolls.com/, and that 1st Source Information Specialists, Inc. currently owns and operates these websites".
Now for a trenchant quote from Joaquin Carbonell, Cingular's top in-house lawyer:
"Cingular will not tolerate the theft of customer records We plan to continue fighting cell phone record theft on a number of fronts, including working with law enforcement and policymakers to crack down on websites that offer cell phone records for sale."
As we reported last week, dozens of data brokers in the US make a business from selling call records - sometimes obtained from phone company insiders or by deception - for about $100 per account per month. The chief market is private investigators, but an investigation by the Chicago Sun Times suggests the information is available to anyone who's prepared to pay. Few or no checks are applied over the identity of the person requesting information. ®


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Celebrating illustration, design, cartoon and comic art of the mid-20th century.
Monday, June 26, 2006
Illustrating Water
On his blog, Illustration Art, David Apatoff recently presented a two-part post on painting water, focusing in the second half on illustrator Stanley Meltzoff, who goes so far as to actually paint under water!
I was intrigued by those two posts and thought it might be fun this week to look at how a variety of illustrators from the 50's dealt with water, both above and below the waves, starting with these two monochromatic treatments by two relatively unknown - though certainly accomplished - illustrators from Argosy magazine.
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Fabric Care
Machine Washing
This article can be machine washed. Do not exceed the wash temperature shown on the icon.
Delicate Washing
This article can be machine washed on a delicate wash cycle. Do not exceed the wash temperature shown on the icon.
Hand Washing
This article is only suitable for hand washing.
This article can be ironed. The dots on the iron represent the ironing temperature. 1 dot means the article needs to be ironed on a cool temperature (100Cº), 2 dots means the article needs to be ironed on a warm temperature (150Cº) and 3 dots means the article can be ironed on a hot temperature (200Cº)
No Ironing
This article must not be ironed.
Dry Cleaning
This article can be dry cleaned. The letters in the circle provides information regarding the cleaning fluids that may be used.
No Dry Cleaning
This article must NOT be dry cleaned.
No Bleaching
This article must NOT be bleached.
Tumble Drying
This article can be tumble dried. The dots represent the heat setting that must be used. 1 dot means a reduced heat, 2 dots means a normal heat.
No Tumble Drying
This article must NOT be tumble dried.
- always read and follow care instructions on the label.
- use a lingerie wash bag when washing underwear in a machine.
- hand wash any bra with an underwire - wires can be bent, damaged or broken or may even come out in the washing machine.
- wash lingerie frequently to keep it in tip-top condition - perspiration, perfumes and body lotions can all mark the fabric and regular washing minimises the risk.
- when hand washing always choose a washing liquid or powder specially made for delicate fabrics - make sure all powder is dissolved before putting garments in the water.
- don't leave lingerie to soak for more than five minutes.
- wash darker colours separately.
- don't exceed the recommended washing temperature - remember the latest products wash just as well at 40ºC, often even at 30ºC.
- dry lingerie away from direct heat such as radiators, fires and even hot sunshine otherwise they may discolour, especially whites/light colurs.
- avoid catching delicate fabrics and laces with clothes pegs - use the washing label to peg bras and pants to the line.
- do not tumble dry lingerie unless the care label provides specific instructions.
Swimwear needs extra special care to enjoy a longer life - especially if used regularly in a chlorinated pool. All the washing advice for lingerie applies, but swimwear often faces greater punishment at the beach or pool.
- always rinse swimwear in fresh, tepid water as soon as possible - immediately is best - after every wear.
- follow this, again as soon as possible, with a hand wash in a gentle detergent and a very thorough rinse.
- never leave your swimwear wrapped up in a damp towel!
- if you want your swimsuit or bikini to dry extra-fast, roll it gently in a dry towel to soak up excess water, then hang away from direct heat.
- never tumble dry or iron swimwear.
- remember pool chemicals, perfumes, cosmetics and sun oils and creams could damage and discolour swimwear, especially designs using elastane.
- try the peg-the-label trick to avoid catching the fabric - or hang your swimwear to dry on a clothes hanger for maximum airing.


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I used to be an avid vintage shopper, scouring markets and vintage or second hand shops for treasures. I still love vintage but sadly, these days I'm usually never free to go shopping for it. Most shops I'd like a good rummage around are closed by the time I finish up for the day and weekends are almost never free. And let's face it - vintage shopping takes a lot of time. In recent years all my clothes shopping migrated online, including for vintage.
Every so often I peruse that great, open-all-hours vintage market place on the internet for bargains - Ebay. And I know I'm not alone judging from the bids I've lost to others and the number of watchers on items that catch my eye. In the past I've had some great successes buying vintage on Ebay (as well as spectacular failures). Focusing on the good I have some lovely Victorian and Edwardian pieces that were actually quite inexpensive. This lace embellished Victorian jacket, the gold leather flapper shoes and this ivory cream opera cape made out of a piano shawl are some of my favourite Ebay buys.
I've been using Ebay lately to look for vintage furniture for the flat but the last couple of evenings attention deficit drove me to the vintage women's clothing section. After a long spell perusing what was on offer, I have to say I felt it was harder to find quality and genuine items with reasonable start bids. Vintage price inflation has seeped into the start prices and some irritating claims and tricks are being tried by sellers to sell their wares, not all of them qualifying as vintage.
Now I take vintage to mean clothing that was genuinely made in a particular era, and we are talking eras spanning from a time starting thirty or forty years back, clothes that have some genuine fashion history behind them. But judging from what sometimes gets listed in the vintage clothing section I do wonder if the average Ebay vintage seller is familiar with this concept!
Some practises by sellers that kept cropping up repeatedly really did start to grate after a while and I thought they deserved calling out. So here they are - my pet peeves when hunting for vintage items on Ebay. Vintage sellers take note!
- Sellers listing modern second hand clothing in the vintage section tagged as "vintage style" - please cease and desist. You are taking up valuable screen space on my search list which could be filled with real vintage items. I don't want something that is vintage style. I want the real deal. Ebay can't you set up a separate category for "vintage style" items on their own? I swear it would be ten times the size of the real vintage section. Anyone know how to set up an Ebay search to avoid this phrase??
- Modern clothing posing as vintage - a secondhand item from Topshop, H&M, Karen Millen, New Look, Zara, and Miss Selfridge does not a vintage garment make. Please also read point one.
- They may look vintage-y but unless it was manufactured in the 1970s (or 80s at a push) or earlier your "vintage" Monsoon or Laura Ashley is usually just last season's or several seasons old Monsoon or Laura Ashley.
- Sellers using "Gatsby" or "Downtown Abbey" or whatever title of period dress movie or TV series which happens to be flavour of the month. It does not make your garment more desirable by comparing it to the costumes in a movie or screen show with a million dollar costume budget.
- Sellers asking four figure sums for vintage garments. I have two not very polite words to say to you. I can get me some runway pieces by top designers for that type of money that don't have moth holes, rips, tears, missing bits or a musty, moth balled smell and hundred year old perspiration marks. That old adage of flaws and imperfections being part of the charm of vintage clothing begins to wear off at around the £100 mark. Over £1000 I am more likely to think that you are a money launderer than entertain any notion of bidding on your overpriced item which you probably picked up for buttons.
- Posting an average UK size instead of posting accurate measurements of the garment. There is no average UK size people! A UK 8 in one store can be a UK 6 in another and a UK 12 in yet another. And it has probably changed since you last hit the change rooms on the high street. I'm tired of typing in the same request for chest, waist and shoulder measurements for your garments. Don't be so lazy and post some measurements! Or I won't bid!
- Getting your periods wrong. I've seen some pretty outlandish claims as to what constitutes a 20s flapper dress, what is Victorian, what is Edwardian, the list goes on. And then there is some blatant cover your ass type banding like "50s - 70s dress" - that's a time span of three decades! A very long time in fashion! Please do some research and at least try to get it right or admit that you just don't know.
Vintage Victorian riding jacket: Ebay


