Lurbinectedin is a selective inhibitor of oncogenic transcription. Reversible myelosuppression is its most relevant toxicity. Pharmacokinetic‐pharmacodynamic analyses were conducted to characterize the time course of absolute neutrophil count and platelet count recovery and to detect and quantify the effect of relevant covariates in patients with advanced solid tumors treated with lurbinectedin. Absolute neutrophil count, platelet count, and lurbinectedin total plasma concentration were assessed in 244 patients treated with lurbinectedin with varied dosing schedules and doses. A reference extended semimechanistic pharmacokinetic‐pharmacodynamic model of myelosuppression was used. Granulocyte colony‐stimulating factor (G‐CSF) administration was modeled as a dichotomous covariate, and platelet transfusions were included as a bolus dose into the last compartment of the model, representing the central circulation. Final models were suitable to describe the time course of absolute neutrophil count and platelet count recovery. A lurbinectedin dose of 3.2 mg/m2 every 3 weeks can be administered without primary prophylaxis with G‐CSF. G‐CSF followed by ≤2 dose reductions of 20%, if needed, gradually reduced grade 4 neutropenia from cycle 3 onward. BSA‐based dosing reduced the incidence of grade ≥ 3 thrombocytopenia. One‐week dose delays because of low absolute neutrophil count occurred in 3.5% of patients, thus supporting every‐3‐week administration. CYP3A inhibitors produced absolute 11.0% and 6.2% increases in grade ≥ 3 neutropenia and thrombocytopenia, respectively. Neutropenia and thrombocytopenia after lurbinectedin administration to cancer patients are noncumulative, reversible, short lasting, and clinically manageable with secondary prophylaxis of G‐CSF or platelet transfusion and, if needed, dose reductions.


Review of: Losos, J. B (ed.). 2011. In the Light of Evolution. Essays from the Laboratory and Field. Roberts and Company Publishers. 330 pp. ISBN: 9780981519494; $59.95 HB. Have you ever wondered what evolutionary ecologists do? What sorts of questions drive them and how do they approach the answers to these questions? Are you interested in understanding patterns and phenotypes seen in nature? Are you wondering what to do with the next 20 years of your life? If you answered yes to at least two of these questions, then I recommend that you read "In the Light of Evolution," a volume of 17 essays edited by Jonathan Losos. He has brought together a loosely connected set of individuals, many from Harvard, where he works, together with others who he has collaborated with, shares interests with, or simply admires, to write about their obsessions. Yes, for the most part, these are people who obsess and in doing so they have illuminated aspects of nature that were in the dark prior to their probing. They have helped us understand their small part of the world in the light of evolution and thereby provide us with parts of a framework that can be applied to other systems. As I tell my students in my evolution course, it is worth trying to see the world through the eyes of an evolutionary biologist, which is what this volume is all about and something I hope my students can learn to do. Many of the essays in this book differ from traditional chapters on any given scientific topic, because the focus is on how answers are found as much as on what the answers are. On display are the inspiration, perspiration, and motivation of the individual researchers. This includes the four essays that discuss Darwin and/or Wallace, two eccentric individuals who profoundly changed how we view the natural world. In the essay on Darwin by Janet Browne, she weaves aspects of Darwin's upbringing, his travels, his home life, and his beliefs throughout, and thereby brings the humanity of the man and his writing to the fore. Importantly, both she and Carl Zimmer (in his essay on researchers of microbes) note that Darwin was not only an observer, but also a lover of experiments and their interpretation, and hence the "theory" of evolution by natural selection was the product of a naturalist/experimentalist. The importance of observation is also highlighted in the essay by Marlene Zuk and Teri Orr, who point to the disagreement between Darwin and Wallace on whether female choice, as a component of sexual selection, existed. Apparently Wallace felt that ornamentation of males was a consequence of their relatively heightened vigor compared to females. All Darwin had to go on at the time were patterns of ornamentation, rather than experiments, but as this essay points out, he remained convinced that female choice was involved in male ornamentation until the day he died. Michael Ryan's essay, which is devoted to the question of whether female choice has influenced the mating calls of tungara frogs, shows how far we have come. It outlines an impressive set of field observations rich in the ecology of the frogs, experiments, and knowledge of the phylogeny of the genus that allows him to say yes, female choice has heavily influenced the evolution of male mating calls.


Among infrastructure diagnostics, the maintenance of Transportation Tunnel (TT) is of paramount importance. On the one hand, a predictive maintenance process would allow for safety compliance, preventive corrective actions, and increased lifetime for the asset, which results in improved efficiency of the overall infrastructure. On the other hand, existing methods to perform diagnosis and detection of these anomalies are inexpensive and time-consuming. Thus, ETS and RMT foresee the development of deep learning-based methods for the segmentation of defects on TT images. This stands as the technological pillar of two innovative ETS projects: the innovative multi-dimensional survey system (ARCHITA), and a new approach for the Management and Identification of the Risk for Existing Tunnels (MIRET). The focus of this communication is the segmentation of superficial detachments on data of concrete type Transportation Tunnels, using convolutional neural networks trained in an adversarial fashion.


Black phosphorous is a layered material having a high capacity of 2596 mAh/g as a battery electrode, however it suffers from cracking due to high volume expansion during lithiation. These cracks causes loss of electrical contact in the whole material, therefore capacity fades after further cycles of charging and discharging. One needs a support material which would not crack with lithiation of phosphorous in order to keep the electrical contact of the material. Here, we considered phosphorene sandwiched between graphene layers. By using density functional theory, we calculated voltages of lithiation, sodiation, and potasiation of black phosphorous and phosphorene-graphene heterostructure which compares well with the experimental results. We found low voltages for both black phosphorous and phosphorene-graphene heterostructure therefore these materials can be used as an anode electrode in lithium-ion, sodium-ion, and potassium-ion batteries.


The processes of formation of microlenses in photosensitive silicate and germanate glasses have been studied. A series of successive operations with samples of photosensitive glass activated by silver and cerium ions: irradiation, photolithography, secondary heat treatment, diffusion and ion exchange lead to the formation of various profiles on the glass surface, including convex or concave lens surfaces. On the basis of this effect, a promising technology for the production of raster microlenses and lenses for various optical devices and video cameras of a robotic system was developed.


A flow is observed in the pipe for the horizontal section of slotted screen completion and inflow control device (ICD) completion, and an annulus flow exists between the pipe and the borehole wall. Based on the principles of mass conservation and momentum conservation, a model for variable mass flow in an oil reservoir to simulate wellbore–annulus–reservoir state in the horizontal section of slotted screen completion and ICD completion is proposed. Consequently, based on the newly established formation transient seepage model and wellbore and annulus variable mass flow model, an accurate prediction of the production rate of a horizontal well as well as optimized design parameters for slotted screen completion and inflow control device (ICD) completion are achieved. The predicted flow profiles of the established model are confirmed using the simulation software from Computer Modeling Group Ltd. When external casing packers are not considered, findings show that the predicted production rates of both slotted screen completion and ICD completion, which are obtained using the variable mass flow models without annulus flow modeling, are higher than the rates obtained using the variable mass flow models with annulus flow modeling. Both models show that the pressure profile and flow profile of the borehole wall are more uniform in wellbore–annulus–reservoir in horizontal wells. The flow model for horizontal wells with annulus flow modeling should be established to improve the accuracy of the predicted production.


Processes of democratization in Indonesia occur at a rapid pace in many areas of public discourse. It is therefore necessary for the education system to keep abreast of the changes in community. Demand for the political renewal of the society exemplifies democratic processes in its structures and processes as well as preparing students to understand democracy. This article argues that schools and other educational institutions need to demonstrate open and critical democratic processes in the way that they operate as a prerequisite for teaching students how to adopt the roles of responsible citizens within a truly democratic environment. It explores strategies that teachers may adopt to democratize their curriculum and pedagogy


Abstract : Who serves in the military? Representation has always been an important public policy issue. From the recruiting perspective, the services want to know where the market is and where to place resources. They also want to know how the market is evolving to plan for the future. Military recruiting is in the midst of several "sea changes". The most notable of these has been the decline in the numbers of new recruits in recent years. Enlisted recruiting is now stabilizing at around 200,000 recruits annually, down from 278,000 in 1989, the last year prior to the post-cold war draw down. However, the decline in numbers recruited was accompanied by an increasing focus on high quality recruits, where high quality is defined as high school graduates with test scores at the 50th percentile or above on the Armed Forces Qualifying Test. Rather than reduce recruiting resources, the services have increased quality standards. High quality enlistments today constitute over two-thirds of all recruits (Office of the Assistant Secretary of Defense, 1995).


Monolithic mayenite with well-defined macropores has been successfully synthesized from ionic precursors via a sol–gel process accompanied by phase separation. The addition of propylene oxide (PO) to the starting solution leads to homogenous gelation and modifies the gel skeleton, whereas the addition of poly(ethylene oxide) (PEO) induces phase separation. Glycol acts as a chelating agent to suppress the precipitation of Ca2+ ions, and formamide works as a drying control chemical additive to enhance the drying behavior. Appropriate amounts of solvents, PEO, and PO allow the formation of calcium aluminate gels with co-continuous macroporous structure. The reaction mechanism of the sol–gel process of the Ca–Al–O system is also investigated by TG-DSC, FT-IR and NMR. The dried gels are amorphous and the crystalline phase Ca12Al14O32Cl2 forms after heat-treatment at 1000 °C in air, while the macroporous structure is preserved. The resultant monoliths before and after heat-treatment possess both high porosity and smooth and dense skeletons.


Associate production of the Higgs boson with other particles is crucial to eval- uate the consistency of the properties of the new discovered particle with the Standard Model (SM) expectations. In particular, associate production of the Higgs boson with a pair of top quarks (ttH) allows to directly access the Higgs-top coupling, which is im- portant to understand if the top quark, given its large mass, plays a special role in the electroweak symmetry breaking mechanism. The most recent CMS results on the search for a Higgs boson produced in association with top quarks, using the full dataset recorded at the LHC from pp collisions at centre of mass energies of 7 and 8 TeV, are presented. The Higgs decays studied cover all major decay channels, such as b¯ b, γγ, ττ.


