The rapid development of new energy vehicles has brought new problems--how to deal with retired batteries. Although the use of retired electric vehicles (EVs) batteries in the energy storage system saves the cost, the state of health (SOH) of each battery is difficult to be consistent, which affects the life of the entire energy storage system. Therefore, this paper proposes a Nash equilibrium consistency control method based on the complete information game, which can adjust the adopted depth of discharge (DOD) based on the current SOH and expected SOH. As a result, the SOH eventually tends to be consistent. The influence of energy storage battery SOH on state of charge (SOC) consistency is fundamentally solved, which provides a theoretical basis for battery SOH consistency equalization. It improves the utilization rate of energy, prolongs the service life of the energy storage battery, and reduces the operating cost. Simulation results demonstrate the effectiveness of the proposed method.


The student support services in an Open Distance e-Learning system are a vitally important component of achieving quality education. The focal point of this paper was to assess the student support services in the Open and Distance e-Learning (ODe-L) programme in one selected university in Zimbabwe. The study employed a mixed methods research approach following a parallel convergent research design. The study population comprised ODe-L students, coordinators, and lecturers. A stratified random sampling method was employed to come up with a study sample of 50 participants, consisting of 40 students, 3 coordinators, and 7 lecturers. Online questionnaires, semi-structured interviews, and focus group discussions were used to generate data on student support services within the ODe-L setting. Quantitative data was analysed descriptively and qualitative data was analysed thematically. The study revealed that the ODe-L program offered academic, administrative, and emotional support services. A Chi-square test based on Kendall's Coefficient of Concordance was used to test the level of agreement among the rankings of the support services in terms of their importance and accessibility. There was high level of agreement among the rankings done by the participants. Learning support services were ranked the most important and accessible support service category by students. Emotional support services were ranked the least accessible. The results implied that the ODe-L students were not adequately given emotional support, which was also deemed important. The researchers recommended that the university where the study was conducted should employ student advisors who have expertise in adult student guidance and counselling. Based on the findings of this study, the researchers recommend that there is a need for lecturers and student affairs department to inform students about available support services. The researchers recommended that the university where the study was conducted should employ adequate student advisors who have expertise in Learner Support Services.


In order to improve the image quality of (Multiple-Input Multiple-Output, MIMO) sparse linear array, this paper deeply explored the block sparse characteristics of imaging targets. By introducing LLP algorithm, firstly, the elements of echo signal are divided into 4-length blocks, and each block matrix is transformed into 2-2-size matrix. By using a logarithmic determinant function which has the ability to promote the block-sparsity and local smoothness simultaneously, the low rank of these 2 × 2 matrices is improved. Finally, the iterative weighting method can efficiently reconstruct the objective image by iteratively minimizing a surrogate function of the original objective function. Simulation results show that the proposed method can get higher quality target image than the traditional algorithm.


Although similar in their lonely, self-respecting, sentimental with their own ideas on love, Nobuko and Shafei, each depicted in Miyamotoyuriko's and Dingling's novels, are in essence totally different types of characters in their alienation from tradition. Shafei, a typical image of the 1930's China in pursuing individuality and freedom in choosing her own lover and marriage, is complex and truthful,a little sadist and self-examining, giving readers artistic fragmentary beauty. However, Nobuko, a fictitious and conceptual character, embodying what the author conceives an ideal lady, indulges in self-admiration and too good to be true, cannot but give readers a false impression.


This thesis deals with active 3D reconstruction from camera-projector systems. Standard reconstruction methods use coded light patterns that come with their strengths and weaknesses. We introduce unstructured light patterns that feature several improvements compared to the current state of the art. The research presented revolves around three main axes : robustness, precision and comparison of existing unstructured light patterns to existing methods. Unstructured light patterns stand out first and foremost by their robustness to interreflections and depth discontinuities. They are specifically designed to homogenize the indirect lighting generated by their projection on hard to scan surfaces. The downside of these patterns is that matching projected and captured images is not straightforward anymore. A probabilistic correspondence method is formulated to solve this problem efficiently. Another important aspect of reconstruction obtained with unstructured light patterns is their ability to recover subpixel correspondences, that is with a precision finer than the pixel level. We present a method to produce long codes using unstructured light. These codes enable us to extract more precise correspondences while requiring less patterns. This contribution makes our method one of the most accurate yet robust to standard challenges method of active reconstruction in the domain. Finally, the last part of this thesis adresses the comparison of existing reconstruction methods on several aspects, but mainly on the impact of using less and less patterns on the quality of the reconstruction. While some methods need a fixed number of images, some, like ours, can accommodate fewer patterns in exchange for some quality loss. We devise a simple method to capture an optimal correspondence map that can be used as a groundtruth for comparison purposes. Last, we present several hybrid methods that perform quite well even with few images. Keywords— 3D vision, computer vision, active reconstruction, coded light, structured light, unstructured light, projector, camera


The negative impacts that scientific monitoring may have on marine ecosystems has been a neglected topic, mainly on the basis that its magnitude is minor compared to commercial fisheries, even though this raises ethical and, in certain cases, conservation issues. We argue that ethical principles should lead us to reconsider marine wildlife resource monitoring such as the fish and shellfish trawl surveys providing the science-based evidence needed for fisheries management and assessment of how environmental change affects marine shelf communities worldwide. Recent scientific and technological progress has provided methods and tools which might now be harnessed to reduce the impact of marine monitoring. We review these alternative methods, consider modifications to current practices and identify areas requiring further research.


Objective To study the relationship between red blood cell distribution width(RDW)and thyroid associated ophthalmopathy(TAO).Methods Fifty-two patients with Graves' disease(GD,18 males and 34 females,39cases of GD patients with Graves' ophthalmopathy[GO])and 22 healthy controls(8 males and 14females)were recruited in the present study.The RDW and thyroid functions were measured in all participants.Ophthalmological examinations including Hertel's exophthalmometer readings(HER)and clinical activity score(CAS)evaluation were obtained in GD patients,and the results were compared between different groups.Results Thyroid functions were significantly different between GD patients and healthy controls(P0.05),while they were not between GD patients with or without GO;the HER level was significantly higher in those with GO compared with those without GO(P0.05).The RDW value in patients with GD was significantly higher than that in the healthy controls(P0.05).For GD patients,RDW increased with the increase of CAS,and those with GO had significantly higher RDW than those without GO(P0.05).Conclusion RDW is associated with the state of the GD patients,indicating that RDW may provide evidence for assessing the severity of GO.


A 2.45 GHz electron cyclotron resonance (ECT) ion source, recently developed at Chalk River, a was installed on the RFQ1 (radiofrequency quadrupole-1) facility for comparison with the duoPIGatron source used previously. The proton fraction of the ECR ion source is 80 to 85% much higher than the 30 to 35% of the duoPIGatron. Measurements of the beam transmission through the RFQ, as well as the emittance of the extracted and the accelerated beams, are reported. Four-aperture extraction columns were used on both sources.<<ETX>>


A brief review of recent literature on riser design is presented and a concise description of the design process is given. Effects of hydrodynamical design parameters on marine flexible riser design are then reviewed. Riser dynamic analyses are described which substantiate design criteria for the selection of riser configuration in deep and shallow water. The results of dynamic analyses using computerized numerical models are presented in this paper in graphical form for the selected riser design cases. Output includes envelopes of riser coordinates, axial force and time histories of forces and wave surface profiles. The results obtained highlight the significance of motion spatial gradients for the combined flow of waves, currents and vessel heave motion on the selection optimum of riser configuration to address design requirements.


Isomap borrows the idea of geodesics which is from differential geometry, hoping data can keep geodesic distance on the manifold after transforming into low dimensional space mapping. Isomap takes advantage of Gradient descent or Stochastic gradient descent to solve the problem in the end. However, Isomap is prone to get trapped in local minimum, and the result obtained is always a local optimal solution. In order to solving such kind of problem, this article comes up with Cuckoo search to optimize the solutions about figuring out manifold distance.


A technique to generate ultrasonic waves in graphite‐epoxy composite structures using electrical current pulses flowing in the structure is described. The difference between the thermal expansion coefficients of graphite and epoxy create large stress waves in response to localized heating by current pulses flowing in the individual graphite fibers. Experimental results are presented demonstrating the applicability of the method to nondestructive testing problems. The anisotropic elastic and electrical properties of a T‐300 graphite/DER‐332 epoxy composite plate were determined. In the experiments, a piezoelectric receiver transducer was used to detect the thermoelastic waves in the composite plate. Distinct ultrasonic waves were detected with 20 μsec current pulses below 50 mA.


The flexural impact behavior of concrete beams which reinforced with HPP, steel fiber and these two fibers is studied. The initial-crack, fracture impact cycle number and impact energy of these concrete beams with different fiber dosage are also tested. The results show that the impact energy and the toughness of the concrete with hybrid fibers are more enhanced than those with single kind of fiber but the initial-crack capability of the concrete has been affected a little.


We report microstructural characteristics and properties of gallium-doped ZnO films deposited on glass by pulsed laser deposition. The Zn0.95Ga0.05O film deposited at 200 °C and 1×10−3 Torr showed predominant ⟨0001⟩ orientation with a metallic behavior and a resistivity of 2×10−4 Ω cm at room temperature. Low resistivity of the ZnGaO films has been explained in terms of optimal combination of carrier concentration and minimized scattering, and is correlated with the microstructure and the deposition parameters. Power conversion efficiency comparable to indium tin oxide-based devices (1.25±0.05%) is achieved on a Zn0.95Ga0.05O∕Cu-phthalocyanine∕C60 double-heterojunction solar cell.


The following interview with Edward Bond took place in the summerhouse located in the garden of his cottage in rural Cambridgeshire some years ago. During the interview I was overwhelmed by the author's extraordinary personality and humanity; he spoke so extensively, with great seriousness, conviction and concentration, that I hardly dared to interrupt his powerful torrent of thoughts to pose my questions.


How often have you heard the 'I hate shift work' blues? Or even sung them yourself'' Well, here's an alternative view: I love working shifts and in many ways I think it can be good for you.


