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Maria Bamford of "Comedians of Comedy" loves watching "Celebrity Homes" on E! She has a bit where she imagines hosting her own show called "Comedian Homes" in which she would feature the pathetically humble abodes of her standup-scene friends: "This is the kitchen, this is the bathroom, the bedroom—and this is really where the 400 square feet of my apartment is."
If Bamford were interviewing friends who have parlayed their comic talents into blockbuster movies, lucrative TV roles, and best-selling books, however, it would be a different story. These homes owned by comedy stars, provided by Realtor.com, have closets larger than 400 square feet, they have beachfront and bay views, they have invisible edge pools, and spas and guest houses. While many of the following 12 homeowners got their start in standup comedy, most of them are better known for their work on the big and small screens — and one is nominated for a 2012 Oscar.
By Colleen KanePosted 24 January 2012


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Novelty Bakeware
Shape up beautiful cakes, cookies, and other baked treats with these easy-to-use specialty pans and molds. Novelty Bakeware combines great Cake Boss™ quality with molded batter and dough compartments to reduce the guesswork for braided sugar cookies, mini Bundt cakes and more. And there's a wide variety of pans to make distinctive tiered cakelettes from square to groovy flower! Mix it up, pour it in, and let the oven and long-lasting nonstick do the rest.
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subset: commoncrawl


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Stefanie Scott: New York City Girl!
Stefanie Scott is stunning in a short red dress while hanging out on Friday afternoon (December 28) in New York City.
The 15-year-old A.N.T. Farm actress did some sight seeing near Central Park and stopped to feed a carriage horse.
PHOTOS: Check out the latest pics of Stefanie Scott
The day before, Stefanie visited the top of the Empire State Building in the snow and went to see Annie on Broadway.
"Wow @ANNIEonBroadway is so good! And @LILLACRAWFORD is so adorable and talented! #youreneverfilludressedwithoutasmile!" Stefanie tweeted after the show.
15+ pictures inside…
Posted to: Celebrity Pets, Stefanie Scott


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CAIRO (AP) — A senior Egyptian police officer was killed by a bomb placed under his car in a western Cairo suburb Wednesday, the latest in a series of targeted attacks on police and the military as Islamic militant groups keep up a campaign of violence since last summer's ouster of Islamist President Mohammed Morsi.
Brig. Gen. Ahmed Zaki was the second police officer of that rank killed this month in a bombing, a sign of how the violence has shifted from high-profile suicide and car bombings against police installations toward more low-level attacks on individual officers or small police posts.
Also Wednesday, a police lieutenant was killed in a gun battle that erupted as security forces raided a militant hideout near the Mediterranean coastal city of Alexandria.
Al-Qaida-inspired militant groups have claimed responsibility for most of the attacks. The groups have said their bombings and shootings are to avenge the fierce crackdown on Morsi's Islamist supporters in which more than 1,300 people have been killed and thousands arrested. The government says suspected militants have killed more than 450 policemen and soldiers since July.
The government accuses Morsi's Muslim Brotherhood of orchestrating the violence, saying it is ultimately behind the militant groups. It declared the group a terrorist organization late last year. The Brotherhood denies the claim, saying the terror brand aims to justify wiping it out as a political force.
There was no immediate claim of responsibility for Wednesday's killing, but the Interior Ministry blamed the Brotherhood.
"The Egyptian police continue its determined and decisive confrontation in its battle against terrorism," ministry spokesman Hani Abdel-Latif said in a televised statement. The police "will continue their efforts to face up to these terrorist operations that are plotted by the terrorist Muslim Brotherhood group."
Zaki was heading to work early Wednesday from his home in the Cairo suburb of 6th of October when the bomb detonated under the police car assigned to transport him, critically wounding him. He later died in hospital, Abdel-Latif said. Two conscripts were wounded.
Zaki is one of the most senior officers to be killed in the campaign of violence. He was in the leadership of the Central Security Forces, the riot police branch that takes the lead role in dealing with protests and general security.
A senior security official in Cairo said Zaki had sat through planning meetings for the Aug. 14 operation that broke up two pro-Morsi sit-ins in the capital, in which security forces killed more than 600 protesters. The official spoke on condition of anonymity because he was not authorized to talk to journalists.
Speaking to The Associated Press, Abdel-Latif said he was not aware of what Zaki's tasks included, but dismissed the possibility he was targeted for any specific role he played.
"They are targeting police force wherever they are," he said. "They make a homemade bomb and toss it at police."
He pointed out that traffic police have also been hit and that recently even a civilian wearing a police-style beret had a bomb lobbed at his vehicle.
Another brigadier general was killed on April 2 when three bombs were placed by a riot police post outside Cairo University, where protests by largely Morsi supporters have been regular and often bloody since the start of academic year in September.
A new group that first appeared in January, Ajnad Misr, or "Egypt's Soldiers," claimed responsibility for that bombing. In a statement, it said it was waging a campaign of retribution and that the slain police general had been involved in killings of protesters. It said the attack also came in response to increased detentions of female protesters.
On Wednesday, new clashes between security forces and students broke out near or outside universities following protests in Cairo and in the cities of Fayoum and Assiut, as well as others. One student was injured in Fayoum by birdshot, while police also fired tear gas in the clashes.
In Alexandria, Lt. Ahmed Saad was shot and killed during a raid on a militant hideout. Militants opened fire on the police as they moved on the hideout in a farm area in Borg al-Arab, a western district on the Alexandria's outskirts, the city's police chief Police Maj. Gen. Amin Ezzedin told the state news agency MENA. He said one suspect was also killed and another arrested.
Abdel-Latif said two suspects were arrested and are believed to be members of Ansar Beit al-Maqdis, one of Egypt's main militant groups. Abdel-Latif said the cell was planning attacks on security forces.


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Deutsche Bank down on possible profit warning: WSJ
(3:28 PM ET) NEW YORK (MarketWatch) -- Shares of Deutsche Bank AG DB, -0.61% (XE:DBK)fell 3.5% Friday afternoon after The Wall Street Journal reported the bank is weighing whether to issue a profit warning, citing people familiar with the matter. The potential warning would focus on Deutsche Bank's losses from selling unwanted assets in the fourth quarter, which were larger than expected, the WSJ said. The German bank is scheduled to report 2013 earnings on Jan. 29, and German law requires public companies to warn investors if it becomes clear that results will miss market expectations significantly and move shares.
Morgan Stanley pledges higher dividends, buybacks
(12:27 PM ET) NEW YORK (MarketWatch) - Morgan Stanley MS, -2.00% on Friday pledged to increase shareholder dividends and stock buybacks in a bid to return cash to investors, but the bank stopped short of giving many details. In a note issued with fourth-quarter results, Morgan Stanley promised a "steady increase" in share buybacks "in the coming years," and that it would "begin increasing (the) dividend reflecting stable earnings streams." Big banks last week submitted capital plans to the Federal Reserve, which will decide whether to grant them permission to buy back their own stocks or pay out higher dividends to shareholders. Last year, in the initial submissions, Morgan Stanley did not ask for permission for either; instead it asked only for approval to buy out the rest of Morgan Stanley Smith Barney, the retail brokerage it jointly owned with Citigroup Inc. C, -3.30% The bank finished buying the rest of Morgan Stanley Smith Barney shortly afterward, and then asked for - and received - approval for a share buyback, its first since 2008. It is currently paying a quarterly dividend of $0.05 per share.
Morgan Stanley shares leap 4% on strategic plan
(9:58 AM ET) NEW YORK (MarketWatch) -- Morgan Stanley MS, -2.00% shares leaped 4% Friday morning, with investors encouraged by the bank's updated strategic plan. The gain came even as the bank reported, which were crimped as the bank set aside more money for potential legal expenses. In the strategic plan, Morgan Stanley reiterated its goal to get the return on equity above 10%, excluding an accounting charge. That would be roughly double its current level. It also raised its goal for profit margins in the wealth management unit, which it has been emphasizing in a bid to make returns steadier and less risky, and. It also sketched out plans to potentially. The bank added that it had made faster-than-expected progress on scaling back certain assets in its fixed income and commodities unit, where revenue has been under pressure from new regulations and a fizzling market. The bank also laid out goals for reaching new capital requirements from regulators.
GE shares turn lower as investors await call
(8:44 AM ET) CHICAGO (MarketWatch) -- GE shares GE, -0.32% have turned lower in premarket trades as investors get their first look at collateral materialsposted onlinein advance of the company's upcoming earnings conference call. Those materials reportedly detail a lower level of GE Capital dividend payouts in 2014, a plan to reduce structural costs by $1 billion and a forecast of as much as $1.5 billion in restructuring expenses. Earlier GE had saidwere up from a year ago and its backlog was at a record level. Shares were down 2.4% some 50 minutes before the opening bell on the New York Stock Exchange.
Morgan Stanley eyes sale of pipeline operator
(7:59 AM ET) NEW YORK (MarketWatch) - Morgan Stanley MS, -2.00% said Friday it is looking at "strategic solutions" for its commodities business, including the potential sale of the TransMontaigne pipeline operator. In a note released with fourth-quarter results, Morgan Stanley said it was pursuing "strategic options" for TransMontaigne, whose physical assets are concentrated in the Southeast, Midwest and along the Mississippi and Ohio rivers. The announcement comes as regulators scrutinize banks' holdings of physical commodities like metals and oil, amid concerns that the banks have been unfairly driving up prices. In December, Morgan Stanley announced it would sell its division that stores, trades and moves physical oil to Russia's Rosneft Oil Company, a sale that it expects to close in the second half of this year. Overall, revenue for the unit that trades fixed income and commodities fell 14% in the fourth quarter, though that was an improvement from the 44% drop in the third quarter. Morgan Stanley also said it planned "centralized decision making" for fixed income. It also said it had made quicker progress than expected in trimming the fixed income and commodities unit.
GE earnings, revenue rises, posts record backlog
(6:48 AM ET) MADRID (MarketWatch) -- General Electric Co. GE, -0.32% on Friday reported higher earnings and revenue amid strong orders and a record backlog for the fourth quarter. The company reported operating earnings of $5.4 billion for the period, or 53 cents, a gain of 20% from the same period a year earlier. Revenue rose 3% to $40.38 billion in the fourth quarter, a gain of 3% from the year-ago period. Analysts polled by FactSet Research were forecasting earnings per share of 53 cents on revenue of $40.27 billion. The company said infrastructure orders for the period were $30.7 billion, a rise of 8% and the backlog of equipment and services at the end of the quarter was at a record $244 billion. Industrial-segment margins improved 100 basis points over the prior-year period. Growth-market revenues were up 10% for the period, with double-digit growth in six of nine growth regions.
Royal Dutch Shell warns over profit
(3:01 AM ET) MADRID (MarketWatch) -- Royal Dutch Shell Group PLC RDS.A, -3.08% (UK:RDSA)warned Friday of "significantly lower" fourth-quarter profit due to weak industry conditions for downstream oil products, higher exploration costs and lower upstream volumes. Shell projected earnings on a current cost-of-supplies basis, excluding identified items, of around $2.9 billion for the period. "Our 2013 performance was not what I expected," said Ben van Beurden, chief executive officer of Shell, in a statement. "Our focus will be on improving Shell's financial results, achieving better capital efficiency and on continuing to strengthen our operational performance and project delivery." Shell is due to announce results Jan. 30, and also projects fourth-quarter 2013 earnings of $2.2 billion, and full-year 2013 CCS earnings of $16.8 billion.


