In the article the issue on effectiveness of new criminal procedure form introduced by the Federal Law from 04.03.2013, no. 23-FZ – abbreviated inquiry is viewed. According to the opinion of authors, effectiveness of any procedure is determined by its ability to reach the purpose of criminal proceeding, stipulated in section 6 of the Criminal Procedure Code of the Russian Federation. Analysis of the grounds, conditions, procedures of an abbreviated inquiry, rules of evidence used in this form of justice, allows authors to draw a conclusion about non-compliance of the procedure of abbreviated inquiry procedure with the criteria of effective judicial procedure, and hence the inability of this procedure of the defense of rights of parties to a trial. In this regard, the authors put forward a number of proposals on improving the procedure of abbreviated inquiry.


Foraging movements of Adelie penguins are constrained both by environmental con- ditions (e.g. sea ice cover) and life history factors (e.g. regular offspring provisioning). We describe within season changes in foraging range, trip duration and body condition of Adelie penguins nest- ing at Bechervaise Island, East Antarctica, in the context of these constraints. Penguins were satellite tracked over multiple seasons during the incubation, guard, creche and pre-moult phases of their annual cycle. They ranged farthest during incubation when sea ice was extensive and shortest dur- ing the guard stage when chicks were small and sea ice limited in extent. Prior to their annual moult the birds foraged hundreds of kilometres to the west and east of their breeding sites. A recurrent polynya facilitated access to the sea early in the season when ice cover was extensive. Kernel analy- ses showed that penguins foraged most intensively close to the colony, along submarine canyons and at the continental shelf break. Increases in foraging range, as the chick rearing period progressed, were consistent with changing energy requirements of adults and chicks and likely intraspecific competition. Whilst provisioning their offspring, penguins adopted a variable combination of time minimising and food maximising foraging behaviour in which choice of foraging rule was determined largely by adult body condition.


Cloud computing lacks control over physical and logical aspects of the system, which imposes profound changes in security and privacy procedure; hence, it needs a high level of security. Currently, many researchers and developments are being done to provide client service-level agreements regarding security issues. These researchers are attracted towards biometrics and its security applications, since it is based on biometric traits, thus providing a high level of security. Due to biometrics' benefits and cloud advantages, the collaboration of cloud and biometrics have open up wide areas this field. This chapter discusses some case studies of integration of biometrics and cloud computing.


Local optimization algorithms, when they are optimized only for speed, have in certain situations an unpredictable behavior: starting points very close to each other lead after optimization to different minima. In these cases, the sets of points, which, when chosen as starting points for local optimization, lead to the same minimum (the so-called basins of attraction), have a fractal-like shape. Before it finally converges to a local minimum, optimization started in a fractal region first displays chaotic transients. The sensitivity to changes in the initial conditions that leads to fractal basin borders is caused by the discontinuous evolution path (i.e. the jumps) of local optimization algorithms such as the damped-least-squares method with insufficient damping. At the cost of some speed, the fractal character of the regions can be made to vanish, and the downward paths become more predictable. The borders of the basins depend on the implementation details of the local optimization algorithm, but the saddle points in the merit function landscape always remain on these borders.


ABSTRACT Aim: Recently new chemotherapeutic agents for metastatic breast cancer (MBC) have been developed and introduced to bedside. Some of them improved overall survival (OS) in clinical trial, however, it is still unclear those agent(s) improve OS of MBC patients in real world. Methods: HER2 negative MBC (HER2-MBC) patients who received chemotherapy (-ies) in our institute from September 2002 to March 2014 were reviewed. Kaplan-Meier method was utilized to estimate median OS and log-rank test was used to compare OS between subgroups. Univariate and multivariate Cox regression analyses were preformed to find significant factor(s) concerning OS. Results: Upon checking our medical record, 446 HER2-MBC patients, median age of 55 (range 25-85) at their diagnosis of MBC were found, and 397 patients were receiving/received chemotherapy (-ies). Disease statuses were as follows; 105 (26.4%) advanced, 292 (73.6%) recurrent, 321 (80.9%) luminal, 76 (19.1%) triple-negative, 149 (37.5%) with visceral disease at MBC diagnosis. Multivariate COX regression analysis disclosed use of eribulin, triple-negative status and liver involvement at the diagnosis of MBC influenced OS significantly. (HR = 2.29; 95% confidence interval [CI] 1.73-3.04; P Conclusions: According to our retrospective, multivariate analyses of house data, eribulin significantly improved OS of HER2-MBC patients. We have to reassess the value of new chemotherapeutic agents continuously. Disclosure: All authors have declared no conflicts of interest.


20 case studies from 18 cities across five continents. These have been developed and selected to inform understanding of the richness and complexity of transcultural placemaking. The book is organised into five parts. The first of these, 'Placemaking at the Margins', explores the sites in which transcultural placemaking typically occurs. Case studies from Chicago, Tokyo, Seattle and Yangon provide examples of how the cultural practices of immigrants and residents find new expression in existing settings. Part II, 'Placemaking in the Space of Flows', focuses on spaces of transition and diaspora through case studies that include Korean migrants in The Philippines, Chinese in Sydney, 'Trans-Asian' migrants in rural Malaysian towns and Africans in Sheffield in the UK, who bring with them multiple knowledge and frames of reference as they adapt to, and adapt, new environments. The third part of the book, 'Bridging Spaces of Difference', examines how cultural differences can be negotiated in placemaking. The case studies focus on the social ties forged among multicultural residents in a public housing complex in Seattle, contestation of territorial claims and place identities in Central Long Beach, California, and the negotiation of racial and ethnic relations among suburban high school students in Fremont, California. Part IV, 'Building Communities across Cultures', focuses on organised efforts to engage communities across cultural barriers, including a case study of efforts to involve immigrant residents in neighbourhood design in Seattle and another that examines community gardens as a site of everyday transcultural learning and community building. Lastly, Part V, 'Struggles for Transcultural Cities', examines barriers and injustices faced by migrants and migrant communities. Case studies here come from Taipei, Hong Kong, Rome and Lancaster, Pennsylvania (the last being an interesting examination of the different physical activity requirements of minority groups in parks in a small town, which concludes that, rather than seeking to create a shared sense of place between the Latino and Anglo communities, the planning and management of parks should 'recognise and respect the rights of both groups and engage in a process of negotiation to accommodate their diverse needs through an engaged parks planning process'). There is only one Australian case study in the collection, Chapter 7, by Duanfang Lu and Hongguang He, entitled 'The Transcultural Production of Space: Making "Little Shanghai" in Sydney'. This investigates the role of Chinese migrants in transforming public spaces in Ashfield, a multicultural suburb in Sydney's inner west which had a mix of 'Anglo', Italian and Greek shops until the mid-1990s but where about 85% of the businesses are now Chinese. It raises both theoretical and policy-related questions about the notion of assimilating migrants into a dominant society, leading to a call for a greater awareness of the knowledge brought by migrants and of how the recognition of a plurality of knowledge can help to build 'a dynamic local community that encourages reciprocity amongst different cultural understandings'. As globalisation proceeds apace in the twentyfirst century, the inevitable growth in transnational migration will lead to increased challenges and opportunities for city planners and others engaged in the regulation and shaping of Australian urban development. This is a lively and timely book which contributes to the greater understanding of migrant experiences and to an awareness of what placemaking processes may involve in an evolving transcultural society. In its paperback version, it is fairly affordable and it is highly recommended by this reviewer.


Automated methods for granular categorization of large corpora of text documents have become increasingly more important with the rate scientific, news, medical, and web documents are growing in the last few years. Automatic keyphrase extraction (AKE) aims to automatically detect a small set of single or multi-words from within a single textual document that captures the main topics of the document. AKE plays an important role in various NLP and information retrieval tasks such as document summarization and categorization, full-text indexing, and article recommendation. Due to the lack of sufficient human-labeled data in different textual contents, supervised learning approaches are not ideal for automatic detection of keyphrases from the content of textual bodies. With the state-of-the-art advances in text embedding techniques, NLP researchers have focused on developing unsupervised methods to obtain meaningful insights from raw datasets. In this work, we introduce Global and Local Embedding Automatic Keyphrase Extractor (GLEAKE) for the task of AKE. GLEAKE utilizes single and multi-word embedding techniques to explore the syntactic and semantic aspects of the candidate phrases and then combines them into a series of embedding-based graphs. Moreover, GLEAKE applies network analysis techniques on each embedding-based graph to refine the most significant phrases as a final set of keyphrases. We demonstrate the high performance of GLEAKE by evaluating its results on five standard AKE datasets from different domains and writing styles and by showing its superiority with regards to other state-of-the-art methods.


An overview of the 28 species of Aradidae found in Michigan is presented, along with an identification key, distribution maps, and relevant literature. Eleven new state records are presented for the following species: Aradus approximatus Parshley, Aradus duzeei Bergroth, Aradus falleni Stål, Aradus insolitus Van Duzee, Aradus intectus Parshley, Aradus montanus Bergroth, Aradus proboscideus Walker, Aradus shermani Heidemann, Aradus uniformis Heidemann, Quilnus niger (Stål) (all Aradinae), and Neuroctenus simplex (Uhler) (Mezirinae).


1. Linear Equations and Matrices 2. Euclidean Space 3. General Vector Spaces 4. Inner Product Spaces 5. Linear Transformation 6. Determinants 7. Eigenvalues and Eigenvectors


To a remarkable extent current science, and the attitudes of current scientists, correspond to an idea conceived by Francis Bacon 400 years ago. Bacon dreamed of using science to subjugate nature for mankind. This is illustrated here by a science-eye's view of bark, a feature of plants particularly apparent in January. But much of the beauty and value of plants is missed by Baconian analysis. The touching story of daphne's metamorphosis into a laurel, her skin becoming bark, shows one such dimension, highlighted in the sculpture by Bernini.


