This article is dedicated to study the image of Russia in the media of Eurasian Economic Union countries based on the informational-analytical system "Russia in the world" of "Russia Today". The author focuses on activity and tonality of information resources in Armenia, Belarus, Kazakhstan and Kyrgyzstan, moreover the index of their "aggressiveness" in relation to Russia. With the help of an expert survey, the problems of forming a media image of Russia in the EAEU countries were identified and recommendations were made for its improvement. The analysis of empirical data allowed the author to determine the nature of Russia's positioning in the media coverage of each country, to compile statistics taking into account positive, neutral and negative indicators. Results of the study show the level of information activity in these countries, the factors influencing dynamics of attitude towards Russia in their media fields, as well as presence of anti-Russian tendencies in propaganda of some EAEU states.


The CO activation mechanism on the χ-Fe5C2 Fischer–Tropsch synthesis catalysts is studied by spin-polarized density functional theory calculations. A series of low ((100), (010), (001), (110), (111), and (111)) and high ((221), (411), and (510)) Miller index surfaces are intensively investigated. Both the direct and H-assisted pathways through HCO, COH, HCOH, and CH2O intermediates are systematically examined on the hydrogen coadsorbed surfaces. Different activity and activation mechanisms are determined on the various surfaces as well as the varying sites. It is found that the high-index Fe5C2(510) and the relatively unstable (010) and (221) surfaces are active for direct CO dissociation due to the existence of the highly activated sites. H-assisted dissociation pathways are preferred on the Fe5C2(010), (110), (411), (111), and (111) surfaces with the moderate stability. On the relatively stable (100) surface, CO dissociation can hardly take place. Such discrimination for the activity and the CO acti...


Quantum key distribution (QKD) uses quantum mechanics to guarantee secure communication. It enables two parties to produce a shared random secret key known only to them, which can then be used to encrypt and decrypt messages. QKD is a research hotspot of international academia in recent years. We introduce some protocols: BB84 protocol, E91 protocol, SARG04 protocol.


It is shown that the sl(2)q-invariant open antiferromagnetic XXZ spin chain with a boundary field has a gapless sector in the thermodynamic limit when its length is odd. Owing to a Temperley-Lieb equivalence of the spectra, the same conclusion is drawn for the purely biquadratic spin 1 chain with open boundaries and odd length.


The development of western liberalism after World WarⅡhas been going through three stages: the cold war stage in 1950s and 1960s, the stage that dispute in liberalists was increased in 1970s and 1980s, the reform stage in 1990s. The focuses on each stage focuses reflect main social contradictions in its stage, so liberal thought in each stage has different content and characteristics.


The lack of consensus among reported molecular (gene, protein, regulatory marker) signatures (MSs) in the literature is often an initial concern for researchers and subsequently it discourages larger scale prospective studies, prevent the translation of such knowledge into a practical clinical setting and ultimately hindering the progress of the field of biomarker-based disease classification, prognosis and prediction. Understanding the high level of clinical and biological heterogeneity in patients' cohort distribution, (e.g. by diseases subtypes and stages, age, treatment methods etc), limitations and misbalances in the number of samples, and uncertainty in the dimensionality of potential biomarker space, are critical for getting the signature consensus and identification of novel potential biomarkers. Differences in use of technological platforms, as well as variations in experimental protocols in different studies are also often contributing factors in the lack of strong consensus among signatures. In view of these differences, it would be inappropriate to compare MSs in entirety. Here, we investigate each variable in the signature of interest, and attempt to generate computationally "a null frequency distribution" of the expected number of co-occurrences in other MSs, i.e. other published MSs, and identify both novel and common biomarker within the given MS. We demonstrated an application of proposed model to identification of clinically essential genes of our somatically mutated genes in breast cancer.


Yogurt with selenium-enriched Ganoderma lucidum was developed using soybean and selenium-enriched Ganoderma lucidum as raw materials,and the yogurt fomula and processing parameters were optimized through response surface method.The optimum conditions were that soybeans were immersed in 0.5 % NaHCO3 solution for 8 h at 25 ℃,ground in 6 times of water,and then mixed with milk in proportion of 3:1.Glucose(2 %),sucrose(6.3 %) and concentrated liquid of selenium-enriched Ganoderma lucidum(5%) were added into the mixture,and inoculated with 5% of Lactobacillus bulgaricus and Streptococcus thermopgilus(1:1),and fermented at 42℃ for 6.1h.Thus the yogurt with selenium-enriched Ganoderma lucidum was produced.


Background and Objectives: Marriage has always been considered as the starting point of the family and hence is a complex and very delicate form of human relationship. Commitment is one of the critical predictors of an individuals' willingness to stay in a marriage and a determinant factor regarding its time and quality. In this regard, the present study aimed to compare the effectiveness of imago relationship therapy (IRT) and Feldman's integrated approach on marital commitment in conflicting couples in Tehran, Iran.
Materials and Methods: This quasi-experimental applied research was conducted based on a pre-test, post-test, and follow-up design with a control group. The statistical population of this study included all of the conflicted couples who referred to the Department of Women's Affairs in the Post Bank of the District 6 of Tehran municipality and a Psychological Clinic in the District 22 of Tehran municipality in 2018. In total, 30 couples were enrolled in the study who were equally divided into two groups of intervention and control. The required data were collected using the marital conflict questionnaire developed by Barati and Sanei (1998) and marital commitment questionnaire developed by Adams and Jones (1997). Moreover, the collected data were analyzed using the analysis of covariance.
Results: Based on the results, both the IRT and Feldman's integrated approach affected the personal (F=27.63, P<0.001), ethical (F=69.70, P<0.001), and structural commitment (F=40.51, P<0.001). Nevertheless, IRT affected marital commitment more than the Feldman's integrated approach.
Conclusion: It can be concluded that IRT and Feldman's integrated approach can improve the marital commitment of conflicting couples.


The present investigation was carried out to evaluate the shelf life in T. asperellum tablets and capsules. Four types of tablets viz. T1 (T. asperellum talc tablet), T2 (T. asperellum charcoal tablet), T3 (T. asperellum lignite tablet), T4 (T. asperellum flyash tablet) and Six types of capsules viz. T5 (T. asperellum talc capsule), T6 (T. asperellum gelatin capsule), T7 (T. asperellum alginate capsule), T8 (T. asperellum alginate + charcoal capsule), T9 (T. asperellum gelatin + flyash capsule), T10 (T. asperellum Frozen culture mass along with disc capsule) were prepared and compaired with sorghum grains based carrier as control T11. Then observe the shelf life upto 180 days from the date of manufacturing at regular interval of 30 days. The study revealed that the desired minimum count i.e. 1 x 107 was noticed in all the formulations upto 180 days storage. Maximum cfu/g (76.33 x 107) was obtained inT10 i.e. frozen culture mass along with medium disc capsule followed by T4, T. asperellum fly ash tablet (39 × 107cfu/g). However, least cfu/g recorded in T9 T. asperellum alginate + charcoal capsules (20 × 107cfu/g). In the present study tablet and capsule delivery system of various formulations was also tried by using jaggery treatment and maximum population of T. asperellum obtained (77.66 × 107cfu/ml) in T10,T. asperellum Frozen culture mass along with medium disc capsule followed by (53 × 107cfu/ml) in T7, T. asperellum alginate capsule.


A computer simulation model of the interplay between successional dynamics and long-term nutrient retention was constructed for the purpose of comparing the retention characteristics of two southern Appalachian forest stands. Descriptions of mechanisms of competition for light, water, and nutrients included in the model were tested by comparing the 12-year average diameter increment of trees in four stands from different slope positions in the Walker Branch Watershed (WBW) with model predictions. In an assessment of long-term nutrient retention characteristics in the dry mid-slope forest of the WBW, in the Ridge and Valley Province of eastern Tennessee, losses of calcium from the soil pool during 500 years of simulation were large. In contrast, simulation of the dry mid-slope forest of the Hannah Branch Watershed (HBW), in the Great Smoky Mountains National Park, showed large losses of nitrogen and an increase of soil calcium. The differences were the result of the accumulation effects of short term imbalance between uptake and mineralization rates rather than the result of a chronic characteristic of the nutrient cycles. Many mechanisms, such as translocation alteration, tissue concentration alteration, and nitrogen fixation relationships, were shown to be capable of enhancing the adjustment of tree uptake to efficiently capturemore » available nutrients and reduce nutrient loss. This study demonstrated the importance of spatial variability from plot to plot as well as the importance of temporal dynamics in assessing the causes of nutrient losses from an entire landscape.« less


The purpose of this study is to clarify the correlation between the trust factors and PE curriculum attitude and class satisfaction on the PE teachers as by middle school students. To achieve the aim, based on the convenience sampling method, 4 middle schools located in Gyeonggi-do City were selected as the target group and surveyed 300 students. 268 questionnaires in total except 32 papers out of all collected papers were used for the actual analysis. By using SPSS Win Ver 19, we did descriptive statistic analysis, exploratory factor analysis, reliability analysis, average difference verification, correlation analysis and multiple regression analysis. Through the methods and procedures above, we received results as follows. First, the result showed the significant relation between the middle school students trust on the PE teachers and their curriculum attitude and class satisfaction. Second, the middle school students trust on the PE teachers turned out that it has partial influence on their curriculum attitude and class satisfaction. Third, the result indicated that the PE curriculum attitude of the middle school students has significant influence on the class satisfaction. To sum it up, the middle school students trust on the PE teachers affects their curriculum attitude and class satisfaction to school positively and significantly.


As biggest archipelagic country in the world, region of Indonesia it is on the right track become urgent requirement availability of adequate sea transportation service for the condition that is lessening difference in growth of economics between this region and Javas, Bali and more expanding Sumatera. Intention of researching into this, that is to conduct scheme of passenger ship with type bounce up trimaran which fittet in with the condition of Indonesia East sea region. Ship of Trimaran have excess either from economic aspect and technique aspect. Economical this ship will have more passenger and cargos to load a lot because of link structures between especial hull ( main hull) with beside hull (demi hull) can be exploited as accommodation rank. Besides from form device facet bounce up with displacement the sameness of trimaran have smaller resistance, so that fuel consumption will become smaller. Besides of it ship also kept and security, trimaran have stability which is better to be compared to conventional vessel.


