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People collect , display, and analyze data to describe social or physical phenomena in the world around them. After collecting and organizing data, the next step is to display it in a manner that makes it easy to read—highlighting similarities, disparities, trends, and other relationships, or the lack of, in the data set. After this, the final step of analysis can occur. The methods students use to display data as they move through the primary and intermediate grades include making tables, charts, bar graphs, line graphs, pictographs, circle graphs, and line plots. Students in middle and high school also create histograms, box-and-whisker-plots, scatterplots, and stem-and-leaf plots.
When students decide how to display data and go through the steps to create that display, they learn which type of graphs are useful in displaying the different types of data, and the advantages and disadvantages of each display. They also learn how a graph may be selected and manipulated to misrepresent the data-for example, by choosing intervals along an axis that make a line graph seem to go up or down precipitously or make the differences between bars on a bar graph seem to be very great or very small.
It is important for teachers to highlight ways in which different representations of the same data can convey different information and to emphasize the importance of selecting representations suited to the particular mathematical tasks at hand (Moschkovich, Schoenfeld, and Arcavi 1993).
Students' experiences in displaying data should progress from the concrete, to the pictorial, to the abstract. When creating bar graphs, for example, they may progress from using objects, such as blocks or pieces of candy, to using sticky notes, to creating single-bar graphs, to using a color key to identify different bars of a double-bar graph. From the beginning, students should learn to label graphs with a title, the labels for each axis (x and y), the units of analysis (e.g., feet, meters, dollars) and how to create a key. Over time, students should learn the names of the different parts of different graphs.
Human rhinoviruses (HRVs) are common respiratory pathogens associated with mild upper respiratory tract infections, but also increasingly recognized in the aetiology of severe lower respiratory tract disease. Wider use of molecular diagnostics has led to a recent reappraisal of HRV genetic diversity, including the discovery of HRV species C (HRV-C), which is refractory to traditional virus isolation procedures. Although it is heterogeneous genetically, there has to date been no attempt to classify HRV-C into types analogous to the multiple serotypes identified for HRV-A and -B and among human enteroviruses. Direct investigation of cross-neutralization properties of HRV-C is precluded by the lack of methods for in vitro culture, but sequences from the capsid genes (VP1 and partial VP4/VP2) show evidence for marked phylogenetic clustering, suggesting the possibility of a genetically based system comparable to that used for the assignment of new enterovirus types. We propose a threshold of 13% divergence for VP1 nucleotide sequences for type assignment, a level that classifies the current dataset of 86 HRV-C VP1 sequences into a total of 33 types. We recognize, however, that most HRV-C sequence data have been collected in the VP4/VP2 region (currently 701 sequences between positions 615 and 1043). We propose a subsidiary classification of variants showing > 10% divergence in VP4/VP2, but lacking VP1 sequences, to 28 provisionally assigned types (subject to confirmation once VP1 sequences are determined). These proposals will assist in future epidemiological and clinical studies of HRV-C conducted by different groups worldwide, and provide the foundation for future exploration of type-associated differences in clinical presentations and biological properties.
Human parvovirus 4 infections are primarily associated with parenteral exposure in western countries. By ELISA, we demonstrate frequent seropositivity for antibody to parvovirus 4 viral protein 2 among adult populations throughout sub-Saharan Africa (Burkina Faso, 37%; Cameroon, 25%; Democratic Republic of the Congo, 35%; South Africa, 20%), which implies existence of alternative transmission routes.
Infections with human parvoviruses B19 and recently discovered human bocaviruses (HBoVs) are widespread, while PARV4 infections are transmitted parenterally and prevalent specifically in injecting drug users and hemophiliacs. To investigate the exposure and circulation of parvoviruses related to B19 virus, PARV4, and HBoV in nonhuman primates, plasma samples collected from 73 Cameroonian wild-caught chimpanzees and gorillas and 91 Old World monkey (OWM) species were screened for antibodies to recombinant B19 virus, PARV4, and HBoV VP2 antigens by enzyme-linked immunosorbent assay (ELISA). Moderate to high frequencies of seroreactivity to PARV4 (63% and 18% in chimpanzees and gorillas, respectively), HBoV (73% and 36%), and B19 virus (8% and 27%) were recorded for apes, while OWMs were uniformly negative (for PARV4 and B19 virus) or infrequently reactive (3% for HBoV). For genetic characterization, plasma samples and 54 fecal samples from chimpanzees and gorillas collected from Cameroonian forest floors were screened by PCR with primers conserved within Erythrovirus, Bocavirus, and PARV4 genera. Two plasma samples (chimpanzee and baboon) were positive for PARV4, while four fecal samples were positive for HBoV-like viruses. The chimpanzee PARV4 variant showed 18% and 15% nucleotide sequence divergence in NS and VP1/2, respectively, from human variants (9% and 7% amino acid, respectively), while the baboon variant was substantially more divergent, mirroring host phylogeny. Ape HBoV variants showed complex sequence relationships with human viruses, comprising separate divergent homologues of HBoV1 and the recombinant HBoV3 species in chimpanzees and a novel recombinant species in gorillas. This study provides the first evidence for widespread circulation of parvoviruses in primates and enables future investigations of their epidemiology, host specificity, and (co)evolutionary histories.
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Microservices architecture is a hot topic today. It has begun to challenge the traditional monolithic architecture and bring customers over to its side. Migrating to microservices is a common trend for many companies. It is driven by the modern market influences and demands: flexibility, agility, scalability, a quick reaction to changes and customer-centricity.
Actually, the hype surrounding microservices is worth noticing, as this architectural model offers to build a loosely coupled infrastructure with the best user experience. Thus, it can be a great fit for some businesses. But keep in mind that a non-monolithic system is not suitable for every use case. To remain monolithic or to migrate — that is the question. You should know the requirements adopting microservices in order to decide on the proper architecture for the system you are working on.
In this article, we will talk about the microservices architecture vs monolithic architecture , compare their main features, advantages and disadvantages . This will help you make a decision on which structure to choose for your enterprise.
What is monolithic architecture? Or, to be more precise, what is a monolith in the IT industry? Monolithic architecture is a software development pattern in which an application is created with a single codebase, a single build system, a single executable binary and multiple modules for business or technical features. Its components work together, share the same memory space and resources. From the definition of monolithic, it follows that a monolithic application is a cohesive unit of code.
This approach has been used for years to develop enterprise apps, as the industry was focused on desktop devices with browsers that didn't requireapplication platform interfaces (APIs).
Almost any big and successful app we use today was started as a monolith, since this architecture works well at the initial stage of the project. Let's define monolithic benefits .
In general, advantages of monolithic architecture imply simplicity in every aspect.
There are lots of websites with millions of visitors that were built as one large monolith. Some of them will probably continue working in this mode for a couple of years, but most of the companies are striving to split up their products into microservices. This is happening because of some significant disadvantages of the monolithic applications. The difficulties become particularly noticeable when the service and the team expand.
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Chris Moyles claimed to be second-hand car dealer to save up to £1m in tax
EX-RADIO 1 DJ Chris Moyles claimed to be a second-hand car dealer in a bid to save up to £1 million in tax, a tribunal has found.
The 39-year-old and two other men were named by a tax court as having taken part in a scheme called "working wheels".
Members included "450 fund managers, celebrities and other high earners between 2006 and 2008".
The scheme worked by allowing its members to say they had incurred large fees while working in the second-hand car trade, which they could claim back against their tax bill.
A published judgment from the Tax Chamber of the First-tier Tribunal said Moyles's self-assessment tax return for the financial year ending on April 5, 2008 - when he was presenting Radio One's Breakfast Show - said he "had engaged in self-employment as a used car trader".
"Chris Moyles did not give evidence directly to the tribunal but did submit 'a brief witness statement'"
Moyles did not give evidence directly to the tribunal but did submit "a brief witness statement".
The tribunal, under Judge Colin Bishopp, described that evidence as "very brief and rather uninformative".
The judgment said: "It is however quite clear from the statement that he too entered the scheme for no purpose other than to achieve a tax saving, and that he took no interest in the trade."
It went on to say that Moyles was "anxious to be reassured that the scheme was lawful, and that he would not have to undertake any trading himself".
It said his accountant, a Mr Smith, had "agreed that the scale of Moyles's borrowing was driven solely by the amount of the tax loss he wanted to achieve, in his case £1 million, and that the trading was not carried on for its own sake but was merely a means to an end".
Exchequer Secretary David Gauke said: "This case is another example of why taxpayers should not fall for the promises of promoters selling schemes that are all too often too good to be true.
"Not only will the taxpayer waste money on the fees for these failed schemes, they will still have to pay all the tax, interest and penalties that are due.
"This Government has provided HMRC with the resources to tackle these avoidance schemes and HMRC will now pursue the other users of the scheme to make sure all the taxes that are due are paid."


