China has been experiencing rapid urbanization in the past three decades and more and more urban clusters are emerging. In concomitant with the urban heat island (UHI) effect, the upstream urbanization may exert impact on the microclimate of the downwind city. In particular, under extreme weather conditions such as heat waves, the upstream impact together can exacerbate the local UHI effect. This study investigates the impacts of upstream urbanization on the UHI effects of downwind cities by conducting numeric simulations in Yangtze River Delta Region under a heat wave of 2013 with Weather Research Forecasting (WRF) model coupled with an improved single-layer urban canopy model (UCM). The simulations are first performed under three representative urbanization scenarios to assess the sprawling effect of upstream megacity (Hangzhou) on the downwind city (Haining), whose results indicating a mean 0.65 degreesC (0.24 degreesC) increase of nighttime (daytime) surface air temperature in Haining caused by the urban expansion of Hangzhou with a doubled built-up area. In addition, the downwind effectiveness of mitigation in upstream megacity is examined by enabling the green roof option in WRF-UCM system. It is found a green roof coverage of 50% in Hangzhou can reduce the daytime near surface temperature in Hangzhou by around 0.15 degreesC. This study reveals the synergies of cities within an urban cluster in modifying urban microclimate and highlights the effectiveness of green roofs.


It is essential to develop the urban tourism for urban economic,social and ecological.Tourism image is one of the key factors to attract tourists,so the construction of perfect urban tourism image is very important.This paper analyzes the current situation of Tangshan city tourism image,and put forward recommendations on constructing the image of the tourist of Tangshan.


Effects of the worst crisis since the Great Depression are still being felt throughout the world. While emerging economies have found their way out, due to sound economic fundamentals, developed economies are still struggling. The crisis unfortunately proved the damages caused to real economy by a non-regulated global, interconnected financial system. This article aims assessing the performance of recent regulation measures and provides additional regulation paths enabling financial stability. The first section briefly summarizes the factors having allowed the development of the current financial and economic crisis. The second section analyses the links between financial markets and real economy, both in developing countries and in advanced economies. The third section addresses the necessity to regulate the financial system. The forth section assesses the effectiveness of existing regulation policies, particularly the Basel III Recommendations and the Dodd-Frank Act, in the US. The fifth section proposes different regulation solutions and concludes.


We present experimental measurements of L-shell production cross sections Lα, Lβ and Lγ for tantalum and thulium by electron impact at incident electron energies from about one to three times the threshold energy. From the experimental data, the total production cross section and mean ionization cross section are deduced. The influence of electrons reflected from the substrate is corrected by the electron transport bipartition model. The measured cross sections are compared with the theoretical predictions.


EGNOS is the European SBAS currently providing GPS Safety of Life augmentation over Europe. In parallel with on-going EGNOS operations, GNSS constellations and signals are evolving (GLONASS, GPS, GALILEO, COMPASS, ...). This evolving context has led ESA to launch the so-called "European GNSS Evolution Program" (EGEP) in order to explore more in depth the various evolution perspectives and evaluate possible opportunities. This program has notably led to the development of a complete Test Bed environment called SPEED - Support Platform for EGNOS Evolutions & Demonstrations. SPEED has been developed as the natural successor of ESTB (EGNOS System Test Bed) both for rationalizing EGNOS releases qualification and for performing innovative SBAS experimentations and demonstrations. SPEED is fully representative of EGNOS when fitted with EGNOS operational algorithms. It is also designed for SBAS experimentations thanks to its flexibility, allowing adjusting the platform to the users' needs. It allows easy algorithms update and tuning during experimentations phases. SPEED has a "Fast Replay" capability allowing processing a one-week data scenario in a single day. The first SPEED practical use case is the High Integrity Test Bed (HISTB) experimentations. The main objective of these experimentations is to provide technical elements allowing to determine if the EGNOS V3 foreseen new features targeted for aeronautical users are feasible and of interest. Experiments are thus performed on the following areas, which are currently considered in EGNOS V3 definition: · Multi Frequency evolution, to offer not only legacy aeronautical service (to mono-frequency SBAS L1 user) but also a dual-frequency L1/L5 augmentation service. · Multi Constellation evolution, to provide augmentation data not only with respect to GPS constellation but also to Galileo. · Extension of the service area, in particular to cover Africa. · Areas of improvement on top of EGNOS V2 system, (functional allocation between ground monitoring stations and central processing facility, MT28 versus MT27 ...).


In LTE cellular networks, the pathloss impacts the performance of the uplink channel power control. Therefore, power control algorithms can achieve good performance on the location where user equipment (UE) is not power limited. The baseline parameter setting of the fractional pathloss power control is valid for some scenarios, however, it is a challenging issue to improve the cell edge throughput in the complex environment, especially the mix of indoor and outdoor UE scenario. This paper proposes a novel interference based power control mechanism. The key is to estimate the interference generated by UEs to other cells. Simulation results show that the proposed mechanism can effectively improve the throughput for UEs with high pathloss. In addition, the proposed mechanism can also reduce the interference from other UEs with low pathloss.


Eight heterotrophic aerobic bacteria were identified in samples from Toronto Harbour. The three tubificid species present seem to ingest most if not all of these, but different species survive passage through the gut. One of the three worm species absorbs amino acid from solution in the absence of bacteria in the gut. It is suggested that the results indicate differences in the utilization of the potential nutritional resources by the worms, which may be reflected in the ability of three unspecialized sediment feeders to coexist in the same microhabitat.


Provided are: an infrared-light shielding composition having excellent drying resistance and excellent flat application properties, whereby an infrared-light cutoff filter can be formed in which the occurrence of a pattern on the surface thereof is suppressed; an infrared-light cutoff filter; and a solid-state imaging element. This infrared-light shielding composition includes at least metal-containing tungsten oxide particles, a resin binder, a solvent A having a boiling point of 170°C to 200°C at 1 atmosphere, and a solvent B different from the solvent A, the content of the solvent A being 0.1-20% by mass with respect to the total mass of the infrared-light shielding composition.


Our project aimed to provide a mobility system for E-bikes to make urban mobility affordable and non-pollutable thus providing service through the secure mode of transportation for the urbanites and in closed environments like universities and IT parks. A fingerprint-based biometric system of authentication for E-bikes to enhance micro-mobility among the targeted audiences. Compared to other systems of authentication, fingerprintbased authentication is unique, highly accurate and an economical technique. An account can be created using personnel data and unique ID will be assigned to each individual's fingerprint. By database management system, the user can be identified, tracked and the user can also check his account and the amount for the usage-based on time is deduced from the account in the form of minutes. The web-based application notifies regarding account recharge which shows minutes. The security of the system is ensured via GPS and GSM. GPS based security ensures the vehicle becomes inoperable outside the area formulated by the service provider. This sends the system information to the web-based mobile application. This project encourages the urbanities to use E-bikes to commute affordable and eco-friendly.


was impossible-without an anaesthetiq. There was dullness on percussion over the flanks, and I detected free fluid inl *ese regions by what I call the " staccato touch."' To carry out this test the flank is struck lightly and sharply in a staccato fashion with the tip of the finger; if free fluid be present, the sound given out by percussed fluid is distinctly heard. There was no localized pallor of the external genitals, a physical sign which, when prpsent, I have found of great value in the diagnosis of atypical cases of ruptured ectopic gestatioir. Operation (September 9th, 1915).-There was a yellow discharge from the cervical canal, and on curettage I could detect no evidence of -a decidua, only the "slimy" sensation of chronic endometritis being conveyed through the curette. I therefore ruled out ruptured ectoic gestation, but on opening the abdomen the cavity was found to be full of bright red fluid blood, and the case appeared to be clearly one of recently ruptured ectopic gestation. On freeing and drawing up the adherent left Fallopian tube (enlarged tothe size of a finger), pus was seeni to be issuing from its outer end. The involved tissues were so friable that the distal portion of the tube came away quite easily in my hand up to about an inchfrom the uterine cornii. The right tabe was also much inflamed, so that double salpingectomy was carried out. Neither in the tubes nor in the ovaries was there the slightest evidence suggestive of ectopic gestation, nor could I discover any ruptured large vessel which might account for the flooding of the peritoneal cavity with blood. When the blood had been mopped out from the abdomen very acute peritonitis was revealed, the intestines being intensely red, roughened, and marked with patches of vellowish lympb. The abdominal walls were unusually lax, so that by lifting them up we wvere enabled to bring the intestines into view right up to the costal margin. As far as we could see them, the intestines were involved in exactly the same manner as under the abdomninal incision. The state of the patient now demanded prompt coniclusion of the operation, so that the kidney pouches had to be left without special cleansing, but there was no more obvious free blood. No drainage was used.


Instances of discrimination against union members continue to accumulate in France, as can be seen by the multiplication of legal proceedings and judgements against a number of large firms. This qualitative impression was underpinned by the statistical results from the 2004 French

 REPONSE

 (Relations professionnelles et negociations d'entreprise)

  survey (the equivalent of the British

 Workplace Employment Relations Survey

 ), revealing that, at the same age and education, union representatives are paid around 10% less than their colleagues. We here confirm this result in the 2010 wave of the same survey. Union membership does not suffice to explain these lower wages: it is rather shop stewards, who are the most active in the defence of workers' interests, who are the most heavily penalised. It is in practice difficult to establish that these workers receive lower wages for reasons other than their union responsibilities. The wage gap for union members who are not representatives is much smaller, at around 4%, while it is in firms that experience conflictual labour relations that shop stewards are paid the least.


Objective This paper introduces an upgrading of ADS programs aimed at improving the image post-processing speed,increase the host storage space.Methods We updated the ULTRE10 to BLADE150,and editted the host ID of the BLADE150.So now we can install the application software to the BLADE150.Results Use this methods we can greatly enhance the performance of devices,improve image processing speed,expanded image storage space,reducing patient waiting time and improve the efficiency of the hospital.Conclusion The equipment has stably run 2 years after upgrading.This method should be popularized.


