text: Ancylostoma ailuropodae n. sp. (Nematoda: Ancylostomatidae), a new hookworm parasite isolated from wild giant pandas in Southwest China Abstract Background: Hookworms belonging to the genus Ancylostoma (Dubini, 1843) cause ancylostomiasis, a disease of considerable concern in humans and domestic and wild animals. Molecular and epidemiological data support evidence for the zoonotic potential among species of Ancylostoma where transmission to humans is facilitated by rapid urbanization and increased human-wildlife interactions. It is important to assess and describe these potential zoonotic parasite species in wildlife, especially in hosts that have physiological similarities to humans and share their habitat. Moreover, defining species diversity within parasite groups that can circulate among free-ranging host species and humans also provides a pathway to understanding the distribution of infection and disease. In this study, we describe a previously unrecognized species of hookworm in the genus Ancylostoma in the giant panda, including criteria for morphological and molecular characterization. Methods: The hookworm specimens were obtained from a wild giant panda that died in the Fengtongzai Natural Reserve in Sichuan Province of China in November 2013. They were microscopically examined and then genetically analyzed by sequencing the nuclear internal transcribed spacer (ITS, ITS1-5.8S-ITS2) and mitochondrial cytochrome c oxidase subunit 1 (cox1) genes in two representative specimens (one female and one male, FTZ1 and FTZ2, respectively). Results: Ancylostoma ailuropodae n. sp. is proposed for these hookworms. Morphologically the hookworm specimens differ from other congeneric species primarily based on the structure of the buccal capsule in males and females, characterized by 2 pairs of ventrolateral and 2 pairs of dorsolateral teeth; males differ in the structure and shape of the copulatory bursa, where the dorsal ray possesses 2 digitations. Pairwise nuclear and mitochondrial DNA comparisons, genetic distance analysis, and phylogenetic data strongly indicate that A. ailuropodae from giant pandas is a separate species which shared a most recent common ancestor with A. ceylanicum Looss, 1911 in the genus Ancylostoma (family Ancylostomatidae). Conclusion: Ancylostoma ailuropodae n. sp. is the fourth species of hookworm described from the Ursidae and the fifteenth species assigned to the genus Ancylostoma. A sisterspecies association with A. ceylanicum and phylogenetic distinctiveness from the monophyletic Uncinaria Frölich, 1789 among ursids and other carnivorans indicate a history of host colonization in the evolutionary radiation among ancylostomatid hookworms. Further, phylogenetic relationships among bears and a history of ecological and geographical isolation for giant pandas may be consistent with two independent events of host colonization in the diversification of Ancylostoma among ursid hosts. A history for host colonization within this assemblage and the relationship for A. ailuropodae n. sp. demonstrate the potential of this species as a zoonotic parasite and as a possible threat to human health. The cumulative morphological, molecular and phylogenetic data presented for A. ailuropodae n. sp. provides a better understanding of the taxonomy, diagnostics and evolutionary biology of the hookworms. Keywords: Ancylostoma ailuropodae n. sp, Ailuropoda melanoleuca, Morphology, Phylogeny, Ancylostomatidae Hookworms (Nematoda: Ancylostomatidae) are one of the most common soiltransmitted helminths, causing serious iron-deficiency anemia and protein malnutrition in humans and domestic and wild mammals [1–3]. Both major genera Ancylostoma (Dubini, 1843) and Necator Stiles, 1903, relegated to two distinct subfamilies, are responsible for morbidity and socioeconomic burdens [4]. Unlike species in the genus Necator, most Ancylostoma hookworms are considered to be of greater medical and veterinary importance because of distribution, prevalence, and multiple zoonotic species [2]. Currently there are fourteen valid species identified in the genus Ancylostoma that are often considered in the context of the range of hosts that are typically infected. For example, the 'anthrophilic' form is limited to Ancylostoma duodenale (Dubini, 1843) which principally infects humans. 