Today,global drug smuggling has formed a self-contained networks of smuggle routes,products,supply and sales,and come being a global business without borders.Suggested countermeasures are: 1,Insist on reducing supply from drug origin areas and reduce drug distribution,and combine the assistance and punishment together;2,Economic cooperation with South-east Asia countries;3,Reinforce inspection on cross-national drug crimes;4.Reinforce regional anti-drug law enforcement collaboration;5,Improve technical elements in drug inspection;6,Perfect drug legislation;7,Increase international drug control cooperation.


The subject innovation is roller capable of performing, in the affected part through the rolling contact of the roller cooled by a cryogenic liquefied gas is simple and inexpensive freezing treatment and management relates to a roller-type skin care device that is used for freezing the treatment and control of skin It aims to provide a skin care type. The invented to achieve the above object, in contact with the affected part in the cooled state by the roller of the cryogenic liquefied gas for cooling the affected part through the rolling motion; A support member coupled to the center of rotation of the roller support rotatably a roller to the axis; And it provides a roller-type skin care device for refrigerating treatment and care comprising a handle coupled to an opposite side portion of the roller is joined to the support member. Cryotherapy, skin care, liquefied gas, liquid nitrogen, roller


ous experiments be rendered demonstrably incapable of surviving outside the laboratory environment. Again at the risk of simplification, the Woods Hole guidelines stipulate the following three levels: EKI: Just use the standard laboratory version of E. coli K 12 as the host for your recombinant DNA molecule, and use E. coli's standard virus or plasmids (independently replicating bacterial chromosomes) as the vector (that is, as the means of getting your molecule inside the bug). EK2: Use strains of E. coli genetically altered so as to be in theory 106 times less likely to escape successfully from the lab than standard E. coli K 12. EK3: Same as EK2, except that someone has gotten around to actually confirming by empirical test that the disarmed


Since the link structure of the web is an important element in ranking systems on search engines, web spammers widely use the link structure of the web to increase the rank of their pages. Various link-based features of web pages have been introduced and have proven effective at identifying link spam. One particularly successful family of features (as described in the SpamRank algorithm), is based on examining the sets of pages that contribute most to the PageRank of a given vertex, called supporting sets. In a recent paper, the current authors described an algorithm for efficiently computing, for a single specified vertex, an approximation of its supporting sets. In this paper, we describe several link-based spam-detection features, both supervised and unsupervised, that can be derived from these approximate supporting sets. In particular, we examine the size of a node's supporting sets and the approximate l2 norm of the PageRank contributions from other nodes. As a supervised feature, we examine the composition of a node's supporting sets. We perform experiments on two labeled real data sets to demonstrate the effectiveness of these features for spam detection, and demonstrate that these features can be computed efficiently. Furthermore, we design a variation of PageRank (called Robust PageRank) that incorporates some of these features into its ranking, argue that this variation is more robust against link spam engineering, and give an algorithm for approximating Robust PageRank.


We compared the gap-producing forces, ultimate tensile strength, and slip resistance of a new core suture technique and that of a modified Kessler suture in freshly harvested chicken tendons. Biomechanical trials were carried out using a tensile-strength testing machine. Our technique proved superior to the modified Kessler suture with respect to its ultimate tensile strength and slip resistance.


[Objective]The effect of the NaCl stresses on maize seed germination and seedling growth was studied.[Method]Maize varietyNongda No.108 being taken as the experimental material,the eight concentrations of NaCl affecting maize seed germination and seedling growth was experimented.[Results]The germination rate,the height and weight of seedling,the number,length and weight of root of maize were significant downward trend as the NaCl concentration increasing.The reaction of the height of plant and the length of root of maize seedling were most sensitive to the NaCl stress and the tolerance of maize seedling in number and weight of root to NaCl stress was strong.[Conclusion]The reaction of the different positions of maize to NaCl stress varied.


This paper provides an initial meta-framework for the drives toward memory affinity for C++. It accounts for feedback from the Toronto 2017 SG1 meeting on Data Movement in C++ [1] that we should define affinity for C++ first, before considering inaccessible memory as a solution to the separate memory problem towards supporting heterogeneous and distributed computing.


High-temperature joining is a key technology for electronic component assembly and other high-temperature applications. Recently, focusing on the sintering behavior of metal particles, the joining process using a nanoparticle paste has been proposed as an alternative to establish a new joining technology for high-temperature applications. In this study, a feasibility study was conducted to determine whether chestnut-burr-like microscale Ag particles can be used for joint material, and the shear strength of the Cu-to-Cu joints was investigated. Then, the interfacial microstructure of the joints using the microscale particle paste was examined. As a result, joining using microscale Ag particles was successfully achieved and the shear strength of more than 20 MPa was obtained under nitrogen atmosphere.


Double strand breaks (DSBs) are one of the most cytotoxic DNA lesions known and therefore pose a constant threat to genomic integrity. If left unrepaired, DSBs can lead to mutations and chromosomal aberrations which are often associated with cancer. Eukaryotic cells employ a sophisticated DNA damage response (DDR) to protect their genome from DNA damage, such as DSBs. During the DDR to DSBs, one of the most distinctive hallmarks of the response is the ordered assembly of damage signaling and repair proteins into multi-protein complexes in the vicinity of the DSB. The accumulated proteins form so-called ionizing radiationinduced foci (IRIF), which are detectable by immunofluorescence microscopy. Over the last decade, the list of proteins residing in IRIF has been rapidly expanding, and now includes ATM, NBS1, phosphorylated H2AX, MDC1 (mediator of DNA-damage checkpoint 1), E3 ubiquitin (Ub) ligase RNF8, RNF168, MOF, ubiquitinated H2AX/A, BRCA1 and 53BP1 among others. It is widely recognized that the recruitment/accumulation of these DDR factors or factor complexes is initially triggered by ATM-dependent phosphorylation of H2AX, which is instrumental for the recruitment of MDC1. The MDC1 protein in turn recruits RNF8, which in concert with RNF168, initiates the crucial Ub-dependent signaling cascade. The ubiquitin ligase RNF168 was identified as a key factor in forming 53BP1 IRIF and RNF168 gene mutations were shown to be responsible for RIDDLE syndrome. This human genome instability syndrome manifests diverse clinical features, such as radiosensitivity, immunodeficiency, facial dysmorphism, and mild motor control and learning difficulties. Some of these features are also common to ataxiatelangiectasia patients. Studies have shown that RNF168 is an E3 Ub ligase that ubiquitinates histones H2A and H2AX at lysines (K) 13 and 15 (K13/15), which are distinct from the first H2A ubiquitination sites identified and found at K118/119. The poly K63-Ub chains at K13/15 on H2A/X are the result of subsequent RNF8-catalyzed Ub chain extension. Both BRCA1 and 53BP1 bind to polyubiquitinated H2A/X. BRCA1 is recruited in a RAP80-AbraxasBRCA1-BRCC36 complex in which RAP80 is capable of binding Ub moieties through the Ub-interacting motif (UIM) domain, while 53BP1 recognizes nucleosomes containing dimethylated H4K20 and ubiquitinated H2A through its Tudor domain and ubiquitinationdependent recruitment (UDR) motif, 5 respectively. While much remains to be unraveled about this Ub-dependent signaling pathway, we know that BRCA1 and 53BP1 determine the DSB repair pathway choice between homologous recombination (HR) and nonhomologous end joining (NHEJ). Although the RNF8 and RNF168-mediated Ub-dependent signaling cascade is critically important for the eukaryotic cell's ability to cope with the burden of DSBs, how the cell regulates RNF8 and RNF168 is largely unknown. Both TRIP12 and UBR5 were identified as negative regulators of RNF168, however, whether RNF168 is a direct substrate of these E3 ligases is unknown. Against this backdrop, in their newest studies, Zhu et al. show that the USP7 deubiquitinase enzyme promotes Ub-dependent DNA damage signaling by stabilizing RNF168. 7 They provide substantial evidence that USP7 deficiency curbs Ubdependent signaling during the DDR to both UVR and IR-induced DNA damage. Zhu and colleagues further demonstrate that USP7 interacts with and deubiquitinates RNF168. It had previously been documented that USP7 regulates Ring1B and Bmi1 Ub ligases, 2 components of Polycomb repressive complex 1 (PRC1), which are also DDR participants, generating monoubiquitinated H2A at K118/ 119 (uH2A). Zhu et al have combed through the tangled relationship of H2A monoubiquitination and H2A/X polyubiquitination with bypass experiments, which estimated the contribution of USP7-mediated RNF168 regulation to the Ub-dependent signaling cascade. A similar approach previously helped to define RNF8 and RNF168 as targets of HSV-1 encoded ICP0 E3 Ub ligase. In general, the study has revealed that USP7 is a new regulator of Ub-dependent signaling cascade. The study has also raised some interesting questions and possibilities. For example, BRCA1 and Chk1 are both down regulated in USP7-deficient cells. Are BRCA1 and Chk1 also substrates of USP7? With a growing number of USP7 targets and inhibitors now identified, the testing of USP7 as a plausible therapeutic target for cancer warrants close attention.