The surface of ceramic friction component was copper plated chemically to improve the combination situation between ceramic phase and matrix of the copper-based powder metallurgy friction materials,thus the friction and wear properties of the materials were improved.Cu-plated Al2O3 particles and non-Cu-plated Al2O3 particles were adopted respectively,friction and wear specimens of Al2O3-Fe-Sn-C/Cu were fabricated by mixing,pressing and pressure sintering with copper powder,iron powder and so on.The microstructures,mechanical properties,friction and wear properties of friction materials were measured and analyzed.Results show that the copper-plating of friction components makes the combination between hard particles and copper matrix tight.The Brinell hardness of friction material is improved by 12%,the elastic modulus is improved by about 7%,the friction coefficient is increased by 5%-10%,and the linear wear loss is reduced by 20%-50%.In addition,Al2O3 particles plated with copper on the surface are difficult to fall off,and the friction coefficient stability is increased by 13%-23%.Therefore,the overall performance of the materials can be improved by copper-plating on the surface of friction component.


Digital elevation data are now commonly used to map channel networks automatically. This paper evaluates the sensitivity of six methods of extracting channel networks from digital elevation models (DEMs) to elevation error. As such, the robustness of channel mapping techniques against noisy data was evaluated and not the accuracy of DEM extracted channel networks. Stochastic simulations were used in combination with a fine‐resolution LiDAR DEM of a small upland catchment to assess the robustness of each of the channel mapping algorithms. Findings showed that the four tested methods that were based on identifying patterns or positions in the surface morphology were more sensitive to elevation error than the two methods that were based on simulating overland flow and channelization processes, particularly at lower error magnitudes. While the morphology‐based channel‐mapping methods were highly sensitive to the degree of spatial autocorrelation in elevation error fields, the channelization based methods were relatively insensitive. Drainage network extent and the geometry of exterior stream channels were both found to be greatly influenced by low to moderate degrees of topographic error. Although LiDAR data were found to provide a sufficient resolution for mapping fine‐scale headwater channels, the greater surface roughness did present challenges for automated channel‐mapping techniques.


A mighty Spirit came Lately upon abundance of our people, to reform their singing which was degenerated in our Assemblies, which made a Jar in the ears of the more curious and skilful singers. . . . But who would beleeve it? Tho' in the more polite City of Boston, this Design mett with a General Acceptance, in the Countrey, where they have more of the Rustick, some Numbers of Elder and Angry people bore zelous Testimonies against these wicked Innovations, and this bringing in of Popery.


Curcumin, a yellow pigment, which is a bioactive compound in Turmeric, is a polyphenol derivative used as an herbal medicine to treat remedies Coronavirus disease-2019 (COVID-19) is caused due to coronavirus which is an infectious and dangerous virus Coronavirus causes severe infections in humans and also in different species of animals Curcumin has multi properties in which one of them is anti-viral, which may help in the prevention and treatment of COVID-19 Curcumin can be taken by the means of food and studies show that there are no side effects, caused due to its consumption Turmeric is the main source of Curcumin;RDA of Curcumin is 3mg/kg/day Some of its properties include: anti-viral, anti-inflammatory, anti-bacterial, anti-parasitic, anti-tumor, anti-microbial activities It also has the ability to gene transcription the viral strains like coronavirus, and maybe a possible treatment in treating COVID-19 Curcumin as exhibits anti-viral properties and acts on viral strains for gene transcription, can be a possible treatment in prevention and treating COVID-19 © 2020, Institute of Medico-Legal Publications All rights reserved


Objectives: The purpose of this study is identify typology of candida species from patients' samples, and determine their in- vitro antifungal susceptibility. Materials and methods: In this study, Candida species isolated from patients who applied to our laboratory between 2009- 2010 were included in order to identify the types of Candida and to carry out their antifungal sensitivity. The Candida species were typed using germ tube test, corn meal Tween-80 and BBL CHROMagar medium, and API ID32C yeast identification system. Antifungal drugs' susceptibility of Candida species for amphotericin B, fluconazole, itraconazole, and voriconazole were conducted through microdilution system. Results: Of the 97 Candida species, 58.76% were identified as Candida albicans, other identified types were as follows: C. parapsilosis (13.4%), C. glabrata (11.3%), C. tropicalis (5.15%) respectively. Antifungal drugs sensitivity tests results revealed 1.03% resistance to fluconazole and 4.12% to itracanazole, whereas no resistance was found to amphotericin B and voriconazole. Conclusion: Target population for Candida has gradually been expanding. Therefore, it may be suggested that determining the type of pathogen and running its susceptibility tests are significant factors that will enhance the success of the treatment before empi- rical treatment against Candida infections is initiated.


We present a family of flow-dependent balance conditions for variational data assimilation (VAR). In the context of shallow water theory, the conditions are based upon using either relative vorticity or potential vorticity as the balanced variable, and incorporate both rotational and divergent components of the horizontal wind field. From this wind field we obtain a balanced height field, which can be used as a control variable in VAR. The balance conditions are defined using nonlinear Monge Ampère equations, which are required to be elliptic. A linear, incremental scheme is derived, and the ellipticity criterion becomes a condition on the linearization state. The schemes are tested using Rossby-Haurwitz waves for a range of Burger numbers, thereby enabling flow-dependency to be analyzed.


COMMUNICATIONS OF THE ACM May 2000/Vol. 43, No. 5 5 COMING NEXT MONTH: A special section on systems integration, particularly its role in e-commerce, healthcare, data warehousing, and digital libraries. Also, articles on telemedicine, Internet marketing, multimedia distribution, and wireless networking issues. THIS month's special section uncovers some of the most amazing technologies you'll never see. That's because they'll be embedded everywhere and in pretty much everything. "Embedding the Internet" presents a kaleidoscope of ubiquitous devices and appliances with sensing and communications capabilities to distribute computational power beyond its current borders. Guest editors Deborah Estrin, Ramesh Govindan, and John Heidemann, working with Senior Editor Andy Rosenbloom, invited many of the leading experts in this embedded quest to provide the latest news and greatest technologies to soon be invisibly woven into our daily lives. You will learn of new appliances for networking the home, automated patient-monitoring devices, distributed microsensing, wireless network standards, autonomous robots, even smart paint! We hope you find these reports as fascinating as you do informative.


This paper will approach the impact of new technologies in the legal field, especially in Competition Law. More specifically, we will look at Big Data's influence on the Merger Control. Thus, we will examine some characteristics of the new business models in the Digital Age, such as the two-sided markets, network effects and Sharing Economy. In the following, we will observe some views that exploit the changes in the antitrust analyzes currently, taking into account the emergence of increasingly dynamic markets. Finally, to contextualize some changes in the traditional methods of Merger Control we will analyze the decisions of the Federal Trade Comission (FTC) and the European Commission on the Google and DoubleClick Concentration Act, occurred in 2007.


Adenosine is a small ubiquitous molecule known for its role as an energy and genetic code building block. Adenosine also serves as a ligand for Adenosine receptors, members of the G-protein coupled receptor superfamily and is involved in many physiological processes including regulation of sleep and the level of arousal, neuroprotection, regulation of seizure susceptibility, locomotor effects as well as involved in many pathophysiological conditions. Alomone Labs offers antibodies to all Adenosine receptors, providing an essential tool in the understanding of this system in normal and disease states. Although this system is clearly functional in the periphery, this short review mainly focuses on the role of adenosine and its receptors in the brain.


There are three components of error in the ability of land-atmosphere models (e.g., BATS, SiB, etc.) to simulate/predict observed land-surface state variables and output fluxes (e.g. lambdaE, H, Tg, Q, etc.). The first is caused by model structural error associated with simplifications and/or inadequacies in the functional representations of underlying physical processes. The second component is measurement error associated with the input and output data. The third is caused by error in specification of the values of the model parameters. Automatic parameter tuning (model calibration) methods allow minimizing of the parameter error, thereby obtaining an estimate of the remaining error components. This work describes an automatic multi-criteria approach and its use to tune all 27 parameters of the BATS model using data measured in the field. The parameters were adjusted to simultaneously optimize the ability of the model to reproduce observed values of several output fluxes and/or state variables (e.g., latent heat flux, sensible heat flux, ground temperature, etc.). The results indicate that not only does the procedure result in conceptually reasonable and consistent parameter estimates, but the calibrated model is able to provide significant improvement in performance (33% or more reduction in error) over the "un-calibrated" model (i.e., using the BATS default parameter values for the associated region). Substantial improvements of this kind can have important implications for studies that seek to evaluate alternative model structures or to regionalize parameters. To reduce the dimensionality of the optimization problem a multi-criteria extension of the Regionalized Sensitivity Analysis (RSA) has been developed.


To integrate urban and rural education requires us to develop rural school culture,so rural schools must lay emphasis on basic education,stress local cultural identity and strengthen the communication between rural and urban schools.Currently to develop rural school culture there exist such confusions:whether to pursue high admission rates or to live with the unfavorable reality;whether to educate in a comprehensive way or to emphasize only students' intellectual growth;whether to introduce modern urban culture or to carry on the traditional value of rural culture;whether to get away from home and farming or to stay home farming;and whether to develop only general education or to teach vocational skills as well.Rural school culture should adhere to the coordination principle of integrating urban and rural education,and take the following new value orientations:promote basic qualities of rural students and cultivate them to be qualified citizens;develop students' acceptance of and self-confidence in their local rural culture;meet the demands to develop rural culture by varied means;and serve the aim of developing education and culture simultaneously in urban and rural areas.


Entrepreneur Development Institutes have been in Jammu & Kashmir and numerous interventions to encourage entrepreneurship have been initiated in the state. However, not enough progress has been achieved till date. This can be attributed to the lack of understanding of the attitudes and perceptions among the youth towards entrepreneurship. In this study, the author attempted to find out those factors which have an influence on the attitude of youth towards entrepreneurship. The results of the study indicated that youth of Kashmir view self-employment as a viable option but potentially a risky path. It is therefore important to provide knowledge and guidance to them so that they will pursue entrepreneurship as their career path.


