The Ti-6Al-7Nb alloy was specially developed to replace the well-known Ti-6Al-4V alloy in biomedical applications due to supposed cytotoxicity of vanadium in the human body. This alloy is normally fabricated by conventional ingot metallurgy by forging bulk material. Nevertheless, powder metallurgy techniques could be used to obtain this alloy with specific properties. This is because by changing the processing parameters, such as the sintering temperature, it is possible to vary the porosity level and to tailor the final properties. This work deals with the production of the Ti-6Al-7Nb alloy by means of the master alloy addition variant of the blending elemental approach. The powder is processed by means of different powder metallurgy routes considering diverse processing conditions for each method. The materials are characterised in terms of microstructural features, relative density and hardness. Homogeneous microstructures as well as properties comparable to those of the wrought alloy are generally obtained.


This essay illustrates two conversational principles: the Cooperative Principle and Politeness Principles and how they can be applied to language teaching field.


The microstructures of laser remelting area on Zn Al based ceramic thin film were analyzed by means of LM and SEM. Its formation mechanism is discussed in this paper.


We have designed and fabricated a linear drive amplifier with a novel intermodulation distortion (IMD) canceller using 0.18 ㎛ CMOS process. The drive amplifier with IMD canceller is composed of a cascode main amplifier and an additional common-source IMD canceller. Since the IMD canceller generates IM3 (3 rd -order imtermodulation) signal with 180° phase difference against the IM3 of the cascode main amplifier, the IM3 power is drastically eliminated. As of the measurement results, OP1㏈, OIP3, and power-add efficiency are 5.5 ㏈m, 15.5 ㏈m, and 21 %, respectively. Those are 5 ㏈, 6 ㏈, and 13.5 % enhanced values compared to a conventional cascode drive amplifier. The IMD3 of the drive amplifier with IMD canceller is enhanced more than 10 ㏈ compared to that of the conventional cascode drive amplifier for input power ranges from -22 to -14 ㏈m.


Post-Variscan dolomites occur in Zn-Pb-Cu veins, Crush-leach, stable isotope (oxygen and carbon) and microthermometry analysis of the fluid inclusions in dolomites, Highly saline H2O-NaCl-CaCl2-MgCl2 fluids occur in inclusions, isotopic fluid composition indicate that the fluid was derived from evaporated seawater, rock-buffering explains the isotopic composition at low w/r ratios, fluid-rock interactions largely controlled the fluid chemistry (K, Li, Br and Na contents, K/Cl, I/Cl and Li/Cl molar ratios). A permeable basement and fractured sedimentary sequence enhanced the general nature of the fluid system. Fluid characteristics are comparable with the main post-Variscan fluid flow systems in the Polish (Cracow-Silesian ore district) and German sedimentary basins.


Technological developments provide a solution to geographical problems and reduce the human error factor in legalizing diplomas. This advantage is the basis for the Ganesha University of Education to apply the application because it has many alumni who do not only come from the surrounding area. This application was launched starting November 4, 2019 with the address https://legalisir.undiksha.ac.id. This research tests the service by testing the performance of website access, speed of the server and testing the system when access occurs in high numbers. This test focuses on using several website-based applications, namely GTmetrix, and LoadImpact (k6.io) by using their cloud server to get accurate results. The first test with the GTmetrix application generates a performance value for PageSpeed with a value of F (47%) and YSlow with an E value (53%) and has a 2.5 seconds access time, the total size of the intended page is 1.22MB. For the results of the load test the simulation results obtained as many as 55,138 requests with detailed failures of 0, the highest number of requests that can be done per second is 87 and with an average response time obtained is 87.84 milliseconds. This study concludes that Undiksha legalized system is classified as good because it has a loading time of under 3 seconds according to the reference because it is supported by a reliable server implementation.


The complex fac-(η2-C60)(η2-dppe)Cr(CO)3 (dppe = 1,2-bis(diphenylphosphino)ethane and C60 = [60]fullerene) reacts with piperidine (pip) to produce fac-(η2-C60)(η1-pip)2Cr(CO)3. The reactions are first order with respect to [ fac-(η2-C60)(η2-dppe)Cr(CO)3] under flooding conditions where [pip] ≫ [ fac-(η2-C60)(η2-dppe)Cr(CO)3]. The pseudo-first order rate constant values (k obsd) are [pip]-dependent. Curved (upward) plots of k obsd versus [pip] and linear plots of k obsd versus [pip]2 indicate that the piperidine-assisted dppe displacement from fac-(η2-C60) (η2-dppe)Cr(CO)3 is second order with respect to [pip]. The proposed mechanism involves a [60]fullerene-stabilized intermediate.


This paper presents a design optimization of a novel electromagnetic MEMS energy harvester by using a fine patterned NdFeB array with a serpentine shaped coil for gathering electromotive force. The serpentine coil can be easy to be fabricated in comparison with a spiral coil that fabricated in the previous work. The magnetic flux density is calculated by FEM analysis. The various line-and-space parameters of the magnet and the coil are investigated for the optimization of the output power. The electromotive force and the output power are calculated by a theoretical equation. As a result of optimization, the electromotive force of 31.3 mV and the output power of 0.722 μW are obtained when an applied vibration amplitude is ±200 um at 595 Hz with magnet line and space of 70 μm.


supposed to be able ever to "be unaware" of the extent of her or his freedom! Had I thought that this was a major message of Being and Nothingness, regardless of its other shortcomings and of its merits, I could not have managed to teach it with a straight face. Flynn's correct insistence on the allpervasiveness of human responsibility in Sartre's thinking, which follows from the thesis of the in-principle comprehensibility of our freedom, does not rest on a completely contrary-to-fact belief in the all-pervasiveness of lucidity. More careful discussion of the possible meanings of "to know," "to be aware," etc., might have been in order here. But such exaggerations, as I regard them, do not detract from Busch's competence as a very broadly knowledgeable citer of important Sartrean texts or as a shrewd chronicler of Sartre's overall evolution toward greater philosophical sobriety about "the power of consciousness." He also shares interesting incidental insights with his readers, such as his view of the earlier Sartre as closer to Husserl's personal ethos than were the other existential phenomenologists (pp. 14-15), his attribution to Bergson of greater formative influence on Sartre than the latter ever acknowledged (p. 26), and his refreshing insistence on seeing Sartre's treatment of certain notions, such as that of being-in-itself, as ultimately "muddled" (p. 23). Busch's principal aim, as the footnote text that I first cited from him indicates, is conceptual and methodological clarification of Sartre's intellectual odyssey with respect to consciousness. In accomplishing this somewhat limited aim, he gives little evidence of having been influenced by the increasing suspicion of universalistic, conceptual thinking that Sartre himself evinces in a few of his last texts. Busch has, however, put more or less traditional methods of scholarly philosophical analysis to good use.


The desk culture in vocational-technical institute is characterized by universality in space,complexity in content and authenticity in thought.The phenomenon can be put down to the psychology of the students,the inducement of the desk culture,the emptiness of the students and the lack of moral self-discipline.To solve this problem,emphasis should be put on social morality education,psychological consultation,and classroom teaching and management.


Abstract.Full-scale separation apparatuses were used to process mink and sow manure. Mink manure was pretreated with iron sulfate and polymer; pig manure was pretreated with only polymer. Testing was done to study how adding chemicals affected phosphorus removal. Chemical equilibrium simulations show that raw manure contains several minerals, i.e., struvite, calcium phosphate, and vivianite. The estimated mass of struvite fit well with the amount of magnesium measured in the solid material. The amount of calcium phosphate precipitation depended on the stability constant of the complexes of organic material and calcium ions, estimated at pK = 3.5–4. With polymer addition, it was possible to remove mineral-bound phosphorus but not organic-bound phosphorus and orthophosphate. With iron salt addition, it was possible to remove both phosphorus minerals and dissolved orthophosphate. The molar ratio between orthophosphate and iron ions in the precipitate was measured to be 2:3. These data fit well with the chemical equilibrium simulations, which predicted that vivianite would form when the iron ion concentration increased. The simulation also indicated that the amount of struvite decreased slightly with iron addition. Keywords: Coagulation, Flocculation, Solid-liquid separation, Vivianite, Wastewater.


Overview For decades, the American public and its leaders have demanded improvements in educational outcomes for children and youth, especially disadvantaged children and youth. In response, a variety of education reforms have been implemented across the country, both within classrooms and schools and across schools and community programs. Some of these reform efforts have involved greater use of extended learning time for students – a longer school day or year, for example, or opportunities to expand learning into the out-of-school time hours. As schools, communities, and funders consider investments in extending learning opportunities, they are right to ask for evidence of the effectiveness of various approaches and to seek lessons learned from others' experiences in this field.


Cognitive radio (CR) is an intelligent wireless communication system which can dynamically adjust the parameters to improve system performance depending on the environmental change and quality of service. The core technology for CR is the design of cognitive engine, which introduces reasoning and learning methods in the field of artificial intelligence, to achieve the perception, adaptation and learning capability. Considering the dynamical wireless environment and demands, this paper proposes a design of cognitive engine based on the rough sets (RS) and radial basis function neural network (RBF_NN). The method uses experienced knowledge and environment information processed by RS module to train the RBF_NN, and then the learning model is used to reconfigure communication parameters to allocate resources rationally and improve system performance. After training learning model, the performance is evaluated according to two benchmark functions. The simulation results demonstrate the effectiveness of the model and the proposed cognitive engine can effectively achieve the goal of learning and reconfiguration in cognitive radio.


The main channel of the free-flowing section of the Danube River downstream of Vienna (Austria, Europe) is impacted by impoundments upstream and has been altered by flood protection measures, by bank stabilization and maintenance of a navigation channel. In order to provide information for planning of restoration measures, and due to the high indicator value of the fish assemblage, we investigated habitat suitability and patterns of habitat preference of the sublittoral fish assemblage within a selected, representative river reach. The hydraulic information from a 3D numerical model with a high spatial resolution was combined with precise positions of caught individuals. The recording of the position of caught individuals was possible by the application of a newly developed technique which complements standard boat-electro fishing procedures. Combining hydraulic conditions from the hydrodynamic model with the abundance of fish enables the projection of information based on sampling points to area, and to simulate the potential impact of different restoration measures on habitat availability and habitat quality, and may therefore serve as a basis for conservation issues.


