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Plazomicin is an FDA-approved aminoglycoside for the treatment of complicated urinary tract infections. In this open-label study, 24 adults with normal renal function or mild, moderate, or severe renal impairment (n = 6 per group) received a single 7.5-mg/kg of body weight dose of plazomicin as a 30-min intravenous infusion. Total clearance declined with renal impairment, resulting in 1.98-fold and 4.42-fold higher plazomicin exposures, as measured by the area under the concentration-time curve from 0 h to infinity, in subjects with moderate and severe impairment, respectively, than in subjects with normal renal function. (This study has been registered at ClinicalTrials.gov under identifier NCT01462136.)
Gram-negative bacteria have become increasingly resistant to multiple antibiotics (1–3), and treatment options for infections due to multidrug-resistant Enterobacteriaceae are limited (4, 5). Plazomicin is an aminoglycoside that was engineered to overcome aminoglycoside-modifying enzymes, the most common mechanism of aminoglycoside resistance in Enterobacteriaceae. In vitro, plazomicin has bactericidal activity against multidrug-resistant Enterobacteriaceae, including strains that produce extended-spectrum β-lactamases (6), carbapenemases (7, 8), and most aminoglycoside-modifying enzymes (9, 10). Plazomicin is approved by the U.S. Food and Drug Administration for the treatment of complicated urinary tract infections, including pyelonephritis (11).
Similar to other aminoglycosides, plazomicin displays linear dose-proportional pharmacokinetics (PK) (12, 13), has low plasma protein binding (∼20%), and does not undergo metabolism. As plazomicin is eliminated primarily via urinary excretion of the parent drug (14), we evaluated the impact of renal function on the PK of plazomicin.
This open-label phase 1 study (ClinicalTrials registration no. NCT01462136) was conducted at three U.S. centers from 2011 to 2012. The protocol was approved by the institutional review board at each site. All subjects provided written informed consent. The study included a screening period of ≤21 days, treatment on day 1, collection of PK samples on days 1 to 5, and follow-up evaluation on day 14. Adults with normal renal function or preexisting renal impairment age 18 to 75 years with a body mass index (BMI) of 19 to 32 kg/m2 and body weight of ≥40 kg were eligible for enrollment. Subjects requiring hemodialysis or peritoneal dialysis were excluded. Eligible subjects were stratified based on the mean of two predose creatinine clearance (CLCR) values, as estimated by the Cockcroft and Gault equation (15), and were enrolled concurrently into the mild (CLCR, 60 to 89 ml/min), moderate (CLCR, 30 to 59 ml/min), or severe (CLCR, 15 to 29 ml/min) renal impairment group (n = 6 per group). Subjects in the normal renal function group (CLCR, ≥90 ml/min) were enrolled and treated only after dosing had been completed in the renal impairment groups. Staggered enrollment was employed to approximately match the demographic characteristics of subjects in the normal renal function group with those of subjects in the renal impairment groups.
A single 7.5-mg/kg of body weight dose of plazomicin was administered via a 30-min intravenous infusion. The single 7.5-mg/kg dose was selected to avoid high plazomicin exposures in subjects with severe renal impairment. Blood samples were collected before dosing and at 36 and 45 min and 1, 1.5, 3, 6, 10, 16, 24, 36, 48, 72, and 96 h after the start of infusion. Noncompartmental PK analysis was conducted using Phoenix WinNonlin v.6.1 (Pharsight Corp., Mountain View, CA, USA) (details are described in the supplemental material).
Twenty-four subjects were enrolled and completed the study. The mean age was 63.9 years (range, 50 to 75 years). While the renal function groups were well matched for age and sex, values for mean body weight and BMI were slightly higher in the normal renal function group than in the impaired renal function groups (Table 1).
Plazomicin plasma drug concentrations declined in a multiphasic manner over time in each renal function group (Fig. 1). Subjects with mild renal impairment had plazomicin plasma concentration-time profiles that were comparable to those in subjects with normal renal function. Mean plazomicin plasma concentrations were higher in subjects with moderate and severe renal impairment than in subjects with normal renal function.
Following a single dose of plazomicin, maximum concentration of drug in plasma (Cmax) values did not appear to be impacted by renal impairment (P > 0.05; Table 2). Plasma exposures based on the area under the plasma concentration-time curve from time zero to infinity (AUC0–∞) were similar in subjects with mild renal impairment and normal renal function, but they were 1.98-fold and 4.42-fold higher in subjects with moderate and severe impairment, respectively, than in subjects with normal renal function (Table 3). The volume of distribution at steady state (Vss) was approximately 20% to 30% lower in subjects with renal impairment than in subjects with normal renal function. Total clearance (CLT) values were not notably different in subjects with mild renal impairment versus those with normal function but were substantially lower with moderate and severe impairment than with normal renal function (Table 2).
A single 7.5-mg/kg dose of plazomicin was well tolerated across renal function groups. Three adverse events were reported, none of which was considered by the investigator to be related to plazomicin. The results of the safety analyses are provided in the supplemental material.
Our results show that similar to other aminoglycosides (16, 17), the PK of plazomicin is impacted by renal function. Total clearance declined with renal impairment, resulting in significantly increased plazomicin exposures with moderate and severe impairment. Given the magnitude of increases in AUC0–∞, adjustments to plazomicin dosing are indicated for patients with moderate or severe renal impairment to attain a range of exposures similar to those of patients with normal renal function (11).
Similar to other plazomicin PK studies and to other aminoglycosides, the Vss for plazomicin approximated the extracellular fluid volume of 15 to 25 liters (12, 13, 18–20). Lower mean Vss values observed with renal impairment than with normal function may in part be related to the slightly higher body weights in subjects with normal renal function than in those with renal impairment.
A strength of this study is that PK was evaluated in subjects with a broad range of baseline CLCR, including three subjects with CLCR of <20 ml/min. An important limitation is the exclusion of subjects with end-stage renal disease requiring dialysis, precluding evaluation of the impact of renal replacement therapy on plazomicin PK. In conclusion, while dosage regimen adjustments of plazomicin do not appear to be warranted for patients with mild renal impairment, dosage adjustments are recommended in patients with moderate or severe renal impairment.
Data availability.Individual participant data that underlie the results reported in this article, after deidentification, will be made available (unless prohibited by applicable law) to researchers for noncommercial purposes beginning 6 months following article publication; proposals should be directed to datarequests{at}achaogen.com.
We thank INC Research (Raleigh, NC, USA), Almac Group (Souderton, PA, USA), ACM Global Laboratory (Rochester, NY, USA), Alturas Analytics, Inc. (Moscow, ID, USA), the Institute for Clinical Pharmacodynamics (ICPD, Schenectady, NY, USA), Jamie P. Dwyer (Vanderbilt University Medical Center, Nashville, TN, USA), Lynn E. Connolly, Tony Baca, Robert Cass, Todd Clobes, and Jen Yang.
Editorial support was provided by Jean Turner and Kate Bradford of PAREXEL and funded by Achaogen, Inc.
This project was funded in whole or in part with federal funds from the Biomedical Advanced Research and Development Authority (BARDA), Office of the Assistant Secretary for Preparedness and Response, Office of the Secretary, Department of Health and Human Services, under contract no. HHSO100201000046C.
A.S.K., J.A.G., and J.D.S. are employees or former employees of and stockholders in Achaogen, Inc. S.V.W. is a former employee of the Institute for Clinical Pharmacodynamics and received research funding from Achaogen, Inc. V.R. is a paid contractor with Achaogen, Inc.
- Received 29 May 2018.
- Returned for modification 16 June 2018.
- Accepted 29 August 2018.
- Accepted manuscript posted online 1 October 2018.
Supplemental material for this article may be found at https://doi.org/10.1128/AAC.01128-18.
- Copyright © 2018 Komirenko et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.


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The Came-Single 3-Axis handheld gimbal is a perfect lightweight solution for a number of smaller, high-performance cameras, such as the Panasonic GH4, Sony a7S, and Blackmagic Pocket Cinema Camera. A fascinating and easy to use device, we spoke with Camera Motion Research's Richard Greb for more on this upcoming product.Read More 0
One of the joys of today's age is seeing entire product lines birthed from Kickstarter. One such product line was on display from BeeWorks, the BeeWorks5, is a handheld camera stabilizer and remote that makes it a dream to get stable and cinematic handheld shots with a number of small form cameras.Read More 0

subset: commoncrawl


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Call of atlantis Call of Atlantis on PC / Windows 7.8.10 & MAC
Call Of Atlantis – once there was an ancient state of Atlantis, but its inhabitants angered the god Poseidon, and as a punishment he hid it forever under water. Poseidon. Embark on an exciting adventure, visiting various ancient cities of Greece, Egypt and others, collecting


