Based on recent research work in our laboratory,effects of maternal nutrition on progeny carcass quality and the mechanism of progeny compensation in pigs were analyzed.Influences of low maternal nutrition level during pregnancy and lactation on growth performance,organ development,and meat quality for different stages of offspring were expounded to testify whether the maternal nutritional effects and compensatory growth effects existed in the offspring followed-up growth process.Meanwhile,the influence of low maternal nutrition on progeny blood biochemical indicators,hormone level and gene expression were observed in these experiments.Metabolic and molecular mechanism of the maternal effects on progeny growth performance and meat quality traits were analyzed and discussed in this article as new measures for meat quality improvement in pigs.


Luciano et al. generate transgenic mice expressing the Bcl-B gene under the control of the VH promoter and Eµ enhancer and show that these mice recapitulate the characteristic features of human MM.


Financial performances can show the ficture of successful form of enterprise value for both present and future time. Financial performance can be achieved optimally by the implementation of good corporate governance. Reformation of integrated information systems covering budgeting system, information system, auditing and institutional reformation will yield clean governance. And accountancy will consequently show its maximum role. The purposes of this research is to analyze and learn (1) Correlation of the external and internal auditor, (2) the influence of the external and internal auditor to the implementation of good corporate governance. Research method was descriptive and verificative analyses. The conclusions of the research are as follow (1) a significant correlation of the external and internal auditor, (2) external and internal auditor can influence to implementation of good corporate governance.


The study was conducted in response to the problem on how to develop a practice structure that will promote learning in Table Tennis Physical Education classes even with limited time and inadequate facilities which is a common fixture in Philippine setting. In the present study, the participants (n= 32) were randomly assigned to either one of two subject groups. The experimental group (n= 16) performed the shadow practice while waiting for their turn to practice with multi-balls. The control group (n= 16) practiced with a single ball for each pair of students while waiting for their turn to practice with multi-balls. The commonly used consistency and accuracy skills test was used to determine their pre-test, post-test and retention test scores. The level of significance was at P = .05. Using descriptive measures, the data revealed that both groups showed a significant change in the scores in the post-test phase of testing. The experimental group's mean = 83.5 while this group's pre and post test t = -14.3226. The control group's mean = 81.7 while this group's pre and post test t = -16.02311. However, only the experimental group was able to retain their scores in the retention test phase of testing. The experimental group's mean = 83.4 while this group's post and retention test t = 0.04897. The control group's mean = 78.3 while this group's post and retention test t = 4.6929529.


A semiconductor device comprising: a semiconductor substrate; a plurality of formed on the semiconductor substrate semiconductor elements (M11, M12, M13); and a Grabenisolationsoxidfilm (BT1, BT1A, BT2, BT3) obtained by burying an oxide film (OX11, OX13) in a trench (TR1, TR2) is obtained, which is formed in the surface of the semiconductor substrate to the plurality of semiconductor elements (M11 , M12, M13) electrically isolate using the Grabenisolationsoxidfilms, wherein the Grabenisolationsoxidfilm having on the left and right edges of different outline shapes at the upper edge region in a transverse section of the Grabenisolationsoxidfilms and contains, in combination: a full grave structure which reaches the buried oxide film (2) by an SOI layer (3) therethrough; and a partial grave structure having the SOI layer (3) at its lower portion.


A novel edge detection algorithm is presented in this paper. The proposed method is based on the neighborhood similarity of a pixel using a pre-defined intensity range and median filter which can be implemented easily and effectively. Many experiments were carried out to evaluate and compare the performance of the proposed algorithm. This new detector outperforms the previously available classical edge detectors.


The utility model provides a test sample fixture for an autoclave, wherein the fixture comprises a support (5) and a fixed part (6); the support (5) is provided with a first columnar part (7) and a rod part (8) extending outward from external circumference of the first columnar part (7); the middle of the first columnar part (7) is provided with a first mounting hole (9) along the axial direction; the fixed part (6) is provided with a second columnar part (10) and mounting parts (11a and 11b) extending outward from external circumference of the second columnar part (10); the middle of the second columnar part (10) is provided with a second mounting hole (12) along the axial direction; and the second columnar part (10) is fixedly sheathed on the rod part (8) in a dismountable manner through the second mounting hole (12), so that the position of the mounting parts (11a and 11b) is adjustable. The test sample fixture can well simulate oil corrosion in the actual production environment.


In this paper, the spatial patterns of different land use types in Zhengzhou urban area were analyzed at landscape level and class level, based on the relevant maps interpreted by high resolution QuickBird imagery in August 2005 and with the aid of GIS software ArcView and landscape pattern analysis software Fragstats. The results showed that greenbelt had the largest area, occupying 35.51%, while unused land had the smallest one, accounting for 0.33% of the total. Spatially, greenbelt was round in shape and with small and fragmental patches, residential and industrial lands were rectangle, and road system was grid-shaped. There was an evident difference in the horizontal distribution of the landscape patterns. The landscape heterogeneity was the largest in the southwest, greenbelt was more in the east than in the west, and the whole urban landscape was characterized by large patches.


The Purpose of this internship was to Integrate the sensor suite which will be mounted onto a robotic inspection tool used to survey the H-Canyon Air Exhaust (CAEX) tunnel the Savannah River Site. This sensor suite incorporates 3D-mapping of its surroundings, along with a 360 degree picture of its surroundings stitched in with the li-dar readings. Incorporation of the IMU would enable us to track the position of the robot inside the cave, such that the robot handlers can know where inside the exhaust tunnel the scans have been taken. The Inertial Measurement Unit (IMU) used had ROS compatibility, allowing for high leavel programming and ease of software modification. The sensor transmitted Data in the form of Acceleration. A good portion of the internship concerned the investigation of discrete integration techniques, such that we can acquire precise position information quickly.


An electric compressor (1) for compressing a gas, in particular for a motor vehicle, comprising a control unit (2), an electric motor (3), wherein the electric motor (3) by means of the control unit (2) is controllable, a compressor (4), wherein the compressor (4) and the electric motor (3) coaxially on a shaft (5) are arranged and the compressor (4) by means of the electric motor (3) can be driven, and a housing (6), wherein the housing (6) at least partially enclosing the electric motor (3) and the housing (6) is made by means of a Vergussverfahrens such that one piece with the housing (6) is formed at least one first bearing (26) for receiving at least a first shaft bearing (11), wherein in the region between the first bearing point (26) and an outer periphery (23) of the first shaft bearing (11) at least one elastic element (25) is arranged and a method of manufacturing such an electric compressor (1).


We obtain new uniform asymptotic formulae for the second moments of -series of cusp forms of even weight with respect to the congruence subgroup .


Solid oxide fuel cells (SOFCs) are considered as environmentally friendly and sustainable energy conversion devices due to their high conversion efficiency and fuel flexibility. They usually operate in the high temperature regime of 700-10000C, which poses practical problems such as thermal stress or rapid material degradation [1]. Therefore, extensive research has been done towards lowering the operating temperature. However, this significantly increases the activation loss, especially at the cathode side, because of the sluggish oxygen reduction reaction (ORR). There have been many efforts to reduce the activation loss at the cathode side in lowtemperature SOFC (LT-SOFC), one of which is to use an interlayer such as doped ceria, i.e. gadoliniadoped ceria (GDC) or yttria-doped ceria (YDC) [2].


This paper describes estimations of the shape of a three-dimensional (3-D) object from a gray-level 2-D image, i.e., "shape from shading." The fact that the Ikeuchi-Horn iterative method produces an error when this is applied to the estimation of an object having a concave surface is shown. A new method using a constraint on a zero-crossing is proposed which can be applied to such an object. Examples of application of the proposed method are shown to confirm its effectiveness, from a case where several interpretations are possible from a single gray-level 2-D image, the proposed method can estimate all of them. Examples of such cases also are shown.


Variations in body fat (BF) among pigs can be associated with differences in insulin sensitivity given the insulin anabolic effect in lipid synthesis. The study objectives were to characterize this association and compare the relative mRNA abundance of genes associated with insulin resistance and de novo lipogenesis in the adipose tissue of fat and lean pigs. Thirty 95 kg pigs, catheterized in the jugular vein, received an oral dose of 1.75 g glucose/kg of BW after 18 hours of fasting. Blood samples were collected at -20, -10, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 150, 180, 210, 240, 300 and 360 minutes following glucose ingestion. Insulin sensitivity indexes were calculated and analyzed. The BF (%) was estimated by dual X-ray densitometry. The 8 fattest (22 % BF) and the 8 leanest pigs (17.2 % BF) were used to determine the relative mRNA abundance of studied genes using real-time qPCR analyses. Insulin sensitivity was determined using QUICKI and Matsuda indexes, respectively, and their association with body fat was studied with Spearman correlations. Differences in gene expression and insulin sensitivity between fat and lean pigs were studied with a one-way ANOVA. The QUICKI and Matsuda indexes negatively correlated with BF (r = -0.67 and r = -0.59; P < 0.001). Fat pigs had reduced insulin sensitivity and higher relative mRNA abundance of lipogenic enzymes (ACACA, ACLY, FASN; P < 0.05) than lean pigs. The higher expression level of glucose-6-phosphate dehydrogenase (G6PD) combined with the trend (P < 0.10) of lower expression of peroxisome proliferator-activated receptor-gamma (PPAR-γ) in fat pigs may explain part of their reduced insulin sensitivity. These results suggest that an increased BF is associated with reduced insulin sensitivity and greater expression of lipogenic enzymes in pig adipose tissue.


Malignant prolactinomas are extremely rare (1, 2). The diagnosis of these carcinomas is mainly based on the patient's medical history and the detection of metastases. Nuclear medicine offers new imaging modalities for the detection of metastases of pituitary carcinomas. These techniques may have serious consequences for subsequent investigations and therapy. The case presented here shows the clinical behavior of a malignant prolactinoma. The usefulness of dopamine D2 receptor scintigraphy for establishing the diagnosis and subsequently directing the therapeutic approach is illustrated.