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Netsuke in form of women giving birth
This small wooden netsuke shows a woman assisting another woman in labour. The head of the baby is visible. Until recently, women were traditionally the main birthing assistants across all cultures. They often had little formal medical training. Women are still the main birthing assistants in much of the world today. Netsuke are toggle-like ornaments. They hang objects such as medicine boxes or tobacco pouches from the sash of a kimono - a traditional Japanese dress. Netsuke are usually made from wood and ivory and are highly collectable.
Object number:
Related Themes and Topics
Related Objects
There are 631 related objects. View all related objects
Glossary: obstetrics
A branch of medicine dealing with the care of women. This care occurs during pregnancy, childbirth, and the period of recovery from childbirth.
Glossary: netsuke
Small ornamental object carved in wood or ivory. Netsuke were used as toggles (buttons) for Japanese kimonos or pouches in the 1600s.


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Run/Walk registration is now open
Registration is now open for the 20th Annual Pueblo to Pueblo Run/Bike Event, which will take place on April 26.
This year's event features a half marathon run, a 5k run/walk and a 50-mile bike event.
To register, visit the Cortez Cultural Center's website at www.cortezculturalcenter.org or contact the Center at 970-565-1151.
Super Saturday softball registration now open
Southwest Softball will be hosting their annual Super Saturday registration at Hibbetts Sports on March 22 from 11 a.m. until 3 p.m. Contact Kelli Unrien at 970-394-0050 with questions.
City accepting registrations for three-on-three volleyball
The City of Cortez is now accepting registrations for men's and women's three-on-three volleyball. Entry fees are $75 per team, and games begin on April 14. For more information, contact Joye McHenry at 970-564-4083.
Journal Staff


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Updated 10:04 PM ET
CARACAS, Venezuela Venezuelan President Hugo Chavez is undergoing "extremely complex and tough treatments" following cancer surgery, his vice president said Wednesday.
It was the first time that the government described Chavez's treatment following his surgery in those terms. The government has not given details about what sort of treatment Chavez is now undergoing in Havana, more than two months after his fourth cancer-related surgery on Dec. 11.
"They're complex treatments... that should at some point begin to close the cycle of treatment for his illness," Vice President Nicolas Maduro said on television, without giving details.
Maduro spoke after returning on Wednesday from a trip to Cuba, where Chavez continues to receive medical care. Maduro said he had met with the president's doctors and relatives. He said that the president's elder brother, Adan, had also returned from Cuba to Venezuela on Wednesday.
Chavez hasn't been seen or spoken publicly since Dec. 10, when he traveled to Havana for the operation.
Venezuelans on both sides of the country's political divide have been speculating about the socialist leader's condition amid vague reports about his health.
Information Minister Ernesto Villegas had said on Jan. 26 that during the surgery a "malignant lesion" was removed from Chavez's pelvis and that his recovery has been favorable. Villegas also said that Chavez had begun "systemic medical treatment for the fundamental illness."
Medical experts consulted by The Associated Press have said the government's account of "systemic medical treatment" could mean various types of chemotherapy or drug treatments, depending on the type of cancer.
Chavez has had tumors repeatedly removed from his pelvic region, and has also undergone prior rounds of chemotherapy and radiation treatment. The 58-year-old president hasn't revealed the type of the cancer or the precise location of the tumors removed.


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In this beautifully mounted historical drama, Angelo Pardi (Olivier Martinez), an Italian soldier, is fleeing his country in 1832. After the fall of Napoleon, Austria is swooping down on Italy to take control of the nation, and like many patriots, Pardi is hoping to escape to France and fight for their freedom abroad rather than submit to Austrian rule. However, as Pardi discovers upon arival, an epidemic of cholera is sweeping the land, leaving death in its wake and causing most people to be fearful of strangers, who may well be infected. As he tries to outrun a trio of mercenaries who have been hired to take him back to Italy, he finds himself accused by a group of villagers of infecting their water supply. Trying to escape would-be captors on all sides and searching for refuge in a rainstorm, Pardi finds a house and takes shelter inside. Unknown to Pardi, Pauline (Juliette Binoche), the lady of the house, is at home, but to his pleasant surprise, she welcomes him cordially rather than sending him away. It seems that Pauline's husband is missing, and as she desperately wants to find him and Pardi needs to escape to friendlier circumstances, they travel together through the French countryside, hoping to avoid both the disease and the tragedy travelling in its wake. Reportedly the most expensive French production ever made at the time of its release, Le Hussard Sur Le Toit (released in the United States as The Horseman on the Roof) was nominated for ten Cesar Awards (the French Oscar); it won two, for Best Cinematography and Best Sound. ~ Mark Deming, Rovi
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
Copyright © 2018 FANDANGO MOVIES.


