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A rat infestation at an abandoned property has affected surrounding residents. And city officials are worried about public health.
HAINES CITY | A rat infestation at an abandoned property has affected surrounding residents. And city officials are worried about public health.
"Rodents harbor disease," City Manager Jonathan Evans said, "and when you're having that type of infestation impacting adjacent property owners it's a cause for concern."
Residents near the corner of Dr. Martin Luther King Jr. Way and Avenue D are looking for some relief, and city officials hope it will come sooner rather than later.
Rats, possums and snakes have made a home inside an abandoned property, 1214 Dr. Martin Luther King Jr. Way, and the surrounding residents have been dealing with the consequences for several years.
"It needs to be cleaned up and cleaned out," said Janet Smith, the owner of four adjacent apartments. "I need some peace."
Vacant since the trio of hurricanes that blew through Polk in 2004, Smith said, the abandoned property was once a retail shop with an apartment attached.
According to the Polk County Property Appraiser, Gary Wright has owned the property with his mother, Diane, since 2005.
Trash and debris litters the side and back yards, and the condition of the roof has made the structure unsafe to occupy. With no one maintaining the building, it continued to deteriorate and draw rodents over time. Evans said the owners are from the Orlando area.
The first lien was levied against the property in 2006, said Richard Greenwood, the city's community development director, and Wright hasn't made any effort to bring the property in compliance with city code for the past several years.
Wright declined to comment for this story.
Wright's wife, Trina, said there have been some disputes between neighbors in the past.
"This has been handled irresponsibly," she said. "There was never an issue until a couple years ago."
She declined to comment any further.
Meanwhile, nearly 10 residents living on that block have been dealing with the infestation.
Smith, 84, is retired and has tenants renting the four apartments she owns behind the Wright property.
She said she has spent more than $100 on poison trying to contain the rat infestation by herself.
Despite her efforts, a rat has crept into her tenants' apartments on a couple of different occasions.
Two of her tenants declined comment and the others were unavailable.
As of Monday, the property has more than $320,000 in code enforcement liens, and until recently, Wright has shown no interest in working with the city.
"The intent behind code enforcement is compliance-based," Evans said. "The fine is the proverbial stick to draw compliance — but what happens if they don't fear the stick?"
After threat of foreclosure, however, Wright expressed no desire to keep the property, which has an assessed value of $32,170, according to the Polk County Property Appraiser.
City officials will step in by conducting a title search, which will identify any other stakeholders on the Wright property — including state and federal liens.
Pending further information from a title search, if Wright is willing to hand over his property, the city will have a couple of options: repair it or tear it down.
In 1955, the 3,352-square-foot multi-use structure was built on the corner of Dr. Martin Luther King Jr. Way and Avenue D.
The concrete building has a retail store with an attached two-bedroom, one-bathroom apartment.
In 1971, Fred and Martha Willingham sold the building to Arthur and Diane Wright, Greg Wright's parents, for $12,900, according to the Property Appraiser's Office.
Over the years, the retail shop changed identities multiple times, Smith said, and the apartment tenants have come and gone.
However, the Wright property was damaged in the three hurricanes that tore through Polk County in August and September 2004, Smith said, and that's when the problems began.
To the city's knowledge, no effort has been made by the property owner to repair the damage.
The tenants moved out and no one has occupied the retail store since. The property's condition went downhill as a result, and then came the fines.
Haines City Code Enforcement started levying fines in 2006 based on a damaged canopy that hung over the sidewalk adjacent to Dr. Martin Luther King Jr. Way.
Throughout the years, fines continued to accrue and trash continued to accumulate, said Steve Shifley, the city's code enforcement supervisor.
This continued until February, when Special Master Heather Christman authorized city officials to tear down the canopy.
It was gone a month later.
Shortly after that hearing, Evans said, the structure was deemed unsafe for occupancy because of the damaged roof. And Wright still was not cooperating with the city.
"It's really a problem of property owner versus property owner," Evans said, "but at some point the city has to step in."
Technically, the city can only step in if there is a threat to public health, safety and welfare, but this situation is officially only creating a nuisance, Evans said.
However, after several years of noncompliance from Wright, as well as the accumulation of trash and the gathering of rodents, the city had no other choice.
In order to circumvent the property owner's lack of cooperation, city officials began looking at whether the structure could be demolished based on a threat to public health, safety and welfare.
However, in order to have a demolition order passed by Special Master Christman at a code enforcement hearing, a couple of factors are looked at.
First, is the structure repairable?
Greenwood said it is.
Second, does the structure pose a safety hazard?
Greenwood said other than the roof, the building is structurally sound and there is no hazard at this time.
The problems associated with the building are the rats and the odor, Greenwood said, which is not considered a "serious threat."
"We're kind of in between a rock and a hard spot," Greenwood said.
On April 23, another code enforcement hearing was held, and city officials prepared an order to begin foreclosure based on more than $320,000 in liens against the property.
After threat of foreclosure, however, Wright reached out to city officials and expressed no desire to continue his ownership of the property.
Now it's just a matter of the city obtaining the abandoned property and addressing the nuisance.
"This property has been an eyesore in our community for a long period of time," Evans said at the April 23 code enforcement hearing. "So we would definitely like to mitigate this issue sooner rather than later."
Nothing has been completed yet, but if Wright decides to sign the deed to his property over to the city, officials will have a couple of different options.
First, to let the building remain, the property has to comply with city code.
To clean the debris off the property and make all the necessary repairs would cost nearly $50,000.
With an assessed value of $32,170, city officials are more inclined to wipe the slate clean and demolish the property, which would cost nearly $10,000.
However, the city manager's spending limits are $5,000, so Evans would have to go to commissioners for approval first.
Demolition would be the most beneficial option for the city, Evans said, because of the cost.
The city also would have to spend $2,000 for an outside company to exterminate the rat problem.
With an empty lot free from rodents, Evans would go to the commission with a few different options:
Team up with Habitat for Humanity to build a house for a family in need.
Sell the lot for the appraised value.
Expand parking lots for city facilities a couple blocks away.
Currently, city officials are conducting a title search to see if there are any other stakeholders in the property.
If the title search doesn't hit any snags and with the deed to the property in hand, the demolition could take place in 30 to 45 days, Evans said.
"My principal concern is the health, safety and welfare of the residents in the surrounding area," Evans said. "I would hate for us to continue this process for another year, while (Smith and her tenants) have to deal with rodents."
Regardless of what the city decides to do with the property, the residents may get tired of the problem and move out before the rats do.
"The rats are still running around," Smith said. "I can't make (the city) speed up, but I wish they could do something sooner — this is costing me money."
Cody Dulaney can be reached at firstname.lastname@example.com or 863-401-6969. Follow him on Twitter @dulaneycd.


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Linda Stricklin
Assistant Coach - Women's Basketball
- 1140 Umpqua College Rd
Roseburg, OR 97470
Physical Education Complex
- 541-440-7737
Linda begins her thirteenth season as a UCC assistant and her primary responsibilities include conducting individual workouts, assisting with on the floor coaching, recruiting, and overseeing the team's strength and conditioning workouts.
A graduate of Sutherlin High School in Sutherlin, OR Linda was named All Sky-Em League and All State in basketball, volleyball, and track and was named the SHS Female Athlete of the Year. Following high school Linda decided to concentrate solely on basketball and helped lead Umpqua to a 29-4 record and it's first ever NWAACC Championship. For her efforts she was named to the NWAACC All Southern Region and All Freshman Teams despite having played half the season with a broken hip. As a sophomore, Linda was named All Southern Region, All District 8, and Honorable Mention Kodak All American and played in the NWAACC All Star game. That spring she accepted a scholarship and signed a national letter of intent to play basketball at Metro State University in Denver, Colorado.
Linda's favorite food is chicken and Dr. Pepper and she likes watching both college and pro football on TV. She also likes country music and following the work of her favorite artist - 14 year old daughter Taylor. Linda received her master's degree from Western Oregon University.

subset: commoncrawl


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I write this report a few hours before the Moon is full is at 3:26 pm (EST). The Moon is the handle on the 'bucket' pattern of this chart. She works hard, quite alone, as a full Virgo Moon might prefer! Yet she is in relationship (aspect) to many other planets at this powerful moment of manifestation. She is, as a full Moon must always be, exactly opposite the Sun situated between those long term travelers, Chiron, the healer and Neptune, the planet of dreams, music and art, mysticism and illusion. The Moon in her sensible Virgo attire must balance out this Piscean crowd of misty travelers. Mars, and Mercury, who just went retrograde are also in Pisces. It's hard to imagine much happening on the material plane, yet this is a great time to travel the misty aspects of your life to discover new possibilities!
Pluto in Capricorn (trine the Moon) and the Virgo full Moon are the only planets in signs of the Earth element. It is the practical Earth element who creates the final stage of manifestation. However, since the Moon and Pluto are powerful actors in this drama of the moment, something on the visible realm may appear against a very hard to define background.
Jupiter squares the Sun and Moon as well as Chiron and Neptune. Jupiter is the ruler of Pisces, and seems to have an important message (Gemini) for this particular moment. Let's look at the Sabian symbol for Jupiter to see if we can discern his message:
'KEYNOTE: The wholesome enjoyment of organic processes and emotional drives.'
This seems to suggest we turn to natural rhythms and take pleasure in what takes place around us as the season begins to change. If we lighten our demands upon ourselves and the universe in general we can heal wounds kept open by fear and resentment.
Mercury's retrograde journey in Pisces will end on March 17, St. Patrick's day, in preparation for the spring equinox. His other two retrograde periods will take place in Cancer and Scorpio this year so we will have many opportunities to enjoy the full expression of the water element. We can float in a sea of emotional expression, write romantic poetry and generally enjoy wetness.
The Moon's heavy lifting may be assisted by Saturn in Scorpio who trines her and lets her know she is quite adequate to job. If you feel inadequate to some task, you might also call on Saturn for assistance from his deep cave in the Scorpionic netherworld.
Pluto's trine to this hard working Moon allows her to lean on his Capricorn knowledge of world's structure. According to her Sabian Symbol for this degree of the full Moon,
KEYNOTE,' Learning to use one's capacity for emotional self-expression according to cultural standards, this is a time of initiation into new territory. What new step are we each willing to venture during this period of full Moon excitement?
The Sun's Sabian Symbol: 'A GIRL BLOWING A BUGLE.
KEYNOTE: A call to participation in the service of the race, as an evolutionary crisis approaches.' Both seem to suggest new potential for growth whether or not we feel ready. Perhaps that is the way the plants feel lying under a heavy load of snow here in New England even as they prepare for the push which comes as the Sun enters Aries and spring arrives in the Northern Hemisphere! Enjoy the rising of this brave and initiatory Virgo full Moon tonight at 5:41 pm. Forget the perfection compulsion that Virgo may bring along and try something new and revelatory.
Keeping our Ancient Wisdom Alive
The Wisdom Tradition evolved over the centuries to address our deepest human needs.
Sarah Fuhro is a practitioner of its many forms; including Astrology, Tarot, Flower
Essences and Druidry. In addition to personal consultations, Sarah teaches workshops
and private classes, offering both clients and students knowledge powerfully rooted
in the past, presented in the language of the present. To learn more, please visit


