John Locke has been considered one of the leading figures in the His- tory of Philosophy, specially for his two famous treatises An Essay concerning Human understanding and Two Treatises on Government . None the less his work in Pedagogy, Some thougths concerning Education , is no less important, and provides the leading strings of that what ought to be the education of the gentleman, whose unavoidable foundation must be a solid education in virtue grounded in the moral principles of Christianity. Key words : Locke, Moral education, Spanish authors of the XVIth century.


Background: If an HIV-positive woman becomes pregnant, certain complementary nutritional considerations must be justified, since pregnant women with HIV have greater needs to promote a healthy outcome. This review aims to provide information on HIV and pregnancy, nutrition, and infection, and how care and environment can be improved for these HIV positive women. Results: The search yielded a total of 120 articles, of which 102 were excluded by title, abstract, or year of publication. In total, as a result of this search, 20 articles were included, which met at least one of the criteria. Based on the results of the study, these show a great diversity in the changes and recommendations for pregnant women who show the pathology.


Under Presidential Decree No.103 of 2001 on the Position, Duties,
Functions, Structure and Work of Non Departmental Government Institutions,
Finance and Development Supervisory Agency (BPKP) is a government agency that
was given broad responsibilities at the national level to formulate and plan and
control programs, carry out a general control over the central government finances
by providing internal audit on the activities of the state ministries and offices of their
project. BPKP authority does not just end there, BPKP also can perform a special
examination or audit investigation to uncover cases related to abuse of authority
resulting in loss of state or benefit some people. If there are indications of corruption,
the references used in conducting the audit investigation BPKP is Law No.31 of 1999
jo Law No.20 of 2001 on the Eradication of Corruption.
The method used in this research is normative law. Normative legal
research is research that uses methods that refers to the legal norms contained in
legislation and court decisions.
The problem in this research are : First, how authority of BPKP auditor in
calculating state losses in the case of corruption in terms of the regulations?
Secondly, what are the legal aspects review authority of BPKP auditor in calculating
the financial losses in Yogyakarta District Court Decision No.64/PDT.G/2009/PN
YK)?
The authority of the Finance and Development Supervisory Agency (BPKP)
is reinforced by the Constitutional Court Decision No.31/PUU-X/2012 dated October
23, 2012.Such decision reinforces the authority of BPKP to conduct an audit
pursuant to Presidential Decree 103 of 2001 and Regulation No.60 of 2008. When
referring to the explanation above, the action on the authority of the BPKP auditors
calculate the financial losses of the State in case of Yogyakarta District Court
Decision dated January 19, 2010 No.64/PDT.G/2009/PN YK contained in the lawsuit
Point 14 , g , h , and conclusions lawsuit point 14 on the judges verdict is already in
accordance with applicable regulations and according to the law, make the results of
an investigative audit report or at least the calculation of state financial losses made
by the BPKP auditor is valid, correct, professional, legitimate and enforceable.


In this paper we explore the issue of academic incubators performances. We first discuss how and why universities entered the business arena to extract value from the knowledge they were creating. We argue that Universities followed two different strategies: a simple goal versus a mixed goals strategy. This dichotomy has made the issue of measuring performances a tricky one. As far as performances in value extraction is concerned, huge differences exist. We suggest that available input resources are not a full account for explaining such differences. We argue that real commitment, specialization of resources and ability to modify and innovate internal processes can explain these differences. We use the Italian case as a test-bed for these assumptions.


This Internet column reviews Travelmall (URL: www.travelmall.com), a travel agent with a long history of providing online travel service. Similar to other articles in the Internet series written for the Asia Pacific Journal of Tourism Research, this paper presents the background of the website, discusses its contents in terms of service provision and evaluates the website's usefulness from the perspective of users. The paper ends with a concluding section that summarizes the article.


Submitted for the MAR15 Meeting of The American Physical Society Energy band structure of bulk and monolayer vanadium pentoxide (V2O5) beyond the quasiparticle self-consistent GW approximation: lattice polarization effects1 CHURNA BHANDARI, WALTER R.L. LAMBRECHT, Department of Physics, Case Western Reserve University, MARK VAN SCHILFGAARDE, King's College, London — The quasiparticle self-consistent GW method (QSGW) is known to systematically overestimate the band gaps in semiconductors by about 20% due to the underestimate of screening by the random phase approximation (RPA). We show that for V2O5, a layered oxide material, the overestimate is significantly larger. The smallest direct gap in QSGW is found to be 4.83 eV compared to 2.35 eV experimentally. The evidence for the experimental gap and optical properties are reviewed. We suggest that a major contribution to the self-energy reduction results from the lattice polarization contribution to the dielectric screening. This results from the large LO/TO splittings in this material. We make a simple estimate of the reduction of W (q=0, ω=0), and obtain a factor ∼0.38, which if assumed to apply for all W and reduces the gap to 2.60 eV. The remainder of the gap overestimate is tentatively ascribed to shortcomings of the RPA. We also consider the band structure of this material in monolayer form. We find that the GW correction depends strongly on the layer separation (L) as 1/L. The lattice polarization itself depends on distance between the layers because of the dependence of the phonons on the long-range Coulomb interactions and hence reduced screening in a 2D system. 1Supported by DOE, AFSOR, Simons Foundation. Churna Bhandari Case Western Reserve University Date submitted: 10 Nov 2014 Electronic form version 1.4


The aim of the present paper is to simulate the work process of intake valve in reciprocating compressor.To understand the flow, temperature characters and valve plate movement, the Computational Fluid Dynamics (CFD) is used to simulate the process of expansion and suction. In each time step, the fluid motion equation is iteratively solved to obtain the pressure distribution on the valve plate, and the valve plate moving can been determined by solving the valve plate motion equation at the end of time step. The simulation result shows the pressure and temperature field is uniform in cylinder during compressor expansion, but very different in suction process. The valve plate opens from 53.2° to 219.5°, which is well consistent with the theoretical calculation results (56°, 220°). This study identifies that CFD is a valid tool for exactly investigating the flow and valve plate movement.


Native soybean collections were evaluated to search a resistant gene source to purple blotch caused by Cercospora kikuchii. Among 467 native lines, about of the lines was less than and was over in natural infection of purple blotch. Natural infection seemed to be significantly associated with weather conditions at the early podding stage. A significant correlation between natural infection and purple discoloration by seed inoculation was observed and this method seemed to be effective as a preliminary screening technique for resistance to purple blotch. Most of the late maturing native soybeans showed susceptible reaction by the seed inoculation contrary to low infection under natural conditions, indicating that the low natural infection might be due to disease escaping by the late maturing instead of their genetic resistance.


Objective To analyze the results of transcranial Doppler (TCD) and color Doppler flow imaging (CDFI) on the patients with idiopathic Parkinson's disease (PD) and vascular Parkinson's syndrome (VP) and to better understand the pathogensis of the two diseases.Methods 29 cases of VP and 30 cases of PD were evaluated by TCD and CDFI.Results The abnormality rate was 55.17% in VP and 35.18% in PD by TCD, the difference in abnormality rate was significant(P0.05). CDFI also revealed obvious difference in the degree of narrowing of the carotid artery caused by atherosclerotic plaque(P0.05).Conclusion Combined use of the two techniques helps to differentiate VP from PD, and provides clinical evidence to better understand the changes in cerebral hemodynamics in connection with the pathogenesis of the two Parkinsonian disorders.


The working law and method of finding aster technology is introduced that can once finished in field by ~(218) Po radioactive measurement conveniently. The test result successfully proves that the not bleed ~(218) Po method can find water bearing structure crack. On underground water resource reconnaissance. This new technology can gain surey results immediately and trace exceptional condition in field, like γ law and instant (bleed) shoot law, It can apply to different topographtpy and land form, Such as the beach of sandy, desert, swamp just reaped paddy field etc.


The Tc-MIBI has been used with great value as a diagnostic technique in patients with primary hyperparathyroidism. False-positive scans may occur due to misinterpretation of the physiologic distribution of the Tc-MIBI. Reviewing consecutive SPECT scans, we evaluated this possibility and assessed how frequently brown adipose tissue (BAT) is seen on Tc-MIBI scintigraphy. Here, we retrospectively reviewed scans of consecutive patients who were evaluated for parathyroid adenomas from March 2015 to June 2015, using dual-phase (early and delayed) planar imaging and SPECT. We identified 60 patients (48 female and 12 male; mean age, 52.25 15.20 years; range, 22–86 years). We detected the presence of Tc-MIBI uptake in BAT in 20 of 60 patients (33.33%) in the neck. Although the patients with Tc-MIBI uptake in BAT were younger (mean age, 48.85 15.27 years, range, 26–73 years) than the patients with no Tc-MIBI uptake (mean age, 53.95 15.07 years, range, 22–86 years), this difference was not statistically significant (P1⁄4 0.224). The percentage of female patients with BAT detection was higher (17/48 patients; 37.5%) than that of the male population (3/12 patients; 25%), this difference was not also statistically significant (P1⁄4 0.85). In patient population referred to Tc MIBI scintigraphy of the parathyroid glands, uptake of Tc-MIBI in BAT should not be misinterpreted with Tc-MIBI-avid-tumors. Fused SPECT/CT images (not SPECT-only) are necessary to distinguish BAT from bone, muscle, thyroid, myocardium, parathyroids, and other structures in the neck and chest. (Medicine 95(2):e2498) Abbreviations: Tl = Thallium-201, Tc-MIBI = Tcmethoxyisobutylisonitrile, BAT = brown adipose tissue. INTRODUCTION T hallium-201 ( Tl) scintigraphy was the first radionuclide diagnostic method widely used in the 1980s for hyperfunctioning parathyroid localization. For parathyroid localization nd Farinaz Farhoudi, MD et al used Tc-methoxyisobutylisonitrile (Tc-MIBI) for parathyroid scintigraphy. Thallium superseded by the novel radionuclide because of several advantages such as higher energy (that makes it ideal for gamma camera imaging), better dosimetry and higher sensitivity. The subtraction of thyroid images obtained with I or Tc from those obtained with Tc-MIBI is a variation of this method. Taillefer et al found that Tc-MIBI washes out more rapidly from thyroid gland than from hyperfunctioning parathyroid glands, so they suggested the use of a single-isotope dual-phase (early and delayed) scintigraphic method. Tc tetrofosmin also has been used for parathyroid imaging, but the experiential data for this technique are scarce. In some adults, brown adipose tissue (BAT) is metabolically active and can cause false-positive scans due to misinterpretation of the physiologic distribution of the Tc MIBI. Previously, BAT has been detected by some nuclear imaging methods such as single-photon imaging using I-metaiodobenzylguanidine, and by PET using FFDG or Tc-tetrofosmin in humans. Assessment of the visualized body during a Tc MIBI scintigraphy of the heart or parathyroid glands is essential to exclude incidental tumoral uptake, which may be Tc-MIBI-avid. As we know, there has been some new evidence of Tc-MIBI uptake into BAT in humans so, reviewing consecutive SPECT scans we evaluated this possibility and assessed how frequently BAT is seen on Tc-MIBI scintigraphy. MATERIALS AND METHODS