'Anthropozoonotic' forms, capable of circulating among free-ranging wild hosts, some domestic hosts and humans include Ancylostoma caninum (Ercolani, 1859), Ancylostoma braziliense Gomes de Faria, 1910 and Ancylostoma ceylanicum Looss, 1911. Other species, including most of the recognized diversity in the genus are considered to be primarily of veterinary importance, including Ancylostoma tubaeforme (Zeder, 1800), Ancylostoma malayanum (Alessandrini, 1905), Ancylostoma pluridentatum (Alessandrini, 1905), Ancylostoma paraduodenale Biocca, 1951, Ancylostoma kusimaense Nagayosi, 1955, Ancylostoma buckleyi Le Roux & Biocca, 1957, Ancylostoma taxideae Kalkan & Hansen, 1966, Ancylostoma genettae Macchioni, 1995, Ancylostoma protelesis Macchioni, 1995, and Ancylostoma somaliense Macchioni, 1995 [5, 6]. It is noteworthy that nearly all of these species can also be found in wildlife, such as A. duodenale in Crocuta crocuta (Erxleben); A. caninum and A. braziliense in Acinonyx jubatus (Schreber) and Canis mesomelas Schreber; A. ceylanicum in Canis lupus dingo Meyer; A. paraduodenale in Leptailurus serval (Schreber); A. malayanum in Ursus thibetanus G. Cuvier; A. pluridentatum in Puma concolor coryi (Bangs); A. kusimaense in Nyctereutes procyonoides viverrinus Temminck; A. taxideae in Taxidea taxus taxus (Schreber); A. genettae in Genetta genetta (Linnaeus); A. protelesis in Proteles cristata (Sparrman); and A. somaliense in C. mesomelas [5–12]. Although a diverse assemblage of carnivorans is recognized as hosts for Ancylostoma, only one species had been documented or described previously among the Ursidae [7]; species of the distantly related Uncinaria Frölich, 1789, are considered typical in ursine hosts [13]. Recent molecular-based genetic and epidemiological investigations have shown that among certain wild or domestic animal-derived species of Ancylostoma, A. ceylanicum is becoming the second most common hookworm found to infect and complete its life-cycle in humans [12, 14–18]. Similar transmission and crossinfection cases have been reported for other congeneric species, notably A. caninum [12, 19, 20] and A. braziliense [12]. Such situations highlight the public health significance of hookworm infection and the necessity to assess their prevalence and distribution, and to identify their wildlife hosts. This has become especially important for wildlife hosts that may have recently adapted to the human environment due to rapid urbanization [14, 21] leading to increased interactions with people in conservation centers and zoological gardens constructed for endangered and valuable animals [22]. Regrettably, little attention has been broadly paid to the species of Ancylostoma because of a limited understanding of their diversity, abundance and distribution and the difficulty in etiological and epidemiological sampling in the wild [12, 14]. The giant panda, Ailuropoda melanoleuca (David), one of the most endangered and rare species of China, is regarded as one of the preeminent species for wildlife conservation in the world. Higher taxonomic status for these enigmatic carnivorans had been unresolved, until relatively recent decisions that unequivocally placed giant pandas among the Ursidae (e.g. [23–26]). Wild giant pandas currently inhabit six small mountain ranges of China i.e. Qinling, Minshan, Qionglai, Daxiangling, Xiaoxiangling and Liangshan (Fig. 1), with an estimated population size of ~1,864 [27–30]. Since the 1950s, numerous natural reserves, conservation centers, research bases and zoological gardens were specifically established by the Chinese government to protect this threatened species [31]. Some of these wild giant pandas have become closely associated with humans as they are housed for artificial breeding and conservation and biological investigations. Also, some pandas have been displayed publically as the 'messenger of peace and friendship' around the world [32]. Although ecological, genetic and etiological studies have shown that the panda faces the threat of extinction due to habitat loss, poor reproduction and low resistance to infectious diseases [33, 34], recent surveys strongly indicate that parasitic infections represent the leading health threat to giant pandas of China [35–40]. Hookworm parasites have been frequently observed in the intestines of wild dead giant pandas since 1995 [28] and the first record, attributed to a species of Ancylostoma, was reported by Zhang et al. in 2005 [41]. However, detailed morphological descriptions, determination of taxonomic status and indicators of pathogenicity of the Ancylostoma sp. derived from giant panda are lacking. The recent collection of parasites from a wild giant panda that died in the Fengtongzai Natural Reserve in Sichuan Province of China resulted in the recovery of fresh Ancylostoma specimens and provided an opportunity to fill some of these gaps in our knowledge. We have used DNA sequence and morphological analysis, applying clear species criteria established in a phylogenetic context [42], to recognize and describe a previously unknown hookworm species from the giant panda. A putative sisterspecies relationship with the 'anthropozoonotic' A. ceylanicum suggests a possible zoonotic risk for transmission and infection to humans. Methods Parasite collection and microscopic examination In November 2013, a wild female giant panda was found dead in the Fengtongzai Natural Nature Reserve, Sichuan Provence of China (Fig. 1). After a routine necropsy, seventeen