Mini-MALTA is a Monolithic Active Pixel Sensor prototype developed in the TowerJazz 180 nm CMOS imaging process, with a small collection electrode design (3μm$^2$ ), and a small pixel size (36.4 μm), on high resistivity substrates and large voltage bias. It targets the outermost layer of the ATLAS ITK Pixel detector for the HL-LHC. This design addresses the pixel inefficiencies observed in previous MALTA and TJ-Monopix prototypes. The implementation of a mask change in the fabrication or an additional implant allows to improve the charge collection performance at the edges of the pixel thus improving the radiation hardness properties. This contribution will present the results from characterisation in particle beam tests that show full efficiency up to 1 · 10$^{15}$ $n_{eq}$ /cm$^2$ .


: According to the two-dimensional spatial relationship model of the relative motion between the missile and the target, on the basis of conventional proportional guidance and extended proportional guidance, a composite guidance method using conventional proportional guidance and extended proportional guidance to switch each other for three-dimensional guidance is proposed. The switching basis is based on the angle between the missile speed direction and the azimuth angle. When the included angle is large, the extended proportional guidance is used, and when the included angle is small, the conventional proportional guidance is used. Thus, the problem of rapid increase of miss distance at the end of conventional proportional navigation can be avoided


The survival difference between de‐novo sinonasal squamous cell carcinoma (DN‐SNSCC) and SCC arising from inverted papillomas (IPs) is unclear. The purpose of this study was to compare the outcomes between DN‐SNSCC and IP‐transformed SNSCC (IP‐SNSCC) patients.


Aim: To investigate the association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi. Methods: Cross sectional study of 65 patients with posterior uveal melanoma and 218 controls. Iris colour, iris freckles, iris naevi, and choroidal naevi were recorded for each eye of each patient. Results: Iris freckles were present in 40 (61.5%) patients with melanoma and 135 (61.9%) controls (p = 0.494). Iris naevi were present in four (6.2%) patients with melanoma and nine (4.1%) controls (p = 0.955). Choroidal naevi were present in 12 (18.5%) patients with melanoma and 38 (17.4%) controls (p = 0.815). Conclusion: This study did not detect an association between posterior uveal melanoma and iris freckles, iris naevi, or choroidal naevi.


Remote conferencing systems are increasingly used to supplement or even replace in-person teaching. However, prevailing conferencing systems restrict the teacher's representation to a webcam live-stream, hamper the teacher's use of body-language, and result in students' decreased sense of co-presence and participation. While Virtual Reality (VR) systems may increase student engagement, the teacher may not have the time or expertise to conduct the lecture in VR. To address this issue and bridge the requirements between students and teachers, we have developed Tutor In-sight, a Mixed Reality (MR) avatar augmented into the student's workspace based on four design requirements derived from the existing literature, namely: integrated virtual with physical space, improved teacher's co-presence through avatar, direct attention with auto-generated body language, and usable workflow for teachers. Two user studies were conducted from the perspectives of students and teachers to determine the advantages of Tutor In-sight in comparison to two existing conferencing systems, Zoom (video-based) and Mozilla Hubs (VR-based). The participants of both studies favoured Tutor In-sight. Among others, this main finding indicates that Tutor In-sight satisfied the needs of both teachers and students. In addition, the participants' feedback was used to empirically determine the four main teacher requirements and the four main student requirements in order to improve the future design of MR educational tools.


The Na translocating NADH:quinone oxidoreductase (Na-NQR) is a unique respiratory enzyme catalyzing the electron transfer from NADH to quinone coupled with the translocation of sodium ions across the membrane. Typically, Vibrio spp., including Vibrio cholerae, have this enzyme but lack the proton-pumping NADH:ubiquinone oxidoreductase (Complex I). Thus, Na-NQR should significantly contribute to multiple aspects of V. cholerae physiology; however, no detailed characterization of this aspect has been reported so far. In this study, we broadly investigated the effects of loss of Na-NQR on V. cholerae physiology by using Phenotype Microarray (Biolog), transcriptome and metabolomics analyses. We found that the V. cholerae DnqrA-F mutant showed multiple defects in metabolism detected by Phenotype Microarray. Transcriptome analysis revealed that the V. cholerae DnqrA-F mutant up-regulates 31 genes and down-regulates 55 genes in both early and mid-growth phases. The most up-regulated genes included the cadA and cadB genes, encoding a lysine decarboxylase and a lysine/cadaverine antiporter, respectively. Increased CadAB activity was further suggested by the metabolomics analysis. The down-regulated genes include sialic acid catabolism genes. Metabolomic analysis also suggested increased reductive pathway of TCA cycle and decreased purine metabolism in the V. cholerae DnqrA-F mutant. Lack of Na-NQR did not affect any of the Na pumping-related phenotypes of V. cholerae suggesting that other secondary Na pump(s) can compensate for Na pumping activity of Na-NQR. Overall, our study provides important insights into the contribution of Na-NQR to V. cholerae physiology. Citation: Minato Y, Fassio SR, Kirkwood JS, Halang P, Quinn MJ, et al. (2014) Roles of the Sodium-Translocating NADH:Quinone Oxidoreductase (Na-NQR) on Vibrio cholerae Metabolism, Motility and Osmotic Stress Resistance. PLoS ONE 9(5): e97083. doi:10.1371/journal.pone.0097083 Editor: Joel H. Weiner, University of Alberta, Canada Received December 11, 2013; Accepted April 14, 2014; Published May 8, 2014 Copyright: 2014 Minato et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This research was supported by grants from the National Institutes of Health to C.C.H. [AI-063121-02] and to J.F.S [S10RR027878 and P30ES000210] and the Deutsche Forschungsgemeinschaft (FR1321/3-1) to J.S. S.R.F was partially supported by the OSU Undergraduate Research, Innovation, Scholarship & Creativity (URISC) fund and the OSU Howard Hughes Medical Institute Summer Undergraduate Research Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: email@example.com ¤ Current address: Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, United States of America . These authors contributed equally to this work. Introduction Na-translocating NADH:quinone oxidoreductases (Na-NQR) are found in the respiratory chains of a number of marine and pathogenic bacteria (reviewed in [1,2]). In organisms that express Na-NQR, this enzyme is the gateway for electrons into the respiratory chain. Na-NQR accepts reducing equivalents from NADH and donates them to the quinone pool [3,4]. The energy from this redox reaction is used to pump sodium ions from the inner to the outer side of the membrane, thereby building a sodium motive force (SMF). Besides Na-NQR, two more types of respiratory NADHdehydrogenases have been reported, the proton-pumping NADH dehydrogenases (NDH-1 or Complex I) and NDH-2 [5]. Similar to Na-NQR, NDH-1 utilizes energy from the redox reaction, but it pumps protons from the inner to the outer side of the membrane to build a proton motive force (PMF). Unlike Na-NQR and NDH-1, NDH-2 has neither H nor Na efflux activities. A few pathogenic bacteria, such as Yersinia pestis and Pseudomonas aeruginosa, have all three types of NADH dehydrogenases, but most bacteria possess one or two of these NADH dehydrogenases [5,6]. Lack of the major NADH dehydrogenase activity usually significantly affect bacterial physiology. Escherichia coli has a single NDH-1 (encoded by nuoA-N) and NDH-2 (encoded by ndh), and it is known that NDH-2 is the major enzyme for aerobic growth, whereas the NDH-1 is essential for anaerobic fumarate and DMSO respiration [7]. Moreover, it is known that the E. coli strain lacking NDH-1 showed growth retardation and increased acetate secretion after the transition to stationary growth phase when grown in mixed amino acids media [8]. It was also shown that the PLOS ONE | www.plosone.org 1 May 2014 | Volume 9 | Issue 5 | e97083 E. coli strain lacking NDH-1 grew poorly when grown in minimal media supplemented with acetate as the sole carbon source [8]. Vibrio cholerae is the causative agent of cholera, a waterborne severe diarrheal disease. Genome sequencing revealed that V. cholerae does not have NDH-1 but has Na-NQR (encoded by nqrA-F) and NDH-2 (encoded by ndh) [2,6]. Although Na-NQR is not essential for V. cholerae growth [9], the DnqrA-F mutant strain of V. cholerae shows a marked growth defect when grown in LB [10], similar to the E. coli strain that lacks a functional NDH-1 [8]. In addition, the V. cholerae Dnqr A-F mutant strain shows multiple defects in carbon metabolism [10]. Furthermore, Na-NQR also affects V. cholerae virulence gene expression possibly by affecting acetyl-CoA metabolism via the TCA cycle [9,10] and survival in vivo [11]. In this study, we aimed to investigate the effects of a DnqrA-F mutation on broad aspects of V. cholerae physiology by using Phenotype Microarray (Biolog), transcriptome, and metabolomics analyses. We found that DnqrA-F mutant strain showed multiple defects in metabolism but did not show any defect in Na pumping-related phenotypes of V. cholerae. Materials and Methods Bacterial strains and growth conditions V. cholerae O395N1, V. cholerae O395N1 DnqrA-F [12] and V. cholerae O395N1 DpomAB [13] strains were used in this study. Bacterial strains were kept at 280uC in 20% glycerol stocks. Bacterial strains were grown in Luria-Bertani (LB) medium at 30uC or 37uC. Streptomycin was supplemented at 100 mg/ml. When necessary, 33 mM L-lactate was used. Phenotype microarray (PM) analyses Phenotype microarrays were performed using PM3 to PM10 MicroPlate (Biolog) at Biolog's PM Services group. All plates used pyruvate as sole carbon sources. DNA microarray analyses Cells of V. cholerae O395N1 and V. cholerae O395N1 DnqrA-F strains, grown in LB (pH 6.5) at 30uC for 4 hours and 8 hours, were treated with RNA Protect Bacteria Reagent (Qiagen). RNA was extracted using the QIAGEN RNeasy Mini Kit (Qiagen). RNA was concentrated using the QIAGEN RNA MiniElute Cleanup kit (Qiagen) and sent to the Center for Genome Research and Biocomputing at Oregon State University, Corvallis, OR, following protocols outlined in the NimbleGen array user's guide, version 5 for cDNA synthesis and microarray analysis using NimbleGen Microarray plates and reagents. The microarray data are accessible at the Gene Expression Omnibus (accession number, GSE56387). Metabolite extraction V. cholerae O395N1 and V. cholerae O395N1 DnqrA-F strains were grown in LB (pH 6.5) at 30uC for 2 hours and the supernatant was removed by centrifugation (8000 rpm, 4 uC, 5 min). The pellet was resuspended in 600 mL of LC-MS-grade water in 1 mM HEPES and 1 mM EDTA (pH 7.2). Metabolites were extracted from bacterial cells by using the boiling water method as previously described [14]. LC-MS/MS Mass spectrometry based metabolomic profiling was performed as previously described [15]. Briefly, liquid chromatography (LC) was performed on a Shimadzu Nexera system and metabolites separated on an Inertsil phenyl-3 stationary phase (GL Sciences, 5 uM, 4.6 6150 mm). Mass spectrometry was performed on an AB SCIEX Triple TOF 5600 quadrupole-time-of-flight mass spectrometer. MS/MS spectra were gathered on the fly by information dependent acquisition. Most metabolites were identified by mass, isotope distribution, MS/MS fragmentation, and when standards were available, retention time. In the absence of chemical standards, MS/MS spectra were compared to those in the METLIN online database. To account for analytical and sample preparation variation, samples were normalized to total ion count. Central energy metabolites (metabolites of the tricarboxylic acid cycle, pentose phosphate pathway, and glycolysis and amino acids) were targeted post-data acquisition and in addition, untargeted statistical analysis (Student's t-test p-value plotted against fold-change) revealed large (.10-fold) changes in cyclic AMP and cyclic GMP, and subsequently, related metabolites (purines and pyrimidines) were targeted post-data acquisition. Growth measurement Growth measurement assays were performed as previously described [16]. Briefly, overnight grown bacterial cells were inoculated into 200 ml liquid medium in 96-deep-well plates (Whatman) at an initial OD600 of 0.05 and grown at 37 uC for 18 h with vigorous aeration. LBB medium (non-cationic L broth) was supplemented with streptomycin and varying concentrations of ethylene glycol. The initial pH of the media was adjusted with HCl to 6.5 and buffered by the addition of 60 mM BTP. Growth was then measured as OD600 by scanning the plates on a Bio-Rad iMark microplate absorbance reader. All experiments were repeated at least three times in triplicate. Measurement of acetate excretion Acetate excretions from bacterial cells were measured as previously described [10]. Motility assay Motility of V. cholerae strains was determined on soft agar plates buffered with 100 mM Bis/Tris (pH 6.5) contain