Studies on amphibians of permanent water bodies and marshes in the Wawer district of Warsaw were carried out in the spring of 2007. This terrain is situated on the right bank of the Vistula River, an d is one of the least urbanized areas of the city. In this study, species composition, frequency of occurrence and number of individuals on breeding sites were determined. Surprisingly, only six amphibian species were found, which was two times lower than found during previous research in the left bank are a of Warsaw. The most common species occurring in Wawer were: moor frog ( Rana arvalis ) and common toad ( Bufo bufo ). Only 69.2 % of permanent water bodies were inhabited by any amphibian species. To enable future comparative studies to be made on the impact of urban developm ent and increased human activity on local amphibian populations, the precise locality of breeding sites were p rovided.


Latent infections produced by Monilinia fructicola on green apricot fruit are separated from aqueous contact with live host tissues by hydrophobic suberin. However, they respond to host ripening and become invasive. The time and intensity of production of the volatile compounds acetaldehyde and ethanol during fruit ripening strongly correlated with both the invasive outbreak of mycelium from arrested lesions, and with the stimulation of growth of germ tubes in vitro in the presence of fruit volatiles. Latent infections on green apricots were activated to escape from the lesions in response to exposure to those volatiles in the concentration detected from ripe apricots. However, the tissue of green apricots was stimulated to fresh necrosis and general fruit invasion did not occur.


Legg‐Calvé‐Perthes disease (LCPD) is a childhood hip disorder of ischemic osteonecrosis of the femoral head. Hip joint synovitis is a common feature of LCPD, but the nature and pathophysiology of the synovitis remain unknown. The purpose of this study was to determine the chronicity of the synovitis and the inflammatory cytokines present in the synovial fluid at an active stage of LCPD. Serial MRI was performed on 28 patients. T2‐weighted and gadolinium‐enhanced MR images were used to assess synovial effusion and synovial enhancement (hyperemia) over time. A multiple‐cytokine assay was used to determine the levels of 27 inflammatory cytokines and related factors present in the synovial fluid from 13 patients. MRI analysis showed fold increases of 5.0 ± 3.3 and 3.1 ± 2.1 in the synovial fluid volume in the affected hip compared to the unaffected hip at the initial and the last follow‐up MRI, respectively. The mean duration between the initial and the last MRI was 17.7 ± 8.3 months. The volume of enhanced synovium on the contrast MRI was increased 16.5 ± 8.5 fold and 6.3 ± 5.6 fold in the affected hip compared to the unaffected hip at the initial MRI and the last follow‐up MRI, respectively. In the synovial fluid of the affected hips, IL‐6 protein levels were significantly increased (LCPD: 509 ± 519 pg/mL, non‐LCPD: 19 ± 22 pg/mL; p = 0.0005) on the multi‐cytokine assay. Interestingly, IL‐1β and TNF‐α levels were not elevated. In the active stage of LCPD, chronic hip synovitis and significant elevation of IL‐6 are produced in the synovial fluid. Further studies are warranted to investigate the role of IL‐6 on the pathophysiology of synovitis in LCPD and how it affects bone healing. © 2015 American Society for Bone and Mineral Research


With the rapid development of Internet and the start of Goverment Online Project,the in-teraction between citizen and government must be highly concerned.Internet will break the government's monoply on information;It will improve technological means of citizen participation in politics;It will also provide government with new runction of protecting information privacy and breaking monopoly on. In this way,the rights of citizens will be better protected.


Objective To analyze the difference in the coagulation function between normal pregnant women in the third trimester and patients with hypertensive disorders in pregnancy,and investigate the relationship among coagulation-related parameters,severity of disease and gestational age. Methods The blood samples were collected from 140 normal pregnant women in the third trimester and 76 pregnant women with hypertensive disorders.Platelet(PLT),mean platelet volume(MPV),prothrombin time(PT),partial thromboplastin time(APTT),fibrinogen(FIB),D-dimmer(D-D),prothrombin fragment 1+2(F1+2) and thromboxane B2(TXB2) were measured. Results ①Compared with the normal pregnant women in third trimester,the level of PLT,PT,APTT and FIB in the pregnant women with hypertensive disorderswere significantly decreased(P0.05 or P0.01),while that of MPV,D-D,F1+2 and TXB2 were significantly increased(P0.01).②The level of FIB was significantly lower in severe preeclampsia(n=53)than in mild preeclampsia(n=23),whereas that of D-D,F1+2 and TXB2 were significantly increased(P0.01).③The level of PT and FIB was lower and TXB2 was higher in early onset preeclampsia(n=40) than in late onset preeclampsia(n=36)(P0.05).The level of D-D and F1+2 were increased in early onset preeclampsia than in late onset preeclampsia(P0.01).Conclusion There are hypercoagulative state in pregnant women with hypertensive disorders.FIB,D-D,F1+2 and TXB2 may be used as sensitive indexes in the diagnosis and severity evaluation of hypercoagulative state of hypertensive disorders in pregnancy.The disorders of coagulation function may be more severe in early onset preeclampsia than in late onset preeclampsia.


The main objective of this study was to determine the feasibility and efficacy of a social media-based nutrition intervention using Twitter on nutrition knowledge, dietary practices, body mass index, self-efficacy, and social support among student-athletes. Participants included 50 male and female NCAA Division I student-athletes between the ages of 18-24 years old. Data were collected in October 2014. The study design employed a six-week, social media intervention using Twitter©, to increase nutrition knowledge, self-efficacy, social support and dietary adherence to the Dietary Guidelines for Americans recommendations. Descriptive statistics were calculated for all study variables and pre-post differences were assessed using paired t-tests. The results indicate a 6-week nutrition intervention delivered solely through social media resulted in increased nutrition knowledge (t=-2.23; p=0.035), reduced fat intake (t=- 1.57; p=0.13) and decreased BMI (t=2.32; p=0.027) in student athletes. In conclusion, social-media based nutrition education may provide university-based strength and conditioning coaches and other sports practitioners with a tool for widespread and timely access to students in order to facilitate healthy dietary behaviors.


Career & College Preparation (CCP) courses lead to a high school diploma, or Dogwood Certificate, and to prerequisites for post-secondary programs, and to upgrading skills for the workplace.


The increase in human population has resulted in environmental alterations and habitat fragmentation, such as those caused by road construction. Since the late 1990s, there has been an increase in studies evaluating the effects of roads on vertebrate populations; however, few studies have considered bats in road ecology studies. In this review on road ecology studies focusing on bats, we evaluated the impacts of roads on bat mortality, commuting, and foraging. We also evaluated the use of road structures as roosts and provide suggestions for future research and mitigation methods based on available results. Road impacts on bat activity and roadkill are strongly influenced by landscape features, and areas with short trees have more impact on roadkill. Also, in open areas, bats prefer to forage near roads whereas in woodland areas activity increases with distance from the road. Most studies evaluating the effects of roads on bats have been conducted in Europe, therefore it is essential that these studies are conducted in other areas, especially in developing countries. To ensure the conservation of bat species, it is imperative that studies consider all impacts that roads have on bat populations and that mitigation measures are applied, especially when road construction meets bat commuting or foraging paths.


The gel sodium alginate as carrier was used to immobilize laccase from Agaricus bisporus,optimizing immobilization conditions and study the character of the immobilized enzyme and its application value in deccolorization.The result showed that best immobilization conditions was alginate 10 g/L,CaCl2 0.25 mol/L,the volume ration of laccase with alginate was the best reacting temperature and saving temperature of the immobilized enzyme were same with the free enzyme.But,the reaction range of the temperature was wider.The thermal stability was also increased.Compared with free enzyme,the immobilized enzyme can adapt to more acidic and alkaline environment.The reaction with eight commercal dyes showed that four dyes can be obviously degraded by the laccase.The decolorization rate of the weak acid brilliant blue RAWL can reach 64.7%.The immobilized laccse from Agaricus bisporus optimized the enzymatic properties,so the immobilized enzyme had a certain industrial applications.


With the rapid development of remote sensing technology,it needs higher requirement when people interpret the surface features to the resolution of remote sensing data. This paper uses three different image fusion techniques in the study area of the ETM + remote sensing data which makes double improvement of the spatial resolution,and carries out a comparative study of three methods,draws some useful conclusions.


A pushrod-type wafer holder apparatus using a cylinder for reciprocation. The apparatus consists of a tray, a fixed clamp, a protruding support, a movable apparatus, and a cylinder. By executing a control unit command, the cylinder actuates a sliding block into a linear reciprocation. The sliding block drives a flexible element and a mobile clamp into a synchronized motion, clamping a wafer between the fixed clamp and the mobile clamp, thus restricting the degrees of freedom of the wafer in the horizontal and vertical directions. Distension of the flexible element exerts a certain pressure on the rim of the wafer. This allows for the water to be fixed securely and for transport in any direction, thus solving the problem of transport direction singularness. Adjustments in the position of the protruding support and in the moving distance of the sliding block allow for transport of wafers of different diameters, solving the problem of singularness in the size of wafers being transported. The flexible element is used to improve the flexibility of the apparatus, thus preventing damages to the wafer caused by deviation in the moving distance when clamping the wafer.


The symmetric function class interacts heavily with other types of functions. One of these is the convex function class, which is strongly related to symmetry theory. In this study, we define a novel class of convex mappings on planes using a fuzzy inclusion relation, known as coordinated up and down convex fuzzy-number-valued mapping. Several new definitions are introduced by placing some moderate restrictions on the notion of coordinated up and down convex fuzzy-number-valued mapping. Other uncommon examples are also described using these definitions, which can be viewed as applications of the new outcomes. Moreover, Hermite–Hadamard–Fejér inequalities are acquired via fuzzy double Aumann integrals, and the validation of these outcomes is discussed with the help of nontrivial examples and suitable choices of coordinated up and down convex fuzzy-number-valued mappings.