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Did you know?
The city of Portland was officially incorporated on February 8, 1851. — www.travelportland.com
We impress upon you the importance of fulfilling AAPT's financial obligations to the Hilton Portland and Executive Towers. We appreciate everyone's support in booking within the official AAPT hotel blocks. Learn more about helping AAPT avoid attrition fees. Be sure and mention the AAPT room block to secure the group rate.
Conference Hotel: Hilton Portland and Executive Tower
Room and Ride Share, and Daycare Information & Registration
If you are interested in sharing a room, ride or daycare responsibilities at the Portland meeting, AAPT provides this free, online registration that allows you to find a ride, room or daycare experience with other attendees. Save on gas and money!
Hilton Portland and Executive Tower
Reservation Information
To make a reservation call 1-800-HILTONS (1-800-445-8667) and ask for the American Association of Physics Teachers room block or use the code PHT. Click here to make a reservation online.
Participants are responsible for their parking charges
Paramount Hotel
The Paramount Hotel has a small block of rooms set aside at $184 +14.5% Multnomah County Lodging Tax. Call 1-855-215-0160 (toll free) and ask for American Association of Physics Teachers rate to reserve by June 17th.
Paramount Hotel
Details: Well-appointed high-rise hotel, one block away from the Hilton Portland & Executive Tower. Wi-Fi/Internet included. Next to Director's Park, the MAX, the Portland Food Cart Culture, Fox Tower Cinemas, Arlene Schnitzer Concert Hall & Park Blocks. Tasting East restaurant is on-site.
Find out more and become a part of SM2013 on: Facebook| Twitter
Some photos courtesy of travelportland.com


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Did you know?
Jacksonville is the largest city in Florida and the thirteenth most populous city in the United States — Wikipedia.org
2011 Winter Meeting in Jacksonville, Florida. January 8-12, 2011
2011 AAPT Winter Meeting Highlights
The 2011 Winter Meeting in Jacksonville, Florida was a great success. The meeting was atteded by physics educators and students from 15 countries outside of the United States: Brazil, Canada, Denmark, Ecuador, Ethiopia, Greece, Iran, Italy, Korea, Mexico, Netherlands, Norway, Sweden, Switzerland, United Kingdom. Thanks to all that particpated.
Streaming Video
AAPT captured all plenaries and award presentations at the 2011 Winter meeting via streaming video. To view please go to http://www.ustream.tv/user/physicsteachers or see the links below.
Plenary Speakers and Award Winners
Special Event


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Infinova's Universal Security
Your advantage in the analog-digital transition Hybrid, multi-site, and multi-functional platform for transmission, switching and storage of video (analog or digital), audio, data, Gb Ethernet, alarm, and intercom; 40 Gb internal bus, 2.5 Gb fiber optic backbone up to 1024x1024 fully switchable videos per site; integration with Infinova products including NVR/VMS. Infinova is an innovative manufacture of complete system solution products at competitive prices backed with first-class services.
Visit www.infinova.com
ASIS Booth No. 1055
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Prostate Cancer Canada is the leading national foundation dedicated to the elimination of the disease through research, advocacy, education, support and awareness.
Learn more about the PSA test, its advantages, and limitations. #KnowYourNumber
Prostate Cancer Canada is pleased be contributing to innovative advancements in prostate cancer research.
Just found out you have prostate cancer? Looking for information? Wondering what programs and resources are available to you? Help is here.
Wake Up Call Breakfast is a unique opportunity to support the 1 in 7 Canadian men who will be diagnosed with prostate cancer in their lifetime. It brings together business leaders in an event tailor made for them, to raise awareness and funds for the most common cancer affecting Canadian men.
Your donation helps protect men and their families from prostate cancer. You'll be supporting the most promising research projects, and providing men with care and support when they need it most.
Why is it
Should I
get tested?
Vancouver, September 25, 2018 – Research funded by Prostate Cancer Canada is preparing the way to improve quality of life for men-who-have-sex-with-men (MSM)1 in the LGBTQ2+ community.
Toronto, June 27, 2018 – Canadian researchers are leading the future of treatment for men with advanced prostate cancer in this country, with a new Prostate Cancer Canada grant funded by the Movember Foundation.
TORONTO, CANADA (May 8, 2018) – Every day, more and more methods to detect prostate cancer are being explored, but the tried and true methods of a digital rectal examination (DRE) – where a healthcare professional inserts a gloved finger into the rectum to check for abnormalities, paired with a blood test known as the prostate-specific antigen (PSA) test – which you can get through your family doctor, are still the long-standing proven ways to save a life.
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Telephone: 416-441-2131
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Please note we cannot provide medical advice or endorse specific services, products, treatments or medical centres.