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You Gotta Know These Rocket Scientists
- Robert Goddard was an early explorer of the theory and practice of launching rockets. His work provided the foundation for modern rocketry: in particular, gimballed engines (engines where the exhaust nozzles can change direction allowing the rocket to be steered), fuel pumps, steering with vanes, and gyroscopic stabilization. His seminal monograph on the subject was 1919's A Method of Reaching Extreme Altitudes. The next year, he put forward a concept for a rocket launch to the moon that was widely ridiculed in the press as being unrealistic. Goddard is the namesake of the NASA Goddard Spaceflight Center in Maryland.
- Konstantin Tsiolkovsky's interest in science manifested first through his science fiction writings, but he gained more notoriety for his eponymous rocket equation. The Tsiolkovsky equation, as published in 1903's Exploration of Outer Space by Means of Rocket Device, relates a rocket's speed with its mass, the speed of its exhaust, and the exhaust's mass (an application of Newton's laws of motion.) The equation is also connected with the idea of specific impulse, a measure of a rocket's efficiency. Tsiolkovsky also published theoretical studies on the capabilities of multi-stage, liquid-fueled engines, gyroscopes, and escape velocities.
- Hermann Oberth imagined at the age of 14 a recoil rocket, which could propel itself by exhausting gas from its base. He also lends his name to the Oberth effect, a phenomenon by which rockets operate more efficiently when moving at higher speeds, and formulated the idea behind multiple-stage rocketry. Oberth also mentored many German rocket engineers through the Verein für Raumschiffahrt (Spaceflight Society), whose formation was inspired partially by Oberth's writing.
- Wernher von Braun was at one time a student of Oberth in the Spaceflight Society. Von Braun is best-known for leading Nazi Germany's development and construction of the V-2 rocket (literally, "vengeance weapon"), which wreaked destruction on southern England during World War II. After World War II, he was recruited to the US as part of Operation Paperclip, and proposed to launch a space station carrying a nuclear arsenal (though he hedged the concept as "particularly dreadful"). He presided over Mercury-Redstone development as Director of NASA's newly-opened Marshall Spaceflight Center, which produced the rockets used in the Mercury spaceflights, and the Saturn V rocket used to launch the Apollo spacecraft.
- Hellmuth Walter designed the Starthilfe (takeoff assist) rocket propulsion units for the Messerschmidt Me 163 and the vertical-takeoff Bachem Ba 349 aircrafts, used by the German Luftwaffe in World War II. He also was awarded a patent in 1925 for suggesting that a catalyzed decomposition of hydrogen peroxide could provide oxygen for combustion.
- Sergei Korolev, known until his death by the pseudonym "Chief Designer", headed design and construction for the Soviet long-range ballistic missile program, as well as the R-7 ICBM program. This work urged similar innovations in the U.S. Earlier in his career, Korolev designed a rocket-powered glider, though he was imprisoned and forced into slave labor during the Great Purge. In the 1950s, he personally oversaw Sputnik and Sputnik 2, and he returned to the R-7, modifying it for lunar insertion of robotic probes. His final years were spent devising soft-landing methods for manned lunar missions.
- Theodore von Kármán was a fluid dynamicist by training. As a graduate student at Göttingen, he described the so-called Kármán vortex street (a form of turbulence in flow going past a cylinder, which is responsible for driving the vibration or "singing" of power lines) and went on to provide the theoretical basis for the idea of turbulent flows. He contributed to the construction of the wind tunnel at the Guggenheim Aeronautical Laboratory, which eventually became the Jet Propulsion Laboratory. He also formed the company Aerojet to develop short-takeoff aircraft technologies. The Kármán line is the accepted boundary between the Earth's atmosphere and outer space, and the Kármán ogive is the shape of the cone of rockets curving into the main body, which minimizes drag during rocket burn.
- Gene Kranz was a trained aeronautical engineer and pilot, he is best known for his Flight Directorship during the Mercury and Apollo projects. He presided over a departure from NASA's traditional incremental testing structure, in favor of a more aggressive, manned campaign ("all-up testing"). As part of the Apollo 13 "white team," Kranz and his associates engineered the free-return trajectory and human-factors management that brought the Apollo 13 crew back safely after a near-fatal spacecraft anomaly.
- Homer Hickam was inspired by seeing Sputnik fly overhead to study rocketry in his early teens. From his coal-company town in West Virginia, he and his rocket club, The Big Creek Missile Agency, designed modest-sized rockets and won the propulsion category of the 1960 National Science Fair. After serving in Vietnam, Hickam worked at the US Army Missile Command in Germany and Huntsville. Later, he moved to NASA, where he specialized in astronaut training. He trained crews for the Hubble Space Telescope's deployment extra-vehicular activity (EVA) and the first two servicing missions.
This article was contributed by former NAQT writer Zachary Pace.


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Listen now
to our podcast: Ethical & Sustainable Investing News to Profit By!
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DIY Ethical-Sustainable Investing Pays Tutorial
Coverage of
Investing for the Soul
The Web
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"Forty-five percent of U.S. households prefer an
environmental, social and governance (ESG) approach to
investing… Among those between the ages of 30 and 39,
this increases to 64%, and for those younger than 30, it
is 67%."
-- Cerulli Associates (USA)
October 2018
"The vast majority of Canadian investors are
interested in responsible investments (RI) that
incorporate environmental, social and governance (ESG)
issues, and they would be more likely to choose
responsible investments if their financial advisor
suggested suitable RI options for them." --
Responsible Investment
Association (RIA) (Canada)
"70% of people [in UK] want to invest
ethically but the financial services industry is failing
to respond." Referencing research by Abundance.
-- Acquisition
(UK) June 2015
Ethical Investing News/Commentaries
January 2018
Commentaries by Ron
If a link does
not work, please
e-mail us. Link may
only be valid a limited time.
Utilities may suffer 'significant losses'
from carbon taxes. "A new paper from
Trucost, part of S&P Dow Jones Indices, suggests
major companies across the electric utility,
chemicals and automaker industries could suffer
'significant losses' from new carbon pricing
policies or carbon taxes introduced as part of
nations' climate efforts."
It seems that some defensive stock plays might not
be so reliably defensive after all. Many investors
and fund managers might want to re-evaluate their
premises and holdings after reading Trucost's
Utilities may suffer 'significant losses' from
carbon taxes, by Madeleine Cuff, January 26,
2018, BusinessGreen, USA.
Just out, Corporate Knight's 2018 Global
100. "Companies from 22 different
countries made the 2018 list, with the U.S., France
and U.K. leading the pack. European companies
dominated the rankings, accounting for 69 per cent
of listed companies, while North America and Asia
accounted for 22 and 12 per cent respectively."
This is a ranking I always look forward to. And
European companies continue to lead in a
considerable fashion. Register to download the full
Corporate Knight's 2018 Global 100, January
2018, Corporate Knights, Canada.
Sustainable Fund Assets Under Management
Achieved Limited Gains in 2017 But Poised to
Increase Traction. "During a year when
a number of high profile environmental, social and
governance (ESG) related events unfolded,
sustainable fund assets under management in the US,
including mutual funds, exchange-traded funds (ETFs)
and exchange-traded notes (ETNs) achieved limited
gains. Estimated net inflows, including new 2017
fund launches, were $2.9 billion or 1.5%."
It's an old story. Despite retail investors saying
they're making ESG investments, the numbers continue
to show only modest growth in these assets.
According to many surveys, there seems to be much
better ESG take-up in pension, endowment, and other
institutional funds.
Sustainable Fund Assets Under Management Achieved
Limited Gains in 2017 But Poised to Increase
Traction, press release, January 22, 2018,
Sustainable Research and Analysis, USA.
Chinese index ranking companies by social
value commitment aims to help ethical investors.
"China Alliance of Social Value Investment says
its Social Value 99 index outperformed traditional
benchmark stock indices in a simulation."
demonstrates that ESG investing is gaining ground
in China.
Actual index information can be found
Hopefully, an English version of the page will be up
at some point.
Chinese index ranking companies by social value
commitment aims to help ethical investors, by
Karen Yeung, January 19, 2018, South China Morning
Post, China.
Millennial Investors Want Perks and ESG
Investing. "The latest Spectrem Group
report, 'Millennial and Generation X Investors,'
suggests these two generations are significantly
more attuned to socially responsible investing than
their older counterparts.
In fact, survey results show more than half
of Millennial investors (52%) see the social
responsibility of their investments as an important
selection criteria, compared with less than 30% of
WWII-era investors and 42% of Gen X investors.
The study also reveals that almost a third of
Millennial investors (29%) expect their financial
adviser to reward them with gifts or other favors in
exchange for their recurring business."
It's fascinating the degree to which millennial
investors want perks from their advisors! The rest
of the survey's findings continue to reinforce the
fact that millennials are much more interested in
ESG investing than other generations.
Millennial Investors Want Perks and ESG Investing,
by John Manganaro, January 18, 2018, Plan Advisor,
Larger Plans Continue to Outpace Smaller
Plans in Incorporating ESG Factors.
"While the top-line percentage was unchanged, plans
with more than $20 billion in assets increased
incorporation of ESG factors by 136% from 2013 to
2017, according to the findings. The authors note
that these plans now have the highest rate of
incorporation at 78%, compared to only 30% for the
smallest funds. ESG adoption across all plan sizes
has increased 68% since the firm′s first such survey
in 2013."
I wonder if one reason larger plans outpace smaller
plans in utilizing ESG criteria has to do with
staffing and resources of the plan managers?
Larger Plans Continue to Outpace Smaller Plans in
Incorporating ESG Factors, by Ted Godbout, NAPA,
State of Green Business Report 2018, by
GreenBiz/Trucost. "The report looks at
10 key trends and dozens of metrics assessing how,
and how much, companies are moving the needle on the
world′s most pressing environmental challenges. The
report is produced in partnership with Trucost, part
of S&P Global, a world leader in helping companies,
investors, governments, academics and thought
leaders to understand the economic consequences of
natural capital dependency."
The report is well worth reading for any ethical
State of Green Business Report 2018, January
2018, GreenBiz/Trucost, USA.
Demystifying negative screens: the full
implications of ESG exclusions. "In
this paper we explore the role of screening, the
activities typically targeted, the different ways
that exclusions are defined, and their effects on
investment strategies. Our aim is to help both those
investors with exclusion policies already in place
and those considering them to understand the options
available and the full implications of their
Shroders quantifies the effects of various negative
investment screens in a variety of investment
strategies such as growth, value, and income. It's a
pioneering work in this area and something that
anyone interested in ESG screening might want to
Demystifying negative screens: the full implications
of ESG exclusions, January 10, 2018, Sustainable
Investment Team, Shroders, UK.
MSCI links ESG with stronger asset
growth. "For calendar 2016 the managers
that scored the highest under MSCI's responsible
investment assessment recorded an average compound
annual growth rate of 3.7% in institutional assets
under management, vs. a 1.8% decline for those with
the lowest scores. Over the two years, the CAGR is
2.6% for the leaders vs. 1.6% for the lowest
scorers; and for the three-year period, those with
higher responsible investment scores saw 3.6% growth
in AUM, vs. 0.3% growth."
This is the first study of its kind that I'm aware
of. The results could give an impetus to fund
managers presently minimally or unengaged with ESG
to take it more seriously.
MSCI links ESG with stronger asset growth, by
Sophie Baker, January 8, 2018, Pensions &
Investments, USA.
Sexual Harassment Screens Making It Into
ETF ESG World. "Impact Shares, is
launching the first ETF focused on women empowerment
that will screen for sexual harassment. The fund
will contain around 200 to 300 stocks and will track
the Equileap North American Women's Empowerment
Index. The index applies 19 screening criteria,
which cover gender balance in leadership and
workforce, equal pay, flexible work options, safety
at work and freedom from violence, abuse and sexual
I suspect this will not be the only fund to advance
the cause. We'll probably hear from many ESG
oriented funds and managers that they'll similarly
screen for sexual harassment issues in their stock
Sexual Harassment Screens Making It Into ETF ESG
World, by Marie Beerens, January 5, 2018,
Investor's Business Daily/Nasdaq, USA.
Why managers need to wake up to ESG
threat. "'It will get to a point where,
if a fund group doesn′t have fully-implemented ESG
integration, and had it in place for sometime, we
won′t be able to use them anymore,' she [Teresa
Platan, who specialises in selecting emerging
markets and Japan equity funds for Aktia, a Finnish
bank] says. 'The shift has been so fast in the past
year with the clients suddenly asking so much about
ESG. It′s difficult to say exactly how long before
we′re there. Maybe only in a year or two.'"
The article's headline seems to imply a backlash
against ESG integration. However, as the quote
implies, it's really cautioning those investment
industry players not already on the ESG train to get
on-board now or lose business!
Why managers need to wake up to ESG threat, by
Dylan Emery, January 5, 2018, Portfolio Advisor, UK.
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Pizza Kit Delivery
*Pizza Kits available for delivery on July 2nd in both Worksop and Mansfield areas*
Delivery route includes Welbeck Estate, Worksop, Gateford, Carlton-in-Lindrick, North and South Anston, Cuckney, Warsop, Edwinstowe, Clipstone, Forest Town, Mansfield, Mansfield Woodhouse, Sutton-in-Ashfield, Teversal, Pleasley, Shirebrook, Langwith delivering 1-7pm on Thursday 2nd July 2020. If you are not sure if this would include you, get in touch before ordering.
Order cut-off is midday on Wednesday 1st July.
All dough balls and toppings will be delivered chilled and should be kept refrigerated until use.
Instructions included.


