Under the new technical condition, the promotion of equipment complexity and high-tech features makes a significant increase in the workload of equipment support. Commands of support organizations become more complex. In order to meet these demands, the equipment support system has gradually evolved to the network structure. Network-centric equipment support system will become the development trend of support system. Based on the materials transportation functions of support system, this paper abstracts it into a network structure. According to support task nodes are divided into two types, support nodes and demand nodes, which stand for support stations and materials demand entities. Transmission lines between the nodes, which transport support materials from support nodes to demand nodes, are abstracted as links of the network. According to the topology structure of the backbone support network this paper analyzes it based on network structure. Firstly, a network model including support nodes and demand nodes is established; Secondly, support tasks are described based on the support network model; a task demand model is built, as well as functionality and performance models of the model nodes. In this model, a support node gives service to certain demand nodes. When the support node reach its maximum capacity, its demand nodes can seek service to another support node nearby. Lastly, according to the task model of support network and Monte Carlo simulation, a mission reliability evaluation method is built, which supposes demand nodes submit to a certain failure distribution, missions are driven by failures, regards processing capacity of support nodes as constraint conditions, and that support nodes can meet the mission requirements is the criterion. Based on an aircraft support system, this paper abstracts it into a network model. The mission reliability of the support network under the random nodes failures conditions is analyzed and evaluated. In this paper, a new mission reliability modeling based on network structure is designed in support system. Compared with former support network model, it considered about demand node's failure rate and the network's mission reliability. The mission reliability of support network is primarily analyzed and evaluated.


An exact analytical solution is obtained for the attitude motion of a class of asymmetric dual-spin spacecraft which may be modeled as free systems of two rigid bodies, one asymmetric and one axisymmetric. The type system considered constitutes a gyrostat. The symmetry axis of the axisymmetric rigid body and either the axis of the largest, or that of the smallest, moment of inertia of the system are assumed to be parallel. Zero internal torque is assumed also. The integral of rotational angular momentum of the system, an integral of energy of the system and the constancy of the symmetry-axis component of rotational angular momentum of the symmetric body are used to reduce the solution of the problem to quadratures, which are evaluated in terms of Jacobian elliptic functions and elliptic integrals. Internal resonances, which may exist in imperfect spacecraft, are discussed. Resonance curves, constructed using the exact solution, are presented for a typical, asymmetric, dualspin spacecraft.


Humans are intimately connected to nature, and our physical and mental health is influenced strongly by our environment. The "elements," classically described in humoral theory as Fire, Water, Earth, and Air, all may impact our mental health. In a contemporary sense, these elements reflect a range of modifiable factors: UV light or heat therapy (Fire); sauna, hydrotherapy, and balneotherapy (Water); nature-based exposure therapy and horticulture (Earth); oxygen-rich/clean air exposure; and breathing techniques (Air). This theoretical scoping review paper details the emerging evidence for a range of these elements, covering epidemiological and interventional data, and provides information on how we can engage in "biophilic" activities to harness their potential benefits. Interventional examples with emerging evidentiary support include "forest-bathing," heat therapy, sauna, light therapy, "greenspace" and "bluespace" exercise, horticulture, clay art therapy activities, and pranayamic yoga breathing exercises. Further robust research is however required to firmly validate many of these interventions, and to establish their therapeutic applications for the benefit of specific mental health disorders.


In this paper, a multi-objective tuning algorithm is proposed for the voltage/current controllers of the dynamic voltage restorer (DVR) in an optimal manner in order to improve the fault-ride-through (FRT) capability of the grid-connected doubly-fed induction generators. An active crowbar protection (ACB_P) coupled with the rotor of the DFIG, provides a very little compensation, on blocking the high rotor current during fault condition. Control of DVR is achieved through use of multiple PI controllers. This paper presents a novel multi-objective tuning known as Autonomous Group Particle Swarm Optimisation (AGPSO) to optimally tune the PI controllers. The optimisation algorithm uses diverse autonomous groups confined within a common target to achieve more directed and randomised search results for any population. Voltage sag compensation, total harmonic distortion (THD), RMS value of signal are the three major indices for comparison study during fault. Finally, the performance improvement in FRT of the DFIG with optimised controller was studied through DFIG responses on comparing with normal controller. Efficacy of the proposed controller proposed is verified by a simulation model of DFIG System with 1.5 MW rating in MATLAB. The results are analysed and comparative data are placed to ensure the enhanced FRT capability of the system.


ABSTRACT This article studies how possible it is to use the need to protect vulnerable populations, such as children, as a justification to limit freedom of expression in democratic societies. The research was designed and conducted based on the idea that the regulation of speech and access to content is not only a matter of law and legislative interpretations, but also a question of social norms and values. The study is based on two surveys, one implemented with a representative sample of Norwegians aged 15 and older, the other with a sample of journalists. The results show that for the general population sample, 76% of respondents agreed that the protection of weak groups, such as children, is more important than freedom of expression. The data analysis also shows that gender, education, religious affiliation, trust in media and fear of a terrorist attack are all linked to the likelihood of agreeing with this statement. Women are 66% more likely than men to be in favour of limiting freedom of expression to protect weak groups, such as children. While the numbers of those who agree are lower among journalists, up to 50% of journalists still totally or partially agree that protecting weak groups is more important than freedom of expression. We discuss the policy implications of these results for democratic societies.


It is a commonplace of contemporary moral theory to divide normative ethics into deontological and teleological. Both of these theories attempt to answer the question: What ought I to do? Therefore their object is actions rather than agents. The most common teleological theory in morals is utilitarian; utilitarian moral theory emphasizes the concept of good, and what is right is determined, according to classical utilitarians, as that which is productive of the greatest good for the greatest number. The deontologist, on the contrary, believes that right (or duty), rather than good, is the fundamental moral concept. That which is right ought to be done simply because it is the right thing to do or is our duty. In either case, virtue is handmaiden to another (central) moral concept; that is, in the former case, it is a disposition to produce the greatest possible good and, in the latter, a disposition to do what is morally right or our moral duty. What in recent years has been called virtue ethics, however, has a different thrust. Virtue ethics theorists, in the main, take their inspiration from ancient Greek philosophers, especially Aristotle. This movement is often traced back to works by Elizabeth Anscombe and Philippa Foot.1 They attempt to make virtue and vice, and therefore the agent, basic to moral theory rather than the intrinsic Tightness of, or morally good consequences of, actions. However Alasdair Maclntyre (After Virtue) is the most influential virtue ethics theorist.2 Maclntyre, Anscombe, and Foot take a neo-Aristotelian approach to virtue ethics. Given the consensus, at least among philosophers who do business ethics, that some knowledge of ethical theory is necessary in order to deal intelligently with moral problems in corporate business, it is


This research has examined the combustion and emissions of a spray-guided direct-injection spark-ignition (DISI) engine using exhaust gas recirculation (EGR). The impact of EGR type, swirl and tumble intake airflows, compression ratio and fuel type were also investigated.

EGR addition resulted in significant fuel consumption improvements and differing particulate matter (PM) behaviour depending on the knock limited maximum brake torque (KLMBT) spark advance achieved. When comparing EGR types, cooled EGR achieved the best fuel consumption and cooled EGR after three-way catalyst (TWC) achieved the best gaseous emissions (NOx and HC).

Swirl and tumble intake airflows significantly increased fuel consumption. However, these increases could be minimized with EGR addition. Swirl significantly reduced the accumulation mode particulate emissions, providing a potential solution for PM reduction. EGR addition did not significantly affect PM for the swirl and tumble intake airflow conditions.

20%vol 1-butanol addition to gasoline fuel (Bu20) resulted in significant PM reductions at 8.5 bar IMEP. At 7.0 bar IMEP, EGR addition allowed the KLMBT spark timing to be advanced, as the compression ratio was increased. Fuel consumption was improved by 0.4% due to the spark advance and reduced pumping losses, and PM improved because the formation of primary particles was reduced.


Taking Chongzuo City of Guangxi Province as an example,the employment effect of the resources-based industrial cluster in southwest of Guangxi Province is analyzed according to the data from the Statistical Yearbook of Guangxi and Chongzuo from 2003 to 2008 and from the relevant sections,and the four employment effect of industrial cluster——the spatial expansion effect of employment chain,optimizing effect of employment structure,the multiplicative effect of employment absorption and the effect of improving the quality of labors and the effect of the intensity of employment and location quotient of employment.Results show that the employment absorption of sugar industry in Chongzuo City is stable and upward slightly,and shows strong employment effect;the sugar industry in Chongzuo is not only competitive,but also has a great share of market in employment,so it shows strong absorption of employment.The countermeasures for improving the employment level of resource-based industrial cluster in southwest of Guangxi Province are put forward,including elongate industrial chain and widen employment space;strengthen various kinds of formal and informal training to improve the employment capability of laborers;lay stress on industrial structure and optimize the employment structure;strengthen the construction of the industrial economic zone towards ASEAN(Association of Southeast Asian Nations),and fully display the regional advantages of the coastal location.


