The distillery yeast biomass (DYB), a waste by-product from distilleries is one of the under-utilized protein sources to be exploited for the production of protein hydrolysates. In this study, a neutral protease produced from Bacillus megaterium PB4 isolated from agro wastes enriched soil exhibited significant deproteinization of distillery yeast biomass to yield protein hydrolysates. Among three protease producing strains isolated, the maximum protease production of 120.3 ± 1.4 U mL-1 was exhibited by PB4 grown in Luria-Bertani (LB) broth supplemented with casein at pH 7.0 and 30°C. The minimal media supplemented with various carbon and nitrogen sources, glucose and peptone significantly improved the protease production in PB4. The effect of metal ions such as Zn2+, Mg2+, Mn2+, Cu2+ at 0.5 and 1.0 mM final concentration in the media on protease production indicated that Zn2+ (1.0 mM) was favorable in enhancing the protease production. The Km and Vmax of PB4 protease for casein substrate was 0.6 U ml-1 and 217.3 μM min-1 mg-1 protein, respectively. The deproteinization rate for distillery yeast biomass was 84 and 76.4% using culture and crude enzyme extracted from PB4, respectively. To the best of our knowledge, deproteinization of distillery yeast biomass using proteolytic bacterial isolate has never been demonstrated before. The experimental results in the present study suggest that Bacillus megaterium PB4, can be utilized for the eco-friendly, economical production of protein hydrolysates and may be considered as a potential candidate in various biotechnological applications.


A simplified frequency-interleaved framework with digital back-end correction is presented for wideband analog-to-digital converters. Instead of channel-by-channel signal recovery, an iterative structure is proposed to simultaneously compensate the mismatches including in-phase/quadrature (I/Q) imbalances, jitter-induced distortions, as well as overlapping effects due to imperfect channel separation and incomplete anti-aliasing. The effectiveness of this novel architecture is validated via extensive simulations.


The use of activated charcoal from sawdust as an adsorbent of tetracycline hydrochloride compounds has been successfully carried out. Sawdust activated charcoal was carbonized at 450°C for 40 minutes with a charcoal size of 100 mesh and activated using H3PO4 solution. The characteristics of active sawdust charcoal showed that water content, iodine adsorption, and methylene blue adsorption had met SNI 06-3730-1995 regarding technical activated charcoal. Testing the morphology of charcoal using a Scanning Electron Microscope showed that the charcoal pores were opened through the activation process. In the functional group analysis test using infrared spectroscopy, the active group contained in charcoal after being activated contained carbon atoms that were purer than sawdust. The adsorption process of tetracycline hydrochloride using sawdust activated charcoal is known to follow Ho orPseudo second-order (K = 0.0039 g/mg.min), while the adsorption isotherm follows the Langmuir equation, KL = 0.0076 L/mg and adsorption capacity amounting to 242.1307 mg/g. Thermodynamically, the adsorption process occurs not spontaneously with a Gibbs free energy value of 120.8949 kJ/mol and occurs by chemisorption.


This study aimed to identify well-know psychology instruments used by psychology students and professionals and list used instruments in the sample. 82 senior students in a private university of Sao Paulo countryside participated in the study along with 52 professionals. The material used in this study comprised a setoff psychological assessment instruments and the task assigned to subjects was to check know, used and unknown tools. The task was performed during class hours, authorized by teachers and coordination. To collect data from majored professional, questionnaires were sent by mail because it is a self-applied questionnaire. Results indicated a difference between the 2 groups concerning well-know and used instruments by students and professionals. Studies show that some well-known instruments are also the most frequent in psychology courses. New researches on this topic should be done to gather further data.


Both future-oriented AGC(Automatic Generation Control) and spot power market need very short term load forecast. Based on the error source analysis of general extrapolation method, a multi-sample extrapolation method is presented. Stochastic signals and statistics theory are applied to analyze its precision. Practical results show that the proposed method lowers both average error and maximum error and improves forecasting precision. It is suitable for spot market for its convenience and practicality.


Clinical research on psychedelic-assisted psychotherapy is rapidly advancing in the USA, with two drugs, psilocybin and MDMA, progressing through a structure of FDA-approved trials on a trajectory toward Drug Enforcement Agency rescheduling for therapeutic use. Researcher's and clinician's personal use of psychedelics was cited as a potential confound in psychedelic research studies conducted in the 1950s and 1960s, a concern which contributed to the cessation of this research for some 20 years. Currently, there is no empirical research on personal use of psychedelics by current academic researchers and clinicians; its influence is undocumented, unknown, and undertheorized. This paper explores the history of personal use of psychedelics by clinicians and researchers, the potential impact of personal use on psychedelic-assisted psychotherapy and research, and the rationale for opening an academic discussion and program of research to investigate the role of personal use. We propose that there are factors u...


The invention relates to a method and apparatus for the conversion of raw gases in the entrained-flow gasification. According to the invention, the process for converting raw gases of entrained-flow gasification of carbonaceous feedstocks under pressure, wherein the drawn off from an entrained flow gasifier hot raw gases are injected in a downward flow in a quenching chamber, the upper part is designed as a gas chamber and its lower portion as a water bath, wherein the lower boundary of the gas chamber is formed by the water surface of the water bath, is injected at the quench water into the downward flow and the raw gases are cooled and the crude gases are drawn off above the water bath from the gas space, guided so that water only in the gas chamber is injected, surrounding the downward flow of the drawn off from the entrained flow gasifier hot raw gases, so that the humidified and above the water surface up the deflected crude gas cooled before it is in the downward flow einmi rule that the entrained with the raw gases secondary constituents by means of these raw gases during the cooling in the central zone of the down-flow and during the humidification and cooling in the annular zone of the upflow while enrichment held in the gas space in the balance solid incondensable secondary constituents catalytically with the raw gases enabled ...


The research analyzes the brand value and the saleroom of the corporations at first.And two vital relations between the brand value and the saleroom have been summed up.Then the function of relationship and the forecasting model of saleroom has been established based on them and on the VW model.And then the forecasting model of saleroom with the variable of brand vale has been got through solving the function of the relationship. At last the correctness and fitness of the relation function and the precision of the forecasting model have been validated with the real dates of Haier.The research has broken through the traditional forecasting model in the past.It is the first time to analyze the influence way to the saleroom by the angle of its brand value.The forecasting model of saleroom bases on brand value got by solving the relatively equation.This will more impersonality and more roundly scale the potential of the goods in the whole markets,and scale the saleroom in the future more accurately.


SnSe‐based materials have attracted widespread attention in thermoelectrics due to their outstanding thermoelectric performance. However, the pristine and unmodified polycrystalline SnSe reveals poor electrical properties. Doping and constructing nanostructured composite architectures to produce energy filtering effect proved to be an effective method to strengthen thermoelectric performance. In this study, Ti3C2/Sn0.98Cd0.02Se composites are successfully fabricated by the solvothermal method combined with the electrostatic self‐assembly method and spark plasma sintering. The phase interface introduced by incorporating Ti3C2 into Sn0.98Cd0.02Se can effectively filter low‐energy carriers due to its generation of energy barriers, thereby the Seebeck coefficient of x wt% Ti3C2/Sn0.98Cd0.02Se x = (0.05, 0.5, 1) samples is better than that of the pristine Sn0.98Cd0.02Se over the whole temperature range. Meanwhile, high conductivity was also obtained in 1 wt% Ti3C2/Sn0.98Cd0.02Se sample so that the high power factor of 3.31 μWcm−1K−2 was acquired at 773 K. Ultimately, a peak ZT value of 0.41 was obtained at 773 K, compared with pristine Sn0.98Cd0.02Se, and the thermoelectric performance improved by 24%. This study offers an available approach to efficiently enhance the thermoelectric properties of polycrystalline SnSe‐based materials.


50 mentally normal men who had been vasectomized in the years 1941-1949 were interviewed from 3 to 129 months after the operation (median = 55 months). Average time lost from work was less than 1 day. Few patients reported sexual changes. 5 reported a decrease in libido, but 9 reported an increase. Likewise, 4 reported lesser frequency of intercourse, but 8 reported greater frequency. 47 said they were satisfied with the results and "would do it again."


This paper examines the progressive deployment of the enterprise resource planning software package, MFG/PR0 by the Australian manufacturing and distribution conglomerate CSR Ltd. within its forestry and forest products divisions. Reasons for initial deployment and the ostensible range of benefits obtained subsequent to initial deployment were investigated, as was the recent sale of the majority of the primary productive resources of the same divisions. It was found that initial reasons for deployment included the expected financial and operational benefits allowing from installing material requirements planning (MRP) software, such deployment integrating the production and inventory management of a range of interrelated forest products. These benefits were realised. Most recently, following a strategic decision by management to narrow CSR's business portfolio, all of the forest resource and much of the infrastructure was divested. Control of the formerly owned forest products based supply chain of the building materials division is being achieved however through the strategic information systems application of cross-organisational enterprise resource planning (ERP) systems.


The purpose of writing this research is to conducted an in-depth analytical and research study of the epistemology of value education in terms of contemporary Islamic educational philosophy. This study used a type of qualitative research with an approach literature research methods. This article was an attempt from the epistymology of value education in caried out its transformation through contemporary Islamic educational philosophy. Contemporary Islamic educational philosophy showen that with the concept of epistimology, value education can lead to students who were broad-minded, knowledgeable, and independent. In an expression said that an educational renewal can be well directed if it was based on a solid educational philosophical and theoretical framework.


We present isotopically engineered Si-28/SiGe heterostructures for development of silicon-based quantum computers using a standard silicon CMOS integration technology. Our Si-28 quantum-wells are well-strained and demonstrate high electron mobility and large valley-splitting. These properties provide promising platforms for realization of highly integrated spin qubits working together with silicon CMOS circuits.


