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Frame Capture and Analysis Tools Review
Over the past years, evaluations of video card performance have centered around actual game play or the use of time demos. The premise is to measure how a particular video card plays through a selected game sequence, determining the performance results measured either by an in-game frame rate capture or the use of FRAPS, a popular frame rate measuring tool. The problem is that many times the actual frame rates presented just do not match up with the gaming experience reported by the masses or for that matter us as editors, especially when it comes to multiple GPU configurations. Lately there has been a tremendous amount of buzz around looking deeper into this phenomena by again using FRAPS to measure in conjunction with the reported frames per second; the length of time needed to generate each frame sent to the display.
However, you are still using a software tool that measures the FPS data output from the game engine to the DirectX layer, giving you a false sense of what is going on, which we will explain later. Measuring what actually gets to the viewer is going to give a better representation of the displayed FPS instead of taking the reported software value as the truth, especially when your lying eyes tell you so much different. It's not an entirely new thought stream but is now getting traction as a way of determining the real performance for the end user.
Recently I was introduced to a set of hardware and software tools that NVIDIA has developed and have been using in-house for a little over two years now to improve gaming performance for the end user. Up front the tools have been provided by NVIDIA with the look going forward that these tools will be adopted and expanded upon by the open source community to really dig a bit deeper into what drives gaming performance metrics. NVIDIA calls this tool FCAT, or Frame Capture Analysis Tool. Let's start with a look at the hardware requirements for capturing the data needed for the analysis.
Why do we need to look at a hardware-based capture solution when we have software solutions to do this for us? Software solutions are counting frames that are generated by the game engine rather than what actually gets delivered to the end user's display or monitor. To measure the data sent out of the DVI port requires a set of hardware tools that can capture and store the data. What we have is a multi-part solution that includes a specially built capture system, preferably Intel Z77-based; a gaming system that has no special requirements. The capture system needs to be configured with a three to four disk RAID 0 storage drive that can handle the massive data stream delivered by the capture card. A configuration setup on the Intel controller is preferred to handle data rates of up to 650MB/sec when capturing outputs up to 2560x1440. Above that the capture card cannot handle the throughput. PCIe-based disk drive is another option to handle the data. At the heart of the capture system is the DataPath Limited VisionDVI-DL capture card that captures the full resolution data at 60Hz. Splitting the display signal to feed the DataPath Limited VisionDVI-DL capture card is the job of a Gefen DVI DL Splitter that sends the display signal to the display and the capture card.
Closer Look:
Software: The software portion of the FCAT toolbox includes proprietary and programs readily available for the end user.
- Overlay: DXFrameOverlay.dll + Enable Overlay.exe Overlays a fixed color sequence over the game while it's running
- Extractor: Extractor.exe Output = CSV of overlay colors and scanlines
- Analysis Tools: run_doall.bat, run_nv.bat, run_amd.bat These are batch files that expedite the use of the PERL script files below.
- fcat.pl: PERL script that combines bars and identifies runts and drops , Output = CSV of HW frametimes (similar to Fraps), and CSV of Original FPS, New FPS, Runts, drops
- gen_percentiles.pl PERL script that generates the 95 and 99th frametime percentile calculations.
- pivot.pl PERL script that generates a summary CSV file (good for a pivot table).
- doall.pl PERL helper script to generate a big batch file.
In addition to the batch files and perl scripts we will be using Virtual Dub as the capture medium and utility used to play back the recorded benchmark runs to easily identify both runt and dropped frames. Datapath's Vision software is used to to verify the display output is what is being passed through to the capture card. Extractor is used to analyze the overlay data, which is output to a .CSV file for further analysis and incorporation into the output charts and graphs. Overlay is the software that provides the visual indicator for each frame during the benchmark sequence again making it easy to identify runt and dropped frames.
So why go through all the trouble of setting up this kind of test regimen and investing in the hardware and software to visualize the actual performance into such low level detail? It's about digging deeper into the root causes for the performance issues driving gamers to write tomes on the subjects in forums across the Web. Especially when confronted with the stuttering and unrealistic FPS numbers that just do not add up to the game play experience. In no way is this article going to be as comprehensive as I would like but it gives a good start to how and why we will begin incorporating these metrics into our upcoming video card reviews.


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Heather Spiker-MacPherson, 32, has always dreamed of being a chef.
On Friday, the culinary student at Stratford University and staff sergeant in the U.S. Army Reserves will be able to put her skills to the test at a "Top-Chef"-style competition at Baltimore Green Works' EcoBall.
The annual EcoBall, held at the Frederick Douglass-Isaac Myers Maritime Park and Museum, will feature live music, food and drinks, as well as the cooking competition featuring Stratford University students (for more information, go to baltimoregreenworks.com/ecoball). The event will help Baltimore Green Works fund its Sustainability Speaker Series and other eco-friendly events.
Spiker-MacPherson, who is from Ligonier, Pa., and now lives in Pasadena, has never competed in something like this before, but said she is excited to see what she and the others can do.
"Plus, I am very competitive," she said.
Spiker-MacPherson would eventually like to be a personal chef, but for now she took the time to talk to us about, among other things, her past job at Cracker Barrel and her worst cooking experience.
Worst pet peeve? Lack of respect. We should respect each other more!
What song are you hating/loving right now? I'm loving "Seize the Day" by Avenged Sevenfold and I cannot stand "Gangnam Style." It's everywhere!!
Last concert/gig you went to? Volbeat at Rams Head.
Your worst habit? Smoking. I am a workout fanatic but can't stop smoking.
Worst or most embarrassing cooking experience? When I worked at Cracker Barrel and my dumplings came out in one mass instead of separating.
Guilty pleasure food? I love cheesecake. I could eat it all the time, but it has to be New York cheesecake. I LOVE IT!!!!!!!!
Trend that has exceeded its natural lifespan? YOLO. It took me forever to figure out what it meant.
Last movie you liked/disliked? I recently watched? "Hotel Transylvania." It was pretty funny.
TV shows you can't get enough of? "The Walking Dead," "Duck Dynasty" and "Chopped."
Last great meal you had? Fogo de Chao was so yummo!!!
Favorite dish to make? Sauerbraten and spaetzle.
Favorite and most loathed fashion statements? I don't really follow fashion. I kind of have my own style.
Favorite place to get a drink in Baltimore? I don't drink so unfortunately I wouldn't know.
Favorite celebrity chef? Gordon Ramsey.
Best advice you ever got? Treat others as you want to be treated.
Favorite thing about Baltimore? The crabs and the Inner Harbor.

subset: commoncrawl


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Players assume the square-jawed role of Cole Justice, an ex government secret service agent, trained mercenary and all-round tough guy, recruited by 'the agency' for one final assignment. According to intelligence reports, a rogue government agency known as 'Hydra' has been developing weapons of mass destruction to sell to worldwide terrorist organisations. Hydra has been long suspected of funding its activities through unlawful means, including the trafficking of arms and drugs
The government no longer has control over this rogue agency and it has quickly become an embarrassment in need of urgent elimination
Developed by award-winning game studios, Kuju, Conspiracy: Weapons of Mass Destruction is propelled by the powerful Fire Warrior engine and takes first person shooting to a whole new altitude. Across five sprawling levels, gameplay spans from secret bases in Aztec ruins to military training camps in the Arctic Circle.
As a trained mercenary, Cole's weaponry consists of pistols, assault rifles, sub machine guns, sniper rifles, grenade launchers and rocket launchers weapons.
Remember. Believe nothing... Trust no-one...
Conspiracy: Weapons of Mass Destruction is being developed by Kuju and will be published by Oxygen Interactive in March 2005 for PS2, Xbox and PC, price to be confirmed.
More articles about Conspiracy: Weapons of Mass Destruction


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Cosmopolitan Las Vegas to open new theater
LAS VEGAS (AP) — The Las Vegas Strip's newest concert space will open its doors just before the new year with a performance by pop star Bruno Mars
Mars will play shows on Dec. 29 and 31 at a new Eastern European glass factory-themed venue at the Cosmopolitan Las Vegas, and then return six more times during 2014, casino management announced on Tuesday.
The 3,000-capacity theater, called the Chelsea, features glass chandeliers, brick walls, a grand staircase, high ceilings and a vintage wooden bar.
The Cosmopolitan is touting the space as an "avant garde" venue where fans can get an up-close look at stars who usually play arenas. By contrast, the Coliseum at Caesars Palace, where singer Celine Dion performed her long-running residency, seats 4,000.
CEO John Unwin told The Associated Press earlier in the year that the space would be an antidote to vanilla venues along the Strip. Asked about the project's price tag, Cosmopolitan spokeswoman Alyssa Anderson said the company does not disclose capital costs.
In a statement, Mars warned Vegas to get ready for him and the Hooligans, his eight-piece backup band.
The 27-year-old songwriter and producer turned frontman will lead his audience in the New Year's countdown, taking on a role often performed up and down the Strip by Sin City regulars like Kim Kardashian and Nicki Minaj. Tickets start at $150.
Mars was picked to perform at the Superbowl halftime show in February. His debut album, "Doo-Wops & Hooligans," was released in 2010.
The last major Las Vegas resort approved before the Great Recession, the $3.9 billion Cosmopolitan was built by a German investment bank after its original developer defaulted.
It has recovered from the brink of bankruptcy and has branded itself as a "decidedly different" kind of casino, eschewing the kitschy themes common among its competitors, and catering to a more urbane kind of gambler and club-goer.
The 50,000 square-foot space that will become the industrial-chic Chelsea has sat empty since the Cosmopolitan opened in 2010. In preparation for its opening, hotel-casino's existing concert venue, previously called the Chelsea Ballroom, has been renamed the Belmont.
This being Vegas, the casino is marketing the Mars concerts as part of a package that includes a two nights in the hotel and "VIP check in." The package starts at $1,800.
Hannah Dreier can be reached at http://twitter.com/hannahdreier.