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Wednesday 22nd June, 2011
2:30pm to 3:15pm
Have you always wanted to write more python, but you feel lost in the syntax, style and semantics? Well, Python hackers like to toss many phrases around to describe the style of their code; "Pythonic" being one of the most popular. But what does this really mean?
In this talk, we will go over:
Sign in to add slides, notes or videos to this session
United States United States, Portland
21st–24th June 2011


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I have been waiting for this phone – I have resisted so far from buying an iphone even though I am 100% an Apple girl. I want one but let's face it – it's so expensive.
Apple iphone = Blogging Productivity? 🙂
Apple iphone = No clothes, make up or bags 😛
Apple iphone – worth it? (I am currently a crackberry user and a nice little thing it is but so slow and limited in functions…)


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Featured News - Current News - Archived News - News Categories
VA Western New York Healthcare System will celebrate African American History Month with events throughout February taking place in Freedom Hall, Room 301, 3495 Bailey Ave., Buffalo.
The first event, African American Vendor's Day, will take place from 10 a.m. to 2 p.m., Friday, Feb. 1.
"Taste of Soul" will take place on Friday, Feb. 15, from 11 a.m. to 1:30 p.m. African American dishes such as collard greens, sweet potatoes, pig's feet, and much more will be served. All events are open to the public.
A Black Film Festival will be held from noon to 1 p.m., featuring "Red Tails" with part 1 on Feb. 20 and part 2 on Feb. 21. "A Soldier Story" part 1 will be shown on Feb. 27 and part 2 on Feb. 28.


text: For patients and visitors For patients and visitors at Randall Children's Hospital We want your child's stay with us — or your visit — to be as pleasant and comfortable as possible. If you have questions, please call 503-276-6500. The information below is specific to Randall Children's Hospital. Here's more information that applies to all Legacy hospitals. Courtesy services Bank machines: US Bank cash machines are found on the first floor of Legacy Emanuel Medical Center Hospital — up the ramp/stairs from the main lobby and in the atrium near the Heartbeat Cafe. Gifts can be purchased at two locations: Emanuel Hospital Gift Shop - on the first floor by the hospital's main entrance of the hospital. Open seven days a week. Phone: 503-413-4272 The Gallery in the Atrium - Located on the first floor of the Medical Office Building Atrium (501 N. Graham). Offers gifts and other small items. Open Mon.-Fri. Phone: 503-413-4338 Healing gardens are on third floor and between the Randall Children's Hospital and Legacy Emanuel Medical Center. Interpreter services: The hospital has access to interpreters for a number of foreign languages. Your nurse will be happy to provide more information this free service. Lost and found items can be inquired about by calling Safety/Security Services at 503-413-7911. Mail, flowers and balloons will be delivered to the patient's room or forwarded to a home address if the patient has been discharged. (No flowers or plants in critical care areas.) Because many patients are allergic to latex balloons, please don't bring them to the hospital. (Mylar balloons are allowed.) Newspapers are available in the front lobby outside the main entrance. Notary services are available to patients free of charge upon availability. Ask your nurse for more information. Prescriptions can be filled at The Apothecary, an outpatient pharmacy in the atrium of Legacy Emanuel Medical Center - open Mon.-Fri., 9 a.m. to 6 p.m. and Saturday, 10 a.m. to 4 p.m. Phone: 503-413-4225 Fax: 503-413-4515. Televisions are provided in each patient room. Wireless Internet service is available in specific areas of the hospital; please ask your nurse. Dining All patients receive nutritionally balanced meals, including those with special dietary needs, at these times: Breakfast, 7:30 to 8:30 a.m. Lunch, noon to 1 p.m. Dinner, 5 to 6:30 p.m. Guest trays may be ordered for visitors; just ask your nurse. A cash payment will be collected on delivery. Snacks and drinks are available at the Kite Cafe in the lobby of Randall Children's Hospital. The Courtyard Cafe, the hospital's cafeteria, is on the first floor of Legacy Emanuel Medical Center, east of the main lobby. It features light snacks, hot entrees, grill items, salad bar and more. The Hearbeat Cafe is located in the atrium of Legacy Emanuel Medical Center. It is open 24/7 and offers free deliveries in the hospital. Vending machines: Basement—down the hall from the main surgical waiting area and at the opposite end of the basement First floor—just inside the atrium Second floor—around the corner from Lactation Services Lodging Please see this page of information about lodging for patients and families. Parking/transportation Free parking is available in our lighted parking structure close to the hospital lobby entrance and in other posted visitor areas. See a campus map. Security escorts are available around the clock to escort you to your car in hospital parking lots. Call extension "0" from inside the hospital or 503-413-7911 and we'll be happy to assist you. Bus schedules are available in the hospital lobby, by calling TriMet at 503-238-7433, or by consulting the TriMet website. Randall Children's Hospital at Legacy Emanuel is served by Routes 2, 24 and 44. Patient discharge areas Main entrance on N. Gantenbein Avenue, one block west of N. Vancouver Avenue North entrance, next to Emergency Services entrance 501 N. Graham, Medical Office Building 2 entrance (south side of hospital) 2919 Kerby Ave., Day Surgery entrance Patient/Family guides and unit fact sheets Family Guidebook: English or Spanish Randall Children's Hospital Phone Numbers Unit Fact Sheet: - Children's Day Surgery Unit Fact Sheet: - Cancer and Blood Disorders Program and Day Treatment Center Unit Fact Sheet: - Inpatient Units (Floors 4,6,7,8) Unit Fact Sheet: - Neonatal Intensive Care Unit Unit Fact Sheet: - Pediatric Intensive Care Unit Safety Electrical equipment - Due to government safety codes, the only items you may use in patient rooms are battery-operated shavers, radios, clocks and laptop computers. Please leave all other electrical equipment at home. Tobacco-free policy - Legacy Health is now entirely tobacco-free. (If you're trying to quit, we can help!) Zero Now Patient Safety Initiative - Randall Children's Hospital is committed to the quality, safety and value of the care that we provide. Our people, patients, community and world deserve to have a children's hospital where transforming the safety and quality of care we deliver is a never-ending priority. "Zero" is the only acceptable goal related to patient safety, and one that we all strive for. That is why we've created our Zero Now program to guide us in our journey to zero preventable harm. Spiritual care Chaplains are available 24 hours a day and may be reached through Spiritual Care at 503-413-4151 or the switchboard operator, "0." Your pastor, rabbi, priest or other faith representative is welcome to visit during your hospital stay. The Chapel of the Incarnation is on the first floor of Legacy Emanuel Medical Center and is open at all times. A brief, informal interfaith worship service is held on Wednesdays and Sundays at 11:30 a.m. Visiting hours Visiting hours are generally between 11 a.m. and 9 p.m., but can vary according to patient needs. Please keep in mind: Patient security and health. Providing our patients, families, visitors, staff and doctors with a secure and healthy environment is important to us. All families/visitors need to check in with the security guard next to the elevators in the main lobby. Learn more. Patients need care. Mornings and early afternoons are busy times for patients, doctors and nurses. Treatments, personal care and consultations usually happen between 7 a.m. to 3 p.m. Patients need rest. Please keep visits brief and limit the number of visitors. On the day of surgery, check with the nursing staff before entering a patient's room. If you'd like to call a patient's room phone, please do it before 9 p.m. Patients need privacy. You may be asked to leave briefly during procedures, treatments, or other care activities. Guidelines for Community Groups and Special Events To help your group plan an effective, enjoyable visit for our children and families, we ask that you observe these guidelines.