FIELD: transport. SUBSTANCE: invention relates to crane operation safety. In control over crane hook swing, deflection angle and hook rope swing direction are defined in horizontal plane relative to gravity. Note here that deflection angle represents a transverses deflection angle. Deflection angle increase over preset magnitude is recorded. In case deflection angle exceeds preset magnitude, rotary table is turned in direction of swing to measure rotary speed and rotary table angular acceleration and to compare measured values with tolerable standard magnitudes. In case measure magnitudes exceed tolerable magnitudes, both magnitudes are controlled so that these are brought in compliance specifications. EFFECT: higher safety. 8 cl, 6 dwg


Herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) are two highly prevalent, neurotrophic human pathogens. The interplay between HSV and the immune system is important to determine the onset and the outcome of the viral infection, but yet, the precise modulation of the immune system by HSV remains poorly understood. We have previously identi"ed secreted HSV glycoprotein G (SgG) as the "rst viral chemokine binding protein (vCKBP) that, in sharp contrast to all vCKBPs described to date, enhances chemokine function both in vitro and in vivo. Furthermore, we have recently shown the ability of SgG to interact with and modulate the function of neutrophins such as nerve growth factor (NGF), essential elements of the biology of the nervous system.
HSV gG interaction with chemokines induces an enhanced chemotaxis mediated by an augmented receptor signalling and directionality of cell movement. Surface plasmon resonance (SPR) and cell binding assays show that SgG binds to the cell surface through the interaction with glycosaminoglycans. We demonstrate that SgG modulates membrane tra!cking, delays chemokine-mediated internalization, and leads to an increase in the level of chemokine receptors at the cell surface. Moreover, SgG-induced impact on the architecture of the plasma membrane microdomains promotes the incorporation of CXCR4 into lipid rafts and di%erentially alters the fate of other receptors. The link between the aggregation state of chemokine receptors and their functionality has not been characterized. Here, we provide evidences showing that the enhancement of chemokine function is associated with an SgGinduced increase in the presence of CXCR4 small oligomers on the surface, accompanied by conformational rearrangements in CXCR4 homodimers.
SPR-based assays were set up in order to characterize the ability of HSV viral particles to interact with chemokines. Our results demonstrate that HSV virions bind chemokines. The functionality of the virus-chemokine interaction was analyzed in vitro. We show that HSV particles are chemotactic in transwell assays and that they synergize with chemokines to enhance migration. Importantly, we found that envelope-anchored gG has an important contribution to these activities, suggesting the relevance of the HSV gG-chemokine interaction during early stages of the viral infection.


Reducing weight and improving strength of structures have always been major design goals in the aerospace industry since its inception. In particular, strength directly affects the safety and serviceability of an airplane and is therefore of great importance in structural design. Improving the strength of an airframe can effectively increase its damage tolerance in different failure modes, such as fracture, fatigue and impact damage. To pursue these goals, optimization techniques, which aim to seek for the "best solution" in mathematical models, can be applied in the structural design process. In addition, usage of lightweight carbon fiber reinforced composite laminates further serves this purpose....


India is fast developing country and agriculture is the back bone for the countries development in the early stages. Due to industrialization and globalization concepts the field is facing hurdles. On top of that the awareness and the necessity of the cultivation need to be instilled in the minds of the younger generation. Now a day's technology plays vital role in all the fields but till today we are using some old methodologies in agriculture. Identifying plant disease wrongly leads to huge loss of yield, time, money and quality of product. Identifying the condition of plant plays an important role for successful cultivation. Identification of plant disease is very difficult in agriculture field. Leaf disease detection requires huge amount of work, knowledge in the plant diseases, and also require the more processing time. The objective of this research is to make use of significant features and prediction is done using computer vision technique. This method mainly download the image from the server then it converts the image into a gray scale by calculating its pixels and it shows out only the defected parts of the leaf. Generally we can observe the symptoms of disease on leafs, stems, flowers. so here we are using the leafs for identification of disease affected plants. First we need to select the plant which is affected by the disease and then collect the leaf of the plant and take a snapshot of leaf and load the leaf image into the system. It means representation of the image in more meaningful and easy to analyze way. In segmentation, a digital image is partitioned into multiple segments can defined as super-pixels. The main objective of this project is to find out whether the leaf is defected or not. If the leaf is in green color, then there is no defect in the leaf. If the leaf is spotted with black dots then it is shown to be affected by some disease and then we are predicting the disease of leaf and its lifetime is also too low. This approach can significantly support an accurate detection of leaf disease. We can extend this approach by using image processing technique. It displays the output in graphical view that is X and Y coordinates. The user can also view the output in mobile application by retrieving the result from the server.


Chad W. Post is the publisher of Open Letter Books at the University of Rochester, where he also runs the Three Percent website (where he writes weekly posts about translated literature), produces two podcasts, and manages the Translation Database at Publishers Weekly. He's the founder of the Best Translated Book Award and is the author of The Three Percent Problem: Rants and Responses on Publishing, Translation, and the Future of Reading, and the 2018 recipient of the Ottaway Award for the Promotion of International Literature.


Objective To determine the expression of E-cadherin-catenins complex(E-cad,α-cat,β-cat and γ-cat) in early gastric cancer and their relationships with biological characteristics of early gastric cancer by evaluating the invasion and the lymph nodes metastasis of eraly gastric cancer(ECG).Methods 53 cases of EGC,who accepted radical operations from January 1997 to December 2000 in Sir Run Show Hospital were included in this study.According to the invasion depth and lymph nodes metastasis,they were divided into different sub-groups for discussion.Also the normal gastric mucosa of 10 cases with extra-gastric disease were selected as control group.Results All four proteins(E-cad,α-cat,β-cat and γ-cat) were normally expressed in control group.In early gastric cancer,the abnormal expression rates of E-cad,α-cat,β-cat and γ-cat were 64.2%,69.8%,66% and 73.6%,respectively.In the sub-group of mucosal invasion,the abnormal expression rates were 61%(14/23),65.2%(15/23),47.8%(11/23) and 56.5%(13/23),respectively.But in the sub-group of submucosal invasion,the abnormal expression rates were 66.7%(20/30),73.3(22/30)%,80%(24/30) and 86.7%(26/30),respectively.In sub-group of no lymph node metastasis,the abnormal expression rates were 61.4%(27/44),65.9%(29/44),63.6%(28/44) and 70%(31/44) respectively.In sub-group of lymph node metastasis,the abnormal expression rates were 77.8%(7/9),88.9%(8/9),77.8%(7/9) and 88.9%(8/9) respectively.Abnormal expression of β-cat and γ-cat had significantly difference between the sub-group of mucosal invasion and the submucosal invasion(P0.05).Abnormal expression of all four proteins appeared in 7 of 9(77.8%) cases that had lymph nodes metastasis and 7 of 21(33.3%) cases that had no lymph nodes metastasis.There was significantly difference between these two sub-groups(P0.05).Conclusion When early gastric cancer with abnormal expression of β-cat and γ-cat,it may have sub-mucosal invasion.If all the four protein are expressed abnormally in early gastric cancer,it has high possibility with lymph node metastasis.


The paper describes an innovative precast pavement system located on I-57 near Sikeston, MO. Overview of precast pavement technology and associated merits are presented in addition to instrumentation and monitoring plans and preliminary results from the investigation. Early age response and stress transfer measurements are reported. Plans for monitoring in-service performance data are also discussed. Analysis of preliminary results from the investigation, [Dailey 2006, Davis 2006], follow, and include: (a) the early age behavior of the panels during and immediately after fabrication (effects due to hydration and differential thermal stresses during curing), (b) material characteristics such as unrestrained creep and shrinkage, chloride permeability, and freeze thaw resistance, (c) transfer of transverse pre-tensioning, (d) frictional stress losses during post-tensioning operations, and (e) plans for the future monitoring of long-term inservice performance of central anchor panels, base panels, and joint panels.


From 1973 to 1989, 90 cases of obstructing carcinoma of the left colon were treated with five different operative procedures, the Incidence of anastomotic leakage was 6.7%, the operative mortality was 7. 8%. Among all the patients, 14 cases were treated by primary resection with anastomosis. Anastomotic leakage occurred in 6 cases, and 5 of them were died. Of 25 cases with the traditional staged management, the tumors were resected only in 20 cases, and not resectable in the other 5 patients. 19 with modified Hartmann's procedure and 26 with extended right hemlcolectomy with ileorectal or low ileosigmoid anastomosis gave satisfactory results. In terms of this series, the five-year survival rate in primary resection group was significantly higher than that in staged resection group (P< 0. 05). It is suggested that extented right hemlcolectomy or modified Hartmann' s procedure in cases of acute cancerous obstruction of the left colon would be favord.


In 2008 Craft Australia undertook a major redevelopment of the Craft Australia website. Managed by Avi Amesbury, the Craft Australia Communications Manager, we are proud to begin 2009 with the new site and to launch a new direction for the advocacy and promotion of Australian contemporary craft and design through this development.


Comparisons between non-degraded sample of BioPP and samples in water and in sodium water solution 0.9% were made. Variations in thermal characteristics and crystallinity are observed due to material degradation. Several deformations of the degraded curve appear to indicate the melting of several types of crystalline lamellae. Measurements were made on white meshes from BioPP and similar variations as for BioPP for surgical sutures were observed. PGLCL degradation is observed: water, the salt, bacteria and the enzymes from the water acts on the amorphous area and initially destroys this area. This phenomenon leads to the initial increase of crystallinity. At higher degradation stages there are variations of the two maxima of PGLCL, PGA (Polyglycolide) maximum showing a faster decrease.