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It's an Army thing
With music setting the tone and an ample dose of exuberance to get outdoors and enjoy some beautiful weather, Toll Gate students stepped forward to compete in a number of team and individual competitions that were all part of a visit to the school from the U.S. Army on Thursday. "They were the friendliest to the military or could benefit most from the visit," said recruiter Sgt. Josh Leonard when asked how the school was picked for the visit. It may have helped that he is a Toll Gate grad. The Army team and their trucks of equipment – the "Army Strong Challenge" – also visited Pilgrim, the only other Rhode Island school where they made a stop. Toll Gate's Sue Clegg, director of physical education and health, also had a hand in lining up the visit. She was anxious to get the kids involved in a physical activity and outside. Leonard said activities offered during the visit aim to encourage fitness and teamwork while introducing students to the Army. On average, he said, one out of 100 students has an interest in going into the military. But it takes more than that. He said that less than half of 1 percent qualify to serve. (Warwick Beacon photos)


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Will he or won't he?
That's the question that's been buzzing around singer Josh Groban regarding a possible starring role on Broadway.
The Internet has been revved up this month on the speculation that began earlier this year with the release of "Stages," Groban's album of Broadway show tunes.
Then he appeared on the Tony Awards in June leading a chorus of 175 Broadway cast members in a rendition of Rodgers & Hammerstein'sinspirational song "You'll Never Walk Alone" from "Carousel."
When I talked to him around that time, Groban was careful not to send too strong a signal about his interest in a starring role on...


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Hungarian foreign minister slams far-right lawmaker's call to register Jews as security risks
VIENNA (AP) — Hungary's foreign minister said Wednesday that calls by an extreme-right politician to register the country's Jews as potential security risks were "completely unacceptable" and the worst yet in a series attributed to the legislator's party.
Janos Martonyi also denied suggestions that his country was lenient with neo-Nazis and other right-wing extremists, telling reporters "Hungary does not put up with" actions by such groups and individuals.
Martonyi's comments reflect Hungary's attempts to deal with the fallout from the remarks by Marton Gyongyosi of the far-right Jobbik party, which generated headlines across Europe and outraged human rights activists.
Gyongyosi told the legislature last week that it was time "to assess ... how many people of Jewish origin there are here, and especially in the Hungarian parliament and the Hungarian government, who represent a certain national security risk."
Gyongyosi later apologized to "our Jewish compatriots" for his statement, but added that Hungary, a nation of about 10 million people, needs to be wary of "Zionist Israel and those serving it also from here."
Some 550,000 Hungarian Jews were killed in the Holocaust. Hungary's Jewish population is now estimated at 100,000.
Virgin Mary loses her head in Senegal and president says probe has been launched
DAKAR, Senegal (AP) — The Virgin Mary has lost her head and the president of Senegal says investigators are on the case.
The head is missing from a statue of the Virgin Mary at a church in a suburb of the capital, Dakar. Cardinal Theodore Adrien Sarr condemned the desecration Wednesday and called on Catholics to exercise restraint. He said someone removed the head late Saturday in the church courtyard.
President Macky Sall says security forces have launched an investigation.
Nearly 160 graves were damaged in the two largest Christian cemeteries in Dakar nearly two months ago, with crucifixes, statuettes and other pieces made of bronze removed.
Senegal is a predominantly Muslim country in west Africa where Muslims and Christians coexist peacefully.
Patriarch of Syria-based Eastern Orthodox church, Ignatius Hazim, dies in Beirut at 91
BEIRUT (AP) — Syria's official news agency says the patriarch of a Damascus-based Eastern Orthodox Church, Ignatius Hazim, has died in a Beirut hospital. He was 91.
Hazim was named Eastern Orthodox Patriarch of Antioch and all the East for the Greek Orthodox in 1979. His church is known as the Greek Orthodox Church of the Antioch.
The SANA news agency says the cause of Hazim's death was a stroke. He died in Beirut's St. George's hospital on Wednesday.
Hazim hailed from the Syrian town of Mhardeh near Hama.
The agency says his remains will be brought from Lebanon to Syria for burial.
There are a number of Eastern Orthodox churches in the Middle East, including Greek Orthodox and Maronite church.
Baby Jesus figure stolen last year from Pa. Nativity scene is returned; replacement taken
CHAMBERSBURG, Pa. (AP) — A baby Jesus figure taken from a Pennsylvania church's Nativity scene last year was found cradled in the arms of a nearby statue, just hours before the replacement statue was swiped.
The vintage figurine was taken last year from outside Chambersburg's Central Presbyterian Church. It was found Sunday in the arms of a bronze Civil War soldier statue across the town square.
A local business had replaced the Jesus statue when the Nativity scene was set up a couple weeks ago. The Chambersburg Public Opinion reports that replacement statue was swiped sometime after services on Sunday.
Congregant Buffy Super calls the statue's return a "Christmas miracle." Another says the church will have to considering securing the statue to deter theft.
Queen and country over God? Britain's scouts propose new oath to let atheists in
LONDON (AP) — Atheists could be allowed into Britain's boy and girl scouts after more than a century.
Although there have been alternative oaths for Muslims, Hindus and Buddhists for decades, there have been no such exceptions made for atheists. Wayne Bulpitt, the association's chief commissioner in the UK, said the proposed change is meant to keep the group relevant and to encourage membership.
But he said Tuesday the group plans to keep its oath to the queen.
The scouting movement began more than a century ago and now encompasses some 40 million members worldwide.
In October, a San Francisco Bay-area teenager was kicked out of the Boy Scouts because of the organization's national policy of excluding gay members.
Tennessee governor rebukes critics of Muslim aide, says she has been 'unfairly maligned'
NASHVILLE, Tenn. (AP) — Tennessee Gov. Bill Haslam has issued his strongest defense yet of a Muslim aide who has been criticized for once working in the field of Shariah-compliant finance.
The governor was asked after a speech to a Nashville Republican group on Wednesday whether he was incorporating elements of Islamic law into state government. Those allegations began to emerge after the Haslam administration earlier this year hired Samar Ali to work in the Department of Economic and Community Development.
Haslam said Tuesday that Ali has done nothing to deserve the criticism, and that she has been "incredibly unfairly maligned."
Haslam deputy Claude Ramsey in August wrote a letter to GOP leaders in an effort to dispel confusion over Ali's role and to underline the state's rejection of the promotion of any religion.


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Melvin S. Shriver, 'the Colonel,' former steelworker
Jan. 28, 1931 – April 25, 2013
Melvin S. Shriver, a longtime switchman and conductor at Republic Steel, died Thursday at his home in Depew after a long illness. He was 82.
Mr. Shriver began working at Republic Steel in 1948 and took a second full-time job at Mercy Hospital of Buffalo in 1969. To further provide for his seven children, he worked part-time as a Buffalo Taxi cab driver on weekends. After the plant closed in 1984, he worked as a housekeeper with Global Concepts for almost 10 years.
Mr. Shriver lived much of his life in South Buffalo, where he was nicknamed "the Colonel" by neighborhood children. He was known for his meticulously groomed handlebar mustache, his beautifully cultivated rose bushes and his love of old automobiles.
Mr. Shriver was a member of St. Matthews Episcopal Church and St. Simon Episcopal Church. He was also a longtime member of the National Rifle Association, the AARP and the Handyman's Club.
His wife of 56 years, the former Lowella Weaver, died in 2007.
He is survived by five sons, Melvin, Ronald, Dennis, William and Christopher; two daughters, Darlene and Mary Mazurek; and two sisters, Henrietta Weaver and Irma Pisano.
Services will be held at 10 a.m. Tuesday in St. Simon's Episcopal Church, 200 Cazenovia St., Buffalo.


