Carbon fibers and composites derived from mesophase pitch exhibit ultrahigh stiffness and thermal conductivity due to a high degree of graphitic content, which is generated by the liquid crystalline state of the precursor and the molecular orientation that is developed during melt processing steps. To understand the flow and its effect on microstructure, this paper presents an integrated experimental and modeling approach for a synthetic discotic mesophase pitch (AR-HP). Careful control of shear rate and strain was exercised throughout the rheological studies. Wide-angle x-ray diffraction studies were conducted on carefully solidified rheological specimens to obtain azimuthal profiles for layer plane orientation. Cross-polarized microscopy was conducted in the reflected mode using a first-order red plate to examine the orientation in three orthogonal planes. Under the influence of steady shear, the microstructure of mesophase pitch became flow-aligned, which is similar to the fibrous structure reported in...


Addressable arrays that use switches to isolate the devices being tested are limited in size and utility by the parasitic leakage caused by those switches. A new biasing technique that removes the drain-source bias from these switches has been studied to address this problem. Simulations performed in a 90 nm low-power technology predicted more than a two-decade drop in parasitic leakage of the array. Experiment data performed on a 90 nm technology confirmed this improvement.


This paper examines the conflicting values inherent in the discharge planning process. A framework for analysis of an ethical dilemma is proposed and applied to a case situation that is common for hospital social workers. Although the framework does not resolve the dilemma, it does provide the social worker with some criteria for explicating the values inherent in the discharge planning process.


In this paper, we present new fixed-circle theorems for self-mappings on an S-metric space using some Wardowski type contractions, ψ-contractive, and weakly ψ-contractive self-mappings. The common property in all of the obtained theorems for Wardowski type contractions is that the self-mapping fixes both the circle and the disc with the center x0 and the radius r.


This ambitious book is the first to provide a detailed insight into the politics and practices of internal school exclusion, highlighted through the experiences of the young people attending internal behaviour support units.


IT is remarkable how interest in this important subject appears to be confined, if we may judge by the literature, to England and America, and it must be admitted that the bulk of the contributions to our knowledge concerning surgical shock come from the latter country. In England, the work of Crile, confirmed and expounded by Mummery, has almost become the settled article of our surgical creed, in spite of the powerful criticisms of Malcolm, based on clinical experience. The fundamentally important researches of Yandell Henderson on acapnia and shock have not received adequate attention. The principal theories held with regard to the essential nature of shock are the following :I. The Crile-Mummery theory, that shock is due to exhaustion of the vasomotor centres in the medulla and cord. 2. The Yandell Hendersoa theory, that shock is due to acapnia, i.e., reduction of carbon dioxide in the blood in consequence of the excessive breathing reflexly induced by painful stimuli. 3. The Boise theory, that shock is due to cardiac spasm. 4. The Meltzer theory, that the injury leads to inhibition of the functions of all the organs, beginning with the less vital, and spreading to the more vital. In addition to the formal theories set forth by the above writers, we have the following observations to take into account : the contraction of the arteries so much insisted on by Malcolm in England and by Seelig and Lyon in America ; the concentration of the blood described by Sherrington, by Roy and Cobbett, and other observers ; the disappearance of the chromaffine matter in the cells of the medulla of the suprarenal glands, to which attention has been called by Bainbridge and Parkinson ; and the changes in the nerve cells of the brain described by Dolley and Crile. Having now collected the various opinions and researches which claim a hearing, we proceed to examine some of them in more detail.


Sport is considered a social and cultural phenomenon with great ability to mobilize the masses in today´s society. However, a deep critical analysis whether high-performance sport, entertainment sport and everything that surrounds this environment is positive for the formation of children and adolescents in society, should be conducted through Physical Education.
It is a world in which the result is the most important thing. It is only the winning that counts, and often at any price.
For this reason, an intervention to manage competition in a school environment is suggested on this proposal. Standing in this type of field, a U- turn on competition regarding high performance sport must be taken. Broadly speaking, this proposal includes all the students considering their singularities. Some will have good physical and motor skills for sports but not others, that is why all the students will be taken into account for the development of the activities and especially for assessment, so that everyone gets recognition and success.
The priority of this proposal is the transmission of values through the development of different sports games (football, handball, basketball), which do not take into consideration the technical and tactical aspects of each student. In order to promote an educational competition, different attitudes and positive values will be considered.
Therefore, the most important part of the proposal can be the evaluation. Through this part, the different aspects assessed in the students will be seen, and consequently the approach given to the competition in terms of making it educational and possible to develop in an educational establishment.
The proposed intervention will be framed in the Maristas school of Pamplona and will be aimed at students in the 4th of Secondary Education.


The title compound, C 32 H 42 N 2 O 4 Si, is a key intermediate in the stereoselective synthesis of α,β-diaminoaldehydes, α,β-diaminoacids and chiral 1,2-diamines. The X-ray structure determination shows that the nitrone [C-CH=N + (O - )-C] system is planar with torsion angles of 175 (H1-C1-N1-O1) and 175.0° (C2-C1-N1-C5).


In the paper,under the condition of that a singular system is admissible,stable controls for a bilinear singular system are designed by using two kinds of Lyapunov function respectively,and the two above control display different forms.At the same time,the control restrained by upper and lower bound is examined.Choosing a appropriate control a bilinear singular closed loop system can be globally asymptotically stable.For a single-input bilinear singular system,a stable region of closed loop system around the origin is approached. Finally,an example is given to illustrate the validity of the obtained results.


Report of the Taskforce on Employment Opportunities (Chairman: Montek S. Ahluwalia) Report of the Steering Committee on Labour and Employment for the 10th Five Year Plan (2002-2007) Report of the Special Group on Targeting 10 Million Employment Opportunities per Year (Chairman S.P. Gupta).


Editor We are grateful to Dr Yan and his colleagues for their letter in response to our article. We stated that the hepatic venous system of the right posterior section was classified into 8 types, and an inverse relationship was observed between the diameter of the right hepatic vein (RHV) and inferior right hepatic vein (IRHVs). The data presented by Yan et al. are interesting and we also think that the length of RHV plays an important role in dividing the anterior and posterior segment. On the other hand, it is clear that the objectivity of the parameter is extremely important. Although Yan et al. have mentioned that the length of the hepatic vein is of more significance than the diameter, we still insist that the diameter could be a more valuable parameter than its length. This is because we believe an accurate definition of the length of the hepatic vein may be difficult because most hepatic veins form curves and these curves influence its measurement. Furthermore, the accuracy of the imaging systems easily affects measurements of the hepatic vein. In addition, previous reports have predominantly applied the diameter of the vein in relation to the anatomy of hepatic veins1-3. With regard to Type 3, the frequency is extremely low at approximately 3%. The SRHV of Type 3 has an average diameter of 3⋅8 mm, which is relatively thick, and we believe that it is not an underestimation that the SRHV dominates drainage of segment 7. In the present case, it is appropriate to approximately evaluate the areas predominantly drained because there is a limit to the resolution of CT examination. In addition, we believe that future studies are necessary to accurately reveal the venous anatomy of the posterior section. Akira Watanabe , Norifumi Harimoto , Kimitaka Kogure and Ken Shirabe Department of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan


Variable speed drives are growing and varying. Drives expanse depend on progress in different part of science like power system, microelectronic, control methods, and so on. With the use of space vector technique to electrical drive control the, efficiency and reliability of drives increase and volume, weight and cost of them decrease. Due to the improved operating characteristics they give to the equipment control, Escalators pumps, elevators and conveyor belts all operate more effectively if they are soft started. In turn, the SVPWM method and FLC method reduces maintenance, conserves energy and plays a significant part in improving plant performance and operating costs. This paper presents a novel design of a Sugeno fuzzy logic control scheme for controlling some of the parameters, such as starting current, speed, torque, flux, voltage, etc. of the induction motor. Induction motors are characterized by highly non-linear, complex and time-varying dynamics and inaccessibility of some of the states and outputs for measurements, and hence it can be considered as a challenging engineering problem. The development of advanced control techniques has partially solved induction motor's speed control problems; because they are sensitive to drive parameter variations and the performance may deteriorate if conventional controllers are used. Fuzzy logic based controllers are considered as potential candidates for such an application. Further, the Sugeno control strategy coupled with rule based approach in a fuzzy system when employed to the induction motor yields excellent results compared to the other methods as this becomes a hybrid & integrated method of approach. Such a mixed implementation leads to a more effective control design with improved system performance, cost-effectiveness, efficiency, dynamism, & reliability. Its performance is thereby evaluated for the speed control. The simulation results presented in this paper show the effectiveness of the method developed & have got a wide number of advantages in the industrial sector & can be converted into a real time application using some interfacing cards. KeywordsPI Controller Fuzzy Logic Controller, Simulink Matlab, Induction Motor, IGBT Inverter, Vector Control Technique, Closed Loop, Parameter, Robustness.


This study is an extension of a project published by Mortis (1956). The "Ways to Live Questionnaire" and the "Sixteen Personality Factors Questionnaire, Form A" were administered to a random sample of 201 undergraduate university male students. The hypothesis, that students who like a certain philosophy towards life will have personality traits different from those of students who do not like it, was supported. However, the statistical results as well as the interpretation of the relationships in this study differ from those reported by Morris.


