The subject innovation is coupled to, connected to the fixture after being fixed to a fixation fastener for the building exterior a certain length of a strong brittle materials such as stone (石材) which are mutually offset mounting a high-rise building can be constructed with easily attached gailcheung the structure , while allowing also to maximize the perfect moisture barrier and insulation effect of the high-rise building walls, as well as while the repair and replacement of the building exterior and easily, can be easily made, fixed fastener according to the shock and vibration of the building exterior a phenomenon in which the flow occurs, the present invention relates to a building exterior material retainer to be effectively prevented in the coupling fixture. The technical configuration, the fastener coupled to the upper side and the lower side of the building exterior 110 phase, building, such as a stone, which projects to the lower side casing 110 and the building exterior 110 'is installed inside a constant depth therebetween of groove 120 is formed, the fastener engaging groove 120, an inner side is fixed to the cross-section of the interpolation the bent portion 131 of the fixed fasteners 130 for being bent form as b, the fastener 130 for the fixed the rear is formed with a threaded portion 132, the upper and lower casing 110, 110 'of one of the threaded portion 132 of the fixed fasteners 130 for securing the connecting casing has an inner surface to be tightly interpolation inside the coupling groove 140 of the connecting fixture 150, which threaded portion 141 is formed, the outer surface threaded portion 142 of the connecting fixture 150 is formed in the casing (110) (110 'rear screwing portion 132 of the fixed fasteners 130 for connecting the other one) is a As a connecting fixture 150, the outer threaded portion 142 located coupling bolt 160 is in, combining the rear screwing portion 132 of the connecting clamp (150) securing the fastener 130 for the location in the inner and outer integrally is fixed, the connecting fastener 150 to be installed ever fixed contact as the vertical coupling piece 170, the structure 190 and the bolts 200 are formed vertically on its rear end by a base. Building exterior, connecting fastener, the fastener, screwing the fixing portion, the vertical coupling pieces


In this study, composite nanofibers of polyaniline doped with dodecylbenzene sulfonic acid (PANI-DBSA) and polyurethane (PU) were prepared via an electrospinning process. The morphology, diameter, and structure of the electrospun nanofibers were investigated. SEM images showed that the morphology and diameter of the nanofibers were mainly affected by the weight ratio of the blend. The average diameter of the nanofibers was 370–1620 nm. The diameter gradually decreased with increasing PANI-DBSA content in the blend, and more beads were obtained in the composite.


Background: Seborrheic dermatitis (SD) is a common skin disease in Iraq, which is due to various causes, the most important of which are fungal infections. The current study aims to isolate Malassezia spp., which may be a risk factor for SD, with the evaluation of some cellular parts of those yeasts, such as GM and BDG, that may play a role in the severity of this disease or its development, as well as evaluating the role of some immunological indicators, such as IL-17A, IL-8, IL-1alpha, histamine, and Cathepsin. Methods: The current study included the collection of 50 samples from patients with SD, the Malassezia species were diagnosed laboratory by microscopic examination, culture media and biochemical tests. BDG and GM were determined by Fungitell assay while histamine, cathepsin S, IL-17A, IL-8, and Il-1alpha were determined by ELISA. Results: Our results showed that most of the patients were female (68%), and they were within the age group of 16-30 years. We also found that the highest rates of infection were 34%, 22% and 20% due to the Malassezia globosa, Malassezia sympodialis and Malassezia furfur. Moreover, we determined an increase serum level of IL-8, IL-17A and IL-1alpha in patients (78.31,789.22 and 97.42 pg/ml, respectively) compared with healthy control group (0.823, 1.09 and 5.41 pg/ml, respectively) and we also found statistical differences as a result of an increase in some biochemical compounds in patients represented by histamine and cathepsin S (156 and 1190 ng/ml, respectively) and we also found an increase level for fungal compounds such as BDG and GM in SD patients where their average was 500 and 4.91 pg/ml, respectively. In conclusion: Malassezia globosa is one of the most important causes of SD, so BDG, GM, histamine, cathepsin S, IL-17A, IL-8, and IL-1alpha indicators can be relied for diagnosis and response to treatment of SD.


European Organisation for Research and Treatment of Cancer 50th Anniversary Conference: 50 Years of Progress Against Cancer Brussels, Belgium, 15–16 March 2012 The European Organisation for Research and Treatment of Cancer (EORTC) 50th Anniversary Conference was held on the 15–16 March in Brussels, Belgium. More than 1100 participants (including EORTC members and staff, national research organizations, health authorities, patient advocacy groups, European Commission, cancer leagues and the pharmaceutical industry) registered for this conference that offered a unique opportunity to gather all the partners involved in the EORTC mission. The EORTC has been a pioneer in promoting multidisciplinary cancer research in a pan-European setting with a mission to improve the standard of cancer treatment for patients with cancer. This conference highlighted the tremendous progress that has been made over the past 50 years and pointed to the challenges that will be faced in the future.


A simple interpolation formula is given to compute the pole locations of an all-pole filter whose phase is linear in the Chebyshev sense. The interpolation formula gives good results for filters with 2-10 poles and peak phase errors between 0° and 1°. Fair accuracy is achieved for peak phase errors up to 5°.


PBL teaching mode and PLTL teaching philosophy had the same consistent.The basis of both were all cooperative learning and the emphasis were on capacity-building.By summarizing the experience and measures of PBL+PLTL teaching mode in stage of clinical training for students past three grades of gynecology and obstetrics in our hospital.It was feasible for students during clinical study and had great advantages in improving the level of students' clinical thinking,theory and cooperative learning.So it should be advocated and spreaded.


Ion-exchange chromatography was used to examine the occurrence of glutamine synthetase (GS) isoforms in leaf tissue of 18 species of coastal plants. Two groups of species were recognizable on the basis of their complement of GS isoforms. One group comprised those species which exhibited two forms of GS, the properties of which were consistent with their being cytoplasmic and chloroplastic isoforms. In the second group were species which had only a single isoform, and exhibited properties similar to those of the chloroplastic isoform. Immunoprecipitation studies with antibody raised to the cytoplasmic isoenzyme of barley were carried out to identify the isoform present in species having only one peak of activity on ion-exchange chromatography. No relationship was evident between either total GS activity or the occurrence of the cytoplasmic isoform and the photorespiratory capacity of different species.


Review(s) of: Memoirs of a slow learner (an intimate personal and cultural memoir), by Peter Coleman, Angus and Robertson, 1994.


Despite the advantages of advanced high strength steels (AHSS), their stamping into functional lightweight parts demands prolonged die life, which necessitates the use of alternative substrates, coating materials, and/or surface conditioning to minimize and delay the die wear. In order to avoid frequent die replacement and surface quality problems on the stamped parts, the metalworking industry has been investigating various approaches such as reducing/refining the carbide particles, adding alloying elements, and elevating the hardness and toughness values for both substrate materials and coatings.The objective of this work was to investigate the effects of different coatings on the wear behavior of a some selected tool steel materials (die sample of interest) against two different AHSS sheet blanks through a cylinder-on-flat type reciprocating test method. After wear tests, both die sample and sheet blank surface were microscopically examined. Wear resistance of the slider was quantified from wear scar width measurements. Results showed that TD and CVD coated die samples performed better than the two other PVD coated samples.© 2013 ASME


Cooperation as a form of cooperation among business entities in the agrarian sector of the economy demonstrates its effectiveness, in particular in the countries of the European Union. Cooperation is based on trust. Many grant projects in Ukraine are aimed at supporting the cooperation of agricultural enterprises and other business entities in the agricultural sector since the beginning of its independence. However, until now, cooperation is not always perceived by land owners as a harmonious form of cooperation and development of their resource potential. We believe that this is more likely due to the population's mistrust of each other, which has been rooted in the mental level of Ukrainians for several centuries. We are convinced that it is necessary to develop, educate and involve all possible mechanisms that would convince society of cooperation as a promising form of business. For this purpose, the article proposes to strengthen the form of cooperation with modern information technologies, in particular to give it the effect of digitalization, to deploy an Internet platform. This Internet platform includes four key components: goods and services, investments and technology. It is proposed that each member of the cooperative should have the opportunity to order or offer any element necessary for the circulation of the established main spheres of the economy: production, distribution, exchange and consumption. The Internet platform serves as a kind of communicator between the manufacturer and the final buyer. For a harmoniously organized delivery of food products, it is proposed to integrate a logistics mechanism on the perehid-4.com.ua site, which, unlike Google Maps, offers delivery one step ahead: not to a building number, but to a physical person. Thus, the digitalization of the cooperative provides an opportunity to ensure the interests of the members of the cooperative: minimize their costs during the purchase of raw materials, search for investments, technologies for growing products, minimize the costs of delivery of finished products, search for ways to sell goods and services. The possibilities of digitalization of such cooperation make it possible to diversify the attraction of land and investment resources, in particular, residents of urban settlements can unite and invest in one or another process of agricultural production and immediately solve the problem of implementation, consumption, participate in rural (green) tourism, remotely monitor the process cultivation, fattening of resources previously invested by them.


From the Wisconsin status attainment model to rational choice, classical sociological, social-psychological, and economic theories of student educational transitions have assumed that students' expectations are positively related to their ultimate attainment. However, the growth of the college-for-all ethos raises questions about that assumption. Noting that American students' educational expectations rapidly outpaced their educational attainments, Rosenbaum (2001) argues that increasingly unrealistic expectations have perverse negative effects on the school engagement of American high school students. In this article, the authors test the relationship between student expectations and effort using data from a unique longitudinal study of student motivation and three national cohort studies. Contrary to the college-for-all critique, the authors find that educational expectations continue to have robust positive effects on student perceptions regarding the future utility of high school academics and student effort in high school. The relationship between expectations and effort is somewhat attenuated for very low-achieving students and it is weaker today than it was in 1980. Nonetheless, the authors' analyses indicate that the expansion of college expectations has had a net positive effect on American high school students' effort.


