Nowadays, immunity treatment is becoming more and more important in the treatment of cancer. TAMs emerge as attractive targets for therapeutic strategies aimed at reprogramming their protumor phenotype into an effective antitumor activity. Evidence suggests that these TAMs actively promote all aspects of tumor initiation, growth, and development. Thus, tumors should not be treated as only aggregates of cancer cells but as separate structures. The altered ratio between Foxp3+ Tregs and Th17 cells plays an important role in the pathogenesis of immune-related diseases. We present an overview of mechanisms responsible for TAM recruitment and highlight the roles of TAMs in the regulation of tumor angiogenesis, invasion, metastasis, immunosuppression, and chemotherapeutic resistance. We also tried to describe the interplay between Th17 cells and other immune cells in the tumor microenvironment, and we assess both the potential antitumorigenic and pro-tumorigenic activities of Th17 cells and their associated cytokines. "We believe this knowledge will be of great interest to researchers who is working on TAM-targeting therapy as a promising novel strategy for an indirect cancer therapy.


ABSTRACT We study a group lasso estimator for the multivariate linear regression model that accounts for correlated error terms. A block coordinate descent algorithm is used to compute this estimator. We perform a simulation study with categorical data and multivariate time series data, typical settings with a natural grouping among the predictor variables. Our simulation studies show the good performance of the proposed group lasso estimator compared to alternative estimators. We illustrate the method on a time series data set of gene expressions.


It is a diicult task to distinguish legible digits from unsure patterns in connected handwritten digit recognition due to ambiguous character segmentation. In this paper, we rst present a new template presentation scheme based on a distance-to-boundary distribution for connected handwritten digit recognition. A neural network approach is then presented to extract templates based on this new presentation scheme, and a evolutionary algorithm based optimization algorithm is applied to nd the global optimized templates. In our approach, a template is presented by the distribution map of pixel distances to the boundary(s) between the foreground and the background, instead of the shape of a digit. A rational B-spline surface with a set of control knots is adopted to present each template. With 10,426 training samples from NIST Special Database 3 and 1,000 templates, this approach can successful reject 90.7% of unsure patterns while achieves 96:4% correct classiication on isolated digits.


Economic and financial markets interpenetrate and national economies are increasingly interdependent. This results in a growing need for comparability of accounting procedures internationally. Accounting for goodwill illustrates this phenomenon. By specifying the recommended asset treatment for purchased, positive goodwill, and the five-year amortization period, IASC has taken a significant step towards harmonization of goodwill accounting. As noted in the article, however, the implications for consolidated income may be quite drastic. This is especially so with respect to the implications of the revised IAS 22 (following IAS ED 32) for potential leveraged corporate buy-outs.


For the fi rst time the kinetic parameters of periodic growth of four strains associated bacteria of the genus Bacillus which are isolated from the underground organs of Dactylorhiza maculata, the representative of family Orchidaceae inhabiting temperate climate region, are studied for the purpose to defi ne the secondary metabolites synthesis time. At cultivation of bacteria in liquid cultures according with change of suspension optical density at 590 nanometers such parameters of periodic growth as duration of a growth phase, specifi c growth rate and generation time, the maximum exit of a biomass have been established. It was shown that all cultures grow with various rate and have the specifi c curves of growth which sometimes don't have a stationary phase. Comparison with growth curves of the same genus bacteria associated with tropical species Orchidaceae these is spent. Probable time of synthesis of secondary metabolites is defi ned for the studied microorganisms.


An intra-myocardial agent delivery device comprising a myocardial tissue access line that is configured to receive a pharmacological agent therein and at least a first agent delivery line having a central lumen therethrough, the first agent delivery line being in fluid communication with the tissue access line and including a plurality of dispersal lumens extending through the delivery line wall, wherein, when the first agent delivery line is disposed in myocardial tissue and the pharmacological agent is introduced into the tissue access line, the plurality of dispersal lumens allow the pharmacological agent to be transferred from the central lumen to the myocardial tissue.


The theory of health law being an independent law department cannot get comprehensive recognition for its defect.Seen from the attribute,origin and development of social law,health law should be classified into social law.Judging from the characteristics of health law,its legislative development condition and existing social crisis in health field,health law is an independent law department in social law domain,which realizes its content expansion and function intension for dealing with the existing social crisis.


Reserve currency role of USD and the expansionary monetary policies implemented since 2004 by FED opened a relatively favorable era which lasted almost ten years for the emerging countries. Turkey and Russia have been prominent emerging markets of Europe and substitutes of each other in terms of portfolio flows. This study plans to find the pull factors of each country that are dominant on portfolio flows in this ten years period. According to the VAR analyses, majority of the forecast errors of portfolio flows arises from the country risk premiums-CDS for each country. Yet, second most influential variables are the change in foreign exchange rate for Turkey and change in interest rates for Russia. The reasons behind that fact can be listed as difference between the current account balances, total saving rates, foreign exchange rate reserves, GDP growth rates and as a result level of dependency on portfolio flows.


e14149Background: Oncologists often need an objective, quantitative assessment of a patient's response to therapy. Lacking a standardized format, the oncologist may request a RECIST (Response Evalu...


The conventional Golden code consists of two pairs of Golden codewords, each being a combination of two input symbols. This paper proposes an enhanced bandwidth-efficient scheme for the Golden code (EBE-GC) based on quadrature amplitude modulation (QAM). We then derive the average bit error probability for the EBE-GC scheme. Simulations on bit error rates (BER) are carried out to verify the derived theoretical framework, where it is shown that the BER results lie well within the derived bounds. In addition, compared to the conventional Golden code with sphere detection, both 16QAM and 64QAM EBE-GC result in < 1 dB performance loss from a BER of 1×10−4.


As agriculture develops, courtyard-economy becomes thriving at present. In order to promote courtyard-economy's healthy development,the basic conception of courtyard-economy is presented,its superiority and inferiority are analyzed.It points out that courtyard-economy is one of mainstay country economy and an important mean of increaseing farmers' income. According to the characteristic of courtyard-economy, corresponding development countermeasures are brought forward.


Objective To investigate the effect of integrin-linked kinase (ILK) antisense oligonucletide (ASODN), which is complementary to ILKmRNA sequence, on the human gastric cancer cell line SGC-7901. Methods ILK ASODN was transferred into the gastric cancer cell line SGC-7901 by lipofectamine 2000. Then RT-PCR and Western blot were used to detect the changes of ILK mRNA and ILK protein expression after treatment. The rates of proliferation and apoptosis of the gastric cancer cell line SGC-7901 were studied by MTS assay and FCMS. Results The expression of ILK protein decreased after transfection, whereas the change of mRNA level was not notable. The cell proliferation was inhibited effectively and such inhibitory effect was dosage dependent. The apoptosis rate of the gastric cancer cell line SGC-7901 treated with ASODN increased strongly. Conclusion Transfer ILK ASODNs into gastric cancer cell line SGC-790 can effectively decrease the level of ILK protein expression, inhibit cell proliferation, and induce cell apoptosis.


Background: Out of hospital sudden cardiac arrest (SCA) is highly fatal, with estimated survival to hospital discharge 10-37%. The leading cause of death is neurologic injury, but with mild therapeutic hypothermia (MTH), favorable neurologic outcomes (NO) improve by 20%. Current guidelines recommend delayed prognostication for 72 hours post-SCA; our study aims to determine if early quantitative stratification of NO can be made using data available at hospital presentation. Methods: A retrospective chart review identified adult patients who received intravascular MTH for out of hospital SCA at a single institution from 2008-12 (n = 122). Patient demographics, pre-arrest diagnoses, resuscitation timing, and initial laboratory/imaging studies were compared between favorable and poor NO. As in landmark studies, favorable NO was defined as cerebral performance category (CPC) 1-2, poor 3-5. CPC assignment was made retrospectively by neurology using consultation and discharge physical exams. Univariate analysis was performed on all collected variables; those with ρ Results: 42 patients survived to hospital discharge (34%), 33 with favorable NO (27%). The final model included the following variables: age >45, CAD, non-VT/VF arrest, initial blood glucose >200, and initial pH Conclusions: This scoring system may allow for stratification of neurologic outcomes at hospital presentation and may identify a subset of patients who do not derive benefit from MTH and continued intensive care. Future multi-site, prospective investigation is needed.


The paper disccusses various models for discrete element methods of modelling particle shapes. The multi-sphere method is most frequently used, though a polyhedral approach and a hybrid sphero-polyhedral model can also be introduced. All above mentioned methods precisely approximate particle shapes, and difficulties in modelling contact between particles arise. Thus, there is a need to have an universal method that gives the analytical expression of the shape. For this purpose, spherical harmonics have been introduced. The article presents the concept of the spherical harmonics model and experimental results describing the cube-shape particle.


 Puff gun is the important installation in the oil-oxygen assisting weld system. This paper analyses the puff gun designed in taiyuan steel factory 50t arc furnace and calculates its main geometric parameters.


From novel H1N1 vaccines to improved retroviral treatments for persons with HIV/AIDS, novel health technologies have substantially improved health care in developed countries. Whereas in developing countries, major infectious diseases such as malaria, tuberculosis and HIV/AIDS as well as noncommunicable diseases (NCDs) remain prevalent, are the leading causes of death, and stand to benefit from postgenomics diagnostics enabled by data intensive Omics technologies [1-3]. Historically, aid to developing countries has been provided by governments and aid organizations for over 50 years in a number of forms that included the provision of health technologies, medicines, and training for health campaigns (e.g., immunization programs). However, despite decades of aid and the global health funding that keeps flowing, people are still dying. Indeed, little progress has been made towards eradicating poverty and improving healthcare access for the poor. In this editorial analysis, we argue that the benefits of pharmacogenomics and personalized medicine should be considered beyond a narrow focus on clinical medicine and in particular, in strategies of international development aid delivery in order to achieve greater effectiveness of global development aid.