This article analyzes how to make the campus network work efficiently, and hence produce an ideal effect.In addition, a general plan,as well as some solutions is discussed.


Dr. Arvind Gangoli Rao, Associate Professor, Propulsion & Power of the Faculty of Aerospace Engineering made a successful application to the Open Access fund for a book called CleanEra. A collection of research projects for sustainable aviation.

 The CleanEra project was initiated with the goal of developing revolutionary ideas for civil aviation. These ideas were to offer solutions which would limit and reduce some of the negative aspects of aviation, namely: emissions and the use of resources.

The publication, published by IOS Press in Amsterdam, turned out to be 250th application for the Open Access fund. For that reason Shervan, on behalf of the team members, was given a pluche Oxfam Goat by Just de Leeuwe, manager of the Fund.

Rao's statement on Open Access: "Societal development is accelerated by open sharing of knowledge, and open access publications facilitate this."

CleanEra is available at IOS Press as open access download and as hard copy. Naturally, it's also downloadable from the repository of TU Delft.


The invention relates to a six-degree-of-freedom unmanned combat aerial vehicle short-range dogfight method based on a simplified model machine game. The method comprises the steps that 1, a six-degree-of-freedom non-linear unmanned combat aerial vehicle Simulink model is established; 2, a six-degree-of-freedom non-linear unmanned combat aerial vehicle control law is designed; 3, an unmanned combat aerial vehicle simplified model is established; 4, an airborne cannon model is established; 5, an unmanned combat aerial vehicle control input instruction library is designed; 6, input instruction switching is controlled; 7, an unmanned combat aerial vehicle short-range dogfight machine game model based on the simplified model is established; S8, simulation verification is conducted. The method aims at providing an unmanned combat aerial vehicle aerial warfare autonomous decision-making method which has actual application value, the decision accuracy and scientificity are guaranteed, and meanwhile the decision time is effectively shortened, so that the fight power of an unmanned combat aerial vehicle is improved.


This e-book is written by Dr William J. Clark with the subtitle 'Orthodontics for You and Me'. It has been written and designed to explain orthodontic procedures to patients and parents. The author covers a wide range of orthodontic treatment including removable, functional and fixed appliances, aligners, lingual and transforce appliances, retainers and orthodontic extractions. Each treatment modality is illustrated by an abundance of full colour case photographs and supported by concise text. The photographs show very clearly the suitability of different aspects of malocclusions for each type of appliance, with an extended section on functional therapy with Twin Blocks. The book also highlights the difference that orthodontic treatment can make to a patients' facial profile, which is often unknown to the patient and their parents. References are made to prominent and weak or receding chins, concave and convex profiles. The book is written in an informal style that will be easy to read and understand for both teenagers and adults alike. There are sections including humorous dialogues and questions and answers, making it both a fun and informative read. The format of this e-book makes it very easy to present on a screen in the waiting room or the surgery to help patients and parents understand their treatment procedures and likely outcome. It can also be stored on smart phones, personal computers and tablets, which makes it easily accessible and very appealing to our current hightech generation. The dramatic improvements that are clearly evident in the post-operative photographs should act as a strong incentive, even for the most uncooperative of patients. This e-book would be a useful addition to any orthodontic office and I would enthusiastically recommend it to parents and patients, both young and old. Amy Meng Lei Dental Foundation Trainee Orthodontic Pearls


Excellent correlation was found between total amount of fluoride intake and incidence of dental fluorosis or indexof dental fluorosis or urine fluoride levels of children aged 8~12. Total amount of fluoride intake is better than content of fluoride in water or in food alone in the indication of fluorosis condition of endemic fluorosis areas.


Critical aspects of computational imaging systems, such as experimental design and image priors, can be optimized through deep networks formed by the unrolled iterations of classical physics-based reconstructions. Termed physics-based networks, they incorporate both the known physics of the system via its forward model, and the power of deep learning via data-driven training. However, for realistic large-scale physics-based networks, computing gradients via backpropagation is infeasible due to the memory limitations of graphics processing units. In this work, we propose a memory-efficient learning procedure that exploits the reversibility of the network's layers to enable physics-based learning for large-scale computational imaging systems. We demonstrate our method on a compressed sensing example, as well as two large-scale real-world systems: 3D multi-channel magnetic resonance imaging and super-resolution optical microscopy.


The acquisition of brain images in fMRI yields rich topographic information about the functional structure of the brain. However, these descriptions are limited by strong inter-subject variability. A recent approach to represent the gross functional architecture across the population as seen in fMRI consists in automatically defining across-subjects brain parcels. This technique yields large-scale inter-subject correspondences while allowing some spatial relaxation in the alignment of the brains. We address here the open question of an optimal parameterization (number of parcels) of brain parcellations using information theoretic criteria and cross-validation. Moreover, a finer analysis of variance components enables us to better characterize intra- and inter-subject variability sources in parcellation models


The Hinode/Extreme-ultraviolet Imaging Spectrometer (EIS) obtained rapid cadence (11.2 s) EUV stare spectra of an M7.3 flare ribbon in AR 12036 on 2014 April 18. Quasi-periodic (P ≈ 75.6 ± 9.2 s) intensity fluctuations occurred in emission lines of O iv, Mg vi, Mg vii, Si vii, Fe xiv, and Fe xvi during the flare's impulsive rise, and ended when the maximum intensity in Fe xxiii was reached. The profiles of the O iv–Fe xvi lines reveal that they were all redshifted during most of the interval of quasi-periodic intensity fluctuations, while the Fe xxiii profile revealed multiple components including one or two highly blueshifted ones. This indicates that the flare underwent explosive chromospheric evaporation during its impulsive rise. Fluctuations in the relative Doppler velocities were seen, but their amplitudes were too subtle to extract significant quasi-periodicities. RHESSI detected 25–100 keV hard-X-ray sources in the ribbon near the EIS slit's pointing position during the peaks in the EIS intensity fluctuations. The observations are consistent with a series of energy injections into the chromosphere by nonthermal particle beams. Electron densities derived with Fe xiv (4.6 × 1010 cm−3) and Mg vii (7.8 × 109 cm−3) average line intensity ratios during the interval of quasi-periodic intensity fluctuations, combined with the radiative loss function of an optically thin plasma, yield radiative cooling times of 32 s at 2.0 × 106 K, and 46 s at 6.3 × 105 K (about half the quasi-period); assuming Fe xiv's density for Fe xxiii yields a radiative cooling time of 103 s (13 times the quasi-period) at 1.4 × 107 K.


Contradictory findings exist on the political party preferences of intergenerationally occupationally mobile men. The argument is recast in terms of additive versus interactive models of origin and destination occupational group effects. Data from American presidential year surveys in the 1960s reveal that an additive model satisfactorily explains variance in party identification among those who are occupational stable as well as among those who are mobile; mobility per se has no effect. Additional analyses suggest that a model of selective recruitment for mobility provides a better account of the observed pattern than does a model of resocialization: the partisan-ship of those who are mobile is intermediate between those who are stable in their class of origin and those stable in their class of destination.


Often (in fact any time we do not consider the whole universe as one big system) we are interested only in subsystems of bigger systems. For example, we want to study an atom in a trap without considering all the 10 other atoms around it or we are interested only in a container of gas and are ignorant of the many degrees of freedom of some "heat bath" it is coupled to. Or we want to understand what is going on in our lab without having to worry what is going on next door.


Six new C21 steroidal glycosides 1–6 were isolated from the stem parts of Cynanchum bungeiDecne. The structures of the new glycosides were determined on the basis of spectroscopic analysis, including 1D- and 2D-NMR and HR-ESI-MS techniques as well as by comparison of their spectral data with those of related compounds.


Abstract. Achieving satisfactory overlay is increasingly challenging as feature sizes are reduced and allowable overlay budgets shrink to several nanometers and below. Overlay errors induced by wafer processing, such as film deposition and etching, constitute a meaningful fraction of overlay budgets. Wafer geometry measurements provide the opportunity to quantify stress-induced distortions at the wafer level and provide information that can be used in a feedback mode to alter wafer processing or in a feed-forward mode to set wafer-specific corrections in the lithography tool. In order for such feed-forward schemes based on wafer geometry to be realized, there is a need for mechanics models that relate in-plane distortion of a chucked wafer to the out-of-plane distortion of a wafer in a free state. Here, a simple analytical model is presented that shows the stress-induced component of overlay is correlated to a corrected local wafer slope metric for a wide range of cases. The analytical model is validated via finite element (FE) simulations of wafers with nonuniform stress distributions. Furthermore, FE modeling is used here to examine the effect of the spatial wavelength of stress variation on the connection between slope and the wafer stress-induced component of overlay.


Hydrogen radio frequency (RF) discharge was studied by optical emission spectroscopy and actinometry. The main aim of this work was the comparison of RF discharges at 2 frequencies - 13.56 MHz and 27 MHz as sources of atomic hydrogen. The power delivered to discharge was 30 W. The concentration of atomic hydrogen was determined by actinometric method in the 200 - 600 Pa pressure range with 5% argon as the actinometer. The hydrogen Hα line at 656.3 nm and an argon line at 811.5nm line were used. From the Fulcher-α band (d 3 Πu - - a 3 Σg + ) the temperature of the gas was determined. The electron temperature was determined by Boltzmann plot of the hydrogen Balmer series (Hα, Hβ, Hγ, Hδ).