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Stay informed
Find architectural drawings, a phasing plan, budget and bidding information and much more on the library's Web site: Renovation home page.
Enjoy convenience, service and the best seat in the house
Drive up to the new materials return box in the parking lot and get back to your busy day. Customer service and self-checkout technology greet you throughout the building. Grab a comfortable chair by a sunny window or our welcoming atrium, or get down to work in the lobby Internet café. From the latest buzzed-about indie release to family-friendly flicks, browse for movies and music on the first floor. Our reading commons will be your new favorite "third place" to relax with something good to read or enjoy an informal library program.
Get to work
Fire up your mobile gear and settle into an "office-away-from-home" work pod, then set up a meeting with colleagues in one of our business center mediascape rooms. Explore your imagination, craft the perfect presentation, or launch your job search in our technology center. Learn, then create something awesome in the media lab and makerspace.
Experience fun and interactive learning
Enter a world of interactive fun and learning designed especially for children. From kid-sized furniture and shelving to a kid-friendly media lab, this colorful, comfortable environment will become a family-favorite community destination. Technology classes, educational experiences, interactive exhibits and entertainment kids will love.
Bring your friends
Speaking of classes, entertainment and great experiences – we'll be offering all of that for teens, young adults and adults, too. Teens – grab a booth and study with your friends or show off your competitive side in the gaming room. Our refurnished public meeting rooms will be back in service and with improved acoustics, your informational lecture, piano recital, or informal crafting session will come through crystal clear. Smart room meeting space allows you to broadcast and record a webinar while making a truly interactive presentation. Enjoy collaborative space throughout the library, for your family, your classmates, your club or organization.
Preserve a community asset
The library building is not being expanded, but it is being improved and updated to preserve this community asset well into the future. HVAC, plumbing, lighting and fire protection systems and the elevator will be replaced or repaired. Updated systems mean a safer, more comfortable, energy-and-cost efficient space.


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The mysterious 10-inch HTC tablet we saw last week got quite a bit of attention, but the latest rumor going around on the web is that HTC is working on a 7-inch successor to the HTC Flyer. The HTC Flyer 2 is said to feature a 28nm Snapdragon S4 chip, Android 4.1, 3 megapixel camera on the back, 1 megapixel front-facing camera and a 7.1mm thin anodized aluminum body similar to the HTC One S. The 7-inch display is expected to feature a resolution of 1280×768 pixels, giving the HTC Flyer 2 a 213.25 ppi – much higher than the 170 ppi of the original Flyer.
There's no word as to when the HTC Flyer 2 will be unveiled, but the general consensus is that HTC will position this device to compete on price with the new Kindle Fire and the Nexus 7. If that's the case, we doubt HTC will include its Scribe active pen technology, but that's pure speculation on our part.
Do you think HTC can deliver a 7-inch tablet at the right price to compete with Google and Amazon?


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SAN DIMAS >> Three parked cars were destroyed in an arson fire early Wednesday, officials said.
Officials responded to a vehicle fire just after 3:40 a.m. in the parking lot of a business park in the 600 block of W. Covina Boulevard, Los Angeles County sheriff's Sgt. Rebecca Rodriquez said.
All three vehicles were owned by the same person, she added.
One of cars appeared to have caught fire first, before the flames spread to the other two, the sergeant said.
The hood of the first vehicle that caught fire had been stolen, Rodriquez said.
It was unclear if the car had been set afire intentionally, or if it had caught fire while someone was attempting to steal parts from it.
The destroyed cars were valued at about $10,000 in all, she added.
Deputies turned the investigation over to the investigators from the Sheriff's Arson-Explosives Detail.


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When it comes to quality thumper percussion massagers are the nation's leading back massagers. There are lots of inexpensive cheapo models on the market that are underpowered and suffer from poor design. The Thumper Mini Pro 2 by comparison integrates professional strength direct drive technology which provides an unparalleled massage experience. The thumper mini is also specially designed to eliminate as much as 95% transfer vibration or "kickback" through the handle.
As a special limited time offer we are giving away free shipping on all thumper massagers.
Posted under massager, thumper
This post was written by David White on January 31, 2009


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Telstra VoIP trial kicks off
Telstra has commissioned and is testing its next generation Voice over IP platform, the telco said in a media release today.
Around 200 people in Melbourne are using the Telstra Softswitch Platform, which enables VoIP-based multiple telephone line capability and call control features on their existing broadband service.
Telstra said it would continue to test the quality of calls and ease of configuring various services of interest to customers.
Lucent Technologies is the main provider of the technology.
NSW roads contract
Fujitsu Australia has been retained by the NSW Roads and Traffic Authority to manage its data centre and related information technology operations.
A media release said Fujitsu had provided outsourcing services to the RTA since 1997.
The RTA employs about 6900 staff at more than 180 offices, including 129 motor registries.
It has given Fujitsu a three-year contract from July 2005, after a transition period. The RTA has options to extend the new contract for four more years.
Email security
Sophos Anti-Virus, HP and Commander have teamed up in Australia to deliver low-cost email security that can protect businesses from viruses, worms and spam, and enforce corporate policy.
A media release said Sophos PureMessage integrated anti-spam and anti-virus software was used along with HP ProLiant Servers running Red Hat Enterprise Linux.
Commander provides the customisation and systems integration services.
Traffic shaping technology
Email security provider MessageLabs has enhanced its global anti-spam infrastructure to reduce spam volumes.
A media release said MessageLabs was deploying Symantec's latest traffic shaping technology in its 14 data centres, allowing all MessageLabs clients to benefit from the technology.
Symantec's technology shapes email traffic at the TCP level, decreasing the volume of inbound spam even as spammers increase the volume.
It identifies abusive senders and throttles their connections back at the network level, ultimately forcing the originator of the messages to alter the rate at which packets are placed on the network.