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It is possible that the main title of the report Twin-Twin Transfusion Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Twin-twin transfusion syndrome (TTTS) is a rare disorder that sometimes occurs when women are pregnant with identical (monozygotic) twins. It is a rare disease of the placenta, the organ that joins the mother to her offspring and provides nourishment to the developing fetuses. During the development of identical twins, there are always blood vessels in the fetuses' shared placenta that connect their blood circulations (placental anastomoses). In most cases, the blood flows properly through these vessels. However, in twin-twin transfusion syndrome, the blood begins to flow unevenly, with one fetal twin receiving too much blood (recipient) and one receiving too little (donor). The recipient twin may experience heart failure due to continual strain on its heart and blood vessels (cardiovascular system). The donor twin, on the other hand, may experience life-threatening anemia, insufficient nutrition and oxygen due to its inadequate supply of blood. Such an imbalance in blood flow (i.e., twin-twin transfusion) can occur at any time during the pregnancy, including during delivery.
The effects of twin-twin transfusion syndrome can vary in severity from case to case, depending upon when during pregnancy the syndrome occurs, when it is diagnosed, and any treatment that may be given. The cause of this syndrome is not fully understood, although it is known that placental characteristics play an important role.
Twin to Twin Transfusion Syndrome Foundation
National Office
411 Longbeach Parkway
Bay Village, OH 44140
Tel: (440)899-8887
Tel: (800)815-9211
Email: firstname.lastname@example.com
Internet: http://www.tttsfoundation.org
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
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Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
Email: http://rarediseases.info.nih.gov/GARD/EmailForm.aspx
Internet: http://rarediseases.info.nih.gov/GARD
Fetal Hope Foundation
9786 S Holland Street
Littleton, CO 80127
Tel: (303)932-0553
Tel: (877)789-4673
Email: email@example.com
Internet: http://www.fetalhope.org
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 9/4/2008
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|FreeBSD General Other questions regarding FreeBSD which do not fit in any of the categories below.
|Thread Tools
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FreeBSD amd64 arch Cpu type
I couldn't help but learn that people from the bsdforums are moving here, so I'll re-post my question.
I have an Intel Core 2 Quad Q6600 CPU and was wondering if there was a better cpu type than "Hammer" to use for this processor? Is it even possible to choose others for this arch? I figured that was probably the best target, (hence, the default for amd64), and it seems to detect my CPU's features correctly but is there something I could choose that's more optimal? I configured and built my kernel and it seems to run just fine but there's always that nagging doubt that I could have used something better
The NOTES only shows HAMMER
I thought I'd look through some of the cpu related stuff under /usr/src/sys/amd64 and found this. (cputypes.h)
/* * Classes of processor. */ #define CPUCLASS_X86 0 /* X86 */ #define CPUCLASS_K8 1 /* K8 AMD64 class */ /* * Kinds of processor. */ #define CPU_X86 0 /* Intel */ #define CPU_CLAWHAMMER 1 /* AMD Clawhammer */ #define CPU_SLEDGEHAMMER 2 /* AMD Sledgehammer */
This is what I get from dmesg (looks ok to me... detected as a K8-class)
CPU: Intel(R) Core(TM)2 Quad CPU Q6600 @ 2.40GHz (2400.01-MHz K8-class CPU) Origin = "GenuineIntel" Id = 0x6fb Stepping = 11 Features=0xbfebfbff<FPU,VME,DE,PSE,TSC,MSR,PAE,MCE,CX8,APIC,SEP,MTRR,PGE,MCA,CMOV,PAT,PSE36,CLFLUSH,DTS,ACPI,MMX,FXSR,SSE,SSE2,SS,HTT,TM,PBE> Features2=0xe3bd<SSE3,RSVD2,MON,DS_CPL,VMX,EST,TM2,SSSE3,CX16,xTPR,PDCM> AMD Features=0x20100800<SYSCALL,NX,LM> AMD Features2=0x1<LAHF> Cores per package: 4
The Intel Core two Duo processors are considered as members of the x86_64 processor family, which fiI am not the least bit wrong means that the iso images you used to burn your installation media wern't he correct ones.
Google Linux is a Green Horns Best Friend (GHBF).
Windows = a 32 bit extensions to a 16 bit patch to an 8 bit operating system originally coded for a four bit processor written by 2-bit monopolistic software company founded by a .3-bit Harvard Drop out, who can't stand one respectable bit of competition.
If I believe something to be immoral a will not keep quite and let my voice of annoyance be heard loud and clear.
Thanks for the reply, but that's not true. "amd64" refers to the arch and is generally synonymous with x86_64 (in fact x86_64 is the arch according to the compiler) The other 64 bit download option, ia64, is a completely different arch for Itanium-like processors. That would definitely not run.
Hence, in the kernel config, the correct cpu entry to use is HAMMER, for all 64-bit x86 CPUs.
Thanks, that confirms much of what I thought. I just didn't know for sure if there were other CPU types available. (Note that I'm coming from Linux where there are individual definitions for various processors. It's still much the same though, the kernel will still detect the CPU's features properly and will still run on a compatible one, though perhaps not optimally)
This is a Hell of a nice setup.
Does this mean that the AMD Atlon X2 Duel Core 5600+ processor in my Pavillion a6230n Desktop Is acyurally not based uopon a true sixty-four bit Processor, but instead A 32 bit chip masquerading as a 6bit chip
Google Linux is a Green Horns Best Friend (GHBF).
Windows = a 32 bit extensions to a 16 bit patch to an 8 bit operating system originally coded for a four bit processor written by 2-bit monopolistic software company founded by a .3-bit Harvard Drop out, who can't stand one respectable bit of competition.
If I believe something to be immoral a will not keep quite and let my voice of annoyance be heard loud and clear.
Last edited by FloridaBSD; 26th May 2008 at 04:53 AM.
Essentially correct, the x86_64 chips (AMD64 and later copied by Intel who calls it EM64T) are really x86 processors with 64 bit extensions (additional registers and stuff activated by a 64 bit operating system kernel). They can run both 32 bit and 64 bit code natively. That doesn't mean anything inferior... it's the best of both worlds. Intel's idea of IA64 didn't really catch on, it was too incompatible. Microsoft thumbed their noses at it because too much of their rubbish would have had to be rewritten from the ground up lol
You can set the exact CPU type in the machine via /etc/make.conf and that will enable different features in the software you install via the ports tree or when compiling the world or kernel. See /usr/share/examples/etc/make.conf for all the details. This sets all the gcc options like -m -cpu and so forth.
If you install a 32-bit OS on your amd64 CPU, you get a souped-up 32-bit CPU.
If you install a 64-bit OS on your amd64 CPU, you get a 64-bit CPU, with all the advanced features that come with it.
For kernel:
COPTFLAGS=-O2 -march=nocona
That's safe enough, because the kernel build system turns off potentially harmful instructions (e.g. -mno-sse2 -mno-sse3 -mno-mmx etc.) that would be enabled by -march.
That's just optimizing the execution of the kernel functions themselves though.
For general software:
CFLAGS=-O2 -mtune=nocona
That's safe enough to enable globally. -mtune just tunes the scheduling and stuff for the specified cpu and doesn't break anything.
nocona is about the closest thing to correct that gcc 4.2.x will do for my CPU. Once gcc 4.3.x is a bit more mature and usable (and projects catch up with it), there's a core2 cpu type.
Don't do that. Leave CFLAGS alone. You have removed a whole list of defaults that may lead to breakage down the line.
Set CPUTYPE in /etc/make.conf and let the make system fill in the rest based on that. CPUTYPE sets -march, -mtune, and a bunch of others.
Hmm, OK, thanks. I'll stop doing that (Been doing CFLAGS in make.conf since FreeBSD 5 though). I would have thought it just appended to the compile commands. I've never done a build world though, but it's never caused me a problem with any of the ports that I use.
I wouldn't want to do CPUTYPE=nocona though, because that will blindly enable things like SSE2 and SSE3 etc. which does break builds, or worse, subtly breaks the results. CPUTYPE seems to do -march
CPUTYPE sets various flags for port and world compiles. It doesn't enable things like SSE for kernel compiles, though. The build system is smart enough to know what is safe for the kernel and what is safe for the world.
Until you set CFLAGS, that is. Then things can go haywire. If you use CFLAGS=whatever, then you are replacing the CFLAGS set in the build system. If you use CFLAGS+=whatever, then you append to the end of the CFLAGS line, again overriding anything set previously. If you use CFLAGS="whatever ${CFLAGS}" then you add your option in front of the defaults, and the defaults override your settings. Things can get pretty hairy.
And the default CFLAGS do change overtime (for instance, -O2 is the default now).
Better to set CPUTYPE, don't set CFLAGS, and just let the build system do its job.
Yep, I agree there's no problem with using -march for the kernel (as stated, the kernel build system disables such instructions with with -mno in every compile command, including the modules that get built for everything you disable in the main kernel image) but that's not the case with ports.
In my sillier days, I used to do -march=pentium4 for everything I compiled in Linux until I learned that SSE2 subtly breaks stuff. It's not something you can put your finger on either. One time I had a problem with certain gtk+ dialogs intermitently crashing the X server. Some chooser dialogs, Gimp options, the file manager in XFCE. The cause was GTK+ being compiled with -march=pentium4, specifically the use of SSE2. That caused me a lot of aggravation. I was attacking the problem as if it was something to do with X. As if it was something to do with the Radeon driver. Everything but Grogan and his stupid compile flags :-)
I've also subtly broken some functions in programs that way too. The rest of the program works fine, except for a few features.
That said, I decided to do it anyway lol
CPUTYPE=nocona in make.conf. If anything breaks, I'll fix it and not do it anymore. I just want to see for myself how things have progressed. Things may not miscompile anymore, gcc is smarter than it used to be now too.
I took out the other stuff.
I wanted to rebuild my kernel again tonight anyways, to try that SCHED_ULE which is purported to be a better scheduler for SMP. So far it's doing quite well (watching top while the system is under stress) and staying snappy.
Last edited by Grogan; 7th May 2008 at 06:55 AM.
GROGAN I have only broken ports when using the -jx option. My system has never run better since specifying CPUTYPE in make.conf
Thanks guys, coincidently I just did a buildworld tonight, with CPUTYPE=nocona and it passed -march in the compile commands. So far, everything seems to be good.
First time I did one and it wasn't a big job at all. It didn't even take an hour, even without -j. (I chickened out on that because it said to avoid using it in the notes). Next time I'll try -j5.
It'll be good if they ever make ports parallel build safe... it's a drag when you're waiting on stuff to finish. (though there's nothing stopping me from doing other non-ports build jobs at the same time)
Well, even though ports doesn't support -j, there's nothing stopping me from getting work done. I've been redoing KDE from ports tonight, and after I got libs and base and stuff down, I've been building 3 ports at the same time to get all the rest of the KDE components done. And still plenty of CPU cycles free for surfing the web and listening to tunes and stuff at the same time :-)
I was worried that maybe some environment variables would collide or something, but since they are separate virtual terminals (rxvt) that can't really happen.
Really good scheduling here... I can hardly tell I'm compiling. I think this is where FreeBSD kicks ass.
Can i use CPUTYPE Athlon or Athlon-xp, as i´m having duron 1800Mhz applebred?
Some say that the only difference between athlon and that duron is cache...
If i can´t, what should i use?
I think that the only CPUTYPE for amd64 at the moment is athlon64.
OH, and please don't threadjack. If you have a question, ask it with a new thread (after searching, of course). Please do not simply tack it onto the end of someone else's thread.
Doubly important if the thread does not apply to your CPU - that is not a 64 bit cpu!!!
A slightly older /usr/share/examples/etc/make.conf lists these as the CPUTYPES for AMD CPUs
# (AMD CPUs) opteron athlon64 athlon-mp athlon-xp athlon-4 # athlon-tbird athlon k8 k6-3 k6-2 k6 k5
The only dumb question is a question not asked.
The only dumb answer is an answer not given.
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text:
TheAncientOne wrote:
Even when you account for Japan's population being only 41% of the U.S., I think you'll have a difficult time coming up with an OVA in the past 5 years that sold over 66,195 copies (41% of the lowest selling title on that list), much less 280,510 (41% of the highest).
The fifth volume of Gundam Unicorn (released last week) sold 145,449 copies in it's first week of sales.
llamaben wrote:
The fifth volume of Gundam Unicorn (released last week) sold 145,449 copies in it's first week of sales.
The numbers I was using didn't include BD sales. Here is an example of how that might affect the numbers:
Among the three new DC Universe Animated Original Movie titles, the July 2010 Batman: Under the Red Hood animated feature made the biggest splash of this years releases, moving 510,000 DVD units and nearly 275,000 Blu-ray units since hitting shelves. Home video retail outlets are expecting the title to finish with at least 800,000 of combined units sold by the end of 2010. The direct-to-video Batman: Under the Red Hood animated feature debuted to 140,000 DVD copies sold in its first week of sales, during the week ending August 1st, 2010.
Keep in mind it was #3 on that list.
No luck finding how the #1 title fared on BD, but I did find this interesting tidbit on the DVD. Sales actually rose from week 1 to week 2 (big jump), and then again to week 3. Don't most anime peak their first week out?
I did find a message in this forum that gave the first week sales for a number of titles. The lowest ranked title (Batman: Year One) from my earlier list shows first week sales of 65,000 for DVD and 102,000 for Blu-ray. Based on the combined total of 167,000 for first week sales alone, 41% would be 68,470. This apparently beats the first week sales for Madoka Magica (62,041 per this site), which itself broke a record set by Bakemonogatari. I note the following week numbers for show a very steep drop off, following the pattern I expected for anime.
The DC DVD + BD First Week Sales List:
Spoiler Alert! Click to show or hide
Superman - Doomsday // 288,236 // //
Justice League - The New Frontier // 136,000 // //
Batman: Gotham Knight // 230,000 // //
Wonder Woman // 107,000 // 17,000 // 124,000
Green Lantern: First Flight // 158,250 // 34,000 // 192,250
Superman / Batman: Public Enemies // 197,629 // //
Justice League: Crisis on Two Earths // 205,000 // 60,000// 265,000
Batman: Under the Red Hood // 140,000 // 115,000 // 255,000
Superman / Batman Apocalypse // 155,000 // 95,000 // 250,000
Superman / Shazam // ~64,500 // ~30,000 // 94,500
All-Star Superman // 122,000 // 65,000 // 187,000
Green Lantern: Emerald Knights // 101,000 // 129,000 // 230,000
Batman: Year One // 65,000 // 102,000 // 167,000
Yes, that's my real age
visoredavenger wrote:
Mertonan wrote:
The real problem is you assume the average Japanese person cares about American animation.
They don't. American animation does terrible in Japan and not noteworthy
So you are saying American animation is a niche market in Japan since they bother to dub it in the first place means enough people are watching it to make it profitable.
Just like Anime is a niche market in the West since stuff like King of the Hill blows away anime.
The average American doesn't care about anime either ,and yet a bit of this niche market rages out of control over dubs.
Yup, it also seems like they are trying to make excuses for Japan, seeing as anime here, is the same as anime (note: all of it is called anime in Japan) from the US in Japan...>.>
As for the actual topic, yes, there are probably purists there too, just like we have here, though they probably aren't as annoying as the people here who go on and on about it
sames goes with animes with English dubs so, everything's even imo <<;;
Dulce, Mimmy. Create one more stupidity here and I'll hate you 2. I'm serious.
http://www.siliconera.com/2010/02/22/subs-or-dubs-which-does-japan-prefer-for-western-games/. In this, the only categories that the Japanese preferred subbed were RPG and Xbox 360. In those, I find it fair to assume that some of those games have the cartoon-style graphics. Of course, cartoons aren't limited to TV or movies.
TheAncientOne wrote:
Mertonan wrote:
Yes, Conan is a kids show watched by people of all ages. 6 year old kids to grandparents.
"For kids only" being the main point.
Interesting flexibility in definitions there.
You're directly comparing two different countries broadcasting. I hope you realize how idiotic and baseless that is. The seperation of demographics in America alone makes the comparison worthless (only MALES of a certain age get counted for something'? What about females?)
Please point out where I mentioned the word "males" anywhere in there. In the event you made the illogical assumption that I simply left that out, here is the latest listing from that site:
Not to mention ratings shares from two different airings that are two years apart mean nothing. If you really want to do that, you have to compare same week. Even comparing shares in the same week doesnt consider time slot or anything.
You're really delusional if you don't think animation on TV is a bigger deal in Japan than in America.
Here are more recent ratings for Japan:
Also note that the Anime in Japan ratings topic I linked to here at CR goes all the way back to 2008. If you think comparing the same week will make a significant difference, be my guest.
The delusion is that you think animation in Japan is so much more successful, when in fact in both countries, there are a handful of shows that garner significant ratings, while the remainder are clearly a niche market.
If you want a different perspective on how niche the bulk of anime is, go look up some of the highest figures for anime in Japan, and then compare them to something like this:
Even when you account for Japan's population being only 41% of the U.S., I think you'll have a difficult time coming up with an OVA in the past 5 years that sold over 66,195 copies (41% of the lowest selling title on that list), much less 280,510 (41% of the highest).
I mentioned OVAs, as that as what these "movies" are closest too, since they never aired in a theater, and were direct to video with any TV airing coming only some time after release.
No doubt you'll claim the U.S. titles sold more because they were priced left. Unfortunately for that claim, attempts in the past to boost anime sales in Japan with lower prices didn't turn out so well.
Back to your other claim that Japanese have no interest in American animation, perhaps we should discuss sales of Disney anime and Pixar movies in Japan.
Wow, you really how no idea how the video market works in Japan.
As someone who's lived in Japan a good chunk of his life, I think I would have better familiarity of how things go there than a random guy on the internet. You can't compare home video sales because they're handled completely different in Japan. Especially when a lot of DVDs are 'rent only' from video stores, and their only sales stem from what video stores themselves buy. The market is not structured the same as in the west, and there's not as much of an importance as buying home video as there is in the west. Usually only otaku buy DVD/BD of shows, and the only movies generate millions of units sold, like Miyazaki flicks. Using those numbers to judge anything means nothing.
And please don't use Disney movies as an example of anything. The movie market is again, entirely different from the television market. Movies here in Japan are treated different than in America.
Though if you want to look at revenue.
This shows the total earnings for Bandai products and merchandise for the first half of 2012.
I'l go ahead and translate some of them for you.
Mobile Suit Gundam: 20.5 Billion Yen
One Piece: 11.8 Billion Yen
Pretty Cure: 5.6 Billion Yen
Ben 10: 2.9 Billion Yen
Keep in mind Ben 10 sales are primarily American.. Japanese properties generate far more revenue and popularity than western franchises and animation does... the fact the biggest American cartoon pales in comparison to the weakest anime franchise says a lot.
Mertonan wrote:
You can't compare home video sales because they're handled completely different in Japan.
Apparently this conversation is pointless, as your time in Japan has made you the expert on how popular anime is in Japan, and facts and figures mean nothing since one "can't compare".
You even pulled out the "can't compare" claim on a top 10 list of Japanese programs, claiming first the list was too old (despite the fact that ratings for anime from the same period were available, as was a much newer list). You also claimed they would need to be for the same time slot, etc., despite that the purpose of ratings is to compare, and you had claimed "massive ratings" for anime.
Never mind that I have conversed with other people that have lived a "good chunk" of their life in Japan that differ with your opinion of how popular anime is there. Let's be honest. Except for the Bandai information, you have only offered claims and opinions, while throwing down the "can't compare" card on any facts and figures.
Japanese properties generate far more revenue and popularity than western franchises and animation does... the fact the biggest American cartoon pales in comparison to the weakest anime franchise says a lot.
So are we talking Japan only here or worldwide? If Japan only, I don't recall ever arguing that American animation was popular in Japan. That is only logical, since our animation is a bigger product here than anime.
If we are talking worldwide, and are apparently bringing merchandising into the mix, then consider this (otherwise you can skip this section, as it is not relevant):
Cartoon Network Enterprises at #21. (Other U.S. companies that have a heavy inventory of animation-related products appear higher, but I consider those results to "polluted" to be valid.
Sanrio appears at #7. This is one of the few Japanese companies that appear on the list that could be considered as heavily animation-related.
The Pokemon Company International at #34.
Back on the original subject, if Japanese care nothing for American animation, why is Curious George typically in the top 12 rated anime?
Shaun the Sheep was another one that appeared in the upper portion of the anime rankings when it was shown.
No doubt you'll once again pull out the "can't compare" card somehow.
Yes, that's my real age