This paper is dedicated to the investigation of a new numerical method to approximate the optimal stopping problem for a discrete-time continuous state space Markov chain under partial observations. It is based on a two-step discretization procedure based on optimal quantization. First,we discretize the state space of the unobserved variable by quantizing an underlying reference measure. Then we jointly discretize the resulting approximate filter and the observation process. We obtain a fully computable approximation of the value function with explicit error bounds for its convergence towards the true value fonction.


In this article, we present a new unified finite element method (UFEM) for simulation of general Fluid-Structure interaction (FSI) which has the same generality and robustness as monolithic methods but is significantly more computationally efficient and easier to implement. Our proposed approach has similarities with classical immersed finite element methods (IFEMs), by approximating a single velocity and pressure field in the entire domain (i.e. occupied by fluid and solid) on a single mesh, but differs by treating the corrections due to the solid deformation on the left-hand side of the modified fluid flow equations (i.e. implicitly). The method is described in detail, followed by the presentation of multiple computational examples in order to validate it across a wide range of fluid and solid parameters and interactions.


To select efficient entomopathogenic fungal strains of Lecanicillium for the biocontrol of aphid, Myzus persicae, conidial suspension () was sprayed onto a detached Chinese cabbage leaf in a petri dish with a dampened filter paper that had 20 nymphs of aphid. Lecancillium strain 4078 and 6543 were the best strains for the biocontrol of aphid at high temperature of and low relative humidity (RH) of 85%, respectively. The cumulative mortality of strain 4078 at after 3 days was 100% and that of strain 6543 was 90% at 85% RH after 5 days. Strain 4078 also exhibited almost 100% germination ratio of conidia and high rate of mycelial growth at the broad temperature-range of . The strain 4078 and 6543 were all identified as Lecanicillium species based on the DNA sequences (accession no.: EF026004 and EF026005, respectively) of the ITS regions of the fungi. Excellent production of aerial conidia of strain 6543 was accomplished by using steamed polished rice as the solid culture medium.


ABSTRACT In this essay, the author attempts to describe how the pressures of the crisis and the trauma created by the war in Ukraine have reshaped and transformed both her identity as a dynamic psychotherapist and her typical relationship with her patients. As both therapists and patients are grappling with their own safety and their contribution to the war effort, the therapeutic neutrality and anonymity the author had been trained to maintain are now making no sense. Through dramatic clinical vignettes illustrating these struggles, the author describes how certain feelings abound, guilt and shame for those who flee for the safety of other countries, and anger, envy and resentment for those who are left behind, and how these feelings are being played out in the therapeutic relationships. Ethical dilemma forces her to abandon her neutral stance with some patients and contribute to reshape her own sense of professional identity. In the end, through intense and anxious questioning, the search for human connection in the face of horrors seem to survive and support both patients and therapists.


Abstract Some bemoan the incivility of our times, while others complain that people have grown too quick to take offense. There is widespread disagreement about what counts as an insult and when it is appropriate to feel insulted. Here I propose a definition and a preliminary taxonomy of insults. Namely, I define insults as expressions of a lack of due regard. And I categorize insults by whether they are intended or unintended, acts or omissions, and whether they cause offense or not. Unintended insults are of particular concern since greater understanding may help us to avoid them. And insults by omission warrant special consideration because they suggest an interesting extension of Grice's theory of conversational implicature.


To investigate the fragmentation mechanism of fluroquinolones,six compounds of fluroquinolones were analyzed using electrospray ion trap mass spectrometry by collision induced dissociation in a multi-stage MS full scan mode.The samples were infused into the ion source with a syringe pump and the mass spectrometry was operated in the positive mode.The mass spectra and structures of the six fluroquinolones were compared with each other and it was observed that fluroquinolones gave characteristic fragment ions by the neutral loss of CO_2,HF and CO,corresponding to the carboxy,fluorine and 4-carbonyl group in their structures.There would be another fragment ions by the elimination of CH_2=CH-NH_2 if the structure was with a 7-piperazidine substituent.These characteristics can be used for future structure elucidation in studies of fluroquinolones and analogue compounds.


Froth flotation is an important mineral concentration technique. Fault conditions in flotation processes will hugely cause the waste of mineral resources and chemical reagents, and further cause the decline of concentrator's benefit. This paper proposes a framework for computer vision aided fault detection and diagnosis for froth flotation. The framework seeks to address (1) the froth image representation problem using copula model based on Gabor wavelets; (2) the fault detection using isolation forest, and training sets that have an overwhelming majority of normal instance and few fault instances will be produced using rejection sampling technique; (3) the root cause identification problem using XGBoost classifier. The whole framework is developed for froth flotation fault diagnosis and tested in a lead-zinc flotation plant in Shaoguan, P.R. China. Experimental results show that 1) the copula joint texture has better performance than others froth image features; 2) the training set generated from the distribution of flotation working condition using rejection sampling can further improve the fault detection performance of isolation forest.


The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging; mice lacking ribosomal protein S6 kinase 1 (S6K1−/−) have extended lifespan and healthspan relative to wild type (WT) controls. Exactly how reduced mTOR signalling induces such effects is unclear, although preservation of stem cell function may be important. We show, using gene expression analyses, that there was a reduction in expression of cell cycle genes in young (12 week) and aged (80 week) S6K1−/− BM-derived c-Kit+ cells when compared to age-matched WT mice, suggesting that these cells are more quiescent in S6K1−/− mice. In addition, we investigated hematopoietic stem cell (HSC) frequency and function in young and aged S6K1−/− and WT mice. Young, but not aged, S6K1−/− mice had more LSK (lineage−, c-Kit+, Sca-1+) cells (% of bone marrow (BM)), including the most primitive long-term repopulating HSCs (LT-HSC) relative to WT controls. Donor-derived engraftment of LT-HSCs in recipient mice was unaffected by genotype in young mice, but was enhanced in transplants using LT-HSCs derived from aged S6K1−/− mice. Our results are the first to provide evidence that age-associated HSC functional decline is ameliorated in a long-lived mTOR mutant mouse.


A new round of teaching reform in the primary curriculum is being promoted all over the country. Researchbased learning gradually becomes a new pattern in the teaching of junior biology. Therefore, this paper aims to study its connotation, its characteristics and the principles to implement it. Key wods: junior biology;curriculum reform;researchbased learning


This article is devoted to the formation of national pride in preschool-aged children through acquaintance with historical monuments. The pedagogical knowledge and skills of educators on the formation of elements of national pride in children are not sufficient to provide the necessary pedagogical conditions for the formation of the qualities that are planned to be formed in children. The study of the situation in practice also shows that the work aimed at building elements of national pride in preschool education institutions is not carried out systematically.


A structural health monitoring system that aims to extract local damage information (i.e., existence, location and severity) in buildings may require a dense array of transducers due to the high complexity and high degree of statical indeterminacy of their structural system. While monitoring systems for building applications are mostly consisted of seismographs or tremor sensors, a technique to pragmatically and accurately capture strain information of structural members is efficacious for detecting damage in individual members. This paper presents the use of polyvinylidene fluoride piezoelectric films as dynamic strain sensors for detecting local damage in steel moment-resisting frames. First, a damage detection methodology that monitors the changes in the relative distribution of the bending moments in structural systems is presented. Next, an array of dynamic strain sensors networked by wireless sensing units is developed in consideration of its installation cost and efforts when it is applied to real buildings. Finally, the performances of the developed methodology and its sensing system are evaluated through a series of vibration testing using a 5-story steel testbed frame that can simulate seismic damage at beam-to-column connections.


This article explores the use of participatory photography in ethnographic research with hunter-gatherer children. Drawing on my fieldwork in Peruvian Amazonia, I examine on how participatory photography can help researchers of childhood to move beyond the notion of child voice and explore non-verbal realms of knowledge from a child-centred perspective. While acknowledging the drawbacks and limits of child-centred visual methods, I will focus primarily on the advantages of using methodologies that can highly stimulate children's enthusiasm and participation in the research process, allowing the researchers to move away from an adult-centric research approach.


Thyroid carcinoma is the most common malignant tumor in the endocrine diseases, with a rising morbidity. As more investigations were made, thyroid stimulating hormone receptor is showed up, and it is believed some contacts are existed between thyroid stimulating hormone receptor and thyroid carcinoma. We believe that making sure of these contacts can help patients in diagnosis, treatment, and prognosis.

Key words:
Thyroid carcima; Thyroid stimulating hormone recptor


Social networking service (SNS) refers to an online service established for the purpose of sharing specific interests or activities by forming social relationships based on a wide human network online.1 The use of SNS is rapidly increasing among all generations, and the use rate of university students (95.9%) is the highest.2 The university student period emphasizes social relationships and has the developmental task of forming close interpersonal relationships.3 The active use of SNS by university students can be understood as a natural phenomenon in that the use of SNS can help form close interPrint ISSN 1738-3684 / On-line ISSN 1976-3026 OPEN ACCESS


Increasing the number of circuit elements according to the present invention can be prevented by increasing the number of rows caused by buffers, the processing time can be shortened and the write line buffer. In the display control circuit 2 inputs the input picture data from the display memory b, b is input to the transmission control and priority control circuit 12 at one end. In another end of the circuit 12, the input picture data stored in the line buffer 13 in g, and for controlling the transmission priority order control screen data b and g, the output of the picture data inputted to the line buffer 13 f. And the transmission priority order control end time data stored in the line buffer 13 in synchronization with the monitor signal d is output as picture data.