hookworm specimens (seven males and ten females) were collected from the small intestine under the Scientific Procedures Premises License for the College of Veterinary Medicine, Sichuan Agricultural University (Sichuan, China). In addition, parasite eggs were isolated from the intestinal content by the centrifuge-flotation method using saturated MgSO4 [43]. After washing in physiological saline, the hookworm specimens were either directly fixed in Berland's fluid (95% glacial acetic acid and 5% formaldehyde) for morphological analysis or stored in 70% ethanol for subsequent molecular profiling. For morphology, the hookworms were identified to the genus level on the basis of the existing taxonomic keys and descriptions of Ancylostoma spp. (e.g. [44]). In brief, the worms (n = 15; 6 males and 9 females) were prepared as temporary whole mounts in glycerin after clearing in lactophenol and examined under both dissecting and light microscopy at magnifications of 10–40× and 40–200×, respectively; male and female specimens were characterized morphologically including photo-micrographic imaging and morphometrics. Measurements are given in micrometres (μm) unless specified otherwise and presented with the range followed by the mean within parentheses. In addition, some key characteristics of the adults were drawn with the aid of serial photographs for morphological comparison and differentiation from other related species. These specimens including the type-series and vouchers for molecular analyses have been deposited in the Department of Parasitology, Sichuan Agricultural University (accession numbers code GYY-XY). Molecular profiles and phylogeny For molecular analysis, two adult specimens of Ancylostoma sp. (one female and one male; sample codes FTZ1 and FTZ2, respectively) preserved in 70% ethanol were air-dried and their mid-body regions (~1 cm) were excised individually for extraction of genomic DNA using the Universal Genomic DNA Extraction Kit (TaKaRa, Dalian, China) according to the manufacturer's protocol. The cephalic and caudal extremities of each specimen were retained as archived vouchers. The DNA extract was used as template for PCR amplifications at the nuclear internal transcribed spacer ITS1-5.8S-ITS2 region (734 bp) and mitochondrial cytochrome c oxidase subunit 1 (cox1) locus (393 bp) using primer pairs designed based on the alignments of the relatively conserved regions of the congeneric species A. ceylanicum, A. caninum, and A. duodenale in GenBank. Two PCR primer sets were as follows: ITS15.8S-ITS2, forward: 5′-GTC GAA GCC TTA TGG TTC CT-3′ and reverse: 5′-TAA CAG AAA CAC CGT TGT CAT ACT A-3′; cox1, forward: 5′-ATT TTA ATT TTG CCT GCT TTT G-3′ and reverse: 5′-ACT AAC AAC ATA ATA GGT ATC ATG TAA-3′. The PCR reactions contained ~20 ng of genomic DNA were performed in 50-μl reaction volumes containing 25 μl 2× Phusion High-Fidelity PCR Master Mix (Finnzymes OY, Espoo, Finland), 3 μl gDNA, 3 μL of each primer and 16 μl of ddH2O. PCR cycling conditions carried out in a Mastercycler Gradient 5331 thermocycler (Eppendorf, Germany) were an initial denaturation at 95 °C for 5 min; then for ITS1- 5.8S-ITS2, 35 cycles of 95 °C for 30 s, 39.8 °C for 30 s, and 72 °C for 45 s; but for cox1, 35 cycles at 95 °C for 30 s, 44.1 °C for 30 s, and 72 °C for 30 s; followed by a final step at 72 °C for 10 min. For each amplification, samples without parasite gDNA and host DNA as negative controls were also included. All PCR products were examined on agarose (1%) gels to verify that they represented the target bands. The corrected gel-isolated amplicons were column-purified and sequenced in both directions using terminator-based cycle sequencing with BigDye chemistry (Applied Biosystems, Foster City, CA, USA) on an ABI 3730 DNA sequencer (Applied Biosystems) in TaKaRa Biotechnology Co. Ltd. (Dalian, China). To ensure maximum accuracy, each amplicon was sequenced three times independently. The consensus sequences were utilized for the following bioinformatic analyses and added to GenBank under the accession numbers KP842923 (FTZ1) and KP842924 (FTZ2) for ITS1-5.8S-ITS2 and KP842921 (FTZ1) and KP842922 (FTZ2) for cox1. Sequences of ITS1-5.8S-ITS2 and cox1 of Ancylostoma sp. in the present study were separately aligned with reference sequences from closely related species (Table 1), including the congeneric species A. ceylanicum, A. caninum, A. duodenale, A. braziliense and A. tubaeforme as well as other hookworm species Necator americanus (Stiles, 1902), Uncinaria hamiltoni Baylis, 1933 [45], U. lucasi Stiles & Hassall, 1901, U. stenocephala (Railliet, 1884), U. sanguinis Marcus, Higgins, Slapeta & Gray, 2014 [46], Uncinaria sp., and Bunostomum phlebotomum (Railliet, 1900), using the Clustal X 1.83 program [47]. During the procedure, the nucleotide alignment of cox1 was further adjusted by a codon-guided protein alignment. Given the presence of