Abstract : An approximate numerical method for calculation of trajectories of hypersonic vehicles is described, with particular reference to gun-launched vehicles. Because of the form of the hypersonic drag coefficient, a relatively simple calculation using functions which depend only on altitude is possible. Reasonable accuracy can be obtained even for computations in which very large calculation intervals are used. The method is particularly suitable for preliminary engineering calculations which do not justify a detailed computer solution, and has the added advantage of giving the analytic forms linking input and output. The technique is shown to be applicable to glide trajectories with and without drag and to rocket powered trajectories as well.


Correlating surface features and the resultant evolution of optical properties is important in the study and application of two-dimensional (2D) materials like transition-metal dichalcogenides. The authors measure photoinduced forces in atomically thin layers of MoS${}_{2}$ and WS${}_{2}$ using a modified atomic force microscope, enabling their visualization with high contrast. A spectral-force retrieval technique enables evaluation of the distinct excitonic peaks of the two structures, which resemble the excitonic features of far-field absorption. Spectral signatures of defects and edges are also observed, opening the way toward nondestructive, high-resolution defect imaging of 2D materials.


MgHPO4 has been introduced as a reactant that interacts with LiNi0.6Co0.2Mn0.2O2 (NCM622) to achieve the dual modification of Mg2+ gradient doping and Li3PO4 surface coating. The structure, morphology, elemental distribution,...


Planktonic organisms are important components of aquatic ecosystems and there is a growing interest in their exploitation for industrial purposes, such as in biofuel production using microalgae as a biomass source. The evaluation of plankton composition and abundance usually relies on time‐consuming microscopic analysis. However, automatic imaging systems are becoming increasingly available to perform such tasks. Here we present a novel method based on the visual rhythm (VR) approach to detect particles in fluidic systems through imaging techniques. It was tested on large datasets of plankton images and its performance was compared to a traditional frame‐by‐frame (FBF) approach. Performed tests demonstrated that the VR‐based approach is faster and much more precise for plankton detection and segmentation (accuracy above 96% and precision above 95%), while having the same accuracy as the FBF method. Although designed for continuous monitoring of plankton samples, the method can be easily adapted to different applications in which targets to be detected and identified move in a unidirectional flow.


We develop and analyze a mathematical model for the transmission dynamics of HIV that accounts for behavioral change. The contact rate is modeled by a decreasing function (response function) of HIV prevalence to reflect a reduction in risky behavior that results from the awareness of individuals to a higher HIV prevalence. The model also includes a distributed delay representing the time needed for individuals to reduce their risky behavior. We study mathematically and numerically the impact of the response function and the distributed delay on the model's dynamics. Threshold values for the delay at which the system destabilizes and periodic solutions can arise through Hopf bifurcation are determined.


The characteristics of occupant behaviour models presented in scientific literature do not necessarily convey the properties of a model related to its outcome on – e.g. the mean behavioural state, the variance in behavioural actions, or the resulting energy use for a given building. Given the huge variety of modelling approaches and observed behavioural patterns, the question arises, whether the existing characteristics are meaningful for those who should apply these models in daily praxis, i.e. building simulation engineers or architects, less trained in statistical measures. Therefore, this paper presents a method to create characteristics for occupant behaviour models, so that the model's behaviour is more tangible for those who should apply occupant behaviour models. Through standardized simulations including occupant behaviour models, the average length of usage, the number of interactions, and typical schedules for summer and winter are extracted, which allow a straightforward comparison of a model's behaviour.


The management of a 1200 g preterm infant with a large mobile septic right atrial thrombus attached to the tip of a central venous catheter is presented. The thrombus was successfully removed from the right atrium under direct vision utilizing vena caval inflow occlusion technique.


Para ice hockey is a Paralympic discipline in which athletes with a physical impairment at the lower part of the body play sitting on a sledge. To take part in the competitions, athletes have to meet the minimum disability criteria. In recent years, the International Paralympic Committee has promoted the necessity to move towards evidence-based assessment of the impact of the impairment on performances. In Para ice hockey, performance is related to the ability of making sprint and to the maneuverability in curves and in handling the puck. A new agility test to measure athletes' performance in terms of taking curves is here proposed and assess for its intraday reliability. Two acquisitions were done in order to collect respectively left and right curves. Six athletes performed three repetitions for each acquisition (left and right), for a total of six trials. The time required to complete the test (execution time) was collected for each trial. In addition, blade angle and trunk angle were calculated. Blade angle is the inclination of the blade with respect to the horizontal; whereas trunk angle is the inclination of the trunk with respect to the horizontal. The intraclass correlation coefficient, the absolute and percent standard error of measurement, and the mean difference were calculated between the three repetitions for both left and right side, for all variables. For kinematic and temporal variables, results showed high value of intraclass correlation coefficient (>0.82), low value of standard error of measurement (<4.7%), and low value of mean difference (<1.75° and 0.18s) for both left and right curves. A difference (p<0.01) was found between left and right curves for the kinematic variables; whereas execution time did not show any difference between sides. Finally, the first curve was different (p<0.01) compared to the others in both blade angle and trunk angle for left and right curves. In conclusion, because of the low within-subject variation, this agility test may be considered sport-specific measures of performance for evidence-based classification. In addition, it can be used by coaches to make personalized training.


The presence of gastrointestinal nematodes (GIN) in sheep is a low productivity cause. This study aimed to determine the in vitro efficiency of Gliricidia sepium, Leucaena leucocephala, Guazuma ulmifolia, and Bursera simaruba aqueous extracts at three different doses (0.75, 1.00, and 1.25 mL), inhibiting the egg hatching of GIN from sheep. The inhibition efficiency in egg hatching (IEH), larval identification, and its genera proportion were evaluated. Analysis of data was performed using Chi-square tests and analysis of variance. The four extracts obtained an IEH of 50%, being similar (p > 0.05) between them. The 1.25 mL dose and its combinations of Leucaena leucocephala and Gliricidia sepium at 1.25 mL dose obtained the highest efficiency (68.0, 85.0, and 77.0%, respectively). Five genera of larva were identified (Haemonchus spp, Trichostrongylus spp, Oesophagostomum spp, Cooperia spp, and Nematodirus spp). The highest prevalence (p ≤ 0.05) was obtained by Haemonchus spp (58.0%). According to the results, the four aqueous extracts exhibited ovicidal activity (GIN). However, the 1.25 mL dose and the Leucaena leucocephala, Gliricidia sepium extracts at 1.25 mL doses were the most effective.


The process by which a linear sequence of amino acids folds into a discrete and functional three-dimensional protein is one on which life depends. Although the code that governs folding remains a mystery, we do know that the primary sequence is subject to evolutionary pressure to adjust folding rate and product stability according to physiological needs. The failure of a protein to fold correctly leads to a functional deficit, which can have serious consequences, as in cystic fibrosis. However, there is an emerging class of late-onset, slow-progressing diseases that appear to result instead from a gain of function associated with the abnormally folded form of the protein. These diseases, which are characterized by ordered, fibrillar aggregates comprising different proteins, include common neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) as well as many rare systemic diseases such as familial amyloid polyneuropathy (1, 2).


Generally,the notch depth of easy-open-end is adjusted through stopping the machine working and changing the gasket which under the easy-open die.Aiming at this situation,a new scheme is brought forward.The new scheme suggests to use the induction heating to heat easy-open-end die.The height of easy-open-end die is changed according to the principle of expansion caused by heat and contraction caused by cold.The notch depth of easy-open-end is adjusted.The temperature data of induction heating is analyzed by Matlab software.The result shows that the uniformity and linearity of heating method of heating die is good when heating the easy-open-end die is heated by induction.The changing height of easy-open-end die is measured by TESA inductive probe which further verify the feasibility of the scheme using the induction heating to ajust the notch depth of easy-open-end.


