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All too often an existing home has far too little attic ventilation and some difficult choices for adding more. We all know the existing, although somewhat old, method of one ft² of net free vent area (NFA) for every 300 ft² of attic floor space and double that if the ceiling plane has not been well air sealed. Whatever that number comes out to be should be roughly divided half high and half low. 60/40 and 40/60 cold country vs ac country are options. But when you are short on vent area and cash, here is a detail not often mentioned.
The NFA is only part of the ventilation equation. The other half is the pressure across those vents. A 10 ft attic will have twice the attic stack pressure of a 5 ft attic. Now, I would have to do a bunch of reading to find out what height attic those old calculations were based upon, but a simple fudge factor would be, short attics need more and tall attics may get by with less.
Feel free to post any references that show how to adjust for attic height, fudge is good but real numbers taste better.
Views: 3220
I never fail to learn something from the information that Mr B Poll provides. Thanks again from St.Louis! Go Cardinals!
I'm convinced the attic height is a big factor. Have a problem I need to address. New cabin in mid Michigan having problems with ice dams. So large they knocked off commercial grade gutters last year. Cabin is 30x60 with 4-12 pitch and 3-12 vaulted ceilings. 7 skylights, 3 solar tubes, 16 IC can lights into the attic space and a high efficiency wood burning fire place so lots of heat sources going into the attic. 18"-24" insulation through out and built with energy trusses. Skylights wrapped with insulation. For ventilation, soffits are vented their full length and width and baffles run in every gap between the trusses. Ridge vent used but we get quite a bit of snowfall here. Bottom line, I'm convinced that I am not getting enough air exchange due to the short attic height. Considering adding gable vents but I've seen mixed reviews on their effectiveness. Thought I may need to go with a power vent. Planning pulling off the gutters rather than installing a very expensive heating system. Winter is quickly approaching so I need to make a move...any suggestions? Thanks.
Hi Mike,
Air leakage into that vaulted attic is probably your number one issue. The IC recessed lights need to be AT as well. They may be, but test them to see if air is leaking past.
I see T&G pine on the ceiling. That is a potential problem area, even with plastic under (over) it. The plastic is often stapled up with lots of resulting holes.
Your pictures are showing you where heat is getting into that attic space. With a 2 1/2 story, the pressure at the ceiling is high, so a really good effort at sealing is needed. But to be honest, access issues and that T&G will make it difficult.
Power venting will depressurize the entire attic which may remove more heat, but will also pull heat and moisture through any remaining leaks. Adding gable vents would increase the air coming in the soffits, but not enough to make a real difference.
Make sure bath and kitchen vents are blowing to the outside and not into the attic.
As a last resort, if this years fixes do not solve the problem, remove the snow after every storm.
That will get you started. I'm sure others will add their advice.
Following on Bud's comments - How you define problems tends to color the approach used in design solutions.
Einstein said something about how if he had 60 minutes to save the world, he's spend 55 minutes thinking about the problem. Rushing to solutions helps insure you'll get continuous work, and nothing fixed.
"Keep Roof Colder" leads to either ventilate more, or to "why is the roof warm?" Maybe efforts should directed toward not heating the roof in the first place. Stack and depressurization driven leakage from the house to the roof deck once diagnosed and addressed might avoid a lot of "poke n hope".
I do not think NFA is your "cabins" biggest problem. With there being so much insulation between a 3-12 ceiling & a 4-12 roof the only area to ventilate is the upper 1/2 of what little "attic" there is. Having lived in the Western NC area I can see some issues a builder or architect might overlook. Only having a continuous soffit & ridge vents won't do when the house is on a hill side surrounded by trees! If the home was between two ridges with the winds moving up or down that slope most of the year you might get away with it. The photos. tell me that is not the case. You cannot rely on static pressure or the thermal rules to move that much air. It needs some help. From VA down to the tip of FL, gable vents aren't an issue; they are going to be there unless you have a hip roof (like mine). The reason - who knows from where the wind comes & where it is going? In your case unless it is flowing up/down that slope your attic's NFA #'s aren't going to be the whole answer. If the wind is moving across the slope gable vents will assist in the pushing/pulling air through the attic. Turbines may help. Solar powered attic fans may be the best overall solution though (locate them on the South facing roof). Your surrounded by trees! They block wind flow & add moisture to the surrounding air. Houses surrounded by trees (close to the dwelling) typically have more mold/mildew issues, etc...
The issue that jumps out at me most is you appear to have balloon framing in the walls. The roof shows less snow on the upper half and directly above the outer walls. That lower area indicates a possible combination of air sealing & thermal (stack effect) issues. I'm wondering if the builders air sealed and insulated the juncture of wall to ceiling joists and rafters (using Energy Star, BPI, RESNET, etc. standards). A thermal scan of the home coupled with blue prints, building materials list & how those junctions were constructed may be very revealing! The fix - if that is the cause can be addressed by going into the eave & upper portion of the wall & finishing it right.
Pics 19 & 21 also show the grounds slope along what I take to be your garage. My experience of living in the mountains tells me your will have some water issues. The garage, back door threshold and possible under the siding into the living area may be future problem areas of water penetration. The ground slope HAS to be down and away from anyplace you do not want the water to penetrate! It isn't a good situation once it happens. Water issues in homes don't usually show up until someone smells the tell tale odors. The water running down from the hill sides behind & on the sides need to be channeled away from your garage & house foundation!!!
God Bless you in your new home.
Thanks for the insights. What appears as balloon framing I guess essentially is that on the front of the cabin. The entire front of the structure 30'x30' is open from floor to ceiling. Few more shots attached (I was glad when I got all the pine up with out incident!). My builder suggested the solar vents as a remedy but what about the snowfall? Big storms bring it in by the inches per hour...that's why we are there. My unheated garage usually has 12 to 24 inches on it from late Nov until early May. The turbine sounds interesting. I checked and all can lights are AT and IC. My next step is to get the scaffolding back out and spray foam all openings around can lights and at the joint between the wall and ceiling. I have a vapor barrier under the pine but yes, it is full of holes where I nailed in the pine. Thought another coat of Poly might do some good but a tough task so it would be a last resort.
Relative to ground slope, the appendage on the cabin is actually the original structure...kitchen, dining and two bedrooms. Grading on the back side is being addressed. I have all the water captured in the gutters and routed underground down the hill, that is why I would really want to keep the gutters up so I do not create a different problem.
If I had to name your problem, from what I see it is air leakage into the attic. The height of the building will result in a high pressure across the ceiling to attic boundary. With only plastic above the pine, it expands every time the pressure in the house changes, doors open and close, the wind blows or the temperature varies. Essentially, the flexible plastic pumps warm air into the attic. Between the staples and nails, combined with all of the lights there is probably a 6" equivalent hole from house to attic. 24/7 that will move a lot of heat up there.
Baffles help to keep the insulation out of the soffits, but at the expense of air flow. It works when the ceiling plane is well air sealed, but static ventilation cannot handle a leaky ceiling. Adding gable vents will increase the air flow somewhat and will increase the natural pressure at the soffits. But I don't think it will be enough to end the ice dams.
That large air cavity formed by the web trusses between the first and second floor will feed air into any electrical or plumbing holes that were not sealed and behind any wall coverings not glued air tight.
Is your attic insulation fiberglass?
Before spraying those can lights do some research1st. Some have to vent their heat - some don't. If they do have to be vented there are manufacturer directions on air sealing/insulating, yet allowing them to vent at the time. The holes in the vapor barrier. Assuming the ceiling is T&G, wouldn't the planks & barrier be drawn up tightly to the rafters?! The new pics show it is balloon framing. Stack effect is more pronounce in these walls. Did you air seal & insulate the outer wall under that 2nd floor? Air will infiltrate between those joists under that floor at a faster rate than at a sill plate. We see it here in SC all the time and we never have the lower temps. you have. Good luck.
You can't ignore the effect of the prevailing wind which has a MUCH bigger impact that the natural draft that occurs from temperature differences.