Composite polymer membrane electrode has been fabricated on platinum foil using electrochemical deposition of the pyrrole and aniline as monomers. The electroreductive behavior of cefdinir was investigated and two irreversible well-defined cathodic peaks were observed at composite polymer membrane electrode. From the electrochemical response the main reduction steps were found to be related to the reduction of C=N and C=C group. A fully sensitive and reproducible voltammetric procedure for the trace determination of the pharmaceutical formulation at the composite polymer membrane electrode has been developed.


In order to meet the needs in designing the active laser reconnaissance system for practical combat,the operation range formula of the system is deduced by analyzing the focus deviation of optical channel with cat′s eye effect.By numerical simulation with MATLAB,the relationship curves of the operation range with the sensitivity of CCD,diverging angle,laser power and visibility are given.The research is helpful in designing the active laser reconnaissance system.


The angular pattern of sunlight reflected by snow is altered by surface roughness, which in the interior of Antarctica is usually in the form of meter-scale longitudinal erosional features (sastrugi), whose axes align with the direction of strong winds. The bidirectional reflectance distribution function (BRDF) changes over the course of a day as the solar azimuth changes relative to the sastrugi axis. The normalized BRDF, or "anisotropic reflectance factor" R, was measured at South Pole Station from a 22-m tower at 600, 660, and 900 nm wavelengths. The R pattern was similar at the three wavelengths; it probably varies little from 300 to 900 nm. Measurements were made at solar zenith angles θ0 from 67° to 90°, over the full range of viewing zenith angle (θr), azimuth angle between Sun and view (ϕ), and azimuth angle between Sun and sastrugi (ϕsas). Variation of R with ϕsas was notable; sastrugi oriented perpendicular to the solar beam cause a reduction of the forward peak, and sastrugi at an oblique angle cause R to lose its symmetry about the solar azimuth. However, the effects of sastrugi are mostly restricted to large viewing zenith angles, so remote sensing of albedo and atmospheric properties can be carried out accurately without knowledge of sastrugi height and orientation if only near-nadir views are used. This recommendation is opposite that for observations of broken clouds over dark surfaces, for which large θr is preferred. A parameterization of R is developed, valid for viewing angles θr ≤ 50°. Sastrugi can cause a reduction of the snow albedo by altering the angle of incidence and by trapping of photons. For the small sastrugi of the Antarctic Plateau, the albedo is unaffected at visible wavelengths but can be reduced by a few percent at near-infrared wavelengths when the Sun is low.


The present study intends to develop an understanding regarding the differences between sons and daughters which exist at socio-cultural level and the relevant Islamic teachings. It contends that most of the social practices are not true representation of Islamic teachings. Religion, nevertheless, remains an integral part of almost every social system: it determines normative structures and their functioning. Exploring both the dimensions---social and religious---further enabled us to have a comprehensive understanding of gender conception. These are also helpful in dispelling the long existing misconceptions which have been leading to various objectionable and staunch practices. Most of the available literature and researches have been consulted to develop an in-depth knowledge regarding the female child whether she is considered as a blessing or curse .It is found that most of the social practices are in contradiction with the Islamic teachings. Flawed interpretations mislead masses and traditional mindsets are usually resistant to change. Islam emphasized on an unbiased stance for male and female conception, only will of God matters in this regard ; however social attitudes are not found the same and deviates from Islamic guidelines in many ways.


Using an effective hadronic Lagrangian with physical hadron masses and coupling constants determined either empirically or from SU(4) flavor symmetry , we study the production cross sections of charm mesons from pion and rho meson interactions with nucleons. With a cutoff parameter of 1 GeV at interaction vertices as usually used in studying the cross sections for J/ψ absorption and charm meson scattering by hadrons, we find that the cross sections for charm meson production have values of a few tenth of mb and are dominated by the s channel nucleon pole diagram. Relevance of these reactions to charm meson production in relativistic heavy ion collisions is discussed.


We set out a simple Bayesian model for turnout at the polls by expressive voters. We show that it mathematically implies the standard empirical findings about turnout. We also show that it implies a new estimator for turnout, "double probit." Applications of the model to large American and Irish datasets demonstrate that the new model gives better statistical fits than conventional probit, more theoretically interpretable coefficients, more stable estimates across different surveys in the same election, and greater ability to forecast turnout patterns in new elections. Prepared for presentation at the Annual Meeting of the Midwest Political Science Association, Chicago, April 12-15, 2007. Copyright by the authors.


Using orthogonal design method of four factors and three levels, make a mix ratio experiment on sleeper concrete of China's railway sleepers, used steam curing concrete early compressive strength (stripping strength) as evaluation index. Study on different experimental factors of water-cement ratio, sand ratio, fly ash and admixture differently influenced on the early strength of sleeper concrete and analyze the difference impact of each factor and level for the orthogonal experiment. The result shows that the admixture is the main factor for early strength of concrete, followed by fly ash, water-cement ratio and sand ratio. It can provide technical guidance for railway sleeper field and has practical value.


As one important part of modern life,advertisement has a great influence on people's daily life,and there are plenty of popular advertisements that have inspired our fascination and fulfilled us with their skillfulness.The Relevance Theory of the Cognitive Linguistics has been regarded as an useful tool for discourse analysis.In this paper,it is to give an analysis of the advertising language from the perspective of Relevance Theory and to discuss the factors that related to the success of one advertisement.


The present study aims at developing a natural partition radiotracer potentially useful for estimating the amount of oil present in a matrix rock. The evaluation of the Residual Oil Saturation (SOR) in oilfields requires that the partition coefficients (Kp) have been previously measured. Tests have been carried with the 222Rn isotope, as the radiotracer. Radon partition coefficients were determined in laboratory tests, in twophase systems of water and either petroleum or other organic species such as toluene, benzene, and octanol. In order to carry out these measurements, a Flow Injection Analysis (FIA) system has be implemented. The tests have been run at a constant flow-rate, varying the residence time and the temperature A Lucas cell system has been utilized for the measurement of the 222Rn specific activities. Key-Words: 222 Rn, Partition coefficient, Flow Injection Analysis, Petroleum.


In this study, a new method was examined that used acoustic emission (AE) monitoring data, in combination with a primary Boundary Element stress analysis, to back-calculate rock mass strength. The presented AE data came from the National Radioactive Waste Repository (NRWR) for low- and intermediate-level waste (LLW/ILW). AE monitoring is able to detect the pre-peak, peak, and post-peak stress changes in rock mass. The presented method used AE monitoring data to back-calculate parameters, such as uniaxial compressive strength and the rock mass deformation modulus. The AE initiation threshold was used to develop an objective function that considered the stress in the rock mass and the rock mass strength. The findings of this research propose that most AE events can be related to the crack initiation threshold, and in space, most of them are located at points away from the excavated walls. In the vicinity of the excavation damage zones around the cavities, the stress conditions beyond the crack damage boundary of the rock mass occur in many areas, leading to significant irreversible deformations. This novel method was demonstrated to aid in the prediction of rock mass strength and is a valuable, non-invasive method for improving the spatial prediction of rock mass parameters, which will lead to safer underground storage facilities.


For many years works on the history of modern China and the Chinese Communist Party have stated that during the Great Revolution Chen Duxiu consistently opposed the peasant movement and belittled the role of the peasantry in the revolution. For his remark that in the key province of Hunan the peasant movement had committed "excesses," he has been attacked for "slandering the peasant movement from a landlord-bourgeois position." In this article, however, a different viewpoint will be advanced. Readers' criticisms are invited.


She received Alice's card and Abe received a card from Tobe. She asks that they send more information on the condition of Florence. She mentions the weather and Willie going to town. She talks about Birdie and Bessie hunting for eggs and the state of the wheat. She says to send Alice home after school is out so she can help Florence, but leaves the final decision with Sis.


This paper describes the on-line teaching strategies for languages adopted at the University of Dalarna (Sweden) and the experience of a collaboration carried out with the Language Centre of the Un ...


The invention discloses an LED street lamp control system based on an electric power carrier communication technology, which is in a three-layer network structure comprising a single lamp controller, a centralized controller and a management center, wherein the single lamp controller takes a singlechip as a core to be in charge of controlling a street lamp and collecting street lamp working parameters; the centralized controller adopts embedded system design, operates a power line carrier technology and carries out group or single control on street lamps in areas according to preset illumination strategy and assistant illumination intensity control strategy; the management center is mainly composed of a personal computer PC and street lamp system management software to display lamp street state (luminance, voltage, current and power) information; and a GPRS wireless transmission technology or Internet network is used for realizing the remote management of the street lamp switch and luminance regulation. Thus, by using the system, operations such as scheduling events, data record reading, event monitoring, warning response and the like can be realized, and historical data can be inquired.


Wireless sensor network (WSN) has become a growing research area due to its tremendous number of applications which can benefit from it. WSN are often deployed in unfavourable environments where an attacker can capture various nodes and replicate them to take over the network. The defence against node replication attacks are few and suffer from high overhead with respect to computation cost and memory. To find the replicas in the network, distributed detection approach is employed. The basic challenge of this approach is to minimize the communication and per node memory costs. With the use of distributed approach the node replicas can be captured efficiently. The results are expected to compare the different variants with respect to communication cost and


Objective To establish a HPLC method for the determination of rutoside in compound rutoside tablets.Methods RP-HPLC method,the analytical column was HYPERSIL ODS-C18(4.6 mm×250 mm,5 μm).The mobile phase consisted of methanol-0.1% phosphoric acid(15∶35).The detector wavelength was set at 359 nm.The flow rate was 1.0 ml/min.The column temperature was at 35 ℃.The injection volume was 20 μl.Results The calibration curve was linear in the range of 0.95~30.4 μg/ml of rutin with correlation coefficient of 0.9999,and the regression equation as Y=99384X-22521.The average recovery of the method was 99.3%,and RSD was 0.70%(n=6).Conclusion The method is quick,accurate,and simple with good repetition.