The detonation parameters can be calculated using different methods with satisfying accuracy. Different approaches of detonation parameters' calculations are used in many fields of engineering practice. The calculation results of detonation parameters using semi-empirical method and thermochemical model of detonation are presented in this paper. Both methods are applicable for CHNO high explosives, and with some approximations for CHNOAl high explosives. The calculated values using semi-empirical method have significantly better accuracy compared with the well-known Kamlet's method. The thermochemical model uses BKW equation of state with different sets of parameters. The detonation products are calculated using the free-energy minimization criterion. The computer program XW is developed, which is using both methods. The XW is developed using the Delphy ® 6.0, and it can be used on personal computers with operating system WindowsXP ® . The analyzed XW calculation results of detonation parameters have good correlation with experimental data. Using the semi-empirical method, obtained average differences of calculation results for considered high explosives were 1.9% for detonation velocity and 4.5% for detonation pressure. In the calculations using thermochemical model, average differences of calculation results were 2.05% for detonation velocity and 5.73% for detonation pressure. In the case of most used high explosives for military purposes, the precision of calculation results is even higher. * Assistant Professor, Department of Military Chemical Engineering, Military Academy, Pavla Jurišića – Šturma Street 33, Belgrade, Serbia, firstname.lastname@example.com † Professor, Military Academy, Pavla Jurišića – Šturma Street 33, Belgrade, Serbia, email@example.com ‡ Assistant Professor, Department of Military Chemical Engineering, Military Academy, Pavla Jurišića – Šturma Street 33, Belgrade, Serbia, email@example.com § Professor, Military Academy, Pavla Jurišića – Šturma Street 33, Belgrade, Serbia ¶ Assistant Professor, Department of Military Chemical Engineering, Military Academy, Pavla Jurišića – Šturma Street 33, Belgrade, Serbia, email@example.com Proceeding of the 6 th ICEE Conference 29-31 May 2012 ENMA-3 2/7 2/7 Introduction In many aspects, the detonation parameters are the most important characteristics of high explosives. The most important detonation parameters are detonation velocity D and detonation pressure p. There are many methods successfully developed for detonation characterization of high explosives, and many experimental values are widely published. But, in many cases it is very difficult to experimentally determine these values. Many authors have managed to develop models for D and p calculations. There are many models based on semi-empirical approach [1, 2, 3]. Such models are based on simplified view on detonation process, but have surprisingly very high precision of calculation results for CHNO high explosives with initial densities within certain range. For example, the Kamlet's method has been often used for calculations of detonation parameters in the past decades [1]. The thermochemical approach in modeling of detonation is one of several ways to calculate detonation parameters with more detailed view on the process itself. The approach is based on simplified thermochemical view of chemical reactions during detonation process. The chemical decomposition of energetic material is considered as their very fast transformation into detonation products, with conservation of mass and energy. Many aspects are not necessarily considered, such as reaction kinetics, time scale etc. Despite that, such models show good correlation with experimental data and can be used for detonation modeling of the most military high explosives. Such models of detonation are presented in [4, 5, 6]. Computer program XW was developed based on the previously described approaches in modeling of detonation, both semi empirical and thermochemical. XW is used on personal computers with operating system WindowsXP ® . The semi-empirical model [3] is based on the fact that the experimental values of the detonation parameters are proportional to the initial density of the explosive [1]. Experiments show that detonation velocity has linear dependence on initial density for all explosive charges above a critical diameter. Based on the equation of state (EOS) for gases, the pressure is proportional to the number of moles of gaseous detonation products n. Therefore, it is assumed that detonation pressure is proportional to the square of initial density ρ0. In this model, detonation velocity and detonation pressure are calculated using the following equations: nQ D 0 7072 . 7 1 . 2264    (1)


A trispecific killer engager (T riKE) molecule containing an anti-cluster of differentiation 16 (CD16; FcgammaRIII) single-chain variable fragment (scFv) to engage natural killer (NK) cells, an anti-CD33 scFv to engage myeloid cells and a human modified interleukin-15 (IL15) linker, that links the two scFv, with potential immunomodulating and antineoplastic activities against CD33-expressing tumor cells. Upon administration of the CD16/IL15/CD33 T riKE, the simultaneous binding to CD16 on NK cells and CD33 on tumor cells will induce NK cell cytotoxicity specifically against CD33-expressing tumor cells. T he cytokine IL-15 linker promotes NK cell proliferation, activity, survival and expansion. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. Qeios · Definition, February 2, 2020


The automatic classification of bird sounds is an ongoing research topic and several results have been reported for the classification of selected bird species. In this contribution we use an artificial neural network fed with pre-computed sound features to study the robustness of bird sound classification. We investigate in detail if and how classification results are dependent on the number of species and the selection of species in the subsets presented to the classifier. In more detail, a bag-of-birds approach is employed to randomly create balanced subsets of sounds from different species for repeated classification runs. The number of species present in each subset is varied between 10 and 300, randomly drawing sounds of species from a dataset of 659 bird species taken from Xeno-Canto database. We observe that the shallow artificial neural network trained on pre-computed sound features is able to classify the bird sounds relatively well. The classification performance is evaluated using several common measures such as precision, recall, accuracy, mean average precision and area under the receiver operator characteristics curve. All of these measures indicate a decrease in classification success as the number of species present in the subsets is increased. We analyze this dependence in detail and compare the computed results to an analytic explanation assuming dependencies for an idealized perfect classifier. Moreover, we observe that the classification performance depends on the individual composition of the subset and varies across 20 randomly drawn subsets.


In this study, Zr0.5Hf0.5O2 films were fabricated on Si substrate and were annealed at different temperatures by rapid thermal annealing (RTA) process. The charge trapping memory devices based on Zr0.5Hf0.5O2/SiO2/Si simple structure were investigated in detail. The memory device annealing at 690 °C shows the best property with a memory window of 5.6 V under ±12 V sweeping voltages in its capacitance-voltage curve and a better retention property. The high resolved transmission electron microscopy shows the generated SiO2 working as tunneling layer after RTA process, whose thickness increases with the rise of temperature. Combined with the TEM results, the photoluminescence spectrum and in situ angle resolved photoemission spectroscopy results further verify that oxygen vacancies and inter-diffusion layer also play a crucial role in charge trapping performance. This work provides direct insights for the charge trapping mechanisms based on high-k Zr0.5Hf0.5O2 films devices.


Abstract At Alcibiades I, 133b-c, the reader expects, but does not according to the MSS find, the return of the mirror-motif that had supposedly explained the true meaning of the Delphic injunction. Hence it remains unclear why anything viewed within the soul should act in any way that resembles a mirror. I argue that the substitution of a single letter in one word, about which the manuscripts and modern scholars in any case disagree, can restore the necessary reference to a reflective surface, though not specifically to a mirror, since the term for a mirror could only be applied to sight. A failure to understand the underlying intertextual allusion to Cratylus 408c had resulted in a safe but unsatisfactory substitution by Late Antiquity, and other modifications followed thereafter in an effort to give meaning to the text.


The article considers the influence of eastern patristics on the content of the notion «sobornost». Studying the works of St. Maximus the Confessor the author makes an attempt to trace the evolution of his religious philosophy through the main aspects: ontological, gnosiological, ethic, which are closely connected with theological problems.


We report two cases of patients with non ischemic dilated cardiomyopathy, wherein despite optimized medical therapy, they are symptomatic. Unlike other approaches in the cardiomyopathy therapy, we utilized only purified bone marrow mesenchymal cells instead of total bone marrow for them. Moreover, these purified bone marrow mesenchymal cells were infused instead of injected. Both patients responded well to stem cell infusion. There were improvements in echocardiographic parameters of cardiac function, which were highest after the third infusion. Decline in ejection fraction were noted after an infectious process. The first patient is currently alive (survived for at least 4 years from the time of infusion); while, the second patient succumbed to sepsis 9 months from the stem cell infusion.


Up to now, we often find data which have correlation between time and location. This data also known as spatial data. Inflation rate is one type of spatial data because it is not only related to the events of the previous time, but also has relevance to the other location or elsewhere. In this research, we do comparison between GSTAR model and GSTAR-Kalman Filter to get prediction which have small error rate. Kalman Filter is one estimator that estimates state changes due to noise from white noise. The final result shows that Kalman Filter is able to improve the GSTAR forecast result. This is shown through simulation results in the form of graphs and clarified with smaller RMSE values.


We exploit transient and permanent error control methods to address Hardware Trojan (HT) issues in Network-on-Chip (NoC) links. The use of hardware-efficient error control methods on NoC links has the potential to reduce the overall hardware cost for security protection, with respect to cryptographic-based rerouting algorithms. An error control coding method for transient errors is used to detect the HT-induced link errors. Regarding the faulty links as permanently failed interconnects, we propose to reshuffle the links and isolate the HT-controlled link wires. Rather than rerouting packets via alternative paths, the proposed method resumes the utilization of partially failed links to improve the bandwidth and the average latency of NoCs. Simulation results show that our method improves the average latency by up to 44.7% over the rerouting approach. The reduction on latency varies from 20% to 41% for three traffic patterns on a 5×5 mesh NoC. The impact of different HT locations on NoC links was examined, as well. Our method is not sensitive to HT locations and can improve the effective bandwidth by up to 29 bits per cycle with minor overhead.


The utilization of refractive index surfaces in conjunction with the Clemmow, Mullaly, Allis (CMA) diagram greatly simplifies the determination of the regions of Cerenkov radiation and the types of waves emitted in a cold, collisionless, electron magnetoplasma. Also, the physical insight gained by this approach is used to explain the qualitative behavior of the power spectrum.