1. Electron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, Jupiter, FL. 2. Molecular Mechanisms of Synaptic Function, Max Planck Florida Institute for Neuroscience, Jupiter, FL. 3. Department of Anatomy and Cell Biology Iowa Neuroscience Institute, and Aging Mind Brain Initiative, University of Iowa, Iowa City, Iowa. 4. Department of Otolaryngology, Iowa Neuroscience Institute, and Aging Mind Brain Initiative, University of Iowa, Iowa City, Iowa.


According to project experience,the paper introduces the characteristics and the differences of ICE contract with the mainland standards,analyzes the management differences from the perspectives of pre-contract risk and project management in construction process,and summarizes it's problems.


Absorption of nonheme iron has been studied extensively by the use of extrinsic tag radio-labeled iron to meals. Nevertheless, this method is unsuitable for screening large number of meals. The purpose of this study is to determine and compare iron availability from various kinds of meals in laboratory conditions that mimic the human stomach. Three hundred and seventy two common meals from the Siriraj Hospital kitchen were tested. The results of iron availability tests on the 372 Siriraj meals were classified as having low (5.77 ± 2.42%), intermediate (12.42 ± 1.55%), high (17.7 ± 1.44%) and very high (25.8 ± 3.65%) iron availability. Only meals of high and very high iron availability (22.1 ± 4.99%) provided sufficient amounts of iron for the special requirement of teenagers and woman of childbearing age (2.22 to 3.24 mg of Fe per day) while meals of low and intermediate iron availability (8.12 ± 3.84%) provided only 1.02 mg of iron per day. An average amount of estimated iron availability from the 372 meals was 14.12 ± 8.2% of 1.77 mg per day. This was slightly inadequate because 2.06 to 2.15 mg were required per day for the high-risk groups. Results of this study indicated that 42.7% of Siriraj meals adequately provided the physiologic requirement of the high-risk segments of the population, but 57.3% of the meals did not. Improvement of food choices to increase dietary iron intake can be accomplished by including meat, fish or poultry and a source of vitamin C in every meal.


The worldwide epidemic of childhood obesity is progressing at an alarming rate. Obesity in childhood at high risk of becoming obese in adulthood and potentially experience metabolic disease and degenerative disease in the future. Obesity is not just an individual problem. It is a population problem and should be tackled as such. Various factors causing obesity in children include children's diet, level of physical activity, family factors, child psychological and genetic factors. This paper attempts to explore the problem more closely by conducting a qualitative study, the main objective of which is to determine barriers to a healthy lifestyle and variables that underlie overweight/obesity in children from their parents perspective. This research is a qualitative research with the phenomenological method. A total of 3 focus group discussions and 7 in-depth interviews were conducted, between July and October 2016, to explore parent's, teacher's, and nutritionist perceptions about underlying factors of their overweight/obesity and barriers to a healthy behavior.


The resonant transfer and excitation cross sections in collisions of U{sup 89+} ion with light targets have been calculated in impulse approximation using the multiconfiguration Dirac-Fock method. Effects of relativity not only shift the peak positions significantly but also change the number of peaks. Relativistic effects have been found to increase the total dielectronic recombination strength by 50%. Including Breit interaction in calculations of Auger matrix elements can enhance the resonant transfer and excitation cross sections by as much as a factor of 2.


The collaborative model for learning implies students forming teams in order to reach a common goal. The objectives of this research are both exploring the impact of the collaborative model over the performance of those learners who study contents related to the formation of spokespersons for organizations; and evaluating the potential of frame analysis as a content for training in public relations. To delve into those issues, a case study exercise was administered to six groups of students of the "Training for Spokespersons" subject, consisting of analyzing the audiovisual intervention of a spokesperson talking on behalf of a strike commitee, and answering questions about target publics and frames of reference. The exercise succeeded in helping the students understand the role of emotional communication; however, they still got slightly confused about frame analysis and its link with the concept of social norm. For future research, it becomes necessary to focus on moving even more away from the classic master classes, as well as using cases that students can feel closer to their interests. With respect to frame analysis, the results encourage the teaching of more precise classifications in terms of general frames about a certain topic, and specific frames about particular situations.


Origin detection method of characteristic differences in honey was established.Honey from different places was digested with acid.The content of potassium,calcium,sodium,magnesium,copper,zinc,iron,manganese and phosphonium in honey were determined by spectrophotometry.Compared with the content of elements in honey from different places,the results showed that there was significant difference in content of some elements in honey that come from different regions.The relative standard deviation was 0.7%~3.9%,the recovery was 94.30%~111.26%.


Study atmosphere construction is an extremely important aspect of higher education reform and personnel training.It can help to promote the healthy development of universities and colleges and it can also help to improve the comprehensive quality of students.As the backbone force of higher education students' affairs,political instructors should take the Scientific Outlook on Development as the guidance and highlight the "people-oriented" work ide-ology and plays an important role in the comprehensive,coordinated and sustainable development of the students.


Segmentation is one of the most complex and time reliant steps in the Iris recognition process. Using the powerful and fast k-means algorithm alongside Neural Networks, this algorithm manages to isolate the Iris within the image of the eye, not only with high precision, but also with a great reduction in time and computational load our scheme is capable of deciding whether the extraction of characteristics after segmentation can be carried out. Thus, enhancing the IRIS recognition and can be extended to include other Biometrics


Visual perception in virtual reality devices is a widely researched topic. Many newer experiments compare their results to those of older studies that may have used equipment which is now outdated, which can cause perceptual differences. These differences in hardware can be simulated to a degree in software, provided the capabilities of the current hardware meet or exceed those of the older hardware. I present the HMD Simulation Framework, a software package for the Unity3D engine that allows for quick modification of many commonly researched HMD characteristics through the Inspector GUI built into Unity. I also describe a human subjects experiment aimed at identifying perceptual equivalence classes between different sets of headset characteristics. Unfortunately, due to the COVID-19 pandemic, all human subjects research was suspended for safety reasons, and I was unable to collect any data.


We have studied the X-ray and gamma shielding parameters like mass attenuation coefficient, mean free path, half value layer, tenth value layer, effective atomic numbers, electron density, exposure buildup factors, and specific gamma ray constant in commonly used polymers such as polysterene, polypropylene, polytetrafluroethylene (PTFE), polyvinylchloride (PVC), polychlorotetrafluroethylene (PCTFE). We have also measured X-ray and gamma shielding parameters at different energies such as 170Tm (0.084 MeV), 137Cs (0.662 MeV) and 60Co (1.170, 1.330 MeV) in the same polymers. The measured values agree well with the theoretical values. Neutron shielding parameters such as coherent neutron scattering length, incoherent neutron scattering length, coherent neutron scattering cross section, incoherent neutron scattering cross section, total neutron scattering cross section and neutron absorption cross section are in the same polymers. PCTFE is found to be good shielding material for the gamma/X-ray and neutron radiation.


(-)-3-Dehydroshikimic acid (3-DHS, 4), a C(7)-building block now available in large quantity from corn syrup, has been converted into the sialic acid (-)-KDN (3) as well as its C-7- and C-8-epimers. (-)-Quinic acid can be used for the same purpose. [structure: see text]


Knee injuries are among the most common human afflictions despite age, gender, or lifestyle. They are often detected using a non-invasive diagnostic tool such as Magnetic Resonance Imaging (MRI) of the knee. With the rising number of injuries yearly, the risk of diagnostic errors by radiologists increase exponentially. In order to mitigate this, deep learning methods have been used for designing an automatic MRI interpreter. MRNet public dataset is an established knee injury dataset consisting of multi-view MRI images with multi-label classification. The prior deep learning solutions utilizing this dataset including the MRNet model, ignore the relationship and dependency among the different injuries and views. Given the specific properties of this dataset and problem, we propose a tailored multi-label classification network with enhanced data and feature fusion. The designed model out-performs the MRNet baseline model in terms of complexity and performance reaching an Area Under the Receiver Operating Characteristic Curve (AUC) of 0.925.


ABSTRACT Links between special and ordinary schools may involve the sharing of staff, pupils or resources. In this paper data from a questionnaire survey of a quarter of the special schools in England and Wales are presented which show the extent of such links. The different forms that links take are described and the reasons for their formation are outlined. The finding that 85 per cent of special schools had links with ordinary schools, or had plans to develop them or had past experience of them, suggests that such arrangements are of significance in special schools in England and Wales. Links open up contact between different establishments and may focus attention on the function of special schools. They are an important element in any discussion of the future of special schools and deserve careful scrutiny.


Abstract : An extensive data base on a 2:1 elliptical nosetip shape to be utilized for verification of the AVCO MTSCT three-dimensional transition code was generated in the NSWC Hypersonic Tunnel at Mach Number 5. Four nosetip models in which the surface roughness was varied from a smooth wall to a roughness value of 10 mils were tested. The first three nosetips were instrumented with 112 backfaced chromel-alumel thermocouples. The fourth model (i.e., 10-mil roughness) instrumentation consisted of 67 thermocouples and 31 Statham pressure transducers. The test matrix consisted of sixty runs where the variables included angle-of-attack, tunnel Reynolds number, and wall enthalpy ratio. (Author)


Submitted for the MAR09 Meeting of The American Physical Society Systematic tunability of self-assembled block copolymer patterns YEON SIK JUNG, CAROLINE ROSS, Massachusetts Institute of Technology — The morphology and length scale of diblock copolymers (BCPs) are determined by the chain lengths, and therefore to obtain different geometries and feature sizes, polymers with different chain lengths or BCP/homopolymer blends have been employed. Here, we report on the solvent vapor induced tunability of pattern dimension and morphology of thin films of polystyrene-polydimethylsiloxane (PS-b-PDMS) BCPs, which provide robust patterns with exceptionally good ordering due to their large interaction parameter.[1] Vapor pressure can control the interfacial interaction between the two blocks, and a mixed solvent can manipulate the effective volume fraction of each block. We show both coupled and independent control of the microdomain size and the periodicity by changing the vapor pressure and the mixing ratio of a selective (heptane) and a partially selective (toluene) solvent. We also demonstrate the transformations from spheres to cylinders and from cylinders to perforated lamellar structures by increasing the portion of selective solvent in the vapor. These results are supported by a theoretical model. 1Y. S. Jung et al., Nano Letters 7, pp. 2046-2050 (2007); Science 321, pp. 939 943 (2008); Nano Letters 8, pp. 2975-2981 (2008) Yeon Sik Jung Massachusetts Institute of Technology Date submitted: 24 Nov 2008 Electronic form version 1.4


ABSTRACT The restoration planning process has yielded a number of possible alternatives for restoring resources and services injured by the Exxon Valdez oil spill. They were developed by resource m...