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< Home Prices
Mar 05, 2013 07:23
Category: General News
Category: General News
Marijuana Law Violates International Treaties
DENVER (AP) — A United Nations drug agency says the legalization of marijuana for recreational use in Colorado and Washington violates international drug treaties. The International Narcotics Control Board is urging the Barack Obama administration to challenge the legalization measures. It made its appeal in an annual drug report released today. Marijuana is illegal under federal law


text: justice66 3 #1 Posted December 13, 2012 I was at my local homedepot ( on military highway for the locals guys) and they have 23/32 cabinet grade plywood for $29 a sheet. I was wondering if it can be used to build a sub box. It is either that or traditional mdf. It just looks like a good deal I can't find the 13 ply Baltic birch everyone talks about so I was hoping I could use it. My box will be 2 layer thick if that matters. Thanks for the help.-Jon Share this post Link to post Share on other sites


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February 9, 2009
Listen to Audio (22 min.)
Please note: These files can be quite large. Allow some time for them to download.
There's nothing like hearing the results of studies directly from those who actually conducted the research. In this interview, you'll meet two of these impressive HIV researchers and read their explanation of studies they presented at CROI 2009. After their explanation, they will answer several questions from the audience. This discussion was moderated by John Mellors, M.D.
John Mellors: Since the discovery of potent HIV protease inhibitors [PIs], a common theme of that class has been rapid metabolism and clearance from the bloodstream, requiring twice-daily or three-times-daily dosing. The use of ritonavir [RTV, Norvir] as a metabolic inhibitor of protease inhibitors caused a major advance in protease inhibitor-based therapy by allowing greater exposure with less-frequent dosing. That strategy has been dependent on one molecule, ritonavir, that is the intellectual property of Abbott Laboratories. It is only co-formulated with Abbott's protease inhibitor, lopinavir [LPV], and has been a bottleneck in efforts to co-formulate medications.
There has been a hewing cry and various protests about the availability of only one boosting agent. Also, there's been concern at a regulatory level and among clinicians about the effects of a boosting agent, such as ritonavir, used without a protease inhibitor -- let's say, used with an integrase inhibitor like elvitegravir [EVG].
Brian Kearney, Pharm.D.
This morning we presented data on GS-9350,1 our pharmaco-enhancer. It shares with ritonavir a mechanism-based inhibition of cytochrome P450, which is critical in terms of being able to administer a low dose, as infrequently as once a day -- to provide not only boosting of bioavailability, but slowing of systemic clearance, to allow for optimal pharmacokinetics of the drugs that we choose to boost.
As John mentioned, the anti-protease activity that molecule has raises certain questions about its ability to select resistance even at a low boosting dose. In our development program we specifically sought to have the mechanism-based inhibition that ritonavir has and remove the anti-HIV activity -- and we were able to successfully do that.
Then there were other factors that we considered in ultimately choosing GS-9350. These included, broadly speaking, improvements in other areas of its DMPK profile -- drug metabolism and pharmacokinetics. That includes more specific inhibition of cytochrome P450 3A [CYP3A] relative to competitive inhibition of other enzymes; the 2C family and 2D6 are also inhibited by ritonavir.
Also, ritonavir has a certain amount of liability in terms of being able to reduce metabolism: Whereas it boosts effectively in the background, it can cause induction. We've removed the induction liability as well by removing [GS-9350's] activity in terms of activation of nuclear receptors. And that induces a number of drug metabolizing enzymes as well as drug transporters.
Slide from GS-9350 presentation; Brian Kearney et al. CROI 2009; abstract 40. Reprinted with permission. Click here to view the full presentation.
The last, and one of the key, aspects of selection of GS-9350 was its high aqueous solubility. What that allows us to do is formulate it in a solid dosage form; it also allows for a co-formulation potential.
When all of those attributes were met, we moved into the clinic and conducted two clinical studies. The first clinical study was for safety and tolerability. It was a single- and multiple-dose study, and we looked to also establish proof of concept in terms of its ability to boost CYP3A substrates. In our study, we chose to use the validated probe midazolam. We showed that GS-9350 was able to reduce metabolism of midazolam, this 3A substrate, to the same extent that ritonavir is able to do at its boosting doses.
Slide from GS-9305 presentation; Brian Kearney et al. CROI 2009; abstract 40. Reprinted with permission. Click here to view the full presentation.
Based on those data, we'll move forward into Phase 2 with this quad tablet in a head-to-head study versus Atripla [efavirenz/tenofovir/emtricitabine, EFV/TDF/FTC] in treatment-naive patients. Our intent is to start that study in the second quarter of this year.
We're also in the process of completing a study of the standalone GS-9350 tablet to boost atazanavir [ATV, Reyataz]. It's a dose-finding study to see what dose is necessary to boost atazanavir, similar to what ritonavir does in the boosted state. When those data come through, we plan to conduct a head-to-head study with the GS-9350 standalone tablet versus ritonavir to boost atazanavir -- both of those regimens, with Truvada, also on treatment-naive patients. Our goal is, pending favorable data on that PK [pharmacokinetic] study, to also start that Phase 2 study in the second quarter of this year.
John Mellors: Thank you. Robert?
Robert Guttendorf, Ph.D.
I'm very happy to have this opportunity to talk with you about our PKE [pharmacokinetic enhancer] program.2 As described, we are seeking to come up with an alternative to ritonavir as a booster in HIV therapy -- particularly with PIs, but also with potential application to other classes of antiretrovirals, and perhaps beyond.
We set out to try to address the limitations that ritonavir has, including its propensity to elevate certain lipids and its protease inhibitory activity, which could be associated. There's a risk [with ritonavir] of association with generating protease-resistant mutants, and also its GI [gastrointestinal] intolerability. We succeeded in those goals, in coming up with our lead compound, SPI-452.
It's probably worth mentioning that, if you aren't familiar with us: Sequoia Pharmaceuticals is a small, young company of only about 30 people, but we have a wealth of talent and experience at our disposal within the company, starting with our founder and CSO [chief scientific officer], Dr. John Erickson, with whom many of you are probably already familiar and who is here in the audience. Beyond that, we have breadth of experience and depth of experience across all stages of drug discovery and development and many different therapeutic elements. That allowed us to take this project from the initial inception of the PKE [pharmacokinetic enhancement] program to the full proof-of-concept demonstration in the clinic within only about three years.
As I mentioned, SPI-452 did have the profile that we were looking for in a lead candidate [according to the results of] in vitro and in vivo in animal studies. Pre-clinically, it demonstrated itself to be a very potent PK enhancer; it was on par with ritonavir. Our goal was to come up with something that was at least as good a booster as ritonavir, but which didn't have as many of the adverse aspects of the profile that ritonavir has.
Slide from SPI-452 presentation; Robert Guttendorf et al. CROI 2009; abstract 41. Reprinted with permission. Click here to view the full presentation.
In addition to that, we also built into each of these two studies an arm that would evaluate the ability of SPI-452 to enhance directed potential partner PI drugs -- saquinavir [SQV, Invirase] in the first study, atazanavir and darunavir [TMC114, Prezista] in the second study. The boosting that we saw for each of these compounds was quite remarkable and showed us beyond a shadow of a doubt that we were, in fact, hitting our molecular target and enhancing these PIs as we had hoped to do. These were on par with ritonavir, based on literature data.
With that, we believe that SPI-452 has great potential. We see it as potentially being developed as a stand-alone agent or as a fixed-dose combination. And it has potential applications not only within HIV as a PI booster, but also in HIV for other types of classes of antiretrovirals, and in HCV [hepatitis C virus] for some of the development compounds that are out right now -- it would be a very good adjunct for that. In addition to that, there are also opportunities for either 452 or our general PKE platform to be applied outside of the antiviral space.
John Mellors: Thank you very much. These are two exciting developments in the treatment field. Questions?
Reporter #1: Would you be nicer than Abbott and license your compound to other companies so that they can manufacture a combo pill?
Brian Kearney: I'd say we're currently doing work with atazanavir and are engaging in conversations with other companies to conduct pharmacokinetic studies to see if our drugs can work together. I think we've shown, with our collaboration with BMS [Bristol-Myers Squibb Company], that we're more than willing to work with other companies.
John Mellors: Dr. Guttendorf?
Robert Guttendorf: Yes, I would echo that. We, as well, are looking at the possibilities of fixed-dose combinations with this compound and are in discussions with a number of potential large pharma partners to look at directed fixed-dose combinations for development.
Reporter #2: The grade 3 adverse event of "discoordination" -- could you define discoordination for us?
Brian Kearney: This [refers to] a subject in our study who came to the investigator in the study and said that she felt like she was having a hard time engaging in juggling, which was one of the [things] she did to pass the time when she was in the clinic, and felt that [the drug she was taking in the study] impaired her ability to do that. Per the toxicity grading criteria, this was considered discoordination. It was a grade 3 event per her report, and she was discontinued from the study because we had predefined stopping rules: Anybody who had a grade 3 adverse event would be discontinued.
Reporter #2: Do you have plans to do a parallel track for releasing this as a booster on its own, or is it only in co-formulation?
Brian Kearney: No, we intend to bring forward a stand-alone tablet of GS-9350 as well as the co-formulation.
Reporter #2: Would that be around the same time?
Brian Kearney: Yes.
Reporter #3: After 20 years in this field, I am very suspicious of the phrase "safe and well-tolerated." Could you run down the side effect profile of your enhancer? What were the most common side effects?
Robert Guttendorf: Sure. I probably should qualify that, if I didn't, as generally safe and well-tolerated. I agree there is no drug out there that is absolutely safe; it is all in relative terms. In the single-dose study, the predominate adverse events were four episodes of headache and four episodes of pharyngitis -- not strep pharyngitis, just general sore throat. These are fairly typical in this type of a study, particularly as people are being withdrawn from caffeine for the study and that sort of thing; headaches tend to be pretty prevalent.
In the second study, the multiple-dose study, there were an additional number of headaches -- remember, again, this was over 15 days of dosing with four or five, plus a couple of extra days for the PI dosing before, during and after the SPI-452.
All told, with the number of subjects, we had over 1,000 dosing events, during which time there were about 35 reports of headache in 17 people. Eleven individuals reported nausea or emesis [vomiting] a total of 13 times among those 11. It was interesting that a majority of those tended to occur right before a subsequent dose was given, and it tended to be related to the fact that that's when they were getting their breakfast. As it turns out, I guess not everybody's as big a fan of French toast as I am, because that tended to be one of the prevalent findings and the timing of that finding. There were a few scattered episodes of loose stools as well.
Reporter #3: What was the maximum duration of SPI-452 dosing in your studies?
Robert Guttendorf: It was 15 days.
Reporter #4: What is known, if anything, about the interactions of your compounds with other drug classes that are metabolized by the CYP3A4 isoenzymes, like statins, macrolytes and rifamycins?
Robert Guttendorf: We have conducted several drug-drug interaction studies in vitro and, insofar as we are intending to modulate CYP3A activity, we anticipate that there will be a fair number of drug-drug interaction studies that we'll have to elucidate in the clinic. Obviously, in the HIV area, that's a risk-benefit decision that's pretty well accepted at this point in time. We will evaluate those in further studies. Our study to be done will be a CYP cocktail study, which will evaluate the direct effects of 452 on specific CYP isoforms. That will help guide us, along with additional in vitro studies, on the specific types of drug-drug interaction studies that we'll have to do to support our label.
Brian Kearney: We would expect [GS-9350] to have the same type of 3A-mediated interactions with drugs that metabolize by that pathway. We also intend to do these cocktail studies, which are now recommended by guidance to look at the different specific isoforms.
Reporter #4: In your talk, you said that [with SPI-452] there was a propensity to enhance the concentration of at the end of the dosing interval. That seems kind of unique. What kind of implications would that have?
Robert Guttendorf: The main advantage of that would be that you can enhance the levels and maintain the duration of the drug above its targeted levels. As you know, in order to maintain efficacy, you have to keep levels above this certain target level through the duration of the dosing period. As I think I've said, it has a predilection for doing that as opposed to enhancing the entire profile. In a sense, it's almost like a hinge: If you increase the back end without doing much to the front end, then we're increasing the extent of the efficacy window and not at the same time commensurately increasing the [Cmax?], which would lead to potential additional side effects.
Reporter #5: Dr. Kearney, you had indicated there's a trial [of GS-9350] starting in second quarter this year. My assumption is that you've talked with the FDA [U.S. Food and Drug Administration] and this is headed toward approval. Given that this drug is not a drug per se -- it's a little different than most others -- what are they going to be looking for in terms of duration and size of trial? What are you going to need to prove to them in order to get approval for this compound?
Brian Kearney: To answer the first part of your question, our intent is to start two Phase 2 studies in treatment-naive patients in the second quarter. One will be the quad-tablet compared to Atripla. The second, pending the pharmacokinetic data boosting atazanavir, is a study of 9350 versus ritonavir to boost atazanavir -- each of those combinations taken with Truvada, also in treatment-naive patients. We have had discussions with the FDA and plan to move forward with that in the United States in the second quarter.
Your second question: It is a new chemical entity and it is a drug by definition. Therefore it would be expected to have the same type of data as if you were developing a new antiviral. We worked with the agency and the expectation is that we will provide a safety database, as was mentioned by Dr. Kim [inaudible], who was one of the moderators of the session from FDA. We would seek to comply with that expectation that we would have a sufficient number of subjects studied for over a year -- this tends to be in excess of 500 subjects -- and a larger number of subjects studied for a shorter period of time. Our development program is based on that.
John Mellors: Just to hone in on this a little bit: Will it be sufficient to show that there is safety and equivalent exposure to elvitegravir as that which would be achieved with ritonavir boosting, or do you have to show efficacy as a quad-containing tablet that you would for any new first-line therapy?
Brian Kearney: A lot of the numbers, when you're talking about specific numbers required for approval, go into discussions about the size of the database characterizing the safety of the molecule. As you probably all know, that can be generated from multiple, different clinical studies in different combinations of drugs. That would be the case here as well.
One of aspect of the safety database will be from Phase 3 studies of the quad compared to different regimens that we would consider standard of care, one being Atripla. It's not that you have to show efficacy against all specific other combinations.
What is the definition of efficacy? It'll be defined by the individual Phase 3 studies, which will be designed in concert with the regulators.
Reporter #5: GI symptoms are a big concern for people taking ritonavir, especially diarrhea. In your proof-of-concept study, Brian, when comparing different doses of the compound with ritonavir and placebo, did you collect any data on GI symptoms? Is there any difference?
Brian Kearney: The overall rates of adverse events in those studies were low from single doses to multiple doses. There's no evidence of any dose dependence, between 50, 100, and 200 milligrams, in those studies. Not a lot of GI adverse events.
Reporter #6: Primarily for Robert, I'm wondering if you can maybe say a little bit about what your plans are to combine your drug or use it with boceprevir for hepatitis C. And Brian, if Gilead's also planning anything. Are there other disease models in which pharmaco-enhancement using this kind of compound might be useful?
Robert Guttendorf: At this point, we've shown proof of concept that we are able to enhance the levels of boceprevir [with SPI-452] in vitro, and we are conducting some animal studies now to help confirm that. Our ability to co-administer that with boceprevir is complicated a bit by the fact that it is also an NCE [new chemical entity] and in order to do that we would have to have some sort of collaboration and probably a new IND [investigational new drug application] in collaboration with the developers of boceprevir. However, we do look at that as a very good opportunity, as well as for other PIs in the HCV realm and some other HCV compounds as well.
Beyond the antiviral space, as I mentioned, our PKE platform is actually fairly broad-reaching. We have additional compounds in the pipeline that could come in as either stand-alone or fixed-dose combinations -- that have improved on some of the attributes of SPI-452 -- which could be used for HIV, HCV or elsewhere. In addition to that, we're also developing, additionally, selective PKEs for other CYP isoforms that may be able to be applied outside of the HIV space and antiviral space in general.
Brian Kearney: Our plans [for GS-9350] are most developed for the HIV program right now, but we are looking at opportunities in other therapeutic areas, including HCV.
John Mellors: Thank you very much.
This transcript has been lightly edited for clarity.
No comments have been made.
|Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.
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posted by Thom Holwerda on Mon 20th Aug 2012 22:14 UTC
"The web has been alight these past few weeks with the details of the Apple v. Samsung lawsuit. It's been a unique opportunity to peer behind the curtain of how these two companies operate, as the trial seeks to answer the question: did Samsung copy Apple? But there's actually another question that I think is much more interesting to the future of innovation in the technology industry: regardless of whether the courts say that Samsung copied Apple or not, would we all be better off if we allowed - even encouraged - companies to copy one another?" This is very relevant.