This article examines 'parental harm' – a harm that occurs when a parent loses or faces the threat of losing a child. We contend that the manipulation and severing of relationships between parents and children has played a central role in war and oppression across historical contexts. Parental harm has long-term and pervasive effects and results in complex legacies for carers and their communities. Despite its grave impact, there is little research within International Relations into parental harm and understanding of its effects. We conceptualise parental harm through two frames – the 'harm of separation' and 'harm to the ability to parent' – and theorise gendered dimensions of how it is perpetuated and experienced. As such, we advance feminist understandings of family as a gendered institution that shapes the conduct of war and institutionalises racialised oppression. Our conception of parental harm offers novel insights into the relationship between intimate relations, the family, and state power and practices. We illustrate our conceptual arguments through two examples: the control and manipulation of family in antebellum slavery in the United States and the targeting of Tamil children in disappearances in Sri Lanka. These examples demonstrate the pervasiveness of parental harm across contexts and forms of violence.


The electronic device and the method of control is provided. If the control method of the electronic device is input, the user's voice, and to recognize the speech of the user, displaying a voice of the recognized user in the text input window with a text, and the user to cancel the entry of the displayed text cancel motion When the input, and displays the text to perform text input canceled at the cancel motion. As a result, the user becomes easier and easier to cancel the text entered through voice recognition.


The characters of Luling's writings share the insane personality.This article analyzes the insane personality of all the characters and the reasons of its formation.The author regards the insanity as a usual factor in Luling's writings,his novels expose the oppression and spiritual custody exerted by the feudal society on people.Therefore,insane personality does much help to make his novels more penetrative and tragic.


The invention provides a smart phone digital certificate application method and a smart phone digital certificate application system. The method comprises that: a certificate management module transmits a digital certificate application message to a certificate authority (CA) system, wherein the digital certificate application message comprises the certificate registration information of a smart phone user; the certificate management module receives a digital certificate response message returned by the CA system, and feeds a certificate downloading code back to the smart phone user, so that a smart phone can download the digital certificate according to the certificate downloading code from the CA system, wherein the digital certificate response message comprises a certificate downloading code of a digital certificate. By the smart phone digital certificate application method and the smart phone digital certificate application system provided by the invention, the certificate management module directly interacts online with the CA system, and receives the certificate downloading code from the CA system, and the smart phone user downloads the digital certificate from the CA system by adopting the downloading code, so the security of the certificate in use is greatly improved, and a support to the third-party digital certificate is realized.


We present the framework of "abstract perturbed Krylov methods", a new, unified point of view on different types of Krylov subspace methods. We give a brief informal sketch of polynomial representations of QOR approximations to solutions of linear systems and eigenvectors. The results are applicable to exact arithmetic, finite precision computations including semiduality approaches, and inexact methods. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)


This book review discusses 'The Mediated Presidency: Television News and the Presidential Governance' by Stephen J. Farnsworth and S. Robert Lichter. ISBN: 0 7425 3678 5.


The paper,depending on the methods of literature,questionnaires and comprehensive comparisons,discusses the disabled people's sports value,the theory of the basic public sports services for the disabled,the experience of foreign countries in the basic public sports services and the suggestions of strengthening China's basic public sports services for the disabled.The research believes that disabled people are of great value both to individuals and society.Disabled people's sports activities fall into the category of public services,so its development should be guided by the concerning theories of public services and foreign experience should be properly borrowed to boom its development.Finally the paper suggests the concerning measures to improve the basic public sports services for Chinese disabled people


Objective To explore the guiding role of continuous glucose monitoring system(CGMS) in treatment of glucose control in elderly T2DM patients.Methods Two hundred T2DM patients were randomized into groups CGMS and self-monitoring of blood glucose(SMBG).CGMS was performed in group CGMS,3d,and blood glucose detected in SMBG group.Treatments were adjusted according to glucose monitoring results.All patients wore CGMS for 3 d after 2 weeks.The glucose control was observed,and the fluctuations in blood glucose of CGMS group compared between pre-and post-treatments.Results In CGMS group,serum glycated albumin(GA),mean blood glucose level(MBG),mean amplitude of glycemic excursions(MAGE) were(17.0±2.9)%,(7.5±3.2)mmol/L,(3.2±1.0),respectively,significantly lower than in SMBG group((18.5±4.1)%,(9.9±3.0)mmol/L,(5.6±2.1),respectively).Posttreatment GA,MBG,MAGE significantly decreased as compared with pre-treatment in CGMS groups((21.8±5.0)%,(11.6±3.6)mmol/L,(5.5±1.1),respectively),the difference was significant(P0.05).Conclusion CGMS is superior to SMBG in glucose control in patients having received glucose adjusting.Fluctions in blood glucose is improved remarkably after treatment adjusting based on CGMS results.CGMS is an effective tool for improvement of glucose control.


The article is devoted to the research of the theoretical foundations of the decentralization process and the concepts of its role in the process of reforming the system of public authorities. The focus is on the theoretical basis for decentralization. The essence of the decentralization process is revealed, which consists, first of all, in the delegation of powers, authority and responsibility to the lower levels of government, semi-autonomous state organizations or private enterprises. At the same time, the central authorities reserve the right to influence and a number of powers, which are regulated during the conclusion of relevant contracts (agreements, contracts), maintaining the right to monitor the quality of services or delegated functions, make necessary adjustments (if necessary) or early terminate concluded agreements. It is established that the process of decentralization is based on the conclusions of economic theory and, as a rule, contains the following four theses: decentralization provides a more efficient allocation of resources in the public sector; decentralization contributes to the growth of accountability of public authorities in matters of spending budget funds; the availability of its own tax base encourages regional and local authorities to take measures to expand it, to encourage the development of regional and local economies; giving regional and local authorities the right to independently manage budgetfunds stimulates them to reduce unjustified expenditures in the public sector. It is determined that an example of the most complete form ofdecentralization, which can take various forms, is devolution. At the center of it idea is an increase in powers in favor of local governments.


Objective To assess the combination therapy with sodium hyaluronate, diprospan andultrashort wave on knee osteoarthritis in old patients. Methods The articular space of knee osteoar-thritis of 60 cases were injected with sodium hyaluronate (HA) 2 ml once a week. The pain spots ofsurrounding soft tissue of the knee joint were injected with diprospan 7 mg, VitB12 0.5 mg and 1%lidocaine once two week. Ultrashort wave was also used at the same time. One month was as a course.Observing the score of visual analogue scale (VAS) and joint motion function before therapy and one monthafter therapy.Result After one course, the pain of the knee joint was obviously reduced. The jointmotion function improved obviously. The total effectiveness rate was 96.7%. No side effect was observed.Conclusion The combination therapy with sodium hyaluronate, diprospan and ultrashort wave was aneffective way for knee osteoarthritis in old patients.


AIM: Atorvastatin is used along with a proper diet to help lower bad cholesterol and fats and raise good cholesterol in the blood. Objective: Difficulty in swallowing (dysphasia) is a common problem of all age groups, especially the elderly and pediatrics, because of physiological changes associated with these groups.


This article presents a study on different informative modalities of a percecptual supplementation device aiming at reducing overpressure at the buttock area. Visual, audio and tactile modalities are analysed and compared with a non-biofeedback session. In conclusion, modalities have a positive and equal effect, but they are not equally judged in term of comfort and disturbance with some other activities


In this paper we introduce local approximation spaces for component-based static condensation (sc) procedures that are optimal in the sense of Kolmogorov. To facilitate simulations for large structures such as aircraft or ships, it is crucial to decrease the number of degrees of freedom on the interfaces, or "ports," in order to reduce the size of the statically condensed system. To derive optimal port spaces we consider a (compact) transfer operator that acts on the space of harmonic extensions on a two-component system and maps the traces on the ports that lie on the boundary of these components to the trace of the shared port. Solving the eigenproblem for the composition of the transfer operator and its adjoint yields the optimal space. For a related work in the context of the generalized finite element method, we refer the reader to [I. Babuska and R. Lipton, Multiscale Model. Simul., 9 (2011), pp. 373--406]. We further introduce a spectral greedy algorithm to generalize the procedure to the parameter...


From the bark of Lunasia arnara BLANCOvar. refmnda (LAUTERB. et K. SCHUMM) LAUTERB. (New Guinea) were isolated apart from the known Rutaceae alkaloids hydroxylunidine (I), hydroxylunacridine (II), lunacrine (111) and lunacridine (IV) two new crystalline alkaloids. One of these differs from I only by the absence of the tertiary hydroxyl group in the side-chain and was therefore named lunidine (V). The other one (VIII) is a ketone also obtained by oxidation of the hydroxyl group of lunidine. We therefore named it lunidonine.


With reference to statistics data available,the author analyzes from multi-angles the wave-characteristics and structure characteristics of the Chinese aviation logistics services and conditions on which it develops,aconclusion is made that the Chinese aviation logistics industry is still experiencing its growing-up period,the seasonality of air-cargo transportations differs from that of passengers transportations.The business of air-cargo services are heavily concentrated in three areas in China with the most robust,booming economic development,a pattern is therefore formed that it is too busy in the south,whereas relatively lighter in the north.A perspective can be seen in this paper about the changing conditions and momentum of the Chinese aviation logistics.


In this paper, we introduce and investigate multi subspacehypercyclic operators and prove that multi-hypercyclic operators are multi subspace-hypercyclic. We show that if T is M -hypercyclic or multi M -hypercyclic, then Tn is multi M -hypercyclic for any natural number n and by using this result, make some examples of multi subspacehypercyclic operators. We prove that multi M -hypercyclic operators have somewhere dense orbits in M . We show that analytic Toeplitz operators can not be multi subspace-hypercyclic. Also, we state a sufficient condition for coanalytic Toeplitz operators to be multi subspace-hypercyclic.