Net free area also has it's issues, especially with ridge vents. Net free area on ridge vents does NOT take into account the very restrictive "filter" present in most designs. And what happens when the filter loads up from dust caused by the airflow?
A simple hole cut 12x12 is NOT the same as 144sqin "net free area" on a vent that requires the air to make multiple turns before exiting. Back pressure is created anytime you force air to make 90 degree turns.
Bob, I agree.
I just want to add, when the wind blows, ventilation usually gets better and that is good, except when it brings in rain or snow. Getting the static ventilation to work is a worst case design.
As for NFA, it is hard to trust the mfg numbers. About 12 months ago I took your question directly to the top dog of the roofing ventilation group. * Using the opening area and not accounting for the filter material the air has to pass through seemed a bit of an exaggeration. He was blunt and insisted they used an approved standards testing organization to determine that number, end of conversation. The bottom line is, NFA is directly related to the calculations we do and we really should have a high degree of confidence in their number, I don't. There are other NFA numbers that seem to vary widely, but I think I'm too low on the totem pole to be able to suggest improvements.
*18 square inches per linear foot with a 3/4" opening on each side, hmmm!
A 12" roof turbine is rated @ 113sqin, and IMHO it moves every bit of it. Enough airflow moves through the turbines to turn the vent even when the wind isn't blowing!! When the wind blows the turbines really move the air. Unfortunately they do poorly in the aesthetics department and you don't see them much anymore, form over function.. Just upsize the AC unit and call it a day...
"Whirlybirds"... I've got a pair on top of my house, they are on the back slope of the roof so they really can't be seen from the street. They are such a common item around here aesthetics usually isn't an issue. Don't see too many new homes with them though.
Mine are on the same plane, and equidistant from the roof ridge. Interestingly, there are times when one is spinning away and the other is barely moving. Most of the time, thanks to onshore flows and the usual amount of late afternoon wind we receive in this area, they are pretty much moving most of the late afternoon and a bit after sunrise. Never had a problem with moisture getting in either. I've been in attics where the 'birds were frozen (as in not moving) and haven't run into any moisture issues in those either.
Warm dry climate, no snow, mild winters
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Smolemon Links...Comics & Blog
The Current The Ex
Smolemon likes...Riot Not Diet
Dan Head
Silent Studios
Webcomic Factory
Super Frat
Smolemon Links...Comics & Blog
Smolemon likes...Riot Not Diet
Well, do you, punk?
What if I could tell you the secret to being lucky? All it will cost is a change of perspective and £10 a month paid directly to me ... ok, whatever, I'll let you be lucky for free. I'm generous like that. Most people measure Luck on what is happening in the present and what they want to happen in the future...
For example: "Currently, I want more money ... So I will buy a lottery ticket ... if I'm lucky I will win in the future."
Well that is all well and good if you do win, but I'm betting that you won't ... and then you will feel unlucky. So do you feel lucky right now?
When I was out and about recently (That's why there's been no blogs and comics for a while, I've been let out of the house) I was stood on a bridge and enjoying the view below. Suddenly I thought "what if a gust of wind blew me off this ledge now" (cos I'm cheery like that). No gust of wind materialised, I was never in any danger, so why should I feel lucky? Answer the question below and I'll explain after ...
There's a man on a cliff edge. A strong gust of wind blows the man into the water below and he drowns. Suppose in a parallel universe the wind isn't as strong and he lands on a rock below, severely breaking his bones but it's not a fatal fall. Then in another universe, no gust of wind appeared and he carried on his life never knowing the other outcomes of standing on that cliff. Which version of the man is the luckiest? Which version of the man FEELS the luckiest?
Well obviously the luckiest guy is the one that went home without the broken bones or dead (Just assume he wanted to carry on living ... don't be morbid).
But the one who FEELS the luckiest is the one that almost died but didn't. He can look back on the event and say ... "I was lucky I didn't die".
MIND=BLOWN right?!?
So I guess what I'm saying is that you should constantly think that you are going to die any minute and you will be the luckiest person in the world until you do actually die. No, wait, that doesn't sound right.
The best way to explain is to think about what you do have currently and not what you want. Take the lottery ticket example from before ..."Currently, I want more money ... So I will buy a lottery ticket ... if I'm lucky I will win in the future."
And change it to ...
"I have enough spare money after paying for rent and food to purchase a ticket that could earn me even more money ... so why not try it ... it doesn't matter if I win or lose, I'll still have what I have"
If you look at what you have and not what you don't have ... you'll feel lucky. Give it a try.
Do you feel lucky?
I went to a very interesting talk about dinosaurs the other week (strangely not the geekiest thing I have said today).
After the presentation we went out for a meal and our conversation turned to ducks (naturally). Specifically the mating rituals of ducks; apparently they are a bit ... rapey.
The image below is what I had stuck in my head since that conversation; this week I finally got around to creating it.
If you want to know more about this topic (you sick f*ck) then go check out the awesome article I found on Cracked.
I've always been creative, even from a young age.
Seriously, I can prove it!
When I was at my mum's house over the weekend I found an old school workbook full of stories I had written when I was 10 years old.
I have decided to share my favourite story with you (with the original spellings and grammar intact). The following story is called ...
..."It Is True"...
"Well what happend was, I woke up and there was a knock at the door so I went down stairs and there was two men at the door
One was tall and thin and he had black hair and the other one was short and plump with brown hair they looked very soureos. But I opened the door and let them in. they got out a drill from there pocket and started to drill a hole in my wall right under the telephone table and they knocked the wall out then pulled out a picture and siad this is the famous wriggle bottom and then they left.
The picture had a boy on a chair at school whith a red stress ball in his hand.
When I set of for school down a greate I saw a blue and green flashing light so I lifted the grate up and saw a big brown monster whith flashing blue eyes and a supens tale. The monster cheasd Me all the way to Doncaster and back then he got tired and went down a grate."
Now, I don't remember if any of this story is true or not. I mean I don't remember any of it happening. Maybe I repressed the memory of letting two strangers in my house who proceeded to drill my walls and show me the famous wriggle bottom?
Just how did the Wriggle bottom get famous in the first place?
If this is a repressed memory ... I think it's best staying that way.
Earlier in the week I posted a blog and podcast about the Eurogamer expo last weekend. In the blog I mentioned a zombie makeup artist doing promotional work for Dead Rising 3.
Jason Wright is the Creative director for 'Silent Studios'; who describe themselves as a "PR Promotional Photographic and Production Team that specialise in extreme horror and gore".
The zombies I saw were looking great (great as in very dead and gory). Jason Wright certainly takes pride in his work. He excitedly explained to me that all the zombies at the expo were based on the zombie characters from the new Dead Rising game (He was most proud of the zombie with a saw blade stuck in his rotting torso).
I've added Jason to the list of 'awesome people I've met this year'; a list that resides only in my brain (zombies would love it).
The whole zombie team seemed to put all their effort into the show and had a great time freaking out the crowd. I'd love to be involved in that actually, I'll put myself out there now ... need a free zombie extra at any time? ... I'm up for it! (I'm being DEADly serious).
If you want to know more then check out the Silent Studios website.
But there wasn't just a horde of professional zombies ... there were also a whole bunch of cosplayers in the crowd. Cosplay (short for costume play) is basically all about dressing up like your favourite fictional heroes.
So I thought I'd do a list of my favourites I saw at Eurogamer 2013.
Joint 3rd place - If anyone can tell me what the first one is meant to be then let me know ... some sort of space bride? Anyway, I liked her conviction. The second one is Harley Quinn from Batman, I liked the fact that she kept getting hassled for photos but nobody wanted her boyfriend in the picture, also I liked that I couldn't get a photo with her eyes open. The final one is DC's Deathstroke (I used to have a girlfriend that I gave that nickname).
2nd Place - Earthworm Jim costume, simply because it took me back to my youth ... Groovy. The other guys in this are good too (scarecrow and female joker). They can be runners up too.
1st place - Goes to the Judges from 2000AD's Judge Dredd. These guys were much fun.
Can you beat these cosplay guys? Then send me a picture on the Smolemon Facebook page or to @smolemon on twitter.