Illumination at various levels in an undisturbed snow cover was measured with CdS cells at intervals during the winter, along with air permeability and density. Extinction coefficients for particular layers increased with time. Measured values in the snow layer near the soil ranged from 0.072 cm−1 to 0.313 cm−1, computed as an average for light in the 0.5 to 0.7-μ region. Coefficients for higher levels varied from 0.059 cm−1 to 0.148 cm−1. A relation between the extinction coefficient, air permeability, and density based on the Carmen-Kozney assumption predicts the observed values with fair accuracy.


Correct prediction of electricity consumption is important for planning its production in the short term, but also in the long term due to the construction of new power plants and mining planning. Accurate prediction is a challenging task because the consumption changes both in the day and during the whole year. The paper describes a method based only on input data for consumption. No additional influences were included such as temperature, wind, GDP (Gross Domestic Product). Five machine learning algorithms were used to create a predictive model. The best results were achieved with a local polynomial regression algorithm. Daily prediction error was 5.77%, weekly 3.49% and monthly 2.41%.


Abstract This paper analyses the nature of collaborative teacher learning as a form of 'public sphere', under current policy conditions. The research draws upon Habermas' notions of communicative action and public spheres, and literature on the nature of teachers' learning in the context of standardized curriculum and assessment reform, to analyse how teachers' work and learning can be understood in light of pressure for increased accountability for improved performance. Drawing upon transcripts of professional learning meetings—referred to as 'Inquiry Cycles'—at a school in northern Queensland, Australia, and interviews with participants, the research reports that while the Inquiry Cycles constituted a 'public sphere' for teachers' learning and inquiry, they were simultaneously influenced by more instrumental policy support for an increasingly prescriptive curriculum, and pressure for improved performance, particularly against standardized measures of literacy and numeracy. The research explores how a public sphere in the form of the Inquiry Cycles was responsive to these more instrumentalist forms of rationality, revealing a need for cautious engagement with such initiatives under current policy conditions, even as they have the potential to effect more productive learning on the part of teachers.


ABSTRACT In this paper, we investigate the conditions under which a diagonal quadratic form represents every integral matrix, where ( ) are integers. For , we give a necessary and sufficient condition. Also we give some sufficient conditions for each where ( ) are pairwise coprime.


We determined the nucleotide sequence of polymerase chain reaction products resulting from amplification of joint regions created after excision of transposons Tn5381 and Tn916 from a single site within plasmid pAD1. For both transposons, two joint sequences were observed. One (ATAGAT) was six nucleotides in length and identical to one of the junction sequences flanking the integrated transposon. This sequence also represents the original target sequence within pAD1. The other (TATGT (Tn5381) or TAGTT (Tn916)) was five nucleotides in length and identical to the junction sequence at the other end of the integrated transposons. These results suggest that excision of conjugative transposons from some insertion sites in gram-positive bacteria results in the formation of a joint region heteroduplex mismatched in nucleotide number as well as complementarity.


Knee joint pain is the most disabling condition mostly associated with ageing. This study investigates the problem of knee joint pain, its severity in 60 patients of age group 45 to 65 years of age, the therapeutic effect of most similimum rare homoeopathic medicines repertorised on basis of comprehensive case taking and individualization to reduce pain, improve mobilization and improve quality of life. Aim: To ascertain the Effectiveness of Rare Homoeopathic Medicines in the management of knee Joint Pain in patient between the age group 45 to 65 years of age. Objective: To evaluate the therapeutic effect of Rare homoeopathic medicines prescribed on symptom similarity to the patients of Knee Joint Pain. Study Design: A pre-post Study. Methods : 60 patients were taken up for this study after being diagnosed with knee joint pain with the aid of history taking, clinical examination, investigation and application of rare homoeopathic medicines. Results: Out of 60 Patients of Knee joint Pain, 8 cases (13%) showed marked improvement, 34 cases (57%) showed moderate improvement, 14 cases (23%) showed mild improvement, while 4 cases (7%) were in status quo and 0 case showed worsening of symptoms. Conclusion : Rare Medicines Angustura Vera, Formica Rufa, Arbutus Andrachne, Osteo Arthritic-Nodosa, salicylic Acid, Sycotic Bacillus are found effective in treatment of Knee joint pain in patients between the age 45 to 65 years of age.


Abstract The utilization of 49 carbohydrates was examined for 134 isolates of Metarhizium anisopliae covering 16 characterized strains, seven isolates of Metarhizium flavoviride var. flavoviride, nine isolates of Microhilum oncoperae , and 30 isolates of Beauveria bassiana using the API50CH system. Using canonical variate analysis five major groupings were discernible: B. bassiana, M. oncoperae, M. flavoviride, and two M. anisopliae groups. The two M. anisopliae groups consisted of a large cluster of M. anisopliae var. anisopliae strains and a group of cold-active M. anisopliae isolates able to germinate at 5°C. Based on this and other data, we suggest that the cold-active group forms a distinct variety of M. anisopliae which we propose to call var. frigidum. Differentiation of the 16 strains of M. anisopliae was possible using the API50CH system and we conclude that carbohydrate utilization is a useful and biologically relevant taxonomic criteria for the separation of Metarhizium strains and other entomogenous fungi.


A dual functional filtration/aeration membrane bioreactor (MBR) coupled with polyethylene micro-porous tubes(MPTs) was studied. PE-1 and PE-4, two types of MPTs with pore size of 70~120μm and 5~10μm respectively, both had a similar specific membrane flux as high as 250 L/m^2•h when tap water was filtered although their pore sizes are different. Permeability of MPTs was largely affected by membrane flux hut less affected by activated sludge concentration. The alternate operation of filtration and aeration could effectively remove cake layer on the membrane surface and keep up the stability of the membrane filtration characteristics. The influences of the alternate operation time T and the initial membrane flux J(subscript 0) on the membrane filtration characteristics were further investigated. When T varied from 0.5h to 3h and J(subscript 0) from 60L/m^2•h to 140L/m^2•h, the average flux J(subscript a) in one cycle declined firstly and then leveled off in the range of 50L/m^2•h to 80L/m^2•h, but the better stability of J(subscript a) was found when J(subscript 0) was smaller. Domestic wastewater was treated by filtration/aeration MBR and the effluent with quality as good as the conventional MBR was achieved even under shock loading. There was no much difference between PE-1 and PE-4 in the performance of COD and NH(superscript + subscript 4)-N removal.


The JEM-X monitor provides X-ray spectra and imaging with arcminute angular resolution in the 3 to 35 keV band. The good angular resolution and the low energy response of JEM-X plays an important role in the identification of gamma ray sources and in the analysis and scientific interpretation of the combined X-ray and gamma ray data. JEM-X is a coded aperture instrument consisting of two identical, coaligned telescopes. Each of the detectors has a sensitive area of 500 cm 2 , and views the sky through its own coded aperture mask. The two coded masks are inverted with respect to each other and provides an angular resolution of 3 0 across an eective field of view of about 10 diameter.


The present invention relates to technical field of coatings, specifically disclose a kind of water-based epoxy zinc-rich primer and preparation method thereof.The priming paint is counted in parts by weight, including the following raw material:Epoxy resin:10-30 parts, wetting dispersing agent:0.1-0.5 parts, antifoaming agent:0.1-0.5 parts, coalescents:1-5 parts, zinc flake:40-70 parts, spherical zinc powder:4-20 parts, ferrophosphorus powder:0-25 parts, graphene oxide:0.2-2 parts, aerosil:0.2-2 parts, anti-flash rusting agent:0.1-0.5 parts, curing agent:10-30 parts, lithium magnesium silicate:0.1-1 parts, deionized water:5-10 parts.Double-component aqueous epoxy zinc rich primer provided by the invention, using A/B components, construction is simple, VOC content is low, and hardness is high, and adhesive force, impact resistance, anti-sag are had excellent performance, and anti-settling property is good, improves the storge quality of coating, and salt fog resistance is had excellent performance.


In Wakayama Prefecture, there is a difference in the altitude reached by settlements situated in the two mountainous areas bounded by the Arita River. In the southern part, all of the impotant settlements are situated along the bottoms of main valleys, higher communities being located at the inner part of the valleys along the affluents of the River. Thus, the height of the settlements in this part of the Prefecture is limited to 40-50% of the altitude of the divide. In the northern part, on the other hand, we can see settlements established not only at the inner part of valleys but on considerably high mountainsides; and there are many important villages no longer situated at the bottoms of main valleys, but elevated to the high hillsides or the summits of high mountains. Consequently, it is not unusual to see settlements rising up to approximately 70-80% of the altitude of the divide.The above-mentioned fact is primarily due to the difference in the configuration of the ground. While mountains are steep in the southern part, there remain at the eminences of the northern part, comparatively much gently-sloping ground of initial form before upheaval. Secondly, orange-growing concentrated in the northern part has played a great part in elevating the settlements up to higt mountainsides. Moreover, it is understandable that the unique city Koyasan of sightseeing and religion center, being situated at the altitude of 840m., has exerted not a small influence upon the rising of the settlements in the northern part of the Prefecture.