Electrophoretic and sedimentation analyses were made on the plasma and serum of the hemolymph of the lobster Homarus americanus, and on purified hemocyanin and fibrinogen prepared from these. Amino acid analyses of these two proteins and the plasma, and of the free amino acids of the plasma were also determined. Fibrinogen maintained its function and character upon isolation. It was completely and selectively removed from the plasma by stirring with small amounts of oleic acid. The pH of the hemolymph was 7.6; this was a stable characteristic. The lactic acid in the hemolymph of lobsters held unfed in a disturbing environment at first increased fivefold and then returned to normal; the carbohydrate level remained unchanged.


In recent years,with the change of lifestyle in China, hypertriglyceridemia (HTG) has been the second leading cause of acute pancreatitis (AP). Recent studies have shown that HTG has long-lasting influences on AP onset (including recurrence), AP severity, as well as pancreatic regeneration. However, the underlying mechanisms of HTG-AP is still unclear, mainly focusing on free fatty acid, microcirculation disturbance, calcium overload, oxidative stress, gene polymorphism and so on. However, there is lack of effective intervention for the diagnosis and treatment of HTG-AP, which needs further study.

Key words:
Hypertriglyceridemia; Acute pancreatitis; Research advances


Measurements of transitional flow in regions of strong adverse pressure gradient on an axial compressor stator are reported. The range of observations covers separating laminar flow at transition onset, and reattachment of intermittently turbulent periodically separated shear layers.Transition was characterised by the regular appearance of turbulent spots in association with the rotor blade wake disturbances. However, the initial breakdown did not coincide with the wake passage as has usually been observed by other workers. The spots rather evolved from the growth of instability wave packets which lagged the wake passage.Data presented from the compressor blade measurements include: mean and ensemble-average velocities and associated integral parameters; distributions of total, periodic and random disturbance components; typical individual velocity fluctuation records; contours of ensemble-average random disturbance level; and boundary layer intermittency distributions.Measurements of turbulent intermittency showed a significant fall in this quantity near the wall in the reattaching flow. This has significant implications for the interpretation of transition data from surface film gage observations.Copyright © 1993 by ASME


Advances in genome-based sequencing technologies now allows for numerous genes to be analyzed in a single test, compared with previous gene-by-gene approaches [1]. While genome-based sequencing is gradually integrated into clinical care, there is also a strong push to use these technologies in public health settings [2–4], such as newborn screening programs [2,5]. In line with this interest, the US NIH recently invested US$25 million to study the medical and ethical implications of genomebased sequencing of newborns, although the plethora of issues this might pose are well recognized [6–7]. One issue relates to the paradigm shift in public health programs this use of genomic sequencing would create [6–8]. Since their introduction in the 1960s, the focus of newborn screening programs has been the identification of asymptomatic newborns with rare metabolic disorders, to allow timely interventions that significantly decrease morbidity and mortality. As the best interests of the child (BIC) was the core principle [8], selection of conditions was limited to those where newborns left untreated would suffer from severe illnesses, and early intervention carried definitive medical benefit [9]. In certain regions, the progressive use of new screening technologies has historically led to relaxing of the traditional criteria to screen only for early-onset, treatable conditions [10]. As a result, screening programs have occasionally shifted away from using the BIC as the primary consideration to justify inclusion of conditions in the screening panel. In addition, the nature of the information provided through genome-based newborn screening poses additional hurdles for determining what is within the scope of the BIC at individual, familial and populational levels and the appropriateness of the BIC argument in the newborn screening setting. This article therefore discusses the legal concept of BIC at a theoretical level.


Chapter 1 of Library Technology Reports (vol. 49, no. 1) "Resource Sharing in Libraries: Concepts, Products, Technologies, and Trends" presents some of the conceptual approaches available to libraries in the way that they provide access to materials to their patrons beyond their local collections. Models of resource sharing discussed include sharing an integrated library system among the members of a regional consortium; implementing a resource sharing environment to connect ILS implementations to enable consortial borrowing; and providing materials through document delivery services or global interlibrary loan systems.


Objective To study the therapeutic effect of Xiefuyin enema (XFY)in treating ulcerative colitis.Methods The animal model was established by immunological method plus colon damage.Effect of XFY was observed by gross anatomy and pathological slides for colonic membrane.Results The congestive and edematous colonic membrane in the model an- imals was improved after XFY treatment,and showed a trend of alleviation of disease.Conclusion XFY could effectively improve the colonic membrane congestion and edema,to promote the curing of ulcers.


Malignant melanoma remains a very challenging and unpredictable problem even though it has been the subject of many studies over the years. Efforts to predict its behavior based on sex and age of the patient, site of the primary tumor, microscopic appearance of the malignancy, duration of the pigmented lesion, and history of trauma have been disappointing. The fact that the problem is still encountered and patients must suffer and die, because of the inherent nature of the illness, the unpardonable delay in diagnosis, and the inadequate treatment, warrants reexamination of the subject. The lack of agreement regarding the extent of radical treatment, whether node dissection should be done routinely or whether local excision, node dissection, and removal of the lymphatics in continuity should be followed when the site of the tumor allows this approach to be practical, justifies presentation of a small series in which the treatment method has


The development of small towns in Yunnan has a long history. Its unique characteristics, from ancient times to modern times, are presented as:First, there are various causes for the appearance and flourish of the small towns; Second, the distribution and flourishing of the small towns are unbalanced; Third, the functions and types of the development of small towns are various; Fourth, there is harmonization between the Han nationality and minority nationalities in the transformation of the small towns in Yunnan Province.


We explain that the anomalous frequency shifts of very close masses obtained in the high precision mass measurement experiments in the ESR storage ring result from the locking of Coulomb interacting strings of ions. Here two concentric strings which run horizontally close to each other are captured into a single string if their thermal clouds overlap and give up their identity.


In this paper,binary quadratic Diophantine equation has been studied.The binary quadratic Diophantine equation can be divided into elliptic,hyperbolic,parabolic three.Any indefinite binary quadratic equation can be changed after a linear transformation to a standard form to discuss the use of binary quadratic Diophantine equation of the second specific method,and extended to the case of n-.Solution of the case raises the possibility of leakage,and the feasibility of this method is discussed and improved as well.


Purpose: Ultrarush immunotherapy (ultra-RIT) is more convenient and higher compliant than conventional immunotherapy, but it has rarely used in clinical practice due to severe systemic reactions. This study aimed to determine the safety of ultra-RIT in children and adolescents.
Methods: We investigated 19 patients who received ultra-RIT with the same schedule between January 2011 and May 2016. They were sensitized to house dust mites (HDMs) and/or pollen and had their symptoms associated with positive allergens. Over a 1-day hospitalization period, all patients received ultra-RIT subcutaneously 3 times, increasing at hourly intervals. Systemic reactions were classified according to the World Allergy Organization grade system.
Results: Systemic reactions occurred in 14 patients (73.7%). The mean time to adverse reactions after the last injection was 36 minutes, and the majority of systemic reactions were pruritus and urticaria. In addition, the injection of HDM alone or HDM plus pollen caused more than grade 2 systemic reactions in about 50% each of the patients.
Conclusion: Since ultra-RIT caused a higher incidence of systemic reactions in children and adolescents, it should be carried out cautiously in the hospitalization rather than the office. (Allergy Asthma Respir Dis 2017;5:336-343)


This is a selected list of resources for the FYS course - "We Can, But Should We? Ethical Questions at the Cutting Edge of Scientific Research"


The invention provides an ionic liquid CO2 trapping agent and a preparation method thereof. Due to functional design, the anion is an amino acid radical, and the ionic liquid is synthesized by a halogenated intermediate and is excellent functional ionic liquid; and the product directly serves as the CO2 trapping agent without dehydration and purification. The trapping agent is low in synthesis cost and low in price and has better trapping performance and regeneration performance than amino salt absorbents. The invention can be applied to tower reactors (such as bubble towers, packed towers, plate towers and the like) and the film absorption process; the trapping agent is recycled in a device; and the provided ionic liquid has wide application market in the field of separating and trapping of acid gases.


This government-bashing book deplores the lack of safety in the mining of uranium ore and selected other events. The author uses a broad brush to condemn the Atomic Energy Commission (AEC) and the US Public Health Service (USPHS) for abuse of discretionary authority in pursuing a risky national security policy involving a "pact with the devil." This "pact" was allegedly a conspiracy of silence from 1945 to 1978, which resulted in the deaths of hundreds of uranium miners from lung cancer. The author cites alleged injuries in several other cases, such as mock germ warfare tests over cities, the Tuskegee syphilis experiment, and a number of radiation experiments, which he attributes to similar abuses. The book includes no interviews with persons directly involved in the pact. Knowledge of their motives and attitudes would be important. The four main points on which the book's thesis rests are (1) most radiation scientists


From the learning characteristics,the article analysis the positive and negative effects of the internet environment on college students'learning psychology,and proposed the effective measures on correct learning psychology under the internet environment.


Based on combined uncertainty and bathymetry estimator (CUBE) algorithm, a dynamic linear model (DLM) including horizontal and vertical soundings data uncertainties is discussed. Kalman filtering and multiple estimations are utilized to calculate the grid nodes. According to the real measured data of survey area of Bohai, comparison with the manual interactive process, CUBE algorithm is presented to estimate the true depth of the grid points of the survey area in this paper. From the experimental results, it can be seen that the CUBE algorithm is efficient and has good robustness, which means the proposed algorithm is suitable for massive multibeam soundings data in real-time automatic processing.