the ambiguous regions within these alignments, an online version of GBlocks (http://molevol.cmima.csic.es/castresana/Gblocks_server. html) was also introduced here. After refining the alignments using Gblocks, the sequence datasets were used for phylogenetic analyses using both maximum parsimony (MP) (PAUP* 4.10b [48]) and Bayesian inference (BI) methods (MrBayes 3.2 [49]). In the MP analysis, heuristic searches were executed by branch-swapping utilizing tree-bisection-reconnection (TBR) algorithm and 1,000 random-addition sequence replicates with 10 trees held at each step, and finally the optimal topology with bootstrapping frequencies (BF) was obtained using Kishino-Hasegawa, as described previously [50]. For the BI analysis, the nucleotide substitution model GTR + I + G was determined using the Bayesian Information Criteria (BIC) test in jModeltest v. 2.1.6 [51], and the trees were constructed employing the Markov chain Monte Carlo (MCMC) method (chains = 4) over 100,000 (cox1) or 1,000,000 (ITS15.8S-ITS2) generations with every 100th (cox1) or 1000th (ITS1-5.8S-ITS2) tree being saved; when the average standard deviation of the split frequencies reduced to less than 0.01, 25% of the first saved trees were discarded as "burn-in" and the consensus (50% majority rule) trees were inferred from all remaining trees and further plotted in TreeviewX (http://taxonomy.zoology.gla.ac.uk/rod/treeview.html), with nodal supports expressed as posterior probabilities (PP). The livestock hookworm B. phlebotomum was used as outgroup reference and included in each phylogenetic analysis. Paralleled to the phylogenies, among the genus Ancylostoma the new hookworm species coupled with A. ceylanicum, A. caninum, A. duodenale and A. tubaeforme was also subjected to detection of synonymous and nonsynonymous mutations in the mitochondrial cox1 gene using their corresponding protein sequences, followed by determination of genetic distances between them using a distance matrix based on the maximum composite likelihood model in MEGA [52]. Results Family Ancylostomatidae Looss, 1905 Genus Ancylostoma (Dubini, 1843) Ancylostoma ailuropodae Yang, Hoberg & Xie n. sp. Type-host: Giant panda Ailuropoda melanoleuca (David) (Mammalia: Carnivora: Ursidae). Type-locality: Fengtongzai Natural Reserve (30°42′12″ N, 102°56′14″E), Baoxing, Sichuan Province, China. Type-material: Holotype, adult male (GYY-XY 1301); allotype, adult female (GYY-XY 1308); paratypes, three adult males (GYY-XY 1302-4) and three females (GYY-XY 130911). All materials, together with nine vouchers (three males, GYY-XY1305-7; six females, GYY-XY13012-17) containing one male and one female represented by cephalic and caudal extremities, with the mid-body sub-sampled for DNA sequence analysis, are deposited at the Department of Parasitology in Sichuan Agricultural University, Sichuan, China. Collectors: GY Yang, TF Zhang and Y Xie. Site in host: Small intestine (most in the duodenum). Representative DNA sequences: Representative nuclear ribosomal and mitochondrial DNA sequences were deposited in the GenBank database under the accession numbers KP842923– KP842924 (ITS1-5.8S-ITS2) and KP842921–KP842922 (cox1). ZooBank registration: To comply with the regulations set out in article 8.5 of the amended 2012 version of the International Code of Zoological Nomenclature (ICZN) [53], details of the new species have been submitted to ZooBank. The Life Science Identifier (LSID) of the article is urn:lsid:zoobank.org:pub:A2492E99-AA70-4A58- AB70-7FED78E726A3. The LSID for the new name Ancylostoma ailuropodae n. sp. is urn:lsid:zoobank.org:act:2C6B6C1E-5F70-49B7-A303-B4D5AE9C7847. Etymology: The new species is named for the type-host. Description General. Slender, relatively small nematodes of white coloration in life (Fig. 2a). Body cylindrical, tapering toward cephalic and caudal extremities with fine transversely striated cuticle; head oriented dorsally in males and females. Buccal capsule widening posteriorly to prominent oral aperture, possessing two pairs of ventrolateral teeth and two pairs of triangular dorsolateral teeth (Fig. 2b-f ). Ventrolateral teeth vary in size and shape, with small, subaduncate inner and large triangular outer teeth extending dorsally. Dorsal gland well developed, associated with rodlike oesophagus, slightly swollen posteriorly, terminating in a lobed valve at junction with intestine (Fig. 4a, b). Nerve-ring at midlevel of oesophagus. Cervical papillae well developed, conical, situated posterior to level of nerve-ring. Excretory pore opens at level between cervical papillae and nerve-ring (Fig. 5a1, 2). Male. [Based on the holotype and three males.] Body length 8.60–12.00 (10.30) mm, maximum width at midbody 500–520 (510). Buccal capsule 180–220 (200) long, 120–160 (140) wide in dorsoventral view; oesophagus 960–1,500 (1,230) long, 150–190 (170) wide; oesophageal length 12% of total