Address reprint requests and correspondence to Lorraine A. Fitzpatrick, MD, Endocrine Research Unit, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (e-mail: email@example.com). Estradiol levels decline intermittently during the perimenopausal transition and permanently after menopause. As a consequence, women experience symptoms related to urogenital atrophy, vasomotor instability, neurocognitive dysfunction, accelerated bone loss, and cardiovascular disease. For some women, vasomotor instability and associated insomnia are disabling. Vasomotor instability causes symptoms of hot flashes resulting from disruption of temperature regulatory mechanisms and associated vasodilation. Three quarters of white women experience hot flashes during the perimenopausal transition, beginning on average 2 years before the cessation of menses. Eighty-five percent of these women continue to experience hot flashes for more than 1 year, and 25% to 50% for as long as 5 years. 1 Hot flashes usually wane over time, but in some individuals they may continue indefinitely. Although demographic studies are incomplete, hot flashes appear to be more common in African American women than in their white, Hispanic, Japanese, or Chinese counterparts. 2 Interestingly, detailed studies of Mayan Indian women revealed that they reported no symptoms associated with menopause, perhaps because of their cultural attitudes toward menopause. 3


This essay will analyze the multi-culture in three prospective. First, the controversy caused in the opposition between liberalism, communitarianism and ego in multicultural issues. Second, the influence of politics of difference and recognition in multi-culture and the relationship in the practical education of minority group in remote area. Five different educational types are brought out, including: compensation, difference adaption, recognition, general and reflection civic education. The controversies in education will be discussed in order to balance the irreconcilable difference and similarity. Third, after understanding the actual influences of multi-culture in minority groups' education, the essay provides four suggestions: A. If the culture in the community is a strong major culture, multiethnic education should be focused. B. A social-corporative-system is needed to overcome the injustice economic situation, also to pursue self-supporting economy. C. Use recognition education when the edge culture became the culture in school and community. D. Multicultural education can be seen as general education.


A considerable occurrence of functional gastrointestinal disorders (FGID) in childhood, their frequent combination between themselves, the risk of transformation into organic pathology together with high collagen content in the digestive organs require investigation of pathophysiological relations of the pathology with collagen dysfunction. Objective of the study is to investigate the role of collagen disorders in FGID pathophysiology and assess their effect on clinical development of irritable bowel syndrome. 63 children suffering from FGID have been examined. Irritable bowel syndrome was diagnosed as a leading functional disorder of all the children examined. Syntropic functional biliary disorders were found in (38,46±6,13) % patients. By the results of molecular-genetic examination genetic polymorphism of COL3A1 rs1800255 with prevailing the genotype G/А – 47,62 % (95 % CІ 35,04 – 60,2) was determined, that was most reliably found (р = 0,008) in children with syntropic functional biliary disorders and was associated with a wide range of comorbid pathology (р = 0,002) and pronounced dysplastic signs (р = 0,034).


Excerpt The purpose of this paper is to present a serologically proved case of Q fever and reemphasize the importance of considering this disease in the diagnosis of non-bacterial pneumonias. This ...


The NH?-terminal E-residue sequences of human and rabbit plasminogens were determined to be Glu-Pro-LeuAsp-Asp-Tyr-Val-Asn-X-Gln-Gly-Ala-. The cat plasminogen 12-residue sequence differed only in the 1st residue, in which aspartic acid replaced glutamic acid. The bovine plasminogen NH?-terminal 7-residue sequence was determined to be Asp -Leu -Leu -Asp -Asp -Tyr -Val-. The NH2terminal residue of dog plasminogen is blocked since the protein could not be sequenced. The NHZ-terminal 5-residue sequences of the isolated Scarboxymethyl heavy (A) chain derivatives of cat, dog, rabbit, and bovine plasmins (urokinase-activated) were determined and found to be homologous with each other and with the human S-carboxymethyl heavy (A) chain S-residue sequence. These NH2-terminal sequences were different from those found in the five mammalian zymogens studied, indicating a specific cleavage at the NHz-terminal end of each zymogen during activation at apparently the same position in the peptide chain. These sequences are also homologous with the human Lys-plasminogen NH&erminal sequence. The NH,-terminal Zl-residue sequences of the isolated Scarboxymethyl light (B) chain derivatives of cat, dog, rabbit, and bovine plasmins (urokinase-activated) were determined and found to be homologous with each other and with a previously reported human S-carboxymethyl light (B) chain ZOresidue sequence (ROBBINS, K. C., BERNABE, P., ARZADON, L., AND SUMMARIA, L. (1972) J. Biol. Chem. 247, 6757-6762). The human NH2-terminal Zl-residue sequence was determined to be Val-Val-Gly-Gly-Cys-Val-Ala-His-Pro-His-SerTrp-Pro-Trp-Gln-Val-Val-Leu-Leu-Arg-Arg-. The 5th residue previously reported as glutamine is incorrect and is cysteine in all the sequences. This cysteine is part of the hinge disulfide bond connecting the heavy (A) and light (B) chains of human plasmin. The evolutionary changes in this portion


Starting from the connotation, essential and features of humanist management, this paper puts forward some measures for carrying out humanist management in university library, and points out that only when the librarians participate the management, can the humanist management be carried out effectively in the library.


An efficient transformation protocol was developed for groundnut (Arachis hypogaea L.) plants. Precultured cotyledons were co-cultured with Agrobacterium tumefaciens strain LBA 4404 harbouring the binary vector pBI121 containing the uidA (GUS) and nptII genes for 2 days and cultured on an embryo induction medium containing 0.5 mg/l NAA, 5.0 mg/l BAP, 75 mg/ml kanamycin and 300 mg/ml cefotaxime. The putatively transformed embryos were transferred to the medium with reduced kanamycin (50 mg/ml) for further development. Prolific shoots developed from these embryos on a MS medium containing 0.5 mg/l BAP and 50 mg/ml kanamycin with a transformation efficiency of 47%. The elongated kanamycin-resistant shoots were subsequently rooted on the MS medium supplemented with 1.0 mg/l IBA. The transgenic plants were later established in plastic cups. A strong GUS activity was detected in the putatively transformed plants by histochemical assay. Transformation was confirmed by PCR analyses. Integration of T-DNA into nuclear genome of transgenic plants was further confirmed by Southern hybridization with nptII gene probe. A large number of transgenic plants were obtained in this study. This protocol allows effective transformation and quick regeneration via embryogenesis.


CARBOHYDRATE homeostasis represents a complex interaction between multiple humoral agents. In the normal person a fall in blood sugar initiates physiologic responses that reduce the blood sugar to ...


This paper addresses the Brain MRI (Magnetic Resonance Imaging) classification problem from a new point of view. Indeed, most of the works reported in the literature follow the subsequent methodology: 1) Discrete Wavelet Transform (DWT) application, 2) sub-band selection, 3) feature extraction, and 4) learning. Consequently, those methods are limited by the information contained on the selected DWT outputs (sub-bands). This paper addresses the possibility of creating new suitable DWT sub-bands (by combining the classical DWT sub-bands) using Genetic Programming (GP) and a Random Forest (RF) classifier. These could be employed to efficiently address different classification scenarios (normal versus pathological, one versus all, and even multiclassification) as well as other automatic tasks.


We study identification of ascending auctions with additively separable auction-level unobserved heterogeneity. Usual deconvolution approaches are inapplicable due to the lack of the highest bid; both unobserved heterogeneity and incomplete bid data contribute to the correlation among observed bids. We propose an identification strategy exploiting "within" independence of unobserved heterogeneity and private value. First, the ratio of two observed order statistics' characteristic functions identifies the private value distribution. Second, standard deconvolution with a known error distribution identifies the unobserved heterogeneity distribution.


One of the plants that contain flavonoid compounds is the Tetracera indica L. Merr plant which comes from the Dilleniaceae family and is known by the common name of site. Phytochemical tests on the part of the grading fruit indicate the presence of phenolic compounds, namely flavonoids, so it is necessary to isolate and identify the compounds contained in the grading fruit. Compounds 9, 12-Octadecadienoic acid (Z,Z), Flavone, 5,7-dihydroxy-8methoxy, and Hexadecanoic acid are three compounds with the largest content and are contained in all parts of Tetracera. indica. This experiment was conducted to determine the content and to analyze the content of flavone, 5,7 dihydroxy-8-Methoxy (wogonin) in the Tetracera indica L. Merr plant. This experiment was conducted in October 2018 to March 2019. Analysis of the wogonin compound was carried out using HPLC (Shimadzu LC20AD) equipped with a Luna C18 column. 5 μm (150 x 4.6 mm, Phenomenex), with a wavelength of 270 nm. Wogonin compounds were found in the Tetracera indica plant extract at a retention time of 18.053 minutes from the reference standard and extract using spike injection at a wavelength of 270 nm by the HPLC instrument in this study.


Success of the software development companies is mostly dependent on the best effort prediction. If the predictedeffort is somewhat correct, then the company can find relief from the great tension of hurrying up the employees to getthe job done within targeted time. There are many estimation methods, techniques and tools that are available. But itis very difficult to select the best one for a particular project. Each method has its own advantages and disadvantages.And also the effort estimation depends on various parameters. It is the responsibility of the project manager to select thebest tool for his project. Based on the historical data, the project manager can find effort value of the new project afterapplying some statistical methods and data mining techniques on that data. The main aim of this work is to reveal howmuch accurate are data mining-classification techniques on software project effort prediction datasets when we performanalogy based effort estimation.