Abstract In this article, accumulated sudden infant death syndrome (SIDS) data, from 1974–1978 and 1979–1984 for the counties of North Carolina, are analyzed. After a spatial exploratory data analysis, Markov random-field models are fit to the data. The (spatial) trend is meant to capture the large-scale variation in the data, and the variance and spatial dependence are meant to capture the small-scale variation. The trend could be a function of other explanatory variables or could simply be modeled as a function of spatial location. Both models are fit and compared. The results give an excellent illustration of a phenomenon already well-known in time series, that autocorrelation in data can be due to an undiscovered explanatory variable. Indeed, for 1974–1978 we confirm a dependence of SIDS rate on proportion of nonwhite babies born, along with insignificant spatial correlation. Without this regressor variable, however, the spatial correlation is significant. In 1979–1984, perhaps due to reporting bias o...


We discuss the general form of the mass terms that can appear in the effective field theories of coordinate-dependent compactifications a la Scherk-Schwarz. As an illustrative example, we consider an interacting five-dimensional theory compactified on the orbifold S^1/Z_2, with a fermion subject to twisted periodicity conditions. We show how the same physics can be described by equivalent effective Lagrangians for periodic fields, related by field redefinitions and differing only in the form of the five-dimensional mass terms. In a suitable limit, these mass terms can be localized at the orbifold fixed points. We also show how to reconstruct the twist parameter from any given mass terms of the allowed form. Finally, after mentioning some possible generalizations of our results, we re-discuss the example of brane-induced supersymmetry breaking in five-dimensional Poincare' supergravity, and comment on its relation with gaugino condensation in M-theory.


This paper describes the design of a type system for the Larch/C++ speci cation language. To motivate the features of the type system, the type systems of both the Larch Shared Language and C++ are described. After this background, an informal description of the Larch/C++ type system is followed by a formal presentation of the type rules. The implementation of an infrastructure for the type system is then described.


An ironic feature of contemporary South African politics is that while the organisations representing Black Consciousness (BC) ideas remain weak and fragmented, a revival in BC ideas, values and practices in official and civil society discourses seems evident. BC organisations dominated anti-apartheid politics in the 1970s, but their startling decline, particularly their weakened state under post-1994 democracy, calls out for analytical attention. In the 1999 and 2004 elections, the Azanian People's Organisation (Azapo) was the leading BC organisation. Together with the smaller Socialist Party of Azania (Sopa), Azapo received dismal support. Moreover, Azapo has split into three smaller organisations. Efforts to merge the three have so far faltered. One cannot conclude, however, that the obvious failure of BC political parties to challenge the ANC and the historically white political parties at the polls means that we should dismiss these organisations' ideologies as ineffective and lacking in influence. The resurgence of BC ideas at the level of civil society, at a time when we might expect BC to be anachronistic, is intriguing. It is also the subject of this chapter.


Once the Cartesian dualism had been overcome, the man discovered himself as an object in an objective world, as well as the subject of all his possibilities, and psychiatrists have to face with this reality. Understanding such a premise, it is possible to explain the crisis of a science that, instead of dealing with people with mental disorders in the society in which they live, has gradually constructed an ideal image of man, in order to guarantee the scientific validity of the castle of disease, which imprisoned the symptoms. Traditional psychiatry has limited itself to define the syndromes for labelling the patient, ripped from his environment and alienated from the social context, and 'forced' to adhere to an illness that is an abstract, symbolic, and, as such, ideological disease. However, objectification of man into a syndrome has had irreversible consequences for the mentally ill; patients were originally objectified and restricted within the borders of their illness, and science has confirmed that this category is outside what is human, since there is the need to exclude what it is not understandable. However, a scientific approach—regardless to the specific topic—searches for causes of a phenomenon isolated from the superstructures and ideologies. In the case of mental disorders, if the intention is to tackle it scientifically, the first step must be to 'set aside' the disorder and the way it has been classified, in order to consider the patient's behaviour, which seems to be approachable. Taking this background into account, the aim of the present paper is to analyse the problem of patients with mental disorders according to a way of being that is the same as healthy people, beyond every pattern and definition of disorder. The pattern of excluding and be excluded—if these can be part of human relationships—represents the basis of psychotic experience—as exclusion from reality—as well as of patients with mental disorders, excluded from the society. Every society whose structures are based only on cultural, social-classes differentiations and on competitive systems creates its compensation areas for its own internal contradictions, where it gives a concrete form to the need to deny or to fix and to objectify a part of its own subjectivity. Searching for a patsy (or scapegoat), for someone to exclude and on which to focus aggressiveness, can only be explained by man's desire to delineate and exclude his own fears. Racism—in all its forms—represents this need for compensation areas. The asylums, as a symbol of 'psychiatric sanctuary', such as the apartheid against blacks or Jews, represents the desire to exclude the unknown and the inaccessible which frightens the society. Psychiatry—as a discipline—has justified and scientifically confirmed this desire, considering the studied object as incomprehensible, and listing it among the categories to be excluded. The human being—faced with own fears and with the need to assume his responsibilities—identifies in others the part not able to dominate, and to exclude the other in himself as his contingency. This represents a way of denying it in himself by denying the other, leaving and excluding the groups in which these fears have been identified. Discriminating behaviours and social exclusion—having the right to socially exclude from society a group representing all


Objective To study the relevant technology of the quality stability of qingxintongmai granules.Methods According to Approval Method of New Drugs on the requirement of sample stability investigation and quality standard draft,the stability of the drug was observed.Results The alcoholic extraction rate of salvia miltiorrhiza and ginseng was stable in technology and good in reproducibility.The decocting extraction of five herbal materials,such as radix astragali was stable in technology and good in reproducibility.Conclusion Xiangxintongmai granules are good in quality stability and meet every regulation of drug quality standard draft.


In order to develop a water-saving irrigation system for spring wheat, field experiments were conducted on the deficit irrigation of spring wheat in Hetao Irrigation District, Inner Mongolia. Through measurement of soil moisture content, the spring wheat growth and yield index, the influences of deficit irrigation on soil moisture distribution and spring wheat growth were studied. Results showed that, in the soil layers 0–100 cm below the ground, the soil moisture content under full irrigation at 100% ETc (ETc denotes actual water demanded by crops) and that under deficit irrigation at 80% ETc increased with the increase of soil layer depth; specifically, soil moisture under deficit irrigation at 60% ETc was mainly distributed in the subsurface layer (20–40 cm) and the middle layer (40–60 cm). The spring wheat yield was not greatly influenced by the deficit irrigation at 80% ETc, showing a decrease of merely 5–13% compared with that under full irrigation, while deficit irrigation at 60% ETc had greater impact on the growth and yield of spring wheat, cutting the yield by 10–37% in comparison with that under full irrigation. In the study area, the deficit irrigation treatment at 80% ETc was adopted, wherein the irrigation norm in the growth period was 288 mm. This irrigation system had little adverse impact on spring wheat growth and yield, and therefore, watersaving irrigation could be realized.


The economic and trade relations between Guangxi and ASEAN are characterized as follows: petty trade in the border creas is one of the main modes;the trade is composed of both competitiveness and complementarities;trade dependency is very high between Guangxi and Vietnam.The establishment of CAFTA has not only enhanced the bilateral trade and investment,but also increased the GDP of Guangxi and the development of relevant industries.Both parties should make the most use of the platform of China-ASEAN Exposition to promote the development of service trade,to adjust the export structure of agricultural products,to optimize all-round cooperation with every country and to strengthen infrastructure construction.


Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease of small vessel caused by mutations in the NOTCH3 gene (NCBI Gene ID: 4854) located on chromosome 19p13.1. NOTCH3 consists of 33 exons which encode a protein of 2321 amino acids. Exons 3 and 4 were found to be mutation hotspots, containing more than 65% of all CADASIL mutations. We performed direct sequencing on an ABI 3130 Genetic Analyser to screen for mutations and polymorphisms on 300 patients who were clinically suspected to have CADASIL. First, exons 3 and 4 were screened in NOTCH3 and if there were no variations found, then extended CADASIL testing (exons 2, 11, 18 and 19) was offered to patients. Here we report two novel non-synonymous mutations identified in the NOTCH3 gene. The first mutation, located in exon 4 was found in a 49 year-old female and causes an alanine to valine amino acid change at position 202 (590C>T). The second mutation, located in exon 11, was found in a 66 year-old female and causes a cysteine to arginine amino acid change at position 579 (1735T>C). We also report a 46 year-old male with a known polymorphism Thr101Thr (rs3815188) and an unreported polymorphism NM_000435.2:c.680+60A>G observed in intron 4 of the NOTCH3 gene. Although Ala202Ala (rs1043994) is a common polymorphism in the NOTCH3 gene, our reported novel mutation (Ala202Val) causes an amino acid change at the same locus. Our other reported mutation (Cys579Arg) correlates well with other known mutations in NOTCH3, as the majority of the CADASIL-associated mutations in NOTCH3 generally occur in the EGF-like (epidermal growth factorlike) repeat domain, causing a change in the number of cysteine residues. The intronic polymorphism NM_000435.2:c.680+60A>G lies close to the intron-exon boundary and may affect the splicing mechanism in the NOTCH3 gene. Abbreviations: NOTCH3 (Notch homolog 3 (Drosophila)); CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy); EGF (epidermal growth factor); MRI (magnetic resonance imaging); GOM (granular osmiophilic material)


A model recently introduced by Jaffe and Wilczek based on the quarks being dynamically bound into diquarks has been used to predict that the recently observed exotic baryons (pentaquarks) fall into a nearly ideally mixed combination of an octer and anti-decuplet representations of SU(3) flavor. The model predicts two states with nucleon quantum numbers which have tentatively been identified with the N*(1440) and the N*(1710). This paper examines the viability of this model by focusing on the decay width of the nucleon members of the multiplet. An inequality relating the partial widths of these nucleon states in the N+nucleon channel to the width of the theta+ is derived for this model under the assuming ideal mixing and that the only significant exact SU(3) symmetry violations are the result of ideal mixing, threshold effects and the masses of pseudo-Goldstone bosons. This inequality is badly violated if the states in the multiplet are the N*(1440) and the N*(1710) and if the recent bounds extracted for the theta+ width are reliable. Thus, the model appears to require a scenario with the existence of at least one presently unknown resonance with nucleon quantum numbers.