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I'm a Homeschool Dad
- Timothy Palla Homeschool Enrichment
- 2012 13 Feb
Hello, my name is Tim, and I'm a homeschool dad. (Other homeschool dads, please respond with a unanimous, "Hi, Tim.")
My wife and I have five children and have been involved in homeschooling since 1993. By the grace of God we have seen our two oldest sons graduate and are happy to report that they are well-adjusted, hardworking, intelligent young men. Our three younger children seem to be following suit. During our home education years, we have experienced many ups and downs, joys and disappointments, struggles and triumphs. Our lives have been deeply enriched at every bend in the road, but it didn't always seem like it at the time, especially when that bend spiraled down a steep mountain or took a U-turn back to Square One.
Running the Gamut
When we started out, my wife Jennifer researched and initiated the whole homeschooling endeavor. She answered all of my questions and kept me informed of all her ideas. It seemed as though, during this phase of our journey, I was the student. The most important part of my participation was to provide a listening ear and an open mind. I encouraged her as best as I could. We trusted each other because, at the heart of it all, our goals were identical: we both wanted our children to love God and serve Him. Desiring that their minds be shaped by biblical truth, and knowing that the standard options were not all that plausible, we gave homeschooling a unanimous vote.
From the fall of 1993 through the spring of 2000, Jennifer carried 99% of the burden. She taught our little boys to read and write, follow directions, add, subtract, multiply, divide, spell, study, memorize, and a plethora of other skills which have carried them well into life. While I worked 8:00 a.m. to 5:00 p.m. at my secular job, she worked as teacher, mommy, and manager of a growing household. I had no idea how multitask-proficient she was until the autumn of 2000, when I became fully submerged into the Palla Home Educators Union.
January of that year brought an enormous blessing from God. The church which I had been pastoring for the past nine months voted to take me on full-time. The blessing enlarged when they allowed me to have an office in my home rather than at the church. It was during the summer that my wife and I decided to make some new arrangements in our homeschooling process. Starting September 2000, the two oldest boys would have desks in my study, making me their new supervisor and enabling Jenny to work closer with our two younger boys while caring for our baby girl. It was an unforgettable year for all of us, to say the least.
My reason for sharing this Palla family history is to provide some minor background on my involvement as a homeschool father. You see, I went from occasionally helping with flash cards and reading bedtime stories to becoming a full-fledged principal, music instructor, and school administrator. Both my wife and I made many vital discoveries during this operation: the most important was identifying that I was more effective at educating adults than children.
Resigning from my multiple positions at the end of my first school year was a decision Jenny and I made together. It was a wise one. My ministry at the church was growing, and the demands were increasing—which was a good thing for both of us. She was able to do miracles with our three youngest children during my short-term office, and she willingly resumed the Head Schoolmaster position in the fall of 2001. It's funny now, but even the children looked forward to her return. Even so, I was not off the hook entirely—nor did I want to be.
Homeschool Heartburn
There are probably many fathers who feel left out of their children's lives. They hate being on the outside looking in, but they are not sure when, how, or where to make changes. They already know that God has commanded them to love their children and "nurture and admonish" them in the "things of the Lord." They are unable to forget the Lord's command to be the spiritual leaders of the home (thanks to all those little "As for Me and My House" wall plaques). They are even able to quote from memory a handful of Bible verses that exhort them to take responsibility for their children's education and spiritual development.
Nevertheless, adding one more scoop to their already overloaded plate seems to induce intense nausea and heartburn. For this reason, many fathers will deliberately choose to be left "outside." Odd as it may seem, it is an attractive alternative to jumping in, becoming overwhelmed, getting frustrated, and feeling like a total failure. A man's ego can be quite fragile.
Women may argue—and yes, I suppose there is some truth to the fact—that people find a way to do "what they really want to do." Dads can find time for hunting, skiing, fishing, boating, four-wheeling, mountain biking, camping, football, baseball, soccer, basketball, and (in my case) horseback riding. So if men really wanted to be successful and godly fathers and bless their wives, they would bite the bullet and be more involved in family leadership and home education. "Take the bull by the horns" . . . right? Not necessarily, so hold off a little before you start pouring that guilt gravy all over our plates. Allow me to speak freely from my heart.
Of course I wanted to be involved. I'd gladly take on the responsibilities of home leadership. It was my desire to bless my wife and children, but taking the bull by the horns does not necessarily make someone a professional matador or a cowboy. In my case, the bull was taking me down, scaring me, trampling me, humiliating me, and ultimately, causing a rift—no, a death—to the relationships and calling that God had given to me. Was it truly God's will to push me into utter failure? I was frustrating everyone, most of all myself! My sincerity and genuine love for my family could not possibly be judged by my level of involvement at this time. Being a part of my children's social, academic, and spiritual development would have to manifest itself gently if I was to grow into a respected, godly leader.
Discovering a Niche
After I relinquished all my involvement as a homeschool father, God began flooding me with His wonderful grace. Believe it or not, He started a completely new work in me by using skills which I already possessed—and felt comfortable teaching. As my children and I spent time riding and showing horses, building fences, working in the yard and garden, hiking the hills and spending lots and lots of time on 4-H projects (a.k.a unit studies), the Lord revealed to me that I was already a qualified home educator. The passion and gift to lead and train were already in me. Leading devotions and training for sports events was a breeze, because I had confidence in those subjects. Even so, as my children's interests grew outside of my areas of expertise, I began to grow with them.
Little by little, my involvement gained new territory. Soon I was helping with grammar and composition, not just flash cards and spelling words. About this time I began doing some freelance writing (for HSE) and decided to take classes at a local college to polish my written and oral communication skills. This naturally led to more active engagement with my children in their essay assignments, literature requirements, and creative writing projects. This dad was no longer a casual observer, on the outside looking in. My self-confidence was now lifting me to a new level of homeschool participation—one which I had never thought possible—and this time I was enjoying it.
A new day had dawned in my life. I had uncovered a talent which had been there all along. Now instead of taking the bull by the horns or avoiding the bull altogether, I could lead him around gently, calmly, confidently. Even the bull seemed to enjoy the new me. It became increasingly easy to make more room on my plate for those high-priority, healthy portions from God—without feeling overwhelmed and under-qualified. No more nausea, heartburn, or even hiccups. Oh, what a relief! I still devoted the main portion of my day to the work of the church ministry, but I no longer shirked or shied away from my responsibility as a father who is commanded to train up his children. The abundance of grace which God gave to me was now flowing freely into the lives of my wife and children.
The Goal that Unifies
The one special key that turned my attitude around was most certainly the grace of my wife. Jennifer is a wise and godly woman who saw my struggles as a homeschool dad and sought for simple, guilt-free, depressurized solutions which would enable me to save face. She truly lightened my burden. I may have been ignorant about a lot of things, but she never let me feel like a failure. Although she (and my children) desperately needed my help at times, I never felt pressure to be Superman. Perfection was not the standard, nor was it the goal. Giving my best—or close to it—was the acceptable, reasonable service. She seemed grateful for any amount of participation I gave, which made me want to give more. She frequently shared her homeschool "discoveries" with me (without any condescension), which piqued my renewing interest. My ideas were always considered and many suggestions were implemented. Jennifer successfully drew me back into the process of homeschooling with her consistent display of grace.
In many ways, homeschooling is nothing more than learning to "bear one another's burdens" and fulfilling the law of God (Galatians 6:2). It is one more path the Almighty uses to unify a man and his wife, enabling them to become one whole person. As they seek to meet each other's needs, their marriage relationship grows stronger. Should either spouse become selfish, the process backfires and two emotionally wounded individuals end up parting ways (figuratively or literally). Remember that God originally designed man to be lonely and in need of gracious help (the Bible calls a wife a "helpmeet" or "suitable helper"). God also designed a wife to need affection, support, and family commitment from her husband. As homeschooling fathers and mothers ingrain these eternal truths into their hearts, they will begin to lift each other's burdens with Christ-like grace. This act of faith will always please God, and He, in turn, will enable them to succeed—for His glory, the harmony of the home, the good of the children, and the testimony of Jesus Christ. And that is what being a homeschool dad is really all about.
*This article published February 1, 2010.
Timothy Palla is a pastor, freelance writer, horseman, artist, and musician, but his greatest joy is serving the Lord and loving the "wife of his youth," Jennifer. They have five children: Drew, Dane, Aidan, Ethan, and Meghan. Together, Tim and Jenny have been committed to homeschooling since 1993. You may contact Tim at firstname.lastname@example.com.
Originally published in Home School Enrichment Magazine. Now, get a FREE subscription to HSE Digital by visiting www.HSEmagazine.com/digital Every issue is packed with homeschool encouragement, help, and information. Get immediate access to the current issue when you start your FREE subscription today!