The invention relates to a method and a device for the interference cancellation in a wireless communication system. The method mainly comprises the following steps carried out by UE: detecting a received signal to obtain related information of a target cell; carrying out channel estimation according to the SSS (secondary synchronization signal) of the target cell; reconstructing a PSS (Primary Synchronization Signal) and the SSS through utilizing the channel estimation; using the reconstructed PSS and SSS to cancel the PSS and the SSS of the target cell in the received signal, so as to obtain a received signal with the interference of the target cell being cancelled; and repeating the steps to the received signal with the interference of the target cell being cancelled until obtaining a received signal with all the searched interferences of the target cell being cancelled. Therefore, the detection performance of common-frequency cells, especially common-frequency adjacent cells with weak signals, can be greatly enhanced.


With the thought that the anticipation of profits from technological innovation is the fundamental motivity of enterprise technological innovation by integrating various factors of that influence the motivity. The needs and the capabilities to carry out technological innovation are the internal factors, the external factors, such as market environment, scientific and technological level, and policies, etc. have influenced over the motivity of technological innovation by working on the internal ones. Finally, pointing out that the influences from regional innovation system on the motivity of enterprise's technological innovation are mainly represented in market environment, technique diffusion and the policies, and so on.


Dr. Herbert F. Schwarz has recently considered the relationship of Anthidium collectum Huard and A. angelarum Titus. After a study of the facts at hand, he says: "I think tliere can be little doubt that the insects represent one species to which the name collectum applies by virtue of priority." From a review of the literature there seems to be no record of the nesting habits of this bee.


Purpose. To evaluate the effect of laser in situ keratomileusis (LASIK) on corneal sensitivity, nerve morphology, and tear film characteristics. Methods. A cross-sectional study design was used. Eighteen patients (eight men and 10 women with a mean age of 36.9 ± 11.2 years) who had undergone bilateral LASIK for low myopia within 18 months of the study and 28 control subjects (16 men and 12 women with a mean age of 27.2 ± 7.7 years) were enrolled. Central and inferior corneal thresholds to mechanical (air) and chemical (air plus carbon dioxide) stimuli were determined by using a staircase technique. Stimuli of a 1-second duration at 34°C were delivered with a CRCERT-Belmonte aesthesiometer. Images of subbasal nerves in the central cornea were captured with confocal microscopy. Nerve morphology was classified as no nerves, short nerves (<175 &mgr;m), or long nerves (>175 &mgr;m), with or without interconnections. Noninvasive tear break up time was measured. The phenol red thread test was used to indicate basal tear secretion. Differences between groups were evaluated with analysis of variance, and associations between variables were evaluated with parametric or nonparametric correlation, when appropriate. Results. Central corneal mechanical sensitivity was significantly reduced in the post-LASIK group compared with the control subjects (P<0.001). Nerve morphology was associated with mechanical threshold. Nerve morphology, mechanical sensitivity, and tear breakup time improved during the first 1 to 3 months after surgery, with little change thereafter. Chemical sensitivity was associated with tear secretion (P<0.05). Conclusions. Central corneal mechanical sensitivity is reduced in patients after LASIK, with partial recovery seen 3 months after surgery. A similar recovery trend is seen for nerve morphology.


The article describes the prerequisites for the formation of relationships with mediators and purposes of these relations for the manufacturer, as well as mediators. The importance of creation of distribution channels partnerships for enterprise and peculiarities of interaction between participants is updated.


Since its introduction as a new anti-platelet agent a decade ago, clopidogrel has been shown to be a useful drug in the treatment of non-ST elevation acute coronary syndromes. Its use in such conditions has been advocated by national UK, European and international guidelines issued by a number of professional regulatory authorities. However, in the past few years, new evidence has emerged from a number of clinical trials supporting the expansion of clopidogrel use to include ST elevation myocardial infarction and patients undergoing both urgent and elective percutaneous coronary interventional procedures in the form of an initial loading dose followed by a daily maintenance dose, usually for a period of 12 months. This review paper aims to highlight areas in clinical practice where clopidogrel use does not follow the agreed guidelines. It also compares the published UK, European and international guidelines with the up-to-date evidence that recently became available from clinical trials. The paper also outlines some suggested recommendations to be considered when issuing any new clopidogrel-related guidance documents. KeywordS Clopidogrel, dual anti-platelet therapy, ischaemic heart disease, percutaneous coronary intervention declArAtion of intereStS No conflict of interests declared. Paper 1TO Mudawi, 2L Morrison 1Specialist Registrar in Cardiology; 2Consultant Cardiologist, Cardio-Thoracic Centre, Liverpool, UK Published online May 2008 Correspondence to TO Mudawi, Cardio-Thoracic Centre, Thomas Drive, Liverpool L14 3PE, UK tel. +44 (0)151 228 1616 fax. +44 (0)151 60


In the early 1730s, Leonhard Euler (1707–1783) astonished his contemporaries by solving one of the most burning mathematical puzzles of his era: to find the exact sum of the infinite series 11 + 1 4 + 1 9 + 1 16 + 1 25 + · · · , whose terms are the reciprocal squares of the natural numbers. This dramatic success began his rise to dominance over much of eighteenth-century mathematics. In the process of solving this then famous problem, Euler invented a formula that simultaneously completed another great quest: the two-thousand-year search for closed expressions for sums of numerical powers. We shall see how Euler's success with both these problems created a bridge connecting continuous and discrete summations. Sums for geometric series, such as 11 + 1 2 + 1 4 + 1 8 + · · · = 2, had been known since antiquity. But mathematicians of the late seventeenth century were captivated by the computation of the sum of a series with a completely different type of pattern to its terms, one that was far from geometric. In the late 1660s and early 1670s, Isaac Newton (1642–1727) and James Gregory (1638–1675) each deduced the power series for the arctangent, arctan t = t− t3 3 + t 5 5 − · · · , which produces, when evaluated at t = 1, the sum π4 for the alternating series of reciprocal odd numbers 1− 13 + 15 − 17 + 19 − · · · [133, pp. 492–494], [135, pp. 436–439]. And in 1674, Gottfried Wilhelm Leibniz (1646– 1716), one of the creators of the differential and integral calculus, used his new calculus of infinitesimal differentials and their summation (what we now call integration) to obtain the same value, π4 , for this sum by analyzing the quadrature, i.e., the area, of a quarter of a unit circle [133, pp. 524–527]. Leibniz and the Bernoulli brothers Jakob (1654–1705) and Johann (1667– 1748), from Basel, were tantalized by this utterly unexpected connection


The requirements at individual level to manage mass casualty situation are team organisation, first aid training at college levels, setting priorities, and proper training to work in disaster situation where facilities will be limited. Proper liaison, efficient communication and expedient coordination of all resources are required at organizational levels to effectively manage Mass casualty situations and plans of medical and health sector needs to be associated with disaster response services.


On the basis of seismic test of 9 latticed panels, a low cyclic reverse loading and pseudo-dynamic test of a six-story 1/2 scale model house was carried out. By means of hammerblow and pulse methods, different dynamic characteristics of the model structure on the stage of zero load, balance load and different failure states were acquired. The crack and its mechanism of the model house under earthquake were analyzed, and the cracking load, limited load and the correspondent deformation were measured, from which the seismic bearing capacity of the prototype was evaluated.


In norms of international criminal law,the principle of superior responsibility is an important principle derived from individual criminal responsibility.It is a criminal responsible type in that military commanders and other senior officers should be held by this principle on the ground that their subordinates implementing specific international crimes.From the practical value point of view,the principle of superior responsibility entrusts certain obligations with military commanders and other senior officers,so that international criminal principle will cover nonfeasance of superiors,which is significant for deterring international crimes and conducting international criminal trials.After a series of international criminal justice practices,concepts and principles of superior responsibility has gradually formed,and well-established in international common law and major international legal documents.


This paper describes the design of a geothermal air conditioning system aiming at to contribute to reduction of the energy consumption in a residence or small business. The conditioning system here described takes advantage of the surface geothermal heat as a universal, silent, odourless, renewable and clean source of thermal energy. The whole set is based on a liquid refrigerant circulating inside the buried hose hose with the help of a small water pump, so that the soil can balance different temperatures both for summer and winter. The heat is then exchanged with the ground mass, that is, if the temperature inside the building is less or higher than the underground that heat or cool can be exchanged between them without any heat pump arrangements. The prototype system is working at the moment with a geothermal heat exchanger in conjunction with an electronic control to maximize the action of the water pump and the ventilation system.


Rating: Mature Archive Warning: Graphic Depictions Of Violence Category: M/M Fandom: Teen Wolf (TV) Relationship: Peter Hale/Stiles Stilinski Character: Stiles Stilinski, Peter Hale, Sheriff Stilinski, Laura Hale, Scott McCall, Talia Hale, Derek Hale, Cora Hale, Allison Argent Additional Tags: Sheriff Stilinski's Name is John, Alive Hale Family, Hurt/Comfort, Hurt Stiles, Past Torture, Suicidal Thoughts, Panic Attacks, Post-Traumatic Stress Disorder PTSD, Threats of Violence, Angst with a Happy Ending Collections: lacyjae's Fave Zombiewolf Moments, BestOfTheBestFanfics, Favorite Fics Stats: Published: 2016-08-11 Completed: 2016-08-28 Chapters: 22/22 Words: 56525


We built and measured radio-frequency (RF) loss tangent, tan δ, evaluation structures using float-zone quality silicon-on-insulator (SOI) wafers with 5 μm thick device layers. Superconducting Nb components were fabricated on both sides of the SOI Si device layer. Our main goals were to develop a robust fabrication for using crystalline Si (c-Si) dielectric layers with superconducting Nb components in a wafer bonding process and to confirm that tan δ with c-Si dielectric layers was reduced at RF frequencies compared to devices fabricated with amorphous dielectrics, such as SiO2 and SixNy, where tan δ ∼ 10-3. Our primary test structure used a Nb coplanar waveguide (CPW) readout structure capacitively coupled to LC resonators, where the capacitors were defined as parallel-plate capacitors on both sides of a c-Si device layer using a wafer bonding process with benzocyclobutene (BCB) wafer bonding adhesive. Our control experiment, to determine the intrinsic tan δ in the SOI device layer without wafer bonding, also used Nb CPW readout coupled to LC resonators; however, the parallel-plate capacitors were fabricated on both sides of the Si device layer using a deep reactive ion etch (DRIE) to access the c-Si underside through the buried oxide and handle Si layers in the SOI wafers. We found that our wafer bonded devices demonstrated F· δ = (8 ± 2) × 10-5, where F is the filling fraction of two-level states (TLS). For the control experiment, F· δ = (2.0 ± 0.6) × 10-5, and we discuss what may be degrading the performance in the wafer bonded devices as compared to the control devices.


