Abstract : In this report, we include the dissertation thesis the grant has funded together with a list of publications, and invitations the funded research has generated. Concepts in classification and recognition problems. 1. We have explored the potential of combining geometrical as well as topological information in capturing the essence of an object for classification and recognition purposes. The geometrical information within a topologically homogeneous part of an object is captured through a set of level curves, while the topology is extracted from the singular points. 2. Defining probability models on manifolds as would be required by the surface of an object remains a challenging topic. The approach here exploits a triangulated approximation on which a geodesic is defined to capture the nonlinear intrinsic structure of an object surface. 3. Obtaining distribution for objects in turn allows us to compare them by IT measures.


This article proposes a phase I/II clinical trial design for adaptively and dynamically optimizing each patient's dose in each of two cycles of therapy based on the joint binary efficacy and toxicity outcomes in each cycle. A dose-outcome model is assumed that includes a Bayesian hierarchical latent variable structure to induce association among the outcomes and also facilitate posterior computation. Doses are chosen in each cycle based on posteriors of a model-based objective function, similar to a reinforcement learning or Q-learning function, defined in terms of numerical utilities of the joint outcomes in each cycle. For each patient, the procedure outputs a sequence of two actions, one for each cycle, with each action being the decision to either treat the patient at a chosen dose or not to treat. The cycle 2 action depends on the individual patient's cycle 1 dose and outcomes. In addition, decisions are based on posterior inference using other patients' data, and therefore, the proposed method is adaptive both within and between patients. A simulation study of the method is presented, including comparison to two-cycle extensions of the conventional 3 + 3 algorithm, continual reassessment method, and a Bayesian model-based design, and evaluation of robustness. Supplementary materials for this article are available online.


The aim of this study is to analyze spoken linguistic features of three-minute startup pitches. Linguistic features analyzed included discourse markers, dysfluency, modality, numeral phrases, pronouns, reduced forms, repetitions, rhetorical questions, vague expressions, and vocatives. The corpus is comprised of 92 startup pitches delivered in real time at a pitching competition as part of an international technology conference. The pitches were transcribed, and linguistic features were identified with the aid of concordance software. Results from the analysis of linguistic features show that startup pitches contain aspects typically found in spoken genres, reflecting orthographic transcription, real time, shared context, interactivity and style.


The article takes the old town of Lijiang as an example and explores the coordination development of historic cities and commodity economy. Based on some issues, with some theories and cases, the article analyzes the main ques- tion from four aspects: regional, cultural, industrial and managerial. Finally, the article summarizes the coordination and gives some suggestions on it.


For more than half a century it has been hypothesised that organisational culture is a single, homogeneous and consistent phenomenon, which provides an overarching set of meanings shared by all organisational members. Increasingly, however, the efficacy of this approach has been tested as a small number of scholars have put forward an alternative hypothesis – that, like the societies they are part of, organisations are more likely characterised by pluralism, heterogeneity and ambiguity. The possibility of subcultures as the dominant expression of organisational culture has gained support as a means to understand and explain the cultural milieu of the highly complex organisations of the 21st century. This research, an embedded single case study, examines the procurement directorate (PD) of a large, multinational energy company, to identify whether subcultures exist in this context, and if so, whether they can be defined using current theoretical concepts. Content analysis of the data shows that a number of unique subcultural groups do exist, which are delineated by a variety of unifying characteristics and physical manifestations of the group"s culture. These distinct subcultures emerge as being influential in a variety of different ways: at the operating unit level through sustaining harmonious relationships with one another and supporting the day-to-day work of the directorate; and at the organisational level through fostering positive relationships between group members and ZAOC Norge and the overt support of important organisational meanings. The findings from this study suggest that subcultures are central to the cultural environment of the PD and


We show two methods for measuring non-random observations using statistical control software, specifically SigmaXL, across diverse time series. First, we use an error counting method based on eight non-random rules of statistical control charts, and subsequently we assign a dollar value to each of those non-random observations to evaluate non-random to random rates. The computed error rates are also compared to a randomly generated sample of 100K and the corresponding probably of occurrence. Finally, these methods, coupled with a new indicator, the Taylor-Kiymaz multiple, allow for the comparison of stock prices, market indexes, sales metrics, chart of accounts across many time periods.


Iron nanoparticles (FeNPs) are the tiniest particle of iron metal with a large surface area and high reactivity. They are non-toxic. FeNPs have excellent dimensional stability and also possess high thermal and electrical conductivity, high surface area, and are highly magnetic. FeNPs can oxidize immediately when exposed to water or air and produces free Fe ions. There are numerous applications of FeNPs but the most promising one includes their role in drug delivery. Considerable attention is being paid to the utilization of computer-based and modeling optimization in fuel cell systems design. One advantage of this method is the positive effect on high cost and design cycle time savings, as well as its improved operation and design. The performance of optimum development depends primarily on the method by which the prototype is developed. It is crucial to identify the important factors and those that can be compromised without having an adverse effect on the design. Modeling is carried out to capture the designer's interest aspects of the fuel cell system. A mathematical model that represents particular fuel cell system aspects and estimates its characteristics can be in a form of algebraic equations, differential equations, or a process or subroutine based on a computer. The model can involve various alternatives to the design that can be achieved by changing parameters, variables, constraints or conditions. The principle explained in the preceding step contributes to the basis for comparing the various alternatives to design.


Authors : Asta Raceviciute-Stupeliene, Vilma Sasyte, Vilma Viliene, Virginijus Slausgalvis, Jamal Al-Saifi, Romas Gruzauskas Abstract : The objective of this study was to investigate the influence of special additives such as chelators, zinc sulphate and cilicic acid on productivity parameters, carcass characteristics and meat quality of pigs for fattening. The test started with 40 days old fattening pigs (mongrel (mother) and Yorkshire (father)) and lasted up to 156 days of age. During the fattening period pigs were divided into 2 groups (control and experimental) after 4 replicates (total of 8 pens). Each group was followed by 16 fattening pigs. The pigs were fed for 16 weeks' ad libitum with a standard wheat-barley-soybean meal compound (Control group) supplemented with chelators, zinc sulphate and silicic acid (dosage 2 kg/t of feed, Experimental group). Meat traits in live pigs were measured by ultrasonic equipment Piglog 105. The samples for the analysis of physical and chemical properties, cholesterol content were taken The results of the present study suggest that supplementation of chelators, zinc sulphate and silicic acid during all experimental period tends to positively affect on average daily gain and feed conversion ratio of pigs for fattening (P < 0.05). Pigs evaluation with Piglog 105 showed that thickness of fat in the first and second point was by 4% and 3% respectively higher in comparison to the Control group (P< 0.05). Carcass weight, yield and length, also thickness of fat showed no significant difference among the groups. The water holding capacity of meat in Experimental group was by 5.28% lower and tenderness – by 12% lower compared with Control group (P < 0.05). According to the pig meat chemical composition of the treatment groups, a statistically significant difference among it was not determined. Cholesterol concentration in muscles of pigs for fattening fed diets supplemented with chelators, zinc sulphate and silicic acid was lower by 7.93mg/100 g of muscle in comparison to the Control group. These results suggest that supplementation of chelators, zinc sulphate and silicic acid in the feed for fattening pigs had significant effect on its growing performance and meat quality.


Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 764738. British Heart Foundation Intermediate Basic Science Fellowship (FS/17/22/32644).

 The pathogenic TNNI3R21C/+ variant causes malignant hypertrophic cardiomyopathy (HCM) with high incidence of sudden cardiac death, even in individuals absent of hypertrophy. There is evidence to support a known biophysical defect in the protein, yet the cellular mechanisms that precipitate adverse clinical outcomes remain unclear.

 We aim to computationally model and map the TNNI3R21C/+ cellular phenotype observed in induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) to human disease, thereby explaining the key mechanisms driving HCM in TNNI3R21C/+ variant carriers.

 Wild-type (WT) and TNNI3R21C/+ iPSC-CMs were characterised by calcium transient analysis and direct sarcomere tracking to assess cellular contraction and relaxation. In-vitro data was used to inform the in-silico modelling of human cardiomyocytes. We constructed an in-silico population of WT adult cardiomyocytes and used it to transform the in-vitro data into corresponding adult phenotypes by means of a novel iPSC-to-adult data mapping. We tested the hypothesis that the abnormal TNNI3R21C/+ phenotype observed in iPSC-CMs would be explained by alterations in calcium affinity of troponin and increased myofilament calcium sensitivity.

 Analysis of in-vitro iPSC-CM data showed that TNNI3R21C/+ cells exhibit increased contractility with slowed relaxation when compared to WT. They also exhibited a faster rise in the calcium transient with a slowed calcium decay in comparison to WT. The in-silico adult TNNI3R21C/+ phenotype from the iPSC-to-adult mapping replicated the abnormalities observed in iPSC-CMs. The WT in-silico population accurately covered the ranges of electromechanical biomarkers providing a representative cohort of physiological variability. The TNNI3R21C/+ calcium phenotype could be recovered by our in-silico mutant models. Simulation results suggest that calcium abnormalities in TNNI3R21C/+ are a direct consequence of abnormal calcium buffering by thin filaments, mediated by increases in calcium affinity of troponin and myofilament calcium sensitivity. The TNNI3R21C/+ phenotype could not be recovered if these two factors were considered in isolation. Corresponding contractility analyses of in-silico models showed that the calcium level changes caused by the TNNI3R21C/+ phenotype are associated with hypercontractility and diastolic dysfunction, well-known hallmarks of HCM, which were also observed in the iPSC-CM model of disease.

 This study showcases human-based computational and experimental methodologies that unearth direct mechanistic explanations of phenotypes driven by the TNNI3R21C/+ HCM variant. We show that the TNNI3R21C/+ HCM-causing mutation exhibits multifactorial remodelling of troponin calcium affinity and myofilament calcium sensitivity. Unearthing mechanistic pathways in mutation-specific HCM will be key to develop effective pharmacological interventions for a wide variety of understudied variants.