Survival benefit (SB) for first liver transplantation (LT) is favorable at Model for End‐Stage Liver Disease (MELD) ≥15. Herein, we identify the MELD threshold for SB from repeat liver transplantation (ReLT) by recipient hepatitis C virus (HCV) status and donor risk index (DRI). We analyzed lab MELD scores in new United Network for Organ Sharing registrants for ReLT from March 2002 to January 2010. Risk of ReLT graft failure ≤1 year versus waitlist mortality was calculated using Cox regression, adjusting for recipient characteristics. Of 3057 ReLT candidates, 54% had HCV and 606 died while listed. There were 1985 ReLT recipients, 52% had HCV and 567 ReLT graft failures by 1 year. Unadjusted waitlist mortality and post‐ReLT graft failure rates were 416 (95% confidence interval [CI] 384–450) and 375 (95% CI 345–407) per 1000 patient‐years, respectively. Waitlist mortality was higher with increasing waitlist MELD (p < 0.001). The MELD for SB from ReLT overall was 21 (21 in non‐HCV and 24 in HCV patients). MELD for SB varied by DRI in HCV patients (MELD 21, 24 and 27 for low, medium and high DRI, respectively) but did not vary for non‐HCV patients. Compared to first LT, ReLT requires a higher MELD threshold to achieve an SB resulting in a narrower therapeutic window to optimize the utility of scarce liver grafts.


Drinking water appears to accelerate weight loss in adults consuming hypocaloric diets when the volume of water is over 1L/d or associated with decreases in urine osmolality. This study explored whether drinking water to dilute urine similarly accelerates weight loss in pre‐adolescents, and if the effect is mediated by cell hydration effects on insulin. Boys and girls (n=25, 9–12y, BMI>;85th%) were randomly instructed to drink enough water to dilute urine or drink water following thirst. All were instructed to avoid other beverages and high glycemic foods. Random saliva insulin, urine osmolality and body weight were assessed weekly for 8 weeks. In completer analyses, participants who ate high glycemic foods at >;50% of meals did not lose significant weight over 8 weeks (−0.4 (0.5)kg). Participants who had high glycemic foods at <25% of meals and urine osmolality <500 mmol/kg over time had significantly lower saliva insulin over time (13(2) vs. 22(3) pmol/L) and greater weight loss (−3.3 (1.2) kg vs. −2.2 (0.9)kg) than participants who also adhered to the study diet but drank to thirst and maintained elevated urine osmolality (887 (27) mmol/kg). Urine osmolality significantly modified the effect of saliva insulin on weight loss. Drinking water to dilute urine may accelerate weight loss for overweight adolescents by limiting insulin levels. Further work is needed to characterize this effect.


Environmental perception researchers frequently use rating scales to measure perceptions of environments. Using data from diverse environmental rating tasks, this study compares the scale values and the intergroup reliability obtained by several different scaling methods. The particular method used to combine ratings influenced neither the scale values nor the reliability of the scale-a simple mean rating produced results almost identical to more complicated scaling methods. We also found that for a wide range of subjective rating tasks, acceptable intergroup reliability can be achieved with small groups. These results may help researchers design more cost effective studies of environmental perception.


The objective of the study was to determine the effect of bamboo leaf on influence rabbit doe milk production and kits mortality during 3 weeks first of age. Thirty six does aged 6-12 months, divided into three blocks, of four treatment diets, were used in our replicity. The diet treatments used bamboo leaf meal: 0% (P0), 2% (P1), 4% (P2), and 6% (P3). The parameters observed were: dry matter intake, doe's milk production, kits mortality, and kit as level: body weight gain. The results showed that supplementation of bamboo leaf meal increased (P < 0,05) dry matter intake whereas doe milk production, kits mortality, body weight gain of kits during 3 weeks experiment were not affected by bamboo leaf meal supplementation


We study the critical behavior of a probabilistic automata network whose local rule consists of two subrules. The first one, applied synchronously, is a probabilistic one-dimensional range-one cellular automaton rule. The second, applied sequentially, exchanges the values of a pair of sites. According to whether the two sites are first-neighbors or not, the exchange is said to be local or nonlocal. The evolution of the system depends upon two parameters, the probability p characterizing the probabilistic cellular automaton, and the degree of mixing m resulting from the exchange process. Depending upon the values of these parameters, the system exhibits a bifurcation similar to a second order phase transition characterized by a nonnegative order parameter, whose role is played by the stationary density of occupied sites. When m is very large, the correlations created by the application of the probabilistic cellular automaton rule are destroyed, and, as expected, the behavior of the system is then correctly predicted by a mean-field-type approximation. According to whether the exchange of the site values is local or nonlocal, the critical behavior is qualitatively different as m varies.


A new case of integrability by quadratures of the general Riccati equation is discussed. Some possibilities of its use in molecular physics are demonstrated by the example of vibrational-translational or rotational-translational relaxation of a small amount of diatomic molecules in a structureless gas.


The social, biological and historical context of non-accidental children's injuries is discussed. Clinical features of physical, emotional, sexual and artefactual abusive injuries are presented. The importance of considering natural, disease and accidental causes is stressed.


Abstract A study has been made of mill-annealed and cold-worked duplex Dalmine D22 and D25 stainless steels (75 and 140 ksi) and of cold-worked superaustenitic Dalmine D28-32 steel (110 ksi). The materials have been tested under conditions typical of oil and natural gas wells operating in a severe environment. The effect of environment variables (T, pCO2, pH2S, NaCl concentration, and pH) and cold-working on corrosion properties, particularly sulfide stress corrosion cracking (SSCC), has been investigated. Engineering diagrams have been produced for qualification and selection of the most suitable material for use in a given environment. For duplex steels, the corrosion mechanisms in relation to environmental variables, applied stress, and microstructure have been examined from the microstructural aspect.


The Hippo pathway is evolutionarily conserved and known to regulate diverse cellular processes, including cell survival, proliferation, differentiation, migration, and organ size. The key regulator of Hippo pathway is transcriptional enhanced associate domain (TEAD) transcription factors, which directly bind with YAP/TAZ and then drive the multiple signaling by activating target gene expression on nuclear. Loss-of-function mutations in the upstream activators, NF2-LATS1/2-MST1/2, trigger YAP/TAZ nuclear translocation and target gene transcription (Hippo-off state). This YAP/TAZ-TEAD complex is overexpressed and leads to metastatic progression in various cancers including malignant mesothelioma, NSCLC, ovarian cancer or cholangiocarcinoma. A recent development in targeting the Hippo pathway has been focused on the discovery of a central lipophilic pocket in TEAD amenable to the small-molecule binding site of autopalmitoylation. Within this lipophilic palmitate pocket, post-translational S-palmitoylation of TEAD at a conserved catalytic cysteine (Cys) residue (e.g., C380) leads to TEAD stabilization and is believed to be critical for maintaining appropriate protein folding to enable the formation of the transcriptionally active YAP/TAZ -TEAD complex. Therefore, targeting the palmitate pocket with allosteric small molecules inhibitor disrupt the formation of the YAP/TAZ-TEAD complex and modulate YAP/TAZ-TEAD driven gene transcription. We have identified a series of novel, potent small-molecule inhibitors of the YAP/TAZ-TEAD transcriptional complex. It showed under 20 nM of potency in the inhibition of TEAD luciferase reporter assay in MCF7-TEAD-luc cells. These TEAD inhibitors inhibited YAP/TAZ-TEAD protein-protein interaction in H226 cells harboring neurofibromin 2 (NF2) alteration. In addition, our lead compounds exhibited dose-dependent growth inhibitory effects in Hippo pathway-altered cancer cell lines and reduced the YAP/TAZ-TEAD target gene expression, CTGF, and CYR61 in H226 cells. Our lead compounds, singled out and optimized based on in vitro functional assay, displayed favorable pharmacokinetic and safety profiles. Furthermore, orally administered lead compound effectively suppressed tumor growth within tolerable doses in xenograft mice with tumors harboring NF2 alteration as a major upstream molecule of the Hippo pathway. In summary, we pointed our novel YAP/TAZ-TEAD inhibitors that showed excellent efficacy in Hippo-altered mutant cancer in vitro and in vivo xenograft models. These data best support a therapeutic option for the treatment of cancers with amplified or overexpressed YAP, TAZ, or TEAD genes. Further preclinical studies will be performed and reported soon after the establishment of a preclinical candidate.
 Citation Format: Jisook Kim, Seung Hyun Jung, Seon Yeong Han, Jihee Yoon, Minjeong Kim, Jooyun Byun, Heesun Moon, Eunyoung Lee, Yu-Yon Kim, Hyunjin Park, So-Ye Jeon, Young Gil Ahn, Young Hoon Kim, Kwee Hyun Suh. Antitumor activity of novel and potent YAP/TAZ-TEAD inhibitorstargeting the Hippo pathway in solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1614.


Adrian Flint is currently Lecturer in Development Politics at the School of Sociology, Politics and International Studies/University of Bristol. His main research interests lie within the field of NorthSouth relations and include issues such as global trade, poverty alleviation, sustainable development, HIV/AIDS and European Union development policy. His most recent monograph, HIV/AIDS in SubSaharan Africa: Politics, Aid and Globalization, was published by Palgrave Macmillan in 2011. He can be contacted at firstname.lastname@example.com


To evaluate the effect of imatinib mesylate (STI571, Gleevec) on primitive/committed malignant progenitor cells in chronic myelogenous leukemia (CML) and to further elucidate the mechanisms involved in CML relapse, bone marrow-derived, malignant, BCR/ABL + Flk1 + CD31CD34 − cells with hemangioblastic characteristics from CML patients were labeled with carboxy-fluorescein diacetate succinimidyl diester dye to enable high-resolution tracking of cell division. Then they were cultured in Methocult GF+ media with or without STI571. After culture, the cells were separated by fluorescence-activated cell sorting into populations of viable quiescent versus cycling cells. Then the mechanisms involved in CML stem cells that became resistant to STI571 were studied. We found that in the most sensitive cases, STI571 killed almost all dividing cells; however, a significant population of viable BCR/ABL-positive cells were recovered in the undivided peak and confirmed to be the leukemic stem cells. STI571 also appeared to exhibit antiproliferative activity on the quiescent population. We further demonstrate that apoptosis was restricted to dividing cells, whereas nonproliferating BCR/ABL + Flk1 + CD31CD34 − cells were resistant to apoptosis induced by imatinib, Ara-C, VP-16, ceramide, or arsenic, either alone or in combination. These studies suggested that CML primitive stem cells remain viable in the presence of STI571 and that inhibition of BCR/ABL tyrosine kinase by STI571 restores normal hematopoiesis by removing the proliferative advantage of CML committed progenitors but that elimination of all CML progenitors may not occur. So despite dramatic short-term responses in vivo, such in vitro insensitive to STI571, might translate into disease relapse after prolonged therapy.


