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Privacy Policy
Your Privacy Rights
Last Revised: January 25, 2017
Thank you for being a valuable member of the Explore Superior online audience. You are important to us, and we respect your privacy. As used herein, "You" and "Your" refers to any individual, company, webcrawler, data aggregator or legal entity that accesses or otherwise uses the Site.
This policy ("Privacy Policy") pertains to personal information collected through this website (www.exploresuperior.com) (the "Site"), our social media, and our eNewsletters, and on Explore Superior's ("Explore Superior", "we", "us" or "our") behalf through related websites managed by us or third parties. It does not pertain to information collected in other manners or offline. California residents, please see your California Privacy Rights section below.
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It's amazing how family treasures pop up at the most unexpected times. My mother was born 17 Jan 1925 and passed away 14 July 1990. Her husband Don, my stepfather, passed away June, 1998. After attending Don's funeral, my husband Larry and I joined other family members on the front porch of his home to reminisce and share treasured memories of Don and Ruby (Flanders Margheim) Craine. My half-sister Julie came onto the porch with a small book in hand—my mother's high school diary. Until that day, I had no knowledge that this book existed.
It seems that my mother kept a diary from Monday, December, 4, 1939 until Monday, August 3, 1942. She would have been ages 14-17 during the time she was recording her day's activities in her little diary. Julie entertained us with a few selected entries from the diary. Here's a small sampling:
1. Monday, Sep 30, 1940: Went skating. Didn't have much fun Got a new pr. of oxfords. To bed at 10:30.
2. Sunday, June 8, 1941 Went to show. Judy Garland in "Little Nellie Kelly" and Humphrey Bogart in "The Wagon's Roll at Nite."
3. Friday, February 13, 1942 Went to the dance. Ray wasn't there. Got acquainted with the guitar player. (The guitar player was my dad, Ernest Margheim, whom she married in July, 1943. )
The picture above is a copy of two of the pages in her handwriting. At the bottom left is an entry that says: "Helen & I went to the dance at skating rink. We got in for 11 cents each…"
Two years ago my sister Julie sent Mom's diary to me to read and transcribe. I made copies of all the handwritten pages, enough to give a copy of the diary to my three half-sisters Jill, Julie and Jenice and my twin brother Dennis, each of her children. I started the project of transcribing each page, but only got about half way through it that summer when I had sufficient time.
I don't like to start projects and them leave them unfinished. But for the last two years much of my free time has been taken up with care that I've given to my dad as he's experienced some health challenges. Since Dad's now living independently and getting along pretty good, this year I made up my mind that I would finish the process of transcribing Mom's diary, get it printed and mailed to my siblings.
Last week I finished the transcription process and assembled the books! I felt such a sense of relief at this accomplishment.
I'm lucky to have one of my mother's photo albums from that time period and in it were photos of many of the friends she mentioned in the diary. So I made copies of many of those pictures and included them in the front of the book. It's always nice to put a face with a name!
Yesterday I sent the books to my brother and sisters. I hope they have as much fun browsing through the pages as I had reading it the first time. My mom's entries reveal many things that I found interesting:
1. she was not very interested in school at that age (but I know she was smart and made good grades)
2. she went to Sunday School
3. she helped her parents with some of their work assignments
4. she loved her siblings deeply and was excited to spend time with them
5. she had a wide circle of friends
6. she could sew, sing, play the piano, cook
7. she didn't smoke or drink alcohol and wouldn't date boys who drank
8. she shared titles of most of the movies she attended, which is historically interesting
9. and at ages 14-17 she was what I would call "boy crazy".
My mother Ruby was just a normal, healthy teenager from the very small town of Stafford, Stafford County, Kansas in the early 1940s. What a wonderful window on her life has she provided by making those daily entries into her little blue diary.

subset: commoncrawl


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Watch The ::God Is Imaginary Videos On YouTube ::
0 Members and 1 Guest are viewing this topic.
Hello,Does anyone know how I would go about deleting my account from this forum?Kind RegardsE.
I suspect you're just upset that your arguments gain no traction here.It happens quite frequently that people arrive here, highly-impressed with their own intellectual superiority and wielding arguments that are all-too-familiar and easily rebutted, as yours have been.They then flounce off, denouncing atheists in general and users of this forum in particular as stupid because we don't see the self-proclaimed brilliance of those arguments and instead reduce them to ashes.The smarter ones leave quietly to hopefully take on board what they've learned. Others engage in theatrical departures. The really poor engage in flouncing off and then return.
I always say what I mean. But sometimes I'm a sarcastic prick whose tone can't be properly communicated via text.
What is it with half the people on this site? I only asked was it possible to delete an account and you go all deep and philosophical. Answer the question if you like but keep your subjective opinions to yourself dude!
So why no responses to the people who offered what you say you wanted? Why only respond to Hickdive?Keep in mind that Hickdive posted after the helpful posts were already made. You'd already been given the answer to the question you asked. What's left but commentary?
Quote from: eddy_ydde on October 27, 2013, 08:59:19 AMWhat is it with half the people on this site? I only asked was it possible to delete an account and you go all deep and philosophical. Answer the question if you like but keep your subjective opinions to yourself dude!I thought you'd gone. Evidently simply not coming back isn't good enough and you have to someone else help you.Anyway, your question has already been answered several times by other posters. Your reaction is not to simply leave but to leave with a theatrical flourish. I doubt I could add to the previous answers and you're not smart enough to understand the ones you've been given. So why add to them?If you don't want to read the opinions of others then perhaps you shouldn't participate in internet forums, dude?
Look guys, would you snap out of it and stop jumping to conclusions. I never said anything about deleting the account that I'm currently posting from!
Does anyone know how I would go about deleting my account from this forum?
Religions need books because they don't have gods.
As Chronos said, not something we do without good cause.And as he also says - if you don't want to be here any more, just don't log in. If you find temptation too much, try this.In Notepad, type a string of random characters without looking. Double click on the string to select, then hit Ctrl and C to copy. Then go into your profile, and account settings. In the "choose" and "verify" password boxes, hit Ctrl and V to paste in that nonsense string. Type your current password at the bottom, and hit the Change Profile button.You will now have a password for the site that you cannot use, which will help you to stay away. Although password resets and reminders ARE still available, it requires a little more deliberate effort to "come back" than it does to just log in.
... as far as I was concerned it was just posted by someone who has nothing better to do but browse around the forum attacking anything that doesn't fit with their logic. ...
Well guys, if you're all so smart, try and work out what other account I own on this forum
You believe evolution and there is no evidence for that. Where is the fossil record of a half man half ape. I've only ever heard about it in reading.
I only asked was it possible to delete an account
"I'm doing science and I'm still alive."--J.C.
Hrm, why did I see this thread as bumped?Methinks a post was deleted.


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Apple Loses False Ad Claim Against Amazon
A federal judge dismissed a portion of Apple Inc.'s suit against Amazon.com Inc. over the name for its digital marketplace of applications for mobile devices.
U.S. District Judge Phyllis Hamilton granted Amazon's motion for summary judgment dismissing a false advertising claim in the case. Trademark infringement claims in the case remain to be decided.