Bitcoin has revolutionized digital currencies and its underlying blockchain has been successfully applied to other domains. To be verifiable by every participating peer, the blockchain maintains every transaction in a persistent, distributed, and tamper-proof log that every participant needs to replicate locally. While this constitutes the central innovation of blockchain technology and is thus a desired property, it can also be abused in ways that are harmful to the overall system. We show for Bitcoin that blockchains potentially provide multiple ways to store (malicious and illegal) content that, once stored, cannot be removed and is replicated by every participating user. We study the evolution of content storage in Bitcoin's blockchain, classify the stored content, and highlight implications of allowing the storage of arbitrary data in globally replicated blockchains.


A pulsed laser has been used to vaporize and ionize very small areas on the surface of materials that contain hydrogen. A thin foil scintillation detector has been used to examine the plasma that expands away from the interaction region. This device has high sensitivity for detecting hydrogen ions and very low sensitivity for heavy mass ions. Its use to determine hydrogen concentrations in materials at low level has been examined. It can also be used to determine energy distributions for hydrogen ions from mixed ion plasmas by the time‐of‐flight method.


The high-dielectric-constant (high-k) gadolinium oxide layer (Gd 2 O 3 ) and praseodymium oxide layer (Pr 2 O 3 ) are demonstrated as gate dielectric insulator materials in GaAs metal-oxide-semiconductor field-effect transistors (MOSFETs) using in situ high oxygen flow rate electron-beam deposition technology. The dielectric constants of the Gd 2 O 3 and Pr 2 O 3 layers developed in this study were 9.2 and 9.8, respectively. The Schottky gate turn-on voltages of GaAs MOSFETs with Gd 2 O 3 and Pr 2 O 3 insulators were 2.23 and 2.25 V, respectively, representing an improvement on the conventional p-type high electron mobility transistors (0.85 V). Moreover, the Gd 2 O 3 MOSFETs had a higher thermal stability and thermal linearity than the Pr 2 O 3 MOSFET (temperature range 100-400 K) due to its high binding energy, as revealed by X-ray photoelectron spectroscopy.


Background:  This aim of this study was to compare the prevalence of various disease‐associated and potentially modifiable risk factors between people with familial and sporadic forms of primary open angle glaucoma (OAG).


In this article, we perform a thematic analysis of a sample of 70 #ButNotMaternity Instagram posts. #ButNotMaternity is a hashtag that emerged in the United Kingdom during the COVID-19 pandemic whereby the public, healthcare workers and campaigners shared experiences and concerns about pandemic maternity care restrictions and their disproportionate disadvantages for pregnant women. In the article, we analyse four themes that emerged from our thematic analysis – Individual experiences, loneliness and overcoming adversity, Voicing anger and absurdity, Mobilising anger and calls to action and Coordinated activism. Thinking about #ButNotMaternity in the context of 'freelance feminism', our article has a twofold aim. First, we explore the concept of 'freelance feminism' through #ButNotMaternity, asking to what extent this campaign draws from freelance tactics. Second, we use the hashtag to illuminate maternity inequality and modes of resistance during the COVID-19 pandemic. Through our thematic analysis, we argue that while 'freelance feminism' might be becoming hegemonic as a dominant mode of organising feminist activism and resistance, inspired by Malik et al. (2020), we also showcase how creative campaigns are potential places where collective action, structural critique and resistance may emerge.


Abstract The goal of opening up foreign product and financial markets is now pursued with the same missionary zeal that fighting Communism once was, and with similarly uplifting rhetoric about democracy.


Aiming at the present situation of printing information management, a MIS is developed in order to share and make use of information of printing enterprises. The system uses strategy of the up-to-down based on Visual C++ 6.0, SQL Server 2000 database technology, and Client/Server network construction. The development process of the system is introduced. Six main functions are realized, including function of user management, input, query, statistic, maintenance, report forms printing.


Denoising processing of precipitation series was based on the wavelet denoising technology.A Trous algorithm of wavelet transform was used to decompose the signal,the sequence of each wavelet coefficient was used to take the cross-correlation analysis,a stochastic model that correspond with the sequence of wavelet coefficient was established,finally wavelet random coupling model was obtained by wavelet reconstruction algorithm.According to the precipitation data of crop growth period of Chahayang Farm From 1956 to 2008,the article established the wavelet random coupling model and test it's accuracy.The results indicat that the accuracy of prediction and fitting of the model is high,the model can reflect the rules of precipitation in the region.


The Arab-Israeli peace process, a U.S. led diplomatic effort, has been unfolding over nearly four decades. Various American policies, ranging from a step by step approach to securing a comprehensive settlement, reached their peak in the 1990s, with the Clinton administration's sustained efforts to settle the Arab-Israeli dispute. Although these efforts yielded several successful outcomes, including mutual recognition between Israel and the Palestinian national movement and greater Arab-Israeli normalization, they were marred by the continuous Israeli-Palestinian strife and other negative developments. Much of these efforts were promoted by professional experts, working for various branches of the U.S. government. This article surveys several books written by some of these officials, which provide diverse accounts of the unfolding events. The testimonies in these books range from comprehensive surveys to attempts at exploring the reasons for America's failed venture, and offer new insights into the peace process.


The modernized distance education should be a kind of education based on dialogue.The dialogic distance education mode aims at highlighting man's subjectivity and values,and emphasizing the individual's autonomous cultivation of reflection.Its essential principles consist in the equality and harmony,the individuality and difference,the openness and in-depth.Its basic strategies contain creating a situation of free dialogue,training man's questioning consciousness,encouraging man's own expressions,thus constructing the open discourse mode.


The goal in studies concerning biomarkers in autoimmune diseases is finding a marker which fluctuates in correlation with the disease's severity and settles within normal borders after effective treatment. This marker would later be used as an efficient tool in diagnosis and analysis of medicine clout. It seems the most cogent biomarkers are those measurable in serum or plasma. MS is a neurological disease common within the young adult population with a predictable course, often leading to life-immersing disability. The prognosis, however difficult and limited, is currently possible via diagnostic tests (brain MRI) or clinical information (severity and degrees of disability). Many studies have been conducted in an effort to detect an adequate biomarker. It is still often overlooked that a reliable biomarker should both be clinically applicable and functional is prognosis; as this is what could lead to timely treatment. Conflicts of Interest: Declared None Funding: None


Large multidimensional arrays are extensively used as the basic data structure in scientific, statistical and engineering applications. Increasing size of Data warehouses and high degree of sparsity makes demand for developing some compression schemes in order to obtain better performance. In this paper, we propose a new compression scheme namely Linearized Extendible array based Compressed Row Storage (LEaCRS) scheme for large multidimensional sparse array. The main idea of this scheme is to linearize each sub array found from the existing extendible array and then compresses the sub arrays independently using the CRS method.


The relevance of the article is determined by the fact that at present the majority of governmental HR departments have no precise career strategy for civil servants, which affects considerably the efficient functioning of the authorities. The author presents a model of the HR management, which can promote the career progress of the civil servants.


Surabaya Shipping Polytechnic emphasizes on certain areas of expertise that Taruna must possess. This is the basis after graduating from shipping polytechnics, cadets must have expertise and skills. The purpose of this study was to study the effect of inquiry, discovery learning, and creativity levels on the ability to write descriptive essays on nautical and technical cadets at Surabaya Shipping Polytechnic. This type of research is research. This research uses quantitative methods using experiments. The location used in this research is Surabaya Shipping Polytechnic. The subjects in this study were the cadets of the Nautika A, Nautika B, Teknika A, and Teknika B. classes. Based on the results of the research and discussion, the following conclusions are obtained: There are those that can be solved looking for description essays in the cadets. learning discovery method. The test results show better investigation methods than the discovery of learning, There is a difference in the ability to write a description essay about cadets who have a high level of creativity with cadets who have a low level of creativity, the test results show better who have a high level of creativity, there are related with learning methods and descriptions of the ability to write essay descriptions, the test results show learning methods and creativity descriptions of the ability to write essay descriptions.


In this study two new indexes that measure the upward and downward slopes of the QRS complex are proposed to quantify variations in the depolarization period due to induced ischemia during percutaneous transluminal coronary angioplasty. Our results show that QRS slopes turn out to be substantially less steep during artery occlusion, being this effect more manifested for the downward slope than for the upward one. Comparing the proposed indexes with a previously reported index that quantifies the energy of the high-frequency QRS signal (150-250 Hz), it is shown that the ability of the slope indexes for ischemia detection is clearly superior. When comparing with the conventional ST level, enhanced performance of the proposed indexes is only found in some leads. It can be concluded that diminution of QRS slopes can be used as an additional tool, alternative to HF-QRS content, to ST deviation when diagnosing ischemia


The paper describes the authors' approach to teaching electric power equipment CAD techniques to undergraduate students pursuing a degree course in Electrical Engineering. Details of one experiment undertaken by the students are given. The experiment focuses on the calculation of terminal inductances from numerical field solutions. The simulation tasks are easily adapted to the analysis of a greater varied of electrical equipment.


were highlighted by the Airway Device Evaluation Project Team (ADEPT) [3]. The manikin used in this study, whilst anatomically correct, is relatively easy to navigate with a fibrescope. Therefore, we believe it is not clear from this study if the handling of the aScope would be comparable in more difficult clinical situations. Indeed, ADEPT recommends that airway devices undergo trials to produce level 3b evidence before introduction into clinical use (i.e. a single, non-randomised, casecontrolled clinical study). Lastly, we would like to draw attention to provision of fibrescopes by the National Creutzfeldt-Jakob disease Surveillance Unit, Edinburgh, for cases of suspected vCJD, which is an alternative to single-use fibrescopes in this group of patients. We suggest that this interesting article demonstrated that anaesthetists are adept in learning to master new pieces of equipment, but the clinical applications of single-use fibrescopes remain unclear.