body. Cervical papillae 600–750 (680), excretory pore 500– 580 (530), nerve-ring 390–520 (425) posterior to cephalic extremity. Copulatory bursa well developed, broader than long; dorsal lobe small with lateral lobes projecting in direction of lateral trunks (Figs. 3a-f, 5a5). Dorsal ray thick, 280–390 (350) in length, 40–60 (52) in maximum width; bifurcating at 270–295 (280) from anterior into 2 branches; each branch further dividing into 2 sub-branches; externodorsal rays arcuate, arising from dorsal ray at same level (Figs. 3e-f, 5a5). Lateral rays slender, tapering, and arcuate with a common stem. Anterolateral ray bending anteriad, with medio- and posterolateral rays projecting in parallel, extending to edge of bursa (Figs. 3a-b, 5a5). Antero- and posteroventral rays merge at base and then divide, continuing parallel deep into cleft (Figs. 3c-d, 5a5). Spicules tawny colored, paired, equal, filiform, 2,000–2,900 (2,450) long (Figs. 4e-f, 5a5). Gubernaculum fusiform, 80–120 (90) long, 12–20 (16) wide (Figs. 4c, 5a5). Cloacal papillae (n = 7) (Figs. 4d, 5a5): 1 pair disposed dorsally, 1 pair laterally, 3 single papillae ventrally. Female. [Based on the allotype and three females.] Body 9.80–16.00 (12.90) mm long, with maximum width at mid-body 560–740 (650); width at anus 270–340 (285). Buccal capsule 170–250 (210) long, 130–190 (160) wide in dorsoventral view; oesophagus 1,280–1,320 (1,300) long, 170–250 (200) in maximum width near base. Cervical papillae 800–1,230 (900), excretory pore 760–950 (820), nerve-ring 600–650 (620) posterior to cephali extremity. Vulva opens ventrally in posterior third of body, at 2,450–4,686 (3,480) from caudal extremity; vagina relatively short. Female reproductive system amphidelphic, with poorly differentiated vestibule, paired sphincters and infundibula confluent with uterine and ovarian stems (Fig. 5a3). Tail 90–370 (230) long, terminating in acute, spine-like point 9–25 (17) in length (Figs. 4g, 5a4). Eggs oval, 54–71 × 28–38 (62 × 33) (n = 20) (Fig. 5a6).


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I've categorised them into Carp, Chub, Tench and other. When I got back into fishing the attraction of the 'Commercial Lake' naturally resulted in a lot of carp being caught, However, more recently I've returned to my roots by concentrating more on river fishing, in particular stalking chub.
Most of the photos were taken using a mini-tripod and the self-timer on the camera, so please excuse some of the strange facial expressions!
Each image shows the place and date of capture. By checking the relevant entry in the diary you will find more details. You can filter the diary by using the relevant location link, selecting the archive for the year concerned or using the species tags.
Click on the image to start a slide show.
19lbs 0oz - Fields End - 9 June 2008
18lbs 8oz - Fields End - 18 April 2009
18lbs 3oz - Block Fen - 27 May 2010
18lbs 2oz - Fields End - 20 March 2009
17lbs 0oz - Block Fen - 17 August 2009
17lbs 0oz - Fields End - 23 May 2008
16lbs 0oz - Block Fen - 29 September 2009
15lbs 6oz - Fields End - 22 October 2010
15lbs 6oz - Fields End - 22 October 2010
15lbs 2oz - Block Fen - 11 May 2010
16lbs 9oz - Fields End - 08 August 2019
When I was a lad, carp were fish you read about but didn't expect to catch. The likes of Dick Walker and Fred J Taylor were the carp anglers that we read about in the Angling Times.
When I returned to fishing a few years ago everything had changed. Carp were now the species of choice for many anglers, commercial lakes providing the opportunities to catch these once mythical fish.
3lbs 14oz - Fields End - 22 April 2010
3lbs 14oz - Fields End - 10 May 2010
3lbs 12oz - Fields End - 27 April 2010
3lbs 12oz - Fields End - 17 June 2008
3lbs 10oz - Fields End - 6 July 2010
3lbs 10oz - Fields End - 11 February 2011
3lbs 10oz - Market Drayton private lake - 27 June 2003
Most of the tench featured here were caught at Fields End lake where it's fair to say the primary quarry was carp. It's surprising that some were caught in winter, and one actually took floating bread crust.
The first picture shows the best tench I caught while fishing a private lake that belonged to the owners of a cottage where we stayed on holiday in 2003.It was a shallow heavily silted water and the tench there also came to the surface.
5lbs 2oz - River Welland - 23 June 2014
4lbs 8oz - River Welland - 23 July 2009
4lbs 8oz - River Welland - 14 March 2011
4lbs 8oz - River Welland - 12 July 2011
4lbs 8oz - River Welland - 13 November 2012
4lbs 7oz - River Welland - 5 July 2011
4lbs 7oz - River Welland - 27 June 2013
4lbs 7oz - River Welland - 10 March 2014
4lbs 5oz - River Welland - 16 June 2015
4lbs 4oz - River Welland - 14 March 2011
When I was young most of my fishing was in rivers, principally the Thames. There were no such things as the modern commercial lakes, and the natural lakes tended to be private.