The Purpose of this study is to analyze the effects of approach accuracy whether he/she is conformed with distance information or not while pro-golfer perform approach shot. Subjects, to be selected for the experiment, is involved in KPGA and KLPGA each of 5, respectably. The equipment used in the measurement for getting the data is Trackman Pro, produced by Trackman, Co, Ltd., that it is used to measure the distance they performed. The conclusions are as follows: Firstly, there are significantly different intra group, male and female group whether he/she is provided the information or not about the degree of visual approach accuracy on 45m target.(p .05) Also there are significantly different between groups, male and female group about the degree of visual approach accuracy on 45m target.(p Secondly, there are significantly different intra group, male and female group whether he/she is provided the information or not about the degree of visual approach accuracy on 60m target.(p Thirdly, there are significantly different intra group, male and female group whether he/she is provided the information or not about the degree of visual approach accuracy on 90m target.(p<.05) Also there are not significantly different between groups, male and female group about the degree of visual approach accuracy on 90m target.(p<.05)


This paper explores an adaptive feedback linearization for an uncertain nonlinear system using support vector regression (SVR). SVR, which assures global solution by quadratic programming (QP) problem, is used to learn the nominal dynamics of the input-output feedback-linearized system. Then, an adaptation algorithm of the offline-trained SVR is proposed for eliminating the offline-training error and uncertainties in the control process. In addition, the derivation of the adaptive rule considers the controller singularity problem by utilizing the affine property of the nonlinear system and the concept of the virtual control. Uniformly ultimately bound property of the overall system is analyzed by the Lyapunov stability theory. Simulations using a longitudinal dynamics of the F-16 model validate the performance of the proposed approach.


Performing a software modification requires a developer to investigate a program to find and understand the code relevant to the modification task. Although standard program investigation tools can help developers in this activity, developers often get lost in the complex web of information available about a program. To address this problem we propose to use program navigation analysis, a technique to record and analyze the actions of a developer using a software development environment in order to infer the current task and the subset of a program relevant to this task. Our hypothesis is that we can use the results of program navigation analysis to dynamically configure the interface of a software development environment in a way that alleviates the problems of disorientation experienced by developers. In this paper, we define program navigation analysis and present an overview of its underpinnings, summarize our experience with the technique, highlight important techni cal challenges, and discuss the benefits that can be reaped from use of the technique.


Behavioral economics refers to the economic theory that takes human behavior as the basic research object. It conducts regular research on the economic behavior characteristics of individuals and groups through observation and experiment. It constructs theory based on reality, thus freeing the shackles of traditional theory based on Abstract assumptions and often based on actual assumptions, and injecting vitality and vitality into economic research. Behavioral economics advocates and pays attention to the study of human economic behavior, and constructs a theoretical framework of "humanity and human value" for modern economics, making economics a human science and human being the main body of economics.


There is usually a waste of energy consumption in building systems. To help
 buildings reduce energy waste, the article established a building-sharing
 heat and power energy sharing system to achieve optimal energy allocation.
 Furthermore, the report determined the dual operation strategy model of
 using heat energy to determine power supply and electricity to determine
 heat energy. At the same time, we use stochastic programming and
 multi-objective optimization of the heating model and propose a two-level
 optimization model solution method based on the Benders decomposition
 algorithm. At the end of the thesis, the process was applied to actual cases
 to verify the method?s effectiveness.


Abstract. Phase retrieval with unidirectional differential phase-contrast image requires integration with noisy data, which is an illposed inverse problem. Conventional direct integration method would result in severe streak artifacts. Total variation (TV) regularization-based method would reduce the streak artifacts, but the edges parallel with phase-contrast sensitivity direction are likely to be over smoothed. We propose an improved weighted TV regularization phase retrieval method by introducing a weighting factor to the conventional TV term. When applied to simulation and experimental data, this method shows an advantage of preserving the sharpness of the edges while preserving the ability of reducing streak artifacts compared with conventional TV-regularization method.


This paper reports the simulation approach and prediction of annual energy performance of PV ventilated glazing systems with daylight saving as applying to typical office environment. Our computer model was developed via the ESP-r simulation platform in association with the RADIANCE lighting software. The new attempt of using indirect interaction between the two simulation programs through daylight coefficient, together with the coupled air-flow network and energy balance technique, has been proved very useful in tackling this kind of long period analysis. The simulation results show that for the range of climate regions from tropical to temperate, the PV natural-ventilated glazing system has advantages over the absorptive natural-ventilated glazing option as well as the single-pane glazing systems.


Social media is becoming one of the dominant ways to communicate. Before social media, people were extremely limited in their means to interact with others, and they were limited largely to the people that they knew in person. However, this impact on people in real life has damaged privacy. Alternative solutions have been proposed in order to overcome current social media issues. In this direction, blockchain is one of the most promising, and several blockchain-based social media have been proposed. In this paper, we analyze blockchain online social media from the technical point of view in order to understand the current trend of social DApps and to describe which characteristics are important in a blockchain-based social media scenario. We analyze real data by exploiting one of the most well-known DApps sites, and we compare current technologies in order to highlight which ones can be better applied to a real social scenario, such as Facebook.


The aim of study was to analyse the activity of four biocides. Assessment was made using the methodology described by the Clinical and Laboratory Standards Institute (CLSI); Antifungal Susceptibility Testing of Yeasts, M27-A3 Approved Standard, in: Candida sake, C. albicans, C. lusitaniae and Rhodotorulla rubra. The outcome, related to the culture2 s cut-off value of optical density (O.D.) was analysed statistically (p = 0.05 or lower) proving that Candida albicans was capable of generating strong biofilms, in the resistance setting (p = 0.001).


Applications running on a large distributed system face a dynamically changing environment. Thus, an application needs to adapt to new conditions or it will fail to continuously meet its specification. This is especially crucial if the application needs to implement a certain quality of service (QoS). Object-based middleware systems like CORBA implementations are currently not able to directly support QoS-aware applications. AspectIX is a novel and CORBAcompliant middleware architecture, in which so-called aspects define and describe QoS requirements on a per object basis independently from the functional interface. The aspect configuration can dynamically be changed by the client. Additionally, AspectIX allows object developers to implement QoS requirements in arbitrary ways. A partitioned object model, which is the basis of AspectIX, provides full control over the client side of an object invocation and thus allows end-to-end QoS.


1. Sudarshawn Damodharan, DO*
2. Istvan Danko, MD, PhD*
3. Hau D. Le, MD†

1. *Department of Pediatrics,

2. †Department of Surgery, American Family Children's Hospital–University of Wisconsin, Madison, WI

A 13-year-old premenarchal, obese girl with a past medical history significant for anxiety presented to the emergency department with multiple episodes of nonbloody, nonbilious emesis. She also reported having worsening nausea over the past week along with constant and diffuse abdominal discomfort for the past few months. Her parents had given over-the-counter omeprazole and antacids with no relief. Review of systems was negative for weight loss, diarrhea, hematochezia, fatigue, or decreased appetite.

Vitals obtained were within normal limits. She was afebrile. On physical examination, the patient appeared anxious. A complete physical examination showed no evidence of abdominal distention, tenderness, hepatomegaly, or splenomegaly upon palpation.

Her blood work was significant for leukocytosis with white blood cell count of 12.9 × 103 /μ L, elevated inflammatory markers with a c-reactive protein of 5 mg/L, and erythrocyte sedimentation rate of 39 mm/hour. Her complete metabolic panel was unremarkable. A computed tomography scan of the abdomen showed a large amount of heterogeneous material within the stomach, a high-grade small bowel obstruction (SBO), and fecal material in the terminal ileum (TI) along with wall narrowing and thickening of the TI without a focal lesion.

The patient was admitted to pediatric general surgery service for management of her SBO. Given the findings of bowel wall thickening of the TI and elevated inflammatory …


With the emergence of COVID-19 pandemic, new attention has been given to different acoustic bio-markers of the respiratory disorders. Deep Neural Network (DNN) has become very popular with the audio classification task due to its impressive performance for speech detection, audio event classification etc. This paper presents CoughNet-V2 - a scalable multimodal DNN framework to detect symptomatic COVID-19 cough. The framework was designed to be implemented on point-of-care edge devices to help the doctors at pre-screening stage for COVID-19 detection. A crowd-sourced multimodal data resource which contains subjects' cough audio along with other relevant medical information was used to design the CoughNet-V2 framework. CoughNet-V2 shows multimodal integration of cough audio along with medical records improves the classification performance than that of any unimodal frameworks. Proposed CoughNet-V2 achieved an area-under-curve (AUC) of 88.9% for the binary classification task of symptomatic COVID-19 cough detection. Finally, measurement of the deployment attributes of the CoughNet-V2 model onto processing components of an NVIDIA TX2 development board is presented as a proposition to bring the healthcare system to consumers' fingertips.Clinical relevance—CoughNet-V2 will help medical practitioners to asses whether the patients need intensive medical help without physically interacting with them.


"Emerging Coalitions: Challenging the Structures of Inequality" was the title of the eighth ClassCrits conference which took place on October 23-24, 2015, at the University of Tennessee College of Law. The Southwestern Law Review and the Tennessee Journal of Race, Gender, and Social Justice have graciously agreed to publish selected papers presented at the conference. In this foreword, we take a moment to critically reflect on the conference, its theme, and the papers published in these two symposium issues. ClassCrits is a collection of progressive scholars and activists committed to a critical analysis of law, economics, and inequality. Emerging out of two workshops held at SUNY Buffalo Law School in 2007, the ClassCrits name encompasses two interrelated goals. The "crits" suffix was selected to align the movement with other groups engaged in a critical analysis of the law, such as critical race theorists ("race-crits"), feminist theorists ("fem-crits"), LGBT theorists ("queercrits"), or "just plain 'crits.'" Second, the focus on "class" was meant to signal an interdisciplinary approach to the economic analysis of the law, one that would function as an alternative to traditional "law &


The present invention relates to a method for the preparation of multi-block copolymer, dispersion of multi-block copolymer, vesicles and micelles containing multiblock copolymer, and provides a product of the oxidation decomposition of the multiblock copolymer.