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A Placebo-controlled Study of Efficacy & Safety of 2 Trough-ranges of Everolimus as Adjunctive Therapy in Patients With Tuberous Sclerosis Complex (TSC) & Refractory Partial-onset Seizures (EXIST-3)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01713946
Recruitment Status : Completed
First Posted : October 25, 2012
Last Update Posted : February 1, 2018
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
This study will evaluate the efficacy and safety of two trough-ranges of everolimus given as adjunctive therapy in patients with tuberous sclerosis complex (TSC) who have refractory partial-onset seizures.
The study consists of 4 phases for each patient [Baseline phase: From Screening Week -8 (V1) to randomization visit at Week 0 (V2)], Core phase, from randomization at Week 0 (V2) to Week 18 (V11)], Extension phase from Week 18 (V11) until 48 weeks after the last patient has completed the core phase, and Post Extension Phase.
|Condition or disease
|Tuberous Sclerosis Complex-associated Refractory Seizures
|Drug: RAD001 Drug: Placebo
|Phase 3
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|370 participants
|Intervention Model:
|Parallel Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Official Title:
|A Three-arm, Randomized, Double-blind, Placebo-controlled Study of the Efficacy and Safety of Two Trough-ranges of Everolimus as Adjunctive Therapy in Patients With Tuberous Sclerosis Complex (TSC) Who Have Refractory Partial-onset Seizures
|Actual Study Start Date :
|April 29, 2013
|Actual Primary Completion Date :
|October 2, 2015
|Actual Study Completion Date :
|October 25, 2017
Experimental: Everolimus low trough
everolimus titrated to 3 to 7 ng/mL
Drug: RAD001
Other Name: Afinitor, Votubia
Experimental: Everolimus high trough
everolimus titrated to 9 to 15 ng/mL
Drug: RAD001
Other Name: Afinitor, Votubia
Placebo Comparator: Placebo
Drug: Placebo
- European Medicine Agency (EMA): Response rate [ Time Frame: Baseline, Week 12 ]Response means at least a 50% reduction from baseline in partial-onset seizure frequency
- Food & Drug Administration (FDA): Percentage reduction in partial onset seizure frequency [ Time Frame: Baseline, Week 12 ]Percentage reduction from baseline in partial onset seizure frequency during maintenance period of the core phase.
- Seizure free rate [ Time Frame: Baseline, Week 6, Week 18 ]Seizure free means a 100% reduction in partial onset-seizure frequency
- Proportion of patients with at least a 25% reduction in partial onset seizure frequency [ Time Frame: Baseline, Week 6, Week 18 ]
- Categorical variable of six levels of reduction from baseline in partial-onset seizure frequency [ Time Frame: Baseline, Week 6 to 18 (during maintenance of core phase) ]Six levels of reduction: (≤ -25% (exacerbation); > -25% to < 25% (no change); ≥ 25% to < 50%; ≥ 50% to < 75%; ≥ 75% to < 100%; 100% (seizure-freedom)
- Frequency of seizure free days [ Time Frame: Week 6, Week 18 ]
- Treatment duration [ Time Frame: Week 0 (randomization), Week 18 ]Time from randomization until treatment discontinuation in the Core phase
- Overall Quality of Life global scores [ Time Frame: Baseline, Week 18, and End of Treatment (time when patient completes or leaves study. Range from 74 to 142 weeks) ]Taken from the 3 age-specific questionnaires
- Sub-test scores for neurocognitive, neurodevelopmental, and neurobehavioral tests [ Time Frame: Baseline, 18 weeks (End of Core), Every 6 months during Extension, End of Treatment Extension (time when patient completes or leaves study. Range from 74 to 142 weeks) ]Changes in the Vineland Adaptive Behavior Scales-II and the Wechsler Non-Verbal Scale of Ability
- Percentage reduction in seizure frequency/frequency of selected adverse events [ Time Frame: Baseline, end of study (if patient completes range from 74 to 142 weeks) ]
- Pre-dose concentrations of anti-epileptic drugs (AEDs) alone and post-baseline (AEDs plus everolimus) [ Time Frame: Baseline, Week 3 ]
- 50% response rate from Baseline by time interval over the extension phase [ Time Frame: Week 18 (start of Extension), End of Treatment Extension (time when patient completes or leaves study. Range from 74 to 142 weeks) ]
- Seizure free days in partial onsent seizure by time interval over the extension phase [ Time Frame: Week 18 (Start of Extension), End of Treatment Extension (time when patient completes or leaves study. Range from 74 to 142 weeks) ]
- Frequency of adverse events [ Time Frame: Baseline, End of Treatment Extension (time when patient completes or leaves study. Range from 74 to 142 weeks) ]
- Frequency of abnormal laboratory values [ Time Frame: Baseline, End of Treatment Extension (time when patient completes or leaves study. Range from 74 to 142 weeks) ]
- Frequency of Columbia Suicide Severity Rating Scale (C-SSRS) outcomes [ Time Frame: Week 8 (screening), End of Treatment Extension (time when patient completes or leaves study. Range from 74 to 142 weeks) ]
- Frequency of serious adverve events (SAEs) referring to a positive suicidal evaluation [ Time Frame: Week 8 (Screening), End of Treatment Extension (time when patient completes or leaves study. Range from 74 to 142 weeks) ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|2 Years to 65 Years (Child, Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
1. Male or female between the ages of 2 and 65 years (except in Europe where minimum age will be 1).
2. Clinically definite diagnosis of TSC per modified Gomez criteria 3. Diagnosis of partial-onset epilepsy according to the classification of the International League Against Epilepsy (1989) and revised in 2009.
4. Uncontrolled partial-onset seizures; must meet the following:
- At least 16 reported quantifiable partial-onset seizures over the Baseline period with no continuous 21-day seizure-free period between Visit 1 (Screening Visit) and Visit 2 (Randomization visit), as per data captured in daily seizure diaries.
- Prior history of failure to control partial-onset seizures despite having been treated with two or more sequential regimens of single or combined antiepileptic drugs.
- Prior or concurrent use of vagal nerve stimulator (VNS) is allowed. If the patient is using VNS, device stimulator parameters must remain constant throughout the study.
Prior epilepsy surgery is allowed if performed at least 12 months before study entry.
5. Must be receiving one, two, or three AEDs at a stable dose for at least 4 weeks at the start of the 8-week prospective Baseline phase, remain on the same regimen throughout the Baseline phase, and intend to continue the same regimen throughout the 18-week double blind Core phase (rescue medications are permitted).
6. If female of child bearing potential, documentation of negative pregnancy test at time of informed consent and must use highly effective contraception during the study and for 8 weeks after stopping treatment 7. Sexually active males must use a condom during intercourse while taking study drug, and for 8 weeks after stopping study treatment 8. Hepatic, renal and blood laboratory values within the following range at screening :
- AST and ALT levels < 2.5 x ULN
- serum bilirubin <1.5 × ULN (this limit does not apply to patients with an elevated indirect bilirubin, if they have Gilbert's Syndrome),
- serum creatinine < 1.5 x ULN
- hemoglobin ≥ 9 g/dL
- platelets ≥ 80,000/mm3
absolute neutrophil count ≥ 1,000/mm3 9. Written informed consent. Subjects or their legal guardians must have the ability to comprehend the informed consent form and be willing to provide informed consent.
10. Patient or caregiver must be able to reliably record seizures and keep a daily diary and recall adverse events.
Exclusion Criteria:
1. Patients with seizures secondary to metabolic, toxic, infectious or psychogenic disorder or drug abuse or current seizures related to an acute medical illness.
2. Presence of only non-motor partial seizures (NOT APPLICABLE per Amendment 2) 3. Patients with TSC who have SEGA in need of immediate surgical intervention. 4. Patients under 2 years of age with untreated infantile spasms. 5. Within 52 weeks prior to study entry, an episode of status epilepticus as defined in the protocol.
6. Patients with history of seizure clusters (where individual seizures cannot be accurately counted according to the judgment of the investigator) occurring within 26 weeks prior to study entry.
7. Patients who require rescue medication during the baseline phase for more than 6 days 8. Patients with non-TSC related progressive encephalopathy. 9. Patients who weigh less than 12 kg. 10. Patients with coexisting malignancies within the 3 years prior to randomization, except for adequately treated carcinoma of the cervix or basal or squamous cell carcinomas of the skin.
11. Patients with any severe and/or uncontrolled medical conditions at randomization such as:
- Symptomatic congestive heart failure of New York Heart Association Class III or IV, history of left ventricular ejection fraction (LVEF) < 50%, QTc interval >460ms, congenital QT syndrome, unstable angina pectoris, myocardial infarction within 6 months of study entry, serious uncontrolled cardiac arrhythmia or any other clinically significant cardiac disease.
- Significant symptomatic deterioration of lung function
- Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of everolimus (e.g., ulcerative disease, malabsorption syndrome or small bowel resection).
- liver disease such as cirrhosis, decompensated liver disease, and chronic hepatitis
- Uncontrolled diabetes as defined by fasting serum glucose > 1.5 × ULN.
- Active skin, mucosa, ocular or GI disorders of Grade > 1.
- Active (acute or chronic) or uncontrolled severe infections.
A known history of HIV seropositivity or other active viral infections. 12. Patients with an active, bleeding diathesis. 13. Patient with uncontrolled hyperlipidemia: fasting serum cholesterol > 300 mg/dL OR >7.75 mmol/L AND fasting triglycerides > 2.5 x ULN.
14. Patients who have had a major surgery or significant traumatic injury within 4 weeks of study entry.
15. Patients with a prior history of organ transplant. 16. Patients receiving more than 3 antiepileptic drugs at any time in the baseline phase or at randomization or who change the dose of the AEDs during 4 weeks before screening or during the baseline period.
17. Patients being treated with felbamate, unless treatment has been continuous for ≥ 1 year.
18. Patients currently receiving anticancer therapies or who have received anticancer therapies within 4 weeks of study entry (including chemotherapy, radiation therapy, antibody based therapy, etc.).
19. Prior treatment with any investigational drug within the preceding 4 weeks prior to study entry.
20. Patients receiving chronic, systemic treatment with corticosteroids or another immunosuppressive agent at study entry. Topical or inhaled corticosteroids are allowed.
21. Patients who have received prior treatment with a systemic mTOR inhibitor (sirolimus, temsirolimus, everolimus) within 24 months of study entry. Patients who have received prior treatment with a topical mTOR inhibitor (sirolimus, temsirolimus, everolimus) within 4 weeks of study entry.
22. Patients with a known hypersensitivity to everolimus or other rapamycin-analogues (sirolimus, temsirolimus) or to its excipients.
23. Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study 24. Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test.
25. Patients with a Score of 4 or 5 on the Suicidal Ideation item within 2 years of Screening, or any "yes" on the Suicidal Behavior item of the Columbia-Suicide Severity Rating Scale at Screening or Baseline , who upon follow up with a healthcare professional are found to be severely depressed or suicidal.
26. Maintenance of a diet consisting of <40 g of carbohydrate per day within 3 months of screening
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01713946
Show 103 Study Locations
|Study Director:
|Novartis Pharmaceuticals
|Novartis Pharmaceuticals
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Novartis Pharmaceuticals
|ClinicalTrials.gov Identifier:
|NCT01713946 History of Changes
|Other Study ID Numbers:
2011-000860-90 ( EudraCT Number )
|First Posted:
|October 25, 2012 Key Record Dates
|Last Update Posted:
|February 1, 2018
|Last Verified:
|January 2018
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
|Plan Description:
Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations.
This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
Keywords provided by Novartis ( Novartis Pharmaceuticals ):
TSC seizures,
TSC epilepsy,
mTOR inhibitor,
Additional relevant MeSH terms:
Tuberous Sclerosis
Pathologic Processes
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Neoplasms, Multiple Primary
Neoplastic Syndromes, Hereditary
Malformations of Cortical Development, Group I
Malformations of Cortical Development
Nervous System Malformations
Neurocutaneous Syndromes
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Congenital Abnormalities
Genetic Diseases, Inborn
Antineoplastic Agents
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Anti-Bacterial Agents
Anti-Infective Agents