After a few years fishing my local commercial lake I started to get a hankering to return to river fishing. I prefer smaller rivers with varying characteristics and like stalking chub. This requires me to travel light. No wheel barrows full of carping paraphernalia!
Barbel 7lbs 1oz - Fields End - 15 June 2018
Barbel 5lbs 3oz - Fields End - 21 March 2011
Barbel 5lbs 0oz - Fields End - 7 April 2011
Crucian carp 2lbs 7oz - Fields End - 1 April 2011
Crucian carp 2lbs 2oz - Fields End - 27 April 2010
Carp 10lbs - Docklow Pools - 9 September 2010
Carp - Rivere Indrois (France) - 23 June 2012
Roach 1lb 7oz - Fields End - 27 April 2010
Roach 1lb 5oz - Fields End - 31 January 2011
Chub 3lbs 8oz - River Wye - 2 September 2010
A collection of other fish included not for their size but because they represent a bit of variety in terms of species and locations.
For example I've included a common carp caught from a river when in holiday in France, a River Wye chub, again when on holiday, and my biggest carp from Docklow Pools where we stayed for a week in 2010.

subset: commoncrawl


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Arts & Crafts in Psychiatric Occupational Therapy
The profession of occupational therapy (OT) has many of its roots in the Arts and Crafts Movement, a response to the industrialized production at the end of the nineteenth century which promoted a return to handcrafting (Hussey, Sabonis-Chafee, & O'Brien, 2007). Its origins also were strongly influenced by the earlier Moral Treatment Movement, which sought to improve the treatment of the institutionalized mentally ill population (Hussey et al., 2007).
Therefore, the use of art and crafts in psychiatric settings has played a significant role in OT from the beginning. Furthermore, a core idea in the development of OT is that "occupation, or doing with the hands, can be seen as an integral part of experiencing a meaningful life" (Harris, 2008, p. 133).
Crafts have many potential therapeutic applications: motor control, sensory and perceptual stimulation, cognitive challenges, and enhanced self-esteem and sense of efficacy (Drake, 1999; Harris, 2008).
Crafts, too, are also often used to assess cognitive functioning: "Crafts were selected because they can be standardized to present new information that is meaningful to the disabled most of the time" (Allen, Reyner, Earhart, 2008 p. 3).
However, in recent OT literature the term "craft" appears to have acquired less worthy connotations. In addition, the emergence of art therapy as a psychoanalytic tool, as well as the use of arts and crafts in recreational therapy, questions the role of the arts in current OT practice with psychiatric patients.
In a study assessing the perspective of inpatient psychiatric clients on occupational therapy, it was found that arts and crafts were the most popular of sixteen activity groups offered. However, only a third of the participants in the arts and crafts group indicated that they found the activity to be helpful and beneficial (Lim, Morris, & Craik, 2007).
An earlier study revealed only a slightly higher than neutral rating of craft groups among psychiatric patients randomly assigned to various activities (Kremer, Nelson, & Duncombe, 1984).
In the course of my investigation of the use of art in occupational therapy in inpatient psychiatric settings, a recurring complaint in several articles was the lack of research on both subtopics: the current role of arts and crafts in OT, and the current role of OT with psychiatric patients.
Although the studies quoted offer only moderate support to the hypothesis that arts and crafts are beneficial to psychiatric patients, they are only two studies. Furthermore, rather than refute the use of arts and crafts altogether, they reinforce the doctrine common to occupational therapy that any treatment must be specifically tailored to fit the interests and needs of the client.
Allen, C. K., Reyner, A. & Earhart, C. A. (ed) (2008). How to Start Using the Allen Diagnostic Module: A Guide to Introducing Allen's Theories Into Your Practice (9th ed.). Colchester, CT: S&S Worldwide.
Drake, M. (1999). Crafts in Therapy and Rehabilitation (2nd ed.). Thorofare, NJ: Slack Incorporated.
Harris, E. (2008). The meanings of craft to an occupational therapist. Australian Occupational Therapy Journal (55), 133-142.
Hussey, S. M., Sabonis-Chafee, B., & O'Brien, J. C. (2007). Introduction to Occupational Therapy (3rd ed.). St. Louis, MO: Mosby.
Kremer, E. R. H., Nelson, D. L., & Duncombe, L. W. (1984). Effects of selected activities on affective meaning in psychiatric patients. The American Journal of Occupational Therapy, 38(8), 522-528.
Lim, K. H., Morris, J., & Craik, C. (2007). Inpatients' perspectives of occupational therapy in acute mental health. Australian Occupational Therapy Journal (54), 22–32.
Song, W. (2018). Arts & Crafts in Psychiatric Occupational Therapy. Psych Central. Retrieved on October 28, 2020, from https://psychcentral.com/blog/arts-crafts-in-psychiatric-occupational-therapy/
Last reviewed: By a member of our scientific advisory board on 8 Jul 2018
Published on Psych Central.com. All rights reserved.