Objective:To study the effects of thermal injury and twohit,induced by endotoxin,on the expression of tumor necrosis factor receptor 1(TNFR 1),and TNFR 2 in hepatic cells.To test the hypothesis that rhubarb can inhibit the expression of TNFR 1 and TNFR 2 in systemic inflammatory response induced by thermal injury and the twohit.Methods:Prospective and randomized trial.The rat burned model was used.Endotoxin at a dose of 20 mg/kg was continuously infused to animals 12 hours after burns and kept for 12 hours.The expression of TNFR 1,TNFR 2,in liver and the concentrations of TNFα,interleukin6(IL6) in plasma and hepatic tissues were observed.Results:Hybridization in situ revealed that thermal injury and the twohit induced by endotoxin could obviously increase the expression of TNFR 1 and TNFR 2 in hepatic cell surface.However,the TNFR 1 is prevailing.The rhubarb could downregulate the expression of both of the receptors.There was very high concentrations of TNFα in plasma and hepatic tissues after thermal injury and the twohit.Rhubarb evidently lowered the concentrations of TNFα in both plasma and hepatic tissues( P 0 01).It also decreased the concentrations of IL6 in plasma ( P 0 01).Conclusions:Rhubarb could downregulate the expression of TNFR 1 and TNFR 2 in hepatic cell surface after thermal injury and the twohit.It also decreased the concentration of TNFα and IL6 in plasma and hepatic tissues.


A large number of reports about cutaneous eruptions related to systemic chemotherapy have been published and their clinico-pathologic features have been described. We report a clinico-pathologic study of cutaneous lesions appeared in patients admitted on Oncology and Haematology Departments of Fundacion Jimenez Diaz during 18 months, receiving systemic chemotherapy. We review clinical features of 78 patients and histopathologic features of 28 biopsy specimens. There are some clinical pictures characteristic, although not entirely specific of chemotherapy drugs, such as eccrine squamous syringometaplasia and the presence of histiocytes with large and pale cytoplasm, that have been related with granulocyte and granulocyte-monocyte colony stimulatin factors. Currently, it has not been demonstrated any specific relationship between a histopathologic pattern and a chemotherapy drug. We report our clinical and histopathologic findings of cutaneous eruptions related with new chemotherapy drugs, as gemcitabine and raltritexed, that have been not previously described in the literature.


For a decade or so there has been a new 'hype' in educational research: it is called educational neuroscience or even neuroeducation (and neuroethics)—there are numerous publications, special journals, and an abundance of research projects together with the advertisement of many positions at renowned research centres worldwide. After a brief introduction of what is going on in the 'emerging sub-discipline', a number of characterisations are offered of what is envisaged by authors working in this field. In the discussion that follows various problems are listed: the assumption that 'visual proof' of brain activity is supposedly given; the correlational nature of this kind of research; the nature of the concepts that are used; the lack of addressing and possibly influencing the neurological mechanism; and finally the need for other insights in educational contexts. Following Bakhurst and others, a number of crucially relevant philosophical issues are highlighted. It is argued that though there are cases where neuroscience insights may be helpful, these are scarce. In general, it is concluded, not a lot may be expected from this discipline for education and educational research. A reminder is offered that the promise of neurophilia may be just another neuromyth, which needs to be addressed by philosophy and education.


Two-dimensional finite element thermal simulations of a generic rail package designed to transport twenty-one spent PWR assemblies were performed for normal transport conditions. Effective thermal conductivity models were employed within the fuel assembly/backfill gas region. Those conductivity models were developed by other investigators assuming the basket wall temperature is uniform. They are typically used to predict the maximum fuel cladding temperature near the package center. The cladding temperature must not exceed specified limits during normal transport. This condition limits the number and heat generation rate of fuel assembles that can transported. The current work shows the support basket wall temperatures in the periphery of the package are highly non-uniform. Moreover the thermal resistance of those regions significantly affects the maximum fuel clad temperature near the package center. This brings the validity of the fuel/backfill gas thermal conductivity models into question. The non-uniform basket wall temperature profiles quantified in this work will be used in future numerical and experimental studies to develop new thermal models of the fuel assembly/backfill gas regions. This will be an iterative process, since the assembly/backfill model affects the predicted basket wall temperature profiles.Copyright © 2006 by ASME


The invention provides a video data storage utilization and video data managing method and device. The video data storage utilization method includes: creating a super block in the super block area of a disk, creating disk abstracts in the abstract area of the disk, creating disk data blocks in one-to-one correspondence to the disk abstracts in the data area of the disk, wherein each disk abstract includes channel number fields and starting time fields, and the channel number of video managing equipment corresponding to the video data stored in the disk data blocks corresponding the disk abstracts are stored in the channel number fields; when a video data storage request is received, selecting idle disk data blocks for data storage, and recording the information of the video data in the disk abstracts corresponding to the data blocks. By the method, the problem that video data cannot be stored when one disk fails in the prior art is solved.


Introduction Sickle cell disease (SCD) is one of the most common monogenic disorders, affecting millions worldwide. SCD is caused by a point mutation in the β-globin gene (HBB). A single nucleotide substitution from A to T in the codon for the sixth amino acid in the β-globin protein converts a glutamic acid to a valine that leads to the production of sickle hemoglobin (HbS), which impairs the function of the red blood cells (RBCs). Allogeneic hematopoietic stem cell transplantation (HSCT) is the only available cure, but it is feasible for only a small subpopulation ( Methods For proof-of-concept, we designed CRISPR/Cas9 systems and donor templates to introduce the sickle mutation into wild-type (WT) HBB of mobilized peripheral blood CD34+ cells. To assess genome-editing outcomes mediated by CRISPR/Cas9 systems, we developed a novel digital droplet PCR (ddPCR) assay that can quantify the rates of non-homologous end joining (NHEJ) and homology directed repair (HDR) events simultaneously following the generation of DNA double strand breaks. The assay enables rapid and accurate quantification of gene modifications in HSPCs by CRISPR/Cas9 genome-editing. Specifically, Streptococcus pyogenes (Spy) Cas9 proteins, guide RNAs (gRNA), and single-stranded DNA (ssDNA) donor templates were delivered into CD34+ cells by nucleofection with optimized conditions. Different gRNAs targeting HBB near the SCD mutation site were tested, and the optimal gRNA was chosen based on high on-target activity and proximity to the mutation site. The optimal DNA donor design and concentration were determined based on the frequency of HDR events and viability/growth rate of edited cells. Treated samples and untreated controls were assayed as both single cell clones and in bulk culture. In 2-phase liquid culture, genome editing frequencies at both DNA and mRNA levels were quantified by ddPCR to confirm persistence of edited cells in the heterozygous population over time. The expression of globins and other erythroid markers were monitored using flow cytometry and real time PCR to determine if genome editing had any effect on the kinetics of erythropoiesis. Colony formation assays were used to determine the number and type of colonies following induction of differentiation. Colony ddPCR was performed to determine the genotype of edited cells. Wright/Giemsa stain was used to confirm terminal maturation of erythrocytes into enucleated RBC. Native polyacrylamide gel electrophoresis (PAGE) and high performance liquid chromatography (HPLC) were used to confirm translation of edited β-globin protein and formation of HbS. Results and Discussion We found that the efficiency of site-specific gene correction could be substantially improved by optimizing the CRISPR/Cas9 systems for genome editing. For example, with optimization, we achieved ~30% HDR rates in CD34+ cells with >80% cell viability. The HDR-modified alleles persisted in the population over the course of differentiation, and the edited CD34+ cells retained differentiation potential. Genotyping of individual erythroid colonies confirmed that up to 35% of colonies are either homozygous or heterozygous for HDR alleles. Following differentiation, treated cells express modified HBB mRNA and HbS. In addition, the off-target activity of the HBB-specific gRNAs was determined using both bioinformatics tools and unbiased genome-wide mapping techniques. Ongoing work includes the validation of gene correction in SCD patient derived HSPCs, characterization of modified cells in vitro and in vivo to assess the therapeutic potential, and analysis of long-term genotoxicity. Conclusions Based on the proof-of-concept study, we demonstrate that using the optimized CRISPR/Cas9 system and donor template, an HDR rate of ~30% can be achieved in CD34+ cells. The gene corrected cells have the potential to differentiate into erythroid cells that permanently produce WT β-globin. Our findings provide promising evidence for clinical translation of the HSPCs genome correction strategy in treating SCD patients, as well as correcting gene defects underlying other inherited single-gene disorders. Disclosures No relevant conflicts of interest to declare.


This article is structured as a scientific text, with an introduction to the subject and a brief explanation of the technological tools used for diagnostics and analysis of built assets, continuing with the methodology for consulting sources and handling data. It then describes the information generated by the studies referred to herein, concluding with contributions that could be useful for the conservation of the built heritage through the use of technological tools for diagnostics and analysis as a methodology for the mitigation of risk and vulnerability.


An application of a supervision system made up of ultrasonic sensors and fuzzy logic is presented. In fact, the combination of both technologies permits us to endow the robot with capacity to detect presence of an obstacle in a dynamic environment and to decide if an alternative path is necessary. Furthermore, given that the echo signal data can be used to obtain an approximation of position, direction of movement and velocity of the object, the fuzzy controller can be used to select "a secure point", changing the current trajectory.