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A little while back the kind folks at Consol gave us one of these Solar Jars to try out. We don't really write too much about products on the blog but this one is a winner. I think it has real application for South Africa where we have a load of sun and not enough electricity. It is fairly sturdily built except for the breakable glass of course 🙂 and apparently it offers up to six hours of light. Not too bad at R150. Check out more detail here.
Solar Jar
By Sprig on June 5, 2012 in sustainability
2 Responses to Solar Jar
Pi June 5, 2012 at 5:06 pm #
Great idea and on World Environment Day too
mol-d June 6, 2012 at 3:48 pm #
indeed! lest we forget! on the plus side, it looks as though there is a drive to create green jobs:
kill two birds with one stone?
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Rosemary has been a favorite ally of late, not for myself so much as for many clients and family members. It's a common ingredient in my digestive formulas, especially for those with a sluggish, overtired liver and a cold gut typified by lack of appetite, gas, constipation and bloating. I especially like it combined with Oregon Grape Root for the liver issues, and is additionally helpful in a pattern that often includes excessive, dilute urination from kidney deficiency and probably low blood pressure as well as inability to digest protein/fat efficiently. Other specific indications also include foggy thinking, general feeling of coldness, tiredness and intermittent depression with or without thyroid involvement usually with nervousness or anxiety underneath. There are also sometimes signs of heart weakness accompanying the poor circulation.
Rosmary tincture made from fresh plant in high proof alcohol is very powerful, so my proportions tend to be something like 5 parts Oregon Grape to 1 part Rosemary. If it still seems a bit too stimulating or heating for the individual but is otherwise a good match I'll adjust it to 2 parts Oregon Grape, 3 parts Burdock root and 1/2 part Rosemary. The taste is lovely and really harmonizes with the other herbs very nicely. Some amount of Lavender can also be added if there are significant signs of anxiety or insomnia, especially when accompanied by headache or confusion.
Some people don't do so well with Rosemary, often those of excess type constitution who are hot natured, prone to high blood pressure and ruddy colored. Possible signs of incompatibility include roaring in the ears, feeling like your pulse is going to bust out your head when you stand up (high blood pressure), rapid heartbeat, sharp headaches and excessive and uncomfortable flushing. If these symptoms occur either greatly reduce the dosage or cease completely. If the symptoms are unclear, withdraw it and then retest if possible. Rosemary should NOT be used where there are indications of heat, whether from excess or deficiency.
This is one of Loba's very favorite plants, I think she could live, breathe and swim in it and be very happy. We have Rosemary butter, Rosemary infused olive oil, Rosemary salve, Rosemary tea, Rosemary tincture, Rosemary lotion, Rosemary smudge, Rosemary rubbed meat and all manner of other Rosemary flavored dishes and body products. Thankfully, Rosemary is a common ornamental and culinary garden plant in NM and can be gathered in most villages and cities. This is good, because it's cold enough in the canyon that our Rosemaries tend to struggles and grow very very very slowly.
Rosemary has myriad other uses than the few I've mentioned and I'll be sure to writing about more of them in the future. Perhaps my own favorite quality of this plant is its peaceful, gentle presence and the gorgeous purple flowers that unfold from its resinous leaves. Mmm, and the warm scent that is both reassuring and alluring, delicate and full. Yum!
2 Responses to "The Warm Heart of Rosemary"
struck me looking at your picture how much rosemary seems to be brush like – clearing the way for direction to enter. it very much seems to assert a presence of being 'on its own terms', giving a really powerful forceful upward pull and supprting itself well on its own growth. the rosemary in my back yard seems touch as old boot, highly consistent and survivable!
[…] Anima Healing Arts blog entry on Rosemary […]


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Delaware Shore Field Hockey, Inc.
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Select the details below that best describe this video. We appreciate your assistance and will use this information to improve our service to you.
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next time you take my cock to fuck
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ooh yeahh
Michele fuck me
13:17 this guy sounds like Al Pacino.
that ass and those breasts are just perfect.. amazing...!!!
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I have the same dick .can v play
...and how she sucks a cock... amazing.-
lousy head... wtf you boys need to work on your cunnilingus
by far the best vid on this site, when their 69ing i busted like i gotta 25 in blackjack
Im amazed how well some of you guys type with one hand!
She sure does love being fucked...
I would like hammering her before I die
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i wanna fuck u
Video needs to be renamed to 'Michelle B has beautiful breasts, hips, ass, legs, voice, motion . . .' I could go on.
She's sucking that cock like it's a Haagen Dasz ice cream bar.
michelle, fuck me next. is that guy's cock for real? looks like a plastic club or bat. fuck. big. oh michelle you are so sweet the way you climb onto his face, straddling him in the chair for 69. Fuck me babe, come home let me lick out your pussy, take me inside you all night. I'll make you breakfast.
maria sharapova getting fucked. what a turn on. igot the biggest boner ever. look at her. looks just like maria.
wow :)
wow, nice body, nice breast, nice face and a ggod fuck 9/10, anal would have made it 10/10
Oh, to be deep in your pussy when you climax would be the pleasure of a lifetime--I hope just the first of many such pleasures. You are beautiful, sexy, desirable, and (I hope) willing for me to pleasure you.
She has beautiful pussy hole.
That looked so fucking sexy im going to fuck so hard I just wanted to do it the whole time but if you suck your a slut I'm a slut because I'm a striper so I know how to fuck I get all naked from head to toe
69ing and fucking the shit out this blonde babe would be my pleasure ! Damn she can suck and fuck ...............
who is this guy
suck his balls as he doggys her on the lounge
they are not breasts they are TITS, great looking chick
Need a milf to give my hot load with.if she can fuck like her
mera bhi chous le
A Beautiful girl sucking a beautiful cock.... mmmm good!
this man haf huge cock !!!
That is a massive cock she is sucking on. Look how it fills her mouth, the width of it. And then she fucks him. He must be filling her entirely, deeply. Oh fuck. Ohhnancy
hottest chick on this site.
Yea big time huh
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wanderfull ...
Theres one part, it is like 2 minutes long, where it really got me turned on, and I rubbed my clit to the sounds of her groaning in pleasure until I couldnt see through the intensity of my o-trip!
Spanish accent? Really?
whats her name
fuck more shit babe yeah!!!!!!!!!!!!!!!!
my favorite pornstar rite there...let me fuk u katie...i wana do u real good!!!
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you have big boobs
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fuck me
Finally, a hot British pornstar.
big play balls
big playing balls
what name of this guy
beautiful pink nipples on perfect tits.. and that's just the start!
So TT didn't cum - give him a break, sometimes you'll shag a woman to within an inch of her life but you just cum. The thing is not to get, er, "hung up" about it.
i love this woman^___^
tube that wey no imagination with tremendous mamasota woman who has and that alone
wow her breasts
Joerg Kachelmann?
Wanna cum on them
A beautiful cock, to ram a beautiful arse
One thing that spolis this for me is the stupid porno platform shoes which nobody wears in real life - only in porno movies. Not a turn-on. Barefoot or the classic stilettos they used to wear.
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hey guys, looking for men who can fuck me like this....horny girl is waiting
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He should have fuvked her butt
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michelle your pussy is hot
i have a new strategy for watching these vids: scan in to the last minute, if I see the guy jerking off to cum, i don't watch it and move onto another one. in this case, i broke my rule because she's so hot. Butafter 19:17, when the guy announces he's gonna cum and pulls out to whack off and shoot his load, the video stops. Boo to the person that posted this shit.
That's Tony Tedeschi
At last a couple who actually sound and act like they are enjoying sex rather than pretending!
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hot for a brit.
Wow shes hot :D
Che dire? super figa, super scopata e stra super pompino..... magari a me.....
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who wants 2 fuck me...........
Joerg Kachelmann?
jacques- i hear you. would love to crawl in at 1:50, slide my dick into her, being careful not to disturb the lovely blow job. i would kiss the back of her neck,and work my way around, making out with her while she sucks his cock, then eventually taking that big cock in my mouth.
So damn sexy. I would love to fuck them both at the same time.
Asif you didn't get to see him cum :( x
guao que culo
Tonight I'm going to fuck my wife like that.. i would make she make a loud of scream.. "Hooney please don't stop"
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her name????????????????????
certo che bel cazzo che ha il ragazzo!!!!
tht girl is awesome dam sexy!!!!
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can anyone tell me why so many females give awful head if at all?
this is sooooo sexy i want this girl fucking
Fuck! sUper HOT!! i wAnna SeX w/ michELLe..
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text: For possibly the first time in its history, US Vogue is attracting attention for something other than its general lack of interest. The reason; this year's 'Shape Issue' features LeBron James, the 6 ft 8 basketball player, posing with Gisele Bundchen, the 5 ft 11 supermodel. So, still questioning why this could be seen as interesting by those within the fashion world?