Between 1977 and 1986, 201 patients underwent replantations at the Accident Hospital in Salzburg. Of these 201 cases, 112 (55.7%) were work-related accidents. The first 47 cases were evaluated by two independent experts, comparing the actual occupational disability, i.e. impairment of earning capacity after replantation with the probable occupational disability payment had the replantation not been performed. In thirty-nine out of forty-seven cases, replantation had led to lower disability benefits.


Dermatology, starting as a separate field of medical science, may be said to be scarcely more than half a century old. Initially, its teaching was based on a series of morphologic pictures, which differed in minutiae. Its development along these morphologic lines has resulted in a ponderous nomenclature to which are constantly being added new diseases and new names. Acknowledging freely our deep obligation to our predecessors and teachers, to whom for the establishment of dermatology as a separate field of medicine we owe an everlasting debt, it is only fair to say that as a specialty based purely on morphology, dermatology could not have developed and taken its right place in the field of modern medicine. Its setting up as a separate specialty not only achieved this commendable result but also made for a lamentable cleavage from other fields of general medicine, with which it is indissolubly bound. Not


Backgrounds: Patients with underlying comorbidities are more prone to contracting COVID-19 and developing severe and clinically deteriorating disease than patients without previous comorbidities. Obesity is a comorbid disease of COVID-19 with a high prevalence and is associated with the severity of COVID-19. This study aims to know about obesity as a risk factor of COVID-19 Severity. Methods/Design: This research method is literature review. The data bases used include Pubmed, DOAJ, and Wiley in the period 2016 until 2020. The keywords used in this article search is obesity, severity, and Covid-19. Based on the keywords used, 3,271 related articles were obtained. Based on the results of the article search process from various databases, 10 relevant articles were obtained. Conclusion: From the systematic review study obtained, it shows that obesity is a risk factor of COVID-19 severity.


This study aims to determine how much influence the Engagement of learning mathematics has on the mathematics learning achievement of students at SMA Negeri 22 Gowa Regency. The research method used is ex-post facto quantitative research which is causal. The population in this study were students of class XI SMA Negeri 22 Gowa with a total sample of 207 students. Data collection was carried out using instruments in the form of a learning engagement scale and report cards for the 2020/2021 academic year in mathematics. The data analysis technique used in this study is inferential statistics using simple regression analysis with prerequisite tests including normality tests, linearity tests. Based on the results of the study, it shows that there is a positive and significant influence between the Engagement of learning mathematics and learning achievement of students in SMA Negeri 22 Gowa Regency. This is proven by the value of t count = 4.113 with t table = 0.6757 and sig = 0.000 < = 0.05. It can be concluded that there is a positive and significant effect of Engagement learning mathematics on mathematics learning achievement. The magnitude of the influence of mathematics learning Engagement on mathematics learning achievement is 7.62%.


Now it has been established that target organ damage (heart, kidneys, brain) is of high importance in determining cardiovascular risk in hypertensive patients. Taking it into consideration we use echocardiography to reveal the evidence of heart involvement in young patients with hypertension. Our data point to the importance of echocardiographic examination, particularly in young hypertonic patients in whom heart damage is not always discovered by routine investigations.


An object oriented programming(OOP) framework is presented to solve plane elastostatic contact problems by means of the boundary element method(BEM). Unified modeling language(UML) is chosen to describe the structure of the program without loss of generality, even though all implemented codes are written with C++. The implementation is based on computational abstractions of both mathematical and physical concepts associated with contact mechanics involving geometrical nonlinearities and the corner node problems for multi-valued traction. The overall class organization for contact analysis is discussed in detail. Numerical examples are also presented to verify the accuracy of the developed BEM program.


Abstract Latin deponents are usually treated as morphological idiosyncrasies in which the Middle morphology is not related to an anticausative (change of state), reflexive or passive syntactic structure, in which it would be expected and grammatically justified (Embick, David. 2000. Features syntax and categories in the Latin perfect. Linguistic Inquiry 31(2). 185–230; Xu, Zheng, Mark Aronoff and Frank Anshen. 2007. Deponency in Latin. In Matthew Baerman et al. (eds.), Deponency and morphological mismatches, 127–144. Oxford: Oxford University Press). Focusing on the non-denominal deponents, I show that these verbs are always reflexives or anticausatives. In the reflexive and anticausative structures a single argument gains two thematic roles, the most external one, doer for the reflexives, undergoer for the anticausatives, and a lower one (holder of a state, benefactive, etc.). The Latin Middle morphology marks the external role as syntactically deactivated but semantically existential and allows for the assignment of the external role to a lower argument. The peculiarity of deponents is not the presence of the Middle, but the fact that, because of specific lexical constraints, these verbs cannot be present in an Active derivation. Similar lexically constrained verbs which can only appear in anticausative or reflexive structures are crosslinguistically attested: deponents are not Latin idiosyncrasies.


Application of insecticide is the most common method to reduce the housefly population. However, in general, not all individual received lethal dose of insecticide. This condition could produce a favorable biological responses, such as increasing the reproductive ability, known as hormesis. This study was carried out to observe the effect of application of sublethal concentrations (LC50) or dosage (LD50) of imidacloprid and permethrin to reproductive ability of resistant strains of house fly. The responses were assessed for 10 generations to simulate the long term effect. The results showed that house flies received application of LD5 of permethrin increased their fecundity (17.05% more than application of LD15 and 56.39% more than control) and the fertility (26.73% more than application of LD15 and 63.62% more than control). On the other hand, application of LC5 of much imidacloprid also increased fecundity of housefly (10.46% more than application LC15 and 45.91% more than control) and the fertility (17.08% more than application LC15 and 49.17% more than control). It could be concluded that administration of sublethal doses of permethrin and much newer imidacloprid may induce reproductive hormesis in the housefly through increasing fecundity and fertility.


Intercropping system of maize and cassava has been practiced widely by Indonesian farmer on dry land. Competition between the plant will happen in the system. Field experiment to understand about the competition has been conducted.   Field experiment of growing maize (Arjuna, Pioneer 4, and Cargill 9 in various planting densities) and cassava (Adira 1) was conducted for monoculture and intercropped plants.  Intercropped cassava increased intraspesific competition of maize.  Yield of maize variety of Arjuna, Pioner 4, and Cargill 9 decreased by about 9.7%, 6.7%, and 16.9% respectively. Maize also reduced growth and yield of cassava. When intercropped with Arjuna, pioner 4, and Cargill 9 at the highest density (80 000 plants ha- 1 ), yield of cassava tuber decreased by about 40.6%, 43% and 64.3%, respectively. However, the intercropping still gave a better land productivity, where land equivalent ratio (LER) was larger than 1.0.  Key words: intercropping, competition, maize, cassava


The world's most innovative, imaginative works in computer graphics and interactive techniques: animation, visualization, simulation, visual effects, and technical imagery produced by adventurers who blend art and science into unique visual experiences.


Authors Julia M. Wondolleck and Steven L. Yaffee have published several books and articles on ecosystem-based management (EBM) and are experts on this topic in landbased applications. Their past research provides evidence that EBM will achieve superior results for long-term ecosystem health over confrontational approaches that rely on regulatory authority. Complex relationships within natural and social systems require collaboration over large spatial scales in order to avoid conflicts between regulators and the people who live in the ecosystems and rely on them for their livelihoods. In Marine EcosystemBased Management in Practice; Different Pathways, Common Lessons, these researchers study EBM as it is being applied to marine environments. In this book, they present detailed case studies and identify common lessons learned that can be translated into success for other EBM approaches, terrestrial or marine-based.


In the short decades since the introduction of positive psychology instigated broader interdisciplinary research, interest in happiness has been growing in academia, the media and public policy. Numerous critiques of these developments have been forwarded from a variety of theoretical and disciplinary traditions. This article discusses three such criticisms: the culture-bound and normative character of happiness, 'bad science' and scientism, and diminished subjectivity and individualisation. It is argued that criticism, particularly internal criticism, evidences the maturity of the field. However, the depth of some critiques may also indicate that interest in happiness is bound with broader cultural preoccupations and is likely to be superseded.


Background:Retakes of intra oral radiographs happen frequently in dental practice although radiographic courses train dental students in consecutive semesters. To reduce the patient's exposure as much as possible it is mandatory to reduce the number of retakes both in radiology clinics and educational centers. In order to reduce the patient exposure as much as possible. Materials and Methods: 3188 periapical radiographs taken by bisect-angle technique were evaluated in this cross-sectional study to assess the frequent errors necessitating retakes. Views were taken by fourth year dental students using bisect angle method. Errors were tabled according to site and type.Results: The four major errors that were found in the study included incor


Abstract Migration and colonization patterns of neural crest cells were analyzed histochemically in embryos of the brook lamprey, Lampetra reissneri, and the swordtail, Xiphophorus helleri, using HNK-1 monoclonal antibody, which recognizes migratory neural crest cells and crest derivatives in many groups of vertebrates including teleosts. We demonstrated that HNK-1 recognizes a subpopulation of naural crest cells and crest derivatives in the lamprey as well as in the swordtail. In the trunk of lamprey and swordtail embryos, HNK-1-positive cells were observed in the major migratory pathways of neural crest cells, that is ventral and dorso-lateral pathways. In the swordtail embryos, neural crest cells in the ventral pathway were ubiquitously observed along the rostro-caudal axis at the neural tube level, but at the notochord level their migration was restricted to the middle region of the somite. In the lamprey, by contrast, no HNK-1-immunoreactive neural crest cells migrated ventrally beyond the notochord level in the ventral pathway at axial levels behind the gill pouch region. This migration pattern of neural crest cells in the lamprey trunk might be closely related to the absence of anatomically distinct, sympathetic chains in the lamprey, which is one of characteristic features of the lamprey's body organization. Furthermore, we found dorsal pathways, which extended to the embryonic dorsal fin, of neural crest cells in both swordtail and lamprey embryos. In the lamprey, dorsal cells (Rohon-Beard cells) and cells that resemble chromaffin cells immunoreacted with HNK-1.