Abstract : The roles of estrogen and estrogen receptor (ER) in normal mammary gland development and in transformation to a tumor phenotype have been extensively studied. However, although the cumulative data suggests an important role for ER in breast cancer, the function of ER in regulating cell proliferation in normal and tumor tissue remains unclear. This study investigates the role of ER-alpha on the progression of the cells through different phases of the cell cycle in the presence and absence of its ligand, estradiol. The cellular localization of ER-alpha is also examined during cell cycle transition in MCF-7 cells. Experimental Design: The ER negative MDA-MB 231 and ER positive MCF-7 cell lines were used for study. Cells were synchronized in G1 phase of the cell cycle with lovastatin for 36 hours in estrogen free media and subsequently released from arrest with mevalonate. Transient transfection of MDA MB 231 cells with ER-alpha as well as addition of 17- estradiol to the cells were performed at the time of release from cell cycle arrest. Cells were harvested at different time intervals (0-68 hrs) after the release and subjected to western blot and flow cytometry analysis. For immunofluorescent detection of ER-alpha MCF-7 cells cultured on coverslips, synchronized with lovastatin and stained with anti-ER alpha antibody. Cells stained to look at ER-alpha in the cell. Results: Synchronization of MCF-7 cells revealed that the endogenous ER is subject to cell cycle regulation with its levels peaking at the S/G2 phase of the cell cycle. Similarly, MDA-MB231 cells transiently transfected with ER-alpha demonstrate tight cell cycle periodicity similar to that seen with cyclin B. Specifically, ER-alpha is up-regulated during late S phase and early G2 phase, and is down regulated during late G2 and M phases. In contrast, in non-synchronized MDA-MB 231 cells, exogenously transfected,


Abstract : This monograph examines U.S. Joint doctrine for operational deception (Joint Pub 3-58: Joint Doctrine for Military Deception). The monograph provides information to operational planners on deception concepts that are unique to Joint doctrine and how these concepts can be used when planning operational deception. The monograph provides historical examples of operational deception by briefly examining deception operations in the Napoleonic Era, WWI, WWII, and the 1973 Yom Kippur War. The monograph compares unique Joint deception concepts with the deception operations performed by USCENTOOM in the Persian Gulf War. The monograph also compares Joint doctrine for operational deception with the earlier doctrines of the four U.S. Services. The monograph concludes that USCENTCOM's operational deception in the Persian Gulf War is in concordance with subsequent Joint doctrine. Based on historical examples, the monograph makes recommendations for planners to consider when planning for and conducting operational deception. The monograph suggests changes to Services' doctrine for military deception.


Volatile aroma components in leaves grown by applying 6 different proportions of combined application of organic fertilizer and chemical fertilizer were tested by GC/MS method to comprehensively improve aroma quality of leaves from all stalk positions in flue-cured tobacco.Results showed that application of 75% chemical fertilizer and 25% sesame seed cake fertilizer resulted the highest content of neophytadiene (1068μg·g-1) in lower position leaves,while application of 50% chemical fertilizer and 50% sesame seed cake fertilizer had the highest content of neophytadiene (1066 μg·g-1,971.5486 μg·g-1 respectively) in cutters and topper leaves.Application of 50% chemical fertilizer and 50% sesame seed cake fertilizer also resulted the greatest total carotenoid catabolites in all positions,especially the content of β-damascenon,farnesyl acetone,four isomers of megastignone,higher content of maillard reaction products and aromatic AA catabolites in three postions,and greater (35.1568 μg·g-1) total of cembratriendiol catabolites in topper leaves,lower total (31.7479 μg·g-1,20.5705 μg·g-1,respectively) in lower leaves and cutters.The application of 50% chemical fertilizer and 50% sesame seed cake fertilizer was more effective than 100% chemical fertilizer to increase content and harmony of aroma components,and hence improveing tobacco quality.


PURPOSE
sPLA2-IIa is a biomarker for many inflammatory diseases in humans and is found at high levels in human tears. However, its role in ocular surface inflammation remains unclear. An experimentally induced BALB/c mouse dry eye (DE) model was used to elucidate the role of sPLA2-IIa in ocular surface inflammation.

METHODS
BALB/c mice were subcutaneously injected with scopolamine and placed in a daytime air-drying device for 5 to 10 days. Control mice received no treatment. DE status was evaluated with tear production with a phenol-red thread method. Tear inflammatory cytokines were quantified by multiplex immunoassays. Ocular surface inflammation and sPLA2-IIa expression were examined by immune-staining and quantitative (q)RT(2)-PCR. Conjunctiva (CNJ) of the mice was cultured for prostaglandin E2 production induced by sPLA2-IIa with various amount of sPLA2-IIa inhibitor, S-3319.

RESULTS
Treated mice produced fewer tears and heavier corneal (CN) fluorescein staining than the untreated controls (P < 0.001). They also revealed lower goblet cell density (P < 0.001) with greater inflammatory cell infiltration within the conjunctiva, and higher concentration of tear inflammatory cytokines than the controls. Moreover, treated mice showed heavier sPLA2-IIa immune staining than the controls in the CNJ epithelium, but not in the CN epithelium or the lacrimal gland. Treated mice exhibited upregulated sPLA2-IIa and cytokine gene transcription. Furthermore, CNJ cultures treated with sPLA2-IIa inhibitor showed significantly reduced sPLA2-IIa-induced inflammation.

CONCLUSIONS
This is the first report regarding sPLA2-IIa in the regulation of ocular surface inflammation. The findings may therefore lead to new therapeutic strategies for ocular surface inflammation, such as DE disease.


This study aims to find out how the influence of themodel Interactive Demonstration onabilities Scientific Investigationof high school students in environmental pollution material. This type of research is quasiexperimental with 2 class research samples taken from class X MA in one of Sukabumi Districts. The research sample was taken by purposive sampling technique. The research design used in this study is Posttest Only Control Group Design. The instruments used in this study werequestions in scientific investigationthe form of multiple choice tests of 10 items, each of which was declared valid and reliable, observation sheets and questionnaires. Based on the prerequisite test, it is known that the results of the research data are normally distributed and the two classes have the same variance (homogeneous). Analysis of scientific attitude data through ability tests obtained an average value for the experimental class that is equal to 73.81, while the control class is 72.08. The results of the average value for the experimental class observation sheet are 3.57, while the control class is 3.32. Based on the test results indicated on the SPSS output in thetable coefficients, it is known that the value of t is 0.542 with a significant value of 0.047 (meaning that the significant value is <0.05) means that H0 is rejected and Ha is accepted. it can be concluded, meaning that there is a very significant effect of the application oflearning mode interactive demonstration to theabilities scientific investigation students'.


The construction and performance of a neutron Weissenberg camera for temperatures down to 4 K is described. Exposure times are similar to the X-ray case. The background from the cryostat walls can be eliminated. Examples of applications in the fields of magnetic structures which are incommensurate with their chemical unit cells, crystallographic phase transitions and diffuse scattering are presented.


Two discussions of a technical note with the aforementioned title by Poh and Broms, published in this journal (Volume 9, Number 1, February 1995), are presented. The first discussion focuses on the authors' technique of soil stabilization, which incorporates the use of used rubber tires. The second discussion notes three limitations to the authors' design: 1) the retaining system is not interconnected; 2) the drainage system is at the front of the wall; and 3) surface drainage is not deflected away from the wall. Discussions are followed by closure from the authors.


Objective.— This post hoc subgroup analysis evaluated scheduled short‐term preventive frovatriptan therapy for women with migraine occurring exclusively in association with menstruation (occurring day −2 to +3; day 1 = menses start, no migraines outside this window).


Light can be used to address electrochemical reactions on a monolithic semiconducting electrode with spatial and temporal resolution. Herein, such principle was used for the electrodeposition of Au, Ag and Cu nanoparticles on a unique silicon-based electrode. The parallel nature of the process granted manufacturing speed and platforms were applied to discriminate molecules via multi-wavelength and multivariate Raman analysis.


Two bracing type MV gas switches are designed,the cantilever switch has a cantilevered HV electrode sealed in the brace insulating cylinder,the section-brace switch has an HV electrode spreading out of the brace insulating cylinder.Through self-breakdown experiment and electrostatic field simulation,the optimization of insulator envelop is discussed.The result indicates that the section-brace switch is safer and stabler than the cantilever switch.The reason of puncture in insulator cylinder of cantilever switch is that the stream formed in switch is accelerated by the electric field and then strikes the surface of outer cylinder.Bradley formula with field enhancement factor is given and it accords well with experimental data.


this book) and rethought the entire concept. On the second round, the results were stunning. Hudson's Northland (1952-54) became one of the most heralded of the early regional shopping malls and launched its architect on a fast-accelerating career as a kingpin of commercial design. But even when he became an acknowledged leader in the design of regional malls, Gruen came under attack from those with opposing viewpoints. He strenuously advocated his commitment to the shopping center as a focus of community, a vibrant place, filled with human interaction, enlivened by art, landscaping, vendors, meeting facilities, and other features inspired by recollections of his native Vienna. Hudson's and a number of other retailers around the country embraced his vision. So did some developers, most notably James Rouse, who was profoundly affected by Gruen's perspective—a relationship noted, but regrettably not explored, in the text. Many other retailers argued for a more pragmatic approach, oriented solely toward efficient merchandising. Some of Gruen's colleagues concurrently built their careers on regional malls that met this more austere objective. The leaders among them were Seattle-based John Graham, whose Spartan design for Northgate (1948-50) helped set the industry standard, and Welton Becket from Los Angeles, who captured much of the regional trade denied Gruen and soon became prolific nationwide. Gruen would have loved nothing more than to be the sole center of attention, as Hardwick allows him to be, but the Mall Maker was part of a more complex and difficult scene in which the seemingly casual, effortless environments for middle-class consumerism were created during the two decades after the Second World War.


This thesis presents the results of an analysis of a sample of the lithic material recovered from the Ironbark Site Complex, located on the southern Curtis Coast, central Queensland, excavated under the auspices of the Gooreng Gooreng Cultural Heritage Project. The aim of the study was to determine a possible site function for the complex. This was achieved through a combination of technological and descriptive investigation techniques. I demonstrate that a level of standardisation of the reduction sequence is evident at the site in several technological and descriptive indices. Based on this evidence, a possible use of the site was established as the manufacture of edge-ground axes. This evidence is then evaluated in terms of exchange and social significance and more generally in terms of archaeological approaches to quarry studies.