This paper presents the design, fabrication process, experimental characterizations and simulations of a novel passive micro gas regulator. The device is to be used in a miniature fuel cell for portable electronic applications in order to regulate the hydrogen flow feeding the fuel cell from a high-pressure tank. Its structure and working principle are similar to some macroscopic devices. Using MEMS technologies, e.g., deep-RIE etching and multiple wafer bonding, the dimensions of the device have been made less than 8 × 8 × 1 mm3. Moreover, as it is passive, it consumes no power from the fuel cell. Thanks to these two features, it is well suited for portable applications. To our knowledge, this is the first passive micro gas regulator, except those actuated by hydrogels. The experimental characterization shows that the opening and closing are controlled by the released gas pressure. Up to an input pressure of 8 atm, the device has been successfully driven and the leakage has been measured to be below 0.1 sccm nitrogen. Analytical models for the moving part and for the flow rate show a good agreement when compared to the experimental data.


Abstract The notion that individuals differ in their physical and psychical makeup, and that these differences predispose them to various illnesses, is found throughout medical history in various healing traditions. In this paper, the authors address the use of the concept of constitution and constitutional type in homoeopathy, as well as in psychiatry, and describe an approach toward validating the existence of such types in the population.


Text: This work deals with the modeling and the numerical simulation of the carbon dioxide (CO 2 ) absorption, coupled with a chemical reaction, in an initially quiescent aqueous alkaline solution, inside a Hele-Shaw cell. Such a cell is a commonly used experimental tool to study the CO 2 transport phenomena in porous media, especially in the framework of CO 2 sequestration in deep saline aquifer processes. In our device, the liquid fills partially the gap between two parallel transparent Plexiglas plates. CO 2 is forced to flow above the liquid in the cell and, therefore, it is absorbed in the liquid, in which it takes part to chemical reactions. In previous works, two kind of aqueous alkaline solutions have been experimentally studied thanks to a Mach-Zehnder interferometer (enabling the visualization of liquid density variations): a solution of monoethanolamine (MEA) and a solution of a mixture of sodium carbonate (Na 2 CO 3 ) and bicarbonate ), hereafter solution 1 and 2, respectively. variation of the CO 2 pattern triggering the instability and that the simulated instability dynamics agree qualitatively with the experimental observation for the two considered solutions. Thanks to the simulation result analysis, the discrepancies of the instability dynamics are partially explained and their effect on the mass absorption is evaluated. It is shown that this rate may be not enhanced by the instability, contrarily to what is commonly expected. Title: Numerical Study of Buoyancy-Induced Instability during CO2 Absorption in Alkaline Solutions


"BreastGAN: Artificial Intelligence-Enabled Breast Augmentation Simulation" written by Dr Chartier et al focuses on cutting-edge breast augmentation technology.1 I did some early research 15-20 years ago in three-dimensional (3D) imaging—in which laser scanning and reverse engineering computer-aided design (CAD) software were utilized to build models for breast augmentation. This article describes a significant step forward in terms of both computing power and ease of technological use, while also using very straightforward technology we are all familiar with. It uses standardized photography, possibly even photography taken with a smartphone. It then uses a neural network—without requiring significant manual work after the dataset is created—to help generate a possible future surgical result. The authors should be commended for their contributions regarding our ability to utilize the technology at our disposal to help create novel ways of providing patients with a better understanding of possible postoperative outcomes (Video). While the article is a great first step, there are certainly a broad variety of limitations to utilizing this technology in the clinical arena at the moment. Importantly, all the photographs used in the article and for the dataset to help create postoperative images were from only one surgeon and did not have information based on implant sizing. Furthermore, all the images are only frontal images. Patients are often very interested in postoperative results from many different applyparastyle "fig//caption/p[1]" parastyle "FigCapt" applyparastyle "fig" parastyle "Figure"


Beluntas leaves (Pluchea indica L.) have been known as analgetic reducer. The study about this research has been going on right now. The goal of this research is to study the analgesic effect of beluntas (P. indica) leaf infused into male mice of swiss strain. The method used is the stretching chemical stimuli using acetic acid as an inducer of pain. Healthy male mice of Swiss strain were divided into five groups, and each group consisted of 5 mice. Group I was given paracetamol at a dose of 65 mg/kg of body weight, group II were given distilled water , the group III-V were given beluntas leaf infuse in the variation of 10 %, 20 % and 40 %. Thirty minutes after test substance application, acetic acid of 100 mg/kg of body weight were given intraperitoneally in all groups and stretching of mice was observed every 5 minutes for 1 hour. The data was analyzed by using normality test of Kolmogorov-Smirnov; the  test of homogeneity of variance was analyzed by ANOVA and post hoc tests were to differenciate the percentage analgetic of every group. Statistical test showed normal distributed and homogeneous data; there are significant differences of percentage analgesic between paracetamol and beluntas leaf infuse of 10, 20, and 40 % (p < 0.05). There was significant differences between infuse of beluntas leaves with positive control (parasetamol) in mice. Key words: Analgetic, leave of beluntas (P. indica), infuse, mice.


This autoethnography elucidates the challenges I encountered in my efforts to maintain my commitment to leadership for social justice. When I assumed the superintendency of a small rural school district in southern Texas, I started collecting data in the form of a journal. My lived experiences, as recorded in my journal, were the sole source of data for this inquiry. This study provides a descriptive analysis of my daily experiences as a first-time superintendent. Due to time limitations, this project focuses only on the first year of my superintendency, giving particular attention to the political and social factors that impeded my philosophy of social justice.


Abstract The sporophores of Gyrodon lividus contain (-)-cha-monixin and (-)-involutin, indicating the close relationship of Gyrodon to the Paxillaceae and Gyroporus.


In a conventional Network-on-Chip (NoC) system, a processing element (PE) is to serve only an application task in a fixed time interval. When an application task is allocated to a PE, the PE is thus blocked by the application, even though it is not used by the application all the time. This would lead to a waste of computing resources, which also becomes a bottleneck of performance enhancement. This work tries to solve the above issue by proposing a service-oriented architecture (SoA) design for virtualization in NoC. The proposed SoA design supports Partial Reconfigurable Region as a Service (PRRaaS) and Processing Element as a Service (PEaaS) for varying applications. According to the requirements of software applications, new PEs can be created on-demand by (re)configuring the logic resource of PRRs in the FPGA, while the configured PEs can also be virtualized to support multiple application tasks at the same time. Experimental results show that, although additional logic resources are required, the SoA design can reduce up to 47% of the total processing time required by using the conventional Hermes NoC design.


Kinetic Theory of Granular Flow (KTGF) has been successfully incorporated and widely implemented in the Eulerian simulation models in many multiphase cases. The KTGF theory involves many parameters and is applied in the multiphase simulation for the purpose of hydrodynamic properties modeling of the granular phase. This paper is focused on granular viscosity which is a parameter in the KTGF that incorporates three different viscosities arising from the inter-phase and intra phases interaction in a bubbling fluidized bed (BFB). The 2D BFB model of 0.2 m width and 0.8 m length having a 13-hole orifice plate has been modeled for this purpose. The model was constructed using Gambit software version 2.4.6 and then simulated using ANSYS Fluent version 14. Two models of granular viscosity, namely Syamlal-Obrien model and Gidaspow model, were compared based on its effect to the pressure drop and bed expansion of the BFB. The results depicted that the simulation based on Syamlal-Obrien model tends to produce larger bubbles and contributing to a higher pressure drop across the distributor plate as compared to the Gidaspow model.


We present observations in eight wavebands from 1.25 to 24 μm of four dense cores: L204C-2, L1152, L1155C-2, and L1228. Our goals are to study the young stellar object (YSO) population of these cores and to measure the mid-infrared extinction law. With our combined near-infrared and Spitzer photometry, we classify each source in the cores as, among other things, background stars, galaxies, or embedded YSOs. L1152 contains three YSOs and L1228 has seven, but neither L204C-2 nor L1155C-2 appear to contain any YSOs. We estimate an upper limit of 7 × 10−5 to 5 × 10−4L☉ for any undiscovered YSOs in our cores. We also compute the line-of-sight extinction law toward each background star. These measurements are averaged spatially, to create χ2 maps of the changes in the mid-infrared extinction law throughout our cores, and also in different ranges of extinction. From the χ2 maps, we identify two small regions in L1152 and L1228 where the outflows in those cores appear to be destroying the larger dust grains, thus altering the extinction law in those regions. On average, however, our extinction law is relatively flat from 3.6 to 24 μm for all ranges of extinction and in all four cores. From 3.6 to 8 μm, this law is consistent with a dust model that includes larger dust grains than the diffuse interstellar medium, which suggests grain growth has occurred in our cores. At 24 μm, our extinction law is two to four times higher than predicted by dust models. However, it is similar to other empirical measurements.


The basis of electronic transaction is the free will from everyone who bind himself to others, without coercion from any party, and without the necessity to meet directly. This requires regulations other than the existing law as guidelines for the perpetrators. The agreement is made under lex Informatica, particularly the rules made and agreed upon by the parties in electronic transaction. This article is written to discuss the use of lex Informatica concerning the self-regulation approach carried out along with its examples of electronic transaction in Indonesia. The focus of the discussing is about the benefits of using lex Informatica in electronic transaction and the relation between lex Informatica and self-regulation as theory and approacch in electronic transaction. This study using juridical normative research methods, and descriptive-analytical specifications, through library research and field studies. The results obtained indicate that lex Informatica as a fondation law in internet can underlying an agreement between the parties regarding matters that are not regulated in statutory regulations and self-regulation relating to lex Informatica can be as a regulatory model that provides an opportunity for parties to regulates electronic transaction activities.