National manpower needs, length and clinical/research mix of fellowships, and incentives to attract residents to PR training, and trainees to faculty positions are important issues. We surveyed 142 American and Canadian pediatric chairpersons for their attitudes, and departmental clinical, research and economic needs related to rheumatology. A 28 item questionnaire utilized an educational psychologist, and a bio-statistician, to ensure optimal content clarity, completion speed, and statistical design. The response rate was 77% (1110/142). 71 departments had a PR, with 75% full- and 25% part-time. The chairs recruiting priority for a new full-time PR was "moderate-high" in 38%. Department size was: 15-25 MD and PhD faculty-24%; 26-40 faculty-26%; 41-75 faculty-34%; ≤76-16%; 39 Departments had 0-10% grant support of faculty salaries; 34 had 12-25%; 23 had 26-50%, and 5 had 51-80%. "Acute" disease trained chairpersons were less than half as likely to support having a PR, when compared to a chronic disease chair 65% of chairs believed an allergist/immunologist could provide rheumatic disease care only 0-25% of the time; 69% felt a rheumatologist gave a needed chronic disease/rehabilitation focus. Of interest, 54% of chairs stated that fellowships should be 3 years; another 17% preferred 4 years; all 71% desired a 50% research commitment: 31% of chairs would full/partial fund a rheumatology fellow to fill a faculty need, and 57% would provide 30-100% of initial faculty salaries (2-3 years). This survey reflects concerns about pediatric subspecialty manpower, training and research issues.


In order to improve the extensibility, flexibility and web-based interface of traditional DMS, a new design and implementation of document management system (DMS) for internet is introduced. It is based on Java 2 enterprise edition application server platform and implements the latest IETF (Internet Engineer Task Force) protocol-webDAV. It provides a distributed, multi-tiers, component-based, flexible and extensible DMS architecture and platform.


Spelling bee competitions are contests in which mostly younger speakers of English are pitted against each other in an attempt to find out who can spe


Abstract The role of the behaviour characteristic in the development of a mathematical model is examined. The maximum compactness method and the least squares method used for determining the characteristics of the behaviour of the mathematical model are compared.


Rice was the main adjunct in brewery. The varieties of rice with different quality were very rich in our country. The quality degenerated during storage. Different quality and different variety of rice had obvious effect on brewing process and beer quality.


A new approach to the initial preparation and continuing professional development of trade and industrial (TI an instructional or modular approach to instruction; use of a trainer of trainers approach to delivery; formal system of mentoring; awarding of credit for demonstrated technical expertise; collaboration among selected colleges, community colleges, secondary vocational centers, and business and industry; pedagogical and technical skills as required components of teacher preparation; and multiple levels of licensure and add-on endorsements. Attention should be given to the initial needs of three groups who are preparing or are TI graduates of appropriate content areas; and nondegreed technicians, practitioners, and specialists. Proposed changes to licensure/endorsement are as follows: three levels of licensure (probationary, professional, and master); two levels of endorsements (general cluster and technical speciality); and add-on endorsements. (YLB) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** A REVISED APPROACH TO THE PROFESSIONAL DEVELOPMENT AND LICENSURE OF SECONDARY T&I TEACHERS' U.S. DEPARTMENT OF EDUCATION Office of,Educational Research and Improvement ED TIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization originating it. 0 Minor changes have been made to improve reproduction Quality. Points of view or opinions stated in this document do not necessarily represent official OERI position or policy. Patrick A. O'Reilly F. Marion Asche Bryan K. Rowland Geoffrey S. Dean Background PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY TO THE EDUCATIONAL R RCES INFORMATION CENTER (ERIC) Traditionally, the majority of individuals preparing to teach T&I subjects in secondary schools have not completed teacher education programs similar to those designed to prepare teachers of academic subjects. However, the continuing development requirements for licensure renewal for both academic and T&I teachers have been similar. The current system appears to adequately serve the pre-service and in-service needs of academic teachers. However, differences in the subject matter, instructional setting, and backgrounds of T&I teachers require that a different approach to both pre-service preparation and in-service continuing development be initiated for T&I teachers. The following characteristics of T&I programs, delivery, and teachers should be considered in developing an appropriate teacher preparation system: 1. T&I subjects include both theory and skill development components, 2. Instruction in T&I subjects is often primarily delivered in a laboratory setting and may include an internship in a community setting, 3. Teachers of T&I subjects must maintain competence in pedagogy, technology of the subject, and applications of technology in the workplace, 4. Work experience in the occupation is desirable, and required for endorsement to teach T&I subjects, and 5. Many teachers of T&I subjects are recruited from business, industry, and the military. Two additional factors must also be considered when evaluating the viability of the present system of T&I teacher preparation. First, colleges and universities in many States are reducing their commitment to field service activities because of resource constraints. Second, teacher shortages are increasing in many T&I subject areas and localities are recruiting individuals from business, industry, and the military to fill vacancies. These persons may or may not have baccalaureate degrees. Those who have baccalaureate degrees are infrequently graduates of teacher education programs, more often their degree is in a relevant technical area. Given these considerations, a new approach to the initial preparation and continuing professional development of T&I teachers is appropriate. Desired Characteristics To best accommodate the needs of individuals desiring to become T&I teachers and the needs of the schools, the new system should incorporate the following characteristics: 1. Both pre-service and in-service teacher education should be available in a field based format, 2. An instructional unit and/or modular approach to instruction should used when possible and appropriate, 3. A trainer of trainers approach to delivery of instruction should be used in order to utilize the expertise of master teachers in secondary settings, 4. A formal system of mentoring must be included to support the application of pedagogical theory in the classroom and laboratory, 5. Credit applicable toward formal degree requirements must be given for demonstrated technical expertise, 6. The system should involve collaboration among selected universities and colleges, community colleges, secondary vocational centers/programs, and business and industry. 7. Both pedagogical and technical skills should be included as required components of teacher preparation/licensure requirements, and 8. The system should provide for multiple levels/types of licensure and for add-on special endorsements. 2 BEST COPY AVAILABLE Clientele and Their Needs Three groups exist among those preparing to be, or who currently are T&I teachers. Although all three have some common needs, especially with regard to continuing professional development, their initial needs are different. Graduates of Approved Teacher Education Programs No major changes in the system of preparing students in approved teacher education programs is anticipated although additional field experience prior to graduation would be desirable. However, formal mentoring during the initial year or two of teaching would greatly facilitate the transition from being a student to being a teacher. The primary needs of the group following initial employment are for a system of continuing professional development that emphasizes technical and pedagogical up-dating and formal opportunities to intern in appropriate business and industry settings while being awarded credit applicable toward both licensure renewal and advanced degrees. Graduates of Appropriate Content Areas Without Teacher Preparation While these individuals are often well prepared in the subject matter content, they are often without the pedagogical competence required to be effective in the classroom. Thus, the primary focus of the system should be to provide basic survival skills prior to entering the classroom, support through formal mentoring programs during their initial teaching experience, and broad general pedagogical competence. Once these initial needs have been met, this group's continuing professional development needs parallel those of graduates of approved teacher education programs. All activities required for initial and continuing licensure must be awarded credit applicable toward completion of a degree. Non-degreed Technicians, Practitioners, and Specialists A large cohort of experienced technicians, practitioners, and specialists exists which has the technical competence and work experience required to become T&I teachers but which lack a baccalaureate degree. In some instances these persons may possess an associates degree but such is not generally the case. The initial needs of this group are for survival skills prior to entering the classroom and support through formal mentoring programs during their initial teaching experience. Having achieved those objectives the system must then provide a means to develop knowledge in the theoretical foundations of education, broad pedagogical competence, and the general education courses or competencies required to complete degree programs. All activities must carry academic credit applicable toward either an associates or baccalaureate degree. The continuing professional development needs of this group parallel those of the other two groups once these objectives have been met. Regardless of the formal education background of the individual entering the profession, the goal of the system is to develop equally qualified and competent T&I teachers. Moreover, it is expected that all individuals without a degree will be required to actively pursue an associates degree and that those with an associates degree will be required to actively pursue a baccalaureate degree. All beginning teachers will be required to successfully complete a two to three year probationary period under a provisional certificate before being issued full and regular licensure. Proposed Licensure/Endorsement Changes Changes to the system of licensing and endorsing all vocational teachers have been proposed. While little change is proposed for some service areas, rather radical change will be needed if the strategic plan for restructuring secondary T&I programs is Virginia is implemented. Several factors make this an opportune time to consider major revisions in the current system: 1. Projected shortages of teachers in many technical areas, 2. Increasing numbers of mid-life career changers and persons seeking a second career following retirement, 3. Increasing local control over program content and objectives, 4. Accelerating technological change, 5. Projections of a relatively large number of retirees from the current teacher cadre over the next five years, and 6. Current consideration of restructuring secondary vocational programs using a Career Families model.


Warm Dense Matter (WDM) is a highly transient state of material between cold condensed matter and dense plasmas. In this work, we have investigated the confinement of carbon ions in the WDM regime and the emission in spectral lines for WDM copper in a range of plasma temperatures and densities using the developed collisional-radiative equilibrium model that includes the effects of dense plasma on radiative properties. The 2s and 2p orbitals and charge density of carbon ions are found to be severely distorted at near-solid density. It is observed for WDM copper that with the increase of temperature, spectral lines disappear in infrared and visible spectrum regions and appear in ultraviolet and soft x-ray regions. At temperature >5 eV and low density (<;0.1 g/cm3), a significant amount of radiation is emitted in x-ray spectral lines. With the increase of mass density of WDM copper, the change in line shapes, their broadening and shifts are observed. At mass density of ~0.1 g/cm3, the number of spectral lines is reduced, and completely disappear above solid density.