subset: commoncrawl


text:
Dose Escalation Study of Pazopanib Plus TH-302 (PATH)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01485042
Recruitment Status : Completed
First Posted : December 5, 2011
Last Update Posted : September 1, 2017
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
3 STUDY RATIONALE Based upon the above rationale, the investigators propose a phase I study combining Pazopanib with TH-302 in advanced solid tumors. Pazopanib is FDA approved at a dose of 800mg per day. Using this dose ensures consistency with standard clinical use. It also ensures using the dose most likely to induce maximal hypoxia, which in turn will help ensure maximal local activation of TH-302 (a hypoxia activated prodrug). TH-302 can be given as monotherapy at a weekly dose of 575 mg/m2. When TH-302 is combined with full doses of various chemotherapeutics, the recommended dose of TH-302 has ranged from 240 to 480 mg/m2. Little overlapping toxicity between TH-302 and pazopanib is expected. However to ensure patient safety, the starting dose for the combination will be conservative and use the TH-302 dose found safe with the majority of cytotoxic agents, 340 mg/m2 given days 1,8, 15 on an every 28 day cycle.
Using a standard 3+3 design, the investigators will add increasing doses of TH-302 (340 mg/m2, 480 mg/m2, 575 mg/m2 given weekly, 3 weeks on/1 week off (the standard TH-302 dosing schedule) to the full monotherapy dose of pazopanib (800 mg p.o daily) with expected accrual ranging from 12-18 subjects. Once the recommended phase II dose is identified, the investigators will then enroll an expanded cohort of approximately 12-18 (i.e. total of 30 subjects overall) patients to better define the tolerability of this study drug combination.
4 STUDY OBJECTIVES 4.1 Primary
- To define the maximal tolerated dose (if any) and the recommended phase II doses for the combination of pazopanib plus TH-302 in patients with advanced solid tumors 4.2 Secondary
- To describe any dose limiting and non dose-limiting toxicities of this drug combination
|Condition or disease
|Solid Tumors
|Drug: Pazopanib and TH-302
|Phase 1
Show Detailed Description
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|50 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Phase I Dose Escalation of Pazopanib Plus TH-302 in Advanced Solid Tumors
|Study Start Date :
|December 2011
|Actual Primary Completion Date :
|February 2013
|Actual Study Completion Date :
|March 2014
Experimental: Dose Escalation
This is a Phase 1 dose escalation with an expanded cohort that will enroll at MTD.
Drug: Pazopanib and TH-302
Pazopanib 800 mg daily TH-302 IV on Days 1, 8, 15 at MTD Subjects will receive this regimen until disease progression.
- Maximal tolerated dose [ Time Frame: 12-18 months ]To define the maximal tolerated dose (if any) and the recommended phase II doses for the combination of pazopanib plus TH-302 in patients with advanced solid tumors
- Dose limiting or non dose limiting toxicities [ Time Frame: 12-18 months ]To describe any dose limiting and non dose-limiting toxicities of this drug combination
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Histologically and/or cytologically confirmed malignant solid tumor that is refractory to standard therapies, or for which no standard therapies exist, or for whom pazopanib would be considered a therapeutic option.
- Disease must be measurable by RECIST 1.1 criteria (see Appendix 1).
- Age ≥ 18 years
- Karnofsky Performance status ≥ 80% (see Appendix 2)
- Life expectancy of at least 3 months
Adequate bone marrow function as shown by:
- ANC ≥ 1.5 x 109
- Platelets ≥ 100 x 109/L
- Hemoglobin ≥ 9 g/dL; Erythropoietin and transfusion support is permitted provided treatments are not required more than every 8 weeks. Hemoglobin must be stable above or equal to 9 g/dL for at least 2 weeks prior to day 1of study drug without blood transfusion to maintain hemoglobin level.
Adequate liver function as shown by:
- serum bilirubin ≤ 1.5x ULN
- PT/PTT/INR ≤ 1.5x ULN
- ALT and AST ≤ 2.5x ULN
- Adequate renal function: creatinine clearance (estimated) ≥ 50 cc/min by Cockroft-Gault or 24 hour urine (see Appendix 6).
- Baseline MUGA or ECHO must demonstrate LVEF ≥ 50%
- TSH, T3 and T4 within normal limits; Patients are permitted to receive thyroid hormone supplements to treat underlying hypothyroidism.
- Women of childbearing potential (WOCBP) must have a negative serum pregnancy test within 7 days from day 1 of study drug; both men and women must be willing to use two methods of contraception, one of them being a barrier method during the study and for 6 months after last study drug administration.
- Signed informed consent
Exclusion Criteria:
- Patients currently receiving anticancer therapies or who have received anticancer therapies within 4 weeks from day 1 of study drug (including investigational agents, chemotherapy, radiation therapy, antibody based therapy, etc.)
Patients who:
- have had a major surgery or significant traumatic injury within 4 weeks from day 1 of study drug,
- have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or
- are anticipated to require major surgery during the course of the study.
- Patients who have exhibited hypersensitivity reactions to pazopanib and/or a structural compound, biological agent, or formulation.
- Patients receiving chronic, systemic treatment with corticosteroids or another immunosuppressive agent with the following exceptions:
- Intermittent steroids (not to exceed 4 mg every day) may be used on an as-needed basis
- Patients on physiologic replacement doses of steroids due to adrenal insufficiency for any reason may remain on these medications.
- Topical, inhaled or intra-articular corticosteroids
- Active brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases. Treated, asymptomatic metastases are permitted provided the patient has been off steroids for at least 1 month prior to day 1 of study drug.
- Severe chronic obstructive or other pulmonary disease with hypoxemia (requires supplementary oxygen, symptoms due to hypoxemia or O2 saturation <90% by pulse oximetry after a 2 minute walk or in the opinion of the investigator any physiological state likely to cause systemic or regional hypoxemia.
- Presence of poorly controlled atrial fibrillation (ventricular heart rate >100 bpm)
- Previous history of CVA, TIA, angina pectoris, acute MI or history of recent re-perfusion procedures (e.g. PTCA), pulmonary embolus or untreated deep vein thrombosis (DVT) within 6 months from day 1 of study drug.
NOTE: Subjects with recent DVT who have been therapeutically anti-coagulated for at least 6 weeks are eligible.
- Congestive heart failure (New York Heart Association (NYHA classification, see Appendix 4 functional classification III-IV).
- Proteinuria at screening demonstrated by urine analysis (UA) > 1+ or 24 hour urine protein ≥ 1 gram/24 hours.
Patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study as so judged by the treating physician. Examples include but are not limited to:
- Severely impaired lung function (e.g. use of home O2, history of Idiopathic Lung Disease (ILD), any evidence of ILD on scan.
- Active or uncontrolled severe infections requiring treatment with antibiotics.
- Liver disease
- Poorly controlled hypertension [defined as systolic blood pressure (SBP of >140 mmHg or diastolic blood pressure (DBP) of >90 mmHg] NOTE: Initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry. Following antihypertensive medication initiation or adjustment, blood pressure (BP) must be re-assessed three times at approximately 2-minute intervals. At least 24 hours must have elapsed between anti-hypertensive medication initiation or adjustment and BP measurement.
- Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of oral medications (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection).
- Significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent peripheral arterial thrombosis) within 6 months prior to day 1 of study drug
- History of hemoptysis within 1 month prior to day 1 of study drug.
- History of abdominal fistula or gastrointestinal perforation at any point within 6 months prior to day 1 of study drug, unless surgically repaired.
- Active peptic ulcer disease inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease), or other gastrointestinal conditions with increased risk of perforation or gastrointestinal bleeding.
- Use or need for full dose anticoagulation other than low molecular weight heparin (e.g. Lovenox and no other bleeding risk).
- Invasion or encasement of a major artery. Abutment without invasion or encasement is permitted.
- Serious, non-healing wound, active ulcer, or untreated bone fracture as judged by treating physician.
- Active, bleeding diathesis.
- Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage.
- Known history of HIV or Hepatitis B or C seropositivity.
- Female patients who are pregnant or breast feeding, or adults of reproductive potential who are not using effective birth control methods. Two acceptable forms of contraceptives must be continued throughout the trial by either sex. Hormonal contraceptives are not acceptable as a sole method of contraception. (Women of childbearing potential must have a negative serum pregnancy test within 7 days prior to day 1 of study drug).
- Concomitant use of CYP3A4 inducers, strong inhibitors or substrates with a narrow therapeutic window.
- Corrected QTc interval > 480 msec. If QTc interval is > 480 msec, then 2 additional ECGs should be obtained over a brief period of time (e.g., within 15-20 minutes) to confirm the abnormality.
- Patients unwilling to or unable to comply with the protocol.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01485042
|United States, North Carolina
|Duke Cancer Institute
|Durham, North Carolina, United States, 27710
|Principal Investigator:
|Herbert I Hurwitz, MD
|Duke University
|Responsible Party:
|Herbert Hurwitz, MD, Associate Professor of Medicine, Duke University
|ClinicalTrials.gov Identifier:
|NCT01485042 History of Changes
|Other Study ID Numbers:
|First Posted:
|December 5, 2011 Key Record Dates
|Last Update Posted:
|September 1, 2017
|Last Verified:
|August 2017
Keywords provided by Herbert Hurwitz, MD, Duke University:
Phase 1
advanced solid tumors


text:
Rhythm was the answer.
Its what the Fort Lewis College mens basketball team lacked as UC-Colorado Springs took a 48-46 second-half lead.
Its what the Skyhawks found in rolling to a 17-point win.
No. 22 FLC played better defense and found its way on offense over the final 15 minutes, pulling away for a 83-66 win Saturday at Whalen Gymnasium.
Trailing by two with 15:31 to play, FLC (17-4, 14-4 Rocky Mountain Athletic Conference) held UCCS without a point for 5 minutes, 31 seconds as part of a 29-6 run that saw the Skyhawks build the lead to 75-56.
FLC outscored UCCS 44-30 after leading 39-36 at halftime, and the Skyhawks shot a blistering 69 percent after intermission.
We always talk about if we play 40 minutes of Fort Lewis basketball, well have a great game, said Marcus Ayala, who led all scorers with 23 points. So staying composed is the main part, and playing our game is what helped us stay through it and get the ballgame out.
Alex Herrera was Mr. Inside to Ayalas Mr. Outside, scoring 21 points and pulling in 13 rebounds. Matt Mazarei had six assists against no turnovers as FLC assisted on 25 of 33 made field goals.
Herrera had to battle and really exert himself for points in a very physical contest, fighting through a sea of bodies and arms to make 9 of 13 field goal attempts.
Well, if theyre going to play physical, Im just going to play physical right back. Im not going to let it get in my head, Herrera said.
Fort Lewis turned up the heat defensively as well, holding UCCS (4-18, 4-14 RMAC) to 36 percent shooting in the second half.
We have pretty good depth, and in the second half, I thought (the bench) came in and gave us some energy, FLC head coach Bob Hofman said. I dont think theyre quite as deep as we are, and I think we wore them down a little bit, and I think our starters were able to come back in and play with a bit of an advantage.
FLC jumped out early, leading by as many as 13 in the first half. But a 12-4 run late in the first half was sparked by Alex Welsh, who finished with 17 points, and Derrick White did some of his 17 points worth of damage early in the second to help UCCS to the lead.
One of the cardinal rules of coaching is dont coach frustrated, Hofman said. And the team played, I thought, a little frustrated toward the end of the first half, and in the second half ... we were a little bit freer.
Looming next is the heretofore unbeaten Metro State, ranked No. 1 in the nation. Fort Lewis fell 71-65 to the Roadrunners last time, with the rematch set for 7:30 p.m. Friday at Whalen Gym.


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Creepy Andy Warhol Sculpture Imagines the Artist at 83 [VIDEO]
If Andy Warhol were alive today, how would he react to modern culture? The iconic artist, who died in 1987 at age 58, would probably flip for internet microcelebrities on sites like YouTube, which affirms his "15 minutes of fame" theory.
To commemorate Warhol's 83rd birthday this past Saturday, artist Edgar Askelovic created a sculpture that imagines what he would have looked like had he lived to see 2011.
The realistic, if creepy, rendering shows a Warhol that didn't age very well, but still dresses for the chic downtown art scene (no fuddy-duddy cardigans for this old fella).
Check out the making-of video below:
[via BBC]