Landslides constitute natural disasters that occur in Indonesia. In General, a landslide occurred in areas of unstable slopes, and one of the causes of the occurrence of landslides is the intensity of the precipitation that falls. Another factor is the cause of the occurrence of landslides is fissures and temperature. The system is built is the application of ELo (Early Warning System Longsor) android-based, which can provide information for the benefit of the community in the form of a related prototype android application and monitoring. Early warning of catastrophic landslides, allows the existence of anticipation from the public so that the level of losses incurred would be minimized and could increase public knowledge about the catastrophic landslide. Mobile applications created with the java programming language by using the IDEA of 2.3.3 Keyword: Mobile Applications, Android, Landslides, Elo (Early Warning System Longsor)


A set of indicators for a comprehensive evaluation of large-scale irrigation areas are established and the indicators' weight through analytic hierarchy process and entropy method is determined.Based on the data from 13 large-scale irrigation areas in Jiangxi Province,approximate grey correlation and near-ideal solution methods are used to make a comprehensive evaluation of performance,results of the two methods are basically the same.Based on the evaluation results,the characteristics of the two methods are discussed and the gap between the irrigation areas and the direction for improving the performance level are suggested.


We studied the dependence on the dissociative ionization of H2 as a function of carrier-envelope phase (CEP) of few-cycle (6 fs) near-infrared (NIR) laser pulses. For low-energy channels, we present the first experimental observation of CEP dependence for combined dissociation yield (with protons emitted in both directions) and the highest degree of asymmetry reported to date (40%).


Part 1 of this study is a descriptive analysis of the spreading of Mediterranean Water based on high-resolution maps of salinity and density in the eastern basin. In this second part of our study, velocity fields for two representative isopycnal surfaces of the Mediterranean outflow (o-0. s = 29.70 and o-0. s = 29.90) are estimated from a diagnostic model that combines climatological hydrographic data from the National Oceanic Data Center with long-term direct measurements of water exchange through the Strait of Gibraltar. The model is constrained by geostrophic dynamics, conservation of mass, no- flux conditions at the continental shelf, and specified flow through the Strait of Gibraltar. Our principal data source is a recently assembled database of the North Atlantic that consists of climatological mean property fields averaged on isopycnal surfaces. The mean fields are based on more than 80 years (1909-1990) of data and have a nominal horizontal resolution of 0.5 o . To provide boundary conditions at the Strait of Gibraltar, we use the results of a model developed from data collected during the Gibraltar Experiment in 1985. The estimated velocity fields show Mediterranean Water exiting the Strait of Gibraltar, following the southern Iberian coast, and then entering the Tagus Basin, where it turns anticyclonically to create a reservoir of this water mass. The flow continues northward along the eastern boundary, penetrating into the Rockall Channel. Finally, the model flow fields do not show a significant westward advection of Mediterranean waters into the subtropical gyre.


The analysis on the mismatch between transportation equipments and operation condition, more throttling loss and power consumption in Qinhuangdao-Beijing Oil Pipeline is made. This problem comes from the Jidong Crude's blended transportation in this pipeline which results in 16% decrease in oil throughput in Qinhuangdao-Qian'an pipeline section. In allusion to this problem,the corresponding technical measures for short-term and long-term optimized operation programs are worked out.


The Bachelor thesis deals with motivation that leads foreign students to study in another country and specifically at Tomas Bata University in Zlin. At the same time work focuses on the adaptation of these students to the new environment. The first part of the thesis explains the concepts related to motivation to study, adaptation to the new environment and tertiary education. Closer describes Tomas Bata University in Zlin and foreign students, who study here in the long-term study programs. The empirical part includes an analysis of interviews with the long-term foreign students of the Doctoral study program and subsequently evaluation of qualitative research of given topic. The result of this work is a comprehensive view on the motivation that leads foreign students to study abroad. Closer defines the main reasons that prompted students to choose to study at Tomas Bata University in Zlin and presents recommendations for increasing the number of students at this university. At the same time the thesis describes the process of adaptation of foreign students to the new environment.


traditionally been poorly taught in most engineering courses. The book was conceived as a way of providing an engineer with a deeper knowledge of dynamic analysis and it indicates to them how some of the new vibration problems can be solved." Starting with the elementary basis of vibration, it continues to the more advanced and includes the latest random vibration and its variants accompanied by detailed applications. Although small in the number of pages for the topics covered, it does encompass a tremendous amount of territory in a well-explained fashion. The book consists of 17 chapters.


The paper deals with the relationship between the level of fertility and the place of residence . To verify the existence of urban-rural differences existing independently from socioeconomic differences of urban and rural population, the cohort data for Slovenia are used . They represent the intensity of fertility by place of residence as well as by socioeconomic status . While appropriate data are available only for very small territorial units, cluster analysis is used to form typological groups in which every social group is numerically large enough to be compared with the same group in other clusters . The results confirm the arguments of those who consider the place of residence as the most important determinant of low fertility in advanced societies .


Purpose – The Gulf Cooperation Council (GCC) countries have consistently ranked high in per capita carbon emissions, not to mention the fact that a lifestyle with a high ecological footprint in a fragile ecosystem can affect the regional environment, prosperity and social stability. The adoption of carbon capture and storage (CCS) in the GCC countries has been consistently gaining attention, as it is widely seen as a suitable mitigation measure, particularly in a region where heavy industry and geological exploitation have led to wealth and prosperity. Additionally, making captured CO2 available for enhanced oil recovery is expected to create significant economic value. However, the lack of a coordinated environmental regulation regime to cap future carbon emissions is posing significant risks for further CCS development. The paper aims to discuss these issues.Design/methodology/approach – This paper reviews the state of play with regard to CCS in the GCC region and investigate the opportunities and chall...


Assume that M is a closed surface and N is a compact Riemannian manifold without boundary. Let uα : M → N be the critical point of Eα with Eα(uα) < C. Assume u0 is the weak limit of uα in W (M,N) and x1 is the only blow-up point in Bσ(x1) ⊂ M with n0 bubbles. Then, on a local coordinate system on Bσ(x1) which origin is x1, we can find sequences xiα → 0, λiα → 0 (i = 1, · · · , n0) s.t. uα(xiα + λiαx) → v, where v are harmonic maps from S to N . We define μi = lim inf α→1 (λiα) . We will prove that lim α→1 Eα(uα, Bσ(x1)) = E(u0, Bσ(x1)) + |Bσ(x1)|+ n0 ∑ j=1 μ2jE(v ). Further, when n0 = 1, we define ν = lim inf α→1 (λ1α) − √ , then we have: If ν = 1, then u0(Bσ(x1)) ∪ v(S) is connected; If 1 < ν < +∞, then u0(Bσ(x1)) and v(S) are connected by a geodesic with length L = √ E(v) π log ν. If ν = +∞, the neck contains at least one geodesic with infinite length. We also give an example of neck which shows the neck contains at least one geodesic of infinite length. Mathematics Subject Classification: 58E20, 35J60.


Reconstructing the early history of species divergence and quantifying the level of standing genetic variation in diverging populations are central to our understanding of ecotype formation and ultimately speciation. In this study, we used single nucleotide polymorphisms to reconstruct the evolutionary history of species divergence in coastal dune populations of the widespread terrestrial orchid Epipactis helleborine and to investigate the level of standing genetic variation in 29 coastal dune populations in a fragmented dune landscape along the Belgian and French coast. Additionally, we used seed introduction experiments to assess the potential for gene flow into existing populations after long-distance seed dispersal and the ability to colonize vacant sites. Our results showed that coastal dune populations diverged only recently from inland populations, went through a significant bottleneck and were most probably the result of a single colonization event. Current levels of population genetic diversity are low and not related to population size or spatial isolation. The sampled dune populations also showed little genetic differentiation, and no apparent spatial genetic structure was observed. Seed introduction experiments showed that seeds of coastal dune populations germinated easily in both occupied and unoccupied sites in dune habitat, indicating that the availability of suitable mycorrhizal fungi is not limiting the distribution of coastal dune populations and that gene flow through seeds has probably contributed to the observed low levels of genetic differentiation. Overall, these results are consistent with a process of genetic divergence after a single, recent colonization event, followed by extensive gene flow among populations.


The penylethylene was reacted with bromine water,finally it was changed to 1,2-dibromo-phenylethane.Then it was separated with the wide-bore capillary columns FFAP and detected by electron capture detector.Compared with standard examination method for drinking water quality,the sensitivity enhanced 20 times.


Frege's so-called "Regress Argument" is closely examined and it is argued that Dummett's reconstruction of it is not satisfactory. Contra Dummett, the argument does not involve a regress, is not a reductio and not even a strictly deductive argument. Rather, what Frege tries to show is that any attempt to define truth fails to be epistemically fruitful and thus misses the very point of analytic definitions of concepts. The cause of this epistemic sterility is an inherent circularity, and it is in view of this defect that Frege suggests that truth is very likely so simple that it cannot be defined at all. This circularity, in turn, is due to the fact that Frege takes the sense of "true" to be a constitutive part of the content of acts of thinking a complete thought. Finally, I trace Frege's belief in this omnipresence of the sense of the word "true" in thought to his conception of judgment and suggest that it may very well be false.


Blade film cooling is one of the best methods to improve the efficiency of gas turbines. As a fundamental study, the effects of jet aspect ratio are numerically simulated here at jet injection angles of 30° and 90° and velocity ratio of 0.5. Incompressible, stationary, viscous, turbulent flow is assumed. For simulation of jet injection angle of 30°, the STAR-CD CFD software with standard ε − k model is used. For simulation of jet injection angle of 90°, a software is developed by authors (CFDARI), which uses Reynolds stress model (RSM) for turbulence modeling. Both of these codes use a cell centered finite volume method on a non-uniform structured staggered grid. The jet flow Reynolds number, based on the jet's hydraulic diameter, was 4700. The study of jet aspect ratio shows that, stretching the hole in spanwise direction increases the film cooling effectiveness. In addition at the injection angle of 30°, the more the rectangular section stretches in spanwise direction, the more rapidly the cooling effectiveness increases. Key-Words: Film Cooling, Gas Turbine, Computational Fluid Dynamics, Jet Aspect Ratio, Jet Injection Angle Nomenclature D Side of the Jet Exit (0.0127m) R Velocity Ratio ( CF Jet V V ) η Film Cooling Effectiveness; ) ( ) ( CF Jet CF AW T T T T − − θ Film Cooling Efficiency; ) ( ) ( CF Jet CF T T T T − − ( )CF, Jet Designates Cross Flow and Jet, respectively ( )AW Designates Adiabatic Wall


This paper discusses how to use software technology and algorithm to solve the problem of network traffic, based on Cisco netflow technique. One is about rapid visit and update of memory data, the other is the algorithm of TOPN sorting. Readers of this article need both knowledgs of Netflow technique and software development.