Biogeography is the science and study of geographical distribution of biological organisms. BBO is a traditional algorithm that maximises efficiency, based on the mathematical aspects of biogeography. The project aims at sharing the probable features between solutions and fitness values that are represented as immigration and emigration between islands. BBO is similar to biological optimization methods i.e. Genetic Algorithm (GA) and Particle Swarm Optimization (PSO) that carries features which are unique. The proposed algorithm of BBO provides a solution to many that uses GA and PSO. This paper demonstrates a performance of the proposed BBO with a set of well known standard benchmark functions.


Understanding gender differences in fantasy sport consumption involves in-depth assessment of personal attributes, consumption, sport fandom, and motivations to participate. The study addresses the area of gender and fantasy sport, examining motivation and consumption behaviors of men and women concerning this activity. In this research, a total of 530 men and women fantasy sport users were surveyed about their media consumption and overall motivations for participating. Results indicated men consuming nearly 10 hours more of sports media content each week than women. Regarding motivations, men and women yielded consistent motivations for play on five of the seven measures, with the two remaining measures, enjoyment and passing time, being significantly higher for men. Implications and directions for future research in this relatively new scholarly realm are offered.


Issue 44(4) rounds out 2021, a year when everyone thought the world might be further through the COVID pandemic than it is. In an innovative follow-up article, Karen L. Anderson, Margaret E. Pierce, and Kathleen M. McNamara revisit their 2019 study (see JEE issue 42[3], pp. 229-248) and demonstrate that service-learning involvement can have a long-term impact on teachers who participate during their preservice training. Lan Kolano and Anna Sanczyk report on their study of preservice teachers engaged in a service project involving English language learners. [Extracted from the article] Copyright of Journal of Experiential Education is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)


Wireless mesh networks (WMNs) are expected to be one of the next generation of wireless interconnection technologies. As to fully exploit the advantage of WMNs, a lot of research work has been done, e.g. new routing protocols, metrics, multiradio/multichannel WMNs, etc. In this paper we present a multiradio WMN testbed (called MR mesh) which was designed with purpose to study different routing protocols, metrics and channel selection/assignment algorithms or other strategies. MR mesh implements mesh functionality upon multiple 802.11 based wireless network cards. It is flexible to support different routing protocols, metrics, easy to implement channel assignment or radio selection algorithms, and simple to experiment network organization/management strategies.


Relationships between the composition of 2,4-D solutions and their effectiveness as
 herbicides were investigated. The measure of effectiveness was the reduction in fresh
 weight of the growth above the primary leaves of bean plants. Two methods of application
 were used: the drop method (0.01 ml of solution) and the spray method. Variables studied
 were: diluents, humectants, surfactants, types of amines and esters, concentration,
 and dosage. Other studies included the effect of point of application on effectiveness
 and on the distribution of radioactive 2,4-D in the treated leaf and in the plant.
 For comparative purposes, some similar studies were conducted with radioactive aminotriazole
 and maleic hydrazide.


This note provides information on Six Sigma and business improvement at Dominion Resources, Inc., including many examples of the CEO Tom Farrell's personal commitment and support. It can be used in executive education leadership programs and business courses in operations management in discussions about Six Sigma program elements that help sustain a culture of continuous improvement and deliver extraordinary business results. Ten years after its launch at Dominion Resources, Inc., Six Sigma, is one of the nation's most widely recognized initiatives having been cited for audited hard savings, integration into corporate culture, percentage of employees trained, sustained management support, and employee recognition.

Excerpt

UVA-OM-1453

Sept. 2, 2011

SIX SIGMA AT DOMINION RESOURCES, INC.:

INVESTING IN EXCELLENCE

I firmly believe that Six Sigma provides us with a clear pathway to excellence in everything we do—and how we do things every day.

—Tom Farrell, CEO of Dominion Resources

. . .


A lectin with hemagglutinating activity has been isolated from an aqueous extract of the symbiotic phenotype of Dictyonema glabratum and its cyanobacterial photobiont Scytonema sp. The purified lectin had a pI of 6.8 and its molecular mass was investigated by electrospray ionization mass spectrometry, gel filtration and SDS-PAGE, which indicated its native conformation as a dimer formed by two identical subunits of 16540 Da. The lectin is a glycoprotein with a low degree of glycosylation, containing galactose, xylose, glucose and mannose as neutral monosaccharides, in addition to glucosamine, which could indicate both N- and O-linkages. Amino acid analysis showed the predominance of nonpolar residues such as phenylalanine. Agglutination of human erythrocytes required divalent cations, which is affected by addition of EDTA. The lectin was more stable at 30 °C or less for at least 1 h and between pH 5.0 and 7.0. Among the various compounds tested for hemagglutination inhibition, N-acetylgalactosamine was the most active. The potential role of this lectin in recognition of the compatible cyanobacterial photobiont is discussed.


In the mid-1780's a mature Etienne-Louis Boullée (1728-1799) was commissioned to redesign the royal library of the French monarchy. His proposal was expressed through twenty-six architectural drawings, but the scheme was never built. These drawings were among the last that the French architect produced. Shortly after his death Boullée fell into obscurity and remained largely unknown well into the twentieth century. He was resurrected by historians Emil Kaufmann, Helen Rosenau and Jean-Marie Pérouse de Montclos. Their publications feature only modest written synopses of the redesign of the Bibliothèque du Roi. Scholarship has since canonized these synopses. Today's historians generally agree that Boullée produced three unique elevation drawings depicting the library's primary facade and new entrance. Each drawing is recognized as a distinct yet equally feasible alternative. In this thesis I propose that only two of the three elevation drawings correspond to the library's primary facade. I assert that the third elevation drawing—the one depicting twin figures of Atlas—was intended to be situated opposite the library's new entrance and conceived to frame an urban place and house a public fountain. This thesis demonstrates that in our haste to allegorize Boullée's unbuilt redesign of the Bibliothèque du Roi we failed to adequately interrogate the architectural drawings he produced. In this thesis I unearth drawn and built architectural artifacts evidencing Boullée's forgotten fountain. My method of inquiry hypothesizes that the same discursive tools can be used to both produce and critically interrogate orthographic drawings. The practice of search in this thesis yields discovery, not through the investigation of an historical work of architecture as it relates to history, but rather through the investigation of a set of drawings as they relate to design. Thesis Supervisor: Mark Goulthorpe Title: Associate Professor of Design NOTE: This thesis was written, designed, printed and fabricated in room 7-403 at MIT. The resulting document is intended to produce a very specific reading experience incorporating both textual and graphic forms of literacy. It is intended to be printed and viewed on 11" x 12" Mohawk Loop Inxwell Vellum Eco White 80lb Text paper bound with a black plastic spiral coil. Regrettably, the digital version of this thesis lacks much of the content found in the phsyical version. Any inquiries related to missing content or the acquisition of a phsyical copy should be directed to the author. The digital version of this thesis is best viewed in a facing page format. Boullée's Forgotten Fountain The Redesign of the Bibliothèque du Roi, 1785 All of the work in this thesis except those portions covered by footnotes is the original work of the author. Special thanks are due my thesis supervisor, Mark Goulthorpe and my readers, Mark Jarzombek and Edward A. Eigen. I am grateful to the communities at MIT's School of Architecture and Planning, Harvard University's Graduate School of Design and The Cooper Union. The first part of this thesis is a development of the paper I wrote for David Gissen's Fragment course he taught at MIT in fall 2015. The second part of this thesis is a development of the paper I wrote for Kristel Smentek's Enlightenments course she taught at MIT in spring 2016. The Louis C. Rosenburg Travel Fellowship funded my archival research at the Bibliothèque Nationale de France in addition to fieldwork and site documentation. Diego Gonzalez, a classmate at The Cooper Union, helped stimulate much of the thinking that led to this thesis. Nicholas A. Pacula MIT, Cambridge May 2017 9


The increase of language-minority children in the public schools of northeast Texas has impacted school districts which have traditionally served the educational needs of only the English-speaking. Although Texas law does provide for bilingual and other special language programs, these statutes alone will not ensure the success of such programs. Success will ultimately be determined by the community's perception of the worth of bilingual education as implemented in each local school district. With this in mind, Anglo, Black, Hispanic, and Vietnamese parents with children enrolled in selected school districts in northeast Texas responded to a questionnaire to determine their perceptions, attitudes, and knowledge about bilingual education. The statistical analysis of the parental responses revealed differences according to ethnicity, where information about bilingual education was obtained, and whether or not the parents had a child enrolled in a bilingual program.


Unit 4 [知识要点]1.First of all,Marcia told Ben she was having a surprise party for Lana,… first of all与at first的用法区别: first of all意为"首先",含有一种"强调"的意味。例如:


Recent measurements of laboratory-generated noise by breaking waves exhibit an increase in sound-pressure levels for salt water compared to fresh water over a broader range of frequencies [A. R. Kolaini, J. Acoust. Soc. Am. 103, 300–308 (1998)]. The surprise increase in sound-pressure levels inspired the study of the effects of salt on the sound radiation by single bubbles released from various size needles. A needle assembly and a false tank (2×2×4 ft), with acoustically transparent walls placed in the middle of an anechoic tank (12×12×8 ft), were used to study the acoustical characteristics of bubbles released from needles. The false tank was filled with water that contained various percentages of sodium chloride (NaCl). In this paper, the results of experiments to examine the variations in radiated sound pressure and the change in the damping coefficient of bubbles as the salinity level increased are reported. The effects of a surfactant agent such as Triton™ 100-X and other mineral acids such as HCl o...


Activation of the aci-form of nitromethane using Lewis acids for the attack of carbon nucleophiles was studied. 1,3-Dicarbonyl compounds in the presence of catalytic amounts of AuCl(3) or Cu(OTf)(2) in nitromethane solvent could be converted into methylene-bridged bis-1,3-dicarbonyl compounds.