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text:
At the 2000 GOP nominating convention in Philadelphia, candidate Bush created a fenced-in, out-of-sight protest zone that could only hold barely 1,500 people at a time. So citizens who wished to give voice to their many grievances with the Powers That Be had to:
(1) Schedule their exercise of First Amendment rights with the decidedly unsympathetic authorities.
(2) Report like cattle to the protest pen at their designated time, and only in the numbers authorized.
(3) Then, under the recorded surveillance of the authorities, feel free to let loose with all the speech they could utter within their allotted minutes (although no one–not Bush, not convention delegates, not the preening members of Congress, not the limousine-gliding corporate sponsors and certainly not the mass media–would be anywhere nearby to hear a single word of what they had to say).
Imagine how proud the Founders would be of this interpretation of their revolutionary work. The Democrats, always willing to learn useful tricks from the opposition, created their own "free-speech zone" when they gathered in Los Angeles that year for their convention.
Once ensconced in the White House, the Bushites institutionalized the art of dissing dissent, routinely dispatching the Secret Service to order local police to set up FSZs to quarantine protesters wherever Bush goes. The embedded media trooping dutifully behind him almost never cover this fascinating and truly newsworthy phenomenon, instead focusing almost entirely on spoon-fed soundbites from the President's press office.
An independent libertarian writer, however, James Bovard, chronicled George's splendid isolation from citizen protest in last December's issue of The American Conservative (www.amconmag.com). He wrote about Bill Neel, a retired steelworker who dared to raise his humble head at a 2002 Labor Day picnic in Pittsburgh, where Bush had gone to be photographed with worker-type people. Bill definitely did not fit the message of the day, for this 65-year-old was sporting a sign that said: The Bush Family Must Surely Love the Poor, They Made so Many of Us.
Ouch! Negative! Not acceptable! Must go!
Bill was standing in a crowd of pro-Bush people who were standing along the street where Bush's motorcade would pass. The Bush backers had all sorts of Hooray George-type signs. Those were totally okey-dokey with the Secret Service, but Neel's…well, it simply had to be removed.
He was told by the Pittsburgh cops to depart to the designated FSZ, a ballpark encased in a chain-link fence a third of a mile from Bush's (and the media's) path. Bill, that rambunctious rebel, refused to budge. So they arrested him for disorderly conduct, dispatched him to the luxury of a Pittsburgh jail and confiscated his offending sign.