Elevated reactive oxygen species (ROS) have been implicated in the pathogenesis of many diseases, including atherosclerosis and Parkinson's. Foods rich in polyphenols such as fruits, wines and teas have proven to decrease oxidative stress. Further, antioxidant properties of polyphenols increase cell viability under oxidative stress conditions and increase overall health. In the current study 12 polyphenols were screened for their ability to increase viability in PC12 cells subject to oxidative stress induced via cobalt chloride (CoCl2) and hydrogen peroxide (H2O2). Results from MTT assays show that pre‐treatment with 50µM methyl gallate increases cell viability by 26.6% (P<0.01) under H2O2 stress and does not increase viability under CoCl2 stress. Pre‐treatment with 100µM epigallocatechin gallate (EGCG) shows a 63.4% (P<0.01) increase in viability compared to control, however shows no viability increase in stress conditions. Treatments with 50µM myricetin and gallic acid show no effect on basal viability and decrease viability when delivered as a pre‐treatment prior to H2O2 exposure. Remaining polyphenols did not alter basal viability or increase viability under stress. Lastly, DCFDA determination of intracellular ROS confirms the ability of screened polyphenols to significantly reduce ROS levels. These results suggest that methyl gallate and EGCG may have potential therapeutic properties.


Primary objective: To investigate the speed and accuracy of tongue movements exhibited by a sample of children with dysarthria following severe traumatic brain injury (TBI) during speech using electromagnetic articulography (EMA). Methods and procedures: Four children, aged between 12.75-17.17 years with dysarthria following TBI, were assessed using the AG-100 electromagnetic articulography system (Carstens Medizinelektronik). The movement trajectories of receiver coils affixed to each child's tongue were examined during consonant productions, together with a range of quantitative kinematic parameters. The children's results were individually compared against the mean values obtained by a group of eight control children (mean age of 14.67 years, SD 1.60). Main outcomes and results: All four TBI children were perceived to exhibit reduced rates of speech and increased word durations. Objective EMA analysis revealed that two of the TBI children exhibited significantly longer consonant durations compared to the control group, resulting from different underlying mechanisms relating to speed generation capabilities and distances travelled. The other two TBI children did not exhibit increased initial consonant movement durations, suggesting that the vowels and/or final consonants may have been contributing to the increased word durations. Conclusions and clinical implications: The finding of different underlying articulatory kinematic profiles has important implications for the treatment of speech rate disturbances in children with dysarthria following TBI.


In this paper the possibility of improvement of emitted beam quality of high-power laser diodes by stabilization of an optical field distribution in the junction plane, forced by lateral periodicity built into their wide-stripe waveguide is described. Current flow control by such periodic structure prevents the lateral current crowding, carrier accumulation at the stripe edges and optical far-field blooming typical for conventional wide-stripe laser diodes. As a result, stabilization of the lateral emitted beam divergence in wide drive current range of CW operation has been evidenced.


The increased amount of attention focused on fungous infections in recent years has given rise to an ever greater number of new studies and observations. It has been interesting to note that in some instances cases of dermatophytosis of the feet are complicated by an eruption which bears great resemblance to erysipelas. The importance of recognizing this condition and differentiating it from true erysipelas is of obvious importance and prompts this report of eight cases. REPORT OF CASES Case 1.— C. W., a man, aged 52, presented by one of us1at the March 1935 meeting of the New York Dermatological Society, complained of an eruption which had appeared on several occasions over a period of a year. The eruptions were of an erysipelas-like character and usually appeared on the lower part of either leg. Sometimes the two legs were involved at the same time. They were characterized by


Antiepileptic drug (AED) tapering in persons with epilepsy (PWE) after 2‐3 years of seizure freedom is still debatable because of the risk of seizure recurrence. Tapering patterns have wide variability and could impact seizure recurrence; this study aimed to find out the correlation between them.


Abstract : A study with the goal of contributing to the development of adaptive phased array radar techniques is presented. Adaptive phased array radar is concerned with modification by closed loop control of the radar in response to a change of radar environment such that performance is improved with respect to performance before modification. This study has been concerned with selection of a quantitative measure of radar system performance and relating this measure of performance to control of phased array radar parameters. Modeling of the general radar problem has established a framework of language and functional representation. An adaptive illumination function synthesizer for a tracking radar operating in a point target environment was completed and significant progress was made on completion of an adaptive waveform synthesizer. (Author)


To the Editor:

I read with interest the contribution by Cai et al in the "Images in Cardiovascular Medicine" section of the journal.1 They described a patient who developed severe aortic regurgitation and a mitral valve aneurysm 1 month after successful treatment of Streptococcus mitis endocarditis. The case presentation and the title implied that the mitral valve aneurysm was caused by the effect of severe aortic regurgitation on the mitral valve and not directly related to endocarditis. I am unaware of other cases of mitral valve aneurysm as a result …


The subject of the study is the sources of protest moods of modern student youth. The research interest in protest moods is due to the fact that they are a latent stage of open protest actions, and their study provides an opportunity to regulate open protest: reducing its negative effects and increasing the positive ones. This article pays special attention to such a social group as youth. This is due to the fact that it is young people who are most often the main participants in protest actions due to their more acute perception of the imperfections of society and inflated expectations from themselves and others. The novelty of the study was to understand protest moods as one of the stages of the development of social protest. A methodology was developed and a sociological study was conducted among students of the Altai Territory, the purpose of which was to characterize the main sources of protest moods in the student environment. The research was implemented through a combination of quantitative (mass survey) and qualitative (in-depth interview and focus group) methods of collecting, processing and analyzing sociological information. The main conclusions of the study were the understanding of the sources of protest moods in the student environment as a combination of a number of factors: the conditions of the learning environment, relationships with the external environment, as well as the socio-economic and political situation in the state


The our country high school traditional news adopts principle, method, mode and news of writing the teaching to practice to exist a certain margin, have to carry on a reform in education. The teacher wants to notice the innovation of teaching principle, reforming in the teaching principle of the constitution of the foundation top teaching link of the enlargement fulfillment, strengthen high school news an education the exchanges and the cooperation of the realm and medium. Adopt an improvement of writing the teaching through a news, transport the fresh blood of high quality for our country journalism.


Representatives of 23 genera from 18 families of the milliped order Polydesmida were examined using optical and scanning electron microscopy. The fiber-spinning structures reported by Adis et al. (2000) from two pyrgodesmid polydesmidans were found on all specimens studied, though their arrangement and structure differed; a cluster with each of four spinnerets set in contiguous walled depressions was characteristic only of some families of the suborder Polydesmidea. Corresponding structures in some adults of the suborders Leptodesmidea and Paradoxosomatidea appeared nonfunctional and were not set in contiguous walled depressions. Spinnerets of members of the orders Chordeumatida and Callipodida are structurally similar to those of the polydesmidans, but putative spinnerets in the orders Siphoniulida and Stemmiulida show differences. The presence of these spinning organs may be a synapomorphy of polydesmidans and the nematophoran orders, supporting the view that Polydesmida is a member of the "eighth gonopod clade" postulated by Shear, Shelley and Heatwole (2003), and is not close to either Juliformia or Colobognatha.


In this project we describe the successful implementation of a computer kiosk system that collects health risk information directly from patients and provides both contextually relevant and patient-tailored health information. We include usage statistics for kiosks located in community settings and demonstrate that patients will readily utilize these kiosks to access health information.


Several mathematical models have been developed which describe various kinds of composition for secure systems. These models can be complex and unsatisfactory in the sense that it is difficult for a system designer to determine exactly how to connect components together to achieve a particular (security) property. We provide a simple mathematical model which we use to describe security policies and components. The model provides a means for describing the combination of both components and policies and for showing whether combinations of components will satisfy specified policies. If the system designer can describe a system in the terms we present, then the designer can use these terms to analyze some of the security properties of the system.<<ETX>>


Social and emotional learning is increasingly being recognized for its role in urban school reform despite current school improvement efforts focused on academic outcomes. This article presents a case study in community partnership between a middle school, a community-based organization, and a research university, to implement a social and emotional program in seventh grade social studies. Highlighted is the importance of trust and communication among all partners—including administrators, researchers, front-line staff, teachers, and students. It also suggests a framework to expand school partnerships to include schools of social work, especially when the focus is on social and emotional learning.


In all the taxa and genomic systems, numerous trn genes (specifying tRNA) exhibit at specific conserved positions nucleotide triplets corresponding to stop codons (TAG/TAA). Similarly, relatively high frequencies of start codons (ATG/ATA) occur in fungi/metazoan mitochondrial- trn genes. The last nucleotide of these triplets is the first involved in the 5′-D-or 5′-T-stem, respectively. Their frequencies are tRNA species dependent. The products of these genes which bear one or two types of these codons are called ss-tRNAs (for stop/start). Metazoan mt-genomes are generally very compact, and many same strand overlapping sequences may simultaneously code for tRNAs and mRNAs. However, this study suggests that overlaps are not a direct mechanism to substantially reduce genome size. For protein- encoding genes, occulting possible overlaps, there are only alternative start codons and/or truncated stop codons, but the first putative in-frame standard initiation codon or complete stop codon is in the upstream or downstream overlapping ss- trn sequences, respectively. Even if, to date, experimental data are missing, stress signals might regulate producing extended or not proteins. Finally, possible implications of tRNA/mRNA hybrid molecules in the "RNA world" to "RNA/protein world" transition will be discussed.


Providers are coming up short when it comes to HEDIS measures related to substance abuse. Here's how one health plan is changing that.