The purpose of this research is to explore the influence of optimism on the problem-focused coping of students at Ar-Raniry State Islamic University and to find out the difference in optimism and problem-focused coping between male and female students. Data were collected from 320 students (81 male and 239 female) using a proportional stratified sampling. Data were collected by using two questionnaires, (1) Optimism by using the scale of optimism (Seligman, 2008) and (2) Problem-focused coping by using the Coping scale (Lazarus, 1984). Data were analyzed descriptively, and statistical analysis (hypothesis testing) was done using a simple regression procedure under SPSS/PC Ver.23.00. This study's results indicated a significant positive correlation between optimism and problem-focused coping among students. The respective R-square is 0.166, a result of the coefficient is 0.407. There are no significant differences in problem-focused coping and optimism among students. However, there are significant gender differences, male students are more problem-focused with coping and optimism than female students. Penelitian ini bertujuan untuk mengetahui pengaruh optimisme terhadap problem focused coping mahasiswa Universitas Islam Negeri Ar-Raniry Banda Aceh dan mengtahui perbedaan optimisme dan problem focused coping diantara mahasiswa laki-laki dan perempuan.  Sampel penelitian ini berjumlah 320 mahasiswa (81 laki-laki dan 239 perempuan) dengan menggunakan proporsional stratified sampling. Pengumpulan data dilakukan dengan menggunakan dua kuesioner, (1) Optimisme dengan menggunakan skala optimisme (Seligman, 2008) dan (2) Problem focused coping dengan menggunakan skala Coping Data dianalisis secara deskriptif dan analisis statistik (pengujian hipotesis) dilakukan dengan prosedur simple Regression. Hasil penelitian ini menunjukkan bahwa terdapat hubungan positif yang signifikan antara optimisme dengan problem focused coping pada siswa. R-square adalah 0,166, hasil koefisien adalah 0,407. Tidak ada perbedaan yang signifikan dari problem focused coping di kalangan mahasiswa, tetapi ada perbedaan yang signifikan dari jenis kelamin, bahwa laki-laki lebih tinggi problem focused coping dan sikap optimisme daripada mahasiswa perempuan.


Most conventional batteries today employ organic liquid electrolytes (LEs) that are not only flammable, but also serve as a medium for irreversible side reactions at the electrode interfaces, especially when metal is used as electrode. In post-lithium systems, such as potassium batteries, this issue is even more pronounced due to a higher reactivity of the metal as compared to lithium, and typically results in electrochemical instability leading to a rapid capacity fade of the battery.[1] When switching from LEs to solid polymer electrolytes (SPEs) that typically show better electrochemical stability at low (< 0.5 V vs. K+/K) and high (> 4 V vs. K+/K) potentials due to polymers inherent inertness, enhanced cycle life of the battery is expected.[2] Moreover, well-known disadvantage of SPEs in Li-based batteries, i.e., poor ionic conductivity at ambient temperature, could be overcome in systems with larger cation size, e.g. K+
 [3,4], potentially removing some of the bottlenecks previously encountered in the case of Li-transport.
 In this presentation, a series of poly(ethylene oxide) - potassium bis(trifluoromethane sulfonyl)imide (PEO-KTFSI) compositions with different salt concentration was investigated for their potential application as SPEs in potassium metal batteries. To identify the most promising candidate in terms of ion transport and mechanical integrity, the effect of KTFSI concentration on thermal, rheological and electrochemical properties was studied. Several electrolyte compositions were examined in solid-state potassium batteries with a potassium metal negative electrode, and a positive electrode from Prussian blue analogue family. Our results reveal the advantages of solid-state systems with respect to improved capacity retention and Coulombic efficiency as compared to the reference system with carbonate-based LE, as demonstrated in Figure 1, thus paving the way for a new generation of potassium batteries with significantly improved key performance parameters.

 Figure 1. Comparison of potassium half-cells employing different electrolyte systems: carbonate-based liquid electrolyte (LE) vs. PEO-based solid polymer electrolyte (SPE) (a) capacity retention and (b) corresponding Coulombic efficiencies.
 [1] H. Wang, D. Zhai, F. Kang, Energy Environ.
 Sci.
 2020, 13, 4583–4608.
 [2] J. Mindemark, M. J. Lacey, T. Bowden, D. Brandell, Prog. Polym. Sci.
 2018, 81, 114–143.
 [3] M. Perrier, S. Besner, C. Paquette, A. Vallée, S. Lascaud, J. Prud'homme, Electrochim. Acta
 1995, 40, 2123–2129.
 [4] U. Oteo, M. Martinez-Ibañez, I. Aldalur, E. Sanchez-Diez, J. Carrasco, M. Armand, H. Zhang, ChemElectroChem
 2019, 6, 1019–1022.

 Figure 1


Small firms are increasingly exposed to external shocks, like pandemics, inflation surge, global and local conflicts, natural disasters. A common issue is how to address these shocks and how to enable the organization to survive and continue doing business. This study explores responses to crises in some firms along a particularly challenging period, how they responded to external shocks and finds out which factors help in building their resilience.


For instance, if you are to start with making your thesis, the thesis itself is not the stimulus, rather it's the deadline, the depth of the subject, the extent of research to be done, and even your partners in your research group are just some of the many potential stimuli that can influence your response. The way you respond to these stimuli is exactly what stress is. Stress is the mismatch between the perceived obstacle and the perceived resources [3] for coping [4] with the "demands" of the obstacle.


Contemporary Christian music appeared in Hungary in the 1960s. In a unique period of Hungary when religion was suppressed and rock and roll was denounced, the merging of the two, Christian rock music was even more disapproved during the communist regime. For many, contemporary Christian music was more than simply music; it indicated opposition against the political system. Therefore contemporary Christian music was an alternative music not only from a clerical but also from a political point of view. This article tries to analyze the function of contemporary Christian music in listeners' religious folklife, their experience during listening to contemporary Christian music.1


Vacuum circuit breaker becomes more and more complicated, integrated, high-speed and intellectualized. To insure vacuum circuit breaker in its good conditions, the function of fault diagnosis gets more important than before in the process of repairing. This paper is addressed a model-based fault detection methodology for vacuum circuit breaker. At first, the dynamic model of vacuum circuit breaker is built. Secondly, DTW algorithm is introduced to compute the similarity value between the test data and the theoretical data. At last, the value comparison between the similarity and the threshold concludes whether a fault has occurred or the vacuum circuit breaker has potential hazardous effects. The experimental results show that this method is effective.


Within the electronics industry, photolithography is the primary technique by which patterns are transferred from mask to substrate. The substrates are either semiconductor wafers or printed circuit boards, both of which are nominally flat. The growth of micro-electro-mechanical and micro-electro-opto-mechanical systems (MEMS, MOEMS) and the search for higher-density electronics packaging solutions is leading to the requirement to pattern fine features onto grossly non-planar substrates. Standard photolithographic techniques cannot be used with these surfaces because the unavoidably large gap between mask and substrate allows diffractive line broadening, with a consequent loss of resolution. In this paper, we outline a method for realising photolithography on grossly non-planar substrates by using computer-generated holographic (CGH) masks. The technique that we describe enables photolithography to be realised in three dimensions, leading to the potential for a wide range of novel microelectronics packaging schemes to be realised


The free zones Certification tuberculosis and brucellosis project in the area of influence of the El Quimbo project is aimed at small and medium livestock producers in the area of influence of the Quimbo Hydroelectric . Which is carried out through interagency support among businesses ENGESA , CORPOAGROCENTRO and ICA .
The proposed goals for this project are to improve and protect the public health of consumers for this reason the objectives of this project are:

- Improve health conditions of small and medium livestock.
- Improve the hygienic - sanitary milk and meat.
- To benefit the public health center in each municipality of the department.
- Improve the income from selling milk and meat free of tuberculosis and brucellosis.
- Prevention of abortion in cows due to brucellosis.
- Prevent the spread of these diseases to farm workers .
- Improve the productive and reproductive index herd of small and medium producers.
Keep in mind that the property owner will pay only part of the cost per sample will be between $ 8000 to $ 10,000 pesos each.
The development CERTIFICATION OF TUBERCULOSIS AND FREE ZONES BRUCELOSIS project INFLUENCE IN THE AREA OF THE PROJECT Quimbo , consisting of:
1. Performing in livestock in the area of influence.
Two . Taking blood samples for laboratory analysis
Three . Certification of farms as free of tuberculosis and brucellosis
The activities conducted student are of great importance since these depend largely on the success of the project, which correspond to the livestock census and were conducted during the period of directed professional experience or internship. The student visited the premises of the municipality of The Pleasing in order to achieve the goals set by CORPOAGROCENTRO for project completion.
Scheduled activities on CORPOAGROCENTRO were performed in full and that was taken into account a number of aspects, such as field visits, will interact with farmers and staff working in different farms , exchanging knowledge both technical and traditional we've collected day after day in the farms visited
With field work as interns we are strengthening the knowledge we gained in the classroom, and because of this we are moving from the theoretical to the practical with excellent results for our professional lives.
The owners of the farms visited were found always in readiness to receive us for that reason the dissemination of this project was provided for that reason proposed by CORPOAGROCENTRO goals were achieved.
During the time of realization of targeted professional experience has resulted in a total of 377 visited farmers and counted by paths in the town of El Liking , whom they took the data requested by CORPOAGROCENTRO and socialization of the project was made and awareness related to zoonotic disease brucellosis and tuberculosis


Purpose – The aim of the study is to identify the antecedents of the Indonesian Muslim customers' intention to use Islamic mobile payments. Methodology – The data were collected from 437 respondents, i.e., 216 potential users and 221 actual users of Islamic mobile payments. The data were analyzed using a partial least squares structural equation model (PLS-SEM). Findings – The study shows that performance expectancy, perceived religiosity obligation, compatibility, and perceived trust had positive effects on the behavioral intention of Muslim customers. For multi-group analysis, perceived religiosity obligation and compatibility have a significant effect on actual and potential users. Perceived trust significantly influences actual users' behavioral intentions, whereas social influence only significantly affects potential users. Originality – The study was conducted on Islamic mobile payment using actual users and potential users as respondents. The study will contribute to the development of theories on the adoption of technology and Muslim consumers.