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Jim Christian Facing Old Program, Friends At Kent< < Back to
Jim Christian saw this day coming.
Since the moment he was named head coach of the Ohio men's basketball team, Christian knew he'd find himself walking the sidelines where his coaching career began in Kent, Oh.
From 2002-2008, Christian made a name for himself in Kent State and Mid-American Conference basketball history. He was the 2006 and 2008 MAC Coach of the Year, won 138 games and qualified for the NCAA Tournament twice in his tenure.
His familiarity with the Golden Flashes program is unchallenged when compared with any other coach in Bobcat history. After all, he helped build the Flashes program that it is today.
Not only will Christian be going up against his former program, but he'll also be calling plays from the opposite sideline of former assistants and players, now coaches at the university.
In fact, his former assistant and best man of his wedding Rob Senderoff is now in his second year as the Golden Flashes' head coach. Having to coach against his friends and former colleagues will not be a happy reunion for Christian.
"It's hard, man. It's hard," Christian said. "Again, these guys don't care and their players don't care, so we've got to go play. We're going to do the best we can to prepare our team.
"Kent was a special place to me, but (Ohio) is a special place, too. We're just going to do the best we can and get ready to go."
To say, "Kent was a special place to (Christian)" is an understatement on his part. When he returns to the Memorial Athletic and Convocation Center (MAC Center) on Saturday, he'll be standing in the place where he won 61 games as head coach. When told he won that many games in the arena, Christian was even shocked a bit.
But a look over at the Kent State coaches would give Christian an understanding of why he won so many games in the MAC Center. There are three outstanding assistants who once played under Christian while at Kent State.
One of the three knows his system inside-and-out. Eric Haut played for Christian at Kent State for a short period of time before becoming an assistant from 2006-08. When Christian took the coaching position at Texas Christian, Haut followed him there for three years. The two went their separate ways when they returned to Ohio, Christian going to Ohio University and Haut returning to his alma mater.
Two more of Senderoff's assistants are DeAndre Haynes and Mike McKee, who were both a part of an NCAA Tournament team under Christian. Haynes is regarded as one of the best players to ever play under the Ohio head coach, as well as in Kent State history. He was named 2006 MAC Player of the Year and Honorable Mention All-America.
As Christian stated, he's "very familiar" with what Kent State's coaching staff has prepared for Saturday's game. Then again, they know his coaching style as well.
"I think a lot of the stuff we do here, they're doing over there. I think a lot of the stuff we ran (at Kent State) they're still running," Christian said. "I mean you work with somebody for that many years. We helped each other put stuff together and built the program. It's a lot of similarities."
But does that affect the way Christian or Senderoff coach this huge MAC East Division game? With both coaches knowing each other's systems so well, how does that affect their preparation?
"In this day and age, there's so much film on everybody, there's no surprises. We pretty much know, for the most part, what everybody's trying to do," Christian explained. "There's some wrinkles here and there, but it's like everybody else, for the most part, you understand what they're trying to do, and they understand what you're trying to do, so these games all become execution by games.
"Who can execute better, who's coming with the right mentality, who can play through the team, who can play through the scratches, that's what it comes down to."
In the Convocation Center, Christian is used to a big student section and fans to pack the house when a big opponent comes into town. The MAC Center, as Christian says, is very similar.
A tightly packed gym that was built in 1952, the arena holds 6,327 fans and when a divisional opponent comes into Kent, especially the Bobcats who have yet to lose a conference game, every seat's expected to be filled.
"(The MAC Center's) not as big," Christian said. "It's half the size of the Convo, so the acoustics are a little louder and they understand. I mean shoot, they're used to winning at home, so they understand the importance of how important it is to win these types of in-division games at home. You have to give yourself a chance."
In terms of atmosphere, Christian has a difficult time comparing any school to Ohio.
"I don't think there's 10 better student sections in the country than (Ohio). I mean that sincerely. Our student section is off the charts," Christian said. "(The MAC Center's) just like here. It gets incredibly loud. There's a lot of energy."
Christian is prepared for the changes to the program he once built when he enters the arena this weekend. He acknowledges that several things have changed since his coaching days.
"These (Kent State) players don't know me," Christian said. "None of the students there know me. Fans maybe, but that's irrelevant when the ball goes up."
That's ultimately how Christian coaches. When the ballgame begins, every single outside matter is lost. The game becomes the number one priority.
So when he looks out onto the court Saturday, he won't be giving directions to Haut, Haynes or McKee bringing the ball up the floor in a gold and blue jersey. Those days are long gone.
He'll know Senderoff's coaching style and what he will be planning in his huddles during timeouts, just as all of Christian's former players will know exactly what play Christian will be drawing up in familiar situations. In the end, it comes down to the players on the court and which ones can execute the coaches' plays to perfection.
With an All-MAC point guard in D.J. Cooper and a team undefeated in the conference this season, it's enough to make a coach feel right at home.
But Christian isn't planning a long stay. All he cares about now is getting out of Kent with that 62nd win in the MAC Center.


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> Have you been able to get the GO-32 > 145.930 APRS position uplink working? Yes, works perfectly. > What would be the setup for a non_D700. That channel requires a Mic-E formatted packet. Which is not human readable and is not trivial to type. Much easier to simply operate normal APRS position reporting on 145.85. Anyone with a 9600 baud TNC can manually communicate with anyone else and all APRS operators as follows. The simplest manually typed APRS compatible packet is a GRID SQUARE format. 1) Set UNPROTO APRS VIA 4XTECH 2) Set TNC to CONVERSE 3) Type this or any similar line: [FM19] bob here calling CQ GO32. If the packet begins with the 4 digit grid square exactly as shown, then it is a proper APRSformat and all APRS radios will show you on the map. Anything can be on the same line after the [GG##] format. Or you can be more specific with a [GG##gg] ... Format. Once your position is successful, you don't need to keep sending it. You can send simple STATUS packets by only typing a line starting with a ">"... So this line: >Hi everyone. Bob here with 50W into my mobile whip. And all APRS stations will see: STATUS: Hi everyone. Bob here with 50W into my mobile whip. So anyone with a 9600 baud TNC can play. Just start each line with a GRID SQUARE in brackets if you want to send a position report, or start it with ">" to send a one line status. You will then also poentially show up on FINDU.COM under your call if ther e is an Igate capturing the downlink. Just go to http://map.findu.com/URCALL Where you type in URCALL Bob, WB4APR and transmit your position there I seem to have a hard time getting > my position > data starting with 1 to 7 using UISS on the PC. > > Text messaging on 145.850 through GO-32 is working beautiful. > Thanks to all > the folks that made it work. I hope I have someone to chat > with on the next > pass (yes, non-interfering and within reason). Never had a > "live" digital > QSO on GO-32. > > 73, Stefan > > -----Original Message----- > From: Robert Bruninga [mailto:email@example.com] > Sent: September-17-07 7:44 PM > To: 'Stefan Wagener'; email@example.com > Subject: RE: [amsat-bb] GO-32 and APRS working! > > > APRS is working on GO-32. > > Saw W3ADO sending text messages. > > ................................................ > > "Fm W3ADO to APRS via 4XTECH* <ui pid=F0 LEN=40 > [18:27:41] > > > hello world. Bob just typing away... > > ............................................... > > I just left the receiver on the 435.230 (which is +5Khz) > downlink and heard > the satellite out over the Atlantic. SO I used HYPERTERM and > just typed > away.. With my OSCAR array and no one else logged on, I got > nearly 100% > digipeats of everything I typed. This was using the D700 in > packet mode. > > I also noticed that I could copy to the end of the pass while > still being > tuned 5 KHz high right on the published center frequency. > Makes me think > the satellite might actually be a few KHz higher than published? > > Also, since GO-32 is in "PTT" mode, meaning it does not keep > the TX on all > the time, this means there is a key-up delay for APRS UI > packets. This is > GREAT news compared to APRS via ECHO. This delay means there > is no problem > for the D700 or D7 users in seeing their own packets digipeated. > > On ECHO, being full duplex and always on, the turn around on > the satellite > was faster than the TNC in the D7 or D700, so you could > usually not see your > own packets. > > NOTE: Non APRS users, who want to "chat" in dumb terminal > mode, can use the > simplest APRS format to make sure all the mobiles and HT's > can see them. > That is, preceed each message line with the ">" character. > SO typing this: > > >Hello world... > > Will display nicely on the D7 and D700 radio front panels. > But they will > only see the first 20 bytes on the D7 and only the first 28 > bytes on the > D700. But usually keyboard contacts are short anyway.. Oh, > and be sure > your TNC UNPROTO is set to UNPROTO APRS VIA 4XTECH, and 9600 baud of > course... > > Bob, Wb4APR > > > > _______________________________________________ Sent via email@example.com. Opinions expressed are those of the author. Not an AMSAT-NA member? Join now to support the amateur satellite program! Subscription settings: http://amsat.org/mailman/listinfo/amsat-bb
AMSAT Home