The present invention addresses the issue of providing a processing liquid that has excellent residue removal performance and excellent corrosion resistance against metal layers containing Co and is capable of suppressing the occurrence of defects. The present invention also addresses the issue of providing a substrate cleaning method and a resist removal method. The processing liquid is for semiconductor devices and contains a fluorine-containing compound, an anticorrosion agent, and calcium. The calcium mass ratio content relative to the fluorine-containing compound content in the processing liquid is 1.0 × 10 -10 - 1.0 × 10 -4 .


Airborne sonic pressure in an open or sealed housing enclosing an aquarium was measured in the air and in the water. Effective impedance differences were 9.1 dB with the housing open and 4.5 dB with the housing sealed. Both conditions indicated an effective impedance difference considerably less than the 35.5 dB impedance difference between air and the open ocean. Prevalent use of sonic fields in small aquariums thus require detailed calibration of sonic fields in tanks where the air‐water interface is tranversed. The middle ear apparently functions primarily to transduce airborne sonic pressure into displacement in the cochlear fluids, rather than to match sonic pressure impedance.


This article seeks to introduce the debate on the announced "knowledge society" and to reflect on the origin of its contradictions, taking as theoretical and methodological references the categories of Italian Marxist thinker, Antonio Gramsci. It is founded on the basic economic, political, and ideological contradictions of the globalized world. It is understood that in the condition of a dependent country, it is fundamental to reflect on the contradictions of this globalized world and their impacts on the historical specificity of Brazilian society in order to find elements for an effective action to overcome those contradictions.


Thank you very much for reading tunable solid state lasers. As you may know, people have search numerous times for their favorite novels like this tunable solid state lasers, but end up in infectious downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they cope with some harmful virus inside their computer. tunable solid state lasers is available in our digital library an online access to it is set as public so you can get it instantly. Our digital library saves in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Merely said, the tunable solid state lasers is universally compatible with any devices to read.


The problem of propagation of plane electromagnetic waves, impinging at a certain angle on a linear, lossless, dielectric slab in vacuum, is solved in the framework of molecular optics. An integral method is used, by which reflection, refraction, and transmission are seen to arise from superposition of the incident field and the wavelets radiated by the induced polarization. The physics of the radiation‐matter interaction and the origin of external and internal Brewster angles is emphasized.


The project is about finding a real time solution for the problems caused by the chalk pieces used in the class room. To overcome the problems that are faced daily by the students and faculty, the project entitled 'Real Time Automatic Blackboard Eraser using Embedded System' has been suggested to automatically erase the blackboard. DC motors of three different types are used for the movement of the instrument. The instrument moves forward and backward erasing the board and collecting the dust automatically from the erasing material due to the rotation of the roller. These processes are automated using PIC16F877A microcontroller. Thus the device avoids the dust flow in the environment and thereby providing good solution for the problems faced by the student, faculty and other electronic equipments that are used inside the class room in a cost effective and time efficient way. I. INTRODUCTION Blackboards are used in the class room for teaching purpose. These blackboards form the basis for an effective learning in the class room environment. Chalk pieces are used to write on the blackboard. The chalk powder obtained from the chalk pieces while erasing the blackboard, when inhaled by human cause problems to the respiratory organ. The Asthma patients and those who are allergic to dust cannot sit near the blackboard. Based on the problems faced by the faculty and the students, a case study was made. The case study illustrated about major issues, caused by chalk dust which can accumulate in the human respiratory system and cause problems. Other than this there are few more issues like hair loss, burning of eyes etc. Manual work is needed to clean a board which further extends time consumption while taking classes. Moreover chalk dusts not only harm the human but also the machines. Equipments that are used in the class rooms like projectors when exposed to the chalk dusts which is not heavy get easily settle on the equipments. This is one of the reasons for heat production in the equipments, when large amount of heat is produced the equipment may wear out before its actual life period ends. The Real Time Automated Blackboard Eraser can be used in the class rooms to avoid the above faced problems and to modernize the class rooms. II. LITERATURE REVIEW The common practice of erasing the blackboard is by using a black board eraser which is a hand held object, normally called as dusters and cleaning of the blackboard by a damp cloth is, of course, a technique that has long been employed but is only used when immediate use of the blackboard is not required. Some efforts have been made to improve the materials used in erasers, although such improvements still require manual manipulation of the eraser in the erasing of the blackboard. The above mentioned erasing methods erases the board, at the same time releases the chalk dust in to the environment. The chalk pieces are made of lime stone and other chemical components which is harmful to health when exposed to larger content. The class room becomes untidy with those dusts. Though dust free chalk pieces are being manufactured they produce few amounts of chalk dust lesser than normal chalk pieces but still there are possibilities for the dust accumulation. Hence the automated blackboard eraser can be used to avoid the above problems and to reduce the manual work.The Fig 2.1 shows the untidy class room caused due to the chalk dust.


Wireless-powered mobile edge computing (WP-MEC) can provide the wireless devices (WDs) with computing service and energy supply. However, the WP-MEC systems generally suffer from the dilemma of the trade-off between energy harvesting and task offloading efficiency since the two tasks are usually implemented during different time slots. In this paper, we propose to use the full-duplex (FD) technique at the hybrid access point (HAP). Specifically, the FD HAP can broadcast wireless power and receive the tasks over the same frequency band simultaneously. The time allocation, HAP transmit power, local computing frequencies and transmit power of the WDs are jointly optimized to maximize the sum computational bits (SCBs). For the case with perfect self-interference cancellation (SIC), the alternating optimization (AO) method is exploited. In addition, we extend the AO for the case with imperfect SIC. Our numerical results show the benefits of exploiting FD technique to the WP-MEC systems.


Statistics is one of the branches of mathematics that is used in almost all professions, in order to estimate more efficient and optimal processes and services, product improvements, processes, or quality of care. Its wide variety of uses makes it a tool of great demand in the knowledge of professionals, in addition to the application of quantitative research, it is a fundamental element for data management. In this work, a detailed bibliographic review is presented, which includes the analysis of statistics in different professional areas and its relevance in research processes. The most outstanding results show that the use of statistics offers better insights into research processes and a better understanding of scientific proposals.
Keywords: Use of statistics, quantitative research, data management.


"Thank you very much Dr Sartor. Now can we open up for any questions and discussion. J think you have shown very nicely that apart from the G-protein knock-out mice all the other models develop inflammation largely due to interaction with microbiological agents. You have shown that they have high levels ofTFN-y and no increase in IL10 whereas in the human disease. as Steve mentioned before, most of us even using RT-PCR have not been able to find the increase in IPN-y which we might have expected. Marginally elevated maybe. But there's actually plenty of IL-10 around. so it's a very different picture from that of genetically engineered models . And the question arises, what happens when you look at IPN-y and lL-10 in infectious colitis? We certainly haven't done that, has anybody else done it ?"


The authors examine banking efficiency before and after liberalization, drawing on Turkey's experience. They also investigate the scale effect on efficiency by type of ownership. Their findings suggest that liberalization programs were followed by an observable decline in efficiency, not an improvement. During the study period Turkish banks did not operate at the optimum scale. Another unexpected result was that efficiency was no different between state-owned and privately owned banks. Banks that were privately owned or foreign owned had been expected to respond better to liberalization, because they were smaller and more dynamically structured, but they were no more efficient than state-owned banks. One reason for the systemwide decline in efficiency might have been the general increase in macroeconomic instability during the period studied.


In this paper, the influence of the modification method applied to ground vulcanizate (GV) on the properties of elastomeric compositions based on nitrile rubber is discussed. Modified GV has been mixed with the elastomeric composition, which is used for the manufacturing of oil-petroleum-resistant rubber products.The work takes into consideration two types of GV with different chemical nature. The first GV type is rubber crumb produced from end-of-life tires. The second GV type was obtained from rubber wastes based on nitrile rubber. Three methods of the modification are compared in the research: mechanical activation in a planetary ball mill, swelling in a Polyethylene glycol (PEG-400) medium, and the mechano-chemical transformation of GV with PEG-4000. It is shown that depending on the dosage addition of GV modified with PEG-4000 reduce the compression set up for (16.1±0.7%), the strength decreases only by 2.1–8.3%, and the elongation at break increases by 0.8–10.3% compared to rubber without additives.


The spate of suicides and riots in unemployment-stricken towns has recently brought to the public attention a feature of joblessness which had not figured in the minds of those that thought it would only have financial and probably minor social consequences. Since then, a flurry of interest has been spurred by the media who regularly report on studies that show some association between unemployment and ill health, quite often, and not surprisingly, to make party political meal of a long-term problem that is bound to have implications for health provision in this country, at least over the next two decades. As psychiatrists we all know the central role played by regular, satisfying employment in the mental health of our patients, and I am sure many of us are affected by our total inability to secure adequate rehabilitation alternatives on which we are sure our patients' future, and that of their families, depend to a great extent. Some of us may also have been aware of the increased demand on mental health resources over the past few years and of the worrying tendency for admissions into psychiatric hospitals to be prolonged as a result of the time it takes for an ex-psychiatric patient to re-enter the labour force.


In this paper we prove, under certain condition, when R is a semiprime ring with suitable characteristic restrictions, that every nonzero (m,n)-Jordan triple centralizer (resp., (m,n)-Jordan triple derivation) is a two-sided centralizer (resp., a derivation which maps R into Z(R)). This give partial affirmative answers to two conjectures of Vukman.


From 95% alcohol extract of Ascidian Styela clava, collected from the shallow bay near Qingdao City, Shandong Province, six compounds, named, isovaleramide (1), thymine (2), thymidine (3), uracil (4), 2'-deoxyuridine (5) and α-palmityl glycerin ether (6) were isolated,. Their structures were elucidated by various spectral analysis (IR, MS, ~1HNMR, ~(13)CNMR) and comparison of chemical and physical data with authentic samples reported in literatures. All of these compounds are first reported to be isolated from Ascidian Styela clava.