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In a world where individualism is taking over, we as a community want to go towards collectivism. It is important to us to bond and be a community that can depend on each other. That is why we have a food & fun day at FQ House every 3 months. The whole FQ sisterhood and their families are invited to celebrate health, life and good company. We try to make it fun so we set a theme, we bring food and we have fun together. This time the theme was a tropical spring. Anything that reminded you of the tropics was welcome. From floral prints, bright colors to Hawaii costumes, we had it all
"Because FOOD IS NOT THE ENEMY"
It is important to understand that food is not the enemy and that it should be enjoyed and shared with your loved ones! Yes you can be healthy and yes you are allowed to enjoy food! There is nothing wrong with that. That is why the center of the party is bringing food, eating together, being thankful and enjoying.
Updates, Recipes, Events & More


text: Even if this post looks like an early Fandom Friday Post – it's not. It is inspired by this great post and we thought we'd steal the idea, cause we're sneaky little hobbitses. So here we go, our five favorite fictional worlds that we would love to live in (cause there's quite a few great fictional worlds out there that we would never ever even consider living in, cause we'd die. In, like, seconds):


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March Madness: Expert takes, odds, French connections and more
Sam Rosenstiel and Sierra Newton, Editor-in-Chief, Sports Editor
March 22, 2019
It might be a longshot, but that would make an upset that much sweeter. The 14-seeded NKU Norse are taking the fight to Tulsa against 3-seed Texas Tech Red Raiders today at 1:30 p.m. in the school's second March Madness appearance since entering Division I. But how likely are the Norse to win? We ...
Men's basketball Horizon League schedule finalized
Matt Sexton, Sports Editor
September 9, 2015
HIGHLAND HEIGHTS, Ky. -- The men's basketball team announced its first-ever Horizon League schedule Monday morning, as well as game times for home contests. A Jan. 2 showdown at Green Bay will be the first Horizon League contest for the men's basketball team. The game will be carried on ESP...


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Visit the institution website for COVID‑19 updates
Entry requirements
You must have a primary dental qualification recognised by the General Dental Council (UK). You must have completed this at least two years before starting the course. You must be fully registered with the General Dental Council (UK) by the time the course starts. If your application is shortlisted you will be invited to attend an interview.
Months of entry
January, July
Course content
Our course will suit dentists with little or no implant dentistry experience. You will develop the skills to plan, treat and maintain implant cases. We provide the patients you treat on the course. The course satisfies the requirements of UK Training Standards in Implant Dentistry.
You will develop your intellectual skills through:
- case study analysis
- problem-based learning
- open discussion
- self-evaluation
You will develop your practical clinical skills through:
- one-to-one clinical coaching
- supervised clinical work carried out on patients
You will also gain experience in:
- minimal trauma extractions
- guided bone regeneration
- designing long-term maintenance plans
- how to establish implant dentistry into the practice setting
The course satisfies the requirements of the Training Standards in Implant Dentistry. This is endorsed by the General Dental Council (UK) at the level of 'straightforward placement of implants'. It also provides good preparation for dentists planning to sit the Diploma in Implant Dentistry. This is a recognised qualification, offered by the Royal College of Surgeons of Edinburgh.
Information for international students
To study this course you need to meet the following English Language requirements: Direct Entry: IELTS 7.0 overall (with a minimum of 7.0 in all sub-skills). Pre-sessional English Language courses are not accepted as an alternative entry to this course.
Fees and funding
See our course fees and funding web page in our online Prospectus.
Qualification, course duration and attendance options
- PGDip
- part time18 months
- Campus-based learningis available for this qualification
Course contact details
- Name
- Postgraduate Teaching and Learning Assistant, School of Dental Sciences
- email@example.com
- Phone
- +44 (0) 191 208 7631


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The Disney+ Star Wars Versions Appear to be the Current Blu-ray Cuts
With Disney+ just two months away, people are starting to wonder what versions of the Star Wars movies will stream on the service. While some are being realistic and realizing it'll be the same that we have on disc and digital right now, there are those holding out hope for non-Special Edition cuts.
Based on the test going on in the Netherlands, the versions being streamed are the current Blu-rays, and they even use the most-recent Blu-ray reissue art on the app:
The icons for the Star Wars movies on Disney+ from r/StarWars
Despite endless false rumors every time there's a new version of the Original Trilogy being released, there's never been any hard evidence that Lucasfilm wishes to go against George Lucas and reissue the original theatrical cuts.


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Henry's Fork 8-18-12
Keep watching the Henry's Fork Foundation web site for developments and discussions on coffer dam situation at the Ashton Dam. As Everet mention in his 8/16 "Today at Jimmy's" report, we have Mike Lawson's new book " Fly-Fishing Guide to the Henry's Fork" in stock. This book has all of Mike's angling knowledge on each part of this great river. No one knows the river in its entirety as well as Mike. This book proves it and sharing it demonstrates Mike's generosity. Mike offers that for several reasons August is his favorite month to fish the Harriman State Park reach of the Henry's Fork. That is right now, and the best source for strategy to do so is in his new book. Come in and pick up a copy now, or get in touch to have us put one aside for your next visit.