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Are you playing any these days? Looking for a partner to rally with. Thanks
Bummer!! Thanks for the reply back...would be great to have you on the team. If you drop down (for whatever reason) to 4.0, please keep us in mind. We would love to have you at Northdale.
Be well.......Michael (firstname.lastname@example.com)
PS: we will run some socials and scrimmages if you ever want to jump in do not hesitate to contact.
Greetings Laura,
I hope this note finds you well. I have a mixed doubles team I captain out of Northdale and I am looking for a strong 4.0 female player. Not sure if you are still in town, but if you are interested and can play as a 4.0, would love to have you come to practice.
Be well........Michael (email@example.com)
Hi Laura,
Do you have time to hit today?
Hi Laura,
Just saw your comment to me, 7 months later that is. I would love to play anytime. Let me know.
What can you do here? At Tennisopolis, you can:
- network with your tennis friends. Invite your tennis friends and build your network now.
- meet new players. Here's a primer on how to find partners.
- join a Group. Members have started over 400 Local Groups (and other types of Groups too.) Search for one in your area, or start your own.
- follow the pros. There are over 1900 blog posts on Tennisopolis. Have a good read, or write your own.
- improve your game. Get tips in the Forum and check out video lessons.
- post your own Videos and add your own Photos.
Thanks to everyone inviting their friends, we now have over 25,000 members. Invite yours too!
If you need any help, let me know.
Friend me!
© 2018 Created by Mark / The Mayor. Powered by


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Thursday, October 01, 2009
VeganMoFo 1: Eating From the Garden!
Week One of VeganMoFo: Eating From the Garden!
Today's seasonal meal: Hummus plate with fresh veggies. Yummy, super quick, filling, and beautiful. I always feel like I digest better when my food is beautiful.
The purple beans and the tomatoes are from our garden (and everything else is from the farmers' market). I love those beautiful dark purple green beans... aren't they incredible!? Just looking at this picture reminds me that I need to go pick them again, we've had a modest but steady crop from our 3 little bush bean plants. Also, the plants have the most gorgeous purple blossoms, pre-beans.... so they're decorative, and food-making. The best!
I usually use the recipe for "Creamy Hummus" from Vive Le Vegan, but over time I've come to play it by ear. I love how quick and easy and super nutritious hummus is... oh, and delicious too. I eat a lot of hummus, and I never get tired of it.
Both of these big plates o' hummus were created as humungous lunches for yours truly... and I think I managed to put it all away... except there may have been some cucumbers left over from that top plate!
Vegan MoFo:
My plan for VeganMoFo (Vegan Month of Food) is to break the time down into 4 weekly themes... stay tuned for more! To check out all the blogs participating in VeganMoFo this year, click here (over 350 blogs participating this year!!!).
11 comments:
Purple green beans! I don't think I've ever seen those before. Beautiful looking platter!ReplyDelete
I love eating a rainbow of fruits and veggies, it always makes me so happy. And hummus IS the best!ReplyDelete
Love it...looks so delicious!ReplyDelete
I wondered what those purple beans were. Gorgeous!ReplyDelete
Ooh, that looks delicious!ReplyDelete
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The price of oil climbed above $107 a barrel but eased from earlier highs Monday as fears of widening instability in Iraq, a key energy producer, were tempered by views that its oil exports would not be affected for now.
By mid-afternoon in Europe, the benchmark U.S. crude contract for July delivery was up 17 cents to $107.08 in electronic trading on the New York Mercantile Exchange. Earlier Monday, it reached $107.54. On Friday, it added 38 cents, gaining 4.1 percent on the week.
Brent crude, a benchmark for international oils, was up 11 cents to $112.57 a barrel on the ICE Futures exchange in London.
The northern town of Tal Afar became the latest to fall to the militants, who have already captured a vast swath of territory including Iraq's second-largest city, Mosul. The militants vow to march on Baghdad.
The capture of Mosul, a crucial gateway for Iraq's crude, raised worries about whether the country can rebuild its energy infrastructure and boost production to meet global demand, but most of Iraq's oil exports appeared to be beyond the militants' reach.
"Oil production in the south of the country is still secure," said analysts at Commerzbank in Frankfurt in a note to clients, pointing out that around 90 percent of Iraq's oil exports of 2.5 million barrels a day were shipped from there.
"Nonetheless, the threat of civil war in OPEC's second-most-important producer country does justify a risk premium given that the anticipated growth in Iraqi oil production may fail to materialize on account of the unstable security situation and an unwillingness to invest," they added.
A U.S. aircraft carrier has moved into the Persian Gulf as President Barack Obama considers military options, though he has ruled out sending in American troops.
In Europe, Russia cut natural gas shipments to Ukraine due to a payment dispute. Ukraine is also a transit country for Russian energy oil to the rest of Europe, though the dispute was not seen as an immediate threat to supplies.
In other energy futures trading in New York:
— Wholesale gasoline rose 0.24 cent to $3.0258 a gallon.
— Natural gas added 1.6 cents to $4.755 per 1,000 cubic feet.
— Heating oil gained 0.37 cent to $2.9913 a gallon.


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For decades, the Ram was Dodge's iconic full-size pickup. Starting in 2011, however, parent company Chrysler decided to make the Ram name an actual brand. So, yes, this truck's name is now just Ram, with 1500 added on to specify its status as the half-ton truck in the lineup. There are 2500 and 3500 heavy-duty models as well.
Current Ram 1500
The Ram 1500 is a full-size truck offered in three body styles -- regular cab, extended cab ("Quad Cab") and crew cab. The regular cab can be had with either a 6-foot-4-inch bed or an 8-foot version. The extended cab comes only with the 6-foot-4 bed. The Ram's crew cab model provides the most interior room but comes only with a 5-foot-7-inch bed.
There are three trim levels: base ST, midlevel SLT and top-shelf Laramie. The ST is pretty basic, but you still get air-conditioning and a full complement of safety features including stability control, antilock brakes and side curtain airbags. Naturally, moving up to the SLT or Laramie will get you more standard equipment. Notable options include "RamBox" storage bins mounted on the sides of the bed, a TRX off-road package and rear entertainment and navigation systems.
For engines, the Ram 1500 starts out with a 3.7-liter V6 that produces 215 horsepower and 235 pound-feet of torque. A four-speed automatic is standard. The standard engine on the four-wheel-drive Ram ST and all SLT models is a 4.7-liter V8 coupled to a five-speed automatic transmission. Output is a healthy 310 hp and 330 lb-ft of torque. Standard on the Laramie trim and optional on the SLT is a 5.7-liter V8 with a five-speed auto. Output is 390 hp and 407 lb-ft of torque.
In reviews, we've found that this truck excels as a daily-use pickup. A major contributor to this is the truck's coil-spring rear suspension, which significantly enhances ride quality over broken pavement. Another benefit is the roomy and well-appointed interior. The crew cab's rear seat is very comfortable, offering loads of legroom and an agreeable seatback rake. There's also lots of storage space, and the optional RamBox storage bins are pretty cool, though in testing we've found them to be lacking in terms of durability. On the road, the Ram 1500 provides plenty of grunt for towing and hauling when fitted with either V8; the underpowered V6 should be avoided.
Used Ram 1500 Models
The new Ram 1500 name came into being for 2011. In reality, though, it's just the next model year of what was formerly the fourth-generation Dodge Ram. For more information on the Dodge version and its previous generations, please read our Dodge Ram review.
Read the most recent 2019 Ram 1500 review.
If you are looking for older years, visit our used Ram 1500 page.
Our expert team of auto researchers have reviewed the Ram 1500 and compiled a list of inventory for you to shop local listings, and lease a Ram 1500 .