The following study deals with the detailed reviews regarding the interventions that have been done globally in the sector of entrepreneurial interventions in aspect of work simplification. Various standards hence can be considered while referring to different designs for enterprises, especially small scale enterprises. The studies have revealed the musculoskeletal disorders from manual material handling (MMH) works often involving strains and sprains to the lower back, shoulders, and upper limbs. The ergonomic interventions are found to give comfort to the workers in various postures. It is concluded that the design of the system must be incorporating to the worker, equipment, and environment as a whole.


Abstract Although blends of modifiers have been used in the manufacture of SBR elastomers and similar polymers in emulsion systems for a long time, no studies of the kinetics of their reaction nor of their effect on molecular weights have been reported. This is such a study. Model equations for blends of modifiers are derived to predict modifier depletion and polymer molecular weight. These equations are used to serve as guides for preparing blends of modifiers in SBR-type polymerizations and for comparisons with experimental results.


Nowadays there is not only an increase in the number of cartels in Russia but also their qualitative transformation in connection with the "digitalization" of public relations. In this regard, efforts of the FAS Russia to collect evidence on new types of cartels are becoming more complex. To solve the emerging difficulties, the FAS Russia drafted a law project aimed at expanding its full powers, including authorizing the antimonopoly authority to seize documents and items. In the article, the authors carry out a comparative analysis of the proposed innovations with the authority to seize from other state authorities and give a critical assessment of the current version of the draft law.


K-shell ionisation probabilities were measured for impact parameters between about 10 and 100 fm in collisions between Xe40+ and Sn, Sm, Au and Th. The present data are compared with measurements of ionisation probabilities and total 2p sigma cross sections for other collisions with united-atom atomic numbers up to Zu=184. Also, comparison is made with theories of direct ionisation from the 2p sigma molecular orbital and with a proposed theory involving the two-step transfer of projectile M vacancies into the 2p sigma molecular orbital. The bulk of the high-Z data are in better agreement with the direct ionisation theory.


Depressive syndromes are commonly seen in the primary care setting. Major depression affects 4.8% to 8.6% of the general US population in any given year; other types of depression affect an additional 3% to 8.4% of patients.1 Total costs of depression, including direct medical costs and indirect costs due to days lost from work, exceed $43 billion annually.1,2

In the primary care setting, treatment of depression usually includes evaluation by a physician, brief patient education, and either antidepressant therapy, referral to a behavioral health specialist, or both a prescription and a referral. Although most depressed patients can be successfully treated by primary care clinicians, depression remains unrecognized or undertreated in many patients.

In 2001, the Kaiser Permanente Care Management Institute (CMI) revised its guideline for evidence-based care of depressed adult outpatients in the primary care setting.3 This article and case example highlight key steps and recommendations from this guideline.


1,1,3,3-Tetramethylguanidinium hydrogen sulfate (TMG·HSO4) catalyzed conversion of xylose to furfural in water enriched with carbon dioxide at high temperature is described. The presence of carbon dioxide exhibited significant enhancement in the reaction rates and produced product yield more than 90%. The probable reasons for this rate enhancement are the following: (i) carbon dioxide might be reducing the viscosity of the reaction medium for better mass transfer and therefore enhancing the reaction; (ii) the reaction between carbon dioxide and water at higher temperature produces carbonic acid, which subsequently dissociates to increase the hydronium ion concentration and in turn the acidity of the medium.


An increasing number of primary care organisations are tackling rising healthcare costs and drug wastage through the use of a prescribing decision support tool called ScriptSwitch. Martyn Carroll, Head of Medicines Management at ScriptSwitch, examines the financial challenges that prescribers are currently facing in the NHS and provides an insight into a simple yet innovative solution.


An efficient and accurate numerical frequency domain formulation is proposed to investigate the 2D acoustic wave propagation within a shallow water region with a rigid bottom and a free surface. The proposed configuration combines different regions that have either a sloping or a flat rigid bottom. The numerical approach used here is based on the method of fundamental solutions (MFS). In this model only the vertical interface between different regions is discretized, as the model incorporates Green's functions that take into account the free water surface and the presence of either a horizontal or sloping rigid bottom.


An optical time domain reflectometer(OTDR) using appropriate encoding light pulses as probe signals can has much better performance than conventional OTDR , for example, improve the measure dynamic range but not reduce the resolution, reduce the required measurement time and so on. This paper present application study of one zero correlation window complementary coded sequence in OTDR, discussed the theoretical foundation of this method and introduced the method to change bipolar codes to unipolar codes, shown the Matlab simulation results at last.


The present invention allows a further increase in a treatment effect of a medical sheet material which is used in treatment of a living body, for example, muscle stiffness or pain, cuts, etc., of a human being. A medical sheet material working method according to the present invention uses: a power source device formed from an AC power source which is grounded at one output terminal, and an LC parallel circuit which is connected in series to the other non-ground side output terminal of the AC power source, said power source device outputting a superpositioned wave (vo) of an output voltage (v) of the AC power source and an induced electromotive force (v') which is induced in the LC parallel circuit by an external electromagnetic wave with the other terminal of the LC parallel circuit as an output terminal; and a conductive electrode plate connected via a lead wire to the output terminal of the power source device and comprising a far-infrared radiator layer. A medical sheet material is positioned upon the upper part of the far-infrared radiator layer of the conductive electrode plate, either directly or with a gap therebetween. A fluctuating electrical field is generated in the conductive electrode plate by outputting the superpositioned wave (vo) from the output terminal of the power source device to the conductive electrode plate, the medical sheet material overall is located within the fluctuating electrical field, and the medical sheet material overall is activated.


Lameness is a common disorder in US dairy herds and a welfare concern. Compared to non-lame cows, lame cows spend more time lying down. Although regular hoof trimming is often a component of lameness prevention efforts, increased lying time has been observed following hoof trimming, suggesting that it may cause discomfort in dairy cows. Preliminary work suggested that treatment with a non-steroidal anti-inflammatory drug decreases the duration of increased lying time after hoof trimming. The objective of this study was to examine interactions between lameness, hoof trimming, and non-steroidal drug therapy. Our hypothesis was that cows treated with flunixin meglumine before and after hoof trimming would spend less time lying, have improved gait scores, and produce more milk than cows that had their hooves trimmed without concurrent drug treatment.


The present work shows the research results of phase formation in obtaining high-alloy powder of Fe-Cr-Ni-Mn-N by mechanochemical synthesis in various gas atmospheres.


I have long been interested in integrating the development of theories regarding psychic trauma and interweaving them with classical conflict theory. For this reason, I have followed the S andor Ferenczi revival, which started about thirty-five years ago. The emotions regarding Ferenczi have frequently been extreme—positive or negative, either demonizing or worshiping him. On the negative side, Ferenczi's name has been used to justify esoteric, unorthodox practices in psychoanalysis and psychotherapy, laying him open to criticism. But he has also been highly admired by some for his original contributions to psychoanalysis and by others as an early rebel against Freud; further, publication of the Freud-Ferenczi correspondence unveiled the centrality of their friendship in the development of the field (more about this in what follows). The reader of Ferenczi's Influence on Contemporary Psychoanalytic Traditions can absorb the best Ferenczi scholarship over these last thirtyfive years, depicting this range of responses. Useful as a source book or a teaching tool, the book also points readers toward original sources cited by the authors of the individual chapters, serving as a valuable repository of primary data. The volume is organized in four parts, starting with a biographical/ historical section, followed by a section on Ferenczi's clinical contributions. The third section delves into his influence on major psychoanalytic thinkers who followed him, such as Melanie Klein, Harry Stack


The questions to assess the current state of dust and gas air pollution at the sites of open-pit mining, the example Mugunskogo lignite deposits.


I don't recall any reference to mutual interests with librarians in the various journalism publications I read and conferences I attended, not to mention the newsrooms where I worked -vice versa for library publications, conferences, and workrooms. Newspaper editors were traditionally wary about allying with anybody about anything for fear of losing their journalistic objectivity. Meanwhile, librarians saw the press as a conduit for promoting library programs and perhaps as a watchdog over library policies and spending – if the newspaper bothered to cover the library board meetings at all.


By using racemic (rac)-2-amino-1,2-diphenylethanol and achiral fluorescent 1-fluorenecarboxylic acid, a two-component columnar host system with multiple molecular response (guest-dependent spontaneous resolution and fluorescence) properties in the solid state was created.


Nonpolar block copolymers may be selectively multisite substituted in only one block with various functional groups, like carboxyl, hydroxy, or alkyl groups. In this way, block copolymers with unusual structures are easily accessible. The degree of substitution in the functionalized blocks may be controlled in a wide range and copolymers with various concentrations of substituents arise. The procedure of functionalization involves selective multisite metalation of the block copolymer by Superbase, made from 3-(lithiomethyl)heptane and potassium tert-pentoxide, and subsequent reaction of the metalated copolymer with an electrophile. Hydrophilic−hydrophobic block copolymers prepared by this method were investigated with regard to formation of micellar solutions in aqueous media.