The Philippines is experiencing increased rates of adult overweight/obesity and persistently high prevalence of hypertension, but literature exploring their relationship is scant. This study examined the association between body mass index (BMI) and blood pressure (BP) among 1,824 adult women (ages 32–66 yr) using prospective data from the 1998 and 2002 waves of the Cebu Longitudinal Health and Nutrition Survey. We evaluated whether the BMI‐BP relationship was modified by age. Multivariate regression analyses were used to estimate the effect of 1998 BMI and BMI change from 1998–2002 on 2002 systolic (SPB) and diastolic (DBP) blood pressure, controlling for waist‐hip‐ratio (WHR), age, survey interval, and potential confounders. Controlling for WHR isolated the effect of BMI from that of central adiposity. Across the two surveys, mean BMI increased from 23.6 to 24.3 (t = 19.1, p<.01) and SPB increased from 113.5 to 114.5 (t = 2.7, p<.01) with no significant change in mean DBP. Adjusted regression estimates showed that BMI and BMI increase were positively and significantly associated with SBP and DBP. Compared to normal weight women (BMI<25), overweight women (BMI 25 ‐ <30) had higher SBP (7.2 mmHg, 95% CI: 5.2, 9.2) and DPB (5.4 mmHg, 95% CI: 4.1, 6.7); obese women (BMI 30) had higher SBP (12.0 mmHg, 95% CI: 8.4, 15.6) and DBP (8.3 mmHg, 95% CI: 5.9, 10.6). Similarly, a unit increase in BMI was associated with higher SBP (0.8 mmHg, 95% CI: 0.3, 1.3) and DBP (0.8 mmHg, 95% CI: 0.4, 1.1). The estimated BMI effects on blood pressure were not significantly modified by age. Gaining weight regardless of fat location increased blood pressure among adult women.


Horizontal distribution pattern and carapace size composition were derived for snow crab Chionoecetes opilio from data collected by long-line trap and Danish seine surveys conducted at 242-244m depth in the Japan Sea off Kyoto Prefecture in May 1990. Distinct difference in horizental distribution was noted between male and female crabs, while samplings were made at the same contour in depth. Estimates of dispersion of unit patchness for mature males ranged from 100 to 200m within a large schooling dispersion (600-1, 500m). Mature female crabs might dis-perse rather densely ranging from 100 to 300m within a large school dispersing over 1, 500m and immature females ranging from 100 to 300m within a large dispersion (400-900m). It is surg-gested that growth and/or maturation of snow crab may influence horizental distribution pattern, as well as seasonal aggregation. It was clearly showed that the carapace size compositions of crab were different between two catches by the trap and the Danish seine, which was mainly due to the differences in the frequency distribution of sub-legal male crab and mature female crab. The results showed that the trap has higher selectivity towards the large sub-legal crabs more than 80-90mm carapace width. Es-timated mean carapace width from two gears were 51.0, 67.6, 86.6, 106.9mm for males and 51.8, 68.7, 79.0mm for females.


Tiled modular 2D ultrasound arrays have the potential for realizing large apertures for novel diagnostic applications. Here we present the results of recent work for fabrication of a tileable 2D array module implemented using a 1–3 composite of high bandwidth PIN-PMN-PT material closely coupled with high voltage CMOS ASICs for buffering and multiplexing functions. The 2D transducer array is supported by a 3D printed conducting and acoustically attenuating interposer backing which links the array to a PCB housing the interface ASICs. A novel low temperature approach for assembly of the acoustic modules to the printed circuit board utilizing conductive adhesive is presented. The fabricated module consists of an array of 6 × 20 elements at 600 $\mu\mathbf{m}$ pitch in azimuth, and 1600 $\mu\mathbf{m}$ pitch in elevation. The combined acoustic electric assembly displayed excellent overall fractional bandwidth of 81% for the functional elements, high element yield of 93%, and had a center frequency of 3.5 MHz, and −20dB pulse length of 850 ns. The device was interfaced to a Verasonics Vantage 128 ultrasound system using an FPGA controller, and images were acquired using an industry standard tissue mimicking phantom.


A significant increase in scientific discoveries, made possible, among other things, thanks to the computing power provided by modern information technologies, occurs against the background of the lack of theoretical and methodological resources necessary for their scientific conceptualization. The situation is similar to the one that took place at the turn of the 19th and 20th centuries and became the object of reflection on the part of philosophers called emergentists. This explains the revival in our time of interest in some of their ideas, including the idea of ontological novelty, which emergent phenomena possess. Modern emergentism is positioned as a realistic teaching that aims to find access to reality in itself, before any knowledge about it, which implies overcoming the correlationism that has dominated philosophy since the time of Kant. One of the representatives of modern emergentism, Manuel DeLanda, tries to combine the position on the ontological novelty of emergent objects with the concept of individuation by Georges Kangilem, which reveals the mechanism of their occurrence and concretization in the form of individual singularities. This requires abandoning the ontology inherited from the ancient Greeks, based on the dialectic of the general and the singular, in favor of an ontology based on individual and universal singularities. The article analyzes the arguments of the supporters of the "new ontology" and concludes that, as in the case of classical emergence, modern discussions are caused by a crisis in physics, which is faced with the fact that the facts recorded during the study of the microcosm are inexplicable from the point of view of the existing theory, and therefore are really ontologically new. But it is possible that with the creation of the" new physics", these facts will cease to be emergent and will pass into the category of "others".


Although the aim of and the need for ecological restoration, and restoration ecology as its scientific base, are obvious, the field is still struggling with defining its basics. This situation, reflected by the debate about alternative terms to replace "restoration," the ambiguous self‐image as a movement, art, application, or science, and the lack of a unifying conceptual framework, results in an uncertainty about the future development of the field. In a 10‐year project, an interdisciplinary Research Training Group in Jena followed the regeneration of one degraded terrestrial and aquatic ecosystem, respectively, and suggested a conceptual model for regeneration and restoration that was derived from the shared features of the two systems. As part of the scientific discussion of this new approach, an international workshop "Present State and Future Perspectives of Restoration Ecology" was organized in Jena in November 2004. The following collection of 12 opinion papers and 1 concluding chapter reflect the discussions at the workshop and contributes to the "self‐finding" process of restoration ecology.


In their report "Independent photoreceptive circadian clocks throughout Drosophila ," Nov. 28, [p. 1632][1]), Jeffrey D. Plautz et al. demonstrate the existence of photoreceptors and independent circadian oscillators throughout the fruit fly. This elegant work is based on recording emission


Block copolymers of polylactide and poly( ethylene glycol) (PLA-PEG) were investigated as biodegradable drug delivery systems. They are defined by the differing molecular weight ratios of polylactide to poly( ethylene glycol). Copolymers containing more hydrophilic PEG than hydrophobic PLA per molecule self-dispersed in water giving spherical nonionic micelles. Purification by gel permeation chromatography gave two peaks. The first peak only formed micelles (the second was PLA-depleted). Analysis by dynamic light scattering (DLS) and transmission electron microscopy (TEM) gave diameters of IS.6nm and 18.9nm for 1.5:2 and 2:5 PLA-PEG micelles respectively.

PLA-PEG copolymers with more PLA than PEG per molecule (4:2 and 6:2 PLA-PEG) formed "solid particles" by the solvent-precipitation method. GPC purification again gave two peaks, but smaller second peaks. DLS analysis gave diameters of 15.1 nm and 20.8nm for 4:2 and 6:2 PLA-PEG particles respectively (confirmed by TEM and atomic force microscopy (AFM)).

Static secondary ion mass spectrometry and X-ray photoelectron spectroscopy showed PEG at the surface of 4:2 and 6:2 PLA-PEG in water and acetone. Stability testing to salt suggested sterically stability. Rheological measurements determined PEG chain layer thicknesses, with the thickest chain for 2:5 PLA-PEG (where PEG chain length is 5000gmol-1 compared with 2000gmol-1).

Testosterone and sudan black B (SBB), were used as "model" drugs with different hydrophobicities. Ultracentrifugation sedimentation velocity studies confirmed drug incorporation. Aromatic SBB loaded readily (≥59.0%w/w) compared with steroidal testosterone <2%w/w). Loading of testosterone esters of varying hydrophobicity into PLA-PEG particles showed little difference compared to between testosterone and SBB, suggesting that aromaticity is more significant. In vitro release studies (4:2 PLA-PEG particles/SBB) showed a small burst release, then linear release to twenty eight days.

In vivo studies in the rat, using a radioactive marker, demonstrated extended blood circulation times for PLA-PEG micelles during the three-hour study, with increased blood levels and lower liver uptake for 1.5:2 over 2:5 PLA-PEG micelles. PLA-PEG particles were directed to the liver.


In this paper we present the results of an experiment with the primary goal to assess the economic value that people attach to their private information. The private information considered in this experiment was related to the usage of online communication tools (emails and instant messaging), which would be collected by a proprietary monitoring software. People were asked to bid for the remuneration they would require for participating in such an experiment. We estimated the monetary value of private information in three general scenarios – data collected for academic research, for commercial purposes, and for governmental purposes.