This paper analyzes the need for the minutiae in secure personal identification, despite the advent of computerized systems, whose knowledge is diminishing by the general public and will be among the experts on the identification, more interested in implementing new technologies in scientific knowledge.


Background: The current definition of obesity implies a rise in total body fat, which may only be evaluated through an examination of body composition. Body Mass Index (BMI) cannot detect percent body fat (BF%) effectively, prompting the need for novel, simple, affordable, and resource-constrained methods of body fat assessment and measurement.

Objective: To determine the correlation of BMI and BF% estimated by BIA in children of Karachi

Methods: This cross-sectional study was performed in a school located in Karachi. The study was conducted from January to April 2023. The permission to conduct this study was taken from the National Institute of Child Health and School Administration. Healthy children of age 6-15 years of either gender were enrolled in this study.

Results: Total 132 children were studied with a mean age of 10.8 ± 2.5 years. The age range was 6-15 years. There was almost equal representation of both gender with 50.8% males and 49.2% females. Median weight, height, BMI, and BF% of study subjects were 30.5 (IQR=23.4-42.4) Kg, 139.5 (IQR=128-153) cm, 15.4 (IQR=13.8-17.6) Kg/m2 and 10.2 (IQR=6.1-16.7) % respectively. A significant strong positive correlation was seen for overall data (rs=0.645, p<0.001). Out of 132 observations, concordance was seen in 46.2% of observations yielding a weighted agreement of 0.2961 which was significant.

Conclusion: This study analyzed that there was a strong positive correlation between the two body measures. However, the classification in terms of BMI and BF% ranges showed a difference for the same individual with slight agreement. The finding for the Pakistani population should be validated in a larger study.


An active notch filter for interference rejection at C band is presented. In the design, a sharp notch, typically -50 dB for the entire C-band, is synthesized by subtracting BPF output from all-pass output. Unlike prior works, notch attenuation does not depend on the Q of the BPF LC tank. The proposed filter has been fabricated in a 0.13 μm SiGe BiCMOS process. Measurement results show 0~1 dB gain, 8~10.8 dB NF, and -6~-9 dBm IP-1dB in the pass band at 4-8 GHz. The filter draws 20-27.6 mA from a 3.3 V supply and the die area is 0.63×0.63 mm2.


Excellent squeezing in intracavity second-harmonic generation has been predicted to occur on cavity resonance in the output intensity fluctuations. Cavity detunings cause laser phase noise to couple in and reduce the squeezing observable. Here we consider the effects of laser phase fluctuations on the output-squeezing spectrum. Laser phase noise is modeled as an Ornstein-Uhlenbeck (colored-noise) Gaussian stochastic process and its effects are compared with the white-noise limit. This indicates that the white-noise model may qualitatively overestimate the deleterious effects of laser fluctuations on sideband squeezing. We compare our results with the recently reported experiment of Pereira /ital et/ /ital al/. (Phys. Rev. A 38, 4931 (1988)) and present an analysis of the empty cavity for comparison.


This work presents an efficient method to quickly calculate with good accuracy (about 5%) the solidification time of an injected semi-crystalline polymer slab. Under some hypotheses this polymer can be considered as a phase change material with a constant phase change temperature. We use a noteworthy property established on the ratio between the thickness of a solidifying phase change finite medium and the solidified thickness in a semi-infinite medium. The knowledge of this ratio enables to predict analytically the solidification time in a 1D finite medium. This ratio can be parameterized as a function of characteristic numbers in phase change problems: Stefan numbers and the ratio of thermal diffusivities of both phases. The results are compared with those given by a complete model integrating the physics of the coupling between heat transfer and crystallization kinetics. The solidification times computed from both models are very close, demonstrating the relevance of the simplified model. Finally, we also get a very good accuracy in calculating the total cooling time, from injection to ejection.Copyright © 2010 by ASME


On one hand lightweight sheet materials are characterized by high specific strength but on the other hand, they are limited in the design of sheet metal products. To extend the range of producible geometries, special forming processes at elevated temperatures have been developed. For describing the forming behavior at elevated temperatures or to design forming processes, the knowledge of relevant system parameters like flow stress, friction conditions and contact heat transmission coefficient is assumed. Additionally experimental results are presented to highlight the potential of sheet metal forming processes at elevated temperatures.


Brain metastases dramatically limit prognosis of lung cancer patients. Unlike systemic disease, brain metastases from lung cancer poorly respond to checkpoint-inhibition therapy. Targeting the immunosuppressive tumor-associated macrophages and microglia (TAM/M) and their receptor CSF1R may increase efficacy of checkpoint-inhibitors.

 Cranial windows were prepared in fully immunocompetent, transgenic CX3CR1GFP/wt-mice with green-fluorescent TAM/M. Intracranial injection of red-fluorescent Lewis Lung Carcinoma-cells was performed, and mice received one of the following three treatments: PD1-inhibition only (n = 8); PD1-inhibition combined with an anti-CSF1R-antibody (exhibiting limited blood-brain-barrier permeability under physiologic conditions, n = 8); or PD1-inhibition combined with a small molecular CSF1R-inhibitor (exhibiting high blood-brain-barrier permeability, n = 7). Tumor growth and TAM/M were followed by repetitive two-photon laser-scanning-microscopy over weeks.

 Following intracranial injection, metastases were detected in all three treatment groups within eight days. In mice receiving PD1-inhibition only, metastases showed exponential growth which was paralleled by intra- and peritumoral accumulation of TAM/M. Treatment with an anti-CSF1R-antibody resulted in significantly lower numbers of intratumoral TAM/M given increased tumoral blood-brain-barrier permeability, but did not substantially affect peritumoral TAM/M or TAM/M localized in the healthy contralateral hemisphere. In contrast, treatment with a small molecular CSF1R-inhibitor not only reduced the number of intratumoral TAM/M, but also of peritumoral and contralateral TAM/M. Compared to PD1-inhibition only, the addition of either an anti-CSF1R-antibody or a small molecular CSF1R-inhibitor resulted in decreased tumor growth (tumor size on day 12: 8.3 mm2 (PD1-inhibition only) versus 0.9 mm2 (PD1-inhibition + anti-CSF1R-antibody) versus 2.5 mm2 (PD1-inhibition + small molecular CSF1R-inhibitor)) (p = 0.01). The beneficial effects of the small molecular CSF1R-inhibitor in reducing tumor growth were similar to those of the anti-CSF1R-antibody.

 Targeting intratumoral TAM/M using CSF1-inhibition may increase the efficacy of checkpoint-inhibition therapy for cerebral lung cancer metastases. This approach warrants further evaluation in preclinical and clinical studies.


Modified zeolite with better nitrogen removal effect was used to prepare antibacterial adsorption materials for treating the secondary effluent of high-concentration coliform and ammonia nitrogen.Among Ag+,Zn2+ and Cu2+ ions,silver-supported antibacterial adsorption materials have the best antibacterial properties and are beneficial to nitrogen removal.The optimal preparation conditions are the following:AgNO3 concentration of 85mg·g-1,pH 6-7,preparation time of 120min,reaction temperature of 40℃,and reaction speed of 150r·min-1.After the optimization,the silver content in the prepared materials is 49.79mg·g-1.0.5g·L-1 of silver-supported antibacterial adsorption materials and 2g·L-1 of zeolite were applied to treat renewable water under the optimal conditions.The results show that the reaction time is 120min,the sterilizing rate is 98.87%,the removal rate of ammonia nitrogen is 66.54%,the mass concentration of residual nitrogen is 8.36mg·L-1,which achieve the water-quality indexes of the urban miscellaneous water.


Previous research has questioned the educational value of taking introductory courses in psychology. Study 1 confirmed the usual null to negative associations between taking introductory psychology and performance in a subsequent psychology course. Study 2 showed that, after controlling for IQ, there was actually a positive association between taking introductory psychology and performance on a psychology knowledge pretest, which, in turn, was positively associated with course performance. Partial correlation analyses suggested that the apparent disadvantages of introductory psychology are an artifact of self-selection. Specifically, although taking introductory psychology provides beneficial knowledge, the choice to take the course may indicate a maladaptive scholastic style—possibly antiscientific mindedness. We recommend advertising psychology courses more properly as science-oriented to avoid misleading potential students.


An efficient and versatile method was used for the diastereoselective synthesis of achiral and racemic spirohydantoins based on ketones 4, 5, 7 and 10.


The manufacturing technology of polymer optical waveguide called SPICA (stacked polymer optical IC/advanced) utilizing a unique replication process is presented. The performance of the single mode waveguide and the film type waveguide both at characteristic of a practical use level are discussed.


This paper set up a Matlab/Simulink model of ultrasonic motor,and then calculates out some samples about the rotational speed corresponding to the amplitude and frequency using this model.Finally,a BP neural network is set up based on these samples.It would provide a good foundation for the simulation and the research of the ultrasonic motor.


In this letter, we present the first attempt of active light-emitting diode (LED) indexes estimating for the generalized LED index modulation optical orthogonal frequency-division multiplexing (GLIM-OFDM) in visible light communication (VLC) system by using deep learning (DL). Instead of directly estimating the transmitted binary bit sequence with DL, the active LEDs at the transmitter are estimated to maintain acceptable complexity and improve the performance gain compared with those of previously proposed receivers. Particularly, a novel DL-based estimator termed index estimator-based deep neural network (IE-DNN) is proposed, which can employ three different DNN structures with fully connected layers (FCL) or convolution layers (CL) to recover the indexes of active LEDs in a GLIM-OFDM system. By using the received signal dataset generated in simulations, the IE-DNN is first trained offline to minimize the index error rate (IER); subsequently, the trained model is deployed for the active LED index estimation and signal demodulation of the GLIM-OFDM system. The simulation results show that the IE-DNN significantly improves the IER and bit error rate (BER) compared with those of conventional detectors with acceptable run time.