In order to study the load-deflection characteristics of bridge prestressed concrete beams with unbonded tendons,a plane stress isoparametric element FEM model was established for a T-shaped prestressed concrete beam with straight-line unbonded tendons.Elastic-perfectly plastic constitutive models with the Ottosen's and the Von-Mises criterion were chosen for the concrete and the steel bar.Unbonded tendons were simplified as varying force boundary conditions while a smeared crack model was introduced to simulate the crack propagation.Nonlinear FEM equations were solved by the Euler-Newton iteration method.In order to verify the FEM model,a 4200mm span simply supported specimen was tested to failure by 2 concentrated loads locating at 1/3 span.The analytical load-deflection curve has shown excellent consistency with the experimental result,especially,the FEM model can figure out the characteristics of the load-deflection curve such as the 2 inflection-points representing the concrete crack and the yield of the rebar,which indicates that the proposed nonlinear FEM model is reasonable and practical.


This article will introduce the reader to the fundamental chemical features of the FWA currently being used or developed, show how the chemical features impact the whitening performance at all stages of the papermaking process, and give several alternatives to achieving a given whiteness/brightness target.


Since the emergence of Ethereum, blockchain-based decentralized applications (DApps) have become increasingly popular and important. To balance the security, performance, and costs, a DApp typically consists of two layers: an on-chain layer to execute transactions and store crucial data on the blockchain and an off-chain layer to interact with users. A DApp needs to synchronize its off-chain layer with the on-chain layer proactively. Otherwise, the inconsistent data in the off-chain layer could mislead users and cause undesirable consequences, e.g., loss of transaction fees. However, transactions sent to the blockchain are not guaranteed to be executed and could even be reversed after execution due to chain reorganization. Such non-determinism in the transaction execution is unique to blockchain. DApp developers may fail to perform the on-chain-off-chain synchronization accurately due to their lack of familiarity with the complex transaction lifecycle. In this work, we investigate the challenges of synchronizing on-chain and off-chain data in Ethereum-based DApps. We present two types of bugs that could result in inconsistencies between the on-chain and off-chain layers. To help detect such on-chain-off-chain synchronization bugs, we introduce a state transition model to guide the testing of DApps and propose two effective oracles to facilitate the automatic identification of bugs. We build the first testing framework, ÐArcher, to detect on-chain-off-chain synchronization bugs in DApps. We have evaluated ÐArcher on 11 popular real-world DApps. ÐArcher achieves high precision (99.3%), recall (87.6%), and accuracy (89.4%) in bug detection and significantly outperforms the baseline methods. It has found 15 real bugs in the 11 DApps. So far, six of the 15 bugs have been confirmed by the developers, and three have been fixed. These promising results demonstrate the usefulness of ÐArcher.


A tube bending machine with rotary arms carrying a bending moment roller and a bending fulcrum roller has arm shafts mounted for axial movement. The arms are rotated for the tube bending action, whereby the bend so made in the tube lies in a predetermined non-planar arc. The arm shafts are turned by a pinion engaged by a rack and are moved axially by suitable pins engaged in cam slots with the rack and the cam slots all being moved simultaneously. In order to retain the tube in proper location or position during the trusts of non-planar arc bending there may be included more than one roller.


The magnitude of the measured geomagnetic index increases when the Coronal Mass Ejections occur on the Sun's surface. The abrupt increase in the geomagnetic index has seriously impacted the accuracy in the forecast of the activity of the next solar cycle. A method is proposed to filter the effect from the Coronal Mass Ejections. The correlation between the geomagnetic index and the activity of the subsequent solar cycle is found to have drastically improved with the proposed scheme. A strong correlation between the maximum amplitude RN of a solar cycle N and its pre-cycle coronal mass ejections adjusted monthly geomagnetic activity index has been qualitatively determined, as illustrated by an impressive correlation coefficient of 0.91+0.09-0.12, with its statistical significance estimated at 4.3 σ. The corrected data have significantly improved the correlation between the observed variables from their original un-corrected case of 0.63 ± 0.23. Our result indicates that the upcoming solar cycle, estimated at R25 = 147 ± 30, would be stronger than the current waning solar cycle 24. In a related calculation, the magnetic poles reversals occurring in the solar cycles 21 and 22 are reproduced numerically from Maxwell's electromagnetic equations.


The primary purpose of this investigation was to determine the prevalence and spectrum of asymptomatic sonographically determined structural changes in the plantar fascia and plantar heel pad among experienced runners without a history of heel pain.


A new gillnet made from multiple mesh sizes ranging from 125 to 180 mm of stretched mesh (experimental gillnet) was tested under commercial fishing conditions to compare the fishing performance with that of conventional gillnets with a 125 mm mesh opening (control gillnet). Catch efficiency and size selectivity between the two gillnet types were evaluated throughout one year of fishing in three different locations in the waters of Vietnam. Experimental gillnets caught narrow-barred Spanish mackerel (Scomberomorus commerson), spotted mackerel (Scomberomorus guttatus), and wahoo (Acanthocybium solandri) in comparable amounts to the control gillnets, with the moon phase, month, and depth explaining some of the variation in the catch per unit effort (CPUE). An analysis of the size-dependent catch comparison rates and selectivity parameters showed that the experimental gillnets captured a wider range of narrow-barred Spanish mackerel sizes, but with a substantial proportion of individuals larger than those caught by the control gillnets. This is of higher weight per unit effort, and fishing enterprises therefore could improve their economic benefits by using modified gillnets with multiple mesh sizes. Our findings also support the biological and environmental benefits of the modified gillnet size selection, which might also extend to other species.


Two similar solar drying units were designed, constructed and evaluated for drying basil leaves (Ocimum basilicum L.) as a medicinal and aromatic plant at initial moisture content of 590.73% (d.b) or 85.52% (w.b) under Fayoum conditions by using heated air. Each drying unit consists of a flat-plate solar collector, which oriented and tilted with an optimum tilt angle and attached with drying chamber. The drying experiments were carried out to examine the effect of basil leaves thicknesses (2, 4 and 6 cm) and airflow rate (0.015 and 0.025 m3.sec-1) on the basil leaves drying rate. The obtained results indicated that the daily average total solar radiation flux incident on the tilted solar collector surface (29.30 MJ. m-2.day-1) was greater than that incident on the horizontal surface (24.30 MJ.m-2.day-1) by 24.58%. The output higher air temperatures were obtained at the lower airflow rate whereas; the energy gained to the air from the solar collector was relatively higher at the higher airflow rate as compared with the lower airflow rate. Consequently, the solar collector with the higher airflow rate increased the overall thermal efficiency by 5.46% as compared to the lower airflow rate. The moisture content of dried basil leaves was strongly affected by the basil leaves thickness and the airflow rate. The final moisture content of dried basil leaves ranged from (11.52% to 14.58% d.b) depending on the drying temperature cycle. Very small changes were observed in the colour and shape of heated-air dried basil leaves as compared to that dried at direct sun rays. The essential oil contents of dried basil leaves were slightly higher for the drying unit with the higher airflow rate as compared with the corresponding values obtained from the drying unit with the lower airflow at all basil leaves thicknesses.
 While on Contrast, total chlorophylls contents were slightly higher for the drying unit with the lower airflow rate as compared with the corresponding values obtained from the drying unit with the higher airflow at all basil leaves thicknesses. Effect of the individual variables (airflow rate, basil leaves thickness, moisture removed, and  their interactions) on the drying rate was statistically analyzed. Under the conditions of this study, the optimum depth to dry basil leaves by using heated air is 4 cm.


The cases of missing children are a major concern now a day.This paper tells us about the android application which has features of tracking the children,the exact location of child can be tracked by GPS service. GSM will be used for network services and it also provides internet. Arduino will also be used as a microcontroller that can sense and control objects in the child's module.The paper is aimed to prevent child kidnapping and trafficking.


WHEN I first began to study the history of the lepidoptera, it was difiicult to learn from any quarter how many molts lepidopterous larvae underwent. :No one to whom I could apply could tell with any assurance of certainty what was the number of molts among the butterflies, and authors either disagreed or were silent on the subject. Burmeister (Lond. 1836, page 431) says " The caterpillars of the butterflies nolt, according to Kirby and Spence, frequently; but thrice according to Ctvier. The caterpillars of the noctuae, on the contra'ry, molt four times;" etc. Boisduval (Spec. Gen., v. 1, p. 46) says: "These molts are more or less numerous according to the family;the rhopalocera passing ordinarily three and four; the greate[ part of the heterocera four, except some clothed species, which pass from seven to eight." Kirby and Spence (Introd. to Ent. Lond. ed., 1856 p. 36) speak of ' butterfly caterpillars throwing off three or more successive skins." Westwood (Brit. Butt., v. 1, p. 6) says They cast their skins several times." Harris (Ins. injur, reg., ed. 1862, p. 259) says: " Caterpillars usually change their skins about four times," referring to caterpillars generally. So it will appear that, twenty years ago, no definite information was to be had on the subject. It was the custom when larvae were described, if any mention of stages earlier than the last, or mature, was made, to say, young larva," 'half grown," etc., with no reference to the number of molts. During these years, and indeed since 1870, I have bred from the egg many species of butterflies, as PAeLIOS 6, viz. ]ax, philenor, asterias, troilus turnus, cresphontes ; PIEaIS 3, protodice, oleracea rapae ; COLAS 2, eurytheme, philodice ; TERIAS 1, nicpe; DANA,S 1, archippus; Alcys 7, diana, idalia, cybele, aphrodite, egleis, myrina, belona; EVeTOn-


The valence electronic structures of the dental gold alloys, type 1, type 3, and K14, and their interaction with L-cysteine have been studied by ultraviolet photoelectron spectroscopy with synchrotron radiation. It was found that the electronic structures of the type-1 and type-3 dental alloys are similar to that of polycrystalline Au, while that of the K14 dental alloy is much affected by Cu. The peak shift and the change in shape due to alloying are observed in all the dental alloys. It is suggested that the new peak observed around 2 eV for the L-cysteine thin films on all the dental alloys may be due to the bonding of S 3sp orbitals with the dental alloy surfaces, and the Cu–S bond, as well as the Au–S and Au–O bonds, may cause the change in the electronic structure of the L-cysteine on the alloys.