Ataxia telangiectasia and Rad3 related (ATR) and ataxia telangiectasia mutated (ATM) protein kinases play key roles in the DNA damage response (DDR) by responding to replication stress and double-strand DNA breaks respectively to pause the cell cycle and promote DNA repair. ATR kinase inhibition in cancer cells disrupts cell cycle control and causes unrepaired DNA lesions and cytotoxicity. Accordingly, several ATR inhibitors (ATRi) are in clinical development as monotherapies and in combination with DNA damaging chemotherapies and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that while treatment of cancer cells with an ATRi inhibits the ATR pathway, it simultaneously activates the ATM signaling pathway as shown by increased levels of p-ATM, p-CHK2, p-KAP1 and p-p53. In p53 wild-type cancer cells, ATR inhibition causes an ATM-mediated G1 cell cycle arrest which diminishes the DNA lesions and cytotoxic effects of ATR inhibition. Combination of an ATRi with a selective ATM inhibitor (ATMi) synergistically potentiated efficacy in cancer cells in vitro and increased efficacy in vivo at doses that did not show overt toxicities. In a panel of patient-derived xenograft (PDX) models of triple-negative breast cancer treated with an ATRi/ATMi combination, substantial improvement in efficacy was observed. Thus, activation of the ATM pathway by an ATRi acts as a compensatory resistance pathway for ATR inhibition. These results suggest a novel and efficacious combination approach for cancer therapy by dual inhibition of these two key DDR kinases.
 Citation Format: Audrey Turchick, Astrid Zimmermann, Li-Ya Chiu, Heike Dahmen, Brian Elenbaas, Frank T. Zenke, Andree Blaukat, Lyubomir T. Vassilev. Inhibition of ATM-dependent checkpoint control and DNA double-strand break repair enhances the efficacy of ATR inhibitors. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6212.


Synthesis of β-D-galactopyranosyl disaccharides takes place in growing cultures of Sporobolomycessingularis containing lactose and a sugar acceptor. The products of galactosyl transfer using various acceptors arise mainly from substitution of secondary rather than primary hydroxyl groups. The minimal structural requirement for reaction with the acceptor appears to be a hydroxyl vicinal to the substituted hydroxyl group. A mechanism that accounts for the formation of secondary disaccharides is postulated.The organism also contains a β-glucosidase which transfers O-β-D-glucopyranosyl groups from cellobiose to sugar acceptors. The positions of the glycosidic linkages in the disaccharide products are identical with those formed in the corresponding galactosyl transfer reaction.


AIMS
Raloxifene, a selective estrogen receptor (ER) modulator, has been reported to exert the tumor-suppressive effects in both ER-positive and ER-negative cancer cells; however, the mechanisms underlying its ER-independent anti-cancer effects are poorly understood. The NLRP3 inflammasome, a critical component of the innate immune system, has recently received growing attention owing to its multifaceted roles in various aspects of cancer development. The present study aimed to examine the involvement of NLRP3 inflammasomes in the anti-breast cancer effects of raloxifene and its underlying mechanisms.

RESULTS
Raloxifene significantly inhibited activation of NLRP3 inflammasomes in various breast cancer cell lines. Importantly, forced expression of a gain-of-function variant of NLRP3 rescued breast cancer cells from growth arrest by raloxifene, suggesting that suppression of NLRP3 inflammasomes activation mediates the raloxifene-induced inhibition of breast cancer growth. Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner. Furthermore, blockage of AhR signaling or inhibition of mitophagy abolished the tumor-suppressive effect of raloxifene in a human breast tumor xenograft model.

INNOVATION
We elucidate a novel molecular mechanism underlying the breast tumor suppressing effect of raloxifene.

CONCLUSIONS
The results observed in this study suggest that modulation of NLRP3 inflammasomes activation is a critical event in inhibition of breast tumor growth by raloxifene.


An investigation to study the morphological characteristics of soils by examining the profiles and physical and chemical properties of soil by analysing the profile samples was undertaken in the Oilseed Experimental Station, Tindivanam. The soils were classi- fied taxonomically. This study will be useful to lay out the various research experi ments based on the soil characteristics.


Onion (Allium cepa L.) bulbs produced in the Pacific Northwest of the United States in 2014 and 2015 had unusually high incidence of internal decay. This decay was not detectable externally, leading to marketing problems when bulbs were packed and shipped to markets. The onion growing seasons in 2014 and 2015 were unusually hot, suggesting a connection of heat stress to bulb internal decay. Field studies to investigate the effect of temperature on onion bulb internal decay and yield were conducted in 2016–18 with drip-irrigated onions at the Oregon State University, Malheur Experiment Station located in eastern Oregon. Two long-day onion cultivars were submitted to four cultural practice variations to affect soil and bulb temperatures: bare soil check, supplemental heat using electric heat cables, white kaolinite clay application to the bulb sides and soil surface, and wheat (Triticum aestivum L.) straw mulch. The treatments established significant midafternoon average bulb and soil surface temperature gradients in the following order of increasing temperature: straw mulch, kaolinite, check, and supplemental heat. Averaged over years and cultivars, straw-mulched onions had the highest yield of bulbs larger than 102 mm diameter. Averaged over years and cultivars, onions receiving supplemental heat had the lowest total and marketable yield with no difference among the other treatments. Straw mulched onions had higher total and marketable yield than the bare soil check treatment in 2017, the hottest year. Averaged over the 3 years and two cultivars, marketable yield and yield of bulbs larger than 102 mm diameter decreased with increasing midafternoon bulb temperatures. Kaolinite application did not increase bulb yield nor bulb size compared with the bare soil check. The incidence of internal bulb decay was low all 3 years. In 2017, onions receiving supplemental heat had the highest internal decay and the straw-mulched onions had among the lowest internal decay. There was little difference in the measured soil moisture among treatments. Straw mulching may attenuate the negative effects of excessive heat on yield and bulb internal quality for long day onion production.


Equations for vector addition, vector cross products, and vector differentiation are represented in signal-flow-graph form, and are used to obtain signal flow graphs of the (tensor) equations of rotating rigid bodies. These signal flow graphs, in turn, are then applied to the analysis of several simple gyroscopic devices.


The article discusses the teachers' adaptability of higher vocational school based on the educational reform of higher vocational school.On the one hand,the author analyzes the concepts of adaptive ability,and proposes the elements of adaptive ability which teachers should have;on the other hand,strategic countermeasures are proposed from the development point of organization and self-organizing system,based on the two-way penetration into higher vocational school teachers' adaptive ability.


AGEENKO, Maria. Company Business Plan, Opening a Subway restaurant in Belarus. [Bachelor dissertation] Institute of Hospitality Management in Prague. Prague: 2017. Total number of pages 57. Subway IP Inc. is the largest in the world fast-food chain (due to the quantity if locations) with submarine sandwiches, salads and pizzas presenting in 112 countries as franchisees. Currently Belarus is one of few countries in Europe that hasn't got any Subway restaurants, yet other similar business such as McDonalds, Burger King and KFC are already presented. Even though nowadays Belarus faced some economic difficulties, this country has perspectives for investors. Franchising became popular business model among fast-food restaurants worldwide, however each country has its own specificity for operating this kind of company. It can be governmental regulations regarding this way of doing business, cultural aspects, economic or competitive situation and some other factors that should be taken into consideration when opening a new market. The following bachelor thesis answer a question 'Does it worth to open a Subway restaurant in Belarus' and analyses Belarusian market in the context of doing business, examines the main challenges and existing fast-food competitors' business models. Also, the paper observes existing governmental regulations in Belarus concerning doing business as franchising company. The aim of the thesis is to create a business plan for opening a Subway restaurant. As a methodology survey research, in-depth interviews and case study research were used. Preparation, presentation and ability to defend successful business plan indicates the prospect of a potential franchisee and increases the chances of being accepted into the network. Results of this paper reflect key aspects for investors: the amount of necessary investments, marketing and management plan, HR plan, Belarusian market prospective including risk analysis and the rationale for location point.


A simple method for improving surface-enhanced Raman scattering (SERS) performance of aligned silver nanorod (Ag NR) array was investigated. This method was to construct a kind of hybrid substrate by grafting Au@Ag core–shell nanoparticles (NPs) into Ag NR array using poly(2-vinylphridine) (P2VPy) as a bridging agent. The hybrid substrate yielded excellent SERS performance as its detection limit improved from 10−6 M to 10−8 M using trans-1,2-bis(4-pyridyl)ethylene (BPE) as probe molecule, which was increased by two orders of magnitude compared with Ag NR array substrate. The significant improvement of SERS performance of Ag NR arrays was attributed to the addition of Au@Ag core–shell NPs. As a result of surface plasmon resonance generated by the interaction of electromagnetic (EM) (IAEM) filed between NP and NR structures, increasing hotspots were found at the connections of NPs and NRs, the gaps of adjacent rods, and the gaps of two particles consequently. These results were validated by the finite difference time domain (FDTD) calculation. Besides, hybrid substrate shows good performance in stability and reproducibility. The proposed method was simple and robust, which promoted SERS performance of Ag NR array effectively, showing great potential in the application of SERS substrate fabrication and SERS-based bio-chemical sensing.


Muscle hypoxia and fatigue are related to the generation of lactic acid in hypoxic regions of the muscle which may limit exercise capability. While generally thought that such regions are homogeneously extended over the muscle mass and activated by exercise, our recent results with a very simple muscle function imager show, to the contrary, that exercise limitation may involve specific rather than generalized portions of the muscle. Thus a simple, noninvasive optical device which is portable and efficacious, could be used to increase understanding of the contribution of particular muscles during different exercises. This could open new possibilities for the evaluation of muscle performance and fatigue of normal and pathological states.


The result of the experiment showed that the activity of DNase and RNase grew higher with the content of DNA and RNA grew lower under both single shade and double shade.The activity of DNase and RNase grew much higher under double shade than the activity of DNase and RNase under single shade,so was the content of DNA and RNA.This suggested that the activity of DNase and RNase plays an important part in causing the growing of the content of DNA and RNA.


I am indebted to the authorities of the Otago Museum, Dunedin, New Zealand, for permission to publish a column-krater which they have recently acquired. The vase is unbroken, but the main scene is badly pitted; the reverse is practically undamaged. The glaze is a good lustrous black except for an area below one handle which has fired red and dark brown. There are lotus-buds on the neck above the main scene only, and rays round the base between two bands of red. The pictures are unframed, but a third red line runs round the vase to serve as a ground line for the figures.