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When translation meets technologies: Language service providers (LSPs) in the digital age
Project: Research
- Dr Akiko Sakamoto (PI)
- Sarah Berthaud (PI)
- Jonathan Evans (PI)
- Dr Begona Rodriguez De Cespedes (PI)
With the emergence of new digital tools (e.g. computer aided translation tools, statistical machine translation, crowdsourcing, social media), translation has become an increasingly complicated process, materialised in a virtual network of stakeholders. This exploratory project solicits the views of one crucial set of stakeholders, Language Service Providers (LSPs), to gain a consolidated picture about how the industry is dealing with change. In collaboration with ITI (Institute of Translation and Interpreting), the largest professional body in the UK, we aim to propose strategies to deal with these new developments and disseminate examples of good practice within the profession.
|Effective start/end date
|1/09/15 → 31/08/16


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IPHCC – Interprofessional Teamwork Film Clips
From GITT (all 5 minutes): All film clips are of interprofessional teams, with negative and positive illustrations.
- Mrs. Cuervo (SW, NP, Pharmacist, Internist)
- Mr. Rosario (SW, NP, Pharmacist, Internist)
Multi-professional (silos) vs. Interprofessional Team
Interdisciplinary Thinking – its importance and value
Several Interprofessional Team examples in UK Communities
Interprofessional Team Education – from Western University, Pomona, California
- Western University was the first institution to develop a comprehensive program helping students from nine distinct health professions learn how to work as a cohesive health care team.
Last updated: 7/19/2018


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After successful Order of your Windows 8.1 Professional you will instantly receive:
• Access to your Windows 8.1 Professional License Key
• Official Full-Version Software
• Step-by-Step instructions to activate your Product
In order to install the software on your PC follow the instruction here.
In case of a problem with activating the product, contact us : email@example.com
This version of Windows works only on new installed Windows. If you purchase this version, you will need to re-install your Windows.
This product is valid for activating both 32 and 64 bit versions.
1. Please download and install correct edition of windows 8.1.
2. Go to 'Control Panel-All Control Panel Items-System ' and click 'Activate Windows' or 'Change Product Key'.
3. Click 'Activation' and enter the key you bought. Now your windows has been activated.
You're already an expert with the familiar Start menu, task bar, and desktop. Live tiles provide streaming updates of what matters most, instantly.
Windows 8.1 is designed to be compatible with the hardware, software, and peripherals you already own. And always-enabled updates help you stay current on features and security for the supported lifetime of your device.
Windows 8.1 gives you absolutely the best experience for doing what you do. Stay focused with easy ways to snap apps in place and optimize your screen space for getting things done. See your open tasks in a single view and create virtual desktops to gain space or group things by project, like Office apps for work and games for play.
Gaming just got even better with Windows 8.1. Not only do your existing games work great, but now you can play and connect with gamers across Xbox One and Windows 8.1 devices. From the best casual games to a new generation of PC gaming, Windows 8.1 is built for games you love.
Some users may afraid of uncustomed operation on Windows 8.1, but the fact is that it is a really easy and convenient experience with it. You will find it is quick to be familiar with and you can not live without it after a long-time using. No more to say, start a comfortable system from now!


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We get up, brush our teeth, take a bath and then what? Obviously, we put on our underwears and clothes and go to work. Right? But today we are talking about men's undergarments! To be fair guys do not know much about what are the various and the best type of undergarment which will be suitable for their body. Yes! The size matters so whenever you are buying undergarments for yourself feel free and honest to yourself. You should know about your body type very well.
Briefs ( Best for – men with larger thighs )
There is a reason that Christiano Ronaldo and David Beckham wear briefs! As they are the best choice for men with huge thighs. Briefs are also good for shorter boys as they expose your legs and makes you look taller.
Boxers ( Best for – Maximum Breathability )
Boxers are loose-fitting underwear with no support. But they give you more breathability than any other garment. Almost every boxer short have an open fly, allowing the user an exit route with maximum ease.
Also Read – The Dreamy-Eyed #Chaiwala From Pakistan Just Landed Himself A Modeling Contract
They are great for wearing regularly and even if you want to play a sport in them you can! So, they are super easy. Boxers are available in may kinds from trendy to slim-fit cuts.
Boxer – Briefs ( Best For – Taller Men )
Boxer – Brief are a combination of Boxer and Brief. Since the new style comings for men. This has become a "to go" style for men. This offers you protection and support. You can wear them with anything! You can wear them to the gym or can pair them with your denim.
Trunks /Hipsters ( Best For gym going guys or slimmer guys )
All pics @GQ
Trunks are a shorter version of a boxer- briefs. They are great for casual outings. This style also usually has a lower waistline than its boxer-brief counterpart, meaning that they sit lower on the hips.
So, when next time you go shopping make sure to keep everything and point in your mind. We hope these tips proved to be beneficial for you.
Now You Can Get the Latest Buzz On Your Phone! Download the PagalParrot Mobile App For Android and IOS


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Product information
The colour of Bronze inspires strength and wisdom, bringing wealth into our life. It helps us to trust our instincts and break destructive emotional patterns, so releasing irrational fear.
"I King Solomon speak to you through the wisdom of the Tree of Life. Its roots of illumination are held deep within your soul and the branches of the Higher Self which shoot up toward the heavens. Wisdom can only be gained through lessons learnt in life. Death and rebirth bring illumination along your soul's journey, so celebrate your life and the precious gifts it brings. Be the architect of your sacred temple, for in each lifetime there is much to be done if the ancient wisdom of The Tree of Life is to be accrued".
Ray 12 Bronze
The Ray of The Tree of Life.
Contains: Organic Alcohol, Spring Water.
Essential Oils: Cedarwood, Myrhh.
Gem Elixir: Petrified Wood, Septarian.
Instructions for use:
Gently shake the bottle. Spray around the Aura or the Sacred Space. You may use the Aura Spray as a perfume or mist a small amount onto a tissue and inhale the scent. Do not spray into the eyes. Not to be taken internally. Keep away from young children. Do not use if pregnant. Always consult a General Medical Practitioner or a qualified Aroma therapist if you have a medical condition and are unsure of using the products. Do not use if you have been diagnosed with Epilepsy. Keep in a cool place.
Technical specifications
|Fragrance Spray
|50ml Bottle
|Aura Colour
|Product Code:


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This authentic and delicious palak paneer takes just minutes to make! Using my pre-made onion masala, you can have this dish on the table in no time at all. I am sharing the EASIEST palak paneer recipe with you guys – and it is perfection. It's delicious, tastes like the real deal, and is literally… Read More
Instant Pot Coconut Rice
This south Indian coconut rice is so flavorful and delicious! It's also very easy to make in an instant pot! The grated coconut makes this pulao so fluffy and the curry leaves add great flavor. Coconut rice is a mild rice dish that's so good you can enjoy it on its own. This is a… Read More
Instant Pot Achari Aloo Baingan (Potato and Eggplant in Pickling Spices)
Achari aloo baingan is tangy, spicy and very flavorful. Potatoes and baby eggplants are coated in a blend of aromatic spices and cooked until perfectly tender. Whether you serve this as a side or a main course, it's bound to be the talk of the table. If you like Indian food, particularly north Indian food,… Read More
Instant Pot Kerala Chicken Stew
This mildly spiced Kerala chicken stew is a hearty soup made with chicken, carrots, potatoes and curry leaf spiced coconut milk, making this the ultimate Indian comfort food dish. If you've never had Kerala chicken stew before, think "a south Indian version of chicken soup." Everyone loves chicken soup. It's absolute comfort food on a… Read More
Instant Pot Baingan Bharta (Mashed Spiced Eggplant)
Baingan bharta, a classic Indian eggplant dish, takes minutes to make in an instant pot! You don't need to go to a restaurant to enjoy this dish, because it's so easy to make at home. If you haven't tried this Indian eggplant recipe before then you are in for a treat! It's almost surprising to… Read More
Instant Pot Italian Chicken and Tomato Soup
I have a super simple and super tasty Italian chicken and tomato soup coming to a bowl near you in 3…2…1! This instant pot Italian chicken and tomato soup is the perfect anytime soup! I'm talking a year-round soup – perfect for all seasons! It's hearty and filling and yet somehow also light and fresh.… Read More
Pineapple Shrimp Curry
Pineapple shrimp curry is sweet, savory and delicious! It's the perfect summer meal: quick to make, light and refreshing! Sweet pineapple perfectly balances the spices in this Indian-inspired shrimp curry. You can serve it with steamed basmati rice or cauli-rice or eat it by itself. This pineapple shrimp curry calls for fresh curry leaves, an… Read More
Instant Pot Sambar (Indian Split Pigeon Pea and Vegetable Soup)
You are going to absolutely love this recipe for sambar, a tamarind flavored lentil and vegetable soup! This recipe for instant pot sambar is so flavorful and tasty. It's the perfect soup to make any time of the year because it's fresh and light and filling all at the same time. This south Indian soup… Read More
Instant Pot Sookha Kala Chana (Spiced Brown Chickpeas)
Get ready to snack on some spiced brown chickpeas! Enjoy this sookha kala chana with roti, poori or on its own with a cup of chai. These masala-coated brown chickpeas are considered a "dry curry" and are often paired with Indian flatbread. I personally love snacking on them with a cup of creamy masala chai.… Read More
Instant Pot Aloo Methi (Potatoes with Fenugreek Leaves)
This aloo methi is salty, spicy, savory and full of flavor! You will love this super simple recipe for aloo methi. You can have it on your plate in literally 10 minutes, and most of that time is spent hands-off. This is why I love my instant pot because I can make fabulous food in… Read More
Instant Pot Ground Pork Vindaloo with Potatoes
This ground pork vindaloo is spicy, tangy and absolutely delicious! Think of this dish as spicy comfort food: the Indian version of meat and potatoes – with a bit of tang! This ground pork and potato vindaloo is the perfect weeknight recipe. It's really simple to make in an instant pot. I actually have another… Read More
Instant Pot Vegetable Biryani
This vegetable-packed biryani is a one-pot dish that's aromatic, flavorful and super tasty. You are going to love this vegetarian biryani recipe! It is so flavorful and aromatic! It's loaded with veggies like: carrots, bell pepper, potatoes, corn and peas. You can make this a vegan recipe too if you omit the ghee-coated cashews and raisins.… Read More
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Sorry but this item is out of stock
Please check back at a later stage.
This beautiful wind-up, musical jewellery box makes a lovely traditional gift for any little girl. The perfect place to keep all those special treasures!
Each large jewellery box includes a mirror and a spacious storage compartment with 4 drawers.
Dimensions: 19 x 12 x 14.5 cm
Suitable for ages 3+


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Tip: Upload Your Agenda documents to the /documents/agenda/ directory and it will show up here automatically.
Tip: Copy and Paste Your Upcoming Meeting Information in this area.
|Online ASHRAE
|Friday July 10
|3:00 PM - 4:30 PM Online
|Handbook & Research
|Tuesday July 14
|1:00pm-4:00pm Online
|Main Meeting
|All Times EDT
Tip: Upload your Minutes documents to /documents/meeting-information/ directory for them to show up here. The file names must include minutes as in "TC0709 draft Minutes Atlanta 20150628.pdf".
Tip: This section automatically generated from site Configuration file.
David Lee firstname.lastname@example.com
Tip: This section automatically generated from site Configuration file.
TC 6.1 is concerned with all aspects of hydronic and steam systems.
Tip: You can put any type of content in the following section.
Do you want to get involved in this committee's issues at the Society level? If so, read through the pages of this site, attend an upcoming meeting, or contact our Committee Chair.