We read with interest the experience of Maayan et al. describing four patients who developed clinical presentations of thrombotic thrombocytopenia purpura (TTP) within 28 days of receiving the BNT162b2 vaccine for COVID19: two de novo presentations and two clinical relapses.1 Further case reports of patients presenting with TTP following COVID19 vaccination have also been described.2– 5 Like Israel, the United Kingdom employed an early rollout of the COVID19 vaccination program starting in December 2020 using principally the BNT162b2 (Pfizer), an engineered mRNA vaccine coding for the spike protein and the ChAdOx1 nCov19 (Oxford/AstraZeneca), a modified adenovirus vector vaccine. In view of these reports, clinicians routinely treating patients with TTP were contacted as part of the UK TTP Registry network to assess for clinical events. Collaborators reviewed all diagnoses of de novo, clinical relapses, and ADAMTS13 relapses (ADAMTS13 activity <15% indicating consideration for elective antiCD20 antibody therapy) of immunemediated TTP at their centers from 1 January 2021 to 1 November 2021. The UK TTP registry is a prospective database of cases and treatment in the United Kingdom (Multicentre Research Ethics Committee: 08/H0810/54). Collaborators were asked to provide details on the patients' COVID19 vaccination status including number of vaccines, manufacturer, and the time of vaccination in relation to presentation/treatment episode. Treatment was considered as plasma exchange with or without antiCD20 therapy for de novo presentation and clinical relapse and antiCD20 therapy alone for ADAMTS13 relapses. We report on 90 patients requiring treatment for TTP at 10 hospital sites in England. A summary of these cases is described in Table 1. A total of 58/90 (64%) of these occurred after receiving one or more COVID19 vaccinations (27 [47%] ChAdOx1 Oxford/Astra Zeneca; 30 [52%] BNT162b2 Pfizer; 1 [2%] unknown) and 7/90 (8%) occurred before vaccination. Nineteen of 90 (21%) patients with either new presentations or relapses of TTP had chosen not to be vaccinated against COVID19. The median time from vaccination to presentation with TTP requiring treatment was 87 days (interquartile range 32– 120 days). Ten of 58 (17%) occurred within 28 days of receiving COVID19 vaccination. Of those who presented within 28 days of vaccination, five were following first vaccination and five were following second vaccination. Four of these 10 cases were new presentations, one was a clinical relapse, and five were ADAMTS13 relapses. There was no difference in cases according to vaccine type. We also assessed if the timing of de novo presentations and relapse episodes correlated to the vaccination program rollout. There was a peak of de novo presentations in October 2021 (n = 11), with a median number of cases of 3 per month (range 1– 11 case per month). There was a peak of relapse episodes in September 2021 (n = 5), with a median number of cases of three per month (range 1– 5 case per month). Nationally, the highest rates of administration of first COVID19 vaccinations were from January to March 2021 and of second vaccinations between March and June 2021.6 Comparably, a peak in presentations was not seen in relation to these vaccination peaks in either de novo presentations or relapses of TTP. The proportion of de novo, clinical relapses, and ADAMTS13 relapses from the first half of the year (January– May 2021) were similar to those in the second half of the year (June– November 2021) (21%, 2%, and 9% vs. 38%, 5%, 14%, respectively; df = 5, χ2 = 1.50, p = .47). Recognized immunemediated complications of COVID19 vaccinations are vaccineinduced thrombotic thrombocytopenia, GuillainBarre syndrome, MillerFisher syndrome, and exacerbations of immunemediated thrombocytopenia (ITP).7,8 Previously, vaccination administration to other pathogens has not been recognized as a trigger factor for ITP in populationbased analysis.9 Recognized conditions associated with TTP are pancreatitis, autoimmune disease, infection, pregnancy, surgery, untreated HIV, and specific drugs. Similar to ITP, other vaccines have not been described as a trigger for TTP. Maayan et al. have expressed concern that the four cases of TTP they report are temporally related to COVID19 vaccination, with two being de novo. They also highlight that there is a greater incidence of TTP cases than expected presenting in their health care system. From our UK experience, we identified four de novo presentations within 28 days of receiving vaccination in a much


Abstract Forty-one children between the ages of 6 and 11 years with a history of a mild closed head injury and 23 age-, gender-, and IQ-matched typically developing control children participated. All of the children in the CHI sample were referred for a magnetic resonance imaging (MRI) scan at 3 months post-injury and children in the CHI sample were further divided into MRI-Negative (n = 31) and MRI-Positive (n = 10) conditions according to the MRI results. Parents and teachers completed behavioral checklists at three points, including just prior to the MRI and 6 months post-injury. Prior to the MRI (Time 2), in both samples of children with a CHI, parents reported an increase in externalizing symptoms after the CHI. At 6 months post-injury (Time 3: post-MRI), parents of children in the MRI-Positive group did not report any significant changes in their child's externalizing behaviors when compared with pre-MRI, yet parents of children in the MRI-Negative group reported a further increase in externalizing behaviors. Parent attributions also changed as a function of group membership; whereas no changes were noted in the other two groups, parents of children in the MRI-Negative sample ascribed more controllability at Time 3 when compared with Time 2.


In this paper, the hand gesture of a person is being recognized and being identified that which hand is raised. This paper basically differentiates between the left and the second hand of the person. The human figure is first detected in the frame and then the skin color is taken into account to recognize the hands and the face of the person. The hands and the face are differentiated on the basis of the area and the centroid of the skin color map that represents basically the position and thus the hand, whether left or right hand. Camera is the only input device used in the process and then the captured digital image is being processed. The algorithm is being developed for both the captured and the real time images. The root algorithm that is being used in this paper is Mixture of Gaussian (MoG) for background subtraction that is an effective background mixture model for the background subtraction or foreground detection. Hence, a Human Machine Interface (HMI) has been developed by exploiting this method further.


The present paper aims to identify the relationships between academic buoyancy, well-being, and self-efficacy. It aims to develop a model of relationships between academic buoyancy (independent variable), self-efficacy (intermediate variable), and well-being (dependent variable) in a sample of (582) female students at Najran University. It adopted the academic buoyancy scale, well-being scale, and self-efficacy scale as tools of data collection. To analyze the results, IBM SPSS v.23 and Amos v.20 were used. The results showed that there was a statistically significant correlation between academic buoyancy, well-being, and self-efficacy. Moreover, self-efficacy positively affected the relationship between academic buoyancy and well-being.


In order to get the best design and fabrication scheme for revolving cutters mathematical models are established for edge design under distinct definition of spherical cutter with protruding arc revolving surface, design of groove for 2-axis NC machining, design of grinding wheel, and they are compared with each other. An important conclusion is drawed that the revolving cutter with constant pitch of screws is better than the revolving cutter of equal spiral angular in their design and manufacture.


Since 1990s along with the fast development of the computer technology and measurement instruments,the research of chemical engineering has been pushed progressively from the level of judgment by empirical regulations to the level of quantitative analysis by computer simulations. The research range of chemical engineering is extended to cover from observation and prediction of the micro-scale structure and interface to the system integration of the macro-scale equipment and plant. The principles and knowledge of chemical engineering are applied to from chemical engineering to process engineering for chemical conversion and physical transform such as in metallurgy, materials, energy source, environment, bioengineering. The scientists and engineers in chemical engineering profession are seeking the third mileage of the chemical engineering after the first mileage, unit operations, and the second mileage, transport process and chemical reaction engineering. The methodology of averaging, which is popularly used in chemical engineering, but neglects the influences of the heterogeneous multi-scale structure and interface, is the main reason of the large prediction error and the overwhelming difficulty in effective design and operation of chemical equipment. We should focus our attention on the structure, interface, and multi-scale issues, study the quantitative prediction theory and optimum control method for the multi-scale structure and interface, and establish the modeling for predicting the relationships among the multi-scale structure and interface, momentum transfer, heat transfer, mass transfer and chemical reaction. These efforts, combined with advanced calculating methods, computational fluid dynamics and computer simulation, may well solve the difficult problems in optimum control and scale-up of chemical processes and equipment, and catalyze the birth of the new mileage of chemical engineering.


Based on the partition of sample space which is constituted by symbol decision events,the approximate Bit Error Rate(BER) formula with the miss matched amplitude of the successive interference canceler(SIC) is generated from the formula of total probability and independence of the symbol decision event.The effect of the miss matched amplitude on the BER performance is discussed by the application of the approximate BER formula and the character of the error residuals incurred by the miss matched amplitude.The result shows that the BER performance of SIC would be enhanced with the decrease of the miss matched amplitude rate.Simulation results agree well with those of theoretical prediction and the increase of BER is not distinct when the miss matched amplitude rate is less than 20%.


"I sign this order not just as a President, but as a son, a grandson, a husband, and a father…." These were President Obama's opening words at the signing of the Executive Order Creating the White House Council on Women and Girls. The Council was created to "ensure that our daughters and granddaughters have no limits on their dreams…." This goal certainly seems to be consistent with liberal feminist values. Yet, theorists caution us that the legacy of patriarchal fatherhood shapes current governing institutions. This essay seeks to answer the question, how has the ideology of patriarchal fatherhood influenced the Obama Administration's approach to women's issues? Beginning with an analysis of John Locke and Sir Robert Filmer's major works, we establish the characteristics of patriarchal governance and its consequences for women, mainly inequality and diminished personal autonomy - and then establish how Filmer's notion of a fatherly leader has influenced the American presidency. This study hypothesizes that Obama's response to women's issues will be informed by patriarchy, elevating the primacy of the father, and thus infringing on women's fundamental rights and liberties. Utilizing official documents from the Obama Administration - mainly speeches, press releases, and policy statements - this study pinpoints an ideology of patriarchal fatherhood that seeks to promote "responsible fatherhood" by restoring men to their traditional roles of providers and protectors. Then we examine how this ideology has imbued Obama's approach to the issues of work-family balance, reproductive choice, and domestic violence. Implications for women's status in a liberal democracy and for the public's conceptions of the presidency are discussed.


While numerous public blockchain datasets are available, their utility is constrained by a singular focus on blockchain data. This constraint limits the incorporation of relevant social network data into blockchain analysis, thereby diminishing the breadth and depth of insight that can be derived. To address the above limitation, we introduce ETGraph, a novel dataset that authentically links Ethereum and Twitter, marking the first and largest dataset of its kind. ETGraph combines Ethereum transaction records (2 million nodes and 30 million edges) and Twitter following data (1 million nodes and 3 million edges), bonding 30,667 Ethereum addresses with verified Twitter accounts sourced from OpenSea. Detailed statistical analysis on ETGraph highlights the structural differences between Twitter-matched and non-Twitter-matched Ethereum addresses. Extensive experiments, including Ethereum link prediction, wash-trading Ethereum addresses detection, and Twitter-Ethereum matching link prediction, emphasize the significant role of Twitter data in enhancing Ethereum analysis. ETGraph is available at https://etgraph.deno.dev/.