Due to its location in the transition region between the Black sea and Eastearn Anatolia of Bayburt province, it has deep-rooted historical and cultural riches. History of the city it goes down to 4000 years. It has been home to different civilizations from the time it was established to the present day and the culture, life and beliefs of these civilizations have shaped both the city center and the rural settlements. The name of the city with different names in the source, Evliya Celebi in the chronicle of the "rich country" means that the Bayyurt emerges. The rich history of the city, in both urban and rural settlements, has brought unique features to living spaces and architecture. Climate, social-economic structure and environmental factors have been important in shaping rural architecture. Houses that constitute a large part of the rural architectural heritage of Bayburt are not registered and protected. These houses, which were not taken under protection, were in the process of disappearing from time to time because of be abondoned of the houses and construction of new houses. These houses reflect all the fineness of rural life and have an important heritage value in terms of cultural assets. This heritage must be protected by holistic and appropriate approaches and transferred to future generations. Within the scope of this study, photographing, surveying and observation techniques were carried out in 11 villages of Bayburt rural house architecture. The data obtained from the field work was analyzed and typologies were formed by analyzing the architectural features of the houses. In addition, houses were examined for environmental data, building materials, construction techniques, plan, facade and other structural elements. Analysis results are presented with tables and visual material.


"From the Spanish attempt to settle nothing permanent resulted. The second establishment within what is now our state was by the British overland from Canada."


We read with interest your recent article entitled "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and Transfusion Medicine: reflections from Italy" 1 . We would like to discuss another blood-derived source at potential risk for SARS-CoV-2 transmission that is represented by homologous products applied as eye drops for the treatment of severe corneal diseases. Since the use of these products in ophthalmic practice is increasing, and the duration of the pandemic is currently unpredictable, we believe this issue is worthy of consideration.


The Generation IV International Forum has selected six promising nuclear power systems for further collaborative investigations and development. Among these six concepts, two candidates are Gas Cooled Reactors (GCR), namely the Very High Temperature Reactor (VHTR) and the Gas‐cooled Fast Reactor (GFR). The CEA has launched a R&D program on the metallic materials for application in an innovative GCR. Structural GCR alloys have been extensively studied in the past three decades. Some critical aspects for the steels and nickel base alloys resistance under the service conditions are microstructural stability, creep strength and compatibility with the cooling gas. The coolant, namely helium, proved to contain impurities mainly H2, CO, CH4, N2 and steam in the microbar range that interact with metals at high temperature. Surface scale formation, bulk carburisation and/or decarburisation can occur, depending on the atmosphere characteristics, primarily the effective oxygen partial pressure and carbon activity, on the temperature and on the alloys chemical composition. These structural transformations can notably influence the mechanical properties: carburisation may induce a loss in toughness and ductility whereas decarburisation impedes the creep strength.


To investigate whether chromosomally normal fetuses with a nuchal translucency (NT) ≥ 99th percentile (3.5 mm) in the first trimester have an increased risk of delayed development at 2 years of age.


This article analyses the phenomena of territorial control that is carried on by small scale drug trafficking groups in Latin American cities. It shows that existing publications on this topic take for granted what "territorial control" is, but end up referring to different social processes. Leaning in the concepts of territory, territoriality and territorialization, the author defines which elements shape the different modalities of territorial control implemented by small scale drug trafficking groups. In this way, he provides an analytical tool composed by different indicators: who are the subjects controlled by drug gangs, what is the extension, modality and objectives of territorial control and how do these groups influence political and associative life as well as other spheres of everyday life of the communities in which they are located.


Recently, an Expected Patch Log Likelihood (EPLL) method is presented for image denoising, which can well restore details of natural images. However, the EPLL is viewed as a local method, and seldom takes into account the relationship among patches. In this paper, a non-local EPLL algorithm using eigenvectors of the graph Laplacian of patches is proposed to fully exploit such relationship. In detail, the eigenvectors of the graph Laplacian are incorporated as basis functions to employ the geometrical structures of patches. Meanwhile, the residual error constraint is considered to deal with the noise corruption in the iterative procedure. Sequently, an eigenvector-based EPLL problem is presented under a set of residual error constraints, and the corresponding approximate solution is efficiently provided. Experiments show that the proposed algorithm can achieve a better performance than the traditional EPLL, and is comparable with some other state-of-art denoising methods.


In this paper, we identified how the growth environment chemistry can critically influence the type and nature of the incorporated K defect in ZnO films grown using the aqueous solution route, which explains the switching between p- and n-type conductivities under different doping or thermal annealing conditions. This was achieved by relating the growth environment to the structural, optical, and electrical characteristics of the films. The thermal behavior of these defects up to 700 °C confirms the proposed doping mechanism. It is found that the best route to realizing p-type conductivity is through minimizing the amount of Ki and KZn–Ki complexes because films with high concentrations of Ki have a slow p-type recovery caused by the slow out-diffusion of Ki. The highest hole concentrations for as-grown films and those that were annealed at 700 °C for 30 min were 2.6 × 1016 and 3.2 × 1017 cm–3, respectively. The upper limit for p-type doping using this route appears to be about mid-1017 cm–3. Our results ...


This article presents the design and application of a Modified Sociotechnical Systems (MoSTS) methodology for holistic analysis of complex technical processes. Successes and failures of process redesign initiatives have demonstrated the strong influence of human elements on outcomes. (Sociotechnical Systems) STS provides a foundation for structured analysis and redesign of complex processes which emphasizes human aspects in process redesign. The MoSTS methodology is developed from STS research and practice and applied to analyze a complex technical process in the research and development sector. MoSTS is shown to be an effective methodology to facilitate analysis for process redesign, particularly where human influences may have a significant impact on success. The article concludes with limitations and implications for process analysis based on the MoSTS methodology application.


Efficient bioluminescence resonance energy transfer (BRET) from a bioluminescent protein to a fluorescent protein with high fluorescent quantum yield has been utilized to enhance luminescence intensity, allowing single-cell imaging in near real time without external light illumination. We have applied this strategy to develop an autoluminescent Ca2+ indicator, BRAC, which is composed of Ca2+-binding protein, calmodulin, and its target peptide, M13, sandwiched between a yellow fluorescent protein variant, Venus, and an enhanced Renilla luciferase, RLuc8. With this BRAC, we succeeded visualization of Ca2+ dynamics at the single-cell level with temporal resolution at 1 Hz. Moreover, BRAC signals were acquired by ratiometric imaging capable of canceling out Ca2+-independent signal drifts due to change in cell shape, focus shift, etc. Taking advantage of the bioluminescence imaging property that does not require external excitation light, BRAC might become a powerful tool applicable in conjunction with so-called optogenetic technology by which we can control cellular and protein function by light illumination.


In the unit viewing sphere imaging model, the projection of a space sphere includes the sphere image and its antipodal sphere image. As the pair of sphere images are separated, they have only one common self-polar triangle. In this study, a method for homography estimation based on the projection of the space sphere is proposed, which involves using a paracatadioptric camera. The proposed method requires two images of the space sphere from different positions to obtain a homography matrix. This homography matrix has eight degrees of freedom, and a line correspondence pair provides two constraints. Hence, using four pairs of line correspondences, the homography matrix can be solved, and the external parameters can be obtained. The effectiveness of the proposed method is verified through simulation and experiments using real images.


This study examines effects of negative campaigning by political parties on citizens' electoral preferences in the 2015 General Election in England. We do so by using a large Internet panel study and an operationalisation of (perceived) negative campaigning that avoids social desirability. Our study acknowledges England's multiparty system by distinguishing between the campaign tones of all parties. Potential problems of endogeneity are addressed by leveraging the panel structure of the data and by extensive controls. We find that electoral preferences are weakened for parties engaging in negative campaigning and that this backlash effect gets stronger over the course of the campaign. We also find support for a second-preferences boost hypothesis: preferences for one's second-most preferred party are strengthened if its campaign is more positive than that of one's most-preferred party.


In this paper, a method for introducing active damping for a diaphragm in a micromachined directional microphone is considered. The sigma-delta modulation is used to circumvent the nonlinearity of the capacitive transducers of the microphone. The principle of operation of the damping scheme is explained, and the simulation results of a lumped diaphragm model are presented.


8005Background: Preclinical studies from our laboratory have demonstrated that ruxolitinib (RUX) in combination with lenalidomide (LEN) and dexamethasone shows marked anti-myeloma effects both in vitro and in vivo. Furthermore, MUC1 is responsible for LEN resistance in MM cells, and RUX blocks its expression in MM cells. Thus, RUX may restore sensitivity to LEN. Therefore, a phase 1 trial was conducted to determine the safety and efficacy of RUX in combination with LEN and methylprednisolone (MP) for relapsed/refractory (RR)MM patients (pts) who had previously been treated with LEN/steroids and a PI and showed progressive disease at study entry. Methods: A traditional 3+3 dose escalation design was used to enroll subjects in four cohorts with planned total enrollment to be 28 pts. Subjects received RUX twice daily continuously, LEN daily on d1-21 of a 28-d cycle and MP orally every other day. In DL0, pts received RUX 5 mg, LEN 5 mg, and MP 40 mg. In DL+1 and +2, both doses of LEN and MP remained unchanged...


The present study was carried out to evaluate the presence of active phytochemicals in ethanolic extract of rhizomes of Zingiber officinale following GC-MS method. The qualitative phytochemical screening of ethanolic extract of Zingiber officinale rhizomes revealed the presence of alkaloids, glyocosides, saponins, Tannin and flavonoids, reducing sugars. Gas chromatography and mass spectroscopy analysis of ethanolic extract of Zingiber officinale showed the presence of 12 major components as Isopropenyl dimethyl, 3-Allyl 6 methoxyphenol, Thujaketone, 2 Butanoic acid, 2 methoxy methyl, Hexahydro farnesol, Gingerol, Tetradecanoic acid, 1 Phenyl 3-6 diazohomoadamantan-9-hydrozone, 7-methyl-2tetradecen-1-ol-acetate, Eicosane, Androstan and Squalene. From the study, it was concluded that Zingiber officinale possesses significant bioactive compounds having therapeutic effects, hence can be considered as a potential of medicinal herb.