【Objective and Method】Eighteen male China merino(Xinjiang type) with similar weight and age about 12 months were divided into three groups,6 sheep for each group,the group Ⅱand group Ⅲ were added by 2 g and 4 g sodium dodecylbenzene sulfonate(SDBS)respectively in their low-protein diet,the group Ⅰ wasn't added by SDBS as control group,the purpose is to study the effect of SDBS on the digestion and metabolism of sheep.【Result】The results showed that the digestion in diet of the DM,OM,CP,cellulose and calcium in control group was 852.02±26.90,791.25±23.89,52.52±2.15,264.50±13.72, 1.56±0.38(g/d),and when 2 g,4 g SDBS/d was fed,they were increased by 5.15%,21.64%;4.57%,21.64%;1.01%,15.44%;2.48%,24.69% and 5.77%,19.87%.The apparent digestibility of DM and OM in control group was 66.51±0.02,65.48±1.97,when 2 g,4 g SDBS/d was given,they were increased by 1.31%,5.83% and 1.31%,6.34%.The group Ⅱ have no significant effect on the protein digestibility,but the group Ⅲ increased by 6.63% compared with the control group.The average body weight gain and the retention of N,Ca was 133.04±35.93,5.57±0.72,(1.19±0.44)g/d,when 2 g,4 g SDBS/d was given,they were increased by 4.57%,7.84%;9.52%,23.34%;14.29%,30.25%.【Conclusion】The present study showed that SDBS could increase the intake,increase the amount of the digestible DM,OM,CP and cellulose when added different SDBS in their low-protein diet,increase the apparent digestibility of DM,OM and cell ulose when 4 g/d was given,but there was no significant effect on the metabolism of Ca,P either 2 g/d or 4 g/d was given.


Plasma catalysis is envisaged as an efficient method for improved gas stream processing, e.g., in VOC abatement, conversion of greenhouse gases or plasma-assisted deposition of materials. In this contribution, I highlight two nanoscale thermodynamic phenomena of importance for plasma catalytic processes, viz. the Gibbs-Thomson effect and dynamic phase coexistence.


Objective To investigate the impact of coronavirus disease 2019 (COVID-19) specified preventive and control measures on the distribution and resistance transition of Pseudomonas aeruginosa (P. aeruginosa) in uninfected hospitalized patients during the pandemic. Methods This retrospective study retrieved data from 316 P. aeruginosa isolates in the year pre-COVID-19 (n=131) pandemic and the year under COVID-19 specified preventive and control (post-pandemic year, n=185), compared the general characteristics, laboratory results, and antimicrobial susceptibility tests of P. aeruginosa between the two groups. Results Compared with the pre-pandemic year, the isolation rate of P. aeruginosa (14.35% vs 22.31%, P<0.001) increased, while the rate of drug resistant P. aeruginosa decreased significantly (29.77% vs 19.45%, P<0.001) in the post-pandemic year; Prescription of β-Lactams (30.5% vs 50.0%, P<0.01) also increased significantly. The resistance rates of P. aeruginosa isolates to ceftazidime (P<0.01), ciprofloxacin (P<0.01), and gentamicin (P<0.001) increased, whereas the resistance rates to piperacillin/tazobactam (P<0.01) and imipenem (P<0.05) decreased significantly. Conclusion The COVID-19 specified preventive and control measures have influenced the distribution and resistance transition of P. aeruginosa, further verifications are needed in future research.


The oxidation of alkoxytributylstannanes with copper(II) bromide in the presence of lithium bromide and t-butoxytributylstannane gave the corresponding carbonyl compounds in good yields under mild reaction conditions.


1Laboratory of Plant Chemistry and Organic and Bioorganic Synthesis, Faculty of Science, University Mohammed-V, Av. Ibn Battouta, Agdal, Rabat, Morocco 2Laboratory of Applied Chemistry of Materials, Faculty of Science, University Mohammed-V, Av. Ibn Battouta, Agdal, Rabat, Morocco 3Official Laboratory of Chemical Analysis and Research 25, Street Nichakra Rahal, Casablanca, Morocco *Corresponding Author: Miloudi Hilali, Laboratory of Plant Chemistry and Organic and Bioorganic Synthesis, Faculty of Science, University Mohammed-V, Av. Ibn Battouta, Agdal, Rabat, Morocco. Received: May 14, 2021; Published: July 29, 2021


A recent British trend has been the growth in HE photography courses with a concurrent emphasis on industry skills and commercial career outcomes. And, although pedagogic approaches to practical material have adapted, the theoretical material can be seen to be woefully lacking. Calls for a re-examination have indeed been made, but little has been offered that is not simply a rearticulation of the already dominant theoretical models. Rather than relying on the well-trodden models that promote photographer as visionary or emphasise meaning generation, it is proposed that photography theory should look to the breadth of approaches found in film studies, particularly in relation to commercial production. The two areas for development particularly advocated here are genre studies and industry analysis in terms of production and distribution. Since most commercially bound photographers work within industrial structures and constraints, both of these approaches would facilitate an understanding of creativity and innovation in this context. This would open up areas of photographic study that have thus far been largely ignored by academics and, further, would facilitate a closer relationship and dialogue between theory and practice in the educational context.


A 6-20 GHz reconfigurable triple-stub impedance tuner has been developed. It is based on a 11-switched MEMS capacitor network producing 2/sup 11/ different impedances. The measured and simulated impedance coverage is the widest ever measured to-date from any RF MEMS tuner. This network is most suitable for noise parameters and load-pull measurements of transistors at 6-20 GHz.


It is the fact of life in many developing countries that poor people are living and working in close proximity to toxic chemicals. In rural areas, exposure risks are associated with agriculture and other aspects of rural life. In urban areas, where many of the poor are moving and entering the informal sector of the economy, there are many new kinds of toxic hazards. The consequences-illness, and in many cases death are preventable tragedies. The report takes a critical look at the linkages between toxic exposures and poverty and implications for policy. It is the part of the Bank's increasing focus on the positive contribution that environmental policies can bring to the quality of life in developing nations.


Harry K. Wong , Rosemary T. Wong, (2009), The First Days of School – How to be an Effective Teacher, Singapore: CS Graphics Pte. Ltd. Ontario Public School Boards' Association, (2009), What If? Technology in the 21 Century Classroom, Toronto: Leading Education's Advocates Meg Ormiston, (2010), Creating a Digital-Rich Classroom – Teaching & learning in a Web 2.0 World, Bloomington: Solution Tree Press Mark Prensky, (2010), Teaching Digital Natives – Partnering for Real Learning, Thousand Oaks: Corwin Press Will Richardson, (2010), Blogs Wikis, Podcasts, and Other Powerful Web Tools for Classrooms, Third Edition, Thousand Oaks: Corwin Press Jeff Piontek, Blane Conklin, (2009), Blogs Wikis, Podcasts, Oh My!, Huntington Beach: Shell Education Mike Ribble, Gerald Bailey (2007), Digital Citizenship in Schools, Washington: ISTE Amy Benjamin, (2005), Differentiated Instruction Using Technology – A Guide for Middle and High School Teachers, Larchmont: Eye on Education Ontario Ministry of Education, (2010), Growing Success – Assessment , Evaluation, and Evaluation in Ontario Schools, Toronto: Queen's Printer for Ontario William M. Ferriter, Adam Garry, (2010), Teaching the iGeneration – 5 Easy Ways to Introduce Essential Skills with Web 2.0 Tools, Bloomington: Solution Tree Press Ontario Ministry of Education, (2010), Student Success – Differentiated Instruction Educator Package, Toronto: Queen's Printer for Ontario


Your Name: ______________________________________________________ Institution: ______________________________________________________ Position Title: ______________________________________________________ Primary Email: ______________________________________________________ Work Phone: ______________________ Home Phone: ________________________ Home Address: Street 1 _________________________________________________________ Street 2 _________________________________________________________ City ______________________________ State _______ Zip ______________ Country __________________________________________________________ Work Address: (Institution Name automatically included) Street 1 _________________________________________________________ Street 2 _________________________________________________________ City ______________________________ State _______ Zip ______________ Country __________________________________________________________ Mailing Address:  Home  Work Billing Address:  Home  Work Online Directory Address:  Home  Work Membership Category: FULL INDIVIDUAL MEMBERSHIP ASSOCIATE MEMBERSHIP  $80 – Part-time  $110 – Domestic (within US)  $105 – Salary of $20-29k/yr  $135 – International (outside US)  $136 – Salary of $30-39k/yr STUDENT MEMBERSHIP  $169 – Salary of $40-49k/yr  $53 (Proof of enrollment required)  $212 – Salary of $50-59k/yr BRIDGE-RATE MEMBERSHIP  $241 – Salary of $60-74k/yr  $53 (Limit: 2 nonconsecutive years)  $275 – Salary of $75-$89k/yr  $310 – Salary over $90k/yr  $75 – Retired


A method and system for improving the block access mechanisms defined in the current 3GPP standard is disclosed. The disclosed method proposes to improve the access blocking mechanism to receive the application-level block between the user terminal and the network. The disclosed method based on the priority level of the application in the granular category and the category of granular application, individually limiting or allowing access to the network for each of the requested application on the UE. The disclosed method is also to use the enhanced access blocking mechanism to support application-level blocking of the UE back-off timers, reject cause values, and accessing the stray terms (AS) and the non access stray term (NAS) set by the layer which specifies that process the access point name (APN). This improved access blocking mechanism makes it possible to provide services to other applications or blocked priorities from those unrelated applications. The disclosed method provides a mechanism for access control to the UE in the connected mode.


I. 1. Rhyton (Fig. 26, Plate 54c). Ht. 0·364. Ht. incl. handle 0·405. Diam. at tip 0·104. Diam. of spout 0·02. Broken but complete; the paint is slightly worn and the rim chipped. The painting is in orange and brown, with linear decoration on the lower part of the cone and interlocking zigzags above. The lip and the outer edges of the handle are outlined. The handle is of the raised metallic type and the lip overhangs slightly; the tip of the spout is offset a little to the rear. The buff clay without slip forms the ground for the decoration. The shape of the vase corresponds with Furumark's Type 199 (MP 71–72). The rhyton may be compared with the example from Palaikastro (Palaikastro 104 fig. 87a) and belongs to the L.M. IIIA 1 phase. For the zigzags cf. MP 182. I. 2. Piriform Jug (Fig. 26, Plate 54a, d). Ht. 0·29. Max. diam. 0·18. Diam. of base 0·06. Broken but complete, with well preserved black and brown decoration. The base is splaying and flat. A repeated S-pattern is incised at the base of the neck moulding. The lip is cut away above the handle. Argonauts are arranged in series around the shoulder, and a fish has been painted below the base of the handle. Bands around the neck join to form a chevron at the front. The edges of the handle are outlined. The argonaut is a development of the L.M. IA type and lacks tentacles.