Article 12 (1) of the Korean Constitution accepts the principle of due process as a constitutional principle. The principle of due process stipulates the basic principle that criminal proceedings should be regulated in terms of guaranteeing basic rights. Therefore, if the investigation by the investigative agency violates the principle of due process, it is illegal. An investigation may conduct an investigation necessary to achieve its purpose (Article 199 (1) of the Criminal Procedure Act).
However, even if the necessity of such an investigation is recognized, it cannot be allowed if the means of the investigation are not equivalent to the purpose. As a general principle of investigation, the principle of considerability of investigation or proportionality of investigation is derived from the principle of due process. Specifically, the means should be suitable for achieving the purpose of the investigation (the principle of suitability), and the necessary means with the least infringement (the principle of minimum infringement), and there should be a balance between the benefits of achieving the purpose of the investigation and the benefits infringed by the investigation (the principle of balance).
Currently, drug crimes have difficulties in detecting criminals and collecting evidence due to the wider area and the trend of intelligence due to informatization. As a means of this, the need for a trap investigation will increase further. Nevertheless, it should be legally allowed only to the extent that it complies with the principle of due process and the principle of considerability or proportionality of investigation under Article 12 (1) of the Constitution.


We all know about Supplemental Siberia, and we know it's a problem, but we just don't know what to do about it. (By 'we', I mean those of us publishing in the fields of biomedical research. If you are reading this and you haven't or don't plan to someday do such publishing, and you are reading this for fun, it might be a good time to re-evaluate your meaning of 'fun'.) And for those of you who have not yet had an opportunity to publish and experience this desolate demesne where data goes to die, here's the thing. Once upon a time, long, long ago – when papers were actually on paper and 'download' meant taking a volume from a shelf (as in, 'Please, could you help me and download that volume 72 of the Journal of Lots of Molecules, I can't reach it and you're such a tall and strong human'. Hey, I'm an insectivore, 1931 Sticky Wicket


Abstract During 1995, the relationship between the nesting chronology of the Least Tern (Sterna antillarum) and the near-shore abundance of fish was examined at La Purinera, Sonora, the site of one of the largest known Least Tern colonies in northwest Mexico. Fish abundance was measured adjacent to the shoreline during early mornings using a beach seine net, and the sampling periods corresponded to different phases of the Least Tern's annual cycle. During this year, the nesting season (April to July) coincided with peak prey fish abundance, and peak hatching of tern eggs (early July) coincided with the greatest abundance of fish of adequate size for chicks. Departure of the terns from the area coincided with a marked reduction in suitable food in September. Collections of fish dropped and left uneaten by Least Terns in the colony contained five species, which were also present in the fish samples obtained with the beach seine net. The observations on foraging adult Least Terns and the collections of fish dropped in the colony suggested that the terns were preying mainly upon silversides (Leuresthes sardina, Colpichthys regis) and anchovies (Anchoa spp.). Terns foraged mainly on the bay side of the barrier beach where fish were more abundant. The results support the idea that seabird breeding and food abundance or availability coincide at the time of maximum need, when parents feed rapidly growing chicks.


The authors report on a high-speed Si bipolar self-aligned technology featuring deep trench isolation for low capacitances, a production-compatible 15-keV BF/sub 2/ base implantation for high cutoff frequency, and an advanced composite material spacer formation process which avoids any etch removal of the base profile allowing for perfect control of the base charge. This process results in extremely reproducible device characteristics. The authors fabricated transistors with measured cutoff frequencies in excess of 35 GHz and realized CML ring oscillators which achieved a minimum delay time of 24 ps/gate. To check for degradation effects arising from residues of fluorine due to BF/sub 2/ implantation they processed reference transistors with B bases implanted at effectively identical energies as the BF/sub 2/ devices. With respect to base/emitter breakdown characteristics, no significant difference between the two sets of samples was observed. Thus, it is concluded that a 15 keV BF/sub 2/ implantation for narrow base formation is a viable approach for realizing bipolar devices for high-speed ICs.<<ETX>>


In this paper, we report the design, fabrication, and demonstration of a compact, V-band, zero-bias, and linear-in-dB power detector based on our in-house metal–insulator–graphene diode fabricated on a glass substrate. The presented circuit is optimized for the frequency band of 40–75 GHz. The measured prototype shows a repeatable measured dynamic range of at least 50 dB with down to −50 dBm sensitivity on 500-<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula>-thick quartz substrate. It also shows input return loss better than −9.5 dB over the entire design bandwidth. The measured tangential responsivity for the fabricated circuit on glass is 168 V/W at 2.5 GHz and 15 V/W at 60 GHz. The obtained results together with the robust device fabrication based on chemical vapor deposition graphene promote the proposed scheme and device for repeatable, statistically stable millimeter-wave, and submillimeter-wave applications.


The modification on the surface of the polyethylene terephthalate (PET) polymer as a result of ArF (193nm) laser irradiation was investigated. Fourier transform infrared spectroscopy (FTIR) and energy-dispersive X-ray (EDX) spectroscopy was employed for examination of the chemical composition of irradiated surface and conical structure. FTIR spectroscopy indicates that by irradiation of PET, hydrophobic groups of the polymer molecules in the polymer chain have more freedom of movement and prevents from the interaction between water molecules and the hydrophilic groups on the polymer surface, and PET surfaces after exposure have become more hydrophobic. While the PET is irradiated by more than 800 pulses, its surface becomes hydrophilic, so that the surface of PET after treated with 1500 pulses, even become more hydrophilic than that of untreated one.


MexIHC is a bi-annual conference promoting the gathering of researchers, professors, students, and practitioners in the field of Human-Computer Interaction, Interactive Systems, and Usability. The main objective is to support the exchange of scientific results, their application in industry, and experiences in the evaluation of systems. MexIHC covers topics such as interface design, workplace studies, education and training in HCI, game design, mobile devices, user centered design and information technologies for development.

Nearly two years after the last MexIHC, it is our pleasure to welcome you to the 4th Mexican Conference on Human-Computer Interaction in Mexico City. On behalf of the entire organizing committee and all of the persons involved in making MexIHC 2012 happen, it is our great pleasure to welcome you to the vibrant capital of Mexico. Mexico City can be proud of being one of the most eclectic cities in the world in terms of people, food, architecture, history, and entertainment. We are sure that you will have a great time in this great city. We encourage you to explore it and its adventurous surroundings.


In case of steady uniform flow in alluvial channel there exist definite relationship between the mean velocity, hydraulic radius, water surface slope and characteristics of channel boundary. A resistance equation is required in design of irrigation channel, sediment transport studies etc. The problem of predicting the resistance to flow and velocity distribution is complicated by two factors i.e. bed configuration and flow of suspended sediment load, both has a significance influence on the mean velocity. In this paper attempt is made to review the regime theory, resistance to flow and suggested the regime type formulas for bed configuration using different approaches. Secondly hydraulic relations are developed by considering the influential parameter in the sediment transport, which can be used in evaluation of bedfonns.


Background: Sudan one of the largest countries in Africa. In recent survey by Sudan Ministry of Health, congenital heart disease (CHD) was found to be one of the top eight diseases that lead to death of children in Sudan. The cost of surgical operation, follow up and diagnosis are expensive and this may result some children present with complications. The aim of this study is to assess the role of diaspora and non-governmental organization (NGO) in helping Sudanese children with CHD.
 Methods: We assess the 6 years' experience in charitable initiative established by Sudanese consultant pediatric intensivist and cardiologist working in Doha, Qatar in partnership with NGO in Gulf countries and Sudan. Examples of these organizations were Patient Helping Fund (PHF) the largest medical charity in Sudan, Eid Althani charity association in Qatar with collaboration of the Federal Ministry of Health (FMH), Ministry of Health in Khartoum and Gazira states. We established the program of providing suitable care for in need children.
 Result: A total of 104 out of the 222 complex defects were considered for surgery, 118 underwent cardiac catheter interventions. The 30-days post-operative mortality was 14/222 (6.3%). The most essential post-surgical complications were postpericardiotomy syndrome, bleeding, and sepsis. Malnutrition poor socioeconomic status is significant factors negatively impact the outcomes. All surviving patients (n=208) remain in good clinical condition, and most are asymptomatic without any medications.
 Conclusions: The collaboration of Sudanese pediatrician living outside Sudan with local and international NGOs can significantly improve child health in Sudan.


Abstract

 Background: Tobacco use is an epidemic known as "the brown plague" affecting one billion lives in the 21st century and 80% in developing countries. Prevalence of smoking is especially high in patients with psychiatric illness with an ongoing debate over which comes first. Studies about nicotine consumption in psychiatric patients are few from developing countries. Hence, this study is designed to identify socio-demographic and diagnostic correlates of nicotine use.

 Aims and Objectives:- To estimate the pattern of nicotine use and determine the association between socio-demographic profile, onset of nicotine use, it's use as a coping mechanism, psychological association with nicotine use in psychologically ill patients.

 Material and methods:- A cross-sectional study including 101 patients with nicotine use and psychiatric illness were administered a semi structured questionnaire, Fagerstrom Test for Nicotine Dependence(FTND) and nicotine dependence syndrome scale. Data analyzed with mean, standard deviation, chi- square, ANOVA

 Results:-Nicotine use was more common in middle age group with alcohol dependence followed by depression. Nicotine use was not associated with background, socioeconomic status, gender. Majority tried to quit for health but what kept them with nicotine were drive, stereotypy, continuity, priority.

 Conclusions:- Nicotine is a commonly abused substance in psychiatric patients without a clear demarcation about the cause effect relationship. The existing study gives few insights into reasons for nicotine intake which was more so among the productive age group. Hence, there is a need for further research about psychotropic drug interactions with nicotine use and focus on integration of nicotine cessation into treatment of other psychiatric disorders rather than separate deaddiction clinics to alleviate the illness burden.