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Six years ago, serial entrepreneur Kieran O'Neill launched a small start-up business that combined technology and fashion to offer men a personal styling service. This week, that business has received $22m (£16.7m) in funding, bringing its total investment to more than $40m (£30.4m).
Entries are now open for the Drapers Digital Awards - recognising the best of the best in ecommerce across the fashion industry in the UK and Ireland.
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Tech entrepreneur turned fashion CEO Ulric Jerome was the ideal choice to help transform an independent retailer into an innovative, industry-leading international digital empire.
Drapers Footwear Awards 19 will recognise and celebrate the footwear's very best from across the UK and Ireland.
We have 18 exciting categories up for contest, including International Footwear Business of the Year and Best Sustainable Initiative of the Year.
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Maison Labiche co-founder Marie Welté elevates basics with embroidery
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As it prepares to launch new stores, Drapers talks to Ghost London's creative director Sameera Azeem about breathing new life into the womenswear brand.
Taking place on 29 November 2018, the Drapers Awards recognises and celebrates the best of the best in the fashion sector.
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By Emily Sutherland
The European Union's competition commissioner has said she is 'looking into' Amazon's use of data from sellers on its site amid concerns the tech giant uses the information to boost its own sales.
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>This listing is for Wholesale Buyers. For the Retail listing, please visit the Earrings section of our website.
> Opaque turquoise glass hangs from delicate antiqued silver teardrops.
> Handmade, sterling silver ear wires.
> Approximately 2.5 inches in length.
>Product Code: EBST
>Retail Price: $26.00
>Please enter your custom store code at checkout to receive wholesale pricing.
>Sales, discounts and coupon codes are not applicable to wholesale purchases.
>Wholesale orders are shipped within 1-2 weeks of order being received.
>All orders are sent via USPS Priority Mail and arrive within 2-3 days of shipment. You will receive an email notification when your order has shipped, complete with tracking information.
>For new Wholesale accounts, please email us at bellwetherblonde [!at] gmail.com.
Payments are gratefully accepted through Paypal and Direct Checkout.
Purchases of multiple items will be packaged together unless requested otherwise.
Retail orders will be sent out within 3-5 business days of receiving payment unless otherwise noted.
All orders ship from the United States and will be shipped to the address on your Etsy account. Please make note of any special shipping requests in the Notes to Seller section at check out.
Orders are shipped via USPS First Class Mail with an estimated shipping time of 2-5 days. Orders may be upgraded to USPS Priority Mail for an estimated shipping time of 1-3 days.
Orders are shipped via First Class Mail with an estimated shipping time of 2-6 weeks depending on location. It is the buyers responsibility to to pay for any separate customs fees, duty, or import taxes. Please contact your local customs office for information on any additional fees.
But please contact me if you have any problems with your order.
If you are not satisfied with your purchase please let me know and I will do my best to resolve the issue. No refunds are granted with exception of goods damaged in shipping. -Thank You-
For wholesale information, please email email@example.com.


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The relationship between Republicans and Democrats is often framed as an entrenched stalemate, with legislators of each party diametrically opposed on everything from the environment to taxes.
But to hear Jim Gray tell it, the major parties are two sides of the same coin, both content to spend too much and encroach too far on citizen privacy.
At a forum hosted by Fort Lewis College, and later while meeting with The Durango Herald editorial board, the Libertarian Partys vice-presidential candidate laid out an impassioned, and radically different, vision for how the United States should be governed.
Gray portrayed the Libertarian ticket as the most-qualified on this years ballot. He described his running mate, former New Mexico Gov. Gary Johnson, as a man of courage and principle who grew a modest handyman business into one of the states largest construction firms, Big J Enterprises, with more than 1,000 employees.
Gray also credited Johnson for leaving New Mexico with a $1 billion budget surplus when his second term ended in 2003.
He chided Vice President Joe Biden and Rep. Paul Ryan for lacking job experience outside government, although Gray himself spent much of his career in the public sector. After graduating from University of Southern California law school in 1971, Gray served as Judge Advocate in the U.S. Navys JAG Corps and later for 20 years as an Orange County Superior Court judge until retiring in 2009.
High on Grays agenda was a sweeping audit of the federal government by private contractors, using generally accepted accounting principles.
Every agency would be subject to show the people what value they are getting or not getting, he said.
Gray was keen to break the stereotype that Libertarians are a one-issue party focused on decriminalizing marijuana. He did, however, unabashedly label current drug policy a failure, second in U.S. history only to slavery.
Gray argued that regulating and taxing marijuana and potentially other drugs would remove them from the black market, where sales line the pocket of violent cartels and incarcerations feed the prison-industrial complex. Prohibition in the 1920s did nothing to quell American demand for alcohol, he said, and the lack of oversight permitted sellers to contaminate their products with toxic additives.
Gray took pride in rocking the political boat and confronting tough issues the two main parties have traditionally shied away from. For example, he and Johnson oppose the Patriot Act and all forms of surveillance without a warrant, and support repealing the death penalty, closing the Navy base in Guantanamo Bay, Cuba, and withdrawing U.S. troops from Afghanistan immediately. He criticized Paul Ryans House budget for not balancing for 28 years, and said the government, as a neutral arbiter, has no right to ban gay marriage or restrict contraceptive access on religious grounds.
Other Libertarian planks include:
Replace the income tax with a consumption tax.
Abolish the Department of Education, expand school vouchers and give individual districts leeway to customize curriculum.
Create private health-savings accounts and catastrophic insurance coverage for most people, with government-funded health clinics for the poor.
Raise the Social Security eligibility age and transition to a privatized system for younger Americans; auction off Bureau of Land Management holdings and funnel proceeds into Social Security fund.
Liberalize visas for foreign workers, with background checks to weed out those with criminal records.


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The Premier League champions were unfortunate to be eliminated from the competition at the group stage last season after amassing 10 points, but went out of this season's iteration with a whimper - picking up just three points and finishing bottom of the group.
Tuesday night's defeat to Dortmund left Hart furious, with the goalkeeper upset with his side's reaction to going a goal behind in the second half.
When asked if City have let themselves down in Europe, Hart told Sky Sports: "Yeah, of course we have. We're out of Europe, we're not even in the Europa League so that's fair to say.
"There was a hunger to win, like I say we've let ourselves down in this tournament but there was a hunger to win.
"If that meant the Europa League then great, but we've got bigger issues that that, we need to be winning playing [against] a weakened team tonight.
"Congratulations to Borussia and Real Madrid I thought they were fantastic, but we should be fighting, definitely fighting last day to be in the competition and we weren't.
|Manchester City are 11/1 with bet365 to beat Man Utd 2-0
"[Intensity] was there and then they scored, and it disappeared which is a shame to be honest because we're a side who can come from behind. We've proved it in both competitions so it was disappointing."
The England No.1 dismissed the notion that the defeat would affect City's performance against Manchester United on Sunday, and is itching to set the record straight in Europe next season already.
He added: "We should have been in that position [to qualify] and we weren't, we only have ourselves to blame, that's it.
"We've disappointed in Europe and been fantastic in the league, we've been consistent and won so I don't think there's any worries about that but we do need to address it for getting in the Champions League again, winning the league and hopefully we'll be able to deal with it next year."