Self-oscillating mixers (SOMs) are an excellent choice for low-cost modern receiver architectures, because both the oscillating source and the mixer are combined in one single device. Moreover, subharmonic operation reduces LO frequency requirements and therefore provides a very good choice for millimeter-wave systems. In this paper, a fully-balanced SOM structure at high harmonics with high conversion gain is presented. The balanced structure provides inherent RF-LO isolation and suppression of harmonics and noise as well as it removes the input balun from the design, which permits integration into a monolithic microwave integrated circuit (MMIC)


Objective:To measure the smoking level among adolescent in Chengdu and make an intervention plan based on it.Method:Questionnaire investigation was used in 14 classes of middle school and 4 departments of 2 colleges.Results:The lifetime smoking rate of students in middle school was 32.9%,and 66.6% in college.The lifetime smoking rate of students in professional schools was higher than that of ordinary middle schools.Age of first smoking was 13.5 years old in middle schools,13.35 years old in male and 12.9 years old in female.Age of first smoking was 13.63 years old in college students,13.28 years old in male and 15.83 years old in female.Conclusion:Lifetime smoking rate among adolescent in Chengdu was higher than average level of Nation.In addition,age of first smoking among adolescent in Chengdu was early.Smoking control among youth should be improved in Chengdu.


Objective
To explore the underlying mechanism of why the suicide rate in females is higher than in males in China.

Methods
A county-wide suicide reporting system was established in Shaan′xi Province,to monitor suicidal behaviors,including attempted and completed suicide.From Jan.1,2009 to Dec.31,2010,all patients over 10 years of age treated in 14 general hospitals in the county for suicidal behaviors or accidental self-harm were identified.For each identified cases,information including name,sex,age,specific characteristics of the self-harm (method,time,etc.) and outcome,was recorded on a standardized form by an interviewer.Death certifications provided by the county′s Center of Diseases Control (CDC) were used to identify all completed suicides (International Classification of Diseases,ICD codes X60-X84) occurred from Jan.1,2009 to Dec.31,2010.

Results
In the 2 years investigation periods,406 patients with suicidal behaviors were identified,in which 366 were suicide attempters.In the same two years,57 person in this county died by suicide.The annual attempted suicide rate in the county was 67.1 per 100 000 (366/545 339),and the ratio of attempted suicide rate of females (96.1/100 000,254/264 177) to males (39.5/100 000,111/281 162) was 2.44.The annual suicide rate was 10.5 per 100 000 (57/545 339).The rate of serious suicidal behavior was 77.6/100 000 (423/545 339),and the ratio of rates of serious suicidal behavior of females (107.5/100 000,284/264 177) to males (49.1/100 000,138/281 162) was 2.19.The ratio of annual rate of attempters to completes was 6.42∶1.Among all the 423 cases who committed suicidal behaviors,19.6% male cases (27/138) and 10.6% female cases (30/284) were died by suicide.Sixty-seven percent (244/366) attempters committed suicidal behaviors with pesticide.

Conclusions
The rate of serious suicidal behaviors is 2.19-fold higher in females than in males,but the fatality of suicidal behaviors is 1.85-fold higher in males than in females,which contribute to a higher suicide rates in females than males in China.

Key words:
Suicide,attempted; Suicide reporting system; Ratio of rates of attempted to completed suicide; Pesticides


This paper analyzes and demonstrates the selection of main parameters and their characteristics for Laxiwa hydropower station turbines each with an installed capacity of 711MW,for the purpose of reference.


This essay reflects on the Supreme Court's recent decision in Salazar v. Buono, 130 S. Ct. 1803 (2010). The case involved a constitutional challenge, brought under the Establishment Clause, to a cross put up by private parties on government land in the Mojave National Preserve. This piece reviews the issues presented by the case (only some of which were addressed by the Supreme Court), and considers the future of the Establishment Clause in that light.


Frequency dependent inductance effects are becoming more evident for high-performance electronic packaging and IC design. This paper proposes a simple algorithm for generating upper and lower bounds on inductance, including frequency dependencies. These bounds can be applied for fast calculation of worst case inductance, or for quick screening to evaluate the impact of inductance over the frequency range of interest.


Day by day due to the increasing stress and depression, a huge percentage of people are affected by mental disorders and in certain cases, it is extreme and they need someone to monitor them always. It is observed to be a very tedious job in the current scenario. With the prominent use of sensors merged together and connected to Arduino, the device can monitor their activities throughout the day. Edge computing makes the classification of data easy. This paper deals with the system which detects human activity recognition and sends it to the remotely located caretakers. With the help of Docker technology this system can be implemented in any environment.


Using the mathematical model of a scene created earlier as a framework, a method is proposed for searching for zones of interest and a method of segmenting them in order to obtain projections of the objects found there and to measure their geometrical attributes. The starting information concerning the scene consists of a set of images of it. The results of computer experiments using both model scenes and pseudo-real scenes are presented.


Background: There are increasing reports of thromboembolic complications in patients with COVID-19 infection. According to a metaanalysis of 28,173 patients, the prevalence of venous thromboembolism (VTE) in hospitalized COVID-19 patients ranges from 7.9% to 22.7% based on the severity of COVID-19. Cancer and anti-cancer therapies are known risk factors for thrombosis. Another study based on registry data reported the overall prevalence of VTE in hospitalized COVID-19 patients with cancer to be 14.5%. Our study aimed to assess the prevalence of VTE in cancer patients diagnosed with COVID-19 as well as the association between VTE and cancer in the setting of COVID-19 infection in a large predominantly urban healthcare system. Methods: We utilized a cohort data query tool in the electronic medical record at University Medical Center in New Orleans, Louisiana to identify patients >17 years of age with a hospital or clinic visit in the LCMC Health system between March 1, 2020 and December 31, 2020 which were considered the base population for the study. Cancer patients were identified via the cancer registry tool. Patients with COVID-19 were identified using the abnormal COVID-19 PCR test result search field. An encounter diagnosis of deep venous thrombosis (DVT) or pulmonary embolism (PE) was used to identify patients with VTE. Odds ratios, p-values, and corresponding confidence intervals (CI) were calculated using 2x2 contingency tables. Results: In our database, we identified 3,807 patients with a diagnosis of COVID-19 and 9,560 with a cancer diagnosis. 158,812 patients had neither COVID-19 nor cancer. There were statistically significant greater odds of developing VTE in all subgroups compared: COVID-19 alone vs neither (OR 2.43), cancer alone vs neither (OR 3.8), and COVID-19 and cancer vs neither (OR 10.65). Conclusions: COVID-19 and cancer are both risk factors for VTE. Based on our study, appears that cancer has the greater effect on VTE compared with COVID-19 infection. Also, there is possibly a synergistic effect between COVID-19 and cancer, which further increases the likelihood of VTE. This study is a preliminary analysis. Further investigation is warranted in the form of either variable adjusted analysis of the same data, individual chart review, or a prospective study.


REPORT OF A CASE A healthy 4-year-old white boy presented with a 2.5-year history of recurrent stinging and burning discomfort of the dorsum of the hands, cheeks, nose, and chin following brief sun exposures. Within hours after sun exposure, his hands and face became painful and swollen. Edema gradually subsided over several days. Episodes typically occurred in late spring, summer, or early fall. At 16 months, the infant was noted to cry inconsolably on going outdoors. At age 3 years, the child resisted playing outdoors and preferred playing indoors near the air conditioner during the summer months. Despite his apparent cutaneous discomfort, he was never noted to have sunburns, blisters, hives, or "rashes." Family history was remarkable for a maternal uncle with similar photosensitivity and mild scarring of the face and dorsum of the hands. No personal or family history of urine or tooth discoloration was noted. Physical findings were


We report the first synthesis of (±)-3,4-dihydroxy-8,9-methylenedioxypterocarpan, a natural isoflavonoid that shows antitumoral activity. The key step involved the Heck reaction between the 7,8-dibenzyloxychromen and the organomercurial derived from sesamol, followed by debenzylation. The Heck adduct was also employed in the synthesis of the corresponding coumestan derivative, using DDQ as oxidant agent.


This research is to discuss the characteristics of the English teaching materials related with elementary English textbook. In 2011, we have used the 14 types of authorized elementary English textbooks for both 3rd grade and 4th grade by the partially revised elementary English curriculum in 2007 and 2008 consecutively. Standards difference between USA and Korea is very crucial point of material development. In USA socio-cultural aspects have been emphasized in view of multi-cultures and ethnography of immigrants societies. In Korea, these aspects have recently been introduced and they are on the very superficial stage of introducing foreign culture.


ABSTRACT
Pressured steam distribution pattern in a double leaf glass window model has been studied. The experiment was conducted with three different orifice designs; cone-up, streamlined, and funnel orifice with variations on its top diameter (D), bottom diameter (d) and orifice height (x). The result shows that steam distribution forming a truncated triangle pattern that spread up to the both side and lower part of the window model. Flow velocity measurement resulting that the system Reynolds number is higher than 4000.

Keywords: Steam distribution pattern, Orifice, Flow velocity


Abstract A female Argyrodes trigonum (Theridiidae) was observed feeding on a female Linyphia triangularis (Linyphiidae), a recently established European immigrant in Maine. Multiple observations of Argyrodes spiders inhabiting L. triangularis webs suggest that this invasive sheet-web weaver is not immune to web invasions, kleptoparasitism or predation by A. trigonum. The potential impacts of A. trigonum on the invasion dynamics of L. triangularis are unknown, but likely to be minimal.