We calculate the geometric phase for an atomic qubit coupled to a zero-temperature bosonic reservoir with a Lorentzian spectral density. The geometric phase is obtained without tracing out the degrees of freedom of the reservoir. It is shown that the phase accumulated by the total system is purely geometric and exhibits an oscillation behaviour in both the Markovian and non-Markovian regimes.


This paper presents a convergence proof of CFO on the stability theory of discrete-time-linear system. It reveals the necessary convergent conditions of CFO. Stability condition limits the eigenvalues of motion equations inside the unit cycle in complex plane, and a corresponding convergence criterion was deduced related to the probes' parameters. According to above criterion, a qualitative parameter analysis and a general strategy of selecting parameters of CFO is presented. Finally, a simple numerical experiment approved such strategy above completely.


Damage to bridges has been observed during many recent earthquakes despite the fact that the structure was designed according to model codes. Pier foundations can be made robust by using pile groups and an efficient pile cap. However, in that case the relatively weak components are the abutments, which act as retaining walls during a significant seismic event. Previous studies have shown that there have been several incidents of damage to abutments and shear keys due to pounding. This paper studies the performance of an existing multi-span curved bridge supported on rigidly capped vertical pile groups which pass through a deep layer of soft clay. Soil-structure interaction (SSI) between the pile group and soil is idealized as linear springs in two perpendicular horizontal directions. At the expansion joints and abutments, steel shear walls are provided to improve the performance and concrete shear keys are utilized to restrain the lateral movement of the bridge girders and bridge deck during large earthquakes. The earthquake response of the bridge with SSI is obtained under unidirectional earthquake excitations at various angles. A seismic retrofit scheme is implemented at the abutments, using buckling restrained braces (BRB) at each girder which are parallel to the deck length, to prevent pounding damage. BRBs are idealized using bilinear plastic link elements with a backbone curve adopted from experimental data. Time history analyses are performed for historical earthquakes. It is observed that the soft soil surrounding the piles has a significant effect on the dynamic response of the bridge; in addition, the bearing displacements are underestimated if SSI is ignored. Non-linear analysis shows that pounding damage to the abutments and the deck can be prevented by using a combination of properly designed BRBs. Incremental dynamic analysis with scaled ground motions shows that the relative displacement between the deck and the abutment is reduced up to 50% after implementing a retrofit with BRBs. Concrete shear keys are also protected against damage due to the reduced lateral displacement of the deck.


This paper discusses design philosophies and technology needs for the power management and distribution (PMAD) portion of a lunar base power system. A process is described whereby mission planners may proceed from a knowledge of the PMAD functions and mission performance requirements to a definition of design options and technology needs. Current research efforts at the NASA Lewis Research Center to meet the PMAD system needs for a lunar base are described. Based on the requirements, the lunar base PMAD is seen as best being accomplished by a utility like system, although with some additional demands including autonomous operation and scheduling and accurate, predictive modeling during the design process.


Abstract BACKGROUND AND AIMS Chronic kidney disease (CKD) patients, especially those on renal replacement therapy, have a higher risk of infection and worse clinical outcomes after coronavirus disease 2019 (COVID-19) than the general population. Thus, this population must be promptly immunized against COVID-19. We aimed to assess the humoral response after two doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccine in peritoneal dialysis (PD) patients. We also aimed to identify potential factors associated with vaccine response and the prevalence of COVID-19 in a PD unit. METHOD We conducted a single-center, retrospective study to evaluate the immunogenicity in terms of antibody response after COVID-19 vaccination. Three types of vaccine [BNT162b2 messenger RNA vaccine (Pfizer-BioNTech), messenger RNA-1273 (Moderna) and ChadOx1 nCoV-19/AZD1222 (AstraZeneca)] were administered in the PD unit. The detection of anti-spike IgG antibodies (with a cutoff of 0.8 U/mL) was done at least after 21 days of the two vaccine doses. We also evaluated the presence of COVID-19 infections, hospital admissions (including in intensive care unit) and deaths. RESULTS This study enrolled 70 prevalent patients. We excluded patients with only one vaccine dose (n = 4), those who did not consent to the collection (n = 5) or were vaccinated before starting PD (n = 11). Among the 50 patients included, the mean age was 59 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$ \pm $\end{document} 15 years, 60% were male and the dialysis vintage was 22.1 (IQR 6–34.3) months. Six (12%) patients were receiving immunosuppressive therapy and 16 (32%) had diabetes. The mean interval between administration of the second vaccine dose and antibodies evaluation was 7.2 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$ \pm $\end{document} 0.7 months. Overall, after two doses, there was a significant increase in antibody level, with median of 1495 (IQR 37.8–546.8) U/mL. Only two (4%) patients did not increase their antibody level (remained seronegative). History of immunosuppressive therapy was associated with no response after two doses (91.7% versus 8.3%, P = 0.012). There were two COVID-19 infections after the complete vaccination, with mild symptoms (one with hospital admission). Furthermore, there were no intensive care unit admissions or deaths. CONCLUSION We found that immunization against COVID-19 was effective in generating an overall humoral response and in preventing severe disease in CKD patients on PD, which emphasizes the importance of the vaccination against COVID-19 in this population. These results also suggest the impact of the immunosuppressive therapy on vaccine response in PD patients.


It is shown that an analogy exists between the neutron flux as predicted by single-group neutron diffusion theory and the axial component of the electric field intensity in a field excited as a plane transverse-magnetic wave in a cylindrical cavity. The buckling of a homogeneous bare core could be determined using simple microwave devices to an accuracy on the same order as the uncertainty of the cavity dimensions. Experimental techniques are described for measuring control rod worth for fully extended cylindrical control rods of arbitrary cross section. Illustrative solutions are shown for circular, hexagonal, square, cruciform, "Y," and sheet cross sections located at the center and at radial positions in a circular core. A method is described for predicting the flux distribution in the core region and experimental examples are shown. (auth)


The high cultural status and centrality of calligraphy in the Japanese visual-art tradition, as in that of East Asia generally, is perhaps the most obvious of the defining features of that tradition. Calligraphy is not the 'seed art' of Japan and East Asia because of any religious taboo against depicting the human image, but rather because of the high aesthetic and spiritual value attached to the calligraphic art itself. There was a moment in the history of the separate careers of Japanese and Western expressionism when the two traditions made tentative contacts with each other and a genuine and lasting meeting of minds and even of artistic practice seemed a real possibility. Certainly, in terms of viewer response, some cognizance of the millennia-long calligraphic tradition and its centrality in Japanese culture is necessary for a full understanding of the impact of zen-ei sho in postwar Japan. Keywords: calligraphic art; east Asia; Japanese culture; Japanese expressionism; Japanese visual-art tradition; western expressionism; zen-ei sho


OF DISSERTATION JOINT DECISION-MAKING IN MARRIED COUPLES AFFECTED BY APHASIA Background: Aphasia is an acquired language disorder, usually due to stroke, that affects the social functioning and the quality of life of the person with aphasia as well as the quality of life of his or her family and caregivers. Traditional aphasia therapy has tended to focus on decontextualized tasks and discrete elements of language functioning. The Life Participation Approach to Aphasia (LPAA) focuses on the collaborative nature of communication and addresses communication within personally relevant contexts. Joint decision-making is one type of social interaction that occurs frequently between married couples and has received considerable attention in the literature. To date, no study has investigated how married couples affected by aphasia collaboratively make decisions. Aim: The present study aims to provide foundational information on joint decision-making by married couples affected by aphasia. Methods and Procedures: Fourteen married couples in which one of the spouses had aphasia volunteered to participate in the study. A variety of assessment measures were administered to the participants with aphasia to characterize their speech and language deficits and all participants were administered a non-verbal reasoning test and a marital quality scale. The primary task of interest in this study involved a joint decisionmaking activity in which spouses were read two hypothetical 'survival-type' scenarios and were given a list of items for each scenario. The spouses were instructed to decide on six items and then rank their selected items in order of importance in terms of their value in helping them survive the scenarios. Participants' interactions were audioand videorecorded, and their verbal communication transcribed verbatim. The participants' communicative interactions were coded for speech functions and analyzed by comparing differences in communication behaviors between the spouses with and without aphasia. Results: Findings showed that participants with and without aphasia utilized a variety of speech functions but that the participants with aphasia made far fewer attempts to persuade their spouse to agree with them and that the spouses without aphasia tended to dominate the interaction, resulting in an imbalance of power in the decision-making process. Despite the differences in communication behaviors, both groups of spouses were supportive of the ideas suggested by their significant other and conflicts were typically resolved quickly. Conclusion: Findings from this study revealed potential discrepancies in the balance of power between the spouses with and without aphasia in decision-making communication. Suggestions are provided for tailoring interventions and guiding future research in joint decision-making in couples affected by aphasia.