Protective behavior of organic coatinge of alkyd,epoxy,urethane and siloxance applied to silver solar cell interconnects and erosion of Ag were investigated by exposure experiments to ground simulation atomic oxygen(AO).Evaluations of their protective properties were made through assessing their mass cfhange characteristics,chemical and physical changes to Ao attack.The specimens,after exposure were analyzed with SEM/EDAX and XPS.The results indicated that the silver is heavily etched.some coatings such as epoxy,alkd,urethane are seriously degraded or removed as volatile oxides and morphology of coatings changes.It is evident that siloxane coatings have excellent properties for anti-AO attack.The erosion product consists of silicon dioxide layer of compact texture and is left on the surface to provide adequate protection fro further attack by the energetic AO.


In contrast to living pongids and fossil hominoids the teeth of Homo sapiens do not exhibit distinct cingular shelves. Modern human teeth do, however, possess an active cingular zone which serves as the point of origin for specific accessory cusps (BUTLER, Biol Rev 31:30, 1965). In the maxilla, this zone is active primarily on the lingual surfaces of the anterior teeth and the molars where lingual tubercles and Carabelli's trait are expressed, respectively. The mandibular teeth rarely exhibit any development from the lingual cingular zone, but a cingular trait of the lower molars referred to as the protostylid is sometimes evident on the buccal surface of the mesiobuccal cusp. In a previous study, association was demonstrated between lingual tubercles of the maxillary central incisor and canine (SCOTT, J Dent Res, 56:1192, 1977). To examine further the developmental interrelationships between traits derived from the cingular zone, the expressions of the lingual cingula of the maxillary molars (i.e. Carabelli's trait) and the buccal cingula of the mandibular molars (i.e. the protostylid) were subjected to correlation analysis. Six samples of Papago, Navajo, and Hopi Indians (n = 676) from the American Southwest were studied to measure association between Carabelli's trait and the protostylid. The expression of both cingular traits ranges from absence through subtle grooves and ridges to varying tubercle outlines and free-standing cusps, so ranked scales were used to score the degree of trait development. For Carabelli's trait, the classification includes absence and 9 degrees of trait presence while the scale for the protostylid follows DAHLBERG (In: BROTHWELL, D.R. (ed), Dental Anthropology, 1963, p 149) who defined 6 grades (excluding buccal pits) with absence and 5 degrees of trait presence. Although both traits can be expressed on all 3 molars of their respective fields, they are in highest frequency on the first molars. Analysis was therefore restricted to first molars as their cingular phenotypes best reflect the underlying genotype (SOFAER ET AL, Arch Oral Biol, 17: 811, 1972). Kendall's rank order correlation coefficient tau and the phi coefficient based on 2 X 2 contingency analysis were both used to estimate the significance and degree of association. Since no significant sex differences were evident for the 2 traits, data on males and females were combined for analysis. The tau values shown in the table indicate a consistently high correlation between Carabelli's trait and the protostylid. All of the values differ significantly from zero and, with only one exception, significance is at the 0.01 level. The


Abstract The established dogma in radiation sciences that underlies radiation protection and therapeutic applications is that radiation effects require induction of DNA damage only in cells that are directly hit by the radiation. However, extensive work during the last decade demonstrates that DNA damage responses can be detected in cells that are only bystanders. Such effects include cell killing and responses associated with DNA and chromosome damage. Here, we developed a strategy for investigating bystander effects on chromosomal integrity by premature chromosome condensation using hybrid cell formation between nontargeted human lymphocytes and targeted CHO cells or vice versa. We reasoned that signaling molecules generated in the targeted component of the hybrid will transfer to the nontargeted cell, inducing damage detectable at the chromosomal level. The results indicate that bystander cytogenetic effects between CHO and human lymphocytes cannot be detected under the experimental conditions used. This may be due either to the lack of communication of such responses between the components of the hybrid or to their abrogation by the experimental manipulations. These observations and the methodology developed should be useful in the further development of protocols for investigating bystander responses and for elucidating the underlying mechanisms.


Magnetic eld of the planets and stars can be thought of as a dipole eld in good approximation. Motion of a charged particle in the eld of magnetic dipole has been investigated in details since 1907. In particular, the Earth magnetic eld was studied by Størmer [1,2]. Solution of equation of motion for charged particle in a dipolar magnetic eld gives trapping regions for particles, with energy of limited range. These regions of planets are known as radiation belts [3,4]. The rst theoretical studies on the properties of the trajectories of charged particle in a dipolar eld are presented in [1, 5, 6]. There are also well known bodies, for which direction of magnetic moment is di erent from the direction of axis of rotation. In this case there is an electric eld around the body induced by magnetic eld. The neutron stars and pulsars are examples of such bodies. Some models of electric eld which is generated in the neighbourhood of neutron stars were developed in [7]. All these models are based on suggestion that the neutron star is a conducting body. But there are also celestial bodies, which consist of non-conducting matter and their axis of rotation is inclined with respect to the magnetic eld axis. Magnetic eld of such objects can be in good approximation described as the eld of inclined rotating magnetic dipole. In this paper we present calculation of the eld of rotating magnetic dipole and we consider also equations of motion of a charged particle in this eld. It is shown that each stationary point of the e ective potential energy corresponds to particular solution of equations of motion for a charged particle.


Abstract This research emphasizes on the importance of having an alignment of organizational strategy (innovation and imitation) with supply chain organizational learning, and Islamic HRM practices toward Batik MSMEs performance in Pekalongan, especially environmental, social, and religious performance. The population of this research is Batik MSMEs in Pekalongan, Central Java, Indonesia. Pekalongan is known as the City of Batik and has religious society that can live in peace although they live side by side with different religion and ethnicity. The respondent of this research is Batik MSMEs owner/manager in Pekalongan City that is counted using purposive sampling technique about 170 respondents. The statistic technique is using Euclidience Distance Regression. After organizational strategy being tested separately, it is proved that there is an alignment between organizational strategy both innovation and imitation with innovation organizational learning and imitation organizational learning. There is also an alignment of organizational strategy both innovation and imitation in innovation Islamic HRM Practices and conservative Islamic HRM Practices. The theoretical implication in this research provides a theory contribution about the importance of alignment of organizational strategy with the contingency of supply chain organizational learning and Islamic HRM practices. The managerial implication is that while improving organizational performance, organization needs to have practical policy in the alignment of organizational strategy with the contingency of supply chain organizational learning and Islamic HRM practices.


In this paper, we study the importance of spectral sensitivity functions in constructing discriminative representation of hyperspectral images (HSI). The main goal of a such representation is to improve image content recognition by focusing the processing only on the most relevant spectral channels. The underlying hypothesis is that for a given category, each image content is better extracted through a specific set of spectral sensitivity functions. In this study, we fixed the number of spectral sensitivity functions to 3 for displaying purposes. Deep features are then extracted from the obtained trichromatic representation of HSI data to build a discriminative image signature. Finally, spectral sensitivity functions are compared in a Content-Based Image Retrieval (CBIR) paradigm. Exhaustive experiments have been conducted on a hyperspectral dataset. Obtained results show the usefulness of the whole spectrum to obtain a discriminative image representation compared to the RGB representation.


We discuss the extent and characteristics of the internationalization of world-wide inventive activity between 1990 and 2006 using a novel set of sectoral patent-based indicators. We carry out the analysis separately for five broad technological areas, so as to appreciate differences cross-country, cross-technology, and their evolution in time. The observed level of internationalization of inventive activities varies importantly across both technologies and countries, and it has increased in time in all sectors and in most countries. Compositional effects, which derive from changes in the relative shares of the technological sectors, generally play a positive but modest role in explaining the observed aggregate increase in internationalization. A novel indicator, named "applicant surplus", allows to appreciate the presence of systematic asymmetries in how countries participate to the production of innovation globally. Important structural characteristics of internationalization differ both cross-country, and also, within countries, across sectors.


The invention provides a preparation method for preparing high-purity II type (+)-(S)-clopidogrel bisulfate. The preparation method comprises the following steps of: dissolving I type (+)-(S)-clopidogrel bisulfate in C1-C3 lower alcohol, adding a poor solvent, stirring and precipitating little amount of crystal, filtering and removing; and continuously stirring the mother liquor, crystallizing, filtering, vacuum-drying and obtaining the high-purity II type (+)-(S)-clopidogrel bisulfate. The product produced by the method has high purity and high yield, the technique condition is mild, and themethod is applicable industrial production.


Combined with the study of historical city map, the paper analyzes the main street networks and the spatial distribution of various architectural features of Chongqing city in late Qing Dynasty and Early Republic of China, and describes and explains its internal heterogeneity and spatial differentiation by empirical interpretation and statistics analysis, argues that the complicate inner spatial structure of Chongqing city is still a center of imperial authority imposed a unified form plan to a varied landscape, a kind of restricted freedom.


Advances in lidar and radar technology have potential for providing new and better information on climate significant parameters of cirrus. Consequently, the NOAA Wave Propagation Lab. is commencing CLARET (Cloud Lidar And Radar Exploratory Test) to evaluate the promise of these new capabilities. Parameters under study include cloud particle size distribution, height of cloud bases, tops, and multiple layers, and cloud dynamics revealed through measurement of vertical motions. The first phase of CLARET is planned for Sept. 1989. The CO2 coherent Doppler lidar and the sensitive K sub a band radar hold promise for providing valuable information on cirrus that is beyond the grasp of current visible lidars.