Material processing with laser radiation has a long tradition at Bosch. As early as in 1976, the first laser process was established in serial production. The application at that time was trimming of resistors on ceramic multi-layers. A few years later, in 1981, laser welding started with a first application. Today, it is the most popular welding technology at Bosch with more than 500 laser systems installed. In 1985, laser marking was established for the first time and has found its way into almost every production line today. In the field of laser micro processing, the next step was the introduction of laser soldering in mass production in 1992 (Fig.1). However, the number of installed laser systems is by far lower than in laser marking or welding.


In today's world, malware has grown so much. In 2020, there are more than 129 millions of Android users around the world. With Android applications dominating the devices, we hope to produce a detection tool that is accessible to the general public. We present a structure that analyze apps in the form of control flow graph. With that, we build a common graph to capture how close the apps are to each other and classify whether they are malicious or not. We compare our work with other methods and show that using control flow graph is a good choice as a representation of Android applications (APKs) and can outperform other models. We built features using Metapath2Vec and Doc2Vec, and trained Random Forest, 1-Nearest Neighbors, and 3-Nearest Neighbors Models.


This was one of the challenges discussed in a recent workshop on Prevention of Mother to Child Transmission (PMTCT) held at Entebbe Botanical Beach Hotel from November 12-15. Policy makers and health care providers from the districts of Kampala Mukono Mpigi Wakiso and Mubende participated in the three-day workshop organised by Mulago hospital based on Makerere University John Hopkins Research collaboration (MU-JHU). In the first year of life breastfeeding has been proved to be the best for babies. Prof. Francis Miiro of the Mulago PMTCT programme told participants that breastfeeding is the normal infant feeding practice in Uganda as elsewhere. However it is possible for a breastfeeding HIV positive mother to pass on the various to the baby through the breast milk. "Breastfeeding contains appropriate nutrients for the infant in a well balanced and suitable form. It is ideal but in the face of HIV we have to give mothers the information on the infant feeding options so that they make an informed choice" Prof. Miiro said. "If an HIV positive mother chooses to breastfeed her baby she should be supported to exclusively breastfeed for a period not exceeding six months preferably three. This is because the risks of transmission increase with a prolonged breastfeeding period" said Dr. Philippa Musoke of MU-JHU research collaboration. But even then mothers should be advised on how to do it safely. The ministry highly recommends exclusive breastfeeding - giving only breast milk to the baby especially for HIV positive mothers. This is especially for those who are not able to use replacement feeding. But the ministry acknowledges this is not an easy option. (excerpt)


I begin my comment on Gregory Crespi's essay (1997) by thanking him for the thoroughness of his review of Robin Paul Malloy and Christopher K. Braun's collection Law and Economics: New and Critical Perspectives (1995) but especially for the clarity with which he reviewed my chapter (Ulen 1995). He has treated very gently and generously my attempt to show the implications for tort law of the expanding literature on cognitive limitations. Indeed, he has done such a careful job in his review that I can be mercifully brief.


Intermodal (IM) freight transport systems and their components play a significant role in world economies. Maritime transport operating within an IM system involving land-water interfaces remains the dominant mode for international trade. Ports and other terminals are critical components of these systems. Many of these components, as well as supporting rail and roadway system infrastructures, however, are by the nature of their designs and locations inherently vulnerable to rising sea levels, significant precipitation events, storm surges and consequent coastal flooding. Caldwell et al. (2002) describe potential impacts on freight transport due to climate change. The costs of such impacts can be excessive. For example, direct and indirect costs due to weakened infrastructure at ports and the like resulting from increased storm intensity and higher sea levels can lead to losses in the billions of dollars per day (Haveman and Shatz, 2006).


Participatory Design Process has recently been more and more important in the light of effective design and residents' acceptance. The purpose of this study is to examine the post-occupancy evaluation of residents to an irrigation channel repaired by the agreement in participatory workshops for a project to repair attractively the channel and the area along it, in an urban-fringe settlement in Kamo-cho, Kyoto Prefecture. The questionaire survey and analysis show that the general residents' evaluation to the channel is commonly favorable beyond the demographic attribution, and the workshop participants' evaluation is more favorable than the other residents one.


In this paper I am going to give a mathematical theory of Integrated Information Theory, using entropy as measure of information and hence, as the information distance function. Also, we will consider a set, whose open subsets are mechanisms and topology is the system, we use these two modification in the structure of Integrated Information Theory [2] and Quantum Integrated Information theory [3], to define Entropic Integrated Information Theory, we will also justify our claims to use why entropy should be use as a measure of cause/effect information and as information distance function using [1]. We will also see the relationship of entanglement with concept and conceptual information. This paper is an attempt to binds consciousness, quantum information, entanglement and quantum mechanics together.


The spanwise aerodynamic loads of the wind turbine blade are investigated numerically. The blade shape such as twist and chord length along the blade span is obtained from the procedure of aerodynamically optimal design. The rated tip speed ratio and the rated wind velocity are set to 7 and 12m/s respectively. The BEM method is applied to obtain both the aerodynamic performance of the wind turbine (Fig.1) and the spanwise aerodynamic loads along the blade span including Prandtl's tip loss factor. The maximum running power coefficient is occurred around 90% radial position from hub (Fig.2). The distributed aerodynamic loads along the blade span can be used for structure analysis.


Latex waste products contain rubber hydrocarbon of very high quality, which is only lightly cross linked. Selected wastes such as thread waste and glove waste were modified into processable materials by a novel economic process and thermoplastic elastomers were prepared by blending these modified waste materials with high density polyethylene in various proportions. The mechanical properties as well as the rheological behaviour of these blends were evaluated and compared with those of the natural rubber-high density polyethylene blends.


The aim of the study was to describe a clinical case of noninsulinoma pancreatogenous hypoglycemia (NIPH).Materials and methods. Patient R. 42 years old, woman, was admitted with complaints on spastic abdominal pain, heartburn, flatulence, bloating. The patient had a history of cramping pains in the upper abdomen, episodes of hypoglycemia up to once a day, periodically diarrhea with undigested food up to 3 times a day, and frequent weakness during last 9 years. In 2013, she was diagnosed with a neuroendocrine tumor of the pancreas, and therefore distal pancreatectomy was performed that year. According to histological and immuno-histochemical studies, foci of islet-cell hyperplasia (nesidioblastosis) were noted in the tail of the pancreas against the background of tissue fibrosis. Non-insulinoma pancreatogenous hypoglycemia of adults (NIPH) was diagnosed, enzyme replacement therapy and Octreotide-depo were prescribed. Relapses were noted twice. Two weeks before admission, the patient noted episodes of hypoglycemia. Upon admission, the patient had state of moderate severity, irregular stools up to 3–4 times a day. Antibacterial treatment was carried out, enzyme replacement therapy, octreotide was continued.Results. On the 7th day of hospitalization, the patient was stabilized: the level of glycemia was 4.5–4.9 mmol / l, the frequency and consistency of stool normalized. No data for decompensation of the disease has been received. The patient was discharged in a satisfactory condition.Conclusion. This clinical case demonstrates the influence of NIPH on the patient's quality of life and the need for constant vigilance against the recurrence of hypoglycemic episodes, despite the treatment. This case can improve the awareness about this rare but important disease.


The invention discloses a method for judging whether a three-phase alternating-current generator winding is lack of a parallel branch. According to the method, the qualified three-phase alternating-current generator winding is tested, a line resistance and a phase resistance are calculated when the specified temperature is obtained, and then a line resistance and a phase resistance in the case of lack of the parallel branch are calculated, thus the line resistance and a deviation amplitude in the case of lack of the parallel branch are calculated, and taken as a standard for other three-phase alternating-current generators to be tested. The method is capable of conveniently and rapidly judging whether the three-phase alternating-current generator winding is qualified, thus effectively preventing generators lack of parallel branches from being submitted as normal products.


An ecto-ATPase activity was demonstrated for the first time at the outer surface of bovine lens epithelial cells. The enzyme needs Mg2+ or Ca2+. It is clearly discernible from th


The following topics are discussed: site selection and analysis, preliminary site planning, general design approaches and techniques for solar access, specific design strategies to protect solar access, trees and landscaping, two examples of solar site planning, and private agreements to protect solar access: covenants and easements. Included in appendices are: a glossary, skyspace angles, shadow length tables and equation, determining density, and references. (MHR)


To assess the continuity of radical attitudes and values, a 12-year follow-up study was conducted of groups of former left-wing student activists and nonactivists. Questionnaires containing measures of attitudes and values were obtained by mail from 73 former activists and 86 nonactivists. Results indicated that 12 years later (1982), activists held more radical political and social attitudes than nonactivists and had maintained a distinctive value system. Former activists also showed little erosion of their radical attitudes or value systems


Abstract In his Apology, Sidney makes what appears to many readers to be an adroit synthesis of humanist defenses of poetry, joining Neoplatonic idealism to claims of ethical utility and delivering this synthesis with the winning playfulness of a shrewd rhetorician. A closer look at his argument, however, reveals it to be a complex and self-conscious fiction, which gestures toward external values only to turn back on its own assumptions. The playful tone shows that Sidney is fascinated by the conceptual difficulties that confront him but that he is incapable of resolving them. Sidney's intellectual performance in the Apology demonstrates his affinities with Renaissance thinkers like Nicholas of Cusa, who imagined all mental activity to be a ceaseless fabrication of conjecture and metaphor.


Some recent advances in study on wheel/rail dynamic safety and train derailment of railway during an earthquake are reviewed in this paper.Firstly,the interaction models between wheel and rail are discussed,including the closed contact model between wheel and rail,the simplified elastic contact model,and the elastic contact model.The description and the input method of the earthquake are then reviewed.Under the action of the earthquake,the criteria of derailment of the train,the early warning systems and the anti-derailment measures are also discussed.In addition,in the research of the derailment during an earthquake,the applications of the theory of the wheel-rail coupled dynamics are analyzed,and the geometrical parameters of dynamic contact and their boundary conditions are discussed when a vehicle derails at high speed.Lastly,the promising future development in this area is discussed.