ABSTRACT When the towboat Girard Lewis lost power on the Arkansas River Navigation System, it drifted into a railroad bridge near Pine Bluff, Arkansas. Upon impact, it lost the two oil barges it was pushing; one barge floated downstream and was impaled by icebreakers on U.S. Army Corps of Engineers Lock and Dam No. 4. The resulting damage to the barge caused a major discharge (8,000 barrels) of No. 6 fuel oil, which affected industrial and recreational uses of the river and threatened sensitive environmental areas, including the White River National Wildlife Refuge. The discharger accepted responsibility for salvage of the damaged barge but not for containment and cleanup of the spilled oil. Consequently, the U.S. Environmental Protection Agency initiated a federal removal project using the oil pollution response fund authorized under the Clean Water Act. A coordinated effort among at least seven federal and state agency representatives on site was carried out over 25 days. Special problems were encounter...


This paper introduces a new dual-mode dielectric patch resonator (DPR), which consists of a thin square dielectric patch with high permittivity and a low-permittivity substrate with bottom ground plane. A pair of TM11 degenerate modes can act as the dominate mode by fusing the dielectric patch and the substrate with the ground plane, whose resonant frequency is derived by using the combination of mixed magnetic wall method and mirror theory. It can be found that the constructed dual-mode DPR owns both merits of the planar transmission line and the dielectric resonator at the same time, i.e., low-profile configuration and high unloaded quality factor (Qu). Based on the proposed dual-mode DPR, a single-ended bandpass filter (BPF) and a differential BPF is designed respectively. Good agreement can be observed between their respective simulated and measured results. Both of them showcase several advantages such as low passband loss, low profile, and compact size.


Operating a robot in the micro/nano-world presents challenges not found in the macro-world. Due to the small dimensions, the operator has no direct access to the objects and must assemble them by teleoperation. To allow a good manipulability, we propose a mixed teleoperation system which is composed of both direct and task-oriented teleoperation modes. The operator is provided with a set of visualization and manipulation tools on a workstation. This paper presents the micro-robot system, discusses some important issues in micro-teleoperation and finally presents some micro-manipulation tasks performed with the system.


In recent years, there has been carried out an extensive research on the possibilities of the use of glass in combination with other materials as safe surface and members structures. Timber-glass composite I-beams are one of the ideas of built up members with glass as a structural material. Such beams contain glass web and timber flanges. The idea of these beams appeared in 2000. The first serious research and analysis of these beams, in which the glass web is connected to the wooden flanges. The paper focuses on the study of previous studies of timber-glass I-beams. Joints of timber and glass together, differences in stiffness of both materials and capacity in uncracked stage and postcritical load capacity were the main points of the paper. As a summary, the idea of further research on these elements was outlined, resulting from the unrecognized problem of thermal loads, long-term loads and dynamic loads acting on these elements.


The class of quantum operations known as local operations and classical communication (LOCC) induces a partial ordering on quantum states. We present the results of systematic numerical computations related to the volume (with respect to the unitarily invariant measure) of the set of LOCC-convertible bipartite pure states, where the ordering is characterised by an algebraic relation known as majorization. The numerical results, which exploit a tridiagonal model of random matrices, provide quantitative evidence that the proportion of LOCC-convertible pairs vanishes in the limit of large dimensions, and therefore support a previous conjecture by Nielsen. In particular, we show that the problem is equivalent to the persistence of a non-Markovian stochastic process and the proportion of LOCC-convertible pairs decays algebraically with a nontrivial persistence exponent. We extend this analysis by investigating the distribution of the maximal success probability of LOCC-conversions. We show a dichotomy in behaviour between balanced and unbalanced bipartitions. In the latter case the asymptotics is somehow surprising: in the limit of large dimensions, for the overwhelming majority of pairs of states a perfect LOCC-conversion is not possible; nevertheless, for most states there exist local strategies that succeed in achieving the conversion with a probability arbitrarily close to one. We present strong evidence of a universal scaling limit for the maximal probability of successful LOCC-conversions and we suggest a connection with the typical fluctuations of the smallest eigenvalue of Wishart random matrices.


Pulsed laser deposition(PLD) is a modern method to prepare many kinds of functional materials.The process can be divided into three stages:laser ablation,plasma expansion,and film growth.There are many complex phenomena in these processes,and we shall briefly describe the current research on the mechanism of PLD.The dynamics of the basic physical processes of the three stages will be explored in detail,with particular emphasis on the work in China.We introduce various models such as the self-consistent unified model covering all three PLD processes,the shock wave plasma expansion model,a new plasma evolution dynamics model based on local energy-momentum conservation,the ablative heat conduction model which includes terms taking into account the heat source,evaporation,plasma shielding,and dynamic physical parameters,and a unified thermal model suitable for higher energy fields which takes into account electron-electron collisions and the density of states effect,and can explain thermophysical effects with pulse widths ranging from nanoseconds to femtoseconds.


OBJECTIVE
To compare the antiemetic effects of metoclopramide and hyoscine in patients after laparoscopic cholecystectomy.

DESIGN
Prospective, randomised trial.

SETTING
University hospital, Sweden.

SUBJECTS
100 consecutive patients median age 49 years (range 21-79) of whom 9 were withdrawn after randomisation.

INTERVENTIONS
Patients were randomised to receive either four doses of metoclopramide 10 mg intravenously starting at the induction of anaesthesia (n = 44), or hyoscine transdermally through a patch placed behind the ear at 0600 h on the day of operation (n = 47).

MAIN OUTCOME MEASURES
The incidence of nausea and vomiting.

RESULTS
Metoclopramide was significantly more effective at preventing both nausea and vomiting (20/44 (45%) compared with 32/47 (68%), p < 0.05, and 10/44 (23%) compared with 21/47 (45%), p < 0.05). Women were significantly more likely to become nauseated than men (46/66 (70%) compared with 5/25 (20%), p < 0.001). Two patients in the metoclopramide group developed dizziness, and one patient in the hyoscine group had a disturbance of vision. About 20% in each group required additional antiemetic treatment. The median hospital stay in both groups for patients who did not develop complications was 2 days.

CONCLUSION
There was a high incidence of nausea and vomiting after laparoscopic cholecystectomy even after treatment with metoclopramide. Further measures are indicated, particularly for women.


This thesis is concerned with measuring and predicting the performance and effectiveness of a data fusion process. Its central proposition is that information entropy may be used to quantify concisely the effectiveness of the process. The personal and original contribution to that subject which is contained in this thesis is summarised as follows: The mixture of performance behaviours that occur in a data fusion system are described and modelled as the states of an ergodic Markov process. An new analytic approach to combining the entropy of discrete and continuous information is defined. A new simple and accurate model of data association performance is proposed. A new model is proposed for the propagation of information entropy in an minimum mean square combination of track estimates. A new model is proposed for the propagation of the information entropy of object classification belief as new observations are incorporated in a recursive Bayesian classifier. A new model to quantify the information entropy of the penalty of ignorance is proposed. New formulations of the steady state solution of the matrix Riccati equation to model tracker performance are proposed.


Training of penitentiary psychologists on the educational program «Psychology of official activity» is conducted in two universities of the Federal penitentiary service (FSIN of Russia). An important component of the practical and scientific activities of the penitentiary psychologist is the development, conduct and analysis of various psychological studies that require a high level of development of the necessary competencies. This article discusses the author's methodology IVDRC (Individual vector of development of research competencies), used in the training of penitentiary psychologists in the study of mathematical methods in psychology. The methodology is based on the continuity and professional orientation of training courses, individual approach, support and control of the stages of study of disciplines, the use of information technologies, own methodological materials and manuals. The developed technique is a generalization of long-term experience of teaching mathematical disciplines in departmental higher education institution. The technique of IVDRC has been successfully used for several years at the psychological faculty of the Vologda Institute of Law and Economics of the Federal Penal Service of Russia. To date, more than 150 cadets have been trained using the technology of IVDRC. The article analyzes some results and efficiency of its application using statistical methods .


The present invention in the supporting foil and the display panel to improve the packing structure for a simple, and reduced manufacturing costs, provide a packaging for the transportation costs for inexpensive thin display apparatus to transport the semi-finished product in the form of thin-film display panel safely. The invention in constituting the packaging for packing a thin display panel (M), a dog the package stand 4 is twos first thin-film display panels (M) edge of the receiving edge receiving portion thin display panel (11) which (M a ) it is set up and the panel and stillness that one side wall (the drive circuit (40 of the thin-film display panels (M) to 15)) of the unit 12 receiving part (15a) is installed, the panel fixing part 12 that is teller and edge fixing member 10, which is, two of the twos 1, install long in the width direction so as to secure the upper and lower portions of each of the thin film display panels (M) fixed to the edge of the holding member 10, the constant on the lower the spacing projections 22 and gripping grooves 24 are further includes a width direction holding member 20 to be arranged alternately. Thin display panel, module, for packing


The process of parental care can be complex, and it is rarely exhibited by reptiles. How predators influence the timing of parental care is still ambiguous in terrestrial vertebrates. In this study, we demonstrate that female skinks of Mabuya longicaudata adjusted to an experimental manipulation of interspecific intruders which were placed into skink nests. When the intrusion frequency of the reptile-egg eating snake, Oligodon formosanus, increased, the time spent on maternal care by M. longicaudata was significantly extended. In contrast, female M. longicaudata recognized two sympatric lizards (Sphenomorphus incognitus and Japalura swinhonis) which do not prey upon eggs or adults of M. longicaudata and did not attack those species; consequently, the time spent on egg-guarding did not significantly differ from the control treatment with intrusion by S. incognitus or J. swinhonis. Mabuya longicaudata also recognized the predatory snake, Elaphe carinata, and when that species entered a skink nest, the skink escaped and never returned. These results emphasize that the time spent on parental care is probably influenced by predators, and the duration of this behavior is dependent on the maternal defensive capability. As egg guarding is the most basic and primitive form of parental care, the current study provides evidence possibly leading to insights into the origin of parental care from reptiles to birds and mammals.