The method of analysis for a polycondensation polymer containing the carboxylate and sulfonate functional groups has been devised. A combination of infrared spectroscopy and combustion analysis provides a simple and accurate determination of the monomeric units and their molar distribution in the polymer.


In the article,the network security technology applications in the construction of new countryside in Jiangxi were described in detail.By in-depth analysis,the current internet was still at security risk.Finally,taking the use of practical experience,the improvement measures for the development of new countryside construction networks with high safety and efficiency in Jiangxi were proposed.


Plankton diversity studies were carried out in the coastal waters of Paradip, Bay of Bengal from January 2015 to October 2015. There was broad variation in plankton diversity and water quality indices. Higher number of plankton taxa was reported in the month of October when SST, DO and nutrient (NO 3 and SiO 3 ) concentration was also higher. In the month of October the SST value was 30.80°C and dissolved oxygen varied from 3.28mg/l to 5.21mg/l. Nitrate and silicate both show maximum in October month i.e., 76.89µM/l and 36.67µg/l respectively. Salinity was maximum in the month of March (37.21ppt) and minimum in the month of October (23.95ppt). Phosphate was maximum in January month (0.113mg/l) and minimum in March (0.08mg/l). Nutrients (nitrate and silicate), SST, DO and Salinity act as limiting factor in the distribution pattern of planktons.


In modern conditions, jurisprudence is very often confused with bureaucracy. This circumstance is due to the fact that everyone is accustomed to accurately and rigorously comply with each letter of the law and another, even not the most significant legal act in terms of legal force. At the same time, one has to face the fear of fulfilling this or that provision incorrectly, which leaves an imprint not only on the well-being of citizens, but also creates a certain negative tension when contacting public authorities, state or municipal institutions, etc. As a result, the law has turned from a means of resolving conflict situations and stabilizing relations in society into something that interferes with the life of an ordinary person. It seems that this happened because the "law for man" paradigm turned into "man for the law". Such reflections prompted the author to try to formulate a theory of the correlation of subjects of law, which would determine the key positions of competent persons and bodies, not only within the framework of legal relations. Nevertheless, the latter continue to play the most significant value and will be considered in this work in more detail. The main conclusion is that the law should serve people, and not vice versa, for which, when creating it, it is necessary to take into account their real interests, what happens in life instead of modeling their behavior in the future, also using measures of state coercion.


Sensorless speed control of Induction Motor drive has, become an advanced technology for control of speed over a wide speed range with improved stability. The elimination of the rotor speed sensor, without detoriation in the performance, is a recent trend in control of high performance drives. The drawbacks of conventional Model Reference Adaptive Control are parameter sensitivity, low speed instabilities and the stator resistance is the single most critical parameter for the fore mentioned disadvantages. Model Reference Adaptive Strategy (MRAS) based on rotor flux with observer has been proposed which overcomes the above said drawbacks. By this method a robust scheme is designed with reduced calculation effort and accurate speed estimation even at low speeds, because the sensorless flux observer is insensitive to motor parameter deviation. A closed loop estimation system with robustness against motor parameter variation is used for the control approach and the deviation between the estimated speed and the actual speed has been reduced. The proposed MRAS based speed estimator has been simulated for various load conditions using MATLAB/Simulink. The results prove that the proposed MRAS can be applied for retrofit applications.


The aim was to characterize the changes of plasma component concentrations after feeding in Japanese Black (B) and Japanese Shorthorn (S) cattle. Eight females, five B and three S, with a mean bodyweight (standard deviation) of 282.0 (20.3) kg  were  selected  and  supplied  with  only  water  for  28 h  after  feeding.  Blood  was  taken  from  the  jugular  vein  at 4-h intervals for 32 h after feeding. Metabolite (cholesterol, CL; glucose, GLU; nonesterified fatty acid, NEFA; triacylglycerol, TG; total protein, TP) and insulin-like growth factor-1 (IGF-1) concentrations in plasma were measured. In both breeds GLU tended to decrease linearly with a similar slope. Differences between the initial mean NEFA at 4 h after feeding (Start) and that at 24 h after the start (End) were significant in both breeds, but S increased significantly more than B at and after 8 h from the Start. The TG in S tended to change more than in B, and CL and IGF-1 in both breeds changed continuously at similar levels. The TP in B tended to decrease more slowly and be lower than S. The change in NEFA, especially, suggests that nutritional status sensitively reflects genetic background.


Objective To establish an RP-HPLC method for simulaneous determination of chlorogenic acid and caffeic acid in Wuweixiaoduyin oral solution.Methods Irregular-H C18 column(4.6 mm×250 mm,10 μm) was used with acetonitrile-0.04% phosphoric acid solution(V∶V=12∶88) as the mobile phase at a flow rate of 1.0 mL·min-1.The detection wavelength was set at 327 nm and column temperature was 25 ℃.Results The calibration curve was linear in the range of 4.08-40.8 mg·L-1(r=0.999 6)and 0.156-1.56 mg·L-1(r=0.999 8)for chlorogenic acid and caffeic acid,respectively.The average recoveries were 99.7% and 99.3% with RSD of 0.52% and 0.27%(n=9),respectively.Conclusions The method is simple,accurate and reliable,which may be used for simultaneous determination of chlorogenic acid and caffeic acid in Wuweixiaoduyin oral solution.


Although advocacy both for clients and for the profession is essential for the future of counseling and counselors, advocacy for the profession has received little systematic attention. A national plan for advocacy is needed, the effectiveness of which depends on achieving consensus concerning professional identity, promoting a positive public image, establishing effective intraprofessional and interprofessional collaboration, and obtaining the participation of each counselor in advocacy activities. Specific professional advocacy skills and techniques are described.


This paper analyses the defect to conventional light polluted water treatment and the advantage and practicality of light polluted water treatment with permanganate, explicate the characteristic,principle and development of permanganate for removing polluted water treatment. And by the study to the feasibility of water quality from the part of Huanghe in Lanzhou and using this light polluted treatment, the results present that light polluted water treatment with permanganate is a new method of reducing water quality pollution from feeding water sources in Lanzhou.


Abstract—In this study, a general approach to the reliability based limit analysis of laterally loaded piles is presented. In engineering practice the uncertainties play a very important role. The aim of this study is to evaluate the lateral load capacity of free-head and fixed-head long pile when plastic limit analysis is considered. In addition to the plastic limit analysis to control the plastic behaviour of the structure, uncertain bound on the complementary strain energy of the residual forces is also applied. This bound has significant effect for the load parameter. The solution to reliability-based problems is obtained by a computer program which is governed by the reliability index calculation.


Dose-response curves have been run on isolated chains of rabbit aorta with acetylcholine alone and with acetylcholine in the presence of epinephrine, norepinephrine, or of serotonin. Under the latter conditions, when tone was present, the primary effect (observed with the lowest doses) of acetylcholine was that of relaxation. Higher concentrations then caused a variable contraction, the amplitude of which compared favorably with that seen with acetylcholine alone when no tone was present. Still higher concentrations of acetylcholine caused a relaxation once again. Both these dilator and constrictor effects of acetylcholine appeared to be relatively independent of the presence or concentration of serotonin.

Under these conditions, acetylcholine appears to act in a manner similar to that seen in perfused vascular systems and in vivo . These findings appear to resolve some problems concerning the effects of acetylcholine in vascular smooth muscle, and lead to further speculation as to the mechanism of its action.


Abstract Different (±)-4-(3/4-acetoxyaryl)-5-ethoxycarbonyl-6-methyl-3,4-dihydropyrimidin-2-ones have been synthesized and subjected to enantioselective deacetylation reactions mediated by different lipases in organic media. Novozyme 435 in tetrahydrofuran:diisopropyl ether was found to be the catalyst of choice for efficient enantioselective deacetylation of dihydropyrimidinones under study. Further, we discovered that lipase isolated from Pseudomonas aeruginosa can be used for selective acylation of secondary hydroxyl groups in nucleosides. This observation can be very useful for selective manipulation of different hydroxyl groups in nucleosides.


3D printing, as well as the numerous materials utilised in 3D printing, the qualities of them, usage procedure have become a prominent issue now in deciding the technical aspects, and this study paper is trying to explore these topics further. First and foremost, defining What exactly is 3D printing, what is the significance of 3D printing; then looking to the history of 3D printing and its applications as well as about 3D printing methods and the materials that are utilised in the manufacturing procedure of 3D printed products and showing that the selection of finest(best) materials for specific process(s) are utmost important. This paper also consider the benefits of different 3D printing processes as compared to additive manufacturing. a higher-resolution processing approach. As This press release includes information about the Accucraft iD-20 and other equipment. In International Manufacturing Technology, a number of additives are shown. A number of materials may be used in the manufacturing process, depending on the technique. Materials that are utilised in the process of putting together components


Imitation is a ubiquitous but complex phenomenon in the business world. Imitation has been examined in many theoretical studies that point to types of firms that are likely to be followed, and corr...


In this article, the analog of Torelli's theorem is proved for two-dimensional vector bundles with fixed determinant of odd degree over an arbitrary algebraic curve.


To study the association between oxygen free radical and fetal growth restriction. Maternay of blood was assayed in 70 pregnant women with fetal growth restriction(FGR group) and 70 normal pregnant women (control group). The SOD was tested by autooxidation system of pyrogallol. The GSH-Px was used by DTNB direct method. Improvement of the thiobarbituric acid fluorescence analysis of serum lipoperoxides(LPO). SOD and GSH-Px of FGR group was lower than that in control group. LPO of FGR group was higher than that in control group. [Conclusion] Oxygen free radical is positively related with fetal grouth restriction.