Purpose of review The COVID-19 pandemic and associated restrictions have uniquely and disproportionately affected vulnerable populations. This review summarizes recent evidence on the relationship between psychiatric disorders, substance use disorders and COVID-19, highlighting acute and long-term risks, pharmacotherapy interactions and implications regarding appropriate and timely evidence-based treatment. Recent findings Evidence points to a complex relationship between psychiatric and substance use disorders and COVID-19. A range of risk factors associated with psychiatric and substance use disorders increases the risk of exposure to, and complications arising from, the COVID-19 virus. COVID-19 infection has been indicated as having acute and potential long-term impacts on both psychiatric and substance use disorders. Social disruption associated with restrictions imposed to curb transmission has also been identified as a risk factor for new onset of disorders and recurrence and exacerbation of existing conditions. Summary Early recognition and intervention are key to preventing chronic disability associated with psychiatric disorders, substance use disorders, and their co-occurrence. It is critical that those most in need of services do not fall through the cracks of our healthcare systems. The pandemic has fast tracked the opportunity for widespread implementation of digital health interventions but ensuring these are accessible and available to all, including our most vulnerable, will be a critical task for our future health and social ecosystems.


In Southern California, the Pacific‐North America relative plate motion is accommodated by the complex southern San Andreas Fault system that includes many young faults (<2 Ma). The initiation of these young faults and their impact on strain partitioning and fault slip rates are important for understanding the evolution of this plate boundary zone and assessing earthquake hazard in Southern California. Using a three‐dimensional viscoelastoplastic finite element model, we have investigated how this plate boundary fault system has evolved to accommodate the relative plate motion in Southern California. Our results show that when the plate boundary faults are not optimally configured to accommodate the relative plate motion, strain is localized in places where new faults would initiate to improve the mechanical efficiency of the fault system. In particular, the Eastern California Shear Zone, the San Jacinto Fault, the Elsinore Fault, and the offshore dextral faults all developed in places of highly localized strain. These younger faults compensate for the reduced fault slip on the San Andreas Fault proper because of the Big Bend, a major restraining bend. The evolution of the fault system changes the apportionment of fault slip rates over time, which may explain some of the slip rate discrepancy between geological and geodetic measurements in Southern California. For the present fault configuration, our model predicts localized strain in western Transverse Ranges and along the dextral faults across the Mojave Desert, where numerous damaging earthquakes occurred in recent years.


This article introduces a process to fabricate zinc oxide (ZnO) films through combining sol preparation and electrophoretic deposition (EPD). The experimental results have proved that the EPD process is a powerful route to fabricate ZnO films with desire thickness from stable colloidal suspension under a direct current (DC) electric field. In this method, ZnO sol is prepared by dissolving zinc acetate dehydrate (ZAD) as the main precursor and diethanolamine (DEA) as the additive in various solvents such as methanol (MeOH), ethanol (EtOH), and 2-proponal (2-PrOH). The deposition was performed under a constant voltage of 30 V for 2 min. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and diffuse reflectance spectroscopy (DRS) were used to characterize ZnO films. XRD pattern of the ZnO film prepared by MeOH shows the highest degree of preferential orientation and this is mainly attributed to the higher dielectric constant of the MeOH which results in higher current density in electrophoretic dep...


Abstract-A woman dial painter born in 1930 was exposed to 226Ra intake from October 1946 to October 1963 and to %r intake from May 1956 to May 1959. Her husband, born in 1929, was exposed to a26Ra from August 1952 to October 1963 and to YSr from May 1956 to May 1959. Total body counting during the interval 1963 to 1971 indicated that the effective retention half-times were about 3200 days for wSr and 5500 days for 2z6Ra in the woman, while corresponding values in the man were about 3300 days for 9OSr and 2700 days for z26Ra.


We propose a new, compact XRF spectrometer conceived for the determination of the thickness of a coating deposited on a substrate. The analysis technique is based on the detection, at different angles of observation, of the fluorescence emitted by the substrate and absorbed through the coating. With respect to other methods, the measurement is independent of the XRF analysis of the coating, which need not even be fluorescent. Moreover, no calibration of the instrument with standard samples is required. A key feature of the proposed spectrometer is represented by the use of a Silicon Drift Detector (SDD) for the first time in this kind of measurement. The SDD is characterized by a very low output capacitance (of the order of 0.1 pF), independent of the active area of the device, which allows one to achieve a lower electronic noise with respect to a conventional silicon diode of equivalent area and thickness. Based on a Peltier-cooled SDD, a compact spectrometer, characterized by an energy resolution of about 155 eV FWHM at 6 keV (at about −10°C), was realized. The analysis technique and the spectrometer compactness make this instrument suitable for on-line, non-destructive quality control in the semiconductor and mechanical industries. In this paper the measurement technique is described and the first experimental results obtained on samples composed of a substrate coated with a layer of different thickness are presented. Copyright © 2002 John Wiley & Sons, Ltd.


This article deals with the role of the family in the proper diagnosis of ADHD, from the process involved in the theme, our general objective is: To analyze and discuss the role of the family in the learning process of the person with ADHD, to discuss the educational needs experienced during their teaching-learning process. Moving on to working on the specific objectives: Identifying the family's role in the diagnosis and necessary interventions; This study adopts the methodology of literature and documentary review on the subject, whose data are in the qualitative perspective; Arguing and confronting the data, supported by the experiences of authors who base the Attention Deficit/Hyperactivity Disorder (ADHD) as a neurobiological disorder that has the characteristic of inattention, restlessness, impulsivity and hyperactivity. Since the subjects are both children and adults, it is independent of gender, age and academic background. Symptoms appear mainly in situations that require greater attention and the performance of repetitive tasks. This article is justified by the importance of the family for the development of potentialities and improvement of the personal and social quality of life of the person diagnosed with ADHD, starting to understand its impacts and understand it.


Abstract : The events of September 11, 2001 prompted a fresh look at the impact of human activity on the global environment. Environmental issues are increasingly at the forefront of US national security strategy. Environmental, industry, and security form a complex public policy "crossroads" that will require significant attention in the future. This paper examines worldwide environmental challenges and the US Environmental Industry. Policy recommendations are provided, with emphasis on maintaining biodiversity, sustaining the use of limited natural resources, and coping more effectively and aggressively with global climate change.


Graphene is the two-dimensional building block for carbon allotropes of every other dimensionality. We report the terahertz spectrum of Non-uniform graphene films based femtosecond probing with more than 6 THz spectral coverage and the 1 GHz resolution using high-speed asynchronous optical sampling, and it operates at 2 kHz scan rate without a mechanical delay stage. The overall waveform creates shock and the oscillation amplitude reached 0.37E-4 mV, main-peaks time delay is 151.83fs between graphene and substrate, frequency spectrum oscillatory fades at 2.8 THz and appeared obvious absorption peak.


The German drug industry has appealed to the German government to reform its drug pricing law, saying that it is denying patients access to innovative drugs available in other European countries.

The appeal was made by the Federal Association of the German Pharmaceutical Industry (BPI) at a press conference in Berlin to mark the fifth anniversary of the approval of the law, which is widely known in Germany as AMNOG (ArzneiMittelmarkt-NeuOrdnungsGesetz; pharmaceuticals market reorganisation act).

The main goal of AMNOG was to slow the rise in drug prices, but five years ago supporters of the law also said that it would encourage innovation, because it allows drug firms to charge higher prices for new drugs with proven "added benefits" compared with drugs already on the market.

Martin Zentgraf, chairman of BPI, said at a …


The step-size in well-known variable step-size least mean square (VSSLMS) is updated as μn+1 = αμn + γen2 with , γ > 0, and μn+1 is set to μmin or μmax when it falls below or above these lower and upper bounds, respectively. It provides fast convergence at early stages of adaptation while ensuring small steady-state misalignment. This paper considers the steady-state performance of the VSSLMS in non-Gaussian noise environments. The contribution of the paper to the VSSLMS is threefold; (1) when γ ≪ 1 - α, the VSSLMS has low steady-state misalignment. (2) when α ≪ 1, the VSSLMS achieves different steady-state misalignments for different noise distributions. (3) In theory, there are different optimal values α for different noise distributions, i.e., 0.17 (Gaussian distribution), 0.21 (Student distribution), 0.38 (Laplace distribution), 0 (Binary and Uniform distributions). Analytical results are compared with simulations and are shown to agree well.


An interview study on mathematical argumentation (in a broad sense) was conducted with teachers of upper-secondary calculus classrooms. This paper describes the study's methods and its results. By using qualitative text analysis, four major categories were created to depict the current state of mathematical argumentation in calculus classrooms. Two dominant problem areas were revealed: Students' language difficulties and the heterogeneity of students. To address these problems, a learning environment was designed and evaluated in a follow-up study.


A new way of demonstrating Sino-Tibetan phylum genealogical relationships — historical typology is presented in the paper.Some phenomenon about original remains and common innovations of Sino-Tibetan phylum is discussed with examples,and some discussion is made to them.


The Australian Government recently established a new national regulatory and quality agency for higher education, the Tertiary Education Quality and Standards Agency (TEQSA). TEQSA will register providers, carry out evaluations of standards and performance, protect and assure the quality of international education and streamline current regulatory arrangements. As a precursor to TEQSA, the Australian Teaching and Learning Council has been commissioned to work with clusters of discipline communities to begin to specify how threshold learning outcomes particular to each discipline might be used as a basis for academic standards. This paper details the work of the Building and Construction discipline. A draft set of six TLOs have been developed to benchmark the graduate outcomes from Bachelor-level study in building and construction management in Australia. The draft TLOs have broad consensus agreement across the building and construction discipline and are evidence-based. It remains for the TLOs to be made more specific through further notes and examples, and for the representation of industry, students and recent graduates in the process to be improved.


How to understand Hegel's metaphysics or his Logik is essential to the comprehension of his philosophy.Because of our meager understanding of Hegelian metaphysics,the study of Hegel in China is not prosperous enough.Since the 1930s the Chinese scholars have been claiming that there was an inner connection between Hegelian ontology and theology and that Hegelian ontology was a "speculative creation." One has to get clear about some of the basic concepts of Hegel's philosophy,either from the metaphysical or the epistemological prespective.Hegel's concept of Geist has intersubjective character from the beginning.His metaphysics and ontology are never the same as those before Kant.Hegel's concept of Gott has its own meaning.If we understand it from theology or absolute idealism,we will fail to obtain a proper comprehension of Hegel's philosophy.