The European Regulation No 443/2009 puts high pressure on the future market for passenger cars in Europe. The average target of 95 gr. of CO2 emissions per km in 2020 for the new registrations is challenging and seems to be hardly achievable with business as usual measures. Electric vehicles (EV) are said to be an efficient technology to reduce CO2 emissions. This hypothesis is strongly connected to the uncertainties of the market penetration of EV and the underlying actual energy mix of electricity generation during the charging process. Therefore, we first simulate the individual German road transport sector until 2030 with regard to the annual mileage of the vehicles with the mesoeconomic multi agent based model COMIT. We substantially updated the integrated vehicle demand module of COMIT and strengthened the technology decision approach. We developed two scenarios in order to take the high uncertainty about the vehicles purchase decision in the future into account. Then, using the calculated market penetration of 1.43 million (6 million) EV in 2030, we identify the mix of electricity to satisfy the corresponding additional electricity demand of 2.12 TWh (8.5 TWh) in consideration of the charging time (instantaneous charging). Furthermore, we use the cost optimizing energy system model PERSEUS-NET to compare the resulting electricity mix and the CO2 emissions of the energy sector with and without EV. The hypothesis that EV are an efficient technology to reduce greenhouse gases is mainly based on two uncertainties: (1) The market penetration is unclear and (2) the specific emission reductions do highly depend on the underlying actual energy mix of electricity generation during the charging process. Therefore, we focus on the market penetration by the COMIT model and on the electricity mix by the PERSEUS model.


Thanks to the full play of the synergy of local node sets, fog Internet of Things (IoT) technology has become the focus of many researchers. Unfortunately, the data transmission of the sensing terminal therein has the risk of being eavesdropped, due to the openness of the wireless channel and the large-scale deployment of different types of terminals. Meanwhile, the encryption method based on cryptography is difficult to apply to the IoT terminals with limited capacity because of its high-computational complexity. This article considers the use of physical layer security technology where the fog node improves the secrecy capacity of the desired channel by sending artificial noise to the untrusted third party to ensure the reliable transmission of data. Specifically, an intelligent resource allocation method based on deep reinforcement learning (DRL) is proposed to realize the rapid allocation of link resources and interference noise power in the scene, where the relevant elements, such as state, action, and reward, are reasonably designed. Simulation results demonstrate that the presented algorithm could effectively resolves the allocation problem, and its transmission delay obviously outperforms that of multiple comparison methods.


acknowledgements vii editor's introduction 1 {ensp}1 aurelio bernardi The Economic Problems of the Roman Empire at the Time of its Decline 16 {ensp}2 m. i. finley Manpower and the Fall of Rome 84 {ensp}3 charles diehl The Economic Decay of Byzantium 92 {ensp}4 bernard lewis The Arabs in Eclipse 102 {ensp}5 jaime vicens vives The Decline of Spain in the Seventeenth Century 121 {ensp}6 J. H. ELLIOTT The Decline of Spain 168 {ensp}7 carlo m. cipolla The Economic Decline of Italy 196 {ensp}8 bernard lewis Some Reflections on the Decline of the Ottoman Empire 215 {ensp}9 c. r. boxer The Dutch Economic Decline 235 10 ping-ti-ho Economic and Institutional Factors in the Decline of the Chinese Empire 264 appendix 278 bibliography 279


Collective cell migration is critical for normal development, wound healing, and in tumor progression and metastasis. Border cells in the Drosophila ovary provide a genetically tractable model to identify molecular mechanisms that drive this important cell behavior. In an unbiased screen for defects in border cell migration in mosaic clones, we identified a mutation in the catsup gene. Catsup, the Drosophila ortholog of Zip7, is a large, multifunctional, transmembrane protein of the endoplasmic reticulum (ER), which has been reported to negatively regulate catecholamine biosynthesis, to regulate Notch signaling, to function as a zinc transporter, and to limit ER stress. Here we report that catsup knockdown caused ER stress in border cells and that ectopic induction of ER stress was sufficient to block migration. Notch and EGFR trafficking were also disrupted. Wild type Catsup rescued the migration defect but point mutations known to disrupt the zinc ion transport of Zip7 did not. We conclude that migrating cells are particularly susceptible to defects in zinc transport and ER homeostasis.


We introduce a hierarchical approach for hardware-aided texture compression. The hierarchical representation is combined with a block-wise approach that is used in some existing texture compression techniques. Our method is an attempt to merge texture compression and mip-mapping.


[Standing up for the neighbourhood. Youth, exclusion and dreams for the future] Drawing on discourse psychology as analytical approach, Magnus Dahlstedt and James Frempong's article draws attention to youth living in the "Area", a stigmatized suburban area in Sweden. The aim is to investigate the ways in which the youth interpret their existence and create their identity in the Area, in relation to the expectations and interpretations of the surrounding society – about them as well as the Area. The analysis shows that youth talk about their existence in the Area in contrast to dominant discourses on suburban areas in the surrounding society. For the youth, the Area appears as a place where they feel at home. When they talk about the future, it is mainly individual scenarios directed at the Area that appears, while there is an absence of scenarios based on collective action directed towards the outside world. Thus, according to such reasoning, for change to be possible, the youth have to take responsibility and stand up for themselves. Publication history: Published original. (Published 28 May 2018) Citation: Dahlstedt, Magnus & James Frempong (2018) "Sta upp for orten. Ungdomar, utanforskap och forortsdrommar", in Platskamp , special issue of Arkiv. Tidskrift for samhallsanalys , issue 9, pp. 27–51. DOI: https://doi.org/10.13068/2000-6217.9.1


Abstract In this article, a study of Finite Memory Observers on an unknown input system is treated using augmented states. In this study noised system is processed and especially state noise due to the modelling of the system with unknown input. After giving a mathematical overview on unknown input observers and after writing Finite Memory Observers principles, results are given according to fault indicators and especially in fault indicator tables.


The paper describes a sparse direct solver for the linear systems that arise from the discretization of an elliptic PDE on a two dimensional domain. The solver is designed to reduce communication costs and perform well on GPUs; it uses a two-level framework, which is easier to implement and optimize than traditional multi-frontal schemes based on hierarchical nested dissection orderings. The scheme decomposes the domain into thin subdomains, or"slabs". Within each slab, a local factorization is executed that exploits the geometry of the local domain. A global factorization is then obtained through the LU factorization of a block-tridiagonal reduced coefficient matrix. The solver has complexity $O(N^{5/3})$ for the factorization step, and $O(N^{7/6})$ for each solve once the factorization is completed. The solver described is compatible with a range of different local discretizations, and numerical experiments demonstrate its performance for regular discretizations of rectangular and curved geometries. The technique becomes particularly efficient when combined with very high-order convergent multi-domain spectral collocation schemes. With this discretization, a Helmholtz problem on a domain of size $1000 \lambda \times 1000 \lambda$ (for which $N=100 \mbox{M}$) is solved in 15 minutes to 6 correct digits on a high-powered desktop with GPU acceleration.


Diabetic neuropathy leads to postural instability. This study compared longitudinal changes in neuropathy outcomes relative to long‐term glycemic control in patients aged <60 years with uncontrolled type 2 diabetes with and without a short one‐leg standing time (OLST <60 s).


The theme of my work are the eating disorders and prevention. They are socially pathological phenomenon and are closely related to the field of social education science. The theoretical part is focused on nutrition and its importance for the organism, the history and definition of eating disorders. I focus on the main representative of anorexia nervosa and bulimia nervosa, their causes, the negative effects, treatment options and prevention. The empirical part contains information obtained by using qualitative research strategy. The work provides information about findings and recommendations for social educational practice in this area.


Since aging is associated with physical, cognitive, and social limitations that affect functional capacity of individual, alternative housing options were sought by many researchers as well as housing industry. Barrier Free housing features can help older adults to cope with consequences of aging and to live more independently in their housing. The purpose of this study is to evaluate the preference of young adults and the elderly for accessible housing attributes in their housing choice by using conjoint method, whereby respondents ranked a specific combination of particular accessible features. Based on literature reviews, accessible attributes were identified and used for analysis. The accessible attributes are clear width, removal of level difference, vertical accessibility, grab bars, non-slippery floor materials, alarm device, controller for service, and cost. The result indicated how important each accessible attribute is according to individual differences including age, income, housing type, and ownership. The most apparent difference in preference between the younger and the elderly was cost aspects in associated with accessible features. Regardless of age, income, and housing type, the respondents rated cost more important in their housing choice decision compared to the other accessible features. The conjoint analysis revealed that accessible housing attributes were related to the socio-economic variables of residents and housing type. For a single house type, vertical accessibility (e.g. elevator installation) is important. The combination of accessible attributes of housing ranked by residents was suggested.


Dielectric channel waveguide lasers are of great interest because of their low pump thresholds and, even more so, high slope efficiencies resulting from the excellent overlap between pump and laser modes and the small transverse channel cross-sections which reduce the volume of active medium that needs to be pumped. Slope efficiencies up to 75% in a femtosecond-written YAG:Yb3+ channel waveguide with an output power of 800 mW [1], 76% in a LiYF4:Tm3+ planar waveguide with an output power of 560 mW [2], as well as 70% and 76% in Tm3+ - and Yb3+ -doped potassium double tungstate channel waveguides with output powers of 300 mW [3] and 650 mW [4], respectively, are state of the art.


Cyanogenesis in Galegeae, Genisteae, Loteae and Phaseoleae, four tribes of Leguminosae-Papilionoideae, is discussed thoroughly. Oxytropis campestris (Galegeae) is shown to be facultatively cyanogenic (table I); cyanophoric plants contain a zierin-like glucoside. Lotononis crumaniana (Genisteae) is strongly cyanogenic and contains prunasin. Lotaustralin, accompanied by up to 5% Linamarin was demonstrated to be present in three taxa belonging to Dorycnium pentaphyllum sensu lato (table I). Leaves and stems of Phaseolus lunatus contain linamarin and perhaps trace amounts of lot-australin, but no taxiphyllin- or dhurrin-type glucosides.


Theoretical basis of applying top air analytic technique to geochemical logging is that the composition and content of light hydrocarbons in top air can reveal the nature and features of oil and gas reservoirs.Based on the relevant theories,the following features of light hydrocarbon composition of top air in gas condensate reservoirs are obtained through specific experiments:the value of C1/nC4 is small,while the value of Wh is very large [Wh =100×(C2+C3+C4+C5)/(C1+C2+C3+C4+C5)];the vaule of Bh is very small [Bh=(C1+C2)/(C3+C4+C5)],in contrast the value of Ch is relatively large [Ch=(C4+C5)/C3].A prominent feature is that the concentrations of light hydrocarbons do not decrease according to the composition sequence from C1 to C7,in contrast,the concentrations of some components after C1 or C2 may increase abruptly.Data of two wells are presented to exemplify these understandings.