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Stuck duck just part of a town hall tradition in EppingBy JASON SCHREIBER
Union Leader Correspondent
June 04. 2013 10:30PM
EPPING — Lisa Fogg knew something wasn't right Monday when she heard fluttering noises coming from a boarded-up fireplace in her Epping Town Hall office.
"I was a little nervous because I thought if we opened it up, something was going to fly out at us," said Fogg, Epping's town accountant.
After the fluttering continued off and on throughout the day, Fogg asked Town Administrator Gregory Dodge to take a look. They removed the board covering the fireplace, but didn't see anything unusual.
When Fogg returned to work Tuesday morning, she heard the fluttering noises again.
"It was two times right in a row and I heard stuff falling and I thought, 'There's got to be something in there,'" she said.
Fogg then grabbed Road Agent Dave Reinhold, who was at town hall. Reinhold removed the board over the fireplace, poked his head in and looked up the chimney.
He saw feathers and wings and thought it was some kind of bird sitting on eggs in the chimney. But when he grabbed a flashlight and got a closer look, he noticed a big beak.
"It was a big duck. He couldn't open his wings so he couldn't fly," Reinhold said.
Moments later, the stuck duck popped its head down into the fireplace.
At that point, Reinhold put his hands up into the chimney to try to pull the Muscovy duck to safety.
"I had all I could do to get it out of the hole," Reinhold said.
After a few tries, Reinhold was able to free the duck, leaving behind a few feathers. Reinhold held him for a little while, and gave him some water.
"The duck was fine. It was just thirsty," he said.
Reinhold said he took the duck outside to a bridge over the Lamprey River; as soon as he held out his hands, the duck flew off into the water.
This isn't the first time Epping town employees have encountered wildlife in the 19th century brick town hall.
A bat invaded a selectmen's meeting in 2011, swooping around the heads of board members before being shooed off by officials with an umbrella and a table cloth.
In 2009, the town hall was targeted by a flock of pigeons that perched on the bell tower and dumped hundreds of droppings on the walkway below.
For weeks, town employees were forced to power-wash the walkway in the mornings before town hall opened for business.
When Fogg moved into her new office with the old fireplace in April, a small bird somehow made it inside to greet her.
But Tuesday's discovery was a little unexpected.
"I never thought this was going to be a duck," Fogg said.


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Pot proponents hopeful, wary after Obama comments
December 14, 2012
Backers of new laws that legalized marijuana in Washington and Colorado were cautiously optimistic after President Barack Obama said Uncle Sam wouldn't pursue pot users in those states.
Following the November votes in Washington and Colorado the Justice Department reiterated that marijuana remains illegal under federal law, but had been vague about what its specific response would be.
In a Barbara Walters interview airing Friday on ABC, President Barack Obama said: "It does not make sense from a prioritization point of view" to focus on drug use in states where it is now legal.
Marijuana activists were relieved at Obama's comments, but had questions about how regulation will work. They said even if individual users aren't charged with crimes, marijuana producers and sellers could be subject to prosecution, civil forfeiture and other legal roadblocks.


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In the fifth-grade social studies room of Kari Jesse, Painted Stone Elementary students chose what they considered most important and least important in the Bill of Rights. Kendahl Johnson (left) and Katie Rossetti disagreed with other students. They selected trial by jury as among their top five because Kendahl said, "People could get away and commit more crimes, but if they go to a jury they can get punished." Katie said religious rights were No. 1 because "you can't force people to have a religion they don't believe in."
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My area isn't even "slow", it stopped. It goes any slower and it'd be in reverse I think...
I had been wanting to post someting about the current slowdown for a little while, but now it seem things are about to pick back up again with all the new figure sightings.
It seems this "Slow Down" is picking up the pace!i dunno, its probably California but honestly, i thought finding the shock troopers, black pilot or green commander would be difficult, but its NOT.
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text: Tuesday, May 17, 2011 Viewing Anatomical Images Helps Boost Adherence, Says Developer of Virtual Device Microsoft researchers have developed a handheld device that gives physical therapy patients a "virtual view beneath the skin" to see what an injury looks like in the hope that they will be more eager "to keep doing their therapies," says an article in Technology Review. The prototype device comes in 2 parts. The first contains a handheld, or pico, projector, an ordinary digital camera, and an infrared camera. The second contains a laser pointer and the control buttons. Instead of using an autocorrection system to map the image of the internal injury precisely onto the patient's exterior, the physical therapist simply points the projector and lines it up by eye. With the prototype, the images displayed are not actually taken from scans of the patients, but come from stock graphical images used to show 1 of 6 different types of injury. Images also can be projected onto a wall. Even though the images are not of the patient, the technology "appears to be very effective," says Amy Karlson of Microsoft Research's Computational User Experiences Group. Controlled experiments of the device carried out by 2 physical therapists suggest that the device encourages patients to adhere to treatment, the article says. The device is being presented this week in Vancouver at CHI 2011, the Association for Computing Machinery's Conference on Human Factors in Computing Systems. This article features APTA Media Corps member Anne Reicherter, PT, DPT, PhD, OCS, CHES.


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Athenos Greek Strained Nonfat Yogurt in Peach, Blueberry, and Strawberry - If you enjoy dual-compartment fruit 'n dairy combos and 100-calorie snacks, listen up! Athenos (maker of hummus, feta, etc.) has launched a line of Greek yogurt that a) is delicious, b) is fat-free, and c) features plain yogurt packed side-by-side with fruity add-ins! Each 5.3-oz. container has 100 calories, 0g fat, 50mg sodium, 14g carbs, 0g fiber, 9 - 10g sugars, and 11g protein. What a pair! P.S. There's also a with-honey version, but that has higher stats... Jelly Belly Jelly Bean Chocolate Dips - Weeeee! Jelly Belly has taken some of its tasty beans and dunked 'em in dark chocolate! You've gotta taste 'em to believe how good they are. In Coconut, Orange, Raspberry, Strawberry, and Very Cherry, a 40-piece serving of these choco-licious beans has a mere 150 calories, 4g fat, 25mg sodium, 31g carbs, 1g fiber, 20g sugars, and 0g protein. Score! Look for them in stores this month... Manischewitz Ready to Serve Soup, Reduced Sodium Matzo Ball Chicken Soup - Cold weather calls for soup, soup, and more soup. And this new salt-slashed, matzo-ball-packed option from the folks at Manischewitz (love them!) is definitely a must-slurp. Each 1-cup serving has 120 calories and 4.5g fat. We feel better just thinking about it! The new Ready to Serve line also includes Chicken Noodle and Chicken & Rice soups (mmmmm!) with pretty decent stats.
There have been a lot of rumors circulating about Weight Watchers' plans to completely overhaul its famous POINTS® program. Well, the new PointsPlus® program has finally arrived, and we are SUPER-EXCITED! The new plan takes protein and carbs into consideration when calculating a food's value -- not just fat and fiber. Since emerging science establishes that the body processes each of these nutrients differently, the new values will be more effective in terms of weight loss. Some foods have higher values than they did on the old plan, but you get a bigger "points budget" to work with. And -- HUGE news -- just like most veggies, all fruit has a PointsPlus® value of ZERO!!!! (That's right, people. Enjoy those ZERO PointsPlus® value BANANAS. AHHHHHHH!) The plan also emphasizes what it calls Power Foods, stuff that's both filling and healthy. The WW plan is still super-flexible, but it's designed to help you make smarter food choices without even thinking about it. THAT ROCKS. Look for new PointsPlus® values rolling out VERY soon in your HG emails, and consult Weight Watchers for all the details on the new plan. Congrats, WW!
SNEAK-PEEK ALERT! Want to check out some behind-the-scenes footage from the new Hungry Girl TV show? (We're going to assume you said YES!) Click here to see our brand-new video, featuring Lisa (HG herself) on the set of the show, which premieres January 8th at 4pm ET on Cooking Channel! (Click here to make sure you get the channel.) How cool is THAT?! ***A couple of weeks ago, we mentioned a study that found exercise could decrease your risk of getting sick. Heads up! The American College of Sports Medicine is reminding people that intense workouts are NOT recommended if you're already sick. Click here for tips on determining when to work out and when to just stay in bed. Take care of yourself! ***After years of everyone squinting at the teeny-tiny numbers on nutritional labels, the FDA is considering new labeling requirements, like increasing the font size and adding a "percentage of total calories" listing. A study may soon be underway to get consumer feedback on the effectiveness of such changes -- go, FDA, GO! ***Super-caloric holiday drinks like eggnog lattes and caramel apple cappuccinos may be tempting you this time of year, but never fear! Starbucks is test-marketing a 100-calorie Skinny Peppermint Mocha in select markets. Let us know if you encounter one, you lucky beast! ***Those days of standing in front of a vending machine trying to decide what you want are OVER -- that is, if you're in front of one of these new drink-dispensing gizmos... and in Japan. The machines use facial-recognition technology to recommend a drink based on your gender and age -- they even factor in the time of day and temperature outside. Japan, is there ANYTHING you can't do? That's all we've got... HG out!
Your pals NEED this info -- click "Send to a Friend" to keep the information superhighway moving!
Hope you had a great holiday weekend! Today, November 29th, is... National Chocolates Day. Have you tried Gayle's Miracles? Only 30 calories and 1g fat per truffle -- they ROCK!
SmartPoints® value not what you expected? Click here for more info on how the values are calculated, plus more FAQs about PointsPlus® and SmartPoints® values on our website.