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Another sad case of parents jumping to conclusion without actually checking the source material.
MOSCOW – A group of parents in the central Russian region of Ural called on President Vladimir Putin on Thursday to ban the popular "Death Note" manga series, complaining in an open letter to him that it is harmful to children.
According to local media reports, a 15-year-old girl left four "Death Note" comic books along with a suicide note before jumping from a window of her 13th-floor apartment in Yekaterinburg on Feb. 20.
Local police are investigating a possible connection between her death and the manga series, which details murders committed by putting the names of targets on a notebook given by Death.
In the letter, the parents of the girl demanded that sales of the books and related DVDs be banned, arguing that "Death Note" helps generate interest in death among children and badly affects their emotional development.
All 12 volumes of the "Death Note" series were translated and published in Russia by 2012.
Manga are so popular among Russian children and youngsters that they can be found at bookstores in regional cities. They also can be browsed on the Net for free thanks to Russia's inadequate copyright protection.
ღ - https://youtu.be/GSyXSeAHL_k - ღ
For a girl to go as far as taking her own life, there must have been something truly horrible going on in her life. It's depressing that her parents are pointing fingers at fiction while completely ignoring a probable much more serious issue.
This isn't something new in Russia it appears.
Read Umineko
RoyalMoon wrote:
This isn't something new in Russia it appears.
That was the first thing I thought of when I saw this. They might as well ban Naruto for having too engrossing of a story.
Ban everything that is entertainment, just in case someone who are sick in the head won't kill themselfs.
Pfft, yet another case of parents wanting to blame something other than themselves for their lack of parenting skills.
I didn't expect a kind of Spanish Inquisition!!
I'm pretty sure that's not the case. I think the living standard for those eastern Europe folks is still pretty bad, the parents beat their kids. The kid is fortunate to have access to manga comics for entertainment.
Ive never been to Russia, but if you ask me for my opinion I would say Russia is very ..beige, and bland. When everything is literally very beige and bland it affects the people's mood. I mean Ive seen some commercial on Russia TV channels before. Their cars are beige, their buildings are beige, even the food label in the grocery stores are so beige and lame.
Even their people are beige and lame. They shoot up opioids like Desomorphine(Krokodil); I mean at least my ancestors use a beautiful gold inlaid pipe to smoke opium not that it is a good thing, but back to the topic. These folks don't need more pain killer, THEY NEED METH.
Bottomline, communism did this, and they have yet to recover from it.
adventurous1701 wrote:
Pfft, yet another case of parents wanting to blame something other than themselves for their lack of parenting skills.
Took the word right out of my mouth. Willing to point fingers at everyone else but themselves for their failed parenting.
I'm the best in the world at being me;why would I give up such a great position?
They probably were horrible parents :3 Poor girl, at least she saw a epic manga book before jumping. o.o
Gintama' Yorozuya
Of course they will ban it even though millions of other people read it and suffered no suicidal depression.
These people need to get a grip, I find it hard to believe that anything like this can be blamed on a piece of fiction.
Though I do feel sorry for their loss, I think they are just looking for a convenient excuse.
Some of the people commenting should have some decency. You're jumping the gun too. What is it to you if it gets banned in Russia?
Yet another ridiculous idea. May as well ban everything else while they're at it. You never know what effect anything else will have on people after all
Considering how much suicide is a problem in Russia, banning the anime/manga/live action/other forms will not help.
I'm sure those parents DO want to blame someone or something other then themselves however, that doesn't mean they beat their kid or were abusive in any way. Sometimes parents try their best but just don't know what to do for their child. I think just saying she had crappy parents and they should be blaming themselves, is very ignorant. My parents were great when I was growing up, did everything right but I was still really depressed and really good at hiding it. Good grief people, have some compassion, they just lost their daughter!
That being said, I do think it's absurd to blame a manga for the poor girls death.
Only DEATH can cure STUPIDITY!!


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On 1 May 2008 at 2:44, SV1BSX wrote: > > > > > > The KEPS i used are from spacetrack i know someone recommend to take those > > who appears on the ops DELFI page. If its only a KEPS matter > > they should be quite far from the real orbit or something is moving in a > > funny way up there. > > > > I will try to listen sooner on the evening pass over here > > > > > > > > Luc Leblanc VE2DWE > > > ....CORRECT Luc ! Probably that is the point. The Keps form Delfi-page is > now with... 10 min's delay !!! > > I have sent a new file with Keps, where the Delfi is ...10 mins ahead from > previous Kepls! > > He sent it me a friend of mine and he said it's 100% accurate. > > I will try it also with these new Kepls today afternoon. I refresh my Orbitron KEPS Mak and i just hear DELFI C 3 very loud but there is another problem who come out. The audio was very unstable the tone frequencies where not stable and some distortion seems to appears during the data transmissions making RASCALS completely unable to decode even a single packet. Theses tones distortions gradually increased up to a point the transmitter shuts down. The tone pointer on RASCALS was moving wild smashing both side limit of the scale and it was not what i got the first time i decoded my first packets. Why the tone frequencies are no more stable even with doppler correction remain a mystery but surely the control team will come up with some explanations as they seems to be aware of this behaviour. End of the story and a night to speculate on the subject! Luc Leblanc VE2DWE Skype VE2DWE www.qsl.net/ve2dwe WAC BASIC CW PHONE SATELLITE _______________________________________________ Sent via firstname.lastname@example.com. Opinions expressed are those of the author. Not an AMSAT-NA member? Join now to support the amateur satellite program! Subscription settings: http://amsat.org/mailman/listinfo/amsat-bb
AMSAT Home


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NetWellness is a global, community service providing quality, unbiased health information from our partners. NetWellness is commercial-free and does not accept advertising.
Friday, September 11, 2015
Digestive Disorders
Diverticulitis requires surgery?????
Recently told I have diverticulosis and diverticulitis I am now facing surgery. What determines when one should have surgery? I am told they will take out 1ft of my bowel. Confirmed just recently and have had one more bout all within one month. Two types of antibiotics have been taken at once both times. After going off the first ones a few days later some discomfort returned. I was then put back on the Flagyl and Cipro. Are there any other forms of help?
It is estimated that about 20 % of patients with diverticulitis will require surgery. Some of these patients have surgery on an emergent basis in situations where the diverticulitis has progressed to peritonitis, abscess (localized infection), perforation (the bowel wall has ruptured), or obstruction (blockage). Other patients require surgery on an elective basis mostly because of recurrent attacks of diverticulitis or because of other non-emergent complications. It sounds like the latter scenario applies to your case. Before proceeding to elective surgery it is important that your doctors verify that your symptoms are from diverticulitis. This usually means confirming evidence of this condition by way of a CAT scan and also by direct visualization of the bowel wall using endoscopy (sigmoidoscopy or colonoscopy) to exclude other conditions that might mimic diverticulitis (such as infections, inflammatory bowel disease, and cancer).
John D Long, MD
Assistant Professor of Clinical Medicine
College of Medicine
University of Cincinnati


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This gets harder every year. Every year new games are released, old favourites are replayed, obscure indies capture our hearts, and games that we once knew are updated until they're unrecognisable. We're fickle, argumentative people in love with the most dynamic gaming platform on the planet, and we're only allowed to pick 100 games?
It should be the top 1,000, the top 10,000, to fit every single game we all love. But it's not. As much as the games change, our task remains the same. Boil down decades of sims and shooters, roleplaying games and real-time strategies, into the top 100. The best games on PC. Those that you must play, now .
Our international team of writers were asked to put forth their ten favourite games, in order. Those individual lists were then collated, a mega-list was formed, and each contributor was challenged to defend their love. Disagree with their choices? Look out for the beginning of the PC Gamer Readers' Top 100 soon on the site. You'll soon know the pain of having to choose. Until then: that Grand Theft Auto IV, eh? What a game.
100. Grand Theft Auto IV
Release Date: 2008
Last year: 15
Graham: I can't stand Grand Theft Auto's cruel, dull missions, so I used to be reliant on its buggy multiplayer if I wanted to have fun messing around in Liberty City. Thanks to a persistent modding community turning the game into a giant toybox, that's no longer true. Now, when I visit the city, it's packed with cars that can travel at infinite speed, and I'm a superman who carries a gravity gun. That the best way to enjoy this game has changed so much two years after its release is the perfect example of why PC gaming is great.
99. Red Orchestra: Ostfront 41-45
Release Date: 2006
Last year: New entry
Tim S: Quake 3 re-imagined by Remarque or Solzhenitsyn. An ecstasy of brutal fumbling, wild SMG fire, and cold, calculating elimination. What's not to like?
98. Ultima Underworld II
Release Date: 1992
Last year: 90
Tony: It wasn't just the graphics. You could pick stuff up. You could throw it. You could cast spells, repair your armour and fly. You could talk to the monsters. Wonderfully, richly, impossibly interactive, UUII was a game from the future. It took history a long time to catch up.
97. Max Payne
Release Date: 2001
Last year: New entry
Chris: Right when you start, you discover Max's murdered wife and child in his own home at the hands of drug addicts. Has there ever been a beginning of a game more powerful or emotional? Exceptional noir writing and a gritty NYC underbelly setting made Max Payne one of the greats.
Rich: Nothing like trying to gracefully launch Max into a room, guns blazing, only to have him dive headfirst into a doorjamb and very slowly rub his hair down the wood as he floated to the ground. Get up, try again, get it right, and you feel like king of the underworld.
96. Football Manager 2011
Release Date: 2010
Last year: New entry
Craig: Training? Pah! My tactics? Wild and confusing. I'm more of a hands-on kind of manager, giving people calming talks, asking for their advice, before taking my team on a long, unbeaten run in Europe. I've no idea about football anymore, but there are enough switches to flick so that doesn't matter.
Rich: After years of playing it safe and managing with a steady hand, I decided to go full-on mental in FM2011. I started insulting and praising players in the same breath, I changed my assistant manager's registered name to 'Wiggles', and I brought in half of the Slovakian national team. All turned out to be good decisions, and all explain why I love managing footballs.
95. Audiosurf
Release Date: 2008
Last year: 92
Craig: Man up, everyone. Favourite song to surf? I'll start: Girls Aloud's 'Biology'. It makes a super bouncy, fun track to dodge blocks to.
Graham: That was mine as well.
Rich: I like the songs that no one else is cool enough to like.
Craig: Ah, 'Sound of the Underground'.
Tom: I like Feist's version of Sea-Lion Woman - gentle opening, then bumpy with hand-claps, then batshit with a twisting guitar solo.
Cooper: Listening to music is fun and all, but if only there was a way to... play my music. Oh, there is? And it's psychedelic euphoria? Awesome, sign me up. Audiosurf makes a game out of your MP3 library, creating interesting, unique experiences for each song. The ability to "surf" every single song (and compare stats on an online leaderboard) makes it one of the most replayable games of all time, and adds incentive to getting into new bands. Actually, I wonder what sort of level Willow Smith's 'Whip My Hair' would make...
Josh: The faster, the better. I'll toss in any punk rock I can find.
94. The Last Express
Release Date: 1997
Last year: New entry
Richard: It's the eve of World War I, and Robert Cath is up to his ears in murder and intrigue on the Orient Express. Arguably Prince of Persia creator Jordan Mechner's magnum opus, it's one of the most atmospheric games ever made, notable for its use of real-time action and incredible attention to detail.
93. Splinter Cell: Chaos Theory
Release Date: 2005
Last year: 96
Craig: Splinter Cell: Convicton came pretty close to digitally heisting my heart in the action-spy genre I love, but while the action is sharper, more brutal, it misses Chaos Theory's wonderful characterisation of Sam: he threatens a man with death if he says "monkey" and has funny little chats with his boss. And the wonderful, tactile co-op is still the best of its kind.
92. Red Faction: Guerrilla
Release Date: 2009
Last year: New entry
Tom: The hostage rescue side quests made it for me. You're charged with breaking into an EDF base, untying the three captured rebels inside, and driving off with them alive. But these hostages can die. It's not game over, it just sucks. That makes me genuinely care about their survival, and I'll rip buildings apart to make sure they get out alive.
91. Mount & Blade
Release Date: 2008
Last year: New entry
Evan: The progression of a campaign in M&B feels like one of those scenes from a movie where someone enters a street and starts walking toward the camera, inviting along butchers, housewives and other sidewalk-people to join their happy jaunt. The difference is: you're a conquering swordsman or Robin Hooder, and you take that entourage of archers, pikemen and cavalry from castle to castle, liberating food from innocent farmers or slaying bandits along the way. Not to be overlooked for its graphics; it's the joy of archery, the best sieging you'll do in an action game, you can get married, and all while being a proper, open-ended RPG that makes you care about the troops you recruit in the same way that X-COM or Jagged Alliance might.
Click here to continue reading PC Gamer's 100 best PC games of all time.