A procedure is described which makes it possible to analyze and interpret the results of calculations performed by means of the LCAO–SCF molecular orbital method including configuration interaction (the Pariser–Parr–Pople method) in the language of the isoconjugate‐hydrocarbon model, localized‐orbital model, or other appropriate models. A general process is shown for expressing the wavefunctions of any electronic configurations or states based on the SCF orbitals by the corresponding wavefunctions based on "reference" orbitals. Specific formulas are given for expanding the wavefunctions of lower singlet and triplet configurations of the former type in terms of the configuration wavefunctions of the latter type. The π‐electronic states of the phenol molecule are dealt with to illustrate the present analysis.


Cascading Failure has become one of the points of scientific research in complex networks. In this paper, we use the different definition of Load and Capacity in the network, to research the final changing direction of Cascade model with an attack. When the node Capacity is within a specific range, Risk Strength and Elasticity of the link both affected the result of the attack on ER network. Because of the elasticity of link, the degree of Cascading Failure does not increase in pace with attack. The elasticity of the link becomes essential to mitigate the failure under different risks.


Alexander A. Gorbunov - Lecturer, Department of Information Systems and Digital Infrastructure Management, National Research University Higher School of EconomicsAddress: 20, Myasnitskaya Street, Moscow, 101000, Russian FederationE-mail: email@example.com A. Isaev - Professor, Head of Department of Information Systems and Digital Infrastructure Management, National Research University Higher School of EconomicsAddress: 20, Myasnitskaya Street, Moscow, 101000, Russian FederationE-mail: firstname.lastname@example.com F. Morgunov - Associate Professor, Head of Department of Information Systems and Digital Infrastructure Management. National Research University Higher School of EconomicsAddress: 20, Myasnitskaya Street, Moscow, 101000, Russian FederationE-mail: email@example.com In universities and technical colleges with relevant IT qualifications in one semester multiple streams, courses and specializations can use software products for training purposes. IT services of universities should deal with the challenge of creating the infrastructure of educational applications that can support the educational process. We note that the number of specializations which study information technology are growing every year (for example, in HSE there are disciplines-minors, which can enroll students coming from any field). Also in the recent years, online courses have started to become popular. If the load is not planned ahead taking into account future trends, the power of even the most high-tech infrastructure will be insufficient. Calculation of the corresponding load on the infrastructure must be made in the planning process of the disciplines, so that we can reserve appropriate facilities, and thus organize an effective learning process. Software developers use a variety of benchmarking tools that are complex and do not provide the necessary information for the participants of educational process planning. This article discusses the construction of a simulation model that supports the educational process planning. The simulation is carried out using the capabilities of the tool AnyLogic 7. The aim of this work is to develop a simulation model designed to estimate the load on the information system used in the educational process. In addition, besides the description of the model, the article presents the results of calculations used for various options of the information system (private cloud or on a server at the university). The simulation results were confirmed by data obtained during practical classes at the university. This model gives us the opportunity to plan the educational process in order to achieve uniformity of the load on the services. If necessary, the model allows us to make a decision about the location of the educational information system: on servers of the university or in a private cloud.


The present study proposes the evaluation of the impulsive force induced by the snap-through buckling mechanism of closed-elastica in terms of the momentum. A cable-mass system with slackness is developed as a benchmark setup, where the snap-through buckling mechanism imposes the impulsive force on the mass through the wire. The recorded time response of the mass provides the momentum of the snapthrough buckling according to the conservation law. Experiments are carried out with several kinds of mass parameters, and the impulsive force induced by the snap-through buckling is successfully evaluated in the proposed context.


1. A patient with a Vitallium hinged knee prosthesis studied at autopsy forty-two months after implantation was presented.

2. Clinically, the patient had no complications or clinical evidence of tissue reaction while receiving good, pain-free service from the prosthesis.

3. Pathologically, a massive amount of Prussian blue positive staining material was found in the capsule and lining the canals formed by the stems of the prosthesis.

4. Mechanical wear (corrosion) was evident at the areas of contact and on the central axis of the hinge.

5. The importance of mechanical design and composition is seen to be a significant consideration of reconstructive surgery.


This paper analyses the reasons that caused college students' credibility crisis and points out the way to solve this problem.


A PEOPLE is in movement. The Jewish people, wanderers for centuries and scattered all over the earth, are gathering anew on the land of Israel. It would seem that the longing, never lost, for the country of their ancestors is about to be satisfied. It is the culmination of several tentative efforts in recent years to resurrect the ancient kingdom of David. Especially is the development of Zionism associated with the Austrian Jew, Theodore Herzl, who headed the movement thirty years ago. But the realization of the Zionist dream involved so many social, financial, and political problems that its visionary nature was only too apparent. It was scarcely conceivable that Abdul Hamid, Commander of the Faithful, would relinquish Jerusalem with its mosque of Omar, next to Mecca and Medina the most sacred place of the Moslem world; or that the Christian nations would comtemplate with favorable eye a Jewish guard around the Holy Sepulcher. How would the Russian government accept a Jewish triumph in Palestine, reinforcing the power and pride of the Jews that remained on their territory? And how could the Jews of France, Germany, England, and America, sincerely attached to the countries of their adoption, be committed to the reclaiming of a new country?1


There have been growing complaints of women not being part of UN peacekeeping operations despite the fact that women are the most vulnerable in conflict situations. To address the complaints of sidling women from UNPKOs, the United Nations Security Counsel adopted Resolution 1,325 to incorporate gender mainstream in all UNPKOs. This examines the strategies the UN had adopted to address the anomaly.


Creative and critical practices are essential for creating positive impact on health and wellbeing. This issue of R:ADAR provides an introduction to some of the many art, design and architecture projects that are helping to create safer, healthier communities. Our projects investigate how health practices and environments affect people's thoughts, feelings, experiences and behaviours, and ask how things might be done differently. Taking an integrated approach to human health, we work closely with healthcare professionals, governments, technology providers, patients and carers to create better outcomes for individuals, communities and the planet. XYX Lab operates at the intersection of gender, identity, urban space and advocacy. The team of architects, urban designers, and visual communication and digital engagement specialists build equity into urban life by developing and promoting co-design strategies and projects that address the needs of women, LGBTIQ+ people and other minority groups. 'Keep Running', responds to the Australian Centre for Contemporary Art's provocation of Public Space? Keep Running is a series of dynamic graphic interventions across greater Melbourne that provoke dialogue around women and gender-diverse people's right to access public space. Through posters and billboards, Keep Running articulates a call to action for communities to develop an understanding of safety and risk in the city, and creates an opportunity for audiences to consider their own lived experience while developing understanding and empathy. 'RetroFit Kit' demonstrates a pathway for the systematic modification of common Australian housing types to achieve seamless and dignified home environments for people with disability, their families and carers, and future occupants. Working in research-led education units, the project took a typological approach to the problem and focused on common building types across Melbourne. This research generated an exhibition as part of Melbourne Design Week that simulated a home environment at 1:1 scale to demonstrate principles of accessibility through design strategies that enhance the home environment. 'Retrofit Kit' is part of a research collaboration between Monash Architecture and the Australian Human Rights Commission that is making explicit the strategic potential of architectural design for making homes more equitable and accessible to all. Bradley's research interrogates how colonial frameworks of media production perpetuate ongoing trans-generational trauma and oppression. His project examines the potential and limitations of the (re)presentation of Aboriginal people and narratives across the corporate, government and creative practice sectors for improving Aboriginal wellbeing and redressing the oppression of Aboriginal peoples and culture. neurodiverse PhD project pioneers the facilitation of co-designing interior architectural individuals non-verbal the creation of spaces that the individual and preferences her non-verbal of


This article deals with a semantic feature analysis executed in the process of translation of Toba Batak Modalisation into English. The data in this article are all derived from actual daily conversation conducted by the native speaker. The analysis in this research is focused to see the semantic feeatures of modalisation both in Toba Batak language and English, which is based on the modalisation theories used by Saeed (2009), Saragih (2004), and Halliday (1994). Through the analysis, it can be concluded that both Toba Batak language and English have the same sorts of modalisation, but with different realization. Based on its types, modalisation in Toba Batak language are all realized by modal adjuncts, but in English, they can be realized by finite modal operators, modal adjuncts, or both. Based on its value, modalisation has a high, medium and low value in both laguages; and based on its orientation, modalisation can be classified either as subjective or objective, explicit or implicit in both languages. After conducting the analysis on their semantic features it can be concluded that the Toba Batak modalisation can be equivalently translated into English.


T HE ARMISTICE which put an end to the Korean 'police action' was signed in July, 1953. Although some seven years have elapsed since then, little attention has been paid to the language of the American soldier who served during the Korean hostilities. The only study of post-Korean army language is that of Arthur Norman, who has published two articles about the Japanese influence on American speech in Japan.' The present account of the special vocabulary of the American GI in Korea is the product of random notes and remembered occurrences and consequently far from complete; perhaps others who have had experience in that part of the world will also record what they know of 'Korean' slang before this peculiar form of linguistic behavior is forgotten, even by those who once practiced it. The slang of the Korean GI was time-honored army talk with a gilding of Japanese and Korean borrowings. This traditional army slang sometimes suffered a sea change in its transit across the Pacific and acquired new uses in its new environment. In addition, -many of the GI's had had prior service in Japan and had there learned the elements of Bamboo English, a Japanese slang which was intelligible to the Koreans because of the long Japanese occupation of the peninsula. Korean Bamboo English was a form of oral communication; it had no proper written form. Consequently, in recording Korean and Japanese words I have generally used an impressionistic spelling; however, for the former I have occasionally employed the McCune-Reischauer romanization.