T H E I N H E R E N T fascination of Vienna's contribution to modern cultural life as well as Carl Schorske's considerable erudition and limpid style insure that Fin de siecle Vienna: politics and culture will be widely read and discussed; however the limitations of Schorske's perspective on Vienna at the turn of the century are sure to disappoint those scholars who have been anticipating a definitive work on the subject from him for the last two decades. The temptation, then, will be for neophytes to overvalue the book, while scholars working in the field will tend to underestimate the value of Schorske's work *. Of the seven essays collected in the volume four have been in print for some time. The first of these, 'Politics and the Psyche', treats Vienna as the locus for the transition from what Schorske terms 'moral-scientific' middle-class culture to decadence, i.e. the supplanting of scientific rationality by narcissism as an ideal or, what comes to the same thing, the abandonment of a socially engaged, historically informed conception of human nature in favor of one which is egocentric and psychoanalytical. Arthur Schnitzler's writings are taken to embody the former while the young Hofmannsthal stood for the latter. Schnitzler's significance for the period is rightly emphasized by virtue of the fact that he had one foot in each world, so to speak, and thus was able to depict the conflicts between these two cultural ideals graphically and poignantly. The second of the older essays, 'Politics in a New Key', depicts the emergence of the political counterpart of Viennese narcissism in the political fantasies which infused vitality into Viennese mass politics as it emerged in Karl Lueger's Christian Social movement with its opportunistic exploitation of popular anti-semitism, Georg von Schonerer's fanatical German Nationalism and Herzl's Zionism in the wake of the failure of Viennese liberalism. The third essay, 'Politics and Parricide in Freud's Interpretation of Dreams', offers a fascinating account of the historical origins of Freudian theory in the political frustrations of the Viennese middle class by examining Freud's personal frustrations in the light of the aspirations and failures of his father's generation. The fourth of the older essays, perhaps the profoundest of the seven, 'The Transformation of the Garden' brilliantly analyses the complex social and aesthetic phenomena surrounding the metamorphosis of art from an embellishment upon social life into the very reason for living as reflected in the changing role of the garden as a symbol in the writings of Adalbert Stifter, Ferdinand von Saar, Leopold von Andrian-Werberg and Hugo von Hofmannsthal.


Two-dimensional systems with $U(1)$ symmetry exhibit a peculiar phase, i.e., the Berezinskii-Kosterlitz-Thouless (BKT) phase. In particular situations, the BKT phase exists as an intermediate-temperature phase. There have been scenarios for the phase transitions at the two end points of the intermediate BKT phase; i.e., the phase transition at the low-temperature end point is a BKT transition and that at the high-temperature end point is either a BKT transition or a first-order transition. The present study gives a novel scenario, i.e., a second-order transition with a new critical universality and a BKT transition. We found that this new phase transition is realized in spin-crossover systems on a triangular lattice with an antiferromagnetic short-range interaction. At the low-temperature transition the elastic interaction plays as a ferromagnetic infinite-range interaction and encourages the breaking of ${Z}_{2}$ symmetry between high-spin-rich and low-spin-rich states.


The invention provides a pressurization system for an internal combustion engine, belonging to the technical field of heat engine. The pressurization system mainly comprises a low-pressure gas compressor, an air turbine, a high-pressure gas compressor, a high-pressure turbine, an intercooler and an internal combustion engine. The low-pressure gas compressor is coaxially connected with the air turbine; the high-pressure gas compressor is coaxially connected with the high-pressure turbine; an outlet of the intercooler is communicated with an inlet of the air turbine; and an outlet of the air turbine is communicated with a gas inlet channel of the internal combustion engine. Besides being coaxially connected with the low-pressure gas compressor, the air turbine can also be connected with a generator or a crankshaft of the internal combustion engine. The pressurization system can lower the gas inlet temperature of the internal combustion engine, so as to reduce the nitrogen oxide emission of the internal combustion engine and inhibit the occurrence of gasoline engine knock. Besides driving the coaxial low-pressure gas compressor, the air turbine can also be used as a power device for outputting power to the external.


Soil arching is one of the fundamental phenomenon in geotechnical engineering, and is relied upon when constructing column supported embankments on soft soil sites. This research outlines a modelling approach to allow for the improved simulation of soil arching in column supported embankments. The modelling approach is validated against recent experimental studies before being applied to extend the understanding of soil arching. The findings have implications for the theoretical understanding of soil arching, future experimental studies and the practical design of column supported embankments.


In recent years, as AI technology has advanced, online monitoring of dams has garnered increasing interest. In addition, surrogate model technology is a crucial component of online monitoring. As a result, developing a high-quality surrogate model has become one of the pillars of dam online monitoring. This work proposes a local radial basis function based on sensitivity modification to address the deficiencies of the current radial basis function. In addition, a benchmark function is utilized to validate the method's viability. Comparisons with BP neural network and RBF demonstrate the usefulness of the proposed strategy. The analysis demonstrates that the proposed strategy for constructing a surrogate model of the dam's structural behavior is possible and accurate. This paper aims to establish a high-quality surrogate model to provide technical support for dam online monitoring.


Abstract We discuss the stability of the steady state solutions for an isentropic hydrodynamic model of semiconductors of two species. We consider not only the mass and momentum equations for electrons, but also those two equations for holes. The recombination effects between electrons and holes are taken into consideration as well. We study the case where the doping profile is close to zero and depends on the spacial variable x . We shall show that steady state solutions are asymptotically stable.


In the course of one of the Saturday evening excursions of the Heriot-Watt Geology Class in the spring of the present year (1893), the rocks now being exposed in the new railway cuttings to the west of Davidson's Mains were studied in some detail. The sedimentary rocks outcropping there are of Lower Carboniferous age, and appear to correspond in geological position with the highest beds of the Granton Sandstone, together with the lower part of the overlying Wardie Shales. Their prevailing dip is westward. At this point these rocks have been invaded by a sheet of igneous rock forming part of the intrude of the Corstorphine Hill, and whose bounding surface nearly follows the bedding of the sedimentary rocks. In its outer parts the rock at Barnton consists of a holocrystalline aggregate of plagioclase felspar, and pyroxene, combined in about equal proportions; together with ilmenite, a serpentinous mineral, and some leucoxene. It shows well-marked ophitic structure, and is, therefore a dolerite. The central portion of the mass is different in both structure and composition. It consists of a holocrystalline compound of olivine (and of serpentine representing that mineral), pyroxene, brown mica, and an ore of iron. Felspar occurs in either small proportion or is absent entirely. The structure of the aggregate is granitic; this part of the rock, therefore, is a picrite. Here and there the picrite itself is traversed by segregation-veins, which are, as usual, of a more acid composition than the mass, and which agree closely in character


Achievement of reliable technologies on solidification and disposal of the HLW from future fuel cycle systems such for high burnup LWR, Pu-thermal (MOX), fast breeder reactor (FBR) and their transient stages is one of the most important issues to establish such advanced fuel cycle systems. In this paper, applicability and flexibility of the current vitrification technology for LWR fuel cycle to HLW from the future fuel cycle systems were reviewed by examining characteristics of the HLWs. The current developed vitrification technology is expected to have an advantage for applying to the solidification process of the HLW generated from future fuel cycle systems with some modification/optimization of the melting condition, etc. Moreover, it is thought that the advance aqueous reprocessing system developed for future FBR cycle has the potential which can contribute to the further reducing the number/volume of the HLW. It is also confirmed that development efforts on countermeasure for accumulation of noble metals, which JAEA has been carrying out aiming to accomplishing more stable and reliable operation of the vitrification process and extending the melter's life, will be able to contribute in the future fuel cycle system furthermore.


A method of conducting perfusion, by which the patient's oxygen consumption (V̇O2) is always being maximized, is presented. The endpoint of good perfusion is argued to occur when V̇O2 plateaus despite further increases in cardiac index, haemoglobin concentration, arterial oxygen delivery, or pharmacological intervention. Thus, this method quickly assesses the patient's varying oxygen demands, reduces metabolic acidosis, and enhances oxygen distribution.
Determination of V̇O2 was done with in-line oxygen sensors (Critikon) and a handheld programmable calculator (Texas Instruments Model 59). No nomograms or tables are necessary and the time required is less than 80 seconds.
Exemplary cases demonstrate the value, cost effectiveness, and simplicity of the V̇O2 plateauing method. The dependence upon conventionally used perfusion parameters such as venous saturations, flows, pressures, and urinary output are refuted.


Background: Multiple myeloma (MM) is a blood cancer type affecting plasma cell in bone marrow. MM is heterogenous in nature but t(11;14)(q13;q32) translocation is a common prognostic marker among MM patients. One of the most frequent oncogenic drivers involved in this chromosomal rearrangement is CCND1 (Cyclin D1) gene translocation downstream to the immunoglobulin heavy chain (IGH), which results on overexpression of CCND1, thus promoting abnormal cell proliferation. Oncogenic CCND1 RNA levels can result from translocations such as t(11;14), gene amplifications, increased transcription rates and/or RNA stability. Indeed, CCND1 RNA overexpression has a favorable prognostic value for patients treated with high doses of chemotherapies but important challenges remain in accurate detection of CCND1 RNA levels. Currently, FISH is the gold standard method for detecting t(11:14) translocations at the DNA level. However, it cannot detect CCND1 overexpression. Therefore, a method that can detect CCND1 overexpression levels, as well as in frame transcripts has clinical implications. In the current study we leveraged in-use NeoGenomics Heme TNA single tube NGS assay to enable the detection of CCND1 RNA overexpression as a complementary test to FISH testing.
 Methods: We performed RNA sequencing from 32 healthy donors and on fixed cell pellets from 94 CD138-enriched BM samples from MM patients and from using the amplicon based (Qiagen, inc) NGS assay. We developed pipeline for gene expression by TPM count (transcript per million) for CCND1, and further normalized to the "housekeeping" gene GUSB. We validated the normalization to GUSB by comparing to normalization using the geometric mean of four housekeeping genes (GUSB, PGD, RPL5 and RPL19) showing a high correlation (R 2>0.95). A commercially available qRT-PCR assay was used as orthogonal method to further confirm the linearity of the quantitative gene expression signal in NGS. The analytical cutoff was determined from normalized TPM calculation from 32 healthy volunteers following CLSI guideline (CLSI_EP17-A2) and further updated from MM-PCE samples with t(11:14) translocations from a CLIS-validated FISH assay .
 Results: From 94 CD138-enriched BM samples, 26 had t(11:14) translocations, or CCND1 gains as detected by FISH, 15 samples were confirmed negative by FISH and 32 normal volunteers with no suspected disease. Also, we determined the analytical cutoff for CCND1 overexpression based on the CLSI guidelines to be 2.37 times the expression level of GUSB ("housekeeping" gene) using normal volunteers (n=32) (sensitivity 86% and specificity 77%). We found specificity to be low, so further evaluated the threshold using a ROC curve analysis with multiple tests. Using Fischer's exact test, we found CCND1 expression 3.27 times the GUSB expression to yield higher specificity of 86.5 % and sensitivity for 78.9%. Further, we used 26 FISH positive and 32 normal samples to build a new model and determined the cutoff for CCND1 overexpression to be 4.15 times GUSB expression, which resulted lower sensitivity but higher specificity (75% sensitivity and 100% specificity). When we evaluated 15 FISH negative samples with this cutoff we observed CCND1 was not overexpressed in six samples, but 9 samples did have some degree of overexpression. Overexpression was confirmed by qRT-PCR. Two CCND1 high- and low- expressing normal samples (MM-PCE 27 and 48) were further evaluated using alternative extraction methods to test the dependencies on extractions and the data showed concordant to each other for overexpression. Interestingly, 1 sample (MM-PCE-27) showed very high overexpression without t(11:14) translocation event (~100 fold over expressed). Cytogenetic studies were discordant with FISH as well for this sample, showing abnormalities related to chr7q,13q,12p but no indication of any chr11 related event.
 Conclusions: In this study we evaluated our existing NGS assay for CCND1 overexpression using TNA as a surrogate for traditional FISH, while demonstrating the accuracy of the RNA quantitation by NGS using qRT-PCR. We developed an RNA-seq based CCND1 expression assay that could be used to complement traditional FISH testing especially if there is limited specimen. The confirmation of overexpression in FISH negative samples may suggest new ways to improve MM patients risk stratification and treatment.