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Will the replacement cast of "Steel Magnolias" fare better than the replacement refs in the NFL?
If you initially didn't have anything nice to say about a remake of the "Citizen Kane" of chick flicks, you could have sat with Queen Latifah, who didn't exactly jump at the idea, either.
"Obviously, I took pause," Latifah deadpans, knowing that the movie's legion of fans might feel that someone had swiped their wedding albums and replaced the photos of their favorite eccentric friends and relatives.
The remake, which airs on Lifetime, Sunday night at 9, boasts a predominantly African-American cast that includes Latifah, Phylicia Rashad, Adepero Oduye, Jill Scott and Alfre Woodard in the roles made famous in the 1989 movie by Sally Field, Olympia Dukakis, Daryl Hannah, Dolly Parton and Shirley MacLaine, respectively.
Rashad's real-life daughter, Condola, has the Julia Roberts role of Shelby, but is playing Latifah's daughter. There are a couple of men in the movie, too.
Along with "Golden Girls" repeats and women-in-peril movies, the original 1989 version of "Steel Magnolias" virtually defined what Lifetime was all about.
"Magnolias" always got great ratings, even if Lifetime threw it on at the last minute in order to make their numbers for the month.
Commercial breaks give fans time to replenish the bag of Cheetos and the box of Puffs.
Latifah says she was "lassoed" into the project by producers Craig Zadan and Neil Meron, who had worked with her on the movie versions of "Chicago" and "Hairspray."
She was sure that both of them had really lost it when they offered her the straight-laced Sally Field part of M'Lynn instead of one of the three scene-stealing, wise-cracking, supporting roles that seemed tailor-made for her comedic talents.
Latifah began to warm up to the idea when Zadan and Meron told her that the project had the blessing of "Steel Magnolias" playwright and screenwriter Robert Harling.
Harling felt that a predominantly black cast would be the one way to bring a fresh perspective to the material.
Latifah who signed on as both a co-star and executive producer, also agreed to a breakneck, 18-day shooting schedule.
Preparing for the movie was rough going. Her own mother was battling a serious illness, and learning the role of a mother who tragically loses a child brought back painful memories of her brother, who died in a motorcycle accident when he was 24.
Just when she thought it was safe to play Condola's mother, she was on the set staring at one of her own motherhood role models: Phylicia "Claire Huxtable" Rashad.
"That's my mama, that's America's mama," she said.
Studying the interplay between the Rashads, she got Phylicia's permission to steal their intimate, nonverbal gestures of quietly pointing at each other and softly touching each other's arms with their index fingers.
As for Sunday's "Magnolia" premiere, she says: "I plan to watch with my parents and a couple of bags of Funyuns, so we can stank up the joint a bit."
No word on whether Field has a rap album in the works.


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|The 2012 LET No.1 Carlota Ciganda from Spain
World No. 1 amateur Lydia Ko is part of a glamour grouping that will tee off early in the first round of the ISPS Handa New Zealand Women's Open hosted by Christchurch.
The young Kiwi star will be joined by world No. 19 ranked Angela Stanford (USA) and Europe's No 1 ranked Carlota Ciganda (Spain) in the opening round of the 54-hole tournament which is co-sanctioned between the Ladies European Tour and the Australian Ladies Professional Golf.
The fifth New Zealand Open, to be staged at Clearwater Golf Club, has attracted its strongest field with 14 players inside the world's top 100 led by Stanford along with three winners of majors in former world No 1 Laura Davies, Anna Nordqvist and Sophie Gustafson.
|Angela Stanford of the USA
The field includes the 2012 European No 1 ranked player, Carlota Ciganda, who became the first player since Davies in 1985 to win the LET's ISPS Handa Order of Merit in her rookie year. In her first full year on the Tour in 2012, the 22-year-old won the Suzhou Taihu China Open and the Deloitte Ladies Open as well as top five finishes in four other tournaments.
"I just like to play golf, to enjoy myself and play as well as I can," Ciganda said. "It is not pressure for me to be No 1. Last year I did not have much expectation because it was my first year. I was enjoying my time with friends and my caddy who is a good friend.
"The course at Clearwater is in good condition and it is looking very good – good greens, good fairways. I am looking forward to it.You need a good strategy because it is not easy with the wind. There are a few tricky holes in the front and back nine. It is the same for everyone."
Ko, the youngest player to win a professional tournament on the ALPG and LPGA last year, is already up to No 38 in the world.
Stanford has six professional wins to her credit including the prestigious HSBC Women's Champions in Singapore. In 2011 she finished top four in two of the four majors, the Kraft Nabisco Championship and US Women's Open.
The group starts from the first tee at 8.10am Friday, followed by the grouping of rising star Cheyenne Woods, (the niece of Tiger Woods), the 2011 NZ Open champion Kristie Smith of Australia and the inaugural champion Gwladys Nocera from France.
"Ever since I was five years old I watched Tiger play on TV and I always knew that it is what I want to be," Woods said. "Tiger has been a huge influence on me. The first time I watched him I was in a stroller. I've always been a huge fan; for him to be in my family is awesome and a huge motivation."
Woods is hoping for a fast start in the first three LET events of the season, last week at the Volvik RACV Ladies Masters in Australia, this week in New Zealand and next week in the Australian Open.
"I want to play well here. I have some European events on my schedule and I will also look to Monday qualify for some LPGA events and hopefully play well there too. The competition here is good with a lot of girls from Europe, the local Australian and New Zealand players and the LPGA players."
|Kiwi star Lydia Ko
On the other side of the draw is the grouping of Australian Stacey Keating, a two-time winner on the LET last year, the remarkable Davies, who has 81 professional wins to her credit, and two-time major winner Nordqvist (Sweden).
"I had to improve after last week in Australia," Davies said. "People think that I don't practice but that's not true. If I am playing well I don't need to practice. But I had a good session on the range and I am pleased with how I am hitting it. I am still motivated to win. The day I am not is the day I will hang up the clubs for good."
There are 144 players in the field including nine amateurs led by Ko, with a cut after two rounds for the leading 50 professionals and ties for the final round on Sunday.
ISPS Handa NZ Women's Open Feature Group Tee Times
First Tee:
8:10am Lydia Ko (a) NZL
Angela Stanford USA
Carlota Ciganda ESP
8:20am Cheyenne Woods USA
Kristie Smith AUS
Gwladys Nocera FRA
Tenth Tee:
8:30am Stacey Keating AUS
Laura Davies ENG
Anna Nordqvist SWE
8:40am Lee Anne Pace ZAF
Sophie Gustafson SWE
Karen Lunn AUS


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CLARENDON HILLS – The Clarendon Hills Park District's Active Learners Preschool, 315 Chicago Ave., is currently accepting registration for its fall 2013 program session.
In the fall, classes for "Terrific Threes" for 3-year-old students will meet from 8:45 to 11:15 a.m. Monday, Wednesday and Friday mornings, while the "Fantastic Fours Pre-K" program for 4-year-olds will meet from 12:30 to 3 p.m. Monday, Wednesday and Friday afternoons.
All activities at the Active Learners Preschool emphasize an early love of learning, skill development, positive self-esteem, new friendships and more.
The fall session begins on Sept. 11 and runs through Dec. 20. A $100 nonrefundable tuition deposit will hold a child's place in the preschool program for the coming session.
For more information, call 630-323-2626.