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Kaley Cuoco Grabs Coffee for Two After Date with Henry Cavill
Kaley Cuoco starts her Independence Day off by grabbing coffee for two at a local Starbucks shop on Thursday (July 4) in Sherman Oaks, Calif.
The 27-year-old Big Bang Theory actress took her relationship with new boyfriend Henry Cavill public by holding hands while grocery shopping together.
PHOTOS: Check out the latest pics of Kaley Cuoco
If you haven't seen it yet, make sure to go check out Henry's latest movie Man of Steel, in theaters now!
FYI: Kaley is wearing Dana Rebecca Designs earrings.
10+ pictures inside of Kaley Cuoco getting her morning coffee fix…


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Catherine Tate doesn't have any movies playing in theaters.
If you feel like heading out, check out other movies in theaters.
Monte Carlo
Gulliver's Travels
Love and Other Disasters
Scenes of a Sexual Nature
Starter for 10
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
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This week the Gene Siskel Film Center begins a 14-part retrospective of street-level, purely American poetic-realist cinema spanning five different decades and too many different sensibilities to fit into any one box.
First up in the program called "The American New Wave" is a 1957 landmark of the documentary/narrative hybrid: "On the Bowery," Lionel Rogosin's 65-minute gem, shot in the New York neighborhood's lower depths. School of the Art Institute professor Bruce Jenkins will provide some context for this remarkable work, as he begins his Tuesday lecture series.
Filmmaker Rogosin was not the first to bend the documentary form to fit a prescribed narrative structure (Robert Flaherty's "Nanook of the North," among others, beat him to the punch by a generation). But in 1956, when Rogosin and his colleagues took their camera down to the lowest of the low-rent Skid Row district in Manhattan, they came back with a startling and influential hybrid.
"On the Bowery" offers some of the most indelible faces in an American docudrama, faces ravaged by alcohol and poverty, creased by defeat and self-deception, surrounded by a New York City that does not care. Yet no one on screen asks for pity. The lightly inscribed plot concerns Ray, played by Ray Salyer, who turned down Hollywood offers after the film's initial release only to disappear soon afterward. He's back in town after working on the railroad. His drinking companion, Gorman (Gorman Hendricks), is both friend and exploiter.
As Rogosin follows these two in and out of saloons and their respective ways of making a few bucks, the images captured by the camera — of mid-century Bowery life and its dogged inhabitants — reveal clear links to postwar neorealism. The streets and poverty could have come from "Germany Year Zero," Roberto Rossellini's masterwork. But this is an all-American movie, not without pretensions (composer Charles Mills' use of the harpsichord seems off) but full of harsh beauty.
"Nuthin' gained, nuthin' lost," says one man to another as they exit the Bowery tavern in search of enough money to get them through another day. Near the end, Ray swears he'll quit drinking yet again and wonders if he should hop a freight to Chicago for his "last stand." This film exerted a strong grip on the imaginations of everyone from John Cassavetes to Martin Scorsese to Kent Mackenzie, whose 1961 film "The Exiles," no less vivid, is the LA bookend to this New York story. As for Cassavetes, he responded to the freedom and grit of "On the Bowery" with his own 1959 picture "Shadows," which plays next week at the Film Center.
"On the Bowery" plays at 6 p.m. Friday and Tuesday at the Siskel Film Center, 164 N. State St. Running time: 1:15. Showing with the 1948 James Agee/Helen Levitt/Janice Loebshort "In the Street."


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European Comfort-Fit Wedding Ring
In Stock | STYLE: EUCF135
Ships in 6-8 Business Days
This classy and elegant 14 karat Yellow gold 7.5mm wedding band features a slightly flat surface and Comfort-Fit on the inside for unforgettable comfort. Benchmark has been manufacturing designer wedding rings in Gold, Platinum and Palladium for over 40 years. Made in the USA using 100% recycled materials you can feel good about choosing Benchmark wedding bands.... *Prices are subject to change based on fluctuations in metal prices and currencies
General Details:
Manufacturing beautiful bridal jewelry for over 40 years, Benchmark utilizes the finest skilled craftsmen and state of the art technology to create beautiful wedding rings in gold, palladium, and platinum. Proudly manufactured in the U.S.A., each Benchmark ring is carefully crafted and undergoes a 6 step quality control process to ensure that your wedding ring will last for generations.
Do you have questions about European Comfort-Fit Wedding Ring?
Please send us a message and our staff will be happy to help you with whatever questions you may have.


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Roger Federer checked in with his fans through an e-mail newsletter (he's having a good time in New York, and he got great birthday presents from his fans, thankyouverymuch), and it reminded me of this shirt that's for sale at RogerFedererShop.com. It's a good shirt to wear if you're cheering on Roger at the U.S. Open this week.
Proceeds from this limited-edition shirt benefit the Roger Federer foundation.


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Earn MYER one points when you shop online with Myer.
More information
Product InfoDaniel Wellington 28mm Petite Melrose. Rose Gold case and rose gold stainless steel metal mesh band with a Black Dial.
- Gender: Women
Our No Regrets Returns Policy is all about making it easier for you to experiment and try something new, so we've made the process of returning purchases that are 'not quite right' as easy as possible.
You can return and exchange items at one of our 60+ store locations, or return items to us by mail.


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A Tank in a Glider. How the hell do you fit a Tank in a Glider, and then fly it hundreds of miles, land it, and then fight from it? It seems ridiculous, but this really did happen during the latter stages of the Second World War.
Although Britain was woefully slow in developing Airborne Forces, one aspect in which she was far in advance of her allies and enemies was that of developing means of transporting tanks into battle by air. Obviously it would have been impossible to carry anything like Sherman or Churchill by air, but it was found that the Tetrarch – a small light tank – could fit inside a General Aircraft Hamilcar Glider. Hamilcars were the largest glider used by British Forces during the war, and flew in action in Normandy, at Arnhem and during the Rhine Crossing. Flying a huge Glider loaded with a light tank was an impressive feat for the men of the Glider Pilot Regiment, who upon landing became infantry in their own right.
Flint gives us an impressive overview of the development of both the Tetrarch and Locust, and also of the Hamilcar glider that carried them into battle. Not only are we informed about the machines, but also the men and the units that fought with them. It was indeed a surprise to me to learn that once the ground forces linked up with the airborne recce units the airborne men swapped their light tanks for heavier Churchill tanks, which gave the Airborne Division much more firepower and enabled it to act as a regular infantry Division, such as in the advance to the Seine in the summer of 1944 and from the Rhine Crossing to the Elbe in 1945.
One aspect I am particularly interested in is the lack of any serious Armour in the 1st Airborne Division that landed at Arnhem. As Flint has shown, this was more by accident than by design. It would be reasonable to suggest that while Tetrarchs or Locusts might not have fared too well against Mark IVs, Tigers of Panthers later in the battle, in the early advances to the Bridge tanks might have fared better in the infamous ambush than lightly armed Jeeps. Even better, a troop of tanks in front of each Battalion heading for the Bridge would have been most effective. The 1st Airborne Recce commander, Major Freddie Gough, suggested that some of 6th Airborne's tanks could have been used at Arnhem, but this suggestion was not taken up. This more than fits in with the impression that the Arnhem operation was badly planned and opportunities were missed.
Keith Flint has made valuable use of some original documents, particularly from the Tank Museum at Bovington and the Museum of Army Flying at Middle Wallop. This is the kind of history I like – original research, on a new subject, that focuses on both the men and the machines. This is a significant addition to both the armoured and airborne historiographies of the Second World War.
Airborne Armour is published by Helion Press