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Carrying out
major works?
We can help by moving or
removing Openreach equipment
If you're a local authority, highway authority or utility company
There might be times when you come across our equipment or network during your work. It's important that you know how to work with this safely and without damaging it. We can help you by moving or removing it.
If you want us to move our network
If you need our network moved to make way for your project, we can help with:
- roadworks – new highways or alterations to existing road infrastructure
- bridge works – replacing bridge decks, waterproofing or completely removing or replacing structures
- public transport infrastructure – adding to and improving tram, railway and cycle routes
- town centre regeneration – new shopping centre projects or regenerating existing sites.
How to contact us
Call 0800 783 2023 option 1 or fill in this form to tell us more and get a quote.
If you want us to remove our network
First of all, tell us about the work you'll be doing. We'll work out what we need to do with our network and agree the best approach with you. This might involve removing our network kit from public or private land, then reinstalling it after your finish your project.
We can help with removing:
- ducting
- cables
- poles
- underground boxes including manholes
- overhead wires
- cabinets.
How to contact us
Call 0800 783 2023 option 1 or fill in this form to tell us more and get a quote.
Get help with our equipment
How to ask us to move or remove our kit
Everything you need to talk to us about it, and details on what will happen next.
Working with Openreach kit
Openreach manages the phone and broadband network in the UK. This includes any equipment which takes a service from a local exchange to a property. So that's things like poles, cabinets, drop-wires, brackets or bold fixings, lead-in cables, cleats and master sockets.
If you're working on the outside walls of a building (for example with double glazing, roofing, external wall insulation, satellite dishes, extensions and so on) you might come into contact with our equipment – lines, eyebolts, etc. We understand this could get in the way of your work, so you might need us to move or remove it.
How it works
Get in touch with us before starting this type of work. We'll:
- survey the property to check which equipment is there
- give you a quote for any work we need to do, like temporarily moving drop wires.
How to contact us
Call 0800 783 2023 or fill in this form.
So we can make sure you avoid any potential safety hazards, or damage to our equipment which could affect people's phone and broadband services.
Our equipment also has to meet strict guidelines to make sure it's safe – for example we need to make sure we install things at the right height.
If you're working on this or other similar large-scale works, take a look at our step-by-step guide.
For any other work on individual dwellings, including pebble dashing, double glazing, pointing, fascia boards/soffits, guttering, down pipes, roofing, building extensions and satellite dishes, call us on 0800 783 2023 or fill in this form.
Please note: you shouldn't cover our equipment with external insulation materials or other coverings without contacting us first to make the changes.
If there's any Openreach equipment on a property you're working on, we're the only people who can move it. So if you make any changes to our network, remove or replace fixings, remove drop-wires or lead-ins (temporarily or permanently) or do anything which affects it without telling us beforehand, this could be classed as trespass. We might then have to take action against you.
If something goes wrong because you or your contractors have altered, interfered or tampered with our network, you'll be responsible for any damage. We might then seek compensation from you. It could also mean you're investigated by the Health and Safety Executive (HSE) or even have criminal charges brought against you.
So it's important that you tell us about your project before you start work. Then we can give you permission to work on our network, advise you how to do it safely, or arrange to do the work ourselves.
If you don't need our network moved or removed but have questions about your phone or broadband, please contact the company that provides those services. They can check on the progress of any installation or repair work we're doing for you, including booking engineering appointments.
Useful links and handbooks
If you're working on external wall insulation or other similar large-scale schemes for local councils or housing associations, our step-by-step guide tells you everything you need to know.
Our "Identifying our equipment" guide has pictures and descriptions of our most common types of equipment, both past and present.
LN320 briefing for England and Wales
LN320 briefing for Scotland


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|Reviewed By
|Room Note
|Emeritus Account (29765)
|Mild to Medium
|Mild to Medium
There are almost no burleys to which I have been exposed which I didn't like. OSS is that one burley, unequivocally. Pleasnat pouch aroma, like BLWB. Packs well, with little spring. But, from the first bowl, the smoke was harsh. There was a mild, very mild flavor, seemingly like hot air. The taste reminds of the lesser grades of drugstore polybagged tobaccos. It burns well, a little wetter than I like While I have no problem with them, I would prefer PA as a standard go-to blend. This OSS is just too sweet and biting. I can hardly believe that this blend was a favorite of American troops overseas. OSS is uncharacteristic of the WWII and later periods. It has no, well, passion as a blend. There are far too many burleys available that provide a more satisfying smoke.
1 person found this review helpful.


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Shop the summer sales on Elysian's favorite sheets, pillows, mattress pads and duvets.
Ahhhhh, summer. Makes us want to enjoy the great outdoors. Sit in the sun. Dine al fresco. Do boot camp in the park. Nap in a hammock. But after all that outdoors stuff, we still take to our beds at the end of the day, and what could be better than a good night's sleep in crisp new linens? Summer is a great time to refresh your bedding. It's the kind of household chore that gets neglected during other times of the year, when back-to-school, holiday activities or sporting events take precedence. Best of all, summer is a fabulous time for online sales, and you can shop from the comfort of your beach chair. A few clicks, and that's another thing you can cross off your To Do list. Here are Elysian's absolute faves when it comes to sheets, pillows, mattress pads and duvets:
John Robshaw Stitched Sheets
30% off
Start with 300 thread-count pure combed cotton, add a delicate embroidered stitch across the top. Voila, bedding perfection!
$65, figlinensandhome.com
Sunham Amherst Sheet Sets
52% off
You're going to clamor to climb into these lush 400 thread-count cotton sheets each night. Available in 7 colors.
$66.99, macys.com
Sky Cotton Sateen Sheet Set
30% off
The key to a good life? We're not completely sure. But we think it has something to do with super soft, 500 thread-count cotton sateen sheets.
$139.99, bloomingdales.com
Whim by Martha Stewart Novelty Sheet Sets
60% off
What's not to like about a vibrantly-colored, 4-piece sheet set in 100% cotton percale featuring leopards and palm trees? We're stumped, because we love it!
$31.97, macys.com
Bluebellgray Watercolor Plaid Sheet Set
28% off
Available in pink and blue, the Watercolor Plaid is as cheerful as a Saturday morning when the kids and the puppy pile into your bed.
$59.99, bloomingdales.com
It's easy to underestimate the rectangular pouf that we lay our heads on at night. But our pillows play a critical role in how we sleep and whether we wake up rested in the morning.
The SensorGel Gusseted Pillow
50% off
Specifically designed for individuals who sleep on their backs and their sides, the SensorGel gusseted pillow is equipped with memory foam for comfort and support and a gel overlay for temperature regulation.
$59.99, macys.com
My Temperature Regulating Pillows
25% off
The name isn't very imaginative, but the patented Primaloft Thermobalance filling on My Temperature Regulating Pillow helps wick heat away from you in the summer and keep you cozy in the winter. Available in standard and king sizes.
$104.99 – $137.99, bloomingdales.com
My Featherdown Pillow
25% off
Not everyone likes to plunge into a plush down pillow, but for those of us who do, the Bloomingdale's Featherdown is hot commodity. Durably constructed with 600 fill power and a 325-thread count cotton shell, the Bloomie's Featherdown will not shed, flatten or fray.
$119.99, bloomingdales.com
Flair Asthma & Allergy Friendly Pillow
25% off
Severe asthma and allergies can have a serious impact on one's sleep and lung health. The hypoallergenic My Flair Pillow is filled with European down, and covered with 269-thread count Egyptian cotton, and German-milled damask.
$242.99, bloomingdales.com
Mattress Pads
Mattress pads may lack the thread-count sexiness of sheets or the star-billing of a duvet, but they certainly pull their own weight in the bedroom. A pad extends the life of your mattress by protecting it from contaminants, and also adds an additional layer of cushion and comfort to your sleep surface.
Coyuchi Organic Cotton Mattress Pad
10% off to new customers
Envelop your mattress in clean, breathable cotton that is 100% certified organic and free of chemical finishes and flame retardants.
$158, figlinensandhome.com
Bloomingdale's Ultimate Protection Mattress Pad
25% off
Waterproof and filled with antimicrobial fiber, the Ultimate Protection Mattress Pad is designed to keep stains and spills away from your mattress.
$96.99, bloomingdales.com
Ralph Lauren Lux-Loft Asthma & Allergy Friendly Mattress Pad
45% off
Protect your mattress from mildew, contaminants and odors with the Lux-Loft Pad which has been certified asthma and allergy friendly by the Allergy Foundation of America.
$109.99, macys.com
Pacific Coast Quilt Top Feather Bed
25% off
The Pacific Coast mattress pad is stuffed with fluffy Resilia feathers, which gently cradle your body's pressure points, contributing to restful sleep.
$216.99, bloomingdales.com
Bloomingdale's Dreamweave Mattress Pad
25% off
Protect your mattress while adding a layer of pillow-top comfort. The Dreamweave creates a breathable, water-resistant barrier against dust, bed bugs and allergens.
$85.99, bloomingdales.com
Duvet Covers
Years from now, when you look back on today, you might not remember which sheets you had on your bed, or what kind of pillow you used, but your duvet cover will be imprinted in your mind's eye forever. Might as well choose a print that you like.
John Robshaw Bita Duvet
50% off
Inspired by the bustling flower markets of India, the Bita design in lush purple and blue is an exciting design focal-point for your bedroom.
$125, figlinensandhome.com
Yves Delorme Air Bedding Duvet Cover
50% off
Beautiful indigo print on Egyptian cotton is designed to recall the movement of a kite.
$195, figlinensandhome.com
Ted Baker Flight of the Orient Duvet
40% off
Lush cherry blossoms and long-plumed birds set an elegant scene for your boudoir.
$179.99, bloomingdales.com
Ralph Lauren Luna Duvet Cover
59% off
Inspired by the eclectic bohemians of the American Southwest, the Luna Duvet has a tie-dyed pattern on one side, and a medallion print on the other.
$129.97, macys.com
Bluebellgray Duvet Cover
28% off
A sweeping watercolor rendition of bluebell flowers entwined with yellow honeysuckles.
$139.99, bloomingdales.com