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Virto/Elcan Industries offers the SXE line of vibratory screeners for separation of problematic wet and dry materials. Main applications include safety screening and sizing classification of difficult-to-screen materials, typically in the range between 20 and 500 microns. The screeners have single or double-deck design and come in 2-, 3-, and 4-ft diam.
SXE Screeners operate in multifrequency vibratory-impact modes. These screeners provide uninterrupted self cleaning of the meshes, fluidization of powder, and de-agglomeration of powder clusters. This results in higher screening capacity, better separation, and more undersize yield, especially when compared to traditional and ultrasonic screeners.
Virto/Elcan units are designed for use with non-tensioned working meshes. The screeners offer simple, cost-saving on-site sieve replacement using pieces of nylon, polyester, or stainless steel meshes which simply cut-off from a roll. This feature eliminates the costs and problems that are usually associated with re-tensioning of conventional and ultrasonic fine screens.
Virto/Elcan systems are simple, easy-to-use, rugged mechanical devices that provide low-cost maintenance and yield improvements. Unlike ultrasonic or conventional separators, the screeners do not contain electronic or pneumatic parts. The patented powerful de-blinding system is completely mechanical and is activated from the vibratory motors.
Virto/Elcan Industries, Tuckahoe, NY 800-283-5526 www.virto-elcan.comElcan Industries Inc.


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NetWellness is a global, community service providing quality, unbiased health information from our partners. NetWellness is commercial-free and does not accept advertising.
Sunday, November 8, 2015
NetWellness receives many questions about uterine fibroids. Uterine Fibroids are benign (non threatening) tissue growths found in the uterus. Many women (as many as 50%) have uterine fibroids. Each woman's case is different and some women may require treatment for their fibroids while others may not. Fibroids vary in size, number, and location and can cause severe symptoms, moderate symptoms, or no symptoms at all. Only about 30% of women with fibroids require any treatment at all.
Here are some common symptoms of Uterine Fibroids:
Though many women with uterine fibroids experience some or all of the symptoms, many other women experience none at all. For this reason it is important to keep up to date with annual women's health exams. Part of the standard pelvic exam is designed to search for uterine fibroids.
A main concern for women with uterine fibroids is that they will inhibit fertility or make pregnancy impossible. Though uterine fibroids can make it difficult to become or maintain a pregnancy, the majority of women never have any problems. However, extra measures may need to be taken in order to help a woman with uterine fibroids conceive. If you have been diagnosed with uterine fibroids and are concerned about your future fertility consult your healthcare provider.
There are many treatments available for uterine fibroids. They range from more invasive procedures like surgery to less invasive procedures like hormone therapy. Here is a list of current treatments available:
If you have fibroids and have mild symptoms, your doctor might only suggest pain medication. Over-the-counter anti-inflammatory drugs, such as ibuprofen, or other analgesics can be used for mild pain. If pain becomes worse, your doctor can prescribe a stronger painkiller.
Other drugs used to treat fibroids are called gonadotropin releasing hormone agonists (GnRHa). They work by stopping the production of estrogen by the ovaries similar to menopause. These drugs can decrease the size of the fibroids since estrogen is needed to stimulate the fibroids to grow. Sometimes they are used before surgery, to shrink the fibroids, making them easier to remove. Side effects are a result of the loss of estrogen and can include hot flushes, vaginal dryness, depression, not being able to sleep, and decreased sex drive. Anti-hormonal agents, such as a drug called mifepristone, also can stop or slow the growth of fibroids. These drugs only offer temporary relief from the symptoms of fibroids; once you stop the therapy, the fibroids often grow back. Also, for a woman taking GnRHa, the loss of estrogen can have long lasting effects such as osteoporosis. For this reason, it is only used for a short time such as six months.
If you have fibroids with moderate or severe symptoms, surgery may be the best way to treat them. Here are the options:
Uterine Fibroid Embolization (UFE)
Uterine fibroid embolization (UFE) is a treatment where particles are released into the small blood vessels that supply the fibroids therefore blocking the blood supply to the fibroids so they shrink. UFE is proving to be an alternative to hysterectomy and myomectomy. The recovery time is also shorter, and there is a much lower risk of needing a blood transfusion than for these surgeries. Many women can have UFE and go home the same day. There is a small risk of infection in the treated fibroid, but these are usually managed with antibiotics. Recent studies also suggest that most fibroid tumors are not likely to re-grow after UFE, although more long-term data is needed.
Not all fibroids can be treated with UFE. All patients must first be evaluated with ultrasound or MRI to make sure the fibroids will respond well to this treatment. Doctors called interventional radiologists perform UFE. The best candidates for UFE are women who:
Sometimes after UFE, the particles that are put into the fibroids to cut off their blood supply have traveled to the ovaries decreasing their blood supply. In a few women, the ovaries then stop working for a short time or permanently. Although researchers know that UFE may affect how ovaries function, they are unsure of how exactly UFE affects fertility. Too few women have gotten pregnant after UFE for researchers to know if there is an increased risk of pregnancy complications. UFE is not considered an option for women who wish to retain the ability to bear children.
ExAblate® 2000 System
ExAblate® 2000 is a medical device that uses magnetic resonance image guided focused ultrasound to target and destroy uterine fibroids. The device is intended to treat women who have completed child bearing or do not intend to become pregnant. ExAblate® 2000 is non-invasive surgery.
ExAblate combines two systems - a magnetic resonance imaging (MRI) machine to visualize patient anatomy, map the volume of fibroid tissue to be treated, and monitor the temperature of the uterine tissue after heating, and a focused ultrasound beam that heats and destroys the fibroid tissue using high frequency, high-energy sound waves.
The treatment requires repeated targeting and heating of fibroid tissue while the patient lies inside the MRI machine. The procedure can last as long as three hours. The new device can be used to treat some - but not all - fibroids. Fibroids close to sensitive organs such as the bowel or bladder and those outside the image area cannot be treated.
This is still a fairly new procedure that needs more long-term data before being considered the standard of care.
This article is a NetWellness exclusive.
Last Reviewed: Dec 18, 2006
Formerly Associate Professor of Clinical Obstetrics and Gynecology
Director, Medical Student Education
No longer associated


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The three children of a NSW doctor who died after being allegedly attacked by her husband are being cared for by family friends, as the local community comes to grips with her loss.
The boys aged 13 and 18, woke to find their mother unconscious and badly injured in their home in Lithgow, west of Sydney, at about 8am (AEST) on Tuesday.
Local doctor Leonie Geldenhuys, 46, died at the scene from stab wounds.
Investigators later found the body of a 54-year-old man at another property at nearby Wolgan Valley.
Police confirmed the man - named by local media as Jakavas Geldenhuys - was the children's father and also a doctor, and said his death wasn't being treated as suspicious. It's believed the couple had been estranged.
The boys' 21-year-old sister, who studies in Sydney, returned to Lithgow on Tuesday to be with her brothers, according to Dr Asaad Baraz, who works at the Lithgow medical centre where Dr Geldenhuys practised.
"We spent a few hours yesterday talking about the whole thing," he told Fairfax Radio Network on Wednesday.
The three children were now together and staying with family friends.
"We will look after them, all of us. I was overwhelmed with the messages of support," Dr Baraz said.
It's believed there are no other family members in Australia.
Dr Geldenhuys migrated to Australia from South Africa with her family six years ago.
Dr Baraz said the Lithgow community was shocked by what had happened.
"She was very, very popular - everyone loved her," he said.
"She is a delightful lady, just delightful - there are no words that can describe our loss, she will be deeply, deeply missed."
Chifley local area command crime manager Luke Rankin said on Tuesday it had been a day of unimaginable grief for the two boys.
"It's unimaginable to them - first finding their mother deceased and then, as the day's gone on, we've had to inform them that their father's also been found dead," he said.
Homicide Squad detectives are investigating the death and will prepare a report for the coroner.
* Readers seeking support and information about suicide prevention should call Lifeline on 131 114 or the Suicide Callback Service on 1300 659 467.


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A Looker of a Loo: 10 of the Year's Best Bathroom Rehabs
I read recently that a person spends an average of 7 1/2 days in the bathroom each year. That's an entire week spent in what is often a very small space! No wonder we all want the room where we do our "business" to be a stylish and efficient. These 10 bathroom renovations from the past year would definitely make you feel number one while you're going number two.
• 1 Before & After: Andi & Dean's Master Bath on a Budget
• 2 Before & After: Jason's Beautiful Bathroom Remodel
• 3 Before & After: A Demo-Free Bathroom Renovation
• 4 Before & After: Contemporary Bathroom Remodel
• 5 Watching the Slow Progress of a Bathroom Gut Rehab
• 6 Before & After: The Boring To Bling Bathroom
• 7 Squeezing Shelving into a Small Bathroom Renovation
• 8 Bathroom Before & After: From Carpeted to Calm & Clean
• 9 Before, During & After: Small Bathroom Gut Renovation
• 10 Before & After: Bathroom Renovation by Frisson
Images: See linked posts for full image credits