ONCE extracted from tissue, the stability of ribosomal particles has been found to be dependent on the ionic strength of the medium, and on the concentration of divalent ions such as magnesium (TISSI~RES and WATSON, 1958; Ts'o, BONNER and VINOGRAD, 1958; HAMILTON and PETERMANN, 1959), polyamines (COHEN and LITCHTENSTEIN, 1960) and urea (ELSON, 1958; TASHIRO, SHIMIDZU, HONDE and INOUYE, 1960). KIHARA, HALVORSON and BOCK (1961) observed the effect of various agents such as phosphate, sodium chloride, ammonium chloride, borate, urea, etc, on the stability of 80s particles of yeasts and showed that the degradation of the ribosomes was accompanied by the release of ribonucleic acid, nucleotides, proteins and ,+glucosidase. HULTIN (1961) reported the energydependent release of labile proteins from pre-labelled rat liver ribosomes. The chromatolytic cycle which the RNA-rich basophilic Nissl granules of brain tissue undergo during stimulation or stress has focussed attention on the stability of these ribonucleoprotein particles, present in the Nissl granules, which play an important role in metabolism in normal as well as during different functional activities of brain. In the course of investigations on the integrity of brain cortex ribosomes, a study has been made of the stability of the isolated ribosomes in the presence of various agents. The decreased stability ribosomes has been measured by the release into the medium of proteins, RNA, acid-soluble nucleotides, ribonuclease (E.C. 184.108.40.206) and alkaline phosphomonoesterase (orthophosphoric monoester phosphohydrolase). The results are presented in the present note. The brain tissue obtained from freshly slaughtered goats was kept cold in ice, the cortex freed from white matter and homogenized at 0" (all subsequent operations were made at 0-4", unless stated otherwise) in 0.005 M-magnesium-cacodylate buffer, pH 7.0, containing 0.25 M-sucrose (referred to later as MC-sucrose buffer). The cell debris and mitochondria1 residues were removed by centrifugation at 10,000 g for 20 min. To the microsome-containing supernatant was added slowly a 5 % sodium deoxycholate solution (in MC-sucrose buffer) with constant stirring for 15 min, the final concentration of sodium deoxycholate being 0.5 %, at which point the supernatant became clear. This was centrifuged at 88,000 g for two hr in a Spinco Ultracentrifuge model L. The pellets obtained were suspended by homogenization in a 0.5 % sodium deoxycholate solution (in MC-sucrose buffer) and recentrifuged at 88,000 g for one hr. The pellets were then washed by suspension in the MCsucrose buffer by centrifugation as above. Finally the pellets, which were light brown in colour, were suspended in the MC-sucrose buffer and homogenized to obtain a uniform suspension of the ribosomes. The purity of the ribosome fraction was judged by the constant ratio of protein to RNA and by the absence of marker enzymes and constituents such as aldolase, glucose 6-phosphatase, succinate dehydrogenase and deoxyribonucleic acid. In order to test the stability, the ribosomes were suspended in media containing various agents and the release of Components was measured (Table 1). Results show that the brain cortex ribosomes are most stable in magnesium-cacodylate buffer, pH 7.0, as indicated by the minimum release of protein and nucleic acid components in the buffer. The release is very marked in presence of sodium chloride, ammonium chloride and divalent ions like magnesium and manganese. This may be an effect of the high salt concentration of the media. The higher release of protein in presence of ethylenediaminetetra-acetate (EDTA) than in control is probably due to the removal of the constituent magnesium ions which are known to stabilise ribonucleoproteins (CHAO and SCHACHMAN, 1956; PETERMANN and HAMILTON, 1957; TISSI~RES and WATSON, 1958; Ts'o, BONNER and VINOGRAD; 1958). The amount of protein released in presence of phosphate is also high. KIHARA, HALVORSON and BOCK (1961) found a remarkably high release of protein (about 50 per cent) in 0.5 M-phosphate in their study of the stability of yeast ribosomes. The effect of urea (4.0 M) on the brain cortex ribosomes is very marked, causing the release of the highest amounts of both protein and nucleic acid components. This may be owing to the rupture of the hydrogen bonds existing between the RNA and protein moieties leading to their release into the medium. The released proleins have been found to possess both acid ribonuclease and alkaline


Vehicular Ad hoc Network in a highway is composed of high speed vehicles or nodes which induce fast topology changes in their configuration. In order to solve the connectivity and scalability problems of VANETs, we introduce the architecture of a Vehicular hybrid ad hoc network (VHANET). Using some routing protocol extensions, the VHANET allows ad hoc islands to be interconnected among each other using a infrastructure network. Our simulation results show that the performances, compared to a flat network, are greatly enhanced. In addition, we study a nearly optimal AP density for the use of our architecture.


ABSTRACT Land-use conversion affects the soil community and microbial abundance, which are essential dynamic indicators of soil quality and sustainability. However, little to no work has been performed to analyse the impact from different land-use histories (i.e. fallow, tea, rice, banana, and maize) on the microbial abundance and diversity in the soil of sacha inchi (Plukenetia volubilis L.). Real-time quantitative PCR (qPCR) was performed to quantify soil bacterial and fungal abundance. Denaturing gradient gel electrophoresis (DGGE) combined with cloning and sequencing was used to assess the microbial communities. Our results showed that the bacterial and fungal abundance in fallow land-use conversion soils was significantly lower than that in the other four land-use conversion soils (tea, rice, banana, and maize). Moreover, the highest abundance of bacteria and fungi was detected in the soils converted from maize to sacha inchicultivation. In addition, canonical correspondence analysis (CCA) showed that the total N and pH were significantly related to bacterial and fungal community structures. These results suggest that land-use conversion from maize fields to sacha inchi farms is an effective way to maintain the soil microbial quantity and hence the sustainability of the soil.


Background and purpose:Non-small cell lung cancer (NSCLC) is the most frequent histological type of the lung cancer. There are significant differences of prognoses among the patients with advanced NSCLC patients after chemotherapy. The purpose of this study was to explore the prognostic factors of advanced NSCLC patients after chemotherapy. Methods:204 advanced NSCLC patients after chemotherapy were enrolled in the Oncology Center of Shandong Provincial Hospital from Feb.1998 to Jul.2006. Kaplan-Meier method and Log-rank time series analysis for the univariate analysis and Cox proportional hazard model for the multivariate analysis were used. Results:The median survival time was 12 .2 months, 1 year survival rate was 54.9%. The univariate analysis suggested that TNM staging (P=0.0075), KPS scoring (P=0.0151), chemotherapy regiman (P=0.0325), the chemotherapy cycles (P=0.0298) and the status of patients' immediate response to the treatment (P=0.0061) significantly influenced survival of NSCLC. Multivariate analysis suggested that KPS scoring (P=0.019), TNM staging (P=0.011), and the status of patients' immediate response to the treatment (P=0.009) were the independent factors of survival. Conclusion:KPS scoring, TNM staging and the status of patients' immediate response to the treatment are the independent prognostic factors for advanced NSCLC patients after chemotherapy.


We assess moral hazard in Australian ancillary or extras (nonhospital) private health insurance (PHI) relating to dental care services using the longitudinal data in the Household, Income and Labour Dynamics in Australia (HILDA) Survey. Cross-sectional probit regressions specify dental care (the most important expenditure component of ancillary cover) as a function of endogenous PHI policy holding, self-assessed health condition, health risk factors and socioeconomic controls including age, income, education, family structure and welfare status. We find that moral hazard is present resulting in the possible overuse of dental care services by PHI holders, bearing in mind this is overuse in relative rather than absolute terms. However, we also find using dynamic analysis that while there is no evidence of pent-up demand (previously uninsured policyholders accessing more dental care services initially) any sort of PHI holding, however sporadic, is always associated with significantly more likely use of dental care services than persons that have never held PHI. This supports the role of PHI in fostering good health care behavior and possibly countering ex ante moral hazard.


After the peace treaty between England and Spain was signed in 1604, the 'Spanish faction' at the English court had reasons to feel emboldened. King James I, immediately following the peace, attempted to make the agreement binding by negotiating a dynastic marriage with the Spanish Habsburgs initially for his son Henry, then, after Henry's untimely death, for his son Charles. This contribution aims to assess the extent to which the position of the 'Spanish faction' shifted during James I's reign. The very lack of a dynastic union between England and Spain merely exacerbated the growing tensions between the English King and his political nation, leading to the decline of the 'Spanish faction' at the English court and to the outbreak of war between England and Spain in 1625.


Users' continuance usage is critical to mobile service providers' success. Drawing on the Unified Theory of Acceptance and Use of Technology (UTAUT) and flow theory, this research identified the fa...


This paper introduces an aggregate demand externality into a model of irreversible investment. The central result of the paper establishes the mechanism in which increases in uncertainty can lead to suboptimal recessions. These inefficient outcomes occur even if agents are allowed to coordinate to the best possible equilibria. The result is driven by the external effects of firms' investment decisions. Copyright 1997 by The London School of Economics and Political Science


Wierman, Matthew Kenneth Ph.D., Purdue University, December 2014. Measurement of Combustion Response to Transverse Modes at High Pressure. Major Professor: William E. Anderson. A two dimensional transverse combustor capable of producing and modulating an unstable flowfield was tested at Purdue. The combustor used an array of coaxial ox-centered shear injector elements. The oxidizer posts were able to be discretely changed in length between tests to investigate different post resonance conditions. A single Study element was placed in the middle of the driven unsteady flowfield so its response could be measured using pressure measurement and high speed imagery. This approach was supported by past testing of the longitudinal Continuously Variable Resonance Combustor and past transverse chambers. Mean flow rates and pressures were fixed across the series of tests. Phase lag data between pressure measurement locations support a simple linear post-to-chamber interaction mechanism. Phase lags between chamber measurements were unaffected by the change in oxidizer post length. Scaling was established between amplitude levels and post lengths between the longitudinal and transverse combustors, which further supported the proposed post-to-chamber response mechanism. High speed imaging of OH* chemiluminesence was used as a marker of heat release. Mean flame behavior showed broad distribution and flame shortening at high forcing amplitude and compact, elongated flame shape at low forcing amplitude. Multiple image analysis techniques were utilized to process these data. Proper orthogonal decomposition and dynamic mode decomposition showed spatial and temporal character of image time slices sorted by descriptive content and frequency, respectively. These analyses both identified significant behavior at the same frequencies as chamber pressure perturbations.