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Your First Child and 5 Ways of Financial Planning
PNB MetLife 19-05-2016 10:50:48 AM
From researching car seats and cribs to decorating a nursery, there's a lot to do when you are expecting a new baby. In addition to readying your physical house for your bundle of joy, you will also want to be sure your financial planning is in order.
There hardly is a more important time to start thinking about your finances. While it may seem overwhelming to add yet another item to your to-do list, some smart financial planning now will ensure you are prepared for the changes that come with having a child. Discover five financial tasks prospective parents should prioritise before their newest family member arrives. That way you can focus on child development and quality time. Read More
- Create or review your budget
You may have been living easily on one or two incomes without a child, but having a baby brings additional expenses - not to mention potential changes to your income. "When you're in the midst of it and you're trying to make ends meet and you probably haven't slept a lot - that's the worst time to start thinking about your budget.
For expectant parents, the first step is simply getting a clear picture of how much you earn, how much you spend and how much you save. That way you'll be able to make informed decisions about how much leave you can take, how much you can spend on child care and whether you can afford to reduce your work schedule going forward. Online budget tools can help you set up a monthly budget and track your expenses.
- Prepare for your parental leave
For most parents, quality child care for your newborn comes with a cost. You want to think about whether you or your partner - or both - are going to take time off work, and how that's going to impact your income.
Investigate whether your employer offers paid parental leave. If you plan to take unpaid leave, examine your budget to see how long you can last on an abbreviated income and then start saving for those paycheck-free weeks or months ahead.
- Contemplate quality child care costs
If you anticipate needing quality child care, you will want to explore your options. The cost of care varies by region and type of care (a day-care centre versus a nanny or in-home help. Assess what you can spend, investigate what's available in your area and consider creative ways to save. For example, sharing a babysitter with one or two other families or asking someone who is already retired in your family can greatly reduce the expense and, as an added bonus, gives your baby some instant buddies.
- Purchase life insurance
It may seem odd, especially if you are still young, but now is the time to start thinking about life insurance. Should something happen to you or your partner, life insurance can prevent further financial ruin and provide for your child's immediate and future needs. How much life insurance your family needs, depends on a variety of factors including your current income and housing costs.
- Create a will
Most people think of wills as a way to distribute your assets. But even more importantly, your will designates who has guardianship of your child in the event you and your partner pass away. Creating a will doesn't need to be complicated. You can even use an inexpensive online service or store-bought documents to name a guardian. But doing so is imperative: If you don't choose someone, the court will choose a guardian for your child - and it may not reflect your wishes.
For expectant parents, the months before the baby arrives can feel like a whirlwind of activity. But taking the time to financially prepare for your little one can provide peace of mind during this busy time, and allow you to focus on your family and child development after your baby's arrival.
To know more about Term Insurance browse the website for various Term Plans offered by PNB MetLife
The aforesaid article presents the view or an independent writer who is an expert on financial and insurance matters. PNB MetLife India Insurance Co. Ltd. doesn't influence or support views of the writer of the article in any way. The article is informative in nature and PNB MetLife and/ or the writer of the article shall not be responsible for any direct/ indirect loss or liability incurred by the reader for taking any decisions based on the contents and information given in article. Please consult your financial advisor/ insurance advisor/ before making any decision.
PNB MetLife India Insurance Company Limited, Registered office address: Unit No. 701, 702 & 703, 7th Floor, West Wing, Raheja Towers, 26/27 M G Road, Bangalore -560001, Karnataka.
IRDAI Registration Number 117. CI No: U66010KA2001PLC028883. For more details on risk factors, terms and conditions, please read the sales brochure carefully before concluding the sale.
The marks "PNB" and "MetLife" are registered trademarks of Punjab National Bank and Metropolitan Life Insurance Company, respectively. PNB MetLife India Insurance Company Limited is a licensed user of these marks.
Call us Toll-free at 1-800-425-6969. Phone: 080-66006969, Website: www.pnbmetlife.com, Email: firstname.lastname@example.com or Write to us: 1st Floor, Techniplex -1, Techniplex Complex, Off Veer Savarkar Flyover, Goregaon (West), Mumbai – 400062, Maharashtra. Phone: +91-22-41790000, Fax: +91-22-41790203
• IRDAI is not involved in activities like selling policies, announcing bonus or investment of premiums. Public receiving such phone calls are requested to lodge a police complaint.


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can anybudy sell gpl script?
i read the second para of gpl license's Preamble
is that mean we can sell gpl scripts but it will be always given with full rightsWhen we speak of free software, we are referring to freedom, not price. Our General Public Licenses are designed to make sure that you have the freedom to distribute copies of free software (and charge for this service if you wish), that you receive source code or can get it if you want it, that you can change the software or use pieces of it in new free programs; and that you know you can do these things.
am i right?