Renewable energy source such as solar energy are acquiring more significance, due to shortage and environmental impacts of conventional flues. The use of photovoltaic system for converting solar energy into electricity is generally expensive. To minimize the cost and enhance the output,the PV panel should be operated at its maximum power point for all weather conditions. The output power of the PV panel is depends on amount of irradiation, temperature and the connected load. To extract maximum power from the PV panel, the load impedance should be equal to source impedance. Due to the mismatch between the source and load, panel is not operated at its maximum power pointMPP) resulting in lower generation of power therby decreasing the overall efficiency of the system. The aim of this paper presantation is to design and analyze a100KW maximum power point tracking based PV system in matlabsimulink at varying atmospheric conditions". A detailed modeling of a single diode solar cell is designed and analyzed. Further using series and parallel combination of modules, a 100KW solar PV plant is designed in matlabsimulink. The output is coupled with a Perturbation and Observation(P&O) based MPPT tracker to extract maximum power from PV plant. For the detailed analysis a DSP250W PV module specification were used. To highlight the proposed system performance, irradiation and temperature variation were applied in steps, results are analyzed and compared.


Degeneration experiments reveal that the vestibular nerve of the adult opossum distributes to an extensive and diverse area of the brainstem and, as in placental mammals, the traditionally named nuclei do not receive a uniform distribution of primary afferent fibers. Nevertheless, such nuclei as well as other nearby cell groups have been considered as vestibular since they share other mutual connections. Except for subgroups. "1", "g" and the nucleus suprvestibularis all of the vestibular subdivisions generally recognized in more specialized placentals (e.g., the cat) have been identified in the marsupial opossum.


OBJECTIVE
To assess the necessity of detecting the gene of cystic fibrosis transmembrane conductance regulator factor (CFTR) in Chinese men with congenital bilateral absence of the vas deferens (CBAVD).

METHODS
We detected the mutation of all the 27 exons of the CFTR gene in 9 patients with CBAVD by DNA sequencing, and compared the results using NCBI and Cystic Fibrosis Mutation Database.

RESULTS
Four novel missense mutations/variants were found in the CFTR gene of the CBAVD patients, which were submitted and accepted in the Cystic Fibrosis Mutation Database.

CONCLUSION
There are mutations or variants in the CFTR gene in Chinese men with CBAVD, and the mutational distribution is different from that in Westerners.


Multi-channel light-emitting diode (LED) light sources have been developed for various applications in lighting, but especially for spectrum-tunable lighting. However, how to select the optimal combination of LEDs for these light sources is rarely discussed. Unlike the negative-pruning process which operates by removing LEDs from a set of available LEDs based on an unrealizable negative-coefficient criterion alone, the proposed pruning process removes LEDs so as to minimize the synthesis error. This method not only produces the same optimal set of LEDs as those identified by the full-search method but also suggests when using phosphor-converted LEDs is beneficial. It does this by investigating the trade-off between the full width half maximum of the LEDs and the number of LEDs.


Introduction:Conventional understanding of knee kinematics suggests that the femoral component should be rotationally aligned parallel to the surgical epicondylar axis (SEA). In contrast, the balanced gap technique suggests the knee be balanced in extension and flexion to achieve proper kinematics and stability of the knee without reference to fixed bony landmarks. To investigate the functional flexion-extension axis (FFEA) when a balanced gap technique was used in the posterior-stabilized total knee arthroplasty (PS-TKA), the relationships between rotational alignment of the femoral component to the postoperative flexion gap balance and to the tibial mechanical axis were evaluated radiographically.Materials and Methods:In this prospective study, 63 consecutive knees in 50 patients were included with medial osteoarthritis undergoing a primary PS-TKA (NexGen LPS-Flex, fixed surface, Zimmer; Warsaw, USA). All subjects completed written informed consent. The patient population was composed of 8 men and 42 wo...


Objective
To explore the contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis in mouse congestive heart failure induced by Doxorubicin.

Methods
Doxorubicin (DOX) was administered intraperitoneally to rats, 2 mg/kg doses over 8 weeks. Echocardiographic and hemodynamics measurements were obtained at 8 weeks after treatment. Then left ventricular (LV) samples were collected. The successfully established rats were divided into 3 groups (Fu Shen Ke Li 40 mg/kg, 60 mg/kg, and 80 mg/kg). After 5 weeks post the operation, an echocardiographic was performed on all the rats under narcotism, Western blot to test the B-cell lymphoma-2 (Bcl-2), myeloid cell leukemia-1 (Mcl-1), Bcl-2-Associated X (Bax), Caspase-3, C/EBP homologous protein (CHOP), and 78-kDa glucose-regulated protein (GRP78), and reverse transcription-polymerase chain reaction (RT-PCR) to test the mRNA expression levels of Mcl-1, and NOXA.

Results
The left ventricular end-diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF) prompted modeling success The left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), and fractional shortening (FS) have been improved in high and middle groups of Fu Shen Ke Li. Compared to the model group, higher expression levels of Bcl-2, and Mcl-1 were, lower expressions of Bax, NOXA, CHOP, and GRP78 were (P<0.05) in 3 groups of Fu Shen Ke Li. Compared to the model group, there were higher mRNA expression level of Mcl-1 was , lower mRNA expression of NOXA was (P<0.05) in 3 groups of Fu Shen Ke Li.

Conclusions
Fu Shen Ke Li depresses endoplasmic reticulum stress, which can reduce the apoptosis of myocardial cells, and ultimately achieve the purpose of treatment of heart failure.

Key words:
SALVIA MILTIORRHIZA△/PD; GINSENG△/PD; SCROPHULARIA NINGPOENSIS/PD; Epirubicin/AE; Heart failure; Apoptosis; Endoplasmic reticulum; Stress


Part of a series of catalogues of British medieval manuscripts in the British Library, this volume is devoted to the Registrum Anglie.


The invention discloses a contrast medium tracking scan method and device. The contrast medium tracking scan method comprises the steps that the dual-energy scanning function is conducted for a circle at the position to be scanned, so that a group of dual-energy data are obtained; decomposition is conducted on the group of dual-energy data, so that a water base diagram and an iodine base diagram are obtained; based on the pixel values of the water base diagram and the iodine base diagram, a blood vessel area is located; whether the density of a contrast medium in the blood vessel area is larger than a first threshold value or not is judged, if yes, subsequent clinical scanning is conducted, and if not, a next circle of dual-energy scanning is executed. According to the technical scheme, when it is automatically judged that the contrast medium on a target portion reaches an ideal concentration, subsequent clinical scanning is started, and contrast medium tracking scan is automatically achieved.


A project is being conducted in English as a foreign language (EFL), involving eleventh graders in formal and non-formal learning contexts, in a Portuguese high school. The goal of this study is to examine the impact of cognitive tools and higher-order thinking processes on the learning of EFL and achievement of larger processes oriented to action, involving problem solving, decision-making and creation of new products. YouTube videos emerge as cognitive tools in the process. Final results show major differences concerning learners' achievements. Learners have developed higher-order processes oriented to action, in particular their ability to learn, to transfer the skills developed to different contexts and apply them effectively in EFL communicative situations. This paper discusses: a) major theories that support the integration of cognitive tools and thinking processes within the curriculum, focussing on the English language learning; b) some of the activities and materials; c) the final findings.


A study of the crystal packing of six derivatives of N-benzyl-2-phenylpyridinium bromide demonstrated the potential importance of synergism between π-stacking interactions and steric substituent effects in the determination of molecular orientations in an ionic lattice. N-Benzyl-2-phenylpyridinium bromide was substituted with 4-methoxybenzyl, 4-cyanobenzyl, 4-trifluoromethylbenzyl, 4-trifluoromethyl-2,3,5,6-tetrafluorobenzyl, and 2,3,4,5,6-pentafluorobenzyl. Nonangular para substituents on the benzyl ring gave rise to predictable changes in the solid state. These substituents anchored and aligned the molecules by complete or partial interdigitation. The increased stability of perfluoroarene/arene interactions vs arene/arene interactions were manifest in the presence of the strong ionic lattice. The fact that electronic perturbation in π-stacked oriented molecules in these crystals demonstrated partial orthogonality between the directional forces involved in the establishment of the ionic lattice and the m...


Traditional hop production on high trellis involves a lot of manual work. The seasonal preparation of the supporting wires that hop vines grow on requires manual fastening of pre-cut wire elements to the longitudinal cables. The work is dangerous, ergonomically uncomfortable, and often needs to be done under difficult weather conditions.


The huge tsunami triggered by an earthquake of magnitude 9.0 on March 11,2011 hit the east coast of Honshu,Japan,and caused serious social and economic losses.According to the characteristics of earthquake and tsunami disaster and the requirements of damage monitoring,a rapid disaster development detection process based on a decision level fusion of multiple features is designed.In this approach,each feature extracted from the original remote sensing images,including NDVI,NDWI,components of the principal component analysis and the independent component analysis,is used to derive a specific change map,and different change maps are then integrated by a decision level fusion algorithm to generate a synthetic change map with a higher reliability,which can be used for the damage assessment.Multi-temporal HJ-1A/B(environment and disaster monitoring and forecasting of small satellite constellation) images are processed by the proposed approach and used for detecting the devastated areas in east coast of Japan before and after tsunami.The experimental results confirm the feasibility and effectiveness of the proposed approach,and demonstrate the advantages of HJ-1A/B remote sensing data.This unsupervised change detection process can identify the tsunami-devastated regions quickly and efficiently,and provide the technical and decision support for the disaster emergency response and loss evaluation.


This article aims at reflecting on population mobility in the studies of Social Sciences. In Geography, it has a transdisciplinary nature which legitimizes the use of concepts such as mobility (of force) of labour and social mobility. These concepts bring up conceptual confusion and weaknesses to be overcome by instrumental theory of mobility which is contextualized in this study


This is HOAN's 17th circular to inform you and over 210 other members of HOAN about the activities of EASA's History of Anthropology Network and other developments in this subdisciplinary field. We report on 1. Past events, in particular eight HoA-related panels during EASA's 16th biennial conference in (virtual) Lisbon, 21-24 July 2020; 2. Network meeting of HOAN on 20 July 2020 and the new Network Convenors of HOAN; 3. Recent publications; 5. the Renaming Kroeber Hall at the University of California, Berkeley.