Mineralogical and geochemical investigation of zircon from diorite porphyry from Sergozerskoe occurrence has been carried out. Study of morphology and inner structure of zircon crystals in back scattered electron rays as well as assaying for content and distribution of Rare Earth Elements in mineral grains have given important information about conditions of crystallization and following metasomatic alteration of zircon. Zircon characteristics show that it crystallized in a melt, enriched in fluid phase. Fluid influence lasted after zircon crystallization, this reflected in uneven composition of the mineral and in configuration of REE spectra, typical for metasomatic zircon. Similar zircon characteristics have been noted in zircons from other gold occurrences in greenstone belts in the Kola region. Ключевые слова: золоторудное месторождение, циркон, геохимия, минералогия, Кольский регион.


BACKGROUND AND AIMS
Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury including steatohepatitis/NASH. However, the evidence supporting these claims has been controversial. A comprehensive, fundamental understanding of cell death pathways involved in liver disease critically underpins rational strategies for therapeutic intervention. We sought to define the role and relevance of necroptosis in liver pathology.

METHODS
Several animal models of human liver pathology including diet induced steatohepatitis in male mice and diverse infections in both male and female mice were used to dissect the relevance of necroptosis in liver pathobiology. We applied necroptotic stimuli to primary mouse and human hepatocytes to measure their susceptibility to necroptosis. Paired liver biospecimens from patients with NASH, before and after intervention, were analysed. DNA methylation sequencing was also performed to investigate the epigenetic regulation of RIPK3 expression in primary human and mouse hepatocytes.

RESULTS
Identical infection kinetics and pathological outcomes were observed in mice deficient in an essential necroptotic effector protein, MLKL, compared to control animals. Mice lacking MLKL were indistinguishable from wild-type mice when fed on a high fat diet to induce NASH. Under all conditions tested we were unable to induce necroptosis in hepatocytes. We confirmed that a critical activator of necroptosis, RIPK3, was epigenetically silenced in mouse and human primary hepatocytes and rendered them unable to undergo necroptosis.

CONCLUSIONS
We have provided compelling evidence that necroptosis is disabled in hepatocytes during homeostasis and in the pathological conditions tested in this study.


This paper gives an introduction to the ore resources,geological works,investment and mining policies of Russian federation,analyzes its pros and cons in mining sector and presents suggestions for Chinese mining investors.This paper recommends that the Chinese mining investors should strengthen their management and risk awareness under the guidance of the government,using the law to safeguard their own interests,resolving the issue of environmental protection,actively looking for investment opportunities of the Russian mining market.


Objective To determine the grating acuity of healthy preterm infants by using the Closed-Circuit Operant Preferential Looking System (COPL) and to investigate visual development during the early 6-month period after birth.Methods In this prospective case-control study,the COPL was used to determine the monocular and binocular grating acuity of 48 preterm infants (25 males,23 females),who met the eligibility criteria of 7 days-8 months old,with birth weight from 1415 g to 2770 g (2233.4±448.0)g.The infants were measured periodically.The grating acuity of another 34 full-term infants,who were the controls,were measured periodically for six months at the same time points after birth.The data were analyzed statistically by independent samples t test, paired t test, ANOVA, Pearson correlation, linear regression and Mann-Whitney test. Results The mean values of monocular acuity (right and left) for the preterm infants were:2.48±0.02 and 2.49±0.02(2 weeks after birth),2.70±0.01 and 2.70±0.01 (gestational age,38 weeks),3.54±0.03 and 3.51±0.03 (14 weeks after birth),3.70±0.03 and 3.69±0.03 (gestational age,52 weeks),3.98±0.03 and 3.95±0.03(6 months after birth),4.10±0.02 and 4.09±0.02 (gestational age,63 weeks).There were positive correlation between visual acuity and months in the preterm infants [r=0.928,P<0.01; (Y)=0.248X+2.457 (R2=0.861,F=1769.743,P<0.01)].Also between visual acuity and weeks of gestational age [r=0.725,P<0.01; (Y)=0.017X+1.457 (R2=0.261,F=11.743,P<0.01)].Nor the weight or gender.The mean values of binocular acuity for the preterm infants at corresponding time points were 2.51±0.02,2.70±0.01,3.55±0.03,3.69±0.03,3.96±0.03,4.18±0.02.Mean values of monocular acuity for the full-term infants were 2.60±0.02 and 2.63±0.02 (2 weeks after birth),3.71±0.02 and 3.72±0.02(3 months after birth),4.06±0.02,and 4.05±0.02 (6 months after birth).There was no statistically significant difference between the two eyes. The binocular acuities of the full-term infants at corresponding time points were 2.60±0.02,3.72±0.02,4.14±0.02.Within the same age group, the acuities of the preterm infants was lower than those of the full-term infants (t=0.81,0.79,0.87,P<0.05). Conclusion The grating acuities of the preterm infants are lower than those of full-term infants.Visual acuity of the preterm infant progressively increases with age and improves at a faster rate during 1 to 5 months after birth.There is no corr elation between visual acuity and gender.This study shows that the early measurement of visual acuity in preterm infants is necessary even if no retinopathy of premature is present.The COPL system is useful for assessing grating acuity in infants.

Key words:
Premature;  Optometry,grating;  Visual development;  Preferential looking


sfTic J U L w a o LBL Lawrence Berkeley Laboratory UNIVERSITY OF CALIFORNIA m ^J Invited lecture presented at the Seminar on High Energy Nuclear Interactions and Properties of Dense Nuclear Matter, Hakone, Japan, July 7-ll, 1980 PION CONDENSATION AND INSTABILITIES: CURRENT THEOR> AND EXPERIMENT Miklos Gyulassy May 1980 Prepared for the U.S. Department of Energy under Contract W-7405-ENG-48 BISTfliaUTIBK OF THIS ODCUMCNT 13 UKUHIIT:


GENTLEMEN, -The case of the man whom you saw on Thursday in Richmond ward, and whose brain is now before us, has proved to be of unusual interest. At first sight, it appears to contradict some of the conclusions which I have ventured to state in previous lectures. The ma1, to whom I refer, was brought in on Tuesday evening at six c'clock. He had fallen into a ship's hold. He was bleeding from his left ear, and a small portion of brain-substance lay in the meatus. There was therefore no doubt as to his having sustained a fracture of the base of the skull, and that the fracture implicated his left petrous bone. He


ABSTRACT: This paper represents our summary interpretation of this symposium and provides our own suggestions as to cause and therapeutic approaches that could modulate the cerebrovascular and CSF dynamics that might reverse the pathology of Alzheimer's dementia.


The steady axially symmetric incompressible flow past a sphere is investigated for Reynolds numbers, based on the sphere diameter, in the range 0·1 to 40. The formulation is a semi-analytical one whereby the flow variables are expanded as series of Legendre functions, hence reducing the equations of motion to ordinary differential equations. The ordinary differential equations are solved by numerical methods. Only a finite number of these equations can be solved, corresponding to an approximation obtained by truncating the Legendre series at some stage. More terms of the series are required as R increases and the present calculations were terminated at R = 40. The calculated drag coefficient is compared with the results of previous investigations and with experimental data. The Reynolds number at which separation first occurs is estimated as 20·5.


This paper examines the main characteristics of the consular regime of social control of markets by looking at some aspects of the organization and operation of the Commercial Court of Paris, a four and a half century old institution in which judges are lay, business people. Comparing the pragmatic legal reasoning of the consular judges with Richard Posner's « experiential pragmatism » or « everyday pragmatism » points to a combination of old forms of institutional capture and new forms of corporatism that increasingly serve as a model for the management of core State functions. This raises the issue of finding news forms of protection of the public interest in a market society.


This paper advocated some constructive suggestions about lab-opening.These suggestions are as follows: up-dating of concepts,adjustment of thoughts,making clear goals of local college lab-opening;renewal of equipment,adding hardwares,meeting college students'needs of open-time and space;reformation of repetitious function,suppl-ying advantage service with more characteristic;innovation of organization forms of lab-opening,launching colourful theme-activities;innovation of resources distribution,strengthening the construction of characteristic resources,focusing on the construction of characteristic culture,supplying more individual service;establishment and improvement of man-agement system,supplying guarantee for lab-opening.


Water is essential to good health and economic progress, yet its provision to most urban residents in the developing world is still an unattainable goal. Indiscriminate exploitation of ground water for agricultural and industrial purpose has further aggravated the situation, affecting the quality and quantity of ground water. In Gwalior city the scarcity of drinking water occurred mostly in every summer. Due to excessive dose of iron, manganese, chloride, sulphates, total dissolved solids, hardness, alkalinity or acidity.  Physico-chemical parameters of ground water of municipal area of Gwalior city was carried out seasonally to study the quality of water and suitability for domestic purpose. Water samples from different sources at different locations were collected in different seasons. Following parameters were monitored & analysed by APHA (pH, Electric conductivity, TDS, Turbidity, Total hardness and Content of Fluoride, Sulphate, Chloride etc.) and results were compared with the standard values prescribed by WHO and APHA. The present investigation revealed that the quality of water of a source varies from season to season and some of the water samples are unfit for drinking and utility purpose. The status of drinking water in selected sampling sites is worst, distorted ecological equilibrium and urgent requirement to emphasize an eco-friendly technique. The main aim of this study is to assess the ground water and surface water quality status of selected sites of Gwalior region.


Meta data facilitates managing, querying, and understanding of data. The generation, storage, and management of meta data promises to minimize the efforts required for administration and to better support the exploitation of information systems.


Abstract The 1988 evaluation of A=70 (87Bh01) has been revised using experimental decay and reaction data received by the cutoff date noted below.