Absorption and scattering in aqueous media would attenuate light and make imaging difficult. Therefore, an artificial light source is usually utilized to assist imaging in the deep ocean. However, the artificial light source typically alters the light conditions to a large extent, resulting in the non-uniform illumination of images. To solve this problem, we propose a non-uniform illumination correction algorithm based on a fully convolutional network for underwater images. The proposed algorithm model the original image as the addition of the ideal image and a non-uniform light layer. We replace the traditional pooling layer with dilated convolution to expand the receptive field and achieve higher accuracy in non-uniform illumination recognition. To improve the perception ability of the network effectively, the original image and parameters which pre-trained on the ImageNet are concentrated. The concentrated information is used as input to the network. Due to the color shift and blurred details of the underwater image, we design the novel loss function, which includes three parts of feature loss, smooth loss, and adversarial loss. Moreover, we built a dataset of the underwater image with non-uniform illumination. Experiments show that our method performs better in subjective assessment and objective assessment than some traditional methods.


We present a discrete theory for modeling developable surfaces as quadrilateral meshes satisfying simple angle constraints. The basis of our model is a lesser-known characterization of developable surfaces as manifolds that can be parameterized through orthogonal geodesics. Our model is simple and local, and, unlike in previous works, it does not directly encode the surface rulings. This allows us to model continuous deformations of discrete developable surfaces independently of their decomposition into torsal and planar patches or the surface topology. We prove and experimentally demonstrate strong ties to smooth developable surfaces, including a theorem stating that every sampling of the smooth counterpart satisfies our constraints up to second order. We further present an extension of our model that enables a local definition of discrete isometry. We demonstrate the effectiveness of our discrete model in a developable surface editing system, as well as computation of an isometric interpolation between isometric discrete developable shapes.


Abstrac t-The pas sive regional satellite navigation system (PRSNS) becomes a significant topic for civil and military services due to the limit of outlays and geography factors. The research on the modeling and simulation (M&S) of PRSNS is to study the key technology and operation principle. The paper discussed how to build up the simulation system of PRSNS. The system included satellite constellation, tracking station, data processing center (DPC), feeding station, users' application, information management, surveillance and visualization, etc. And the system is divided into two major logical parts and three physical layers to reduce the dependence among the components in order to quicken the programming process. As an example, a simulation system of PRSNS is constructed, which adopts a satellite constellation that is composed of geostationary earth orbit (GEO) satellites, inclined geosynchronous orbit (IGSO) satellites and median earth orbit (MEO) satellites and covers the Pacific-Asia, Indian Ocean and Middle East. The efficiency of the simulation system and the feasibility of PRSNS are verified by simulated static positioning and dynamic navigating.


The correlation between a number of biochemical factors of blood and coelomic fluid (sodium, potassium, magnesium, calcium, cholesterol, total protein and glucose) were determined as well as their relation with yolk sphere and perivitelline space in 80 female of the migratory population of Caspian Kutum in Tajan river of Iran in spring of the 2007. There was significant correlation between potassium of coelomic fluid with magnesium as well as the ratio of sodium to potassium of blood (P<0.05). On the other hand, there was a reverse correlation between potassium of coelomic fluid with blood glucose (P<0.05). There was significant correlation between blood sodium and magnesium of coelomic fluid (P<0.01); either was between blood magnesium and cholesterol of coelomic fluid (P<0.01). Correlation between blood calcium and pH of coelomic fluid, was reverse (P<0.05). With increasing in total protein of blood, the ratio of yolk sphere to perivitellin space significantly increased (P<0.01), but increasing perivitelline space decreased (P<0.05). There was a direct significant correlation between blood glucose and the ratio of yolk sphere to perivitellin space. A reverse correlation was existed between blood glucose and perivitelline. Although effects of blood on fish fertilization process is of great importance, there is less literature on this subject. The object of the following study was to investigate these correlations in Caspian Kutum.


Objective:To establish the average values of dental arch width and length,and to analyze morphological characteristic of the people with normal occlusion in Jiangsu district.Methods:125 normal occlusion models(61 Males,64 Females) wers scanned into computer and the widths and lengths of the dental arches were measured using software winchph 8.0.Results:The average values of arch widths and lengths of the normal occlusion in Jiangsu district refering to Currier outer curves were obtained.Widths and lengths of dental arches in males were larger than in females.Graphs of arch forms and beta function of normal occlusion in Jiangsu district were established.Conclusion:There're ethnic,regional and gender differences in arch forms.


Five mixes were investigated, three of them containing the whole fraction of flux either as potash feldspar "orthoclase" or soda feldspar "albite" from two different sources while the other two contained a mixture of both albite and orthoclase feldspar in the ratios 2:1 or 1:2., The mixes were formulated to study their effect on the different properties of sanitaryware. High albite mixes needed lower amounts of electrolyte than the orthoclase rich mixes. The potash felds par melt was formed attheeutectic temperature of 990 °C, which partially dissolved the quartz present as well as the mullite formed, minimizing its content. The late dissolution of albite feldspar at 1100 °C, on the other hand, caused the presence of mullite at a later stage than in the orthoclase feldspar. The increase in the proportion of orthoclase increased the amount of liquid phase, which increased the tendency to sagging. The MOR was negatively affected by the substitution of orthoclase for albite.


On 3 May 2018, the Centre for Strategic and Contemporary Research held a panel discussion at the Pakistan Institute for Parliamentary Services, Islamabad, titled 'Security Dynamics of Balochistan as a Determinant of Pakistan's Foreign Policy'. The purpose of the discussion was to determine the significance of Balochistan's internal dynamics for Pakistan's foreign policy decision making as well as for regional peace and security. The select audience consisted of policymakers, diplomatic representatives, academicians, students and the media.
Reproduced in this document is the transcript of the views of each of the panel discussants.


History of traditions and cultures of man in society and the religious achieves albeit gazettes through the ages have not only honoured man, but have ascribed to him superiority and priority of concerns in all matters of life endeavour. Incidentally, as his
power increases to effect control over his assets, which include his family, the agony of the (seemingly) marginalized woman is observed to increase, as the entire system operates in his favour. As tension increases over roles and responsibilities in the family, so do reactions and (or) prognostications. This is the background of this study, which features a unique feminist approach to the polemics of women domination and oppression. Here is Alkali's emerging perspective on what appears to be "the face of the new woman" presented in a
fresh light, hopeful, progress-oriented as she struggles for empowerment by means of self-development. This is in sharp contrast with the traditional, lamentative tales of women in
other Medias. This feature does not appear confrontational as is common with her compatriots in the gender battle of wits. African Research Review Vol. 1 (2) 2007: pp. 1-18


Circular RNAs(circRNAs) have been demonstrated to play significant biological roles in many human biological processes such as competing endogenous RNAs or miRNA sponges, regulating gene transcription, translating proteins and others. Inferring the functions of circRNAs is an important strategy for understanding disease pathogenesis at the molecular level. However, most circRNAs have not been functionally characterized. Developing effective computational approaches to identify potential functions of circRNA has become a hot topic. In this paper, we propose an integrated model, DKCirc2GO, to infer the gene ontology (GO) functions of circRNAs by integrating multiple data sources, including the expression profiles of circRNAs, circRNA-protein associations, protein-protein interactions (PPI), protein-GO associations, GO-GO semantic similarity. The C2P global network is constructed by integrating three heterogeneous networks: circRNA-circRNA similarity network, circRNA-protein association network and protein-protein interaction network. The P2G global network is constructed by integrating three heterogeneous networks: protein-protein interaction network, protein-GO association network and GO-GO semantic similarity network. The KATZ measure is then employed respectively to calculate similarities in the two global network. The circRNAs-protein-GO(cpg) association network is constructed based on the KATZ similarity scores. Finally, we annotate circRNAs with Gene Ontology (GO) terms of their neighboring protein-GO terms. The experimental results show that DKCirc2GO has a significantly better performance than existing state-of-the-art methods in terms of F-max.


The ongoing European economic crisis provides a focus for academics wishing to understand the relationship between major exogenous shocks and changes to environmental protection. Yet, measuring change, particularly to policies, is notoriously fraught with difficulties. This research note explores the conceptual and methodological challenges associated with capturing change in response to the economic crisis in Europe, specifically focusing upon the environment. The environment is typically touted as a European Union success story, but there is good reason to suspect that this policy sector may have been – and continues to be – negatively affected by the economic downturn. We suggest a toolkit of measures that can capture changes to this sector, and which may also be employed by researchers of other policy sectors.


Foreword Introduction French Women and America Nineteenth-Century Domesticity The Leisure Class Employment and Entrepreneurship Culture of Consumption Benevolence, Reform, Religion, and Politics Index


The invention discloses an OLED pixel compensation circuit and an OLED pixel driving method. The OLED pixel driving method comprises the steps as follows: S1, a reset process: a threshold compensation module clears a threshold voltage and a data voltage stored therein under the control of a second scanning end, and a first power supply charges a compensation capacitor; S2, a compensation process: a first scanning end makes the threshold compensation module receive a signal from a data signal end, the threshold compensation module observes the threshold voltage of a first transistor and uses the observed threshold voltage to compensate the data voltage, and the data voltage after compensation is stored in the compensation capacitor; and S3, a light-emitting display process: a light-emitting control end makes a load driving module receive a driving voltage output by the threshold compensation module, and a driving transistor converts the driving voltage into current for driving an organic light-emitting diode to drive the organic light-emitting diode to emit light. By adopting the method, the influence of change in power voltage of the pixel compensation circuit to the brightness of the organic light-emitting diode can be compensated.


An experimental technique using water extraction for evaluation of the content of ployethylene glycol of molecular weight 1,000 in wood where the ovendry weight of the untreated wood is not available was shown to be applicable for PEG-treated black oak and yellow-poplar.