Different of large volume concrete members strength will result in changes of its bearing capacity, thus affect form removal age of structure. In this paper for the large volume concrete members, calculated the strength of the component through the concept of maturity.


The imperfection sensitivity of laminated cylindrical shells is considered--via the initial postbuckling analysis--on the basis of 3 different shell theories: Donnell (1933); Sanders (1963); and Timoshenko (1961). The procedure involves nonlinear partial differential equations, which are converted into a sequence of 3 linear sets. The equations are solved with the variables expanded in Fourier series in the circumferential direction and in finite differences in the axial directions. A general code is developed and used to study the effect of higher exactness of the shell theory on the sensitivity behavior, and in a parametric study of sensitivity of anisotropic angle-ply cylindrical shells.


A compound isolated from thiamine solutions brought to pH 5.0, 6.0 and 7.0 with IN NaOH or with O.1M phosphate buffer and heated in a boiling water bath open to air or in sealed tubes, or autoclaved at 121°C for 30 min, has been identified as 4-methyl-5-(β-hydroxyethyl) thiazole. Infrared, NMR and mass spectral data of this compound are presented and discussed.


The article examines the efforts of the executive and the legislature, i.e. the National Assembly at providing good governance against the backdrop of daunting challenge of insecurity in contemporary Nigeria. The paper employs secondary data to elicit necessary information to assist in its analysis and findings. Such data includes textbooks, journals, newspapers, magazines, periodicals etc. The findings are that both executive and legislative institutions pay lip service to quality governance. The two arms of government are tendentious towards kleptocracy. This development has compromised their efforts at fostering good governance. The work concludes on the need to convocate extra executive and legislature bodies (Sovereign National Conference) to discuss and analyse the contemporary questions with the aim of finding lasting solutions to the issues. The prognosis will not only be helpful to Nigeria but serves as a template for other African countries with similar issues.


Space-borne hyperspectral remote sensing imagery, supplying both spatial and spectral information for quantitative remote sensing monitoring, is easily polluted by noises from atmosphere, terrain etc. Based on spectral continuum removing and recovering, traditional fast Fourier Transform (FFT) was extended to Continuum Fast Fourier Transform (CFFT) to separate noise from target information in frequency domain (FD). Thus, low-pass filter for reserving useful information was designed for eliminating noise, with its cut-off frequency selected self-adaptively by optimal signal-tonoise ratio (SNR). Hyperion hyperspectral imageries of Beijing and Xinjiang China were singled out for noise removing to validate the filtering ability of the Continuum Fast Fourier Transform self-adapted by Optimal Signal-noise Ratio(CFFTOSNR) method with qualitative description and quantificational indexs, including mean, variance, entropy, definition and SNR etc. Experiment result shows that CFFTOSNR does well in reducing the gauss white noises in spectral domain and stripe and band-subtracting noise in spatial domain respectively, while the quantificational indexs of filtered imagery are all improved, with entropy of post-processed image obviously increased by 5 db.


The tourist industry needs an extensive information support to promote their activities. There are many existing information resources that have two main characteristics: focus on local initiatives and are very heterogeneous (using different data models, frequency of update etc). On the other hand users have their own requirements. They want to find interesting, attractive and credible information in a simple and fast way. The concept of SmartTouristData is developed as part of Smart Open Data and SDI4APPS interconnect a view of users and character of data sources. Our approach adds other components such as global and local open data sources and crowd-sourcing initiatives, social media (feedback from users) and the latest technologies and standards. The SmartTouristData provides benefits for two main groups. Users are able to find information in one place and to compare and evaluate information from more sources. They are appreciative of the simple and attractive interface for dealing with information. SmartTouristData also supports business subjects. An easy integration of project system to proprietary solutions, reusing and sharing of existing information resources and tools saves money and time, because it is not necessary to collect or buy data or develop new software. Moreover users are not forced to change or modify their ways of providing of information. SmartTouristData connects both main participants of the tourist industry by providing high-quality information, as satisfied and well-informed users will come back and recommend the destination.


Abstract In this paper, we argue that usage-based approaches to grammar, which specify how linguistic experience leads to grammatical knowledge through the interplay of cognitive, linguistic and social factors, have a central role to play in contributing to a unified theory of heritage language acquisition and processing with much greater explanatory adequacy. We discuss how this approach (1) offers solutions to long- standing problems in the field of heritage language research, (2) links phenomena that have been explained under diverging theoretical perspectives and (3) leads to new hypotheses and testable predictions about what we can expect heritage speakers acquire from their input. We conclude that usage-based approaches are crucial to move away from deficit-oriented perspectives on heritage grammars by taking into consideration how variation in sociolinguistic experience gives rise to differences in how heritage speakers acquire and use their language.


HONO and related parameters were measured at the foot of Mt. Tai in the summer 2018. 0-D box model coupled with the MCM were used to explore the budget of HONO, OH, ROx and NO3 radical chemistry. The homogeneous reaction of NO and OH has been adopted as the default HONO source in the box model and account for 12%-15%. The family constraint was used in this Model scenario to correct for interferences of NO2 measurements. Large amount of unknown source of HONO appeared especially on the noontime. Then many sources of HONO were discussed and added in the models. Corrected NO2, direct emission, heterogeneous reactions of NO2, and photolysis reactions were considered in the model. Another part of the manuscript studied the Radical chemistry. The authors gave very detailed consideration on the sources of HONO, and some corrected methods were suggested. These results is meaningful for the development of HONO investigation.


The processes of aggregation of anionic (SDS) and cationic (CTAB) molecules into supramolecular formations and the effect of carbon nanotubes on the processes were investigated by conductometry and tensiometry methods. Concentration dependences of the specific electrical conductivity and surface tension of aqueous SDS and CTAB dispersions and suspensions of carbon nanotubes of the carbon nanomaterial Taunit in these dispersions were obtained. A conclusion on the change in the conformation of CTAB micelles in the presence of carbon nanotubes was drawn. A significant increase in the packing density of CTAB molecules and their ordering in the monomolecular layer at the water-air interface in the presence of carbon nanotubes was shown. In particular, this makes it possible to control the properties of the surfactant surface layer by means of carbon nanotubes.


Accountants are either directly or indirectly partly responsible for corporate frauds, so it is important to know the underlying reasons why such unethical behavior occurred. This study aims to analyze the moderation impact of religiosity and gender on the relation between love of money with student's ethical perception. There were 144 questionnaires from accounting students. As hypothesized, the results of the study revealed love of money have a negative impact to student's ethical perception. The interaction between intrinsic religiosity and love of money are able to weaken the negative effect of love of money to student's ethical perception, however the extrinsic religiosity is vice versa. Gender has no significant effect on love of money relationship with ethical perception.


Human interference in production systems becomes feasible through the use of specific devices that, among other functions, allow the monitoring, control and optimization of processes. One of the drawbacks encountered in the sugar and ethanol industry is the lack of instruments for the measurement of the °Brix concentration in sugarcane that are low-cost and non-destructive. The measurement and monitoring of the °Brix concentration in the cane are necessary to identify the appropriate time for harvesting in order to reach the peak sucrose content in the cane, obtaining maximum yield from a given crop. Based on several measurement devices available in the current market that involve non-destructive technologies for the monitoring of physical-chemical properties of food, this paper proposes a new low-cost meter to measure °Brix in sugarcane. The device uses the continuous wave technique consisting of two piezoelectric transducers (signal transmitter and receiver), a pulse generator, an instrumentation amplifier with a bandpass filter and an amplitude meter. The developed measuring instrument is feasible and represents a promising alternative for the sugar and alcohol industry.


We show that, for certain types of rigid analytic varieties and constructible -adic sheaves on , one has lim . As an application we obtain that, for an algebraic variety and associated rigid analytic variety rig ,t he -adic cohomology of and rig agree.


The biosynthesis of DNA, RNA, proteins and lipids in the presence of antiserum to sulfolipids was investigated by studying the incorporation of radiolabelled precursors like 3H-thymidine 14C-uracil, 14C-leucine and 14C-Acetate into their respective macromolecules. Antiserum to sulfolipids had a inhibitory effect on the biosynthesis of all these components. Antiserum also exhibited a growth inhibitory effects as compared to normal serum.


This thesis uses the city of Dar es Salaam as a prism for exploring the intersection of the Cold War and decolonisation with political life in post-colonial Tanzania. By deconstructing politics in the city through transnational and international approaches, it challenges prevailing narratives of the global Cold War, African liberation, and the contemporary Tanzanian history. In the decade after Tanzania became independent in 1961, President Julius Nyerere's commitment to the liberation of Africa transformed Dar es Salaam into a cosmopolitan epicentre of international affairs in Africa, on the frontline of both the Cold War and decolonisation. In shifting the focus away from superpower relations and the paradigm of the nation-state, this thesis shows how African politicians exercised significant influence over Cold War powers, but also how the global context pushed Nyerere's government into increasingly authoritarian methods of rule. The political geography and public sphere of Dar es Salaam, as a 'Cold War city', provides an interpretative lens through which diverse but ultimately entwined narratives are understood. These include the international rivalry between East Germany and West Germany; the politics of the exiled Mozambican liberation movement, FRELIMO; the local experience of the global '1968'; and thecourse of elite politics in a critical period in the Tanzania's recent history. This multilateral history is made possible by a multiarchival approach, to shed light on developments in Dar es Salaam from multiple, triangulated perspectives.


This chapter foregrounds the essential role of critical analysis in an era when facts, feelings, opinions, news, and propaganda have become increasingly hard to disambiguate. Carla Della Gatta explains that Shakespeareans are in an excellent position to help students navigate this terrain, thanks to our field's "lengthy, cross-cultural, and international history of determining, disputing, and reinterpreting facts," a habit that can be put to especial use in identifying various modes of misinformation and bias. This chapter relates exercises in introductory scholarly editing and comparative theatrical/film analyses that enable students to be makers, not just consumers, of knowledge. Putting primary sources directly in students' hands empowers them to apply rigorous analysis, solve interpretive problems, and hone their confidence in questioning established authority and venerated "facts." The payoffs span from the understanding of Renaissance literature to informed encounters with "fake news," biased sources, or unresearched content.