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My parents got divorced when I was ten. I have never had a good relationship with my birth mom, but there was a lady in my church who took me under her wing and has helped me through all the years. She has become like my spiritual "mom". She has been there through it all - helped me get on my...
What makes a good person? Is it how many times a day they pray? Is it how long they wait to get married? Is it how they treat others? Or is it simply being a person who loves without limits? Honestly, I don't know if it is one, two, all or none of the above. What I do know is that I...
Hey guys! We wanted to share our newest video with you for our song, "Sing Me a Love Song". Click here to watch it on Tangle. As you may know, Mercy Ministries is near and dear to our hearts. So many...
I am a very lucky person. You see, I honor two people every year on Mother's Day. I remember them both by sending them cards and notes in gratitude for all they have helped me become.
I was born and raised on a farm where my mother taught me many things. She showed me how to plant a...
You've always been good
You've mostly been great
You're never terrible
and you're never ever evil.
You love God
Like I love you
You taught me to sing
Sing from my heart
From my heart to the heavens
I know I'm the oldest
Remedy Drive Set To "Rescue" Ransom.TV on May 11th & TVU on May 14th with World Video Premiere
Four-piece rock outfit prepares to light up the summer festival circuit before first headlining tour this fall
NASHVILLE, TN / May 10, 2010 —Christian music's rising rock act, Remedy...
Satellites & Sirens Joining "Air1 Listener Appreciation Tour" As "Anchor" Climbs Charts
NASHVILLE, TN / May 7, 2010 — Known for their 80's synth pop meets rock and roll sound, Satellites & Sirens is set to make their impact on the "Air1 Listener Appreciation Tour" launching May 7...
Mother's Day is almost here. We want you to share with us things that you love about your mom, or things that you love about being a mom! Tweet your favorite memories, moments, and anything great about moms and tag @pfor #moms.
We just updated the Worship Resources section of the site with lead sheets for all the new songs! Click here to check them...
As Mother's Day approaches, I want to hear how your mother has shown and exemplified love to you and to others. Click here to share a story, and I'll be featuring them on my homepage the week of Mother's Day....