Regional Drinking Water Company (PDAM) Tirta Binangun is one of the Regional Owned Enterprises (BUMD) in the field of water delivery services for Kulon Progo residents. PDAM Tirta Binangun also has a Bottled Drinking Water (AMDK) production program. AMDK KU needs to identify the financial feasibility of a 240 mℓ cup product. The need for business analysis is to find out whether AMDK KU can generate profits in the future or vice versa. The analysis of business feasibility used the methods of Break Event Point (BEP), Net Present Value (NPV), and Net B/C Ratio. Besides, it is necessary to take alternative corrective actions at the company for 240 mℓ cup products. The company of AMDK KU has gotten the normal BEP for the first cup production of 240 mℓ is 70,654 cartons, and the income in 6 months and 15 days is Rp 1,130,470,076. The analysis result is the company of AMDK KU, with the cup production of 240 mℓ, can be said that it had a profit. If the income and the price are increased by 10 percent, 20 percent, and 30 percent, it still will have profit. According to the NPV analysis, the products of 240 mℓ cup of AMDK KU are feasible to be done, even for 10 days later. However, the analysis result of the Net B/C Ratio, the products of 240 mℓ cup of AMDK KU is profitable because the score is Rp 1.1332. Furthermore, the PP result found in 10 months 11 days is included as a quick return on investment. The alternative action to solve the unprofitable products is by developing the product using the new innovation, product branding, a new marketing strategy, and additional investment.


This article explores the role of human factors engineering in patient safety in surgery. The authors discuss the history and evolution of human factors and the role of human factors in patient safety and provide a description of human factors methods used to study and improve patient safety. Implementation science is the study of the translation of evidence-based practices to real-world clinical environments. Implementation is measured


The giant Khazzan gas field, onshore Oman, has been on production since 2017, and currently produces ∼1.5 bcf/d of gas and associated condensate from the Cambro-Ordovician paralic Barik Formation. It covers an area of 2800 km2. Structural depth is a major uncertainty particularly on the flanks of the field which have poor well control and low structural relief. The increased water risk in these areas and the impact on the recoverable gas and associated liquid content have become key development considerations. The depth uncertainty is primarily driven by limited well control and seismic velocity uncertainty. Therefore to provide localized calibration a walkaway vertical seismic profile (WVSP) was acquired in 2022 in a vertical well to reduce the structural uncertainty via velocity model and seismic anisotropy calibration, and subsequently de-risk the resources and formulate an optimized development plan.
 The VSP was acquired using an array of eight 3C geophones and two vibroseis sources; and provided the following measurements: a) zero-offset data along the well to calibrate the vertical velocities and b) walkaway data over three depth intervals (shale prone) and along two orthogonal lines to calibrate polar anisotropy (assuming Tilted Transverse Isotropy "TTI") and azimuthal anisotropy, respectively. The VSP analysis was split into two phases: data processing and anisotropy computation. The data processing workflow included data preprocessing, time picking, 3C orientation along the ray path, 3C wavefield separation, deconvolution and migration. The anisotropy computation employed slowness-polarization methods to locally estimate anisotropy for each depth interval using a deterministic search. A probabilistic Monte Carlo inversion algorithm was also used to quantify uncertainty on the inverted anisotropy parameters. Finally, the VSP results were integrated with well logs and surface seismic.
 The VSP data quality is excellent and allowed measuring compressional and shear arrivals on both downgoing and upgoing wavefields. The large-offset acquisition allowed wide incident angles (up to 60° from vertical) to be recorded. The Markov Chain Monte Carlo (MCMC) inversion provided an accurate estimate of anisotropy due to good data quality (shear waves are more sensitive to anisotropy than compressional waves) and wide source-receiver offsets. The VSP showed significant anisotropy in the shallow section, higher than that derived from surface seismic. This is a factor that may contribute to the depth differences observed in the upper stratigraphy between seismic predictions and actuals in new wells.
 This is the first walkaway VSP in Block 61. It also represents unique information from the borehole as it improves on surface seismic low-resolution anisotropy, measuring Thomsen parameters (delta, epsilon and tilted axis) for each shale unit. The impact of horizontal stresses (azimuthal anisotropy) was also measured. The VSP added value in calibrating the shallow overburden (confirming high anisotropy) enabling reliable velocity picking in future surface seismic reprocessing activities.


By screening for mutants which could not degrade cellulose, several cellulase-less mutants were isolated from the wood-rotting fungus Polyporus adustus. Most of the mutants lacked mannanase and xylanase as well. In wild type, the level of cellulase, mannanase, and xylanase was higher when the fungus was grown in a medium containing cellulose than in a medium lacking cellulose. It is proposed that in P. adustus, the induction of this group of enzymes is under the control of a single common regulator gene.


University students have entered their puberty stage. The awakening of their natural consciousness naturally leads them to a psychologically active dating period. It is therefore necessary to analyze their behavior, eliminate their mental dilemma, and give proper guidance to them.


Congestion control is a key problem in mobile ad-hoc networks. Congestion has a severe impact on the throughput, routing and performance. Identifying the occurrence of congestion in a Mobile Ad-hoc Network (MANET) is a challenging task. The congestion control techniques provided by Transmission Control Protocol (TCP) is specially designed for wired networks. There are several approaches designed over TCP for detecting and overcoming the congestion. This paper considers design of Link-Layer congestion control for ad hoc wireless networks, where the bandwidth and delay is measured at each node along the path. Based on the cumulated values, the receiver calculates the new window size and transmits this information to the sender as feedback. The sender behavior is altered appropriately. The proposed technique is also compatible with standard TCP.


A growing body of research suggests that the beliefs, interests, expectations and other attitudes acquired early in life play a critical role in shaping individuals' career trajectories. Yet the causal pathways connecting early-acquired attitudes and future outcomes are not well understood. In this study, the authors argue that a plausible way to understand this relationship is by postulating a direct effect of early-acquired attitudes on future outcomes that is not mediated by more recent values of these attitudes. This effect is referred to as the controlled direct effect. Using a nationally representative sample, the authors implement inverse probability–weighted marginal structural models to estimate the controlled direct effect of math and science identity beliefs in ninth grade on career and college outcomes in science, technology, engineering, and mathematics (STEM). The results suggest that identifying with science or math in school increases the odds of enrolling in a STEM major in college as well expecting to have a STEM career.


: In order to ensure the territorial development of land use in the region, there is a need to change the trajectory of spatial and urban planning factors. The ways for implementation of the proposed system measures are defined in the article. For investment and environmental indicators, the integrated indicator of territorial development of land use in the region, depending on their change, is predicted. The article presents the results of forecasting the integrated indicator of land use territorial development in the region based on the growth of systemic investment factors and the results of forecasting the integrated indicator of land use territorial development based on the growth of systemic environmental factors. Practical scientific-based recommendations for ensuring the territorial development of land use in the region by applying the results of its integrated assessment and modeling are proposed. Developed recommendations made it possible to form directions and build the basis for ensuring the territorial development of land use in the region. The development of methodological recommendations for ensuring the territorial development of land use in the region is based on the results of the study of the influence of systematic spatial, urban, investment, and environmental factors on the integrated indicator of land use territorial development.


The emergence of federations of repositories, ten years ago, has supported the dissemination of scientific literature in open access. However, there is few scholarly information about these tools. Then, this study aims to present information about federations to contribute to this topic not yet explored. A qualitative study using techniques of documentary research, for the verification of concepts, policies, characteristics and trends of the federations available on the internet. The results revealed consensus in many aspects, with a collaborative scenarios and not too much studied, although it is of academic interest, in which the federation promoting the development of repositories. Thus, the study provides information on the federations, with a actual theme.


In order to optimize the preparation process of silver-loaded diatomite, the effect of the adsorption time, temperature and the concentration of silver nitrate on the content of silver ions in diatomite were investigated through ion exchange experiment method. And the antibacterial properties were measured by Haloes method. The samples were characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The results show that the loading of the silver ions is no change in the microscopic structure of the diatomite, the silver exists in diatomite as the ion. The content of silver in the diatomite is 0.523g/g under the condition of AgNO3 (0.5mol/L) and temperature 70°C. The silver-loaded diatomite has good antibacterial activity on E. coli.


The Detector for Advanced Neutron Capture Experiments (DANCE) is a 159‐element 4π barium fluoride array designed to study neutron capture on small quantities, 1 mg or less, of radioactive nuclides. It is being built on a 20 m neutron flight path which views the "upper tier" water moderator at the Manuel J. Lujan Jr. Neutron Scattering Center at the Los Alamos Neutron Science Center. The detector design is based on Monte Carlo calculations which have suggested ways to minimize backgrounds due to neutron scattering events. A data acquisition system based on fast transient digitizers is being implemented.


The Covid-19 pandemic has hit many enterprises in Indonesia, especially on the micro-small medium scale. Various kinds of Indonesian government policies in reducing the spread of the covid-19 virus are often followed by the impact of business continuity on MSMEs. Along with the implementation of that policy, many MSMEs are competing to digitalize its businesses in their buying and selling transactions. Optimization of the use of social media is used to retain old buyers and attract new markets. This study aims to determine whether optimizing and utilizing the use of social media, which focus on Instagram, maximally can help MSME in maintaining their business in the pandemic era. A qualitative approach with a 45-day observation method for selected MSMEs in Indonesia is carried out in forming some unique themes related to strengths and weaknesses that arise from Instagram utilization activity. The effectiveness of using Instagram could be obtained through several activities, such as customer engagement optimization, content highlight, and popular brand benchmarking.