National information policies for the Asia oceania region , National information policies for the Asia oceania region , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی


We have studied stimulated emission in rhodamine 6G - TiO2 random laser. The minimal threshold has been found at ultra-high concentrations of both dye and TiO2 nanoparticles.


We report characterization studies of Langmuir films and Langmuir−Blodgett multilayers of 13-cis-retinoic acid, 13-cis-retinal aldehyde, all-trans-retinoic acid, and all-trans-retinol palmitate. We have examined the stability of the floating monolayers prepared on an air−water interface, and the values estimated for the mean molecular areas before collapse are consistent with previous results for other retinal derivatives. After successful transference of the monolayers to form Langmuir−Blodgett films on different solid substrates, we have applied standard infrared spectroscopic techniques to investigate the structural organization of the deposited multilayers of the latter three compounds. By combining the information gathered from the isotherm compression curves of the Langmuir films to the analysis of the relative intensities of characteristic retinal peaks on the grazing angle and attenuated total reflectance spectra of the solid films, we have qualitatively estimated the orientation of the deposited ...


The implicit assumption in the modelling of fibre reinforced materials is that they are defect free. Defects in fibre-reinforced materials can be initated during their service life and can result a variety of damage phenomena. This paper focuses on the mathematical treatment of the case where a defect is present in the matrix of a uni-directionally reinforced composite but the fibres themselves exhibit continuity across the matrix crack. This results in a processes that is referred to as "flaw bridging". The amplification of the stress intensity factors at the boundary of the matrix crack can be influenced by the bridging action, to the extent that if the the fibres are inextensible, the stress intensity factor can be suppressed. This paper examines the flaw bridging action in a unidirectionally reinforced composite, which can be reduced to the solution of a Fredholm integral equation of the second kind. The mathematical treatment is used to examine the influence of the bridging action on the crack opening mode stress intensity factors at the boundary of a penny-shaped crack.


The purpose of this study was to evaluate the effect of a bio-modified binder on the performance and workability of asphalt mixtures designed with and without a high Reclaimed Asphalt Pavement (RAP) content. The bio-modified binder was prepared by modifying a virgin asphalt binder with bio-binder produced from swine manure. The four mixtures that were designed and evaluated were: a control mixture incorporating virgin materials, the control mixture incorporating 40% RAP, the control mixture incorporating the bio-modified binder and the control mixture incorporating the bio-modified binder and 40% RAP. The effect of the bio-modified binder on the stiffness and workability of the control mixture with and without RAP was evaluated by measuring the dynamic modulus and the torque resistance of the mixtures respectively. The performance of each mixture was evaluated for fatigue cracking (Overlay Tester) and moisture susceptibility/rutting potential (Hamburg Wheel Tracking Device). Finally, the degree of blending between the virgin and RAP binders was evaluated for each mixture. The data indicated that the addition of bio-modified binder helped reduce the stiffness of the control mixture with 40% RAP to a level closer to the stiffness of the same mixture without RAP. Correspondingly, the mixture workability for the control mixture with 40% RAP was improved. The data indicated that the bio-modified binder improved the cracking characteristics and had no negative effect on the moisture susceptibility/rutting characteristics of the control mixture with 40% RAP. Overall, data indicated that there was a good degree of blending between the virgin/bio-modified and RAP binders.


In this work Controlled Liquid Metal Cooling (CLMC) integrated in gravity investment casting process is evaluated in order to minimize the internal defects and subsequently improve the casting yield and mechanical properties. A356 was cast and cooled using conventional air cooling and controlled liquid metal cooling technique. Optical light stereo-microscopy, optical light microscopy, scanning electron microscopy equipped with energy dispersive x-ray scope and tensile tests were performed to investigate internal defects, microstructural features, grain sizes, shapes and performance. Microstructures of CLMC sample showed modified eutectic structure with spherical, dendritic primary alpha grains and reduced shrinkage porosity. Mechanical properties of CLMC are competitive to conventional air cooled samples.


OWl Gives General Prospecl To Americans ' on Home Fronl TICKLISH JOB NO. 11 CLEARING ENEMY MINE FIELDS u.s. B,)lribers .. Hit Jap ,Base Furore Over Pacific Confinue~asSfimson Pledges More Plan~s Roaring Eires Envelop Vilal Arms· (enler WASHINGTOl\' (AI') 'rho oniet) of WUl' iliforUlution Jast Jlight said American ciyilians tbis yeu,' face yurious shortage~ either occasionally !lOVOI'O 0 1' conLi n lIUUS ill U "serious food Damage 3 Convoy Vessels Approaching New Guinea Harbor MacArthur Assured Of Enough Aircraft To 'Counter' Enemy British Lose 23 Planes In 400-Mile Journey To Blast Motor Plants situulion. " .,. , Tho OWl ·1I.i<llhis is the gellOl'ul prospcct govel'lleu by many fucto1'8 not completely predictablefol' t he yeaI' 011 tire nome front: ALLIED HEADQUARTERS IN WASHINGTON (AP) Planes AUSTRALIA Friday (AP)-A en 0 ugh to "counter" Japan's . ' stepp~up air attack in the strQng Japanese attempt to sUQply southwest Pacillc will be forth, More food produccd Lhan in l'eeonl-bl'cokiJ1g 1942 but less of it for civiliull consumption, and man their bases at Wewak, on coming, Secretary of War Stimson thc north coast of New Guinea, assured his weekly press conferLO 'DON (AP )-GcI'mariy's war in dustries werc dealt auother 'shatlCl'Ulg blow )Yednes· dllY night whell Britain's bQlhb· eni ll!!\de !l "very hea\'y'.' a,t · tuck 011 StllHgal't, lellving tremendol1s .fires l'oll).'illg flnq dell , e smoKQ billo,\ling 14,000 ,feet a\,lovc one of the nemy's , ffiost v i tal a J'I~lam ent an c1. en gin eerin8' 'rhis is the pialure : "Consen 'ati\'cly and l'oughly esti mated, anu assuming average weather, ci\' iliuns ,vi II have about 3 pel'cent morc foo(l thllll iu the pre·war years but about 6 percent less tbon in 1942. now is under attack by General ence yesterday. . Douglas Macm1hul."s bombers. "We will keep our American and Australian Wcrs supplied with Today's communique disclosed sulCicient plancs not only to re"'I'hcl'e will be little fancy food but there will b(J enough of it i/, it is f~il'ly shlll'cd u nd con· T SC~~~';':PO I't, months in prepaI'· AfL Faction 01 WLB that an enemy convoy at six Inerplace our losses but to build up chant vessels and thl'ec warships OUt' aircraft to counter the, Increaswas sighted approaching' Wewak ing eJ1emy air strength," l'\e said. ana were. immcdlately bombed, "The needs of the southwest Pi!thl'ec of the mcrchantmen' beIng clIic are being kept conll,tantly in alioll, asserted its purpose was neitber to "alarm nor reas· sure." It added: Varies Periodically "The tood situation is not enUrely predictable, Requirements vary from time to time. Supplies 01 any given place at any ,;:iven time depend on varyjng factors. Production depends ' on weather nnd other fluctuating influences. The result is constant change. "American civilians, therefore, must expect inconveniences trom time to timc and understanding o[ Ihi. iact I. Illost important in comprehcndlng thc rood situation." Elmer DiVis, OWl director. told a press conference Wednesdar the food report had becn held UP since JanuarY'. He exlIIalne4," There were 'dlfferences between two government (acricallure department) agencle'i over what were the facts." Recently, he said, he bad held it uv so additional facts could be inserted. As originally written in January, the report was part of a Iharp controversy within the OWl itself, according to staff members of the agency. Fifteen of them who recently resigned issued a statement yesterday saying they were leaving "because of our conviction that it is imposisble 101' us to tell the truth." "There is only one issue the deep and fundamental one of the honest presentation of war information." they said. OWl Do"lnated OWl is now dOminated, tlley deciared, I>y "high-pressure promoters who prefer slick salesmanship to honest information." Davis, in a statement of reply, IlS.ierted, "We deal in one plain commodl.ty-the facts the people of Ihis country need to win the war ... All facts must be presented accutately and in proper proportion. ~motional appeals of the type usually associated with promotional activities are not applicable to war problems .. . We are content to I>e judged by our output," The success of the food manarement program. the OWl report aald, depe'" on the cooperallon of manJ' ,rouPll: lar«e DrOduetion ~7 faJ'lben and VlcIor7 gardeners, ,ood plannlll&' IItd administration by the fOVehllllent, carellli buyinar and eookln, by houseWJves, enlarge· IIent of the farm labor supply from many 80llJ'CeH, and many fiber f.rmH of cooperation. But the OWl added: ,"Assuming complete success of 1be program, there still wi LI be lIlore 0[' less scvere clvllian shol'tiC6 of certain foods trom tlme to lime. There will be more Or lea., continuous lihortages of some kinds of lood such as canned fnUta Bnd vegetables, dehydL'ated IIgs and milk, meat prod ucts, ~, which are particularly lIdapted to milItary lise and over~ shipment, . "Tbere wLU be Intermittent I/lortaaes locally of several dilferent kinds of food resulting from transpottation difficulties, unus1IIl emeraeney demands of the armed forces, the initial disloco.UOIII reaultina from 100titution at and changes in ration Ina and other , Prol1'IDl and, (untU th.y are suppl'eued) from bla~ Ul¥rltets." Opposes Anti-Inflation Order by· President mind and there will be a conhit heavily. stanUy increasing Dow of military I An ~,()OO-lon ship was obseL:ved supplies, particularly aircraft. to


Autumn olive (Elaeagnus umbellata Thunb.) is a deciduous shrub tree widely distributed in Asia and Southern Europe and grown as ornamental species. It is locally used for human consumption, as relevant medical value is attributed to the berries. Information about its composition, especially concerning the characterization of bioactive and health-promoting compounds, is limited. The aim of the present study is to evaluate the main bioactive compounds and nutraceutical proprieties of autumn olive fruits, via high-performance liquid chromatography (HPLC) fingerprint and spectrophotometric analysis, in order to strengthen the knowledge about this underrated species and promote potential applications as a food supplement. Concerning nutraceutical traits, total polyphenolic content (325.366 ± 13.019 mg of gallic acid equivalents (mg GAE)/100 of fresh weight (g FW)) and total anthocyanin content (194.992 ± 0.817 mg of cyanidin-3-O-glucoside (mg C3G)/100 g FW) recorded considerable values. The phytochemical fingerprint revealed the presence 23 bioactive compounds. Polyphenols (65.56%) were the largest class, followed by monoterpenes (27.40%) and vitamin C (7.04%). Anthocyanins were the most represented compounds among polyphenols (71.9%). The antioxidant capacity (20.031 ± 1.214 mmol Fe2+/kg) was similar to that recorded for other small fruits with proven health-promoting properties. The present work underlined the potential of E. umbellata as a source of health-promoting bioactive compounds. Further studies should deepen the knowledge of nutraceutical aspects, which turned out to be interesting.