A novel terahertz modulator based on graphene is proposed and designed. The device consists of a silicon ridge covered by a graphene sheet. The transmission properties of the proposed structure demonstrate that the introduction of graphene can improve the switching and filtering performance of modulators, and enhance its field confinement capability. In the case of the number of layers, a blue shift can be observed in the center wavelength with increase of graphene layers. Meanwhile, the relationship between the number of layers and the peak of reflection spectra is an inverse proportion function. In addition, we find that the center wavelength is almost unchanged with respect to the different chemical potential, thus the effective refractive indices of the cross section of light propagation direction can be well preserved. These findings will contribute to the research and development of graphene based THz waveguide modulators.


Regional accreditation is an important and viable way for institutions to regulate themselves through standards development and their attainment as examined through peer review. Cycles of accreditation are useful in comparing and contrasting overall institutional effectiveness over time and against mutually agreed upon parameters. In the past 15 years, regional accrediting agencies have placed an increased emphasis on student outcomes as one of many measures of how well the institution is fulfilling its mission. This paper examines the status of outcomes assessments in the accreditation processes of the regional accrediting associations. The following questions were posed and answered as a result of this research: – What do research studies tell us about the use of outcomes assessment in the accreditation process? – What are the areas of agreement among regional accrediting agencies on outcomes assessments? – What resources do regional accrediting agencies use to support outcomes assessments in the accreditation process? – What areas could benefit more from an analysis of outcomes assessments but are currently somewhat limited? Research studies tell us that the goal of using outcomes assessments to determine the institution's mission and goal fulfillment is still evolving for most institutions. The goal of capacity building as a result of outcomes assessments is far off. More planned intermittent research is needed at all levels of the academy, community colleges, 4 year institutions, and universities to differentiate the components of assessments that are useful at each level. Questions posed as a result of outcomes assessment in the accreditation process include those related to budget development and expenditures, academic program viability, and student focused institutional planning and development. Areas that could benefit more from an analysis of outcomes assessments but are currently somewhat limited include student affairs data analysis including surveys on student participation in tutoring and campus activities, work study program participation, and outcomes assessments findings from federally funded student affairs programs. There is little evidence in the literature that outcomes assessments are being used to improve the curriculum, or change curricular direction to make it more in line with institutional mission. There is evidence that policy issues in accreditation are greatly affected by federal legislation.


The paper examines the status of anaemia and body mass index (BMI) among fisherwomen of Karang Island Village, Manipur, India. Altogether 180 Meitei fisherwomen of age group 15 to 49 years were chosen for the study. Two anthropometric measurements viz., stature and body weight were taken on each subject. For estimation of haemoglobin level two standard methods namely, haemoglobin colour scale (HCS) and Sahli's haemoglobinometer were employed. About 70% of the fisherwomen of Karang village are in normal BMI category, while 16 % of them are underweight, 11 % overweight and 3 % obese. The prevalence of anaemia is notably high among the fisherwomen of this village with a frequency of 68.89%. Women with normal BMI and non-anaemic constitute 24.44%. The mean values of haemoglobin concentration measured by HCS and Sahli's method is 10.82gm/dl and 10.94gm/dl respectively. The two mean values were tested for t-test of significance and found statistically insignificant (t=0.852). The two adopted methods for haemoglobin estimation viz., HCS and Sahli's method are found reliable. The correlation value of BMI and haemoglobin level shows negative in association (r = 0.060) and the value is found insignificant (t=0.566). The insignificance of this relationship means there is no correlation.


Shiver et al describe a set of fractal activities in which students can accomplish much more than just creating a fun set of cards that simply resemble an art project. The goals of these activities, designed for an algebra 1 class, are to encourage students to generate data, look for and analyze patterns, and create their own models--all from a set of fractal cards that they construct. The set of activities and extension could also be used in an algebra 2 class to review exponential equations and practice working with basic exponent rules. These fractal cards produce perfect data for developing concise, explicit equations while requiring students to think critically.


Imputation is commonly used to compensate for missing data in surveys. We consider the general case where the responses on either the variable of interest y or the auxiliary variable x or both may be missing. We use ratio imputation for y when the associated x is observed and different imputations when x is not observed. We obtain design‐consistent linearization and jackknife variance estimators under uniform response. We also report the results of a simulation study on the efficiencies of imputed estimators, and relative biases and efficiencies of associated variance estimators.


Objective To evaluate the anesthetic effect of propofol combined with ketamine during squint correction surgery in children.Methods Forty children scheduled for squint correction surgery were randomly divided into the propofol group (group P,n=20) and the ketamine group (group K,n=20).Anesthesia of both groups was induced with the same medication,but maintained with propofol combined with ketamine in group P and ketamine only in group K.Systolic blood pressure(SBP),heart rate(HR),respiratory rate(RR) and SpO 2 were determined at different stages.Wake-up time,the frequencies of sputum suction,and the postop incidence of restlessness and nausea and vomiting were recorded and compared in both groups.Results There were no significant differences between two groups in RR and SpO 2(P0.05).SBP and HR in group P were significantly lower than those of group k during operation(P0.05).There were also significant differences in wake-up time,the frequencies of sputum suction,the postop incidence of restlessness and nausea and vomiting between both groups(P0.05).Conclusions Intravenous anesthesia of propofol combined with ketamine can antagonize circulatory excitation caused by ketamine and decrease secretion of airway.It's also found that children wake up quickly and lower incidence of restlessness and nauses and vomiting.Intravenous anesthesia of propofol combined with ketamine is a safe and effective anesthetic technique for squint correction surgery in children.


An active phased-array transceiver system design for V-band applications is given for the requirements related to millimeter-wave communication applications, and the key structures are simulated. The test results show that the system beam scan range is ± 50°, EIRP reaches 40 dBm, and the spurious rejection is above 40 dB, which meets the requirements of the index, and also verifies the feasibility of the design.


Religion and the State: The Making and Testing of an American Tradition. By EVARTS B. GR•.EN•.. New York: New York University Press. 1941. Pp. viii, 172. ($2.75) Tam is a useful survey of a subject which is more complicated than is often thought. Beginning with an outline of Old World theories of Church and State, prior to the American settlements, Professor Greene traces the development of American doctrine and practice respecting this question down to the "monkey trial" and the recent refusal of citizenship to those who declined, through religious scruples, to swear to "defend" the Constitution of the United States. He makes it clear that the problem of Church and State in America was not, as is so generally supposed, solved at a single blow--if, indeed, it has ever been conclusively solved at all. In a valuable chapter on the Revolutionary settlement he points out that separation of Church and State was not achieved instantaneously or universally at that time, but was left to the disposition of the various states; and that in the case of Massachusetts the process was not complete until 1833. Even then, religion remained as a source of many legal and political complications throughout the nineteenth century and down to our own times; and the problem has been, and is, particularly troublesome in the field of education. Mr. Greene also makes the important observation that the separation of Church and State in America "has not prevented recognition by state and federal governments of religion per se as a desirable part of the social order" (p. 96). Apart from exposing the complexity of Church-State relationships in America, this work is principally valuable as a handbook. Very compactly, Mr. Greene has covered a vast range of material, and touched on every salient feature of his theme; but it was of course impossible in so slim a volume to deal thoroughly or profoundly with any phase of the subject. Moreover, even so objective a summary was bound to be in a sense one-sided. Despite the inclusion of statements of Church doctrine, it is really the State theory of the Church which occupies the author, and Church theory of the State is treated only as a factor in the political problem. One should therefore not look in this volume for much light on the internal nature of various Christian political theories, or on the problems which have confronted the Churches, as distinct from the State, in the process of adjustment to modern political conditions. It is of course a significant fact in itself that from the eighteenth century the balance of interest in this whole question has shifted from the side of theology to that of secular politics. Good bibliographical notes are appended. N. F. LANGFORD


Objective To compare the surgical results of different configurations of reverse superficial radial nerve neurocutaneous flap on dorsoulnar aspect of the thumb in repairing soft tissue defects of the thumb.Methods A total of 31 cases of soft tissue defects of the thumb were treated with reverse superficial radial nerve neurocutaneous flap on dorsoulnar aspect of the thumb.In 11 cases (group A) only a narrow fascia pedicle was retained without including a substantial dorsal vein in the flap.In 20 cases (group B) a wider fascia pedicle was designed to include a continuous,thick dorsal vein.Results Postoperative venous congestion occurred in 3 cases of group A causing the flaps to turn purple.The congestion subsided in 3 to 4 days.Partial skin necrosis was found in one of these cases.No venous congestion was noted in group B.All the flaps survived uneventfully.Conclusion Including a continuous,thick dorsal vein within the fascia pedicle can significantly reduce postoperative venous congestion and improve flap survival.

Key words:
Surgical flaps;  Thumb;  Superficial branch of the radial nerve nutrient vessels;  Soft tissue defects


The Atlantic meridional overturning circulation (AMOC) is an important component of the climate system. Models indicate that the AMOC can be perturbed by freshwater forcing in the North Atlantic. Using an ocean‐atmosphere general circulation model, we investigate the dependence of such a perturbation of the AMOC, and the consequent climate change, on the region of freshwater forcing. A wide range of changes in AMOC strength is found after 100 years of freshwater forcing. The largest changes in AMOC strength occur when the regions of deepwater formation in the model are forced directly, although reductions in deepwater formation in one area may be compensated by enhanced formation elsewhere. North Atlantic average surface air temperatures correlate linearly with the AMOC decline, but warming may occur in localised regions, notably over Greenland and where deepwater formation is enhanced. This brings into question the representativeness of temperature changes inferred from Greenland ice‐core records.


Several mediator models have been developed which share some basic assumptions about the antecedents and consequences of effective leadership behavior. Individual characteristics of the leader pred...