De Kadt's response to my article is deserving of comment for two reasons: firstly, as a fraternal and principled critique it seeks to raise our understanding of the role and impact of the managerial innovations of the early 20th century to a new level ; secondly, it brings into particular relief the contrasting visions of the political economist and the historian, thus illuminating two different con-


This paper describes the rationale, approach and some of the key findings of a socio-economic study to support the feasibility study of the proposed Lower Usuthu Basin Smallholder Irrigation Project in Swaziland. Die productive capital stock of the area is limited, and individual wealth is tied up in traditional cattle systems. There is no substantial water storage facility to support large smallholder irrigation developments. Moreover, whiie there are few, examples of successful smallholder irrigation projects in the region, a very successful model is operating in South Africa which facilitates the empowerment of irrigators and supporting private sector services, and in so doing develops the broad rural economy. The paper discusses the benefits which may be gained from adopting this model in Swaziland.


Abstract. The use of cover crops is an increasingly popular sustainable farming practice that provides many benefits to the soil and subsequent cash crops. This research examines the utility of using the image processing model METRIC (Mapping Evapotranspiration at high Resolution with Internalized Calibration) to estimate late season, post-harvest evapotranspiration (ET) rates from fields with a cover crop planted after a cash crop. The objective of this research was to compare actual ET estimates produced by METRIC to ground-based flux point measurements. Remotely sensed ET maps were generated for a 260 km2 area in northeastern South Dakota, USA. Surface energy balance and micrometeorological data were obtained from a Bowen Ratio Energy Balance System (BREBS) located within the image. Nine image dates were used for the growing season, from May through October. Five of those nine were captured during the cover crop season. METRIC was found to successfully differentiate between fields with and without cover crops. In a blind comparison, METRIC compared favorably with the estimated ET rates found using the BREBS, with a difference in total estimated ET for the cover crop season of 7%.


Speech emotion recognition is a challenging yet important speech technology. In this paper, the GMM supervector based SVM is applied to this field with spectral features. A GMM is trained for each emotional utterance, and the corresponding GMM supervector is used as the input feature for SVM. Experimental results on an emotional speech database demonstrate that the GMM supervector based SVM outperforms standard GMM on speech emotion recognition.


Let G be a simple connected graph of order n and size m, vertex degree
 sequence d1 ≥ d2 ≥...≥ dn > 0, and let μ1 ≥ μ 2 ≥ ... ≥ μn-1 > μn = 0
 be the eigenvalues of its Laplacian matrix. Laplacian energy LE,
 Laplacian-energy-like invariant LEL and Kirchhoff index Kf, are graph
 invariants defined in terms of Laplacian eigenvalues. These are,
 respectively, defined as LE(G) = Σn,i=1 |μi-2m/n|, LEL(G) = Σn-1
 i=1 √μi and Kf (G) = n Σn-1,i=1 1/μi. A vertex-degree-based topological
 index referred to as degree deviation is defined as S(G) = Σn,i=1 |di-
 2m/n|. Relations between Kf and LE, Kf and LEL, as well as Kf and S are
 obtained.


In this study, a green and high‐efficiency adsorbent was synthesized. First, magnetic cellulose (Fe3O4/CMC) was prepared by coprecipitation method and then it was compounded with functional graphene oxide (GO) to prepare magnetic cellulose‐supported GO composite (Fe3O4/CMC/GO). As prepared composite was characterized by Fourier transform infrared spectroscopy, X‐ray diffractometer, thermogravimetric, scanning electron microscope, Brunner‐Emmett‐Teller, and vibrating sample magnetometer. The adsorption properties were studied, and the effects of time, temperature, pH, and initial concentration on the adsorption process were investigated. The adsorption mechanism was also discussed. The results showed that the pseudo‐second‐order kinetic model and the Langmuir model were more consistent with the adsorption process of Cu2+ by adsorbents. The whole adsorption process was a spontaneous endothermic process, and the adsorption capacity reached the maximum (199.98 mg·g−1) when the pH was 6 to 7, the initial concentration was 200 mg·L−1, and the temperature was 318 K. The high adsorption rate (86.68%) can still be achieved after 5 cycles of adsorption‐desorption with 1 mol·L−1 dilute hydrochloric acid as eluent.


Purpose: To investigate the role and the place of the surgical management of GISTs. Methods: It was performed a retrospective study involving the patients with GISTs surgically treated in Department of Surgery, University Hospital "Queen Joanna ISUL" between 2005 and 2012. Several parameters were followed up demographic characteristics of the patients, tumor features, clinical manifestation, used methods for diagnosis and treatment and achieved shortand long-term results. The data was investigated with SPSS-19. Results: 39 patients with GISTs were included in the study. Four of them have tumors with extra-gastrointestinal localization (retroperitoneal space in 3 cases and one patient with tumor in the mesentery of the small intestine). The distribution of GISTs in the gastrointestinal tract was established as follows: stomach (21 cases), duodenum (4 cases), small intestine (7 cases) and colon (3 cases). The most common clinical signs were abdominal pain and discomfort, weakness, dyspeptic complaints and gastrointestinal bleeding. 29 patients underwent radical operations with achieved R0 resection. Recurrence was observed in 5 patients. Achieved median, 1-, 3and 5-year survival was respectively 52.91 months, 88%, 81% and 67%. Conclusion: Surgical resection is the only curable method of treatment of patients with GISTs. The achievement of negative resection margins is the most important predictor of survival. B. KORUKOV1, Y. ASENOV1, D. DAMIANOV1, N. PENKOV1, B. VLADIMIROV2, B. GOLEMANOV2, I. TERZIEV3


The purpose of this research was to find out the toxic compound of Curcuma aeruginosa that has influence in the occurence of karyopicnotis, karyorhexis, karyolysis, apoptosis, and PARP-1 expression on hepatocyte cells of male mice as toxic marker compound in five different preparation of Curcuma aeruginosa. The research used 88 male mice Balb C with 2 months old and their weight 25-30 g that were divided into 10 treatment groups (given extracted chloroform, extracted methanol, essential oil, infusion and squeezed curcuma) and 1 control group. Each treatment groups was given 2 doses, 10 mg and 15 mg per 25 g body weight, whereas 1 control group was given CMCNa + aquadest. Treatment was given once a day for 10 days. On day eleventh, mice were sacrified, the liver of mice was taken to histopathological stydy by using HE staining, Apoptaq Detection Kit, and immunofluorescence. Curcuma rhizome compound was analyzed by using GC/MS. Data were analyzed by using MANOVA factorial and be continued by using oneway anova, and PLS to determine what compounds influenced hepatocyte. The results showed that 15 mg of infusion caused the highest karyorhexis with the average of 49.66%. By giving extracted chloroform 15 mg per 25 body weight caused the highest karyolysis and karyopicnotis with the average subsequently 56.31% and 10.61% ( =0.05). By giving extracted chloroform 10 mg per 25 body weight caused the highest apoptosis with the average of 1.49% and 1.33% for the 15 mg dosage ( =0.05). By giving essential oil 15 mg per 25 gram body weight caused the highest expression of PARP-1 with the average of 3369.77 ( =0.05). In conclusion, the 10 mg squeezed curcuma per 25 g body weight was safe to be used in mice.


An alternative set of rules and regulations for the creation and scope of geographic fields in moving image databases for television stations that are either state-run, regional or local is presented. The fields Place of Action, Place Map, Location Map and Geographic Implication are discussed. To this end, the geographic fields used by the state and regional television stations part of the Official Federation of Regional Broadcasters (FORTA) are first analysed explaining their scope as well as noting the differing labels used.


In India, property tax is presently levied on the basis of the rent-based rateable valuation system. Various official Commissions and Committees and professional experts have, over the last four decades, commented upon the inadequacies of this system, which, among other things, are the absence of an open market in land and rental transactions, the non-availablility of professionally trained valuers and the subjective nature of assessments in a corruption-prone administrative environment. As to the direction of future reforms, there have been two schools of thought - one, advocating for amendment of current rent control laws; and the other, favoring a new system of local taxation, delinked both from the capital value and rental value systems which are difficult to administer in India. This paper highlights the findings of a policy-oriented research study commissioned by the Ministry of Urban Development for the design and evaluation of such a system.


Alzheimer Disease(AD)presently remains an irreversible disease.Consequently, with current research findings and clinical practices, we propose a new prevention and treatment perspective, summarized in four aspects: early-stage, comprehensive, systematic, and long-term, which are interrelated and yet show varying significance depending on the circumstances.We hope this view will help improve AD-related practices in prevention, clinical management, research and education, better equipping us to face challenges posed by AD.

Key words:
Alzheimer disease; Universal precautions; Therapy


As a basis for investigation of the safe operation of reactors, a simple mathematical model of a reactor control system was constructed. The model is not intended to give quantitative results about a reactor con trol system, but should provide a framework within which the relative safety of various alternatives can be evaluated. The model discussed was designed to bring into focus the interaction of the operator with the physical components of the reactor. (W.D.M.)


A series of new AZT conjugates with alkyl and oxyalkyl ether phospholipids was synthesized and evaluated for inhibitory activities against HIV-1 and HIV-2. The alkoxyethyl derivatives 6a-c proved 3- to 5-fold more active against HIV-1 and HIV-2 than the alkyl analogues 6d-f. A trend for higher activity with longer alkyl side-chains was observed. However, the analogues with the shortest chain possessed the most favourable therapeutic index.


e16557 Background: Varying treatment pathways are associated with management of castrate-resistant prostate cancer (CRPC), depending on whether disease is asymptomatic (asx) or symptomatic (sx), and may be multidisciplinary and multimodal in nature. We aimed to identify the most common pathways to determine and value resources used, and quantify reimbursements associated with alternative therapies.

METHODS
Common treatment pathways were identified by reviewing the CRPC literature and NCCN guidelines, and through a standardized questionnaire administered to clinicians. Financial resources associated with pathways were determined, including office visits for monitoring and PSA testing; resources were evaluated using Medicare reimbursement rates.