Through ali periods, from the Middle Ages to this day, Slovenian music has been developing parallel with that of Western Europe. Hence, there arises the question of historical relations: what has it received from, and what has it - to the best of its abilities, and through its representatives and institutions - contributed to this music. The aim of the text is to introduce Slovenian music in its historically national (and therefore also prenational) role, and after its originality seems to have exceeded expectations, in its ascension to European or, more directly, Central European standards - individually, creatively, interpretationally, and institutionally.


Abstract Using the lenses of humor studies and narrative analysis, this paper discusses the stand-up comedy of Vivek Mahbubani, a Hong Kong-born stand-up comedian of Indian descent. Mahbubani uses humor about ethnicity-related issues to highlight the irrationality of racial discrimination and stereotypes. Specifically, Mahbubani challenges people's preconceived ideas about the speakerhood of Cantonese and the local identity. The present study demonstrates how this comedian has effectively built humor into his narrative as a response to oppression, thus engaging the local, ethnically Chinese audience to reflect on the social and ethnic tension felt by minorities in Hong Kong. This study further argues that Mahbubani's comedy reflects a more general trend in stand-up comedy: humor as a vehicle for a more inclusive and progressive grand narrative across different cultures; this trend stands in stark contrast to earlier ethnic jokes that often made minorities the target of verbal humor.


The aim of this study was to explore the benefits of data integration from different platforms for single nucleus transcriptomics profiling to characterize cell populations in human liver.


This study examines indigenous women's involvement in state-sponsored antiviolence responses since the 1980s. It focuses on three fields of political engagement: (1) the Canadian state politics of family violence; (2) the Native Women's Association of Canada's (NWAC) "Sisters in Spirit" (SIS) initiative and the politics of missing and murdered Aboriginal women and girls; and (3) the politics of prostitution and the Missing Women Commission of Inquiry. Overall, I argue that despite navigating a complex and colonizing political terrain largely out of their control, indigenous women have been "warrior women," advancing strong anti-colonial anti-violence responses that support the end goal of ending violence against indigenous women and girls in Canada. I also explore how indigenous women have sometimes employed political discourses and strategies that while appearing to offer a valid pathway of resistance, replicate dominant discourses and strategies and, thus, serve to undermine these efforts by securing the colonial Canadian state's authority over indigenous peoples and territories and, therefore, the persistence of violence against indigenous women and girls in Canada. To reinforce both of these claims, this study


This paper examines the impact of reform policies on the work of Chinese teachers. It explores the policy context in which a fragile teaching profession attempts to develop and discusses the dynamics of interacting societal forces that have created the dilemmas for the teachers. The authors argue that while the continual implementation of reform policies has fostered a new outlook in Chinese schools, calls for profound change in schooling have caused much anxiety among teachers. The teachers' anxiety stems from the incongruence between their professional outlook, which is intimately linked to student academic achievement, and the dictates of state reform measures, which seek to broaden the conception of education to include other areas of human development. Throughout the years of reform, teachers have had to stretch their professional capacity in order to satisfy competing demands engendered by reform measures and educational reality. It is in the tensions caused by the implementation of reform policies that the humanism of teacher professionalism is magnified. In this paper, the authors discuss the educational and social issues that surround the teachers' preference for conventional practices.


The SRS at Daresbury has been upgraded by the addition of quadrupoles which reduce the emittance by a factor of 15. In order to do this without disturbing the beamlines, all 16 straight sections were rebuilt. Additional sextupole and octupole magnets were included, as was additional pumping capacity. Completely new beam monitor and vertical steering systems have been incorporated. The SRS was shut down on 1 October 1986 and, after recommissioning, regular scheduled operation for users at the rate of nearly 6000 h per year has been in effect again since June 1987. Scheduled operation is at 2 GeV with the 5T wiggler operational. The gain in brightness is as expected. Maximum beam current at 2 GeV is now 280 mA. Beam lifetime is 20 h at 200 mA. Diffraction patterns of small angle scattering from muscle obtained with an electronic area detector show that with the improved brilliance, diffraction lines corresponding to spacings exceeding 15 000 A can be clearly resolved. Work is about to start on the provision...


The transport behaviors of MoS2 field effect transistor (FET) with various channel thickness are studied. In a 12 nm thick MoS2 FET, a typical switching behavior is observed with Ion/Ioff ratio of 106. However, in 70 nm thick MoS2 FET, the gating effect weakens with a large off-current, resulting from the screening of gate field by the carriers formed through ionization of S vacancies at 300 K. Hence, when the latter is dual-gated, two independent conductions develop with different threshold voltage (VTH) and field effect mobility (μFE). When the temperature is lowered for the latter, both the ionization of S vacancies and the gate field screening reduce, which revives strong Ion/Ioff and merges the two separate channels to one. Thus, only one VTH and μFE are seen from the thick MoS2 FET when the temperature is less than 80 K. The change of the number of conduction channel is attributed to the ionization of S vacancies that leads to temperature-dependent intra and inter layer conductance and the attenuation of electrostatic gate field. The defect-related transport behavior of thick MoS2 enable us to propose a new device structure that can be further developed to a vertical inverter inside a single MoS2 flake.


The Affective Behavior Analysis in-the-wild (ABAW2) 2021 Competition is the second Competition -following the first very successful ABAW Competition held in conjunction with IEEE Conference on Face and Gesture Recognition 2020- that aims at automatically analyzing affect. ABAW2 is split into three Challenges, each one addressing one of the three main behavior tasks of Valence-Arousal Estimation, Seven Basic Expression Classification and Twelve Action Unit Detection. All three Challenges are based on a common benchmark database, Aff-Wild2, which is a large scale in-the-wild database and the first one to be annotated for all these three tasks.In this paper, we describe this Competition, to be held in conjunction with the International Conference on Computer Vision (ICCV) 2021. We present the three Challenges, with the utilized Competition corpora. We outline the evaluation metrics and present both the baseline systems and the top-5 performing teams' per Challenge; finally we present the obtained results of the baseline systems and of all participating teams. More information regarding the Competition, the leaderboard of each Challenge and de-tails for accessing the utilized database, are provided in the Competition website: https://ibug.doc.ic.ac.uk/resources/iccv-2021-2nd-abaw/.


Through the renovation and expansion of the Getty Villa, Machado and Silvetti Associates reconsiders the relationship between the new and the old. The new Getty Villa neither dominates the existing building nor becomes another post-modernism replica. Instead, through elaborate spatial organization, intricate materials and modern details, the renovation gives the old building a new life.


OBJECTIVE To understand the omissions and quality of report card on the birth defects in Yichang city between 2008 and 2010.METHODS We investigated the omissions and quality of report card on the birth defects in midwifery agency of Yichang city on the basis of the National monitoring project of health of mothers and children.RESULTS The leakage rate was 7.49%,and the mistaking rate was 1.26% in the tables and cards.The two rates decreased year by year.CONCLUSION The fundamental guarantee of improving the quality of monitoring in the birth defects was the strengthening of management and supervision,and the raising responsibility of medical staff.


Poor influence of social circumstances is the most important reason which youngsters commit an offence increasingly. Of many mainly factors, there are changes of valuble outlook; poor propagation; bad general mood of society; difficulties and pressure of employment; vestiges of feudal dross culture etc, we must strengthen social education among youngsters for them.


In this note, we prove that for any ${\it\nu}>0$, there is no lacunary entire function $f(z)\in \mathbb{Q}[[z]]$ such that $f(\mathbb{Q})\subseteq \mathbb{Q}$ and $\text{den}f(p/q)\ll q^{{\it\nu}}$, for all sufficiently large $q$.


To highlight the fishery in monsoon, an attempt has been made In this paper to evaluate the impad of monsoon
fishing on the exploited marine fish stocks in the west coast of India and the trends In the production of various group
in different seasons discussed.
Except in Kerala where monsoon fishing is intensive due to the Mud Bank fishery and trawling off Sakthlkulangara
and Kochi, in the rest of the coast fishing adivitics are not as intensive as in Kerala during monsoon. The major
gears used during monsoon are trawls and ring seines in Kerala


The subject of the gradation thesis is pointing at an object with the robotic arm Katana. The robot autonomously detects the object in its environment, using a camera and points at it with his end effector.
The system was developed in Robot Operating System, a software framework for developing robotics software. The robotic arm, alongside its environment, was simulated using Gazebo, a three-dimensional multi-robot simulator. The objects on the table were detected with the usage of the depth sensor Kinect, which provides depth data in the form of a point cloud.
After the object is detected, the searches for an inverse kinematics solution to move the end effector towards the object, pointing at it. After such a solution is found, a motion planning algorithm for moving the robotic arm from its current state, to the desired one is run. Lastly, Gazebo plays the joints' trajectories, thus simulating the robotic arm's movements.


Based on the survey on the international and domestic designs of petroleum driller cab,in the concept of human-oriented design,combined with the theories of Ergonomics,this article presents the analysis of the display and the manipulating units of the driller control systems,thus puts forward the appropriate space measures which are easy to manipulate.


The title compound, C10H11ClN2O2, features an almost planar Car—N(H)—N=C(Cl) unit [torsion angle = 0.8 (1)° whose phenyl substituent is almost coplanar with it [dihedral angle = 2.8 (2)°]; this unit is slightly twisted with respect to the carboxyl –CO2 fragment [dihedral angle = 10.3 (2)°]. In the crystal, the amino group acts as a hydrogen-bond donor to the carbonyl O atom of an adjacent molecule; the hydrogen bond generates a helical chain that runs along the b axis of the monoclinic unit cell.