We consider the stochastic nonlinear Schrodinger equations on a half-line under Dirichlet brown-noise boundary conditions. We establish the global existence and uniqueness of solutions to the initial-boundary value problem with values in H1. We are also interested in the regularity behavior of solutions near the origin, where the boundary data are highly irregular.


Abstract An automatic flow-through dosing apparatus was used to determine the effect on Tilapia aurea of acute and chronic exposure to un-ionized ammonia. For fish not exposed to ammonia prior to acute testing, the 48-hour median lethal concentration (LC50) was 2.40 mg/liter un-ionized ammonia. After fish were exposed to sublethal concentrations of un-ionized ammonia (0.43–0.53 mg/liter) for 35 days, concentrations as high as 3.4 mg/liter caused no mortalities within 48 hours. Histopathological changes occurred in the gills of fish given both nonlethal and acute doses of ammonia. Capillary congestion, hemorrhaging, and telangiectasis were common symptoms of gill abnormalities.


This volume is the first work published on the Theodore L. Glasgow Memorial Publication Fund, an anonymous gift to Yale University in memory of Sub-Lieutenant Theodore L. Glasgow of the British Royal Naval Air Service, who was killed in action on the Ypres front. Mr. Laski has already won for himself a preeminent place among students of political theory. His study of de Maistre, his essay on "The Problem of Sovereignty," and his various review articles are all marked by a singular depth of penetration into the realities of political phenomena, by an ability for unerring criticism of the weaknesses and limitations of accepted doctrines, and by an unusual degree of constructive originality and suggestiveness. The volume under review develops in somewhat broader fashion the thesis of the earlier work on "The Problem of Sovereignty." The first chapter deals with the general problem of the authority of the modern state. The state is viewed as only one of the innumerable group-units possessing corporate personality. Its raison d'etre lies in its ability to contribute to the needs of the individuals who compose it. It is essentially a public service corporation. It possesses no sacrosanct character; it is not an end in itself. The juristic doctrine which clothes it with sovereignty is a fiction. In last analysis, the action and the power of the state are identical with the action and power of the persons, assemblies, or classes within it who actually rule. Obedience to the state rests, like obedience to the mandates of any other corporate group, ultimately upon the response of the individual conscience. In case of conflict between the claims of the state and those of other corporate, bodies, even though its demands be fortified by the sanction of popular majorities,


Microsatellites or simple sequence repeats (SSR) can be used for genomic mapping, population studies and DNA fingerprinting. We have identified and characterized SSR containing sites in the filamentous ascomycete Magnaporthe grisea, the causal agent of rice blast disease, by constructing and screening an enriched library and by searching public databases. Both methods proved useful in uncovering microsatellites. A total of 40 SSRs (25 from the database screen and 15 from the enriched library) were screened for product length polymorphism on six Magnaporthe grisea isolates including GUY 11 and 2539, the parents of a cross from which a genetic map of the fungus has been developed. The number of alleles at each site ranged from one to six when assayed on 3% agarose gels. Inheritance and linkage was determined for twenty polymorphic sites in 60 F1 progeny from the above cross. Analysis of allele segregation showed that all the markers segregated in the expected 1:1 ratio. Map positions were determined for all 20 with at least one marker mapping to each of the seven known chromosomes. The SSR markers were stable and easy to assay. A preliminary population study using the developed SSR markers on isolates from Thailand proved to be useful in helping to group and classify these individuals. (Resume d'auteur)


One of the triumphs of the 1989 revolutions was the revival of the concept of civil society. In this research we propose to trace the origins of this concept in the dissident phenomenon that appeared in the 70's in the Communist Bloc. The center point of our analysis is the political and historical context of Czechoslovakia. The dissident phenomenon will be interpreted from the perspective of Vaclav Havel political thought, one of the Czechoslovak dissidents. For Havel, dissidence is an alternative to the political context, particularly, what the author calls, post-totalitarianism. One of the main practical results of the dissident phenomenon is the constitution of parallel structures to that of the State. The discourse of this independent society is antipolitical, not as a negation of the politics, but as a rethinking of politics from an ethical base. For Havel, post-totalitarianism, in its communist image corrupted human life through politics, imposing a system of falsehood and an ideologized life, thus negating the possibility of finding an authentic life, within the truth. Therefore, the first step that is made in the direction of the life within the truth will lead inevitably to a confrontation of the individual with the political system and automatically the system will classify him as an opponent, and the individual will risk his own liberty, and in the more extreme cases, his own life. This change in the perspective of the people is done through an assumption of one's responsibility towards one's identity – corrupted by the regime – and towards the world. The parallel polis formed by dissidents is thus a structure whose purpose is to push the State out of the individuals' private life and to provide an alternative public sphere. For that reason, the parallel polis is the precursor of the civil society, but this is a civil society that, contrarily to the occidental perspective, does not require the presence of the State. The parallel polis, as the name indicates, does not interact with the State, and represents a sphere that connects the individual to his community and not to the State.


This paper will present and discuss the use of finite element technique for simulation test of functionality of automotive allow wheel nature during operation. A specific design wheel is used. The load for stress distribution and displacement data subjected to loading on alloy wheel is viable trough the finite element model. The result and how wheel performed is discussed.


This article has been adapted from the paper that won the IADC Young Author 2016 Award and it was published in the proceedings of IX PIANC-COPEDEC conference in October 2016. It is reprinted here with permission. An integrated analytical method was developed and applied to identify the optimal channel layout and dredging depth that allowed for safe navigation; enabled the operation of the required amount of ships per year; and at the same time reduced dredging costs. This method developed by CB&I included an integrated approach combining channel design, hydrodynamic and sedimentation modelling, ship manoeuvring simulations and static and dynamic port operation simulations. The results allowed reducing channel dredging depths up to 3m, causing decreases of capital dredging volumes of about 10 million m3. Based on the outcomes of the dynamic simulation tool, it can be concluded that the proposed integrated approach for channel design provides relevant information for the definition of the business model of the port. This is because it provides easy access to the impacts of changing vessel class or draft in both the cargo trade capacity and CAPEX/ OPEX. This in turn helps to identify the optimal configuration for commercial interests and internal rate of return (IRR) of the terminal.


Taking into consideration high losses and long period required for carp breeding up to market size and weight, the research focused on assessment of possibilities of breeding carp larvae and fingerlings in the recirculating system. Three-day larvae of the average individual weight of 1.3 mg•ind-1 were settled in three 150-liter tanks. Each thank contained 30 000 larvae. Water temperature, as an important factor for growing larvae and fingerlings, varied between 23-24oC throughout the breeding period, and concentration of dissolved oxygen varied from 4.7 to 8 mg•L-1. Feeding of larvae started immediately after settling in with the nauplius larvae Artemia salina, which were decapsulated and prepared for feeding 1 day earlier. Afterwards, live feed was replaced with forage mixture. The daily amount of extra feed was given at 2-hour intervals. After the 31st farming day, the mass of fingerlings bred in the recirculating system depended on feed type and varied from 855.3 to 1123 mg•ind-1.


"Because people rely on the use of their voices all the time, it becomes a comfortable practice," said Nitesh Saxena, Ph.D., the director of the Security and Privacy In Emerging computing and networking Systems (SPIES) lab and associate professor of computer and information sciences at UAB. "What they may not realize is that level of comfort lends itself to making the voice a vulnerable commodity. People often leave traces of their voices in many different scenarios. They may talk out loud while socializing in restaurants, giving public presentations or making phone calls, or leave voice samples online."


A longitudinal broadband damper system to control coupled bunch instabilities has recently been constructed and installed in the 920 GeV proton accelereator HERA-p at the Deutsches Elektronen-Synchrotron DESY. This represents one of the attempts to increase the specific luminosity at HERA by reducing the bunch length. Without additional damping the bunch length is about 1.5 ns (FWHM) at the beginning of a typical luminosity run. The bunch length is defined by the initial emittance after injection and by the acceleration process where multiply occuring coupled bunch instabilities provoke bunch length blow up at discrete energies during the ramp. The feedback system measures the phases of all bunches and calculates corrections in real time (bunch spacing: 96 ns) which are then applied to the beam via a longitudinal feedback kicker. The controller has to be able to deal with a slowly changing synchrotron frequency (20‐80 Hz). Transverse and longitudinal emittances of a proton beam are very sensitive to any (noise-) exitation because of the missing synchrotron radiation damping. Therefore the feedback system for a hadron beam accelerator is much more challenging than that for electron accelerators where longitudinal coupled bunch feedback systems are widely used.


BaTi1-xZrxO3 (x=0–0.1) thick films were prepared by a screen-printing method on Pt bottom electrodes using ceramic substrates in the firing temperature range from 1250°C to 1450°C. The dielectric, ferroelectric and electric-field-induced strain properties of the thick films were examined in comparison with those of bulk ceramics. The optimum firing temperature to obtain maximum remanent polarization was 1400°C for the thick films. The phase transition temperatures were controlled by varying composition x for the thick films as well as the bulk ceramics. The maximum remanent polarization of 14.4 µC/cm2 for the thick film was obtained at x=0.025 in the orthorhombic phase.