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Enter Our Photo Contest »
It's time to show off your garden filled with American Meadows products!
Show meShowing plants & seeds that grow in my area:
With its pleasant scent and delicate flowers, Lavender has grown into a much-loved perennial in garden beds throughout the country. Choose varieties that will work for your climate and growing conditions and you'll be rewarded with long-lasting blooms on mature, mounding plants. Spanish lavenders with their two-toned blooms are perfect for containers, while some aromatic English lavenders can survive a tough northern winter. French lavenders, with their showy foliage, add just the right touch of grace to ornamental flower gardens. Lavenders do prefer full sun, low humidity, and gritty soil, but many can - and do - grow them with ease.
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"I have a dream that my four little children will one day live in a nation where they will not be judged by the color of their skin but by the content of their character."
This sentence spoken by the Rev. Martin Luther King Jr. has been quoted countless times as expressing one of America's bedrock values, its language almost sounding like a constitutional amendment on equality.
Yet today, 50 years after King shared this vision during his most famous speech, there is considerable disagreement over what it means.
The quote is used to support opposing views on politics, affirmative action and programs intended to help the disadvantaged. Just as the words of the nation's founders are parsed for modern meanings on guns and abortion, so are King's words used in debates over the proper place of race in America.
As we mark the King holiday, what might he ask of us in a time when both the president and a disproportionate number of people in poverty are black? Would King have wanted us to completely ignore race in a "color-blind" society? To consider race as one of many factors about a person? And how do we discern character?
For at least two of King's children, the future envisioned by the father has yet to arrive.
"I don't think we can ignore race," says Martin Luther King III.
"What my father is asking is to create the climate where every American can realize his or her dreams," he says. "Now what does that mean when you have 50 million people living in poverty?"
Bernice King doubts her father would seek to ignore differences.
"When he talked about the beloved community, he talked about everyone bringing their gifts, their talents, their cultural experiences," she says. "We live in a society where we may have differences, of course, but we learn to celebrate these differences."
The meaning of King's monumental quote is more complex today than in 1963 because "the unconscious signals have changed," says the historian Taylor Branch, author of the acclaimed trilogy "America in the King Years."
Fifty years ago, bigotry was widely accepted. Today, Branch says, even though prejudice is widely denounced, many people unconsciously pre-judge others.
"Unfortunately race in American history has been one area in which Americans kid themselves and pretend to be fair-minded when they really are not," says Branch, whose new book is "The King Years: Historic Moments in the Civil Rights Movement."
Branch believes that today, King would ask people of all backgrounds - not just whites - to deepen their patriotism by leaving their comfort zones, reaching across barriers and learning about different people.
"To remember that we all have to stretch ourselves to build the ties that bind a democracy, which really is the source of our strength," Branch says.
- MLK III "honored" Obama will take oath on father's Bible
- Marthin Luther King Jr. balcony opens to public for 1st time in years
- Complete coverage: President Obama's Second Inauguration
Bernice King says her father is asking us "to get to a place - we're obviously not there - but to get to a place where the first thing that we utilize as a measurement is not someone's external designation, but it really is trying to look beyond that into the substance of a person in making certain decisions, to rid ourselves of those kinds of prejudices and biases that we often bring to decisions that we make."
That takes a lot of "psychological work," she says, adding, "He's really challenging us."
For many conservatives, the modern meaning of King's quote is clear: Special consideration for one racial or ethnic group is a violation of the dream.
The quote is like the Declaration of Independence, says Roger Clegg, president of the Center for Equal Opportunity, a conservative think tank that studies race and ethnicity. In years past, he says, America may have needed to grow into the words, but today they must be obeyed to the letter.
"The Declaration of Independence says all men are created equal," Clegg says. "Nobody thinks it doesn't really mean what it says because Thomas Jefferson owned slaves. King gave a brilliant and moving quotation, and I think it says we should not be treating people differently on the basis of skin color."
Many others agree. King's quote has become a staple of conservative belief that "judged by the color of their skin" includes things such as unique appeals to certain voter groups, reserving government contracts for Hispanic-owned businesses, seeking more non-white corporate executives, or admitting black students to college with lower test scores.
In the latest issue of the Weekly Standard magazine, the quote appears in the lead of a book review titled "The Price Was High: Affirmative Action and the Betrayal of a Colorblind Society."
Considering race as a factor in affirmative action keeps the wounds of slavery and Jim Crow "sore and festering. It encourages beneficiaries to rely on ethnicity rather than self-improvement to get ahead," wrote the author, George Leef.
Last week, the RightWingNews.com blog included "The idea that everyone should be judged by the content of their character, not the color of their skin" in a list of "25 People, Places and Things Liberals Love to Hate."
"Conservatives feel they have embraced that quote completely. They are the embodiment of that quote but get no credit for doing it," says the author of the article, John Hawkins. "Liberals like the idea of the quote because it's the most famous thing Martin Luther King said, but they left the principles behind the quote behind a long time ago."


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According to a news release issued earlier today by investment bank DeParis Redinger LLC, Microsoft has purchased technology from SQL Farms LLC, a Herndon, VA-based developer of management tools and utilities for Microsoft SQL Server. DeParis Redinger advised SQL Farms on the sale of the IP assets to Microsoft, and terms of the arrangement were not revealed.
In a statement from the press release, SQL Farms CEO Ron Wright said that the "strategic sale \[of SQL Farms IP to Microsoft\] validates the strength of SQL Farms' product. We understand the needs of database administrators and look forward to helping them manage their increasingly complex data farms."
SQL Farms develops configuration management and deployment automation products for SQL Server. Their first product was SQL Farms Combine, an application that allows SQL Server admins to automate and batch SQL Server management tasks.