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We are Emmanuel College, a community with a lifelong passion for teaching and learning that believes education will create a just and better world.
We believe that education changes people. It transforms their lives. It opens doors.
We challenge our faculty and students to take a rigorous and exacting approach to learning, teaching, scholarship and research.
We believe in the enduring value of a liberal arts and sciences education. We mine the rich resources of science and health care around us. We build gateways to that world on campus.
We challenge ourselves to act. To lead. To give generously to others.
We believe that education is inclusive, that the world of ideas demands diversity.
We believe in the transformative power of real-world experience through internships, service learning, travel and opportunities abroad.
We believe that Boston offers incomparable opportunities for fun, for growth, and for serving.
We believe that education is the greatest work on earth. This belief is our rock; it is the legacy of the Sisters of Notre Dame de Namur, the backbone of our Catholic academic tradition.
To the entering, first-year student eager to gain the knowledge of the past and skills for the future and who is perhaps a little nervous, we say, we believe in you.
To the graduate, prepared for a lifetime of leadership, global engagenent and profound purpose, we say, we believe in you.
We are a community of believers. A community with a strong sense of mission, a vibrant and confident faith and a joyful spirit.
We are Emmanuel College. We believe. We challenge. We transform.


text:
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rustymason wrote:On a related note, I have finished entering almost all of the D'Ooge vocabulary, grammar, and lesson questions and answers into the BYKI format
Marty mus wrote:It is now available on Amazon.
metrodorus wrote:The 1911 text is, I notice, also available as a reprint from Public Domain reprints, for $12.96
metrodorus wrote:Over the last couple of months, following from a few requests both from textkitters and others who like this book, I have been recording Dooge's text in audio, for release as a DVD - I expect it to be online in a few days from now.
My version refers to the pagination of the original edition, and has 107 episodes.
I have also just finished recording Underwood's Latin Course for medical students - all the verb and noun paradigms, and all the examples, are tailored to the medical and pharmacology student. It makes for an interesting twist on the standard approach.
nov.ialiste wrote:I just ordered a copy of this book from bookdepository.co.uk for €12.14 (and free postage to anywhere in the world).
A couple of years ago I worked through about two thirds of the book from the internet. It'll be nice to have a printed copy and in due course I hope to complete my study of the book (I'm studying Oergberg's Lingua Latina 1 at the moment).
ivanus wrote:I'm curious if you will make an e-book edition available. While I like the printed editions, I don't like the weight, so e-books are better for transient study. Having a native PDF where you get crisp text and can change the font size is a real improvement over image scans


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Deleting Unversioned SVN Files
Here's a silly bash trick that will delete all unversioned SVN files
svn st | grep "^?" | sed s/?[[:space:]]*// | xargs rm -rf
Use with care, obviously. If there's a more concise method, please let me know.
And here's how you might use similar commands to apply
fmresolve to all conflicted files, and then resolve them.
for f in $(svn st | grep "^C" | sed s/C[[:space:]]*//); do fmresolve $f; done svn st | grep "^C" | sed s/C[[:space:]]*// | xargs svn resolved