Virtual technology plays a pivotal role in the realization of the computer system's efficiency and improvement of performance. Through expounding the applications and working principle of the virtual CPU, virtual memory, virtual device, virtual file system in the computer system, we make a preliminary study of virtual technology in computer systems.


While sport compression stockings (SCS) have become increasingly popular, there is no regulatory norm as exists for medical compression stockings (MCS). The objective of this pilot study was to compare five SCS with respect to their pressure profiles ex vivo and in vivo, and in relation to German standards for MCS (RAL norm).


With the background of increased single-person households residing in a relatively downsized space due to the absence of household members, this study suggests the composition direction of multi-functional furniture design through the analysis on the frequency of furniture use and the preferred characteristics of multi-functional furniture in accordance with the composition type of residential space for single-person households. As research methods, first, the housing type of single-person households and the characteristics of multi-functional furniture are considered through literature/preceding researches. Second, a research tool is developed based on the considered contents, and a survey is conducted for singleperson households. Third, The type of housing and the frequency of furniture use and the preference of multi-functional flexible furniture characteristics are analyzed. Lastly, The composition direction of multi-functional flexible furniture design is suggested considering the frequency of furniture use, housing type, and multi-function flexible furniture characteristics. In this study, the furniture with high frequency of use in each housing type included drying rack, bed, mirror, and wardrobe. Regarding the characteristics of multi-functional flexible furniture, the preferred consciousness was shown in storage, folding, and combination. Thus, this study suggests the composition of customized multi-functional flexible furniture design considering the frequency of furniture use in each housing type and the preferred characteristics of multi-functional flexible furniture.


Objective: The study is focused on the analysis of visual consequences in patients who suffer from diabetic retinopathy. The patients involved were treated using pan retinal photocoagulation with or without sub-Tenon triamcinolone acetonide. Patients and Methods: The subjects were divided into two groups based on the treatment i.e. sub-tenon triamcinolone with pan retinal photocoagulation (Group 1) and pan retinal photocoagulation alone (Group 2). The cases were randomly distributed among both the groups. Change in visual acuity was considered to be the only major variable factor in this study. Visual acuity was checked after two months from the treatment and difference was measured from the standard readings. Results: The patients treated with a combination of sub-tenon triamcinolone and pan retinal photocoagulation showed improvement in visual acuity much greater than the patients who were treated with pan retinal photocoagulation only. The difference was statistically significant (p < 0.005). 73% of patients in Group 1 were having improved visual acuity as compared to only 6.6% of patients in Group 2. Conclusion: Sub-Tenon triamcinolone acetonide injection has proved to be an outstanding treatment in the deterrence of pan retinal photocoagulation. The visual acuity has improved much with the dose of the said injection and the visual loss caused by macular edema is minimized.


A vortex tube is a simple device which works as a refrigerator, also known as Ranque Vortex Tube, Hilsch Vortex Tube, and Ranque–Hilsch vortex tube. It is used to obtain desired hot and cold gas and is widely used for spot cooling in industry. In vortex tube, the effect of geometrical parameters on the cold flow temperature of vortex tube is still unclear, and effect of certain working gas is unidentified. Hence, the objective of this analysis is to determine the effect of length of the vortex tube, cold exit diameter and different working gas. 3 different tube lengths, 3 different cold exit diameters, and 8 different types of gas are used. Simflow, which is free software, is selected to analyse the effect numerically. From the results, it is clear that the optimum tube length, cold exit diameter, and working gas are L = 175 mm, d = 4 mm and helium, respectively.


Trait ascription studies have employed a number of response formats, varying the number of possible trait responses given on situation response. The proportion of trait responding that would occur with random responding matches closely the trait-responding frequency of actual subjects. It is hypothesized that subjects are conforming to demands implicit in the response format. This hypothesis was tested in a study that varied the number of both trait and situation options. Results showed significant effects of both manipulations, and trait responding was in all cases close to chance expectancy. It is concluded that the absolute frequencies of trait ascription in these studies are attributable to the methods used, and that no inferences can be drawn from them about natural tendencies in trait ascription frequency. The present results do not, however, call into question the validity of self/other differences in trait ascription.


Radiation impedance is one of the important parameters in designing efficient and wideband capacitive micro-machined ultrasonic transducer (CMUT) arrays. It determines how much acoustical power is generated in the surrounding medium given the membrane motion. Recently, considerable effort has been put to characterize the radiation impedance of CMUT arrays in conventional uncollapsed regime. However, the radiation impedance of an array of CMUT cells in collapsed state has not yet been investigated. To calculate the array radiation impedance in collapse mode, we first calculate the radiation impedance of a single cell CMUT. For the array case, the mutual impedances between the neighboring cells must also be taken into account. We consider an array of 7, 19, 37, and 61 cells placed in a hexagonal pattern and try to determine the radiation impedance for different degrees of collapse. We find that in the collapsed case the peak radiation resistance value is reached at higher kd values, where k is the wavenumber and d is the center to center cell spacing, compared to the uncollapsed regime.


One of the proposed functions of sleep is to conserve energy. We determined the amount of energy conserved by sleep in humans, how much more energy is expended when missing a night of sleep, and how much energy is conserved during recovery sleep. Findings support the hypothesis that a function of sleep is to conserve energy in humans. Sleep deprivation increased energy expenditure indicating that maintaining wakefulness under bed‐rest conditions is energetically costly. Recovery sleep after sleep deprivation reduced energy use compared to baseline sleep suggesting that human metabolic physiology has the capacity to make adjustments to respond to the energetic cost of sleep deprivation. The finding that sleep deprivation increases energy expenditure should not be interpreted that sleep deprivation is a safe or effective strategy for weight loss as other studies have shown that chronic sleep deprivation is associated with impaired cognition and weight gain.


Critical fluctuations above the Curie point in nickel have been studied by observing th relaxation of the free precession of positive muons. This work was prompted by the apparent discrepancy in nickel spin correlation time as determined by neutron scattering and by perturbed angular correlation (PAC) experiments. Up to 20K above the Curie point we obtain a temperature dependence in agreement with that determined from PAC. At higher temperatures the computed nickel spin correlation time becomes independent of temperature. The observed high temperature muon relaxation time of 16 μsec is very much shorter than expected from either the observed contact field at the low temperature muon site or from classical dipolar coupling to the muon nearest neighbors. The increased relaxation rate may arise from an enhanced pseudodipolar interaction.


Transactional Analysis Theory was presented by Eric Berne in 1957, in which he supposed that personal structure was formed by three elements: Parentego, Adult-ego and Child-ego. They juxtapose in a person's personality and influence people's transactional methods. According to their psychological feature, modern college students can be classified into three types: (1) Independent Students; (2) Love-lack Students; (3) Child Students. Under the guidance of TA theory, we can communicate with students by different egos, and then improve their psychological quality and cultivate the "Whole Person" wearing high IQ and EQ.


Carter Wall developed an interest in science at an early age yet struggled to find examples of women scientists and engineers beyond historical figures, like Marie Curie. A lack of relatable role-models didn't stop Carter from pursuing an undergraduate education and career rooted in STEM -- shorthand for science, technology, engineering and mathematics fields. Now, she plays a key role at one of largest solar developers in the Northeast. This is the first in the Energy Department's #WomenInStem video series. At the Energy Department, we're committed to supporting a diverse talent pool of STEM innovators ready to address the challenges and opportunities of our growing clean energy economy


The effects of temporal (time of day and season) factors and size, sex, female reproductive state and group size on the diel time-use of free-ranging red kangaroos (Macropus rufus) was examined. Particular emphasis was given to the effects on their foraging behaviour, with foraging divided into cropping, chewing and searching components. The study was conducted in semi-arid western New South Wales from July 1991 to March 1992, a time of deepening drought conditions in New South Wales. Group size had very little influence on the time-use of M. rufus. It was negatively but only weakly correlated with the proportion of foraging time spent chewing (chewing intensity). No significant differences in time-use were found between size classes of adult males (large and medium-sized males), females with or without pouch young, or females with different-sized pouch young (no visible young, small pouch young or large pouch young). Differences occurred between adult males, adult females and subadult kangaroos. These differences were mainly associated with their chewing and searching behaviour and were related to body size; as body size increased the proportion of time spent chewing and the intensity of chewing increased while the proportion of time searching and the proportion of foraging time spent searching (searching intensity) decreased. Neither the proportion of time spent cropping or foraging nor the proportion of foraging time spent cropping (cropping intensity) or the proportion of active time spent foraging (foraging intensity) differed between any size/sex/reproductive class. Temporal effects had a considerable influence on time-use. M. rufus were most active at night and in the few hours after sunrise and sunset. Seasonal changes in time-use were largely a result of changes in daytime behaviour. M. rufus foraged less and rested more during the day in winter than in spring or summer. There was no increase in the intensity or proportion of time spent foraging or cropping at night to compensate for the reduction in diurnal foraging. It is hypothesised that temporal variations in time-use were related to variations in weather and vegetation conditions.


The synthesis of Cu0 nanoparticles and Cu–protein nanocomposites is a great challenge. Here we describe a simple and convenient method for the synthesis of Cu–β-lactoglobulin nanocomposites using very cheap CuSO4·5H2O and the retinol binding model protein bovine β-lactoglobulin (β-lg) at pH 10.0 in ammoniacal medium. Then addition of hydrazine hydrates in the reaction mixture and heating the solution at 55 °C for 2 h resulted in the formation of hexagonal Cu–β-lg nanocomposite (average size 0.5 μm) containing the embedded Cu-nanoparticles as revealed from SEM and TEM analysis. The important feature of this method is that the highly stable Cu-nanoparticle present in the composites were synthesized without employing any inert atmosphere; decomposition of hydrazine hydrate generated the nitrogen in situ which produced the inert atmosphere for this reaction. Synthesis of this nanocomposite is justified by a docking study. The synthesized nanocomposite exhibits potential antibacterial activity against both Gram positive and Gram negative bacterial strains. Thus it can be employed in different medical applications and also in the preparation of various nanomedicines.


Abstract Thermolysis of 4-dimethylamino-2-phenyl-4-substituted 4H-1,3-thiazines leads to thioamide vinylogs or N-methyl 2H-3,4-dihydrothiazine by thermal rearrangement depending on the nature of the substituents.