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Jeff Horrigan reports on the Red Sox 6-5 extra inning win over the Blue Jays in Toronto. Amalie Benjamin looks at the importance of the Sox winning their second straight series on the road. Joe McDonald looks at the list of heroes in yesterday's game for the Sox. Dom Amore says that the Sox had to have this one, "and with the nose of a championship team they sniffed out a path to win it." Bill Ballou has the Sox feeling this was one they had to get.
Nick Cafardo has the bullpen coming up big for the Red Sox yesterday. John Tomase looks at the Red Sox getting a chance to really bury the Yankees over the next three games. Tomase also looks at Jed Lowrie, who hit the game winning home run yesterday, and is opening eyes with his poise and play for the Red Sox.
Benjamin's notebook looks at Ellsbury staying in the game after crashing into the fence hard while making a catch in the fourth inning. Horrigan's notebook has J.D. Drew slow to heal from his back injury and he could be headed for the DL. McDonald's notebook has more on the impact Lowrie has had with the Sox. Amore's notebook has Ellsbury too fast for his own well-being. Ballou's notebook has Ellsbury taking one for the team by remaining in the game.
Chris Warner over on Patriots Daily has the post-mortem from Friday night's stinker against the Eagles.
Christopher L. Gasper has the Patriots needing to find a way to shore up the specials teams coverage units, and fast. Karen Guregian has Vince Wilfork trying to deal with the reputation he has gotten as a dirty player. Stephen Harris says that it won't be as simple as flipping a switch for the Patriots to straighten out all their problems from this preseason. Robert Lee says that this week will be another full of questions about the status of Tom Brady.
Glen Farley has a look at punter Chris Hanson, who found himself getting a tongue-lashing from coach Bill Belichick during Friday night's game. David Brown examines the urgency to get things straightened out in the special teams units. Jennifer Toland has more on this phase of the game.
Gasper's notebook has the Patriots facing yet another short week of preparation this preseason. Lee's notebook has the Patriots refusing to use injuries and backups as the reason for their poor play this preseason.
Need another example of why Bill Belichick doesn't discuss injuries with the media? Consider what happened with the Giants over the weekend. Defensive end Osi Umenyiora left the game with an injury to his knee. Following the game, coach Tom Coughlin tells the media that the doctors "discovered no ligament damage through their initial exams." He also added that ""I'm thinking it's going to be OK."
The next day, after a more thorough exam and MRI, it was discovered that there was no ligament damage, however, Umenyiora will still miss the entire season with with torn cartilage in his left knee. Ouch.
It's not so much that Coughlin did anything wrong in this instance, but imagine the roller coaster ride that Giants fans went on this weekend. They see the injury, fear the worst, are comforted by Coughlin's words, and then devastated the next day when their Pro Bowl defensive end is out for the season.
In contrast, Belichick would've said nothing after the game, other than "The Doctors will take a look at it" and then the news would've come out by itself the next day, without the embarrassment of having the previous night's words ("I'm thinking it's going to be OK.") still hanging there in the minds of the fans. It's why Belichick will often say "I'm not a Doctor."
Again, it's no doubt frustrating for the media not to be able to get any injury information from the Patriots, but the upside is that you're not going to get inaccurate or "guessed" injury information from someone not qualified to talk about them, either.
Marc J. Spears has the US mens basketball team achieving their goal of returning the gold medal to the US for the first time since 2000. Bob Ryan says that by coming together, the US was able to reach their goal of redemption. Jeff Jacobs says that the US earned their redemption in this Olympics.
John Powers wraps things up with a sport-by-sport look at how the US did over in Beijing. Ryan says that the Chinese put on an Olympics that will be a tough act to follow.
Eric Avidon has the BC football team prepping for the season opener. Steve Conroy has coach Jeff Jagodzinski seeing a familiar foe in the Kent State Golden Flashes, even though the two programs have never played each other.


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Farmington man killed in Milton motorcycle crash.
September 29. 2013 12:09AM
MILTON -- A Farmington man was killed Saturday afternoon after losing control of his motorcycle and driving off the road into a wooded area.
State Police said Ryan Canney, 20, of Farmington was fatally injured in the crash, which happened at about 4:40 Saturday afternoon.
The crash remains under investigation. Investigators said they did not know why the motorcycle left the roadway.


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Goffstown's Bourque heads UNH hockey recuiting list
May 29. 2013 10:48PM
Goffstown native Collin Bourque headlines the incoming recruiting class for the University of New Hampshire men's ice hockey team. Bourque, a 5-foot-7, 155-pound forward, played for the New England Wolves of the America East Hockey League. He led his team in scoring with 36 goals and 78 assists for 114 points in 55 games last season.
Bourque helped the Wolves capture the AEHL Championship in its inaugural season. The coaches of the league named Bourque Player of the Year. He was also named to the league's first team.
One of Bourque's assistant coaches with the Wolves is Jon Fontas, captain of the 1978 University of New Hampshire men's ice hockey team and a member of the UNH Hockey Hall of Fame. Bourque played four years with Cushing Academy in Ashburnham, Mass.
UNH head coach Dick Umile announced the incoming recruiting class also includes defenseman Dylan Maller of Parkland, Fla., defenseman Matias Cleland of Longmont, Colo. and forward Tyler Kelleher of Longmeadow, Mass.
Maller played for the Tri-City Storm of the United States Hockey League. He played for the DC Capitals U-18 team in the North American Prospects Hockey League. He's eligible for the NHL Draft in June.
Cleland played for the Omaha Lancers of the USHL scoring nine goals and 28 assists in 60 games.
Kelleher comes to UNH after playing for the USA Hockey National Team Development Program, scoring 23 points in 23 games.


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Renzo Gracie fought on the UFC 112 card where Anderson Silva infuriated most of the known MMA world with his taunting of Demian Maia during their main event bout. Gracie is also connected with #1 middleweight contender Chris Weidman, who challenges Silva in one week at UFC 162.
In case you were wondering if Gracie and Silva's shared mother country would keep the Jiu Jitsu legend from talking smack about Silva – it won't. Speaking to The Fight Network, Gracie said, "Anderson is a guy that rubs many people the wrong way. He's not a humble guy."
Alright, so it's not exactly mother f_cking Silva, but Renzo does seem to mean it as a serious criticism.
"Even though he may speak humbly when he talks, when he's in the ring he doesn't act humble. He puts down his opponents. He acts in a way that again, we always know what is right and wrong, and by looking at that, we know it's wrong. It's like you can beat your opponent, but do it with respect," Gracie continued.
Saying Silva isn't humble is a bit like saying that Michael Jordan is arrogant. No kidding, and who really cares?
Throwbacks like Renzo, we suppose. Renzo might hold on to a choke way after a ref has stepped in, or stomp on the head of an opponent of one of his fighters after the bell, sure.
He's ruthlessly aggressive in fights but we can't ever remember him taunting opponents during the fight. He's all business, and it's a grimy business.
Check out the video above for Renzo's take on the bout as well as that of Weidman's striking coach, Ray Longo.


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Once the weather starts to cool and the days get a little bit shorter, nothing sounds better than wearing comfy clothes, snuggling under a blanket, lighting a candle, and cooking yummy comfort food.
And for the newlyweds who are beginning to build their home together, your registry is the perfect time to stock up on kitchen essentials that will help you make the warm food you crave during the chillier times of the year.
Here's what to register for.


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on the needlesWednesday, September 26, 2007
*sorry, for this post to pop up again, I got a little paranoid about showing those photos of the kids*
Every year I knit each of the children a sweater that coordinates with the others. They then wear it for the Christmas card photo. I promise I only subjected my husband to wear one for one year! Come on, it was the 90's, I think that may have been in. The funny thing is that I didn't wear one. I just wouldn't do that. This may be a little goofy for some of you, but I really do try to do something that isn't too goofy. Come on, they are kids.
(see, I am really trying hard to sell you on this idea)
I thought last year would have been the last year to do it. Now that I have a twelve year old, I thought that maybe he is at that age where it may be a little goofy to wearing a coordinating sweater with his siblings. Patterns are also next to impossible to find for this age.
However, I just couldn't put my little thing to rest. The yarn has been chosen.
41 comments
LOL for Monica's observation about your high standards...ReplyDelete
You've chosen some handsome coordinating colors and the sweaters will be age-appropriate, so why the heck not?
Love that rosy pink :o)
Three sweaters...by November? Now, I'm as irrational as the next knitter, but that strikes me as possibly just the slightest bit excessive. Even if they are kid sweaters. Of course, this is from a mom who has managed exactly three Christmas card photos in ten years, so we're not talking Grand Champion Momming here. More like, limping-by- until-they're-grown-up momming.ReplyDelete
No need to sell any of us on the idea, it's fantastic! And if anyone can whip those babies out by November, I do believe it's you!ReplyDelete
I think it's a great tradition to continue on even when they are grown adults. C'mon, you gotta have something to embarass them with when they look back (in this case, they'll be proud of you!). The yarn selections are absolutely perfect. And, am so impressed how fast you knit up your projects. I think am also heading towards less sleep and more knitting...the holiday list is long!ReplyDelete
Love it! And LOVE the yarn colors! :) I may have to try that with my 3...they're a bit smaller, so it would be easier on me! I really like the coordinating but not identical thing... :)ReplyDelete
Oh I think that is a beutiful idea, and not goofy at all. I love the sweaters in the pics. And the yarn you've picked for this year looks wonderful too. Can't wait to see your end results.ReplyDelete
I'm sticking with hats right now, need to update my blog with a few pics, hopefully soon.
Well, I'm not entirely sold on the family knits idea but I love that you aren't making identical sweaters for the kids. And besides, you have great taste so your kids are lucky to get a new sweater from you every year!ReplyDelete
I'm working on a Sunrise Circle in that same color of Skye Tweed. I think it's such a pretty color.
I was dressed the same as my sister for years and I hated it because we are sooooooo different. Having said that I think this idea is beautiful as they are 'co-ordinating' and it's just such a lovely family tradition. I love that they will probably look back and go 'oh Mum that was sooo goofy' - that's what families are all about! I love the wool you have selected and can't wait to see the vest - very cute!ReplyDelete
Oh that is so cute, OK, maybe a little scary but somehow I actually want to copy you. I love family traditions and I think it is such a lovely thing to do for your family, they will remember all the love in these sweaters and it will make them feel all warm inside when they need to.ReplyDelete
That is a great idea! Love it! And love that you are doing the Cobblestone sweater and adjusting it to fit your boys - that looks like such a great pattern. I have yet to knit my husband a sweater and if I ever get around to it Cobblestone is the front runner!ReplyDelete
Wait a sec… 3 sweaters in one month! Wow! I know you can do it!
When I had a family portrait taken 5 years ago of all of us, the photographer suggested matching outfits. He had several samples in his studio and it did look gorgeous. I think they are adorable.ReplyDelete
I am making the cobblestone pullover also, and in the same color. It was hard finding the yarn because it was discontinued. I do hope that it softens up when I block it because right now it is too itchy for my DH to wear. The yarn just might become an afghan while I hunt for something else softer. This is my first time using this yarn. I should have tested for this before I started. Have you used this yarn before?
From what I could tell, your choice in sweaters for all of the kiddos were in great style choice! Quite fashionable. The Cobblestone sweater is so cool. You blow my mind everytime I see the things you knit, not only knit but at such a quick pace. Amazing and lovely.ReplyDelete
wow, you are ambitious! I thought I was shooting high with stockings for all - nothing close to you!! It will be fun to see them done!ReplyDelete
I tend to set extreme goals for myself, as well. good luck on yours! I love your tradition of knitting sweaters for your children.ReplyDelete
This comment has been removed by the author.ReplyDelete
Coordinated sweaters are cool, especially for the holidays, dont you remember Bridget Jone's boyfriend and his reindeer sweater?!ReplyDelete
I love the idea!!ReplyDelete
I do cards each year. Usually I have sewn the outfits. The oldest two put a stop to my fun a few years ago. LOL
We still do a kid card but no outfits. We did Santa hats in the hot tub...they liked that. Last year we wrapped the dog in Christams lights with them all with her....she did it for biscuts. Gotta love that dog!
Time to start thinking of something for this year!!
the cobblestone is really, really gorgeous. thanks for the action shots.ReplyDelete
I totally love the finished product but this looks really intimidating. I'm really impressed you can keep all of this straight and come out with a sweater that's beautiful. Wow!ReplyDelete