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Golf de Bordeaux Pessac
Golf de Pessac is located just 15km south-west of Bordeaux and just 5 minutes from the airport, in the heart of a pine forest. The course is just a few minutes from one of the largest vineyards in Bordeaux.
Golf de Pessac is a flat 18 hole course featuring wide pine-lined fairways, water hazards and quality contoured greens. The Restaurant "Le Master" is open everyday for lunch.
The Golf Club also features a number of facilities such as 2 conference rooms vith views of the course, putting and chipping greens and an 80 bay driving range where there are pros available to give golf lessons.


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With the fall semester getting underway Sept. 2, Daemen College hosted a variety of campus activities for returning and incoming first-year students, including Fall Convocation to welcome more than 550 new students to the college community and to celebrate the start of the new academic year.
"The most important ability you will acquire in your college years is the ability to think critically and analytically about the world," Daemen President Gary A. Olson said in his address to students at the all-campus event on Sept. 4. "As college-educated individuals, you will have the ability and the responsibility to always exercise your critical thinking skills.
Winner Played IGT Penny Machine in Homage to Actor Richard Attenborough
Catholic Charities of Buffalo has appointed two new members to its leadership team. Meichle Latham has been named Director of School Based Services and Maria Picone has been named Director of the Family and Community Services Department, formerly known as the Metropolitan District Service Department.Dennis Walczyk, Catholic Charities Chief Executive Officer, said, "We are pleased to promote Maria and Meichle to these leadership positions, and look forward to the expertise, passion, and energy they will bring to their new and increased responsibilities."As Director of School Based Services, Latham is responsible for overseeing the organization's services currently delivered to Catholic, public and charter schools in Erie and Niagara counties. She also will establish and maintain connections with educational partners and work to expand services to schools not being served.
On Friday, September 5th, 2014, the Valley Community Association will host their fourth annual "Halfway To St. Patrick's Day Party" at Buffalo River Fest Park, located at 249 Ohio Street, Buffalo, New York. The event will run from 7pm to 11pm and will feature the local Irish band "The Left Overs".
"The Left Overs" have established a following in Buffalo and throughout Western New York for over a decade. With music ranging from popular drinking songs to the historical and poignant rebel songs of Irish past, "The Left Overs" offer a large variety of tunes and ballads. The band was founded by Jerry Shea and Pat Gerken, on the premise that good music will always bring people together. "The Left Overs" are Jerry Shea, Pat Gerken, Elizabeth Shea, Ryan Young, Dave Pruski, Greg Kent, and Tim Ellis.
Germany native brings 25+ years of experience at Marriott International propertiesthroughout the U.S. and Germany, as well as resorts in Bermuda and Dubai
Berardi Immigration Law is pleased to announce that Jennifer Behm has been named Partner.
Behm joined Berardi Immigration Law as an Associate Attorney in 2011. She advises multinational companies and individual clients in all aspects of immigration law, including nonimmigrant visas, NAFTA matters, family and employment-based green cards, criminal waivers, consular processing and naturalization. A native of Phoenixville, PA, and current resident of Amherst, NY, she received her Juris Doctor from the SUNY Buffalo Law School in 2011 and a Bachelor of Arts in English Writing from the University of Pittsburgh in 2008.
Two local veterans have been awarded scholarships through the Gary L. Valeri Scholarship Program by The Resource Training Center of Amherst and S.E.R.V. Niagara. The scholarship, named after the former husband of S.E.R.V. Niagara's founder who lost his long battle with addiction, will help train veterans to work as Credentialed Alcohol and Substance Abuse Counselors (CASAC).
Persistence Preperatory Academy
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02:00pm, Saturday, 30 March 2019
03:00pm, Saturday, 30 March 2019
Tour Guide:
Matteo Boldrin
Yianni Kattirtzis
Duration: 1 hours
Time: 14:00 - 15:00
Start: Outside 2 London Wall Place
Getting There: Moorgate or Barbican underground stations
The scheme comprises two office buildings surrounded by extensive public realm including a series of public gardens and reimagined elevated pedestrian walkways to link the neighbouring Barbican with the City of London. The two buildings enclose the new London Wall Place gardens. 1 London Wall Place delivers 310,000ft2 of new state-of-the-art office and trading facilities, and a series of nine roof terraces over 13 storeys.
With half of the site dedicated to public realm, London Wall Place has created a new destination for the City. The public realm is formed of a series of pocket gardens for people to discover that, together with the adjacent Salters' Hall Garden and soon-to-be-completed St Alphage Garden, delivers more than 1.5 acres of public space and over 780m2 of green walls across multiple terraced levels. The walkways, which include four bridges that cross London Wall, Wood Street, Fore Street and Fore Street Avenue, cover 350m and house a new raised garden.
Tour Guides:
Matteo Boldrin
Matteo completed his architecture studies in Milan and Delft and qualified as an architect in Italy, after spending three years living and working in Australia. He joined Make in 2015, the same year he qualified in the UK. Matteo was the project architect for London Wall Place. Following the completion of London Wall Place Matteo has worked on further office projects in London, including competition for a pair of commercial towers as part of a larger masterplan in the city centre and a mixed used masterplan for a key regeneration site in Bratislava.
Yianni Kattirtzis
Yianni joined Make in 2006 and qualified as an architect in 2014. During his time with the studio he's contributed to a number of high profile developments such as 80 Charlotte Street for Derwent and was the project architect on London Wall Place. From 2017 – 2018, Yianni was based at Make's Sydney studio working on a prestigious hotel and residential scheme and a boutique apartment project. Yianni is a visiting lecturer at Greenwich University.