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text:
By Sam Ade Oguns
Celtic defender Efe Ambrose is talking tough ahead of his club's battle against high-riding Juventus in the last 16 of the Champions League.
|Galatasaray v FC Schalke
Celtic v Juventus
Arsenal v Bayern Munich
Shakhtar v Borussia Dortmund
AC Milan v Barcelona
Real Madrid v Manchester United
Valencia v Paris Saint-Germain
FC Porto v Malaga
First legs will be played on either February 12/13 or19/20, with the return legs on March 5/6 or 12/13.
The draw on Thursday pitched the Italian giants against the Bhoys and when asked whether the pairing would halt the progress of Celtic in the competition, the Nigeria defender simply told Goal.com: "We fear no foe, the 180 minutes will decide our fate.
Ambrose insisted that it was high time people started treating Celtic with respect and that the team is not afraid of big names in the game.
He continued: "I can tell you honestly that it is a good draw for us and we are very happy about it. We have a united team and we believe in our quality and talent and most importantly, our coaches have been awesome and technically savvy.
"So like I said, we fear no foe but respect all our opponents as we want to make a statement in this competition.
The Hoops secured their passage into the last 16 with a 2-1 victory over Spartak Moscow on matchday six.
And Ambrose believes along with this win and the 2-1 victory over Barcelona at Celtic Park, they will take a lot of confidence into the match against the Serie A champions.
He added: "We have learnt a great lesson from our last match against Barcelona and I am confident that we will continue to improve as a team. We will surely be in the last eight with hard work and mother luck on our side."


text:
U.S. stocks rose, sending benchmark indexes to all-time highs, after the Federal Reserve said it will reduce the pace of its monthly bond purchases and expressed confidence in the labor market recovery.
Homebuilders rallied after the Fed said it may hold interest rates near zero even if unemployment falls below the 6.5% rate the central bank previously cited as a likely catalyst for an increase.
The Standard & Poor's 500 Index (CME:SPH14) added 1.7% to 1,811.07 at 4 p.m. in New York, surpassing its previous record close reached on Dec. 9. The Dow Jones Industrial Average climbed 296.50 points, or 1.9%, to an all-time high of 16,171.76. Both gauges posted their biggest gains in two months.
"It's confirmation that the Fed thinks the economy is strong enough to justify tapering," David Lafferty, chief investment strategist for Natixis Global Asset Management in Boston, said in a phone interview from Boston. His firm oversees $783 billion. "I'd contrast that with four or five months, when people were afraid of the taper. Now we had better economic data in the past four to six weeks, people were ready for it and markets have adjusted its expectations."
The central bank announced plans to cut its monthly bond purchases to $75 billion from $85 billion, taking its first step toward unwinding the unprecedented stimulus that Chairman Ben S. Bernanke put in place to help the economy recover from the worst recession since the 1930s.
'Modestly Reduce'
"In light of the cumulative progress toward maximum employment and the improvement in the outlook for labor market conditions, the committee decided to modestly reduce the pace of its asset purchases," the Federal Open Market Committee said today at the conclusion of a two-day meeting in Washington.
The central bank added that it "likely will be appropriate to maintain the current target range for the federal funds rate well past the time that the unemployment rate declines below 6.5%, especially if projected inflation continues to run below" the Fed's 2% goal.
The jobless rate fell to 7% in November, a five-year low, as employers added a greater-than-forecast 203,000 workers to payrolls. Unemployment was down from 10% in October 2009, during the recession, and up from 4.4% in May 2007.
Copyright 2014 Bloomberg. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