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Release date: March 27
Funeral Services for Dr. Bill Hardage
|A private graveside service will be held for Dr. Bill Hardage on Friday. A memorial service will be held at 1 p.m. at First Baptist Church in Plainview. Konerstone Funeral Directors are in charge of the arrangements. Visitation with the family will follow in the FBC Parlor.
The family has asked that memorials be given to the Hardage Scholarship Fund. Those gifts can be directed through the Office of Advancement.
Condolences may be sent to the Hardage family at 3402 SW 8th St., Plainview, TX 79072.


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Posted 20 September 2012. PMN Crop News.
Monsanto to Introduce Acceleron Seed Treatment Products With New Generation Fungicide in 2013
Multiple modes of action provide continuous protection against key soybean diseases
Source: Monsanto Company Press Release. www.monsanto.com
St. Louis, Missouri (September 4, 2012)--Fungal diseases are major causes of poor emergence and stand development in soybeans. But farmers will have a stronger line of defense in 2013 with Monsanto's planned introduction of Acceleron® Seed Treatment Products with a new-generation fungicide for soybeans and cotton.
These seed treatment products contain multiple modes of action to deliver more complete and consistent disease protection, including a new fungicidal active ingredient.
•Unprecedented defense against Rhizoctonia and Fusarium, with a new active ingredient.
•Continuous protection from seed and seedling diseases.
•Broad-spectrum insect protection.
"Acceleron Seed Treatment Products with the new generation fungicide, in combination with other management practices, can help protect against these damaging seedling diseases, enabling farmers to achieve more uniform stands, higher yield potential and better return on investment," said Davie Wilson, Monsanto Seed Treatment Product Development Manager.
The products are being evaluated in Monsanto field trials this season. The objective is to compare performance in terms of stand development and total stand survival, vigor enhancement and, ultimately, yield. In some plots, time-lapse photography was utilized to capture differences in emergence and early-season plant growth and health. While the focus is on disease, the trials also compared early-season insect protection.
Acceleron Seed Treatment Products for soybeans are designed to complement and help maximize the performance potential of Genuity® Roundup Ready 2 Yield® soybeans. They provide an early-season advantage of improved early-season vigor and stand establishment with superior protection from seed and seedling diseases and early season insect pests.
For additional information, farmers can contact their seed representative or ag retailer or visit www.acceleronsts.com.


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Carbon Neutral
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1. Omega-3 Fatty Acids
Omega 3 fatty acids are essential nutrients for dogs and cats, meaning that their bodies cannot make these particular fatty acids; they must be obtained in the diet. Our modern American diet typically contains way too many pro-inflammatory Omega-6s. Since most commercial pet food is made from the 'leftovers' of human food processing, pets too get a ton of Omega-6s in their food, but little if any Omega-3s.
"The most important Omega-3 fatty acids for our pets are EPA and DHA"
EPA is found in every cell membrane and helps these vital membranes stay fluid and flexible; EPA is also a potent anti-inflammatory. DHA is important in the development and maintainence of the eyes, the brain, and the entirenervous system.
Some companies add flaxseed or other vegetable sources of Omega-3s to their pet food, but the truth is that dogs and cats are unable to convert plant-based oils into EPA and DHA. The ideal sources of Omega-3 fatty acids for pets are marine oils (such as wild salmon or sardine oil) that can be directly used by the body. Select a product made from fish that live in clean waters, are harvested sustainably, and are tested for freshness, purity, and absence of toxins and pollutants such as mercury, PCBs, and dioxins.
2. Digestive Enzymes
Digestive enzymes enable our pets to properly and completely break down food, so that the nutrients can be efficiently absorbed and utilized by the body. Incomplete digestion can allow certain food particles may trigger inflammation and the many chronic health problems associated with it. Cooking and processing destroys food's native enzymes, so it's crucial to add them to your pet's food. Plant- or fungal-source enzymes are able to work in the widest range of internal conditions.
"The product you select should contain at least four basic enzymes: protease (to break down protein), amylase (to break down starch), lipase (to break down fat), and cellulase (to break down plant cell walls so nutrients can be accessed)."
3. Probiotics
Probiotics, such as L. acidophilus, Bifidobacteria spp., beneficial strains of Streptococcus, and other 'friendly' beneficial bacteria, are important for maintaining a balanced, healthy gut; and to prevent harmful bacteria likes Salmonella from gaining a foothold. A diverse, healthy intestinal bacteria population also supports and modulates the immune system, and manufactures essential B vitamins and Vitamin K.
For pets with digestive issues, such as chronic vomiting or diarrhea, constipation, hairballs, or similar issues, probiotic supplements are extremely helpful. For pets who are, or have been, taking antibiotics, which kill friendly bacteria as well as invaders, probiotics are absolutely required. It's best to give probiotics while the pet is on antibiotics (2 hours apart from the medication), as well as for at least 2 weeks afterwards to hele re-establish a normal population.
Antioxidants are specialized molecules that scavenge and neutralize 'free radicals' in the body. Normal amounts of free radicals are made by the body and used by the immune system as weapons against viruses, fungi, and bacteria. However, excess free radicals can damage normal cells and create chronic inflammation. This chronic inflammation and free radical accumulation (oxidative stress) are major factors in aging. Excess free radicals are produced in response to many features of modern life, including vaccination; radiation from electronic devices, cell phone towers, and even sunlight; and stress.
"All pets can benefit from supplemental antioxidants to cope with the stresses of modern life."
All pets can benefit from supplemental antioxidants to cope with all these stresses. For pets who eat processed pet food, adding antioxidants is especially important. Antioxidants work together synergistically, so it's best to select a product that has a range of antioxidants in it, such as Vitamin E, carotenoids (such as beta-carotene and lycopene), and flavonoids (such as Vitamin C and quercitin).
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We always offer you the lowest of the sale price, the price with a coupon code discount, or the Auto Delivery price. You can tell which one applies because it will say "Sale Savings:" if the item is on sale and that is the lowest price, "Coupon Savings:" if you have applied a coupon code discount and that is the lowest price, or "Auto Delivery Savings:" if you selected Auto Delivery and that is the lowest price.


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Man accused of trying to take officer's gun, resisting arrest
Cyr was charged with attempting to take a firearm from a law enforcement officer, criminal mischief, simple assault, resisting arrest and unlawful possession of alcohol.
He was being held on $50,000 bail.
Police were initially called Friday around 3:30 a.m. for a report of two men fighting in the street. The caller told police that one man was lying in the roadway and the other had fled on foot toward Haverhill Road.
The two men were found and taken into custody.
As officers turned their attention to 11 Stonegate Lane, four people took off on foot into the woods. Police said several other occupants were intoxicated and under 21 years old. Two people inside the residence became combative but were eventually subdued and taken into custody, police said.
One of them, Eric Greenwood, 21, of Methuen, Mass., shattered the rear window of a cruiser with his head, police said. Greenwood was also charged with resisting arrest, criminal mischief, disorderly conduct, prohibited sales and simple assault.
Cyr attempted to grab Officer Joseph Freda's firearm during a struggle, police said.
Freda was able to stop Cyr but sustained a hand injury. Freda was treated and released at Parkland Medical Center.
Police also charged Edward Colon, 22, of Methuen, Mass., with possession of controlled drugs and simple assault.