 Ghosal: NeoGenomics Laboratories: Current Employment. Alarcon: NeoGenomics Laboratories: Current Employment. Koo: Neo Genomics Laboratories: Current Employment. Kang: Neo Genomics Laboratories: Current Employment. Ramesh: Neo Genomics Laboratories: Current Employment. Gyuris: Neo Genomics Laboratories: Current Employment. Jung: NeoGenomics Laboratories, Inc.: Current Employment. Thomas: NeoGenomics Laboratories, Inc.: Current Employment. Fabunan: NeoGenomics Laboratories, Inc.: Current Employment. Magnan: NeoGenomics Laboratories, Inc.: Current Employment. Nam: NeoGenomics Laboratories, Inc.: Current Employment. Petersen: Neo Genomics Laboratories: Current Employment. Lopez-Diaz: NeoGenomics Laboratories, Inc.: Current Employment. Yamahata: Neo Genomics Laboratories: Current Employment. Bender: NeoGenomics Laboratories, Inc.: Current Employment. Agersborg: NeoGenomics Laboratories, Inc.: Current Employment. Ye: Neo Genomics Laboratories: Current Employment. Funari: NeoGenomics Laboratories, Inc.: Current Employment.


In this paper we present a novel approach to decomposing high dimensional spaces using a multiobjective genetic algorithm for identifying (near-)optimal subspaces for hierarchical classification. This strategy of pre-processing the data and explicitly optimising the partitions for subsequent mapping onto a hierarchical classifier is found to both reduce the learning complexity and the classification time with no degradation in overall classification error rate. Results of partitioning pattern spaces are presented and compared with various algorithms.


The title compound, [Co(C2H8N2)3]2[SiMo8V4O40(VO)2]·6H2O, was prepared under hydrothermal conditions. The asymmetric unit consists of a transition metal complex [Co(en)3]3+ cation (en is ethylenediamine), one half of an [SiMo8V4O40(VO)2]6− heteropolyanion, two solvent water molecules in general positions and two half-molecules of water located on a mirror plane. In the complex cation, the Co3+ ion is in a distorted octahedral coordination environment formed by six N atoms of the three chelating en ligands. One of the en ligands exhibits disorder of its aliphatic chain over two sets of sites of equal occupancy. The [SiMo8V4O40(VO)2]6− heteropolyanion is a four-electron reduced bivanadyl-capped α-Keggin-type molybdenum–vanadium–oxide cluster. In the crystal, it is located on a mirror plane, which results in disorder of the central tetrahedral SiO4 group: the O atoms of this group occupy two sets of sites related by a mirror plane. Furthermore, all of the eight μ2-oxide groups are also disordered over two sets of sites with equal occupancy. There are extensive intermolecular N—H⋯O hydrogen bonds between the complex cations and inorganic polyoxidoanions, leading to a three-dimensional supramolecular network.


This study aims at shedding light on the linguistic significance of collocation networks in the academic writing context. Following Firth's principle "You shall know a word by the company it keeps." The study intends to examine three selected nodes (i.e. research, study, and paper) shared collocations in an academic context. This is achieved by using the corpus linguistic tool; GraphColl in #LancsBox software version 5 which was announced in June 2020 in analyzing selected nodes. The study focuses on academic writing of two corpora which were designed and collected especially to serve the purpose of the study. The corpora consist of a collection of abstracts extracted from two different academic journals that publish for writers from different countries around the world. This corpus-based study aims at examining the significance of chunks of language in texts. The concept of collocations is crucial in corpus linguistics to identify semantic relations. This can help in the teaching and learning processes. Furthermore, this study is conducted to answer the following research questions; first, whether the three words study, paper, and research are used interchangeably in the corpora or not? Second, what are the shared collocational associations surrounding the selected nodes? Finally, it is worth noting that the study of collocations highlights the linguistic features of texts through computational analytical tools that can save time and help to gain objective results systematically. The findings show that 'research' and 'study' are used rather interchangeably in the writing of the abstracts; however, 'paper' has fewer shared collocations in the same academic context.


Kid's Catalog Vendor: CARL Corporation 3801 East Florida Avenue, Suite 300 Denver, Colorado 80210 (303) 758-3030 Fax: (303) 758-0606 Internet: firstname.lastname@example.com Demo Available: Yes Version: 1.39 for Windows; 1.42 for the Macintosh No. of Customers: 300 sites, approximately 1,000 installations Prices: $500 per workstation; quantity discounts available PRODUCT REQUIREMENTS Micro: 33 MHz 486+ PC with 4 MB of memory, 1 MB video card, and a color monitor are recommended Operating System: Windows 3.1+ or Macintosh System 7.0+ LANs Supported: Any Windows or Macintosh compatible network EASE OF USE Average 1 2 3 4 5 6 7 Simple and Natural Dialog 6 Minimum User Memory Load 6 Consistency 6 Feedback 6 Shortcuts 6 Error Prevention 6 Overall Rating 6.0 FEATURES Kid's Catalog is a graphical user interface-based online public access catalog (OPAC) designed specifically for children and young adults. It is not a Z39.50 compliant product but the following vendors have developed an interface to it. CARL, Ameritech Library Services, Geac, Gaylord, Sirsi, and COMPanion. As a client in a client/server environment, Kid's Catalog needs to be connected either to the local library's automated library system or the Internet. After making the connection to a requested database, Kid's Catalog displays six large icon buttons in its welcome window as shown in Figure 1. These represent the following.. Type Search, Explore, Find It, Best Stories, Help, and Events. Clicking on the Type Search icon will open up a window that allows the user to enter or "type" a search request. After doing so, the user can click on either the Author, Title, or Words button to indicate and initiate the search-see Figure 2. Entering a word search for "library" retrieved 1,157 records at the Denver Public Library, but many of these records were retrieved because they had the term "library" in the series statement. While the software does not inform the user, a branch needs to be selected to return correct status information. Thus, the message Not available, try `More Libraries' " or a Call Number of "Ask a librarian for help" was displayed. Puzzling for the less knowledgeable user. Clicking on the Explore button opens up a window with a number of colorfully labeled icons, e.g., Famous People, History, Countries, Science, Machines, Nature, Animals, etc., as shown in Figure 3. Clicking on a particular one will display a scrollable list of brief citations related to it-see Figure 4. The brief citation gives the title, author, and call number in a blue font against a gray background. Single clicking on a citation opens a window that displays the full record. The right-justified data labels are shown in a blue font@ the variable text is displayed in a black font; and status information is shown in red. To the right of the bibliographic record is a Map icon. Clicking on it will display a map of the library and give the user an indication of where to find the item being searched. …


Information of water pollution can be timely provided by rapidly detecting water toxicity, which is the basis of dealing with pollution incidents and the warning system of water quality.Rapid assays for water toxicity are mainly based on luminescent bacteria, chemical luminescence, respiration inhibition, photosynthesis decrease and electrochemical detection technology.In the present paper, it was reviewed that the main principle and technology of rapid assays for water toxicity and its development trends.


The critical behaviour of a three-dimensional Ising model, bounded by two plane surfaces meeting at an angle alpha , is studied using the Migdal-Kadanoff and two-terminal cluster renormalisation methods. The authors obtain expressions for the edge fixed point and for the independent edge exponent yhe at the various transitions. They find that yhe is not completely universal but depends on the angle alpha , and that it shows some unexpected features.


Abstract Trends in Internet infrastructure indicate that organizations with mission-critical needsare outsourcing applications to a small number of Internet data center providers. Theseproviders operate networks and services at a global scale, and offer customers (and otherservice providers) a variety of services ranging from high bandwidth networking to full-fledged application hosting and IT management services. These global service providersoffer their services through large data centers. Each will eventually contain 10,000-50,000 servers with high-speed network connections to other data centers and theInternet. The large scale and rapid evolution of these data centers offers significantchallenges for the data center operators. This paper describes issues that face data centersas they scale in size and our current research to support such scalability. It explains ourapproach to: introduce greater numbers of applications into these environments, supportautomated management, and make it attractive for organizations to outsource the hostingof greater numbers of applications.


An estimation of ground heat flux for two locations has been done using temperature gradient method. Effective media approach has been adopted for predicting the effective thermal conductivity of ground. For comparison, in situ measurement of effective thermal conductivity of ground has also been done by thermal probe method. The measured values of thermal conductivity are in agreement with the calculated values. The estimated values of ground heat flux have been used to evaluate the melt rate at ground-snow interface.