text:
Bone marrow is a soft, sponge-like material found inside certain bones, such as the heads of the femur (thigh bone) and humerus (arm bone), the sternum (breast bone), and the hip bones. Healthy bone marrow makes red blood cells, white blood cells, and platelets. The marrow may be damaged by cancer or cancer treatments. The inability to make healthy cells can make a range of health problems. For example, weak red blood cells make it difficult to transport oxygen throughout the body, low white blood cells weaken the immune system, and low platelets can lead to excess bleeding.
Bone marrow transplantation (BMT) replaces damaged bone marrow with healthy bone marrow from a donor. It may need to be done with cancers, such as leukemia, lymphoma, and myeloma, or related conditions such as myelodysplastic syndromes.
- How does bone marrow transplantation work?
- What is bone marrow transplantation used for?
- What are the types of bone marrow transplantation?
- What does bone marrow transplantation involve?
- What adverse effects can occur with bone marrow transplantation?
How Does Bone Marrow Transplantation Work?
Stem cells are predominately found in the bone marrow, but some occupy the bloodstream. These are called peripheral blood stem cells (PBSCs). If PBSCs are used in the transplant, it is referred to as peripheral blood stem cell transplantation (PBSCT). Umbilical cord blood also contains stem cells that can be used in stem cell transplantation.
When stem cells are transplanted, they enter the peripheral blood stream and travel to the bone marrow where they replace damaged stem cells and begin to make healthy blood cells. One advantage of using stem cells is that they can rapidly repopulate the full complement of blood and immune cells. Implanted stem cells find their own way to the bone marrow, as if they have a homing mechanism in place.
Stem cells can divide to form more stem cells or they can mature into blood cells.
What Is Bone Marrow Transplantation Used for?
BMT is used to sterilize the host bone marrow and replace it with healthy, noncancerous cells. Damage to stem cells can result from:
- Cancer process
- Chemotherapy
- Radiation therapy
Chemotherapy and radiation therapy destroy rapidly dividing cells like cancer cells and healthy stem cells. A potentially fatal side effect to these treatments results in the destruction of stem cells (a condition called myelosuppression). BMT cannot be used as a preventive measure or reverse damage if the bone marrow is completely destroyed.
Bone marrow damage can be caused by chemo- and/or radiation therapy that is:
- Directed at the bone marrow—Most common in treatment of blood cancers like leukemias or lymphomas.
- Not directed at the bone marrow—Other cancers are treated with systemic therapy that affects all cells in the body, including stem cells.
BMT and PBSCT are most frequently used in the treatment of the following cancers:
- Acute lymphoblastic leukemia (ALL)
- Acute myeloid leukemia (AML)
- Chronic myeloid leukemia (CML)
- Multiple myeloma
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Neuroblastoma
The roles of BMT and PBSCT are under investigation for the following cancers:
What Are the Types of Bone Marrow Transplantation?
In an autologous transplant, stem cells from your own peripheral blood or bone marrow are collected (harvested). They are placed in frozen storage (cryopreserved) prior to treatment of the cancer with high-dose chemotherapy. Once chemotherapy treatment is complete, the stem cells are reinfused (put back into your body). The stem cells will restore the bone marrow. The new blood marrow can restore production of red and white blood cells and platelets.
Prior to reinfusion, healthy stem cells are separated from any cancer cells that may be present in the harvested bone marrow. This is done to avoid reintroducing cancer cells into the bone marrow. However, it has never been shown that this filtering process is either required or effective.
In an allogeneic transplant, you receive someone else's stem cells. The donor's tissue type (which is different than blood type) must closely match yours. There are several types of allogeneic transplants:
- Syngeneic—The donor is your identical twin.
- Related—The donor is related to you, usually your sibling.
- Unrelated—The donor is no relation to you.
Only an identical twin has the same exact tissue type as your own. Any other sibling with the same biological mother and father has a 25% chance of matching your tissue type. If no one in your family is a match, your doctor can search for a donor in the National Marrow Donor Program's Registry.
The following tables list approximate 3-year disease-free survival rates for autologous and allogeneic transplants. Disease-free survival means that you are living without any evidence that your disease or cancer has come back.
*Complete remission (CR) is a decrease in tumor burden by several orders of magnitude. In addition, bone marrow examinations and peripheral blood counts are normal and there is no detectable leukemia elsewhere in the body. **Data for first 100 days after transplant only.
*Data for 1 year after transplant only. **Data for first 100 days after transplant only.
What Does Bone Marrow Transplantation Involve?
Whether the transplant is allogeneic or autologous, the procedure for harvesting the bone marrow is similar. The donor (which can be you or someone else) is given local anesthesia. Several small cuts are made in the skin over the area where the marrow will be removed (for example, the hip). A large needle is inserted through the cuts and into the center of the bone to withdraw the bone marrow. This process takes about 1-2 hours.
The harvested bone marrow is processed to remove blood and bone fragments. If the transplant is autologous, usable stem cells must be separated from any residual cancer cells. In the past, the harvested cells were mixed with chemotherapeutic agents or monoclonal antibodies. Since this purging process tended to remove some healthy stem cells along with the cancer cells, it is currently being replaced with other techniques that identify wanted cells, separate them out, and discard the cancer cells.
For an autologous transplant, the marrow may be immediately transfused back into you or cryopreserved (frozen) for many years. For an allogeneic transplant, the marrow is mixed with the preservative DMSO and cryopreserved until it is transplanted.
A process called apheresis or leukopheresis is used to obtain peripheral blood stem cells for transplant. For 4-5 days before the procedure, the donor (which can be you or someone else) may be given medication to increase the number of stem cells released into the blood stream.
During apheresis, a catheter is placed in a large vein in the neck or chest area or a needle is placed into a large vein in the arm. Blood is removed and sent through a machine that removes the stem cells. The blood is returned to the donor and the collected stem cells are stored. Apheresis takes about 4-5 hours. The collected cells, which may require treatment to remove unwanted cells, are frozen until they are transplanted.
Peripheral blood stem cell collection is now the preferred method of harvesting stem cells for transplant.
Details of the transplantation procedure vary with the cancer being treated. To prepare your body to receive the transplant, a conditioning regimen is generally required prior to any transplant. This involves the use of radiation therapy and/or high-dose chemotherapy in order to destroy the original cancer and create space in the marrow cavity for the transplanted stem cells to grow and replicate.
After the conditioning regimen, you will receive the stem cells through a central venous catheter, which is usually placed in the chest or neck. This part of the procedure is called the rescue process.
What Adverse Effects Can Occur With Bone Marrow Transplantation?
You may experience side effects associated with the transplant procedure. Most adverse events are caused by the conditioning regimen. The major complications associated with transplantation are:
- Graft failure or rejection
- Infection
- Pneumonitis
- Veno-occlusive disease
- Graft-versus-host disease
- Disease recurrence
- Short-term side effects
- Death
Graft failure or rejection is the failure of marrow recovery to return or the loss of marrow function after the initial period of recovery. It is a relatively rare occurrence, with an incidence of 5%-15%. If this occurs, your doctor may consider retransplantation.
Infection is the most common side effect of transplantation. About half of all infections occur in the first 4-6 weeks following transplantation. Usually, it is bacteria from your skin or gastrointestinal tract that leads to infection. Fever is the main symptom.
Fungal infections occur, but are far less common and account for about 10%-15% of systemic infection. Symptoms of a fungal infection include a dry, unproductive cough and change in breathing sounds. You may be given an antifungal agent to prevent infection.
Viral infections can occur too. Herpes simplex virus (HSV), which lies dormant in many people, may be reactivated. Other viruses associated with transplantation include cytomegalovirus and varicella-zoster virus. You may be given antiviral medication to help prevent or treat these infections.
To help prevent infection, your healthcare team will likely do the following:
- Maintain a protective environment
- Help you maintain good hygiene
- Frequently monitor your vital signs and perform complete examinations
Interstitial pneumonitis accounts for 40% of transplant deaths. This type of pneumonia usually occurs within the first 100 days of the transplant. Bacterial infections account for 20%-50% of cases. The most common viral cause is cytomegalovirus. Risk factors for developing interstitial pneumonitis include the following:
- Use of immunosuppressant drugs.
- Lung damage, which can result from the radiation used in the conditioning regimen.
- Total body irradiation.
- Presence of opportunistic infections—These are infections that take advantage of the fact that the body's normal defenses are compromised. Normally, your immune system would be able to fight these infections.
Symptoms include fever, a dry, unproductive cough, and shortness of breath. Pneumonitis is managed with medication.
Veno-occlusive disease (VOD) is a complication of the conditioning regimen for BMT. It occurs in about 20% of people undergoing allogeneic BMT and 10% of people undergoing autologous BMT. In VOD, there is occlusion (complete blockage) of the central veins of the liver, which results in venous congestion and damage to the liver cells. Symptoms include weight gain, enlarged liver, pain in the upper abdomen, high blood bilirubin levels, and ascites (fluid accumulation in the spaces between the tissues and organs in the abdomen).
Graft-versus-host disease (GVHD), an immune-mediated reaction, can occur after an allogeneic transplant. The white blood cells in the donor marrow identify your cells as foreign and attack them. This condition is usually treated with steroids or other immunosuppressive agents.
GVHD is divided into acute and chronic:
- Acute—This occurs within 100 days of transplant. Target organs are the skin, the gastrointestinal tract, and the liver.
- Chronic—This typically occurs more than 100 days after transplant. Almost every organ can be affected by chronic GVHD.
Cancer recurrence (relapse) is the most significant problem after BMT. Relapse is more common after an autologous transplant. This may be due to "hidden" malignant cells in the transplanted stem cells. Disease recurrence is the major factor related to long-term mortality, which means death more than 3 months after transplant.
Some short-term side effects that you may experience while undergoing this procedure include nausea, vomiting, fatigue, loss of appetite, mouth sores, hair loss, and skin reactions. Additional side effects may occur. Talk with your doctor for information and details specific to your treatment regimen.
Revision Information
- Reviewer: Mohei Abouzied, MD
- Review Date: 12/2016 -
- Update Date: 05/26/2015 -


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While traditional businesses are unlikely to look to dot coms for best practices these days, they might be surprised to find several in the area of marketing. Dot coms established a new standard for creating and managing relationships with customers, one which all companies--both online and off--will need to meet.
Organizations defining their core CRM principles should look at incorporating four Web principles: 1) permission
2) relevancy 3) value
4) dialogue
In the world of one-to-one marketing via the Web, permission marketing in its purest form means No Spam. It's about asking for permission before sending e-mail offers to customers and giving them easy ways to opt out. Most companies are doing an excellent job of getting permission from customers online, but it seems to stop there. However, permission is just as important and just as powerful across all aspects of the customer relationship.
In fact, efforts to obtain permission should be initiated during the courtship stage, before a prospect even becomes a customer. In the product push, acquisition-focused world, it's hard to imagine a telemarketer asking a prospect or new customer, "Is this a good time to talk?" But ideally, if we truly want to have a relationship with customers, that's exactly what we should do.
At the very first contact, we should ask our customers what channels they'd prefer for future interactions. We should get permission and then follow through to learn how and when they want to hear from us. Asking permission is scary for most marketers, because they believe most prospects and customers, when given the choice, would answer, "Don't contact me at all!" But without permission, it really is hard to have a relationship with customers. The challenge, then, is finding the best ways to secure permission. Relevancy and value can make the difference.
People seldom form relationships with others unless there is some common bond. They may continue a conversation with a stranger because they quickly discover they have common interests. Forming relationships with customers also requires that we find relevant shared interests.
Very simply, that means we need to spend time and effort early on understanding who our customers are, and what their likes and dislikes are. We can't guess those needs, preferences and attitudes--we have to ask. And we have to remember that people's likes and dislikes change. So, over time, we also need to track and remember those changes. We need systems and databases that will capture the nuances of the dialogue (demographics, interests, preferences and behavior) at each point of contact.
Most importantly, we need to use that information to ensure relevance in all aspects (service and sales) of the relationship, through each point of contact. Customers will stop revealing information about their likes and dislikes if we never act on the information to tailor our communications with them. So, don't ask for more than you think you will use.
Savvy e-marketers have learned that the key to getting permission is providing tangible value. Customers are willing to receive e-mail if they think they'll get something of value in return. That same principle applies to CRM. Customers will seldom prolong a relationship with a company that does not provide value. Value can take many forms beyond the immediate value of purchased products or services. Convenience, speed, ease of access, responsiveness, trust, integrity, education and service excellence are, in varying degrees, parts of the value equation for customers. This is where relevance and value have to merge. Understanding what constitutes value to the customer will be critical to maintaining and growing the value of the relationship to the organization.
A previous column discussed the Customer Experience Cycle (CRM Magazine, October 2000, Customer Care). Understanding this cycle for each customer can help you figure out what is valuable to him. If you know what stage of the purchase cycle he falls in and you have researched his role and his needs in that purchase cycle, then you'll have a very good idea what will create value for him at any given time.
We've asked permission, and we think we know what might be relevant. And we think we even know what will be valuable to the customer. The next step is to create dialogue. This may be the hardest of all for marketers and service personnel. Traditional marketers are great at one-way communication. They know how to generate leads and how to market products. Service and call center staff are used to having conversations with customers in certain controlled situations. They know how to respond to customer inquiries and answer the specific questions they are most often asked or how to solve a customer problem. But marketers and service personnel have not been traditionally trained how to actually create a dialogue with customers.
Web marketers know that they need to focus on providing content or information as part of the value proposition. Dialogue for them means giving a little to get a little. "If I provide you with some needed information, you'll tell me a little bit about yourself." And the exchange of information--the dialogue--goes on until the customer has told the Web marketer all about her attitudes and preferences and has given permission to "keep her updated" on products and services of interest. Marketing or sales no longer look like self-serving promotion. Instead, the dialogue has transformed the sales message into what is perceived as exceptional customer service.
Measuring Results
Marketing performance typically has been based on advertising reach or how many pieces mailed or perhaps on direct mail program response. Service and support personnel typically have been measured on how quickly they successfully complete a call and resolve a customer problem. But you cannot measure the immediate impact of creating a dialogue. While these traditional metrics are important, measuring performance in a CRM environment requires looking at the long-term impacts on customer lifetime value.
Though Web marketers may not know everything they should about how to track and measure promotions or how to acquire customers profitably, they have set the standard for delivering value and relevance and for creating a dialogue with customers. Click and mortar marketing, sales and service managers must now rise to the challenge of profitably adopting and operationalizing permission, relevance, value and dialogue across all points of contact.