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Coming Events...
A chicken barbecue will be held on Sept. 23 at Wyalusing's Penmart and the Laceyville Fire Hall. Chicken will be ready around 11 a.m. Proceeds are going to the Chris Brown Family to help them with daughter Abbi's medical expenses.
The Stevensville Community Club's last chicken barbecue of the season is Oct. 6 at the Stevensville Auto Body. Ready at 11:30 a.m. See Will to preorder chicken halves.
American Cancer Society Bark for Life. A canine event to fight cancer on Saturday, Sept. 29 from 10 a.m. until 4 p.m. at Towanda Riverfront Park. Dog walk, prizes, canine demos, booths, entertainment, food and more. Fundraiser to benefit the local American Cancer Society Relay for Life teams. Contact Roy Woodruff at 570-265-8497 for information.
Amish Pancake Supper and Bake Donation at door. Sept. 28, 4 to 8 p.m. at the LeRaysville Community Building. The benefit is for Raymond Mast's 3-1/2-year-old daughter, Sarah Beth. The family has a lot of hospital expenses including her feeding tube. If you can't come, feel free to make a donation to Raymond Mast, 1682 Cheesehouse Rd., LeRaysville, PA 18829. S38-2p/R38- 2p
Monthly Breakfast at the Herrickville Fire Hall, Sunday, Sept. 30, 2012, 7:30 to 10:30 a.m. All you can eat: pancakes, ham, sausage, eggs, coffee, orange juice and real maple syrup. Adults, $7; children to 12 years, $3; preschool, free. Benefit: Herrick Twp. Vol. Fire Co. - Dept. 4.
Sylvania/GTE Women's Club breakfast will be held at the Towanda Country Club on Wednesday, Sept. 26 at 8 a.m. Any employee is welcome to come and enjoy the fellowship. Any questions, call Bev Beers at 570-265-2963.
Susquehanna Singers will perform at Standing Stone Vesper Church on Sunday, Oct. 7 at 6 p.m. and Sunday, Oct. 14, 6 p.m. at the Franklindale Church. The public is cordially invited.
Susquehanna Singers Rehearsals will be held Sunday, Sept. 23 at 2 p.m. in the sanctuary of the First Presbyterian Church, 5 Court St., Towanda. New members are always welcome. Questions and more information, call Jody Stroud, 570-247-2456.
On Oct. 13 a Spaghetti dinner will be held at the Wyalusing Fire Hall from 3 - 7 p.m. The event 'Prayers for Abbi' is being held to help the Chris Brown Family with daughter Abbi's medical expenses. Tickets are on sale at Peoples State Bank, $5 adults; $3 kids.
The WVHS Class of 1951 will meet for lunch on Friday, Sept. 21 at noon at Mark's Valley View, Laceyville.
Flood Recovery Fundraising Dinner on Sept. 30, 5 to 7 p.m. at St. Mary's Hall in Wyalusing. There will be a presentation sponsored by Loaves & Fishes
Ministries, Inc. on the amazing volunteer work that has been done to date. Expenses for flood recovery have greatly depleted funds from several volunteer organizations, and there is still work to be done. The cost for the dinner will be a "free will donation."
The Skinners Eddy United Methodist Church will sponsor a "free" senior luncheon on Oct. 9 at noon. The menu is soup, sandwich, dessert and beverage. This luncheon is open to all seniors in the area. Good entertainment is always provided. Please call either Teresa Brewer at 570-869-1153 or Bonnie Jayne at 869-1938 to make a reservation. We don't want anyone to go away hungry.
LeRaysville Minstrel Show practices will begin Thursday, Sept. 20 at 7 p.m. at the Community Hall. New members are welcome. For more information, call 570-744-2636, 746-3154 or 744-1251. R38p
Quilts, Then and 22 and 23 at Lynch Bustin Elementary School, Athens, 10 to 5 on Saturday and 10 to 4 on Sunday. Over 300 quilts, Civil War quilt display, new 2012 Hoffman Challenge exhibit of Marilyn Belford's portrait quilts, bed turning of antique quilts paired with modern counterparts. Free parking, wheelchair accessible, vendors, food available. Cost, $5. R38c
For Your Information
To report animal abuse in Bradford County call (570) 888- 4763. You may also report stray or running dogs to the Bradford County Dog Warden by calling (570) 265-8191.
The Montrose Community Chorale will present their annual concert, on Sunday, Dec. 2, 2012, under the direction of David Andre at the Montrose Area High School at 3 p.m. If you are interested in singing with this group, please contact David Andre 570-278- 3469, Mary Ann DeWitt 570-278- 2791, Duane Hinds 570-967-2612, Louise Smith 570-278-1748 or Tom Pascoe 570-278-1054 by Oct. 1, 2012. Rehearsals begin on Monday, Oct. 22 at 7 p.m. at the Montrose United Methodist Church and include Wednesday night rehearsals.
Bookmobile Schedule Sept. 25, Bradford County Manor, 9:30 a.m.. Sept. 27, Sayre Hopkins Commons II, 9 a.m., Commons I, 10:30 a.m.; Sayre Keystone Manor, 1 p.m.; Athens Kozy Kastle, 3 p.m. Oct. 3, Park Place Apts., Wyalusing, 9 a.m.; Wyalusing Library, 10:30 a.m.; Sugar Run P.O., 12:30 p.m. Oct. 5, C&N Bank, Wysox, 10 a.m. to 2 p.m. Oct. 10, G&G Learning Center, NEB Schools, 9:15 a.m.; Stevensville P.O., 10:30 a.m. Oct. 15, N. Towanda Colonial Apts., 8:30 a.m.; Towanda Memorial Hospital, 10:30 a.m.; New Albany Library, 11 a.m. Oct. 22, BLaST IU 17, 9 a.m.; Monroeton Library, 11:15 a.m. Oct. 24, Sayre Senior Center, 9 a.m.; Sayre Library, 10:45 a.m.; Bradford Co. Day Care, Sayre, 1 p.m.; Page Manor, 2 p.m.
Salt Springs State Park Happenings: Sept. 29, Full Moon Hike; Oct. 13, Look at Those Leaves, 2 to 5 p.m. Visit website for more info., friendsofsaltspringspart.org. Located in Franklin Forks, PA.
Baby Buggy Decorating Contest
has been added to the Wyalusing Fall Festival this year. Trophies will be awarded to the prettiest, funniest, scariest and most original buggies. (A buggy is considered any vehicle that would transport a child: stroller, carriage, wagon, etc.). The festival will be held on Saturday, Oct. 13 from 9 to 4 with the buggy parade to be held at 2:15. Start now planning and decorating your buggy. Don't have a baby? Use a doll, we won't care. No pets allowed. For more information, contact the Chamber office at 570-746- 4922.
Lucky X Shoots
Lucky X Shoots at the Wyalusing American Legion Post 534 on Sept. 23, Oct. 7, Oct. 21, Nov. 4 and Nov. 18, starting at 12:30 p.m.
Meeting Notices
S.O.S. Al-Anon — Family Group will meet on Fridays at 7 p.m. at St. John's Lutheran Church, Hopkins Street, Sayre.
Recovery House Meetings — AA Group of Towanda meets Mon.-Fri., noon; Mon., Thurs., Fri., Sat., 8 p.m., Sun., 8 a.m. and 8 p.m. NA meetings are held Tuesdays at 7 p.m. Speaker meeting every first Sunday, 8 p.m. All meetings at 205 Main St., Towanda (please use rear, lower entrance).
Compassionate Friends — of the Endless Mountains will hold their meetings on the second Tuesday of every month at 7 p.m. in the Endless Health Community Center, Montrose. TCF is open to all families who have lost a child from any cause at any age. There are no membership dues or fees of any kind. For more information, call 965-0901 (evenings) or 278-1658 or e-mail firstname.lastname@example.com.
Caregivers' Support Group sponsored by the Law Office of Leslie Wizelman and the B/S/S/T Area Agency on Aging meets at noon the second and fourth Tuesday of each month at the Library at Memorial Hospital Personal Care Home in Towanda. Anyone taking care of a family member or loved one, be it at home or as a resident of a long term care facility is welcome. For information, call Donna Benjamin at the Law Office of Leslie Wizelman, 570-746-3844 or Sue Roy at Area Agency on Aging, 570- 265-6121. The next meeting will be Tuesday, Sept. 25.
Twelve Steps on the Way, a Christian recovery group, will meet at the Wyalusing Presbyterian Church on Mondays at 7 p.m. Use door in the rear of the church.
Al-Anon meetings in Tunkhannock: Endless Serenity Al-Anon Family Group on Monday, 7:30 p.m., Wednesday, 7 p.m., Saturday, noon. All meetings are held at the Tunkhannock UM Church Education Bldg., second floor.
Diabetes Support Group - meeting the first Thursday of every month at the Guthrie Clinic office in Towanda beginning at 5:30 p.m. There is no charge and all diabetics and family members are welcome. For more information, call Dawn at Guthrie Clinic at 570- 265-6165 during regular business hours.
TOPS PA #1134 — Laceyville, meets each Tuesday evening at the Braintrim Baptist Church in Laceyville. Weigh-ins from 5:15 to 6 p.m., meeting from 6-7
p.m. For more information, call 965-2493 or 869-1834. Toll-free 1- 800-932-8677.
AA Meeting — Wednesdays at 8 p.m. in the basement of the Wyalusing Presbyterian Church. Open meeting, nonsmoking.
MOPS — Mothers of Preschoolers meet every first and third Wed. of the month from 9 to 11 a.m., September through May. Meetings are held at the First Presbyterian Church, 5 Court St., Towanda. All mothers of preschoolers are welcome. Child care is provided for children, ages infant through five years old. For more information, contact the church at 570-265-5575.
Towanda-Wysox Kiwanis Club meets every second and fourth Wednesday of each month at the Weigh Station Café at 7:30 a.m. in Towanda. They find ways to help the children in the community. Contact Eileen Sheets at 570-265-2350 for more information.
Addictions to Victory. Faithbased support for addictions. Program will be held the first and third Thursday of each month at 7 p.m. at New Generation Church, Milan, 570-888- 1967.
Bradford County Cancer Support Group meets the 4th Wednesday of every month at Memorial Hospital in Conference Room A, beginning at 6:30 p.m. For more information, call 1-888-227-5445, Option 3.
The Wyalusing Masonic Lodge No. 618 meets at 7:30 p.m. on the third Monday of each month at the Lodge Hall, 158 Church St., Wyalusing. For more information, call 570-721- 0008.
Twin Tier Antique Tractor and Machinery Assoc. will meet on Thursday, Sept. 20 at 7 p.m. at Stoll Building, Wysox.
Dr. Philip Lowry, Chief of Hematology/Oncology at Sayre Guthrie Cancer Center will be the guest speaker at the Bradford County Cancer Support Group meeting on Wednesday, Sept. 26 at Memorial Hospital, Towanda. The meeting begins at 6:30 p.m. in Conference Room A. All cancer survivors, patients and caregivers are welcome. Please call the American Cancer Society at 888-227-5445, option 3 for more information.
The North Flat Cemetery Association will hold a special meeting on Sept. 22 at 1 p.m. at the Windham Township building to discuss cemetery business.
PSEA-Retired Fall Meetings now happening, Endless Mountains Chapter, covering Bradford, Sullivan, Susquehanna and Wyoming counties will meet Wednesday, Sept. 26
at the Villa Sena, Towanda. Meeting starts at 11:30 a.m. Lunch off menu. Make reservation by Friday, Sept. 21 by calling Agnes Massacesi at 570-836-0173.
On Sunday, Sept. 23, the Bradford County Historical Society will hold its annual membership meeting at the museum located at 109 Pine Street in Towanda. The event will begin at 2 p.m. in the Great Room of the building. The program will be followed with light refreshments. Call the museum at 570-265-2240 to reserve your seat for the annual meeting.
Empty shelves at the T.A.C.O. Food Pantry. Due to very heavy demand this summer, combined with cutbacks in State funding, T.A.C.O. Food Pantry finds itself in need of donations. The pantry is located at 1876 Golden Mile Rd., Wysox, PA and is open Monday, Wednesday and Friday from 10 a.m .until Noon. Mailing address: PO Box 463, Wysox PA 18854. Phone 570- 265-4422.
Towanda Class of 1972 is celebrating the 40th anniversary of its graduation the weekend of Sept. 28 to 30. Events include a tour of newly-remodeled high school building, attendance at the homecoming football game, wine tour with bus at two local wineries, dinner at the Towanda American Legion and Sunday church service. Class members may attend any of the events and can make reservations for dinner with Keith Long, 570-265-8116 before Sept. 24.
Wyalusing High School Wrestling Booster Club will hold a meeting on Wednesday, Sept. 26 at 6 p.m. in Coach Haley's room at WVHS. Voting for new officers at this meeting.
Kids' Obstacle Course for fun will be run on Saturday, Sept. 22 at Grovedale Winery at noon in conjunction with the North Branch Triathlon. There is no cost to participate and kids do not have to have someone participating in the triathlon to run the course. Kids from 3 to 11 should be at the winery patio at noon. Small prizes will be given.
Turkey Shoot
VFW Post #6824, Fall Turkey Shoots, noon to 4 p.m., Sept. 16, 23, 30, Oct. 7, 14, 21. Lucky X, Shotgun Shoot, Food, Showdown, 50 Cent Bingo, Pull Tabs, Raffles, 1468 Haighs Pond Road, Rome. R36- 7c/S37-6c
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About Emma Watson(Click Here To Hide)
Emma Watson is an English actress best who played Hermione Granger on the Harry Potter series. Emma Watson's success in the Harry Potter series has led to several more projects and helped Emma Watson win the UK Kid's Choice Award.
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Item 2 of 20
Baseball game, Houlton, ca. 1895Item 13600 info
Aroostook County Historical and Art Museum
Houlton versus Portland Baseball Game in the Park on North Street. Houlton is in the field. Dr. Miles Cochran is the umpire.
Note the grand stand and pavilion
This photograph was taken by (Edward) E. B. White, a jewelry merchant and skilled amateur photographer.