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Order today! Surface Pro 6 Surface Laptop 2 Surface Studio 2
Love my 822, but miss my palm touchstone
- I upgraded to the 822 about a month ago and really like it. Its smooth, fast and responsive a welcomed change from my aging Palm Pre Plus. The only thing I miss is using my touchstone charger. I can't bring myself to invest in new charging plates and wireless back.Looking at the 822 wireless back,it has 4 contacts instead of 2 like the pre. I would like to try and do a mod with my old pre back, but does anyone know why there are 4 on the nokia and what their polarities? The nokia battery has a positive, negative and neutral. Anyone know the details to the 4 contacts or know where to find them?01-17-2013 05:47 PM
- I miss my Touchstone too, and I have 3 of them that are now relics, but I decided it's better to bite the bullet and get the Nokia charging back and stand. I now have two stands (one for home, one for office) for one phone. The good news is that the charging works very well, more reliably than the Touchstone used to (if the Pre wasn't positioned just so, the phone would sometimes cycle on and off charge, beeping every time unless I turned off the volume). The bad news is that the screen on the Nokia doesn't stay lighted when it's on the charger the way the Pre did, so I have to hit the power button to check if there's any news. I'm hoping that there might be a software fix that would make that an option.01-19-2013 10:04 PM
- I'm not as concerned with having the screen on, I just want to be able to set it on the touchstone and charge and not have to plug it in...i got spoiled with the touchstones01-21-2013 07:49 PM
Explains why it doesn't work. Basically touchstone is proprietary wireless charging tech. Qi is a universal standard.01-21-2013 08:05 PM
- What would be interesting is to see if the coils from a Touchstone phone back could be installed in a Lumia 822 back and allow the phone to 1) stick to a Touchstone, and 2) charge off the Touchstone. I believe the difference in the standards just deals with the coils. Might require a wiring mod to make it work, but someone who has a Palm phone and an 822 could check and see if the 2 charging contacts of the Touchstone back line up with the charging contacts on the 822 (I don't believe all 4 contacts are to charge, but I'm not sure - if anyone has the tech specs on this stuff, I could tell you pretty quickly).01-23-2013 08:06 PM
- The tech spec sheet is what I can't seem to find. I don't even know where to get one. I tried using a multimeter to figure out what the four prongs do, but I don't think I was able to figure anything out. I ordered some conductive copper tape to see if I can do some sort of mod with the coil from my pre. I'll have to see if I can get some time this weekend to play with it.01-30-2013 08:34 AM
- Looking at the pictures of the phone, it looks like there are 4 contacts on one side and a pair on the other. The wireless charging cover appears to mate with the single pair on the left side of the phone when looking at it's battery compartment (right side of phone when looking at display), which means the 4 contacts on the other are probably for something else, such as NFC or some factory use. It looks like a Touchstone wireless receiving coil from a Pixi would actually be the better coil to use as the contacts would be roughly near, and wide enough to put some contact foil or wire coming in from the contacts. It's also thinner than the one from the Pre covers. I would imagine that the Touchstone coils will be the correct winding ratio, assuming Qi and Touchstone charge with the same rough voltages/currents (I would guess yes, as I would assume they would present a charging source, to the device, that looks the same as one coming off a USB charger - would simplify the design as there would be no need for further regulation/conversion).
If a Touchstone coil mod works on these phones, that would be great news for those of us running around with a bunch of Touchstones, especially since I would be able to plunk the phone down onto the one in my car and it would stay there due to the magnets in the coil set for Touchstone backs. I won't be able to find out until later in March, so good luck to anyone willing to try. If it works...please share.02-01-2013 10:09 PM
- Well I have been playing with trying the mod and trying to find out the polarity of the four contacts. Here are my voltage results using a multimeter with the phone turned on. The (+) and (-) are from the multimeter and I labeled them based on where I placed the (+) lead from the multimeter. Their position also correlates to contacts/leads of the phone (top-down):
Contact 1
(-) = -0.0
(-) = -1.7
(-) = -0.0
Contact 2
(-) = -0.0
(-) = -1.8
(-) = -0.0
Contact 3
(-) = 1.7
(-) = 1.7
(-) = 1.7
Contact 4
(-) = -0.0
(-) = -0.0
(-) = -1.8
Does anyone know about electricity and can help understand these results?
pmhgeneral likes this.02-08-2013 12:57 PMLike 1
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- Those voltages aren't standard for a Lith-Ion. As I mentioned above, I believe those 4 contacts are not the wireless contacts. I believe (from screen shots of the back of the phone and the wireless charging backs) that there are 2 contacts on the opposite side of the phone that are the ones used for the wireless charging. Take a look at your phone back again and see if there is a set of 2 contacts across the back from the 4 contacts.
I can't really tell anything from the measurements you did make, though, being a test engineer, I can tell you that a lot of dense devices, such as DSP's, CPU's, and FPGA's use 1.8V for their supply voltages (the other common one is 3.3V). Typically, the Li battery will supply somewhere between 3.4-4VDC, which will then be regulated to 3.3V and 1.8V to power the various devices on the phone's PCB, as well as driving the display and radios.02-12-2013 06:17 PM
- Those voltages aren't standard for a Lith-Ion. As I mentioned above, I believe those 4 contacts are not the wireless contacts. I believe (from screen shots of the back of the phone and the wireless charging backs) that there are 2 contacts on the opposite side of the phone that are the ones used for the wireless charging. Take a look at your phone back again and see if there is a set of 2 contacts across the back from the 4 contacts.
Last edited by wingman7000; 02-12-2013 at 10:03 PM.02-12-2013 09:24 PM
- Well, I'll be able to get mine in a little over a month. I can experiment then. At this point, my best guess is the middle two contacts. Direction shouldn't matter since coils transfer power by alternating the direction of current flow back and forth at whatever frequency they are designed to do it at (I would imagine the TouchStone and Qi chargers are 60Hz). You could probably put a touchstone back onto a touchstone and tape a wire to each contact(EDIT: May be best to wire first...then place on touchstone...for safety sake!), then touch or tape the wires to the middle two contacts on the phone and see if it starts charging. The coils in the touchstone backs are designed to match up to the coils in the touchstones, as the Qi chargers are similarly matched. So it should provide proper power for charging the batter at that point.
If you have, or can get, one of the 822 wireless charger backs, you can place it on a touchstone and see which two contacts are generating current, which would make this less of a guess. I can't really do more until I have a phone in hand.02-14-2013 08:43 PM
- After messing around, this is what I know. The Touchstone backs put out a 5VDC charge, probably to match USB charging at around 500mA, probably around 50% effeciency. The spec that I can get without signing up, shows Qi is 5W at up to 70% efficiency. So that would put the numbers in the same ballpark of 5VDC and around 700mA max, within the USB spec, and likely closer to 500mA regulated. I would guess that the differences between the two specs is primarily the turns ratio, which is why placing a Lumia, w/charging back, on a Touchstone will indicate charging, but probably doesn't pull enough current to actually charge. I'm betting a Touchstone back coil will work with the Lumia, but the question is what contacts need to be hooked up to.
The Lumia has 4 contacts, instead of two, for the wireless charging. I suspect that the "extra" contacts are for either 1) current (2 smaller wires to handle the current of one larger one) or 2) for feedback for regulators. They could also be dummies, or have some other communication use for communicating with charging bases like the new HP stuff was going to do with the new version of Touchstones. What I would need is to see what the voltages are, pin to pin, for the 4 contacts of a Qi wireless Lumia back when it is placed on a Qi wireless charging base, sans the phone. This way, it would be easy to see what voltages it supplies - the rest is easy. So if anyone has one, and wants to put the information out there, I'll use it, and verify it, with my Lumia 822 I got off ebay (I'm still getting a free one from VZW at the end of the month, so I can experiment a little). I've also found out that the backs for the Pre's have 4 metal discs that are use to hold the phones to the magnets on the Touchstones. The 4 discs are place to where 4 corners where they would orient around the Touchstone, like a circle, allowing for the centering and multiple orientations. You need more than these 4 discs with the white Lumia because of the slickness of the back. I suspect the matte finishes will stay on, and I suspect this is why all of the Touchstone backs were matte. If not, simply adding 4 more discs, in alignment with the circular magnet of the Touchstone, will likely get it done, slick back or not.
Whew!!03-05-2013 08:43 PM
- I don't have a wireless charging back for my 822, or I would have it figured out already. I highly suspect it's a two wire per pole charging system to handle current and/or kelvin feedback. If someone has a wireless charger and DMM and can tell me the voltages, contact to contact, I can figure it out. The biggest problem is really going to be getting the phones to stay on the Touchstone. I added the 4 small metal discs from the extra Pre+ touchstone charging back I had to the inside of the batter cover. The phone will center on the touchstone and stay there, but barely. Need a metal ring to really get the magnetic seal to hold the phone. Of course, a matte back would work better than the glossy cover I have.04-19-2013 10:28 PM
- Re: getting the phone to stay on the Touchstone, people have used these magnets (K&J Magnetics - Products) when modding the Galaxy S3. I ordered a Touchstone back for my S3 (Amazon.com: Wireless Charging Back Cover/Back Door ONLY for Samsung Galaxy S3 I9300 , Marble White; A Separate Palm Touchstone Charging Set (including Dock, Adapter and USB Cable) is Needed!: Cell Phones & Accessories) and it is soft touch. That plus the magnets they added hold it to the touchstone nicely.04-30-2013 10:12 AM
- Here's the thread over on AC re: Touchstone mod for Galaxy S3: http://forums.androidcentral.com/t-g...ne-mod-s3.html. Has some detail about the magnets and taping the charging coils down, etc. I imagine some of that could translate to the 822.04-30-2013 10:14 AM
- Use magnets with caution - there have been cases of strong magnets damaging the compass in the phone.
I personally use a case that has a magnetic closure, and haven't had any problems that I've noticed (unless that's why Photosynth always wants to calibrate before I can use it), but that doesn't mean it can't happen.04-30-2013 12:26 PM
- Use magnets with caution - there have been cases of strong magnets damaging the compass in the phone.
I personally use a case that has a magnetic closure, and haven't had any problems that I've noticed (unless that's why Photosynth always wants to calibrate before I can use it), but that doesn't mean it can't happen.
I plan to pull the coils off a Pixi and see what I can do with the 822.05-01-2013 09:21 AM
- Sorry I haven't responded to this thread (been gazing at the 928 thread since I still have my upgrade available too me). The thread in question involves phones that use 2 contacts, like the Pre and Pixi, to wirelessly charge. The Lumia uses 4. If they simply are pairs for current handling, no problem, but I still need to know which ones pair together. The magnets link is good. Don't know if I'm going to get this done or not. I need a wireless shell and I'm not going to buy one if I switch to the 928.05-22-2013 05:02 AM
- Unfortunately I pretty much gave up on converting my palm charger to the 822. It's been too busy for me to be able to sit down and play with it anymore and it was driving me crazy that it wasn't working for with all the combos I tried.05-23-2013 05:55 AM
Oh well. If anyone get's me the voltages from the wireless back itself (not the phone) so I can figure the pin out, I can at least guide people on how to do it. Until then, I don't see this happening anytime soon.05-23-2013 08:18 PM
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Updated 5 PM ET: While the core of this render is accurate, the screen itself was created by one Florin N. who tipped us that this is not a new "leak". Still, the 1320 vs 929 info is accurate.
A new render of the Nokia Lumia 929 has been leaked on the Chinese micro-blogging website, Weibo. The render is the same as we've seen previously from other accounts, but details have also emerged that we could well be looking at the Lumia 1320 for regions outside the US. Nokia is set to unveil numerous handsets and other hardware at its Nokia World event in Abu Dhabi later this month.
Codenamed "Batman," the Lumia 1320 would be positioned in between the Lumia 1020 and Lumia 1520 Windows Phones. Offering consumers a clear choice with multiple screen sizes, it would make sense for Verizon's Lumia 929 to be launched outside the US under a different name. We could well be looking at another Lumia 909 and Lumia 1020 situation here.
[Correction: Tom Warren from the Verge thinks the 'Batman' phone is something other than the Lumia 1320].
What we do know is Verizon will be looking to launch the Lumia 929 in early November for the off-contract price of $500. Sporting a display size in the 5-inch range, the Lumia 929 / Lumia 1320 would be a welcomed addition to the Windows Phone family by those who wish to have a larger handset than the 1020, but not as monstrous as the Lumia 1520.
We'll have more details at Nokia World.
Source: Twitter (Ctechcn)


text:
Great Lakes Week begins in Milwaukee
Great Lakes Week begins in Milwaukee
Great Lakes Week kicks off in Milwaukee on Monday.
The event focuses on pollution cleanup and habitat restoration in the Great Lakes.
Industrial, environmental and government leaders will meet alongside tribal members.
They are scheduled to meet with many groups, including the council of Great Lakes industries.
Some will tour the Sheboygan River and Harbor on Monday to see the cleanup and restoration work that's been done.
Milwaukee Mayor Tom Barrett says Congress is proposing between 30 and 75 percent cuts in the funding for Great Lakes, but that federal funding has been instrumental in improving the quality of the world's largest source of fresh water over the past 40 years.
The event runs until Thursday.