Objective To investigate the mental health status of undergraduate nurses in order to give them psychological guidance for a new job. Methods Self-rating scales(SCL-90) were sent to 52 nursing undergraduates and compared with nationwide youth nom. Results The score was higher in the students than that of the nom group in seven factors in SCL-90(t=2.24-6.50;P0.05,0.01).The main psychological problems in students during their clinical training were depression,somatization,compulsion,anxiety and sensitivity in interpersonal relationship. Conclusion The mental health stutas is relatively weak in undergraduate nurses at clinical rotation,which is related to the transition from relatively-simple school environment to complicated society,and also due to facing employment pressure.


Few reforms have captured the imagination and excitement that surrounds the notion of coordinated services for children. Numerous attempts are under way nationwide to change a fragmented system of services for children into more effective sets of partnerships. However, service organizations do not make partnerships easily, due to a number of issues ranging from autonomy to funding concerns. This article examines some basic assumptions and questions surrounding knowledge dissemination and utilization in the service coordination arena, seeking to draw facilitation strategies from a series of ongoing projects in Chicago, Houston, Los Angeles, and Minneapolis. The authors also draw heavily on a body of emerging theory and inquiry known as "the new institutionalism."


Vehicle Classification has been a well-researched topic in the recent past. However, advances in the field have not been corroborated with deployment in Intelligent Traffic Management, due to non-availability of surveillance quality visual data of vehicles in urban traffic junctions. In this paper, we present a dataset aimed at exploring Vehicle Classification and related problems in dense, urban traffic scenarios. We present our on-going effort of collecting a large scale, surveillance quality, dataset of vehicles seen mostly on Indian roads. The dataset is an extensive collection of vehicles under different poses, scales and illumination conditions in addition to a smaller set of Near Infrared spectrum images for night time and low light traffic surveillance. We will make the dataset available for further research in this area. We propose and evaluate few baseline algorithms for the task of vehicle classification on this dataset. We also discuss challenges and potential applications of the data.


Objective To study the distributed features of intraepithelial lymphocyte(IEL) and lamina propria lymphocyte(LPL) of small intestine(duodenum,jejunum,ileum) and large intestine(sigmoid colon) in rat.Methods Basilar membrane of bowel villi was marked by immunohistochemistry double staining,differentiate epithelia and lamina propria,and the amount of IEL and LPL were counted.Results The amount of IEL in various parts(duodenum,jejunum,ileum and sigmoid colon) of rat intestinal tract decreased in turn.On the contrary,the amount of LPL increased in turn.The difference among T cell subsets were obvious(All stated differences achieved statistical significance at P ≤0.05).Conclusion The method of double staining to account the number of IEL and LPL is very accurate,and IEL and LPL in different part of the intestine tract may play different biological roles in immune response of mucosa.


In recent years, the spotlight circular synthetic aperture (CSAR) has attracted an increasing interest in moving target tracking because of its long synthetic aperture time. However, due to its long synthetic aperture time and circular track, parameter estimation is more difficult than that in LSAR. In this paper, the moving target's range history for spotlight CSAR is derived, and a sub-aperture-based parameter estimation method is proposed, where Doppler parameters and interferometric phase information by along track interferometry (ATI) are performed. Simulated and measured data results verify the correctness of the theoretical analysis and the validity of the proposed method.


The paper has do simply comment about the causes of the endangered Hezhe language at our predecessors.And put forward some new study view which endangered language causes,May be provided for the reference afterwards related to subject about endangered language.


Objective To study the effect of safflower injection in the treatment of patients with coronary heart disease. Methods 122 patients were randomly divided into two groups, namely the control and the experimental group, each group with 61 cases. The control group was treated with compound danshen injection treatment, and the experimental group was taken with safflower injection therapy. The clinical efficacy, blood dynamic index and the occurrence of adverse reactions were compared between the two groups. Results The effective rate in the experiment group was 96.72%, higher than 72.13% in the control group. After treatment, the whole blood, high shear viscosity, shear whole blood viscosity, whole blood viscosity, plasma viscosity of the experimental group were lower than those of the control group, and the difference was statistically significant(P 0.05). No obvious adverse reactions were found in both groups. Conclusions Safflower injection in the treatment of coronary heart disease achieves good clinical result. It can effectively reduce the hemodynamic parameters in patients with coronary heart disease, and improve the patient's quality of life.


An experiment entitled "Evaluation of CropSyst model for yield and water productivity of chickpea" was conducted on farmers field during rabi2012-13 at village Mainawali in Hanumangarh district of Rajasthan. The soils of the area are alluvial and calcareous in nature formed under arid and semi arid climate. The soils of site are brown to grayish brown and dark gray in colour, besides being calcareous and slightly alkaline in reaction having 67.7, 11.1 and 21.0 % of sand, clay and silt, respectively in 0-15 cm soil depth with pH 8.09 and low soil organic matter content. The simulated and observed green area index differs with field measurements at all stages. The simulate yield of chickpea were closer to the observed yield. The total water applied in chickpea was 415 mm out of this 356.5 mm consumed in ET. Thus, ET constituted 86% of total water applied and deep drainage constituted 12% and rest 2% stored as residual soil moisture.


In the small catchment "Obere Brachtpe" (2,5 km ), Sauerland, central west Germany, runoff generation processes have been investigated since 2000 with a hydrometric, hydrochemical and soil physical approach. The experimental investigations have been focused on the analysis of the influence of relief, soil and soil moisture dynamics on the discharge processes at the plot and hillslope scale. Therefore four soil hydrology measurement locations and fourteen piezometers are installed in the catchment "Obere Brachtpe". The measurement locations are arranged in a gently convergent slope ranging from the upper slope to the riparian zone. They are equipped with several tensiometers installed in different depths (20 to 200 cm). The water suction is registered automatically every 10 minutes. Moreover the precipitation and the runoff are measured at the catchment outlet in a 10 minrespectively 15 min-interval. The groundwater gauges are fitted with pressure heads and dataloggers (10 min-interval) and arranged in two sections vertical to the valley. The first section is installed in a gently convergent slope, the second at the foodslope of a divergent slope.


Characteristics of soil-applied herbicides are discussed, including site of uptake by weeds, solubility, adsorption, persistence, leaching potential, photodecomposition, and volatility.


Summary form only given. The switching of the core of a vortex in a thin film by a perpendicular field has been predicted, on topological grounds, to occur through the creation and displacement of a Bloch point (BP). With the recently obtained MFM pictures of vortex cores, experimental observation of this process becomes possible. The authors present numerical 3-D micromagnetics simulations, using the public code OOMMF. The material parameters were permalloy-like, damping parameter /spl alpha/=0.5, thickness=50 nm. The samples were disks, diameter 100-400 nm; the mesh size was always below the exchange length /spl Lambda/=5 nm.


Niosomes are a bilayered non-toxic, non-immunogenic nanoparticular delivery system; it is being used for drug delivery. Owing to its cost-effectiveness and easy manufacturing processing, niosomes are gaining popularity as a coveted drug carrier. Main constituents of a niosomes are cholesterol and a non-ionic surfactant, although several additives like charged molecule (Solulan C24) can be added to modify the surface charge of the particle and enhance its stability. There are various methods of manufacturing niosomes like hand shaking method, micro fluidization, sonication, bubble method to name a few. The fact that niosomes are amphiphillic molecules make them a versatile drug carrier as they can entrap both hydrophilic and lipophillic drugs. Applications of niosomes in the pharmaceutical industry therapeutic use, some of the most important ones being as cosmoceuticals, etc. In this review an effort has been made to document the key concepts relating to niosomes and the advances that have been made in terms of research in the field of niosomal drug delivery.
Keywords: niosomes, nanoparticles, cholesterol, carrier, non-ionic, vesicles.


Argument and Change in World Politics: Ethics, Decolonization, and Humanitarian Intervention. By Neta C Crawford. Cambridge: Cambridge University Press, 2002. 466 pp., $85.00 cloth (ISBN 0-521-80244-X), $30.00 paper (ISBN 0-521-00279-6).

The end of the Cold War witnessed an impressive growth in the study of the impact of norms on international and domestic politics. The subject matter of the new work typically involved issues that had previously been the provenance of normative philosophers and international lawyers. Issues connected to just war theory and international humanitarian law, such as inhumane weapons and military intervention, received considerable attention (Price 1997; Tannenwald 1999). The broad category of human rights (women's suffrage, antislavery movements, torture, democratization) also figured prominently (Nadelmann 1990; Ron 1997; Keck and Sikkink 1998; Kaufmann and Pape 1999; Risse, Ropp, and Sikkink 1999). The focus on such issues in the new scholarship often seemed driven by ethical concerns, but the methods for studying them were fairly conventional and empirical rather than normative. The main innovations came in the theoretical realm, as students of normative change found traditional realist and institutionalist approaches (usually linked under the rubric "rationalist" or "materialist") lacking in explanatory power. Thus, much of the new work on norms developed constructivist theoretical frameworks and pitted them against rationalist accounts, sometimes finding that a combination of approaches worked best (Katzenstein 1996; Checkel 1997; Thomas 2001).

In parallel with the mainly North American constructivist study of norms, a group of German scholars was drawing upon the work of political theorist Jurgen Habermas to produce valuable insights into the effect of "communicative action" on international politics. A number of intrepid bridge-builders have sought to integrate the Habermasian work on argument and persuasion with mainstream constructivist and rationalist approaches, often with promising results (Risse 2000; Checkel 2001; Schimmelfennig 2001). Now, with the publication of Neta Crawford's Argument and Change in World Politics , we have a work that makes a major theoretical advance in …


Objective:To evaluate the effect of echocardiography in the diagnosis of coronary lesions in Kawasaki disease. Methods:Forty-one cases of Kawasaki disease underwent echocardiography. Results:Twenty-two cases showed coronary arterial lesions, with the incidence of 53.6% (22/41). Nineteen cases showed coronary dilatation and 3 showed coronary aneurysm. Conclusion:Measurement of coronary artery in Kawasaki disease by echocardiography plays an important role in detecting coronary artery dilatation and coronary aneurrysm formation.