In the Finnish language there are three morphological cases that are available for the core arguments. The cases are the nominative, the genitive and the partitive. These three cases can indicate both the subject and the object. Then, we should clarify the relationship between the case marking and the syntactic status of the core arguments in the Finnish language. We should also examine to what extent the linearity plays an important role, since the Finnish language is often described as a free-word-order language. Although the default interpretation of a core argument is derived from its case marking, the word order also plays an important role in the Finnish syntax.


Serotonin (5-HT) receptors play an important role in the regulation of pituitary function. In particular, 5HT agonists stimulate ACTH, {beta}-endorphin, prolactin and growth hormone secretion but inhibit TSH release. 5-HT binding sites have been identified by autoradiographic studies of rat and human pituitary. In the present investigation, we used PET with F-18 setoperone to image 5-HT2 receptors in normal humans. Setoperone, a piperidine derivative with potent 5-HT2 receptor blocking properties was labelled with F-18 by nucleophilic substitution on the nitro derivative. After HPLC purification, specific activity was between 10,000 and 15,000 mCi/{mu} mole and radiochemical purity was >98%. Six healthy male volunteers were injected with 5-7 mCi of F-18. Setoperone and serial PET images and arterial blood samples were collected over 2 hrs. Specific binding to 5-HT2 receptors in the frontal cortex (FC), striatum (ST) and pituitary (P) was quantitated using the cerebellum (C) as reference. The tracer showed clear retention in FC, ST and P (known to contain a high density of 5-HT2 receptors) relative to C (known to be devoid of 5-HT2 receptors). In all subjects, FC/C, ST/C and P/C ratios increased during the first hr. and remained stable thereafter. For FC and ST, the ratios reached similarmore » values; 3.92{plus_minus}0.73 and 3.53{plus_minus}0.32. For pituitary, a significantly higher ratio, was measured at all times; 6.53{plus_minus}1.82 (p<0.01). These results indicate that F-18 setoperone is an effective PET radiopharmaceutical for imaging 5-HT2 receptors in the human pituitary. Future applications of this agent could provide important new insights into neuroendocrine function.« less


In recent years, with the continuous development of China's society and progress, the social requirements for Englishtalent has also been improved. English linguistics is a basic course for the students majoring in English Majors in Colleges and uni-versities. The aim of this course is to provide students with a systematic knowledge of English, so as to improve their learning abili-ty, stimulate students' interest in learning English and cultivate students' creative ability. Project learning is a new teaching meth-od, which is of great significance to improve students' English ability. Based on this, this paper explores how to apply the projectlearning to the teaching of English language teaching and improve the teaching quality.


Zircon SHRIMP U-Pb dating of Dachong granodoirite in Fozichong deposit,Guangxi province,is conducted in this paper,yielding an age of 258.2±3.2 Ma95% confidenceMSWD=0.59.The result shows Dachong stock intruded at shallow place in Hecynian,not late Yanshanian constrainted by former researchers.Compiled with regional metallogenic rule of "no Hecynian mineralization" and geological characteristics of this deposit,we support metallogenic granite is not Dachong granodoiritic stock,but Yanshanian granitic porphyry dike swarm.The Yanshanian granitic porphyry together with Pb,Zn mineralization,were obvious controlled by Niuwei fault system.


Cooperation between cities is significant to promote the economic development of a megalopolis .By comparing the economic condition and weighing the level of industrial division, the research suggests that Nanjing and Hangzhou can cooperate on infrastructures, division and environmental protection.


Objective: To reach the objective of quality control through determination on Rhodiola content of Rhodiola rosea dropping pills and its dissoluteion rate.Methods: The Rhodiola content of the dropping pills was determined by HPLC and its dissolution rate was determined by small glass method.(1) Determination of rhodiola content: use Chromarsil-C_(18) ODS column(250×4.6 mm,5 μm),fluid phase was 15% methanol,the detection was set at 285 nm,flow rate was 0.8 ml/min,column temperature was 35℃,injection amount was 10 μl.(2) Determination of dissolution rate: use RCZ-1A dissolution apparatus,solvent was 200 ml water,method was small glass method,rotation speed was 50 r/min.Results: The detection was set at 285 nm,the calibration cure is linear between 40.5~405 μg/ml,the average recovery rate was 100.37% with RSD 1.52% and its dissolution parameters obtained were T_d=4.30,T_(50)=3.03 respectively.Conclusions: This methods were convenient and fast,reliable,extract,its recurrence was fine.It can be the effective method of content and dissolution determination of Hongjingtian dropping pills.


IPM is acronym of intelligent power module,which is integrated with power transform circuit、driver circuit and protecting circuit. Using it can simplify peripheral circuit of the inverter,and save time for designing a transmitter greatly.But the setting of dead time is a very important issue when we use IPM.In electrical exploration,inductance of load,which influence t_(off) of IPM,is large sometimes.So,the dead time of a transmitter is needed to be long correspondingly.Meanwhile,it's necessary that the dead time can be changed in different transmitting frequencies.For instance,when we use long polar distances,the area inside transmitting wire is bigger than the short ones,and the inductance is larger,too.On the other hand,when we choose higher frequencies,shorter dead time is needed,otherwise there will be a serious distortion.Considering of above conditions and the convenience of hardware designing,the dead time should be set in some adjustable options.Different selection can be chosen according to different geophysical exploration methods and practical conditions.


Objective: To ascertain and identify risk determinants linked with and without dyslipidemia in type 2 diabetic patients.
 Study Design: Comparative cross-sectional study.
 Place and Duration of Study: Fauji Foundation Hospital and Military Hospital, Rawalpindi, Pakistan, from Jan 2018 to Jan 2019.
 Methodology: Total 90 subjects were divided into three groups; diabetes with dyslipidemia, diabetes without dyslipidemia and controls. Their blood sugar, lipid profile, HbA1c, hepatitis screening and anthropometric data were considered.
Results: Out of 90 patients, females and males were 73 (80.2%) and 17 (18.7%) respectively. Dyslipidemic females displayed higher LDL-C (3.29 ± 0.95) and lower HDL-C (0.74 ± 0.25) values, while males showed high total cholesterol (5.60 ± 1.30) and triglyceride (2.88 ± 1.40) levels. Female dyslipidemics and non-dyslipidemics exhibited highest HbA1c values (8.90 ± 2.25 and 7.81 ± 1.41). Female and male dyslipidemics displayed highest BMI measures (25.27 ± 3.44).
Conclusion: Significant associations were seen among type-2 diabetes mellitus subjects (with and without dyslipidemia) and age, gender, HbA1c, lipid profile, BMI and obesity.


ABSTRACT This paper examines the oral stories of Pacific people attending addiction treatment services in Auckland, New Zealand who were participating in a larger study exploring the validity of the Alcohol, Smoking and Substance Involvement Screening Test. (ASSIST). A Talanoa approach was used by interviewers to help gain an understanding of the factors associated with participants' substance misuse. Interviewers made notes of the stories they heard. Fifty participants were interviewed and expressed concerns related to how their substance use was influenced by their peers (66%, n = 33), the environment they were living in (60%, n = 30), and their family (50%, n = 25). Sixteen participants provided detailed narratives of their lived experiences that permitted further in-depth analysis. Thematic analysis of these narratives revealed five interrelated themes; introduction to drugs and alcohol, family dynamics access to drugs, attempts at giving up, and motivation to stop. The use of a Talanoa approach, whilst administering a screening tool, such as the ASSIST, allows for a more in-depth exploration of an individual's substance use. The information gathered would allow those working with Pacific people who misuse alcohol and/or drugs to develop culturally appropriate interventions.


The tropospheric oxidation cycle of the hydroxyl radicals HOx, HO, HO2 contributing to the chemical activity of the troposphere is studied. Of special importance are the variations of CH4-concentrations and its oxidation products. Runge-Kutta algorithms are used to study 25 carbohydrates reacting in 60 chemical reactions. Results in the absense and the presence of CH4 are given.


When college kids make mashups of Hollywood movies, are they violating the law? Not necessarily, according to this study on copyright and creativity. The study shows that many uses of copyrighted material in today?s online videos are eligible for fair use consideration. The study points to a wide variety of practices ? satire, parody, negative and positive commentary, discussion-triggers, illustration, diaries, archiving and of course, pastiche or collage (remixes and mashups) ? all of which could be legal in some circumstances.


Based on the zero-sequence component of the reference voltages, this paper comprehensively analyzes the neutral-point variation and balancing control for three-level neutral-point-clamped inverter. An analytical method is proposed to accurately calculate the injected zero-sequence voltage for NP balancing. Based on the analytical analysis, the limitation of NP balancing control is revealed and the NP-fully-controllable region is presented. A real-time NP balancing algorithm is proposed as well. The feasibility of the proposed method is verified using simulation results for a 6 kV/1800 kVA medium voltage drive.


To study the new bone formation in the bone defect area after implantation, the tetracycline tracing method was used. The results show that new bone formed in 1 month, and the formation rate of new bone was very high (8.164μm/day),considerably faster than that of control groups (3.219μm/day).The new bone grew up quickly and βTCP particles were surrounded by double fluorescence bands which became more obvious. The new bone formation rate was maximal at 2 months, and then gradually reduced. The rate was steady at 4 months, and then reduced to resembling as the normal physiologic metabolism of bone, which indicated the implanted materials were completely replaced by bone. Calcium phosphatematerials had the ability of osteoconduction.


Abstract Fast dynamic response and high-frequency switching make the active power filter an appropriate converter to implement the correction of low-power quality events and impose a sinusoidal current in the grid at the point of common connection. In this article, a new simple and robust control structure for an active power filter is designed, simulated, and tested. The current loop, based on the DC bus energy balance, is intuitive, robust, simple to implement, and allows a fast dynamic response. The implementation is validated with simulated and experimental results obtained in a three-phase 5-kVA prototype.