In this work, we study the arising of correlations among some isoscalar ($K_o$, $Q_o$, and $I_o$) and isovector ($J$, $L_o$, $K_{sym}^o$, $Q_{sym}^o$, and $I_{sym}^o$) bulk parameters in nonrelativistic and relativistic hadronic mean-field models. For the former, we investigate correlations in Skyrme and Gogny parametrizations, as well as in the nonrelativistic (NR) limit of relativistic point-coupling models. We provide analytical correlations among bulk parameters for the NR limit, discussing the conditions in which they are linear ones. Based on a recent study [B. M. Santos et al., Phys. Rev. C 90, 035203 (2014)], we also show that some correlations presented in the NR limit are reproduced for relativistic models presenting cubic and quartic self-interactions in the scalar field $\sigma$, mostly studied in this work in the context of the relativistic framework. We also discuss how the crossing points, observed in the density dependence of some bulk parameters, can be seen as a signature of linear correlations between the specific bulk quantity presenting the crossing, and its immediately next order parameter.


The commonly accepted linear stability analysis for the forward-time centred-space (FTCS) algorithm applied to the transport equation has led to the concept of a cell Reynolds number restriction on the spatial grid size. This paper shows where the commonly accepted original analysis is in error and presents the correct stability restrictions, which are restrictions on the time step, not the spatial grid size. There is no cell Reynolds number restriction. The results are confirmed by numerical computations for the two-dimensional driven cavity problem.


The writer discusses Justus Lipsius's affection for his dogs in the context of the humanist tradition and iconography, and Ruben's painting The Four Philosophers. Lipsius's attitude towards his dogs should be examined in the light of many learned humanists at the time being engaged in poetic jeau d'esprit, pitting their own talent against that of Catullus in descriptions of various animals. A similar spirit of imitato lies behind the tradition of composing animal epitaphs, as Lipsius did for his dog Saphyrus. This humanist background is even clearer in Lipsius's letter on dogs, which not only displayed the breadth of his erudition, but was also meant as a stylistic exercise to be imitated by his students. In respect of iconography, the dog that appears in The Four Philosophers is likely to be Lipsius's dog Mopsus; it was probably meant to be the embodiment of the virtues of a good dog, and therefore, a good scholar.


Well, yes, a somewhat artificial debate; none of us would seriously argue that neither genes nor the environment are unimportant in multiple sclerosis (MS) pathogenesis. These two intellectually elegant and robustly argued opinion pieces typify the academic jousting indicative of a healthy scientific dialectic. Both debaters concede that the nature– nurture interaction is important, the relative weighting of the effects is different. Sawcer's argument using phenylketonuria is well taken and illustrates the difficulties with association studies and the relative frequencies of unnecessary insufficient causal factors. The most compelling epidemiological evidence of an environmental effect relates to the seven-fold increase in prevalence and incidence of MS and clinically isolated syndrome (CIS) going from North Queensland to Hobart in Australia.1, 2 However such an environmental effect seems less relevant living on an island where everyone is vitamin D insufficient in winter/spring and yet there is a two-fold difference in MS prevalence over a distance of only 500 km.3 The debate between nature and nurture is also seen in Parkinson's disease (PD) where up to the year 1997 environmental factors were considered predominant. Since that date with the description of the Contorsi kindred and the Ala53Thr mutation in the gene coding for alpha-synuclein, genetic factors for PD has held sway.4 Understanding the monogenetic disorders causing PD has increased our knowledge of its pathogenesis; research into environmental factors of relevance to most patients with PD has not been productive. In contrast with MS research we are in a much happier state with a dynamic intercourse (and discourse) between genes and environment. Environmental influences are attractive to the neurologist in practice since they indicate possible interventions by which one might ameliorate the disease course. Perhaps, if vitamin D supplementation is convincingly shown to affect disease activity in MS in randomized controlled trials, then it might be possible to demonstrate a differential effect in patients who have or do not have the HLA DRB1*15:01 genotype. However, in some of the reported environmental associations, as indicated by Sawcer, there is the problem of reverse causality which in part may relate to cigarette smoking and MS disease severity. These two opinion pieces illustrate the value of this debate series. This is not just an opportunity for polemic, to establish the superiority of one view over another. Debate on apparently dichotomous issues may stimulate us all to think more about this disease.


Nanoreactor frameworks have many advantages over bulk catalyst structures in terms of providing a regular reaction environment and conformational stability. In this work, Au@SiO2 nanoreactor frameworks were chemically modified to improve the catalytic efficiency of o-nitroaniline reduction. The porosity of silica shells was readily controlled by introducing C18TMS as a porogen with heat treatment. The diffusion rate of the silica layers was tuned from 5.9 × 10−19 to 2.1 × 10−18 m2 s−1, which directly altered the turnover frequency and rate constant of the reaction. Carboxylate functionality was introduced on the gold cores of Au@SiO2 nanoreactors by 3-MPA addition. The reaction rate was enhanced by a maximum of 2.4 times compared to unfunctionalized catalysts through a strong interaction between carboxylate anions and o-nitroaniline. Totally, the rate constant of Au@SiO2 yolk−shell nanoreactors exhibits a 13-fold enhancement by diffusion and surface functionality control. These results indicate that the r...


Ceroid-pigment is present in the smooth muscle fibers of the gastrointestinal tract of patients with cystic fibrosis of the pancreas. It is first seen during the second year of life. It is found in all patients of 5 years of age and older, and the amount increases with age. It has not been found in other pediatric conditions with the exception of biliary atresia and cirrhosis of the liver. Extensive ceroid deposit probably represents an expression of prolonged and severe vitamin-E deficiency, related to protracted malabsorption of fat-soluble tocopherols. Alterations of striated muscle appear to be rare and minimal in cystic fibrosis of the pancreas.


The integration of psychology into multidisciplinary care for people affected by 'disorders of sex development' is acknowledged in most recent care standard documents. However, psychological evidence that can inform service development is currently insubstantial for specific reasons, some of which are outlined in this article. We argue for psychological activities and their prioritisation to be equally driven by the professional values embedded in clinical psychology and to seek user input in key activities. These values include critical engagement with research literature, theoretically informed question and problem formulation, development of interventions to boost health and well-being, honouring of personal agency, equality and diversity, team development facilitation, psychological education and training for non-psychologists, audit and research that can benefit patients and contribution to social change. We outline target areas that reflect these values and, where possible, draw on empirical evidence developed in diverse sex development (DSD) and other clinical contexts to support our recommendations.


The beginning of the Geothermal Research Program, its organization, objectives, fiscal history, accomplishments, and present emphasis. The projects of the Geothermal Research Program are presented along with a list of references.


Bortezomib also known as Velcade is indicated as a parenteral agent in the treatment of multiple myeloma. In noncomparative trials in multiple myeloma patient's early treatment was associated with a greater rate of success. Treatment with Bortezomib-based regimens was associated with improvements in health-related quality of life. Orthopaedic surgery for spinal cord compression in patients with multiple myeloma was generally predicted to be cost saving, relative to not having surgery, over the medium to long term in modelled cost analyses from a healthcare payer perspective in the UK and US. The initial cost of surgery was high, but the difference in costs between patients undergoing or not undergoing surgery was predicted to decline over time, as savings were realised from the decrease in the number of thrombocytopaenic episodes requiring treatment in patients who underwent surgery.Available pharmacoeconomic data from several countries including the Cochin Cancer Research Centre in Kerala State, India despite inherent limitations, support the use of Bortezomib in the first line treatment of multiple myeloma. Cite this article as: Prem Ravi Varma PK, Sinimol VG, Siji P Jose, et al. 2020. Pharmacoeconomics of bortezomib a cochin cancer research centre evaluation and review. Int J Hematol Oncol.3: 08-17. Copyright: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright © 2020; Prem Ravi Varma PK


Owing to the limited availability of improved varieties the yield of tomato in mid-hill altitude is very low. Hence identification of improved tomato varieties that are adaptable and high yielding is necessary. Therefore an experiment was conducted at Krishi Vigyan Kendra, Mokokchung, Nagaland to evaluate 5 tomato varieties for their growth and fruit yield using randomized block design with 3 replications under field conditions. Data were collected on growth parameters and yield components including plant height, number of branches, fruit length, fruit girth, fruit weight and total fruit yield per hectare. The study indicated that yield per hectare was highest in Megha-1 followed by Sel-1, Punjab Chuara and Sel-2. The lowest yield was obtained in Pusa Ruby. Considering yield and yield components variety Megha-1was found to be the best among all the varieties while the variety Pusa Ruby was the poorest performer for all the parameters. This investigation led to infer that Megha-1 was the bestperforming variety with high tolerance to fruit borer infestation and therefore it could be recommended for commercial production.


In type 2 diabetes the concentration of glucose in the blood is increased, and tissues like fat and muscle become less sensitive to insulin. These two phenomena are interrelated, but since the glucose-insulin interplay is highly complex, many aspects are still not understood. Here, a model-based approach might help. Nevertheless, also a model-based approach has a limited impact, unless models for the sub-systems can be combined into a model for the whole-body regulation. Such a multi-level, module-based model is referred to as a hierarchical model, and this thesis is a proof-of-principle study for the future development of such models. We have extended one of the best available models for the whole-body regulations, to include a zoomable module for the fat tissue. The first step was to implement the wholebody model in the software MathModelica, which support hierarchical modeling. Second, the originally merged insulin-responding module was sub-divided, so that a fat tissue was singled out. Third, a model for the input-output profile for the fat tissue was developed by combining mechanistic knowledge with existing and novel data from human fat cells. Finally, this detailed model was fitted to the profile of the original fat model, and inserted in the whole-body model, with negligible effect on the whole-body simulations. The resulting model has the ability to translate mechanistically oriented simulations on the biochemical level, which is the level were drugs act, to the whole-body level, which is of clinical interest. This is a quantum leap forward for modeling, and understanding, glucose homeostasis and type 2 diabetes.