A mini-type sewage sediment device is characterized by mainly comprising an upper vortex-shaped water channel cover (1), a container (2), a lower vortex-shaped water channel cover (3), a position-adjusting cylinder (5), rocking handles (4 and 6) and sludge valves (7 and 8). According to the mini-type sewage sediment device, the sediment efficiency is high and the cost is low.


Breast cancer therapies are associated with a risk of cardiac dysfunction, most commonly defined by changes in left ventricular ejection fraction (LVEF). Recently, the authors identified 3 classes of LVEF change after exposure to anthracyclines and/or trastuzumab using latent class growth modeling. The objective of the current study was to characterize the clinical, biochemical, and functional profiles associated with LVEF trajectory class membership.


The stereochemistry of lignan biosynthesis in Arctium lappa L. is regulated organ-specifically. (+)-Secoisolariciresinol [81% enantiomeric excess (e.e.)] was isolated from A. lappa petioles. In sharp contrast, lignans whose predominant enantiomers have the opposite absolute configuration to that of (+)-secoisolariciresinol [i.e., (−)-matairesinol (>99% e.e.), (−)-arctigenin (>99% e.e.), and (−)-secoisolariciresinol (65% e.e.)] were isolated from seeds of the species. The stereochemical diversity of secoisolariciresinol was demonstrated with enzyme preparations from A. lappa petioles and seeds. Thus, a petiole enzyme preparation catalyzed the formation of (+)-pinoresinol (33% e.e.), (+)-lariciresinol (30% e.e.), and (+)-secoisolariciresinol (20% e.e.) from achiral coniferyl alcohol in the presence of NADPH and H2O2, whereas that from ripening seeds catalyzed the formation of (−)-pinoresinol (22% e.e.), (−)-lariciresinol (>99% e.e.), and (−)-secoisolariciresinol (38% e.e.) under the same conditions. In addition, the ripening seed enzyme preparation mediated the selective formation of the optically pure (>99% e.e.) (−)-enantiomer of matairesinol from racemic (±)-secoisolariciresinols in the presence of NADP. These results indicate that the stereochemical mechanism for lignan biosynthesis in A. lappa varies with organs, suggesting that multiple lignan-synthesizing isozymes are involved in the stereochemical control of lignan formation in A. lappa.


ABSTRACT This work proposes the application of flexible alcoholic aqueous two-phase systems to manipulate the partition of caffeine. An optimization study was performed the caffeine partitioning towards top phase (60.0 wt% 2-propanol + 20.0 wt% K3PO4 at 303 K – Kcaf = 3.4 and RT = 89.1%) and bottom phase (60.0 wt% methanol + 17.5 wt% K2HPO4/KH2PO4 at 278 K – Kcaf = 0.06 and RB = 81.1%). These processes were evaluated by applying them to real biomass as guaraná seeds (purification factor (PF) = 6.59-fold) and coffee beans (PF = 3.24-fold) for the 2-propanol and K2HPO4/KH2PO4 system.


Through market research funded by the Joint Venture Agroforestry Program, it was proposed to test and adapt an innovative group model developed by the central Victorian landholder co-operative, SMARTimbers. The model is premised on delivering higher returns to farm foresters for speciality timbers common to their region by using an integrated supply chain and a single desk marketing structure.


The present invention by the addition of cyclic dimethyl ammonium on synthetic zeolites of the composition of the synthesis of zeolite or zeotype material having a very small grain size of 5-50 nm in size. In addition, the present invention is dealumination, ion exchange, and the other after the other, activated by a handle or functionalized micro-includes a mesoporous molecular sieve material, and the catalyst utilization. Nanocrystalline minutes synthesized by the present invention itself is to micropores (diameter <1nm), the molecular sieve crystals mesopores (2 <diameter <50 nm) and macro pores (50 nm <diameter) in between, including the presence since this will increase the molecular diffusion, the activity was improved significantly in function of the catalyst and the ion exchange resin seen in conventional zeolites. It also facilitates the diffusion and absorption of macromolecules alkylation of large organic molecules, exhibit very high reactivity, etc. acyl migration reaction. Nanocrystals, mesopores, macro pore zeolite.


Adapted and effective pest management strategies for the protection of irreplaceable culture heritage as well as for the prevention of damages in households and warehouses are based on reliable information about the presence and distribution of the pest organisms. Monitoring the webbing clothes moth Tineola bisselliella at thirteen outdoor stations in the broader area of Berlin give a first idea of their occurrence in an urban area and the hinterlands. The results demonstrate a seasonal abundance in the city and a missing of this species in the countryside. Data suggest a synanthropic occurrence of the webbing clothes moth rather than an invasion from natural reservoires. Possible molecular examinations on the species and subspecies level are presented to analyze the gene flow between populations and give an impression of species mobility as well as pathways of infestation.


In order to solve the questions of micro-polluted source water treatment,a pilot test on directly treating micro-polluted source water by submerged flat ultrafiltration membrane was conducted.The results show that the removal rate of turbidity is more than 99.0%,with the effluent turbidity of less than 0.1 NTU,the removal rate of CODMn is about 25.8% to 46.9%,with the effluent CODMn of less than 2.5 mg/L,and the removal rate of UV254 is relatively low,being 13.3%.The increment of ultrafiltration transmembrane pressure(TMP) has good linear relationship with filtration time.The air-assisted surface rinse can significantly reduce the average increase rate of TMP,and membrane cleaning performance improvement is marked.


Justification of a cause-and-effect relationship in environmental impact studies is complicated by inherent qualities of impact data. Lack of randomization and replication invalidate the use of inferential statistics for inferring a causal link, and place special demands on descriptive arguments for causation. Assembly rules for causal arguments have been developed in epidemiology and provide a rigorous structure for descriptive analysis. Explicit use of assembly rules for making causal arguments allows investigators to efficiently organize, study, and present available evidence. Within this framework, statistical tests can be used to determine if populations at study sites were different after the impact, but the establishment of a causal link between the impact and the observed difference is based on an argument. Causal inference by means of argument is consistent with the scientific method of strong inference and increases the likelihood of correct conclusions.


Super-outburst!  We present the X-ray data observed with Suzaku satellite.  We used "Catalogue of Cataclysmic Binaries, Low-Mass X-Ray Binaries, and Related objects" Edition 7.20 [8] . 1. Selected DNe from Catalogue of Cataclysmic Binaries[9] (1094 objects → 610 objects) 2. Selected DNe that are included in the field of view of XIS (23 DNe, 29 observations) 3. Removed proprietary data (17 DNs, 23 Obs.) 4. Removed following data a) Those with a nature different from DN by individual studies[10] (1 object) b) Those in globular clusters and unresolvable from other sources by Suzaku (1 object) c) Undetected by XIS due to the count rates (2 objects) 5. Finally, we obtained 13 DNe and 23 observation. Four DNe have multiple observations in different states. 3-1. Data Selection!


An IBM 7090 FORTRAN program was written for the preliminary design and cost estimation of unfired pressure vessels with or without a jacket. Both vessel and jacket designs conform to the 1959 ASME Boiler and Pressure Vessel Code, Section VIII, Unfired Pressure Vessels. Vessels and jackets from 5 in. pipe through 84 in. o.d. and 1/4 in. through 1 1/2 in. in metal thickness may be designed by this program as written. Total vessel cost is the sum of metal and fabrication costs, each on a weight basis. (auth)


In modern times, the collection of data is not a big deal but using it in a meaningful is a challenging task. Different organizations are using artificial intelligence and machine learning for collecting and utilizing the data. These should also be used in the medical because different disease requires the prediction. One of these diseases is asthma that is continuously increasing and affecting more and more people. The major issue is that it is difficult to diagnose in children. Machine learning algorithms can help in diagnosing it early so that the doctors can start the treatment early. Machine learning algorithms can perform this prediction so this study will be helpful for both the doctors and patients. There are different machine learning predictive algorithms are available that have been used for this purpose.


Light sources in the wavelength range below 300nm have attracted extensive attention due to their applications in instrumentation and in disinfection of water, air and surface. Nitride-semiconductor-based, light emitting diodes (LEDs) are of especially great interest due to numerous advantages compared to conventional mercury lamps. Although significant progress of more than 9mW of quasi-CW power around 260nm at room temperature has been achieved from devices with AlxGa1-xN heterostructures pseudomorphically grown on native AlN substrate [1], those devices still have relatively low photon extraction efficiencies (estimated to be around 4%). In particular, half of the generated photons are directed towards the p-contact and absorbed by the smaller bandgap p-GaN. The other half of the photons, which are directed toward the exit surface, will experience absorption in AlN substrate due to point defects which create states within the bandgap of the AlN material. In addition, only a small fraction of those photons actually reaching the exit surface will escape due to the relatively large refractive index difference between AlN and air resulting in a narrow escape cone.


Abstract The Republic of Korea (ROK) today faces the greatest security threat since the Korean War half a century ago. The military situation on the Korean peninsula has been remarkably aggravated following North Korea's nuclear test, and the agreement on deactivation of the Combined Forces Command (CFC) has jolted the roots of the ROK-U.S. combined defense posture. While the ROK and the United States were putting many endeavors into disabling the existing combined defense system, North Korea scored a series of nuclear and missile provocation during the past couple of years. Meanwhile, the Bush administration showed a major turn-around in its attitude toward North Korea since its nuclear test. Washington, which previously labeled North Korea as part of an "axis of evil," now considers the North a legitimate counterpart for negotiating peace and security on the Korean peninsula. The Roh administration also goes with the principle of "peace for peace" or "no war" on the Korean peninsula. "Improving inter-Ko...


Background Figure-disembedding is one of the most discussed visuo-cognitive functions, in which individuals with Autism Spectrum Disorder (ASD) have been reported to outperform non-autistic individuals. A local processing bias has been assumed to underlie such superior performance patterns. The aim of the current study is to investigate whether processing preferences can be modified by procedural priming. Method The current study used a procedural priming task (Navon figures) to induce more local or global processing in 25 autistic and 21 typically developing (TD) control participants, using hierarchical figures preceding the figure-disembedding task. Results Participants with ASD outperformed non-autistic individuals in the unprimed baseline task version. The performance was not modulated by priming in either direction (toward a local or global processing style) in both groups. However, the performance of TD control participants was improved by training to the same level as that observed in the ASD group. Conclusion Figure-disembedding performance in ASD is superior to that in TD control participants and robust against procedural priming or training. In contrast, performance in the TD control group can be improved up to the level of the ASD group. Any studies reporting superiority in individuals with ASD in figure-disembedding should consider training effects when evaluating group differences.