We present a novel receiver-based interference reduction mechanism for Vehicular Visible Light Communication (V-VLC). V-VLC, in combination with Radio Frequency (RF)-communication, is a technology that is promising to enable a reliable communication link for a number of Intelligent Transportation Systems (ITS) applications such as cooperative driving. Both technologies complement each other to overcome technology-dependent limitations. Particularly, V-VLC is drawing attention as it is able to provide rather high capacity links. Nevertheless, it was observed that V-VLC suffers from interference caused by ambient light as well as modulated light sources, for instance LED signage. To overcome this barrier, we propose a system that makes use of the Line of Sight (LOS)-characteristic and imaging optics. More precisely, we are using a spatial light modulator in the form of a Liquid Crystal (LC)-panel to spatially filter interference and ambient light, thereby reducing interference to a minimum. We built and tested a photodiode-based receiver for V-VLC and, validated by simulations and measurements, we demonstrate the capability of the system.


Abstract : First, a brief overview is provided of the current state of USARIEM algorithms for predicting the physiologic strain and weather related casualty rates associated with exposure to hot or cold environments. Next, a prototype software program is described that demonstrates the technical feasibility of consolidating numeric models for altitude, cold, and heat strain with operationally oriented handbooks for environmental physiology and medicine. This software program is a unified and dynamic environmental medicine and physiology computer-based tool of potential use for military medical personnel in predeployment analysis, planning, and training. The program's altitude module utilizes a simplified model of hypoxic strain. The altitude model does not yet include closed-loop feedback physiologic mechanisms or altitude illness prediction. These are areas requiring further altitude modeling efforts. The cold strain module's data structures and input-output interfaces were designed for USARIEM's lumped-parameter cold digit model. The heat strain module employs the well-established USARIEM Heat Strain Algorithm with an expanded interface that provides improved flexibility with regard to data entry and display modes. On-line medical handbooks provide narrative, tables, and reference lists. These could be enhanced with interactive tutorials for use in medical training situations.


This article explores the nexus between the Zimbabwean Shona concept of "ngozi" (avenging spirit), Zimbabwean transnational migration, and restorative justice in Brian Chikwava's Harare North. In Shona cosmology, once "ngozi" is committed, it has to be recompensed in order for restorative justice to occur between individuals, families, and the community in general. However, failure to appease "ngozi" results in inexplicable misfortunes such as sicknesses or eventual death or deaths of the person or persons who would have committed the "ngozi." Thus, engaging in transnational migration as a way of escaping "ngozi" is futile as the only solution to "ngozi" is to recompense the victim and his or her family and ensure that restorative justice takes place between individuals, families, and society in general.


The sterol profile of three Algerian virgin olive oils produced from Guasto, Blanquette and Rougette cultivar's, varieties grown in the East of the country, was established by gas chromatography using a flame ionization detector and coupled to mass spectrometry. Four sterol compounds were identified and characterized in the three oils which are, sitosterol always predominant (43-66%), delta 5-avenasterol (8-13%), stigmasterol (≤ 1,5%) and campesterol (1-2%); one methyl sterol (4-methylsterol) : citrostadienol (4-7%) and two triterpenic alcohols : 24-methylene cycloartanol (10-33%) and cycloartenol (3-13%). These results vary according to campany and variety. Our study shows that most of these compounds were affected by climatic conditions especially during the campanies 2004-2005 and 2005-2006. The amounts of the four identified sterols are in agreement with the European regulation (Reg. (EEC) n° 2568/91, appendix 1).


WI-FI is currently a popular wireless LAN technology, with access to high speed, large coverage area and so on. WI-FI has its flexibility and mobility, more and more attention, showing great prospects. This article describes the characteristics and advantages of WI-FI technology, combined with the actual situation of a WI-FI based wireless sensor technology and monitoring system for the implementation of the mine ventilation plan, and the program specific application in the monitoring system has been described, the program has proved flexible, simple wiring, has certain application value.


Quality has always been one of the most important aspects in manufacturing as well as service industry. In the competitive world each and every organization has to pay utmost attention to quality for its survival. In this paper quality prospective of An Indian cement manufacturing firm are being identified via the quality control techniques which it use in manufacturing. This cement manufacture uses one of the most advanced cement producers in India. But before analyzing the manufacturing process from the quality point of view, the fundamentals of Quality must be evaluated correctly. This article give an over view of quality and its definitions, quality control and quality inspection along with the quality tools used to control and inspect quality in the cement manufacturing firm.


Wilbur Schramm describes two kinds of rewards people receive from reading the news. The first is the immediate reward which provides pleasure or a vicarious experience for the reader. This category would consist of ''news of crime and corruption, accidents and disaster, sports and recreation, social events and human interest/'' The other is a delayed reward, something Schramm characterizes as closer to "reality," which consists of "news of public affairs, economic matters, social problems, science, education and health."^ The delayed reward helps the reader ""avoid trouble by being informed/' even if it helps him just to stay dry because he read a forecast predicting rain.-̂ Walter Lippmann has said that the American society has been shaken because it was unprepared for change, not well enough prepared to cope with growing government, economy and technology.** Lippmann blames society's unpreparedness on the inability of the press to socialize and educate.^


. The purpose of the study is to propose new technological methods to optimize laparoscopic treatment of surgical diseases of the abdominal cavity. The study material included 6 patients with a perforated duodenal ulcer. All patients had reactive stage of peritonitis. All patients were of working age. The examination of the patients included a standard for patients who are planned for laparoscopic surgery, a complete blood count and urine test, a biochemical blood test, an ultrasound scan, etc. The diagnosis was confirmed by X-ray examination. Three patients used a modified needle for the imposition of intracorporal manual suture. Needle modeling was performed intraoperatively. A bend was created in the body of the needle, which made it possible to avoid its rotation in the needle holder. Another three patients with perforated duodenal ulcer applied the method of extracorporeal node formation. Intraoperative complications in patients were not observed. The postoperative period in all patients proceeded smoothly, without early and late postoperative complications. During the analysis, it was found that the time of surgical treatment in the application of the developed techniques was reduced by 8.9 ± 2.4 minutes. The proposed technological innovations have significantly simplified the work of the abdominal surgeon and reduced the time of surgical treatment, which may affect the degree of surgical aggression.


THE following case of rapidly progressive paralysis closely simulating acute polyneuritis (the Guillain-Barr. syndrome) is reported because it occurred four weeks after the administration of oral poliomyelitis vaccine and Poliovirus Type III was isolated from the stool on the first day of illness. This patient has shown encouraging improvement but the degree of recovery is, as yet, in doubt. The possible relationship to the poliomyelitis immunization procedure is discussed.


In 2008, the United States' electrical generating capacity peaked at 1,000,000 Megawatts, the highest values on record. Demand has steadily increased over time, with future projections showing a continued increase. Electricity demand is a value generally expressed in kilowatts (kW) and is determined by the sum of all electrical power loads at a given moment. For some producers, demand costs comprise up to 60% of their monthly electric bill. Energy demand is a topic many agricultural producers know little about and often many agricultural business owners do not understand how demand costs affect their bottom line. This study provides information about energy demand and how demand values are derived. The study also explains the costs associated with high demand, and ultimately how these costs can be curbed. The study investigates how demand controllers and operation best practices at farms and grain facilities can be incorporated to reduce demand costs. This study found that for a grain drying system in Wisconsin, implementing a demand management strategy can lower the farm's energy bill by as much as $600 per month and have a return on investment of 2.1 years.


In 1957 Stanford University proposed to the Federal government the construction of a two‐mile‐long linear electron accelerator. Originally called the "Monster," the machine was to be very much larger than any that had been previously carried out under the aegis of a single university. It was also an electron rather than a proton machine, and thus not in the mainstream of particle accelerators at the time. However, it seemed clear that there was useful physics to be learned from electron scattering, and the proposal for "Project M" was well received. Renamed the Stanford Linear Accelerator Center a few years later, the proposal was accepted and funded. Ground was broken in 1962, and the accelerator produced its first beam in 1966.