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Police: 12 dead in shootings at UN Navy complex
WASHINGTON (AP) — A shooting rampage in the heart of a U.S. Navy complex in Washington left at least 12 people dead Monday. One shooter was killed, but police were looking for one other possible gunman wearing a military-style uniform.
President Barack Obama said he is mourning "yet another mass shooting" and called it a "cowardly act."
Officials said at least four people were wounded — three critically — in the rampage at the Washington Navy Yard, including a law enforcement officer.
Federal law enforcement officials identified the shooter as Aaron Alexis, a 34-year-old Texas man believed to have a criminal record there and said he may have gotten into the Navy Yard by using someone else's identification card. The two officials spoke to The Associated Press on condition of anonymity because they were not authorized to speak publicly.
The shooting led to tightened security at the Capitol and White House nearby, including shutting down the Senate while a possible remaining shooter was sought. D.C. Police Chief Cathy Lanier announced the death toll and said people were being told to stay in their homes and out of the area.
Lanier said there was no indication of a possible motive.
The shooter was a Navy employee whose work status had been changed earlier this year, said a federal government official who spoke only on condition of anonymity because he wasn't authorized to speak on the record. While that may suggest the motive was job related, authorities haven't ruled out anything including terrorism, the official said.
Police said a man in a tan, military-style outfit who had been sought in connection with the shooting had been identified and was not a suspect or a person of interest in the slayings. The D.C. Police Department said in a tweet Monday that the man has been identified and is not believed to be a gunman or otherwise involved in the shootings,
Witnesses described a gunman firing down on a cafeteria from an upper floor and a gunman firing at people in a hallway on another floor. It wasn't clear whether the witnesses were describing the same gunman.
About 3,000 people work at the Naval Sea Systems Command headquarters, which builds, buys and maintains the Navy's ships and submarines and combat systems.
Todd Brundidge said he and other co-workers encountered a gunman in a hallway on the third floor. The gunman was wearing all blue, he said.
"He just turned and started firing," Brundidge said.
Terrie Durham added, "He aimed high and missed. He said nothing. As soon as I realized he was shooting, we just said, 'Get out of the building.'"
Rick Mason said a gunman was shooting from a fourth-floor overlook in the hallway outside his office. He said the gunman was aiming down at people in the building's cafeteria. Mason said he could hear the shots but could not see a gunman.
Mason said there are multiple levels of security to reach his office. That "makes me think it might have been someone who works here," he said.
Patricia Ward said she was in the cafeteria.
"It was three gunshots straight in a row — pop, pop, pop. Three seconds later, it was pop, pop, pop, pop, pop, so it was like about a total of seven gunshots, and we just started running," Ward told reporters.
One person died at George Washington University Hospital of a single gunshot wound to the left temple, said Dr. Babak Sarani, director of trauma and acute care surgery.
Janis Orlowski, chief operating officer of Washington Hospital Center, told reporters the hospital was treating three gunshot victims in critical condition. One was a Washington police officer and two were civilian women.
Orlowski said the police officer had gunshot wounds to the legs. One woman had a gunshot wound to the shoulder, and the other had gunshot wounds to the head and hand.
Associated Press writers Lolita C. Baldor, Stacy A. Anderson and Ben Nuckols in Washington contributed to this report.


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UPDATE: Possible suspect in livestock shootings
According to a news release from the Orange County Sheriff's Office, investigators have a suspect in the livestock shootings that occurred in a private property area of Mansfield Ferry Road in Vidor. Fifteen cows and calves were found fatally shot on Monday, April 15, at approximately 8:50 a.m. by a concerned citizen traveling past the field where the cattle lay dead and dying, according to Sheriff Keith Merritt on the morning of the discovery.
Livestock/animal control officer Deputy Rocky Bridges said then that a necropsy would be performed on the deceased animals in an effort to find evidence against the person or persons responsible for the slaughter, the offender(s) facing felony charges for 15 counts of animal cruelty.
Caretakers of the deceased livestock were at the scene in the early afternoon of April 15, searching for clues as to who may have committed the livestock killings and waiting for a local veterinarian to arrive and examine the animals. Judy Williams, one of the caretakers at the property, said those slaughtered were more than just cattle to her; she had genuine affection for them.
"We nursed one of the calves from birth, bottle-feeding it," she said that morning, adding that she had no idea who would want to harm the cattle. "I tried nursing them (the dying cattle) back to life, but it didn't work this time."
Williams said in addition to the slaughtered cattle, two bulls were missing from the property. They are marked with the bar double-aught brand, a bar with two circles under it, and one is a registered Charolais.
"They were not among the dead," Williams said. "We can't find them on the property anywhere...They were either taken off the property or broke through the fence when they were frightened by the gunshots."
The bull were later discovered in hiding on the property, according to Williams.
Williams said she walked along the fence line of most of the property and found no bullet casings and no evidence the fence was down where the bulls might have crossed. She confirmed there are still cattle on the property and described some of them, particularly the females whose calves were shot, as "very traumatized" by the violent slaughter. She said neighbors with cattle have looked among their herds for the missing bulls to no avail. According to Williams, everyone in the neighborhood, especially livestock owners, are concerned about the shootings.
Deputy Bridges said Tuesday, April 16, the initial necropsy revealed the cows died of multiple gunshot wounds, but he was not able to release the caliber of the gun used in the incident. He said evidence is being examined at the crime lab, and several people are being interviewed in regard to the crime. A neighbor reportedly heard gunshots sometime during the night, and law enforcement officers are following up on leads.
"I just want us to find out who did it," Bridges said on April 16.
As of May 23, investigators hope they are one step closer by identifying a possible suspect. The case has been forwarded to the Orange County District Attorney's Office for review and disposition. The name of the suspect is not being released at this time as that person has not been officially charged with the crime.
So for now, the investigation continues. Anyone with information about the livestock shootings should contact the sheriff's office at (409) 883-2612.


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Welcome to WineInvestment.com
The team here at Cult Wines are delighted to welcome you to this unique website designed to provide clients and visitors with the opportunity to access our range of leading edge service solutions to the fine wine market.
We believe this site will become the focal for point for the fine wine investment market. As an investor you will benefit from our comprehensive, detailed and easy accessible content ensuring an unrivalled service dedicated to providing the best coverage for the investment market.


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NEW YORK -- In one of the more elaborate and unexpected spoofs of Donald Trump, Johnny Depp has joined the ranks of the combed-over, starring in a mock documentary released the morning after the GOP candidate's primary victory in New Hampshire.
The comedy website Funny or Die on Wednesday unveiled "Donald Trump's The Art of the Deal: The Movie," a 50-minute video styled as Trump's own self-made TV movie adaptation of his 1987 best-selling advice book.
The film, shot clandestinely, stars Depp as Trump in a startling transformation for even the actor known for outlandish metamorphoses, like the Mad Hatter and Whitey Bulger. After Owen Burke, Funny or Die's editor in chief, came up with the concept, the site's co-founder Adam McKay (and director of the Oscar-nominated "The Big Short") called Depp and ran the idea by him.
"I pitched it to Johnny right there," said Burke. "The fact that Johnny said yes, we were just so excited. We couldn't believe it."
Along with Depp's leading performance, the movie is narrated by Ron Howard (who claims the film was discovered after "the Cybill Shepherd blouse fire of 1989"), features a theme song from Kenny Loggins and includes a cast of Alfred Molina, Jack McBrayer, Patton Oswalt, Stephen Merchant, Henry Winkler and Andy Richter.
With '80 video graphics, "The Art of the Deal" is presented as written, directed and edited by Trump, himself - a relic of earlier brand-building propaganda by the businessman, long before his abrupt turn into politics.
"Successful people are always on the phone - even if there's no one on the other end," the fake Trump lectures a boy in one scene.
"We wanted to make it '80s cheesy, but we knew he would have the classiest of the '80s graphic packages," says Burke. "It couldn't look that good, but it couldn't look cheap."
Written by Joe Randazzo, the former editor of The Onion, and directed by "Drunk History" co-creator Jeremy Konner, the film, Burke says, is about Trump "as this strange product of American celebrity worship and entrepreneurship."
Depp, who filmed his scenes over four days in December, impressed the filmmakers with his dedication to the role and ability to improvise.
"If you watch his eyes, he does these little things," says Burke. "He's self-assured but there's also so much dark doubt underneath it all."
"The Art of the Deal: The Movie," was first planned in August, when many didn't expect Trump's ascendance to last into the primaries. Trump commandingly won the New Hampshire primary on Tuesday, with Ohio Gov. John Kasich a distant second.
"We were thinking: We've got to get this movie out before he goes away," says Burke. "And it doesn't seem like he's going away."