The spacial distribution pattern of Frankliniella occidental on Trifolium repens were examined by five aggregation indices and linear regression analysis,the results show that the spacial distribution pattern of Frankliniella occidentalis on Trifolium repens is Aggregated distribution,the basic ingredients is individual population,the individual attracted each other,the aggregation was caused by the environmental factor.A Theoretical sampling model was built by Iwao's way(regressive relation by m*-m),theoretical sampling numbers of field survey can be estimated with N=1/D2(1.3533/m+1.964).


ON MY WAY TO EAST LONDON from a Shakespeare's Globe performance in August 2017, I noticed an advertisement in one of the Tube stations. Accompanying the billing for the Royal Academy of Arts' exhibition, Matisse in the Studio, was a quotation from Henri: "a good actor can have a part in ten different plays; an object can play a role in ten different pictures." It is from Museum Studies that we borrow the word curation: the selection and arrangement of preexisting art objects for a particular experience. But this notion of curation has now overleaped the bounds of the art world; "content curation" is the stock-in-trade of every major marketing, consulting, and Big Data firm—from fashion to Facebook, from American Girl to the American Dream. The concept of curation, which exploded in the 1970s art world and again in the 2000s web-based economy, is much older than Matisse's nineteenth century, however. In this essay, I argue that curation is a hermeneutic equipped to account for repertory economics that structured the sixteenthcentury theater industry. Pre-Shakespearean cases will exemplify how the field of Shakespeare Studies' approach to troupes could evolve using this transdisciplinary paradigm.


Thermogravimetric, metallographic, and X-ray studies of a model alloy, Ni-(17 a/o)Al-(10 a/o)Mo+W, oxidized in dry air at 600-1200 C and in air with 10 ppm NaCl gas at 900 C, are reported. The alloy was melted under Ar and pretreated in flowing H2 for 24 h at 1300 C. Polished 1.3 x 1.3 x 0.2-cm specimens were washed and degreased prior to oxidation in a quartz tube within a furnace for up to 120 hr. The oxidation activation energy of the alloy is determined to be about 30 kcal/mole. The specimens oxidized at 900 C and hotter exhibited oxidized and nitrided phases covered by complex NiMoO4, NiWO4, and NiAl2O4 scales and a porous, nonprotective outer layer of NiO. The oxidation behavior is found to be determined by the formation and growth of the scale, especially the (Mo,W)O2 component. Al2O3 scale layers were not formed, and further runs with pure O2 or Ar-(20 percent)O2 ruled out an explanation of this phenomenon based on aluminum nitride formation. The oxidation was accelerated by the addition of NaCl gas, a finding attributed to the reaction of NaCl with external locally protective Al2O3 scales and with the internal(Mo, W)O2 layers.


In th is paper, three k inds o f tem poral ce n tra lity o f nodes in com plex ne tw orks were predicted. T h ro u g h the analysis o f the tem poral cen tra lity values o f nodes at d iffe ren t tim es in the real datasets, i t can be found th a t tem poral ce n tra lity values o f nodes in d iffe re n t tim es are h ig h ly correlated. Based on th is observation, we proposed several predic t io n methods to p red ic t the tem poral cen tra lity values o f nodes in the fu tu re in real datasets. T he n , th rough the e rro r analysis between the real values and predicted values ? the performance o f d iffe re n t p red ic tion methods in d iffe re n t real data sets was compared. T he resu lts show th a t the recent weighted average m ethod perform s best in the M IT rea lity trace ,and the recent u n ifo rm average m ethod perform s best in the In focom 06 trace.


The mechanical properties of walnuts shells composites were studied. The range of added walnuts shells has the values (0%, 2.5%, 5%, 10%, 15%, 20%, and 25%) of polyethylene weight and, the best fibers ratio was 10 % and 15 %. Obvious improvement in the mechanical parameters was recorded when adding walnuts shells with 10% weight ratio. The properties (LDPE /walnuts shells ) composites were analyzed as a function of the powder amount. All prepared composites showed improved powder dispersion in the low density polyethylene matrix. All composites displayed lower elongation of break compared to pure LDPE. The best added ratio was 15% of LDPE weight which gave Proportional limits 140 N.


Due to changes in the roles of pharmacists in the clinical field, a lengthening of the mandatory study period at pharmacy school is currently being considered. We therefore conducted a survey of the practical training included in the postgraduate hospital pharmacy courses with the aim of exploring the possible forms of the longterm practical training which may be necessary in the future. An analysis of eleven reports on practical training in hospitals and 46 questionnaires completed by students who had completed hospital training suggested that the acquisition of patient oriented pharmaceutical care, which is seen as one of the main aims of such training had, to a large extent, been successfully achieved, however, the ability to identify pharmaceutical problems in the clinical environment had not yet been adequately developed in most students. Most students considered hospital training to be a positive experience but also indicated problems regarding the curriculum, coordination between the university and the training institutions, and the resources of the training institutions. In order to educate fully capable pharmacists, closer coordination and cooperation between the universities and the medical treatment institutions is thus called for in future.


This research aims to clarify the nature of the links between brand portfolio management, competences and competitive advantage. In a series of interviews within four different cosmetics companies, the author explores their approach to managing the brands they own. This work shows that brand portfolio management is enmeshed in an ensemble of competences acquired over time which are part of the companies' history. The reality that emerges is that a brand portfolio strategy once truly established in an organisation, makes replication by a competitor very difficult due to the in determinability of the causes and effects, and also because it takes a long period of time to build the relevant competencies.


Arterial stiffness and enhanced wave reflections independently predict cardiovascular risk. Wave reflections augment central (aortic) pulse pressure (PP), an index of arterial stiffness, and systolic pressure. Increased wave reflections and PP have previously been associated with endothelial dysfunction in hypertensive and healthy middle-aged adults. The study objective was to determine whether endothelial dysfunction is associated with PP and other measures of vascular stiffness in young normotensive and prehypertensive subjects. We measured office, central, and 24-hour measurements in 102 (64 female, 38 male) non-hypertensive, non-diabetic participants. Endothelial function was assessed non-invasively using post-ischemic reactive hyperemia with strain-gauge plethysmography. The racially diverse subject pool was comprised of 60% Caucasians, 18% African Americans, and 24% Asians, with mean age 30, mean BMI 25.6, mean office SBP/DBP = 110 ± 13 mm Hg/70 ± 9 mm Hg. Endothelial function was highly associated with office (β= - 4.2 mm Hg, p In conclusion, endothelial dysfunction is significantly and consistently associated with arterial stiffness and increased wave reflections in young non-hypertensive adults. Identification of endothelial dysfunction in otherwise healthy young individuals may provide an opportunity to reduce vascular stiffness and associated cardiovascular risk.


General Operations of a Nonprofit Organization Boards of Directors and Conflicts and Liability Private Inurement and Private Benefit Lobbying Political Activities Public Charity Status Fund-Raising Regulation Planned Giving Fund-Raisers' Inquiries Unrelated Business Activities Subsidiaries IRS Audits of Nonprofit Organizations Endnotes Index.


Chongqing minority area is mainly inhibited by Tujia,Miao and other ethnic minorities.For a long time,due to its historical,geographical environment and the existing policies and other factors,there are many problems of its urban development.Through the analysis of the status quo of Chongqing urban system in minority area,this article explores its problems,putting forward some countermeasures,and displaying the importance of its development.


The role of race in medical decision-making has been a contentious issue. Insights from history and population genetics suggest considering race as a differentiating marker for medical practices can be influenced by systemic bias, leading to serious errors. This may negatively impact treatment of complex diseases such as cardiovascular disease (CVD). We seek to identify instrumental variables and independently verifiable epidemiological tests of whether diagnoses and treatments impacting severe cardiovascular conditions are racially linked. Using data from the UK Biobank (UKB), we found minimal, non-significant racial differences in log odds ratio (OR) between a range of cardiovascular outcomes such as atrial fibrillation, coronary artery disease, coronary thrombosis, heart failure and cardiac fatality. Genetics classification with respect to principal components vs. racial identification of Black British showed no significant differences in diagnoses or therapeutics for CVD related diseases and their associated comorbidities. However, Black British had significant risk of association with genetically predisposed risk of CVD as captured by polygenic risk scores (PRS) of CVD (OR=1.12; 95%CI:1.034-1.223; $p < 0.006$) as well as in 14 related traits. We used a sub-population based feature selection method to find Townsend Deprivation Index, smoking history, hypertension, PRS for ischemic stroke, low density lipoprotein cholesterol, and type II diabetes as the top features predicting the ethnographic category of Black British with an AUC of 79.5%. Therefore, PRS can be used to understand racial disparities in disease outcome which is otherwise not reflected in clinical factors such as diagnoses outcome status or therapeutics in large observational cohorts such as UKB. PRS yield better predictive power with underrepresented minorities and can improve clinical decision-making.


The title of this article is "Moriond 2012 Higgs Summary" or perhaps I should be calling it the "Brout-Englert-Higgs" Summary or even the "SM scalar boson" Summary. These were the titles diplomatically chosen by the speakers in the presence of Francois Englert who gave the opening talk for the session, but the particle is still symbolised by just the letter H. The Moriond meeting has seen another small step forward in the search for the missing boson with new data coming from the Tevatron and LHC experiments. Now that all the plots are available online it's a good time to pick out a few highlights and see what they are telling us.