A combination of multiple trichoepithelioma and basal cell epithelioma is reported. Although malignant degeneration of trichoepithelioma is debated, clinical and histopathological studies, in our case, hint at that. The case is reported for its rarity.


Objective: Australia is the only developed country in the world that still has endemic levels of blinding trachoma. The SAFE (Surgery, Antibiotics, Facial cleanliness, Environmental improvement) strategy is an effective public health intervention that has been successfully used to eliminate blinding trachoma in some of the poorest countries of the world. Yet the SAFE strategy has not been systematically implemented in Australia. We undertook semi-structured interviews to identify some of barriers to the implementation of the SAFE strategy within remote indigenous communities of Australia. Methods: Health care professionals who were responsible for delivering trachoma control programs throughout the Northern Territory were asked to participate in a semi-structured interview. Quantitative analysis was performed using an existing strategic management framework. Results: Fourteen individuals were interviewed. Responses were grouped into 19 categories; 12 from the existing strategic management framework and 7 additional categories that were created for ideas unique to the trachoma control program in Australia. Conclusions: A number of key themes emerged from the interview and are presented in a literary style. From these key themes critical success factors for the implementation of a sustainable trachoma control program were identified. With the election of the Rudd government there has been a renewed interest in "closing the gap" between the health of indigenous and non-indigenous Australians. A federal government funding package of $58 million over four years has just been announced to tackle trachoma. It is hoped that the findings of this research can assist in making sure that money achieves its goal.


An annular combustion chamber has an inner wall (10) and an outer wall (20) of composite material having a ceramic matrix and a chamber bottom (30) connected to the inner and outer walls. Connecting elements (17, 27) deformable elastically connect the inner and outer walls of the chamber to the inner and outer metal housings. Each of the inner walls (10) and outer (20) of the chamber is circumferentially divided into sectors (100, 200) along adjacent longitudinal edges, each sector being folded outwardly of the chamber at each of its edges longitudinal to form a U-section portion terminating in a return (102, 202) spaced from the outer face of the wall of each chamber, and the connecting elements (17, 27) are connected to inner and outer walls of the room by fixing on returns areas.


Japan's public pension system underwent radical reforms in 2004, and the results of the first financial review under the new regime were released in February 2009. Although the review concluded that systemic revisions were unnecessary, some observers have criticized the report for its use of overly optimistic assumptions. In addition, there has been a rekindling of the debate over whether the basic pension should be funded by premiums or by taxes. If demographics and socio-economic conditions necessitate further reforms, it is essential that those reforms be started without delay.


One of the innovations of the Federal Law "On Education in the Russian Federation" is a network form of educational programs. Using the network form can meet the challenges of vertical and horizontal integration of participants in the educational process. The article deals with legal support network form educational programs, its objectives and tasks, reveals the concept of this new method of education.


Civil engineering informatics treats technologies, methodologies, models and processes for the application of information systems in civil engineering. The basic technology is provided by computer science and computer industry. It comprises operating systems for computers and networks, programming platforms, standard application tools, and standard communication tools. The methodologies, models and the processes as well as the advanced software technologies are to a large extent specific to civil engineering informatics. This paper starts with an overview on general applications of IT in civil engineering and follows with some more specific application in building industry such as: virtual buildings, CAD systems and collaborative design. IT proves to be beneficial for it has the potential to enhance project communication and eliminate sources of expensive errors and conflicts, resulting in efficiency and productivity. However, the building industry has been reluctant to adopt the technology. This paper seeks to stake out the reasons that hinder the adaptation of this technology in Iran and thereby suggests the methodology leading to a localized solution.


The secondary skin malignancies arising in seborrheic keratosis (SK) are uncommon, and the causal association between the pre‐existing lesion and subsequent malignant transformation remains uncertain. Among these enigmatic conditions, trichilemmal differentiation and/or neoplasms in SK have rarely been reported thus far. Herein, we describe a case of invasive trichilemmal carcinoma arising in a long‐standing SK of the abdominal skin, and clinicopathologically review this rare complication with a computerized medical published work search (PubMed) and citations from earlier reports. To our knowledge, only four cases of trichilemmal tumors arising in SK have been observed, and, interestingly, all cases, including ours, were Japanese. Four of five cases (80%) developed the tumors in non‐sun‐exposed SK, and indeed had no apparent actinic damage in the histology. The pre‐existing SK itself is more likely to act as the primary pathogenic event for developing the secondary trichilemmal tumors than a coincidental phenomenon and a consequence of skin damage by cumulative sun exposure.


Anger is often a weapon for all creatures to defend their lives through the most natural way or mechanism, namely attacking other animals who are bullies or threats, not even a teacher, also has an angry agent like other living creatures. This study aims to examine anger management to manage anger for PAUD teachers to conduct the learning process calmly, not depressed, and not stressful for children. This research uses qualitative methods of this type of case study with a purposive sampling approach conducted at the Raudhatul Athfal Nurul Islam Kalibuntu Probolinggo institute. The informants in the study were principals, group A teachers, and group B teachers. Results from anger management research in improving teacher performance in schools show that first, analyze the causes of the problem. Second, personal approach and place oriented. Third, reflection so that every teacher knows the extent of their ability to manage anger. The implication is that teachers should remind each other in controlling emotions, especially when in the school environment.


Abstract : This document describes a signal processor for remote optical interferometric sensors which provides detection of signals by means of optical fibers from the sensors without the need for feedback stabilization of below signal band low frequency fluctuations and drift. Amplitude as well as phase stability is maintained. Although feedback techniques are not necessary, use of feedback for the signal band provides linearity of output and suppression of noise thus permitting stable operation of multiple sensor channels using only a single laser source. (Author)


A BEER-based measure of the Korean Won/dollar is estimated using the cointegration methods of Johansen(1995). Impulse response analysis shows that the responses of the real exchange rate to the various shocks differ. Variance decomposition anylysis demonstrates that the net foreign asset and productivity differential plays a important role in explaining the behavior of real exchange cointegrating equation reveals the periods of overvaluation in the 1990s until the 1997 financial crisis.


Tight packing between structural elements is a prerequisite for molecular recognition and catalysis. In proteins, α-helices and β-sheets present the amino acid side chains on the surface while the polar amide bonds are buried. The opposite is found in double- and polystranded nucleic acids, where negatively charged phosphates occupy the surface and the side chains are hydrogen bonded in the core. Thus the question arises: How do densely packed nucleic acid molecules achieve close approach, despite the repulsion between phosphates that would appear to preclude tight contacts? One obvious answer is by mediating interstrand contacts through coordinated cations that can screen the negative charges. In this contribution, however, we highlight a variety of alternative direct interactions involving atoms of the sugar-phosphate backbone that can promote tight packing of RNA and DNA into functional molecules. We have analyzed the existing nucleic acid crystal structures in terms of the presence of close contacts between backbone regions. In RNA, ribose 2′-hydroxyl groups were observed to mediate such contacts in the majority of cases. However, their absence in DNA does not prevent oligodeoxynucleotides from packing tightly, aided by various interactions between backbone atoms.


This research explores the effects of coronavirus on global relations and strategy making in the international arena. Coronavirus or Covid-19 is a newly discovered virus in the world examined dynamically at the existing world. The indisposition of the virus might retain up enhancing the opinion of the spread of the contagion rate and the absence of a suitable vaccine (Lipsitch, Swerdlow, & Finelli, 2020). Covid-19 was initially testified from Wuhan, China, and formerly on it directed to a dynamic spread leading it to convert as a worldwide pandemic which led to a consequential international situation which has obstructed many subdivisions Internationally, including Worldwide Policies, Systematic signs of progress, Financial Effects over the several nations and worldwide relations between the countries. Thus, this paper tries to determine the potential effects and consequences of the Covid-19 pandemic over the global level and few conceivable ways to be controlled efficiently.


PURPOSE: A vibration damper and a manufacturing method thereof are provided to effectively control vibration by minutely adjusting a damper according to changes in natural frequency. CONSTITUTION: A vibration damper capable of fine adjustment comprises a damper part(20), limiter members(18), and a vibrator(10). The damper part comprises a first cylinder, a second cylinder, a piston, and a control unit. The limiter members are provided on one side of the damper part. The vibrator is provided between the damper part and the limiter members and is connected to the damper part via a piston rod(15) to be actuated by an external impact.


Objective To monitor and analyze aquatic products in order to realize hygienic condition of aquatic products in Guangzhou city.Method 229 samples of aquatic products including shrimp,crab,fish,and shell were stochastically collected from 2 supermarkets,10 fairs and 31 restaurants in Guangzhou city from March to November in 2006.Hygienics evaluation was made,based on the results of testing items including antibiotics,heavy metal,formaldehyde,clonorchis sinensis,vibrio parahaemolyticus,et al.Results The over-standard rates of residual contents of terramycin and acheomycin were higher.The total qualified rates of terramycin and acheomycin in 96 samples were 57.3% and 80.2%,respectively,and only 35.0% of crustacean(shrimp crab) samples reached the normal level of terramycin.Chloramphenocol that was forbidden as veterinary drug in China was detected in one fresh crustacean sample.The qualified rates of antibiotics residue in March and April were more than those in September and October.Formaldehyde in 69.5% of 59 samples was up to the national standards,and the highest value of formaldehydes reached 852 mg/kg,far beyond the upper limit of standards.11.5% clonorchis sinensis and 22.5% vibrio parahaemolyticus were detected in fresh aquatic products.Conclusion The high residue of antibiotics in aquatic products directly related to the misusing of antibiotics during high-incidence season for aquatic diseases.The results also revealed that formaldehyde was abusively used in aquatic products,especially in waterishlogged aquatic products.The detection rates of clonorchis sinensis and vibrio parahaemolyticus were much higher,so it was indicated there was high risk to eat raw or underdone fish and shrimp.For health and safety of consumers,the hygienic inspection and guidance throughout the processes of breeding,sales and consumption of aquatic products shoved be enhanced.