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Below is the EURUSD Technical Chart currency pair explained with technical indicators.
EURUSD Technical Chart
I've used Doda Donchian, Doda-Bollinger Bands, Ichimoku and ADX Candles in this chart. Time frame used is H4.
As clearly visible in above image, Doda Donchian indicator gave Buy signal @1.17312 and it gave profit of apporox. 68 pips by then.
The same call was confirmed by Doda-Bollinger bands too.
But shall one take such call?
Let us examine in detail.
The BUY signal was given when EURUSD was trading below Ichimoku cloud. That means such calls are risky ones. One should NOT take any Buy call when a currency pair is trading below Ichimoku cloud.
Currently, EURUSD is trading inside Ichimoku cloud – which is "No trade" zone.
Although with current pattern, EURUSD is likely to touch 1.18425, where it will face tough resistance. But still, I would wait to tarde this currency pair EURUSD either above Ichimoku cloud or below this cloud.
Support Levels for today are:
Resistance Levels for today are:
Stop loss should be @1.17728
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Nashville, TN -- DelFest, produced by McCoury Music & High Sierra Music, is pleased to announce the following lineup additions to the 11th annual DelFest, which takes place May 24-27 at the beautiful Allegany County Fairgrounds in Cumberland, Maryland. The thirteen acts announced today, paired with the festival's initial lineup, solidify DelFest as the premier live music event for fans whose musical tastes span the width of bluegrass, Americana, and improvisation-- fitting considering its namesake, Del McCoury, is the patriarch of the modern day string band.
Trey Anastasio Band, Gov't Mule, Bela Fleck, Leftover Salmon, Hot Rize, and The Infamous Stringdusters are just a few of the fantastic acts coming to the family reunion in Cumberland for the 10th Annual DelFest. Teen, Kids, On-site RV, Dry RV, Vehicle, and DELuxe packages went on sale Tuesday, January 10th so hurry while they're still available. This 10th Anniversary event takes place May 25-28 in Cumberland, Marylannd.
DelFest 2014 will once again be held at the beautiful Allegany County Fairgrounds in Cumberland, MD (2.5 hrs from Baltimore and DC). The festival originated from the desire to create a family-friendly music festival celebrating the rich legacy of McCoury music while creating a forum for world-class musical collaborations and to showcase fresh new talent with a down-home feeling. Produced in association with High Sierra Music, the 7th Annual DelFest will again offer a quality festival experience stamped with the unique McCoury touch. Personally chosen by Del, the Allegany County Fairgrounds in Cumberland, MD served as the perfect location for DelFest--nestled along the Potomac River in the scenic Appalachian Mountains, the Fairgrounds are convenient to four major airports and easily reached by rail or road.
Nasvhville, TN -- The hardest part of any festival is continuing to not only march out strong lineups year after year, but marching out a lineup that the fans feel is the strongest yet. DelFest continues to rise to the challenge, and once again, organizers feel like they are on track to give the fans exactly what they want. DelFest takes place Memorial Day Weekend -- May 22 to 25, 2014 in Cumberland, Maryland.
Nashville, TN -- Anticipation for the sixth Annual DelFest has ratcheted up significantly in recent weeks. Whether it's from the spring weather in the air, the additional line-up announcements, or the faithful fans just not able to wait much longer, it's safe to say that this year's festival can't come soon enough.
The initial lineup is here! Make plans with friends and family now to join the McCourys on Memorial Day weekend in beautiful Cumberland, MD for a festival experience like no other! The 6th Annual DelFest just announced their lineup for the four-day Memorial Day weekend music festival in Cumberland, Maryland.
The Tri-State Community School for the Arts and WFWM Public Radio will offer two scholarships to the DelFest Academy 2013. Scholarships are awarded annually to talented and motivated students who are involved in bluegrass music and who demonstrate a need for financial assistance.
Nashville, TN -- All these sunny, mild winter days we've been experiencing probably have many of you already sorting out your camping supplies, ready for the festival season to begin. While we still have a few months to wait, DelFest will be here before you know it. So make your plans now, and grab your four-day passes before prices increase at midnight March 5th.
Nasvhville, TN -- Through their many comments on Facebook and other social media sites, DelFest bluegrass music fans have made it clear that they are excited about the already announced DelFest lineup. But that was just a sneak preview of what has shaped up to be one epic show. Additions to the lineup include the versatile Bela Fleck (playing with members of the Travelin' McCourys and Danny Paisley, as well as a set with the Marcus Roberts Trio), festival favorites Railroad Earth, Leftover Salmon, and Greensky Bluegrass.
Warm summer sun and the sweet sounds of bluegrass are just a few months away! If you haven't yet purchased your tickets, please note that our first discount deadline is Monday, January 30th. A limited number of adult 4-day passes are still available for $120 through Monday or while the quantity lasts. Adult 3-day passes, Teen passes, Kids 3-day and 4-day passes, DELuxe Experience Packages, RV passes and on-site parking passes will all remain at their current price levels. On-site camping is included in the price of your multiple-day DelFest pass. Be an early bird and save money!
Just in time for holiday gift-giving, discounted early bird passes, parking passes, DELuxe Experience Packages, RV passes, and DelFest Academy passes are on sale now! Cards are coming together for an exciting 2012 lineup, but we're not quite ready to reveal our hand. Stay tuned for our initial lineup announcement!
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What Role Does Personality Play Regarding Satisfaction in our Later Years of Life?
Study examines well-being of senior citizens
Kiel/Berlin. People state that conscientious, caring and social conduct as well as less nervous or anxious behavior are characteristics of more satisfied people. However, this changes later in life. For example, a certain amount of anxiety has less negative effects on life satisfaction later than in younger years because it may encourage older people to pay more attention to potential risks and to take special care of themselves. This is shown by a study published in the Journal of Personality and Social Psychology by scientists from the Leibniz Institute for Science and Mathematics Education in Kiel, the Max Planck Institute for Educational Research, Pennsylvania State University and Humboldt University Berlin.
A person's personality is closely related to their circumstances and affects how satisfied they are with their life. For psychologists personality consists of the unique patterns of thought, behavior and experience that make up a person. They distinguish how neurotic, extraverted, open to new experiences, compatible and conscientious a person is. Previous studies have shown that people who are less neurotic, that is, less anxious and nervous, and at the same time more extraverted and compatible in their lives are more satisfied. But does this apply equally to all phases of life, especially to the last years of life?
While most previous studies concentrated on middle age, the scientists evaluated data from more than 600 former respondents of the longitudinal study Socio-Economic Panel (SOEP) who had already died and who were between 50 and 101 years old at the time of their death and who had provided information on their health and well-being once a year in the ten years before their death.
As expected, the findings show that personality is also related to life satisfaction in the last years of life. What is surprising, however, is that some personality traits that are positively linked to well-being in earlier years of life are less positively or even negatively related to the development of life satisfaction at the end of life. The results are particularly interesting, as the last ten years of life have often been marked by severe losses, for example in health and mental fitness, as well as by a drastic decline in well-being.
Thus, low neuroticism - i.e., the tendency to be less anxious and more emotionally stable - has a less positive effect on well-being in the last years of life than in earlier phases of life. Similar findings were found for extraversion and tolerability: Particularly extraverted and compatible persons reported a higher life satisfaction a few years before their death, but then showed a greater decrease in well-being shortly before their death, so that at the end of life they were just as or even less satisfied than less extraverted or compatible study participants. "The findings could indicate that elder and very elderly people increasingly benefit from focusing more on particularly close social relationships and also more on their own needs, instead of investing a great deal of energy they no longer have in relationships with a broad circle of friends" says first author Swantje Müller, research assistant at the Leibniz Institute for Science and Mathematics Education in Kiel, who conducted the analysis during her time as a doctoral student at the Max Planck Doctoral School LIFE.
Interestingly, however, the effect of extraversion was only seen in women, while men's life satisfaction was not related to their extraversion. "This could indicate that social components are more important for women than for men," says Jenny Wagner, formerly at the IPN in Kiel and now professor at the University of Hamburg. Furthermore, it becomes clear from the results that the personality trait conscientiousness, which in earlier studies was frequently associated with a healthy and happy life, still positively affects well-being in later years.
**Original Study**
Mueller, S., Wagner, J., Wagner, G. G., Ram, N., & Gerstorf, D. (2018). How far reaches the power of personality? Personality predictors of terminal decline in well-being. /Journal of Personality and Social Psychology/. doi: 10.1037/pspp0000184


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"Fleabag" was created by and stars British writer and actor Phoebe Waller-Bridge.
While the show is not overtly autobiographical, Waller-Bridge draws heavily on her own experiences and those of her friends.
The title character — known only as Fleabag — is a very clever woman who runs a little cafe. She's not terribly successful in life or love, and when the series starts, we find out her best friend has recently died.
Fleabag often breaks the fourth wall and speaks directly to the audience — a part of the performance that Waller-Bridge used when "Fleabag" started as a solo show at the Edinburgh Fringe Festival in 2013.
But you quickly get the feeling that maybe Fleabag is a little too glib — that her constant humor is masking some hard, and heartbreaking, truths.
We spoke with Phoebe Waller-Bridge recently. I was curious about the origin of the name Fleabag.
Interview Highlights:
On why she picked the name Fleabag:
I didn't want to give her a regular name because I wanted her to feel like an everywoman. But then my mom called me and referred to me as Fleabag on the phone because that's my family nickname. In that moment I was like, "Oh no. That's such a great name for this character" ... I've always associated it with being affectionate, which is probably why I gave it to the character, which of course, in the cold light of day, is a horrible word with really dark connotations. I thought it was good because it bought me a subtext to the character so the audience's interest was peaked in a different way. When you first meet her I hope you feel like she's just a regular person with a naughty sense of humor. She's not a fleabag. So I thought it might add a bit of texture.
On the review of her 2013 one-woman show of Fleabag that said she might go to hell for performing it:
I was thrilled with that. It's funny because she talks about sex a lot — and in the TV show as well, but in the play, because it's just reported. It's just the three days of her life reported to an audience. It's just me on a stage. And how much she dismisses and laughs at her own sexual experiences without putting too much weight on them or the impact that they have on her own life seems kind of minimal at the time — I think that just really seemed to shock people, the kind of carelessness with which she opens up the secrets of her sexual history. It seemed very shocking, which I was thrilled with as well.
On scenes that seem to be the worst case scenario:
Oh yeah. I sort of get off on writing the worst case scenario of anything even on the small social existence, but also on the bigger scale. Even if I get a kernel of an idea of, oh wouldn't it be really humiliating if this person said this to me right now? Then I'll again have to see the funny side, write it down and turn it into a TV show. It's my way of dealing with it, I think.
On Fleabag breaking down the fourth wall and her former friendship with her late friend, Boo:
It's the absence of someone who understands her and someone that she feels safe with is mixed in with that relationship. That complicity that she commands with the audience is one that she would have done with Boo. But there's also another level to the relationship to the audience when she's got a front up and it's for the sake of the audience. So it's not so much that the audience is experiencing the true inner monologue of this character. The audience [members], I hope, are feeling like they met a character who's still putting on a bit of a show for them. So the relationship between Fleabag and the audience through the series, I was trying to structure it so that relationship changes and evolves and eventually breaks down as well as the other ones that actually populate her world. So she's kind of a mix of a best friend and also someone that she can show the best sides of herself to and have to show her strength to.
On describing Fleabag's sex, intimacy and inner fulfillment:
On one level, I feel like she has a really healthy relationship with [sex]... She has a sexual appetite that she's not embarrassed by. And that to me is just like me and most of my friends. That didn't seem so surprising or shocking and I think that's probably why so many women have responded to that.
A lot of people were saying, "Oh, my God this character is totally sex-obsessed." So above and beyond the natural appetite she's got, I think she chases it for other reasons, mainly validation, control, power, being able to understand that when she sees desire in somebody's eyes then she is in control of that microcosmic situation in her world and in her life. Everything else can fall away and now she has control in her life for that one moment. I think that can be very true of women.
When I was in my early twenties, I certainly felt like that was really important to be considered sexually desirable or valuable in some way. And then talking a lot with my girlfriends at the time, it seemed like it was a burden that was being carried as well as something that was sort of fun, exciting and pleasurable. And the mixture between the two was actually leaving a kind of broken relationship with the good things about sex and also the reasons that people are chasing it. Like she said in the second episode — Fleabag says that she's completely obsessed with sex and she can't stop thinking about it and she loves every single aspect of it except for the feeling of it. That's the catch with her.
On the scene where Fleabag pleasures herself to the President of the United States:
I don't think I'm the first person to have that leap of imagination! It's actually a kind of truncated version of a scene early on in the stage play when she's lying in bed and there's a number of things that she's trying to watch to distract her from wanting to watch porn. She is saying, "I'm not going to watch porn, I'm not going to watch porn."
Then she decides she's going to watch a film and it's got Zac Efron in it and she's like, "I'm gonna stop watching this film." She stops watching the film, tries not to watch porn and then she's like, "I'm gonna watch the news, I'm gonna do that because that is going to completely take my mind off everything and it's going to be boring and informative and it's going to make me a better person."
Then the first thing she clicks on is Obama and she's like, "Oh f---. I'm just going to wank now."
So he just tipped her over the edge. And then basically because everyone said that was the juiciest bit of the joke, we just took Obama out and put him in the show.
On there being a lot of sex talk but no nudity:
Yeah that was really important that for me that it was all about the language of it. I think if she's talking so explicitly and then you see the explicit act that she's talking about, I'm not sure what's left for the audience.
For me it was more about language and the power of it and the fact that she's looking straight down the barrel in a close up. That kind of intimacy with the audience and that kind of openness about sex and that sexual candor — it's not just about her being honest. It's also about her commanding attention from the audience. She's like, "Yeah I'm just going to say that. I've said it, you've listened to it and I bet you sort of know what I mean."
It's about her control. That's why I kept telling myself, if she's the person controlling the camera — if she's the person telling the story — she wouldn't necessarily want you to be right up there.