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Radeon™ Software Crimson ReLive Edition is AMD's advanced graphics software for enabling high-performance gaming and engaging VR experiences. Create, capture, and share your remarkable moments. Effortlessly boost performance and efficiency. Experience Radeon Software with industry-leading user satisfaction, rigorously-tested stability, comprehensive certification, and more.
Radeon Software Crimson ReLive Edition 17.10.3 Highlights
Fixed Issues
Wolfenstein™ II: The New Colossus may experience a crash or application hang on game launch with Radeon RX Vega series graphics products.
Known Issues
Package Contents
The Radeon Software Crimson ReLive Edition 17.10.3 installation package contains the following:
The Radeon Software Crimson ReLive Edition 17.10.3 installation package can be downloaded from the following links:
By clicking the Download button, you are confirming that you have read and agreed to be bound by the terms and conditions of the End User License Agreement ("EULA"). If you do not agree to the terms and conditions of these licenses, you do not have a license to any of the AMD software provided by this download.
Installing Radeon Software Crimson ReLive Edition 17.10.3 For detailed instructions on how to correctly uninstall or install Radeon Software Crimson ReLive Edition, please refer to the following support resources:
NOTE: This driver is not intended for use on AMD Radeon products running in Apple Boot Camp platforms. Users of these platforms should contact their system manufacturer for driver support.
When installing Radeon Software Crimson ReLive Edition 17.10.3 for the Windows® operating system, the user must be logged on as Administrator, or have Administrator rights to complete the installation of Radeon Software Crimson ReLive Edition 17.10.3.
Radeon Software Crimson ReLive Edition 17.10.3 requires Windows 7 Service Pack 1 to be installed.
Radeon Product Compatibility Radeon Software Crimson ReLive Edition 17.10.3 is compatible with the following AMD Radeon products.
Note: AMD Radeon™ R9 Fury, Radeon™ Pro Duo, Radeon™ RX 400 & RX 500 Series are only supported by Radeon Software Crimson ReLive Edition on Windows 7/10 64-bit.
Mobility Radeon™ Family Compatibility Radeon Software Crimson ReLive Edition 17.10.3 is a notebook reference graphics driver with limited support for system vendor specific features.
Compatible Operating Systems Radeon Software Crimson ReLive Edition 17.10.3 is designed to support the following Microsoft® Windows® platforms. Operating System support may vary depending on your specific AMD Radeon product.
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1. Re: Q77 (DQ77MK) currently unusable for AMT/vPro
Ouch..... somebody at Intel has messed up ...... maybe they will correct these issues with a BIOS+ME upgrade
I'm glad I'm still on Q67EP motherboards.
2. Re: Q77 (DQ77MK) currently unusable for AMT/vProRadu Bogdan May 15, 2012 10:28 AM (in response to Raven737)1 of 1 people found this helpful
The Q77chip has not been officially launched. Probably that is why they are still delaying the launching because of this issues that you've discovered. I'm sure they'll fix this issue with a future BIOS+ME upgrade.
Thank you for your findings+ trouble to put everything together.
3. Re: Q77 (DQ77MK) currently unusable for AMT/vPro
Thanks for your feedback. Pre-production boards can be a frustrating experience at times, as they are pre-release, so we always encourage users to work with the Intel representative who provided the sample. But with that said, we officially launched the 3rd Gen Intel Core vPro Processor Family yesterday! Q77 is now officially released – you can find details about Q77 and other vPro-compatible chipsets at http://ark.intel.com.
4. Re: Q77 (DQ77MK) currently unusable for AMT/vPro
If Q77 is officially released why do you still have this info for the Q77 motherboards as a pre-production card ?!?!?
Ex: http://www.intel.com/p/en_US/support/category/dsktpboards/db-dq77mqmk/doc_guide
5. Re: Q77 (DQ77MK) currently unusable for AMT/vPro
1 of 1 people found this helpful
6. Re: Q77 (DQ77MK) currently unusable for AMT/vPro
Too late: Page Not Found.
...and I can't found any information about Q77 at ark.intel.com
7. Re: Q77 (DQ77MK) currently unusable for AMT/vProRaven737 May 20, 2012 3:07 AM (in response to Uglyroid )
Yes, although the Chipset was officially launched, there is no Info. on it or any Intel Mainboard using it on ark.intel.com but at least the drivers are already shown in the Download Center
Also, I bought the board from regular retailer. It was factory sealed (for example the Anti Static Sticker on the Anti Static bag etc) and not labeled or sold as Pre-Production. Since the "official release" was just a few days later I expect that the board was shipped to retailer in preparation for the launch and they decided to ship it out as soon as they received it and so I received it a few days before the launch day.
In any case, i found out that if i power down the system, turn off the PSU for 30 seconds, then turn it on again and power on the system via the Power Button (not via AMT) then the link speed stays at 1Gbps. So it seems that it only gets stuck when it is accessed in a power down state.
Now I'm having trouble getting a RAID controller to work ( DQ77MK problem with RAID Controllers? ) and I get critical temperature warnings when i use Quick Sync ( VR overheating with QuickSync? )
Either i have no luck with this board or it really was not quite finished yet But as @Radu said, I'm hoping a BIOS+ME Upgrade will fix these issues.
8. Re: Q77 (DQ77MK) currently unusable for AMT/vProjake_friz May 22, 2012 1:59 PM (in response to Raven737)
#1 - I have the same board and the way into MEBx is CTRL-p. Of course, my board is preproduction. As far as I know, the final version will have an AMT section in the BIOS itself. A BIOS update should correct this but I can't comment on if/when it's available.
#2 - I don't know why this is happening, but I will ask the SCS team to take a look. In the mean time, the AMT SDK has a tool called USBFile.exe. You might try that as a work around.
#3 - IDEr is slow for a number of reasons. It is great for booting small recovery images, but not so good for a full OS install from raw a DVD image. However, there are methods for using IDEr to install an OS that are much faster. In a nutshell, make a share and copy all Win7 install files to it. Then, build a WInPE image. User IDEr to boot WinPE, map the share, and run install from there. It will go MUCH faster. You can speed it even more using 2 stage boot to start WinPE. And the whole thing can be automated with an unattend.xml file and/or some batch files. You also mayt check out "Easy Reimage" from here.
#4 - the timeout is adjustable. How to do this depends on the remote tool you are using. For example, RealVNCViewer Plus has an advanced / expert tab. There you can set the "AMTSessionTimeout", which is in minutes. 0 means never timout.
#5 & 6 - Once a static session, that is SOL, KVM, or IDEr is open to AMT, the link speed will not change until the session closes and the link is re-negotiated. If it did, the session would drop. Further, when the OS LAN driver is not up, AMT negotiates 10 Mbps to save power. So, yes, there are times when the link speed will get stuck at 10 Mbps. However, it should "unstick" once the AMT session closes and the LAN driver re-links. I'm not sure why you need to power off. You should be able to just stop SOL, KVM, and/or IDEr, and then pull the LAN cable or stop and start the LAN driver or just reboot. Just be sure the AMT session is not still open. Also, note, that if the OS driver is up and has negotiated a faster speed and then you start the AMT session, the faster speed will stay in place. A final note, WS-Man communication to AMT (E.G. getting an inventory list, checking the WebUI, doing a remote reboot) will not cause this.
9. Re: Q77 (DQ77MK) currently unusable for AMT/vProRaven737 May 23, 2012 11:49 AM (in response to jake_friz)
Hello Jake,
thank you for your answers!
1: When i press CTRL+P during boot, nothing happens. I tried it without KVM, directly connected via a regular keyboard and monitor and via KVM. I do not see a prompt to press CTRL+P either. See: http://www.youtube.com/watch?v=5IJDn7xpk7I&hq=1
3: Ok, I understand and will try to only boot a minimal system and initiate the install from there to pull the needed files via lan instead of the redirected IDE DVD.
4: For me the setting was set to -1 instead of 0. Apparently this means a default timeout is used (I assumed -1 meant it was disabled). Setting it to 0 did indeed fix the timeout problem. Thank you!
5&6: I understand that as long as a session is open the link is stuck at the current link speed. As far as I understand from your answer, pulling the LAN cable would initiate a reset. I tried this and it did not work, see: http://www.youtube.com/watch?v=ENMqrMS9uIw&hq=1
A reboot without any AMT session however did reset the link speed to the full 1Gbps. I suppose before I did still have a session open and that is why it did not work. Thank you!
I have other problems with the boot process too, such as being unable to setup the build in RAID. I would expect a prompt (CTRL+I/R) after i enabled the SATA->RAID modus, however, i see no such thing. Maybe this is related to also not seeing the CTRL+P prompt (or is there no prompt?).
It was suggested that my board may be a "pre-production" board. How can i find out if it is or not? Are there any markings/special serial number or such?
Thank you!
10. Re: Q77 (DQ77MK) currently unusable for AMT/vPro
Can someone at Intel please provide an update on this? We need to pull the trigger on a large DQ77MK order with Tech Data (production? boards in stock), but need full vPro functionality. We cannot afford a rework on this, or even a BIOS flash, as the systems will be all over the country - and that's hard to do without vPro ...
11. Re: Q77 (DQ77MK) currently unusable for AMT/vPro
It would appear this board is no longer listed as a pre production board, is this board ready for prime time yet? I would like to purchase current generation SKU's, but if these boards are still in Alpha state I will go with something else.
12. Re: Q77 (DQ77MK) currently unusable for AMT/vProRadu Bogdan Jun 6, 2012 10:52 AM (in response to Jerrad )
I checked myselft as well and you are right. Intel has removed the pre-production "logo" from the Q77 boards. That means they are ready for prime time support .
These Q boards get updates constantly, probably they are working on the issues described above right now for the next release of the ME + BIOS.
13. Re: Q77 (DQ77MK) currently unusable for AMT/vProRaven737 Jun 7, 2012 8:56 AM (in response to Radu Bogdan)
I do not see a "pre-production" logo on my board although I do not know what it is supposed to look like, I would assume that I would recognize it when if I saw it (something simple as "PRE-PRODUCTION" being clearly marked or such).
At this time, the Board is still not listed with the other executive series mainboards in:
However, googling shows the following pages: Overview and Support.
The latest "Intel® ME: Management Engine Driver for Intel 6 & 7 Series Chipset-Based Desktop Boards" do not work as well as the ones that were included on the CD as now the Console no longer shows the status of any AMT component, only 'unknown'.
Still waiting for the Bios/Firmware update that will fix everything.
14. Re: Q77 (DQ77MK) currently unusable for AMT/vPro
Just to stay in a weekly update cycle.
No ME / vPro available. Even the "ME" menu in bios is not available. I also do not see any kind of "pre-production" or something similar. Neither on the box nor on the board itself, even not in bios.
It surprises me that Intel cannot provide a fix to this functionality, because it is one of the major reasons for the Q-chipset. I thought Intel would be a premium manufacturer, but maybe I would have done it better with some "cheap & dirty" manufacturer, where things simply work and if not updates are provided.


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Drumma Boy Talks Young Buck Mixtape, New Gucci Mane/Master P Collabo, Jeezy LP & More
The Project: Young Buck's new mixtape, Back on My Buck Shit 2: Change of Plans
Drumma Says: "The fuel for this mixtape came from the VH1 Hip-Hop Honors this year that honored the South. The whole state of Tennessee was excited about that shit. VH1 was honoring the South and I just knew they were gonna call me. [Laughs] And then they didn't say shit about Tennessee! No 8Ball & MJG. No Three 6 Mafia. We got Oscars, man! And we don't get a mention? We didn't appreciate that. So this mixtape was our campaign. Me and Buck had already been talking about doing work together and then that just gave us a reason to do a whole project together. Since they want to look over us, we got something for them."


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CORK CITY, Ireland, July 11 (UPI) -- BINGO!
A middle-aged Irish woman was arrested this week after allegedly dealing cocaine at a bingo hall.
Helen Heaphy appeared in court and was charged with possession of cocaine and having the illegal drug for sale or supply because of her alleged actions.
The suspect declined to respond to either charge during her court appearance.
The 50-year-old woman was banned from attending Rock Bingo events at the Deanrock Business and Technology Park until the matter is resolved.
Heaphy is due back in court in September.