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Thursday 10th May, 2012
1:00pm to 1:45pm
Content management is becoming less about management, and more about delivery. The management of content is being trumped by the enhancement and promotion of content post-publish.
This trend is pushing more and more power to marketing automation tools over traditional content management and publishing tools. More and more, vendors are leading demos with things like A/B testing and campaign management, and not even bothering to cover core concepts like content modeling and page editing.
This session is discuss the key differences between content management and delivery, and the state of the marketing automation industry — where it came from, where it is now, and what's the horizon for it.
Finally, we'll look at the management/delivery bifurcaton in the context of what it means for the CMS purchasing process. Will it be up-ended to the point where marketing automation tools lead and content management tools follow? Will buyers start their projects with the marketing suite and look to content management to support those tools? In this kind of marketplace, where does core content management fit in, and has it — or will it — become a commodity?
Deane is a Web developer, a partner in Blend Interactive. and blogs at gadgetopia.com bio from Twitter
Sign in to add slides, notes or videos to this session
United States United States, Philadelphia
8th–10th May 2012


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WEBTRACKKER training offers successful professionals for the Java training. If you think for Java training in Noida then connect simply with WEBTRACKKER training.
The training was very good and it cleared all the concept related to hadoop online training. Also the trainer is very good as trainer as he bring lot of his project expertise which helps in understanding the concept. I would love to go with other online courses related to my expertise which is offered by Webtrackker.
WEBTRACKKER training offer Java training with operational professionals in Noida, if you want Java training in Noida then join only with WEBTRACKKER training.
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WEBTRACKKER training center is one the paramount placement institute for Java in Noida because WEBTRACKKER training has very good tie-up with corporate companies in Noida forJava placements. Thanks
6 Week Industrail Training in Noida - We offer 4/6 Weeks Industrial to students from domains like CS/IT, MBA. Such programs are usually for 4/6 weeks where our experienced trainers impart practical knowledge, share their industry experiences, and prepare the young candidates to face the challenges of industry and assimilate in the corporate environment. With live project-based trainings, in webtrackker 4/6 Weeks Industrial program helps to improve the overall job-placement rate as students face interviews more confidently, exhibit problem-solving skills, develop a broad outlook and gain industry exposure. Hence, candidates who understand the practical application of concepts are readily hired by corporate.
Through our project-based 6 Week Industrial Training workshops, Multisoft trainers practically build upon theoretical concepts covered at the college level and provide live project trainings. Students are able to solve problems in a real-time environment that opens a window to the professional world. They become more confident, as well as find a connection between their chosen field and required industry standards.
4 & 6 WEEKS/MONTHS industrial TRAINING IN NOIDA - Webtrackker's industrial industrial training programs aims to train you on different platforms with live industrial projects and to give you the high quality IT training that will help you to find yourself in a respected position. The internship has designed in such a smart way that the students could get familiar with industrial professional. The 6 Weeks Project based industrial training proposes a blend of learning solutions, classroom training, seminars, continuous support and coaching. We are committed to ensure that the training helps the trainees/students to achieve their academic and career goals. We are available to conduct trainings either at our premises or at your College/University.
Webtrackker Technologies offers 4 & 6 Weeks Live Project Based industrial Training program in Java, Php, Web Designing, Android, Plc, Networking, .Net technologies in Noida, Delhi/NCR, India for MCA/BCA/BE/B.Tech/MSc(CS & IT )students & professionals.


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The Digital Transportation Exchange (DTE) would connect citizens, businesses, state and local governments, industry, entrepreneurs, researchers, and investors though a public private partnership like never before—creating a thriving marketplace for transportation solutions.
The DOT is interested in (1) engaging a wide variety of stakeholders on the potential for this initiative to connect people and technology for transportation innovation and (2) identifying partners to launch and manage this platform. Participate in this exciting dialogue through three easy steps:
Explore the Concept
Additional detail about the initiative concept can be found in the project concept and accompanying presentation.
Participate in the Conversation
There are several ways for you to provide your feedback and discuss this concept with the DOT. A few are highlighted below. For more details on how the Department will receive comments, please see the Federal Register Notice entitled "Notice of Market Assessment and Public Meeting for Digital Transportation Exchange."
The DOT is looking for feedback on a few questions in particular, though general comments are also encouraged:
- Use: How would you use the DTE? What transportation topics should the DTE focus on? How do you think the concepts of using shared /interactive technology (DTE) can best be used in the transportation industry? Given what you currently know about the use of DTE related concepts, are there any additional functions that would be needed for you to use it most effectively?
- Connecting People: How can in-person /face-to-face interactions compliment the online DTE? If so, what kinds of activities would best connect people and technology to stimulate transportation innovation?
- Managing Partners: Who are the critical partners that should be involved in launching and maintaining the DTE to ensure its success?
- Challenges in Transportation Technology: In your opinion, what are the greatest challenges for integrating the use of shared/interactive technology (DTE) in the transportation industry?
- Transportation Innovation: What strategies would you use to stimulate innovation in this era of using shared/interactive technology in the transportation arena?
- Public Private Partnerships: Can you suggest specific opportunities to build public/private partnerships as they relate to the DTE?
Join the Conversation Online
- Submit ideas, thoughts, and comment about our concept and partnerships
- Comment on ideas and thoughts presented by others
- Find out what people are talking about
- The online comment period runs from August 11 through September 23
Review Materials from the Stakeholder Meeting Held at DOT Headquarters on September 16, 2011
The stakeholder meeting provided a forum for the Department to discuss any comments received to date on the concept and allowed stakeholders to work together on any of the outstanding issues remaining on the concept.
Stay Informed
Subscribe for updates on the DTE initiative to stay informed about:
- The request for partners
- Updates for developers, investors, entrepreneurs and other stakeholders on new opportunities to participate in the DTE
For more information on this effort and other DOT Open Government Initiative please refer to the DOT Open Government page at or contact the DOT Open Government team at firstname.lastname@example.com.


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August run means hot temperatures and high humidity. Since I decided to sleep in, I didn't get my butt out the door till after 930 am to run.
I like being an ultra runner. It means I can have a full breakfast and still go off and run right afterwards. I had an egg, tomato, and Ezekiel Bread if you're interested.
I was happy to step on the scale today and see I have shed the 'vacation pounds' *8* that I had gained. I'm now back to 20 lbs gone, and am working on more.
It was tough conditions out there, did alot of hiking. My clothes were totally soaked through, even the skirt, by the time I finished up.
I was really tempted to take a dip in the lake. But it's about the temperature of bath water, then I would smell like algae, on top of sweat. So I by passed that.
This is actually the secret entrance to the bridle trail. There's a deer path through here.
So, 7.6 miles down for the day. Training (and eating) has been going well!


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Updated first post.
the most recent nightly builds support USB2 mass storage devices now. USB2 requires HBC v1.0.8, and HBC itself must use IOS58.
See hackmii.com
Hope you like it
Wow! This is truly excellent! Thank you for your hard work, dhewg!
Excellent, indeed. After updating my HBC and such to get IOS58 support, I found this forum that explained why my ScummVM install stopped being able to read my hard drive. Updated it to a nightly build and voila! 7th Guest on my TV again!
Thanks for the great support and a great program.
I cannot get the DVD of games I just burned to work with the latest nightly build of ScummVM-Wii. When I click on "Add game," it only lets me select directories on the SD card. Do the nightly builds have DVD support or am I going to have to compile my own build?
EDIT: Nevermind, I got it working. I didn't realize you had to press "1" and then mount the DVD. Maybe this info could go into the "Readmii" file?
Will there be a 1.4.1 Release for the Wii?
I would love to see usb2.0 support and the newest release on the wii.


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At the most basic level, an organism's sleep-wake rhythms are governed by 10 known genes. In the fly, two of those genes -- period and timeless -- produce proteins that fluctuate in a negative feedback loop that takes about 24 hours to complete. At night, two other genes (clock and cycle) stimulate production of Period and Timeless proteins, which begin to accumulate in the cell's cytoplasm. After about six hours, the two proteins move into the nucleus; their presence turns off the genes, which then remain inactive until Period and Timeless degrade and the whole cycle begins anew.
Michael Young, the Richard and Jeanne Fisher Professor at Rockefeller University and head of the Laboratory of Genetics, isolated the first circadian gene, period, in 1984. He and his peers have been piecing together the cellular circadian puzzle ever since, and thought they had some of the basics figured out. Prior studies, which examined the placement of Period and Timeless during different stages of the cycle, seemed to indicate that the two proteins idle in a cell's cytoplasm until they bump into each other and then, bound together, enter the nucleus. But Young and Pablo Meyer, who was then a graduate student in Young's lab, used a novel method to show that this scenario was far too simple.
Meyer, a physicist by training, found himself frustrated by how little he could see of what was occurring in a cell. "The truth is, we really don't know, mechanistically, what happens in the cytoplasm, and how things are being done in such a precise way," Meyer says. So he turned to a technique invented in 1948, called fluorescence resonance energy transfer; FRET gauges interactions between proteins by fluorescently tagging them and measuring how they react to different wavelengths of light. But although the technique can provide useful information, it's so complicated that researchers rarely use it. And no one had ever thought to use it to follow proteins in a single cell for an extended period of time.
"This begins to measure all these biochemical interactions inside the cell," Meyer says. For the first time, Period and Timeless could be tracked within a cell for eight hours or longer. "No one had ever labeled the components to follow them over time, to see one clock as it ticks away in a single cell," Young says. "All the biochemistry and molecular biology that had been done on this had been piecing together information from dead flies." But now, instead of freeze-frames, they had a movie.
The movie allowed them to follow the interactions between Period and Timeless with a resolution never before possible. They discovered that, rather than randomly colliding, the two proteins bind together in the cytoplasm almost immediately and create what Young and Meyer refer to as an "interval timer." Then, six hours after coming together, the complexes rapidly break apart and the proteins move into the nucleus singly, all of them within minutes of each other. "Some switch is thrown at six hours that lets the complex explode. The proteins pop apart and roll into the nucleus," Young says. "Somehow, implanted within the system is a timer, formed by Period and Timeless, that counts off six hours. You have a clock within a clock." He notes that this precise timer shows how carefully orchestrated interactions between proteins really are.
Young and Meyer, who's now a postdoctoral researcher at Columbia University, have yet to figure out exactly how the timer works, but its discovery opens up the door to a whole new suite of questions. "How does this interval timer tick? Is it made from additional proteins? Is this the only such timer in the circadian clock? Each of these questions are ahead of us," Young says. "A couple of years ago, we had identified lots of genes and had this sweeping picture of how circadian clocks work. But this indicates that there are much more formidable properties of the system that were overlooked."


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