Reduced graphene oxide (RGO) nanosheets with high quality were chemically synthesized by hydrothermal reduction of a well-dispersed graphene oxide (GO) suspension. The electrochemical behavior of guaiacol was studied on different carbon material surfaces. Compared with the bare glassy carbon, graphite, and GO, RGO nanosheets exhibited a strong enhancement effect and the electrochemical oxidation response of guaiacol was remarkably improved. The influences of the pH value, amount of RGO, scan rate and accumulation time on the oxidation signal of guaiacol were investigated. Based on the enhancement effect of RGO, a simple, fast and sensitive electrochemical method was developed for the detection of guaiacol. The linear range was from 0.5 μM to 500 μM with a correlation coefficient of 0.998, and the limit of detection was as low as 0.2 μM (S/N = 3). Finally, it was used to determine guaiacol in bamboo juice samples, and the recovery was over the range between 98.9% and 105.8%.


Multivibrators based on operational transconductance amplifiers (OTA) are considered. The first is an astable bridge multivibrator with one OTA. This circuit is useful for two-wire bridge-to-frequency converters. The second circuit is an astable multivibrator with two OTAs. This circuit provides a linear dependence of the oscillation frequency on the sensor control current. Both circuits are nonsaturated multivibrators. Calculation of their oscillation frequency involves a linear model which describes the circuit behavior near the transition point from one quasistable state to another. The circuits with bipolar and MOS OTAs are treated.<<ETX>>


In recent years a type of Conversational User Interface (CUI) called chatbots has been more common, these are integrated and used on various platforms such as Slack, Facebook and Skype. Chatbots ar ...


The spectral parameters of neodymium ions in anisotropic YLiF4, SrMoO4, PbMoO4, CaMoO4, SrWO4, and BaWO4 crystals with a scheelite structure are experimentally studied in the region of 1 μm. The luminescence spectra of neodymium ions at the 4F3/2 → 4I11/2 transition in these crystals exhibit pronounced polarisation dependences. It is shown that, using different orientations of the active laser element and separating a particular radiation polarisation, one can control the spectral dependence of the active medium gain, switch the laser wavelength, and create dual-wavelength lasers. A dual-wavelength Nd3+ : YLiF4 laser emitting at λ = 1047 and 1053 nm with identical linear polarisations and good temporal and spatial matching is demonstrated.


Oral Manifestations: Angular stomatitis is common in the infectious infantile stage of the disease and may cause permanent scarr-ing of the lips (rhagades). High arching and late gummatous perforation of the hard palate result from bone infection, while typical changes occur in the permanent dentition. The upper central incisors are stunted and peg-shaped, being narrowest at the incisal margin which is notched (Hutchinson's teeth) (Fig. 1). The first molars sometimes have maldeveloped cusps and a mulberry-like surface (Moon's molars) (Fig. 2).


Published online in Wiley Online Library (wileyonlinelibrary.com) DOI 10.1002/bio.2341 ISBC 2012 17th International Symposium on Bioluminescence and Chemiluminescence 9 Preliminary attempt for pharmacometrics assay by bioluminescence imaging in Drosophila embryogenesis Ryutaro Akiyoshi and Hirobumi Suzuki Research & Development Division, Olympus Corporation E-mail: firstname.lastname@example.com Drosophila has been widely used as a model animal for genetic, developmental and physiological studies due to easy crossing and breeding and short life cycle. Nowadays, it could be used for pharmacometirc assay related to human disease. Because biologically important inventions of morphogenesis have been done in Drosophila, and it is confirmed that developmental pathways in morphogenesis are conserved through evolution. For example, wingless and armadillo genes related to segment polarity forming signal system in Drosophila are homologous with Wnt and betacatenin genes in mammals, and some factors of the Wnt/betacatenin signaling pathway relate to not only morphogenesis but also cell growth, transformation and so on. Therefore, Drosophila could be an alternative model of mammals for pharmacometrics assay. In order to develop the pharmacometrics assay system of drug-induced effect during embryogenesis, we established bioluminescent transgenic Drosophila of the armadillo and applied it to whole Drosophila bioluminescence imaging. We cloned armadillo (arm) promoter region fromD.melanogaster genome and constructed a bioluminescent reporter vector of arm:: ELuc by inserting the arm promoter and click beetle luciferase gene, (Emerald Luc, Toyobo), into KP124 vector. The arm::ELuc vector was injected into fertilized eggs of D. melanogaster by microinjection method, and we established transgenic D. melanogaster strain undergoing processes of crossing with another strain. The arm gene expression pattern of this strain until hatching was observed by the bioluminescence microscope (LV200, Olympus) together with morphogenetic movements for 18 hours. The arm activity through blastula stage was observed in blastoderms slightly, and increased in whole embryo at the beginning of gastrulation, and then it suddenly decreased at the end of gastrulation. In the process of midgut formation going with germ band shortening in parallel, the arm promoter activity increased in midgut primodium dramatically and continued until hatching. On the other hand by ionomycin treatment that inhibits Wnt signal, the arm promoter activity was depressed until the end of gastrulation and increased at the timing for midgut formation. In spite of this unusual gene expression by ionomycin treatment, the embryo hatched normally. These results suggest that bioluminescence imaging of promoter assay in Drosophila embryogenesis could provide a new pharmacometrics method for evaluating not only gene expression pattern influenced by drugs but also morphological changes during the developmental process. Effect of tritium on bioluminescent systems MA Alexandrova, GA Badun and NS Kudryasheva Siberian Federal University, Svobodniy 79, 660041, Krasnoyarsk, Russia Moscow State University, Chemistry Dept., 119991, Moscow, Russia Institute of Biophysics SB RAS, Akademgorodok 50, 660036. Krasnoyarsk, Russia Luminescence 2012; 27: 95–178 Copyright © 2012 John Bacterial bioluminescence (BL) assay has been used to monitor toxicity of radionuclide solutions for the first time in (1,2); toxicity of alpha-radionuclides Am-241 and U-(235+238) was studied using bioassays based on Photobacterium phosporeum. Details of BL kinetics and role of peroxides in activation and inhibition of BL intensity in Am-241 solutions were discussed in (3). Tritium, beta-emitting nuclide, is one of the most widespread radionuclides, its content increases in environment now. Chronic effect of tritium (0.25–10 MBq/L) on growth and bioluminescence of the bacteria was studied in (4). Purpose of the current study was to compare effects of tritiated water (0.0002–100MBq/L) on different BL systems. Three BL assay systems were applied: (1) intact luminous bacteria P. phosphoreum 1883 IBSO; (2) a microbiotest 677F preparation i.e. lyophilized luminous bacteria cells of P. phosphoreum 1883 IBSO; and (3) a kit of reagents for analytical BL, which included lyophilized preparations of luciferase (0.5mg/mL) and NADH:FMN-oxidoreductase (0.15 units of activity). All assay systems were produced at the Institute of Biophysics SB RAS, Krasnoyarsk, Russia. Tritiated water (HTO, "Isotop", Russia) was used as a source of beta-radiation. HTO was added to BL solutions. Radioactivity of the solutionswas: 0.0002, 0.002, 0.02, 0.2, 2.0, 10, 20, 50, 100MBq/L. The samples were kept at +4 C, their BL intensity was measured by 'TriStar Multimode Microplate Reader LB 941' (Berthold Technologies). BL kinetic curves in the presence of HTOwere compared for three BL systems. Activation of BL of enzymatic system (3) was observed at lower radioactivity of tritium solutions (A<10MBq/L) and BL inhibition – at higher radioactivity (A>10 MBq/L). Effects of tritium on bacterial systems (1–2) were of different type: BL activation was observed at initial time of exposure to tritium (less than 50h for system (1), and 30h for system (2)), and BL inhibition at final time of exposure. The results show that the resistance of the BL function to tritium increases from enzymes to cells, i.e. with increase of complexity of the systems. It was assumed that BL activation and inhibition by tritium can be related to intensification of the processes of electron density redistribution in the course of betadecay. BL activation is discussed in terms of "radiation hormesis".


In this paper, a combined static and dynamic scheme is proposed to optimize the block placement for endurance and energy-efficiency in a hybrid SRAM and STT-RAM cache. With the proposed scheme, STT-RAM endurance is maximized while performance is maintained. We use the compiler to provide static hints to guide initial data placement, and use the hardware to correct the hints based on the run-time cache behavior. Experimental results show that the combined scheme improves the endurance by 23.9x and 5.9x compared to pure static and pure dynamic optimizations respectively. Furthermore, the system energy can be reduced by 17% compared to pure dynamic optimization through minimizing STT-RAM writes.


Abstract This article examines how South Korea has used the ASEAN Plus security platforms to hedge between the US and China and why it has not participated in the FOIP strategy. It argues that the platforms' neutral guise, owing to ASEAN centrality and their global norms-based agenda has allowed Korea to passively voice its alignment with the US, thereby answering to the pressure for a higher commitment from the US and clearing the political risk of linking the alignment decision to its own views. It asserts, therefore, that access to effective multilateral security platforms allows higher leverage to the weaker ally in an asymmetric alliance relationship.


Emulsified perfluorocarbons (PFC) can dissolve oxygen and this property makes them attractive as potential oxygen-transport fluids (Riess and Le Blanc, 1982). S ~ I E of the physiological effects of emulsified PFC have been examined in several species, including h m s (Lawe and Bollands, 1985). The mst widely tested preparation is the camnercial emulsion, Fluosol-DA 20% (F-DA; Green Cross, Japan) which contains perfluorodecalin (FDC) and perfluorotripropylamine, enulsified with Pluronic F-68 surfactant (Naito and Yokoyama, 1978). A specific problem inherent with available ccmnercial emulsions is their poor storage stability, resulting in increased particle size (Riess and Le Blanc, 1982). The major cause of droplet growth in enulsions is coalescence, but this can nomlly be retarded using emulsifying agents which form electrostatic and mechanical barriers at the oil/water interface. m e r , a more subtle means of instability can occur by a process of mlecular diffusion knm as Ostwald Ripening (Davis et al, 1981) and this can occur even if particles have excellent barriers to coalescence. We report here scme of the physicochemical properties of navel formulations of PFC emlsions stabilised against Ostwald Ripening.