The growing interest in the Radio Frequency Identification (RFID) technology is giving rise to new applications, in particular for the identification of metallic objects. This interest has initiated the development of new designs for RFID tag antenna. This paper presents a UHF miniaturized patch antenna aimed at this application. The patch antenna is fed by a balanced feed to avoid a cross-layered construction and matched with a stub. Its miniaturization is achieved by inserting a u-shaped slot in the radiating patch.


Field and track sport is the product of human social activities and has a long history in China and changes with the change of times. Investigation into the origin, formation of field and track sport has positive significance for the promotion of people's health.


Faith and liturgy constitute "two complementary aspects of the life of the Church" (SC 6). That is why the Eucharist, the celebration of which is the main liturgical action of the Church, constitutes "the source and at the same time the summit of the whole of Christian life". It is in the sacrifice of the Mass that the mystery of the Eucharist is re-vealed, because it is a commemoration, a celebration and a perpetuation of the Mystery of Christ in which He makes Himself present. During its celebration, the transubstantiation of bread and wine into the true Body and true Blood of Jesus Christ takes place. It is due to this that the Eucharist becomes the greatest and most precious gift which our Saviour left us before His death. A gift which constitutes the summit of all good and the aim of all man's desires; a gift in which is found "the whole spiritual good of the Church" (EdE 1; PO 5). The Church does not exist without the Eucharist, and only the Church celebrates it. It is during the celebration of the Mass that God sanctifies the whole of humanity and the who-le world in becoming one with them and by bestowing His grace upon them. It is thanks to the Eucharist that the faithful not only achieve perfect communion with the triune God, but also unite with neighbours in building and strengthening in this way the community of the Church.


The article discusses the problems of modernization of higher vocational education in the Russian context of globalization of the world labor market; proposes the model for the integration of university resources in the form of the education network; and views the peculiarities of training at the highest stage of vocational education.


Citizenship was traditionally conceived of as an inclusion or exclusion factor in the relationship between citizens and foreigners with regard to entitlement to rights. It plays a vital historical role in family matters and, more generally, in matters relating to the civil status of people. This arises out of the idea that a national court, in the fi eld of jurisdiction, is best suited to rule on such notions for reasons of cultural or spiritual affi nity. Briefl y mentioning the Italian situation by way of introduction, the criterion of citizenship was rigorously and forcefully advocated by Pasquale Stanislao Mancini from the middle of the nineteenth century. Mancini directly inspired the fi rst uniform code of law with regard to both the range of jurisdiction and determination of applicable law by Italian courts, and the Italian legislature has always remained true to his teachings. Not even the study Committee on Law 218/19951 gave any serious consideration to reviewing this criterion. The criterion of citizenship has therefore held fi rm as a fundamental factor even though certain far from irrelevant changes have been introduced in practice. In procedural terms, a defendant's Italian citizenship is not in itself a general entitlement to jurisdiction (compare Article 3, paragraph I of the 1995 law with Article 4 of the 1940 Code of Civil Procedure) yet still retains an extremely important role in special rules covering the many issues involved in personal status, as will be seen shortly. Subsidiary criteria have been introduced in terms of the applicable law: examples include relationships between spouses of different nationalities, which are now subject to the law of the state where


Digital learning is becoming a prevalent everyday human behavior. Effective digital learning services are integral for educational innovation and constitute competitive advantages for education businesses. Quality management in e-learning research and development is thus of utmost importance and needs both strong conceptual and empirical underpinnings. On the one hand, this work delineates a new model that conceptualizes main critical issues in e-learning research and development projects. The model will foster substantial progress in evaluation and theory development of digital learning. On the other hand, the evaluation of how central features of digital learning services affect learning is indispensable. Here, empirical studies will investigate three key stages of learning: the initial situation, the learning procedure, and the assessment procedure. With regard to the initial situation, how do existing learner characteristics relate to learning performance in digital learning modules? Second, how do visual features of the digital learning content affect the visual attention, cognitive load, and learning performance of the users? Third, how do additional information in textual feedback affect the learning performance in digital multiple-choice quizzes? Overall, this work presents a new model for the systematic evaluation of e-learning and investigates key learning stages to illustrate the importance of developing evidence-based guidelines. Turning both approaches into common practice in e-learning research and development will substantiate theory development, quality management, and project success.


D (DEHP) is the most commonly used plasticizer for polyvinylchloride (PVC), added to improve the flexibility of the material . Many medical tubings and storage bags, such as blood lines in hemodialysis (HD) and bags for continuous ambulatory peritoneal dialysis (CAPD) fluid are made of PVC. In these devices, the plasticizer may amount to up to 40% of the material (1). Since DEHP is not chemically bound to the polymer, it leaches out of the plastic matr ix and therefore can be found nearly ubiquitously in the environment. It has been detected in air, water, soil and food. As a consequence, DEHP is incorporated in the human body and can be detected in body fluids and tissues (2). In spite of its widespread use, little is known about either the extent of exposure or the metabolism in human individuals, particularly in those with a high level of exposure, such as pat ients with end-stage renal disease (ESRD).


encyclopaedic survey of the world and its peoples. It was supposed by GaudefroyDemombynes in his partial translation, L'Afrique, moins C Egypte, Paris, 1927, at p. ii, that ' Le masalik a done ete sans doute ecrit entre les annees 1342 et 1349'—a supposition which, as will appear, cannot be wholly correct. The portion of the text here presented consists of two chapters (qism I, naw' 2, bdbs vi and vii), the first dealing with the territories of the Mamluk sultanate, i.e. Egypt, Syria and the Hijaz (sic, in fact the two Holy Cities), the second with the Yemen. The data provided were extensively quarried by the great compilers of the next period, al-Qalqashandl (d. 821/1418), al-MaqrizI(d. 845/1442), and al-SuyutT(d. 911/ 1505), and the editor has meticulously indicated their borrowings in his footnotes. Al-'Umarfs account has, however, an immediacy which is lacking in the later writers; he is not compiling a section of a chancery manual but describing the court and officials of al-Nasir Muhammad as they existed at the very time of his writing. The date of this (738/1337-38) is precisely given where in his account of Syria (p. 67) he mentions an expedition to Lesser Armenia (bildd Sis) in that year. The chapter on Egypt and Syria was therefore written while al-'Umarl was still in office as his father's deputy. The date of writing has perhaps a further significance in connexion with al-'Umarfs phraseology at this point; he speaks of ta'lifl hadhal-kitab not hddhSl-bdb. The implication may be that this bob was originally produced as an independent monograph on the kingdom of al-Nasir Muhammad, and only at a later date incorporated in the more widely ranging Masalik al-absdr. Two points of detail may be noted. The punctuation and lay-out of the text on p. 44 misleadingly suggest that the second and third lines form part of the sultan's 'aldma, which is actually the phrase on the fourth line— Alldhu amalj. On p. 75, the final line of the first paragraph is perhaps the starting-point of the legend of the enthronement of the titular kings of Jerusalem in the lost cathedral of Tyre. The chapter on the Yemen (previously published separately by the editor in 1974) gives an account of the two contemporary, regimes in that territory, the Rasulid kingdom centred in Ta'izz and Zabld, and the Zaydl imamate with its capital at San'a'. Here al-'Umarl obtained his data from oral informants.


As the most popular art category in the contemporary art field, visual art is no longer limited to traditional art categories such as painting, sculpture and photography, but develops into more diverse forms of expression with the continuous iteration of science and technology. As the most cutting-edge and popular concept in the world today, the research, development and application of science and technology have attracted close attention from all walks of life, including management, economy, transportation, education and teaching. However, there is no in-depth and clear research between the concept of metaverse and the concept of metaverse in the art field, especially in the visual art field. We believe that visual art creation under the background of the metaverse will be an important direction of art development in the future, and will also greatly promote the improvement of the visual presentation quality of the metaverse. Therefore, we focus our research in this study on the issue of visual art quality assessment and propose a theory and method for assessing the quality of visual art in a future-oriented metaverse. This method is based on the G1 entropy method in fuzzy mathematics. In our research, we have built a visual art field architecture based on the metaverse. Considering the difference between the traditional visual art evaluation index system and the index system after the introduction of the concept of the future metaverse, we have built a brand-new visual art quality evaluation index system facing the future metaverse. This indicator is composed of four first-class indicators and twelve second-class indicators. We combine the subjective and objective weighting G1 entropy method as the method basis for the quantitative calculation results of the indicator weight. On the basis of quantitative analysis, we propose three-point countermeasures for improving the visual art quality of the future metaverse. Our research makes up for the gap in the theory of visual art quality evaluation after the introduction of the concept of the future metaverse, innovates the analysis of new concepts and the improvement of old methods, builds a new scene of organic combination of new technology and traditional visual art, and provides a new idea for the improvement of visual art quality in the future at home and abroad, It can also provide experience and theoretical support for the academic topic of similar art quality evaluation research at home and abroad.