A differentially expressed EST fragment was discovered in the SSH library of Bombyx mori near isogenic line with fluoride endurance.Full length cDNA of this gene named as Asp(GenBank accession No.JX312360) was cloned by RACE method using midgut cDNA of Bombyx mori larvae from the population of near isogenic line with fluoride endurance.Full-length cDNA of this gene was 868 bp long,including 20 bp 5′-UTR and 77 bp 3′-UTR.Its ORF was 771 bp long and coded for 256 amino acids.This gene was composed of 4 exons and 3 introns.Its encoded protein was an alkaliphilic protein,belonging to the serine protease family.The protein had a cleavage site of signal peptide between the 17th and 18th amino acid residues.Real-time PCR revealed that this gene was expressed in all tested tissues including midgut,fat body and Malpighian tubule of Bombyx mori larvae from the population of near isogenic line with fluoride endurance.The expression level of Asp was the highest in midgut.Its expression level varied with the sensitivity of individuals to fluoride.In midgut,the expression level in sensitive individuals was 2.49 times to that in endurant individuals.In fat body,the expressional difference was not significant between sensitive and endurant individuals.In Malpighian tubule,the expression level in sensitive individuals was 8.16 times to that in endurant individuals.The expression level of Asp gene was obviously different in midgut of the 5th instar larva of various silkworm varieties with different fluoride endurance ability.The expression level in the fluoride resistant silkworm variety was 50 times to that in the fluoride sensitive variety.These results suggest that the alkaliphilic serine protease gene is associated with endurance to fluoride in Bombyx mori.


The goal of the paper is to present in a brief digest of the basic points of Masaryk's concept of religion and above all to point at his relationship to Christianity. The text presents the most significant life, social, philosophical and religious influences upon Masaryk's thought and it gives notice to some less stressed connections that formed his attitude to the Christian faith. One part of the paper is also a sufficient mapping of opinions and critical assessments of other authors of his time as well as contemporary ones that gave heed to Masaryk´s theory of religion.


An experimental study of the interaction between high-temperature molten materials and structural concrete is described. The experimental efforts focused on the interaction of melts of reactor core materials weighing 12 to 200 kg at temperatures 1700 to 2800/sup 0/C with calcareous and basaltic concrete representative of that found in existing light-water nuclear reactors. Observations concerning the rate and mode of melt penetration into concrete, the nature and generation rate of gases liberated during the interaction, and heat transfer from the melt to the concrete are described. Concrete erosion is shown to be primarily a melting process with little contribution from mechanical spallation. Water and carbon dioxide thermally released from the concrete are extensively reduced to hydrogen and carbon monoxide. Heat transfer from the melt to the concrete is shown to be dependent on gas generation rate and crucible geometry. Interpretation of results from the interaction experiments is supported by separate studies of the thermal decomposition of concretes, response of bulk concrete to intense heat fluxes (28 to 280 W/cm/sup 2/), and heat transfer from molten materials to decomposing solids. The experimental results are compared to assumptions made in previous analytic studies of core meltdown accidents in light-water nuclear reactors. Amore » preliminary computer code, INTER, which models and extrapolates results of the experimental program is described. The code allows estimation of the effect of physical parameters on the nature of the melt/concrete interaction.« less


Fragmentation of particle aggregates helps regulate carbon sequestration in the ocean Oceans play a critical role in Earth's carbon cycle. Quantifying essential processes in carbon cycling and extending these to future predictions remain great scientific challenges. Nearly 30% of anthropogenic carbon is absorbed from the atmosphere into the ocean, where sempiternal, ubiquitous populations of microscopic particles transport carbon into the isolated deep sea (1). This complex pathway is driven by various biophysical and chemical interactions, including phytoplankton productivity, zooplankton grazing, oceanic mixing and turbulence, advection, and the sinking of particles and aggregates (2) (see the figure). On page 791 of this issue, Briggs et al. (3) quantitatively describe the key role of particle fragmentation in carbon storage by the ocean, potentially accounting for half of the particle flux that fails to sink into the deep ocean.


This is a general discussion of the "toxic terrors" (1) Love Canal and Hinkley, California, and a more specific, in depth, evaluation of the extent and the significance of the industrial and petrochemical cancer risks to the people of Louisiana in the so-called "Cancer Alley" between Baton Rouge and New Orleans. Has the birthright been exchanged for a mess of "chemical pottage?"

"… and a great star fell from heaven, blazing like a torch, and it fell on a third of the rivers and on the springs of water. The name of the star is Wormwood. A third of the waters turned bitter, and many people died from the waters that had become bitter."

Revelation 8:10–12.

Two miles away from my house flows the Mississippi River, which swells with water from well over one-third of the rivers and streams of the continental United States.


1. Fibrous dysplasia of bone includes monostotic lesions, polyostotic lesions, and Albright's syndrome.

2. The basic morphology of all three groups includes replacement of cortical and cancellous bone and marrow by fibrous connective tissue, containing varying amounts of imperfect cancellous bone.

3. The etiology and pathogenesis of fibrous dysplasia of bone are still obscure.

4. The diagnosis may sometimes be made on the basis of clinical and roentgenographic examinations, but often a biopsy is necessary to differentiate from other conditions.

5. Treatment consists in reduction and immobilization of pathological fractures, correction of deformities, and surgical excision of painful lesions, whenever possible.


Wavelet transformation was applied to resolve overlapped chemical signals.By the use of wavelet convolution,the positions of overlapped signal peaks were accurately resolved and determined,even when the S/N ratio was relatively low,while it was not achieved by the method of 2nd derivation.In the further treatment with wavelet filtering,the peaks were clearly separated from the baseline with no change in peak positions and peak areas.Both the algorithms of wavelet convolution and wavelet filtering were applied to the testing of alcohol mixture containing ethanol,2-propanol,1-propanol,1-butanol,1-pentanol and 2-octanol,mixture of butanone and butanal,as well as the single-componental butanone and butanal.As proved by experimental result,algorithm of wavelet transformation was an effective way to resolve the overlapped signals and making the determination very satisfactory


Headache is defined as pain in the head or upper neck. It is one of the most common locations of pain in the body and has many causes. It ranks amongst the most common local pain complaints and may be frequent for many people. (1) This is the research for the treatment of tension-type headache by systematically designing a portable head massager which is ergonomics, portable, reliable user friendly, affordable and practical. Tension-type headaches account for nearly 90% of all headaches. Approximately 3% of the population suffers from chronic-tension type headache. (2) The head finite symptoms or headache normally can be solved through massaging process. Massage can bring about improvements in the health of people with a wide range of problems including stress-related conditions such as headaches.(3) The research scope will be until a stage of concept design, complete with 3D solid modeling data developed using CAD tools. Primary outcome from this research was the concept design of portable head massager complete with proposed and selected mechanical element inside it.


We developed a consumer-friendly interface graded-index plastic optical fiber (GI POF) cable with the ballpoint-pen interconnects for uncompressed 4K/8K video transmission of 120 Gb/s. Since the material dispersion of perfluorinated GI POF is smaller than that of silica multimode fiber (MMF) at 850-nm wavelength, the bandwidth achieved by GI POF is higher than that of silica MMF. Moreover, it is confirmed that by using GI POF with larger-scale microscopic polymer heterogeneities, serious noise problems observed in silica MMF are much improved by GI POF, which is achieved by resulting stronger mode coupling. This suggests that thinner 4K/8K cables can be feasible by using multilevel transmission through the low-noise GI POFs. The high-speed and low-noise GI POF is paving the way for consumer applications of 4K/8K optical interface toward the 2020 Tokyo Olympics and Paralympics.


Sets out guidelines for the teaching of pharmacognosy at Zaporozhye State Medical University for credit-modular system, which contributes to students' motivation to learn throughout the training period. The use of modern information technologies in teaching Pharmacognosy.


The utility model relates to packing box for river crabs, in particular to a packing box which can keep river crabs complete and fresh. The packing box for river crabs uses degradable plastics as raw material, which mainly comprises a box cover, a baffle cover and a box body. The baffle cover is provided between the box body and the box cover, draught holes are arranged on the baffle cover, box cover, box body and baffle cover, each river crab is put on the upper or lower layer, and the river crabs can not be squeezed; two river crabs are put in the packing box on one third position downwards of the baffle, and one river crab is put in the packing box on one third position upwards of the baffle; therefore, the refreshment effect is good and river crabs can be kept complete and fresh.


Objective To investigate the clinical value and feasibility of reserving intercostobrachial nerve(ICBN) during modified radical mastectomy for breast cancer.Methods From January 2007 to January 2010,a total of 126 cases with Ⅰ-ⅢA stage breast carcinoma were treated using modified radical mastectomy in our department and their data were analyzed.The intercostobrachial nerve(ICBN) was successfully reserved in 93 patients(the reserving ICBN group),and 33 patients could not reserve ICBN(the nonreserving ICBN group) because of lymphadenectasis,lymph node synechia and immobilization,and ICBN attached or invaded by tumour.The follow-up duration was 1-12 months.Comparison of dysaesthetic in chest wall and upper arm of affected side at different time(Chi-square test) and lymph node resection(t test) between the two groups was done.Results All patients were followed up.The mean time of operation was(125±12) min in the reserving ICBN group and(115±11) min in the non-reserving ICBN group.Lymph nodes resected was 19±3 in the reserving ICBN group and 17±2 in the non-reserving ICBN group,with no statistical difference between the two groups(P0.050).The incidences of dysaesthetic in chest wall and upper arm of affected side at one,three and 12 months after operation were all much lower in the reserving ICBN group than in the non-reserving ICBN group(P0.050).During the follow-up no local recurrence or distant metastasis was found in both groups.Conclusion Modified radical mastectomy with reserving intercostobrachial nerve for breast cancer can significantly decrease the incidence of dysaesthesia on the chest wall and upper arm of breast cancer patients after operation.The operation time can not be prolonged much and recurrent risk can not be increased using rational dissection approach.


A methodology for analytical prediction of priming surge water hammer pressures has been developed and applied to the design and development of a number of spacecraft applications. The approach involves deriving and solving equations of motion for the fluid as it surges into a downstream manifold and impacts locations in the feed system. The technique has been validated using results of testing where actual measurements of water hammer pressures were obtained. It offers increased accuracy over simpler calculation techniques, and can provide acceptable accuracy in many cases without resorting to complex fluid codes. Results of these analyses have been used to confirm component and subsystem acceptability, determine the need for surge suppression, and guide the formulation of verification testing. Some lessons learned from use of this analytical method are presented, as well as limitations and precautions associated with its use.