Abstract Phosphorylation, Dephosphorylation, Inorganic Phosphate, Sarcoplasmic Membranes The calcium transport protein of the sarcoplasmic reticulum accepts inorganic phosphate rapidly when phosphorylation is initiated either by the addition of phosphate or m agnesium ions to the calcium free protein. Phosphorylation proceeds much more slowly when it is initiated by the addition of the calcium chelator ethyleneglycol-bis (β-aminoethyl ether) -N ,N′-tetraacetic acid (EGTA) to the phosphate and magnesium containing assay. The time course of phosphorylation following immediately calcium removal is monophasic at all temperatures between 20° and 37 0|C. In contrast, phosphorylation of the calcium free enzyme becomes biphasic at temperatures above 25 °C. The biphasic time course does not only apply to net formation of phosphoprotein but also to its exchange with medium phosphate. On addition of calcium, the phosphoprotein decays in a biphasic process the time constants of which are much longer than those observed for phosphoprotein formation. The temperature dependence of the rate as well as of the extent of phosphoprotein formation indicate a discontinuity in the reactivity of the protein.


As a model for the reaction between polyethylene films and gaseous SO3, n-hexane was allowed to react with gaseous SO3 to give 1,3,5-hexatriene-1,6-disulfonic acid (HTDS), which was isolated from the reaction products by column chromatography. Furthermore, it was found that an aqueous solution of HTDS-Na was sensitive to UV, which eliminated one of the sulfonic acid groups by a radical mechanism. sulfonic acids having less than three conjugated double bonds were not sensitive to UV.


Introduction Evaluation The What and the Why The Advantages of Collaboration Ethical and Political Considerations Designs for Different Purposes Getting Answers to Evaluation Questions Some Practicalities Communicating the Findings


Hypoxia, e.g., inadequate supply of O2 with respect to needs, is a very common condition that invariantly leads to a variety of responses, which often result into relevant pathophysiological disorders. By sensing the lack of O2 and activating at the molecular level an array of strategies, cells and organisms can however compensate and/or adapt to hypoxia. Of the several mechanisms hitherto proposed, we propose a novel one that involves the signalling path of sphingolipids, which is known to have essential importance in many aspects of cell biology, such as inflammatory processes, cell proliferation, death, migration and senescence. In this review, we summarize the main Correspondence/Reprint request: Prof. Michele Samaja, Università di Milano, Ospedale San Paolo Dipartimento di Medicina, Chirurgia e Odontoiatria, via di Rudinì 8, I-20142 Milano, Italy E-mail email@example.com Anna Caretti et al. 2 molecular mechanisms underlying O2 sensing and cellular response to hypoxia, as well as the main paradigms of the sphingolipids signalling path. Finally, we compare literature data concerning the two mechanisms and consider the possibility that there may be a cross-talk between hypoxia and the metabolism of sphingolipids. Introduction Molecular O2 is the preferred oxidizing substrate in almost every form of life on the Earth. Atmospheric O2 fluctuations in the 12-35% range over the last 600 million years have been critical to decide the actual predominant forms of life, with hyperoxia favoring the evolution of animal flight and gigantism and hypoxia leading near life extinction (1). Although the O2 fraction in the atmosphere is today stable at 20.93% irrespectively of altitude and latitude, significant gradients exist for what concerns the O2 tension (PO2), which is function of the vertical distance to sea level and can be as low as 52 mmHg on the summit of Mt. Everest (2), i.e., one-third of the PO2 at sea level. Although atmospheric O2 is a major determinant of tissue PO2, there are many local situations whereby tissues suffer a lack of O2, the main consequence of which is hypoxia, i.e., when O2 demand does not meet O2 supply (Figure 1). Figure 1. Representation of the O2 cascade during the flow of O2 from the atmosphere to the mitochondria at sea level (normal O2 content) and an hypothetical situation of hypoxia corresponding to roughly one-third reduction in O2 supply. Correct supply to the last compartment depends on the gradient maintenance at each step. There are 6 steps where inadequate O2 flow may result into hypoxia: (1) Low air PO2 due to exposure Sphingolipids and hypoxia 3 Figure 1. legend continued to high altitude or hypoxic chambers; (2) low alveolar PO2 due to respiratory failure; (3) low arterial PO2 due to poor pulmonary perfusion and right-to-left heart shunt; (4) low venous PO2 due to blood O2 transport failure; (5) low cytoplasm PO2 due to poor O2 diffusion from blood to cell; (6) low mitochondria PO2 due to inability to use O2 for biochemical blocks, inhibition or poisoning. In cells and tissues, hypoxia produces both pro-death and pro-life responses, generally depending on the severity of the stress. In the last decade, a class of bioactive lipids, namely sphingolipids, has been demonstrated to serve as executors of extracellular signals and to control cell fate. Within this family, ceramide and sphingosine-1-phosphate (S1P) are players of cell death and cell survival, respectively. A number of reports have already demonstrated the intervention of sphingolipids as mediators of the hypoxic stress, in cells and tissues, normal and cancerous. In this review, we survey the potential cross-talk between hypoxia and sphingolipid signaling, with the purpose to learn on the molecular mechanism underlying cell and tissue response to hypoxia. Hypoxia Role of O2 in aerobic metabolism Because O2 serves as the terminal acceptor of electrons in mitochondrial oxidative phosphorylation, the major reaction for generating energy in the form of ATP in all cells except erythrocytes, aerobic organisms have developed sophisticated mechanisms to guarantee appropriate delivery of O2 to cells and tissues under any condition. As ATP is the major responsible for maintaining a homeostatic intracellular environment through the ATPdependent ion pumping systems, that might consume up to 80% of the resting metabolic rate, keeping a normal ATP content is critical and any shortage in O2 supply reflects immediately into altered ATP content especially in tissues with high energy demand (3). As soon as backup mechanisms aimed at supplying ATP via non-mitochondrial paths are exhausted, which may be matter of seconds or even less, the ATP level declines causing failure of ATPases and depolarization of membranes. The subsequent Ca influx through voltage-gated Ca channels leads to intracellular Ca overload (4) and activation of Ca-dependent phospholipases and proteases, which are the main causes for hypoxia-driven cell swelling, hydrolysis of cellular components and necrosis (5). All nucleated cells can adapt, to a certain degree, to mild or short hypoxia through activation of pre-existing proteins with the aim to improve the efficiency of energy-yielding pathways and to enhance the switch from aerobic to anaerobic metabolism. First, allosteric activation of phosphofructokinase by Anna Caretti et al. 4 AMP and lactate represents a classical mechanism by which anaerobic glycolytic ATP production is increased when aerobic ATP production is hindered by hypoxia, the well known Pasteur effect (6). Although less efficient than oxidative phosphorylation in the generation of ATP, in the presence of excess glucose glycolysis can sustain the needed metabolic energy albeit for limited periods of time (7). An AMP-activated protein kinase acts as primary sensor of the cell energy charge by controlling the branch point between anabolism and catabolism (8). Second, the hypoxic cell can down-regulate energy consumption in an attempt to match the decreased ATP production by decreasing the ATP demand, phenomenon known as hypo-metabolism (9), similar to the hibernation observed in ischemic hearts (10). This mechanism, however, is more likely to occur during ischemia rather than during hypoxia (11). Third, hypoxic cells tend to reallocate ATP consumption off processes not essential for short-time survival such as synthesis of proteins and RNA/DNA (12), whereas the Na/K pumping and Ca cycling processes are preserved, phenomenon known as O2 conformance (13). For example, hypoxia may repress the mammalian target of rapamycin as if the cell was exposed to rapamycin, thereby inhibiting protein translation (14). As a matter of fact, these mechanisms prove unable to function for sustained periods of time or for severe hypoxia essentially for two reasons. First, although the activity of monocarboxylate transporters, the exporters of lactate, the final product of anaerobic glycolysis, is increased during hypoxia (15), this might not cope with increased lactate output, and almost invariably prolonged exposures to hypoxia lead to intracellular lactate accumulation with acidosis, which prevent the normal glycolytic flux and impair cell function (16). Second and most important, slower synthesis of protein and DNA/RNA prevents normal cell turnover and impairs defense against external stress. Sensing the lack of O2 Although primarily involved in essential metabolic processes, increasing evidence supports the notion that O2 plays an important role as a second messenger to regulate the response to hypoxia, thereby enabling specialized cells to function as O2 sensors, a fundamental step for triggering mechanisms aimed at hypoxia adaptation. In principle, every protein that undergoes O2dependent conformational changes can act as an O2 sensor. The O2 sensor is effective when the two conformations regulate by different extents the paths that enable defense against O2 reduction, whereas the sensitivity of the O2 sensor depends on the Km for O2 of the conformational change. It is therefore likely that in vivo more than one O2 sensing mechanisms act in parallel to cover a wide range of PO2 decreases from mild hypoxia to anoxia and to ensure that a variety of adaptive paths counteract synergistically the effects of hypoxia. Sphingolipids and hypoxia 5 Heme-containing proteins In principle, vertebrate hemoglobin has several features typical of O2 sensors, because it binds O2 at the heme Fe with a rather low Km, or P50, of 26-28 mmHg, and undergoes O2-dependent conformation changes. However, no clear second messenger action has been attributed to hemoglobin, although a possible role as NO carrier is being unraveled (17). Other heme-containing proteins have been historically the first candidate O2 sensors as from the observations that Fe chelation or substitution with Co may emulate hypoxia (18) and that CO, a ligand that binds the heme Fe with stronger affinity than O2, may lock the sensor in the oxy-conformation. A non-mitochondrial enzyme highly expressed in glomus cells of the carotid body chemoreceptors, and first proposed as O2 sensor in 1989 (19), NADPH oxidase catalyzes the univalent reduction of O2 with production of superoxide anion (O2), which gives raise to reactive O2 species (ROS): O2 + NADPH → O2 + NADP As NADPH oxidase seems to be the main ROS donor in many cell systems (20), it may act as an O2 sensor by changing the formation rate of O2. As the Km for O2 is ~20 mmHg, NADPH oxidase is effective as O2 sensor at low to intermediate PO2 (21). In addition to NADPH oxidase, microsomal mixedfunctional oxidases have also been proposed as O2 sensor in 1990, based on the observation that these O2-sensitive heme proteins play a role in the control of the synthesis of erythropoietin (22). Oxidases act as O2 sensors either by producing varying amounts of ROS as a function of PO2, or by controlling ions flux and the mitogen-activated protein kinase system (MAPK) via the


In this paper, a novel dual-polarization differential quadrature phase shift keying (DQPSK) system is proposed, which does not need polarization de-multiplexing like the conventional polarization division multiplexing QPSK, but bases on just one receiver. Its performance including the tolerance to chromatic dispersion (CD) and to polarization mode dispersion (PMD) is analyzed. The result shows that the tolerance to CD and PMD of the novel system is nearly same to that of DQPSK system with the same bit rate, but it can bring down the electrical signals rate at the transmitter.