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Influenza ("the flu") is:
Individuals with the flu are infectious 1 - 2 days before showing symptoms and during their entire illness.
Symptoms of the Flu:
Seasonal Flu
The seasonal flu presents each year, giving most people some immunity from previous exposure. Health systems can usually meet public needs.
Read More >>
Pandemic Flu
A rarely occurring phenomenon, pandemic flu arrives with little, if any previous exposure to human populations. Health systems may be overwhelmed.
Read More >>
An effective prevention measure against influenza is vaccination.
The Flu Shot Locator provides a searchable map showing where clinics can be found anywhere in Indiana.
Contacting your Local Health Department will also provide locations in your community where vaccination clinics can be found.


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The motor experiences that draw visitors to Daytona Beach range from car races to Bike Week, an annu...


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This week on the io9 show, we share our summer science fiction must-read list — so you can escape to other worlds when you hit the beach. We also interview Kim Stanley Robinson about his brand new book, 2312.
You can catch more episodes of the io9 Show on YouTube or Revision3. We're also on iTunes! Tune in every Friday for more startling revelations from the world to come!


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White Papers and
Application Notes
- Thermal Management of Buildings
- Hardware and Simulation Software Advancements
- Modeling the Lithium-Ion Battery
Conference Collections
- User Presentation 2017
- User Presentation 2016
- User Presentation 2015
- User Presentation 2014
- User Presentation 2013
Additional Reading
Positioning System for Particles in Microfluidic StructuresD. Kappe[1], A. Hütten[1]
[1]University of Bielefeld, Bielefeld, Germany
The possibility to detect and probe molecules in microfluidic devices gives rise to interesting applications. There are different approaches how to detect and probe particles, but a common step, for most methods, is to place the particles on a sensor. This can be done by applying external field gradients, or in this case by utilizing gravitational and hydrodynamic effects. Therefore, the sensor is placed beneath a microfluidic structure of changing height. Numerical simulations for various flow rates show, that the amount of captured material can be significantly increased in comparison to a straight channel. The geometry can be adapted to different flow rates, at the cost of higher aspect ratios and a longer ramp.
- kappe_presentation.pdf - 0.42MB
- kappe_poster.pdf - 1.6MB
- kappe_paper.pdf - 0.34MB
- kappe_abstract.pdf - 0.1MB


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Seatbelts? We don't need no stinkin' seatbelts!
Imagine if you will a yellow cab on the streets of Anytown, USA. This cab is .
. . special. Unknown forces have made this convertible cab, and its occupants,
completely indestructible. This cab careens down the main streets, looking for
fares and causing millions of dollars of property damage. Where would you go in
an indestructible cab? Why, Kentucky Fried Chicken, of course!
Crazy Taxi is one of the most anticipated releases for the Dreamcast.
This arcade hit has been ported to the Dreamcast perfectly, which is both a
good thing and a bad thing. Everything that the arcade had is in this game.
Unfortunately, everything that the arcade lacked is in here as well.
The idea is simple. You drive a cab around a huge city, pick up paseengers,
and take them to their destination in one piece. Plowing through traffic with
reckless abandon, Crazy Taxi is the definition of an arcade racer. This
is no sim.
First off, this game is hard. Even when you do really well, don't expect to
be ranked above 10 on the high scores list. But while the game is difficult,
it's not frustrating. In fact, making the game hard was a good thing for the
designers to do, as it really extends the life of the game.
Every time I think the Dreamcast can't surprise me, it happens again. Crazy
Taxi is no exception. The detail of the city is fantastic, from the signs
on the buildings to the movement of the pedestrians. Where Crazy Taxi
really shines is in the framerate. This game is faster than a rabbit at a greyhound
convention. Because of the amazing framerate and the smoothness of motion, gamers
can ignore the minor popup on the horizon and the disturbing lack of skid marks.
Apparently your tires are indestructible, too.
The control is a little wily at first, but you get used to it after a while.
Also, the special "Crazy" moves are tough to learn since they involve motions
that you don't normally associate with a driving game. Once you get them down,
however, the game becomes much easier. There is only one word in the English
language that can properly define the gameplay: fun. Crazy Taxi
is simply a blast to play. Picking up fares, racing across town, ramming into
buses . . . it's all good. My only complaint is that there just isn't enough
Taxi was designed as an arcade game, the type that encourages you to pump
in quarter after quarter to continue. The most time you might spend on a game
is an hour, maybe two if you had enough quarters. Once the game makes it to
the home consoles, however, that type of design just doesn't work anymore.
Home console ports of arcade games need to have depth, and that's what Crazy
Taxi lacks. Though they added an extra city for the home version, it's just
a different layout using the exact same structures and textures. That makes
a whopping two cities you can drive in. They also added the Crazy Box,
essentially a really tough training mode. Are there special options if you win?
No. Are there extra characters you can unlock? One, and only if you beat the
Crazy Box. Don't get me wrong, the game is lots of fun, but it could have been
so much more.
Same goes for the music. Using bands like Offspring and Bad Religion is great
if you only play the game for an hour. But countless hours of hearing the same
seven songs over and over will drive anyone nuts. Because they're popular bands
and not just run-of-the-mill background music, it's hard to ignore the repetitive
nature of the soundtrack.
Though it really didn't have an effect on the grade, I do feel the need to
mention the advertising in Crazy Taxi. This game has, bar none, the best
advertising I've ever seen in a game. Instead of making the sponsors overt,
they slid them into the gameplay. One passenger might want to go to KFC, so
you drive to a KFC building, complete with recognizable architecture and a sign
to boot. Another might want to go to Tower Records or the Fila store. One might
ask why a person would pay a cabbie $500 to go to KFC…personally, I'd pay
that much to go in the opposite direction.
Crazy Taxi is a case where a great arcade game became a good home game.
Though the game is a ton of fun, the serious lack of depth keeps it back from
true greatness. Hey Sega, next time look into car upgrades, more cities, and
some sort of two player. Then you'd have a classic on your hands.


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Deutsche Bank Cleanup Yields Loss
Restructuring, Litigation Costs Weigh on German Lender, but Shares Gain as Capital Buffer Grows
FRANKFURT—Deutsche Bank AG reported a steep fourth-quarter loss as it was hit by ongoing restructuring and litigation costs, but its shares climbed on news that it increased its capital cushion faster than investors had expected.
The bank posted a fourth-quarter net loss of €2.17 billion ($2.94 billion), compared with a profit of €147 million in the same quarter last year. Net income for the full year was €611 million, down sharply from the €4.13 billion earned in 2011....


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The Dyersburg Mall has fetched $4.35 million after hitting the online auction block in November.
Yazoo, Miss.-based Action Properties LLC purchased the 191,038-square-foot regional shopping mall at 2700 Lake Road in Dyersburg, Tenn., under the entity Action Dyersburg LLC. The seller, Jackson, Miss.-based Mattiace Properties Inc., disposed of the asset under the entity Dyersburg Mall Co. LLC.
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I have a question about the website AllVerbs.com.
Sometimes when you look up a Latin verb, some of the listed conjugations come out in red text and some of them come out in blue text.
For example, if you look up the verb "eripio" you will see that the past perfect comes out in red font. Also some of the imperfect subjunctive, or as they call it "conjunctive", is displayed in blue font.
I am not sure what this means, I would contact them to ask, but there is no 'contact us' page. So I have no way of asking anyone that is behind the site.
My first guess would be that the red font indicates a tense that simply does not exist.... Perhaps "eripio" is a semi-deponent verb, so the past tense is expressed as "eruptus est" instead of "eripuit"???
As for the blue text, maybe that indicates a verb tense that would exist but there is no way that action could have meaning if expressed in that tense???????
Or maybe the red font just means that they (the site developers) have not confirmed that the listed conjugation is definately correct??