Objective To explore the change trends of epidemiological and clinical feature,risk factors,outcome of nosocomial infection of very low birth weight infant(VLBWI) in neonatal intensive care unit (NICU).Methods The VLBWI whose birth weight were less than 1 500 g and whose length of stay were more than 48 hours were selected in this study in NICU of Peking University Third Hospital within 11 years(from Jan.1,1998 to Dec.31,2008).The related clinical informations of VLBWI were recorded and analyzed in detail.Eleven years were divided into 2 phase,the first phase was from Jan.1,1998 to Dec.31,2003 and the second phase was from Jan.1,2004 to Dec.31,2008.In each phase,the infants were divided into 2 groups according to nosocomial infection as infection group and non-infection group.The data from 2 phases and 2 groups were analyzed by SPSS 12.0 software.Results There were 31 cases and 127 cases of VLBWI in 2 phases,respectively.There were 10 cases and 46 cases who had nosocomial infection in 2 phases,respectively.There were no significant difference in the incidence percentage for nosocomial infection between 2 phases (32.3% vs 36.2%,P=0.679).There were significant difference in the constituent ratio of septicemia between 2 phases (P0.05).In the first phase,the isolated bacteria were all gram-negative bacillus,and in the second phase gram-negative bacillus accouted for 52.6% and gram-positive cocci accouted for 50.0%.In the first phase,the factors correlated with nosocomial infection were not achieved.In the second phase,the factors correlated with nosocomial infection in VLBWI were gestational age,birth weight,mechanical ventilation,ventilatory support with trachea cannula,parenteral nutrition,central vein cannula,congenital heart disease,respiratory distress syndrome and the duration of parenteral nutrition,central vein cannula,mechanical ventilation and trachea cannula.The central vein cannula was significantly correlated with septicemia in the second phase(P0.05).The Logistic regression analysis showed that mechanical ventilation and parenteral nutrition were the most significant risk factors in the second phase.Conclusions The incidence percentage for nosocomial infection dose not increase but presents an ascending trend with the increase of survival rate of VLBWI.The change of characteristics of the factors and epidemiological features correlated with nosocomial infection are found,so as to prevent and treat nosocomial infection of VLBWI with the definite direction.


EDITOR—The NHS Executive has recently established a process for identifying "beacons of excellence" within the NHS.1 As members of the regional panel assessing the applications for beacons in primary care in the South West, we were struck by the number of applications from practices that were either actively involved in research and development or contained one or more partners with fellowship by assessment. We therefore analysed the applications, looking at these two indicators.

Of the applications for beacon status, two had research and development funding only, …


Energy-localized C/I.j DO;2 molecular orbitals, atomic charges, valencies and bond indices of the sulphidoborons, XBS (X = H, F. Cl, OH. NH 2) and XSB (X = F. Cl) have been calculated in an attempt to elucidate their electronic structures. For HOBS and H, NBS the sp-basis set and for the rest both sp- and spd-basis sets have been employed. The localized molecular orbitals (LMO) are obtained in general with a very high degree of localization. In XBS molecules, the boron atom is fractionally bonded (HBS isan exception), the BSbond indices vary from 2.2 to 2.6 suggesting that they are polar triple bonds, the HB bond is a covalent single bond and other XB bonds are considerably ionic and possess some double bond character. There is also a lone pair orbital each on F, Cl, 0 and S atoms. The highly ionic nature of the FB, ClB, OB and NB It-bonds, however. suggests that three lone pair orbitals should be assigned to F and Cl each, two to 0 and one to the N atom. The localized structures ofXSB molecules contain a single bond (XS),a highly polar double bond (SB),three lone pair orbitals on X and one each on Sand B atoms. Inclusion of 3d-orbitals for second-row atoms in the basis set does not have any noticeable effect on the bonding in XBS molecules, but increases to a considerable extent the degree of delocalization of the BSIt-bond in elBS and the It-type lone pair orbitals on the halogen atoms in the isomeric species, XSB. This enhanced delocalization increases the bond index of the XS bonds to a value appropriate for a polar double bond and decreases the double bond character of the SBbond. On the basis of the LMO structures ofXBS and XSB molecules some remarks have been made


We describe an aperture synthesis radio tele- scope optimized for studies of the Galactic interstellar medium (ISM), providing the ability to image extended structures with high angular resolution over wide elds. The telescope produces images of atomic hydrogen emis- sion using the 21-cm H i spectral line, and, simultaneously, continuum emission in two bands centred at 1420 MHz and 408 MHz, including linearly polarized emission at 1420 MHz, with synthesized beams of 1 0 and 3:4 0 at the respective frequencies. A full synthesis can achieve a con- tinuum sensitivity (rms) of 0.28 mJy/beam at 1420 MHz and 3.8 mJy/beam at 408 MHz, and the 256-channel H i spectrometer has an rms sensitivity of 3.5B 0:5 sin K per channel, for total spectrometer bandwidth B MHz and declination . The tuning range of the telescope permits studies of Galactic and nearby extragalactic objects. The array uses 9 m antennas, which provide very wide elds of view of 3.1 and 9.6 (at the 10% level), at the two frequencies, and also allow data to be gathered on short baselines, yielding extremely good sensitivity to extended structure. Single-antenna data are also routinely incorpo- rated into images to ensure complete coverage of emission on all angular scales down to the resolution limit. In this paper we describe the telescope and its receiver and corre- lator systems in detail, together with calibration and ob- serving strategies that make this instrument an ecient survey machine.


Calcific aortic valve disease (CAVD) is a chronic disorder typified by ectopic mineralization and fibrosis of the aortic valve (AV), which may progress to the stage of aortic stenosis (AS). Studies performed in the last decade have underlined that lipids and inflammation are important mediators of AV calcification and fibrosis. Intricate interactions between genes and the environment are believed to contribute to the development of CAVD. In this regard, Mendelian randomization studies have underscored that lipoprotein(a) [Lp(a)] and LDL were probably causally related to CAVD and AS. Among risk factors, age, type 2 diabetes, and hypertension have also been associated with CAVD. Obesity has been, so far, equivocally associated with CAVD. Small-scale and underpowered studies have provided conflicting results about the association between obesity and CAVD. Body mass index (BMI), a measure of total adiposity, has been shown to be either inversely or positively associated with the prevalence of CAVD. Hence, the association between obesity and CAVD has remained unsettled, until Larsson et al. in this issue of the journal provided convincing evidence that obesity is associated with an increased risk of AS. In the Cohort of Swedish Men and the Swedish Mammography Cohort including 71 817 subjects with a mean followup of 15.3 years, 1297 individuals developed AS. Larsson and colleagues found after comprehensive adjustment for covariates that overweight (BMI 25.0–29.9 kg/m) and obesity (BMI >_30 kg/m) increased the risk of AS by 1.2and 1.8-fold, respectively. In addition, overweight [hazard ratio (HR) 1.6] and obesity (HR 2.0) were also independently related to a hard endpoint such as surgical cases of AS requiring an aortic valve replacement (AVR). Though the study by Larsson et al. relied on the International Classification of Diseases codes to identify AS cases, the large number of incident cases and the strong association between overweight–obesity and surgically confirmed cases of AS provides compelling evidence that excessive adiposity is independently related to CAVD.


The effects of current and sound and light signals on the properties and thickness,in particular,of micro-arc oxidation coatings were analyzed.The micro-arc breakdown at different coating-forming voltages was discussed with respect to experiment and calculation,and the correlation between the coating thickness and coating-forming voltage was analyzed.It was found that micro-arc breakdown showed different features under different coating-formation voltage range.Moreover,the coating thickness was highly dependent on the coating-formation voltage.


The risk of an epidemic developing results from the pathogen, its host, the environment, human intervention through the cropping system, and their interactions. Disease is conventionally represented by a tetrahedron, each extremity of which is occupied by one of these factors. However, few parasite management systems are based on all these elements at the same time. For instance, cropping system is rarely taken into account. Yet, it will be shown that all the components of the tetrahedron need to be taken into account for optimum parasite management and durable control, especially the cropping system. Indeed, with knowledge of the physical, technical and biological attributes of a plantation, it is possible to assess the extent of the epidemic risk to which it is exposed, and deduce control recommendations which are both in relation to that risk and adapted to the cropping system. Some considerations on coffee rust, American leaf spot of coffee, coffee berry disease, tracheomycosis and crespera are given. (Resume d'auteur)


-The rise of digital journalism, the amount of news and the continuous number of people accessing these contents, often generates that third parties, through web platforms and social networks, have the opportunity to persuade readers with content that alters their opinion or behaviour on a topic, so it is necessary to classify news using Natural Language Processing (NLP) techniques. This work seeks to experiment with pre-trained Transformer models using transfer learning and fine tuning to obtain a model capable of determining whether a news item is satire, opinion or information. To do so, we use a labelled dataset of news in English presented for the SemEval 2023 campaign, translating it into Spanish to experiment also in this language. We use pre-trained Transformer models for text classification tasks in the mentioned languages, thus, we compare several models and their predictions using evaluation metrics. The results give indications of the goodness of the models considering the subjective type of news, in the case of satire and opinion, and objective for information, thus contributing to future research related to text classification, specifically news categorisation.


This article grasped butterfly resources and distribution in Jiamusi district,also introduced investigation knowledge of butterfly resources through researching butterfly resources several years.This article put forward the means and measures of development and utility of butterfly resources,expected people to develop and utilize the butterfly resources.


An assembly sequence planning approach of space assembled antennas is presented in this paper, based on simulated annealing algorithm. Firstly, the geometrical model of the shortest assembly path of `space station - arms - manipulator' system is constructed with the consideration of inherent radius. Then, the optimization model of assembly sequence planning is established, and the optimization objective, design variables and constraints are discussed, separately. Based on the analysis of the characteristics of the antenna sequence planning problem, simulated annealing algorithm is adopted to solve this optimization problem. Simulation results verify the effectiveness of the proposed method.