A method is described for directly measuring interfacial contact resistance and estimating the degree of uniformity of the interfacial layer in metal-semiconductor contacts. A two-dimensional resistor network model is used to obtain a relationship between the specific contact resistance and the measured interfacial contact resistance for contacts with a homogeneous interfacial layer. Measurement results are given for 98.5% Al/1.5% Si and 100 % Al contacts on n-type silicon.


The bending angle received from low earth orbit satellites (LEO) can be used to derive the refractivity of the atmosphere. However, the information is retrieved under the assumption that the atmosphere is locally spherically symmetric. In general, this assumption has proved to be verified for a global model with moderate resolution (>120km), and assimilating Abelian retrievals as "local" refractivity profile measurements has seemed to be partly successful. This approach, however, is likely to fail with mesoscale models, where the existence of humidity gradients on short distances can severely affect the horizontal homogeneity of atmospheric refractivity. In this presentation, we report a study on the validity of the assumption of the locally spherical symmetry on the retrieved refractivity at mesoscale using an Observing System Simulation Experiment (OSSE) approach.


The largest organ in the body, the skin, acts as an immediate barrier between internal tissues and the outside world. The body is shielded by the skin from microbial and chemical attack, as well as the effects of temperature. Skin conditions have a significant impact on a person's emotional and physical health. Psoriasis is one of the most significant skin conditions that have presented difficulties for the medical community. According to Ayurvedic medicine, skin conditions are referred to as Kushta (skin diseases). Kushta comes in eighteen different varieties. The symptoms of psoriasis are comparable to those of Sidhma Kushta which are discussed under Kshudra Kushtās (minor skin diseases). Azadirachta indica (Nimbha) leaves grinded with Sesame oil was the chosen paste from a traditional formula and this review's objective was to investigate how well this selected paste manages to treat Sidhma Kushta. Information about Sidhma Kushta was acquired from Ayurvedic scriptures, contemporary texts and earlier research studies (from primary and secondary sources). Afterwards a survey of the literature was done on this paste and then examined for their Pancha Padārtha (five elements of herb) and pharmacological qualities regarding in the management of Sidhma Kushta. Ayurvedic Pancha Padārtha study has revealed that selected paste has anti-inflammatory effects. The majority of studies have demonstrated the anti-inflammatory effects of selected paste and according to a literature review and Pancha Padārtha analyze, selected paste is useful in the treatment of Sidhma Kushta.


Finite-size scaling calculations are performed for the critical dynamics of the ferromagnetic Ising model on fractal lattices. We confirm the predictions of Henley's heuristic theory of singular dynamic scaling and compare our results with those recently obtained by Kutasov et al. using Monte Carlo methods. It is found that fractal lattices which have odd coordination have an exponentially large number of metastable states but that these states do not necessarily play a significant role in the critical dynamics.


Investigation was conducted with the aim to get insight into the perception of different barriers for implementation of innovation projects by the employees in the companies in Serbia in dependence of employees' educational level, their perception of companies' innovativeness and the ownership structure of the company. Questionnaire-based research of perception of risk, finance, employees, management, social environment and information related barriers was carried out in the companies with different ownership structure: public enterprises, subsidiaries of multinational companies and companies owned by domestic entrepreneurs. In addition to the company's ownership, respondent's education level and perception of company's innovativeness were used as independent variables. The hypothesis that the perception of the barriers to the implementation of innovative projects in companies in Serbia by employees depends on the level of their education was not supported while the other two hypotheses stating that perception of the barriers to innovation projects depends on employee's perception of company's innovativeness and the ownership of the company were both supported. High level of perception of barriers in Serbia imposes the limitations to the implementation of innovation projects in Serbia, and thus case-specific activities aimed at overcoming of barriers to innovation projects should be planned and implemented.


The invention relates to a method for managing the data of a portable electronic device connected to a host machine, said device containing first data, and the host machine being connected to a remote data server containing second data. The method includes the steps of: creating in the device a unique list indicating the first and second data, transmitting said unique list from said device to the host machine.


This paper presents an assessment of the vulnerability between human activities and flood disaster for each different unit,which based on a mathematical model that taking 19 counties(cities) in Jianghan Plain as statistical unit and built a vulnerability standard system of human activity and flood disaster.After that,an analysis and a ranking of coupling are represented for the vulnerability,which based on the ArcGIS.Finally,the results show that the spatial distribution of them differs obviously and the correlativeness is good,and this shows disaster-causing effect in Jianghan Plain is obvious.


A mathematical model of the development of an oil and gas field is presented. The field development process is treated as sequential in nature. Completion of a well and its production are considered to be random processes. The model uses results from renewal theory where the completion of a well and failure to produce economical amount of oil or gas are analogous to the failure of a component. In principle, the theory described can give the complete probability distribution associated with a field development. Explicit expressions are given for the expected value and variance of the number of completed wells.


Abstract Based on the reaction of alkyl azides with organoboranes to give secondary aminesl we decided to investigate the reaction of aryl sulfonyl Azsdes with trialkylboranes as a potential stereo and regiospecific route to sulfonamides as envisioned in eq. 1. The desired reaction did not occur. Thus, when a mixture of p-tolylsulfonyl azide was reacted with tricyclohexylborane4 in re-fluxing toluene a gradual disappearance of the azide band at 2110 cm−1 in the IR was observed with a concomitant appearance of a band at 2100 cm−1 in dicating the presence of an intermediate in the reaction. Upon oxidation with alkaline hydrogen peroxide followed by purification by flash chromatography p-tolylcyclo-hexylsulfide was produced in 48% yield contaminated with very small amounts of bis-p-tolyldisulfide and the intermediate as as-certained by a small band at 2100 cm−1 in the IR (eq. 2). The intermediate could not be isolated in pure form due to decomposition to the sulfide. The results of the preparation of arylalk...


To reach a good user-friendliness, knowledge about user requirements is crucial in the development process of a product. The sooner the knowledge is achieved via user evaluations, the more money and time can be saved. In this paper we investigate an approach called hybrid simulation for the early stages evaluation of mobile applications where real mobile phones are used as interaction devices to a virtualised simulation of a pervasive environment. On the first sight, the method is cheap, easy and quick to use as well as more realistic compared to a virtual simulation only approach. In order to receive a more detailed insight in potential benefits and problems of the method, we performed a user study and compared results of a traditional laboratory study with the results of a study performed with the hybrid simulation.


This paper presents a theoretical study of the performance of GaN-based avalanche photodetectors using an ensemble Monte Carlo method. The model includes the details of the full band structure derived from nonlocal empirical pseudopotential calculations. Carrier-phonon and impact ionization scattering rates are obtained from the calculated electronic structure and from a first-principles study of the lattice dynamics. Multiplication gain, noise and bandwidth properties of back- and front-illuminated structures are evaluated by means of full band Monte Carlo simulation for different crystal orientations and multiplication region thicknesses. The simulation results indicate that hole injection in devices grown along the Γ-A direction provides the most favorable operating condition in terms of gain and noise. Finally, gain saturation effects due to electric field screening induced by photogenerated carriers are discussed.


The Myth of Communications. The Myth of the Organization Chart. The Myth of the Management Committee. The Myth of the Production Wizard. The Myth of the Almighty Dollar. The Myth of the Magic Numbers. The Myth of the Specialist. The Myth of the Cost Cutter. The Myth of the Magic Expense Account. The Myth of the Overworked Executive. The Myth of the Wicked Politician. The Myth of the Perfect Balance Sheet. The Myth of the Slick Purchasing Agent. The Myth of the Rugged Individualist. The Myth of the Communist Superman. The Myth of Retirement.


Secant piling, one kind of retaining and protecting system for deep foundation excavation, is being widely applied to metro projects for its prominent characters. After several years'practice great change have taken place on traditional Benoto cast-in-place technique. The paper will discuss new questions appeared in some project about design on piles and construction equipment. Based on engineering practice, new prollems in secant pile design and mechanical inslallation in some project is disscussed.


An experiment was conducted at Oilseed Research Station, Latur, Maharashtra, to "Studies on biology of groundnut bruchid, C. serratus (Olivier) on different groundnut varieties in storage condition" during 2017-18. Ten groundnut varieties were used for biology studies in which the lowest oviposition period of C. serratus 3.50 days was recorded on LGN-1. While the highest oviposition period (8.50 days) was observed on groundnut variety of JL-24. The shortest incubation period of C. serratus i.e. 4.00 days was observed on groundnut varieties RTNG-53 and TKG-BOLD whereas, highest incubation period of 6.25 days was observed in RHRG-1135 groundnut varieties. In case of larval emergence of C. serratus is less number of larvae emerged from JL-24 (69.75) while the highest number of C. serratus larvae emerged from RHRG-1135 (89.75). The longer larval duration of C. serratus 34.00 days was observed on TAG24 followed by JL-24 (33.00). While shorter larval duration was recorded in RHRG-1135 i.e. 24.75 days. The highest growth index was recorded on variety RTNG-53 (0.333). The lowest number larvae pupated was recorded in JL-24 (66.00). The highest number larvae pupated was observed in RHRG-1135 (85.25). The shortest pupal duration was observed on JL-24 (12.75 days). Longer pupal duration was recorded in TKG-BOLD (15.25). The lowest number of adults 57.75 emerged from JL-24 while the highest number of adults was recorded from RHRG-1135 (80.25). The highest longevity of adults C. serratus was recorded on TKG-BOLD (14.25 days). Whereas, lowest longevity adults were observed in JL-24 (12.75days).