This paper introduces a full simulation and design of a photovoltaic power generation system to supply Al-Mahmoudia hospital in Baghdad/Iraq. The design steps include; daily average load estimation, annual solar irradiance and temperature monitoring and logging. PV panel selection and datasheet study to design the PV array and decide the number and connection method for these panels. (DC-to-DC) boost converter is designed. Then design and simulate a new type of (MPPT) controller based on mixed technique of artificial neural networks (ANN) with fuzzy Logic Controller (FLC) or (neuro-fuzzy) technique. The power generated from photovoltaic (PV) panels rely on the sun radiation and the ambient temperature. For this reason, the use of (MPPT) controller is a necessity to get as much as possible of the photovoltaic power from the system despite of variation in climatic conditions. The most famous method used for (MPPT) control is the Perturb and Observe (P&O) algorithm. Despite of the simplicity of this method, it is suffering from many problems including the oscillation around the (MPP), delay in system response and the maximum overshoot especially when the perturbation step size is large. The proposed (neuro-fuzzy) controller has been designed to get rid of the drawbacks of the classical (MPPT) methods including the P&O method. MATLAB/Simulink software has been used to design a photovoltaic module and array to supply the load of the hospital with 459kW. In addition the (DC-to-DC) boost converter and (MPPT) neuro-fuzzy controller are modeled. The performance has been compared between the proposed controller with the classical P&O and fuzzy logic controllers. The simulation results illustrated an enhanced performance in terms of oscillation, the response time, power harvesting and highest power overshoot


At a company's request we were asked to determine the placement and the number of protection devices for their electrical tree networks. Three location heuristics were selected for this purpose and tested on artificial data. The chosen heuristic was then applied to two real tree networks with successful results.


A new form of the dispersion relation of electron cyclotron waves in hot plasmas is used for the study of auxiliary heating in the Compact Ignition Tokamak (CIT). It is shown that the extraordinary mode with a frequency of 190 GHz can be used in CIT plasmas with a central electron density of 1×10−15 cm−3 and a toroidal magnetic field of 105 kG.


The end was almost anticlimatic after a tense night and day oC threats by Robert Rivers, 24, and Raymond Farra, 25, to harm ond even kill if necessary the three women and 16 male hos· tages unless penitentiary o[ficials gave them their freedom. The state, to secure the safe release of the captives, agreed to transfer Rivera and Farra to the David on County jail here "un· harmed, unmolested and unhar· assed" and lei them remain there until the courls can act on their petitions for writs of habeas cor· pu . As wailing relatives, who had kept an all·night vigil, clapped and pressed forward, the hostages began to emerge into the prison courtyard Cram the deputy war· den's office where they had been confined. First came six prison inmates, who had been held by the two rebellious convicts. Their hands were high above their heads. A few moments passed and 10 more men emerged in a group. By DAROLD POWERS Steff Writer


The state-of-the-art on the study results of dynamic properties of RC columns strengthened with FRP at home and abroad in three aspects including experiments,theory and construction technique is presented and the defects in current research are analyzed.Finally,several key issues in the future are discussed.


type="graphical" xml:id="gpol12124-abs-0002"> There is considerable cross-fertilization of ideas and continued cooperation and involvement with ombudsman practitioners "to share experiences and learn from best practices".


The peasant's employment out of agriculture must have influence upon the production of agriculture.The improvement of agricultural production technology can impel the agriculture modernization advancement effectively.This article takes both of the two facets above into consideration.By use of the sectional data which is from the investigation to farm households,this article analyzed the effect of the labors employment out of agriculture to the agricultural production technology adoption in a farm household,then explained the significance of peasant's employment out of agriculture through the conclusion of this study.


Work-related musculoskeletal disorders are a common problem in farming. The Austrian market offers different keeping systems to piglet farmers. Farmers should be able to easily and comfortably operate these systems. Therefore this study was carried out to determine discomfort and workload of existing keeping systems for farmers, and to identify possibilities of design improvements. The working postures of farmers were recorded with a digital video technique over 56 days. The video films were analysed as regards certain task elements by observers, and 448 postures were encoded, using the OWAKO Working Posture Analysing System (OWAS). The physically strenuous work processes occurred during feeding, mucking, and some special tasks. Discomfort and workload differences existed between the pens and crates, and further minor differences within these two groups. Overall, improvements can be achieved by using auxiliary handling devices, design changes of system components or other tools and the environment.


Due to a large number of components, complex meshing relations and high requirements for assembly accuracy, the dynamic characteristic of compound planetary gear, such as vibration, impact, periodic motion and load sharing, are more easily affected by internal excitation than those of simple planetary gear set and parallel shafting gear set. To improve the load sharing behavior and the resistance of Chaos motions in the compound planetary gear set, in this work, by introducing the floating support into the center gear and planet gear, a lumpedparameter dynamic model of the compound planetary gear set is built based on the lumped parameter method and Lagrange kinematics equation. The steady response is calculated by numeric method to investigate the influence of floating support from different components on loading sharing behavior and periodic motion. The results indicate that, the increase of the floating value of all components improves the instantaneous load-sharing behavior, and single floating of planet gear reduces the load sharing behavior. To avoid the system being in quasi-periodic motion and Chaos motions under the condition of floating support, the input speed should be avoided away from the range of 3201 r/min-5069 r/min.


Sixty-four sexual minority women (22 femme, 21 butch, and 21 who identified as both or neither) were asked open-ended questions about butch and femme. The sample ranged from those who considered butch/femme to be core aspects of their identity to those who found the terms meaningless or outdated. Many women mentioned appearance and/or masculinity/femininity when describing butch and femme. Women were equally divided about whether butch/femme was important to them, and also whether or not it was related to sexual activity. Few women divided housework or childcare according to butch/femme roles. Participants often stated that bisexual women were likely to be femme, yet few bisexual women in this sample identified as either butch or femme. Concepts of butch (or 'stud') and femme were perceived as more common in the African American and Latina communities and less so in Native American communities.


The diploma paper deals with the cost management of the material preparation division that is a part of the enterprise of Barum Continental spol. s r. o. The theoretical part descri-bes not only the processes and methods for the costs management and costs planning but also for the machinery equipment output management. The practical part deals, after a brief introduction of the company, with the analysis of the current cost management. The project part tries to suggest a convenient system for the cost management whose part is also the optimizing of the production equipmet effectivity that will lead to a cost saving.


The supercritical carbon dioxide (S-CO 2) Brayton cycle has been gaining interest in recent years due to its high efficiency and compact components. Bechtel Marine Propulsion Corporation (BMPC) is testing an S-CO 2 Brayton system at the Bettis Atomic Power Laboratory. The Integrated System Test (IST) is a two shaft recuperated closed Brayton cycle with a variable speed turbine driven compressor and a constant speed turbine driven generator using S-CO 2 as the working fluid designed to output 100 kWe. This paper presents practical aspects of S-CO 2 Brayton cycle operation including loop purge and fill operations and system leakage as well as design considerations including thermal stresses, material quality and loop cleanliness, and instrumentation. Additionally, operational test data for CO 2 temperature, pressure, and density are presented and comparisons made on the ability to accurately calculate CO 2 density using REFPROP for an operating Brayton loop.


The study investigated the effectiveness of programme learnning material over traditional teaching method of X class students in teaching physics. The main objectives of the researcher is to develop programme learning material for teaching physics to the students of X std and also compare the effectiveness of programmed learning material and traditional method on the achievement of students. In the study total 60 students participated. The researcher selected the two groups randomly where each one was composed of 30 students & were labelled as experimental group & Control group .Students in the experimental group was subjected to treatment using programme learning material respectively while students in the control group were taught using the traditional method of teaching. The researcheradministered pre test and post test in both the groups before teaching commenced and after the teaching. The mean of post test of control group is 25.03 and standard deviation is 3.48. The mean of post test of experimental group is 32.27 and standard deviation is 4.11 and the t value is 7.59. The study reveals that students learned with programme learning material performed better than the students taught with traditional method. Result revealed a statistical significant effect of programme learning material over traditional teaching method on academic achievement of students. Key words: Programme learning material, traditional method, physics Policy


PURPOSE: An improved method is provided to form an Arsenic Silicon Glass(ASG) film on a silicon structure by an LPCVD. CONSTITUTION: A method for forming an ASG film on a semiconductor wafer comprises: step for supplying a perpendicular high temperature LPCVD reactor containing a process chamber having a perpendicular boat storing plural wafers; step for supplying a first state including a tetraethylorthosilicate(TEOS) gas flowing from the lower unit of the chamber toward the upper unit; step for supplying a second state including a triethylarsenate(TEASAT) gas flowing from the lower unit of the chamber toward the upper unit; and step for supplying a third state including an oxygen(O2) flowing from the lower unit of the chamber toward the upper unit. Then, a non-interactive co-pyrolysis takes place between the TEOS and the TEASAT according to the existence of the O2 for a concordant deposit of the ASG film on the wafer to have an advanced thickness and evenness of an arsenic density in the same wafer or between the wafers of a lot.


This paper analyses the nature of university and living-arrangement decisions at the example of Dutch students with a secondary education academic diploma. A random utility maximization nested logit model of living-arrangement and university decisions is estimated, allowing for distance and rent e¤ects to vary according to the decision on whether to stay at parental home. Estimation results show that distance deters both at-homers and out-homers. Dutch youngsters are guided by consumption motives, rather than investment motives. They appear to attend university where their high school mates do. Tight housing markets lower the probability of choosing a given university. Male and low income students stay longer with parents, as do those with non-Dutch parents.


Fifteen patients with New York Heart Association Class IV functional cardiac disability whose mild-to-moderately severe renal failure had produced life-threatening fluid overload underwent dialytic therapy. Ten were dialyzed by the peritoneal route initially and five were switched from hemodialysis to peritoneal dialysis because of hemodynamic instability. All patients improved, resulting in renewed responsiveness to more conservative measures (2), stabilization for cardiac surgery (4), or less-restricted lifestyle out of hospital (9). We recommend consideration of peritoneal dialysis when biventricular and renal failure are refractory to conventional therapy.