ABSTRACT Artificial neural networks (ANNs) and Gb*-based regression models were used for the prediction of the dynamic modulus (|E*|) of South Carolina's hot mix asphalt mixtures (HMAs) the majority of which contained recycled asphalt pavement (RAP). Models' training and testing were done using a database that contained 1656 |E*| values from 93 HMA mixtures. Gb*-based models included the Hirsch, revised Hirsch, Bari-Witczak, revised Bari-Witczak, Al-Khateeb 1, Al-Khateeb 2, NCHRP 1-40D, and the simplified global models. The results showed that Gb*-based regression models had a significant bias in prediction; Coupling VMA and Gb* had the most influence on |E*|; four-layer ANNs generally had a better performance than three-layer ANNs on using Hirsch model's related inputs; ANN 3-15-15-1 and ANN 8-15-15-1 (developed with similar input variables as the Hirsch and Witczak regression models respectively) showed very high performance of R 2 > 0.994 on testing. Therefore, ANNs could be considered to capture the influence of the binders' rheological properties, mixture's volumetric properties, and RAP on |E*| of HMA mixtures far better than regression-based models.


Anthracene derivatives possessing a carbamate group and an ester group at their 9- and 10-positions, respectively, were prepared to furnish pairwise packing of anthracene fluorophores in their crystal structures. They were nonluminescent in ethanol solution and showed AIE (aggregation-induced emission) in aqueous ethanol solution and in solid state. Crystal structure analysis of them showed that the H-bonding networks involved in their crystal structures could be classified into four patterns, H-bonding between the carbamate and the ester carbonyl (motif A), H-bonding between the carbamate and the ester oxygen atom (motif B), H-bonded cyclic dimer of carbamate moieties (motif C), and H-bonded chain among carbamate moieties (motif D). Compounds with pairwisely packed anthracene fluorophores showed dimer emission with the longer fluorescence wavelength than others without the pair formation. Fluorescence maximum wavelengths and lifetimes become longer proportional to the degree of overlapping of two facing ...


Described is a vehicle key (5) for wireless communication with a vehicle (1). Said vehicle key (5) comprises a radio transmitter (7) for transmitting radio signals to the vehicle (1). In order to be able to locate the vehicle (1) within a close range, the vehicle key (5) further comprises a radio receiver (6) and/or an acoustic receiver (6), bidirectional communication with a transceiver (2) of the vehicle (1) being enabled by means of the radio receiver (6) and/or the acoustic receiver (6) and the radio transmitter (5). A corresponding method for locating the vehicle (1) with the help of the vehicle key (5) is also described.


One hundred and sixty isolates of ectomycorrhizal agarics, boletes, and related gasteromycetes were examined for 25 morphological and biochemical characters. A wide range of analytical methods are available with which to obtain efficient summaries of the patterns of variation present in data such as these. Agglomerative clustering of 156 isolates and 18 characters for which no data were missing resulted in partitions of the sample corresponding to recognizable taxonomic and ecological groupings. Key characters useful for delimiting these groups are highlighted by means of divisive clustering and classification trees. For example, boletes (Boletinus, Suillus, Xerocomus) and related gasteromycetous allies (Pisolithus, Rhizopogon, Scleroderma) are distinguished by the production of pigment on media containing high levels of glucose. Numerical taxonomic analyses of cultural characters thus can be useful for examining taxonomic relationships, as in the way in which these characters support not only the close relationship between boletes and some gasteromycetes but also the generic circumscriptions of genera such as Laccaria and Lactarius. However, the taxonomic level at which cultural characters prove most effective must be evaluated carefully, in view of the possibility that, in response to selection, cultural characters have evolved in parallel in separate clades. Thus, ecological as well as taxonomic groups were also recognized. Species of both Hebeloma and Laccaria failed to produce pigment, tolerated low temperatures, and metabolized urea. This suggests that great care must be taken in using cultural characters in phylogenetic studies.


Objective To assess the value of apparent diffusion coefficients(ADC)and regional cerebral blood volume(rCBV)in diagnosis of benign and malignant cerebral gliomas and in grading of the gliomas.Methods Nine patients of low-grade(Ⅰ-Ⅱ)gliomas and 13 patients of high-grade(Ⅲ-Ⅳ)gliomas,underwent conventional MR imaging,diffusion and perfusion weighted imaging with Siemens Avanto 1.5T MR unit.ADC value and rCBV ratio were recorded,and their correlation was analyzed.Results The mean value of the ADC was(12.73±1.40)×10-4 mm2/s in the low-grade gliomas and(9.09±1.85)×10-4 mm2/s in the high-grade gliomas.The value of the rCBV ratio was 3.60±1.09 in the low-grade and 7.92±2.40 in the high-grade gliomas.There was significant difference between the low-grade gliomas and the high-grade gliomas.There was significant correlation between ADC and rCBV ratio(r=-0.53,P0.01).Conclusion ADC value and rCBV ratio can help to distinguish the benign and malignant cerebral gliomas,playing a very important role in grading of the gliomas.


In this paper, the non-autonomous dynamical behavior of weakly damped wave equation with a sup-cubic nonlinearity is considered in locally uniform spaces. We first prove the global well-posedness of the Shatah-Struwe solutions, then establish the existence of the \begin{document}$ \big(H_{lu}^{1}(\mathbb{R}^{3})\times L_{lu}^{2}(\mathbb{R}^{3}),H_{\rho}^{1}(\mathbb{R}^{3})\times L_{\rho}^{2}(\mathbb{R}^{3})\big) $\end{document} -pullback attractor for the Shatah-Struwe solutions process of this equation. The results are based on the recent extension of Strichartz estimates for the bounded domains.


Relationships between the various factors involved in the manufacture of needlepunched geotextiles, their basic dimensional properties and performance characteristics were developed. Multivariate regression analyses were utilized to formulate empirical models in order to predict the performance characteristics from the basic fabric elements. The main variables employed in this mathematical modelling study were punch density (PD), depth of needle penetration (NP), web area density (WAD), fabric area density (FAD), fabric thickness (FBT), fabric bulk density (FBD), puncture resistance (CBR), tensile strength in machine direction (TMD) and tensile strength in cross machine direction (TXMD). Statistical analyses of the breaking extension ranges in the machine and cross machine directions were also performed. The empirical relationships developed showed that it is possible to predict the performance of the needlepunched geotextiles accurately on the basis of their fundamental properties, obtained under a given set of fibre, machine and fabric parameters. These mathematical models have been validated for a very wide range of manufacturing parameters and performance characteristics of needlepunched geotextiles. For the covering abstract see ITRD E117244.


Recent reports have shown that in the UK there has been a decrease in interest towards pursuing a surgical career, whereas early exposure to surgery may increase interest. We aimed to assess the effect of a 1‐day medical school surgical conference in encouraging attendees to pursue a surgical career.


The clinical application of GlucoWatch used in 32 Chinese diabetic patients was evaluated to determine its value in following blood glucose trends and track patterns and to know the compliance of patient. The results confirmed the accuracy of GlucoWatch and showed that it could follow blood glucose trends and track patterns. The skin irritation was mild and most subjects thought that blood glucose monitoring by GlucoWatch could reduce the pain caused by traditional methods.


The competitive scenario requires organizational strategies increasingly elaborated, creating the need of companies to structure their management models in order to absorb these conflicts generated by competition. The manufacturing area is financially affecting deeply the company's results, thus process improvement comes as the organization's survival guideline, and the rationalization of waste without the need for high investments, shown a great competitive alternative. The application of Kaizen event seeks to measure the benefits generated by the implementation of the philosophy of lean manufacturing, working setup aspects of machinery, the manufacturing process flow, reduced delivery lead-time and inventory process. The Kaizen Blitz was applied in a production cell of stamping and spirt processes. The obtained major improvements have been the reduction of machine setup time, reducing lead-time of item processing, the material flow within the production cell, and creating conditions for a more flexible management of the production schedule.


Fluorescence sensitization of a 2,2′-([1,1′-biphenyl]–4,4′-diyldi-2,1-ethenediyl)-bis-benzenesulfonic acid disodium salt (Stilbene 3) solution in ethanol (EtOH) due to the presence in aqueous solution of ammonia is reported here. In this study sensitization of the dye solution due to the presence of ammonia was observed. It was also found that the observed sensitization is dynamic in nature. Sensitization of the fluorescence of the indicator also has full reversibility. An optical sensor for the detection of ammonia could thus be constructed using these properties of the dye and the sensitizer.


The question of what necessitated the formulation of the principles on which environmental law is structured is of antiquity. However, this question is more an issue today as it was in the 1970s when the world first collectively woke up to the importance of the environment and its relevance vis-a-vis the continued survival of humanity. Academic discourse about the environment and environmental laws today typically associates the latter with an ever increasing and dynamic array of principles. Environmental law was developed in response to the public perception that human health and the environment were inadequately protected. This dissertation posits that which it is believed amounts to a discourse of the theoretical basis and relevance of environmental law. To achieve this, the paper is divided into six parts: this being the first; Part II is dedicated to an expose on the nature - and not a definition - of environment law. It puts across the thesis that environmental law is an admixture of thoughts sourced from different and divergent fields of endeavour. Part III has as its scope the need for environmental law. Part IV attempts a chronicle of the emergency of environmental law and also makes it known that environmental law is a modern day construct and Part V focuses on the theoretical basis of environmental law with specific attention to the principles of sustainable development and its subset - intergenerational equity. Part VI is the climax of the discourse and it captures the closing thoughts as it relates to the theme of this paper.