Both throt~~OoenzOolic and Izenlorrhagic tendencies have been reported in P thalasseruin. Platelet Junction tests tnight help elucidate its role in these events. In vitro platelet aggregation to ADP, collagen and ristocetin togetlter with platelet count rasios ( F / E) were measured in 30 /3 thalassetnia adults. They were cornpared to 20 matched controls. Results showed defective platelet aggregation in all patients. INTRODUCTION & AIM OF THE WORK 'I'brombo embolic ~vents, which iue associated with significant morobidity and mortality occur in beta thalassemic patients (Micheali et al., 1992). These include recurrent and transient ischemic cerebral manifestations and strokes (Paolini, et al., 1983). Also a high frequency of thrombotic lesions in thc pulmorlary artcries has been observed at autopsy (Sonakul et al., 1980). On the other hand, ElQor et. a'., (1989) have noticed a significant decrease in platelet aggregation responses to various agonists. This may explain the rare hemorrhagic tendency in this disease but, as noted by them, cannot acount for the increased risk of thrombo embolism. The airn of his work is to study and compare in vivo and in vitro platelet functions in beta thalassemia major patients. SUBJECTS AND METHODS 'Thirty adult beta thalasse~nia major Consistillg of 16 non splenectomized patients were included. They comprised cases. 17 males (and 13 females wilt] age rallgc All patients wcre chosen at least 6 " l2 25* were sub-divided lllollths after their last hemolytic crisis and group A : 2 weeks after their last blood transfusion. (lonsisting of 14 splcncctomizecl cases They were all undcr regular dcsferroxa:u~d group B : mine therapy for Inore than 6 months. 38 . ,,,,,,,.Alas Al-Zayat, O~nur Khashab et id., ................................................ Twenty healthy age matched controls were chosen for comparison. None of the included subjccts recieved aspirin or any other platelet function inhibitor at least 7 days before testing. Full history and clinical examination were undertaken in every subject with stress on tiirombo embolic or bleeding manifestations. Investigations : Urine and stool analysis, liver and renal functions, complete blood count with direct platelet count, serum iron and total iron binding capacity (TIBC) together with hemoglobin electrophoresis were performed lo all cases. An ECG and chest x-rays were also routinely performed. Clotting time, prothrombin time (PT), Partial ffirombo plastin time (PTT) and fibrinogen were done. In vitro platelet aggregation studies were performed in all groups in response to : ADP (N : 65 loo), collagen (N : 75 loo), Ristocetin (N : 85 100) (Bauer, 1982). In vivo platelet aggregation studies were also performed in all groups by calculation of platelet count ratios according to Wu and Hoak (1974). This method compares platelet count fourid in a blood sample added to buffered E.D.TA. / formalin mixture, to another samplc added to E.D.T.A. solution alone after centrifugation. Platelet count in the sample added to E.D.T.A. 1 formalin ~nixture would be lower than that in Ule samplc added to E.D.T.A. alone if platelet aggregates were present. This is because platelet aggregates, when found, are fixed and centrifuged down in the E.D.T.A. / formalin mixture but are broken down in E.D.T.A. alone. Platelet count ratio (FE) are calculated as follows : l'latelet aggregate ratio = (F 1 E). (F) Platelet count in E.D.T.A. / formalin platelet rich plasma (E) Platelet count in E.D.T.A. Normally, the ratio would be close to one. If platelet aggregates are present, the ratio would be much less Uian one (Wu and I loak, 1974). RESULTS Clinically, all patients showed the was elevated in all paticnts with a mean of characteristic facial changes of thalassem3.6 mg/dl f 1.4. ic patients with growth retradation and Serum iron was significantly higher in diffMnt degYees he~flfos~lenomegal~. patients ( 1 93.7 "g / dl 5 1.7) ban in conOne patieril showed bilateral loss of trols (1 14.7 ug / dl f 15.6) and Hb level terminal phalanges of both ring and little was signil'icantly lower (7.5 gm 94~ * 1.3) fingers. Another complained of mild rewith platelet count within the normal range current epistaxis. in all groups i~lcluding the spleneclornized seen in table ( I ) , serum bilirubill group A. HbF was 45.5% + 17.7 among patients. ,;;;;;;;;;;;;;;;;;;;;;;;;;;;;;; Platelet Aggregation . . . . <;<; ; ; i / Groups A + B showed a mean P.T. of 77.4 %. Bleeding time (BT) was prolonged in 3 patients, only one of whom suffered of mild recurrent epistaxis. Clotting time, PIT and fibrinogen were within normal. In vitro platelet aggregation studies showed significant reduction in platelet aggregation to ADP in groups A (29%) and B (21.6%) versus controls (91.4%) (see figure 1). In all in vitro aggregation studies there was no significant difference between splenectomized and non splenectomized patients. In vivo platelet function studies showed a significant reduction in platelet count ratio (FIE) in both groups A (0.5) and B (0.6) versus control group (0.9). There was no statistical significance betwecn splenectolnizd and non splenecLomized patients (see figure 2). A similar significant reduction in agA positivc correlation was found in all gregation to collagen in groups A (18-6%) patients between iron level and platelet an? B (15.6%) versus contfols (88%) was aggregatio~l with ADP, collagen and risali6 noted (se figure 1). Platelet aggregatocetin and iron level. However no such tion to ristocetin was dso significantly rewas found with platelet count duced in group A (26%) and B (22.5%) ratio. versus co~ltrols (89%) (See figure 1). DISCUSSION Platelets play a prunoridial role in hemostasis. Variation in platelet function is . hcld to be an important factor in arterial thrombosis (O'Brien et al., 1974). Platelet functions in beta thalassemia was a point of controversy as both thrombotic and hemorrhagic events have been reported (Eldor ct al., 1989). Platelet aggregation using an aggregometer was reported by Dacie and Lewis (1985) to be the best single in vitro test of platelet function. Eldor et al., (1989) noticed a significant d e ~ ~ e b c in platelet aggregation responses to various agonists. Platelet aggregation defccts had also been previously noted by Hussierl et al., (1979). In this work, collagen and rcstocetin were used a exanples of strong agonists for in vitro platelet aggregation, while ADP was used as an examplc of weak agonists. In vivo platelet activation was mcas ured by the platelet count ratio technique which detects circulating platelet aggregates. In all our 30 thalassemic patients clinical findings were identical to lhose reported in Egyptians (Sabry, 1973, and Mokhtar et al., 1983). Blood picture among patients showed marked anisocytosis and poikilocytosis with target cells and normoblasts. Averagc hemoglobin was 7.5 gm + 1.3 similar to other reports (Ozsolu et al., 1973 and Mokhtar et al.. 1985). Morphological red cell changes was more evident in splencctomized patients (group A). This was also observed by Polliack et al., 1974 and Rachmilewitz et al., (1985). Table (1) : mean value (* SD) of all patients group


In a two countries model, I theoretically derive a partial equilibrium relation for home and foreign investment stocks by multiproduct multinational firms, each located separately in one of the two countries. I then address the existence of a Market Share Effect, that is the more than proportional growth in the stock of investment following an initial rise in the market share of a multinational firm. The explanation is that this rise originates a reciprocal adjustment in the worldwide market shares of the two multinationals, eventually feeding back in foreign investment stocks. In the empirical sections, working on data on Japan and US, I present some stylized evidence and estimate the theoretical predictions of the model. The empirical evidence provides only partial support to the theory.


The article examines the evolutionary stages of China's foreign policy concept and the features of the nature of international relations in the main geopolitical directions of China's foreign policy activity. The reasons that contribute to unification and successful cooperation between the countries and, on the contrary, the reasons that have a negative impact on mutual relations and serve as a source of discord are investigated. It outlines and describes key changes in China's foreign policy as it strengthens its comprehensive national power. The article also outlines the differences of Chinese school of geopolitics, which has its own historical, cultural and philosophical roots. It provides a brief overview of China's policy on " strategic boundaries" and "living space" and its possible implications for Kazakhstan and Central Asia as a whole.


Abstract — Solar energy is renewable souce of energy is used in various application like solar water heater, solar cooker, solar lamp etc. Here we have discuss about recently developed model of pyra box cooker which have not sufficient for frying purpose .so as to improve the Thermal performance of pyra box cooker we have used Linear Fresnel lens & Mirror Reflecor.For this we have taken two tests under two different conditions: cooker without Fresnel lens & mirror reflector and cooker with Fresnel lens & Mirror reflector.Temperature measurements were taken at intervals of 5 minutes.Results of the thermal performance tests show respective stagnation absorber plate temperatures , First/Second Figures of Merit are  obtained as per BIS .The total heating times of 1.2 Kg of water when Fresnel lens was removed and when exposed to solar radiation are find out during water heating test. Thus, the overall thermal performance of the cooker when Fresnel lens & mirror reflector is exposed to solar radiation is superior to its thermal performance when Fresnel lens & mirror reflector removed from cooker. This superiority is manifested in improved values of the First and Second Figures of Merit, cooking power


An automatic synthesis equipment for 18FDG by micro-computer control was manufactured for trial. In order to perfectly prevent a mistaken action, new methods were introduced in the hardwires and the softwares. Moreover, if a part of the control becomes out of order, only that action is changed over to manual operation immediately, and it was made so that the synthesis can be continued. By this means, the synthesis became feasible without fail.


Abstract In this experiment a polycrystalline Ag surface was bombarded by 0.8–3.2 keV Na+ ions. The angle between the incident beam and the surface was tixed at 45°. The energy spectra of scattered Na+ ions and secondary electrons were simultaneously measured. A shift to the lower energies of the Na+ → Na "single" scattering peak as well as L2.3 MM Na Auger electron emission were observed. These effects are discussed and correlated.


A feather degrading fungi was newly isolated from marine sponges collected from Kulasekarapattinam, Tuticori district, Tamil Nadu using agar mineral medium containing soluble keratin as a substrate and it was identified by its morphological features as Scopulariopsis brevicaulis. The selected growth medium contained feather meal as a sole source of carbon and nitrogen at pH 7.5 and temperature at 28±2 0 C. Purification was carried through ammonium sulfate precipitation and chromatography via Sephadex G- 100 column using with soluble keratin as a substrate, 10.0-fold purification with a yield of 22.8% was obtained. The partially purified keratinase has a molecular mass of 28±0.5 kDa, optimum pH in the neutral region 7 to 7.5 and optimum temperature of 50 0 C.The keratinases produced by the fungi could be useful in decomposition of keratin-wastes and could find applications in leather, pharmaceutical and cosmetics industries as well.


The recent New York State Geologic Map (Lower Hudson Sheet, 1961) has placed all metamorphic lithologies to the east of a central marble belt in Bronx Borough, along the Webster Avenue Valley (FIGURE l), under the designated unit ux-sg," gneisses and schists undivided. However, the older references, i.e., U.S. Geological Atlas, Folio 83, Geology of New York City (Merrill et al . , 1902), and Berkey's Geologic Mup of New Y o d City (1924), considered these easterly units as part of the Manhattan formation (FIGURE 2). Outcroppings of these lithologies constitute the Botanical Garden area. Kurt E. Lowe of the City College (1963) has stated that the units of the northern-most part of the Gardenarea (the "gorge" of the Bronx River) closely resemble lithologies of the Manhattan formation; however, the southern units are, at best, "atypical" Manhattan lithologies. He further indicated that the southern units a r e so gneissic, so highly contrasted, and so unlike the type lithology of the Manhattan formation, that they most likely constitute another phase of the Fordham gneiss. The author studied the geology of the Botanical Garden area in 1959-1960 and then suggested that theseunits were part of the Manhattan formation, Units constituting the northern and southern portions of the Garden were walked out and found to make up a single metamorphic unit (FIGURE 3). Therefore, the Botanical Garden area occupies a critical position in the interpretation of the stratigraphy of New York City.