Partial deficiency of Δ5–3βhydroxysteroid dehydrogenase (3β-ol) was found in a 17-yr-old female with acne (onset at 8 yr), male-pattern hirsutism (beginning with feminization at 12 yr), and primary amenorrhea. Clitoromegaly, but not genital ambiguity, was found. Disproportionate elevations of Δ5–3βhydroxysteroids were demonstrated in all adrenal and ovarian steroidogenic paths. Plasma 17-hydroxypregnenolone (17-Preg) was 32,225 ng/dl, dehydroepiandrosterone (DHA) sulfate was 1,211 μg/dl, DHA was 7,853 ng/dl, and androstenediol was 406 ng/dl. These levels were all over 5 times greater than those of their immediate Δ4–3 keto-me abolites; the latter were nevertheless elevated (e. g.17-hydroxyprogesterone was 3,016 and androstenedione was 493ng/dl). Pregnenetriol and pregnanetriol excretion were 322 and 54 mg/day, respectively, patterns characteristic of 3β-ol deficiency. ACTH stimulated 17-Preg and DHA, though the plasma cortisol level (8.3 μxg/dl) did not rise. Dexamethasone administration reversed all of t...


Abstract
Purpose
While scholars discuss the theory of "Business Ethics," students grapple with applying those theories to hypothetical case studies and business people struggle to live business ethics in practice. Many fail, casting large and ominous shadows. We are inundated with their stories. We need to hear more often stories of those who have succeeded and why their examples are important to the field of Business Ethics.

Design/methodology/approach
This chapter, after providing a brief overview of the differing uses of the term, Business Ethics, expands upon the metaphor of "ethical space" as the eye of a moral hurricane, provides diagrams illustrating the formation of ethical space in a business behavioral context, applies those diagrams to the examples of Andersen and Feuerstein as moral exemplars, discusses ways to mitigate the shadows that eclipsed their example, and suggests ways to enlarge corporate ethical space.

Findings
Ethics is a habit learned through mentoring and developed through practice. In a world of conflicting influences, we each carve out our own ethical space that can serve as an example to others as they face their own individual ethical challenges, but at the corporate level, a moral exemplar will inform the larger corporate ethical space only when the leadership of the corporation consciously adopts and constantly reinforces the example of its moral exemplar.

Originality/value
This chapter uses the visual metaphor of the eye of a hurricane to discuss the formation and importance of ethical space to moral exemplars in a world of conflicting influences and moral pressures.


Modern-day VLSI circuits face the matter of power dissipation not only in design phase but also during testing phase. The significant parameters to be optimized for complex System on Chip (SoC) are test power, test time, area overhead. Scan architectures are most widely used in testing of such SoCs. The main problem in Design for Testability (DFT) is high power consumption. Switching of scan cell creates excessive power consumption. Excessive power consumption may lead to performance degradation and reliability issues. In scan-based testing, the combinational block is consumed major portion of total test power. A modified DFT scan cell is proposed to reduce switching activity in scan cell and to avoid charge sharing problem by modifying a scan flip flop. During shifting, it is able to reduce the power consumption within the scan cell as well as mask the unwanted signal transitions in the combinational part. The experimental result shows that 5.42% to 40.77% improvement in power consumption compared to existing gating approaches.


The paper gives a concise description of Henanese food from four aspects: history,nutrition,cookery and ways of maintaining good health. Typical and various Henanese dishes,plus the most favorable Henanese dishes chosen formally,are demonstrated to be translated into English. Strategies for the translations of all these dishes are offered and explained.


In this review of research on Latin American educational costs and policies, the paper discusses the available use of alternatives for a better use of resources. He shows that a more active role by the private sector will help meet the increasing demand for educational expansion. The paper emphasizes that change will result only from policies applied over the long term.


The technology of processing fresh fruit and vegetable into powder directly extends the storage period,reduces the loss and costs during postharvest, transportation, packaging, and expands the range of applications. The fruit and vegetable powder is becoming more popular in the processing industry recently. In this paper, the application of fruit and vegetable powder in drink, food, and health care were described., Furthermore,based on the previous studies, the problems and prospects of its application were presented.


Results of the complex examination of 7 patients aged from 9 to 16 years with giant cell maxillofacial tumors were analyzed. The CT findings allow one to suppose histological version of the lesion before its verification as well as to estimate adequately the extent of the tumor involvement.


The Social Justice Research Group, University of the West of England, Bristol (UWE) is undertaking a comprehensive programme of work in relation to Children's Social Care (CSC) service provision, budget management and possibilities for new technologies and innovations. The work is funded by grants from the Economic and Social Research Council and the Nuffield Foundation.
Our findings help to answer the questions as follows:
1. Is the funding for local authorities' children's services sufficient to enable local authorities to fulfil their statutory duties?
In short, yes, but not in the current policy framework. There are viable alterations to the framework that will alleviate the perceived crisis in CSC funding. Our research suggests a means to achieve this.
2. What are the financial challenges for local authorities' in providing non-statutory services?
a) The biggest financial challenge is the requirement to ensure that statutory services are delivered on budget, to time, and to an acceptable standard. In this regard non-statutory services are a 'poor relation' and may therefore be required to work with precarious and uncertain budgets from year to year.
b) The decision to provide a non-statutory service may be multi-factorial and the cost-benefit analysis for each service is likely to be complex. In the current climate of 'innovation' there is no shortage of potential services, so the challenge will be to ensure that funded non-statutory services prove they provide return on investment by an objectively robust measure, that they are demonstrably improving lives and not (as an unintended by-product) causing harm.
3. How can funding for children's services be made more sustainable in the short and long term?
As noted above in 1. Our research programme is providing answers to this complex question. A full explanation is outside the scope of this report but available on request. In summary, the question of short-term sustainability poses a more challenging question than long-term issues. The removal of services, particularly those provided for profit will ensure a more stable position whilst long-term changes to the policy framework are implemented. In the long-term, if the recommendations from our research are taken up, we will provide a review and re-triaging of how statutory services are delivered. This will release the budget pressure.
4. How can innovative approaches to the design and delivery of children's services support financial sustainability?
We agree with the concept of an 'innovative approach' but advise that the use of the term 'innovation' in CSC has more than one meaning and operates at numerous points in the primary, secondary, tertiary and quarternary stages of CSC service delivery. Rather than continue to fund increasing numbers of piecemeal individual, profit-making 'innovations' we recommend the use of a wholesale innovative redesign of CSC and their budgets with provision of 'gold standard', research-backed innovation, together with an ethical charter. Our research provides a suggested new policy framework, with focus on financial and welfare outcome sustainability within the current legislation. We suggest policy and practice re-organisation within the available space and budget, together with provision of the national and local level 'dashboard' we are funded to scope in order to monitor critical points in CSC that indicate adverse budget, welfare or legal outcomes.


In this paper practical applicability of stressed oil volume theory in a transformer insulation design process is analysed. For this purpose, lightning impulse (LI) stresses on winding edge are taken as an example and experimental research is performed to verify assumptions made in a previous work. Also, theoretical problems regarding stressed oil volume definition are illustrated.


Automatic physiological control of a moving-actuator type totally-implantable artificial heart occupies a pivotal position for clinical application. We developed a fuzzy logic and knowledge based automatic physiological control algorithm. The fuzzy logic used belongs to the velocity-type fuzzy P control, and the other parts were constructed from expert knowledge most of which have the IF-THEN forms. In vitro experiments were carried out, and we verified the good performance of our developed control algorithm.


This paper presents an FPGA-based real-time simulation model of the dual active bridge (DAB) converter employing a silicon carbide (SiC) MOSFET dynamic device model. The threshold-based model utilizes the Shichman and Hodges equations with voltage-dependent non-linear device capacitances to obtain an accurate model for the turn-off switching transients of the device. The switching transient dictates the rise and fall times of the DAB inductor voltage and output current and it will also be reflected in the output capacitor voltage ripple. Key device states - such as drain-source voltage, drain-current and turn-off delays - and converter states - such as the leakage inductor voltage and output capacitor voltage ripple - can be realized in real-time and monitored with an analog to digital converter in the FPGA board. Such models are beneficial for rapid and cost-effective manufacturing of high-power SiC-based converters such as the DAB. The simulation results are verified experimentally on a 3.3kV/750A SiC MOSFET module, showing good correspondence.


In this work, the ciliary area in the cerrado in five streams belonging to the urbanized microbasin of the municipality of Gurupi - TO was studied with the following objectives: to adjust mathematical functions (logarithmic, exponential, hyperbolic, linear and nonlinear) for determination of probability density functions because they are used as a signature of the ecological processes that occur in the forests, as well as to determine the floristic similarity. It is observed the results expressed by the frequency graphs, the J-inverted formation, with a small perturbation between the initial and intermediate diametric classes, indicating the presence of anthropic actions. The functions were selected by the values of R²aj, Syx%, graphical analysis of the residues and value of F, being: y = exp (25,581 + (- 60,611) / x + (- 6,184) * ln (x)) for Free Water, y = x / (0.639 + -0.084 * x + 0.004 * x ^ 2) for Two Brothers, y = 124.243 * exp ((ln (x) -2.559) 2 / (- 0.379)) for Mutuca, y = 1 / (0.0001 * (x + (- 15.250)) 2 + 0.020) for Medium Lacking I and y = (0.477 + 0.313 * x) / (1 + (- 0.121) * x + 0.004 * x ^ 2) for Pouso do Meio II. The FDPs selected for DAP estimates are accurate and can be used in other areas of the same plant typology. There is floristic dissimilarity between the streams and also within the streams.


Hitler's campaigns in the East, accompanied as they were by unwonted barbarities and atrocities, provoked violent reactions and commensurate suffering for the Germans of the East, innocent and guilty alike. As the Soviet armies advanced, thousands upon thousands of Germans, along the whole front from the Baltic to the Balkans, fled westward in terror. Most of the thousands who remained behind were abruptly torn from their homes and driven west with the willing help of the Poles, the Czechs, the Hungarians, and others. For all practical purposes, by the time of the Potsdam Conference, East Europe was rid of its German minorities. In confirmation of this, the Soviet armies stood, menacing, upon the Elbe and the Danube.