One hundred and six isolates of the Dutch elm disease (DED) fungi Ophiostoma ulmi and Ophiostoma novo-ulmi were collected from elm trees with symptoms in 15 regions of Spain. Isolates were compared with eight reference strains belonging to O. ulmi and the two subspecies of O. novo-ulmi. The purpose of this study was to assign Spanish isolates to species and subspecies of the DED fungi and to analyse the genetic variability within the Spanish populations of these pathogens. Isolates were examined for their growth rates, colony morphologies and fertility responses and by using random amplified polymorphic DNA (RAPD) markers. Six isolates were identified as O. ulmi, 16 as O. novo-ulmi ssp. novo-ulmi and 78 as O. novo-ulmi ssp. americana. Nei's and Shannon's diversity indices and the upgma dendrogram from RAPD profiles indicated a high level of variation among isolates, probably reflecting post-epidemic status of DED in Spain. Although most isolates were separated into three major clusters representing the three taxa of DED fungi in the RAPD analysis, two isolates from central Spain clustered between O. novo-ulmi ssp. americana and O. novo-ulmi ssp. novo-ulmi, and four isolates from Mallorca clustered between O. ulmi and the group representing O. novo-ulmi ssp. novo-ulmi. Mating tests conducted with these isolates revealed a variety of fertility responses. The novel combinations between molecular profile and fertility reaction suggest that three isolates from Mallorca may be interspecific hybrids of the DED fungi.


Abstract The evaluation of product styling design is transformed into a complex nonlinear solution problem by symmetry analysis in this paper. The equilibrium matrix decomposition evaluation system calculates the stored matrix singular values in product styling design and proves that symmetry can be obtained from the stress matrix row vector. The regression algorithm is used to process multiple industrial product design objectives, and each design element in product styling is coded to obtain the fitness evaluation of individual industrial products. It is found that the satisfaction score in product styling design is 97.4, the weight index of logo novelty element is up to 7, and the regression coefficient of plane shape is 0.269, to improve the scientific and feasibility of aesthetic evaluation of industrial product styling design.


It was hypothesized that in selecting a dissonance-reduction technique people will search for a solution which is a stable one. Given a choice among modes of dissonance reduction, the individual will search both for a mode which is not challenged by present events and information, and for a mode which is unlikely to come under reality attack in the future. To test this hypothesis, nursery-school children made a decision between 2 toys. One could reduce postdecision dissonance by increasing the attractiveness of the chosen alternative, or decreasing the attractiveness of the rejected alternative, or both. In the experiment, some children expected to hear, in subsequent wks., objective information about whichever toy they chose; others expected to hear objective information about the rejected toy. It was expected that children would reduce their postdecision dissonance by distorting their liking for whichever alternative (the chosen toy or the rejected toy) could not be contradicted by future objective information, rather than by distorting both alternatives. This hypothesis was strongly confirmed.


Statement. The MLL-MLLT4 (former MLL-AF6) fusion gene (FG) is relatively rare genetic abnormality, predominantly found in AML. It averages 3–5% among other MLL rearrangements. Here we present data of MRD monitoring in 2 patients with AML carrying an MLL-MLLT4 rearrangement by 2 approaches: using

1. FG transcript at RNA/cDNA level in comparison with

2. FG at genomic DNA level.

Materials and methods. Patients (pts) were diagnosed according French-American-Britain (FAB) classification. Initial diagnostics included cytomorphology, immunophenotyping of blast cells, cytogenetics, FISH and reverse transcriptase PCR (RT-PCR). RT-PCR products were directly sequenced afterwards. In both cases identification of genomic chromosomal breakpoint sequences within MLL and MLLT4 genes was done by long-distance inverse PCR (LDI-PCR). MRD quantification in genomic DNA was performed using patient-specific primers and probes by real-time quantitative PCR (RQ-PCR). 500 ng of DNA was used per reaction. Standard curve was received by serial 10-fold dilutions of pts' DNA into the DNA isolated from pooled lymphocytes of ten healthy donors. b-actin was used as DNA quality and quantity control. Detection of FG transcript kinetics during treatment was performed by RQ-PCR according to "Europe Against Cancer" recommendations for normalization by using control gene ABL (Gabert J. et al Leukemia, 2003, 17) and for using 10-fold dilutions of plasmids carrying MLL-MLLT4 fragment as source of standard curve. MRD value for cDNA targets were estimated as previously described (Beillard E. et al Leukemia, 2003, 17). Each sample was run in triplicates. According to the treatment design, time-points for MRD estimation were scheduled before each block of treatment. Totally 5 samples were evaluated in each patient (initial and 4 follow-ups). FLT3 -ITD status was estimated at the time of diagnosis. Informed consent was obtained in both cases.

Patients' characteristics, treatment and clinical outcome

| | Case # 1 | Case #2 |
|:-------------------------------------------------------------------:| ----------------------------------------------------------------------------------------- | ------------------------------- |
| Age | 58 | 13 |
| Sex | Male | Male |
| Initial WBC*106/ml | 5.5 | 94.9 |
| Immunophenotype | CD34+CD117+HLA-DR+ CD11c+CD13+CD33+CD65+ | CD34+CD117+CD13+ CD33+CD45+MPO+ |
| Cytogenetics | 46, XY, del(5)(q?), der(5)t(5;6;11) (q22;q15q27;q23), der(6)t(5;6) (q22;q15), del der(11) | 46, XY, t(6;11)(q27;q23) |
| FISH with LSI MLL | MLL deletion | MLL split |
| RT-PCR | MLL-MLLT4 positive | MLL-MLLT4 positive |
| MLL-MLLT4 FG transcript | exon 9-exon 2 | exon 9-exon 2 |
| Localization of genomic chromosomal breakpoint within MLL and MLLT4 | intron 9-intron 1 | intron 9-intron 1 |
| FLT3-ITD | Negative | Negative |
| Induction treatment | 7+3 | AIE |
| Consolidation therapy | 2× HAM 2× HDAC | 1× HAM 1× FLAG 1× HAE |
| Maintenance | − | + |
| Duration of therapy, months | 8 | 7 |
| Achievement of CR | + | + |
| OS, months | 8 | 7 |
| EFS, months | 6 | 5 |
| Current status | Alive in CR | Alive in CR |

Results . Despite of achievement of CR, MLL-MLLT4 FG transcripts were detected in every sample tested after induction and consolidation chemotherapy by RQ-PCR. MRD value in case #1 in cDNA was fluctuated significantly within 2 log. Although in case #2 there was successive reduction from 260% at the beginning of treatment till 0.7% before maintenance therapy (after HAE block). Limited dilution series of a MLL-MLLT4-positive RNA into RNA of ten healthy donors showed a sensitivity limitation of 1E–05. For quantification of genomic chromosomal breakpoint sequences b-actin was amplified in each well. Deviation between Ct values of b-actin in different wells did not exceed ±2.0. In case # 1 the standard curve of the RQ-PCR assay for MLL-MLLT4 FG had slope of −3.19. Correlation coefficient was 0.987. Quantitative range of this assay was 1E–04 and sensitivity 1E–5. It was also observed a considerable variation of MRD levels in genomic DNA during treatment, like it was observed in MRD monitoring by FG transcripts. Fluctuations run up to 2.5 log. In case #2 the standard curve of the RQ-PCR assay for MLL-MLLT4 had a slope of −3.63 with correlation coefficient 0.992. Quantitative range of this assay was reached 1E–04 with sensitivity 1E–05. MRD level in this patient constantly decreased.

Conclusions . The same tendency has been shown in each patient: fluctuations of MRD levels (2.5 log in case #1) and successive reduction (case #2). Results received at RNA/cDNA level and in genomic DNA cannot substitute each other, but they can be used as additives. It has been demonstrated that quantification of MLL-MLLT4 FG in genomic DNA is precise and suitable for MRD monitoring.


Fingermillet fodder (local variety) was harvested at 75 of sowing between 50% flowering and dough stage an fed to 5 crossbred (Holstein Fresian X jersey Tharparkar) bullocks (5 years, 551 kg.). Average DM and CP contents were 21.6. and 9.4% in the rodder. DMI/100 kg body weight was 1.62 kg/d. The digestibility coefficients or UM, OM, CP and CF were 67.4, 69.1, 59.1, and 70.9%, respec ve y. The higher OMD was mainly associated with higher digestible NDF (43 %). The DCP and TDN values were 5.5 and 61.6 kg/100 kg UM On this basis it appears to be a potential forage crop for feeding to livestock.


The results of large-scale simulations investigating the dynamics of magnetization reversal in arrays of single-domain nanomagnets after a rapid reversal of the applied field at nonzero temperature are presented. The numerical micromagnetic approach uses the Landau–Lifshitz–Gilbert equation including contributions from thermal fluctuations and long-range dipole–dipole demagnetizing effects implemented using a fast-multipole expansion. The individual model nanomagnets are 9 nm×9 nm×150 nm iron pillars similar to those fabricated on a surface with scanning tunneling microscope assisted chemical vapor deposition [S. Wirth et al., J. Appl. Phys. 85, 5249 (1999)]. Nanomagnets oriented perpendicular to the surface and spaced 300 nm apart in linear arrays are considered. The applied field is always oriented perpendicular to the surface. When the magnitude of the applied field is less than the coercive value, about 2000 Oe for an individual nanomagnet, magnetization reversal in the nanomagnets can only occur by t...


This paper presents the numerical and experimental analysis of the seakeeping performances of a survey vessel operating in the Caspian Sea. For the numerical analysis we have developed our own code, based on a linear hydro-dynamic strip theory formulation. The irregular waves are modelled by short-term power density spectra JONSWAP, for the spectral parameters significant wave height and peak period corresponding to the Caspian Sea scattering diagram. The experimental study is developed at the towing tank from Naval Architecture Faculty of Galati, using a semi-captive scaled model 1:16 of the survey vessel, made of fibre glass and wood, being recorded the heave, pitch, roll motions and wave elongation. The experimental tests are carried out for two speeds and several significant heading cases: head, follow and beam regular waves. This study delivers the prediction of the survey vessel seakeeping capabilities and the validation of the numerical response amplitude operators by experiment.


This paper develops an endogenous directed technical change model that is consistent with the data on the distribution of firms and production across high- and low-tech sectors, and its relationship to economic growth, in a number of developed countries. We argue that scale effects at the industry level and the cross-country differences in the relative supply of skills induce the observed pattern in the industrial structure. We show, through calibration, that the predicted values for the number of firms, production, firm size and the economic growth rate closely match the relationship with the relative supply of skills observed in the data.