• The possibility that stones in the common bile duct may disappear during conservative treatment with 3 to 4 Gm. of bile salts per day by mouth is illustrated by the histories of nine patients selected from a larger series of patients who have undergone cholecystectomy and choledochostomy with insertion of a T-tube in the common duct. The nine patients constituted a group in whom postoperative cholangiography gave evidence of retained or recurrent stones and in whom obstruction of bile flow was incomplete so that the T-tube could be clamped all the time. In seven of these patients, the "stone" shadows vanished in 8 to 13 weeks. In two, the shadows persisted, and stones were removed at a subsequent operation. Proof that the shadows represented stones and that the administration of bile salts played a decisive part in their disappearance was not absolute, and the question whether the stones disintegrated, dissolved, or passed unchanged was not settled, but significant evidence relating to these problems was obtained.


Abstract Targeted delivery of potent cytotoxic drugs to cancer cells minimizes systemic toxicity and several side effects. NHC*−Au−Cl has already been proven to be a potent anticancer agent. In this study, we explore a strategy based on chemoselective cysteine conjugation of NHC*−Au−Cl to albumin and trastuzumab (Thiomab LC‐V205C) to potentiate drug‐ligand ratio, pharmacokinetics, as well as drug efficacy and safety. This strategy is a step forward towards the use of gold‐based anticancer agents as targeted therapies.


(Received April 6, 1982) The quality of two kinds of commercial pindolol tablets, uncoated A and sugarcoated B, was evaluated by 3 tests: dissolution, weight variation, and content uniformity. The dissolution test was made with Sartorius Solubility Simulator. The weight variation test was made according to the method prescribed in J. P. X. In the content uniformity test, both tablets A and B were dissolved in 0.1 N HCL solution. Pindolol was determined spectrophotometrically. Following results were obtained: 1) In the dissolution test, 50% dissolution time of the two kinds of tablets was almost the same. However, the dissolution ratio at 5 min of the tablet A was significantly higher than that of the tablet B. 2) In the weight variation test, the tablet A met the criteria of J. P. X, and the weight variation of the tablet B was also very small. 3) In the content uniformity test, the mean contents of the two tablets were about 100%. Keywords-pindolol; dissolution; Sartorius Solubility Simulator (S. S. S.); weight variation; content uriformity


This paper looks at the evolution of fertility in Italy from the 1960s to the 1990s, using a statistical analysis as its methodology. The article also tries to develop a hypothesis taken from the analysis while considering the problems and complexities of theorizing from perceived any patterns and trends observed in the reproductive process. The two methods of analysis used look at the general European and specifically Italian demographic structures in evidence.


A high performance soft x-ray appearance potential spectroscopy (SXAPS) system has been designed and built. Non-derivative spectra (without using a lock-in-amplifier) are measured at a few A incident electron currents on samples. This is about 1/1000 of typical electron currents for SXAPS measurements. A new analytical method to obtain local density of empty states is developed. SXAPS Cr 2p spectra of a Cr(110) surface have been measured by the system and density of empty states is deduced by using the method. The result is compared with x-ray absorption spectroscopy (XAS) and electron energy loss spectroscopy (EELS) spectra, and a theoretical calculation. The present result indicates that local density of empty states for material surfaces can be easily deduced by the analytical method.


We present sensitivity projections for discovering a heavy resonance decaying to electron and muon pairs and for probing the charged lepton nonuniversality in such decays at the High Luminosity Large Hadron Collider (HL-LHC) and hadron-hadron Future Circular Collider (FCC-hh). The analysis takes into account the expected differences in the reconstruction efficiencies and the di-lepton mass resolutions for di-electron and di-muon final states. We demonstrate how the analyses at HL-LHC naturally pave the way for a FCC-hh machine thereby underlining its importance.


Byline: R. Murthy, S. Khandelwal Historical Development of Mental Health Services During the last three centuries, there has been major shifts in the way mentally ill are viewed and cared for all over the world. The changes during the last 50 years are most significant. From a situation of considering the "mad" as "bad" and incarceration in jails and asylums, there is now recognition of the human rights of the mentally ill. From jails and asylums, the care of the mentally ill persons has moved to the community. Another important development is the care providers. Current approach to care in the community includes, besides psychiatrists, other mental-health professionals, primary-care doctors, family members, volunteers and the ill persons. The driving forces towards these changes have been many: the recognition of the wide range of mental disorders, the high prevalence of mental disorders in the community, the availability of a variety of interventions (pharmacological and nonpharmacological), the demonstration of the effectiveness. Human Resources for Health Care There is an international focus on human resources for health care. The theme of the World Health Report 2006 (WHR 2006) was Working Together for Health. The WHR 2006 begins with the following observation: "In this decade of the 21[sup] st century, immense advances in human well-being coexist with extreme deprivation. In global health we are witnessing the benefits of new medicines and technologies. But there are unprecedented reversals. Life expectancies have collapsed in some of the poorest countries to half the level of the richest - attributable to the ravages of HIV/AIDS in parts of sub-Saharan Africa and to more than a dozen "failed states". These setbacks have been accompanied by growing fears, in rich and poor countries alike, of new infectious threats such as SARS and avian influenza and "hidden" behavioural conditions such as mental disorders (emphasis added) and domestic violence ."(xv) (emphasis added). Further, the report states The ultimate goal of health workforce strategies is a delivery system that can guarantee universal access to health care and social protection to all citizens in every country. There is no global blueprint that describes how to get there - each nation must devise its own plan. Effective workforce strategies must be matched to a country's unique situation and based on social consensus (emphasis added). (p.119) The human resources for mental health care are grossly inadequate in the developing countries, as presented by the WHO Atlas document in 2005. In the Indian context, the development of appropriate human resources for health in general is receiving serious attention. For example, the setting up of the Public Health Foundation of India in 2006 is a good example of this concern. Both authors come from a background of community mental health and experience of training and working with primary health-care doctors. The effort is to present the "world" perspective (from the World Health Report, the World Psychiatric Association (WPA) guidelines, experiences of different countries) and identify some issues relevant to undergraduate education in India. World Health Report 2001 The World Health Report 2001 makes 10 overall recommendations. The first of this is "Provide treatment in primary care." The management and treatment of mental disorders in primary care is a fundamental step which enables the largest number of people to get easier and faster access to services. It is to be recognized that many are already seeking help at this level. This not only gives better care but also cuts wastage resulting from unnecessary investigations and inappropriate and nonspecific treatments. For this to happen, however, general health personnel need to be trained in the essential skills of mental health care. Such training ensures the best use of the available knowledge for the largest number of people and makes possible the immediate application of interventions. …


The utility model discloses an infusion pipe anti-upside down device and an infusion pump. The infusion pipe anti-upside down device comprises an anti-upside down pipe sleeve and a slot. The two ends of the anti-upside down pipe sleeve is asymmetric structure. The shape of the slot is matched with anti-upside down pipe sleeve which is connected to the outside of the infusion pump in a sleeve joint mode. The slot is arranged on the shell of the infusion pump. The anti-upside down pipe sleeve is arranged inside the slot in forward direction. The infusion pipe anti-upside down device avoided the upside down of the infusion pipe, and the safety of the infusion pipe is improved.


A series of lanthanide metal complexes [Ln = Sm (1 and 5), Eu (2 and 6), Tb (3 and 7), Er (4 and 8)] were synthesized with imidazole-containing β-diketone ligands. Complexes 1–8 were characterized by IR, elemental analysis, powder XRD, and TG measurements. The photoluminescence properties and the probable mechanism of the Sm, Eu, and Tb complexes were studied. The Eu complex gener-


The transepidermal water loss is high in the newborn with a very low weight (ELBW) at birth. Recent studies show that the use of Tegaderm® in the ELBW newborn significantly reduces the problems resulting from the loss of water through the epidermis. A hypopigmentation secondary to the use of Tegaderm® was described.


The intent of this investigation is the determination of the values of the Cs-133 (n,2n)Cs-132 cross-section at neutron energies of 15.6 and 16.1 MeV. Neutrons of this energy are produced with comparative ease by means of the D-T reaction, in which deuterons of energy 500 and 750 keV, respectively, are impingent upon a tritium target.


Hydrogen-oxygen Regenerative Fuel Cell (RFC) is a kind of energy storage plant, which is suitable for satellite and space station especially. A RFC acts as electric battery and shifts energy from the lightside of the orbit to the nightside. It consists of a fuel cell subsystem and an electrolyzer subsystem. During power drawing operations, a fuel cell generates energy by combining hydrogen and oxygen gas to form water. During charging operations, an electrolyzer is used to covert water back into its constituent part, hydrogen and oxygen. Comparing with other RFC systems, Proton Exchange Membrane Regenerative Fuel Cell (PEMRFC) has many advantages, such as, solid non-corrosive electrolyte, low temperature operation, rapid start up, high power density, simple design, and ease of manufacture etc.
In this paper, a lOOw H₂/O₂PEM RFC system in lab is presented. It consists of RFC stack, water-circulating loop, and the supply and the storage for hydrogen and oxygen. Water management is very important for RFC, where water should function as both reactant and product, so keeping balance and recoverable for water is necessary. For this purpose, we design FC stack with passive water removal [1], and adopt a special gas-liquid separator, which needn´t depending on gravity to separate gas and water and suitable for weightless space application. The RFC stack and system gives a good performance in 50-cycle test.


Review(s) of: Practical Interventions for Young People at Risk, edited by Kathryn Geldard, (2009), London: Sage. 206pp. ISBN 9 781847 875624.


Roof Gardens, Backyard Gardens, Allotment Gardens, Community Gardens and Road side Gardens were part of green development in urban areas. The present irrigation facilities for these gardening are fulfilled by potable water from water treatment plants. The demand of water for irrigation of urban gardens is increasing day by day. Around 60% of total water used in kitchen was converted in the form of wastewater. The biodegradable organic constituents present are around 80% in kitchen wastewater. In the present practices highly concentrated kitchen wastewater is disposed off in municipal sewers or inland water bodies or on land directly. These practices are preliminarily responsible for pollution of ambient atmosphere. Also the plant nutrients present in kitchen wastewater are wasted. The objective of this study is to recycle the SBR treated centralized kitchen wastewater for Urban Irrigation. The research study includes a comparative study to determine quality of soil irrigated with Potable Water (PW), Treated Kitchen Waste Water (TKW) and Untreated Kitchen Wastewater (UKW). During this work growth of plants also observed with respect to quality of water used for irrigation.