This exploratory study examined the leisure motivational orientations of adults with alcohol and drug addictions. The Leisure Motivation Scale (Beard & Ragheb, 1983) was used to assess the motivation of persons with addictions to participate in leisure activities. Motivational orientations assessed were intellectual, social, competence mastery, and stimulus avoidance. The specific motivation orientations were examined according to the demographic factors ofage, gender, educational level, and primary drug of choice. Older participants reported a higher competence-mastery orientation than younger participants. Those participants whose primary drug ofchoice was alcohol had higher intellectual leisure orientations than those whose primary drug of choice was cocaine. Differences also existed between men and women, with men identifying higher levels of competence-mastery, social, and intellectual orientations than women. Findings of this study suggest considerable variation in the motivational orientations of adults with alcohol and drug addictions.


The connection-coefficients control is a new control model, which is proposed for regulating connection coefficients of the state variables the subsystems of the interconnected systems. It is the direct regulations for the connections of system states and is different from the traditional feedback compensation. This paper is focused on the Connection-Coefficients Synergic Stabilization Problem of a special class of interconnected systems. Then, Linear Matrix Inequality (LMI) controller design method is given for the general case of Connection-Coefficients Synergic Stabilization Problem by using Lyapunov method.


Purpose: The study reviews the knowledge management challenges faced by innovative start-ups founders and entrepreneurs. Knowledge management is critical for innovation, since both organizations and individuals face very specific needs: collection of a wide variety of information and data, such as market data and technical information, and a wide range of transformation of these data into applicable knowledge, in the forms of required product specifications, business model, and business strategy. In addition, the business financing and investment ecosystem (especially Banks & Venture Capitals) uses a traditional "business plan" approach for evaluating innovation companies. Furthermore, a wide range of tools (databases, online information, Collaboration Systems, Business Intelligence Systems, ERP & CRM Systems) enable information flow and supports decision making process. Design/methodology/approach: To this respect, both academic literature and business experience highlight the need to improve Knowledge Management process both for individuals and organizations engaged in Innovation management. Findings: The proposed framework provides academics, entrepreneurs and venture capital companies a new approach for identifying critical success factors knowledge management and further improves decision making in a changing and challenging business environment. Finally the study highlights key areas for further research. Research limitations/implications: This paper is a framework, so the result is in conceptual stage only. Practical implications: This framework is able to adopted by researchers. Originality/value: This paper if original. Paper type: Conceptual paper Keyword: Start Ups, Knowledge Management, Market Analysis, Product Mapping Received: April 28 th , 2020 Revised: September 4 th , 2020 Published: September 30 th , 2020


Biotic homogenization (BH), a process by which β‐diversity erodes, represents a severe threat to biodiversity. Wetland plant communities may be especially susceptible to BH; however, this process has rarely been quantified and represents just one of many possible outcomes of compositional change. Likewise, few studies have used more than two timepoints to investigate BH as a dynamic temporal process. To address these issues, we quantified changes in β‐diversity amongst 48 herbaceous emergent wetlands across a landscape over four timepoints from 1997 to 2015. Pairwise occurrence‐ and abundance‐based dissimilarity metrics were used to quantify β‐diversity. Nonmetric multidimensional scaling was used to map these changes in compositional similarity through time, and repeated measures ANOVA via randomization was used to test for a significant effect of time on β‐diversity. Results indicated that herbaceous emergent wetlands homogenized in Illinois over 15 years due to the increased presence and abundance of Phalaris arundinacea and the decline of several other species. Temporal dynamics of β‐diversity differed between occurrence‐ and abundance‐based analyses. Synthesis. Using both presence–absence and abundance data to investigate BH helped avoid underestimating the impact of BH on β‐diversity, and drew attention to different temporal dynamics in β‐diversity at these two resolutions of community structure. This study highlights challenges associated with investigating BH, such as problems documenting the process where homogenization is not occurring in every site in a region, or where sites are converging towards more than one homogenized state. Incorporating concepts like alternative stable states may be helpful in resolving these issues, and present a more realistic picture of ecological change.


In this study, the aim was to provide the heating need of a detached house from the solar energy in Isparta. For this purpose, solar energy is stored as sensible heat on the water-glycol with 12 flat plate solar collectors. When the temperature of stored water is over 50 °C, it is directly used for heating the house. When the water temperature in the tank falls below this value it is considered that the temperature increased by a heat pump. Heating needs in the numerical study is calculated monthly based on the standard TS 825. Daily values were estimated from monthly mean values. Heating energy requirement was calculated as 346.12MJ at 19 January. It was the highest value of the year. Water temperature in the tank ranged from 16.5 to 96.1 °C, minimum storage temperature occurred at 6 March while the highest was 20 August. It was seen that June to August there is no need for heating, September to December the heating need provided directly from the storage tank, January to May the heating need is provided with heat pump. It is calculated that COP of the heat pump was vary between 3.78 and 5.54. It was shown with calculations that stored energy is mostly used for heating directly, partly used with the heat pump


Cancer‐related gene expression data mostly originate from unfractionated bulk samples, leading to "expression averaging" of heterogeneous populations. Multicolor flow cytometry (FCM) may distinguish heterogeneous populations based on the phenotypic characterization of single‐cells, but is not applicable for RNA targets. Here, we evaluated the PrimeFlow™ RNA assay, a novel FCM‐based assay designed to measure gene expressions, in two cancer entities with high and low RNA target levels.


Background The aim of this trial was to evaluate the safety and efficacy of oral hydration as a substitute for intravenous hydration after cisplatin (CDDP) administration. Methods The major eligibility criteria included patients with lung cancer, indications for a CDDP-based regimen at a dose of 60 mg/m2 or higher, an age of between 20 and 74 years and adequate renal function. Antiemetic prophylaxis consisted of an appropriate dose of palonosetron, aprepitant, dexamethasone and magnesium sulfate (8 mEq). Five hundred millilitres of commercially available oral hydration solution (OS-1: Otsuka Pharmaceutical Factory, Tokushima, Japan) was used as a substitute for intravenous posthydration. The planned sample size was 46 to reject a proportion of 70% under an expectation of 88% with a power of 90% and an alpha error of 5%. Results Between May and November 2013, 31 men and 15 women with a median (range) age of 65 (33–74) years were enrolled from three institutions. Of these, five received adjuvant chemotherapy, 17 received definitive chemoradiotherapy and 24 received chemotherapy for advanced diseases. The median (range) number of chemotherapy cycles was 4 (1–5). After the first cycle of CDDP administration, none of the patients experienced a creatinine elevation of grade 2 or higher, thereby meeting the primary endpoint. Of the 46 patients, 45 (97.8%, 95% CI 88.2 to 99.9) completed the CDDP-based chemotherapy without grade 2 or higher renal dysfunction. Conclusion Oral hydration can be used as a safe and convenient substitute for intravenous posthydration for CDDP administration at the standard dose. Trial registration number UMIN000010201.


The Dai nationality in Honghe maitains a close historical origin with other Zhuang-Dong groups as Zhuang,Dong,Shui,Bouyei,Li,Maonan and Gelao,etc,which are homologous to the ancient Baiyue ethnic group.The paper focuses on Honghe Dai people's historical origin,group name,migration and the present population distribution.


Nowadays, semantics is one of the greatest challenges in IR systems evolution, as well as when it comes to (semi-)structured IR systems which are considered here. Usually, this challenge needs an additional external semantic resource related to the documents collection. In order to compare concepts and from a wider point of view to work with semantic resources, it is necessary to have semantic similarity measures. Similarity measures assume that concepts related to the terms have been identified without ambiguity. Therefore, misspelled terms interfere in term to concept matching process. So, existing semantic aware (semi-)structured IR systems lay on basic concept identification but don't care about terms spelling uncertainty. We choose to deal with this last aspect and we suggest a way to detect and correct misspelled terms through a fuzzy semantic weighting formula which can be integrated in an IR system. In order to evaluate expected gains, we have developed a prototype which first results on small datasets seem interesting.


(-)-Epigallocatechin-3-gallate (EGCg), a major catechin in green tea, eliminates reactive oxygen species and development of lifestyle-related diseases. However, excessive EGCg intake could induce adverse effects, particularly liver injury. We examined whether optimal dietary doses of EGCg reduces the risk of liver injuries in non-obese type 2 diabetic Goto-Kakizaki (GK) rats by examining gene expression of the proinflammatory cytokines interleukin (IL)-1β, IL-18 and tumor necrosis factor-α (TNF-α) and fibrosis-related matrix metalloproteinases (MMPs) in the liver. GK rats at 9 weeks of age were fed a control high-fat diet or a high-fat diet containing 0.1%, 0.2% or 0.5% EGCg (w/w) for 25 weeks. Expression of mRNA and proteins related to inflammation were determined by qRT-PCR and western blot analysis, respectively. IL-1β and IL-18 mRNA in the liver were reduced by EGCg supplementation at concentrations of 0.1% and 0.1%-0.2%, respectively, but not at concentrations of 0.2% and 0.5% (IL-1β) or 0.5% (IL-18) EGCg. TNF-α mRNA in the liver was reduced by supplementation with EGCg at concentrations of 0.1%-0.5%. Expression of MMP2 in the liver was reduced by EGCg supplementation at a concentration of 0.2%, but not 0.1% or 0.5%. Importantly, IL-18 protein levels in the liver and serum were reduced by 0.1% EGCg, but not by 0.5%. EGCg supplementation at concentrations from 0.1% to 0.5% did not induce increases in the expression of liver injury marker genes, while low doses (0.1%–0.2%) of EGCg in GK rats reduced expression of injury-associated genes in the liver.