To analyze the effects of patent policy on growth and inequality, this paper develops a quality-ladder model with wealth heterogeneity and elastic labor supply. The model predicts that strengthening patent protection increases (a) growth by stimulating R&D and (b) income inequality by raising the return on assets. Elastic labor supply creates an additional effect on income inequality. As for consumption inequality, the effect is ambiguous and depends on the elasticity of intertemporal substitution. Calibrating the model to US data shows that strengthening patent protection increases income inequality by more than consumption inequality, and this pattern is consistent with the data.


In computer vision, object boundary is defined as the enclosed set of edge pixels by which an object is tightly surrounded. Given the object boundary, the shapes, and locations of the objects in an image can be easily recognized. However, object boundary detection is still a challenging problem due to the multi-scale object problem, the interference caused by the local edges with less semantic information, and the large variance of backgrounds and scenes. In this thesis, a cascaded framework is developed to improve the performance of the present edge detection algorithms in object boundary detection. Within the framework, present networks can be cascaded one-by-one and trained end-to-end to gain more semantic information from the inputs. The method has been tested in two scenes: neuronal boundary detection in Electron Microscopy (EM) images, and object boundary detection in natural images. Massive experiments and analyses show that the proposed cascaded fully convolutional networks can exactly outperform the competitors with the help of the cascaded structure.


Application layer protocol identification problem is the premise and foundation of network security monitoring, intrusion detection and other network control system. With the gradual development of network applications, new application layer protocol will produce, therefore bringing the difficulty to identify and update protocols. Although current supervised-based learning method can overcome low accuracy and high time complexity issue of traditional method, yet it is limited by the number of labeled data and also cannot adapt to the rapid updating of the application layer protocols, and it is restricted in further promotion. Accordingly, we propose a semi-supervised learning method to solve the above two issues. Firstly, we adopt Affinity Propagation (AP)clustering algorithm to cluster the mixed data which contains a small labeled data and large unlabeled data. Secondly, we use the labeled data to map the clustering result to specific network application. Evaluation shows that the proposed method is effective in both specific network applications and new protocol identification.


The utility model relates to a direct safety injection system for a reactor pressure vessel. The pressure vessel is provided with a cold pipe section and a hot pipe section. The system comprises a safety injection cold source, a safety injection pipeline and a safety injection control valve arranged on the safety injection pipeline. An inlet of the safety injection pipeline is communicated with the safety injection cold source, while an outlet thereof is directly connected on the pressure vessel and is positioned around an inlet of the cold pipe section. The outlet of the safety injection pipeline is directly connected on the pressure vessel, so that under the condition of an design basis accident or a serious accident or under the other specific conditions, the direct safety injection system can directly inject a refrigerant (such as cooling water) in the safety injection cold source into the pressure vessel without using the cold pipe section, avoids the defect that safety injection cannot be carries out due to blockage or fracture of the cold pipe section and has the advantages of safety and reliability.


Using ionspray tandem mass spectrometry the glutathione conjugate SMG was identified as a biliary metabolite of DMF in rats (0.003% of a dose of 5OOmg/kg DMF i.p.). Formation of this metabolite was increased five fold after induction of CYP2E1 by acetone, and was inhibited to 20% of control values following pretreatment with disulfrram. Generation of SMG from DMF in vivo was shown to exhibit a large kinetic deuterium isotope effect (KWKD=10.1 ± 1.3), which most likely represents the product of 2 discrete isotope effects on N-demethylation and formyl oxidation reactions.The industrial solvent N,N-dimethylformamide (DMF) and the investigational anti-tumour agent N-methylformamide (NMF) cause liver damage in rodents and humans. The hepatotoxicity of N-alkylformamides is linked to their metabolism to N-alkylcarbamic acid thioesters. The enzymatic details of this pathway were investigated. Hepatocytes isolated from BALB/c mice which had been pretreated with acetone, an inducer of the cytochrome P-450 isozyme CYP2E1, were incubated with NMF (10mM). NMF caused extensive toxicity (> 90% ) as determined by lactate dehydrogenase (LDH) release, compared to cells from untreated animals. Incubation of liver cells with NMF for 6 hrs caused 60±17% LDH release whilst in the presence of DMSO (10mM), an alternative substrate for CYP2E1, LDH release was reduced to 20±10% . The metabolism of NMF to S-(N-methylcarbamoyl)glutathione (SMG) was measured in incubates with liver microsomes from mice, rats or humans. Metabolism of NMF was elevated in microsomes isolated from rats and mice pretreated with acetone, by 339% and 183% respectively. Pretreatment of animals with 4-methylpyrazole induced the metabolism of NMF to 280% by rat microsomes, but was without effect on NMF metabolism by mouse microsomes. The CYP2E1 inhibitors or alternative substrates diethyl dithiocarbamate (DEDTC), p-nitrophenol (PNP) and dimethyl sulphoxide (DMSO) strongly inhibited the metabolism of NMF in suspensions of rat liver microsomes, at concentrations which did not effect aminopyrine N-demethylation. The rate of metabolism of NMF to SMG in human microsomes correlated (r> 0.8) with the rate of metabolism of chlorzoxazone, a CYP2E1 probe. A polyclonal antibody against rat CYP2E1 (10mg/nmol P-450) inhibited NMF metabolism in microsomes from rats and humans by 75% and 80% , respectively. The amount of immunoblottable enzyme in human microsomes, determined using an anti-rat CYP2E1 antibody, correlated with the rate of NMF metabolism (r> 0.8). Purified rat CYP2E1 catalysed the generation of SMG from NMF. Formation of the DMF metabolite N-hydroxymethyl-N-methylformamide (HMMF) in incubations with rat liver microsomes was elevated by 200% following pretreatment of animals with acetone. Co-incubation with DEDTC (100μM) inhibited HMMF generation from DMF by 88% . Co-incubation of DMF (10mM) with NMF (1mM) inhibited the formation of SMG by 95% . A polyclonal antibody against rat CYP2E1 (10mg/nmol P-450) inhibited generation of HMMF in incubates with rat and human liver microsomes by 68.4% and 67.5% , respectively. Purified rat CYP2E1 catalysed the generation of HMMF from DMF. Using ionspray tandem mass spectrometry the glutathione conjugate SMG was identified as a biliary metabolite of DMF in rats (0.003% of a dose of 5OOmg/kg DMF i.p.). Formation of this metabolite was increased five fold after induction of CYP2E1 by acetone, and was inhibited to 20% of control values following pretreatment with disulfrram. Generation of SMG from DMF in vivo was shown to exhibit a large kinetic deuterium isotope effect (KHKD=10.1 ± 1.3), which most likely represents the product of 2 discrete isotope effects on N-demethylation and formyl oxidation reactions.


Three cases are presented in which the presence of sodium caprylate dependent albumin auto‐agglutinins in the patients' sera resulted in erroneous Rh‐hr phenotyping of their erythrocytes. In the initial testing, the albumin control was negative in each case. Since one of the cases was an Rh0(D) negative individual whose red blood cells might have been classified as Rh0(D) positive, a study was made using routine Rh‐hr typing reagents from different manufacturers. Attention is drawn to the fact that Rh‐hr typings should be performed using washed red blood cell samples when serum is known to contain albumin auto‐agglutinins.


According to the WSEIAC (Weapon System Effectiveness Industry Advisory Committee) model, an index hierarchy of ground antiaircraft missile weapon system's effectiveness has been developed, and corresponding three hierarchy BP neural network was established. It is briefly concerned with the analysis of the BP algorithm, then through Delphi technique and the FAHP (fuzzy analytical hierarchy process), several groups of training samples are chosen to train the BP neural networks until the precision meet requirements. It is shown that this BP neural network limits the artificial factors when it is used to evaluate the ground antiaircraft missile weapon system's effectiveness. It was concluded that this method is scientific and creditable.


The immigration wave in the 1960s and 1970s brought scores of migrants to Europe. Most intended to work a few years in a foreign country and return to their homeland; however, poor economies in their own countries discouraged their return. At the same time, jobs became scarcer in their host countries. Several European countries today are resorting to measures designed to promote the return of migrants to their countries of origin. This paper outlines the two major options open to governments in their reintegration efforts. Option 1 requires instituting a definite reintegration policy. Public aid to promote reintegration may be provided. For example, the French give aid contingent upon the return of foreign workers in the labor force to the country of origin and not just upon their departure from the host country. Classical methods pay conpensation to the foreign worker; the problem then is to determine at what point to limit the funds. It must be decided whether or not unemployment benefits should be capitalized and whether or not to reimburse social security and old age contributions. It is also desirable for foreign workers to have access to a specialized organization which is able to advise them on setting up a project or business on their return; ideally, this organization should finance the project. Perhaps the best solution is to enlist participation of the governments of the countries of origin to make job openings known to their nationals desiring to return. Option 2 requires that reintegration be introduced into other economic and social programs. Returning foreign workers would be included as a factor in overall policy planning. Vocational training for return migrants could be proposed to job seekers as well as to dismissed workers. A portion of money used to finance housing projects could be earmarked for construction or reservation of housing in the country of origin. Bilateral vocational training programs can be addressed to nationals who want to return home. A portion of bilateral public development aid may also be used in support of reintegration projects. Finally, it should be possible to propose small development projects in the country of origin for nationals desiring to return.


A realization of the Lie algebra of the unitary symplectic group is proposed in terms of boson operators. The existence of a noncompact orthogonal group, complementary to the symplectic one, is shown. The highest weight polynomial of an irreducible representation of the latter group is constructed with the help of the former.