This talk will present a method that combines optical sectioning of two-photon temporal focusing with lateral super resolution provided by PALM and a virtual volume imaging technique with resolution better than 20nm in three dimensions.


In the Present research the effect of shells powder additive (50,100,150pphr) on scorch time ,cure time of natural rubber was studied .Oscillating Disk Rheometer was used to measuring the above times by specified the behavior of master batch through scorch time. The obtained results shown that the shells powder don't have negative effect on rubber properties during vulcanization ,where the properties was enhanced after added this powder and the best percentage of addition was (100pphr).


A field experiment was conducted to study the nutrients absorption characteristics of six radish varieties in the northwest area of Hebei province.The results indicate that the root yields of the varieties,Chun Guan 35 and Chun hui are the highest,and the yield of Chun xue-sheng is the lowest.There are significant differences among the N,P and K accumulations and distributions in different radish varieties,the varieties of Chun lei,Chun guan35 and Chun hui have the largest accumulations of N,P2O5 and K2O,respectively,and the accumulations of the other two nutrients and as well as the PFP are also higher than those of the other three varieties;The N accumulations of Chun guang and Chun xue-sheng are the lowest and the accumulations of P2O5 and K2O of Chun guan are the lowest.The varieties of Chun guang and Chun guan have higher production efficiency of nutrients and dry matter.In conclusion,Chun hui,Chun guan 35 and Chun lei have high nutrients use efficiencies,while Chun xue-sheng has low nutrients use efficiencies,and Chun guang and Chun guan have higher physiological use efficiencies of the nutrients.


The traditional analytic book-keeping, also known as the method of the analysis centres, although it desires to be a privileged instrument, it proves to be insufficiently adapted to the management of a modern organisation. The main objective of the paper consists in the proposal of a methodology of the costs' study applied to the precise and standardized sterilisation processes. The chosen method was the ABC method because it is an innovative method – which informs upon structure, origin and the costs' causes – and through which both the cost of a complex medical act can be more reliable determined than in the case of the traditional methods and a performing instrument used to the management of the approaches of continuous improvement of the quality.


The University of Missouri-Columbia is investigating improvements to the Rimfire switch developed by Sandia National Laboratories (SNL) D. R. Humphreys et al., (1985). The University of Missouri Terawatt Test Facility (MUTTS) has been constructed to investigate and optimize the switch, both theoretically and experimentally K. R. Lechien et al., (2003). This paper discusses the development of an advanced circuit model and presents several possible switch modifications including a cascaded electrode geometry, outside dielectric material, and advanced triggering methods. In addition, comparisons to past Rimfire models are discussed


Hepsin (encoded by HPN gene) is a type II transmembrane serine protease, which is commonly overexpressed in carcinomas of prostate and breast. Hepsin protein is known to be stabilized by Ras-MAPK pathway signaling, and downstream, this protease regulates the degradation of extracellular matrix (ECM) components and activates growth factor pathways, including hepatocyte growth factor (HGF) and transforming growth factor beta (TGF beta) pathway. However, the impact of the hepsin-dependent signaling on cell proliferation and tumor growth is not well-understood. Therefore, we sought to clarify the role of hepsin during these events using engineered breast cancer cell lines, Hpn CRISPR knockout mouse model crossed with Wap-Myc breast cancer mouse model, and patient-derived explant cultures (PDEC)s from human breast tumors. We isolated Wap-Myc; Hpn-/- mammary tumor cells and made orthotopic transplantation into syngeneic wild-type recipient mice. The resulting Wap-Myc tumors that lack hepsin had reduced size both in primary and metastatic site compared to tumors derived from Wap-Myc; Hpn+/+ tumor cells. This decrease in growth was accompanied by downregulation in TGF beta and EGFR signaling as well as substantial reduction in total EGFR protein level. We further demonstrated that in 3D culture conditions overexpression of hepsin induced cell proliferation, which was TGF beta 1 and EGFR signaling-dependent, while PDECs treated with hepsin inhibitory antibodies and small molecules had decreased EGFR and TGF beta signaling activity and reduction in proliferation marker expression. Taken together, this study demonstrates a role for hepsin as a regulator of cell proliferation and tumor growth through TGF beta and EGFR pathways and may provide an interesting druggable upstream target to inhibit TGF beta and EGFR pathways in breast cancer.
 Citation Format: Topi A. Tervonen, Denis Belitškin, Pauliina Munne, Shishir M. Pant, Ilida Suleymanova, Kati Belitškina, Jeroen Pouwels, Juha Klefström. Serine protease hepsin regulates tumor growth via TGFbeta-EGFR signaling axis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 834.


Introduction. The segment of small and medium-sized enterprises is one of the top priorities for the strategy of economic development of the Russian Federation. Thus, studies on this topic seem to be relevant. The share of small and medium-sized entrepreneurship (SMEs) in the GDP of developed countries ranges from 35 to 65 %, while the share of SMEs in the GDP of the Russian Federation still does not exceed 20 %.
The current challenges affecting the economy of the Russian Federation, including the COVID-19 pandemic and the current geopolitical situation, as well as sanctions against the Russian Federation imposed by other countries, have had a significant negative impact on small and medium-sized enterprises.
Purpose of the study. The purpose of this study was to review and analyze current crisis phenomena and its impact on the development of importing companies from the SME segment in order to identify key areas requiring the development of new approaches to crisis management.
Results and conclusion. Study results show that modern crisis phenomena have had a significant impact on the development of the SME segment, thus forming a completely new market environment. New challenges have affected almost all activity areas of importing companies from the SME segment from the internal management policy (organization of the company's activities and personnel management) to the rules for importing goods, including logistics, calculations, value management, etc.


The invention relates to the technical field of heat-conducting siliconfilms, and discloses a heat-conducting siliconfilm and a manufacturing method of the heat-conducting siliconfilm. One surface of the heat-conducting siliconfilm is a viscous layer, the other surface of the heat-conducting siliconfilm is a non-viscous layer, the viscous layer comprises liquid state silicone, solid heat conduction powder and fire retardants, the non-viscous layer comprises high-temperature silicon disulfide rubber and solid heat conduction powder, and the high-temperature silicon disulfide rubber is rubber compound. When being used, the heat-conducting siliconfilm with the viscous layer at one surface and the non-viscous layer at the other surface is convenient to disassemble, the problem of non-uniform radiating of heterogeneous materials with different heat condition performances can not be worried when the siliconfilm is used, and as the heat amount is accumulated, the radiating effect of the siliconfilm is greatly enhanced. The coefficient of heat conductivity of the siliconfilm provided by the invention is more than 0.8W/m.K, and can reach more than 5W/m.K according to different types and quantities of the added solid heat conduction powder.


The fractal characteristic of rough surface of service parts is studied based on the power spectrum of its micro surface profile.Then fractal models of 2D and 3D rough surfaces are presented by W-M function and the 2D and 3D service parts rough surfaces are reconstructed.At the same time the rough surfaces reconstructed by the fractal models are filtered by adopting Gauss functions,and reference line and surface for rough surface evaluation are extracted respectively.The paper combines the fractal theory with Gauss functions and applies it to the reconstruction and evaluation.Finally experimental simulation is carried out through compiling MATLAB program,which provides basis for study of surface geometric topography and the joint performance of assembled friction and sealing faces.


Disclosed are a display system and method. The display system comprises a display panel. At least one variable unit and a drive mechanism corresponding to the variable unit on a one-to-one basis are provided within the display panel. When the variable unit works in a placement state, at least two intersection planes and/or at least one stereoscopic object are presented on the display panel. An image processing unit processes an application picture based on the variable unit which currently works in the placement state so as to form a graphically corrected picture, then maps the graphically corrected picture, and forms, in a display region, a display image matching the at least two intersection planes and/or the at least one stereoscopic object.


In most organisms, high affinity ammonium uptake is catalyzed by members of the ammonium transporter family (AMT/MEP/Rh). A single point mutation (G458D) in the cytosolic C terminus of the plasma membrane transporter LeAMT1;1 from tomato leads to loss of function, although mutant and wild type proteins show similar localization when expressed in yeast or plant protoplasts. Co-expression of LeAMT1;1 and mutant in Xenopus oocytes inhibited ammonium transport in a dominant negative manner, suggesting homo-oligomerization. In vivo interaction between LeAMT1;1 proteins was confirmed by the split ubiquitin yeast two-hybrid system. LeAMT1;1 is isolated from root membranes as a high molecular mass oligomer, converted to a ∼35-kDa polypeptide by denaturation. To investigate interactions with the LeAMT1;2 paralog, co-localizing with LeAMT1;1 in root hairs, LeAMT1;2 was characterized as a lower affinity \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{NH}_{4}^{+}\) \end{document} uniporter. Co-expression of wild types with the respective G458D/G465D mutants inhibited ammonium transport in a dominant negative manner, supporting the formation of heteromeric complexes in oocytes. Thus, in yeast, oocytes, and plants, ammonium transporters are able to oligomerize, which may be relevant for regulation of ammonium uptake.