As in many other countries, the Canadian labor market has experienced a very important change during the past 15 years: organizations are increasingly consti tuted of a core of permanent employees with core competencies responsible for essential tasks and a group of temporary workers in charge of work considered peripheral to the success of their business (Booth, 1997: 1; Grenon and Chun, 1997). In both the cases of the private sector and the public sector, this phenome non worries many observers. Non-permanent employees are generally paid less than their permanent co-workers, the fringe benefits they receive are less important, and women and the young are over-represented among them (Grenon and Chun, 1997: 25). Within the organization they are considered as second-class citizens. Some problems may concern more specifically the public sector. According to many civil servants, the increasing use of a temporary workforce within the Canadian public administration (federal government) could undermine some of its core values or simply constitute an inappropriate application of a private sector recipe to a system too complex and too different to assimilate it without negative side-effects. The values of merit, loyalty, neutrality, secrecy are those that are the most often described as endangered. In this article, we will try to answer two main questions: are we witnessing the advent of a more precarious public employment in Canadian public administra tion? and what effect does temporary employment have on traditional core values of the civil service? We will define a non-career civil servant as a government employee who is hired for a specified period of time and whose contract establishes an employer–employee relationship. Therefore many types of workers, who all are employed by the Canadian government, are excluded from this definition: parttime permanent employees, seasonal permanent employees, employees hired through a contract for service 1 (such as consultants) and temporary help agencies' staff (because they are not under a direct contract with the government).


Objective: Through the analysis of economic running situation of 15 county level hospitals from 2007 to 2011 in Zunyi,clarify the existed problems and propose the policy suggestions.Methods: Collect related data of these hospitals from 2007 to 2011,and dissect the current situation by using the statistical descriptive method.Results: The general economic running of county level hospitals in Zunyi is stable,while the ability of gaining profits and the debt paying is low.Thus the development potential is huge.Conclusion: To solve the problem of heavy debt burden,low efficiency of fund utilizing,and in-depth of cost accounting of Zunyi county-level hospitals;it was proposed that the debt's scale of the hospitals should be controlled,internal management should be strengthened,and full cost accounting should be implemented.


In this paper, I intend to make the point that there is nothing as good as confronting a museum artefact in person. There is nothing as good as seeing a performance in real life. But given the possibility of now being able to broadcast or archive a digital version of an object or performance over the web, what might be the best way of doing that? I will not really provide a conclusive answer to that question. I, perhaps, have quite an unusual perspective on this issue; firstly because I am an artist, and secondly because the work I have done in museums is not 'normal' in terms of museum work. That work is exemplified by the two projects 'Is someone coming to get me?' and 'Towards a museum of zeroes and ones', both undertaken with Kris Cohen, at the time a fellow in the Sociology Department at the University of Surrey.


1 College of Marine Science, University of South Florida, St Petersburg, FL, USA. 2 Dept, of Oceanography, Texas A & M University, College Station, TX, USA. 3 Dept of Oceanography,University of Hawaii at Manoa, Honolulu, HI, USA. 4 Department of Earth Sciences, University of Southern California, Los Angeles, CA. USA. 5 School of Geoscience, Univerity of South Florida, St Petersburg, FL, USA. *correspondence: firstname.lastname@example.com


A comparative analysis for tribological behaviour of PTFE (Polytetrafluoroethylene) composites with different filler material are investigated showing wear rate and coefficient of friction are compared with PTFE composite with different filler material on the effect of load and sliding velocity. It is used to investigated, coefficient of friction decreases with increases in load. In these investigation a comparative analysis of three different combination material investigated are  PTFE+25%glass filled, PTFE+25% glass filled +5% graphite , PTFE+25%glass filled+5%  molybdenum disulphide is presented. Wear and coefficient of friction comparatively evaluated on a pin-on-disc configuration and using Taguchi's technique. The result of experiments proves that wear is strongly affected by the composition of filler content in PTFE


The purpose of this study is to substantiate and test in the context of the specialization of agricultural enterprises of the Kirov region a risk-oriented approach to assessing the impact of a number of factors that allow identifying promising directions for the development of agricultural production at the planning stage.The objectives of the study are to apply a risk-oriented approach to assessing the impact of economic, natural-climatic and technical factors on the strategic development of agricultural production in the region (municipality). Methodology. This article uses the factor and variance analysis method.


(57) Abstract: general formula (I) S- substituted 11β- benzaldoxime - estra-4,9-dien - carbonic thiol ester and pharmaceutically acceptable salts, the preparation and the of the compound pharmaceutical formulations containing the compounds are described. This compound is coupled to the progesterone receptor, and apparently have a reduced antiglucocorticoid effect.


Large scale, organization-wide groupware systems are high risk development efforts. Requirements gathering and early evaluation are constrained by the need for the system to attain a critical mass of users and content. One approach to mitigate this risk is to employ Wizard of Oz style system simulations during the requirements gathering phase. While this method has historically been used to test quasi-functional system prototypes, we have found it to be a useful method for assessing organizational feasibility. After introducing this adaptation of the Wizard of Oz method, our approach is grounded with a case study in which it is was successfully used as a proof-of-concept requirements gathering exercise for an expertise recommender and organizational memory system project. Transferable lessons learned are distilled and discussed.


In our previous study [Hong Y, Brown DG (2009) Appl Environ Microbiol 75(8):2346–2353], the adenosine triphosphate (ATP) level of adhered bacteria was observed to be 2–5 times higher than that of planktonic bacteria. Consequently, the proton motive force (Δp) of adhered bacteria was approximately 15% greater than that of planktonic bacteria. It was hypothesized that the cell surface pH changes upon adhesion due to the charge‐regulated nature of the bacterial cell surface and that this change in surface pH can propagate to the cytoplasmic membrane and alter Δp. In the current study, we developed and applied a charge regulation model to bacterial adhesion and demonstrated that the charge nature of the adhering surface can have a significant effect on the cell surface pH and ultimately the affect the ATP levels of adhered bacteria. The results indicated that the negatively charged glass surface can result in a two‐unit drop in cell surface pH, whereas adhesion to a positively charged amine surface can result in a two‐unit rise in pH. The working hypothesis indicates that the negatively charged surface should enhance Δp and increase cellular ATP, while the positively charged surface should decrease Δp and decrease ATP, and these results of the hypothesis are directly supported by prior experimental results with both negatively and positively charged surfaces. Overall, these results suggest that the nature of charge on the solid surface can have an impact on the proton motive force and cellular ATP levels. Biotechnol. Bioeng. 2010;105: 965–972. © 2009 Wiley Periodicals, Inc.


During the Pleistocene (approximately 2.6 Ma to present) glacial to interglacial climate variability evolved from dominantly 40 kyr cyclicity (Early Pleistocene) to 100 kyr cyclicity (Late Pleistocene to present). Three aspects of this period remain poorly understood: Why did the dominant frequency of climate oscillation change, given that no major changes in orbital forcing occurred? Why are the longer glacial cycles of the Late Pleistocene characterised by a more asymmetric form with abrupt terminations? And how can the Late Pleistocene climate be controlled by 100 kyr cyclicity when astronomical forcings of this frequency are so much weaker than those operating on shorter periods? Here we show that the decreasing frequency and increasing asymmetry that characterise Late Pleistocene ice age cycles both emerge naturally in dynamical systems in response to increasing system complexity, with collapse events (terminations) occuring only once a critical state has been reached. Using insights from network theory we propose that evolution to a state of criticality involves progressive coupling between climate system 'nodes', which ultimately allows any component of the climate system to trigger a globally synchronous termination. We propose that the climate state is synchronised at the 100 kyr frequency, rather than at shorter periods, because eccentricity-driven insolation variability controls mean temperature change globally, whereas shorter-period astronomical forcings only affect the spatial pattern of thermal forcing and thus do not favour global synchronisation. This dynamical systems framework extends and complements existing theories by accomodating the differing mechanistic interpretations of previous studies without conflict.


The availability of various methods of arc flash such as IEEE 1584–2018 and Ralph Lee methods have voltage, current and configuration limitations and hence do not provide a good estimate of incident energy under some conditions such as systems above 15kV. This was confirmed for higher voltages from tests conducted by the Electric Power Research Institute [1]. With the experimental data available from these tests, empirical equations were derived in simplified forms by using the average values of voltage gradient and incident thermal energy flux. These equations provide a suitable tool in estimating incident energy in high voltage systems. This paper describes those equations, analyzes the results produced with different input parameters and identifies resultant patterns to help engineers minimize incident energy and improve safety of the personnel.


The thermal conductivity and the pressure under working conditions of PTFE composite materials was numerical simulation by numerical simulation method with finite element analyze software ANSYS,and the thermal conductivity of PTFE and the pressure in different temperature and temperature tables were obtained.The analysis results of PTFE composites could provide reference basis for optimum design.


In industries, three-phase inductive loads such as induction motors are widely used due to their low cost, easy maintenance, reliability, and robustness. Due to inductive loads, the power factor is reduced which results in the wastage of power, high billing costs, and penalties from electric power supply companies. In order to resolve this issue, a system has been designed for the power factor improvement of three-phase loads using the programmable logic controller (PLC) which will definitely minimize the operation cost of the plant, and also the demand for electricity supply on utility side will be reduced. The system is implemented by a combination of Hardware and software. The software consists of PLC programming whereas hardware consists of power and control circuits along with the protective devices. The programming of PLC is logic based which controls step by step sequence of operations. When the inductive load adds to the system, PLC will read the signal as an input from the contactor coil of the magnetic contactor connected with the motor and will send the signal as an output to the corresponding contactor coil of the magnetic contactor to switch the appropriate capacitor bank in order to improve the power factor. The experimental results for seven different cases utilized by different combinations of loads, without and with the use of the developed system have been discussed in this paper. So, from the perspective of energy management, we have always a need to improve the power factor of the Load. Due to many industrial control applications, the PLC is used as a power factor controller (PFC).