Topics this issue- Mathematics: geometric vs. arithmetic progressions; logarithms; antilogarithms; orders of magnitude; exponential function. Geology: Richter magnitude; density; viscosity; Mohs hardness; Knoop hardness; solar system; geologic time scale. INTRODUCTION Asimov (1982, p. 15) tells of the first university. It was named The Academy for Academus, who once owned the grounds. The founder of the Academy was Plato (~427 B.C. to ~347 B.C.). Over the entrance, Plato inscribed the words, "Let no man ignorant of geometry enter here." To Plato, mathematics (geometry) was a domain of idealized abstraction. Now, mathematics is studied by many in academia ("the academy") because of the insight it gives to the material world. To many, mathematics provides a way of conceptualizing the real world. This includes the real world of geologists. The world of geologists involves big space and big time. Geologic variables vary over a huge range. This huge variation applies not only to the basic concepts of length and duration, but also to properties of geologic substances - properties such as density, viscosity and hardness. To conceptualize points along the axes or these variables, we often must take steps that are multiplicative rather than additive. We must expand our mind to think of geometric progressions, not just arithmetic ones. The entrance to the geologic academy today could be marked with the sign "Let no person ignorant of geometric progressions enter here." LOGARITHMIC SCALES A logarithmic scale of a graph converts geometric progressions to arithmetic progressions. A geometric progression is a succession of numbers that increase (or decrease) by a common ratio; for example, 1, 2,4, 8, is an increasing geometric progression with a common ratio of 2. An arithmetic progression is a succession of numbers that increase (or decrease) by a common difference; for example 20, 18, 16, 14, is a decreasing arithmetic progression with a common difference of -2. The spreadsheet of Figure 1 illustrates how a logarithmic scale converts geometric progressions to arithmetic progressions. Column C lists three geometric progressions: Progression 1 has a common ratio of 10; Progressions 2 and 3 have common ratios of 2 and 3, respectively. The upper graph of Figure 1 has an arithmetic scale. Note how the numbers of each progression are spaced further apart as they increase. In Progression 3, for example, there is more space between the sixth and seventh numbers (32 and 64) than between the first and sixth (1 and 32). The lower graph has a geometric scale. On this graph, the numbers in each progression are spaced equally. For each one of the geometric progressions, there is a common difference in the height or the numbers on the logarithmic chart. The heights of successive numbers form an arithmetic progression for each geometric progression. For the first progression, with a common ratio of 10, the common difference on the log scale is the same as the spacing on the log axis. Call this distance 1 unit. Then the spacing between the numbers of Progression 2 on the logarithmic chart is 0.301 units, or log(2). Similarly, the spacing between the numbers of Progression 3 is 0.477 units, or log(3). RICHTER MAGNITUDE The Richter Magnitude, which quantifies the size of earthquakes, is probably the most well known logarithmic scale in geology. Spacing along the log scale - The spreadsheet of Figure 2 lists Richter magnitudes (Column C) for six selected earthquakes (Col D). The magnitudes (Ms) range from 6.5 to 8.6. The lower graph of Figure 2 is a plot of these magnitudes. The upper graph is a plot of the antilogarithm of the magnitudes (Col F). Thus the ordinate (y-axis) of the upper graph is an arithmetic scale. The ordinate of the lower graph is a logarithmic scale. In reading graphs with logarithmic scales such as the lower graph in Figure 2, one needs to remember that the numbers on the logarithmic scale represent steps along a feometric sequence. …


The role of trade unions in helping women beedi workers to obtain statutory benefits has been analysed in this paper with the help of data collected from 28 trade unions and 876 beedi workers from four Karnataka districts. It is shown that in the context of growing unorganised component within the beedi industry and limited membership base, trade unions find it difficult to organise women workers to access statutory benefits although they have fairly good understanding of the situation and needs of the workers. An important finding is that production relations emerging within the industry explain whether a worker is able to access the benefits or not. It is argued that when workers are being increasingly unorganised, the role of trade unions in ensuring that there is collective bargaining of the workers will become either marginal or non-existent as trade unions find it difficult to change the strategies in view of changing conditions.


The purpose of the present master thesis is the experimental and analytical investigation of a strengthened and energy efficiency upgraded masonry, subjected to out of plane cyclic load. The strengthening technique referred to the application of composite materials and especially Textile-Reinforced Mortar (TRM) layers, while the energy technique included insulating plates. The extensive experimental program lasted six months and was conducted at the Structural Materials Laboratory of the Civil Engineering Department at the University of Patras.
17 identical rectangular specimens of masonry were constructed and reinforced. One specimen was tested without any reinforcement, any insulation and was used as reference for the comparison with all the rest. The masonry walls were separated in two groups according to the type of their insulating plate. The first group consisted of expanded polystyrene insulation EPS and in the specimens of the second group were placed Ytong Multipor. The reason why two different types of insulation were used, is that before the out-of-plane bending, the specimens with Ytong were subjected to fire testing. The Ytong Multipor plates have an excellent fire resistance.
The goal of the investigation is the study of the ways that the composite materials and the insulation collaborate together and with the masonry, aiming to increase the strength and the ductility. For all the specimens, the number of TRM layers remained constant for each wall and only for the second group of specimens the number of plates differed. The parameters under investigation included mainly the row where the layers were applied on the wall surface, the step of controlled displacement for each loading circle, the remaining fire resistance, the quality of the insulation plates and the thickness of Ytong Multipor in order to protect the reinforced masonry. Furthermore, were realized a numerical analyses for the first group and the results of the numerical analyses were compared with the experimental data.
In this study, the experimental results indicated that TRM layers are quite effective in terms of increasing both the strength and deformation capacity of the retrofitted masonry in case of out-of-plane bending. The composite materials are capable to augment the ductility, the initial elastic stiffness, as well as the dissipating energy and to provide a structural upgrade to a masonry wall. The addition of insulation EPS offered a much better behavior in terms of strength and ductility, especially when the TRM layers are outside of the insulation. On the other side, when was used insulation Ytong, the values of strength were very low. However Ytong provided the desired protection of the reinforced masonry in case of fire, under the condition that the thickness of Ytong is sufficiently large. From the response of specimens tested, it can be concluded that the combination TRM layers and insulating plates is an extremely promising solution for the upgrade of masonry.


Acute myeloid leukemia with mutated nucleophosmin (AML NPM1 mut) represents about one-third of all adult AML and shows distinctive biological and clinical features. For this reason, AML NPM1 mut is planned to be included as a separate category in the revised WHO classification. A yet controversial issue, however, is whether AML NPM1 mut with or without multilineage dysplasia (MLD) may differ biologically and clinically, as the presence of MLD might confer a negative prognostic impact. A further feature that was suggested to be typical for NPM1 mutated AML is "cup-like" morphology of blasts. We here analyzed 128 pts with AML NPM1 mut and normal karyotype at first manifestation (59 females, 69 males; median age 60.5 years; 23.5–79.3 y). We investigated in parallel cytomorphology from bone marrow and/or peripheral blood, chromosome banding analysis, and molecular analyses. Presence of dysplasia was defined by dysplastic features in ≥50% of cells in the respective hematopoietic lineage as defined by the WHO. A 5% cut-off was taken for the presence of "cup-like" morphology of blasts. All cases were additionally analyzed for the FLT3- ITD, and in 122 pts for the FLT3- TKD. Statistical analysis was performed for overall survival (OS), and event-free survival (EFS) according to Kaplan-Meier using the 2-sided log-rank test. Cox regression analysis related OS and EFS with the analyzed parameters. We found a predominance of the FAB M1 (21.3% of all cases), M2 (33.9%), and M4 subtypes (28.3%). Cup-like morphology in ≥5% of all blasts was observed in 39 of 127 evaluable cases (31.3%) confirming previous observations of an association of the NPM1mut and this specific blast appearance. Molecular characterization detected NPM1 mutation subtype A (n=90/122; 73.8%), B (15/122; 12.3%), and D (7/122; 5.7%), which was in accordance to previous studies. In 56 cases (43.8%) there was a coincidence with an FLT3 -ITD. Dysplasia of granulopoiesis was detected in 28/126 (22.2%), of erythropoiesis in 28/104 (26.9%), and of megakaryopoiesis in 57/87 (44.5%) cases in which the respective cell lineage could be analyzed. MLD (≥2 dysplastic hematopoietic lineages) was detected in 28 of 105 evaluable cases (21.9%). Clinical follow-up was available in 104 pts. (median follow-up 12,7 months). CR rate was 83.1% in 77 evaluable pts., and median EFS was 42.1 months in 104 evaluable pts (median OS not reached). An additional FLT3 -ITD had a significantly inferior OS (p=0.003) and EFS (p=0.007), confirming the present series being representative. However, the presence of MLD was not significantly related to any endpoint such as CR rate, EFS, or OS. There was no association between MLD and the NPM1 -subtype. Also, there was no significant correlation of MLD and the presence of a FLT3 -ITD. In conclusion, the presence of MLD in AML NPM1 mut with normal karyotype had no impact on CR rate and outcome, whereas coincidence of FLT3 -ITD significantly worsened prognosis. These results give further evidence that AML with NPM1 mut AML is a unique biological entity with clinical course mainly influenced by FLT3 -ITD coincidence. These data do not support any additional prognostic influence of MLD in this AML subtype.


A numerical solution of the two-dimensional Saint Venant equations is presented for the study of the propagation of the floods through the crossroads of the city. The numerical scheme is a Runge-Kutta discontinuous Galerkin method (RKDG) with a slope limiter. The work studies the robustness and the stability of the method. The study is organized around three aspects: the prediction of the water depths, the location of the right and oblique hydraulic jumps in the crossing, and especially the distribution of the flow discharges in the downstream branches. The objective of this paper was to use the RKDG method in order to simulate supercritical flow in crossroads and to compare these simulations with experimental results and to show the advantage of this RKDG method compared to a second-order finite-volume method. A good agreement between the proposed method and the experimental data was found. The method is then able to simulate the flow patterns observed experimentally and to predict accurately the water depths, the location of the hydraulic jumps, and the discharge distribution in the downstream branches.