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Anger at meeting as villagers oppose access route proposal
PUBLISHED: 22:03 11 December 2017 | UPDATED: 11:57 12 December 2017
Plans to use the main road through Trowse as an access point for a major construction project have been strongly opposed by villagers at a parish council meeting.
Permission has already been granted for 75 homes to be built in the Arminghall Settlement, however, the planned access route has changed.
Originally, access to the site was planned via White Horse Lane, where an access junction is currently being built by Norfolk Homes.
But as the junction is not yet complete, the Arminghall Settlement is now seeking permission to use the main road in the village, The Street, enabling them to access the site via Hudson Avenue.
Sarah Simpson, director of transport and planning at Royal HaskoningDHV, said the plan was not ideal, but was necessary.
She said: "There is a lot of pressure from the council (South Norfolk) to build and develop in this area and we can't wait for the White Horse Lane access road as our permission will expire. This route is not our preferred route, but we will ensure it satisfies the Highways Authority."
The Arminghall Settlement is proposing it accesses the site through the village on a temporary basis, until the first 45 units are complete.
However, villagers argued that the route is neither safe or suitable.
A planning solicitor suggested the Arminghall Settlement was jeopardising the safety of villagers to avoid negotiating a price for access via Norfolk Homes' junction on White Horse Lane.
He said: "You are dodging negotiating. We are not opposed to the development of the new homes but we cannot accept this proposal. Construction traffic will become de facto in the village and the road is completely unsuitable."
Many others voiced their concern that the roads were not suitable for heavy goods vehicles, saying the village was a conservation area full of children.
Mrs Simpson explained that traffic management systems would be put in place – an explanation that was greeted with loud groans of disapproval.
A spokesperson for the Arminghall Trustees said: "We remain committed to working closely with the local community and the parish council to try and resolve any issues surrounding the site."
If you value what this story gives you, please consider supporting the Norwich Evening News. Click the link in the orange box above for details.


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"The most exciting part about PLINY is that it brings together two fundamental areas of computer science, programming languages and machine learning," said CS research scientist Vijayaraghavan (Vijay) Murali. "Swarat Chaudhuri had been presenting papers on programming languages at some of the same conferences where I was presenting, but I had not considered a collaboration until a mutual friend suggested it."
Murali was completing a Ph.D. in Singapore and looking for post-doctoral opportunities in the United States, when a friend mentioned the work of the associate professor of CS at Rice University.
Murali was excited to learn of PLINY, the four-year, $11 million project funded by the U.S. Defense Advanced Research Projects Agency (DARPA) and received by Rice in 2014. The project is aimed at developing "autocomplete" and "autocorrect" code for programmers, much like the software that completes search queries and corrects spelling on Web browsers and smartphones. Murali joined Rice as a post-doc.
"Working on your Ph.D. is like going down a deep well. You pick a topic and go deeper and deeper for four or five years. You are an expert in that area. Graduating is coming up out of that well, and it's refreshing to be exposed to another area," Murali said.
He enjoys applying his knowledge of programming language, acquired as a doctoral student, to problems in a new realm. "The wonderful thing about PLINY is that it brings together two fundamental areas in CS, and you can apply the techniques and solutions in one field to solve problems in the other."
Because Murali had focused on formal methods of programming languages, he felt like a newcomer to machine learning. Software engineering has permeated most industries, so it is essential to the future success of both advanced and developing countries to raise up an adequate workforce of programmers. A major hurdle to developing new programmers is the discovery and application of best practices. PLINY could help overcome the challenge by helping bring an intelligent but untrained workforce up to speed in basic programming roles.
"If you want to make programming accessible to non-programmers," Murali said, "you need to create quick avenues to success that foster a sense of learning and accomplishment while at the same time delivering solutions."
By mining huge repositories of software programs in open-source systems like GitHub, the PLINY project can be used to learn automatically how software is being written. "GitHub is a gold mine for us," Murali said. "Our goal is to mine repositories like this to learn how software is being written in the real world and what the common practices are."
PLINY could be adapted to learn how specific rules apply to particular domains, such as Android apps. "When new Android developers want to write an app, they can apply PLINY's knowledge to easily follow the 'unwritten rules of the real world' and write better code the first time," Murali said.
PLINY can also identify bugs as software is developed, and repair errors in the programs. Murali feels a sense of accomplishment because the system he developed to learn how software is being written has already been successfully applied. He ran his system on Android apps to make it automatically learn how they were written, then applied that knowledge to newer Android apps offered on GitHub and installed on his own phone. He found a bug.
"The first milestone moment came when I was able to visualize in the phone app the same error that my system had discovered in the app's source code. I contacted the developers and they were appreciative. It turned out to be a user-interface bug. Since then we have also found other insidious bugs in real apps, ranging from bluetooth usage to cryptographic encryption."
For more information on the PLINY project, a collaboration between Rice University, the University of Texas at Austin, the University of Wisconsin-Madison, and GrammaTech, see: http://pliny.rice.edu
Vijayaraghavan "Vijay" Murali began working as a research scientist in the CS department in 2015.


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- Variety: Riesling
- Key Features Sweet wine, Unoaked, Vegetarian and Vegan,
- The Wine
A very pale yellow-green with an elegant nose of lime and white flowers. The palate is immediately assailed with its rich creamy texture and masses of rich ripe fruit, with exotic fruit flavours, hints of peaches and passion fruit. Just a hint of honey on the finish followed by a restrained yet pleasing mineral acidity.
Ben says (July 2016): The way that wine develops with age is always fascinating. I am leaving the original notes above as the comparison is worthwhile. The very pale colour has been transformed into a deep Mediterranean sunset gold which is utterly beautiful. The white flowers have been superceded by honey made from their pollen but the lime remains, as does enough petrol to confirm the Riesling grape. The texture is still rich and creamy and the fruit flavours have matured into a gorgeous amalgamation of sensory pleasure with more of the white flower honey drizzled on top. The finish is long and exquisite.
This is amazing!
Ben says (November 2018): Never judge a wine by the first sip! On the first sip there was a slight doubt as to whether this wine was still as good as previously. Thankfully, from the second sip onwards it is! The notes from 2016 stand firm and it remains a beautiful wine.
- Vintage Information
Product code ZIMMERMANNAUSLESE Bottle Size 0.75 Winemaker Weingut Anton Zimmermann Featured Themes Mature Vintages Sweet Yes Style White, Single Variety, Sweet, Still Variety Riesling Key Features Unoaked, Vegetarian and Vegan Country Germany Region(s) Mosel Ripeness Auslese Closure Natural Cork Vintages 2006 Last Tasted Jul 21, 2016 name: Weisenstein Riesling Auslese vintage: 2006 size: 0.75 product code: [4930087] stock: 3 in London Warehouse
3 at Alpine Wines House
alcohol: 12.5 last checked in: 2018-11-20
- Reviews
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These cool and classy pens in soft colour tones really pushed all our buttons.
Beautifully made, great design, high quality, compact, fits easily into a pocket or handbag and lovely to write with.
What more could you ask for?
Gell roller ink is black 0.7mm. Length of pen 105mm closed / 130mm open. Acrylic barrel. Comes with gift box.


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To paraphrase John Donne – no Salesforce implementation is an island. Typically, Salesforce is part of a company's systems "continent" and the need to integrate it with other applications is a common one.
An integration can be as simple as the requirement to update a Salesforce record from an external system or as complex as creating an order in a remote system after it's created in Salesforce and waiting for a response from that remote system. Each integration scenario is completely unique, but there do exist archetypes or patterns for integration.
That's where Integration Patterns and Practices comes in. This guide is new in Winter '13, and it addresses these common integration scenarios:
In addition to these patterns and best practices, you'll also find a matrix to help you select the pattern that best matches your scenario based on your source and target systems, whether you're integrating processes or data, and whether you need synchronous or asynchronous integration.
This document was created by experienced Salesforce field architects and implementers, and contains the patterns and best practices that they've developed from working with Salesforce integrations over the years.
If you think you'll be integrating Salesforce with at least one other application or system, check it out!


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Call Today 1-800-533-3356
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- MRC X-ray tube eliminates waiting times between scanning sequences.
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