The main objective of reforms in India was to enhance the efficiency and performance of banks so that their economic standing also improves. In the early years of 1990's when the Government of India, opened the market through LPG, many private and foreign banks rushed to set up their business in India, as there was a gap (gap of service given by public banks and services expected). In order to pull up the socks and prepare our banking sector for this change, the Indian government started diluting its equity in Public /Private Sector Banks  from early 1990s in a phased manner. In recent years the economist and banking sector specialist witnessed that though the public bank's infrastructure and size of business is too large and have enough experience, but they are facing the problems and difficulties from the functioning of private banks. India is the largest country having many and varied financial institutions both public and private banks, who are controlled and governed by Reserve Bank of India, and Ministry of Finance.


tailed, and their omission is glaring. Trends are now emerging which conspire to alter race-class relations such that race may again emerge as a strong factor with which to contend. Increasing class stratification among blacks does not in itself suggest that racism is declining against the black community as a whole though it may mean that different strata will experience the effects of racism differently. Like a phoenix, the book has arisen and injected new life into recurrent debates over the relative importance of race and class and the merits of pursuing a &dquo;nationalist&dquo; vs. &dquo;class-based&dquo; political strategy to fight oppression.' It has suggested no clear course of action, but at least it has resuscitated the issue for the blqck community and the left to reconsider the nature of racial oppression in the U.S. This will be important. Social and political developments on the horizon suggest that the theory and politics of the '80s will have to confront the increasing significance of race.


"I've had a passion and a determination to change Washington DC but never as much as when I had three children. You look at your kids and then you look at what is going on in Washington and you want so much for them to have the same America that you've had. And I think that is why you see so many Moms and so many wives standing up and saying I have to do this for my children." Jamie Radtke, former Virginia Republican U.S. Senate candidate and former head of the Virginia TEA Party Patriots Federation, in a campaign ad on her Senate website (June 2012)Women have emerged as strong leaders in the Tea Party Movement. The two most outspoken public leaders of the Tea Party movement, arguably, are women: former Alaska Governor Sarah Palin and U.S. Representative Michele Bachmann, who founded the Tea Party Caucus in Congress. Voters in the 2010 midterm elections ushered in a record number of conservative Republican women to Congress, all of whom were endorsed by Tea Party Express, a leading national Tea Party organization, chaired by Amy Kremer.3 Women such as Kremer and Jenny Beth Martin were instrumental in the creation of some of the most hi-profile national Tea Party organizations, founding Tea Party Express and Tea Party Patriots, respectively. Some research also suggests that women dominate the organization (Skocpol and Williamson 2012) and leadership (Lo 2012) of grassroots Tea Party groups.


A procedure based on the reproducing kernel Hilbert space (RKHS) interpolation method has been implemented to produce a globally smooth potential energy surface (PES) for the 1 A′ state of the S(1D)+H2 reaction from a set of accurate ab initio data, calculated at the multireference configuration interaction level with augmented polarized quadruple-zeta basis sets and arranged on a three-dimensional regular full grid in the Jacobi coordinates. The procedure includes removing a small number of questionable ab initio data points, implementing a recently developed technique for efficiently handling a partially filled grid, and adopting a sequence of regularizations for attaining additional smoothness. The resulting RKHS PES is analytic, first-order differentiable, and fast to evaluate. Quasiclassical trajectory calculations have been performed and compared with the results based on a recent hybrid PES obtained from a combination of the RKHS interpolation in the entrance channel and Murrell–Carter (MC)-type fi...


Aim: The study objective was to examine the association of hypertension in the Lebanese population with three renin–angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin-receptor type 1 (AT1R). Methods: A total of 270 subjects (124 hypertensive vs 146 normotensive) were genotyped for ACE insertion (I)/deletion (D), AGT (M235T), and AT1R (A1166C) gene polymorphisms by polymerase chain reaction and restriction fragment length polymorphism. Results: The studied genes showed no deviation from Hardy–Weinberg equilibrium. No association could be reported with the ACE I/D polymorphism, although the D allele frequency was high (77%) in patients. AGT TT genotype prevalence was found to be lower in hypertensive versus normotensive subjects (p < 0.0001). AT1R CC and AC genotypes were significantly more frequent in hypertensive than normotensive subjects (p < 0.0001). Conclusion: The first conducted study on the RAS gene polymorphisms in Lebanese hypertensive patients demonstrated a possible association of the AGT T and AT1R C alleles with hypertension.


ONTARE. REVISTA DE INVESTIGACION DE LA FACULTAD DE INGENIERIA This paper aims to show the impact it has had to implement qua/ity systems and environmental  management  in Sma/1 and Medium Enterprises  as a result of an exploratory study in Bogota (Colombia). The Sma/1 Business promotes productive development of a country. The performance impact of  these organizations largely in compliance with  macroeconomic objectives and economic performance in promoting the welfare of society. The  implementation of  management  systems  help organizations to develop efficient processes and sorted so that faci/itate their production and operational activities.


The Tongshan copper deposit that lies in Guichi belongs to the iron and copper metallogenetic belt of the middle and lower Yangtze River reaches. As a middle - scaled deposit it has been mined for over 40 years. Its reserve is continuously decreasing, so ore-prospecting is extremely urgent. This paper gives suggestions on metallogenetic prognosis after the ore-control factors of the de- posit are analyzed.


(57) Abstract: The present invention is the following definition: natural polydispersity significantly larger becomes the average DP than the average DP of the carbohydrate composition, significantly low molecular monomers, dimers and oligomers do not contain, coloring agents, salts, proteins and the selected impurity from the group consisting of organic acids significantly not contain, is significantly such technical ribs agent solubility influence product novel fractionation polydisperse carbohydrate compositions not containing. The present invention is also in the preparation of the compositions of the present invention.


A group G is called an FC-group if every element x of G has only Ž . finitely many conjugates in G, that is, if the centralizer C x has finite G index in G. There exists a wide literature on this subject, and the w x monograph 18 can be used as a general reference. In the last few years many authors have studied the structure of minimal-non-FC groups, i.e., those groups which are not FC-groups while all their proper subgroups Ž w x have the property FC see, for instance, 2, 4, 5, 10 and the last section of w x. 18 . Clearly Tarski groups are minimal-non-FC, and hence in this investigation it is necessary to impose some additional condition in order to avoid such groups. In the above mentioned articles, it has been proved that ˇ minimal-non-FC groups having proper commutator subgroup are Cernikov groups, and that every perfect locally graded minimal-non-FC group is a


Conventionally every ECG signals are developed by ECG acquisition devices and these devices give a printout of the lead outputs. The printouts of ECG signal are analyzed by experts (cardiologists) for checking the abnormality or normality of patient health condition. But in recent years, automatic ECG processing has been of enormous focus to analyze ECG signal. Accurate measurement of ECG signal is a major requirement of quantitative ECG analysis, when the results of ECG signal analysis are to be used for clinical purposes. The accuracy with which parameters of ECG can be measured it mainly depends on the accuracy of the analysis algorithm. This paper presents an improved method of ECG feature extraction approach, based on the discrete wavelet transform (DWT) with Haar function being the mother wavelet. As wavelet transform is good representation for non-stationary signals, like ECG and dividing signal into different bands of frequency. To keep computational complexity low, Haar wavelet is chosen. The proposed algorithm is implemented using Hybrid Feature Extraction Algorithm (HFEA), as is efficient and low complexity algorithm for ECG feature extraction and classification. The proposed algorithm is also measured instantaneous heart rate using the time interval between two consecutive R-waves.


The National Highway Traffic Safety Administration's (NHTSA) National Accident Sampling System Crashworthiness Data System (NASS/CDS) collects detailed information on a sample of all police-reported motor vehicle crashes in the United States that involved passenger vehicles towed from the scene due to damage. This system's occupant injury definitions and severity levels, which are based on the Association for the Advancement of Automotive Medicine's (AAAM) Abbreviated Injury Scale (AIS), are periodically updated. This paper reports on the results of using a conversion method to equate pre-NASS-93 and NASS-93 and later injury descriptors and severities. The conversion maps each listed injury description and aspect in the NASS-93 coding manual to the injury descriptions and aspects listed in the NASS-88 coding manual. (A) For the covering abstract see IRRD 893297.


The research objective was to determine the aplication of the principles of good governance to village officials in public services in the Ciro-ciroe village, Watang Pulu district, Sidenreng Rappang district and to determine the factors that influenca it. The population of this study was 1356 people, while the research sampel used total probability sampling amounting to 92 people. Data collectiontechniques used in this study are to use observation techniques, interviews, literature study and questionnaires. The data collected was then analyzed using frequency and percentage tables.
The result sof this study indicate that the principles of good governance apparatus in the village of Ciro-ciroe Kacamatan Watang Pulu, Sidenreng Rappang Regency above, then the average percentage is obtained, namely 78,12%. So it can beconcluded that this indicatoris in the very good category. Public servants of the ciro-ciroe village apparatus Watang Pulu district Sidenreng Rappang district above, then the average percentage result it 69,83%. So it can be concluded that this indicator is in the quite good category. As for the factors that most influenca the application of the principles of good governance to village officials in public services in the Ciro-ciroe village Watang Pulu sub-district, Sidenreng Rappang district above, the average percentage result is 71,96%. So it can be concluded that this indicator is in the quite good category.


: Mesoscale marine phenomena represent important features to understand and include within predictive models, which provide valuable information for proper environmental policy making. For example the rearrangement of the organic substances, consequent to the dynamics of the water masses affected by the mentioned phenomena, meaningfully modifies the actual condition of local habitats. Indeed it may facilitate the onset of non resident living species at the expense of resident ones, eventually affecting related human activity, such as commercial fishery. Objective of this work is the detection and identification of mesoscale events, in terms of specific marine surface patterns that are observed throughout such events, e.g. water filaments, counter-currents, meanders due to upwelling wind actions stress. These phenomena can be studied and monitored through the analysis of Sea Surface Temperature images captured by satellite missions, such as Metop, and MODIS Terra/Aqua. A quantitative description of such events is proposed, based on dedicated algorithms that extract temporal and spatial features from the images, and exploit them to provide a signature discriminating different observed scenarios. Preliminary results of the application of the proposed approach to a dataset related to the southwestern region of the Iberian Peninsula are presented.