Floral biology of seven litchi cultivars (China, Deshi, Elaichi, Kasba, McLean, Nafarpal and Piazi) was studied. Cultivar Deshi showed panicle formation on 2nd January, while panicle initiation was early (10th February) in cv. Piazi. Flowering duration varied between 13±4 days in 'China' and 30±3 days in 'Piazi'. Male:hermaphrodite flower ratio was maximum in 'Piazi' (5.8:1) and minimum in 'China' (2.74:1). In general, anthesis was maximum between 7 and 8 AM, while, anther dehiscence was maximum between 9 and 10 AM. Percentage of viable pollen varied between 82.14% in cv. Elaichi and 91.38% in cv. Piazi Pollen germination was higher in 15% sucrose solution.


Induction motor is singly excited motor, which is very simple, compact and extremely rugged in construction and most reliable and low cost motor. Although, these motors are reliable but often exposed to hostile environments during its operation which results to early deterioration and in turn lead to the motors failure. Faults and failures of induction machines can lead to excessive downtimes and generate large losses in terms of maintenance and revenues. This paper deals with the study of identification of different type of faults and the health monitoring techniques commonly used in induction motors.


This paper briefly analyses the frame construction of the Jiangdu community antenna television broadband integrated service information network,and further introduces the network security tactics and the achievement of the network management system.


In this paper, the design of coating system, choose of materials, technology of fabrication, as well as the experimental results for the damage threshold and thermal deformation of the cavity mirrors of DF laser are reported. The experimental results show that the thermal deformation of he cavity mirrors of DF laser is about 0.3λ (λ=632.8 nm) under the power density of 21 kW/cm 2, and the damage threshold of the cavity mirrors of DF laser is higher than 40 kW/cm 2.


1. Statement of Problem.-Many problems in plane potential theory can be solved easily, if one knows how to map the interior (or exterior) of a given closed curve C in the z-plane, conformally and one-one onto the interior (or exterior) of the unit circle t = e"' in the t-plane. This can be done by tabulated functions in some cases, but even in such cases, the solution often involves one or more symbolic parameters, whose numerical determination is awkward. Therefore, there is great interest in obtaining direct iterative or other numerical procedures, applicable to all sufficiently regular domains. Many such schemes have been proposed, of which the most widely used is due to Theodorsen and Garrick.' The analytical formulae involved in these schemes have all been known, or could have been derived easily, since the time of Riemann, Schwarz and Neumann. However, there is a tremendous variation in the accuracy which can be achieved in a limited number of steps, and in the amount of data which must be stored, depending on the method used. We have tried to develop schemes practicable for high-speed computing machines with limited "memories," giving good accuracy in a limited (105-106) number of steps. We outline below two new schemes, one for computing t = f(z) from z, and the other for computing z = g(t) from t, which seem to us to offer various advantages. In addition, an analogous scheme for computing steady plane flows with free boundaries is described. 2. First Solution.-To compute f(z), it seems most convenient to consider


The ) account of seven stages of learning is considered in the context of the Dreyfus (1980s) account of five stages of skill development. The two new stages, Mastery and Practical Wisdom, make more explicit certain themes implicit in the five‐stage account. In this way ) encourages a more reflexive approach. The themes now more explicit are, in part, derived from Aristotle on phronesis, but are also influenced by Heidegger and Foucault on cultural dimensions of meaning and value. The paper considers whether Dreyfus' revised account tends towards a relativism of different worlds of meaning, disclosed through personal commitment. A more reflexive account of phronesis, it is suggested, needs to clarify the potentiality of phronesis for co‐ordination as it promotes patterns of unity in difference and difference in unity.


Job satisfaction is a multifaceted phenomenon and it affects nurses' productivity and performance, cost saving, quality of patient care, patient safety, commitment to the organization and the profession. Besides, job dissatisfaction affects to the rate of absenteeism, turnover, intent to leave and migration. No studies have conducted to study the predictability of organizational structure and leadership form of nurse managers on nurses' job satisfaction in Sri Lanka. The objective of this study was to examine the level of job satisfaction among nurses in a government hospital in the central province, Sri Lanka and to assess the predictability of organizational structure and leadership of nurse managers on job satisfaction among nurses. The sample consisted of 160 registered nurses in government hospital in the central province in Sri Lanka and completed measures on the job satisfaction (McCloskey/Mueller Satisfaction Scale), organizational structure (Alexander Structure Instrument) and perceived leadership form of nurse managers (Perceived Leadership Form Questionnaire). The results of the study showed that this sample of nurses was moderately satisfied with their job. Further, transformational leadership form of nurse mangers explained 32.9% of predictability in job satisfaction among nurses. The results suggest that transformational leadership form of nurse mangers as an important predictor of nurses' job satisfaction. These findings also serve as foundation knowledge for developing strategies to enhance job satisfaction among nurses.


Deep-blue electroluminescence with a maximum EQE of 5.74% and CIEy ∼ 0.05 is achieved based on a newly designed D–π–A fluorophore with a HLCT excited state.


One of the disadvantages of using steel powders is the difficulty of producing such materials. In this article, steel powders from various manufacturers were discussed. The analysis of the surface, powder particles and the distribution of the fractional composition and the possibility of reuse was carried out. Direct laser deposition modes, using different laser power, were designed. From the obtained modes, tensile and impact bending samples were grown, and a comparative analysis of the obtained results was carried out.


Acute myocardial infarction during pregnancy or postpartum period is a rare but life-threatening
condition associated with poor maternal and fetal outcome.
Although atherosclerotic coronary artery disease is the most common etiology in general population, the causation is more
diverse in pregnancy and this may have therapeutic implications.
Early diagnosis and timely management with collaboration among Maternal-fetal medicine specialist, interventional
cardiologist, cardiac anaesthetist, intensivist and neonatologist is essential to prevent maternal cardiac deaths.
We present a case series of two patients with postpartum and antepartum acute MI, respectively and their diagnosis,
management and outcomes in a tertiary care center.


The predicting issue the mechanical properties of the product in the design of technological processes for the heat treatment of Ni–Fe 901 alloy is considered. Mathematical model for the artificial ageing process of the alloy is constructed, which makes it possible to calculate the volume fraction of the strengthening γ′-phase and the size of its particles depending on the temperature and time of ageing and, therefore, mechanical characteristics of the finished product. Technique for using the developed model is presented, which is flexible and can be refined as experimental data from production is accumulated.


In Nigeria today, most speakers of English are second users of the language because they acquire their different mother tongues before they come to learn English. This article studied the phonological deviation among speakers of English at the Federal Polytechnic. Nasarawa. Adopting the survey research design, the oral production test (OPT) was used whereby thirty (30) students were randomly selected to speak on some topical issues and issues; related to academics such as Examination Malpractice in Nigeria's Higher Institutions, Campus Gangsterism, High Rate of Unemployment in Nigeria, The 2019 General Election and hate speeches among politicians during the 2019 electioneering campaign. The student's speeches were recorded and transcribed in their raw forms and compared with the Received Pronunciation (RP) for the purpose of analysis. The results showed that there were deviations in the production of some sounds that are not present in the phonetic inventory of most Nigerian languages as well as wrong placement of stress on English words. The results also showed that the mother tongue plays a significant role in the wrong pronunciation of English words by most Nigerian English bilinguals.  Article visualizations:


The unprecedented increase in Nr is causing several environmental problems such as eutrophication, ozone depletion and climate change etc. Excessive Nr creation is also responsible for poor plant and human health, soil acidification, groundwater contamination etc. Inhabiting ~ one-fourth population of the world and sharing only 4.9% of land of the total global landmass, the South Asian region consumes 60% of the total global fertilizer nutrient. India is the largest consumer of synthetically produced fertilizer in South Asia. According to estimates, India consumes ~ 17 million tonnes Nr/yr, making South Asia and India a hot spot for the deposition of N species. In India, the fertilizer N consumption is increased 314 folds from 1950-51 to 2013-14. In 1951-52 per hectare fertilizer N consumption was 0.44 kgha-1 while it was 86.2 kgha-1 in 2013-14. Since rains are limited to a few months, most of the time the weather is hot and dry. And hence, the dry deposition is the key mechanism of pollutant removal in the region. Wet deposition predominantly occurs during the monsoon period. The wet deposition of NH3-N observed to be the highest in the Indo-Gangetic plains. The annual NO3-N deposition at the urban, suburban, rural and industrial site found to be 4.48, 2.10, 4.06 and 3.92 kgha-1 respectively, and the annual deposition of NH4-N at the urban, suburban, rural and industrial site found to be 2.38, 2.10, 2.38 and 5.05 kgha-1 respectively. The average total wet deposition of NO3-N and NH4-N in India is estimated to be 6.01kgha-1 which is equivalent to 1.97 Tg N/yr. The average total dry deposition of NH4-N and NO3-N through dust fall found to be 0.37 kg ha-1 and 0.84 kg ha-1 respectively. The average total dry deposition of NH4-N and NO3-N in the form of aerosols found to be 0.28 and 1.65 kg ha-1 while through gaseous dry deposition it was 4.72 kg ha-1 and 0.28 kg ha-1 for NH4-N and NO3-N respectively. This study highlights the need for integrated nitrogen monitoring and assessment in South Asia.