RESULTS
Ten alternative pathways (6 asx and 4 sx) were determined for CRPC. They include various sequences of watchful waiting (WW), hormone therapy (luteinizing hormone releasing hormone [LHRH]), antiandrogen withdrawal (AAW), ketoconazole (K), chemotherapy (docetaxel [DT], cabazitaxel [CBZ]), and immunotherapy (sipuleucel-T [ST]). Cost of regimens varied widely based on the course of therapy chosen (Table). Regimens that are mostly secondary hormonal were least expensive, at or below $25,000/patient, and resulted in a $2,500-$2,800 reimbursement/patient.

CONCLUSIONS
Pursuing secondary hormonal treatment resulted in the lowest overall cost for treatment of CRPC. Although economic factors must be considered in overall health practice, clinical guidelines, patient health status, and response to therapy should be primary determinants for a therapeutic regimen chosen for CRPC. [Table: see text].


The main goal of this paper is the validation of the use of open-source software and low-cost hardware in the equipment of audio and video capture. To achieve this, we discuss the design of an audio and video capture equipment using the low-cost SBC (Single Board Computer) Raspberry Pi 3B, the Pi Camera V.2 modules for the video capture and the capture of the audio, the two channels AD converter with USB interface using Audio class AK5371. This design will be useful to support the implementation of a camera for video surveillance. The software architecture is divided into two layers, one for user interaction using the framework for the development of web applications Flask, and another layer that implements the stages of acquisition, processing, and streaming of the data, to be used by the multimedia application framework GStreamer. This design represents an alternative to commercial equipment, using open-source software and low-cost hardware.


George Harrison Explains Why Everyone Should Play the Ukulele, With Words and Music

Well, that seals the deal. I'm going to dust off my #ukulele tonight


An optical coherence tomography-based structural vibration sensor system is reported. The system employs a halogen tungsten lamp as the low-coherence light source and a broadband CCD-based spectrometer as the detector. Unlike traditional piezoelectric accelerometer, the sensor system is non-contact and it measures the surface displacement of a sample directly. Due to the extreme broadband of the thermal light, the sensor system can offer a high axial resolution of 0.9 μm. Experimental result demonstrated that both the vibration amplitude and frequency can be quantified by the current sensor system. The measurable frequency range currently achieved is 0–250 Hz, and this could be easily increased to a few KHz if the latest CCD-based spectrometer is employed. We believe that the developed sensor system is an ideal tool for in-situ monitoring of these low-frequency micro-vibrations in high-precision manufacturing and measuring system.


Simulated annealing and parallel genetic evolution of many groups are two good ways to improve performance of genetic algorithm. This paper combines these two ideas organically and puts forward a parallel and genetic algorithm of multiple groups based on simulated annealing. The simulation results show that the algorithm can enhance the global convergence of the algorithm, accelerate the rate of genetic evolution, thus producing a satisfying global optimal value.


This study reviews the causes and symptoms of the Asian Crisis and explores its implications for urban development in emerging markets under globalization. Various factors have contributed to the Asian Crisis, but this paper focuses on two explanations (i.e., the deficiency of Asian capitalism and the risk of financial panic in an underregulated financial system). Cities in the emerging markets of Pacific Asia have been undergoing profound restructuring driven by global and local forces. The crisis requires another look at the new urbanism under globalization (e.g., the image of glittering skyscrapers that symbolize a dynamic urban economy and a building boom). The collapse of the property markets has created high property vacancy and has led to the widespread loss of financial institutions that have invested heavily in property development. The crisis has had a devastating impact on the livelihood of millions of people, highlighting the peril of unfettered globalization. It is still too early to speculate on the long-term consequences of the crisis, but certainly the crisis may not be seen as the triumph of globalization or the decline of state-led economic growth. As the dialectic interactive process between global and local forces, urban development in the post-crisis era may see growing local resistance because the crisis has intensified the global-local contradiction in a dramatic way. [Key words: the Asian Crisis, globalization, emerging markets, urban governance.]


The uniaxial compression and deformation performance of dry-mixed self-compacting concrete(SCC) were discussed.Through the test,the dry-mixed SCC including three water rates was researched to obtain their uniaxial stress-strain curves.The uniaxial stress-strain curve characteristics were analyzed and the equations of the normalized stress-strain curves were proposed based on regression analysis.The similarities and differences between the elastic modulus of dry-mixed SCC and normal concrete were contrasted and analyzed,and then the relation between the elastic modulus and compressive strength was regressed according to the regression model in the current valid code.A regression formula which can be suitable for the elastic modulus of dry-mixed SCC is proposed.The results indicate that the elastic modulus of dry-mixed SCC is lower than that of normal concrete and it is more important for water rates to influence the stress-strain curves of dry-mixed SCC than coarse aggregate ratio.


The development of PE industry can improve the development of national economy.In recent years,our PE industry developed to some extent,but compared with developed countries,there still exist gaps.We should foster new concept for PE industry development,speed up the reform pace,cultivate specialized talents,establish PE operation mechanism,and perfect external environment for PE industry development to promote the healthy development of PE industry.


In this paper, I would like to make a comparison between non -argumentative resources (such as Socrates' decision to write poetry, the mention of the teletai and the bakchoi as those who have philosophized correctly and the 'incantations' to soothe the soul) on the one hand, and the well -known rational arguments presented in the dialogue, on the other hand, with the aim of establishing what weight each of them has to hold Socrates' hope. I assume that it is not possible to separate these two types of resources, though they can be clearly distinguished and subordinated. I understand that Plato deliberately provides a fine web made of both powers, because emotion and reason, myth and logos, imagination and argument, poetry and philosophy, desire and intellectual prescriptions are for him an expression of man's natural constituent elements that deserve our care in due proportion. This Socratic devotion to reduce the fear in the hearts of his friends and to awaken in them the desire of spending their lives philosophizing, turns out to be an interesting challenge to us. I will also attempt to make sense of some of the issues that provoke Socrates' puzzles, such as the Beatriz Bossi, 'La esperanza de Socrates: ?cuestion de argumentos o encantamientos? (Notas al Fedon)', p. 147-182 n. 16, jan.-apr. 2016 149 mixed nature of pleasure, the divine 'order' to produce poetry at the last moment (i.e. a lower kind of music, compared to philosophy) and the meaning of a hope founded on a risky belief.


Some PT-symmetric non-Hermitian Hamiltonians have only real eigenvalues. There is numerical evidence that the associated PT-invariant energy eigenstates satisfy an unconventional completeness relation. An ad hoc scalar product among the states is positive definite only if a recently introduced "charge operator" is included in its definition. A simple derivation of the conjectured completeness and orthonormality relations is given. It exploits the fact that PT symmetry provides a link between the eigenstates of the Hamiltonian and those of its adjoint, forming a dual pair of bases. The charge operator emerges naturally upon expressing the properties of the dual bases in terms of one basis only, and it is shown to be a function of the Hamiltonian.


The present study in isolated rat lungs demonstrates that nitric oxide gas (• NO, 70 nM) added to the perfusate containing a small amount of hemolysate [175 μ1 of lysed red blood cells (RBC) per 50 ml of Earle's balanced salt solution (EBSS)] triggered profound and sustained vasoconstriction. Vasoconstriction was not observed when •NO was added to lungs perfused with washed intact rat or human RBC or with oxyhemoglobin (Hgb 20 μM). The presence of hemolysate in the perfusate also caused vasoconstriction in response to n‐acetyl‐cysteine (50 μM), glutathione (10–4 M), or ascorbic acid (10~4 M) and potentiated greatly the vasoconstrictor response to 5 mM KC1. Not only • NO, but also nitroprusside (SNP) or L‐arginine and paradoxically three • NO synthesis inhibitors, including N‐monomethyl L‐arginine, L‐NAME, and nitroblue tetrazolium, which have different mechanisms of action, each caused in the presence of hemolysate large vasoconstrictive responses. Hemolysate itself enhanced O2 consumption by slices of lung; no effects of this dose of • NO on lung slice respiration were seen in the absence of hemolysate. Both Hgb and hemolysate lowered perfusate cGMP levels to the same degree suggesting that the vasoconstrictive response was not due to unique effects of hemolysate on guanylyl cyclase. Addition of superoxide dismutase (SOD) and catalase (CAT) to the hemolysate containing perfusate, or addition of a cyclooxygenase or 5‐lipoxygenase inhibitor, virtually abolished the • NO induced vasoconstriction. The latter data are consistent with the concept that exposure of the vasculature to hemolysate may result in the formation of peroxynitrite. However, SOD and CAT did not abolish the pulmonary vasoconstriction induced by L‐arginine or by NAC. Our data indicate that hemolysate has profound effects on lung vessel tone regulation and on lung tissue mitochondrial function, yet the precise molecular mechanisms responsible for the action of hemolysate are likely to be very complex.—Voelkel, N. F., Lobel, K., Westcott, J. Y., Burke, T. J. Nitric oxide‐related vasoconstriction in lungs perfused with red cell lysate. FASEB J. 9, 379–386 (1995)


The security of symmetric key primitives comes from their exposure to public scrutiny in the context of competitions such as Advanced Encryption Standard, Secure Hash Algorithm 3, or currently CAESAR. However, due to the increasing number of primitives subjected to these competitions, the quality of the scrutiny relies on the availability of automated tools. Although SAT solvers have already proved useful for the automated analysis of these primitives, there is a lack of practical software tools for this purpose. This study describes a framework that aims to make SAT-based analyses accessible to cryptographers. The framework is implemented in a free open-source tool called CryptoSAT which is available in the public domain.


Medullary thyroid carcinoma (MTC) is a rare subtype of thyroid cancer. Other than gain‐of‐function RET mutations, no other genetic, lifestyle or environmental risk associations have been established for MTC. Several case‐control studies and meta‐analysis have examined the risk association of different SNPs with MTC in different populations but with contradictory or inconclusive results.