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Polysomnography, also called a sleep study, is a test used to diagnose sleep disorders. Polysomnography records your brain waves, the oxygen level in your blood, heart rate and breathing, as well as eye and leg movements during the study.
Polysomnography usually is done at a sleep disorders unit within a hospital or at a sleep center. You'll be asked to come to the sleep center in the evening for polysomnography so that the test can record your nighttime sleep patterns. Polysomnography is occasionally done during the day to accommodate shift workers who habitually sleep during the day.
In addition to helping diagnose sleep disorders, polysomnography may be used to help adjust your treatment plan if you've already been diagnosed with a sleep disorder.
Polysomnography monitors your sleep stages and cycles to identify if or when your sleep patterns are disrupted and why.
The normal process of falling asleep begins with a sleep stage called non-rapid eye movement (NREM) sleep. During this stage, your brain waves, as recorded by electroencephalography (EEG), slow down considerably.
Your eyes don't move back and forth rapidly during NREM, in contrast to later stages of sleep. After an hour or two of NREM sleep, your brain activity picks up again, and rapid eye movement (REM) sleep begins. Most dreaming occurs during REM sleep.
You normally go through four to six sleep cycles a night, cycling between NREM and REM sleep in about 90 minutes. Your REM stage usually lengthens with each cycle as the night progresses. Sleep disorders can disturb this sleep process.
Polysomnography monitors your sleep stages and cycles to identify if or when your sleep patterns are disrupted.
Your doctor may recommend polysomnography if he or she suspects you have:
Polysomnography is a noninvasive, painless test. Complications are rare. The most common side effect is skin irritation caused by the adhesive used to attach test sensors to your skin. Napping the afternoon before the sleep study is usually discouraged.
Your doctor may ask you not to drink alcohol or eat or drink anything with caffeine during the afternoon and evening before polysomnography. Alcohol and caffeine can change your sleep patterns, and they may make symptoms of some sleep disorders worse.
You arrive at the sleep center in the evening for polysomnography and stay overnight. You may bring items you use for your bedtime routine, and you can sleep in your own nightclothes.
The room where polysomnography is done is similar to a hotel room, and it's dark and quiet during the test. You don't share the room with anyone else. The room has its own bathroom.
The room has a video camera, so the polysomnography technologists monitoring you can see what's happening in the room when the lights are out. It also has an audio system, so they can talk to you and hear you from their monitoring area outside the room.
After you get ready for bed, one of the technologists places sensors on your scalp, temples, chest and legs using a mild adhesive, such as glue or tape. The sensors are connected by wires to a computer, but the wires are long enough to let you move normally in bed. A small clip also is placed on your finger or ear to monitor the level of oxygen in your blood.
While you sleep, a technologist monitors your:
All of these measurements are recorded on a continuous graph.
Polysomnography technologists monitor you throughout the night. If you need assistance, you can talk to them through the monitoring equipment. They can come into the room to detach the wires if you need to get up during the night.
During the study, the technologist may have you try a positive airway pressure (PAP) machine for sleep apnea. This is a device that consists of a tight-sealing nosepiece through which a gentle stream of air is delivered to enhance your breathing.
You will have the opportunity to try on a PAP device before the sleep study begins so that you are not surprised by it if tried later in the night. If necessary, oxygen also may be used during the study to bolster your breathing.
Although you probably won't fall asleep as easily or sleep as well at the sleep center as you do at home, this usually doesn't affect the test results. A full night's sleep isn't required to obtain accurate polysomnography results.
In the morning, the sensors are removed, and you may leave the sleep center. You're given an appointment for a follow-up visit with the doctor who recommended the test. You can return to your usual activities after polysomnography.
The measurements recorded during polysomnography provide a great deal of information about your sleep patterns. For example:
The information gathered during polysomnography is evaluated first by a polysomnography technologist, who uses the data to chart your sleep stages and cycles. Then that information is reviewed by your sleep center doctor.
It may take up to two weeks to receive the results of polysomnography. At a follow-up appointment, your doctor reviews the results with you. Based on the data gathered, your doctor will discuss any treatment or further evaluation that you may need.
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Wyatt Smith's stint with the Bruins organization got off to a slow start because of an injury at the outset of training camp and never got on track.
So, according to a report at ProJo.com, the veteran center is leaving the Providence Bruins to skate in the German Elite League.
Smith,33, was signed in late summer to a one-year, two-way deal to make up for the loss to injury of last year's Providence captain Trent Whitfield. Smith was waived and then assigned to Providence before Boston left for its season-opening European road trip.
But things didn't work out with the P-Bruins, as he posted a team-worst minus-14 rating in 30 games.
This afternoon, TSN.ca reported Smith cleared waivers which was the last hurdle before he could cross the pond and play in Germany.


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- Details
- Created on 25 August 2009
- Last Updated on 23 June 2013
- Written by Nero666
- Hits: 7773
The Thrakian Bessoi are a tribe with the reputation of being wild and savage even among the wild and savage Thrakian tribes that inhabit the region north of Hellas. Sharing only minimal cultural ties with their southern brethren the Thrakians are rightly feared for their ferocity and impetuous nature. Occasionally raiding into parts of Makedonia and fending off raids from the Skudata are the most organized of the Bessoi international politics. But usually the Thrakian tribes fight each other more than any unified enemy. But with a strong chieftain able to manipulate the will of these terrifying warriors, the Bessoi could bond the tribes into a most fearsome fighting machine.
Their lands are brutal and unforgiving to the Greeks in the south. But the Bessoi battle the elements for survival and it has made them a hardy people. The lack of resources in the area forces the Thrakians to raid Northern Greece for booty and slaves. This forced conflict will soon brew into bloody wars with first Makedon and maybe further into the more powerful city states of Greece. The Thrakian war machine consists of fierce warriors willing to sacrifice their lives for pure blood lust. With most nimble but deadly men the Thrakians formed the archetype of the Peltast while the nobles support all their actions. A perfect combination for the thick Thrakian woods.
With the Skudata constantly raiding their provinces the Bessoi will need to find new resources quickly to build up armies to halt their advances. When the Bessoi have secured their kingdom and found their target, the rest of the world will learn to tremble at the news that the Thrakians are coming for their homes!


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Word that Madonna will direct "W.E.," a biopic about Edward VIII and Wallace Simpson, can cause ensure that any optimism gets, well, swept away.
But then an actress like Vera Farmiga signs on as Wallace Simpson and that optimism slowly returns. Standing at the podium of the Oscars nominees luncheon yesterday, Farmiga excitedly discussed signing onto the project.
"To me it's an epic love story," she said. "A woman who fell in love with a man who happened to be the King of England."
And one who happened to give up the throne because of the fallout from the relationship.
"To give that up for love and to see how that love was affected by the pressures put on them," said Farmiga "I'm fascinated with her."
Looking at Farmiga's face it's clear that she has the bone structure to be an effective Simpson look-alike. And you could argue that the role will be an extension of her "Up in the Air" character, to which she brought class and warmth when there could have been caricature.
Farmiga said it was a matter of finding financing for the film."There are very few films between $5 million and $500 million that are being green-lit," she said. "It's just fingers-crossed."
Somehow with Madonna, you have to believe this funding will come.


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It's the same old story…I have an idea, I toy around with a scene here a plot sequence there. But until I grab the stack of post-it notes and start plotting, I have nothing. I can picture the beginning and the end, but the journey in the middle is hazey.
I've committed to make 2013 the greatest novel output of my writing career and so, in this 2nd month, I've implemented three things:
1. Scrivener A program for writers that has a corkboard, index cards, endless supply of paper and an outlining process that makes sense. Despite past bad reviews, the folks at Literature and Latte dot com have fussed and fixed the program. I love it!
2. Story Elements by Larry Brooks. This book, while quite wordy initially, has been invaluable to me this month. It set out on a platter the key pieces of a story, what they look like and where they belong. Blueprints to a best seller! With the Scrivener program and this book, I've plotted out an entire novel. Now I just have to finish writing it.
3. I unplugged when it's writing time. In clicking the button "disconnect from wireless" I have connected my brain to my goals. The world wide web is a perfect distraction from everything we want to acheive. Sure, I will use it to market, to meet other writers and parents, but when it's time to write, I will write scenes for my latest novel, not facebook updates. Clicking "Like" will not get with work done!