Since the prevalence of acute and especially severe chronic liver diseases of various etiologies increases from year to year, this pathology is recognized as the main burden on health worldwide. Currently, it has been established that the use of drugs based on essential phospholipids and plant origin with antioxidant and hepatoprotective activity is very effective in the prevention and treatment of liver diseases. In this regard, we studied under experimental conditions the effect of phytocomposition of soy lecithin, glycyrrhizic acid, lycopene and ecdysterone (conditional name hepalipin) and proanthacyanidin (conditional name yantacin) isolated from the plant Alhagi pseudalhagi on cytolytic-cholestatic liver damage, as well as on the development of fibrosis. In this study, we evaluated the hepatoprotective and antifibrotic effects of a new combination called Hepatocin obtained in a 1:1 ratio (100 mg/kg of Hepalipin and 100 mg/kg of Yantacin). All the studies conducted were conducted on adult nonlinear rats, while the experimental animals were divided into a control group infected with heliotrin, a substance with hepatotoxic action, a group receiving hepatocin, and an intact group that was not infected with heliotrin at the same time. In the conducted studies, hepatocin significantly inhibited the development of cytolytic-cholestatic liver damage, helped to maintain the functions of the liver synthesizing protein and glycogen, and when administered to experimental animals against the background of a chronic disease developing as a result of damage by heliotrin, it has an antioxidant effect. In addition, the use of hepatocin for more than two months in chronic liver damage or early stage fibrosis led to the restoration of serum enzymes of experimental animals, as well as regulators of cytochrome P450 and b5 fibrogenesis in liver tissues, PCNA, PDGF-BB to levels almost close to the initial (intact) values. Thus, in experimental conditions of chronic severe hepatitis or early stage fibrosis, hepatocin showed statistically significant advantages over Phosphogliv in terms of the intensity of hepatoprotective or antifibrotic action.


The methods and articles of manufacture for storage and transport of nanowires is disclosed. One disclosed method, (a) step to provide a nanowire suspension containing nanowires suspended in a liquid; placing in and (b) a container for the storage and transport of the nanowire suspension It includes, where said container is configured to suppress nanowire aggregation from the nanowire suspension.


Objective To analyze the association of blood uric acid level with the severity of coronary artery stenotic changes, metabolic syndrome (MS), and its components. Methods A total of 343 individuals ( male 223,female 120) who underwent coronary angiography and had complete data on MS and serum uric acid were collected. The severity of coronary artery disease (CAD) was assessed by the coronary stenesis index (CSI). MS was diagnosed according to the Guideline on Prevention and Treatment of Blood Lipid Abnormality in Chinese Adults. Results (1)The mean uric acid level was significantly lower in women than in men [ ( 306.3±76.9 vs 358.9±85.2 ) μmol/L, P<0.01 ]. The prevalence of MS and its components showed no difference between men and women. (2) The uric acid level in women with 3 components was higher than those with1( P<0. 01 ) or 2 ( P<0.05 ) components of metabolic disorders, but not in men. (3) Quartiles of concentration of uric acid were computed. Compared with those in the lowest quartile of uric acid, women in the highest quartile had higher CSI score [ 7.0 (2.5-12.0) vs 2. 0( 0.0-6.0), P= 0. 025 ]. Moreover, the uric acid level was higher in women with multivessel lesions than nonCAD patients [ (327.0±81.9 vs 284.9±78.6) μmol/L, P = 0.033 ]. However, no correlation was found between uric acid level and the severity of coronary artery lesion in men. (4) Logistic regression showed that age (β=0.042, P=0. 007) and dyslipidemia(β=0.836, P=0. 037 ) were the independent risk factors of CAD in men, and hypertension(β=1. 127, P=0.039) and dyslipidemia(β=0.901, P=0.009)in women. Conclusions In women with higher uric acid level, the clustering of metabolic abnormalities was increased, and the coronary artery lesion was more severe. High uric acid level might be a marker of CAD for women.

Key words:
Uric acid;  Coronary artery disease;  Coronary angiography;  Metabolic syndrome


Think back to any history of government or political science class you may have taken, or book you may have read. How far back into history did it begin? Ancient Greece? Mesopotomia? In his new book The Origins of Political Order, political scientist Francis Fukuyama argues that we must go back much further if we are to properly contextualize how political systems are created; he believes that a complete analysis must start with our evolutionary history. In this sweeping magnum opus, the first of a planned two-volume set, Fukuyama emphasizes the "science" in "political science" by creating a model of government and political order which is firmly grounded in human biology. Humans, he asserts, are social and political by nature, making some form of politics inevitable, and any theoretical system that does not take our nature into account is therefore incomplete. While this may not come as a surprise to evolutionists, political science, like so many other academic disciplines, has often viewed its subject matter in a vacuum, without reference to our evolutionary history, so Fukuyama has built an extremely significant bridge with this work. Many foundational political theorists whose writings form the basis of the field, such as Locke, Rousseau, and Hobbes, believed that the "natural" state of humans was isolated and apolitical; in their view, social cooperation and government were fabricated at some point as necessary reactions to the unnatural novelty of society. Fukuyama, by contrast, believes that the origins of politics are within us and have been shaped by evolution, thus providing a crucial link between political science and the natural sciences. Evolutionary perspectives are utilized in two distinct ways in Origins of Political Order. Without using the term, Fukuyama invokes meme theory to draw analogies between biological evolution and the process of political development, showing how governments are dynamic ideas that can spread if successful and vanish if they are not, like organisms subject to natural selection. More excitingly, however, Fukuyama bases his theory of political development deeply in prehuman evolutionary psychology, invoking the concepts of inclusive fitness, kin selection, and reciprocal altruism to show that, contra Hobbes, Locke, and Rousseau, humans are naturally cooperative. He also discusses some of the evolutionary bases of


As VOCs pose a threat to human health, it is important to accurately capture changes in VOCs concentrations and sense VOCs concentrations in relevant areas. Therefore, it is necessary to improve the accuracy of VOCs concentration prediction and realise the VOCs aggregation situation sensing. Firstly, on the basis of regional grid division, the inverse distance spatial interpolation method is used for spatial interpolation to collect regional VOCs data information. Secondly, extreme gradient boosting (XGBoost) is used for spatio-temporal feature selection, combined with graph convolutional neural network (GCN) to construct regional spatial relationships of VOCs, and multiple linear regression (MLR) to process VOCs time series data and predict the VOCs concentration in the grid. Finally, the aggregation potential values of VOCs are calculated based on the prediction results, and the potential perception results are visualised. A VOCs aggregation perception method based on concentration prediction is proposed, using the XGBoost-GCN-MLR method with a scenario-aware approach for VOCs to perceive the VOCs aggregation in the relevant region. VOCs concentration prediction and VOCs aggregation trend perception were carried out in Xi'an, Baoji, Tongchuan, Weinan and Xianyang. The results show that compared with the GCN model, XGBoost model, MLR model and GCN-MLR model, the XGBoost-GCN-MLR model reduces the input variables, achieves the optimisation of the input parameters of the VOCs concentration prediction model, reduces the complexity of the prediction model and improves the prediction accuracy. Intelligent sensing of VOCs aggregation can visualise the regional VOCs. The intelligent sensing of VOCs aggregation can visualise the development trend and status of regional VOCs aggregation and convey more information, which has practical value.


The hypotheses are evaluated that in abdominal pregnancies 1) elevated MSAFP is due to an altered maternal-placental interface, and 2) differences in MSAFP levels may reflect placental location within the peritoneal cavity. A review of 1,193 ectopic pregnancies from 1983-1993 identified three cases of advanced abdominal pregnancy. All three had undergone second trimester genetic amniocentesis for amniotic fluid alpha fetoprotein (AFAFP) and karyotype. The clinical course was reviewed (including presentation and surgical findings). MSAFP was elevated in two of the three cases (3.63 and 4.88 MoM). AFAFP and fetal karyotype were normal in all three cases. Elevated MSAFP values were associated with more extensive visceral implantation, longer surgical operative time, greater blood loss and transfusion requirements. Abdominal pregnancies with elevated MSAFP appear to have more extensive placental involvement of the abdominal viscera; this would, in fact, account for the elevated MSAFP values given the normal AFAFP.


Diabetes mellitus (DM) is a chronic metabolic disease. It was caused by lack of insulin or cells cannot use insulin so that blood glucose becomes high (hyperglycemia). And it will cause other systemic diseases of the disease (metabolic syndrome) that can increase the factor of death. Coffee is one of the consumed plants that contain antioxidants and chlorogenic acid that have a role as antihyperglycemia. In other hand Jambi as one of the coffee producing regions (arabica, robust and liberica) in Sumatra and it has a potency as a coffee producer. In addition, people's habits in consuming coffee have the opportunity to be one solution in overcoming diabetes. This study aimed to determine the effect of hyperglycemia disease. The method was experimental with 5 treatments (metformin, arabica, robust, liberica and aquades) and 3 replications. Before threatments mice were injected with streptozotosin in order to be hyperglycemia, then mice with blood glucose ≥ 116 mg / dl were measured their blood glucose, weight and made the histology of the liver. Then the datas were analyzed using ANAVA. The results showed that Jambi coffee (arabica, robust and liberica) can lower blood glucose levels hyperglycemia mice until day 16. And the treatment with liberica coffee lowers hyperglycemia with the lowest glucose levels. While the histological features of mice liver showed lower cell degeneration especially in mice by coffee treatment, especially arabica coffee.