In the last years, there has been a quick increase in the development of genetic technologies with important economic, ethical or social implications which are provoking many questions of great relevance. Young students are immersed in news on Genetics and Molecular Biology, subjects that will be more and more common, and they will be demanded to make substantiated decisions. Nevertheless, generally, little is known about what young people know or think about these issues. The great social development that the Genetics is acquiring, their wide media coverage, the incorporation of this matter in the curriculum of secondary education, the difficulties found in the learning of genetic, are some of the reasons that make necessary a deeper investigation through a didactic perspective. In this work, aspects related to the education of the genetics have been analyzed from both the point of view of the formal education and from the informal one.


Objective The purpose of this paper is to elaborate the definition and feature of tacit knowledge and analysis the significance of the tacit knowledge in clinical medical education.Methods Analysis the characteristic of tacit knowledge,study the influence of tacit knowledge in clinical teaching and the effect of tacit knowledge of teacher in education.Results According to the characteristics of tacit knowledge,it is necessary to know the importance of tacit knowledge,to improve teaching skills and techniques as well as with new technology,to strengthen the teaching of tacit knowledge in clinical teaching.Conclusion Tacit knowledge is the important component of knowledge systems.Tacit knowledge is hard to be explained in words,it should pay attention to tacit knowledge during the education.


Basic Concepts from Molecular Genetics1.DNA Structure and Function Protein Synthesis Genetic Influences on Cell Growth, Cell Differentiation, and Gametogenesis Gene Expression4.Patterns of Inheritance Chromosomal and Mitochondrial Inheritance and Disorders Family History and Pedigree Construction Congenital Anomalies, Basic Dysmorphology, and Genetic Assessment Genomic Health Problems Across the Lifespan8.Enzyme and Collagen Disorders Common Childhood-Onset Genetic Disorders Common Adult-Onset Genetic Disorders Genomic Influences on Selected Complex Health Problems Cardiovascular Disorders The Genetics of Cancer Genetic Contributions to Psychiatric and Behavioral Disorders Genomics and Disease Management.


Editor,—In his annotation "NHS Direct: here and now",1 McLellan raises questions about the new service and highlights some of the criticisms levelled against it.2 We would like to offer some evidence in favour of NHS …


A composite TiP2O7/amorphous carbon material (C-TiP2O7) was prepared by an intensive mechanical mixing/solid-state synthesis method at 800◦C. Physical properties were characterized via powder X-ray diffraction, Rietveld refinement, SEM, BET and TGA. Electrochemical performance was evaluated in both a three electrode test setup and two electrode coin cells via cyclic voltammetry, electrochemical impedance spectroscopy and galvanostatic cycling tests. The C-TiP2O7 composite demonstrated excellent cycling performance in 1 M Li2SO4 when matched with LiMn2O4 as a positive electrode: when cycled at C/2 for 150 cycles, the capacity retention is over 91% with coulombic efficiencies exceeding 99%. The initial discharge capacity obtained at a C/10 rate is 91 mAh/g which is about 75% of theoretical capacity 121 mAh/g. The apparent diffusion coefficient of C-TiP2O7 composite calculated from cyclic voltammetry result is 3.5∗10−15 cm2/s. © The Author(s) 2015. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives 4.0 License (CC BY-NC-ND, http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is not changed in any way and is properly cited. For permission for commercial reuse, please email: email@example.com. [DOI: 10.1149/2.0071511jes] All rights reserved.


A method for generating an authentication message (316), receiving (102) an initialization message (303); Encrypting (104) the initialization message (303) using a first cryptographic process to obtain an intermediate message (312); and encrypting (106) the intermediate message (312) using a second cryptographic process to obtain the authentication message (316).


An infrared recording device and an infrared recording method of the present invention relate to the application fields of infrared recording device and the infrared detection. In the prior art, the corresponding recording of the infrared files and the information of the shot objects is not convenient. According to the infrared recording device and the infrared recording method provided by the present invention, the information of the particularly shot objects is assigned based on the pre-stored information of the shot objects, and at the recording, the information of the shot objects and the infrared files are in correlated recording, and the search and selection of the information of the shot objects are not needed or are easy, so that the existing problem is solved.


This paper argues the case for a more progressive approach to diversity and inclusion that incorporates a form of positive discrimination in the selection process: 'threshold selection'. It outlines the distinctive features of threshold selection and argues that it is an approach that resolves the tension between suitability and acceptability criteria, relies on high formalisation and transparency, can mitigate some of the self-serving bias among selectors and ties the selection needs to the goals of the organisation. In these respects, although controversial, threshold selection offers a thorough and systematic approach that is entirely consistent with the general tendency towards greater professionalisation of HRM.


I am delighted to provide readers of the European Heart Journal with an overview of scientific data relating to Coronary Intervention in 2012. This article aims to summarize the important publications and presentations; it includes a summary of the main interventional meetings (ACC, EuroPCR, ESC, TCT, and AHA) together with a selection of important publications from the major general and specialist journals.


The visual-audioizer is a patch created in Max in which the concept of fluid-time animation techniques, in tandem with basic computer vision tracking methods, can be used as a tool to allow the visual time-based media artist to create music. Visual aspects relating to the animator's knowledge of motion, animated loops, and auditory synchronization derived from computer vision tracking methods, allow an immediate connection between the generated audio derived from visuals—becoming a new way to experience and create audio-visual media. A conceptual overview, comparisons of past/current audio-visual contributors, and a summary of the Max patch will be discussed. The novelty of practice-based animation methods in the field of musical expression, considerations of utilizing the visual-audioizer, and the future of fluid-time animation techniques as a tool of musical creativity will also be addressed.


Metabolic syndrome has a high prevalence (about 22.4% in adult individuals) in developed countries. Inflammation due to obesity and fat accumulation is the most important factor in the progression of metabolic syndrome. In cells which have a receptor for insulin hormone, inflammatory mediators target the insulin signaling pathway and cause insulin resistance. Peroxisome proliferator-activated receptors are a group of ligand inducible transcription factors, whose activation can improve insulin resistance and their agonists such as Genistein, which seems to be useful in prevention of insulin resistance development. Genistein is one of the soy derived isoflavonoids that affects carbohydrate and lipid metabolism resulting in prevention of insulin resistance. The current narrative review has concentrated mainly on highlighting the usefulness of Genistein in the improvement of insulin resistance and therapeutic potential of it in both in-vitro and in-vivo models. Genistein can increase fatty acid β-oxidation, decrease lipogenesis and improve insulin resistance in hepatocytes. In adipocytes, Genistein prevents downregulation of adiponectin expression and facilitates the upregulation of adiponectin expression. In β-islet cells, Genistein initiates the special cascade which leads to proliferation of β cells, resulting in increased secretion of insulin. Based on findings of the studies, it can be concluded that Genistein can be a useful agent in prevention of de novo lipid synthesis as well as proliferation of β cells. In this way the development of metabolic syndrome can be prevented.


Genealogies are emic forms of social representation among many tribes in the Arab world. The formability of these genealogies for the purposes of politics and alliances is a common phenomenon. It becomes particularly obvious if one looks at the case of the Shākir tribe and its main divisions Wāilah and Dahm in the region of al-Jawf in northernmost Yemen. A comparison of their tribal genealogies and settlement areas in the tenth century CE, as described by the Yemeni scholar and historian al-Ḥasan al-Hamdānī, with their tribal structures and territories in the twenty-first century shows the enormous extent of change to which the Shākir, especially Dahm, have been subject in the past millennium. These changes seem to reflect in part the continuous immigration of external tribal groups to which the fringes of the Rubʿ al-Khālī desert have historically been exposed, and their inclusion into the local societies and thus the evolving genealogy of Shākir. These elements of residential discontinuity and mobility contrast with the more general pattern of territorial continuity and stasis prevailing in the central areas of Yemen. Yet the genealogy of Shākir proved to be more open towards these intrusive groups than towards the original inhabitants of the area itself: in contemporary al-Jawf remain descendants of ancient groups who are considered the aboriginal inhabitants of the area and who were neither given equal status to Shākir nor included into the Shākir genealogy. Seen in this light, the genealogies and semi-legendary traditions of al-Hamdānī's al-Iklīl also served to evoke a vision of community and of common identities among the heterogeneous societies of South Arabia and to legitimize them as heirs of a country and its history, which in parts was not inherently their own.


The computer analysis of the 34-m HA-DEC antenna by the IDEAS program provided the rms distortions of the surface panels support points for full gravity loadings in the three directions of the basic coordinate system of the computer model. The rms distortions for the gravity vector not in line with any of the three basic directions were solved and contour plotted starting from three surface panels setting declination angle. By inspections of the plots, it was concluded that the setting or rigging angle of -15 degrees declination minimized the rms distortions for sky coverage of plus or minus 22 declination angles to 10 degrees of ground mask.


From October to December 2019, 18 shigellosis cases (median age: 4.3 years, range: 0-21) were identified in the Reception Center for refugees/migrants on the Greek island of Samos. Fifteen cases (83.3%) were Afghani. Median time from arrival to symptoms onset was 53 days (40-101). Isolates from 14 cases, serotyped as Shigella flexneri 1b, and from three cases, serotyped as S. sonnei phase S (I), presented a multidrug-resistant phenotype. S. flexneri 1b isolates also produced extended-spectrum β-lactamases. Shigella flexneri 2a isolate from the remaining case was resistant to sulfomethoxazole, trimethoprim and pefloxacin. Improvement of hygiene and strengthening of laboratory investigation is needed.


1. Overall View of the ACORD Project.- 2. The Construction of Semantic Representations from F-STRUCTUREs.- 3. French Unification Categorial Grammars.- 4. TheControl of UCG Grammars.- 5. Anaphora Resolution.- 6. Text Generation from Semantic Representation.- 7. Graphics and Dialogue.- 8. Knowledge Representation and Conceptual Inferencing.