Development of internet and electronic business give birth to many complicated civil jurisdiction over issues.There are many problems in American and European jurisdiction.In building up Chinese jurisdiction system,it is necessary to guide network's sound development.


Objective: To investigate the anxious emotions of acute cerebral vascular disease and the curative effect of psychology recovery in early stage. Methods: 180 cases of acute cerebral vascular disease patients randomly selected were assessed by using 3 survey clocks including Hanmition anxiety, Anxiety evaluation and Society support and the logistic multivariate regression analysis. 120 patients who had anxious emotions were randomly divided into two groups: treatment group and control group. Both two groups were treated with the medicines, but in the treatment group, the patients were subjected to psychology recovery at the same time. Results: The occurrence rate of the anxious symptom was 66.67 %. There was significant difference in the anxious scores between the focus of infection in the front of the cortex and that in lower and posterior parts of the cortex with the former being obviously higher than the latter. The anxious emotions could be obviously improved after the patients received psychology treatment in time. The cure rate and effective rate was 65 % and 93.33 % respectively, significantly higher than in the control group (40 % and 60 % respectively). Conclusion: The occurrence rate of initial anxious emotions of acute cerebral vascular disease takes 2/3 proportion. The severity of the anxious emotions is closely related to the psychology and the position of the lesions. Medication in combined with psychology recovery treatment in time can obviously improve the curative effects.


Objective: To study the apoptosis of leukemia cells induced by antisense oligonucleotide targeting survivin and etoposide(VP-16).Methods: Oligonucleotides were delivered in the form of complexes with Lipofectin.Then treated with VP16.Examined The expression of survivin Caspse-3 by immunohistochemistry(SABC).And detected the apoptotic rate of each group with two methods: TUNEL assay and Annexin V-FITC assay.Results: The protein of survivin is overexpress in K562 cells,but after treated with antisense oligonucleotide,the level of expression was down regulation.After transfection,the expression of caspase-3 of ASON group was upgrade contrast to other three groups(P0.05).The apoptotic rates detected by TUNEL assay and Annexin V-FITC assay.Conclusion: Antisense oligonucleotide targeting survivin can down regulate the protein expression of survivin,and can sensitize K562 cells to chemotherapeutic agent etoposide.


At Texas A & M Corpus Christi (TAMU-CC), the university's required database management systems (DBMS) class teaches students the theory and practical skills required to create efficient database systems. In addition to the theory and skills, the DBMS class at TAMU-CC teaches students to become Web database application developers and to configure their own home PC's as Web servers for their databases. Projects are built upon real-world needs and actually implemented. This approach requires little or no expenditure by the university or the student, but gives the student a realistic project using readily available Web tools. This paper gives concrete examples of projects as well as where to obtain supporting components.


The goal of this research was to analyze the ectoparasitic species from domestic cats in Joao Pessoa city, Paraiba state, Brazil. A total of 432 cats of various breeds and ages, of both genders, were included. All animals  were submitted to physical and parasitological examination through skin inspection and an otoscopic exam was realized. Parasites were collected in vials containing 70% alcohol for subsequent mounting and identifi cation according to specific keys. The results showed that 62.7% (271/432) of animals were parasitized by one or more species. The ectoparasitic species observed were Ctenocephalides felis (27.3%), Lynxacarus radovskyi (26.2%), Otodectes cynotis (17.4%), Felicola subrostratus (9.7%), Notoedres cati (2.1%) and Rhipicephalus sanguineus (1.6%). The results showed that ectoparasites are a common and important skin disease in cats, and variables such breed, age, and sex did not show any influence on parasitism.


ABSTRACT This study attempts to determine if individual differences in multitask performance are due in part to the cognitive competence (i.e., the consistent, rule-based strategy-) the subject brings to the task. A battery of learning (discrimination shift, transposition, incidental learning and paired-associate learning), cognitive-developmental (seriation, conservation of amount and transitivity) and psychometric (Raven's Colored Progressive Matrices) measures were administered to 120 children from kindergarten and second grades. Similarities and differences underlying children's problem-solving performance during this time were then assessed. Subjects were categorized into one of three performance levels for the criterion tasks, e.g., conserver/nonconserver/inconsistent conserver. Overall performance, as a function of ages sex and the respective performance categories, was assessed via canonical correlations and multiple regression analyses. The results indicated that performance on reversal shift and conservation alone predicted overall multitask performance (p<001). Moreover, there appeared to be a trend toward improved overall performance from nonperformers through inconsistent performers to perfect performers on the conservation task. The results suggest that while both reversal and conservation are Indices of mediation, albeit rule-based strategies, conservation is a far more powerful predictor of overall task performance. These results suggest the feasibility of using multitask, multidomain research to better understand the nature of the development of cognition in children. (Author/MS)


Because the increase in demand of PET bottle in the field of the domestic food,beverage,wine,medicine and other areas of consumer goods,the PET blowing compressor market is developing.It exhausts pressure between 3.0 MPa~5.0 MPa,with piston type compressor 3 stage tandem.The single screw compressor has been the core technology breakthrough,with single stage compressor exhaust pressure to achieve 3 MPa.The single screw compressor are better than the piston type compressor in the structure,stability,reliability,life and other aspects of technical performance which brings the development of PET blowing single screw compressor.


The primary and secondary education in Finland has gained much national attention,which is largely due to the impressive results in the PISA surveys,and high-quality teacher education is undoubtedly an important guarantee factor for the success of the primary and secondary education in Finland.According to the requirements of the Bologna process,the primary and secondary teacher education in Finland has reformed on entrance requirements,training objectives and curriculum and has shown such trend as the expansion of teacher mobility,extended teacher competencies,improvement of teachers' researching level and the transformation of curriculum design model,which can provide some reference for the reform of teacher education in China.


Early progression of disease, within 2 years of diagnosis, is linked with poor overall survival in follicular lymphoma but its prognostic role in extranodal marginal zone B-cell lymphoma is less clear. We sought to identify prognostic factors associated with early progression of disease and to determine whether early progression is associated with inferior overall survival. We analyzed the impact of early progression of disease using the dataset of the International Extranodal Lymphoma Study Group-19 (IELSG-19) clinical trial (training set of 401 patients randomly assigned to chlorambucil or rituximab or chlorambucil plus rituximab). Reproducibility was examined in a validation set of 287 patients who received systemic treatment. We excluded from the analysis patients in both sets who, within 24 months of starting treatment, died without progression or were lost to follow-up without prior progression. Overall survival was calculated from progression in patients with early disease progression and from 24 months after the start of treatment in those whose disease did not progress early (reference group). Early disease progression occurred in 69 of the 384 (18%) evaluable patients of the IELSG-19 study. Patients with a high-risk Mucosa-Associated Lymphoid Tissue - International Prognostic Index score were more likely to have early disease progression (P=0.006). The 10-year overall survival rate was 64% in the group with early disease progression and 85% in the reference group (hazard ratio = 2.42; 95% confidence interval: 1.35-4.34; log-rank P=0.002). This prognostic impact was confirmed in the validation set, in which early progression was observed in 64 out of 224 (29%) evaluable patients with 10-year overall survival rates of 48% in the group with early disease progression and 71% in the reference group (hazard ratio = 2.15; 95% confidence interval: 1.19-3.90; log-rank P=0.009). In patients with extranodal marginal zone B-cell lymphoma who received front-line systemic treatment, early disease progression is associated with poorer survival and may represent a useful endpoint in future prospective clinical trials.


Electrochemical reduction of nitrogen (N2), in which the conversion of N2 to ammonia (NH3) takes place under mild conditions, is of timely significance for paving a way toward technological applications in agriculture and the chemical industry. In this work, various single transition metal atoms anchored on graphitic carbon nitride (g-C3N4) with nitrogen vacancies (TM@NVs-g-C3N4), acting as electrocatalysts for N2 reduction, were systematically investigated by means of density functional theory (DFT) calculations. Most of the isolated metal atoms (Ti, V, Co, Ni, Zr, Mo, Ru and Pt) can be fixed by the nitrogen vacancies stably after performing the molecular dynamics simulation. For hexagonal close-packed and body centered cubic metal atoms, their N2 chemisorption activity decreases as the coordination number of the single atom rises. Nevertheless, the anchored cubic close-packed metal atom does not serve as a good site for N2 adsorption and activation even with a low-coordination number. Among all studied TM single atoms, the single Ti atom is found to be the most promising catalyst for its excellent N2 reduction performance with a potential-limiting step of 0.51 eV and a rate-determining barrier of 0.57 eV. Atomic level insights are provided to elucidate the electrochemical mechanisms for N2 reduction. The coordination number of the active center is accountable for the robust N2 reduction activity with high stability. Overall, this work exemplifies the in-depth investigations of different single TM atoms, including the coordination number and binding mode, which are essential to lay the groundwork for the advancement of single atom catalysis toward practical implementation.


In order to improve teaching quality, realize teaching target and promote students' ability of listening and speaking, Listening Comprehension of College English must insist on combining listening and speaking, implementing the principles of progressing step by step, uniting intensive reading with extensive reading and putting humour into teaching.


The invention relates to a drive method of a field-sequential LCD device. The LCD device comprises a plurality of monochromatic backlight sources, each frame image is divided into a plurality of sub-fields, and a plurality of sub-fields are matched with the corresponding monochromatic backlight sources and sequentially displayed, wherein, the display time sequence of a plurality of sub-fields of two adjacent frames are different. The drive method of the field-sequential LCD device improves the color breakup of the field-sequential LCD device.


We report on headache induced by a somatostatin octapeptide analog (octreotide) used for the treatment of acromegaly, This "rebound" headache has severe tension-type characteristics and occurs every 6–8 h. It resolves dramatically within minutes with octreotide administration. This is the first report of headache developing under treatment with octreotide.