This study was conducted to investigate yield of extract, total phenolic compounds content, electron donating activity, nitrite scavenging activity, superoxide dismutase like activity of the radish leaves (Raphanus sativus L.) extracts. Radish leaves extracts were prepared using water extraction, 50% ethanol extraction and 50% methanol extraction. The yield of Kwandong radish leaves extracts without blanching treatment (DRLK) was 26.56∼32.56% and the extract yield of Minongdanbaek radish leaves without blanching treatment (DRLM) was 34.34∼36.90%. On the other hand, the yield of samples with blanching treatment was a lower range value of 18.70∼23.56% than samples without blanching treatment. In the total contents of phenolic compound, samples with and without blanching treatment were 49.1∼59.4 ㎎/g and 53.41∼62.08 ㎎/g, respectively. Minongdanbaek radish leaves extracts (DRLM, BDRLM) showed higher contents value than Kwandong radish leaves extracts (DRLK, BDRLK) in the total phenolic compounds. Samples without blanching treatment showed electron donating activity above 80%, nitrite scavenging activity of 36.63~51.17% and superoxide dismutase like activity of 38.53~45.38%. Generally, Kwandong samples showed a little higher activity more than Minongdanbaek samples in the electron donating activity, nitrite scavenging activity and superoxide dismutase like activity. Also, radish leaves extracts without blanching treatment showed high physiological activities.


K2CO3 supported on activated carbon (K2CO3/AC) is a promising means to remove low-concentration CO2 from confined spaces. In this removal process, physical adsorption plays an important role but it is difficult to quantify the amount of CO2 adsorbed when both H2O and CO2 are present. The linear driving force mass transfer model is adopted to study the CO2 adsorption kinetic characteristics of K2CO3/AC by analyzing the experimental data. The effect of K2CO3 and H2O on the adsorption of CO2 in K2CO3/AC was also evaluated. K2CO3 loaded on the support is found to increase the mass transfer resistance but decrease the activation energy required for the physical adsorption process. The presence of water vapor is disadvantageous to achieve high physical adsorption capacity since it enhances the chemical sorption in the competitive dynamic sorption process.


Written by Eric Finley. Retired attorney and former Texas Tech law professor Hadley Edgar was included in the panel of retired legal experts.


Abstract : Characterization was completed on two multi-layered cold spray coatings. The samples consisted of flat steel substrates coated with 820 microns of Ni and a topcoat of 210 microns Ta deposited via cold spray. Characterization was completed to determine thickness, structure, and adhesion of the coatings. To determine coating thickness and structure metallographic analysis was completed. Adhesion was analyzed via groove adhesion testing. Further analysis to determine constituents of cold spray coatings was completed via SEM-EDS.


Let m be any positive integer, R be a ring with identity, be the matrix ring of all m by m matrices eve. R and be the multiplicative group of all n by n nonsingular matrices in . In this pape., the following are investigated: (1) for any pairwise coprime ideals in a ring R, is isomorphic to and is isomorphic to (2) In particular, if R is a finite ring with identity, then the order of can be computed.


Based on a study of the training programs for specialists in "Physical Education and Sports" at several Bulgarian universities and on extensive personal theoretical and practical experience, the author describes the competencies and knowledge that a specialist in physical education and sports needs to have.


In precision interferometry, the cross coupling of angular beam jitter into the pathlength readout can be an important effect. One possibility to minimize the resulting noise is to use imaging optics systems. The simplest imaging optics system that can be used for this purpose consists of two spherical lenses. In the process of investigating such systems it was found that they can transform Gaussian beams in fundamental mode from stigmatic into simple and even general astigmatic. Effectively, it means that, for instance, the spot shape of a Gaussian beam can change from circular (stigmatic) to elliptical (astigmatic) after transmission through a lens system, and the spot ellipse might even rotate (general astigmatic) along the beam path. This thesis provides a study of the stigmatic, simple astigmatic and general astigmatic models of a Gaussian beam in fundamental mode. Each model is suitable for the procedure of simulating interferometer signals, which is also described in this thesis. The most general, and thus the most accurate model of a Gaussian beam in fundamental mode is the general astigmatic beam model. However, this model is also the most complex, and to the author's knowledge the least discussed in literature. The general astigmatic model presented in this thesis comprises the previously available information from different sources, together with a derivation of the equations that allow beam transformation at a surface. In order to prove reliability of the general astigmatic beam model an experimental verification has been performed. Within this verification the evolution of the intensity ellipse of a general astigmatic beam has been studied. This general astigmatic beam was obtained by transmitting a simple astigmatic beam through an optical system consisting of two cylindrical lenses, both experimentally and in a simulation. The results obtained were compared and showed very good agreement. In this thesis the impact of the beam model choice on the pathlength readout has been studied using the designs of imaging optics systems for the test mass interferometer in a LISA-like mission. In order to estimate the impact of the use of simplified beam models, a set of realistically misaligned setups was analyzed, and the results obtained with different models were compared. This investigation has shown that within the current measurement uncertainties of the parameters of the lens system, and of the initial beams, the choice of model does not affect the range of the possible cross


"Vengeance is one of the most feared forms of human violence and also offers privileged ground for studying this violence in itself. For psychoanalysis, perversion is the psychic organization which most clearly illustrates how this desire for vengeance originates in the human psyche. Its aim is nonetheless paradoxical, as I tried to show in one of my recent books with titled La perversion, se venger pour survivre (Bonnet, 2008) or perversion, vengeance as a means of survival. For if the perverse person has such an investment in vengeance, it is paradoxically in order to survive and to counterbalance another deadly violence, fearsome in another way, which threatens them relentlessly from within. The perverse person counterbalances this death violence by investing every facet of vengeance and it is important to identify these in order to defuse the immediate dangers. We then observe that they invests this survival violence in two ways: either by taking it out on others, whom they transforms into survival objects in the most serious perversions wherein the subject is entirely driven by the dialectic of violence; or by investing in some or another facet of the violence with much screaming and kicking in such a way that its consequences for the other are contained: this varies from Don Juanism to masochism and fetishism, and includes all the varieties of narcissism and voyeurism that are rampant today."


Abstract We conducted two experiments to examine the processing of garden path sentences such as While the boy scratched the dog yawned loudly. We varied the ambiguous phrase of such sentences so that it was either short (the dog), long due to the inclusion of a relative clause (the dog that was hairy), or long due to the inclusion of prenominal adjectives (the big and hairy dog). The subjects' task was to read each sentence while their eye movements were monitored and then judge whether the sentence was grammatical. We found that early closure sentences were judged grammatical less often than were late closure sentences, and sentences with a long ambiguous phrase, particularly one made long through the insertion of a relative clause, were judged grammatical less often than were those with a short ambiguous phrase. The reading time data, however, showed a curious pattern. Reading times on the disambiguating word of the sentences (yawned in the above example) were longer for early closure than for late closure sentences, as expected, but reading times were shorter for sentences with a long ambiguous phrase. We argue that the latter finding reflects subjects' tendency to read more quickly as they proceed through a sentence. We suggest that researchers interpret any studies showing differences in the processing of syntactically easy and difficult constructions with extreme caution, unless the words being compared in these studies are preceded by the same number of words in the different experimental conditions.Resume Nous avons effectue deux experiences sur le traitement des phrases trompe - l'oeil telles While the boy scratched the dog yawned loudly. Nous avons varie la formulation ambigue de ces phrases pour qu'elle soit breve (the dog), longue en raison de l'insertion d'une proposition relative (the dog that was hairy) ou longue par l'insertion d'adjectifs anteposes (the big and hairy dog). Les sujets devaient lire chacune des phrases pendant que leurs mouvements oculaires etaient enregistres, puis ils devaient juger de leur grammaticalite. Nous avons constate que les phrases a clo@ture ha@tive etaient jugees moins souvent grammaticales que les phrases reposant sur le principe de clo@ture tardive. Nous avons egalement constate que les phrases ayant une formulation longue et ambigue, en particulier lorsqu'une proposition relative y etait inseree, etaient jugees grammaticales moins souvent que celles dont la formulation etait courte et ambigue. Un patron etrange ressort des temps de lecture. Comme prevu, les temps de lecture enregistres pour le terme desambiguisant des phrases (yawned dans l'exemple cidessus) etaient plus longs dans le cas des phrases a clo@ture ha@tive; en revanche, ils etaient plus courts pour les phrases longues et ambigues. Ce resultat montre, a notre avis, que la vitesse de lecture des sujets tend a s'accroi@tre d'un bout a l'autre de la phrase. Nous invitons les chercheurs a interpreter avec force circonspection toutes les etudes revelant des differences dans le traitement des constructions syntaxiquement complexes et simples, a moins que les mots qui y sont compares soient precedes du me@me nombre de mots dans les differentes conditions experimentales.Reading involves a number of inter - related processes. Readers must access the lexical reprentations of words and combine them so as to reflect the overall meaning of the sentence. For example, consider the ambiguous sentence Mary saw the boy with binoculars. The phrase with binoculars could function either as the modifier of the verb phrase that includes saw, indicating that Mary was the one in possession of the binoculars, or as the modifier of boy, in which case the boy is the one with the binoculars. These different syntactic attachments of the phrase with binoculars have different semantic consequences, resulting in different truth conditions for the two possible semantic interpretations of the ambiguous sentence. An important process during reading, then, is to create phrases and assign them to their appropriate grammatical roles, a process we will refer to as parsing. …


. The well-known Arcadian inscription (SIG. 314B = IG. V. 2. 550) mentions among the winners of Lycian Games in 308 BC a certain Macedonian: Lagus, Ptolemy's son. According to fairly well established opinion in scienti fi c community, this Lagus was the son of the future king of Egypt, Ptolemy I Soter and the former Athenian hetaera Thais. The above-stated inscription represents an important source of the dynastic history of the fi rst Ptolemies. First, thanks to this document, modern researchers were able to de fi nitively fi nd out that Ptolemy and Thais really had two sons, whose names were Lagus and Leontiscus. In addition, the mentioned inscription testi fi es, that Lagus, having reached the age of majority at the time of his participation in games of 308 BC, and possibly his brother, Leontiscus, were born in the last years of life of Alexander the Great. In addition, it is the argument, proving, that Thais had the legal status of the wife of Ptolemy before 308 BC. Otherwise, Lagus could not participate in the sacred Lycian Games. Finally, the given source indicates the absence of hostility between Lagus and his stepbrother: the next king of Egypt, Ptolemy II Philadelphus. In particular, the young Ptolemy II benevolently accepted the "Hymn to Zeus" by Callimachus, where the mythological tradition connected with happy for the Lagus the Lycian Games was mentioned.