Don DeLillo's The Body Artist, published in early 2001, perplexed readers expecting another of his sweeping explorations of politics, violence, and the image world. A decidedly quiet, introverted tale of bereavement and spectral visitation, it seemed a radical and rather slight experiment for this acclaimed novelist. In many respects, however, the novel clearly bears DeLillo's stamp: though shorter and more elliptical than his recent work, it revisits two of his most significant themes. The first concerns the range and perils of privacy. In earlier novels, characters such as Great Jones Street's Bucky Wunderlick and Mao II's Bill Gray retreat from public life to seek a space free from invasion, reemerging only to be recaptured by the systems that had threatened them. The Body Artist similarly depicts its protagonist--a performance artist named Lauren Hartke--withdrawing in seclusion after her husband's suicide and then reemerging through a work of art that at once announces and shapes a new self. The second and more significant theme concerns the nature of identity, and the permeable membrane between behavior and performance. In Running Dog, for example, DeLillo suggests that the ubiquity of cameras has transformed us all into actors under constant observation, even by ourselves; DeLillo's play The Day Room offers a dizzying array of masquerades--actors performing in a play-within-a-play that, we eventually learn, constitutes the play we have been watching--designed both to challenge theatrical conventions and to assess the nature of role-playing itself. The Body Artist re-examines this theme through Lauren's shifting voices and fluctuating identities. Although a journalist character who reviews Lauren's piece, Body Time, comments that it is "about who we are when we are not rehearsing who we are" (110), the novel implies that such a condition may not exist. But The Body Artist is not merely a minor variation on familiar themes. Rather, DeLillo's masterly manipulation of voices--both narratorial and dramatized--enables him in this novel to raise profound questions about the many possible forms of possession and about the relationship between art and loss. It is also his most nakedly emotional work, limning the arc of grief by portraying Lauren's encounter with a visitor who may or may not be an incarnate ghost. (1) Perhaps most importantly, this novel marks DeLillo's most penetrating analysis of the process of artistic generation. As we witness Lauren transmute her grief into a scarifying work of performance art, we come to understand inspiration as a variety of religious experience, a form of ghostly possession. The novel itself embodies the theme of spectral inhabitation by incorporating numerous shades and intertextual echoes: hints of the Gothic (a woman and a mysterious male in a lonely house); allusions to classical Greek myth and drama; nods to the cinema of Ingmar Bergman, with its meticulous examinations of identity (Persona), grief (Cries and Whispers), and the power of art (The Magician); a pinch of Krapp's Last Tape (in both texts a person records and relives moments from the past); and even a dash of Harlequin romance (a woman saved from despair by a male intruder). Yet the novel more than displays these influences; it transforms them through literary ventriloquism. The Body Artist haunts and is haunted, ultimately suggesting that to undertake any work of art is to do just that--to perform an undertaking of the dead that must remain incomplete, and hence simultaneously to exorcize spirits and to honor the deceased, not by embalming and forgetting them, but by permitting them to live again as echoes. This undertaking, paradoxically, revives both artist and audience by bringing into existence new selves residing both inside and outside of the work. The first literary echo is relatively close at hand. The opening chapter, in which Lauren and her husband, film director Rey Robles, prepare and eat breakfast, calls to mind an earlier literary breakfast: the famous repast at 7 Eccles St. …


The influence of Al content and section thickness on the microstructural features and tensile properties of high pressure die cast AM series magnesium alloys is quantified in order to better understand the relationship between microstructure and tensile properties. It is found that with increasing aluminum content, the yield strength increases and the ductility decreases. Increasing the plate thickness results in a decrease in both the yield strength and ductility. The grain size, β-Mg17Al12 phase volume fraction, and solute content are all quantified through the thickness of the plates. It is found that the plates have a skin with increased hardness, due to a fine grain structure. The primary factors affecting strengthening in these alloys, including microstructural variations through the thickness, is accounted for using a linear superposition model. We conclude that yield strength is dominated by grain boundary strengthening and solid solution strengthening effects. The through-thickness grain size and solute concentration were quantified and these variations were found to play an important role in controlling the yield strength of these alloys.


Wine fermentations are conducted by naturally occurring or selected industrial wine yeast strains of Saccharomyces cerevisiae. However, non-Saccharomyces yeasts also occur naturally in fermenting grape musts, especially in the initial stages of the fermentation. It has been speculated that these yeasts can contribute to the overall characteristics of the wine. Generally, it is accepted that Kloeckera apiculata is the predominant non-Saccharomyces yeast species in grape must. However, it was shown previously that Candida pulcherrima was the predominant non-Saccharomyces yeast species in a grape must after sedimentation and prior to inoculation with commercial wine yeast. Subsequently, this yeast was investigated in laboratory and small-scale wine fermentations of Chenin blanc wine. As it could not ferment grape juice to dryness on its own, it was used in combination with a S. cerevisiae wine yeast strain. The effect of SO2, di-ammonium phosphate (DAP), pH and temperature on the growth of C. pulcherrima was also investigated. In combined fermentations, no change in overall fermentation rate or standard wine chemical analyses could be observed in comparison to a control S. cerevisiae fermentation. However, wine production in three consecutive years showed that the wine produced by the combined fermentation was of higher quality than that produced by the S. cerevisiae only.


Carbon emission policies bring new challenges to the enterprise operation and supply chain management, making the decision of management more complicated. With a two-echelon supply chain consisting of one supplier and one manufacturer taken into consideration, the supply chain coordination with buyback contract under different carbon emission policies(carbon emissions tax, mandatory carbon emissions capacity, cap and trade) is researched and compared with the situation of no carbon constrain. The results show that, under different carbon policies, the buyback contract can coordinate the supply chain. The manufacture's optimal order quantity gradually decreases under unconstrained condition, cap and trade, and mandatory carbon emissions capacity, while the buyback price offered by the supplier gradually increase.


This paper compares the performance of carrier-based pulse width modulation (PWM) techniques for symmetrical and asymmetrical six-phase open-end winding drives supplied by two two-level six-phase voltage source inverters (VSIs). The VSIs are supplied by dc link voltages of equal value and isolated from each other so that performance which corresponds to three-level single-sided supply drive topology can be emulated. The considered modulation techniques are level-shifted (PS-PWM) and phase-shifted PWM (LS-PWM) with three disposition variation which are phase disposition (PD-PWM), alternate phase opposition disposition (APOD-PWM) and phase-shifted PWM (PS-PWM). Performance of PWM techniques are compared and evaluated based on Total Harmonic Distortion (THD) of phase voltage and current. Experimental works are carried out to validate the results.


Introduction The complete set of the equations of James Clerk MAXWELL are known in electrodynamics since 1865. These have been defined for 20 field variables. Later Oliver HEAVISIDE and William GIBBS have transformed this equations into the today's most used notation with vectors. This has not been happened without 'background noise', then at that time many scientists – one of them has been MAXWELL himself – was convinced, that the correct notation for electrodynamics must be possible with quaternions and not with vectors. A century later EINSTEIN introduced Special Relativity and since then it was common to summarize MAXWELL's equations with four-vectors. The search at magnetic monopoles has not been coming to an end, since DIRAC introduced a symmetric formulation of MAXWELL's equations without using imaginary fields. But in this case the conclusion from the Special Theory of Relativity, that the magnetic field originates from relative motion only, can not be hold anymore. The non-symmetry in MAXWELL's equations of the today's vector notation may have disturbed many scientists intuitively, what could be the reason, that they published an extended set of equations, which they sometime introduced for different applications. This essay summarizes the main different notation forms of MAXWELL's equations.


Disturbances due to anthropogenic activities, especially Land use/ Land cover change; modifies runoff and sediment transport leading to adjustment in channel dimension. To this effect, the land use/land cover change of Donga River Basin was conducted with the aid of temporal satellite images of 1985, 2000 and 2020 downloaded from the United States Geological Survey (USGS) achieve. An unsupervised classification was carried out in ARCGIS 10.3 where seven classes were generated namely: built up area, cropland, forest, grassland, plantations, water body, woodland and bare surfaces. Descriptive statistics was further used to analyse the data. The analysis revealed that Built-Up Area, Cropland, Grassland, Woodland and Bare surfaces increased by +3.41, +12.37, +2.88, +3.05 and +3.75 respectively; while Forest, Plantation and Water Body decreased by -20.93, -2.47 and -2.1 respectively. The implications of such changes at basin scale are increase sediment generated during agricultural activities which are capable of entrainment by fluvial processes, siltation, flooding, cutoffs, narrowing of geomorphic threshold, loss of anchorage for bank materials making it prone to under cutting, bank collapse, channel widening and loss of life and properties. It was recommended that healthy agricultural practices should be encouraged so as to reduce the amount of sediments generated from farming activities especially on hill slopes. Overgrazing and annual bush burning should be check mated in order to reduce the effect of nutrient leaching and erosion of the top soil. There's also need for land use plan that is in line with ecological principles of the study area.


The New Mathematics and an Old Culture possesses such broad implications for cross-cultural communication that the book could merit the title, The New Messageand an Old Culture. Dr. Gay, an experienced missionary, and Dr. Cole, a psychologist specializing in learning theory, trace the complexities of native thought as it is molded by culture and language. With concrete illustrations from the Kpelle of West Africa, the study REVIEWS 41


In this paper, we give a definition of the LL integral, a LL integral contains R integral and L integral.