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|Hey Mom! Learn more about the Gerber Life Insurance Grow-Up Plan!
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Am I terrible because...
I don't really want a natural birth? I want to want one, but I'd much prefer to go in, get an epi and just sit and relax until it's time to push. I know there can be side effects, I know the reasons natural is better, but I just don't want to go through all that pain. I had a great experience with my epi for my daughter and it makes me want to just do it the easy way again. How do I make myself want a natural birth?
Registered Users
I don't think you are terrible at all! I had an epidural with both of my boys and loved my labors. I would never do it any other way, if I had a choice. I say, go with what you are most comfortable with. Birth is the most personal experience there is and there is no wrong way to bring life into the world.
Happily married, Mom of C (15), M (3), and E (1). Expecting a very big surprise baby on 3/25/14.
WAHM of hand-embroidered creations in my Etsy shop here.
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Formerly: kr***y
Re: Am I terrible because...
But I don't see why you should try to *make* yourself want one.
If you've read all about the pros/cons and risks of epis, and you are comfortable having one, laboring in bed on your back, then do it your way.
That's what informed consent is all about! Knowing the pros/cons and risks associated and making whatever choice fits YOU best.
Know what else? I've had 3 natural pain-med-free births. I am planning my 4th in the next 6 weeks. Sometimes I think to myself, "I wonder what it would be like to just go get an Epi, get hooked up, watch TV for a few hours, maybe take a nap, and then push a baby out of my vag.... be catered to for a few days, brought my meals, get to watch cable, have visitors and flowers delivered to my room....hmmmmmm"
While I believe in natural birth being the best choice, it certainly isn't without its own set of "cons"! Do what works for you, mama. Don't base your decision on what others will think.
Registered Users
Re: Am I terrible because...
If you don't want it you don't want it.
While getting an epidural sounds appealing to me I am more freaked out about it wearing off too early or my body not responding the correct way and me feeling the pain anyways. I know my body has a high tolerance for drugs so I would hate to get the epidural and expect pain relief but get pain anyways. In that situation I would not only be in pain but I would be pissed off! Lol.
My mom went natural with all of her kids. She said it sucks but it isn't the end of the world either. I trust her so my birth wish is to try natural.
Registered Users
Re: Am I terrible because...
I'm in kind of the opposite position. I wish I could talk myself into the epi! It would be so nice in so many ways (I've had 1 epi birth and 4 med-free). But I just have this thing with needles, so I just can't will myself to get one without some stronger reason for needing one.
There is nothing wrong with getting an epi if it is what you want. You absolutely should go with what you are comfortable with.
One option you could consider would be reading up on non-medication coping techniques . When you go into labor, you can use those until you feel ready for the epi. Just an idea :-)
~Amy, Loving wife to E and Happy mama to
K 4/04, L 11/05, E 8/07, V 1/10, J 10/11, and E 5/13
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Re: Am I terrible because...
Not terrible at all. I don't go in with the mindset, "I'm going to get an epidural." and I don't go in with the mindset, "I'm not going to use pain medication." I go in thinking I will roll with the punches and do what feels right. So far, out of my 5 deliveries... I opted for the epidural with 4 of my kiddos. Got the epi, took a nap, woke up and delivered my healthy baby. Every experience was wonderful, and I wouldn't change a thing.
I'm about 6 weeks from having #6, and if I don't need an epi.. great! If I do decide to get one... I have faith all will be well.
I'm Julie. I'm a lucky wife to Micheal and a SUPER blessed mama of 5! Jordyn (12.21.04) Preston (4.10.06) Kyson (6.24.07) Gavin (12.18.08) and Londyn. (4.19.10)
Expecting Emersyn Jewel in March 2013!
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I don't think that makes you terrible at all. I think if you make an informed decision than you shouldn't feel guilty or bad about it. If what you are really looking for is someone to talk you into a natural birth I am sure there are plenty of links and videos and statistics that mamas can direct you to.
I have had a few doulas say that 7cm is a pretty magic number and if you can hold off until then the risks are reduced (no clue if there is any data to back that up), but maybe thats something to look into to help ease your mind?
I will say that you should never count on the labor/birth going a certain way (as I am sure you know). I was all for the epidural with DS. Instead I had problems starting about a half an hour after I got it. It started out spotty and then made my blood pressure crash. Around 7cm they had to turn it off. I was not at all prepared to mentally handle the pain. So my focus with this pregnancy was to prepare for a med free birth just in case.
Registered Users
Re: Am I terrible because...
I think you first have to realize that it doesn't have to hurt. Our bodies are not broken, we are not put on this earth to suffer through childbirth. If you work with your body it really doesn't have to hurt. The US is one of the few (only?) country that believes it hurts this bad. It's all media and old propaganda from when we went from a normal birth at home with midwife society to a hospital society
I've only had one child and there were a few uncomfortable things. It was really hard work. But nothing natural really hurt. (a few things the midwives had to do did!)
I'd recommend taking a HypnoBirthing class (stupid name) it's about letting go, going to your happy place and letting your baby come. At least read the book.
This of course isn't for everyone. If you can't let go of the idea that it's going to hurt like hell, than it is going to and you should do what is best for you.
Mom to LO#1 born 1/7/2010 (Cloth diapered since day 1; Part-time EC since 9 months; Daytime PL since 29 months; Nightime PL at 5.5 years) & LO#2 born 12/1/2013 (First diaper was cloth! Part-time EC since 12 months & Daytime PL at 26 months) Checkout my absorbency tests. Thoughts on how long a cloth diaper REALLY lasts. Thoughts on Yeast , here, here, here & here. How to Wash Wool & Sanitize Wool. Everything must go! Nighttime Trainers
Last edited by Pixi6s; 01-28-2013 at 01:32 PM.
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Re: Am I terrible because...
No way is that terrible... Heck if I every get pregnant I want to just be knocked out and wake me up when its over.
Adoption is my option!Adoptive Mom to Cory (9 years old)
Heartbreakingly long wait to adopt baby 2. (8 years waiting at this point with no end in sight) Please lord..end this wait soon.
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Location: Illinois
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Re: Am I terrible because...
No! It's your birth. You should enjoy and be happy with the birth you have because it's what you want, not because it's what you think you should do.
I'm going into this birth the same way I went into the first which is open mind and see what happens
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The Sixers and Denver are talking about a potential trade that would bring Carmelo Anthony to Philadelphia and send Andre Iguodala to Denver, a Western Conference executive has confirmed to the Daily News.
The executive said Nuggets GM Masai Ujiri has spoken with Ed Stefanski.
Other players would need to be involved in the trade to match salaries.
The Sixers are not among the four teams that Anthony has said are his preferred destinations, with Chicago and New York at the top of his list.
The Sixers also would need to get Anthony to sign an extension. His contract expires after the season and he has not signed a 3-year extension offered by Denver.
Iguodala agreed to a 6-year, $80 million contract with the Sixers in August 2008.
Reports late last week had Anthony close to going to New Jersey in a complex four-team deal that also involved Utah and Charlotte. The New York Daily News is reporting that the Bobcats are holding up the deal, unwilling to include point guard D.J. Augustin. Charlotte was expecting Augustin would replace Raymond Felton, who left this offseason via free agency.
With that deal in peril, the Nuggets have explored other options.
Indications are that the Nuggets would like a deal done before they begin training camp tomorrow.