To develop a duplex fluorescence quantitative PCR for detecting Legionella,based on TaqMan hybridization probes technology,two pairs of primers and two MGB probes were designed to identify the 16S rDNA and mip gene respectively.The 16S rDNA probe was 5'end labeled with FAM and 3'end labeled with TaqMan-MGB,and then mip probe was 5'end labeled with HEX and 3'end labeled with TaqMan-MGB.The PCR reaction conditions were optimized.By this method of detection Legionella,legionella pneumophila,non-legionella pneumophila and other bacteria were detected.The specificity,sensitivity and reproducibility of the assay were evaluated.All the Legionella tested were positive for 16S rDNA gene by using this assay except LP12,LP13,while all the Legionella pneumophila and L.micdadei were positive for mip gene.The sensitivity of this assay was 10 copies/μL.The coefficients of variation(CV)value were 0.2%-0.6%.and the whole process costs 2h.It is evident that Legionella can be detected by using duplex fluorescence quantitative PCR,which is specific,rapid and sensitive to detection L.pneumophila and other Legionella spp.


ABSTRACTThe spread of the Internet is leading to irreversible changes in the existing structures of the economy, management and society. The aim of this long term empirical study is to document and interpret structural changes resulting from the establishment of electronic market places. Hypotheses describing these changes form the starting point for this study, and their accuracy will be tested using regular, repeated opinion surveys. The basis of this study was laid with a first extensive survey, and at intervals of two years follow-up surveys will be made.


Mission-critical multimedia applications such as advanced command and control are dynamic and criticality-driven. Taking into consideration the application criticality as well as media quality-of-service (QoS) and timing requirements, we develop a multiresource management system that enables criticality-based resource preemption and QoS-based dynamic resource negotiation and adaptation. Our performance study indicates that our approximation solution is near optimal and that it outperforms a criticality-cognitive baseline algorithm. We also show that the dynamic QoS adjustment technique largely improves the quality of service for video streams. The criticality and QoS-based multiresource management system is part of the Presto multimedia system environment prototyped at Honeywell for mission-critical applications.


Using the ANSYS software based on the finite-element method,the heat distribution of the LED in three different package structures are simulated and compared,and the effect of the different package structure on the ability of high power LED cooling capacity is analyzed.The effect of the air convection on the cooling for the LED package is also presented.It shows that forced cooling is the key to solve the LED cooling problem.


(57) Abstract: The semiconductor integrated device such as a transistor, is formed with a film of semiconductor material formed on a substrate. To improve device characteristics, the semiconductor material has a regular, semi-regular single crystal structure. This structure, film locally exposed to by using one or several pulses of laser radiation beam, the film is produced by techniques which involves locally melting over the entire thickness. Thereafter, the molten material is locally solidified from the seed region of the membrane. The semiconductor device, the pixel controller and driver of the liquid crystal display device and an image sensor, a static random access memory (SRAM), included silicon on insulator (SOI), and three-dimensional integrated circuit device.


Part I. Introduction: 1. Nature, scope and methods of managerial economics 2. Theory of the firm Part II. Demand Analysis: 3. Demand theory 4. Demand estimation Part III. Production and Cost Analysis: 5. Production theory 6. Cost theory 7. Cost estimation Part IV. Strategy Analysis: 8. Market structure and pricing 9. Game theory 10. Pricing strategy 11. Investment analysis 12. Government and managerial policy.


prior to undergoing routine amniocentesis in the second trimester. Cytogenetic analyses were available for all pregnancies; 54 cases of Down syndrome were identified. Details of this study population are published elsewhere (Haddow et al., 1994). Table I compares the performance of the proposed cut-off strategy with the currently accepted cut-off strategy. The three maternal age intervals deiined in the table have been selected so that equal numbers of Down syndrome pregnancies are included in each interval. The proposed strategy identifies 69 per cent of the Down syndrome pregnancies at an overall false-positive rate of 17 per cent. The currently used fixed risk cut-off strategy identifies 81 per cent of the Down syndrome pregnancies at the same 17 per cent falsepositive rate. The increase in detection is statistically significant (McNemar test of symmetry, P<O-OOl). In order to justify adding complexity to the currently accepted strategy of using a single fixed risk cut-off for women of all ages, any proposed strategy must be shown to be superior. This analysis does not support a recommendation to abandon the currrently used fixed risk cut-off strategy. GLENN E. PALOMAKI AND JAMES E. HADDOW Foundation for Blood Research, PO Box 190, Scarborough, ME 04070-01 90, U. S. A.


Objective To investigate the effects of different concentrations of parecoxib on proliferation and apoptosis of colon cancer LoVo cells.Methods The colon cancer LoVo cells were inoculated in cuhure plate and cultured for 24 h.The cells were randomly divided into 4 groups (n =6 each):control group (C group) and different concentrations of parecoxib groups (P1-3 groups).The cells were incubated with parecoxib 10,40 and 160μmol/L for 24 h in P1-3 groups respectively.The rates of proliferation inhibition were measured by MTT assay.The colony formation rates were measured by colony formation assay.The apoptotic rate was determined by flow cytometry.The Survivin and caspase-3 mRNA expression in the cells was detected by RT-PCR.Results Compared with C group,the rates of proliferation inhibition and apoptotic rate were significantly increased,the colony formation rates were significantly decreased,the expression of Survivin mRNA was down-regulated,and the expression of caspase-3 mRNA was up-regulated in a concentration-dependent manner in P1-3 groups (P < 0.05).Conclusion Parecoxib can inhibit the proliferation of LoVo cells and induce the apoptosis in LoVo cells in a concentration-dependent manner through down-regulating the expression of Survivin mRNA and up-regulating the expression of caspase-3 mRNA.

Key words:
Cyclooxygenase inhibitors; Colonic neoplasms; Cell proliferation; Apoptosis


Purpose:  This article aims to clarify the main theoretical and practical aspects of Ukraine's integrated reporting development process from organizational and methodological perspectives.

Theoretical framework:  Understanding the specifics of the production factors consumed and created by the company - financial, productive, human, intellectual, natural, and social - is the fundamental purpose of the organization's integrated reporting as one of the critical elements of the firm's performance.

Design/methodology/approach: The research used the analytical and bibliographic methods to study the scientific literature on integrated reporting development, as well as induction, deduction, analysis, synthesis of information, systemic and structural, comparative, logical and linguistic methods, abstraction, idealization for studying and processing data, and a questionnaire survey conducted by the research authors online to practically clarify the most critical issues related to the organizational and methodological aspects of the integrated reporting problem.

Findings:  Various forms of integrated reporting were available in Ukraine during the research period. Therefore, the concept of integrated reporting is relevant today for Ukraine and the whole world. However, the problems of implementing integrated reporting currently need to be sufficiently disclosed in domestic scientific studies, mainly due to their novelty and require further research.

Research, Practical & Social implications: The study identified the leading, most important theoretical aspects of the integrated reporting development issue and studied the opinion of scientists and managers of enterprises that use integrated reporting in their work on the critical elements of this issue.

Originality/value:  The analysis of the scientific literature on the research topic and the questionnaire survey results showed that the integrated reporting concept should be understood as a new approach to the purpose of reporting documentation, which consists in combining financial and non-financial indicators of the company's activities as a tool for socially responsible management to disclose information about the company's impact on the social and economic sphere, as well as on the future business development strategy.


In this study, we explored whether the two dominant, morphologically divergent, omnivores, Astyanax bimaculatus (Characidae) and Pimelodus maculatus (Pimelodidae) in the high diversity (>100 species) fish assemblage of the Neotropical Rio Tibagi (southern Brazil) exhibited full overlap in the use of feeding resources similar to those reported for closely related species in Rio Amazonas. Monthly feeding patterns were assessed in two years of contrasting hydrological conditions and were compared with those reported for other, allopatric populations within their distributional range. Astyanax and Pimelodus fed at all trophic levels and exhibited an acute ability to shift prey as a response to environmental variations or food shortage. Although aquatic and terrestrial insects and seeds of native and introduced plants were the major food items, spatial separation across the water column and ecomorphological constrains seem to prevent a simultaneous use of the same food items by the two species. Except when cultivated seeds (i.e. maize) were most abundant after harvest, overlap in the use of feeding resources was negligible, if any. We suggest that the assessment of trophic relationships in Neotropical fish assemblages require more detailed studies than those actually available.


This study aims to identify and analyze the ways in which semiotic resources are orchestrated by teacher-trainees during videoconferenced French foreign language teaching. Our corpus is made up of six weeks of interaction between seven teacher trainees enrolled in a master's program at Universite Lumiere Lyon 2 in France and 12 undergraduate business students at Dublin City University in Ireland. 15.5 hours of video data were transcribed using ELAN, and 195 lexical explanation sequences were identified. These sequences were categorized according to whether the lexical problem came from an inability to understand or an inability to speak, and were then split into phases according to a three-step canonical model (Lauzon, 2008). During each phase we look at which semiotic resources were used, combined and co-contextualized by the teacher trainees. Our methodology, which will be used to complete our PhD project, is outlined here as well as preliminary results.


This paper endeavors to create a better understanding of the barriers to employment faced by disadvantaged urban women in the post-welfare reform era. Using data from the Project on Devolution and Urban Change, a unique geographically-linked, longitudinal, multi-city set of survey data, logistic regression models weigh the relative importance of individual barriers to employment (poor health, childcare and family responsibilities, etc.) and contextual or neighborhood barriers to employment (poverty rate, joblessness rate, etc.) on labor market outcomes. Results reveal that several neighborhood characteristics are predictive of employment, including automobile access, female-headedness, vacancy, and disorder. Results suggest a more complex, nuanced interplay between neighborhood-level variables and individually-measured variables in preventing some women from obtaining both modestly paying employment with few allocated hours of work per week, and also better-paying jobs with more hours of work per week.