Can rationality and pragmatism be integrated? By responding to some of the most compelling arguments against the rational paradigm, this paper uses the pragmatism of William James to construct a new notion of pragmatic rationality in planning. This rationality looks towards consequences rather than causes, integrates facts and values, and rejects the search for ultimate foundations.


We propose a wearable, ungrounded haptic display that presents the realistic gravity sensation of a virtual object. We focused on the shearing stress on the fingerpads duo to the weight of the object, and found that the deformation of the fingerpads can generate the reliable gravity sensation even when the proprioceptive sensation on the wrist or arm is absent. This implies that a non-grounded gravity display can be realized by reproducing the fingerpad deformation. According to our observations, we had evaluation tests for device design. We implemented the prototype device which has simple structure using dual motors, and then evaluated the recognition ability of the gravity sensation presented on operator's fingerpads with this method


Following the recent explosion in the number of designs for short-term assays for mutagens and carcinogens it appears worthwhile to take stock of the current situation and speculate about future developments. Over 400 strong, weak and noncarcinogenic compounds have been examined by one or the other of the microbial tests, Drosophila assay, or the DNA fragmentation/DNA repair system of cultured mammalian cells. Between 80 and 90% of examined carcinogens give a positive response if checked with one test. If the results of several tests are pooled, only a very few carcinogens escape detection. In spite of these highly promising results, there is a reluctance on the part of regulatory agencies to accept wholeheartedly the rapid, inexpensives and reproducible short-term bioassays. Why? The phylogenetic relationship betweetl bacteria and man appears for some too remote to permit an extrapolation from microbial tests to human populations. Others doubt the validity of using point mutations as an endpoint, claiming that mutations may not play a role in neoplastic transformation and thus cannot be used as a relevant endpoint. One answer to these heretics could be to rank the various endpoints including, of course, carcinogenicity and to calculate a coefficient of rank correlation. Another answer would be to use several well chosen, short-term assays which complement each other. The Salmonella mutagenicity test in combination with activation systems (I) and the recombination assay of Kada (2) can be applied to mutagens/carcinogens found in the environment, in complex mixtures, or in body fluids of man. DNA fragmentation/DNA repair assays on cultured


Physical properties of lead oxide-silica glasses were studied in an attempt to correlate these properties and explain the anomalies occurring in their temperature and time curves on the basis of the structure of glass as derived in Part I of this investigation. The transformation point is denned as a critical temperature, and an explanation is offered for the dependence of this temperature on heat treatment and conditions of test. The change in the apparent viscosity of a glass fiber with time is explained on the basis of the distorted glass structure. The Adams and Williamson equation for strain release is adapted to substantiate the theory of the structure of glass consisting of a continuous, randomly oriented, three-dimensional network of atoms.


Metamaterial meshes are artificial thin metal film structures with a periodic arrangement of holes. Here we describe the development of metamaterial meshes for applications as sensors, using high-accuracy and low-cost fabrication methods to enable disposable devices. Small liquid droplets from dispensers were used to characterize the devices. The results demonstrate that detection of sub-microliter liquid specimens is possible. The process was considerably simpler than conventional techniques, such as staining or mass balance measurements. Our results show that these metamaterial meshes have potential applications as sensors, in particular for rapid tests and calibration of multi-channel dispensers.


Suppose $D$ is a suitably admissible compact subset of $\mathbb{R}^k$ having a smooth boundary with possible zones of zero curvature. Let \mbox{$R(T,\theta,x)= N(T,\theta,x) - T^{k}\mathrm{vol}(D)$,} where $N(T,\theta,x)$ is the number of integral lattice points contained in an $x$-translation of $T\theta(D)$, with $T >0$ a dilation parameter and $\theta \in SO(k)$. Then $R(T,\theta,x)$ can be regarded as a function with parameter $T$ on the space $E_{*}^{+}(k)$, where $E_{*}^{+}(k)$ is the quotient of the direct Euclidean group by the subgroup of integral translations, and $E_{*}^{+}(k)$ has a normalized invariant measure which is the product of normalized measures on $SO(k)$ and the $k$-torus. We derive an integral estimate, valid for almost all $(\theta,x) \in E_{*}^{+}(k)$, one consequence of which in two dimensions is that for almost all $(\theta,x) \in E_{*}^{+}(2)$, a counterpart of the Hardy circle estimate \mbox{$(1/T)\int_{1}^{T} |R(t,\theta,x)\,dt| \ll T^{\frac{1}{4} +\epsilon}\;$}is valid with an improved estimate. We conclude with an account of hyperbolic versions for which, drawing on previous work of Hill and Parnovski \cite{hill-parnovski}, we give counterparts in all dimensions, for both the compact and non-compact finite volume cases.


Polymer solar cells (PSCs) are a promising alternative for low-cost renewable energy due to their solution-process, flexibility and large-area fabrication. To improve power conversion efficiency (PCE) of PSC, a hole transport layer (HTL) is usually inserted between anode and active layer to enhance hole carrier collection. In this contribution, the utilization of solution processable self-doped sulfonic acid ring-substituted polyaniline (SPAN) thin film as the HTL in inverted PSC (i-PSC) composed of poly(3-hexylthiophene) (P3HT):[6,6]-phenyl-C61-butyric acid methyl ester (PCBM) bulk heterojunction is demonstrated. The i-PSC with SPAN as the HTL exhibits an improvement over that with PEDOT:PSS (from 3.30 ± 0.14% to 3.54 ± 0.11%) due to higher conductivity and better film quality of SPAN relative to poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS), suggesting that SPAN can be a promising alternative to PEDOT:PSS as the effective HTL for i-PSC.


We describe a system for extracting concepts from unstructured text. We do this by clustering document words and then assembling a structure which relates these words semantically. The clustering process identiies words which co{occur across a set of documents and creates groups of words which suggest a semantic context common across the document set. This context is formalized by identifying semantic relationships between the cluster words using a lexical database to build a Semantic Relationship Graph (SRG). This SRG is a directed graph which conveys a robust representation of the sub{ and super{class relationships between the correct word senses. We show how this process can be applied to a user{selected set of HTML documents; the SRGs can subsequently aid in searching the World Wide Web for documents which are similar.


Radical cystectomy (RC) remains a morbid procedure. The use of Enhanced Recovery After Surgery (ERAS) pathways has proven to reduce care time and post‐operative complications after colorectal surgery. There is a high potential for reducing morbidity associated with RC by utilizing ERAS in this setting. The purpose of this review is to examine the current evidence for ERAS in preoperative, intra‐operative and post‐operative setting of care for RC patients and to propose ERAS evidence‐based protocol for patients undergoing RC in the Australian and New Zealand environment.


Grateful is one kind of civilization, feels grateful is one kind of personal character.The human had has felt grateful the heart, the human and the human, the human and the nature, the human and the society also can become more harmonious, kinder.


In this paper we propose a new dataset for information extraction from news web pages. Accurate collection of news articles is necessary to build systems that aggregate and analyze data from a large number of news sources. However, existing news page datasets are designed for the problem of article content extraction and do not consider other metadata such as dates or authors, while modern generic approaches for structured web data extraction are evaluated on other domains, mostly e-commerce products websites. Our dataset contains 724 web pages from 114 Russian news websites. On each page we manually annotated title, text, publication date, tags and other article attributes. We describe data collection and annotation process and demonstrate evaluation results for open source tools and neural network based approaches. The dataset is publicly available on GitHub.


(A) 35 to 65 parts by weight, preferably 45 to 65 parts by weight, most preferably 50 to 60 parts by weight of the low molecular weight polyethylene having a weight average molecular weight (Mw) of 20,000 to 90,000 g / mol; (B) the first high molecular weight polyethylene having a weight average molecular weight (Mw) in excess of 150,000 to 1,000,000 g / mol, or the first ultra high molecular weight polyethylene having a weight average molecular weight (Mw) in excess of 1,000,000 to 5,000,000 g / mol, To 40 parts by weight, preferably 5 to 30 parts by weight, and most preferably 5 to 20 parts by weight; And (C) the second high molecular weight polyethylene having a weight average molecular weight (Mw) of more than 150,000 to 1,000,000 g / mol, or the second ultra high molecular weight polyethylene 20 having a weight average molecular weight (Mw) of more than 1,000,000 to 5,000,000 g / To 60 parts by weight, preferably 25 to 60 parts by weight, and most preferably 35 to 55 parts by weight, wherein the molecular weight distribution of the multimodal polyethylene composition is 10 to 25, preferably 10 to 20, Isocratic crystallization half time of the multimodal polyethylene composition is determined by differential scanning calorimetry to be 7 minutes or less, preferably 6 minutes or less, preferably 2-6 minutes at a temperature of 123 DEG C, and at a temperature of 220 DEG C Wherein the spiral flow length is greater than or equal to 200 mm, preferably between 250 and 400 mm, and a screw comprising the multimodal polyethylene composition. Relate to.