KEN have Richards made an error [this in issue] his attempt seems to to have made an error i his attempt to "correct" my analysis [Whalley (1979)] of the Paish argument on taxation of capital gains resulting from interest rate changes. My earlier analysis is unaffected. In the numerical example he presents he confuses the current period price of an annuity paying Cl in consumption units every period into the future as Cjd + r)"1 whereas it is Cj/r. C^l + r)-1 is the current period valuation of consumption in the second period, whereas the case he considers is for a perpetual bond paying interest in all periods. Thus, to take his numerical example: Before the interest rate change C0 = 50,


A watermarking method for spectral images is proposed in this study. Multiwavelets are used in computing the transform domain of a spectral image. The visual, gray-scale watermark is transformed with the scalar wavelet transform and the transformed watermark is embedded in the three-dimensional transform domain of the spectral image. The strength of the watermark in embedding is controlled by perceptual constraints and the reconstruction quality. The experiments indicate, that the robustness of the proposed method against attacks like PCA/wavelet compression is better than in embedding in the transform domain obtained with the scalar wavelets


Substantial research attention has been dedicated to longitudinal studies estimating the relationship between smoking and depression and anxiety disorders over the past two decades. In this issue, Fluharty et al.1 provide a succinct and thorough systematic review of longitudinal studies that have examined the relationship of smoking to depression/anxiety disorders, as well as the relationship of depression/anxiety disorders to smoking. Understanding where the weight of evidence lies in terms of: (1) the direction of effect; and (2) conclusions that can be drawn on the underlying mechanisms of these relationships is critical to moving the field forward. This applies both in terms of implications for clinical treatment and from a public health perspective via the potential impact on tobacco control at a population level. The authors conclude that the results offer substantial, yet somewhat inconsistent, evidence supporting a relationship in both directions while, in contrast, providing relatively little information on possible mechanistic pathways explaining these links. In order to move the field forward both in terms of understanding the direction(s) of these relationships and uncovering mechanistic pathways, there are several new avenues that seem to hold promise. First, depression/anxiety disorders and smoking are not fixed states. Major depression is thought to be episodic, with recurrence in the majority but not all cases, and anxiety disorders tend to be persistent, though level of persistence and age of onset tends to vary widely depending on the specific anxiety disorder. Overall, both tend to wax and wane, remit, and relapse, over time. Longitudinal studies with measurements of both smoking and depression/anxiety disorders at multiple time points over several decades (ideally from early adolescence into older adulthood) could help to capture the truly dynamic and fluctuating relationship of these relations over the life course. Second, the study by Duhde et al.2, also in this issue, as well as prior work on trauma, suggests that various exposures and discrete life events (eg, stress and traumatic events) may interact with other factors to provoke changes in smoking and/or depression/anxiety status over time. A better understanding of the impact of such events on the interactive relationship between smoking and depression/anxiety over time is clearly needed. Third, the potential role of various environmental exposures and individual factors on the relationship between smoking and depression/anxiety may be different in adolescence (the highest period of risk for both) compared with midlife. This point is relevant to the conclusion that results to date are inconsistent, and may provide another explanation. For instance, several studies cited by Fluharty and colleagues found no link between smoking and subsequent depression.3–6 However, these appear to have included either unique samples (eg, medical students) or covered only the period from adolescence into young adulthood. The onset of depression tends to be later than several anxiety disorders (eg, phobias). Therefore, these findings may not be truly null, but merely incomplete in the sense that the relationship between smoking and depression/anxiety may genuinely differ at different stages of life. Fourth, it is reasonable to consider the possibility that there are critical periods from a biological perspective. Exposure to smoking and/or the onset of depression/anxiety disorder at different ages may result in a different neurobiological impact, thereby conferring potentially varying effects on risk of depression/anxiety among those exposed to smoking at specific ages/critical periods, as well as the reverse. More work to understand this dynamic may help shed light on potential biological pathways. Fifth, there are strong links between heavy alcohol consumption and/or consistent drug use and mental health problems,7 and these behaviors are common among smokers.8 While many studies adjust for alcohol and illicit drug use disorders, fewer have adjusted for exposure to heavy drinking and/ or consistent drug use that does not meet diagnostic criteria. Sixth, many studies lack ethical/racial diversity (many are drawn from populations of predominantly Northern European descent) and therefore relatively little is known about the potential heterogeneity of these relationships across demographic subgroups. As we see increasingly strong patterning of smoking prevalence by socioeconomic status, and among vulnerable subgroups, exploring this heterogeneity may shed new light on differences in the relationship between depression/ anxiety disorders and smoking by various subgroups. In addition to these important directions, several promising findings are reported in this issue that could help to address the question of causality between smoking and depression/anxiety. Tidey et al.9 found a decrease in depressive symptoms among those with higher depression symptoms at baseline which is consistent with longitudinal work in the population suggesting that quitting smoking leads to decreased recurrence of depression.10 Further, their study isolates a potentially causal agent in nicotine. The use of reduced nicotine cigarettes in future work seems promising toward further understanding potentially causal pathways between smoking and depression/anxiety. Second, Mendelian randomization studies may also be useful in next steps as a promising and intriguing avenue. In this issue, Skov-Ettrup et al.11 did not find a link suggestive of a causal relationship between high tobacco consumption and increased risk of psychological distress, consistent with previous work using this approach.12 However, this could be related in part to examination of psychological distress, which is related to mental health, although it is not an anxiety or mood disorder, per se. As such, use of this method with full diagnostic measures of mental disorders would be of interest as a next step.


Under the background of innovation and entrepreneurship (IE) driving economic development and transformation, it is of great significance to cultivate talents who dare to innovate and have the ability to IE. By stimulating IE potential of college students and improving their willingness to IE and on the basis of understanding the current situation of college students' IE, we explore the relevant factors affecting the willingness of college students to innovate and start a business. From two aspects of internal and external factors, this paper divides the modules that affect IE intention of college students into individual characteristics, self-awareness, school education, and environmental factors. Then, we use the analytic hierarchy process (AHP) to calculate the weight value of each influencing factor so as to determine and analyze the key influencing factors. Finally, according to the existing problems of college students' IE, we put forward countermeasures and suggestions to improve IE willingness of college students from the perspectives of school education and government policy.


Advances in neural network language models have demonstrated that these models can effectively learn representations of words meaning. In this paper, we explore a variation of neural language models that can learn on concepts taken from structured ontologies and extracted from free-text, rather than directly from terms in free-text. This model is employed for the task of measuring semantic similarity between medical concepts, a task that is central to a number of techniques in medical informatics and information retrieval. The model is built with two medical corpora (journal abstracts and patient records) and empirically validated on two ground-truth datasets of human-judged concept pairs assessed by medical professionals. Empirically, our approach correlates closely with expert human assessors (≈0.9) and outperforms a number of state-of-the-art benchmarks for medical semantic similarity. The demonstrated superiority of this model for providing an effective semantic similarity measure is promising in that this may translate into effectiveness gains for techniques in medical information retrieval and medical informatics (e.g., query expansion and literature-based discovery).


A series of oligomeric and dendritic liquid crystalline materials combining mesogenic bent-core units and silicon-containing linking units (siloxanes and carbosilanes) was synthesized and investigated. The influence of the size and shape of the silyl units upon the mesophase type and the switching behaviour was investigated. Linear oligosiloxane based dimers and dendritic carbosilanes show ferroelectric and non-classical antiferroelectric switching monolayer smectic phases with dark conglomerate textures coexisting with achiral domains, whereas cyclic oligosiloxane and silsesquioxane derivatives have antiferroelectric switching and birefringent smectic phases with double layer structure. It is concluded that ferroelectricity and layer distortion require a certain size of the silyl groups and a monolayer structure where each layer is decoupled by sublayers formed by the silylated units.


• Page 1 of 4 • Katyal and Tewari. J Clin Nephrol Ren Care 2020, 6:054 Citation: Katyal A, Tewari R (2020) Crescentic Glomerulonephritis with Tubercular Lymphadenitis. J Clin Nephrol Ren Care 6:054. doi.org/10.23937/2572-3286.1510054 Accepted: July 27, 2020: Published: July 29, 2020 Copyright: © 2020 Katyal A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Crescentic Glomerulonephritis with Tubercular Lymphadenitis


This paper analyses the relationship between investment in Information and Communication Technologies (ICTs) and Technical Efficiency (TE). It uses a panel dataset of Italian manufacturing firms during the period 1995-2003. In contrast to much of the existing literature which focuses on the impact of ICT on labour or multifactor productivity, the paper analyses the relationship between ICT and TE using a stochastic frontier approach. Results show that ICT investment is positively associated with productivity and efficiency, but that the elasticities are lower than those associated with non-ICT capital and labour. Moreover, ICT investments have a positive effect on firm TE, and the impact of ICTs reduces firm inefficiency with a strong time lag since their adoption. Finally, the paper makes a methodological contribution by showing that a Cobb-Douglas production frontier is rejected in favour of a translog one.


FIELD: construction. SUBSTANCE: panel, uppermost a floor panel, is arranged with a core from a wood chip material or a mixture of wood chip and polymer material. The panel comprises a lower lock element arranged on the first side edge, which has the first transverse rib arranged on the lower side of the panel protruding beyond the first side edge, and the first hook arranged on the outer end of the first rib with a rear cut, and an upper local element arranged on the second side edge opposite to the first side edge, and the upper element has the second transverse rib arranged on the upper side of the panel protruding the second side edge, and the second hook arranged on the outer end of the second rib, which has at least one fixing collar, so that two identical panels are arranged as capable of connection and fixation to each other in horizontal direction and vertical direction after clicking of the fixing collar of one panel in the rear cut of the second panel. At the same time in the first transverse rib of the lower lock element there is at least one through groove with width smaller than the width of the second hook. EFFECT: improved reliability of panels jointing. 15 cl, 7 dwg


Thicker thickness materials are employed mostly in heavy constructions, vehicles, and industries, when assembly is suggested various procedures can be proposed for their joining. Gas metal arc welding (GMAW) is still the most attractive welding technology applied in many industries, mainly due to an excellent performance, usability, and competitiveness. In thicker structural steels, multipass welding is usually performed. Defects and discontinuities are generated between the application of each bead, since the heat input in each pass easily affects the microstructure and, therefore, the reduction of mechanical properties, which could be controlled by optimized parameters. Contrarily, a double-wire GMAW can be applied, as an alternative welding technology, in order to reduce the cycle time in bevel-type welding, obtaining secondary benefits. In this work, conventional and double-wire GMAW welds were performed using a structural steel, employing the same power source with some modifications in the torch for double-wire welding, up to 25 mm thickness, where welding bead was satisfactory and obtaining more than 70% of penetration, achieving good heat input stability at double-wire samples. Graphical abstract