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Courtesy of Tattoo Archive: Another one of Thomas Edison's stencil pens showed up for sale on Ebay recently. This device is often described as "the first electric motor driven appliance produced and sold in the US." This is not easy to prove, but sure sounds good! Of course to the tattoo world this stencil pen is the grandfather of all electric tattooing machines. The one on Ebay was listed as "Buy it Now" for $35,000. The last time I checked there were no takers, but it got me to thinking more about the machine's inventor and builders. Edison held at least four different US patents for his stencil pen ideas. The first was issued on August 8, 1876; this was an abbreviated version of the patent he had received one year earlier in England. Edison took some of the other ideas from the English patent, and in 1877 and 1878 got US patents for them…
The most popular of these machines is the 1876 version and to our knowledge, machines from the other three patents have never been seen. For many years the tattoo world thought there was only a couple of these 1876 machines in the world, but thanks to the marvel of the Internet and Bill Burns, we now have the electric pen registry (http://electricpen.org). That's right! According to Burns' research there are at least 28 of Edison's stencil pens known to exist. Many can be found in national museums and private collections, but we know of at least three in private tattoo collections.
Thomas Edison had enough genius to know that he need educated, hard-working, dedicated people to be his hands in the laboratory. Unlike many inventors, Edison depended on these "muckers," as Edison like to call them, to do the somewhat tedious work of building and testing his many inventions. Remember Edison had over 1,000 patents to his name. Edison was the idea man! These muckers came from all over the United States and Europe to work with him. Some were just out of training schools or college but what they had in common were that they were all chasing their dreams. The pay was not great but the opportunities were many and most of these people spoke highly of Edison even after they left his employment. Many of them were patents holders themselves and were able to work their way up the ladder to executive positions in one Edison's many businesses at home and abroad.
Often called Edison's right hand-man, Charles Batchelor (1845-1910) was involved in many of Edison's projects, including the electric pen. Batchelor was born in England and first came to the United States working for the Coates Thread Company. He met Edison and soon became one of his most trusted partners. In Batchelor's personal technical notes & drawings it is obvious that Batchelor had a lot of input in the design of the electric pen. Batchelor worked his way up the Edison ladder and became an investor and manager of several of Edison electrical companies. An interesting side to this story is a note in the Edison Papers that Charles Batchelor wrote to his brother Tom (no last name given) in Manchester, England where he told Tom all about the electric pen and it workings. For years a story has circulated in the tattoo world that Tom Riley, a well-known English tattooist, patented a tattoo machine in the late 1800s. Tattooist George Burchett even talked about the Riley machine in his memoirs.
This Riley patent has never been found. Could Tom Riley be Charles Batchelor's brother? Could Riley have been bragging about his brother's work and that's how the story of Riley's patent got started? We might never know! John Ott (1850-1931) seems to be the mucker most involved with the hands-on building of Edison's stencil pen. John and his younger brother Fred were machinists who went to work for Edison in Newark, New Jersey in the 1870s. John Ott became Edison's principal model and instrument maker after the move to Menlo Park, New Jersey in 1876. He was also the superintendent of the machine shop in West Orange in 1887. Bill Burns's research led him to believe that John Ott was instructed by Batchelor to make the first of the electric pens on September 6th, 1875.
The first batch was made by hand with Ott doing the tooling of this first production run. At this time Ott was working in Edison's Newark shop. The stencil pen included a duplicating press and ink roller which was made by Gilliland & Co. in Menlo Park. Once regular production began, Gilliland took over all the manufacturing and operated as the Electrical Pen & Duplicating Press Co. In November 1876, Western Electric took over production of the pens from Gilliland. In 1895, John Ott suffered a terrible fall and was severely injured. He spent the rest of his life using crutches and a wheelchair. Ott died on October 19, 1931, the day after Thomas Edison's death. The story goes that at Mrs. Edison's request, Ott's wheelchair and crutches were placed by Thomas Edison's casket.
Tattoo Archive © 2010
- Thomas Edison's workshop, late 1800s.
- Thomas Alva Edison (1847-1931).
- Drawing from Edison's 1876 patent. This is the one that started it all.
- Drawing from Edison's 1877 patent. A design idea that Charlie Wagner took for his 1904 patent.
- Drawing from Edison's second 1878 patent — an air or water driven version.
- Drawing from Edison's 1878 patent — a gear driven version.
- Pencil drawing for the 1877 stencil pen idea from Thomas Edison's letters.
- This is the crown jewel of Edison's stencil pen idea — the 1876 machine.
This installment of For the Record is featured in Tattoo Artist Magazine issue #21. [divider]
More "FOR THE RECORD" Tattoo History Blogs: – Tatts Thomas – Stencils – History of Tattooing in Chicago – Pelikan Ink – Saint George & the Dragon – Thomas Edison and Tattooing – Doc Webb – The PIKE – Tattoo Pigments – The Zeis Studio Flash – Coney Island and Tattoos – Percy Waters Machine – Tattoo Stamps – The Rose Tattoo – Jack Redcloud – Bill the Beachcomber – Sailor Jack Cripe – [divider]
*To see MORE and learn about some of the MOST AMAZING tattoo artists of our age, check out these deals from Tattoo Artist Magazine! There's a reason tattooers themselves consider TAM the most informative and important tattoo magazine ever —
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The Louisiana Natural Heritage Program (LNHP) within the Louisiana Department of Wildlife and Fisheries (LDWF) is cooperating with several partners to move coastal prairie plants threatened by road construction to existing prairie restoration sites.
Southwest Louisiana once contained vast expanses of coastal prairie interspersed with gallery forests adjacent to streams and bayous. These coastal prairies, similar to tallgrass prairies of the midwestern U.S., were incredibly diverse with more than 500 plant species and serving as home to a multitude of grassland birds, waterfowl, insects and other wildlife.
The estimated 2.5 million acres of original Louisiana coastal prairie have been reduced to less than 1,000 acres. Much of the former prairie was converted to pasture for cattle grazing, or altered for growing rice, sugarcane and forage crops. The majority of the remnant prairies now exist along railroad rights-of-way between railroad tracks and highways, and are continually threatened by human activities.
One of these highway segments, U.S. Highway 165 between Kinder and Interstate 10 in Allen and Jefferson Davis parishes, is currently slated for a road-widening project. The majority of the prairie remnants along this stretch of U.S. 165 are located to the east of the roadway, while the road expansion will occur to the west side. However, one small four-acre prairie remnant identified by LNHP is in the path of the proposed roadway.
LDWF is working with the Louisiana Department of Transportation and Development, the landowner of the prairie site (Gulf South Pipeline Corp), and other organizations to rescue the prairie plants found on the area. Working together, these groups plan to dig the prairie sod by hand from the U.S. 165 project site and transport and transplant the sod to two existing prairie restoration sites, one in Eunice and the other near Duralde.
This is a multi-group effort, with volunteers and technical assistance also coming from the Cajun Prairie Habitat Preservation Society, the Natural Resources Conservation Service, the U.S. Geological Survey National Wetlands Research Center, the U.S. Fish & Wildlife Service, Allen Parish Correctional facility, AmeriCorps of the University of Louisiana at Lafayette, The Nature Conservancy, and others.
LDWF, in preparation for implementation of its new Comprehensive Wildlife Conservation Strategy, views this as an opportunity to help preserve part of the imperiled coastal prairie habitat, while developing relationships with the many partners on this project.
EDITORS: For more information, contact Patti Faulkner, Natural Heritage Program ecologist, at 225-765-2975 or firstname.lastname@example.com [3].