A SI derived unit used for linear electric current density, magnetic field strength, and magnetization. It is the magnetic auxiliary field strength created tangentially at a distance of one meter from a straight conductor of infinite length and with negligible cross section by a circulating current of one ampere, or linear electric current density when one ampere electric current is conducted in one meter wide conducting sheet.


Membranes made from silicon nitride have significantly higher mechanical Q-factors under tensile stress than those made of other dielectric materials. This makes them ideal candidates for membrane reflectors that provide high finesse in Fabry-Perot cavities or membrane-in-the-middle optomechanical systems. Building on our previous work with one-dimensional gratings on suspended membranes, we patterned two-dimensional photonic crystal gratings on monolithic, suspended membranes made from silicon nitride. These high-Q membranes exhibited high reflectivity, upwards of 99%, over several nanometers in the telecom band. To probe their optical response in a cavity environment, we used these membrane reflectors as the moving mirror in a Fabry-Perot cavity. We were able to realize cavities with a finesse of over 4,500.


In this study we investigate the drivers of corporate social performance (CSP) and focus on the role of corporate executives and how they contribute to CSP given their distinct organizational and institutional environments. Drawing on strategic leadership and upper echelon theory as well as frameworks that conceptualize the embeddedness of individuals in their social contexts we argue that organizational outcomes related to corporate social responsibility (CSR) are generally a reflection of their corporate executives, however, how they affect CSP is contingent on the interplay of a range of context factors. By adopting a multi-level perspective and using fuzzy-set qualitative comparative analysis on a sample of 81 leading Fortune 200 MNEs from the US we explore how individual, organizational and institutional level factors concur in yielding high levels of CSP in different dimensions. We find that corporate executives and context factors matter, yet, that different causal paths explain how the combination...


A two-stage, minimal model of eggshell growth is proposed. In a first stage growth is on isolated columns by aggregation on elliptical nucleation sites, the mammillae. It is controlled by a single parameter, the growth velocity. In a second stage, columns touch and the surface growth as a whole with a second parameter, surface relaxation. A differential equation that incorporates tehse features is numerically solved for various values of said parameters, in one space and one time dimension. Level curves are presented for various values of the parameters, indicating the dependence of column and pore geometry on them.


In this article the authors provide practitioners and researchers with three illustrations of how to use systematic screening tools within the context of three-tiered models of support to (a) measure the overall level of risk present in a school over time and (b) identify students who may require more targeted supports in the form of secondary and tertiary prevention efforts. Specifically, the authors explore data-driven approaches to interpreting systematic screening data collected as part of regular school practices at the high, middle, and elementary school levels. In each illustration they describe the student population, the procedures used by each school to construct the three-tiered model, the primary prevention plan developed, the systematic screening tool incorporated into regular school practices, and the data analysis plan. Furthermore, the authors offer findings of treatment outcome studies that demonstrate how student risk shifts over time following program implementation. They also include hypothetical and actual illustrations of how to use data from a variety of screening tools to identify students for secondary and tertiary prevention efforts.


The V/Vmax test is applied to gamma-ray bursts of duration longer than 1 sec recorded by the Konus experiment, to examine quantitatively the uniformity of the burst source population. A sample of 123 bursts detected on Venera 11 and Venera 12, gives mean V/Vmax = 0.45 + or - 0.03, consistent with 0.5, the value expected for a uniform distribution in space of the parent population of burst sources. It is argued that experimenters give careful attention to the detection limit for each recorded gamma-ray burst, and that quantitative data for burst properties and detection limits should be published. 28 refs.


The Congenital Dyserythropoietic Anemias (CDA) are rare hereditary hemolytic disorders with large bi- to multi-nucleated erythroblasts in the bone marrow. Hemolysis is negative in a direct antiglob ...


Small animals typically localize sound sources by means of complex internal connections and baffles that effectively increase time or intensity differences between the 2 ears. But some miniature acoustic species achieve directional hearing without such devices, indicating that other mechanisms have evolved. Using 3D laser vi- brometry to measure tympanum deflection, we show that female lesser waxmoths ( Achroia grisella ) can orient toward the 100-kHz male song because each ear functions independently as an asymmetric pressure gradient receiver that responds sharply to high- frequency sound arriving from an azimuth angle 30 ° contralateral to the animal's midline. We found that females presented with a song stimulus while running on a locomotion compensation sphere follow a trajectory 20 ° - 40 ° to the left or right of the stimulus heading but not directly toward it, movement consistent with the tympanum deflections and suggestive of a monaural mechanism of auditory tracking. Moreover, females losing their track typically regain it by auditory scanning (cid:3238) sudden, wide deviations in their heading (cid:3238) and females initially facing away from the stimulus quickly change their general heading toward it, orientation indicating superior ability to resolve the front-rear ambiguity in source location. X-ray CT scans of the moths did not reveal any internal coupling between the 2 ears, confirming for the first time that an acoustic insect can localize a sound source based solely on the distinct features of each ear.


The invention discloses an ergonomic data testing method. An ergonomic data testing system is used for testing ergonomic data of a subject and comprises an ergonomic data testing device, an upper processor as well as a data storage device, a parameter setting unit and a display unit which are connected with the upper processor. The ergonomic data of the subject are tested in the steps as follows: 1, inputting of an identity identification number; 2, reading and judgment of the identity identification number; 3, judgment of a key test project; 4, data testing and synchronous uploading; 5, data receiving and processing. The method is simple in procedure, reasonable in design, simple and convenient to implement and good in use effect, can be used for testing ergonomic data simply, conveniently and quickly, and can be used for determining the key test project of the test according to a test result obtained last time and marking a test result of the key test project.


Background: Spinal anesthesia in parturients that undergo cesarean section is a method of choice, but some patients complain about shortness of breath after surgery. This might be due to spinal block may have effect on huff cough strength resulting in the difficulty to expel the mucus from the lungs. The Mini-Wright Peak Flow Meter, the surrogate device of huff cough strength, is a bedside equipment used to assess exhalation force by its peak expiratory flow rate (PEFR). As a result, the investigators would like to know if the spinal block affected the parturient huff cough strength.

Objective: To evaluate the spinal anesthesia during cesarean section effect on the parturient huff cough strength and to find the factors that influence the difference of PEFR beside the spinal block.

Materials and Methods: The PEFR was recorded three times in 161 healthy term pregnant women at 38 to 42 weeks of gestational age that were scheduled for elective cesarean section, at preoperative, immediate after spinal block, and before discharge from the recovery room. The measurement was performed in all parturients with 15 degree left lateral tilt position and the highest PEFR achieved in three successive attempts. The spinal anesthesia with 10.75 to 11 mg of 0.5% hyperbaric bupivacaine and 0.15 to 0.2 mg morphine was performed under the standard anesthetic care.

Results: One hundred sixty-one patients successfully completed the present study. The PEFR appeared to decrease significantly after spinal block from 285.53±55.21 L/minute to 238.70±49.69 L/minute (p<0.001) and seemed to sustain till the time of discharge from the recovery room at 235.40±47.29 L/minute (p=0.493). These implied that though the patients fulfilled the discharge from recovery criteria, the level of sensory blockade was not yet improved. Interestingly, these values were comparable and showed no correlation with age, BMI, and solid sensory blockade.

Conclusion: Spinal anesthesia might affect huff cough strength in parturients that underwent elective cesarean section as evidenced by the decrease of PEFR even at the time of discharge from the recovery room.

Keywords: Bupivacaine; Cesarean section; Huff cough strength; Parturient; Peak expiratory flow rate; Spinal anesthesia


The early edge ofthe sun barely peeked over the ridge ofHogbackMountain, winking through the bristly pines before losing itself in the shadowy tangles of laurel. Lacking the strength to warm the world just yet, the sun was still a welcome sight for Sardis Miller as she climbed higher toward it, carefully holding her galvanized pails away from her legs. She had tucked the length of her skirt into the shirtwaist to make the climb easier, and she didn't want those cold buckets to touch her bare skin if she could help it. The buckets would be colder still when she'd filled them with the spring water that rang and rippled in the woods above the house, and Sardis was still sleep-warm and drowsy from the night. Shivering, hurrying, Sardis stepped high over an outflung beech root that lurked in the path. She did it without thinking, from long habit; root and path meant as much and as little to Sardis as the hair ofher head or the dented tin buckets she carried. Her feet slip-slapped against the packed dirt while her water pails jingled and danced on their wire handles. The sharpness ofthe air grew deeper as she climbed, and the warmth of the house below her was lost except for the faint breath ofwood smoke that wound through the trees. A long way off, she heard the mournful hoot ofthe mill whistle, calling the faithful, and she was glad to be high up on Hogback, free from the mill and the town and all the things that had sprung up around it. She knew nothing of stacks and smokes and days spent indoors and she hoped she never did.


The renovation of historic buildings (regardless of their preservation status) has an overarching socioeconomic impact that goes beyond the environmental or economic benefits. These benefits can be seen as public goods. Within the ATLAS project, a survey covering over 35 rural alpine municipalities was launched to gather information about the municipalities' motivation and interest in renovating their heritage building stock based on its contribution to local economy, social and environmental aspects. Moreover, the research inquired on how the municipalities define their role in the renovation process and the obstacles they face. This paper provides a summary of survey results with the aim to contribute to the understanding of the underlying considerations of rural municipalities in the Alpine region when renovating their historic building stock.