In order to implement the co-operation and integration with information system of enterprise of different monitoring instruments,a universal monitoring framework with open system architecture for the encapsulation of monitoring instruments was introduced,and the architecture,technical characteristics and the key technology were explored.The monitoring transparency and the problem of"islands of information"were achieved through the framework.


Implant stability is important for osseointregration; without it, long-term success cannot be achieved. Continuous monitoring in a quantitative and objective manner is important to determine the status of implant stability. Measurement of implant stability is a valuable tool for making decisions pertaining to treatment protocol and it also improves dentist-patient communication. Owing to the invasive nature of histological analysis, various others methods have been proposed such as radiographs, cutting torque resistance, reverse torque, and resonance frequency analysis (RFA). This review focuses on the objectives and various methods to evaluate implant stability.


Since the first reported efficacious use of human growth hormone in 1958, numerous children have been treated with this hormone. This review discusses the five indications for use of human growth hormone in children that have been approved to date by the United States Food and Drug Administration.


May 15, 2010 – Community-Campus Partnerships for Health (CCPH) is delighted to announce the Center for Community Health Education Research and Service (CCHERS) in Boston, MA, USA as the recipient of the 9th Annual CCPH Award. The award, presented during the closing session of CCPH's 11 th conference in Portland, Oregon, USA, recognizes exemplary partnerships between communities and higher educational institutions that build on each other's strengths to improve higher education, civic engagement, and the overall health of communities. The intent of the award is to highlight the power and potential of community-campus partnerships as a strategy for social justice. It honors partnerships that are striving to achieve the systems and policy changes needed to overcome the root causes of health, social and economic inequalities.


List of Tables List of Graphs Chapter OneIntroduction Statement of the Problem The Importance of the Project Purpose of the Project Objectives of the Project Definitions of Important Terms Summary 1 4 4 5 7 7 8 8 8 9 Chapter TwoReview of Literature California State Teaching Requirements for Horticulture Advantages of Having a High School Horticulture Program Career Preparation for Students Difficulties with Horticulture in the High School Setting California Budget Issues for High Schools Fundraising and Money Saving Techniques 11 11 15 16 18 19 20 Chapter ThreeMethods and Materials Population Instrumentation Data Collection 23 24 24 28


Abstract The ET-RR-1 research reactor has been operated at 2 MW since 1961 using EK-10 fuel elements with 10% enriched uranium. The reactor has been used for nuclear applied research and isotope production. In order to upgrade the reactor power to a reasonable limit facing up-to-date uses, core conversion by a new type of fuel element available is necessary. Two fuel elements in plate type are suggested in this study to be used in the ET-RR-1 reactor core rather than the utilized ones. The first element has a dimension of 8×8×50 cm and consists of 19.7% enriched uranium, which is typical for that utilized in the ET RR-2 reactor, but with a different length. The other element is proposed with a dimension of 7×7×50 cm and has the same uranium enrichment. To accomplish safety requirements for these fuel elements, thermal-hydraulic evaluation has been carried out using the PARET code. To reach a core conversion of the ET-RR-1 reactor with the above two types of fuel elements, neutronic calculations have been performed using WIMSD4, DIXY2 and EREBUS codes. Some important nuclear parameters needed in the physical design of the reactor were calculated and included in this study.


Abstract The numerical methodology needed to convert the retention ratio, R, to the dimensionless mear layer thickness, Λ, commonly encountered in field-flow fractionation (FFF), is reviewed and a rigorous interpolation scheme which is suitable for any of the FFF techniques is presented. Computer implementation and error estimates are discussed in detail.


The purpose of the current study was that of evaluating and comparing the pharmacokinetic parameters (Tmax, Cmax, Ke, AUC, t1/2 beta) at the compounds TGA, tolmetin and MCPA obtained from healthy volunteers following a single oral administration of 600 mg of 2-methoxyphenyl 1-methyl 5 p-methylbenzoylpyrrole-2acetamide acetate (ST-679, previously called MED-15) in the form of tablets and envelopes in order to establish the bioequivalence of the above-mentioned preparations. The results obtained indicate that the administration of 600 mg of 2 methoxyphenyl 1-methyl 5 p-methylbenzoylpyrrole-2acetamide acetate (ST-679) tablets produces from a pharmacokinetics point of view, in man, pharmacokinetic parameters comparable to those obtained following administration of the same dose of the drug in envelopes. It is, therefore, possible to affirm that the preparation of 2-methoxyphenyl 1-methyl 5-p-methylbenzoylpyrrole-2acetamide acetate (ST-679) in envelopes is bioequivalent to that of the tablets.


The area's natural analogues, vitrifi ed forts, combustion technology, and vitrifi ed waste have been reviewed.The purpose was to identify if investigations of vitrifi ed rock in hill forts might b ...


Education: M.Sc. in Computer Science at the University of British Columbia (2007) • Thesis Title: A Parallel Workflow for Online Correlation and Clique-finding – With Applications to Finance B.Sc. (Honours) with High Honours in Computer Science, University of Regina (2003) • Presidents Medal, for Academic Excellence and Leadership • University Prize in Science, for the Most Outstanding Science Graduate One semester abroad on an Exchange Program at the University of Technology, Sydney (2002) Graduated from Sheldon Williams Collegiate with Honours (1998)


The description of 3D shapes using features that possess descriptive power and are invariant under similarity transformations is one of the most challenging issues in content-based 3D model retrieval. Spherical harmonics-based descriptors have been proposed for obtaining rotation invariant representations. However, spherical harmonic analysis is based on a latitude-longitude parameterization of the sphere which has singularities at each pole, and therefore, variations of the north pole affect significantly the shape function. In this paper we discuss these issues and propose the usage of spherical wavelet transforms as a tool for the analysis of 3D shapes represented by functions on the unit sphere. We introduce three new descriptors extracted from the wavelet coefficients, namely: (1) a subset of the spherical wavelet coefficients, (2) the L1 and, (3) the L2 energies of the spherical wavelet sub-bands. The advantage of this tool is threefold; First, it takes into account feature localization and local orientations. Second, the energies of the wavelet transform are rotation invariant. Third, shape features are uniformly represented which makes the descriptors more efficient. Spherical wavelet descriptors are natural extensions of spherical harmonics and 3D Zernike moments. We evaluate, on the Princeton Shape Benchmark, the proposed descriptors regarding computational aspects and shape retrieval performance.


When defining placenta previa is when it is located very close to the cervix according to its proximity to the internal cervical os is classified in total, partial, marginal and low insertion. It is also one of the main obstetric complications that occur in the second half of pregnancy which affects maternal fetal wellbeing and may even cause death, is the main cause of hysterectomy. The clinical picture for diagnosis is transvaginal bleeding of red appearance without pain, among the risk factors is previous cesarean, multiparity, history of abortion, etc, the cases worldwide is 1 per 200 pregnancies The main objective of the present investigation is to apply the process of nursing care in pregnant women with placenta previa and their fetal maternal complications. Through the process of nursing care, priority care is identified through the NANDA taxonomy, NIC interventions and NOC results, since it is a scientific, systematic method for professional practice and therefore helps to make correct decisions to restore the patient's health. purpose is to give quality attention to the user. Through the bibliographic search, information was collected in more than 10 scientific journals of high impact, clinical practice guidelines and statistical references from the Ministry of Public Health of Ecuador, which correspond to publications of the last five years according to the theme of study.


Rat hepatoma cells were irradiated with 1000 rads of gamma radiation in vivo 7 days after intraperitoneal inoculation. Cells were removed immediately after exposure and incubated in medium containing radioactive amino acids or radioactive thymidine. Incorporation of these precursors was monitored for the first half hour, during which DNA and nuclear proteins were normally synthesized at a constant rate. The incorporation of radioactive thymidine into DNA after 1000 rads was about half that found in unirradiated cells, and the incorporation of amino acids into histones and urea-soluble nuclear proteins was unaffected during the first half hour. The presumed normal relationship between DNA synthesis and nuclear protein synthesis appears not to be maintained in irradiated ascites tumor cells.


ABSTRACT The aim of our study is to analyze how the government can ensure economic security in a socially oriented economy and to develop measures for improving the economic effectiveness of the Central Federal District (CFD). Most of the social indicators we analyzed fail to reach their threshold value, which corresponds to low (pre-crisis) and crisis levels. We provide a model for comparing actual and threshold values based on the statistical normalization of various social indicators. Based on the results of our study, we assess the economic security of the Central Federal District as low (i.e., pre-crisis) and propose a number of measures to improve the effectiveness of the government to ensure economic security.


The recovery of water from tailings is most efficiently achieved in the processing plant, but this must be balanced against the efficient management of tailings disposal. The densification and strengthening of tailings is best achieved by depositing the tailings in thin layers and allowing time for consolidation and desiccation. This can be assisted by amphirolling to drain surface water down the tailings beach and increase the surface area exposed to desiccation, and by subsequent dozing to compact the tailings. The paper describes the application of soil mechanics principles to tailings dewatering to recover process water, densification to minimise the volume required to store the tailings, and strengthening to facilitate upstream raising and eventual capping for rehabilitation purposes. The paper is written in the context of semiarid climates such as exist at many mining operations in Australia.