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SAN JUAN, Puerto Rico (AP) — Guards at the Guantanamo Bay prison used "non-lethal force" to quell a disturbance in a recreation yard, a military spokesman said Wednesday, declining to confirm a lawyer's account that a shot was fired and that one prisoner was injured.
The incident occurred Jan. 2, but only came to light this week after the attorney, Clive Stafford Smith, released a letter he sent to the commander of the prison on the U.S. base in Cuba requesting an investigation.
A spokesman for the prison, Navy Capt. Robert Durand, said the incident has already been reviewed and found to be in compliance with procedures. "It was a proper use of force."
The military says the disturbance was brief. Durand said a detainee attempted to climb a fence and a small crowd of detainees began throwing rocks at a guard tower. Guards then issued repeated warnings, before using "appropriate crowd dispersal measures," and the crowd immediately broke up. Medical personnel evaluated the men involved and determined that none needed treatment, he said.
Durand declined to reveal what measures were used to disperse the crowd or to say what methods guards have at their disposal.
In his letter to the commander, Smith gives a conflicting account from prisoners. He said a detainee was prevented from entering the recreation yard and was trying to get the attention of a guard, who then aimed a rifle at him.
"Other detainees saw this, and immediately responded, fearful that the guard would shoot their colleague," Smith wrote. "The guard thereupon swung his rifle around on them, and fired one round."
He said one prisoner was injured in the throat, but that it was unclear whether he was struck with some type of non-lethal projectile, such as a rubber bullet, or from ricochet.
Neither the military nor Smith identified the prisoner. The lawyer, however, said he was an Afghan whose name had been mentioned as a candidate for release as part of a possible peace deal between the United States and the Taliban.
The incident occurred in Camp 6, a section of Guantanamo generally reserved for prisoners who follow camp rules and where the men spend most of the day in a communal setting as opposed to confined to solid-walled cells. About 100 of the 166 prisoners at Guantanamo are in Camp 6.
Though conditions are better in Camp 6, detainees have been complaining through their lawyers that conditions have deteriorated in recent weeks and that guards have confiscated personal items such as religious CDs, blankets and legal mail. The military says there have been no major changes in conditions and denies reports from attorneys for the prisoners that there is a mass hunger strike in the camp.


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From: "Gilder Lehrman Center" <firstname.lastname@example.com> GLC 2014-15 Human Trafficking and Modern Day Slavery Fellowship The Gilder Lehrman Center for the Study of Slavery, Resistance, and Abolition (GLC), part of the MacMillan Center for International and Area Studies at Yale University, invites applications for a residential fellowship from scholars and public intellectuals to study the fundamental origins and circumstances surrounding debt bondage, forced labor, human trafficking, and other forms of modern day slavery. Traditional academics as well as writers/researchers without academic institutional affiliation are encouraged to apply. The Center is offering one fellowship in 2014-15. This is an interdisciplinary fellowship program, based in history and the social sciences, which aims to promote innovative research on the origins and conditions that lead to contemporary slavery. In recent years many NGOs and other activists have worked very hard to provide data, to engage in intervention, and to raise public and governmental awareness on this international problem. At the GLC and at Yale, and other cooperating institutions such as the National Underground Railroad Freedom Center in Cincinnati we believe the issues of modern slavery would benefit from a more robust research base rooted in, but not necessarily limited to, historical analysis and interpretation. In this aim and spirit we offer this annual fellowship. The Fellow will be expected to be in full-time residence during the academic year beginning September 1, 2014. An earned doctorate in a relevant field or alternatively equivalent qualifications for research and teaching are expected for the successful candidate. In addition to working on his/her own research project, the Fellow is expected to teach one course related to his/her research and hold related office hours for students, and offer one public lecture or conduct a workshop either at Yale or at the Freedom Center in Cincinnati. The Fellow is also expected to interact with students and faculty, contribute to the intellectual life of the Center, and participate in its collective activities and development. Ideally, the fellow will also complete a significant publication during his/her residency. Under the direction of Professor David W. Blight, the Center fosters an intellectual community at Yale through the interaction of students, faculty, and visiting scholars interested in the understanding of all aspects of the institution of slavery from the earliest times to the present. The Center organizes various activities, including lectures, speaker series, workshops, and conferences. For more information, visit www.yale.edu/glc. Resource Information The successful fellow will receive academic year compensation of $55,000 plus individual health insurance coverage. All Gilder Lehrman Center Fellows will have full access to the Yale University libraries and email. Normally, Fellows can expect shared office space, computer access and basic office supplies. Interested candidates, who have other sources of funding, may apply with a clear indication of their funding situation. All applicants should indicate clearly whether they are seeking full or partial funding. AA/EOE; applications from women and minorities are encouraged. Application Process Applicants should apply through Academic Jobs On-Line, https://academicjobsonline.org/ajo/jobs/3835, and must include the following: 1. Cover letter, including current e-mail address 2. Current curriculum vitae, including publications 3. A 1500-word description of the proposed research project. The description should include the background, nature, importance, specific objectives, and methodology of the proposed research project. 4. Two letters of recommendation. Referees should discuss the candidate's teaching ability as well as other points. Letters of reference can be uploaded directly by the referees through the online application site. 5. An official university transcript (graduate level, if applicable). 6. A summary of the proposed course (300-word max) Deadline for submission: March 1, 2014 For additional information e-mail email@example.com. Late or incomplete applications will NOT be accepted. Gilder Lehrman Center for the Study of Slavery, Resistance, and Abolition Yale University Website: www.yale.edu/glc firstname.lastname@example.com -- -- Patrick Cox H-NET Vice-President, Networks H-AMSTDY Managing Editor H-MATERIAL CULTURE Editor H-GRAD Advisor Board Member https://networks.h-net.org/users/patrick-cox-h-net-editor --
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themoonisdown wrote:We wanna know YOU here at LTR/LTT we think that's what makes us different. So introduce yo-self and let us know a little more about you... do you like hAHburgAHs? Do you prefer Kellan to Rob? Do you eat goldfish after a certain act (ahem...)? We wanna know!
I'll go first!
Hello my name is: Themoonisdown (Hello, Themoonisdown!) Most of you call me Moon or any variation there of... I'm one of your happy little bloggers who writes some of the goodies over at LTR/LTT! I enjoy long walks on the beach but as of now I can't decide whether I want to be walking with Rob or Jackson... oh who am I kidding. It'll always be Rob! Loves Sprinkles Cupcakes, wasting away the day at the record store, buying vinyl, going to concerts and shoes. Lots and lots of shoes...
Reply to this post and let us know about you!
unintendedchoice wrote:What a fun game!
Hi... I'm UnintendedChoice, and I'm a virgin (oh wait.. no I'm not... but this is my first "real" post on the forum. so yes I am.. Shh.. don't tell Rob.. or.. do you think he'd like that? Okay tell him)
My name isn't really UnintendedChoice, but all my friends call me that. And by "all my friends" I mean no one except for sometimes "themoonisdown' when we're being silly and referring to each other by our pretend names. No, I won't tell you my real name. Not because I don't love you, just mostly because I'm afraid of my grandmother finding out about this hobby of mine.
Okay 3 things about me: I love cats (REALLY love them), I love the internet (duh) and I have 3 younger sisters who are basically the most amazing things in my life cuz they're amazing and beautiful and I'm so lucky to have them.
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text: Our classic European designed pub handles evoke the traditions of tavern life in England and the Emerald Isles. Simple, yet versatile, these wood Tap Handles come in a variety of attention-grabbing colors, and can be customized with gold or silver ferrules and finials (included), and choice of shield style. Available in three sizes, the pub handle allows for consistent brand messaging across a number of applications.


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BOSTON (AP) — Funeral arrangements for the Boston Marathon bombing suspect killed in a shootout with police are being handled by a funeral home that has experience with Muslim services.
Peter Stefan, owner of Graham Putnam and Mahoney Funeral Parlors in Worcester (WUS'-tur) confirmed Friday he is handling funeral arrangements for Tamerlan Tsarnaev (TAM'-ehr-lun tsahr-NEYE'-ehv) but he could not confirm whether he has possession of the body.
Stefan says everybody deserves a dignified burial service no matter the circumstances of their death and he is prepared for protests. He says arrangements have yet to be worked out.
Several protesters showed up outside a North Attleborough funeral home Thursday night where Tsarnaev's body was taken following its release by the state medical examiner.
Timothy Nay of the Dyer-Lake Funeral Home says he is no longer in possession of the body.


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Mumbai: Prabhudheva and Remo D`Souza, who are die-hard Michael Jackson fans, will pay tribute to the late pop legend in the upcoming film `AnyBody Can Dance` (ABCD).
The film is being produced by UTV Motion Pictures and directed by Remo.
"Yes, it is true that we have thought about this. We want to execute it when we shoot our next song where Prabhu features with me," Remo, who will also feature in the song with Prabhudheva, said in a statement.
"Everyone knows how deeply I respect Michael Jackson and when I`m doing a film on dancing, it is impossible to not have something on him," he added.
Not only this, Prabhu will also be seen grooving with dancing diva Madhuri Dixit on a song in the film. This is the second time they have teamed up for a song after dancing on `Que Sera Sera` in 2000 release `Pukar`. It will be shot at multiple locations in Mumbai including Chhatrapati Shivaji Terminus and Dharavi.
`ABCD`, India`s first dance film in 3D, will also have choreographer Ganesh Acharya in the cast.
Lauren Gottlieb, winner of the popular international television talent show `So You Think You Can Dance`, has been roped in as the female lead.
It also stars the winners of Indian dance reality show `Dance India Dance` Salman Khan, Dharmesh, Prince, Mayuresh and Vrushali.