ABSTRACT We measured the electric conductivity of large (25 × 50 mm) graphene films as a function of number of layers in the range of 1–20 layers. We also calculated the energy gap for such samples using density function theory. Our results showed a conductivity slightly above that of ITO for monolayer graphene and an exponential decrease as the number of graphene layers increased. Both experimental and simulation results showed a convergence of graphene into graphite at as little as 18–20 layers.


This work describes a fast, simple, sensitive, and low-cost method for the
identification of resveratrol in different brands and varieties of red wines.

 It was developed based on a comparison of the UV-VIS spectra of the samples and samples
enriched with different concentrations of the trans-resveratrol standard. The spectra were analyzed
by chemometric principal component analysis (PCA) and multivariate calibration.

 The PCA data indicated that only 4 main components made possible group samples based
on the grape variety characteristics and/or production region.

From the construction of partial least squares (PLS) and multiple linear regression
(RLM) models, it was possible to predict the sample trans-resveratrol content with that sample
showing similarities between the groups observed in the PCA and the samples used in the model
constructions. The predicted trans-resveratrol present in these samples ranged from 0.29 to 23.3 mg L-1.
This multivariate method suggested a good predictive capacity of determination of resveratrol concentrations
in commercial red wines.


Taking the listed IT family and non- family enterprises in Shanghai and Shenzhen A shares as research samples,based on the 2009- 2013 panel data,this paper conducts a comparative study on the relationship among open innovation,dynamic technological innovation capability and operating performance between family firms and non- family enterprises. The results show that: compared with non- family firms,open innovation of family business plays a weaker role both in the input and the output capability of technological innovation,while it has a stronger promoting effect on transformation ability of technological innovation; open innovation will contribute to enterprises' s market performance,especially the market performance of family firms,but will not substantially improve the financial performance of the companies; the effect of input capability of technological innovation contributing to business performance in family firms is considerably superior to that of non- family ones,while the promoting effect of the output capability and the transformation ability of technological innovation to operating performance is significantly inferior; constrained by social emotional wealth in the operational objective function,family firms' transformation ability of technological innovation has a weaker promoting effect on financial performance when compared with non- family competitors.


- A Decision Support Systems (DSS) is a particular type of computerized information system that support business and organizational decision making activities. on the other hand, Data Mining (DM) expand the potentials for decision support by finding styles and connections hidden in the data and in this way enabling an inductive way to deal with data analysis. Data is analyzed through a mechanized process, known as Knowledge Discovery in data mining techniques. Data mining can be characterized as a process of browsing and analysis for large amounts of data with a particular focus on discovering significantly important patterns and rules. Data mining helps discovering knowledge from raw, not equipped data. Utilizing data mining techniques permits extracting knowledge from data mart, data warehouse and, specifically cases, even from operational databases. In this paper a methodology is introduced to integrate the DSS with DM for loans to the Real Estate developments fund (REDF) Customers. It causes to cooperative interaction of DSS, through getting more options to analysis, utilizing expert's data, and improving assessment process. So I will talk about the function of data mining to simplify decision support, the utilization of data mining methods in decision support systems, talking about applied approaches and present a data mining decision support system called DMDSS – (Data Mining Decision Support System). We also present some obtained results and plans for future development.


The unstretched, alpha -form polyvinylidene fluoride (PVDF) film shows the four TSC peaks, P1, P2, P3 and P4 in ascending order of temperature. The P1 and P2 peaks are due to the dipolar depolarisations associated with the alpha a and alpha c relaxations, respectively. The TSC spectrum in each film composing a three-layer specimen gave evidence for the P3 and P4 peaks originating from space charge near the anode. Besides, the use of a blocking PP electrode revealed the contribution of hole injection to the current in PVDF under the application of high field and also the contribution of injected positive space charge to the P3 and P4 peaks.


In this study, we examine the innovation effects of technology intermediaries on different types of innovation and the roles they play in different sectors at a regional level. Using a panel of data for 31 Chinese provinces during the period 2003–2011, we empirically test the relationship between numbers of technology intermediaries and regional innovation performance. The results show that technology intermediaries make positive contributions to regional product-related innovation and have more positive effects on innovation performance in high-tech industries, improving both knowledge-related innovation and product-related innovation in high-tech sectors. These findings could extend our understanding on the innovation effects of intermediary institutions at the regional level. The research also suggests clearer and more specific goals for policies favourable to intermediary institutions.


Background In armed conflict, injuries commonly affect the extremities and contamination with foreign material often increases the risk of infection. The use of negative-pressure wound therapy has been described in the treatment of acute conflict-related wounds, but reports are retrospective and with limited follow-up. Objective The objective of this study is to investigate the effectiveness and safety of negative-pressure wound therapy use in the treatment of patients with conflict-related extremity wounds. Methods This is a multisite, superiority, pragmatic randomized controlled trial. We are considering for inclusion patients 18 years of age and older who are presenting with a conflict-related extremity wound within 72 hours after injury. Patients are block randomly assigned to either negative-pressure wound therapy or standard treatment in a 1:1 ratio. The primary end point is wound closure by day 5. Secondary end points include length of stay, wound infection, sepsis, wound complications, death, and health-related quality of life. We will explore economic outcomes, including direct health care costs and cost effectiveness, in a substudy. Data are collected at baseline and at each dressing change, and participants are followed for up to 3 months. We will base the primary statistical analysis on intention-to-treat. Results The trial is ongoing. Patient enrollment started in June 2015. We expect to publish findings from the trial by the end of 2019. Conclusions To the best of our knowledge, there has been no randomized trial of negative-pressure wound therapy in this context. We expect that our findings will increase the knowledge to establish best-treatment strategies. Trial Registration ClinicalTrials.gov NCT02444598; http://clinicaltrials.gov/ct2/show/NCT02444598 (Archived by WebCite at http://www.webcitation.org/72hjI2XNX) International Registered Report Identifier (IRRID) DERR1-10.2196/12334


This study of the histocial development of St. Jerome's follows a methodology aimed at discovering ali those aspects which allow us to determine the limits of this space, as well as the guidelines for public protective action, that is the "ground rules" for what is formally recognized in law as the protection of our historical heritage. We therefore examine the historical development of the surroundings of the monastery and determine the various contents (and forms) which constitute the relationship between the building and its environment. Jncluded in this overview, indeed, occupying an imponant place in it, is an analysis ofthe effects ofthe carrying out ofthe Spacial Plan for the Interior Reform of St. Joreme's Monastery. Finally the examination of the interrelationship between the monastery and the town leads us to define clearly the area affected by the monastery, and to take up a definite posture in our demand for cenain courses of action to be pursued.


As for the weak theoretical foundation of the Particle Swarm Optimization(PSO) algorithm and its analysis of the nature of the problem having not yet formed system,a new quantum model was established,which was based on quantum mechanics from the microscopic point of view.This model defined the search process as quantum state transition that in infinitely deep potential well.Through the model,the internal mechanism of executing process interpreted,and the experimental results show that the proposed algorithm has the optimization of quantum nature.


Scurrula ferruginea is a type of mistletoe from the Loranthaceae family found in Southeast Asia and distributed in tropical regions, is known to have healing effects for many disorders. Preservation of the bioactive metabolites is dependent on the sample preparation and drying methods as well as extraction solvents used. Thus, the present study was carried out to investigate the effect of different drying methods and extraction solvents on the total phenolic and the antioxidant activities of S. ferruginea leaves. The leaves of S. ferruginea were air and oven (60°C) dried and extracted with aqueous, organic and aqueous-organic solvents. The total phenolic content (TPC) and total flavonoid content (TFC) were used to gauge the phenolic antioxidants extracted, while the antioxidant activity was evaluated by measuring the scavenging effect on 2,2- diphenyl-1-picrylhydrazyl (DPPH) radical and via the ferric reducing antioxidant power (FRAP) assay. The optimum conditions obtained were oven drying, 80% acetone with values of 3.47 mg/10 g DW (extract yield), 171.29 mg GAE/1 g DW (TPC), 31.91 mg QE/1 g DW (TFC), 93.2% (DPPH), 26.41 mg TE/1 g DW (FRAP) and 7.41 μg/mL (IC50). The present findings suggested that sample preparation variability using different drying methods and solvents for extraction play a crucial role in enhancing the efficiency of extraction and efficacy of the antioxidant compounds in S. ferruginea leaf extracts.


The unbelievable properties of our information processing capabilities regarding the processing of big data, resilience, and energy efficiency are inspiration sources for the optimization and the rethinking of the principles of electronic information processing. Here, we present an approach of integrated circuits intended to solve chemical problems by active processing of chemical information.


Surface wet chemical oxidation is an efficient method to prepare nanostructure on copper foils toward realizing surface superhydrophobic property.However,the current studies mainly focus on the oxidation results but not on the process of oxidation reaction.Moreover,the characterization for superhydrophobicity is only by contact angle measurement.In this paper,three types of oxidants including K2S2O8,(NH4)2S2O8 and ammonia were separately applied to nano roughen copper surfaces.After been treated with fluorin containing silane,all as-prepared surfaces appeared superhydrophobic property but some showed strong resistance to vapor condensation while some did not.The influence of oxidant types on the resulting morphology was compared.The nanostructure growth was believed complying with the following procedure: copper oxidation,CuO hydrolysis,Cu(OH)2 complexation/dissolution,Cu(OH)2 re-deposition and crystal directional growth.The vapor condensation resistances of as-prepared superhydrophobic surfaces with different nanostructures,e.g.,microscopic mechanism of spontaneous motion of condensate droplets on them,were analyzed.It shows that only nanostructures with narrow space and high perpendicularity cause the obvious spontaneous motion of condensate droplets on them.