A new control model for the study of biomechanical simulation of human movement was investigated using rowing as an example. The objectives were to explore biological and mechanical alternatives to optimal control methods. The simulation methods included simple control mechanisms based on proportional and derivative (PD) control, consideration of a simple neural model, introduction of an inverse dynamics system for feedback, and computational adjustment of control parameters by using an evaluative criterion and optimization method. By using simulation, appropriate rowing motions were synthesized. The generated rowing motion was periodic, continuous, and adaptable so that the pattern was stable against the mechanical force and independent of the initial condition. We believe that the simulation model is not only practical as a computational research tool from a biomechanical-engineering viewpoint but also significant from the point of view of fundamental biological theories of movement.


The annual growth in the consumption of isoprene rubbers dictates manufacturers to searching for the new methods of its production. An intermediate product in the production of isoprene rubbers is the synthesis of a monomer - isoprene. The main industrial methods for its production in Russia are synthesis processes from isobutylene and formaldehyde and two-stage dehydrogenation of isopentane. The article analyzes and selects an effective catalyst for the stage of isoamyl alcohol dehydration in the synthesis of isoprene from isopentane.


The aim of the research is to determine how many companies in the Czech Republic which have been permitted to reorganize submitted a proposal to allow the reorganization before bankruptcy decision and also how many companies have been permitted to reorganize simultaneously with the bankruptcy decision. The particular goal was also to determine how many companies that have been allowed reorganization had approved reorganization plan to begin the recovery business process. Within the application part of this paper authors focus on specific case of reorganization in lottery company Sazka.


In this study, we investigated by running continuous stirred tank reactor the effects of different thermophilic temperatures (55, 60, 65, 70, 75 and 80 o C) for different hydraulic retention times (0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 days, respectively) on the pretreatment of sewage sludge. We found that hydrolysis was mainly determined by temperature instead of hydraulic retention time, i.e. the higher the temperature was, the more dissolved COD produced, while extension of hydraulic retention time did not significantly increase dissolved COD products. Acidogenisis had the highest products when temperature was at 70 o C or 75 o C and for a hydraulic retention time around 2 days, under the conditions of which higher acidogenic activity was maintained and methogenic activity was inhibited. We also determined the minimum guaranteed retention time for each temperature when faecal streptococci were totally inactivated.


We introduce a notion of [Formula: see text]-coordinated module twistor for a [Formula: see text]-coordinated module of a nonlocal vertex algebra. Furthermore, we study twisted tensor products and L-R-twisted tensor products of [Formula: see text]-coordinated modules of nonlocal vertex algebras and we unify these two constructions by [Formula: see text]-coordinated module twistors.


Objective To explore the effects of venlafaxine on chronic unpredictable stress induced expressions of phosphorylated form of the cyclic-AMP response element binding protein(pCREB) and brain-derived neurotrophic factor(BDNF) in the rat hippocampus.Methods Sprague-Dawley rats were exposed to different chronic unpredictable stressors(CUS) for 4 weeks and were treated with venlafaxine(5 and 10 mg/kg,respectively) thereafter.All rats were divided into 8 groups with 10 rats in each group as follows: normal control(NC)、chronic unpredictable stress(MD0)、CUS+saline 14 days(MD1) and CUS+saline 28 days(MD2)、CUS+venlafaxine(5 mg/kg) 14 days(LV1) and CUS+venlafaxine(5 mg/kg) 28 days(LV2)、CUS+venlafaxine(10 mg/kg) 14 days(HV1) and CUS+venlafaxine(10 mg/kg) 28 days(HV2).The expressions of phosphorylated form of the cyclic-AMP response element binding protein(pCREB) and brain-derived neurotrophic factor(BDNF) were assessed using immunohistochemistry and Western blot.Results CUS down-regulated the expressions of pCREB and BDNF in the hippocampus of CUS rats(P0.05).Low dose of venlafaxine(5 mg/kg) treatment increased expressions of these proteins(P0.05),whereas high dose of venlafaxine(10 mg/kg) decreased expression of these proteins,but the differences between high dose treatment rats and the CUS rats were not stastically significant(P0.05).Conclusions Low dose of venlafaxine(5 mg/kg) treatment are probably associated with neuronal plasticity.The present findings suggest that neuronal plasticity-associated proteins such as pCREB and BDNF play an important role in depression.


This article focuses on the Convent of the Incarnation, which pertained to the Order of the Immaculate Conception, and is located in the village of Escalona (Toledo, Spain). This Conceptionist convent, which was called «las Gasquinas», was originally a beguinage instituted in 1510 by Francisca Gasquina. When one of their daughters entered the beguinage, the Dukes of Escalona decided to turn it into a monastery of the Order of the Immaculate Conception, which at that time was flourishing, since they had received their own rule in 1511. The Convent of the Incarnation of Escalona, recently closed, provides a typical example of a religious foundation of the sixteenth century, created by powerful nobles who, in addition to satisfying their spiritual concerns and seeking greater social prestige, wanted to ensure the future of part of their female offspring. This article also showsother common characteristics of cloistered lifeand highlights the vocational crisis of our presenttimes.


This document has been designed primarily to meet the needs identified by industry trainers in the automotive sector for materials, activities and trainer's notes in the area of basic mathematical skills. The particular target group was the non-trades employees in vehicle manufacturing who were undertaking the Vehicle Industry Certificate. However, most of the activities address issues and skills applicable to any modern workplace, and are general enough to be of value to most workers. Much of the material takes a focus on the use of language. Numeracy on the Line is therefore applicable to industry trainers, TAFE teachers, adult literacy and numeracy teachers and ESL teachers in a range of workplace or general educational settings. There are eight sections including work on calculators, decimals, percentages, charts and graphs, and averages.


Client card describing work completed at the Roman Bronze Works Foundry for Mr. Angelo P. Bizzozero, including a job number, brief description, monetary amount, and dates associated with each entry. Piece included: "St. Anthony" (4'4").


Objective: To observe the effect of treatment on advanced large interstine cancer with traditional Chinese medicine Fuzhenghewei liquid medicament.Methods: Fuzhenghewei group treat cancer with Fuzhenghewei liquid medicament,Fuzhenghewei liquid medicament and chemotherapy group treat cancer with Regimen OLF and Fuzhenghewei liquid medicament,Traditional Chinese medicine comparison group treat cancer with the injection of Java Brucea fruit emulsion.After treatment,to observe karnofsky criteria,the median survival time and survival rate.Result: Fuzhenghewei liquid medicament can improve living quality,prolong survival time and enhance survival rate of patient obviously.Conclusion: Fuzhenghewei liquid medicament can improve living quality,prolong the life of advanced large intestine cancer patient.


I would like to begin this essay by thanking Peter Pastor for his careful reading of my article "Heroes, Victims, Role Models: Representing the Child Soldiers of the Warsaw Uprising" which looked at the cultural portrayals of the anti-Nazi revolt and focused, particularly, on contemporary narratives surrounding the underage soldier. By spotting my misreading of the Budapest images, he opened up an important discussion on the afterlife of archival photographs, their (mis)uses, re- and misinterpretations, and crucially, their longevity and continued relevance. I believe it is a timely debate and, as the other essays in this forum show, a debate that is relevant to artists, writers, historians and cultural studies scholars, among others.


finity chromatography purification method combined with a simple kinase assay to search for potential pharmacological inhibitors, and this led to the discovery of roscovitine in Roscoff [4] . This molecule has been used extensively as a pharmacological tool to investigate the cell cycle, synchronize cells, and trigger cell cycle arrest or apoptosis, in order to evaluate its effects on numerous diseases ranging from cancers, viral infections, or neurodegeneration to polycystic kidney disease. While originally roscovitine was believed to exert its effects mainly on proliferating cells, Adriano Rossi and his colleagues (University of Edinburgh) reported that roscovitine also affected neutrophils, key cells in innate immunity deprived of proliferative capacities [5–10] . They discovered that roscovitine could trigger apoptosis of neutrophils, thereby favoring their phagocytosis by macrophages to promote the resolution of inflammation [11] . Notably, this activity was due to the inhibition of CDK7 and CDK9 involved in the regulation of RNA transcription [12] . These observations opened novel perspectives in the field of anti-inflammatory drugs and especially in chronic lung inflammation like that observed in CF patients. CF is indeed a complex genetic disease [13] that involves the mutation of the chloride channel CFTR gene, where the deletion of F508 is the most frequent mutation. Discoveries can take unpredictable paths! In a review presented in the current issue of the Journal of Innate Immunity , Meijer et al. [1] describe the rationale for evaluating roscovitine for the treatment of cystic fibrosis (CF) patients chronically infected with Pseudomonas aeruginosa . Roscovitine is a low-molecular-weight inhibitor of cyclin-dependent kinase (CDK) discovered over 20 years ago during studies on the regulation of cell division using a rather unlikely research subject, starfish oocytes [2] . Marine invertebrate oocytes and eggs have been used for decades to investigate cellular and molecular mechanisms involved in the regulation of the cell division cycle as these cells have a natural break at specific stages in the cell cycle [3] . In parallel to Xenopus oocytes and genetic models such as yeast and Drosophila , they have allowed the identification of the CDK1/cyclin B protein kinase as the major regulator in G2/M cell cycle transition. In fact, this discovery eventually led to the awarding of the Nobel Prize in Physiology or Medicine to Paul Nurse, Tim Hunt, and Leland H. Hartwell in 2001. CDK1/cyclin B is the archetype of CDKs that were found not only to be major players in all steps of the cell cycle but also to display other functions including a role in the central nervous system (CDK5/p25). Given that active CDK1/cyclin B is present in huge quantities in starfish M-phase oocytes, the group of Laurent Meijer at the CNRS (France) developed an afPublished online: April 26, 2016 Journal of Innate Immunity


1 The work was supported by the Federal Target Program "Research and Scientific-Pedagogical Personnel of Innovative Russia for 2009–2013 years", Project No. P651 dated 10.08.2009. Abstract – Results of experimental investigations by electron microscopy, X-ray diffractometry and X-ray spectral microanalysis of the structuralphase state and the element composition of the clad samples in the initial state and treated by hightemperature pulsed plasma flows (HTPPF), depending on the technique of cladding, the composition of a cladding alloy and the regimes of pulsed plasma treatment, have been presented. A method is proposed and a principal possibility is shown of the formation of nanostructured surface layers of metal articles by their preliminary cladding with the use of rapidly quenched nickel-based brazing alloys and subsequent action by gas HTPPF. Under this treatment, a possibility is shown of the formation of nanocrystalline ordered structure with typical cross sizes of the cells changing from 50 to 150 nm.