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|Black police officer discovers a cell of white supremacist vigilantes within his department.
|Directed by:
|Mario Van Peebles, Melvin Van Peebles
|Mario Van Peebles, Josh Brolin, Cynda Williams, J.T. Walsh, Stephen Lang, Sean McCann, Melvin Van Peebles, Zach Grenier, Bruce Smolanoff, William MacDonald, Peter Kosaka, Kendrick Davis, Brent Schaefer, Sandi Ross, Michael Tough


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A small arsenal of guns covered the deck of the Coast Guard Cutter Smilax this week
BEAUFORT | A small arsenal of guns covered the deck of the Coast Guard Cutter Smilax this week after a mission that seized a few pieces of history.
Five cannons were raised Monday from the Queen Anne's Revenge shipwreck site at Beaufort Inlet, the most recovered at one time from the wreck considered to be Blackbeard's flagship.
"Today is definitely a red-letter day: five guns coming off the site," said David Moore, who has been a member of the QAR team since recovery efforts began.
The five concretion-covered cast iron cannons averaged about 2,000 pounds each and are among the largest of the guns recovered from the shipwreck site. They fired six-pound cannons and were used in defense of the Queen Anne's Revenge, which sank after running aground nearly 300 years ago.
The QAR team of researchers has identified nearly 30 cannons at the site and the ship may have had as many as 40 heavy cannons on it when it sank.
With the five raised Monday, 22 cannons have been recovered from the site.
The recovery Monday was the last opportunity for bringing up the artifacts with this week's close of the 2013 fall dive expedition at the shipwreck site. For the heavy lifting, the crew of the Smilax stepped in to raise each cannon out of the water and onto its deck, where they were readied for transport to the QAR conservation lab in Greenville.
The Fort Macon-based Smilax is the oldest ship in Coast Guard service and holds the title of Queen of the Fleet.
Smilax Commanding Officer Scott McAloon said Monday's mission was a unique opportunity to see history recovered from the ocean and for the Coast Guard to partner with other agencies to accomplish the project.
"It's a great day for North Carolina and a great day for the Coast Guard to have this opportunity," he said.
For Kimberly Kenyon, who began working at the QAR lab as a conservator earlier this year, it was her first trip to see cannons raised from the site.
"It's exciting to be dealing with something so historic and significant. It's a big day for North Carolina," she said.
In addition to the cannons raised, two large concretions were raised Monday that include cask hoops and other artifacts.
Earlier in the fall dive, two smaller cannons were raised. Kenyon said several timbers, including a 7-foot piece of the ship, were also recovered.
As the fall dive came to a close, the QAR team remained optimistic that full recovery will be possible next year.
"We're going to continue excavating the site and have it completed by 2014," Project Director Billy Ray Morris said.
An extensive Queen Anne's Revenge exhibit can be seen at the N.C. Maritime Museum in Beaufort, the official repository for artifacts from the QAR site.
Jannette Pippin writes for the Daily News in Jacksonville.


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; Moraxella catarrhalis - pathogen or commensal? Adv Exp Med Biol. 2011697:107-16.
; Prevalence and resistance pattern of Moraxella catarrhalis in community-acquired lower respiratory tract infections. Infect Drug Resist. 2015 Jul 318:263-7. doi: 10.2147/IDR.S84209. eCollection 2015.
; Vaccine targets against Moraxella catarrhalis. Expert Opin Ther Targets. 2015 Aug 23:1-15.
; Characterization of the molecular interplay between Moraxella catarrhalis and human respiratory tract epithelial cells. PLoS One. 2013 Aug 68(8):e72193. doi: 10.1371/journal.pone.0072193. Print 2013.
; Population density profiles of nasopharyngeal carriage of five bacterial species in pre-school children measured using quantitative PCR offer potential insights into the dynamics of transmission. Hum Vaccin Immunother. 2015 Sep 14:0.
; Evaluation of swabbing methods for estimating the prevalence of bacterial carriage in the upper respiratory tract: a cross sectional study. BMJ Open. 2014 Oct 304(10):e005341. doi: 10.1136/bmjopen-2014-005341.
; Bacterial pathogens in the nasopharynx, nasal cavity, and osteomeatal complex during wellness and viral infection. Am J Rhinol Allergy. 2013 Jan27(1):39-42. doi: 10.2500/ajra.2013.27.3835.
; Moraxella catarrhalis: from emerging to established pathogen. Clin Microbiol Rev. 2002 Jan15(1):125-44.
; Molecular mechanisms of moraxella catarrhalis-induced otitis media. Curr Allergy Asthma Rep. 2013 Oct13(5):512-7. doi: 10.1007/s11882-013-0374-8.
; Genetic analysis of a pediatric clinical isolate of Moraxella catarrhalis with resistance to macrolides and quinolones. J Infect Chemother. 2015 Apr21(4):308-11. doi: 10.1016/j.jiac.2014.11.002. Epub 2014 Nov 14.
; Ceftaroline in the management of complicated skin and soft tissue infections and community acquired pneumonia. Ther Clin Risk Manag. 2015 Apr 711:565-79. doi: 10.2147/TCRM.S75412. eCollection 2015.
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Stay tuned for more on the Yuneec Typhoon H520 .
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Hey guys, this is Jonathan Feist. As a little history, I have been an enthusiast of flight for many years. My youthful enthusiasm matured into something real when I began studying government issued Aviation Training material in 2007, eager to get my private pilot's license, or better yet, to become a helicopter pilot. I flew my first real life airplane in 2009, the little Cessna you see above. (Thank you again, Ethan!) Sadly, that was also my last time at the helm of a passenger aircraft, for now.
Effect of 50 mM coaggregation inhibitors on autoaggregation. cells were incubated in SDM containing 25% saliva and several different coaggregation inhibitors. The samples from left to right are as follows: water, lactose, galactose, arginine, and lysine. The results presented here are the averages of three independent samples. This experiment was performed two times, with similar results each time.
Effect of lysine concentration on autoaggregation. cells were incubated in SDM containing a range of lysine concentrations and measured for OD every 10 min. The lysine concentrations are as follows: squares, 0 mM; triangles, 6.25 mM; asterisks, 12.5 mM; circles, 25 mM; and crosses, 50 mM. The results presented here are the averages of three independent samples. This experiment was performed three times, with similar results each time.
Transcriptome analysis of planktonic versus aggregated cells. Given the strong propensity for 25586 to aggregate under the conditions of our assay, our next goal was to determine whether aggregation would elicit any gene responses from the cells. For this purpose, we decided to take a microarray approach to measure the effect of intraspecies cell aggregation upon the transcriptome. Since saliva could induce aggregation and lysine could inhibit it, we could take two potential microarray approaches (Fig. 4 ). We could either measure the transcriptome of cells incubated in (condition 1) SDM plus saliva (aggregation) versus SDM (planktonic) or (condition 2) SDM plus saliva (aggregation) versus SDM plus saliva plus lysine (planktonic). However, both approaches had the potential drawback of measuring gene responses to aggregation, as well as differences in medium composition (i.e., saliva for the first approach or lysine in the second approach). In order to circumvent this limitation, we decided to assay both conditions (condition 1 [+/− saliva] and condition 2 [saliva +/− lysine]). We reasoned that if aggregation elicited a specific and reproducible genetic response, then both microarray approaches should yield a shared geneset, since aggregation would occur in both approaches (Fig. 5 ). In contrast, responsive genes that were uniquely affected in either experiment were most likely attributable to factors other than aggregation, such as differences in medium composition (Fig. 4 ). Thus, we compared the results from the two microarray experiments using a cutoff value of a ≥2-fold change and were able to identify 96 genes with similar responses in both experiments. In microarray condition 1, this left 51 gene responses that were unlike those of microarray condition 2 and 73 responses in condition 2 that were dissimilar to microarray condition 1 (Fig. 4 ). From these results, we concluded that the 96 genes similarly affected in both experiments were most likely to be specifically responsive to aggregation, whereas the 51 and 73 unique gene responses in microarray conditions 1 and 2 were probably due to other factors. Consequently, we focused our analysis on the shared geneset of 96 genes. From this group of genes, 54 exhibited changes of ≥3-fold. Interestingly, the vast majority of the 96 aggregation-specific genes were upregulated, while only four genes were downregulated. This result is consistent with the activation of a genetic program. Although we did not detect changes in the transcription of any putative sigma factors, we did identify three putative transcription regulators that were induced, FN0795, FN1439, and FN1803, which may account for some of the observed gene expression changes in the list (Table 2 ). FN1803 was particularly interesting because its microarray signal intensity in the dispersed samples was quite weak, much lower than FN0795 and approximately half that of FN1439 (see Table S1 in the supplemental material). FN1803 also exhibited the greatest increase in expression due to aggregation (three- to fivefold).
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16 Oct
Thirteen players have been named as part of the Ireland Women's 7s squad for the opening round of the 2018-19 HSBC World Rugby Women's Sevens Series in Glendale, Colorado this weekend.
Our two previous Plans, covering the last eight years, were instrumental in driving Irish rugby to the current levels
across all strands of the game.
At the time of printing (November 2013) there remains a lot of debate about the future of one of our premier competitions the Heineken Cup. However, while the negotiations on the future of this great competition are on-going it is incumbent on us to proceed with our plans for the future of our game.
The outcome of the on-going discussions may result in an amendment to this plan, but the overarching ambition, goals and targets for the development of Irish rugby must remain.
As the Governing Body for rugby across the island of Ireland and following almost two years of research and consultation with stakeholders, it is our collective resolve that this next stage in our vision for Irish rugby should be titled:
"From Grassroots to International Success; One Island, One Passion, One Goal''.
Pat Fitzgerald, IRFU President Finbarr Crowley, Chairman
The Strategic Plan This document is a concise summary of the strategic goals for Irish Rugby over the next 4 years. Further information
providing more background on all aspects of this plan can be found in the below documents and links:
Club Sustainability Report April 2013
IRFU Strategic Plan 2008 - 2012 'Building On Solid Foundations'
Strategic Review Process Key Dates


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Cabaret, the musical based on a book written by Christopher Isherwood, was first staged on Broadway in 1966. Rufus Norris' 2006 revival stars Pop Idol winner WillYoung alongside ex-EastEnders actress Michelle Ryan at the Savoy Theatre. Read Charles Spencer's review here.
Above: Will Young as Emcee and cast in the revival of Rufus Norris' production of Cabaret
For more information see the Savoy theatre websitePicture: Alastair Muir