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alz.org >> Science & Progress >> Earlier Diagnosis
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Alzheimer's and Dementia Testing for Earlier Diagnosis
What if we could diagnose Alzheimer's before symptoms started? The hope is, future treatments could then target the disease in its earliest stages, before irreversible brain damage or mental decline has occurred. Research on new strategies for earlier diagnosis is among the most active areas in Alzheimer's science, and funding from the Alzheimer's Association has spurred significant advances and steady progress.
Current diagnosis of Alzheimer's relies largely on documenting mental decline. We now know that Alzheimer's has already caused severe brain damage in individuals who are diagnosed in this way.
Researchers hope to discover an easy and accurate way to detect Alzheimer's before these devastating symptoms begin. Experts believe that biomarkers (short for "biological markers") offer one of the most promising paths. A biomarker is something that can be measured to accurately and reliably indicate the presence of disease. An example of a biomarker is fasting blood glucose (blood sugar) level, which indicates the presence of diabetes if it is 126 mg/dL or higher.
The Alzheimer's Association partnered with the National Institute on Aging (NIA) to convene expert workgroups to update the diagnostic criteria and guidelines for Alzheimer's disease.
Several potential biomarkers are being studied for their ability to indicate early stages of Alzheimer's disease. Examples being studied include beta-amyloid and tau levels in cerebrospinal fluid and brain changes detectable by imaging. Recent research suggests that these indicators may change at different stages of the disease process.
Before a biomarker can be used in medical clinics, it must be validated, in which multiple studies in large groups of people establish that it accurately and reliably indicates the presence of disease. Furthermore, the laboratory methods used to measure the biomarker must be shown to be stable and reliable. Sign up for our weekly e-news and stay up-to-date on the latest advances in Alzheimer's diagnosis, treatments, care and research.
There are currently no validated biomarkers for Alzheimer's disease, but researchers are investigating several promising candidates, including brain imaging, proteins in cerebrospinal fluid, proteins in blood and genetic risk profiling.
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Neuroimaging is among the most promising areas of research focused on early detection. Today, a standard workup for Alzheimer's disease often includes structural imaging with magnetic resonance imaging (MRI) or computed tomography (CT). These tests are currently used chiefly to rule out other conditions that may cause symptoms similar to Alzheimer's but require different treatment. Structural imaging can reveal tumors, evidence of small or large strokes, damage from severe head trauma or a buildup of fluid in the brain.
In 2012, the U.S. Food and Drug Administration approved the first molecular imaging tracer for use in patients being evaluated for possible Alzheimer's disease or other causes of cognitive decline. This tracer (brand name Amyvid but also known as florbetapir F-18), is a molecule that binds to beta-amyloid in the brain. Because it is labeled with a radioactive tracer it can be visualized during a positron emission tomography (PET) brain scan, thereby revealing the presence of amyloid plaques in the brains of living patients.
A second molecular imaging tracer (brand name Vizamyl but also known as flutametamol F18) was approved in 2013. It also binds to and reveals amyloid plaques in the brain during PET imaging. A third molecular imaging tracer (brand name Neuraceq but also known as florbetaben F18) was approved in 2014, and like its two predecessors, binds to and reveals amyloid plaques in the brain during PET imaging.
Even though amyloid plaques in the brain are a characteristic feature of Alzheimer's disease, their presence cannot be used to diagnose the disease. Many people have amyloid plaques in the brain but have no symptoms of cognitive decline or Alzheimer's disease. Because amyloid plaques cannot be used to diagnose Alzheimer's disease, amyloid imaging is not recommended for routine use in patients suspected of having Alzheimer's disease.
A Task Force of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and the Alzheimer's Association has published criteria in which they believe the use of amyloid imaging would be appropriate.
Structural imaging provides information about the shape, position or volume of brain tissue. Structural techniques include magnetic resonance imaging (MRI) and computed tomography (CT).
Functional imaging reveals how well cells in various brain regions are working by showing how actively the cells use sugar or oxygen. Functional techniques include positron emission tomography (PET) and functional MRI (fMRI).
Molecular imaging uses highly targeted radiotracers to detect cellular or chemical changes linked to specific diseases. Molecular imaging technologies include PET, fMRI and single photon emission computed tomography (SPECT).
In 2006, the Alzheimer's Association awarded a $2.1-million grant to the Alzheimer's Disease Neuroimaging Initiative (ADNI) to expand the study to include PIB-PET imaging. ADNI began as a five-year, nationwide study launched by the National Institute on Aging (NIA) to establish standards for obtaining and interpreting brain images and biological samples. Its ultimate goal is to determine whether standardized imaging protocols, possibly combined with laboratory and psychological tests, may offer a better way to identify high-risk individuals, provide earlier diagnosis, track disease progression and monitor treatment effects, especially in clinical trials of disease-modifying drugs. Learn more about our commitment to research.
CSF is a clear fluid that bathes and cushions the brain and spinal cord. Adults have about 1 pint of CSF, which physicians can sample through a minimally invasive procedure called a lumbar puncture, or spinal tap. Research suggests that Alzheimer's disease in early stages may cause changes in CSF levels of tau and beta-amyloid, two proteins that form abnormal brain deposits strongly linked to the disease.
One challenge researchers face is that analysis of protein levels in the same sample often varies significantly from institution to institution. Achieving consistent measurement is a barrier that has been overcome in other medical conditions by using a standard procedure protocol and comparing results from the same sample at multiple sites designated as reference laboratories. To facilitate consistency in analyzing Alzheimer-related CSF proteins, the Alzheimer's Association has funded the Alzheimer's Association QC Program for CSF Biomarkers. Organizations can compare their sample analysis outcomes to results at reference laboratories in the United States and Europe.
To facilitate cross-institutional consistency in analyzing Alzheimer-related spinal fluid proteins, the Alzheimer's Association has funded the Alzheimer's Association QC Program for CSF Biomarkers. Organizations can compare their sample analysis outcomes to results at reference laboratories in the United States and Europe. Learn more about our commitment to research.
Researchers are also investigating whether presymptomatic Alzheimer's disease causes consistent, measurable changes in urine or blood levels of tau, beta-amyloid or other biomarkers. In addition, scientists are exploring whether early Alzheimer's leads to detectable changes elsewhere in the body. For example, Lee Goldstein, MD, PhD, has been funded by the Alzheimer's Association to investigate whether beta-amyloid forms characteristic deposits in the lens of the eye.
Scientists have identified three genes with rare variations that cause Alzheimer's and several genes that increase risk but don't guarantee that a person will develop the disease. Investigators worldwide are working to find additional risk genes. As more effective treatments are developed, genetic profiling may become a valuable risk assessment tool for wider use.
Genetic testing for APOE-e4, the strongest risk gene, is included in some clinical trials to identify participants at high risk for the disease. APOE-e4 testing is not currently recommended outside research settings because there are no treatments yet available that can change the course of Alzheimer's.
In 2003, the Alzheimer's Association partnered with the National Institute on Aging (NIA) to publicize and recruit participants for the National Alzheimer's Disease Genetics Study, a landmark initiative launched in 2003 to clarify genes involved in late-onset Alzheimer's by creating a privacy-protected database of blood samples and family information. The National Alzheimer's Disease Genetics Study is still recruiting families with Alzheimer's disease. Learn more about participating.
Research has shown that individuals with mild cognitive impairment (MCI) have a significantly increased risk of developing Alzheimer's disease within a few years, compared to people with normal cognitive function; research surrounding MCI offers another potential path to earlier diagnosis.
Individuals with MCI have a problem with memory or another mental function serious enough to be noticeable to themselves and those close to them and to show up on mental status testing. These problems, however, are not severe enough to interfere with daily activities, so the person does not meet current diagnostic criteria for Alzheimer's or another form of dementia.
Although individuals with MCI may go on to develop Alzheimer's disease, this is not always the case. In some people, MCI never gets worse. In others, it eventually gets better.
Investigators are trying to answer the following questions to increase MCI's usefulness as a diagnostic category:
Individuals with MCI are among the participants currently enrolled in ADNI, and their participation will help bring researchers closer to answers for these questions.