Purpose: By methodically synthesizing the body of knowledge on business-to-business (B2B) relationships and the long-term factors affecting these relationships, this research article aims to contribute predictions to future trends.
Design: The areas that required additional research were identified using a systematic review of the literature and textual analysis of keywords and abstracts. Additionally, convenience sampling was used in the article's analysis, collection of secondary data from reliable sources, analysis, evaluation, writing, and publication of the understanding.
Findings: This illustrative abstract map results from the review and shows the organizational level B2B relationship factors. The review highlighted the significance of additional research in B2B relationships, particularly in small manufacturing companies. Even though there have been numerous studies on the variables influencing business-to-business relationships, there is still room for more research into how enterprise attitudes toward service quality affect the development and maintenance of B2B relationships.
Originality/Value: To the best of our knowledge, it also offers a review of the literature on the factors influencing B2B relationships, explains the exogenous and endogenous factors, and suggests a concept map. The study adds to the growing body of knowledge on business-to-business relationships.
Paper Type: Review Paper.


The United Nations, the World Bank and the International Monetary Fund, created at the end of the Second World War, today operate on outdated political and economic foundations. They need to be overhauled before a crisis induced by globalization forces the changes required. The UN and its security council together with the Bretton Woods Institutions (BWIs) need urgent reform to meet globalization's challenges.


List of Entries Reader's Guide List of Figures and Tables Editorial Board Contributors Preface: A New Conception of the Knowledge Base of a Profession About the Editor Entries Volume 1: A-K Volume 2: L-Z Index


The magnetic charge and the Brandt-Neri stability conditions are studied for a class of spherically symmetric self-dual monopoles previously exhibited by McGlinn. It is found that there is a connection between the requirement of Brandt-Neri stability and the charge: namely, a solution with the smallest charge is often, but not always, Brandt-Neri stable. Most of these solutions which have a larger magnetic charge are not Brandt-Neri stable.


ADULT ADHD EPIDEMIC? We are witnessing a dramatic increase in the number of adults presenting with symptoms of attention deficit hyperactivity disorder (ADHD) and wondering if they actually have this disorder (Hagar & Goldstein, 2005; Roy–Byrne et al., 1997). The same increase is true at the college and university level (Learning Opportunities Task Force, 2002). Many of these adults have no prior diagnosis of ADHD, and may not be able to provide any information about childhood behavior to corroborate lifetime impairment. In such situations, a clinician not only has to differentiate between the symptoms of ADHD and those of other disorders when making a differential diagnosis, but also must be aware of the possibility that the person may be exaggerating or feigning these symptoms for secondary gain. The idea that individuals could be exaggerating or feigning symptoms of ADHD has only recently become a topic of interest. As Quinn (2003) points out, "malingering may be a potential factor for the difficulty in accurate diagnosis of adult ADHD" (p. 381). Currently, no tests exist to help psychologists determine the level of motivation or effort being put forth by students being evaluated for ADHD, nor is there a way to determine whether they are exaggerating their degree of impairment. This is troublesome, as recent research clearly suggests that about 50% of the variance in a neuropsychological test battery is explained by effort and cooperation (Green, Rohling, Lees–Haley, & Allen, 2001). Moreover, neuropsychologists such as Iverson (1995) assert that, in any cognitive assessment where financial or other personal gain is at stake, measures to evaluate effort and honesty must be included.


A method using non-sequential Zemax to produce a pixelated synthetic spectrum is described. This simulation was developed for the Keck Planet Finder (KPF) instrument, and will prove useful for engineering performance analyses (stability, stray light, order cross-talk, distortion, etc.). It has also provided a set of synthetic spectra to be used during the development of the data pipeline. Various aspects concerning the construction of the spectrum are described, including: converting a model from sequential to non-sequential Zemax, the creation of Zemax coating files for echelle blaze functions, and the generation of spectrum source files (solar, thorium-argon, incandescent, Fabry-Perot etalon and laser frequency comb).


Label smoothing is a regularization technique for neural networks. Normally neural models are trained to an output distribution that is a vector with a single 1 for the correct prediction, and 0 for all other elements. Label smoothing converts the correct prediction location to something slightly less than 1, then distributes the remainder to the other elements such that they are slightly greater than 0. A conceptual explanation behind label smoothing is that it helps prevent a neural model from becoming "overconfident" by forcing it to consider alternatives, even if only slightly. Label smoothing has been shown to help several areas of language generation, yet typically requires considerable tuning and testing to achieve the optimal results. This tuning and testing has not been reported for neural source code summarization – a growing research area in software engineering that seeks to generate natural language descriptions of source code behavior. In this paper, we demonstrate the effect of label smoothing on several baselines in neural code summarization, and conduct an experiment to find good parameters for label smoothing and make recommendations for its use.


This paper contains a derivation of general expressions for reducing Slater-Koster integrals ${E}_{\mathrm{ij}}(l,m,n)$ to the two-center approximation for orbitals $i$ (and $j$) having arbitrary angular momentum quantum numbers; $l$,$m$,$n$ describe the location of one center relative to the other. This has allowed the author to check the entries in Table I of the Slater-Koster paper and provides a means for extending these entries to include states of higher angular momenta. The derived general expressions are especially useful for machine calculations when a large number of particular expressions are required to be evaluated. As a collateral result the missing factors in the energy matrix elements along the $\ensuremath{\Delta}$ line for the face-centered cubic structure given by Slater and Koster and reviewed by Reitz have been noted.


Two women at the age of 62 and 42 years underwent secundum type atrial septal defect (ASD) closure with the recently introduced ATR I ASEPT II device (Cardia Inc, Eagan, Minnesota, USA). ASD closure devices of size 24 mm and 20 mm were implanted without complications. Intracardiac echocardiography demonstrated satisfactory device deployment. The first patient developed atrial fibrillation approximately 6 weeks after the procedure and therefore …


Introduction The detection and diagnosis of pNETs remains challenging. EUS and EUS-FNA has a significant role in the detection, precise localisation and cytological confirmation of pNETs. Methods A retrospective review of all pNET patients undergoing EUS-FNA between April 2003 and September 2011 was carried out to determine the efficacy of EUS-FNA in confirming pNETs and compare performance over two consecutive 4 year period. Results 10 patients (3% of EUS procedures for cystic lesions) with cystic pNETs and 44 (4% of EUS procedures for solid lesions) with solid pNETs were identified. Table 1 compares the size, demographics and diagnostic performance of radiology, EUS & cytology in solid and cystic pNETs. 17 and 5 solid and cystic pNETs respectively were diagnosed between 2003 and 2007 while 27 and 5 solid and cystic pNETs were diagnosed between 2008 and 2011. EUS-FNA diagnosis of cystic and solid pNETs has improved from 20% and 59% respectively between 2003 and 2007 to 100% and 81% respectively between 2008 and 2011. Overall, sensitivity of EUS cytology has improved from 50% to 84.4% (p = 0.015) during this period. Malignant potential of solid pNETs was higher (54.5% vs 20%) compared to cystic pNETs. Curative resection was higher in patients with cystic pNETs (80% vs 68%) compared to solid pNETs. Conclusion EUS & EUS-FNA is a useful test in diagnosing pNETs. Overall, the sensitivity of combined EUS imaging and cytology was significantly better compared to CT/MRI (p < 0.05) in detecting pNETs across all groups. Sensitivity of combined EUS imaging and cytology was significantly better compared to EUS imaging alone (p < 0.05) in the solid and combined pNET cohort of patients. Sensitivity of EUS cytology was significantly better compared to EUS imaging (p < 0.05) in the solid and combined pNET cohort of patients. Comparing the first 4 years to the second, there has been an increase in the number of cases of pNETs and statistically significant improvement in the diagnostic performance of cytology. Abstract PTU-179 Table 1 Combined solid & cystic pNETs (n= 54) Solid pNETs (n= 44) Cystic pNETs (n= 10) Mean Age (yrs) 61.3 61.5 60.2 Sex (Male %) AB59 AB64 40 Mean size of lesion in cm (range) 2.73 (0.7 – 9.5) 2.95 (0.7 – 9.5) 1.96 (0.8 – 5) Sensitivity of CT/MRI in detecting pNET (%) 33.3 ¹® 38.5 ¹® 10 1 Sensitivity of EUS imaging in detecting pNET (%) 51.8 * 57 * AB30 Sensitivity of EUS cytology in detecting pNET (%) 70.4 ® 73 ® AB60 Sensitivity of combined EUS imaging and cytology in detecting pNET(%) 81.5 *1 84.1*1 70 1 Note: * p < 0.05, ¹ p < 0.05, ® p < 0.05 comparison within columns Disclosure of Interest None Declared.


By means of transmission electron microscopy (TEM), the study on hypersthene megacryst and uralitized hypersthene from anorthosite complex of Chengde, Hebei Province of China shows that the layer silicate minerals such as talc and smectite would grow on the (100) under the condition of supergenesis. This kind of silicate is the product of the polysomatic reaction, and their evolution of growth from small to big was observed by TEM. In most cases, the layer silicate nucleus in the form of rhomb block firstly grow out of the interfaces of the augite exsolution lamellae in the hypersthene matrix. The boundary faces of the rhomb blocks are parallel to 210 of hypersthene. The small blocks could link each other in the form of veins, and further in the form of flakes. It is proposed that the growth of layer silicates is constrained by the nucleation mechanism of polysomatic reaction. The characteristics of the super-microstructure for the uralitized hypersthenes show that the polysomatic reaction from pyroxene to amphiboles is caused by the bulk reaction mechanism.


Abstract Vortex motion of a cylindrical quantum plasma containing degenerate inertialess electrons and strongly correlated, non-degenerate inertial ions is studied. The electron exchange–correlation and ion–neutral collisional effects are taken into consideration, along with vertical external magnetic field and radial electric field. Considering generalized viscoelastic momentum equation for strongly coupled ions in quasi-crystalline state, variation of different rotational characteristics along radial distance are discussed numerically. Existence of shear rotation is observed near both the core and the periphery of the vortex, which is found to be modified by ion–ion correlation, quantum effects of the degenerate electrons, the ion–neutral collision, as well as by the magnetic field. It is noticed that electron exchange–correlation potential and quantum diffraction play major roles in modifying the rotational characteristics. Vorticity and the rate of increment of enstrophy with respect to radial distance, diminish to zero towards the periphery of the vortex. Also, it is noted that the ion–neutral collision may be responsible for reducing the increment of enstrophy.