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Think of "The Blob" in that bad old movie — a giant amoeba-like alien that globs onto and absorbs humans. Endocytosis, the life-sustaining process by which cells absorb large proteins and other molecules, is something like that, and it's an amazing ability. A squishy, water-resistant wall that isolates and protects the cell's innards, the cell membrane can also pucker into a mouth-like opening that engulfs external molecules and closes off into a spherical chamber called a "vesicle" that's absorbed into the cell.
Similar abilities of the cell wall to form a vesicle are involved in transporting molecules out of the cell, such as neurotransmitters bursting out of nerve cells. Other processes, such as those that generate tubules in muscle cells, also involve curving of the cell wall. All these processes have many steps, but they all start with "remodeling" — a change in membrane curvature.
"Membrane remodeling is one of the most important phenomena in cellular biology," says University of Utah chemist Gregory Voth. "It's fundamental to vesicle budding, a key feature of many processes, one of the most well known being neurotransmitter release in the synapses."
Experiments show that these complex events are triggered by an ensemble of proteins, and they show also that a banana-shaped protein segment called the BAR domain is a key player in inducing the cellular membrane to curve. But how? The experiments show that the BAR domain is involved, but they don't show the structural and dynamic bottom-line, what individual atoms are doing as curvature proceeds, which is where Voth and Phil Blood — then a University of Utah Ph.D. candidate, now a PSC scientist — came into the picture. "What we've been able to do via molecular dynamics simulations," says Blood, "is to see the atom-by-atom details of how these proteins generate membrane curvature."
Using PSC's Cray XT3 as their workhorse, along with TeraGrid systems at SDSC, NCSA and the University of Chicago/Argonne, Voth and Blood did molecular dynamics (MD) simulations that track the atom-level interactions between a BAR domain and a model of cellular membrane. Their simulations — involving 738,000 atoms, using more than two-million XT3 processor hours — are among the largest biological computations ever performed.
Their results, reported in Proceedings of the National Academy of Sciences (October 10, 2006), confirm and go beyond experimental results, showing that BAR domains act as a scaffold, forcing the membrane to adopt their curvature, and that the orientation of the BAR domain as it attaches to the membrane determines the degree of curvature.
Extending this success from 2006, Voth and Blood this year refined their simulations to look more deeply and see more exactly which parts of the BAR domain structure drive curvature. They found — contrary to what had been surmised from experiments — that helical structures at each end of the BAR domain do not by themselves initiate curvature.
"With this kind of work," says Voth, "we're beginning to see how the modern capabilities of molecular dynamics simulation touch very fundamentally important biological processes. There's been this investment both in hardware and software. This combination is paying off. With this kind of problem, we're getting at the interplay between proteins and membranes at a level beyond binding studies and ion-channel transport, and we're able to see whole-scale changes in the membrane morphology driven by these interactions."
In 2004 a team of British scientists laid the groundwork for Voth and Blood's simulations by working out the three-dimensional structure of the BAR domain, work that appeared on the cover of Science. "They solved the crystal structure for this protein," says Blood, "and it was quite interesting to see that it looks like a banana, a crescent shape that immediately says to you, 'I'm a curvature forming protein.'"
Bending the Membrane
This front view from a simulation on PSC's Cray XT3 represents a BAR domain protein segment (pink & yellow helices) bending a segment of cellular membrane with negatively-charged lipid head groups (green) after 30 nanoseconds of simulation. Loops on each end of the BAR domain bind tightly to the descending sides of the curved membrane. The N-terminal helix (yellow) is embedded in the bilayer. The side view shows a cutaway of the embedded N-terminal helix and also shows the loop structure that binds to the membrane surface.
Beginning with its shape, the BAR domain suggested a number of possibilities for how it could generate curvature. The concave side of the crescent carries a positive electronic charge, which could bind to the negatively-charged surface of a cellular membrane and mold it to a matching curvature.
BAR domains also have a helix structure at each end, and experiments suggest that these "N-terminal helices" insert into the membrane, anchoring the protein at its base on both ends, which could help to induce puckering of the membrane. "There are many nuances," says Blood, "but nothing had been shown explicitly."
As Blood began to build a computational model, using the DataStar at SDSC and IA64 at NCSA along with a system at Argonne, he knew he'd taken on a demanding task. "The TeraGrid has been essential to making this possible." With MD software called NAMD (Not just Any Molecular Dynamics program), developed by Klaus Schulten's group at the University of Illinois, Urbana-Champaign, along with the XT3, Blood was working with the most powerful tools available for MD simulations at the large scale his problem demanded.
"NAMD has been amazing," he says, "because it scales well even with the long-range electrostatics." The problem required accurate treatment of the electronic charges between atoms, and the MD software tracks these forces as they vary between every atom in the simulation at each time step as the simulation progresses.
Scaling, a crucial feature for a large problem such as this, means that as you recruit a large number of processors for the computation — Blood used 512 XT3 processors — the per-processor performance remains high, doesn't take a prohibitive hit due to the inter-processor communication involved in tracking the atom-to-atom dynamics.
Among MD programs, NAMD is exceptional in its ability to run efficiently with hundreds or thousands of processors, and this is especially true on the 4,000-processor XT3, which has outstanding inter-processor bandwidth. "With the XT3, we haven't found a hard upper limit on scaling," says Blood. "Our simulations have run well with 512 processors, and we've used up to 1,024 processors on this system with little dropoff."
As Blood built his computational model and explored the size of the problem, he began with a patch of membrane — 342,000 atoms, 25 nanometers in length — that was in itself a demanding computation. Trial studies showed, however, that this wasn't enough length for curvature to become apparent. Not long after the XT3 became available as a production system in October 2004, Blood doubled the size of his membrane model to 738,000 atoms — a 50-nanometer length of membrane, the longest patch of membrane ever simulated. "The XT3," says Blood, "came online just at the time when we needed it to make this work."
He ran two very large-scale simulations with this membrane and the BAR domain, tracking 27 nanoseconds (billionths of a second) of the dynamics, at time steps of two femtoseconds (millionths of a nanosecond). The two simulations resulted in two different orientations of the BAR domain, with the membrane curving to match the protein in each case. A control simulation with the membrane alone, no protein — on the DataStar system at SDSC — produced no similar curvature.
These results showed convincingly that the BAR domain generates membrane curvature and that the degree of curvature depends on the BAR domain's orientation. For Blood, they also raised a question. "How much of that curvature is due to the N-terminal helices and how much is due to the charged concave surface?"
Some experiments suggested that the helices were the main driving force, with the concave surface providing little more than a scaffold. Another series of simulations, mainly on the XT3, showed that — at least for an individual BAR domain — this is not the case. These simulations showed, furthermore, that a particular structural element of the BAR domain, positively charged loops near the end, are crucial, binding to and stabilizing the BAR domain on the membrane surface, and without the binding of these loops curvature doesn't occur. "From these studies," says Blood, "it looks like the N-terminal helices are not primarily responsible for driving curvature."
In a follow-on study (Biophysical Journal, May 2007) Voth, Blood and their colleague Gary Ayton used the MD results as input to a larger-scale model of membrane shape change. "We use the molecular dynamics to feed a model at the meso-scale," says Voth, "and show how the interactions generated at the atomistic level propagate and scale up to a larger scale of remodeling."
Based on their success with NAMD and the XT3, Voth and Blood are looking ahead to even bigger, more realistic simulations. "The next generation of these simulations," says Voth, "will push up to 10-million atoms, which we'll need to look at multiple interacting BAR domain proteins and to develop accurate but simpler coarse-grained models for these systems. In nature, it's the collective behavior of many of these proteins interacting with the membrane that creates curvature. There isn't a good experimental way to look at this. This is the frontier in this field. These simulations are indispensable."