text:
Do you ever consider the level of complexity
that goes into planning the route your bus takes while transporting you to
class in the morning or taking you home from work at night? Alicia Becker does.
In fact, it's her job to design more efficient routes for public transit, and
address any weather, traffic, and train roadblocks that arise.
Becker, who graduated in December 2012 with a
degree in public planning, originally focused her studies on engineering. It
wasn't until she enrolled in an Introduction to Planning course that she
uncovered her passion to work in city management and planning.
As a public planning major, Becker worked on a
variety of projects that served to further her education while helping improve the
local community. But her senior-year internship with the Northern Arizona
Intergovernmental Public Transportation Authority (NAIPTA) gave her the best
chance to choose her career path within the public planning field.
"With public planning, there are
so many different areas," Becker says. "I knew I was interested in
transportation, so my professor connected me with the planning manager at
NAIPTA. That's when I knew transportation was the road I wanted to go down."
During her nearly yearlong internship, which was
sponsored through the Paul S. Sarbanes Transit and Parks Program Grant, Becker
worked to create a more rider-friendly bus system for Flagstaff. The challenges
it posed helped her find innovative ways to optimize Flagstaff transportation
while honing her skills for her future career.
"We took into account population density, where
the commercial activity centers are, and how the system interacts with Northern
Arizona University." Becker says. "It was all about creating routes for the
near future as well as the long term. We even worked with the Forest Service to
plan an alternative transit system."
Her hard work as an intern paid off; Becker was
eventually promoted to associate planner, which gave her more responsibility
and more interaction with primary stakeholders from the region, including the
university. She says analyzing the comments that NAIPTA received through its
public outreach efforts enabled her to gain a broader perspective of the
Flagstaff community's mindset toward transportation.
In her new role, Becker conducted research on
how to improve Route 10, which runs through Northern Arizona University and
surrounding areas. It was Becker's responsibility to analyze data and find more
efficient ways to accommodate Route 10's largest group of passengers, which
include students, faculty, and staff.
"There were a whole bunch of problems with that
route because half the time, you couldn't fit all the riders on the bus at the
stops," Becker says. "The trains really slow it down too. So I had to figure out a way to adjust the
schedule when buses left certain points to make the route more productive."
For her work both in and out of the classroom,
Becker recently received the Public Planning Student Excellence Award from the Department of Geography, Planning, and Recreation (GPR). Though she admits working with full-time faculty helped
expand her knowledge, Becker also believes that learning from adjunct
professors, some of whom serve in roles with NAIPTA, provided a different type
of educational experience that was just as valuable to her.
Says Becker, "There was a lot of interaction
with the adjunct professors, and hearing about their experiences provided
something you can't learn in a textbook. I got to hear a lot of real-life
stories about what they were working on."
Becker is now set to work with Valley Metro in
Phoenix, a "dream" position where she can apply her education and professional
experience. Becker believes her experiences both in and out of the classroom
have prepared her for the next stage of her life and taught her the importance
of making the right connections.
"Northern Arizona University has really helped
me find out what I want to do and how to get there," Becker says. "I was
introduced to a lot of people, and realized how vital it was to make
connections with professionals. The university is very well connected in that