Final work talks about the obtaining of funds from EU funds in agriculture, more specifically the creation of natural apple cider vinegar. In it's essence the work tells how to get through all the stages from the idea to realization, with the options that are available to us today. Making Apple Cider vinegar is a complex, long-term process that is better explained in this paper. The work is more conceived on the realization of getting incentives from the agriculture activities. Tells how a physical person from their ideas can make a profit with the help of, without the large initial costs. Therefore, the work consists of several units. In the introduction you are talking in General as all work includes, Furthermore, why is Apple Cider vinegar the theme of this work, it is important to mention the family farm (OPG). One part of the work refers to the family farm, why is the cost effective physical persons, what the possibilities are with open family farms, and at the end of the work we should remember how to log on to the contest and how to realize.


who developed as a student group at the Sorbonne in 1933 under the leadership of Professor Gustave Cohen. They drew their name from the first play they performed, the thirteenth-century Miracle of Théophile by Rutebeuf, and they continued to perform until 1952 despite the continuous change in membership due to the Second World War and its aftermath. Solterer focuses her study on the history of the troupe and its leader, following their shifting political positions as they attempt to navigate the varying French governments in power. The central figure for Solterer is Gustave Cohen, whose French nationalism she believes was driven by the fact that, as a Belgian Jew, he was always doubly an outsider. As a contrast to Cohen's flight to the United States during the Second World War and his subsequent conversion to Catholicism, Solterer spends her sixth and final chapter on Moussa Abadi – a Syrian Jew and one of the early actors in the Théophiliens – who remained in Nice and formed a resistance network that saved Jewish children from deportation. Yet in the lives of both these men, as well as in the performances of the Théophiliens as a group, Solterer sees the relationship with medieval theatre as paramount. Solterer argues that the 'role playing' experienced by Cohen and his Théophiliens as they performed medieval plays shaped their reactions to the political situation as it unfolded from 1933 to 1952, even as she discusses each government's successive attempt to co-opt medieval history and theatre for its own political agenda. Although she makes Cohen's republican values clear, she is strangely vague about whether she believes that the Théophiliens who performed during Vichy were allowing themselves to be co-opted, were attempting to undermine the politics of the regime, or were in essence collaborators themselves, and she seems unwilling to theorize about the ways in which the Théophiliens' political allegiances may have been due specifically to their medieval expertise, largely failing to place them within the context of early twentieth-century French theatre or medieval revivals. The argument that role playing aided the Théophiliens during the war – particularly those who were Jewish and needed to avoid deportation – has obvious potential, but Solterer uses no role-playing or performance theory. That Moussa Abadi made use of role playing in his resistance work is transparent and excellently argued, but the importance of the medieval aspect of his role playing remains uncertain, and another possible context for her work – the use of theatre by Jews during the Second World War – is disregarded. Despite these omissions, Solterer deserves our thanks for bringing to light the work of Cohen and the Théophiliens in such a detailed and fascinating study.


The robust H∞ control problem for nonlinear systems with uncertainties and impulsive effects is considered. Based on the Takagi-Sugeno (T-S) fuzzy model and the parallel distributed compensation (PDC) technique, some sufficient conditions for robust H∞ stability are proposed and are expressed in terms of linear matrix inequalities (LMIs). Numerical example shows the control algorithm is feasible for practical application.


Objective To evaluate the value of anti-ferritin light chain(FTL) autoantibody in the diagnosis of common malignant gastrointestinal tumors.Methods The serum levels of anti-FTL autoantibody in different groups,including a variety of gastrointestinal tumors(250 esophageal cancer patients,250 gastric cancer patients,250 primary hepatocellular carcinoma(HCC) patients,chronic liver diseases patients(120 hepatitis B patients,54 hepatitis C patients,58 liver cirrhosis patients),and 113 normal individuals,were measured with enzyme-linked immunosorbent assay(ELISA),then the content and the positive rate of anti-FTL autoantibody in different groups were analyzed and compared.Results 1.The anti-FTL autoantibody levels in gastrointestinal tumor groups were all significantly higher than normal individuals(all P0.001).Compared with esophageal cancer patients or gastric cancer patients,the anti-FTL autoantibody levels in primary hepatocellular carcinoma patients were significantly higher(all P0.001).2.The anti-FTL autoantibody levels in primary hepatocellular carcinoma patients were higher than those with chronic liver diseases(P=0.001).Further more,the anti-FTL autoantibody levels in those with chronic liver diseases were significantly higher than that of normal individuals(P=0.000).3.The positive rate of anti-FTL autoantibody in cancer groups was significantly higher than that of normal subjects(all P values were less than 0.001).4.The sensitivity of anti-FTL autoantibody in the detection of gastrointestinal tumors(esophageal cancer,gastric cancer and HCC)was 46.8%,48.4%,and 61.6%,respectively,and the specificity was 99.1%.Conclusion The concentration of anti-FTL autoantibody increases in gastrointestinal tumor patients and the increase is significant for the the diagnosis of common malignant gastrointestinal tumors.


The Federal prisons in Nigeria are charged with the uncompromising responsibility of ensuring that offenders are reformed and rehabilitated. Although prisons in recent times are considered as centres for rehabilitation, some factors have made this difficult in Nigeria. In view of this background, this study has empirically examined the rehabilitative and reformative roles of Federal prisons in Kogi state. The findings of the study have clearly shown that despite the official claims that these prisons are operating on the principles of rehabilitation and reformation, abundant evidence indicate that these institutions are still largely retributive in nature. Retributive traits are expected to be similar in other Nigerian prisons. The study made useful suggestions that could ameliorate this ugly trend. Keywords: Rehabilitation, Rehabilitation Programmes, Retribution, and Recidivism


An automatic method based on MD simulations was developed for detecting and tracing the boundaries of metastable states of superheated crystal and supercooled liquid. The main criterion of the detection of early nucleation of new phase is the self-diffusion coefficient temperature dependence. The scanning for nucleation events is performed at continuous temperature change. The set of independent nucleation events at a given pressure allows evaluation of temperature dependence of specific nucleation frequency. The collection of a large number of these calculations allows accurate approximation of pressure and temperature dependence of the specific nucleation frequency in both directions between phases. This dependence allows estimating the behavior of the free energy in the region between superheating and supercooling curves. In addition, dependence of nucleation frequency on pressure and temperature provides an opportunity to integrate the probability of nucleation under dynamic loading and subsequent release and thus to determine the likelihood of the crystallization and melting. The technique was applied to tin. MD simulation was carried out with the help of the EAM interatomic potential, well reproducing the properties of BCC phase.


The third edition encompasses disorders of hemostasis. It begins with a review of the history of the development of knowledge about this subject and with a chapter on the laboratory approach to hemostatic disorders. The rest of the volume is devoted to summaries of specific patient problems, their pathogenesis, diagnosis and therapy.


Urbanization, which has been one of the most significant parameters of changing social structure since the beginning of 20th Century, has also brought urban transport problems. To cope with these transport problems, traditional vehicle priority policies must be abandoned; modern policies taking individual mobility into consideration must be considered. To increase that mobility, urban rail system projects, which have long been implemented in developed countries, have become widespread in Turkey. These projects that have become the main transport system in many Metropolitan Municipalities have recently begun to be implemented in middle-sized cities. The Erzincan street tramway project, which is the subject of the study, aims to increase the mobility of the individuals in the city and to solve the problems experienced in the traffic. The transportation master plan and feasibility study prepared for Erzincan city aims to apply the street tramway with the aim of developing a modern transportation policy. This article explains the evolving role of rail systems in transport policies used as a tool of social and economic development through the Erzincan Transportation Master Plan and Rail System Feasibility data. In addition to this, the said application are set forth examples of the directions that are the medium-sized cities in Turkey.


The electronic structure and absorption spectra of the title complexes FePz(dtn) 4 and FePz(dcdtn) 4 compared with FePc are investigated by the geometry optimizations in the UHF\|ZINDO/1 and the CI calculations of multi\|configurations in the RHF\|ZINDO/S method. It has been found that the molecular ground state of three complexes is spin triplet state, and the binding energy of the molecule and the net charge of the central Fe is incremental in the order FePcFePz(dtn) 4FePz(dcdtn) 4. The wavelength and oscillator strength of calculated transition is in conformity with the observed absorption spectra in the solutions. The energy of the Q\|band is incremental in the order FePcFePz(dtn) 4FePz(dcdtn) 4.