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10. Competition commences 29/04/15 and ends at 11.59pm (AEDT) on 10/05/2015. All claims for prizes must be received by 18/05/2015 ("Competition Period").
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If you have ever driven a car with a GPS system (installed or portable), then you are probably one of Garmin's many unsuspecting customers. Garmin is the largest manufacturer of personal navigation devices in North America, with sales of $2.69 billion in 2010.[1] Garmin has streamlined the navigation process by developing and marketing intuitive portable navigation devices (PND) for cars, planes, boats and pedestrians. The company sells its products directly to original equipment manufacturers such as automakers and airplane manufacturers, as well as to consumers through mass retailers like Wal-Mart Stores (WMT), Best Buy (BBY) and Amazon.com (AMZN). Chairman and CEO Min Kao owns about 23% of Garmin.[2]
The consumer GPS market was once limited to the wealthy, but increased competition from low-cost overseas manufacturers, such as Tawain-based Mio Technology Corporation, in combination with Garmin's engineering and manufacturing expertise has helped to bring the cost of GPS devices to an affordable level. Garmin sells its products through a network of distributors such as Best Buy, Wal-Mart, and Costco, making its sales dependent upon the business of those retailers. Its network extends to 3,000 independent retailers in approximately 100 countries sell Garmin's consumer products.
The company faces significant challenges to extend its dominance to other markets. In the US, Garmin commands a 47% market share. However, in Europe, Garmin only has a 26% market share. Europeans have enjoyed the conveniences of GPS devices for a considerable time, and as a late entrant, Garmin faces stiff competition from incumbents and new market entrants.[3]
Garmin is the leading manufacturer of global positioning system (GPS) devices worldwide. Most of these devices are enabled by Global Positioning System (GPS) technology. Garmin offers a wide range of hand-held, portable, and fixed mount GPS-enabled products and other navigation, communications and information devices to the aviation and consumer markets. Access to the satellites for the GPS is provided free of charge by the US government.
Garmin's two target markets are the aviation market, which includes panel mount and portable products for general aviation aircraft, and consumer segment, which primarily includes products geared for marine, recreational, fitness, automotive and personal digital assistant (PDA) use.
Garmin designs, develops, manufactures, and sells global positioning system (GPS)-enabled products and other related navigation, communications, and information products worldwide. Its business is comprised of four distinct segments: Automotive/Mobile, Outdoor/Fitness, Marine, and Aviation.
Garmin offers a wide variety of built-in and portable electronics for the marine market. Its product line includes GPS chartplotters, sonar fish-finders, real-time weather receivers, sounders and radars. This segment captures over 30% of the total market share.
\ Garmin.
Garmin started off as an avionics company and remains the leading player in the sub-markets where it has chosen to compete, including the emerging micro-jet space. Garmin's venerable aviation unit builds devices for use in aircraft cockpits, enabling GPS-based navigation, very high frequency (VHF) communications transmitters/receivers, multi-function displays, receivers, and more.
With a signification proportion of revenue invested in R&D, Garmin has outmaneuvered perennial electronic leaders such as Sony (SNE) that have attempted to make forays in the GPS market. The company has not only been able to produce three times as many PND models as its closest competitor, but has also received consistent high praise from consumers for the ruggedness and user-friendliness of its products. Garmin's PND product portfolio is occasionally criticized for being too broad, and lacking focus, but in a high-growth, relatively young market, a broad portfolio provides Garmin with a chance of hitting upon an unexpected blockbuster.
Global penetration rates for GPS devices are very low; around 10% of the 35 million new cars projected to be sold in Western Europe and North America came with pre-installed GPS systems leaving a large potential consumer base looking for after-market GPS solutions.[5] Of the 430-450 million cars on the road in North America and Western Europe, only about 3% had in-dash navigation systems leaving Garmin with an addressable market of well over 400 million vehicles.[6] The market will only grow as manufacturing volumes increase and price points fall turning GPS systems into an affordable gadget.
GPS prices have fallen quickly over the last two years and will continue to do so. As key components, such as semiconductor chips and LCD displays, drop, companies will compete more on price since key features (text-to-voice, bluetooth) will become standard in an increasingly commoditized industry.
To fight against commodization, GPS companies have also begun loading devices with new features such as real-time traffic and weather data along with more in-depth information on restaurants, hotels and gas stations. [7]
Black Friday (day after Thanksgiving), the biggest sale day in the United States, exhibited the GPS manufacturers inclination to drop prices to attract business. Manufacturers cut prices on selected items by 35 to 50%. TomTom, Mio and Navigon chose essentially to discount their entry level device while Garmin and Magellan adopted another strategy with sales at different price points in their product range. [8]
The shrinking fossil fuel supply combined with the growing energy demands from developing countries, such as China, has dramatically driven up fossil fuel prices. China's demand for fuel is projected to increase by 150 percent by 2020, a rate of 7.5% per year, seven times faster than the U.S. As a result, drivers are trying to find solutions to reduce fuel consumption and save time. A recent poll conducted by Circuit City found that 72% of drivers believe that a GPS system can help them save time and lower fuel costs. The impetus to purchase a GPS system will only increase as gas prices rise.[9]
GPS devices will primarily be sold through electronics retailers and websites, channels that larger consumer electronics manufacturers know quite well. As the GPS markets tracks towards mass-market adoption, there is an expectation for large tradition consumer electronic manufacturers to view the space as incrementally more attractive because they can begin to gain economies of scale in manufacturing. With more competitors and increased pricing pressure, Garmin along with other competitors will face margin compression.
GPS is now competing with smartphones that have turn-by-turn directions and GPS-enabled features. Smartphones have become a large portion of the cell phone market. These phones, made by companies such as Apple, RIMM, and Palm, have stolen market share in the GPS market as well because they possess the capabilities to give users directions. Google has also introduced free navigation systems for mobile phones.[10] The cell phone service providers have given users the ability to download applications on to their phones that provide directions. This hurts Garmin's future prospects because as smartphones become more and more popular because consumers will have no reason to buy a GPS device in addition to their smartphones. Sales of Garmin's own smartphone (Nuvi) product category contributed only $27 million in revenue during the quarter. Those products have been on the market for a very short period time. The problem is that there are very few of those phones being sought after in a world of BlackBerry, Droid, and iPhones.[11]
Garmin faces heavy competition with a maturing market and declining prices on GPS devices. Garmin faces direct competition from TomTom, Magellian, and Mio. In addition to direct competition, big consumer electronics companies like Sony (SNE) and LG Electronics have begun to introduce GPS units of their own. Garmin has retaliated with an increase in R&D spending.
Garmin is ranked number 5 in the Consumer Goods sector (after competitors such as Whirlpool, Prestige Brand Holdings, Power One, and Wabash National), as measured by relative performance, a comparison between a share and its peers.[12]
PND is also threatened by cellular phones, several of which now have GPS capability. Garmin has a GPS mobile phone named Nüvifone. However, established competition like Nokia (NOK) and Apple (AAPL) led to lukewarm reviews and customer response for the Nüvifone. A brief description of the company's main competitors is listed below:


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Hi guys just thought I'd update you.
We were at our latest paediatrician app yesterday and the upshot is their willing to move forward for assessment.
I think I'm still in shock to be honest, I never thought we'd get to this day, it's been a long 3 years of trying to persuade professionals to listen. I'm so thrilled with the outcome, it would seem we're finally progressing forward.
They've apparently changed the way the assessment process is managed here in Scotland, it's now renamed APP with reduced waiting times from 3 years to 18 months. The main difference is that the assessment process is no longer within the schools. The assessments are now held at the hospital and children can now be referred to the pathway with or without school agreement. They have an initial assessment then depending on the outcome they will then take the path that's best suited to them.
For example as school aren't in agreement with L having any Asd traits then he will go straight to the FAST team for assessment, there are a couple of other routes depending on the needs of your child and if school are in support etc.
I'm sure it's a little more in-depth than I'm explaining but I just got made aware of the pathway that L will most likely take. I'll update when I receive more information further along in the process.
We've also been given melatonin slow release to try help settle him bettter during the night, I'm now unsure has anybody any experiencie with this, is it a positive and are their any adverse effects?
It's odd I was so hyped about it all yesterday, today I feel quite low, is this a normal response?
Tracky1 xx
Finally Referred On To Asd Pathway...
Started by tracky2 , Mar 15 2018 01:54 PM
1 reply to this topic
Posted 15 March 2018 - 01:54 PM
Posted 15 March 2018 - 07:00 PM
Sounds positive.
I think your reaction is quite normal as you spend so much time and energy to get people to recognise you concerns and then when they do the reality its you. So the high comes from succeeding, and the low from the new reality.
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