Abstract This research provides the first-ever quantitative account of British university athletes' attitudes toward having a gay male teammate. We use a four-year longitudinal study to investigate athletes' attitudes concerning gay men in their sporting spaces. Using questionnaires of 216 male athletes from all university sports offered upon entry (2006), and then again upon exiting the university (2009), we show that attitudinal dispositions of homophobia have decreased from minimal (upon entrance) to non-existent (upon exit). We find that the strength of one's athletic identity is associated with lesser degrees of support for gay teamsport athletes upon entering the university, but that this effect does not emerge upon exiting. We highlight the study's results, situating them within inclusive masculinity theory, and discuss how results might vary at other institutions.


We investigate the target stock price run-up prior to M&A announcements between 1981 and 2011. About one third of the total price run-up occurs before announcements, and the pre-announcement run-up does not seem to be caused by market anticipation of M&As, toehold acquisitions or reported insider trading. Instead, the pre-announcement run-up is significantly larger when media attention on insider trading is lower, when institutional ownership is lower, and when probability of informed trading is higher. The findings are consistent with the view that the target stock price run-up prior to M&A announcements is caused by unreported insider trading.


In the 19th century, the Romanian provinces overcame difficulties at all levels: political, social, cultural. Significant changes were also felt in the processes of reception and assimilation of European values when new aesthetics were integrated into indigenous mentalities according to the artistic, moral end ideological needs of Romanians. As formative minds, the writers wanted at all costs to adapt to the European context; they renounced pattern of ancient writing (neoclassical poetry, for example) and embraced new forms of literary expression. Moreover, by their education made according to the modern European spirit, they gave examples of erudition and education which were grafted on the national culture. Our study offers an incursion into the Romanian cultural space of the 19th century in order to present a faithful image of the cultural "renaissance" in the Romanian provinces of that time.


The paper briefly introduces the current situation of digital library services,clarifies the concept,model,form and content, category,consciousness of reader services transformation of hospital libraries under digital era,and proposes the librarian should meet the needs of new situation,for the sustainable development of the hospital.


The systemic insecticide imidacloprid has been used successfully to manage Bemisia argentifolii Bellows & Perring and whitefly-borne geminivirus on tomato in south Florida and elsewhere. We evaluated plant and whitefly responses to imidacloprid in greenhouse grown tomato, Lycopersicon esculentum Miller, transplants and field-grown fresh market staked tomato. Seedlings in transplant trays treated with 1 or 2 mg (AI) per plant applied as a drench were protected from egg deposition for up to 6 wk of exposure to a greenhouse colony of whiteflies. In the field, either 280 or 560 g (AI) ha of imidacloprid applied to the soil at transplanting provided protection from all whitefly stages and was better than or equal to protection obtained with weekly sprays of organophosphate/ pyrethroid insecticide mixtures for up to 9 wk. Movement of geminivirus infection vectored by whitefly adults was suppressed in small plots, indicating that imidacloprid acted rapidly on adults. Treated tomato or eggplant, Solanum melongena L. 'Black Beauty', functioned as trap crops by reducing whitefly numbers on adjacent untreated tomato. High application rates and persistence of imidacloprid have combined to increase the likelihood of insecticide resistance and to necessitate the development of an easily reproducible bioassay to facilitate monitoring. A leaf-dip bioassay indicated that the LC50 for 10-d-old whitefly nymphs to imidacloprid was 6.1 mg (AI) /liter and the LC90 32.6 mg (AI) /liter. These results could serve as a baseline for whitefly susceptibility in south Florida, given the lack of any previous exposure to imidacloprid of the tested population.


The design of a cement slurry for an oil well exposed to high temperatures have proved to be a challenge. Various additives are in use to prevent cement strength retrogression, and to maintain the needed rheological properties to work with the slurry. In the present study the rheological properties of selected high temperature slurries using different types of additives are measured. The effect of these additives onto the zeta-potential are also evaluated and collated with rheological data. INTRODUCTION During the drilling of oil wells in areas where the later oil production temperature can exceed 120C it is necessary to add silica to well cements to prevent strength retrogression. Addition of silica has yielded a change in time for the cement to cure in practical operations. A waiting time for cement to cure is extremely costly in oil well drilling and must therefore be minimised. The current study outlines some of the initial tests performed to understand the rheological behaviour and early hydration of cements, which have been used in practical applications where the anticipated curing history was not observed. The stability of some of the sulphate minerals used to control thickening and early stages of cure in cements changes at 42C1. Therefore, in the experiments all test were conducted at 25C, 34C and 49C, to illustrate practical temperatures for cementing a 13 3/8" casing in a 17 1⁄2" hole. EXPERIMENTAL CONDITIONS Sample preparation All samples were mixed in accordance with API2. However, the prescribed conditioning time, prior to any measurements, of 20 minutes was increased to 30 minutes for all our samples. Two series of tests were conducted. One using a Class G cement (Norcem A/S, Brevik) and water as a basis, in the other the cement was partly replaced by silica (quarts) flour. Silica flour is used to prevent compressive strength retrogression at high temperatures. Silica flour has a rather low surface activity. A negative Smoluchowski zeta potential of -9.89mV was measured on a 19% by volume suspension of pure silica flour in water. The average particle size is expected to be slightly higher than that of the cement which when measured gave a d50 of 8.44μm. The additives used came all as water based suspensions. A gas migration preventive, micro silica, or silica fume, was used. Micro silica is highly reactive. The particle size of the micro silica is small. A measurement on a sample containing 3.28% by volume gave a rather narrow particle size distribution with a d-50 of 0.45μm. The zeta potential measured on the same sample was -156mV, which is rather high. It is expected to be due to chemicals added to the micro silica to create a stable suspension Table 1. Sample composition.


Title Prevalence of Malnutrition and Associated Factors among Young Children in the Eastern Region of the Republic of Cameroon [an abstract of dissertation and a summary of dissertation review] Author(s) 長堀, 智香子 Citation 北海道大学. 博士(保健科学) 甲第12294号 Issue Date 2016-03-24 Doc URL http://hdl.handle.net/2115/61776 Rights(URL) http://creativecommons.org/licenses/by-nc-sa/2.1/jp/ Type theses (doctoral abstract and summary of review) Additional Information There are other files related to this item in HUSCAP. Check the above URL. File Information Chikako_Nagahori_abstract.pdf (論文内容の要旨)


A 61-year-old woman arrived at the emergency department of the Hospital Nossa Senhora das Gracas, Canoas, southern Brazil, with  suspected ischemic stroke . After clinical and laboratory examination, the clinical diagnosis of ischemic stroke was made, without fulfilling criteria for thrombolysis. The patient had no history of renal failure. Three days later, she performed a magnetic resonance imaging (MRI) examination that confirmed the  suspected  diagnosis. This examination was performed without sedation or supplemental oxygen. Brain MRI was performed after gadolinium injection, using fluid-attenuated inversion recovery (FLAIR) imaging, T1-weighted image, diffusion-weighted imaging, and T2-weighted image sequences that revealed signs of subacute watershed stroke in the left cerebral hemisphere (Figures 1, 2 and 3). There was a hyperintense cerebrospinal fluid (CSF) in the subarachnoid space (SAS) on FLAIR imaging, a finding that has been reported in many  pathologic conditions1 such as superior sagittal thrombosis, subarachnoid hemorrhage², meningitis,  meningeal carcinomatosis,  next to tumors, status epilepticus and stroke. 3-7 It has also been reported in otherwise healthy patients undergoing anesthesia with supplemental oxygen. 8 The exact mechanism by which CSF diffuses into the SAS in patients with or without renal insufficiency is not completely explained. Some authores have suggested that in patients with renal failure, the gadolinium may shift across an osmotic gradient at the circumventricular organs in the setting of proctracted elevation of plasma concentrations. 9 We believe that the cause of this imaging phenomenon of hyperintense signal of the CSF in the SAS which has already been noted in patients with compromised cerebral perfusion, including cases of acute ischemic stroke, was due to the recent stroke. 10-11 Keywords: Flair hyperintensity, MRI, stroke, Gadolinium


The amount of blood (as estimated by the amount of hemoglobin converted to pyridine hemochromogen) present in the lone star tick, Amblyomma americanum (L.), during each of its developmental stages after feeding on laboratory hosts was measured. Larvae allowed to feed to repletion contained about one microliter after spending close to 4 days on the host. Replete nymphs spent about the same amount of time on the host and imbibed about 19 microliters. Adult females ingested an average of 0.74 milliliters of blood but the time spent prior to repletion was variable (range: 7-15 days; average: 9.8 days). All stages concentrated the ingested meal, presumably by eliminating excess ions and water.


The world assortment of strawberries includes about 15 thousand varieties, lines and shapes. Breeding work continues in various directions, but the priority remains the creation of varieties characterised by high productivity, large-fruited and marketable fruits that meet the requirements of industrial cultivation. It is possible to increase the efficiency of breeding in this direction by finding and using new sources and donors of valuable traits. The aim of the research was to study the characters of productivity and quality of strawberry fruit in order to identify new breeding sources. The research was carried out at the strawberry genetic collection located in the Moscow region, at the Department of Genetics and Breeding of Garden Crops of the Federal Horticultural Centre for Breeding, Agrotechnology and Nursery. The subjects of the study were strawberry plants of 33 varieties of different genetic and geographical origin recommended in the scientific literature for industrial cultivation. The variety samples were studied according to the Program and methodology of variety studies of fruit, berry and nut crops. Microsoft Excel was used for statistical data processing by single-factor analysis of variance and grouping of varieties based on NSR0.5. When studying strawberry varieties grown under field conditions using traditional technology, the highest productivity was noted in the varieties: 'Rozana Kievskaya' (431.5 g/bush), 'Troitskaya' (392.7 g/bush), 'Al'fa' (322.4 g/bush), 'Irma' (318.2 g/bush), 'Kokinskaya Pozdnyaya' (300.2 g/bush). The sources of large fruit are identified in the varieties: 'Kokinskaya Pozdnyaya', 'Festival'naya Romashka', 'Irma', 'Arosa', 'Troitskaya', 'Florence', 'Jemma', 'Vima Kimberly', 'Tsaritsa', 'Nelly', 'Vityaz'', 'Asia', 'Selekta', 'Сlery', 'Vima Zanta', 'Urozhaynaya TsGL', 'Rozana Kievskaya', 'Al'fa', 'Alba', 'Venta', 'Tsarskosel'skaya', 'Bryanich', 'Borovitskaya', 'Tago'. The highest hardness of fruits was observed in the varieties 'Arosa' and 'Vima Kimberly' varieties. The varieties 'Kubata', 'Nelly', 'Florence', 'Asia', 'Alba', 'Irma', 'Tago', and 'Lakomaya' showed a high level of the trait. As a result of the study, sources of high potential productivity ("large fruit" and "number of ovaries per bush") were identified: 'Rozana Kievskaya', 'Troitskaya', 'Al'fa'. The varieties 'Florence', 'Vima Kimberly', 'Asia', 'Arosa', 'Irma', 'Nelly' are recommended as sources for fruit quality ("large fruit" and "fruit hardness").