Report of the Berlin Lying-in Hospital, from October 1, 1829, to December 31, 1835. By Professor Busch. [The original Report, of which the following is a condensed analysis, occupies nearly two whole Numbers of the valuable Journal in which it appears.] This institution is attached to the university, being expressly intended by the Prussian government for clinical instruction; and has recently, it appears, been erected in a more convenient part of the town, being close behind the building of the university itself. The patients are divided into two classes,?those who are delivered in the hospital, and those who are attended at their own houses. Prof. Busch is the successor of the celebrated Elias von Siebold, and has carefully recorded everything which has been worthy of interest, both in a statistical as well


Anomalous expression of micro RNAs (miRNAs) and circular RNAs (circRNAs) were strongly correlated to the progression of multiple cancers, including multiple myeloma (MM). This study aimed to investigate whether circ_0008035 exerts its roles on MM cells by targetingmiRNA-1256. To analyze
 the levels of circ_0008035 and miRNA-1256 in MM samples and healthy bone marrow samples, a real time quantitative PCR (RT-qPCR) assay was executed. Cell proliferation and apoptosis were detected with a cell counting kit (CCK-8) and flow cytometry assay, respectively. The cell invasive and
 migration ability were assessed using a transwell assay. Dual-luciferase reporter assay and RTqPCR were applied to analyze and compare the targeting effect of circ_0008035 and miRNA-1256. Circ_0008035 was overexpressed, while miRNA-1256 expression declined in MM bone marrow tissues. RPMI8226
 cells transfected with si-circ_0008035 or miRNA-1256 mimic exhibited lower proliferation and migration capabilities, while cell apoptosis was remarkably elevated. Circ_0008035 acts as a miRNA-1256sponge and negatively controls miRNA-1256 expression. Transfection of anti-miRNA-1256 reversed
 proliferation and migration inhibition and promoted cell apoptosis, which was motivated by si-circ_0008035 transfection. Circ_0008035 negatively regulated miRNA-1256, and the circ_0008035/miRNA-1256 axis regulates the progression of MM, thus providing a potential target for MM therapy.


The explosion of online social media has increased people's ability to share content and link with others, thus allowing diverse communities to emerge naturally as a product of interaction among participants. Mothers have certainly not been foreign to this development. Many have embraced the new technology to share experiences, thoughts, current events, reactions, and tips with their peers. Recognizing the role of mothers as decision-makers in their families, especially in the context of health, we focus our attention on "mommy-communities" in Twitter and the blogosphere. We consider what health topics are discussed by mothers in these communities, identify and compare implicit affinities to explicit links, and highlight differences and similarities across the two social media platforms.


An elderly woman presented with a huge falx meningioma partially supplied by the posterior meningeal branch of the ascending pharyngeal artery, which arose from the cervical portion of the internal carotid artery. The findings in this case suggested that opacification of the ascending pharyngeal artery is important in making the diagnosis, even when supratentorial meningeal abnormalities are encountered.


Elective courses are obligatory for visiting courses at pupils' option, included in a profile training at the senior stage of a school. For a successful solving of tasks, which are imposed on elective courses system, the teacher and the pupil should have apart from a material resources (laboratory, the equipment, reagents, etc.) the full educational-methodical set of the elective course. Some fragments of programs and contents (including the list of creative projects) of elective courses "the History of chemistry" and " Introduction in pharmaceutical chemistry " are given as examples. The organization of project activity in frameworks of elective courses opens big opportunities for personal and professional experience gain


Abstract.  1. Biological invasions of exotic species pose a major threat to native biodiversity. Invaders are known to have direct impacts on native species; however, less well studied are the indirect impacts mediated through the integration of invaders into trophically linked communities.


Purpose

Stakeholders of the Architecture, Engineering and Construction (AEC) sector require information on the buildings economic performance throughout its life cycle. This information is neither readily available nor always accurate because building management (BM) professionals still face difficulties to fully incorporate the life cycle cost (LCC) concept into their daily practice. The purpose of this paper is to identify and contribute to solving these difficulties.

Design/methodology/approach

This paper provides a background knowledge review and set the ground for a structured research roadmap and a management framework that highlight the links and limitations to be addressed within and between LCC and BM. A six-stage method was used for developing conceptual frameworks targeting six goals: establishing a point of departure; mapping sources of information; literature research; notion deconstruction and conceptual categorization; overview of the applicable background knowledge; and structuring of a framework for LCC-informed decisions in BM.

Findings

Management solutions for the built context are necessarily connected with LCC and BM current concepts such as asset management, project, program and portfolio management, facility management and data management. These management approaches highlight the importance of incorporating life cycle concepts and promote LCC effective application within the AEC sector.

Originality/value

This paper identifies and discusses current limitations on the information availability for the economic performance of buildings throughout its life cycle. This work also identifies LCC-related topics that need to be further explored or addressed by both the scientific community and practitioners to overcome these limitations and facilitate the integration of the LCC concept into BM activities.


In accordance with the long-term development of Xijiang transportation and the standardization of the container ship,the technical and economic evaluation for the container ship in Xijiang river was demonstrated.The best types of ships suitable for the routes of Xijiang River were achieved by subsection of typical routes and ship's tonnages method.Research results showed that the best types of container ships is obviously better than ships now available which is outstanding as the technical and economic items are concerned.


According to an example, a cloud bandwidth modeling system may determine components for an application, create a vertex for each component in a graph representing a bandwidth model for the application, determine bandwidth requirements between each component, and create directed edges between the components to represent the bandwidth requirements.


Objective To explore the feasibility of the application of time series model to predicting the malaria incidence in China so as to provide the theoretical basis for the reduction of malaria incidence.Methods An autoregressive integrated seasonal moving average(ARIMA) model was established based on the data on malaria incidences from 2004 to 2009 in China.With the difference method used to smooth the sequence,we determined the order and established the 2010 national malaria incidence forecast model to evaluate the predicting results.Results It was found that there was a year-by-year decrease in the incidence and death rate of malaria from 2004 to 2009,and the incidence fluctuated with seasons with the peak incidence seen from July to October.Seasonal ARIMA model fitted well,and the residual autocorrelation function graph showed that the residuals were white noise sequences,which fitted well with the incidence sequences in the previous periods of time.Further prediction of the incidences in the individual months in 2010 with the model indicated that malaria incidence decreased in the year compared with the previous years.Conclusion The seasonal ARIMA model can be well applied to the fitting of data on malaria incidence with good forecasting,providing a scientific basis for the development of measures for the prevention and control of malaria.


Summary Background Patients with asthma who are inadequately controlled on inhaled corticosteroid–long-acting β 2 -adrenoceptor agonist (ICS–LABA) combinations might benefit from the addition of a long-acting muscarinic receptor antagonist. The aim of the IRIDIUM study was to assess the efficacy and safety of a once-daily, single-inhaler combination of mometasone furoate, indacaterol acetate, and glycopyrronium bromide (MF–IND–GLY) versus ICS–LABA in patients with inadequately controlled asthma. Methods In this 52-week, double-blind, double-dummy, parallel-group, active-controlled phase 3 study, patients were recruited from 415 sites across 41 countries. Patients aged 18 to 75 years with symptomatic asthma despite treatment with medium-dose or high-dose ICS–LABA, at least one exacerbation in the previous year, and a percentage of predicted FEV 1 of less than 80% were included. Enrolled patients were randomly assigned (1:1:1:1:1) via interactive response technology to receive medium-dose or high-dose MF–IND–GLY (80 μg, 150 μg, 50 μg; 160 μg, 150 μg, 50 μg) or MF–IND (160 μg, 150 µg; 320 μg, 150 µg) once daily via Breezhaler, or high-dose fluticasone–salmeterol (FLU–SAL; 500 μg, 50 µg) twice daily via Diskus. The primary outcome was change from baseline in trough FEV 1 with MF–IND–GLY versus MF–IND at week 26 in patients in the full analysis set, analysed by means of a mixed model for repeated measures. Safety was assessed in all patients who received at least one dose of study drug. This study is registered with ClinicalTrials.gov, NCT02571777, and is completed. mometasone– indacaterol–glycopyrronium (MF–IND–GLY)—in We also show versus two different ICS–LABA treatments: the corresponding ICS–LABA (mometasone–indacaterol; MF–IND), showing the additional beneficial effect of glycopyrronium; and high-dose fluticasone–salmeterol (FLU–SAL), showing the combined benefit of MF–IND–GLY versus a well-established ICS–LABA combination. The study data show the potential benefits of a once-daily fixed-dose combination of MF–IND–GLY for patients with that is inadequately controlled with medium-dose and high-dose ICS–LABA. The study also suggests that


Batu City is an agricultural area that implements an organic farming system. the emergence of organic farming system as part of a sustainable agriculture system which is one of the answers to the degradation of the agricultural environment, the dependence of farmers on the components of the green revolution and the fading of local wisdom in farmers is very important to get serious attention. The purpose of this research is to describe the perceptions and analyze the factors of adoption of innovations in organic vegetable farming in Batu City. The method of taking the population and the sample of this study were determined by the census method. The data analysis method uses descriptive analysis and Partial Least Square. The results of this study indicate that the characteristics of farmers, the nature of technology and the competency of instructors have a positive and significant effect on the adoption of innovations. The factor that has the most influence on the adoption of organic vegetable farming innovations in Batu City is the competency of extension workers. Recommendations that can be given are frequent counseling about organic agriculture and there must also be an understanding of the mindset of the extension participants so that counseling runs optimally.