text:
|MLB Career Stats
|13th in NL
|25th in NL
|24th in NL
|20th in NL
|4th in NL
|7th in NL
|25th in NL
|13th in NL
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|7th in NL
|25th in NL
|25th in NL
|25th in NL
|12th in NL
|20th in NL
|12th in NL
|9th in NL
|6th in NL
|19th in NL
|12th in NL
|21st in NL
|11th in NL
|18th in NL
|22nd in NL
|20th in NL
|23rd in NL
|20th in NL
|24th in NL
|25th in NL
|7th in NL
|13th in NL
|10th in NL
|21st in NL
|8th in NL
|4th in NL
|16th in NL
|17th in NL
|19th in AL
|March 15, 2016
|DH Adam LaRoche retired.
|November 25, 2014
|Chicago White Sox signed free agent DH Adam LaRoche.
|October 31, 2014
|1B Adam LaRoche elected free agency.
|May 25, 2014
|Washington Nationals activated 1B Adam LaRoche from the 15-day disabled list.
|May 23, 2014
|Washington Nationals sent 1B Adam LaRoche on a rehab assignment to Harrisburg Senators.
|May 22, 2014
|Washington Nationals sent 1B Adam LaRoche on a rehab assignment to Potomac Nationals.
|May 11, 2014
|Washington Nationals placed 1B Adam LaRoche on the 15-day disabled list retroactive to May 10, 2014. Strained right quad.
|January 8, 2013
|Washington Nationals signed free agent 1B Adam LaRoche.
|November 3, 2012
|1B Adam LaRoche elected free agency.
|October 31, 2011
|Washington Nationals activated 1B Adam LaRoche from the 60-day disabled list.
|September 3, 2011
|Washington Nationals transferred 1B Adam LaRoche from the 15-day disabled list to the 60-day disabled list.
|May 23, 2011
|Washington Nationals placed 1B Adam LaRoche on the 15-day disabled list retroactive to May 22, 2011. torn labrum in left shoulder
|January 7, 2011
|Washington Nationals signed free agent 1B Adam LaRoche.
|November 7, 2010
|1B Adam LaRoche elected free agency.
|January 15, 2010
|Arizona Diamondbacks signed free agent 1B Adam LaRoche.
|November 5, 2009
|1B Adam LaRoche elected free agency.
|August 1, 2009
|1B Adam LaRoche assigned to Atlanta Braves.
|July 31, 2009
|Atlanta Braves traded 1B Casey Kotchman to Boston Red Sox for 1B Adam LaRoche.
|July 22, 2009
|Boston Red Sox Traded SS Argenis Diaz to Pittsburgh Pirates; Pittsburgh Pirates Traded 1B Adam LaRoche to Boston Red Sox and Greenville Drive Traded RHP Hunter Strickland to West Virginia Power.
David Adam LaRoche...was twice drafted by the Marlins as a pitcher, but did not sign (18th round in '98, 42nd round in '99)...instead, pursued career as a position player...younger brother, Andy (.226 career hitter with 22 home runs and 113 RBI entering 2012), last played in the big leagues for the the Athletics in 2011...the LaRoche brothers were teammates with PIT in 2008 and for a portion of '09...father, Dave, was a 2-time AL All-Star (Indians in '76, Angles in '77) who finished 65-58 with a 3.53 ERA in 647 games/15 starts spanning 14 seasons with CAL, MIN, CHI, CLE and NYY.2015
Batted .207 (89-429) with 12 home runs and 44 RBI in his first season with the White Sox. ... His average was a career low, and his totals in games, hits, homers and RBI were the lowest since 2004 (rookie season). ... Hit .221/.318/.379 with 12 home runs and 37 RBI vs. RHP and .157/.191/.383 with zero homers and seven RBI vs. LHP. ... Appeared in 48 games (44 starts) at first base and recorded a .997 fielding percentage (1 E/378 TC), his highest in a full season since 2009 with Atlanta (.998). ... Batted .238 (38-160) with eight doubles, eight home runs, 20 RBI and a .746 OPS as the first baseman and .186 (49-263) with 13 doubles, four home runs, 21 RBI and a .560 OPS as the designated hitter … went 1-7 (.143) with two RBI as a PH. ... Hit nine of his 12 home runs in the first half … recorded monthly highs in average (.270), hits (24), RBI (13), runs scored (11) and OPS (.847) over 28 games in May. ... Went 0-4 in his White Sox debut as the designated hitter on Opening Day at Kansas City … doubled off Danny Duffy on 4/8 at Kauffman Stadium for his first hit with the Sox. ... Connected on his first homer (solo shot) with Chicago on 4/11 vs. Minnesota … also homered on 4/12 vs. the Twins. ... Walked three times on 4/15 at Cleveland for the 10th time in his career … went 3-5 with four RBI, including a three-run home run off Anibal Sanchez, on 4/18 at Detroit. ... Reached base safely in 13 consecutive games from 5/1-16 … hit .324 (12-37) with two doubles, one home run, seven RBI and 13 walks during the stretch. ... Did not record an extra-base hit or homer over a span of 17 games from 4/19-5/9 … recorded a double on 5/10 vs. Cincinnati … snapped his 19-game homerless drought on 5/13 at Milwaukee with a solo shot in the first inning … the stretch was his longest without a home run since 8/18-9/9/13 (also 19). ... Recorded three straight multihit efforts from 5/26-28-1 and drove in at least one run in three straight from 5/27-28-2. ... Connected on a game-tying, solo home run with two outs in the bottom of the ninth inning on 6/5 vs. Detroit … Chicago went on to win, 4-3, in 11 innings … hit a game-tying home run in the sixth inning on 6/10 vs. Houston. ... Matched his career high with four hits on 7/31 vs. the Yankees … also made his first career pitching appearance in the ninth, working a perfect inning with a strikeout (Brendan Ryan). ... Became just the sixth player since at least 1914 to record four hits and pitch in relief in a game … the others are Shane Halter (2000), Johnny Gorsica (1941), Carl Mays (1929), Rosy Ryan (1925) and Casey Hageman (1914) … source: STATS. ... The last White Sox to pitch in a game and record four hits was Early Wynn on 6/4-1/59 at Baltimore. ... Did not homer in July, his first homerless month since May 2011 … connected on a solo homer in the ninth on 8/7 at Kansas City, snapping a career-long, 33-game homerless stretch. ... Forced extra innings with a RBI groundout in the ninth inning on 8/22 at Seattle … White Sox went on to win, 6-3. ... Went 2-4 with two RBI, including his final home run of the season, on 8/23 at Safeco Field. ... Appeared in just nine games from 9/1 through the end of the season due to tendinitis in his right knee. ... Recorded his final multihit game on 9/1 at Minnesota, and final RBI on 9/6 at Kansas City.2014
National League Leaders: 2nd in PA/BB (7.2); 3rd in AB/RBI (5.37); T3rd in GW RBI (17); 4th in AB/HR (19.0); T5th in RBI (92); 7th in HR (26)...Reached the 20-home run plateau for the third straight season and ninth time overall … hit 25-plus homers for the sixth time and drove in 90-plus runs for the fourth time...Led the Nationals with 26 home runs and 92 RBI … his 82 walks and .362 on-base percentage were both career highs...Was a finalist for the NL Gold Glove Award at first base after recording a .994 fielding percentage (7 E/1,200 TC)...Batted .280 (100-357) with 21 homers, 76 RBI and a .501 slugging percentage vs. right-handers … ranked among the NL leaders vs. RHP in on-base percentage (3rd, .390), RBI (T4th), home runs (T6th), and OPS (10th, .891)...Hit safely with a RBI in each of the first three games … homered in the Nationals Opening Day win at the Mets...Compiled a 10-game hitting streak from 4/16-26 (.361, 13-36)...Recorded a RBI in each of the last five games of the streak...Was on the Nationals disabled list from 5/11-25 with a strained right quad, including injury rehab assignments at Class A Potomac and Class AA Harrisburg...Recorded three straight multihit efforts from 6/22-24 and 9/7-9 … drove in a run in four consecutive games from 6/27-30...Registered three straight multiRBI efforts from 8/14-16...Posted multihomer games on 8/6 vs. the Mets and 9/7 vs. Philadelphia, upping his career total to 24...Tied for third in the NL with 22 RBI in September … reached the 25-homer mark on 9/19 at Miami...Hit a game-tying, pinch home run in the ninth inning and a game-winning single in the 13th as part of a five-RBI effort on 9/3 at Dodger Stadium … the pinch homer was the first of his career...Did not start due to back soreness and a bruised elbow...Walked a career-high four times on 9/12 at the Mets...Played in all four games of Washington's four-game, NLDS loss to San Francisco, including all 18 innings at first base in a Game 2 loss2013
For 8th time in last 9 years, reached the 20-homer plateau...posted highest walk rate (BB/8.19 PA) of career...hit 200th career HR, a 3-run shot, in 7-6 win, April 20 at NYM...hit solo homer in 15th inning to lift Washington to an 8-7 win, Aug. 17 at ATL, in longest game (5:29) in Nationals' history...batted .382 with 2 doubles, 4 homers, 12 RBI and 9 walks during career-high 16-game hit streak from May 2-19...homered twice in a 10-inning, 6-5 win on May 17 at SDP to become the first opposing player to hit 10 career homers at cavernous Petco Park, which opened in 2004.2012 In fantastic 2-way campaign, led MLB first baggers with 33 homers and 69 extra-base hits and earned initial Silver Slugger and Gold Glove citations of career...joined 2B Robinson Cano (NYY), 3B Chase Headley (SDP) and OF Andrew McCutchen (PIT) as only players to win both a Silver Slugger and a Gold Glove in '12...tied for 6th (NYM's David Wright) in National League MVP voting (86 points)...with 33-homer, 100-RBI effort, joined Ryan zimmerman ('09) & Adam Dunn ('09-10) as only Nationals to reach 30-homer and 100-RBI plateaus in the same season...recorded career highs in hits (155), homers, RBI (tied, 100), go-ahead RBI (29) and game-winning RBI (15)...uncharacteristically thrived offensively (.329, 4 HR, 17 RBI) in April (had entered '12 with .208 career mark in March/April)...defensively, led all NL first baggers in fielding percentage (.995), games started (149) and innings (1323.1)...at 6.1, also paced NL first basemen (min. 1000 innings) in Ultimate zone Rating and 38 plays made out of zone (OOz)... pocketed 1,000th career hit in a 7-4 victory, May 16 vs. PIT...homered in a career-best 4 consecutive games from Sept. 3-6 vs. CHI. 2011 Played in only 43 games, none after May 21, after electing for season-ending surgery, performed by Nationals Medical Director Dr. Weiemi Douoguih, on June 16 to repair a torn labrum in left shoulder ... went on DL on May 23, retroactive to May 22, and didn't play thereafter ... snapped 3-3 deadlock with decisive two-run homer in the 11th inning of 5-3 win, April 7 at FLA ... May 6, lifted game-winning sac fly in 10th inning of a 3-2 victory at FLA ... when placed on DL (May 22), led club with 25 walks ... played flawless defense (no errors/412 total chances) at first base. 2010 In lone season with ARI, reached the 100-RBI plateau for the first time in finest offensive season to date...hit .261 with 37 doubles and 25 home runs and exactly 100 RBI in 151 games...89 of the 100 RBI came as a first bagger and established a franchise record for the position...posted career-best 26 go-ahead RBI, and matched career mark with 10 game-winning RBI...in Edwin Jackson's no-hitter, provided game's lone run via 2nd-inning solo shot off Jeff Niemann...posted career-high 6 RBI, Aug. 1 at NYM...on Aug. 11 at MIL, hit first of ARI's 4 consecutive home runs (Miguel Montero, Mark Reynolds and Stephen Drew followed suit), which matched a big league record...homered into McCovey Cove on Aug. 27 at SFG off Tim Lincecum. 2009 Over 3 stops with the Pittsburgh Pirates, Boston Red Sox and Atlanta Braves, collected a career-best 154 hits...Was one of four players in the last 10 years to hit at least one home run for three different teams and for at least one team in each league...Tied for 10th in the Majors with 11 home runs in the 7th inning or later...In the NL, his .333 home batting average ranked fifth...In 76 home games, hit .329 (93-for-283) with 26 doubles, 1 triple, 15 home runs and 44 RBI...Homered in back-to-back games on Sept. 13 @ Cardinals and Sept. 15 vs Mets...in the latter game hit 2 homers and set a career high with 4 runs scored...Had a season-high 8-game hitting streak from May 27-June 6, batting .407 (11-for-27) with 5 doubles, 2 home runs and 7 RBI...Had his third and fourth career stolen bases on June 8 @ Braves and June 24 vs. Indians...Traded on July 22 to the Pirates for minor leaguers INF Argenis Diaz and RHP Hunter Strickland...Traded on July 31 to the Braves with cash considerations for INF Casey Kotchman...In 57 games for the Braves, batted .325 (69-for-212) with 12 home runs and 40 RBIs...In 27 games in August, hit .365 (35-for-96) with 8 home runs. 2008 Made 129 appearances (128 starts) at first base in second full season with Pittsburgh...Ranked fifth in the league with a .993 fielding percentage; made eight errors (six fielding/two throwing) in 1219 total chances...Ranked second on club in home runs (Nate McLouth led with 26)...Hit .318 in his last 74 games (beginning on 6/14), going 85-for-267 with 19 doubles, 19 home runs and 60 RBI...His .318 average from 6/14 thru the end of the season was the sixth-best mark in the N.L...Was the Opening Day starter at first base for second straight season...Had hits in each of his first two at bats, but then went hitless in next 25 at bats...Snapped career-high 0-for-25 streak with a home run off Chicago's Kevin Hart on 4/9...Went 4-for-32 in next 10 games after hitting homer, but hit safely in six of his last seven games in April...Went deep in back-toback games on 5/4 and 5/6...Swiped lone base (second career) on 