In this paper, the periodic event-triggered system (PETS) under random deception attacks is studied. In the concerned system, a detector with system state and predicted state as input is used to detect deception attacks. The detectors have different detection results in the presence and absence of noise. To address these differences, state estimator update strategies are designed and the mean-square stability of the system states is ensured, respectively. With the design of the controller and state estimator, we can guarantee exponential convergence of the system state once the communication network is attacked. Finally, the paper proposes sufficient conditions for deception attacks and minimum bit rates that ensure the stability of the system.


Manoela dos Anjos Afonso Rodrigues teaches in the Faculty of Visual Arts at the Federal University of Goias. In the Art and Visual Culture Graduate Program, she conducts and supervises arts-based research focused on the intersections between the visual arts and autobiography studies. The notion of autobiogeography has informed her self-positioning strategies for enunciating life stories through creative practices related to space and place concepts, rearticulating and reinventing autobiographical perceptions.


Speeches of fictional characters are an important part at the discourse level to express meaning and attitudes,and affect the interpretation of the story.The ways of translators to deal with the speeches can show the effect they aim to achieve.The same speeches in different forms can produce different meanings.Translators' manipulation at the discourse level can affect readers' attitudes and purposes towards the fictional speeches to achieve their aesthetic objectives and realize the ideological purposes in the target culture norms.


A direct frequency-conversion third-harmonic-generation system pumped by a tunable amplified femtosecond laser is developed for OH and CO planar imaging. Increased output energies and the robust operation enables high-fidelity single-shot OH images in turbulent flames.


Additive, dominance and epistasis components of genetic variation for yield and some yield related traits were assessed through modified triple test cross technique in Basmati rice. Epistasis was found an important part of genetic variation for plant height, tillers per plant, secondary branches per panicle, grains per panicle, 1000-grain weight and yield per plant except primary branches per panicle and panicle length. Bifurcation of epistasis showed that additive x additive (i) type and additive x dominance + dominance x dominance (j + l) types of non-allelic interactions were involved in the expression of these traits. Additive and dominance type of gene action influenced the expression of primary branches per panicle and panicle length. No evidence of directional dominance was observed for these two traits. For plant height, tillers per plant, secondary branches per panicle, grains per panicle, 1000-grain weight and yield per plant, recurrent selection or biparental mating may be exercised in F2 and following generations however, selection of desired plants may be postponed till F5 or F6 generations to permit maximum obsession of epistatic effects to develop desired cultivar(s) in Basmati rice.


Adaptation of not Russian speaking students from the ethnic youth of russian regions and foreign students from nearand far-abroad to the study activities in Russian chemical profile institutes of higher education was investigated. The basis of adaptation training of the students to natural sciences disciplines is using their mother tongue as a training means with the aid of semantisation of notion-terminological instrument of learning discipline. A such approach to training of the speaking another language students is realized by using educational-methodological complex which includes educational supplies, methodical instructions, individual work, terminological dictionaries, nomenclatures of the chemical compounds devised in two training languages. The bilingual training means are combined with corresponding forms and methods of teaching, which intensifies an adaptation of speaking another language students to the educational activity in russian speaking institutes of higher education.


The most important theories in fundamental physics, quantum mechanics and statistical mechanics, posit objective probabilities or chances. As important as chance is there is little agreement about what it is. The usual "interpretations of probability" give very different accounts of chance and there is disagreement concerning which, if any, is capable of accounting for its role in physics. David Lewis has contributed enormously to improving this situation. In his classic paper "A Subjectivist's Guide to Objective Chance" he described a framework for representing single case objective chances, showed how they are connected to subjective credences, and sketched a novel account what they are within his Humean account of scientific laws. Here I will describe these contributions and add a little to them.


There are hordes of data-driven, context-aware, and people-centric applications and services for smarter environments such as smarter homes, governments, buildings, cities, and organizations. With the exponential growth of smart phones, there are service repositories and application stores in remote mobile clouds. Similarly, with the ceaseless advancements in the device ecosystem and in the IT field, government-specific applications will flourish and be deployed and maintained in special cloud stores, platforms, and infrastructures to be found, bound, and used by any input/output devices for a variety of everyday personal and professional purposes. Smart, sustainable, intuitive, and citizen-aware services can be dynamically created from the ground up as well as orchestrated or choreographed out of multiple atomic and discrete software services. Such composite services are directly fulfilling government activities. Thus, clouds emerge as the most common and minimum requirement for not only producing and stocking services but also for hosting application platforms. Further, clouds facilitate provisioning and renting out their configurable and customizable assets on demand. Through self-service portals, the cloud usage is to pick up fast in the days to unfold. In this chapter, the authors write about how cloud adoption is to ring in delectable transformations for worldwide governments as well as their citizens, that is, how governments can accomplish more with less, how people can experience high quality, technologysponsored digital living, how the cloud idea becomes a centre of attraction for more ingenuity towards newer and nimbler service conceptualization, concretization, and delivery.


bank, insurance company, bank insurance, financial intermediaries, integration, financial market Features of integration processes in the financial market of Ukraine on example of banks and insurance companies are displayed in the article. Approaches to integration efficiency assessment of financial intermediaries are considered. Features and development trends of insurance and banking businesses in the Ukrainian financial services market as well as prospects of their cooperation in the form of bancassurance are displayed.


Current directions in autonomous systems focus on collecting large amounts of data to verify, validate, test, and evaluate system operations. For multidomain and uncertain scenarios, data sampling may not be adequate to fully explore and represent the entire trade space for verification and validation (V&V). However, leveraging methods from test and evaluation (T&E), a hierarchy of analytics can be developed so as to narrow the trade space, while the opportunity cost of the remaining space is a risk-mitigated deployment strategy. Issues in V&V/T&E employ statistics, but could benefit from theoretical analytics, such as the ability to augment data for testing using simulated models or define tests to minimize operational risk. The use of modeling is not new; however, as analytics of artificial intelligence and machine learning (AI/ML) are designed to exploit data; then these methods are independent of the data developed from the first-principles physics models. The paper highlights the need for methods of analytical science for autonomy evaluation and presents three examples in structural, situation, and cyber awareness.


Big data, the mobile Internet, social media and the Internet of things (IOT) generate more information than ever but the aggregation of social intelligence remains far from realising it's potential. Two exemplary works, mediated_moments and plasma_flow, exhibited at Beijing's China Millennium Monument Museum of Digital Arts in 2012 model the scalable potential of urban media to weave itself into the city's social fabric, mapping and visualizing individuals' thinking/intelligence onto a mixed-reality urban canvas.


Education is one of leading sectors in the development of student character. Specifically, it aims to identify character values and integrate them into elementary school's life. Kejei dance is one of the dances in which there are character values that have a role in shaping elementary school students' character with God, themselves, others, and their nationality which expressed in every movement of the Kejei dance. The purpose of this study was to discover the meaning contained in the various basic movements of the Kejei dance in the process of shaping elementary students' character. This research belonged to qualitative research with a narrative approach. Primary data sources are taken from observing the variety of movements of the Kejei dance. In other words, the data were collected through observation and interviews. Afterwards, the data gathered were analyzed through data reduction and conclusions. The results showed that the Kejei dance contains the meaning and value of character education which is reflected in several types of movements including Sembah Menari movement, Bederap Salah Pinggang movement, Metik Jari movement, Mateak Dayung movement, Sembah Penyudo movement, and Mendayung movement. In sum, the overall meanings of the basic movements of the Kejei dance show religious values, tolerance, discipline, and communication.


Key Points Question What is the association of telehealth vs in-person encounters with outcomes of care during the COVID-19 pandemic in the US? Findings In this cohort study of 40.7 million US commercially insured adults with acute clinical conditions, those with an initial telehealth encounter, compared with an in-person encounter, had higher odds for any follow-up encounter, an emergency department encounter, and in-patient admissions. For people with chronic conditions, the odds were lower for those with an initial telehealth encounter. Meaning The contrasting patterns of follow-up care among members receiving telehealth for acute and chronic conditions have implications for health services during and after the COVID-19 pandemic.


Reparable modular system is used for packaging microelectronic flat packs and miniature discrete components. This three-dimensional compartmented structure incorporates etched phosphor bronze sheets and frames with etched wire conductors. It provides an effective heat sink for electric power dissipation in the absence of convective cooling means.