Thermally induced threshold wavelength shifts of 50 nm have been observed in short cavity length diode lasers fabricated from thin quantum well AlGaAs. Analysis suggests that the high‐energy radiation is generated by transitions between the n=2 level in the conduction band and the n=2 heavy hole level in the valence band. The threshold characteristic temperature (T0) of the laser material is found to be a strong function of cavity length.


G illes Deleuze's essay ''Coldness and Cruelty'' was revised for inclusion in a 1967 work devoted to Leopold von Sacher-Masoch and featuring Sacher-Masoch's Venus in Furs. It was translated into English under the title Masochism and, needless to say, in this context the rubric of masochism overshadows that of sadism. What I hope to draw attention to here is the curious fact that, in a work that must necessarily speak to the question of masochism, Deleuze brings a particular, and particularly acute, attention to outlining the structure of sadism. Of course it might be argued that such an attention is critical to the understanding of masochism, and to some extent this is the case; but if the two forms do not rely on each other for their definition, why is it that Deleuze keeps returning to the question of sadism in his exposition of masochism? It will be claimed that the structure of sadism, above and beyond that of masochism, is in strong resonance with a series of terms that traverse, in subterranean fashion, Deleuze's work from the late 1960s. It is such a tracing that this essay seeks to develop, with the claim that the structures of sadism, the world without others, the third synthesis of time, and the death instinct all mirror each other and reveal not only an extreme formalism but an extreme state of stasis and non-becoming at the heart of Deleuze's early work. I have argued previously that Deleuze has a somewhat fraught relation to the question of movement. Although he, and he and Félix Guattari, are always careful to argue that there need not be actual physical movement for flights or becomings or nomad thought to take place, there is nonetheless a privilege accorded to becoming and the implicit movement it entails, so that a certain dialectic of movement and stasis tends to result, with movement being the favored term. This might be mapped onto Deleuze's privileging of the time of Aion in The Logic of Sense, which is that of the past–future conjunction that he opposes to Chronos, the time of the present. In his discussion of the event, we see an implicit premium placed on the movement of becoming:


This paper addresses a new approach, the optimal path estimation method (OPEM), to implement the time optimal bang-bang control. OPEM is based on feedback information obtained by estimating the distance from the present state to the switching surface along the optimal trajectory. A fuzzy algorithm is used for the implementation of the control logic. The advantages of the proposed method are illustrated by numerical simulations of a multimachine infinite-bus power system.


Quantifying entanglement of multiple subsystems is a challenging open problem in interacting quantum systems. Here, we focus on two subsystems of length $\ell$ separated by a distance $r=\alpha\ell$ and quantify their entanglement negativity (${\cal E}$) and mutual information (${\cal I}$) in critical random Ising chains. Both the disorder averaged ${\cal E}$ and ${\cal I}$ are found to be scale-invariant and universal, i.e. independent of the form of disorder. We find a constant ${\cal E}(\alpha)$ and ${\cal I}(\alpha)$ over any distances, using the asymptotically exact strong disorder renormalization group method. Our results are qualitatively different from both those in the clean Ising model and random spin chains of a singlet ground state, like the spin-$\frac{1}{2}$ random Heisenberg chain and the random XX chain. While for random singlet states ${\cal I}(\alpha)/{\cal E}(\alpha)=2$, in the random Ising chain this universal ratio is strongly $\alpha$-dependent. This deviation between systems contrasts with the behavior of the entanglement entropy of a single subsystem, for which the various random critical chains and clean models give the same qualitative behavior. Therefore, studying multipartite entanglement provides additional universal information in random quantum systems, beyond what we can learn from a single subsystem.


Interest in lumbar disc arthroplasty as an alternative to fusion surgery continues to grow. The goal of disc arthroplasty is to replace the diseased disc while preserving and/or restoring motion at the operated spinal level. Different paradigms exist in the design of total disc arthroplasty devices. The purpose of this study was to compare the in vitro biomechanics of a more constrained ball-and-socket design (Prodisc-L, Synthes Spine and Maverick, Medtronic) and a less constrained mobile-bearing design (Charite, DePuy). The biomechanical performances of the disc prostheses were compared to the fused and harvested spine conditions.Copyright © 2009 by ASME


The objective of this study was to analyze the fluid flow of molten steel in a continuous casting tundish using numerical simulations for better inclusion floatation and its separation. The tundish geometry was designed using Autodesk FUSION 360 and the analysis were performed on ANSYS FLUENT. The investigations were done on steady-state as well as transient conditions. To scale back vortexing and turbulence within the tundish, turbo stoppers and flow modulators, e.g. dam and weirs were placed for an optimized and efficient flow inside the tundish and its behavior on the spacious flow structure was explored. The strategic placements of the flow modifiers produced higher turbulence in the recess region of the tundish resulting in better turbulent flow withinside the inlet region of the tundish. Thereby a more homogeneous fluid flow is formed with better conditions for particle separation. Analysing the flow behavior we have determined the inclusion floatation using particle tracking method form dense discrete phase modelling along with multiphase eulerian-lagragian model. Reduction in dead volumes was achieved in the spatial flow due to better intermixing which further reduced the metal loss and increased the yield of the tundish using the fluid flow analysis. Analyzing eddy formations in the spatial geometry of the tundish structure made it easy to evenly distributes the flow-induced shear. This determined the lesser turbulence on the free surface of the steel flow resulting in less reduction of the liquid steel surface.


In the last twenty-five years a great deal of industry has been devoted to the question of the influences on and meaning of the Constantinopolitan Creed. Much of this question has to do with what we are to make of the pneumatology of Basil the Great. In chapter xviii of the Preface of Volume 3 of the great Maunst edition of St. Basil Maran lists much of the ancient evidence that illustrates the enigmatic character of Basil's writing. Gregory of Nazianzus both in his letters and above all in his funeral oration' felt called to defend his friend against the charge of minimalism which was levelled against him in the 370s. More recently Basil has had his accusers and defenders on precisely the same charge. So, for example, Dom Jean Gribomont O.S.B.2 and others see the disinclination of Basil to apply either 'God' or 'consubstantial'. to the Holy Spirit as evidence of Basil's defective belief in this matter. Fr. B. Pruche, however, in his recent re-edition of the De Spiritu Sancto insists that this omission on Basil's part is not to be understood as a denial of the deity of the third p e r ~ o n . ~ He points to two factors that must be taken seriously: (3 Basil's 'economy', (which even the more outspoken Athanasius praised so highly) meant that for the sake of peace he was prepared not to insist on verbal forms when such insistence would rupture the fragile peace of the church; (ii) Though he does not call the Spirit 'God' expressis verbis, the substance of the doctrine is present in his writings.


Montucaris distincta gen. nov. sp. nov., a new genus and species of hirsutiid, is described from the bathyal floor of the northern South Atlantic, off Brazil. It is easily distinguished from other members of the family by the reduced, one-segmented exopods of pereopods 5 and 6 and the array of stout triangular spines present on the anterior margin of the basis and proximal endopodal segments of the third pereopod. This discovery is notable as it includes the first record of males in the family, demonstrating that hirsutiids are gonochoristic. Developmental stages including mancas, preparatory females and juvenile males were recovered, in addition to numerous brooding females and two morphs of adult males. We infer that the new genus has a life cycle involving non-feeding terminal males with regressed mouthparts. These males display a bizarre cephalic configuration, with a clearly defined transverse dorsal suture on the dorsal cephalothoracic shield just behind the articulation of mandibles, a feature present also in syncarida and in some Thermosbaenacea and that we interpret as secondary. The peracaridan affinities of the Hirsutiidae are firmly established here after settling definitively the oostegitic nature of the setose plates present on the posteromedial margin of the pereopodal coxae of brooding females. The separate ordinal rank for hirsutiids – as the Bochusacea – with respect to the Mictacea, within which they had been previously classified, is favoured here. In addition, we highlight similarities between hirustiids and tanaidaceans that warrant further investigation. © 2006 The Linnean Society of London, Zoological Journal of the Linnean Society, 2006, 148, 169–208.


Wegener's granulomatosis (WG) is a complex multisystem disease that can be associated with morbidity and mortality. The diagnosis of WG in those whose ophthalmic manifestations are the first signs or without systemic diseases is often delayed by ophthalmologists. With the development of laboratory technology and new treatments, the diagnostic and therapeutic level has been dramatically increased. The combination of medicine and ophthalmological approach with prompt therapeutic intervention is recommended.


The article is best seen as a follow-up article in a series of articles about this topic that have previously appeared in The Bible Translator (1992) and in NOT (1997). The article explores the meaning of YHWH in various contexts, and what the implications of this analysis are for Bible translators. It concludes that there are only two legitimate options for representing YHWH, and it provides translators with a clear set of criteria that will help the translator to determine which one of these two representations should be used.


ABSTRACTThe fluctuating velocity field of a planar impinging gas jet is studied using particle image velocimetry, while anti-symmetrically forcing the jet column at the nozzle exit using planar synthetic jets. The jet exit velocity is set to  = 11 m/s providing a jet Reynolds number of , and the impingement distance is held constant at eight times the nozzle width W. Under forcing conditions near unstable frequencies, both the stream-wise and cross-stream fluctuating velocity fields of the jet have very different characteristics than that of the unforced jet. The fluctuating velocity fields reported here were also found to have qualitatively similar features to that of a high-speed self-excited impinging jet. For the highly periodic flow conditions tested, a triple decomposition, and a low order reconstruction of the fluctuating velocity field using proper orthogonal decomposition is employed. These methods allow for the extraction of the coherent velocity and turbulence fields from the forced planar impi...