Abstract An economic and pollution-free technique for electroless chemical deposition of transparent and electrically conductive sub-micron films on the surfaces of glass, ceramics, transparent polyester films, metal, and ferroelectric thin films has been developed. The technique is based on hydrolytic decomposition of metal-thiosulfate or metal-selenosulfate complexes in aqueous solutions, and has been successfully used for deposition of transparent and electroconductive copper sulfide and copper selenide thin films of a variable composition. The basic optical and electrical characteristics of the as-deposited and annealed films are also reported. The Cu2S films were highly transparent (≥ 80 %) throughout the visible and near-infrared region of the electromagnetic spectrum (0.5 to 2.5 μm wavelength), while the rest of the films exhibited stoichiometrically adjustable absorbance in the near-infrared region (0.7 to 2.5 μm wavelength). The sheet resistivities of the films were found to be between 15 and 120...


Through a survey of more than 20 patients with a specific subgroup of autosomal recessive congenital cutis laxa (ARCL), namely ATP6V0A2‐related cutis laxa, we noted that the clinical findings on three patients included pretibial pseudo‐ecchymotic skin lesions very similar to those found in classical Ehlers–Danlos syndrome. The finding is apparently age‐related, occurring during the second decade in two of the three patients. © 2014 Wiley Periodicals, Inc.


Background and Objective: Parkinson's disease (PD) is a neurodegenerative disease with selective damage of mesencephalic dopaminergic neurons. Due to the protective, anti-inflammatory, and antioxidant effect of Hypericum perforatum (HP), this study was undertaken to assess dose-dependent effect of HP hydroalcoholic extract on motor imbalance following intrastriatal injection of 6hydroxydopamine in the rat.


ABSTRACT This study explores the effects of social capital on farmers' choices of climate change adaptation behavior in Dazu District, China. A total of 228 questionnaires were obtained from randomly sampled households. Social capital was divided into social networks, participation, reciprocity and trust. The adaptation behaviors in the study area were identified as crop adjustment, environmental improvement, financial management, and livelihood diversification. A boosted regression tree model was used to analyze the effects of different dimensions of social capital on farmers' choices of climate change adaptation behavior. The results show that most farmers in Dazu District of Chongqing have adopted crop adjustment adaptation behavior. The social capital and socioeconomic characteristics of farmers have different impacts on different adaptation behaviors. Among social capital, the largest influence on climate change adaptation behavior is the degree of trust in the information of agricultural technology extension service centers, and the lowest influence is participation in rural cooperatives. In terms of socioeconomic characteristics, the largest impact on climate change adaptation behavior is agricultural income share, and the lowest impact is gender. The findings of this study can provide empirical support for governments to formulate effective policies to improve farmers' climate change adaptation capabilities.


Mango (Mangifera indica L.) is a very important crop in tropical countries and Brazil is the seventh greatest producer in the world. In Brazil, mango is mainly consumed as fresh fruit, but consumption of processed products is increasing. Peroxidase is commonly associated with deterioration in flavor, color, texture and nutritional qualities of raw fruits and vegetables and is one of the most thermostable enzymes present in mangoes. Heat treatment of mango products is important to inactivate enzymes and to maintain the product quality. Two different heat exchangers were used in the pasteurization of 'Palmer' mango puree: a plate heat exchanger (holding tube volume: 75.8 cm 3 ) and a double-pipe heat exchanger (heating section area: 0.339 m2; holding tube volume: 71.6 cm 3 ). Different temperatures were tested: 75, 80 and 85 o C in the plate heat exchanger and 65, 70 and 75 o C in the double-pipe heat exchanger. It was not observed peroxidase activity in mango puree pasteurized at 80 and 85 o C; at 65, 70 and 75 o C, residual enzyme activity varied from 78.0 to 4.3 %. To complete this study, physical, chemical and sensorial analyses should be conducted to correlate peroxidase residual activity and mango puree quality.


Energy consumption has become one of the critical factors in MPSoC design.Especially,NoC(Network-on-Chip) contributes more than 50% of energy dissipation in the whole chip.After a uniform energy consumption behavior in the NoC application protocols is described,this paper analyses the processing detail of directory protocol that is a kind of widely used implementation of cache coherence protocol,and proposes an energy model based on the location probability distribution,which can locate the position of a basic data block(DB) in NoC by considering the irrelevance between the directory information and data location distribution,and calculate a probability matrix that denotes the transferring rate in any two nodes of NoC.While combining with the routing unit energy consumption,line energy consumption and network topology factors,single DB transferring energy consumption in the directory protocol can be accurately obtained.Simulation results show that this model can effectively compute the energy consumption of different kinds of directory protocols with stable transferring rate in Mesh networks,and a higher precision with less than 2% error is achieved.This model can also provide a credible quantitative criterion for the optimization of directory protocol energy consumption in the next step.


Inside of the city of Quito, the secondary effects caused by internal migratory phenomena are evident. Being the conurbation process, known as the progressive growth of the population of territory towards peripheral zones, the most notorious effect at an urban level. Moreover, it generates and exposes problematic series that must be faced by local governments such as: invasions, lack of basic services, and mobility, total or partial abandonment of consolidated areas, among others. These territory sections, in which population density is below its capacity, induce to progressive degradation, physical and social, of the consolidated areas; regardless their historical value and relevance inside cities development; as is the case of Mariscal Sucre parish, in which this singularity is clearly evident. Considering the influence of Educational Institutions in certain sectors and their dynamics, as well as the constant migratory processes, it is exposed the possibility of a gradual repopulation of the partly abandoned zones by external users, offering worthy living options according to their requirements and renewal period, as an initiative to stop the migration process to the cities peripheral zones.


The RHH's bone marrow (BM) or haematopoietic stem cell (HSC) transplantation program was established in 1979. We have since performed over 250 transplants. Our programme for autologous transplantation has distinguished itself from those of many other hospitals in three aspects: 1) Outpatient transplantation. In 1997 we introduced a system whereby the entire transplant process (pre-transplant chemotherapy, stem cell reinfusion, post-transplant care) is carried out on the day ward, so far as possible, aiming to minimise hospital admission. With a 30-day mortality rate of <2%, our program has proved to be safe and is much preferred by most patients. Our average length-of-stay is 8 days compared with national figures of around 21 days and about 10% of patients avoid hospital admission altogether. 2) Continued use of bone marrow as a stem cell source. While most BMT services have switched to peripheral blood (PB) as the sole source of haemopoietic stem cells, we have continued to use BM in certain circumstances. However in contrast to historical collection methods, we use G-CSF-stimulated BM which, compared with unstimulated BM results in more rapid engraftment. The advantages over PB HSCs include collection on a predefined single day, avoidance of need for insertion of large-bore central cannulas, and smaller volume for cryopreservation. 3) Rainy day HSC harvesting. When patients with lymphomas and some other malignancies relapse, cure may still be possible with a transplant using HSCs collected at that time. However there are theoretical and in some cases practical advantages in having HSCs collected and cryopreserved at the time of first remission. Our routine policy is to offer this to all our patients with NHL and high-risk Hodgkin's disease in first remission. We have cells stored from over 400 such patients. Our studies have shown that in vitro the cells retain adequate viability for safe transplantation for at least 14 years. We have reinfused HSCs from nearly 40 patients after storage of >1 year (maximum 9.3 years) without engraftment failure. The engraftment kinetics of cells reinfused after long-term cryopreservation appear similar to those after short-term storage. In summary, our innovative approaches to autologous BMT are potentially of benefit to a large number of patients requiring HSC services.


Colombia as a country with mega diversity has important competitiveness advantages in the global market of raw materials and essential natural ingredients for a larger number of industrial activities.However, current practices related to provision of natural ingredients derived from biodiversity show divergences in relation to the scope of norms on technology transfer written in several multilateral instruments.This document tackles the concept of knowledge management outsourcing within the context of public policies oriented to the commercial use of biodiversity resources, searching for ideal conditions which may favor delocalization of research and development activities for multinational corporations related to bio-prospection and basic research in such a way that biodiversity resources may be an object of aggregated value activities within the national territory.


s of recently accepted papers Scattered near-IR CO emission bands in GGD27-IRS: observing the circumstellar environment of heavily obscured young PMS stars.


Language is established by usage.Through a case study of the proverb"Kong-xue-lai-feng",the paper points out that the use or misuse of some words may result in the change in meaning.This process is one from a temporary change to a collective acceptance.Besides,morphological changes may result from the changed social restraint.There are quite a few such examples in the Chinese language.


Nonalcoholic hepatic fat accumulation has been hypothesized to be associated with alterations in gut microbiota composition, although mechanistic explanations for this link are largely insufficient. The aim of this study was to elucidate the microbiota‐driven mechanisms involved in the development of nonalcoholic hepatic steatosis.


Objective: Osteoporosis and osteoporotic fractures are widely prevalent in Indian subcontinent.Awareness of osteoporosis has grown worldwide in recent years as a major health problem having significant implications in day to day life.It isa common cause of morbidity andmortality in elderly people. Rapid bone loss occurring in postmenopausal women due to hormonal factors is a known fact. But there is a worrying trend of increasing prevalence of osteoporosis among the younger women in India. The occurrence of this disease among the male population also has been under studied. Materials and Methods: This cross-sectional study covered the 405 patients who attended a bone mineral density camp that was conducted in in a tertiary care hospital. The bone density of these people was measured using aquantitative ultrasound (QUS) machinestandardized to the Indian population. The significance of the results was calculated using the chi-square test. Results: Sixty people of the total hundred and five with age less than thirty years had decreased bone density(p< 0.001). The male population having decreased bone mass was also more than expected. Conclusions: Hence this study indicates that osteoporosis and osteopenia are prevalent in younger population too contrary to the popular belief. If detected earlier it can be treated and the morbidity caused by it can be avoided.