Thefrequency andspecificity ofhumancells withnatural killer (NK)cytotoxic activity forherpes simplex virus type1 (HSV-1)-infected targets was measured bylimiting dilution culture. Thefrequency ofNK cell precursors(NK-p) reactive withHSV-1-infected cells was 2-to11-fold higher thanthatofNK-preactive with mock-infected cells. Thefrequency ofNK-preactive withinfected target cells lacking viral glycoprotein C or presenting an antigenically altered glycoprotein B was approximately twofold lowerthanthatwithwild-type virus-infected cells. Specificity analysis demonstrated thatNK cells with a highstatistical probability ofbeing monoclonal were reactive witheither glycoprotein BorC.Theseresults provide thefirst evidence thatcells with humanNK activity possessclonal specificity forHSV-1-infected target cells. Humannatural killer (NK)cells lysea widevariety of targetcells without a demonstrable requirement foreither priorantigen exposure or matching betweeneffector and target cells atthemajorhistocompatibility locus (17). This distinguishes NK activity fromcytotoxicity mediated by antigen-primed T lymphocytes andledtotheassumption thatNK activity isnonspecific. However, recentstudies suggest thatcells withNK activity recognize specific structureson targetcells andmay possessclonal specificity for their targets (3,17-19, 26,29,30). Toinvestigate thespecificity ofhumanNK cells, we used targetcellsinfected withherpessimplex virustype1 (HSV-1). ThemajorHSV-1-encoded glycoproteins (gB,gC, gD,andgE)are expressed on infected cellsurface membranes, andthephysical andantigenic structure ofmany of theseproteins hasbeenatleastpartially characterized (reviewed inreferences 24andIla). Thisinformation provides an important advantage over theuse oftumortarget cells, mostofwhichhavenotbeenwellcharacterized for surface antigens. Inaddition, a numberoflaboratories have reported methodsofgenetically manipulating theseglycoproteins inways that change their ability tofunction invirus replication ortointeract withtheimmunesystem(12, 24). In previous studies, a combination ofa glycosylation inhibitor anda virusglycoprotein mutantwas usedtodemonstrate thatthepreferential lysis ofHSV-1-infected target cells by humanNK cells correlates withtheexpression ofgBandgC on target cell membranes (3)andisindependent ofinterferon production (4). Bishop etal.(5)haverecently reported that cells infected withantigenic variants ofHSV-1altered in individual epitopes ofgBorgCshowdecreased susceptibilitytoNK activity andthatmonoclonal antibodies specific forgB or gC blockNK activity against HSV-1-infected target cells. Here, we useshort-term clones ofcells withNK activity inlimiting dilution (LD)culture toexamine whether


Abstract The paper establishes the relationship between the coefficients of the closed-loop characteristic polynomial and the output feedback matrix. The conditions under which these coefficients are linear functions of the elements of feedback matrix are given. The results are used to determine the existence of stabilizing and pole assigning output feedback matrices. The maximum number of the arbitrarily assignable poles is also given.


The consumers' perception of risks in everyday life differs from experts' views and their judgement. The views on risks also differ among the consumers. So what drives the perceptions of chemical risks and how can communication be designed to address the heterogeneous concerns of different consumers? The crucial question of communication, concerning the what, how, through which channels and by whom still await systematic and scientifically valid answers. In order to gain knowledge about the communication of chemical risks and combined risks, DIA organised and conducted three focus groups, two with engineering students and one with mothers with young children. The main objectives were to demonstrate the variability of the consumers' behaviour and needs and explore the mechanisms of coping with complexity, uncertainty and ambiguity. The results confirmed the variability of answers and provided rich empirical data of which aspects should be taken into consideration when communicating chemical risks.


Exploring the Effects of Online Instructional Models on the Writing Achievement of High School Students With and Without Disabilities by Bradley Jon Kaffar Dr. Susan Miller, Examination Committee Chair Professor of Special Education University of Nevada, Las Vegas The purpose of the study was to investigate the effectiveness of three online models for teaching a paragraph writing strategy to students with and without disabilities. A learning strategist instructor implemented The Paragraph Writing Strategy (Schumaker & Lyerla, 1993) using three treatment groups that included the following online models: (a) Power Point media, (b) streaming video, and (c) multimedia (Power Point and video). Participants were 121 high school students in grades 9 through 12 enrolled in an online charter school program; there were 27 students with disabilities and 94 students without disabilities. Data were collected to answer five research questions related to the effectiveness of the three online models for teaching the strategy. Two assessments were used as preand posttest measures: The Oral and Written Language Scales (OWLS) (Cairow-Woolfolk, 1996) and a Curriculum-Based Paragraph Writing Assessment from The Paragraph Writing Strategy. The effects of the intervention were analyzed using a 3 x 2 x 2 mixed-model analysis of variance (ANOVA). To further


Abstract : This study investigates the process used within the Logistics Assistance Program to generate requirements for Field Maintenance Technicians. The complexity and lack of visibility of present procedures have called into question the validity and accuracy of current requirements. Moreover, each of the DARCOM Major Subordinate Commands has its own Field Maintenance Technician staffing pattern and requirements determination method. The major recommendations of this study are that centralized staffing guides be prepared and that technical assistance requirements be considered within the Integrated Logistics Support concept for weapon and equipment systems.


In the previous works, the authors presented the fuzzy reproducing kernel method(FRKM) for solving various boundary value problems. The nonlinear singular initial value problems including generalized Lane − Emden−type equations are investigated by combining homotopy perturbation method (HPM) and fuzzy reproducing kernel Hilbert space method (FRKHSM). He's HPM is based on the use of traditional perturbation method and homotopy technique and can reduce a nonlinear problem to some linear problems and generate a rapid convergent series solution in most cases.FRKHSM is also an analytical technique, which can overcome the difficulty at the singular point of non-homogeneous, linear singular initial value problems; especially when the singularity appears on the right-hand side of this type of equations, so it can solve powerfully linear singular initial value problems. Therefore, using advantages of these two methods, more general nonlinear singular initial value problems can be solved powerfully.Some numerical examples are presented to illustrate the strength of the method.


Introduction. The early development of the gonads of the mouse, including the differentia tion of the ovary and testis, was described by Brambell (1927) in the first part of this series, together with the subsequent development of the ovary. It was intended to describe in a subsequent paper the development of the testis from the time of its differentiation until maturity, but examination of an extensive series of embryonic testes did not yield results of sufficient importance to require publication, since the paper by Agdhur (1927), dealing with this subject, had appeared in the meantime. The present paper deals with the development of the testis from birth until long after sexual maturity is attained, and is, therefore, the logical completion of the series begun in 1927. This paper deals chiefly with the sizes of the testes and their measurable components in relation to the age and the cleaned-body weight. The results, so obtained, are correlated with the more clearly defined histological phases, but no attempt is made to describe systematically the post-natal histology or cytology of the testis. The work has been executed with a view to providing data of the normal growth of the testis in the mouse, such as Donaldson (1924) has provided for the rat, which should serve as controls for experimental work. In particular an attempt has been made to treat separately the growth of two component tissues of the testis—the spermatic tubules and the intertubular tissue. We define the " intertubular " tissue as all tissues within the tunica albuginea other than the spermatic tubules. I t therefore includes connective tissue, blood vessels, lymph-spaces, etc., as well as the so-called " interstitial " cells. It was found impossible to measure accurately the amount of interstitial cells present.


ERH end quenching method was used to determine the hardenability of four kinds hot forging die steels with deep hardening and hence the order of their hardenability was given. The tempering hardness of the steels was measured and the tempering resistance was studied. It was approved that ERH method is effective for the determination of hardenability of deep hardening steel and the beginning of hardness drop in the ERH specimen is caused by bainite occurring.


This study investigated whether equating accuracy improves with an anchor test that is more representative of its corresponding total test and whether such content effect depends on the particular equating method used. Scoring outcomes of a professional examination for a medical specialty were used. A total of 1,092 examinees took one form, and 1,149 took the other form. Item-sampling schemes were introduced to manipulate the content homogeneity and representation of anchor items so that their effects on equating accuracy could be studied with varied equating methods. Multiple criteria were proposed to evaluate equating accuracy. Overall, the study found that all the equating methods employed had accurate results to a moderate degree. They all produced more accurate results when the anchor items were more representative of their total test or when the content coverage of a test concentrated on fewer topics. In general, Item Response Theory-based equating was found to be more accurate than classical equating, but the small differences may not be substantial. To produce equating outcomes that are precise and less prone to bias, various equating methods should be considered for equating test forms for high-stakes examinations. (Contains 4 tables, 3 figures, and 22 references.) (SLD) Reproductions supplied by EDRS are the best that can be made from the original document. The Effects of Content Homogeneity and Equating Method On the Accuracy of Common-Item Test Equating


Date: May 29 th 2013 Title: Development of an investment decision model – for smaller service companies University: Mälardalen University Institute: School of Business, Society and Engineering Subject: Master thesis in Business Administration, 15 credits Authors: Elena Hallin Rimon Khames January 17 th 1989 September 18 th 1989 Tutor: Leif Carlsson


We extend Fox, Kohli, and Warren (2002) by using alternative techniques to re‐examine the sources of New Zealand's macroeconomic performance during the period 1983–2001. Specifically, a modified Diewert‐Morrison decomposition is used to quantify the separate contributions from productivity growth and changes in factor utilization, the terms of trade and the trade balance to GDP growth. We also use a new Fisher‐index decomposition to analyze the determinants of GDP growth. These techniques are adapted to identify sources of deviations of GDP from its trend. The results of these decompositions reveal that changes in domestic prices accounted for three‐fifths of the growth of nominal GDP over the entire sample period. Capital accumulation and employment growth were wholly responsible for the real‐output growth in this time frame. However, changes in total‐factor productivity or in the terms of trade contributed importantly to changes in real net output and in an index of aggregate welfare in specific years. Finally, no one factor was primarily responsible for explaining changes in the nominal (or real) output gap over the whole period.


The West Nile Virus (WNV), a mosquito-borne Flavivirus is a common infection identified in the Middle East, Europe, West Asia, Africa, Australia and the United States. The virus can cause severe illnesses and death in horses. The current study aimed to screen West Nile virus neutralizing antibodies in Arabian horse populations from breeding farms located in Central, Eastern Anatolia and Marmara by plaque reduction neutralization test (PRNT). We sampled 165 Arabian racehorses, during March-December, 2010, in three different provinces (Eskisehir, Malatya, and Bursa) in Turkey. Screening of serum samples showed that 6.6% were positive for West Nile (WN) virus-neutralizing antibodies. The obtained data demonstrate WNV is circulating in mentioned regions among racehorses and the need to carry out a surveillance program includes WNV-focused screening tests in Turkey.


A spectrophotometric method for the determination of nano size Al 2O 3 in four kinds of electroplating solution is reported in this paper. It is shown that a wide wavelength inteval in which a low absorbance of blank and high absorbance of the testing solution is existed. All correlation coefficients of the standardized curves are greater than 0.98 and the average relative error (2.93%) of the present method is much less than that of the gravimetry (20.7%).