It is commonly noted that French velar plosives tend to take a fronted realization when followed by a front vowel. These observations are generally not accompanied by representative data, and consequently, little is known about the actual characteristics and spread of the phenomenon. This study provides a corpus analysis of velar palatalization in contemporary French, and addresses the potential linguistic and sociolinguistic factors involved. Moreover, the synchronic results are considered in the light of the palatalization processes that took place in the history of French.


A 25-year-old woman had the chief complaint of recurrent episodes of dyspnea and wheeze. Asthma had been diagnosed at infant years and sometimes experienced asthma attacks. She graduated senior high school and entered technical school in Tokyo.
She received fluticasone (400μg daily) but exacerbation continued after she became an office clerk. She returned Kurashiki in October 2001 but had wheeze and asthma exacerbations.
She was admitted to our hospital for evaluation and treatment of bronchial asthma on August 2, 2002. After admission, her symptoms subsided within some days. She was treated with montelukast and perilla seed oil-rich supplementation . The number of eosinophils decreased, decrease was observed in leukotriene (LT) B4 generation and in LTC4 generation, and pulmonary function improved following montelukast and perilla seed oil-rich supplementation for 4 weeks. The patient had no exacerbation under treatment and was discharged from the hospital on September 2, 2002. For some patients with persistent asthma, inhaled corticosteroids may fail to achieve adequate control possibly because corticosteroids do not completely inhibit the synthesis and release of cysteinyl leukotrienes (cysLTs) in the lung. Montelukast blocks the interaction of cysLTs with their receptor and resulting downstream events and perilla seed oil-rich diet suppresses LT generation. Combination therapy with montelukast and perilla seed oil-rich diet is more effective than montelukast or perilla seed oil-rich diet alone because of additive effects of montelukast with perilla seed oil-rich diet. We suggest that montelukast and perilla seed oil-rich supplementation are effective options when bronchial asthma patients receive inhaled corticosteroid but exacerbation continues.


Informal analysis of many usability tests suggests that there is regularly one participant that is substantially slower than all the others. Moreover, such outliers are more extreme and more frequent than would be predicted by a normal distribution. We propose using a rational model to explain the outliers and the work described here begins to parameterise the model based on empirical data to provide accurate analyses of user performance. This prediction appears to be correct and the model begins to reflect the outlying performance. Moreover, by using an executable model, we believe that it could be used in future as an analytical tool to help designers improve usability for those users who are struggling the most.


Hepatotoxicity of amiodarone has long been described and consists mostly of mild and delayed onset elevation in liver function tests. Fulminant hepatitis, however, is much rarer and attributed to the parenteral administration of the drug. The mechanism of injury is yet to be understood, though multiple theories have been proposed. This case report aims at highlighting the importance of monitoring patients receiving intravenous amiodarone therapy to detect severe acute liver injury and showcase the appropriate management thereafter.

Our patient is a 79-year-old male who presented with epigastric pain that was crampy, intermittent, and aggravated upon exertion. His heart rate was 93 beats/min and cardiac auscultation revealed an irregular heart rhythm. His electrocardiogram revealed atrial fibrillation. He was given intravenous amiodarone with a total dose of 950 mg and developed acute liver failure with extremely elevated liver function tests 48 hours after initiating the drug. After discontinuation, liver function tests returned to baseline within 10 days and the patient was discharged home.

Physicians should be aware of the potentially life-threatening complications, including severe acute liver injury, by closely monitoring liver function tests following the administration of the drug and immediately discontinuing therapy if toxicity was detected.


Objective To compare the clinic effect of the locking compression plate (LCP) fixation and the anatomical plate in treatment of high-energy distal tibial fractures. Methods The study involved 42 patients with high-energy distal tibial fractures treated between May 2003 and May 2009. The anatomical plate group included 24 patients ( 16 males and 8 females, at average age of 39 years), of whom there were 13 patients with type A fractures, five with type B and six with type C according to the AO/ASIF classification. The LCP group included 18 patients ( 15 males and 3 females, at average age of 40 years), of whom there were 11 patients with type A fractures, three with type B and four with type C according to the AO/ASIF classification. All the patients were followed up for 8-17 months. Their functional and radiographic outcomes were collected. The operation time, intra-operative blood loss, X-ray exposure, bone healing time, post-operative complications and therapeutic effects were compared between both groups. Mazur's criteria was used to evaluate the function of the ankle. Results The LCP group was followed up for average 11.6 months and the anatomical plate group for average 14.2 months, which showed fracture healing in all the patients. The bone graft in the anatomical plate group was used more frequently than the LCP group, while the X-ray exposure in the LCP group was much more than that in the anatomical plate group. The operation time, incision size, blood loss, postoperative complications and radiographic bone healing time in the LCP group were significantly less than those in the anatomical plate group. Conclusions Both the LCP and anatomical plate are effective methods for the high energy distal tibial fractures. LCP has advantages of less trauma, quick fracture healing and less complications, is consistent with the biomechanics of internal fixation and hence is an ideal method for the treatment of the high-energy tibial fractures.

Key words:
Tibia;  Fractures;  Fracture fixation,internal


Mobile robots are ubiquitous. Such vehicles benefit from well-designed and calibrated control algorithms ensuring their task execution under precise uncertainty bounds. Yet, in tasks involving humans in the loop, such as elderly or mobility impaired, the problem takes a new dimension. In such cases, the system needs not only to compensate for uncertainty and volatility in its operation but at the same time to anticipate and offer responses that go beyond robust. Such robots operate in cluttered, complex environments, akin to human residences, and need to face during their operation sensor and, even, actuator faults, and still operate. This is where our thesis comes into the foreground. We propose a new control design framework based on the principles of antifragility. Such a design is meant to offer a high uncertainty anticipation given previous exposure to failures and faults, and exploit this anticipation capacity to provide performance beyond robust. In the current instantiation of antifragile control applied to mobile robot trajectory tracking, we provide controller design steps, the analysis of performance under parametrizable uncertainty and faults, as well as an extended comparative evaluation against state-of-the-art controllers. We believe in the potential antifragile control has in achieving closed-loop performance in the face of uncertainty and volatility by using its exposures to uncertainty to increase its capacity to anticipate and compensate for such events.


ALPHONSE CHAPANIS and BERNARD A. GROPPER (The EfSect of the Operator's Hondedtiess on Sonre Directional Stereotypes it1 ControlDisplay Relationships) ALPHONSE CHAPANIS is Professor of Psychology at The Johns Hopkins University. He received his B.A. from the University of Connecticut in 1937 and his M.A. and Ph.D. degrees from Yale in 1912 and 1913, respectively. From 1912 to 1916 he worked in the Aero Medical Laboratory at the Wright Air Development Center, Ohio. In 1916 he joined the staff of the Systems Research project of The Johns Hopkins University and has been continuously associated with the University since that time. In 1953-1954 he had a leave-ofabsence from the University which he spent as a member of the technical staff at the BellTelephone Laboratories. He took another leave-of-absence in 1960-1961 to serve as Liaison Scientist in the Office of Naval Research Branch Office of the Embassy of the United States, London, England. He is past president of the Society of Engineering Psychologists (1959-1960) and of the Human Factors Society (1963-1964). In 1963 he received the Franklin V. Taylor Award from the Society of Engineering Psychologists "for outstanding contributions to the field of engineering psychology." BERNARD A. GROPPER is working toward a Ph.D. in psychology at The Johns Hopkins University where he holds a graduate fellowship. He received a B.S. in psychology from the University of Maryland in 1964 and an M.A. in psychology from the Johns Hopkins University in 1966. While an undergraduate he worked with Vitro Corporation and The Applied Physics Laboratory's Satellite Systems Engineering Group. He has recently worked for the Martin Company in their manned space simulation studies as a Human Factors Engineer and with the Applied Physics Laboratory's Space Life Sciences Group as a Human Factors Psychologist. STANLEY N. ROSCOE (Airborne Displays for Flight and Navigation) is Manager of the Display Systems Department of Hughes Aircraft Company, Culver City, California. He received his A.B. in speech and English from Humboldt State College in 1913 and his M.A. and Ph.D. in experimental (engineering) psychology from the University of Illinois in 1917 and 1950, respectively. From 1933 to 1916 he served in the Army Air Corps as a pilot instructor in the Western Flying Training Command and as a transport pilot in the Troop Carrier Command in the Pacific Theater. From 1916 to 1952 he was successively a Research Assistant, Research Associate and Assistant Professor at the Aviation Psychology Laboratory, Department of Psychology, University of Illinois. During this period he conducted a series of pioneer flight and simulation experiments on aircraft attitude display variables and on pictorial map-type navigation displays. In 1952 he joined Hughes Aircraft Company as the first human factors engineer in industry specifically trained in engineering psychology. He established the Cockpit Research Group to perform research and development on advanced displays and controls for Hughes interceptor fire-control and navigational systems. During the tenure of the late Alexander C. Williams, Jr. at Hughes, this group evolved organizationally into the present Display Systems Department. Dr. Roscoe has been primarily responsible for the advent of operational maptype horizontal situation displays in military aircraft and the use of dynamic simulation as a design tool in the development of radar displays and other high-resolution image producing sensor systems. He is a past President of the Human Factors Society (1960-61) and has been a Member of the Executive Council continuously since 1959. ALBERT ZAVALA and ARLENE M. GEIST (Cotriporrent-Total Task Relationships: Sitriple and Sequential Proctice Eflects) ALBERT ZAVALA received the h1.A. from Michigan State University and the Ph.D. from Kansas State University. From 1959 to 1960, at Michigan State, he did studies of driving skill decrement as a function of long distance driving in automobiles. In 1961 he held a position as Research Scientist with the Honeywell Company


Abstract Counterproductive work behavior is detrimental to the organization or to coworkers. It includes both breaking rules or laws, as well as social norms. Many authors show a negative relationship between this behavior and work satisfaction, surmising that the lack thereof – and the ensuing desire to 'get back' at the employer – are the seeds of workplace deviance. A study carried out in Polish organizations found this relationship to be less clear. The study concerned work satisfaction and counterproductive behavior, organizational justice, stress at work and propensity for aggressive behavior. A cluster analysis identified a group of individuals in whom relatively high levels of job satisfaction are nevertheless accompanied by proclivity for counterproductive behavior. The configuration of results suggests that this group resorts to counterproductive behavior because of an inability to balance difficulties at work with personal inclinations. The implications of these results for personal management is discussed in the conclusions.