5/10 vs. Atlanta...Had a three-run double in the top of the 10th inning in club's 8-4 10-inning win on 5/13 at St. Louis...Hit safely in six straight games from 5/21-27 (11-for-26, .423), but then went hitless in 18 straight at bats from 5/30 to 6/4...Served as designated hitter on 6/14 at Baltimore and hit two-run homer off lefty George Sherrill in 9th inning to give Pirates 7-6 lead (Bucs lost the game 8-7 in the bottom of the 9th)...Singled off Sherrill the following day, knocking in the game-winning run in the 10th inning...Had three hits, including third career triple, on 6/24 vs. New York (AL)...Went 7-for-13 in four-game stretch from 6/28 thru 7/1, raising average from .220 to .235...Reached base safely in all four plate appearances on 7/7 vs. Houston and tripled for third time in past 12 games...Homered on 7/8 vs. Houston - his first at PNC Park since 5/12 (game one)...Went deep again on 7/12 vs. St. Louis; also left game in 9th inning with a right thumb contusion...Hit safely in season-high nine straight games from 7/11-23, going 13-for-34 (.382) with two homers and six RBI...Homered twice on 7/25 vs. San Diego - his eighth career two-homer game...Homered again the following night vs. San Diego...Batted .390 in July, the second-highest mark in the league behind New York's Fernando Tatis (.397) among players with at least 60 at bats...Left game on 7/27 was placed on the 15-day disabled list on 7/29 with a right intercostal strain...Began a rehab assignment with Class-A Hickory on 8/11 and homered that night vs. Greensboro...Went 6-for-10 in three games with Crawdads...Was recalled from rehab assignment and reinstated from the D.L. on 8/14...Went hitless in first game back on 8/14 vs. Cincinnati, but followed that with three hits vs. New York Mets on 8/15...Hit game-tying home run on 8/18 vs. New York (Pirates won the game 5-2)...Was ejected by Bob Davidson for arguing strike call at Milwaukee on 8/25...Went hitless in 16 straight at bats from 8/26 to 9/3; snapped streak with two-hit performance at Cincinnati on 9/3...Went 11-for-25 (.440) with five multi-hit games in seven-game span from 9/3-10, raising average from .259 to .269...Doubled in five straight games from 9/5-10 and tallied eight doubles in nine games from 9/5-14...Was caught stealing second base on 9/15 vs. Los Angeles (NL)...Homered twice for the ninth time in his career, hit third career grand slam and had career-high tying five RBI against the Dodgers on 9/17...Left game on 9/21 vs. Houston with tightness in left hamstring...Missed just one game and returned to action on 9/24 and homered at Milwaukee...Also went deep in final game of season on 9/28 at San Diego; a 446-foot blast which was the longest at the park in 2008 and is the fourth-longest in PETCO Park history...Batted .321 with a team-high seven home runs in September and ranked fourth among National League players with 26 RBI during the final month. 2007 Spent first season with Pittsburgh...Led club in RBI and games played and shared lead in doubles with Freddy Sanchez...Established career highs in at bats, hits and doubles...His 42 doubles tied with Colorado's Todd Helton for third among National League first basemen behind San Diego's Adrian Gonzalez (46) and Chicago's Derrek Lee (43)...His 21 home runs were the most by a Bucco first baseman since Kevin Young hit 25 in 1999...Made career-high 151 appearances (148 starts) at first base and committed six errors (five fielding/one throwing)...His .996 fielding percentage ranked second behind Helton's .999...Led league first basemen with 154 double plays...Batted .328 (96-for-293) in his last 77 games; the 12th-highest average in the N.L. beginning on 6/28...Was the Opening Day starter and went 0-for-5 with four strikeouts in Houston on 4/2...Went hitless in his first eight at bats before going 1-for-4 on 4/4...Struck out 13 times in his first 24 at bats thru 4/8...Hit first home run as a member of the Pirates on 4/7 at Cincinnati and went 2-for-4 in the contest - his only multi-hit game in 27 games thru 5/4...Had three RBI while taking Adam Wainwright deep at St. Louis on 4/17...Committed first error on 4/16 at St. Louis; snapping his 49-game errorless streak dating back to 8/14/06...Was batting .191 following the action on 5/25; hit .303 (123-for-406) from that point on...Batted .459 (17- for-37) with six doubles, five home runs and 12 RBI while hitting safely in nine straight games from 6/27 thru 7/5...Homered twice for seventh career time on 7/5 vs. Milwaukee...Batted .321 (25-for-78) during the month of July; ranked third among N.L. first basemen with a .526 slugging percentage and fourth in batting average for the month...Recorded first career stolen base on 8/4 vs. Cincinnati...Tied career high with four hits on 8/8 at Arizona...Became first Pittsburgh player and 15th opposing player to reach McCovey Cove with his blast off Tim Lincecum at AT&T Park on 8/11...Produced second nine-game hitting streak from 8/13 (game two) thru 8/21 (17-for-36, .473)...Had season-high four RBI on 8/24 at Houston...Went a season-high 47 games without an error from 7/14 thru 9/7 (416 chances)...Tied season high with third nine-game hitting streak from 9/4-14 (14-for-36, .389)...Homered once in final month (9/5 at St. Louis) and tallied just eight RBI in 24 games in September...Was the recipient of the Chuck Tanner award, presented by the Pittsburgh chapter of the BBWAA to recognize the Pirates player whose professionalism, cooperation and availability best assist the writers in carrying out their daily responsibilities. 2006 Spent second straight full season with Atlanta and established career highs in every offensive category. ...Ranked second on the club in home runs (Andruw Jones led with 41) and fourth in RBI...Tied for eighth among all National League players with 57 RBI on the road...Became just the third Braves first baseman to hit 30+ homers in a season (also Fred McGriff with 34 in 1994 and Andres?Galarraga with 44 in 1998)...Hit 21 of his 32 home runs on the road...Batted .323 (74-for-229) with 19 homers, 49 runs scored and 48 RBI in 66 games after the All-Star?break...Tied for sixth among N.L. players with 19 home runs after the break...Made 142 appearances (130 starts) at first base and committed just five errors...Ranked fourth among National League first basemen with a .996 fielding percentage...Hit a three-run homer in the 1st inning on Opening Day at Los Angeles (NL)...Went 3-for-5 and established a career high with five RBI on 5/19 at Arizona; connected off Miguel Batista for second career grand slam in 1st inning...Smacked two home runs on 5/28 at Wrigley Field...Hit first of seven home runs off a left-handed pitcher on 6/17 at Yankee Stadium (Ron Villone)...Had two home runs and tied career high with five RBI in 15-12, 11-inning victory at San Diego on 7/14...Went 4-for-4 with a homer, three RBI, three runs and a double on 7/17 at St. Louis...Went 4-for-4 with three doubles and a triple on 8/30 vs. San Francisco, becoming the first Atlanta Brave (since 1966) to go 4-for-4 with all four hits going for extra bases...His fourth and final two-homer game - and third since the All-Star break - came at Pittsburgh on 8/1...Produced career-high 11-game hitting streak from 8/21 thru 9/2; batted .525 (21-for-40) with three home runs, 12 runs and 14 RBI during the streak. 2005 Spent entire season with Atlanta...Made 125 appearances (117 starts) at first base...Hit 19 of his 20 home runs off right-handed pitchers...Connected off Jeff Weaver at Dodger Stadium for first career grand slam on 5/13...Also homered in next game on 5/15 at Los Angeles...Hit safely in season-high seven straight games from 6/19-27 (8-for-23, .348)...Had second career multi-homer game on 7/4 vs. Chicago (NL)...Hit lone homer off a lefthander on 7/4 (Will Ohman)...Matched career high with four hits on 8/19 vs. San Diego...Snapped career-worst 0-for-22 slump with a 6th-inning single on 8/27 vs. Washington...Produced fourth career four-hit game on 9/17 at New York (NL), which included a two-run homer in the 1st inning...Had four RBI on 9/21 vs. Philadelphia...Batted just .105 (6-for-57) with no homers and three RBI in 19 games from 8/20 to 9/13, but rebounded to hit .385 (20-for-52) with five home runs and 10 RBI in final 17 games...Homered in back-to-back games on 9/26 and 9/27 (both in Colorado)...Went 4-for-8 in three games during the N.L. Division Series against Houston and led Braves with six RBI...Went 1-for-1 with a double and two RBI in Game 2...Hit his first career postseason grand slam in the 3rd inning of Game 4 off Brandon Backe, becoming the first Braves player to hit a postseason grand slam since Andres Galarraga on 10/11/98 at San Diego in Game 4 of the N.L.C.S. 2004 Spent rookie campaign with Atlanta...Missed 31 games with a separated left shoulder...Was named to the Topps Rookie All-Star Team...Ranked third among N.L.?rookies in slugging percentage (.488) and fifth in doubles...Hit .302 with 10 home runs after the All-Star break, which included a .348 (23-for-66) mark in September...Hit 12 of his 13 home runs off right-handed pitchers...Made major league debut on 4/7 vs. New York (NL) and collected his first two hits in the Braves' 11-run 4th inning...Became first National League rookie and just the fourth in major league history to collect his first two hits in the same inning during his major league debut...Singled off Steve Trachsel for first big-league hit and followed that up with a double off Grant Roberts...Connected off Aaron Harang for first major league home run on 4/21 at Cincinnati...Had first career four-hit game and tied a major league record with four doubles on 5/15 at Milwaukee (was the 44th time it had been done and the 22nd in the N.L.)...Separated his left shoulder on 5/28 at Philadelphia in a collision at home plate with catcher Mike Lieberthal...Was activated from the disabled list on 7/2 following a four-game injury rehabilitation stint at Richmond (AAA)...Recorded first career multi-homer game on 8/11 vs. Milwaukee...Tallied game-winning RBI single off Los Angeles' Eric Gagne in the 9th inning on 8/19...Banged out six doubles during season-high six-game hitting streak from 8/26 to 9/4 (11-for-22, .500)...Hit first career triple in the 7th inning on 9/17 at Florida...Homered in consecutive games for the first time on 9/28 and 9/29 vs. New York (NL)...Connected off New York's Tom Glavine for first career home run off a left-handed pitcher on 9/28...Hit first career home run as a pinch hitter on 10/3 at Chicago off Ryan Dempster...Batted .345 (30-for-87) with 11 doubles, five homers and 17 RBI in final 28 games, dating back to 8/26...Hit .235 (4-for-17) in five games against Houston in the N.L. Division Series...Doubled in the tying run in the 8th inning to send Game 2 to extra innings (a 4-2 Braves win)...His 6th-inning three-run homer off Chad Qualls was the game-winner in Game 4 at Houston (a 6-5 Braves win). 2003 Was named the sixth-best prospect in the Braves organization by Baseball America and as one of the Braves top prospects by Sports Weekly prior to the season...Split season between Greenville (Braves' AA) and Richmond (Braves' AAA) and batted .290 with 20 home runs and 72 RBI in 133 games with the two clubs...Began season at Double-A level and collected a hit in 12 consecutive games from 4/3-17...Hit two home runs on 5/6 at Tennessee...Was promoted to Triple-A on 6/12...Ranked fourth in the Southern League with 12 home runs at time of promotion...Recorded first Triple-A hit, a two-run home run, off Buffalo's Jeremy Guthrie on 6/13 in 6-5 Richmond victory...Selected to participate in Major League Baseball's All-Star Futures Game and went 1-for-2 in the contest...Went 4-for-4 in win over Charlotte on 7/21...Had 11-game hitting streak from 7/31 to 8/13...Homered in consecutive games on 8/22 and 8/23...Hit .337 with three homers and 12 RBI during the month of August...Was named the International League's best defensive first baseman by Baseball America. 2002 Split season between Myrtle Beach (Braves A) and Greenville...Hit .317 with 13 homers and 72 RBI in 114 combined games with the two clubs...Compiled a 16-game hitting streak while playing with Myrtle Beach from 4/13-30...Collected 11 hits in 28 at bats (.393) over six games from 5/30 to 6/5 to win the Appalachian League Player-of-the-Week Award...Reached base safely via hit or walk in 20 straight games from 5/22 thru 6/11...Went 5-for-5 with a homer and a professional-high seven RBI in 15-4 win at Frederick on 7/2...Was promoted to Greenville on 7/9...Reached base via hit or walk in 31 consecutive games from 7/20 thru 8/22, the longest such streak in the Southern League in '02...Went 4-for-4 in final game on 8/29 at Orlando...Was named the 25th-best prospect in the Braves organization by Baseball America following the season. 2001 Spent entire season with Myrtle Beach...Smacked a game-winning grand slam in bottom of 9th inning to beat Winston-Salem, 5-2, on 4/7...Hit safely in 14 straight games from 4/18 thru 5/3...Also posted an 11-game hitting streak from 7/5-17. 2000 Began professional career with Danville (Braves' Advanced Rookie) after being selected by Atlanta in the 29th round of the June draft.