Article represents the flame resistance and the heat resistance of poly (phenylene ether) is prepared from a composition comprising the polysiloxane block copolymer reaction product, flame retardants, and reinforcing filler in a specific amount. The article to get the benefit from the properties of the composition, the electrical diagnostic copier (electrophotographic copier) fuser holder (fuser holder), a fan blade, a hybrid vehicle and electric vehicle battery parts, auto kinetic energy recovery system (automotive kinetic energy recovery for there is such system) parts and junction boxes for electric cars.


New China was founded more than 50 years ago. Great changes have taken place. The development of population has experienced "without plan" and "planned" stages. It shows that the chinese nation has experienced the important process from passive way to active way in the important issue of solving the development of population. The awareness has become mature. Fact shows, especially after the reform and opening to the outside world, earth-shaking changes in politics, economy, culture and education, hygiene and social environment, planned development of population is the basic strategy for wealthy nation and strong people.


A data field editor on whole screen is constructed with C language in this paper.Based on it,A input screen with style of Foxbase+is constructed,charatered of color fields,changing cuesor,online help and data valide.


A redesign of the joint-replacement program [4] by the University of Florida College of Medicine's Department of Orthopaedics and Rehabilitation, however, managed to lower costs while shortening hospital stays and reducing both readmissions and complications, according to a new UF Health study published in the journal Arthroplasty Today. Additionally, pain management and mobility after surgery were dramatically improved, allowing patients to recover at home instead of at rehabilitation facilities, the study said.


Hobbes' and Gassendi's friendship and intellectual affinity constitute a tight thread hard to be untied. Beyond clearly defined convergent views such as the common aversion to Cartesian dualism and innatism and clear divergences in their specific philosophical orientations, the meaning of their often similar trajectories must be precisely clarified. The privileged context for a comparison between them is doubtless the construction of a psychology deeply influenced by empirical premises and whose aim is to establish a close relation between the processes of perception, desire (appetitus) and will on the one hand and their mechanical and material causes on the other. One can claim that Gassendi's works written in the beginning of the 1640s introduce a number of new hypothesis on the bases of which emerge a certain convergence with Hobbes' views developed in the same occasion. The texts written during the years 1640-41 where Gassendi inquires on the nature of light are emblematic. A number of aspects of Gassendi's inquiry can be easily confronted with Hobbes' writings: his explanation of the behavior of luminous bodies in terms of systole and diastole; his interpretation of the propagation of light, which is inspired-in a explicit and open polemical fashion against Descartes's thesis in his Dioptics about luminosity as nothing but inclination to movement-by the plain cinematic actuality; his belief in the existence of the void, which is peculiar to Gassendi, making possible the explanation of the phenomena of expansion and contraction of luminous sources (a view which was not at the occasion excluded by Hobbes); and finally, the material and mechanical representation of the phenomena of irradiation.


Ludmerer, Kenneth M. Learning to Heal: The Development of American Medical Education. New York: Basic Books, 1985. xv + 346 pp. $21.95 cloth. Morantz‐Sanchez, Regina Markell. Sympathy and Science: Women Physicians in American Medicine. New York: Oxford University Press, 1985. xii + 464 pp. $24.95 cloth. Porter, Roy, ed. Patients and Practitioners: Lay Perceptions of Medicine in Pre‐Industrial Society. Cambridge: Cambridge University Press, 1985. 356 pp. $49.50 cloth.


This paper took the listed companies as samples and discussed closely around the executive subject of the internal control—CEO. On the basis of distinguishing the CEO's degree education and professional title education, this paper fully discussed the influence of CEO's education level on the effectiveness of internal control of enterprise. This study found that the CEO's high degree education and high professional title education level are greatly helpful to improve the effectiveness of the internal control, and the further study also shows that the CEO's "double high" education level also helps to enhance the level of internal control effectiveness. This study inspired us that the enterprise internal control behaviors need to embed its CEO's education background, meanwhile, it also provides a guidance for the scientific implement of human resources management and especially provides a reference for the CEO selection. KEYWORD: degree education; professional title education; the effectiveness of internal control; scientific management


There is provided a method for manufacturing a reverse blocking insulated gate bipolar transistor, which in the manufacture of a reverse blocking IGBT having a release layer which is formed along tapered surfaces of a V-shaped groove is formed using anisotropic etching, a high- can ensure reliable inverse pressure resistance and suppress a leakage current in the reverse-bias. Upon irradiation with a flash lamp for a flash lamp annealing after implantation of ions into a second type of conductivity separator layer and a second type of conductivity-type collector layer to form the second type of conductivity-type collector layer and the second type of conductivity-separating layer of the strongest portion of the radiation energy to a depth position from the upper portion focused to the middle portion of a tapered side edge surface.


Interest in negative symptoms has increased in recent years (cf. Strauss 1985; Pogue-Geile and Zubin 1988), as evidenced by a great number of theoretical as well as empirical papers dealing either with the investigation of negative symptoms or applying them as moderator variables in researching various questions. This interest in negative symptoms and their differentiation from positive ones is connected in particular with the hope of identifying factors with different prognostic, therapeutic and pathogenetic significance (Crow 1989). Research involves prediction of the course of illness (particularly long-term; Pogue-Geile and Harrow 1985; Strauss et al. 1989: psychological and social influence of negative symptoms on the course) and the response to therapy (Andreasen 1982). Particularly fascinating are the aetiological questions (cf. also Zubin 1985) in the sense of covariation with structural brain changes, neurochemical, neurophysiological or genetic features (Crow 1985). Origins of the concept can already be found in the nineteenth century (Berrios 1985), although no uniform theory is discern able up to the present time (Sass 1989). The definitions are broad to varying extents (Crow 1985) and are, thus, also associated in part with a number of other concepts or are even uses synonymously with them (e.g. acute vs. chronic, plus vs. minus; cf. Sass 1989). In the latter case, however, specific implications are usually additionally connected to them (e.g. residual symptoms: chronicity, course, onset and domain of function; Sommers 1985). Many definitions of negative symptoms share the absence of or the inadequate development of normal functions (e.g. Sommers 1985; Grossman et al. 1989; Zubin 1985). According to Lenzenweger et al. (1989, p. 62), one can differentiate between positive and negative symptoms as follows:


Situs inversus totalis is a rare congenital condition present in approximately 0.01% of the population in which the major visceral organs are reversed from their normal position and can pose difficulties in the diagnosis and management of acute abdominal pathology. Symptomatic cholelithiasis is very common in India and laparoscopic cholecystectomy is the gold standard treatment at present. Laparoscopic surgery in a situation of situs inversus is challenging due to the mirror-image anatomy. Diagnostic pitfalls and technical details of the laparoscopic cholecystectomy are discussed.


The AMPTE/IRM plasma and magnetic field data show that the compression in the central plasma sheet ( 20 R{sub E}) or the plasma sheet boundary layer where fewer particles are likely to escape from a flux tube through the loss cone to meet the particle conservation requirement of the adiabatic condition.


The use of cement has been one of the longest-lasting and most contentious issues over the history of modern THA surgery. Initially advocated by Sir John Charnley, it was later condemned by eminent researchers, as it was thought to be the cause of fixation failures and osteolysis [4]. In the 1990s, a variety of cementless (mainly porous-coated) femoral components were introduced and embraced by the majority of US surgeons. At the same time, cemented femoral fixation continued to be favored outside the United States in places like Great Britain and the Nordic countries, leading to a "North Atlantic Divide", which persisted until the mid-2000s [1]. A turning point emerged around the mid-2000s toward increasing use of cementless femoral fixation in Europe. A study on national registry data from seven countries revealed the greatest absolute increases were recorded in England, Wales, and Denmark [16]. Although historically advocated mainly for younger patients [4], cementless fixation had been increasing in the elderly, despite cemented THA being associated with lower revision rates [16]. The current work by Tanzer and colleagues [13] draws data from the Australian Joint Replacement Registry to further examine this "uncemented paradox" [16], focusing on the femoral side and on patients older than 75 years of age. In their study, the authors reduced residual confounding by comparing the survivorship of only the best three cementless and cemented stems and by limiting the bearing surface used to crosslinked polyethylene. They demonstrated that patients receiving a cementless implant were, overall, more likely to undergo a revision for fracture and loosening during the first 3 postoperative months. This difference was most pronounced in patients treated for femoral neck fracture, for whom dislocation was an additional cause of early revision. At final followup, however, the two types of stems performed equally well. This work conveys an important message about the practice patterns employed in THA surgery, one of the most common procedures in orthopaedics [6]. By joining forces with voices of the recent past [1, 9, 15, 16], the current study shows that cementless femoral fixation in older patients may be less innocuous than generally thought. On the other hand, the authors correctly noted that their findings applied to only the first few months after implantation. This is in contrast to previous registry research demonstrating an inferior performance of cementless stems in the older age groups in the long-term [16]. Clearly, there is room for further investigation in this subject.


According to the technical specifications of the plate used for submerged pipeline in south sea,the 31.8mm thickness X70 hot-rolled plate used for submerged pipeline were developed by reasonable composition design and optimized slab size,reheating schedule,controlled rolling and controlled cooling process.The main microstructure of the plate with high strength and good anti-crack toughness at low temperature consist of uniform fine acicular ferrite and a small number of M-A island so that the plate can meet the technical requirements of submerged pipeline in south sea.