The chemical modification of multi-walled carbon nanotubes(MWNTs) was carried out with hexamethylene diamine(HMD),and the carbon nanotubes/carbon fibers(CF)/epoxy resin(EP) composites were prepared.This paper was aim to study the anti-aging properties and failure mechanisms of the CF/MWNTs-EP three-phase composites through detecting mechanical properties and morphology of fracture surface.The addition of MWNTs-NH2 in the composites increased the salt spray resistance properties,thermal-oxidative aging resistance and damp heat aging resistance under the given aging conditions.Performance of the interfaces between fibers and the matrix resin got improved due to the adding of MWNTs-NH2.Meanwhile,MWNTs-NH2could promote the curing of the epoxy resin and reduce porosity,resulting in significantly improving aging properties.As 1.0% MWNTs-NH2 was added,the salt spray resistance of three-phase composite material in the salt spray times of 72 h and 168 h was improved by 61.8% and 67.5% respectively compared with CF/EP composite.The thermaloxidative aging resistance of the three-phase composite materials in the thermal-oxidative aging times of 48 h,96 h and 168h was improved by 43.5%,48.5% and 41.7% respectively compared with that of CF/ EP composites.In addition,the damp heat aging resistance of three-phase composite materials in the different damp heat aging of 72 h and 168h was improved by 52.8% and 60.0% respectively compared with that of CF/EP composite.


In recent years, orthogonal frequency-division multiplexing (OFDM) system has become the most widely-deployed wireless technology due to the advantages of high system capacity and efficient spectrum efficiency. Nevertheless, one of the most serious concerns of the OFDM system is the synchronization problem. For example, OFDM is very sensitive to inter-carrier interference (ICI). If the ICI can't be properly compensated, system performance will be degraded dramatically. Besides, if the receiver cannot predict the arrival time of the OFDM symbols correctly, it will result in the rising of the bit error rate (BER) of the received symbols. In the conventional pilot-based synchronization, it has to pay the price of reducing the system throughput due to the pilot insertion. In this paper, a blind synchronization method is proposed via using the inherit repetitive feature of the CP-based OFDM symbol. Results show that the proposed blind synchronization method can have the best BER performance among the compared literary blind synchronization methods.


Joseon was a society whose dominant principle of social management was Neo-Confucianism, therefore the perception of geomancy, which is the study of divination, was negative on the whole. The mysterious aspects immanent in geomancy itself provoked criticism by many Confucian scholars. However, in a Confucian society stressing the practice of 'filial piety', burying the corpse of one's ancestor at a propitious site was an obligation of the descendant. Accordingly, there was room in which the theory of geomancy could be accepted. Geomancy of tomb was mainly accepted in relation to the selection of royal tombs. Song Si-yeol was a typical case. However, these cases were rare. Geomancy of house, employed in the selection of villages or dwelling sites, was more favorably received. Nevertheless, most Confucian scholars had a negative view of geomancy. While they took advantage of geomancy in selecting propitious burial sites for ancestors, they didn't accept the theory of geomancy whole-heartedly. Since the former Joseon period, a criticism was raised about the theory of geomancy in relation to the construction of royal tombs. During the latter Joseon period when the vice of geomancy became a serious social problem, criticism of tomb-related geomancy was focused on the "feeling the same energy" theory or the theory of fortune and misfortune. Realist scholars such as Jeong Sang-gi, Yi Ik and Jeong Yak-yong led the criticism.


Objective: To study the reliability and validity of an odor identification test. Methods: The data come from an epidemiological cohort including 1146 non-Hispanic Caucasian, 86 Hispanic, and 12 other participants at the baseline visit (73.4% female). We tested the fit of each of three neurobiologically plausible models (validity) for responding on a 12-item odor identification task using confirmatory factor analyses (CFA); five model fit indices were assessed for each run. CFA testing fit over time (reliability) was planned for the measurement model that was found to fit across groups at the baseline visit. If a model was not found for the baseline visit, the test would be deemed 'not invariant' over group, and not tested over time. In this case, we planned a post hoc Rasch analysis to further study test validity; and a multi-trait, multi-method analysis (MTMM) of the entire test battery to study reliability in terms of other, valid, cognitive and neuropsychological functional assessments. Results: Nearly 70% of the variability in odor identification scores is error, a result that was replicated over four independent samples at the baseline visit. A core of 30% of 'signal' from the task was identified over time (via Rasch modeling) but was explained fully by global cognition (replicated over time). Conclusions: 'Odor identification' as a construct cannot be reliably or validly measured over time or group. Multiple hypothesis-driven methods and replications show that this test provides no information that a global cognition score does not also (more validly and reliably) provide.


report issued by the Congressional Budget Office (CBO) on October 13, 2004 set in motion a national debate on the economic value of disease management (DM) programs and sent shock waves through the industry with the statement that "there was insufficient evidence to conclude that disease management programs can generally reduce overall health spending."1 The Congressional Budget Office left little doubt, however, that positive and credible evidence exists in the peer-reviewed literature regarding the clinical health benefits of such programs. These "mixed messages" from a respected independent source (CBO) raise a question for private sector purchasers: How should employers proceed with implementation of DM or similar proactive health interventions for their employees, retirees, and family beneficiaries? This position paper addresses that question.


Although Nova Scotia produces only 2.8% of Canada's total greenhouse gases (GHG), it has the fourth highest per capita emissions. These emissions come largely from electricity generation and transportation sectors. This is because fossil fuels are the main sources of electricity generation and even in the cleanest GHG reduction scenario fossil fuels will still contribute 60% of the electricity generation in 2020. In addition, Nova Scotia is the sixth highest province in terms of number of cars per capita, at 0.59 cars per person. However, using vehicle-to-grid (V2G) technology, these cars can have the potential to help the power utility and transportation sectors decrease their GHG emissions and at the same time allow an increase in the renewable sources serving the province. This paper analyzes how the province can benefit from V2G technology in the future.


Aim The aim of the study was to investigate data from patients suffering from chronic spontaneous urticaria refractory to conventional therapy, and to document outcomes of omalizumab use. Material and methods We conducted a single-centre retrospective study with 175 chronic spontaneous urticaria patients who were treated with 300 mg omalizumab subcutaneously every 4 weeks for at least 6 months. Efficacy, factors affecting outcome, and complications were examined. Results The complete response rate was 70.9%. Minor complications were observed in 12% of our patients. Anaphylaxis occurred in 1 patient as a major complication. We did not notice any clinical or laboratory factors predicting response to omalizumab treatment. Conclusions The findings show that omalizumab is effective and safe for the treatment of chronic spontaneous urticaria with a dosing of 300 mg/month subcutaneously. However, due to 1 case of anaphylaxis in this small group, we must still remind practitioners to be alert for this possible complication.


: Paper work proposed a new 2^n+1 modulo multiplier for dual key IDEA encryption in the design which generates less number of partial products (≤ n 2) and the less area at very high speed. The multiplication is based on Wallace tree along with specialized shifting. Coding with different combinations of eight rounds is been done at gate level i.e. fully dataflow modeling style for high throughput.. New modulo multiplication is been proposed in which multiple patterns can be done with less area. The string matching module is coded and functionally verified using VHDL language targeting Virtex IV pro FPGA and performance measures in terms of speed and resource utilization. Our work is mainly based on designing an efficient architecture (IP) for a cryptographic module for secure data trafficking and a network intrusion detection system for a high speed network. The complete designs are coded using VHDL language and are verified using Xilinx-ISE simulator for verifying their functionality.


Weekly didactic conference in emergency medicine education has traditionally united residents and faculty for learning and fostered community within the residency program The global pandemic Coronavirus Disease-19 (COVID-19) has fueled a rapid transition to remote learning that has disrupted the typical in-person format To maintain ACGME1 educational experiences and requirements for residents in a safe manner, many residencies have moved to videoconferencing platforms such as Zoom?, Teams?, and WebEX ?


The slideway design is the key in designing the disc vibrating feeder, however, a reliable and theoretical guidance has not come into existence, which greatly restricted the appliance of CAD(Computer-aided design). Based on the similarity principle and exist code system, a new coding method applicable to slideway design is brought forward. More detailed information about the parts could be supplied by the new coding system, which makes the design more convenient, simple and accurate with the subjoin of the initial and targeted codes.


In his series of works on movement phenomena in Modern Irish (Irish, hereafter), James McCloskey has shown the nature of movement in this language, which in turn suggests the nature of movement in human languages. In Irish, there are three COMPs: go/gur 'that(nonpast)/that(past),' aL (direct relative marker), and aN (indirect relative marker). McCloskey (2002) shows that there are five patterns allowed in COMP alternation, shown in (1)-(5), where the meaning of (1)-(4) is the same.1 In this paper, we use go as the default symbol for go/gur 'that(non-past)/that(past).'


We report on the photoinduced changes of the electronic properties of YBa2Cu3Ox (x ≈ 6.6) thin films, focussing on the electrical anisotropy in the normal and the superconducting state. The latter was determined from magnetoconductivity measurements, performed before and after light excitation, and fitting the experimental results to the Aslamazov–Larkin theory of superconducting order-parameter fluctuations. The normal-state anisotropy σab/σc was calculated from resistance measurements carried out on samples grown on vicinal substrates. We observed that the photodoping process enhanced superconducting coherence lengths ξc(0) and ξab(0), but reduced the superconducting anisotropy ξab(0)/ξc(0) at all studied temperatures. In contrast, σab/σc was enhanced by photodoping at low temperatures, but reduced at high temperature. Our results strongly suggest that two different mechanisms contribute to the photodoping process, with one affecting only the normal-state properties.


Recent large capital oil sands construction projects have all experienced significant cost overruns. There are a number of reasons for these overruns, some of which are listed in this article. This article provides a review of recent experiences and challenges in delivering mega oil sands projects in Alberta. In addition, this article focuses on the front-end loading (planning) phases 1, 2, and 3 and describes the effort needed to deliver mega projects, provides schedule comparisons of key engineering milestones, and analyzes scope changes and contingencies.


We study the axial anomaly problem in a non-Abelian topologically massive BF model with fermion coupling. The fermion is coupled to the vector and the tensor gauge fields in a non-minimal way.