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The mission of the Division of Student Affairs is to assist students in achieving their academic goals and enhancing their personal, intellectual and social development through the provision of a broad range of programs and services. As "partners in learning," the division strives to enhance and support the academic mission of the university, to assure the rights of the individual, to seek solutions to persistent issues and problems and to encourage independent thought and action. The division works to contribute to the development and maintenance of a healthy, safe and orderly campus environment that is responsive to the needs of a diverse student body and conducive to the development of leadership, citizenship and collegiality of students.
The major responsibility of the Division of Student Affairs is to maintain a comprehensive education and student support service program to meet the needs of students. Toward these ends, the division provides oversight and direction for more than 35 university programs and service areas that support CSULB students outside the classroom.
In concert with the university's strategic priorities, the Division of Student Affairs at California State University, Long Beach will be widely recognized for its high quality of services, activities and programs for students.
We will enhance our partnerships with faculty, staff, student and community groups so that we may serve as primary advocates to meet the needs of our diverse student population.
We will embrace a culture of evidence that strives for continued quality improvement in our programs and services.
We will invest in our human and technological resources so that we may optimally respond in a dynamic environment.
The division is committed to making a positive contribution to the greater society by developing responsible citizens, with highly valued degrees, for the 21st century.
Engage students through activities, programs and support services that enhance student achievement, satisfaction and overall wellness. Prepare students for a highly valued degree, graduate and professional studies, employment, responsible citizenship and lifelong learning.
Promote and strengthen mental health and physical health for all members of the campus community through programs of prevention, awareness and response.
Promote collaborative efforts with other university divisions and the community to provide comprehensive, high quality services, programs and activities for students. Develop and strengthen relationships with students, their parents, faculty, staff, alumni and the community.
Enhance the university's commitment to a diverse student body by facilitating access to educational programs and student academic success.
Provide and assess programs, services and activities that promote a campus climate that is inclusive, civil, ethical and safe.
Maximize use of allocated resources by practicing prudent stewardship and by actively seeking external opportunities to enhance resources for division programs, services and activities.
Enhance the campus environment through the planning of new facilities, and capital and minor improvements.
Promote the division's culture of evidence and assessment practices by measuring student learning outcomes, conducting self-studies of programs and activities, and using findings to improve our services.


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INDIANAPOLIS—Unsupervised teenagers with nothing to do and easy access to guns are a recipe for trouble, experts said Sunday after a late-night shooting that wounded five youths in downtown Indianapolis.
Indianapolis Police Chief Paul Ciesielski said he has had more officers downtown since three shootings injured 10 young people during the Indiana Black Expo in the summer of 2010. A community task force found that teenagers were being dropped off in the area and left unattended.
But Ciesielski said there's only so much officers can do.
"Parents just need to be more responsible and not use the downtown as a baby sitter," he said after the latest shootings, which happened as crowds reveled along a downtown canal that had been dyed green for St. Patrick's Day.
"Two of the victims were 14 years old," Ciesielski said in an email. "Why were they there at 10 p.m. without parental supervision? Who are they hanging with while downtown?"
None of the victims, who ranged in age from 14 to 17, had life-threatening injuries, police said. Police searched a residence on the city's northside and questioned several people Sunday, but there were no arrests, Sgt. Linda Jackson said.
Jackson said detectives believe the shooting stemmed from a "lingering argument" between two groups of people.
The chief said police had extra officers downtown Saturday night both in and out of uniform, though he declined to say how many. He said the department routinely assigns plainclothes officers trained to deal with youth to the Circle Centre Mall, a popular downtown gathering place for teens.
Bill Glick, director of the Indiana Juvenile Justice Task Force, said another piece of the problem was the availability of guns. Teens can get hold of guns at home or buy them on the street, he said.
"Our kids tell us it's no problem getting a gun," he said. "I ask kids if I drop you off in downtown Indianapolis, how long would it take to find someone to help you get a gun? They say probably a couple of hours."
Glick added that many teens seem to be desensitized to violence.
"They somehow seem to be inured to the fact that if you shoot a gun it's not like a video game, someone really gets hurt," he said.
Police said three teens shot Saturday were taken to nearby Riley Hospital for Children. They were a 14-year-old boy shot in the chest, a 14-year-old boy with a gunshot wound to the face and a 16-year-old girl shot in the leg.
Jackson said the boy who was shot in the chest and the girl had been upgraded from critical to serious condition. The other boy was released earlier Sunday, Jackson said.
The two other shooting victims, both 17-year-old boys, were taken to another hospital, one with a gunshot wound to the back and the other shot in the leg, according to the police statement. They had both been released by early Sunday, police said.


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Definitions of stay
n. - A large, strong rope, employed to support a mast, by being extended from the head of one mast down to some other, or to some part of the vessel. Those which lead forward are called fore-and-aft stays; those which lead to the vessel's side are called backstays. See Illust. of Ship. 2
v. i. - To stop from motion or falling; to prop; to fix firmly; to hold up; to support. 2
v. i. - To support from sinking; to sustain with strength; to satisfy in part or for the time. 2
v. i. - To bear up under; to endure; to support; to resist successfully. 2
v. i. - To hold from proceeding; to withhold; to restrain; to stop; to hold. 2
v. i. - To hinde/; to delay; to detain; to keep back. 2
v. i. - To remain for the purpose of; to wait for. 2
v. i. - To cause to cease; to put an end to. 2
v. i. - To fasten or secure with stays; as, to stay a flat sheet in a steam boiler. 2
v. i. - To tack, as a vessel, so that the other side of the vessel shall be presented to the wind. 2
v. i. - To remain; to continue in a place; to abide fixed for a space of time; to stop; to stand still. 2
v. i. - To continue in a state. 2
v. i. - To wait; to attend; to forbear to act. 2
v. i. - To dwell; to tarry; to linger. 2
v. i. - To rest; to depend; to rely; to stand; to insist. 2
v. i. - To come to an end; to cease; as, that day the storm stayed. 2
v. i. - To hold out in a race or other contest; as, a horse stays well. 2
v. i. - To change tack; as a ship. 2
n. - That which serves as a prop; a support. 2
n. - A corset stiffened with whalebone or other material, worn by women, and rarely by men. 2
n. - Continuance in a place; abode for a space of time; sojourn; as, you make a short stay in this city. 2
n. - Cessation of motion or progression; stand; stop. 2
n. - Hindrance; let; check. 2
n. - Restraint of passion; moderation; caution; steadiness; sobriety. 2
n. - Strictly, a part in tension to hold the parts together, or stiffen them. 2
The word "stay" uses 4 letters: A S T Y.
No direct anagrams for stay found in this word list.
Words formed by adding one letter before or after stay (in bold), or to asty in any order:
a - satay e - yeast g - stagy h - hasty k - kyats l - salty slaty m - mayst n - antsy nasty tansy p - pasty patsy r - artsy satyr stray trays s - sayst stays t - tasty v - vasty
Shorter words found within stay:
as at ay ays sat say sty ta tas ya
List shorter words within stay, sorted by length
Words formed from any letters in stay, plus an optional blank or existing letter
List all words starting with stay, words containing stay or words ending with stay
All words formed from stay by changing one letter
Other words with the same letter pairs: st ta ay
Browse words starting with stay by next letter
Previous word in list: staw
Next word in list: stayed
Some random words: pneuma wud emic oubliette ridley niblick hwan
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W.Va.'s Manchin: Time to rethink gun legislation
- Article by: PAM RAMSEY and MICHELE SALCEDO
- Associated Press
- December 17, 2012 - 3:45 PM
CHARLESTON, W.Va. - Sen. Joe Manchin, an avid hunter and lifelong member of the National Rifle Association, says it's time for all sides in the gun policy debate to move beyond the political rhetoric and begin an honest discussion about reasonable restrictions on guns.
The school shooting in Connecticut that killed 20 children has changed the dialogue, Manchin said.
"I'm not afraid to say, `Let's talk about that,'" Manchin told reporters during a conference call Monday. "I'm not afraid of the political ramifications."
"You have people who want to use scare tactics and extremes and try to drive a wedge when we're trying to have a dialogue," he said. "Don't you think we should at least sit down and talk about it?"
The comments by the West Virginia Democrat came on the day of the first funerals for the Sandy Hook Elementary School students killed Friday.
The massacre renewed calls from some Democrats for a ban on military-style assault weapons and a look at how the nation deals with individuals suffering from serious mental illness.
Manchin said school safety, movies and videogames that glorify violence should also be part of the discussion.
"This needs to have an adult conversation about the society we have become and the direction we are going," he said.
President Barack Obama traveled to Newtown, Conn., Sunday night to console the grieving families, the fourth such trip he's had to make during his presidency. He vowed to use "whatever power this office holds" to safeguard the nation's children, raising the prospect he will pursue policy changes to stem gun violence.
Gun control was a hot topic in the early 1990s, when Congress enacted a 10-year ban on assault weapons. But since that ban expired in 2004, few Americans have wanted stricter laws and politicians say they don't want to become targets of a powerful gun rights lobby.
"We can't be afraid to talk about it," Manchin said. "I'm not supporting a thing except open dialogue."
Manchin, who had been hunting with his family over the weekend, also said a 2010 campaign ad that showed him firing a hunting rifle at a paper target labeled "Cap and Trade Bill" did not glorify firearms.
"What we did at that time and the way we used it was in the most responsible manner. I'm a proud gun owner and I'm a responsible user and I don't think that glorified anything. It was not intended for that," he said.
Manchin is the most prominent gun rights advocate to speak publicly in the wake of the shooting.
Chris Feldhaus, a 31-year-old Republican from Charleston, W.Va., said he voted for Manchin in November but believed his latest remarks were an effort to win more support.
"I like what he does, but lately it seems like he's more of a TV guy wanting to be on TV more so than worrying about the issues," Feldhaus said.
Terri Roush, another Manchin supporter from Nitro, W.Va., said even if he was just trying to be in the spotlight, the issue deserved to be in the spotlight.
"So if he's the voice to do it, then by all means. I think he's somebody in West Virginia that people respect, people admire. I think it's something that needs to be brought to everyone's attention," she said.
Salcedo contributed from Washington. Associated Press writer John Raby in Charleston also contributed to this report.
© 2018 Star Tribune