In a previous study [J Cell Physiol 1963(Dec); 62(3): 327-336] it was found that most macroscopic colonies formed from transplanted mouse marrow cells in the spleens of irradiated mice contained new colony-forming units (CFU). However, the distribution of such CFU among colonies was very heterogeneous, with many colonies containing few colony-forming cells, and a few containing very many. This result suggests that control of the self-renewal of CFU is lax. In the present paper, an analysis of this variation is presented which indicates that it might be generated by a well-known probabilistic ("stochastic") process, the "birth-and-death" process. For permission to reprint this article for other than personal noncommercial use, the individual authors of articles should be contacted. See: http://www.pnas.org/misc/nlmterms.shtml (and also, http://www.pubmedcentral.gov/about/copyright.html).


A systematic study was undertaken to assess the influence of basalt fines and coarse aggregate on the durability of concrete. See also 21-914 for complete proceedings. -- AATA


The geological condition of 9# mine is complicated and common mining technioues are less helping.Automatic slicers are applied to increase output of 9# mine by Shanxi Jincheng anthracite coal mining group.This paper introduces the application of automatic slicer in 95313 working face in Fenghuangshan mine of Shanxi Jincheng anthracite coal mining group.


This article presents a rare case of combination of Ebstein's anomaly with critical aortic coarctation in a newborn baby, who was admitted to the neonatal intensive care unit of the Regional Children's Hospital needed urgent surgical correction. Purpose — to conduct a literature review of the clinical cases of association of Ebstein's abnormality with critical aortic coarctation in newborns and to present a clinical case of such a rare combination in a newborn boy. Clinical case. A newborn boy was admitted to the neonatal intensive care unit of the Lviv Regional Children's Hospital OHMATDYT, on the second day after his birth with an established diagnosis of Ebstein's anomaly. On admission, the child's general condition was moderate. On ausculation: rhythmic heart tones, tachycardia (heart rate 160 bpm), loud S2 above the pulmonary artery and loud 4/6 systolic murmur across the left sternal border and under the left scapula. The weakened pulsation of the femoral arteries was determined. On Echocardiographic examination: critical aortic coarctation and Ebstein's abnormality have been diagnosed, which is an extremely rare combination. Clinically on the 6th day of the child's life condition significantly worsened: respiratory and cardiovascular failure increased, diuresis decreased, urea and creatinine levels increased. The child was urgently transferred to the intensive care unit to the pediatric cardiac surgery center, where a surgical correction of aortic coarctation was successfully carried out. Surgical correction of Ebstein's anomaly was not performed. Conclusions. The presented clinical case is extremely rare, despite the combination of Ebstein's anomaly and aortic coartation in the neonatal period is not described in the literature, specialists of ultrasound diagnostics should closely monitor the protocol of echocardiographic examination and conduct it in full to diagnose the pathology and perform a timely surgical correction. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: Ebstein's anomaly, critical aortic coarcia, newborns.


A gap in living standards between one country and another i s the fundamental cause of international migration. But it takes more than this to make people actually move. They may, for example, be pushed by some sudden change in local circumstances, or they may be exposed to hitherto undreamed-of alternatives in other countries. Globalization contributes to both of these processes by shaking up settled communities and offering new horizons that stretch way beyond the borders of the village or the nation. The link between economic development and migration is well established. Mass emigration from Europe to North America and Australia from the mid-19th century onwards can be fairly closely correlated with social and economic transformations—changes in agricultural productivity, a growth in rural population, and the onset in each country of the Industrial Revolution. People unable to find work in the countryside were driven to the cities. Most of them succeeded and remained in their own countries. But the process was very uneven, and many who found themselves shaken loose from the countryside were unable to find work in the cities and had to try their luck overseas.


The majority of persons with upper limb amputation use body-powered prostheses due to simplicity, robustness, and low cost. However, little is known concerning the daily use, function, and average force exertion for these bodypowered devices. In addition, body-powered prosthesis users must choose between a voluntary-opening (VO) and voluntary-closing (VC) device. It is yet to be determined whether a device capable of both VO and VC would provide added benefit and function. The two main objectives for this study were to quantify the actuation frequency and force exertion for bodypowered prosthesis users, and to investigate the impact of a novel VO/VC terminal device capable of being used in both VO and VC modes [1]. Four subjects with a trans-radial amputation were recruited and were fit with an instrumented harness. This harness contained load cell electronics in-line with the Bowden cable and measured the force exerted by the user to actuate the device, as well as the frequency with which the device was used on a daily basis. We also sent the subjects home with the novel VO/VC device, using the same mechanism to track the number of times they used the device as well as how often they switched the device between VO and VC modes. Following the home trial portion, all subjects performed outcome measures of Box and Blocks, Jebsen-Taylor Hand Function Test, Southampton Hand Assessment Procedure (SHAP), and Assessment of Capacity for Myoelectric Control (ACMC) with both their conventional and VO/VC devices, in randomized order. Subjects were also asked to complete a qualitative survey concerning their experiences with the VO/VC device. All subjects chose to use both modes of the VO/VC device during home use and during the outcome measures. Two subjects performed better at both the Box and Blocks and Jebsen-Taylor using the VO/VC device over their home device. One subject performed better on the SHAP using the VO/VC over their home device. Although the VO/VC device used in this study was experimental all subjects chose to switch modes during both their outcomes and in daily use. This suggests that devices capable of switching modes are useful. The qualitative feedback questionnaires identified room for improvement in the mechanism which could lead to improved outcomes and performance. VO/VC devices in general appear to be useful in daily life and warrant further research attention.


Methods: A retrospective cohort study was performed using the 2000–2012 Kids' Inpatient Databases. Pediatric patients admitted with a facial fracture diagnosis were included. Clinical outcomes include mortality, reduction of fracture during hospital stay, and open fracture reduction. Healthcare utilization outcomes include length of stay (LOS) and hospital charge. The impact of the Affordable Care Act (ACA) on patient demographics was also assessed.


Tax entertainment in the city of Manado has an important role for Regional Original Revenues, including regional development, job creation, as well as exploring sources of regional income. Therefore, each region is required to raise awareness for entertainment taxpayers, for their responsibilities in regional development. The purpose of this study was to determine the contribution of entertainment tax to local taxes, and the contribution of entertainment tax to, and the impact of entertainment tax on the city of Manado. The research method used is a qualitative descriptive analysis of the condition of natural objects, namely the reception of Local Original Revenue. The data used are observation, interview, and documentation. Resource persons from this study are the State Civil Apparatus, Regional Revenue Agency. The results showed that the Manado City Entertainment Tax revenue for four years, namely 2014 2017 experienced a change from an increase to a decrease in each year. There is a government effort through monitoring to optimize entertainment tax revenue. Hopefully, the government should conduct an examination in each district that has potential as a source of local tax revenue.


This paper points out some shortages existing in the modernization of sci-tech archives work and the challenges faced by the modernization of sci-tech archives work, and advances some corresponding countermeasures for solving these problems.


The fifth International Conference on Data Mining, Communications and Information Technology (DMCIT 2021) was held in Hangzhou, China from April 16 to 18, 2021, which is organized by Asia Pacific Institute of Science and Engineering (APISE), and media supported by MDPI-Mathematics. The conference strives to offer plenty of networking opportunities to meet and interact with the world-leading scientists, engineers and researchers as well as industrial partners in Data Mining, Communication Engineering and Information Technology Applications. DMCIT has been held for four years since 2017 after four successful conferences in Phuket, Shanghai, Beijing, and Virtually (2020), attracting a large number of researchers, scholars and students from almost all over the world. DMCIT 2021 is the fifth event and we continue to provide a unique and excellent forum to exchange research methodologies, explore practical applications, and foster innovative ideas, in Data Mining, Communication Engineering and Information Technology Applications. The conference was originally scheduled in Hangzhou from April 16 to 18, 2021. Due to the outbreak of COVID-19, we follow most current conferences and organize it as a hybrid conference, participants who cannot attend offline can also join online. The proceedings of this year's edition consists of 5 main categories: 1, Intelligent Processing based on Reasoning and Models; 2, Machine Learning Research and Appllications; 3, Classification Methods and Applications; 4, Mathamatical Modeling and Optimization; 5, Simulation and Implementation of Data Centric Approaches. The research tracks attracted 105 submissions from about 11 countries, among which 46 were accepted. All the submissions were rigorously reviewed by the conference Program Committee (PC). We have also selected 2 best oral presenter award and 1 best poster award. Four keynote speakers were invited to share their latest and insightful research ideas in the conference. We would like to take this opportunity to thank all the authors for submitting their papers to our conference. We also extend our appreciation to the invited speakers, PC members, supporting staff, as well as all the Organizing Committee members for their hard work, which eventually makes DMCIT 2021 a successful and fruitful event! Yucong Duan, Hainan University, China Conference Committee Chair, DMCIT 2021


enthusiasts. The editors should be congratulated on imposing reasonably consistent style and, more difficult, nomenclature. The flavour of the original meeting is captured in the volume. Most significantly, a new IGCP project was conceived (277: Phanerozoic Oolitic Ironstones) and I suspect this collection of papers will serve as the base from which many new and exciting projects develop. In this sense, I suspect the volume will become 'required reading' for anyone interested in these fascinating rocks. C. CURTIS


This Guide has been prepared by the Task Force for Environmental Design for the AASHTO Highway Subcommittee on Design. The Task Force was assisted by members of the Transportation Research Board Committee on Landscape and Environmental Design who served as technical authors for the Guide. It supersedes the 1970 Guide for Highway Landscape and Environmental Design. The scope of the Guide has been expanded to include all modes of transportation and the interaction of landscape considerations with transportation improvements. Specific emphasis has been placed on supplying technical information that will assist the planner, designer, project engineer, landscape architect, supervisor, and transportation manager to provide landscape features and integrate them into the transportation system, producing an environmentally pleasing facility. The Guide should be used as a basic reference to improve landscape and environmental design with specific guidance for the accommodation of transportation features which require aesthetic consideration. Additionally, this publication is intended to provide guidance in the design of new and major reconstruction projects. Sufficient flexibility is provided to encourage independent designs tailored to specific situations. The Guide is organized as follows: Foreword; Introduction; Chapter I - Integration of Landscape and Environmental Design in Transportation; II - Landscape and Environmental Elements in Highway Design; III - Environmental Design; IV - Landscape and Geometric Design; V - Construction Consideration in Design; VI - Roadside Management; VII - Highway Related Areas; VIII - Landscape Considerations for Airports, Mass Transit Facilities, Ports, and Railroads; IX - Multiple-Use/Joint Development; Glossary of Terms; and Selected Bibliography.