Background: The current standard of care for eligible newly diagnosed multiple myeloma (MM) patients is induction therapy with novel agents followed by high dose chemotherapy and autologous stem cell transplant (ASCT). The International Myeloma Working Group proposed the Revised International Staging System (R-ISS) based on the presence of adverse chromosomal abnormalities (CA) detected by FISH (t(4;14), t(14;16) or del17p), in combination with ISS and LDH at diagnosis. However, there are a limited number of studies that have validated this risk model in the transplant and novel agents setting. Aims: To determine whether R-ISS is an appropriate risk-model for estimating overall survival (OS) and progression free survival (PFS) for transplant-eligible MM patients. Patients and Methods: We retrospectively studied a cohort of 519 MM patients who received novel drugs in the induction and subsequently underwent ASCT at Mayo Clinic Arizona from 2005 to 2014. In all, 95 patients met the inclusion criteria: comprising complete data at diagnosis (ISS, serum LDH level, and CA by FISH). The primary endpoint was OS from SCT and the secondary end point was PFS from ASCT. R-ISS groups were defined as described by Palumbo et al. J Clin Oncol. 2015; 33(26):2863-2869. Results: There were 50 (52.6%) men and 45 (47.4%) women who underwent ASCT in this period, with a median age at the time of transplant of 66-years-old (range, 36-78). There were 27 patients (28.4%) with high-risk CA: 12 patients (12.6%) with del17p; 11 patients (11.6%) with t(4;14); and 6 (6%) with t(14;16). In addition, 8 patients (8.5%) had high LDH levels and 9 patients (9.5%) presented with renal impairment at diagnosis. The patients were staged at diagnosis according to the three R-ISS groups: 44 patients (46.3%) had stage I, 26 (27.4%) had stage II, and 25 (26.3%) had stage III. CyBorD was the preferred induction regimen which was received by 42 patients (44%). There were 14 patients (15%) who received at least 2 lines of induction. All patients were in at least partial response (PR) at the moment of transplant: 32 in complete response (CR), 32 in very good partial response (VGPR) and the remaining 31 in PR. The response achieved at day +100 after ASCT improved, with 54 patients (57%) in CR, and only 18 patients (19%) in PR. After a median follow-up of 61 months (range, 14-135), median OS from SCT was 108 months (95% CI: 85 - 132 months) and the median PFS was 45.4 months (95% CI: 31.1 - 53.8 months) in the whole series.MM patients with R-ISS III had a significantly shorter median OS compared to patients with R-ISS II or R-ISS I (32.1 months vs. 94.7 months vs. not reached, respectively, P vs. 35.7 months, respectively, ( P =0.2). Renal impairment at diagnosis, IgA subtype, ≥ 2 lines of induction treatment, and less than CR achieved at day +100 after ASCT were also associated with significantly inferior OS. Multivariate analysis selected R-ISS as an independent predictor for OS (HR: 2.3, 95% CI: 1.1-4.8; P =0.03), as well as ≥ 2 lines before ASCT. CR at day +100 after ASCT was the most important independent factor for predicting PFS (HR: 0.4; 95% CI: 0.2-0.6; P Conclusion: R-ISS assessed at diagnosis was an independent predictor for OS after ASCT in our series, with median OS for the different R-ISS groups comparable to those reported by Palumbo et al. in their subgroup of younger patients. Thus, this study lends further support for the R-ISS as a reliable prognostic tool for estimating OS in transplant-eligible MM patients. In addition, new treatment approaches are needed for the high-risk patients (R-ISS III) with a median OS of 2.5 years. Disclosures Reeder: Millennium: Research Funding; BMS: Research Funding; Celgene: Research Funding; Novartis: Research Funding. Mikhael: Abbvie: Research Funding; Onyx: Research Funding; Sanofi: Research Funding; Celgene: Research Funding. Bergsagel: Amgen, BMS, Novartis, Incyte: Consultancy; Novartis: Research Funding. Stewart: celgene: Consultancy. Fonseca: Janssen: Consultancy; Celgene: Consultancy; Sanofi: Consultancy; Novartis: Consultancy; Bayer: Consultancy; AMGEN: Consultancy; AMGEN: Consultancy; AMGEN: Consultancy; Patent: Patents & Royalties: Prognostication of MM based on genetic categorization of FISH of the disease; AMGEN: Consultancy; Millennium, a Takeda Company: Consultancy; Janssen: Consultancy; Sanofi: Consultancy; Patent Pending: Patents & Royalties: The use of calcium isotopes as biomarkers for bone metabolisms; Novartis: Consultancy; Patent: Patents & Royalties: Prognostication of MM based on genetic categorization of FISH of the disease; Millennium, a Takeda Company: Consultancy; Millennium, a Takeda Company: Consultancy; Bayer: Consultancy; Celgene: Consultancy; Patent Pending: Patents & Royalties: The use of calcium isotopes as biomarkers for bone metabolisms; Patent: Patents & Royalties: Prognostication of MM based on genetic categorization of FISH of the disease; Patent Pending: Patents & Royalties: The use of calcium isotopes as biomarkers for bone metabolisms; BMS: Consultancy; Millennium, a Takeda Company: Consultancy; BMS: Consultancy; Patent: Patents & Royalties: Prognostication of MM based on genetic categorization of FISH of the disease; Patent Pending: Patents & Royalties: The use of calcium isotopes as biomarkers for bone metabolisms.


Trophoblast cell surface antigen 2 (TROP2), reported to be overexpressed in several types of cancer, is involved in cell proliferation, invasion, metastasis, and poor prognosis of many types of cancer. Previously, a highly sensitive anti-TROP2 monoclonal antibody (clone TrMab-6; mouse IgG2b, κ) was developed using a Cell-Based Immunization and Screening (CBIS) method. TrMab-6 was useful for investigations using flow cytometry, western blot, and immunohistochemistry. The aim of the present study was to investigate whether TrMab-6 possesses in vitro antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) activities or in vivo antitumor activities using mouse xenograft models of TROP2-overexpressed CHO-K1 (CHO/TROP2) and breast cancer cell lines, including MCF7, MDA-MB-231, and MDA-MB-468. In vitro experiments revealed that TrMab-6 strongly induced ADCC and CDC activities against CHO/TROP2 and the three breast cancer cell lines, whereas it did not show those activities against parental CHO-K1 and MCF7/TROP2-knockout cells. Furthermore, in vivo experiments on CHO/TROP2 and MCF7 ×enografts revealed that TrMab-6 significantly reduced tumor growth, whereas it did not show antitumor activities against parental CHO-K1 and MCF7/TROP2-knockout xenografts. The findings suggest that TrMab-6 is a promising treatment option for TROP2-expressing breast cancers.


There is increasing evidence that carbohydratecontaining components of cellular membranes play a role in recognition phenomena. Attention has centred on glycoproteins and glycolipids as cell membrane receptors for extrace~lular signals [ 1,2]. ~thou~ it is implied that these glycosylated species function in the transmission of signals across the surface membrane, the exact nature of this transmission and the means by which it influences cellular events is little understood 131. Many investigations have shown that carbohydrate-binding proteins (lectins) are located within a wide variety of cells and membranes (reviews [4-61). These results have raised the possibility that endogenous lectins could be involved in cellular communication. It would like to develop this suggestion further and put forward a model in which an underlying principle governing recognition events both between cells and within cells is the specific interaction of a melnbrane-bound lectin with its receptor.


Document Retrieval has seen significant advancements in the last few decades. Latest developments in Natural Language Processing have made it possible to incorporate context and complex lexical patterns to document representations. This opens new possibilities for developing advanced retrieval systems. Traditional approaches for indexing documents suggest averaging word and sentence encoding to form fixed-length document embeddings. However, the common bag-of-word approach fails to incorporate the semantic context, which can be critical for understanding document-query relevancy. We address this by leveraging Bidirectional Encoder Representations from Transformers (BERT) to create semantically rich document embeddings. BERT compensates the limitations of the Term Frequency Inverse Document Frequency (TF-IDF) by incorporating contextual embeddings. In this paper, we propose an ensemble of BERT and TF-IDF for a document retrieval system, where TFIDF and BERT together score the documents against a query, to retrieve a final set of top K documents. We critically compare our model against the standard TF-IDF method and demonstrate a significant performance improvement on MS MARCO data (Microsoft-curated data of Bing queries).


What factors determine demand for consumer goods? Using the demand for lottery tickets as an example, the article discusses an approach from consumption sociology which highlights the imaginative quality of goods. The theory, based on Campbell (1987), explains consumption from the consumer's attempt to realize fantasies stemming from socially constructed daydreams. On the basis of survey data, the study shows that lottery players who have daydreams and fantasies on winning large amounts of money spend more money for tickets and play more regularly. From this perspective, demand for lotteries is explained by its potential to create and maintain dream worlds which players find enjoyable to indulge in. With the ticket, lottery players buy an imagined dream on what to do with large amounts of money and on how this would transform their lives. The article concludes with a discussion on how this theory can be applied to study phenomena beyond the domain of consumption.


Human subjects ingested daily 5- to 20-mg doses of technical DDT, p,p′-DDE, or p,p′-DDD for 81 to 183 days. Serum and adipose concentrations of DDT and DDT metabolites in response to these dosings have indicated that the initial dechlorination of DDT is of critical importance to its metabolic fate. Conversion to the saturated p,p′-DDD makes possible further degradation to the readily excreted p,p′-DDA. Dehydrochlorination, on the other hand, yields p,p′-DDE, a stable metabolite that is avidly retained in adipose storage. In two subjects ingesting technical DDT, conversion to DDE has been extremely limited, while conversion to DDD has been regularly demonstrable during and after dosing. Tissue stores of p,p′-DDE in general population probably originate mainly from preformed dietary p,p′-DDE in the diet, rather than from p,p′-DDT.


ABSTRACT Ethyl cyanoacrylate polymerizes at room temperature, and is often used as an adhesive in many areas for a wide variety of applications. In this study, the possibility of using poly(ethyl cyanoacrylate) in the field of wood modification was investigated. For this purpose, Scots pine (Pinus sylvestris L.) and Oriental beech (Fagus orientalis) samples were impregnated with poly(ethyl cyanoacrylate) that was synthesized using acetone. Modified samples were characterized by Thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), and Scanning Electron Microscopy (ESEM). Decay performance was done with white rot fungus (Trametes versicolor (L: Fr.) Pilat. (FFPRI 1030)) for beech wood and brown rot fungus Coniophera puteana for pine wood; the European standard EN113 FTIR analysis indicated that PECA could appreciably alter the chemical structure in modified wood. Thermal changes in modified wood were be minor compared to those of untreated wood. Samples treated with PECA had significantly lower mass losses than untreated samples as a result of fungal exposure to Coniophora puteana and T. versicolor.


Species‐orientated conservation programs accord priority to selected species based on values of different kinds, a process which can conflict with ideals and necessitate compromise with them in determining how restricted logistic support for conservation is to be allocated. The importance of utilitarian and intrinsic values is explored in relation to setting such priorities for insects, and approaches to selecting or nominating priority species are discussed.


The utility model relates to a self-lubricating guiding device with a compensation function, which comprises a guiding shaft and a self-lubricating bearing, wherein, the guiding shaft is coaxially arranged in the self-lubricating bearing; a bearing inner ring and a bearing outer casing are sequentially sleeved on the self-lubricating bearing; and an elastic material layer is arranged between the bearing inner ring and the bearing outer casing. The self-lubricating guiding device at least has the advantages of self-lubricating guiding function, oil leak potential hazard prevention, cost conservation, compensation function, dead locking prevention, accuracy in guiding, high lateral rigidity, and reliability in operation.


of incompetence or venality. But in spite of this distrust we are almost altogether dependent upon them for our knowledge of widely interesting events. As the organization of society becomes more complex and far-reaching, the importance of the newspaper in the distribution of intelligence inevitably increases. The modern social man finds himself in much the same position as the ancient individual who first discovered confusion in his sensations and believed


Cluster analysis is important in scientific and industrial fields. In this study, we proposed a novel chaotic biogeography-based optimization (CBBO) method, and applied it in centroid-based clustering methods. The results over three types of simulation data showed that this proposed CBBO method gave better performance than chaotic particle swarm optimization, genetic algorithm, firefly algorithm, and quantum-behaved particle swarm optimization. In all, our CBBO method is effective in centroid-based clustering.