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He's not your prototypical first baseman, checking in at 5-foot-11, 215 pounds, but he made himself known while playing in the Pioneer League in his debut.
Dickson, who just turned 22 on Feb. 9, posted a .333/.402/.603 triple slash with the Ogden Raptors. His 1.005 OPS was good for fourth in the league and his 13 home runs tied for sixth-best in the league.
His strikeout percentage was a tad high for my liking (23.3 percent), but his walk rate was encouraging (10 percent).
I found a scouting video of him on YouTube. It was posted Sept. 4, 2010, and is courtesy of 49th State Hardball, a website devoted to the Alaska Baseball League. In this league, Dickson played third base. It's too bad he couldn't stick there as the Dodgers system is barren at that position -- and has been for too many years.
As you'll see in the video, Dickson isn't an imposing figure, but he does put a few nice swings on the ball. His stance is wide, his stride is short and he's "quiet" before the pitch. Those are all good things.
Perfect Game, a high school scouting organization and host of showcases around the country, wrote favorably about Dickson in its 2007 analysis.
"The term 'hitterish' comes to mind with Dickson, meaning that he has that certain something that says HITTER."Perfect Game rated him an '8,' which meant Dickson was a potential mid-round selection. It was also all over the place with figuring out where he'd play -- first base, left field, catcher -- but he ultimately ended up at first base.
I ranked Dickson at No. 20 in my Top 50 while Brandon Lennox of True Blue L.A. ranked him at No. 40. He should begin the season in Great Lakes with the Loons.
He's going to have to continue to hit as he progresses if he wants a chance at big league stardom, but I just have a good feeling about this kid -- from everything I've read and seen. Then there's the thing I can't explain -- I can't give you something tangible about his future success, but something just tells me he's going to make it. The proverbial "gut feeling," I suppose.


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I stopped watching the Sunday morning talking head shows a long time ago, mostly because they made me want to throw things at the teevee. And I don't want to hurt the teevee.
But, except for guest appearances by Paul Krugman, I take it the establishment pundit shows have, if anything, grown more insipidly stupid over the years. Watching them may destroy brain cells. See Alex Pareene, "Watching the Sunday Shows So You Don't Have To," and Jason Linkins, "TV Soundoff: Sunday Talking Heads." You can find more intelligence on the Puppy Bowl.
Speaking of insipidly stupid, last week David Brooks got roundly called out by several leftie-leaning media people for writing that President Obama has no plan to avoid the sequester. Jonathan Chait, Ezra Klein, and others let Brooks know this was unvarnished bullshit.
But, as Chait also points out, Brooks isn't the only one saying that Obama doesn't have a plan and that it's his fault if Republicans won't compromise. It seems to be the consensus of the Washington pundit class.
This is all by way of introducing what Steve M wrote about Brooks and his peers:
I didn't join the pile-on because Brooks wasn't engaging in journalism. He wasn't even engaged in fact-based punditry. What Brooks was writing was theology.
Brooks was writing a commentary rooted in the Beltway's political religion. In a religious faith, stories are told that are frameworks for belief, even if they're not believed literally. Thus, when I was a Catholic, I was told that the Bible is the revealed word of God — and yet my faith also accepted the theory of evolution, which tells an origin story for life on Earth that contradicts the one in the Bible. The Church was saying, in effect, that the Genesis narrative of creation is theologically true, even if it's not literally true.
You could say the same thing about the Brooks narrative. It doesn't matter whether President Obama has acted in good faith, despite Republican intransigence, to deal with issues of taxes, spending, debts, and deficits in a responsible way — there are two strains of the Beltway faith, one of which tells us that, on economic issues, Democrats are always wrong and Republicans are always right, the other of which (the one of which Brooks claims to be an adherent) tells us that both parties are to blame, but it's the responsibility of Democrats to move the discussion to a point midway between where the two parties are, which is, by definition, the responsible center. Republicans, according to this faith tradition, will inevitably meet Democrats halfway — though if they don't, that's also the Democrats' fault.
See also Mark Twain, "My First Lie and How I Got Out of It." "Obama has no plan" seems to be a variation of the "silent assertion lie," which are "gigantic mute lies in the interest of tyrannies and shams." It's a lie that becomes an unquestioned orthodoxy because the truth is too terrible to contemplate.


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Stocks soared on the first day of trading in 2013, after Washington lawmakers cut a last-minute deal to avoid automatic tax hikes that threatened to pinch economic growth.
The rally was broad-based, with 10 stocks rising for every one falling on the New York Stock Exchange. All 10 S&P 500 industry sector indexes rose at least 1 percent, led by the S&P information technology index , up 2.2 percent.
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Among the strongest names in the sector was Hewlett-Packard , which rose 5.3 percent to $15 after a miserable 2012 when the stock fell nearly 45 percent.
Congress passed a bill to raise taxes on wealthy individuals and families, and preserve certain benefits, while averting immediate austerity measures. The combination of mandatory tax hikes and reduced federal spending, which had been set to go into effect on January 1, had been known as the "fiscal cliff."
"We had three choices: We were going to be off the cliff, we we're going to be on the cliff, or we were going to avoid the cliff, and we avoided it," said Brian Battle, director of trading at Performance Trust Capital Partners in Chicago.
"There's a relief rally, some progress because we raised revenue, but I think it's going to be short-lived because the relief rally today was created by politics, and the next cliff is going to be created by politics."
The vote avoided tax hikes for all U.S. households, but failed to resolve other political budget showdowns. Spending cuts of $109 billion in military and domestic programs were only delayed for two months, and another fight over the U.S. debt limit looms at that time as well.
U.S. stocks ended 2012 with the S&P 500 up 13.4 percent for the year, as investors largely shrugged off worries about the fiscal cliff.
The Dow Jones industrial average shot up 217.08 points, or 1.66 percent, to 13,321.22. The Standard & Poor's 500 Index rose 23.60 points, or 1.65 percent, to 1,449.79. The Nasdaq Composite Index gained 65.56 points, or 2.17 percent, to 3,085.07.
Bank shares rose following news that U.S. regulators are close to securing another multibillion-dollar settlement with the largest banks to resolve allegations that they unlawfully cut corners when foreclosing on delinquent borrowers.
Bank of America Corp rose 3.5 percent to $12 and Wells Fargo shares added 2 percent to $34.87. JPMorgan Chase & Co shares rose 1.4 percent to $44.28.
Shares of Apple rose 2.3 percent to $544.45, boosting technology stocks, following a report that the most valuable tech company has started testing a new iPhone and a new version of its iOS software.
Shares of Zipcar Inc jumped 48.5 percent to $12.24 after Avis Budget Group Inc said it would buy Zipcar for about $500 million in cash to compete with larger rivals Hertz and Enterprise Holdings Inc. Avis rose 4.9 percent to $20.80.
U.S. manufacturing expanded slightly in December after an unexpected November contraction, an Institute for Supply Management report showed on Wednesday.
A Commerce Department report showed U.S. construction spending fell in November for the first time in eight months, as an extended bout of weakness in the business sector outweighed modest growth in outlays on residential projects.
The stock market's reaction to both reports was muted.
(Editing by Jan Paschal)


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In television, the cancelled show is a common thing. Audience tastes are notoriously hard to predict, so every network is bound to produce its share of losers as well as winners.
However, some shows fall so short of the mark that the network terminates them before all of the existing episodes have aired. Some are pulled due to low ratings, and some because they've created more controversy than anyone bargained for.
But what they all have in common is a network whose higher-ups decided they were better off giving a show an early demise, and hopefully that would allow them to cover their tracks before anybody noticed. A noble goal, to be sure, but unfortunately for them, we noticed.
And so, we bring you 15 shows that were terminated before their time.
By Daniel BukzspanPosted Dec 10 2010


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As it's the 22nd here in the UK, and I've had no new votes, The member with the most votes is..... Drum roll please....
Thomas of Arrowford!
Well done!
The runner up with on 2 less votes was our very own leader... Mark of Falworth!
Congratz guys!
Thomas Arrowford wrote:
So, to the cries of 'Gamble' from the studio audience, I guess I'd better find out what Thomas wants to do with the sword.
...Thomas fully intends to present the sword to the King. However, the best of intentions are easily forgotten when fate forces our hand. Events will transpire which will cause Thomas to use the sword. So, Thomas will be taking the gamble, just not yet...
Let me know the result when you have it, and the die's bidding shall be done.
Buurli wrote:@Mark: When will the next local challenge start?
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Our Space
OurSpace is an online social network where you can express your thoughts and access tools that can increase your say in EU politics.
OurSpace believes the power of European Union's decision-making should be in the hands of young people and that the active involvement of young people in the process of socio-political decision-making plays a very important role in our societies.
Express your thoughts!
Via the OurSpace platform you have the ability to say what you want and be heard by those in charge. Just make your thoughts clear and speak them out! Listen to what other people have to say, challenge them and find solutions for every hot topic in Europe.
You can acess it directly on your computer or via the applications.
Meet the politicians!
OurSpace aims to give you a space to talk, write, share, participate, vote, "allow", propose, and contribute over what is decided for you, without you. And to get ride of the "without" you can have the chance to meet politicians, online and in person, through workshops and conferences. You just have to speak out loud enough for your voice to reach them.
Published: Thu, 03/09/2015 - 10:05
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