A comparison of four computer codes for the analysis of two-dimensional single element airfoil sections is presented for three classes of section geometries. Two of the computer codes utilize vortex singularities methods to obtain the potential flow solution. The other two codes solve the full inviscid potential flow equation using finite differencing techniques, allowing results to be obtained for transonic flow about an airfoil including weak shocks. Each program incorporates boundary layer routines for computing the boundary layer displacement thickness and boundary layer effects on aerodynamic coefficients. Computational results are given for a symmetrical section represented by an NACA 0012 profile, a conventional section illustrated by an NACA 65A413 profile, and a supercritical type section for general aviation applications typified by a NASA LS(1)-0413 section. The four codes are compared and contrasted in the areas of method of approach, range of applicability, agreement among each other and with experiment, individual advantages and disadvantages, computer run times and memory requirements, and operational idiosyncrasies.


Objectives : The purpose of this study is to investigate satisfaction in major and job esteem of college students in dental hygiene and nursing department according to volunteering. Methods : This study was used on a descriptive research design. participants of this study were 378 college students in some region from April 30th to May 21th. The collected data were analyzed by SPSS Program(version 20.0) using descriptive statistics. Results : Volunteering experience subjects was 24.3%, the subjects did not experience volunteering was 75.7% and volunteering related to major was 59.8% and it was 40.2% of unrelated volunteering. Volunteering experience by general characteristics was influenced significantly by grade(p


The development of human civilization ignites a demand for various natural resources. Nowadays, these resources include not only useful minerals, soil, water, air, flora, or fauna, but also natural forces and other environmental assets determining the quality of human life, such as geographic space, landscapes, and microclimates. Among so many categories of natural resources, minerals - which are for the most part non-renewable - often constitute a deciding influence on the level of human well-being. Within the study of the utilization of natural resources, a series of models have been developed which are aimed - mostly in a dynamic mode - at maximizing the level of social well-being determined by the consumption of specific resources.


This is not a textbook of how one recognizes and treats a variety of psychiatric illnesses in general practice, as is suggested by the title. Rather, it is a republication of an important research study on psychiatric illness in general practice done by the General Practice Research Unit of the Institute of Psychiatry at the University of London. The study was originally published in 1966, and it is here reissued in its entirety. It is supplemented by a summary of the work in the area done between 1966 and 1980. The original study was important but, as pointed out by the authors, did not receive the attention warranted until general interest in the interface between general practice and psychiatry began to emerge in the late 1970s. This interface has played a major role in the family practice movement in this country, and as it is emerging around the world. If


• Proof: X is j G implies that V = uX is G with mean uμ and variance uΣu. Thus its characteristic function, CV (t) = e ituμe−t 2uTΣu/2. But CV (t) = E[e itV ] = E[e TX ]. If we set t = 1, then this is E[e TX ] which is equal to CX(u). Thus, CX(u) = CV (1) = e iuμe−u TΣu/2. • Proof (other side): we are given that the charac function ofX, CX(u) = E[eiuTX ] = e μe−u TΣu/2. Consider V = uX. Thus, CV (t) = E[e itV ] = CX(tu) = e iuμe−t 2uTΣu/2. Also, E[V ] = uμ, var(V ) = uΣu. Thus V is G.


AVIRIS has been widely used for airborne hyperspectral applications but also for inter-calibration experim with other multispectral and hyperspectral sensors. Special techniques are required for intercalibration an tral resampling between similarly performing hyperspectral sensors. Some experiments regarding the tec of spectral simulation for an upcoming hyperspectral instrument are shown herein. The simulation of a future hyperspectral sensor is essential to obtain an estimate about its perform and to test related algorithms for the expected new data. AVIRIS and other available hyperspectral data s used for the simulation of the Airborne PRISM Experiment (APEX) which is initiated by the ESA and will b built in a joint Swiss-Belgian project [Itten et al., 1997]. APEX is an airborne pushbroom imaging spectrom featuring approximately 300 channels in the wavelength range between 400 and 2500 nm. One of the ma nological achievements is the increased spectral resolution of 5 nm for APEX compared to 10 nm of AVIR between 400 and 1100 nm wavelength. Another goal is the use of 'pushbroom' technology at a high numb to 1000 pixels per line in order to simulate spaceborne instruments. Three major approaches are suggested to simulate APEX data: • A ray tracer model simulates the optical path from the ground through the instrument optics to the s to characterize the influence of the single instrument parts on the data quality. • The realistic radiometric and geometric performance analysis is based on currently available hypers instruments such as AVIRIS. • A third approach is the demonstration of the technology using a hyperspectral pushbroom instrume Only the second approach is described in this paper. The goal is the construction of data cubes of the sam tral and spatial resolution as the final APEX data products, but with the radiometric performance and the i geometry of current AVIRIS data. The pushbroom instrument simulation had to be dropped due to the lack appropriately performing sensor. The spatial resampling has been widely studied in the past and can therefore be treated with stand algorithms. Bilinear interpolation can be used for raw data resampling [Kellenberger, 1996; Schowengerdt while geocoding procedures can be used for the resampling to a fixed spatial resolution in a georeferenced [Schläpfer et al, 1998]. Thus, this paper concentrates on problems related to spectral resampling.


The main purpose of this conference paper is to highlight the problem of defining corruption, to identify the perspective of a theoretical analysis of corruption, the ways of its manifestation in school and the practical ways of controlling and preventing it. The abundance of personal information and experience makes the beneficiaries of education (students and parents) agree that corruption is a major "obstacle", not only in schools but also in other areas. Chapter 1 deals with the role of internal managerial control in improving quality and preventing corruption phenomena in schools. Chapter 2 deals with methodological issues and analyses, concrete examples of practices and abuses in various educational institutions, as well as the practical ways / tools that the school principal can use to create an organizational culture.


: Emergencies and their associated negative emotions have a great effect on public health. As a key part of emergency management, government information release (GIR) not only meets the public's health information seeking but also helps to eliminate the breeding and spreading of negative social emotions. From the two aspects of content features and lingual forms, a regression model was built to explore the mechanism of GIR on the regulation of public negative emotions by adopting the theoretical methods of content analysis and emotion calculation. During the emergency outbreak, if the government can timely release information on the incident and respond to the public using rational language, public negative emotions can be alleviated. During the emergency peak, the government should release the event progress, resolution, and disposal information to improve the recognition of public and eliminate negative emotions. According to different stages of emergencies, the government should timely and reasonably utilize the attitude tendency, content type, and lingual form of GIR to effectively regulate the public negative emotions.


Despite its great technological importance, the magnetoelectric (ME) couplings in \BF are barely understood. By using a first-principles approach, we uncover the {\it dynamic} ME couplings of the long-range spin-cycloid in BiFeO$_3$. Based on a microscopic Hamiltonian, our first-principles approach disentangles the hidden ME couplings due to spin-current and exchange-striction. Beyond the spin-current polarization governed by the inverse Dzyaloshinskii-Moriya interaction \cite{iDM}, various spin-current polarizations derived from both ferroelectric and antiferrodistortive distortions cooperatively produce the strong non-reciprocal directional dichroism or the asymmetry in the absorption of counter-propagating light in BiFeO$_3$. Our systematic approach can be generally applied to any multiferroic material, laying the foundation for revealing hidden ME couplings on an atomic scale and for exploiting optical ME effects in the next generation of technological devices such as optical diodes.


Things aren't shaping up as Nestle hoped. The company's recent appeal to have the four-bar shape of Kit-Kats trademarked as unique has fallen flat in the face of competition and you may be left wondering: what's the point?


This article proposes a conception of the teacher as an Impresario with a Scenario, a multi-centric and co-constructivist model in contrast to the familiarly student-centered and constructivist ideal of the Guide on the Side. I argue that the Impresario conception is truer to the practices of many teachers inspired by the "Guide on the Side" model, while at the Same time, explicitly recognized and embraced, it opens up many appealing and venturesome farther possibilities.


Wind-and-react coils using alumino-silicate-braid-insulated Bi2Sr2CaCu2O8+x (Bi-2212) round wire consistently show reduced critical current densities (Jc) compared to short samples heat treated under nominally identical conditions. This is a significant detriment to the design of Bi-2212 insert coils for high field magnets. Here we report on the superconducting properties of a series of wind-and-react test coils and short conductor samples systematically extracted from various sections of some of these wind-and-react coils. Overall we find remarkable uniformity of the superconducting properties throughout a majority of each coil, even though the Jc of the coil is markedly below that of short samples processed at the same time. Analysis of the critical temperature (Tc) and the irreversibility field (Hirr) shows that these Jc variations are solely related to changes in connectivity within the Bi-2212 filaments, rather than to any variations of oxygen uptake within the coil winding during heat treatment. We conclude that the reduced Jc of the coils is related to a sample length dependence of Jc rather than to any lack of full oxygenation of even a 20-layer coil. Raising the Jc of the coils thus appears to be a problem that needs addressing chiefly at the strand rather than the coil level.