This study examines how related-party transactions (RPTs) and related disclosures are valued by investors. Due to the significance and manipulative nature of RPTs, a transparent disclosure of RPTs is important and relevant for investors and policymakers to properly infer firm value from accounting disclosures. However, full disclosure of RPTs may not be cost effective because not all information that firms possess is of value relevance to the users of financial statements. Using a sample of 3,092 firm-year observations of Chinese listed companies that have RPTs during the period of 2007-2012, we first assess the value relevance of RPTs by estimating the return-earnings associations. We use OLS regressions and regress related-party sales, transfer pricing methods and nonrelated-party sales against abnormal return of a firm. As hypothesized, we find that the mere disclosure of amounts transacted with related-parties does not provide additional relevant information over and beyond the total sales amounts. However, the disclosure of the transfer pricing methods does provide value-relevant information, and this additional disclosure improves the R-square of the regression model by 6.2 percent. We also find that the transfer pricing disclosures are value-relevant for firms with weak corporate governance but not for those with strong corporate governance. Overall, our findings demonstrate the usefulness of more transparent and detailed disclosures of RPTs in inferring firm value.


The purpose of this paper was to examine the influence of management support on success of ERP implementation in KSC. The study used 35 respondents who were randomly selected based on the 10-30% rule of Mugenda and Mugenda (2004). A semi-structured questionnaire was used to collect the data. Data analysis was both qualitative and quantitative. The paper concludes that management had not been very supportive of ERP Implementation and that that management didn't pay due attention to problems that rose during ERP implementation and that top management didn't prioritize/emphasize ERP implementation.


We explore the idea of tagging people for selective information sharing in the context of a social-personal information management (SPIM) system. Each new tag applied to a person has a distinctly specifiable visibility, and people tagged with the same key word form a relationship group that can be used as an access control option for each piece of information. We introduce the idea and motivation behind people-tagging, describe a research implementation we have created to experiment with the concept, and provide a preliminary discussion of potential usage and directions for future work.


A code U initiative starting in the FY04 budget includes specific funding for 'Phase Change' and 'Multiphase Flow Research' on the ISS. NASA GRC developed a concept for two facilities based on funding/schedule constraints: 1) Two Phase Flow Facility (TphiFFy) which assumes integrating into FIR; 2) Contact Line Dynamics Experiment Facility (CLiDE) which assumes integration into MSG. Each facility will accommodate multiple experiments conducted by NRA selected PIs with an overall goal of enabling specific NASA strategic objectives. There may also be a significant ground-based component.


Chinese leymus(Leymus chinensis),is a strategic plant resource for both technological advantage in China and for many useful gene resources.Our objectives were to establish the technical base for the study of molecular biology of Chinese leymus.The differentially expressed genes of calli from different immature inflorescences of genotype W4 were studied.These calli displayed differences in plant regeneration.Differential cDNA fragments were isolated by means of DDRT-PCR analysis and silver-nitrate staining.The differential fragments were cloned and sequenced.Nucleotide sequence analysis of these two cDNA fragments showed that they were homologous to the genes encoding translation factor eEF-1 of glutathione S-transferase,respectively.


Why was the Black Death followed by the decline of serfdom in Western Europe but its' intensi…cation in Eastern Europe? What explains why involvement in Atlantic trade in the Early Modern period was positively correlated with economic growth in Britain but negatively correlated in Spain? Why did frontier expansion in the 19th Century Americas go along with economic growth in the United States and economic decline in Latin America? Why do natural resource booms seem to stimulate growth in some countries, but lead to a 'curse'in others, and why does foreign aid sometimes seem to encourage, other times impede economic growth? In this paper we argue that the response of economies to shocks or innovations in economic opportunities depends on the nature of institutions. When institutions are


Historically, solving optimal control problems with high index differential algebraic equations (DAEs) has been considered extremely hard. Computational experience with Runge-Kutta (RK) methods confirms the difficulties. High index DAE problems occur quite naturally in many practical engineering applications. Over the last two decades, a vast number of real-world problems have been solved routinely using pseudospectral (PS) optimal control techniques. In view of this, we solve a "provably hard," index-three problem using the PS method implemented in DIDO, a state-of-the-art MATLAB optimal control toolbox. In contrast to RK-type solution techniques, no laborious index-reduction process was used to generate the PS solution. The PS solution is independently verified and validated using standard industry practices. It turns out that proper PS methods can indeed be used to "directly" solve high index DAE optimal control problems. In view of this, it is proposed that a new theory of difficulty for DAEs be put forth.


The system of technical operation (TO) of on-board equipment or avionics of aircraft (AC) as an object of research is a set of objects and means of technical operation, maintenance and repair programs, as well as personnel performing procedures and organizing the processes of TO. The quality of the TO system is manifested in the TO process - a set of processes of intended use, operational control, maintenance, restoration and repair. The TO process, as a process of changing the TO states, can be considered as a controlled random process, determined on the set of operation states by probabilistic characteristics. The quality of the TO system is characterized by a set of properties that determine its ability to satisfy with the maximum economic efficiency the needs of the TO system of the aircraft, while ensuring the required levels of reliability and readiness of the avionics for operation. That is, the TO system has all the features inherent in complex technical systems - a hierarchical ramified structure, subordination of goals and restrictions, wide interrelationships in the process of functioning. The main research apparatus in solving problems of optimization of processes and synthesis of TO systems is the apparatus of the theory of mathematical modeling of complex technical systems, based on a system approach, the integration of analytical and simulation modeling. The article solves the problem of determining the values of the parameters of the TO system such that the costs of the system during the TO process reach a minimum when all the required tasks are completed and all restrictions on the system's own parameters and indicators of its technical efficiency are met.


For the explosive dispersal on liquid fuel of FAE technique, the expansion of gaseous detonation products, axisymmetric radial extension and fragmentation of a liquid ring were analyzed, then corresponding models were established. By those models coupled, the numerical simulation on motion and fragmentation of the liquid ring exerted by strong action was carried out. The results computed show that the models established are feasible, and present study can offer initial conditions for the numerical simulation on the process of liquid secondary breakup and gas-liquid mixing.


In this article,the author discusses the new method of geographic data management system.It includes the purpose,structure and function of data management system,at the same time,the author also talks about its application in producing management.


We calculate radiative energy loss of heavy and light quarks in an anisotropic medium (static) in a first-order opacity expansion. Such an anisotropy can result from the initial rapid longitudinal expansion of the matter created in relativistic heavy-ion collisions. Significant dependency of the energy loss on the anisotropy parameter {xi} and the direction of propagation of the partons with respect to the anisotropy axis is found. It is shown that the introduction of early-time momentum-space anisotropy can enhance the fractional energy loss in the direction of the anisotropy, whereas it decreases when the parton propagates perpendicular to the direction of the anisotropy.


Title

A Puzzling Headache : Cerebral Venous Thrombosis

First Author

Dr Tan Siang Tai

Institution

Emergency and Trauma Department, Hospital Sultanah Bahiyah, Alor Setar, Kedah

Other Authors

Dr Muhamad Faiz Bin Mohd Fauzi, Dr Cheng Hee Song, Dr Fatahul Laham B Mohamed

E-mail Address

firstname.lastname@example.com

Introduction

Cerebral venous thrombosis (CVT) refers to local clot formation and occlusion of intracranial venous structures. CVT is an uncommon form of stroke and usually affects young individual.

Case presentation

We present a case of 24-year-old gentleman who visited to our Emergency Department after developed acute left sided body weakness and numbness with one-month history of chronic right sided pulsating headache. Physical examination revealed a well oriented male in mild distress with normal vital signs. Motor system examination revealed reduced power over left upper and lower limbs. Otherwise, other neurological examination findings were unremarkable. CECT brain was performed immediately and demonstrated increased density over superior sagittal sinus, right transverse sinus and right sigmoid sinus together with filling defects seen within right transverse sinus and right sigmoid sinus suggestive of cerebral venous thrombosis. Subsequent MRV confirmed CT findings and showed new thrombosis of the right transverse sinus, right sigmoid sinus and superior sagittal sinus. Patient was then started on anticoagulant and discharged well from the hospital subsequently.

Discussion

The diagnosis of CVT is often difficult especially in young male adult and can lead to a delay in treatment. Despite of non-specific and varied symptomatology, headache has been reported as the commonest complaint in young patients. CT brain is the most commonly performed imaging in emergency room. Non-contrast CT findings can be subtle depending on the hyperdensity of the sinus being identified. With contrast administration, computed tomography may show the classic "delta sign".

Conclusion

This case highlights the importance of keeping CVT in the differential diagnosis when treating a young adult for ongoing headaches. Ability of doctors working in emergency department to detect the aforementioned specific CT brain findings definitely help to shorten the turnaround time for diagnosing CVT in adults in Emergency Department.


Yield test of 41 entries, 32 new hybrids, 8 male parents restore lines and 1 inbred variety,
was conducted on the farm of University of Arkansas at Pine Bluff (UAPB) in
2012. The only inbred Francis in this experiment was used as the check. Francis is a
popular variety and widely used in Arkansas rice production. Results showed that the
yields of 7 hybrids were 25.7% - 30.7% higher than check Francis. Hybrid 28s/BP23R
had the highest yield, 10846.6 kg/hectare and over check by 30.7%. The yield of hybrid
28s/PB-24, was 10628.9 kg/hectare and over check by 28.1%. The yields of hybrid
28s/PB-22 and 33A/PB24 were 10549.8 and 10539.8 kg/hectare and over check
by 27.1% and 27.0%, respectively. The sterile lines 28s, 29s, 30s and 33A have good
combinability. PB2, PB5, PB12, PB22, PB23, PB24, and PB25 are good restorers and
most of their hybrids were over check more than 17%. Sterile 28s has DEMG (Dominant
Early Maturity Gene) which can make earlier heading hybrids by crossing
with late restorer lines. Sterile 30s and 33A have no DEMG but have heat resistant
gene. They can make late heading hybrids by crossing with late restorer lines PB24
and PB22 and the late heading hybrids can resistant to hot temperature. These results
showed that these sterile lines, restorer lines and hybrids can be used in rice production
of Arkansas in the future.