Comparable climatic conditions on both coasts of central Florida resulted in cold induced fish mortalities from 19 January to 13 February 1977. Lethal temperatures, the species killed and their relative numbers killed are compared for the Indian River lagoon, Tampa Bay and Sanibel Island estuarine systems. Fifty-six species were killed in the Indian River area, 36 in the Tampa Bay area, while 19 died at Sanibel Island. The higher species mortality in the Indian River lagoon may be attributed to local hydrological and topographical conditions-and a richer ichthyofauna. Cold-induced mortality was noted in both juvenile and adult tropical fishes. Some tropical species appear to be more eurythermic than others as lethal minimum temperatures ranged from 6 to 13 C. Hypothermal stress and mortality were observed in offshore reef fishes. Prior cold mortality accounts from the literature combined with the current study reveal that a total of 132 fishes have suffered cold mortality in Florida


Chronic granulocytic leukemia developed in a 59–year‐old woman who had previously received a total of 21 mCi 32P for polycythemia Vera. She was treated with Myleran (busulphan) for her chronic granulocytic leukemia. Cytogenetic studies revealed deletion of chromosomes No. 8 and 12, and translocation between 1 and 8. The patient also developed a severe autoimmune hemolytic anemia, for which she received prednisone treatment. She died with a perforated stomach ulcer.


The results of in vitro hematopoiesis studies have provided most of the knowledge about the organization, regulation, and development of the human hematopoietic system over the past three to four decades. However, due to the impossibility of an appropriate assessment of hematopoietic stem cells (HSC) in humans and because of the shortcomings of methodological approaches to determining the role of hematopoietic progenitor cells in the pathogenesis of MDS and to predicting the course of the pathological process, semiliquid agar cultures of bone marrow from patients with myelodysplastic syndrome were used. Myelodysplastic syndrome (MDS) refers to a clinically, morphologically, and genetically heterogeneous group of diseases characterized by clonalism and arising from mutations at the level of hematopoietic progenitor cells. Proliferation of such a mutated stem cell progenitors leads to ineffective maturation of myeloid lineage cells and dysplastic changes in the bone marrow (BM). The aim of the study was to establish the relationship between the functional activity of hematopoietic progenitor cells in the ex vivo culture and the activity of the pathological process in the myelodysplastic syndrome. We studied bone marrow samples from patients with the myelodysplastic syndrome, namely refractory anemia with excess blasts I (MDS RAEB I) and refractory anemia with excess blasts II (MDS RAEB II) and AML under conditions in vitro, as well as their clinical laboratory data. It was found that the percentage of blasts and myeloblasts in the samples of patients with AML and MDS RAEB II increased, compared to the samples of patients with MDS RAEB I (63.5±3.9 %, 18.05±1.01 % and 9.49±1.53 % respectively). An increase in the number of erythrocytes and hemoglobin content was noted in the group of patients with MDS RAEB I compared with MDS RAEB II (2.9±1.4×1012 / l and 105.04±3.6 g / l versus 9±0.8×1012 / l and 84.5±4.8 g / l, respectively). The analysis of the results of BM studies of patients with MDS in in vitro culture indicated a significant lag in the formation of cell aggregates during cultivation and a pronounced inhibition of the colony-forming ability of progenitor cells, compared to the control. A noticeable decrease in the colony-forming ability was observed in patients with MDS RAEB I, MDS RAEB II and AML in this sequence – 4.1±1.2 per 1×105 explanted cells, 3.2±0.9 per 1×105 explanted cells and 2.0±0.6 per 1×105 explanted cells, respectively. The analysis of hematological parameters and the results of BM cells cultivation at different stages of MDS indicates that the colony-forming ability of progenitor cells correlates with the depth of the pathological process.


The purpose of this paper is to implement an application in LabVIEW programming language which logs the measurements from photovoltaic (PV) inverters. The application's communication module is connected to the inverters of the PVs via the Modbus TCP/IP protocol and collects the measurements of appropriate process quantities, such as the active power, the total electricity produced, the panel temperature, the insolation, the air temperature, etc. Furthermore, all the collected measurements are saved on a 15-minute basis in separate csv files for each day. Additionally, a graphical user interface (GUI) is developed, where the collected measurements from the PV are displayed. The PV for which the application is developed is located on the roof of the building B of the University of Zagreb Faculty of Electrical Engineering and Computing (FER).


The phase detection in cholesteryl oleyl carbonate was studied over a broad temperature range by dielectric spectroscopy. Tests were conducted in the static and the low frequency ionic regions. They point to the possibility of relatively simple detection of phase transition. Some manifestations of pretransitional behaviours were also found. - Pacs: 64.70Md, 77.22Ch, 64.30+t


Excitonic optical properties of GaN have been studied by means of time-resolved nonlinear luminescence spectroscopy, which was based on an excitation correlation technique under excitation at which a transition of the dominant radiative recombination process occurred from donor-bound excitons to biexcitons. Nonlinear luminescence observed at a donor-bound-exciton line resulted from the superposition of three components: a faster-decay component of a superlinear signal, a slower-decay component of a sublinear signal, and a positive base; that is, a much slower-decay component of a superlinear signal as compared with the time range employed in the present measurement (∼600 ps). The sublinear signal was attributed to the state-filling effect of donor-bound excitons, and the positive base was attributed to the saturation of nonradiative recombination centers. In addition, the superlinear signal was attributed to the stimulation of biexciton luminescence, which appeared close to the donor-bound-exciton lumines...


During the pandemic caused by the SARS-CoV-2 virus, healthcare workers are at the forefront of the battle undergoing not only significant physical but also emotional stress. At the same time medical workers are considered to be at high risk for the incidence of COVID-19. Staying in a state of constant emotional stress over time leads to the emergence of both mental and somatic disorders. The purpose of this article is to conduct a literature review on the principles of consistency regarding the mental health of staff members of medical institutions providing care to patients with COVID-19. A systematic literature search has been carried out, as a result of which 32 articles with reports of mental and behavioral disorders during the pandemic have been selected for analysis. The main group of disorders are disorders of the anxious-depressive spectrum. According to various sources, from a quarter to a third of medical workers have clinically significant anxiety, about a third – depression. Significant prevalence of sleep disorders in individuals providing medical care to patients with COVID-19 has also been indicated. In the long term, the expectation of an increase in the level of post-traumatic stress disorder has been indicated. The article also provides modern views on the socio-psychological effects of epidemics and pandemics. Excessive attention, especially on social media devoted to the problem of COVID-19 significantly complicates the fight against the real problem of overcoming the pandemic. It has been proven that overconcentration on problems associated with COVID-19 is a factor of the increased risk of developing generalized anxiety disorder in the end. Thus, the protection of mental health and the socio-psychological support of medical workers are some of the important directions in the fight against the coronavirus pandemic. The management of psychological crises during pandemics should be based on psycho-hygienic and psycho-preventive measures both at the level of the individual and society as a whole.


Ischemia dramatically depletes tissue ATP levels by inhibiting mitochondrial respiration. Timely reperfusion can limit cell necrosis but reperfusion is known to induce mitochondrial permeability transition (MPT) and cyt c release that would further inhibit mitochondrial respiration and promote apoptosis. We have developed a synthetic tetrapeptide (SS‐31) that selectively targets the inner mitochondrial membrane, and improves mitochondrial respiration, reduces reactive oxygen species and inhibits MPT. We have studied the effects of SS‐31 in rats with bilateral renal ischemia. SS‐31 preserved kidney ATP levels during moderate ischemia, and accelerated the recovery of ATP upon reperfusion. EM studies showed that SS‐31 protected mitochondrial structure during ischemia and prevented mitochondrial swelling during reperfusion. Isolated mitochondria studies revealed improved mitochondrial respiration upon early reperfusion. Rapid recovery of ATP helped preserve epithelial cell cytoskeletal architecture, cell‐cell contact, and cell polarity. This resulted in preservation of renal function and minimized inflammation. SS‐31 (Bendavia™) is the first mitochondrial protective compound that can reduce IR injury after ischemia and is in clinical trial for cardiac IR.


The paper develops an Ultrasonic cleaning machine and introduces the designs of its circuit and whole machine,which enhances the cleanliness and cleaning efficiency of parts.


This study applies variation theory to examine the discourse of three online groups learning about the structure and behavior of simple population models. Students' discussions were examined to reveal whether the discussions provided opportunities to become aware of possible variations corresponding to those critical dimensions. The findings indicated that only in Group 1 did the discussion open variations corresponding to critical dimensions of the model structure and growth patterns. We propose that variation theory is useful as an analytic lens for researchers interested in collaborative learning particularly in online environments, and also as an instructional design tool for teachers in designing collaborative tasks.


The rigorousness, professionalism and seriousness of answer contents in social Q&A communities have declined sharply. It is of great significance to tell users how to provide excellent answer contents. The purpose of this research is to explore what features of answer content are more likely to make a high-quality answer. For this purpose, the research, taking "Zhihu" as an example, collects the data of answer contents with a crawler, combines initial analysis of the answer contents with related research literature, and selects 9 features that may have impacts on the quality of answer contents. Then the supervised machine learning method will be used to explore the features that can really affect the quality of answer contents, so as to provide reference for guiding users to provide high-quality answer contents.


Stent is one of the common solution that is offered to the patient with atherosclerosis. An ideal stent should have good mechanical and biological properties. This research aims to analyze how importance strut linker geometry affect mechanical behavior of stent especially on recoil percentage, foreshortening percentage and fatigue safety factor prediction using finite element analysis. The result showed that strut linker geometry would specify the mechanical behavior.