Single dosis varying from 10 to 25g/kg of fresh green leaves of Phytolacca decandra were orally force fed to 11 sheep. Two of these sheep (20 and 25g/kg) died 6 hours after the ingestion of the plant and the other 9 got mildly sick and recovered. Another sheep was fed 4 daily dosis of 5g/kg of the same plant. This sheep and another two used as controls did not get sick. The main clinical signs in the affected sheep were abdominal pain, restless, pawing, respiratory distress, muscle tremors, and hyperesthesia. Gross findings in the two necropsied sheep were confined to the digestive tract and consisted of diffuse mucosal reddening of the rumen, reticulum, abomasum, and small intestine. Microscopic changes were coagulative necrosis and microabscesses in the mucosa of the forestomachs and several intratubular birefringent crystals in the kidney.


The towing process is the precondition to put a cylindrical drilling platform into use, which is saturated with risk due to the complexity of the towing environment, towing maneuvering, and the sudden and severity of accidents. Therefore, to control the cylindrical drilling platform towing system safely following a predefined course to reach the target see area becomes increasingly important. For environmental disturbances caused by wind and currents changing with time, a linear adaptive-disturbance-rejection-control (LADRC) based path following control method for cylindrical drilling platform towing system is proposed. Firstly, on the basis of both the mathematical modeling group model and the catenary model, three degrees of freedom nonlinear model of the cylindrical drilling platform towing system is built to obtain its real-time motion state. Then, a LADRC controller based on a two-dimensional trajectory tracking guidance law is designed for real-time path following control. Finally, simulation experiments of the path following control for the cylindrical drilling platform towing system is conducted. The results illustrate that the LADRC can effectively resist influences of the environmental disturbances and has a better path following performances than the traditional proportional–integral–derivative (PID) controller.


Background: Factor IX (FIX) has distinct pharmacokinetic properties compared to factor VIII including significant distribution to the extravascular space. Extravascular distribution and binding to type IV collagen is important in hemostasis but not readily measureable in clinical practice for patients with hemophilia B receiving factor products. We previously reported data regarding use of EHL-FIX products in a cohort of patients who demonstrated issues with spontaneous bleeding and poorly controlled bleeding events; we now report data from an expanded cohort including performance of all EHL-FIX products available in US and Canada.
 Aims: To characterize the use and performance of EHL-FIX in clinical practice at six hemophilia treatment centers (HTCs).
 Methods: An electronic survey regarding center specific use of EHL-FIX amongst patients with severe hemophilia B (HB) was sent in summer 2019, including 4 previously surveyed centers and 2 additional centers. Providers were asked if patients utilizing EHL-FIX for prophylaxis had experienced 1) spontaneous/minimally traumatic bleeding events at factor levels >10% or 2) poorly controlled bleeding events requiring more frequent/higher doses of EHL-FIX than anticipated in addition to patterns of EHL-FIX product switching.
 Results: Surveyed HTCs cared for 90 patients with HB including 67 (74%) who utilized EHL-FIX, including 26 (39%) recombinant factor IX (FIX) albumin fusion protein (rFIX-FP), 37 (55%) recombinant factor IX Fc fusion protein (rFIXFc), and 4 (6%) received glycopegylated recombinant FIX (rFIX-GP). All patients had severe hemophilia B with the exception of one smaller center also contributing data regarding moderate HB patients on prophylaxis. All centers reported having patients with unexpected spontaneous/minimally traumatic bleeding and poorly controlled bleeding which did not seem to be dependent on age (median age 14.5 years, range 1.4-44). This occurred in 18 patients on prophylaxis, including 16 of 26 (62%) patients using rFIX-FP, and 2 of 4 (50%) of patients using rFIX-GP.
 Conclusions: Although plasma FIX activity levels have driven prophylaxis and bleed management decisions, clinical experience suggests novel properties of EHL-FIX may impact hemostasis. Although achieving seemingly adequate FIX plasma troughs (>10%), limited clinical experience suggests patients with SHB may have a differential response to EHL-FIX, noted in our cohort with FIX-FP and rFIX-GP.
 Successful bleed prevention or control in SHB may be predicted by the distribution of FIX in circulation and extravascular space, and the presence of FIX in tissues at time of injury. These data demonstrate the importance of real-world monitoring of efficacy of new FIX products and suggest the need for more robust mechanisms to understand the hemostatic performance of products.

 Malec: Bayer: Honoraria; Spark: Honoraria; CSL: Honoraria; Sanofi: Consultancy, Honoraria, Speakers Bureau; Takeda: Honoraria. Croteau:Novo Nordisk: Consultancy, Honoraria, Research Funding; Shire: Consultancy, Honoraria; Bayer: Consultancy, Honoraria; Bayer: Consultancy, Honoraria; Octapharma: Honoraria; Octapharma: Honoraria; Genentech: Consultancy, Honoraria; Pfizer: Research Funding; Spark Therapeutics: Research Funding; Novo Nordisk: Consultancy, Honoraria, Research Funding; Spark Therapeutics: Research Funding; Pfizer: Research Funding; Genentech: Consultancy, Honoraria; CSL Behring: Consultancy, Honoraria; CSL Behring: Consultancy, Honoraria; Shire: Consultancy, Honoraria. Callaghan:Biomarin, Bioverativ, Grifols, Kedrion, Pfizer, Roche/Genentech, Shire, and Spark Therapeutics: Consultancy; Alnylum: Equity Ownership; Bayer: Consultancy, Speakers Bureau; Takeda: Consultancy, Research Funding; Sanofi: Consultancy; Global Blood Therapeutics: Consultancy; Novonordisk: Consultancy, Speakers Bureau; Octapharma: Consultancy; Pfizer: Research Funding; Roche: Research Funding; Shire/Takeda: Speakers Bureau; Roche/Genentech: Speakers Bureau. Matino:Bayer: Honoraria, Research Funding; Sobi: Honoraria, Research Funding; Pfizer: Honoraria, Research Funding; Roche: Research Funding; Bioviiix: Honoraria; Sanofi: Honoraria. Friedman:CSL: Consultancy; Bayer: Consultancy; Genentech: Consultancy; Instrumentation Laboratory: Consultancy; Siemens: Consultancy. Sidonio:Grifols: Membership on an entity's Board of Directors or advisory committees, Research Funding; Genetech: Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda-Shire: Membership on an entity's Board of Directors or advisory committees, Research Funding; Bioverativ: Membership on an entity's Board of Directors or advisory committees, Research Funding; Octapharma: Membership on an entity's Board of Directors or advisory committees, Research Funding; Uniqure: Membership on an entity's Board of Directors or advisory committees; Novo Nordisk: Membership on an entity's Board of Directors or advisory committees; Biomarin: Membership on an entity's Board of Directors or advisory committees; Kedrion: Research Funding.


Abstract : Experiments with a three-component laser anemometer on the wake and vortex structure behind a model wing at incidence in a 4ft x 3ft subsonic test section are described. Three colours from the output spectrum of an argon-ion laser were used for the three Doppler-difference arrangements. The complete optical system operated in backscatter and was mounted on a single table which could be translated in three orthogonal directions. An integrated data acquisition and reduction system was used incorporating a photon correlator and a Honeywell 6/36 minicomputer. The output data consisted of mean-velocity and turbulence-intensity values for all three components at each measurement point. From these data, the mean-velocity components in the directions of the conventional tunnel axes could be derived by means of a linear transformation. However, the measured turbulence intensities do not yield the turbulence intensities for these components without additional assumptions or supplementary information. (Author)


ABSTRACT A novel algorithm imitating the defending process of immune system to resolve the overlapping nuclear magnetic resonance (NMR) spectra is proposed. The method takes an overlapping NMR spectrum as an antigen, and the standard NMR spectra of estimated components as antibodies. The antigen is subtracted iteratively by the antibodies until the residual approaches to zero, and then the information of each component will be extracted. Simulated data sets and a spectrum of a ten-component mixture of amino-acids were investigated by the method. It was proven by the results that the method is a convenient tool for the resolution of multicomponent overlapping NMR signals, and is a promising way to analyze the NMR spectra of mixtures or complex bio-molecules.


Imaging log is used widely for its higher discernibility,but the firsthand image usually reflect formation feature indistinctly.Static state normalization image is applicable to display logging response with large variable range and lithology analysis result.Dynamic intensify image increases its definition in borehole zone,but makes the image step-shaped because of the use of narrow window.Both of smoothing filtering or re-sampling cannot remove the step.Based on histogram local equalization method,this paper utilizes Morphing technique to do linear interpolation to the color data to smooth the step.The result shows that the step problem can be effectively resolved in this way.


Using a simple criterion proposed by Kirzhnitz,we have discussed the plasma-solid transition in two simple model cases: the Fermi-Dirac and Bose Einstein gas.Some possibilities of astrophysical applications of our results are also indicated.


In allustion to current worsening global financial crisis,rapid descendence of global economy,the severe situation that financial crisis has gradually turned into economic crisis,this article analyzes domestic economic situation and different policies and measures taken to encounter global financial crisis.Based on actual condition of copper manufacturing industry and the company itself,the author puts forward his own views and measures on how to exploit sales market and control business risks so as to ensure stable growth of the company.


We have performed systematic measurements of the splitting kinetics induced by H-only and He+H sequential ion implantation into relaxed Si0.8Ge0.2 layers and compared them with the data obtained in Si. For H-only implants, Si splits faster than Si0.8Ge0.2. Sequential ion implantation leads to faster splitting kinetics than H-only in both materials and is faster in Si0.8Ge0.2 than in Si. We have performed secondary ion mass spectrometry, Rutherford backscattering spectroscopy in channeling mode, and transmission electron microscopy analyses to elucidate the physical mechanisms involved in these splitting phenomena. The data are discussed in the framework of a simple phenomenological model in which vacancies play an important role.