The simplest type of insensitive gold-leaf electroscope, as used in radioactive work, is critically and experimentally investigated with a view to increasing the accuracy of measurements made with this instrument. Results are quoted, showing a consistency of the order of 1 in 1000; and highly accurate comparisons are shown to be possible between radioactive sources of widely differing magnitudes.


Inflammation and cellular stress induce the expression of C‐reactive protein (CRP) gene in hepatocytes. In this study, we investigated the role of transcription factor OCT‐1 in the regulation of the CRP promoter in human hepatoma Hep3B cells. The OCT‐1 site is located in a 32 bp long region (−43/−74) on the CRP promoter that also contains binding sites for NF‐κB, HNF‐1/‐3 and C/EBPβ. The OCT‐1 site is away from the C/EBP site but overlaps the NF‐κB and HNF‐1/‐3 sites. EMSA, using a probe (−38/−78) derived from the CRP promoter and nuclear extracts from untreated Hep3B cells, showed that the binding of OCT‐1 to its site was unaffected by the presence of the C/EBP site. However, the intensity of the HNF‐1‐containing complex formed on the probe influenced the composition of the OCT‐1‐containing complexes. These data indicate that the relative levels of HNF‐1/‐3 and OCT‐1 in the nuclei may contribute to the regulation of CRP transcription. In luciferase transactivation assays, overexpressed OCT‐1 repressed (IL‐6+ IL‐1β)‐induced CRP promoter‐driven luciferase activity. The amount of OCT‐1 required to repress CRP transcription was less when the HNF‐1/‐3 sites on the promoter were mutated, supporting the roles of HNF‐1/‐3 in OCT‐1‐mediated CRP transcription. We conclude that OCT‐1 works as a repressor of CRP expression and that OCT‐1, in cooperation with HNF‐1/‐3, participates in regulating CRP expression. NIH R01HL71233


Background : Upper Airway Obstruction is a critical problem. Tracheostomy done by otolaryngologists generally yield good results. Objective : To study our experience in the treatment of upper airway obstruction by tracheostomy at Rayong Hospital by 4 otolaryngologists . Method : We retrospectively studies a consecutive series of patients underwent tracheostomy from October 2006 to September 2009. there were 27 males and 5 females with the ages of 25-82 years old. The causes of upper airway obstruction and the results of procedure were discussed. Results : Thirty Cases (93.7 Percent) had the age over 40 years old. Carcinomas were the most common cause (78.1 Percent) while the next was neck injury (12.5Percent). All patients of this group were underwent tracheostomy with satisfactory results. Conclusion : Tracheostomy is the treatment of choice for the upper airway obstruction at the levels of oro-hypo-pharynx, larynx and upper trachea. Keywords : Upper Airway Obstruction, Tracheostomy


The underground works projects include a share of uncertainty, often significant, and related to the knowledge of ground which can only be partial before carrying out the work. Consequently the forecast construction budget must include in addition to the work costs estimate a margin to protect against the uncertainty, the evaluation of which comes under the responsibility of the contracting authority.


In this paper, we propose a new topology extraction approach for 3D objects. We choose a normalized robust and simplified geodesic-based Morse function to define skeletal Reeb graphs of 3D objects. In addition to scale invariance, we ensure, by using a geodesic distance, the invariance of these graphs to all isometric transforms. In our Reeb graph construction procedure, we introduce important improvements and advantages over existing techniques. We define an efficient sampling rate based on the characteristic resolution intrinsic to each 3D object. Then, we provide a geometry preserving approach by replacing the traditional intervals of a Morse function by its exact level curves. Moreover, we take advantage of the resulting ordered adjacency matrices that describe our Reeb graphs, to introduce a new measure of similarity between the corresponding objects. Experimental results illustrate the computational simplicity and efficiency of the proposed technique for topological Reeb graphs' extraction. The experiments also show the robustness of this approach against noise and object remeshing.


In a fairly even encounter Salford City claimed all 3 points with a spectacular winner from substitute Wes Bancroft 8 minutes from time. Both attacks ...


The search for novel chemical classes of anti‐malarial compounds to cope with the current state of chemoresistance of malaria parasites has led to the identification of Plasmodium falciparum aminopeptidase 1 (PfA‐M1) as a new therapeutic target. PfA‐M1, known to be involved in the hemoglobin digestion cascade which helps to provide most of the amino acids necessary to the parasite's metabolism, is currently considered as a promising target for anti‐malarial chemotherapy. However, its immunogenic properties have not yet been tested in the Gabonese population. In Gabon, the prevalence of malaria remains three times higher in semi‐urban areas (60·12%) than in urban areas (17·06%). We show that malaria‐specific PfA‐M1 antibodies are present in children and increase with the level of infection. Children living in semi‐urban areas have higher anti‐PfA‐M1 antibody titers (0·14 ± 0·02 AU) than those living in urban areas (0·08 ± 0·02 AU, P = 0·03), and their antibody titers increase with age (P < 0·0001). Moreover, anti‐PfA‐M1 antibody titers decrease in children with hyperparasitemia (0·027 ± 0·055 AU) but they remain high in children with low parasite density (0·21 ± 0·034 AU, P = 0·034). In conclusion, our results suggest that malaria‐specific PfA‐M1 antibodies may play an important role in the immune response of the host against P. falciparum in Gabonese children. Further studies on the role of PfA‐M1 during anemia are needed.


In order to remove the danger of rockburst, large diameter drilling injection coal seam fracturing process was simulated numerically. The effect of single hole with different lateral pressure coefficients and multihole porous water fracturing under different modes of arrangement were also analyzed. The results show that water injection can relief pressure in a wide range and the cracks waken the stress of coal and the water in the hole of coal change the physical and mechanical properties which can prevent rock burst effectively. The crack propagation direction has a correlation with lateral pressure coefficient, which changes from vertical to horizontal direction with lateral pressure coefficients increasing. Different pressure relief with different hole arrangement mode, pressure relief range in square arrangement is 35.8% and 31.3% higher than that in single-row and three-cornered along the vertical direction. So, square arrangement mode is more adaptable to mine thick coal seam of rock burst mine. The conclusion presents important references for safety mining of rockburst mine.


The functional groups that undergo nucleophilic acyl substitutions are called carboxylic acid derivatives: these include carboxylic acids themselves, carboxylates (deprotonated carboxylic acids), amides, esters, thioesters, and acyl phosphates. Two more examples of carboxylic acid derivatives which are less biologically relevant but important in laboratory synthesis are carboxylic acid anyhydrides and acid chlorides.


Currently, age is characterized, on the one hand, by the existence of governance systems that are gradually eroding the Welfare State and, on the other hand, by the implementation of business management models based on precarious work and a massive reduction in jobs. This work aims to analyze the degree of happiness perceived in the group of Spanish entrepreneurs (either with or without employees), compared to that perceived by employees (whether permanent or temporary); and if that happiness is associated with certain socio-demographic variables gender, level of studies and income level).For this reason, there is a need to consider these working hypotheses proposed. Starting with the general null variable (H0), its opposite is established: H1. There is a relationship between the type of professional situation (employee, businessperson, self-employed, cooperative, etc.) and happiness; that is, there is an association between the different employment categories (represented by the variable professional situation) and the value given to the variable that measures the degree of perceived happiness. The averages of the distributions for each category are not similar.

Keywords: Happiness, Entrepreneur, Wage Earners, Well-being, Professional Situation.


The article presents a measurement solution and image reconstruction algorithms using radio-frequency tomography. In this method, the action requires measuring the strength of the radio signal between the transmitter and the receiver. The under pressure of the measurement value of the signal strength changes as a result of the absorption, reflection or dissipation of electromagnetic waves. Radio tomography can determine the position of a man in closed rooms. It can be used for navigation and locating inside buildings. The solution works on the basis of Bluetooth 4.0 Low Energy signals and devices emitting radio signals.


The bunch length of the high-intensity proton beam ejected from the CERN SPS into LHC must be reduced to fit into the 400MHz LHC buckets. This will be done using a new 400MHz superconducting RF system in the SPS. Above transition bunch compression is obtained with a cavity tuned slightly below the bunch frequency, thus giving a very high capacitive impedance. Such a system would however be extremely critical and very likely unstable without strong RF feedback. To keep the required RF power at an acceptable level during the ramp, the beam, which occupies only a third of the SPS, is accelerated in a variable harmonic mode to place the beam spectrum substantially above the cavity bandwidth. On the flat top, when the beam spectrum is moved towards the cavity resonance, the phase and amplitude of the reference voltage, including its modulation at the revolution frequency are programmed to keep the required RF power to a minimum. This scheme is described in detail together with the prototype 400MHz superconducting cavity already installed in the SPS. Initial tests with beam will also be reported.