Background: The obesity epidemic has led to an increase in type 2 diabetes as well as the precursor condition "prediabetes." Prediabetes is defined as blood glucose or hemoglobin A1c levels higher than normal, but not high enough for diabetes. Approximately 30% of obese adolescents in the U.S. have prediabetes. Youth with prediabetes have significantly increased risk for developing type 2 diabetes. Literature demonstrates the significant impact of modest weight loss and physical activity on the prevention or delay of type 2 diabetes. Education on diabetes risk and initiation of lifestyle change is the primary treatment modality. Materials are needed to more effectively educate youth on diabetes progression and risk reduction while using consistent information from evidence-based behavior change methods.


General anesthesia is often preferred for dental surgery or rehabilitation in developmentally delayed pediatric patients. Bispectral index monitoring is used to monitor the depth of anesthesia and to ensure early recovery. However, studies on the topic in developmentally delayed pediatric patients are limited.


Grapevine (Vitis vinifera cv. Flame Seedless) was found infected with viral diseases; showing thicker leaves than normal, brittle, with margins rolled downwards and yellowish, which were identified as Grapevine Leaf roll-associated Virus-1 (GLRaV-1). Other symptoms were observed on leaves. The infected leaves showed malformation with abnormal gather primary veins, giving the leaf the appearance of an open fan, including yellowing and mosaic pattern on leaves, or bright yellow bands along major veins. Fan-shaped leaves were associated with mosaic or vein banding symptoms, these observations were identified as Grapevine Fan leaf Virus (GFLV). Both viruses were detected using Double Antibody Sandwich – Enzyme Linked Immuno Sorbent Assay (DAS-ELISA) and Reverse Transcription-Polymerase Chain Reaction (RT-PCR). The use of tissue culture was investigated as a mean to eliminate the two viruses. Virus-free plants were produced within six months using meristem tip culture. Woody plant (WP) medium supplied with benzyl amino purine BAP (4.44 µM) was used for shoot proliferation, and indole butyric acid IBA (0.2 µM) for plantlets rooting. Before acclimatization, the plantlets were submitted to DAS-ELISA and RT-PCR in order to evaluate virus eradication. GLRaV-1 and GFLV free plants (95 and 90 %, respectively) were obtained from the optimum size (0.5 mm) of meristem tips (as indexed by DAS-ELISA). Of these, 82.5 and 75 % plants were found negative for GLRaV-1 and GFLV, respectively, as diagnosed by RT-PCR. RT-PCR and meristem tip culture were found to be reliable methods for virus indexing and elimination of GLRaV-1 and GFLV.


The essence of nanotechnology is the design, creation and use of materials with at least one structure dimension in the range of 1 to 100 nanometers. Innovative applications of nanotechnology can provide benefits to society but also create risks for human health. The lack of an international agreement relating to legal regulations in the field of nanotechnology that would improve international trade, is due in particular to the lack of scientific knowledge about the risk associated with the use of nanomaterials and the numerous applications of nanotechnologies in various fields; this makes it difficult to cover nanomaterials with one comprehensive legal act. Ensuring the safe use of innovative applications of nanotechnology is, in particular, served by international soft law.


Objective: The purpose of this study is to prove whe theror not there is a relationship between the graduate academic average obtained by Public Accounting students during their degree studies, and the score obtained by these students in their general graduate exam (EGEL).
Material and methods: The study was conducte damong 47 Public Accounting students from the Unidad Zona Media of the Universidad Autonoma de San Luis Potosi, whose academic graduate averages and their scores obtained in their graduate general exam (EGEL)were analyzed. This information was taken from their school records, so that the statistical analyses consisting on the application of lineal regression techniques, not only simple but also multiple, with the gathered data, could be done.
Results: It has been proven that the graduates who reached higher grade point averages during their degree, also reached higher scores in the graduate general exams applied by Ceneval. The subjects that have the most direct correlation with their EGEL test scores include those from the fiscal area. These subjects a realso associated with the average grades that student sobtained throughout their program in field-related subjects, as well as in accounting-related subjects.


Most high-performance, scientific libraries have adopted hybrid parallelization schemes - such as the popular MPI+OpenMP hybridization - to benefit from the capacities of modern distributed-memory machines. While these approaches have shown to achieve high performance, they require a lot of effort to design and maintain sophisticated synchronization/communication strategies. On the other hand, task-based programming paradigms aim at delegating this burden to a runtime system for maximizing productivity. In this article, we assess the potential of task-based fast multipole methods (FMM) on clusters of multicore processors. We propose both a hybrid MPI+task FMM parallelization and a pure task-based parallelization where the MPI communications are implicitly handled by the runtime system. The latter approach yields a very compact code following a sequential task-based programming model. We show that task-based approaches can compete with a hybrid MPI+OpenMP highly optimized code and that furthermore the compact task-based scheme fully matches the performance of the sophisticated, hybrid MPI+task version, ensuring performance while maximizing productivity. We illustrate our discussion with the ScalFMM FMM library and the StarPU runtime system.


ABSTRACTAluminium alloys are used in advanced applications because their combination of high strength, low density, and durability. However, the properties of this material can be improved by using aluminium matrix composite materials. By reinforcing hard ceramic particles like SiC, Al2O3and B4C, TiO2 etc the strength of the composite can be enhanced. In this paper an effort is made to enhance the property of AMCs by reinforcing steel slag particle with A356 matrix. By varying the weight percentage of the steel slag the composite material was prepared through stir casting method. The mechanical property like hardness and impact strength of A356 was investigated and compared with that of composite material. The result reveals that by increasing the reinforcement percentage of steel slag the impact strength decreases with the increase in hardness of the composite material. The density is also compared with that of A356 composite.


Reply to the comment by L. Kofman, A. Linde and A.A. Starobinsky (hep-ph/9608341) to our article ``Analytic and Numerical Study of Preheating Dynamics'' (hep-ph/9608205).


High-alkali alumino-silicate glasses have excellent mechanical properties,especially in the hardness,toughness and resistance to scratch,it is the preferred protective material for touch screen of electronic information products.In this paper,temperature-viscosity curve was measured,the feasibility of producing ultrathin glass by float glass process.


Laboratory and industrial studies were carried out to investigate non-metallic inclusions in high strength alloy steel refined by high basicity and high Al_2O_3 slag.It was found that the steel/slag reaction time largely affected non-metallic inclusions.With the reaction time increased from 30 min to 90 min in laboratory study,MgO-Al_2O_3 spinels were gradually changed into CaO-MgO-Al_2O_3 system inclusions surrounded by softer CaO-Al_2O_3 surface layers.By using high basicity slag which contained as much as 41%Al_2O_3 in the laboratory study,ratio of low melting temperature CaO-MgO-Al_2O_3 system inclusions was remarkably increased to above 80%.In the industrial experiment,during the secondary refining,the inclusions changed in order of "Al_2O_3→MgO-Al_2O_3→CaO-MgO-Al_2O_3".Through the LF and RH refining,most inclusions could be transferred to lower melting temperature CaO-Al_2O_3 and CaO-MgO-Al_2O_3 system inclusions.


This research project was developed with the aim of strengthening the corporate culture and internal communication of the company Logic Studio located in the city of Quito and perform a communication proposal to increase the use of digital tools Business Communication. This project comprises two parts which are divided as follows: theoretical research in books that complement the variables raised Issue study. The field research that responds to the concerns raised in this thesis whereby studies performed in different scenarios that correspond to business performance in the research topic was considered as internal audiences population of Logic Studio. More than the survey interviews were generated to collect the desired information getting more visibility for the scope of this project. Finally a communications proposal is left raised for the faithful performance of the above at work and is complemented by seeking a solution to the problem of internal communication that the company Logic Studio and little interest in the use of digital communication tools are generated that are not exploited so that it generates more profit organization, in addition to recommendations, strategies, ideas which together a strategy that generates a better culture of communication between areas and between internal public in order to achieve defined be made corporate development to ensure success in the technology market.


Some commentators have tried to link Smith's analys is with fundamental results in economics of happiness. These contributions mainly focus on the influence of wealth on happiness (Ashraf, Camerer and Loewenstein, 2005; B runi, 2006; Brewer, 2009). However, this connection is far from covering Smith's consid erations about individual happiness and their possible similarities with today's analysis i n economics of happiness. In the Theory of Moral Sentiments , Smith asserts that adverse events depress people' s mind much more below their "ordinary state of happiness" than pros erous ones. However, close to what we call, today, "hedonic adaptations theories", he vie ws adverse and prosperous events as only short term shocks, so that an individual's level of happiness tends towards the one of his "ordinary state of happiness", just as short term m arket prices tend towards long term natural prices. This paper aims at throwing light o n the foundations of Smith's "gravitational" theory of happiness, on its consequ nces on an individual's preferences, and also on its implication with regard to the possibil ity of long-term variations of happiness. The first step leads to establish a link between th e nowadays familiar idea that individuals adapt to circumstances and Smith's analysis of indi v dual happiness. The second step puts to the fore the role that Smith grants to the sympa thy with the impartial spectator in the way back to the "ordinary state of happiness" after dev iations produced by prosperous or adverse events. At last, we focus on the decisional consequences that Smith draws from his gravitational theory of happiness, chiefly those wh ich deal with the choice between various permanent situations (for instance, poverty and ric hes) and their evaluation.


History of law showed that there was a legal mechanism to help mediation between a victim and an offender (criminal mediation)in an ancient society...


The majority of graph theory research on parameters involved with domination, independence, and irredundance has focused on either sets of vertices or sets of edges; for example, sets of vertices that dominate all other vertices or sets of edges that dominate all other edges. There has been very little research on "mixing" vertices and edges. We investigate several new and several little-studied parameters, including vertex-edge domination, vertex-edge irredundance, vertex-edge independence, edge-vertex domination, edge-vertex irredundance, and edge-vertex independence.