The Alzheimer's Disease Neuroimaging Initiative, already mentioned in the section on Brain imaging, was extended in both 2009 and 2010 by the ADNI-GO and ADNI-2 initiatives. ADNI-GO is complete, but ADNI-2 is ongoing and recruiting participants. As with the original ADNI study, ADNI-2 seeks to understand how MCI and Alzheimer's disease progress. A primary goal is to determine how symptoms and biomarkers of MCI and Alzheimer's disease change during disease progression, and how the various symptoms and biomarkers are related. Another goal is to develop standards for brain imaging and biomarker tests.
The Alzheimer's Association is also a major sponsor of World Wide ADNI (WW-ADNI), an effort to unite scientists from the North American ADNI projects with those involved in other ADNI projects around the world including Europe, Japan, Australia, Taiwan, Korea, China, and Argentina. It is anticipated that this collaborative effort will accelerate the pace of progress and strengthen the scientific findings by including more diverse participants.
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TASHA: I'm waiting for my best friend, Raquel Mitola, to finish seeing the ob. She'd taken a home pregnancy test and called me with the news, and as she walks back into the waiting room -- beaming -- I know the doctor has confirmed what we were both praying for. Her pregnancy is looking good.
I'm next. The doctor tells me everything is fine, too, but I focus on being happy for Raquel. See, I've been pregnant 11 times before -- and each pregnancy has ended in miscarriage. And Raquel, a mom of two, offered to be my surrogate. So thanks to my friend, I'm going to be a mom.
JOHN: That day we found out that both Tasha and Raquel were expecting, we wouldn't let ourselves get too excited about Tasha's pregnancy because of everything we'd been through. Tasha and I got married in 1999, when she was 28 and I was 29, and we started trying to have children right away. She got pregnant immediately, but after about a month and a half, she miscarried. So we tried again. And again, Tasha would get pregnant but then have another miscarriage. It was devastating.
TASHA: When you have a miscarriage, you hear how common it is. Everyone says, "Oh, don't worry, it happens to so many women. You'll be fine." And I tried to stay positive. But after my fifth miscarriage, we decided to see a fertility specialist, who diagnosed me with "recurrent pregnancy loss" -- the loss of three or more pregnancies in a row. It affects only 1 percent of couples, and the worst part is that most of the time it goes unexplained. You'd think a diagnosis would have given us more clues as to why my body wasn't keeping the pregnancies, but it didn't.
During all of this, John's support was incredible. He'd talk me through the miscarriages, and a lot of times he had a more positive outlook than I did. He believed we would have a baby one day and always reminded me of that when I'd start to lose hope.
JOHN: I wanted to be strong for Tasha, despite how upset I was for both of us. I've watched her with our nieces and nephews, and I always knew she'd be a great mom. And it was hard for me to think that she might never get a chance to experience that.
But one thing I always told her was that whenever she was ready to stop trying, I would understand. I didn't want her to feel like she was letting me down. We would have to accept whatever was going to happen and try to move on.
TASHA: After my seventh miscarriage, in January 2003, Raquel called and offered to be a surrogate for me. Raquel's been my best friend since fifth grade, and even though she lives about two hours away, we've always tried to spend time together at least once a month. She told me she loved being pregnant with her two kids -- Mickelle, who's 16, and Chase, who's 13 -- and she'd talked it over with her husband, Jeff. I was so touched -- it was such a kind offer from our close friends, but John and I wanted to exhaust all of our options first.
Two years and three more miscarriages went by -- and then we got a call from a woman in our town who'd known about our struggle to have a baby. Her 17-year-old daughter was almost seven months pregnant and she wanted John and me to adopt the baby. We bought a few little outfits -- she'd told us it was going to be a boy -- and that got us so excited. But just a month before the baby was born, we got another call from the woman: Her daughter had decided to keep the baby. John and I were left crying in each other's arms -- again.
A light at the end of the tunnel
JOHN: After the adoption didn't work out, the fertility specialist, Dr. Douglas Austin, suggested in vitro fertilization. Although Tasha never had trouble getting pregnant at first, it was taking us longer to conceive, and he told us about some studies that showed IVF has high success rates in women who have recurrent pregnancy loss. So even though it was a financial struggle, we came up with the more than $10,000 it would cost and hoped that finally Tasha would carry a baby to term. He fertilized 30 of her eggs with my sperm and implanted Tasha with three embryos.
She made it to about ten weeks.
The next time we saw Dr. Austin, he told us we should try a surrogate.
RAQUEL: In the summer of 2005, Tasha and John came over and told us about that last miscarriage. We all cried. Then John told us what Dr. Austin had said about having a surrogate, and we didn't even have to think about it -- we said we'd do it.
Dr. Austin started me on hormone therapy and implanted me with two of Tasha and John's embryos that had been frozen from their first IVF attempt.
JOHN: Dr. Austin also talked to us about implanting Tasha one last time. Tasha wasn't very enthusiastic about that -- she was convinced she already knew what the outcome would be. But he felt that if Raquel got pregnant and Tasha hadn't tried, it would have been harder to watch Raquel have the baby. We agreed, and the doctor implanted Tasha with five frozen embryos.
One thing Dr. Austin kept telling us was how great our surrogates were: Jeff was extremely supportive -- he didn't mind that his wife was carrying Tasha's baby -- and neither Jeff nor Raquel had any ulterior motives. When Dr. Austin asked them why they were doing this, they told him, "It's simple. These people are our friends, and they need our help."
TASHA: About two weeks after Raquel and I were implanted, she called me and asked, "If I took a pregnancy test, would you want to know the results?" I said yes. And that's when she yelled, "I'm pregnant!" I started crying. I called John as soon as I got off the phone with Raquel -- we were thrilled.
I took a blood test and discovered I was pregnant, too. A few weeks later, Raquel and I met at Dr. Austin's office for our first sonograms. He told us some news neither of us was expecting: We were both carrying twins!
I was ecstatic about Raquel. We had a good feeling that she'd be able to carry the babies to term. But I wouldn't let myself get too excited about the babies I was carrying.
Then I hit the two-month mark, then four months. When I was six months along, I started having weekly doctor appointments, and things were going really well. That's when John and I were both like, "Oh my gosh, we're going to have four babies!"
Dr. Austin said it's impossible to say why I was able to keep these babies -- maybe because I was under much less stress this time around. Once I found out Raquel was pregnant, I put all my energy and heart into making sure she would carry the babies to term -- and I knew that whatever happened with my pregnancy, I'd still become a mom.
RAQUEL: Everyone in my family was very excited about my pregnancy -- I never got a negative reaction about it, not from friends, or Jeff, or the kids. Plus, Tasha and I had so much fun being pregnant together. We had all of our appointments with Dr. Austin at the same time, so we really went through everything together.
We also compared notes on morning sickness, aching feet, and food cravings. One day I called Tasha from the market. I was buying strawberries because I'd been craving them. When I told her that, she laughed -- she was sitting on the couch eating strawberries and watching Oprah. Stuff like that happened a lot! We knew exactly what the other was going through -- and we turned to each other for advice and support all the time.
Becoming a mom
TASHA: On May 10, 2006, I got a call from Raquel; she was on her way to the hospital. Even though both babies were breech, her labor progressed quickly, so we didn't make it in time to watch her c-section. But when we saw our daughter, Ayla, and our son, Jalen, for the first time, John and I found ourselves crying in each other's arms again. But this time, it was for a very different reason.
I've been asked to describe that moment when I first saw my children, but I can't. It was awesome, emotional, incredible -- all those words combined. We were just amazed at how you can love two little people so much so fast. I think every parent feels that overwhelming joy.
We brought the babies home and got them settled. Then just over a week later, on May 18, John drove me to the hospital. I already knew I was going to have a c-section -- one of my babies was breech, too.
On the drive there, I realized that, finally, I wasn't guarded anymore. I knew I'd meet my younger set of twins soon, and I couldn't wait.
JOHN: Lennon came out first, and I was in awe. Seeing her take her first breath -- it was really incredible. Then Mirra was born, and our family was finally complete.
It's been almost a year since their births now, and we're still figuring out how to juggle babies! During the first seven weeks, Tasha's mom and my mom would come for a week at a time, as would Raquel and her kids. When the babies were 3 months old, we hired a nanny.
Still, getting them to sleep or eat or stop fussing -- things like that have been such a huge learning experience, figuring out what works and what doesn't. But four babies or one, we're just like all other new parents -- learning a lot every day.
TASHA: I don't think having these babies is sweeter because of what we've been through; all parents love their babies so incredibly despite how long it took them to get pregnant. We do feel lucky. Even now, I go into the nursery and see them in their cribs and I get so emotional -- I'm just so happy with what we have.
Our struggles having these babies have definitely made us stronger, but I know that each situation in life will bring different challenges and emotions. It's not like I feel that I can get through anything now because of what we've been through, but this has certainly made me more hopeful.