A membrane protein interacts with PKG and regulates calcium signals at multiple lifecycle stages in malaria parasites. Calcium signaling regulated by the cGMP-dependent protein kinase (PKG) controls key life cycle transitions in the malaria parasite. However, how calcium is mobilized from intracellular stores in the absence of canonical calcium channels in Plasmodium is unknown. Here, we identify a multipass membrane protein, ICM1, with homology to transporters and calcium channels that is tightly associated with PKG in both asexual blood stages and transmission stages. Phosphoproteomic analyses reveal multiple ICM1 phosphorylation events dependent on PKG activity. Stage-specific depletion of Plasmodium berghei ICM1 prevents gametogenesis due to a block in intracellular calcium mobilization, while conditional loss of Plasmodium falciparum ICM1 is detrimental for the parasite resulting in severely reduced calcium mobilization, defective egress, and lack of invasion. Our findings suggest that ICM1 is a key missing link in transducing PKG-dependent signals and provide previously unknown insights into atypical calcium homeostasis in malaria parasites essential for pathology and disease transmission.


In order to design new search strategies for collaborating autonomous underwater vehicles, a novel simulator was developed to model the diffusion of groundwater discharge in shallow coastal waters. The simulation allows for the evaluation of new search strategies without running the risk of losing expensive hardware during the field testing. The developed simulation is based on cellular automata. In order to reduce computational complexity, a novel two-dimensional cellular automaton with additional depth-information for each cell is used to simulate a three-dimensional nearshore environment. The influence of different neighbourhoods and cell shapes on the behaviour of the cellular automaton is examined and discussed. Results show a faster rise of discharged fluorescent dissolved organic matter for hexagon cells. Also all examined neighbourhoods converge to a stable state after a finite number of iterations.


The complexity of landslides makes it difficult to predict the spatial distribution of landslide susceptibility and hazard. Although in most European countries the basic preconditions for the occurrence of mass movements (rocks and topography) have been mapped in detail, the triggering factors (e.g. precipitation or earthquakes) are much less predictable. A detailed nation-wide inventory for Hungary provides a unique base for landslide susceptibility mapping. As the methodology for the assessment the technique applied in the ELSUS 1000 project was selected. The micro-regions of Hungary were identified where mass movements contribute to land degradation. The paper provides a statistical evaluation of the distribution of landslides, depicts landslide susceptibility on maps and reveals the role of anthropogenic factors in the generation of mass movements. The mid-resolution elevation model (SRTM1), land cover data (CLC50) and surface geology database (Mining and Geological Survey of Hungary) allowed for the derivation of a landslide susceptibility map more detailed than before. Along with its background information the map reflects and explains the differences in landslide susceptibility among the individual hilly and mountainous regions.


Laser cooling in semiconductor structures due to anti-Stokes luminescence is reviewed. Theoretical background considering luminescence trapping and red-shifting, the effect of free carrier and back-ground absorption, Pauli band-blocking, and the temperature-dependence of various recombination mechanisms are discussed. Recent experimental results demonstrating record external quantum efficiencies (EQE) in GaAs/GaInP heterostructures are described, and conditions favorable for the first observation of laser cooling in semiconductors are discussed.


A novel concept for a transistor was invented, introducing an idea for protection against saturation. It involves the use of a static induction transistor (SIT). Simulation showed encouraging switching times when compared to similar gates without protection, while the charge storage was practically eliminated.


In the initial deploying stage of wireless sensor networks,because of not being detected or hard to break by attackers,every node has ability to resist being hijacked.Based on onetime pre-shared key,a security management scheme SMOPK,suitable for static network,was introduced.The scheme used onetime pre-shared key to perform consultation of secret key,and therefore realizing secured links between neighboring nodes and building up a secured topology which is consistent with the actual wireless topology.Analysis showed that the scheme had strong security features with low cost.


Modern ICT solutions are capable of assisting dependent people at home and therefore able to replace the physical presence of a caregiver. However, the success of such solutions depends on an intuitive access to services. By proposing a speech-operated system and devices that facilitate this voice-based interaction, vAssist aims at a solution that corresponds to a virtual butler. The goal is to build a system with whom elderly users can interact naturally and even build up a social connection. Integrating modern language technology with a human-operated call center should allow for coping with current imperfect solutions and consequently offer the necessary reliability and user experience. vAssist is planned to be launched for German, Italian and French.


Spontaneous coronary artery dissection (SCAD) is a rare but increasingly recognized cause of acute coronary syndrome. Here, we describe SCAD in a 25-year-old female on long-term cabergoline therapy with no other cardiac risk factors. Cabergoline-induced SCAD should be considered in patients presenting with an acute coronary syndrome who are treated with this medication.


69 The phytohormone ethylene plays crucial roles in the negative regulation of plant 70 etiolated hypocotyl elongation. The microtubule cytoskeleton also participates in 71 hypocotyl cell growth. However, it remains unclear if ethylene signaling-mediated 72 etiolated hypocotyl elongation involves the microtubule cytoskeleton. In the present 73 study, we functionally identified the previously uncharacterized 74 microtubule-associated protein WAVE-DAMPENED2-LIKE5 (WDL5) as a 75 microtubule stabilizing protein that plays a positive role in ethylene-regulated 76 etiolated hypocotyl cell elongation. ETHYLENE-INSENSITIVE 3 (EIN3), a key 77 transcription factor in the ethylene signaling pathway, directly targets and upregulates 78 WDL5 . Etiolated hypocotyls from a WDL5 loss-of-function mutant ( wdl5-1 ) were 79 more insensitive to ACC treatment than the wildtype. Decreasing WDL5 expression 80 partially rescued the shorter-etiolated-hypocotyl phenotype in the ethylene 81 overproduction mutant eto1-1 . Reorganization of cortical microtubules in etiolated 82 hypocotyl cells from the wdl5-1 mutant was less sensitive to ACC treatment. These 83 findings indicate that WDL5 is an important participant in ethylene signaling 84 inhibition of etiolated hypocotyl growth. This study reveals a mechanism involved in 85 ethylene regulation of microtubules through WDL5 to inhibit etiolated hypocotyl cell 86 elongation. 87


Accidents are the main cause of fatalities. These can occasionally lead to patients staying in the hospital for an extended period of time. Because of the witnesses` late arrival at the scene of the accident, the victim frequently dies. In this project, a real-time Police and ambulance drivers will be informed and given an alert system as a remedy to this issue. In order to detect falls, mobile phones are employed as readily available technical instruments. For fall detection, an Android smart phone with an embedded accelerometer is employed. The phone`s vibration frequency will be evaluated by the accelerometer in order to determine the frequency of the fall. Various factors, including vibration frequency and height, are taken into account while evaluating the threshold. A pop-up notice is displayed for the user`s input if it exceeds the predetermined threshold. The next step is decided upon by the user`s response. If users don`t answer within a given time frame, an alarm and notification will be promptly sent to the necessary pre-specified people, whose contacts the user gave while enrolling for the programme. Drivers of the police car and am balance are also provided an alert and notice, or SMS, with the location of the victim`s accident. The technology described in this research uses an intuitive, straightforward Android app to detect fall at a low cost.


Water management in river deltas is increasingly being challenged by pressures from population growth, sea level rise, increasing variability in river runoffs, and potential climate change. Adaptation to such changes is not only determined by what is known or anticipated at present, but also by what will be experienced and learned as the future unfolds, as well as by policy responses to social and water events. As a result, a pathway emerges. Instead of responding to surprises and making ad hoc decisions, exploring adaptation pathways into the future will provide indispensable support to water management decision-making. We have developed a structured approach for designing a dynamic adaptive policy based on the concepts of adaptive policy making and adaptation pathways. Such a policy can change over time in response to how the future unfolds, what is learned about the system, and changes in societal preferences. Ingredients of this approach are: (a) transient scenarios (time series of various uncertain developments such as climate change, economic developments, societal changes), (b) a methodology for exploring many options and sequences of these options across different futures, and (c) a stepwise policy analysis. We have applied the method to two cases, a hypothetical case based on a river branch in the lower Rhine Delta, and a real- world case for the Rhine Delta in the Netherlands. In this paper, we describe the approach and lessons learned based on these two cases.


The proportion of Swiss households that own their home has always been in the vicinity of 30 percent, the lowest proportion in the OECD. Clearly the existing, essentially federal, policy for promoting home ownership has not been very aggressive. A survey allows us to understand what households wish and why they are so few to own a home. Those observations, in particular the fact that households wish to buy a single family home rather than an apartment, have consequences for the optimal allocation of the responsibility for promoting home ownership. I conclude that the responsibility should be passed down to the cantons.