A simple method of calculating the consolidation settlement of soft subsoil improved by a floating cement-stabilised column–slab system subjected to embankment loading has been proposed, and the method has been applied to three case histories in Fukuoka, Japan. The proposed method adopts the methodology of treating a part of the soil–cement column improved layer with a thickness of Hc as an unimproved layer and calculating its compression using the properties of the soft soil only. Based on coupled finite-element analysis results using a unit cell model, two bilinear functions with variables of the improvement area ratio (α) and the improvement depth ratio (β) by the columns have been proposed to determine the value of Hc. Both the proposed method and the method currently used in Japan (proposed by the Japanese Institute of Construction Engineering (JICE)) were used to calculate the settlement (compression) of the soft layers for three case histories in Fukuoka, Japan. Comparing the calculated results wit...


Real clouds and cloud systems are inherently three-dimensional (3D). Because of the limitations in computer resources, however, most cloud-resolving models (CRMs) today are still two-dimensional (2D, see a brief review by Tao 2003). Only recently have 3D experiments been performed for multi-day periods for tropical cloud systems with large horizontal domains at the National Center for Atmospheric Research, at NOAA GFDL, at the U. K. Met. Office, at Colorado State University and at NASA Goddard Space Flight Center (Tao 2003). At Goddard, a 3D Goddard Cumulus Ensemble (GCE) model was used to simulate periods during TOGA COARE (December 19-27, 1992), GATE (September 1-7, 1974), SCSMEX (June 2-11, 1998), ARM (June 26-30, 1997) and KWAJEX (August 7-13, August 18-21, and August 29-September 12, 1999) using a 512 by 512 km domain (with 2-km resolution). The results indicate that surface precipitation and latent heating profiles are similar between the 2D and 3D GCE model simulations. However, there are difference in radiation, surface fluxes and precipitation characteristics. The 2D GCE model was used to perform a long-term integration on ARM/GCSS case 4 (22 days at the ARM Southern Great Plains site in March 2000). Preliminary results showed a large temperature bias in the upper troposphere that had not been seen in previous tropical cases. The major objectives of this paper are: (1) to determine the sensitivities to model configuration (i.e., 2D in west-east, south-north or 3D), (2) to identify the differences and similarities in the organization and entrainment rates of convection between 2D- and 3D-simulated ARM cloud systems, and (3) assess the impact of upper tropospheric forcing on tropical and ARM case 4 cases.


The present invention relates to an efficient whitening toothpastes scouring and its manufacturing method, its wt% of the toothpaste prepared from the following raw materials: nano-fine silica 30 to 40, 10 to 15 native glycerol, sorbitol 18 to 30 , hydroxymethyl cellulose, 0.5 to 1.2, 0.1 to 0.3 hydroxyethyl cellulose, sodium lauryl sarcosinate 1.5 to 2.5, 0.01 to 0.1 enzyme, whitening particles 1.5 ~ 5, EDTA-2Na 0.1 ~ 0.3, citric acid zinc 0.5 to 3.5, pure propolis 0.3 to 0.8, 0.5 to 0.8 strontium chloride, sodium saccharin 0.2 ~ 0.3, D- panthenol 0.8 to 1.0, 0.8 to 1.2 perfume, balance deionized water; the toothpaste according tooth yellow pigment, Causes of the respective plaque, tartar, tea scale, smoke stains, using a "synergistic effect (sYNERGY)" principle, selection of four safety scouring whitening component of the composite preparation, not only greatly improve the whitening effect, and It will not damage the enamel.


In the United States adverse reproductive outcomes are often understood in terms of Black and White differentials within the context of US‐centric racism and as an afterlife of slavery. Yet similar racial variances in outcomes are found globally. How might we understand the persistence of adverse reproductive outcomes among Black women compared to White women in transnational contexts? Building on the concept of uneven development, this article uses the framework of uneven reproduction as one way to examine how inequalities are seared on reproducing bodies. Such framing shifts the analysis of adverse reproductive outcomes from a narrow view of racial disparities to one that explains those outcomes because of complex patterns of investment and disinvestment that reconfigure reproduction. In framing reproductive outcomes as uneven reproduction, this paper excavates three distinct historical cases in three geographic areas. Drawing from imperial and colonial contexts we can track different forms of disinvestment that were and continue to be detrimental to Black women.This approach serves as a lens against which to read the persistent racial differentials in reproductive outcomes facilitated by a transhistorical, transnational and intersectional understanding of the constraints that impede Black women's successful reproduction over time and across space.


The title compound, C18H19NO2, was synthesized by the substituted one-carbon unit transfer reaction of 4-(2-aminoethyl)phenol with an imidazolidine derivative. In the crystal structure, the molecules are packed together by intermolecular O—H⋯O and N—H⋯O hydrogen bonds into layers. The different layers are stacked together by π–π interactions with a centroid-to-centroid distance of 5.836 A between 4-hydroxyphene groups in adjacent layers.


In this study, finite element method is used to investigate crack propagation of stiffened aluminum panels repaired with composite patches. For this purpose, 3-D crack-front in general mixed-mode conditions is considered for the analyses. The cracks are considered to be near the stiffener around a rivet and are capable to propagate under a cyclic loading. Effects of rivets distances and their diameter on the crack growth life of repaired panels are investigated. Moreover, the obtained crack-front shapes at various crack growth steps, crack trajectories and life of the unrepaired and repaired panels with various glass/epoxy patch lay-ups are discussed.


This paper suggests that contemporary economics is characterized by three key features. First, it is focused on "big questions" in political economy and is willing to look outside economics to search for these questions and their answers. Second, contemporary economics is empirically focused. "Grand theory" has taken a back seat to empirical explorations of institutions in particular. Third, modern economics has been dramatically influenced by "freakonomics" - the application of economic principles to unusual and unorthodox topics - and is increasingly directed at a popular lay audience. We argue that these particular areas of modern economics' evolution are not unrelated. The development of each key feature is connected to the others.


peals for the District of Columbia, speaking through Judge Bazelon and with the concurrence of Judges Edgerton and Washington, directly and unequivocally repudiated the classic M'Naghten test for insanity as a defense in a criminal case. Said the court: The rule we now hold must be applied on the retrial of this case and in future cases is not unlike that followed by the New Hampshire Court since 1870. It is simply that an accused is not criminally responsible if his unlawful act was the product of mental disease or mental defect.2


Pieces of metal are joined with silver material in a two stage heating process. In one application, a brazed poe rous coating of metal particles on a metal substrate of a device is formed by interposing a silver material bee tween the substrate and the particles, and placing the particles onto the substrate. The device is heated to a first temperature slightly below the melting point of the silver material, then briefly heated to a second tempera ture above 1100' C. to rapidly melt the silver material to wet the particles and substrate and to generate alloying among the silver material, the particles, and the sub strate. The device is allowed to cool to solidify the alloy and unite the particles and substrate to form a porous coating on the device. Also disclosed are a prosthetic device having a metal shaft for insertion into a bone canal, and a porous coating of metal particles brazed to the metal shaft by a silver material. A porous coating preparation to be applied to a metal substrate, including metal particles, silver material, and a vaporizable binder for initially securing the particles to the substrate is further disclosed.


This Paper reports an experimental investigation to establish the influence of ambient CO2, concentration, exposure temperature and curing duration on the rate of carbonation in concrete. The test specimens were concrete cylinders 100 mm in diameter and 200 mm high. Of the parameters investigated, the standard 28-day compressive strength f28 was found to be effectively representative of the concrete quality in several carbonation models proposed. Index test results, i.e. water absorption and sorptivity, were also incorporated to depict the effects of the surface property of concrete. The proposed models agreed well with the experimental data.


Abstract TheEscherichia coli hslVUgenes encode subunits of an ATP-dependent protease, a homolog of the eukaryotic 26S proteasome. We found that thehslUgene is required for the temperature (40°C)-sensitive phenotype of thednaA46mutant, while other soluble ATP-dependent proteases, La (Lon) and Ti (Clp), were unrelated to thisdnaA46phenotype. Disruption of thehslUgene inhibited cell growth at high temperatures. These observations suggest a specificin vivorole for HslVU protease in denatured proteins. As the absence of HslU produces minicells in M9 medium, the protease may be involved in the cell cycle regulation.


In parallel computing, an optimal graph embedding is to map nodes and edges of a guest graph onto nodes and paths of a host graph. Quadtrees are an important technique to present spatial based on the principle of recursive decomposition of space. We describe an efficient function to construct a compressed quadtree in crossed cubes topology using embedding technique. Our algorithm takes dilation as principle criteria for determining embedding efficiency.


Synthetic Aperture Radar (SAR) repeater jamming destroys the quality of SAR images and causes a large number of false alarms and missed alarms for SAR target detection. In this paper, the imaging characteristics of the jamming are analyzed for the two typical repeater jammings of SAR Interrupted Sampling Repeater Jamming (ISRJ) and Micro Motion Jamming (MMJ), and a SAR repeater jamming detection algorithm based on Circle Frequency Filter (CFF) is proposed. The feasibility of the algorithm is theoretically analyzed. Finally, the effectiveness of the algorithm is verified based on the real SAR image with jamming.


e18537Background: In the current era of human papillomavirus (HPV)-related oropharyngeal cancer and decreasing alcohol and tobacco use, the demographic factors associated with recurrent head and ne...