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By Mitch Kramer
We've just completed our evaluation of Salesforce Service Cloud Winter '15, which provides case management and contact center support, and its collection of tightly integrated but variously packaged and priced features and add-on products for knowledge management, chat, social customer service, and communities. The full 60-page report is available to our Customers.com Technologies Service members. But here's an important highlight of interest to all of you:
Salesforce Communities
Salesforce Communities is one of the new capabilities in Winter '15. It packages an attractive set of facilities that let customers perform a wide range of collaboration and self-service activities and tasks. However, none of these facilities use new technology; all of them have been existing features of Salesforce applications. What's new and what's innovative is their use as the platform for customer self-service. With Communities, Salesforce.com has extended the customer service provider-centric, web content-intensive self-service of portals with social and collaborative self-service that lets customers (and customer service agents) answer and solve customers' questions and problems. Here's what we mean.
Continue reading "Salesforce Service Cloud Winter '15 Improves Self-Service with Salesforce Communities" »


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chastity | MOST RECENT | POPULAR | BUZZ |
Opinion: Life
Get Married! The Case for Tying the Knot Early
Posted byon 02.18.08 |
I enjoyed reading Lori Gottlieb's funny and insightful "Marry Him! The case for settling for Mr. Good Enough, in the March issue of The Atlantic. At 40 years of age, Ms. Gottlieb finds herself an attractive, intelligent, successful woman whose marriage prospects are plummeting like a skydiver without a parachute. She made the seemingly… READ MORE >
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This week's cooking with Dad recipe comes from Rachel Ray. Ray's recipes are always easy and time efficient – think 30 minute meals. This one is no different. I'm a vegan, so I substitute all the animal proteins for healthy veggie alternatives. Enjoy.
2 tablespoons extra-virgin olive oil, 2 turns of the pan, plus some for drizzling
16 crimini mushroom caps, baby bella's, with stems, trimmed and thinly sliced
12 shiitake mushrooms, thinly sliced, stems discarded
Coarse black pepper and salt
1 tablespoon (a few sprigs) fresh thyme leaves, chopped, or 1 teaspoon dried
4 large flour tortillas, 12 inches in diameter
2 cups shredded sharp white cheddar (I use Vegan Block Cheddar Flavor or Rice Vegan Block Pepper Jack Flavor from Galaxy Nutritional Foods).
1 tablespoon extra-virgin olive oil, 1 turn of the pan
1 small onion, chopped
2 cloves garlic, chopped
1 jalapeno pepper, seeded and chopped
1 can black beans, drained
1 cup frozen corn kernels
1/2 cup sun-dried tomatoes in oil, chopped
1/2 cup smoky barbecue sauce
Salt and freshly ground black pepper
Heat a medium nonstick skillet over medium heat. Add the oil and the sliced mushrooms to the hot skillet. Season mushrooms with black pepper, salt and thyme. Sauté the mushrooms 10 minutes or, until dark and tender, then remove from heat. Transfer the mushrooms to a dish and return the skillet to the stove over medium heat.
Add another turn of extra-virgin olive oil to the skillet and add the onions, garlic and jalapeno pepper; sauté for 2 or 3 minutes, then add beans and corn to the pan. Stir in chopped tomatoes and barbecue sauce, then season salsa with salt and pepper. Transfer warm salsa to a serving dish.
Heat a griddle pan or large nonstick skillet over medium to medium high heat. Add a drizzle of oil to the pan and 1 flour tortilla. Cook tortilla 1 minute, and then turn it over; sprinkle 1/2 cup sharp cheddar over 1/2 of the flour tortilla. Cover the cheese with 1/4 of the cooked sliced mushrooms. Fold the plain 1/2 of the tortilla over top of the filling and gently press down with a spatula. Cook the filled quesadilla 30 seconds to a minute longer on each side to lightly brown and crisp the quesadilla and melt the cheese. Remove the quesadilla to a large cutting board or transfer to a warm oven to hold, and then repeat with remaining quesadilla ingredients.
Cut each quesadilla into wedges and serve with warm salsa for topping.
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