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Bill joins the SBDC with over 29 years of experience in Retail and Commercial Banking. He has worked for both community and nationwide banks and specializes in agriculture and commercial business credit analysis and structuring.
Prior to his work at the SBDC, Bill has taught Banking and Economic classes at Blue Ridge Community College. He has also been involved in business development in the Shenandoah Valley and active in various community organizations. He is a past Treasurer of the Salvation Army and the current Treasurer of the Rockingham County Fair Association. Bill is also currently a member of Bridgewater Retirement Community's Foundation Board of Directors.
Raised in the Shenandoah Valley, Bill is a graduate of the Virginia School of Bank Management where he was Vice President of his graduating class. Bill earned his BS in Agricultural Economics from Virginia Tech and his MBA from Eastern Mennonite University.


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Kim Jin-tae (Hangul: 김진태; born December 19, 1980), better known by his stage name Verbal Jint (Hangul: 버벌진트), is a South Korean musician, rapper and record producer who is known for his groundbreaking innovations in Korean hip hop rhyme schemes. He established himself as one of South Korea's most popular underground rappers of the 2000s before achieving mainstream success. He is signed to the hip hop record label Brand New Music, under which he runs his own independent label, Otherside.
Before Verbal Jint's official debut in 2001, Korean hip hop lacked a fundamental component of rap, the rhyming. Verbal Jint later said in an interview with the Korea Times, "People who came before us didn't have much interest in rhyming; artists before us were satisfied with talking fast and thinking that it was rapping — and that sold then." Verbal Jint's debut mini-album, Modern Rhymes, introduced new innovations in achieving the grammatical accuracy needed to arrange Korean successfully into rhymes. He was the first to create actual rhyme schemes in Korean and his method is now the standard for Korean rapping within the hip hop scene. The rhyme work and flow of his music have been considered revolutionary within the Korean music industry as they have rapidly changed the construction of Korean hip hop music and thus its style and lyrical qualities.
Verbal Jint was born in Seoul, South Korea. He attended Hanyoung Foreign Language High School, earned an economics degree from Seoul National University, and is currently taking time off from pursuing a law degree at the Hanyang University School of Law.
Verbal Jint completed his mandatory military service for South Korea in the KATUSA program, where Korean soldiers who demonstrate a high level of English fluency and aptitude serve alongside United States Army forces in South Korea.
Verbal Jint began his rap career as a member of the Korean hip hop crew "Show N Prove" (SNP) and released his first solo songs in 1999, including, "Big Brag," "How High School," and "Foul." He released his first mini-album, Modern Rhymes, in 2001. The album is credited with introducing rhyme schemes into Korean rapping.
It was several years until Verbal Jint's next releases, 2007's Favorite and 무명. The following year, he formed the hip hop crew Overclass with rappers Warmman and Lobotomy, among others. Notable rappers and singers including San E, Swings, and Urban Zakapa would later join the crew.
Verbal Jint experienced his first mainstream success in 2009, when his 2008 album, Framed, won Best Hip Hop Album at the Korean Music Awards. In 2010, he began releasing music under Brand New Stardom, a record label owned by rappers Cho PD and Rhymer. When the company split in two in 2011, Verbal Jint followed Rhymer to his new label Brand New Music.
In 2011, Verbal Jint collaborated with Swings, San-E, L.E.O., Baby Bu, Dawn, and designer Brownbreath on the song, "Stand Up, Japan!," with all proceeds from the digital single donated to help relief efforts after the Japanese Tohoku tsunami.
Later that year, he released the album Go Easy, and its single, "You Look Good," ultimately reached #5 on the Gaon Digital Chart. He promoted the single in October on music program You Hee Yeol's Sketchbook, where he also discussed his side-career as a voice actor in commercials. He also performed the song in Japan as a guest at actor and singer Jang Keun-suk's Tokyo Dome concert on November 26.
Verbal Jint held his first solo concert, "You Look Happier," in December 2011. The same month, he made his first appearance on the music show M! Countdown.
In June 2012, Verbal Jint appeared in the first season of Mnet's hip hop reality program "Show Me the Money." His team, composed of himself and rookie rapper Go Young Bin, was eliminated in the second round after a performing a hip hop version of miss A's "Breathe."
That same month, he released the album, 10 Years of Misinterpretation. The album singles, "Good Morning," and "Pretty Enough" were hits, reaching #5 and #6, respectively, on the Gaon Digital Chart. He performed "Good Morning" in a special collaboration with the band 10cm in July at the two-day Green Groove Festival in Boryeong, alongside After School, Son Dambi, Wonder Girls and Akon.
Verbal Jint participated in several successful collaborations in 2013, including the hit singles "If It Ain't Love" featuring Ailee, "Hello" by legendary singer Cho Yong-pil, "Take Care of Christmas" with Shin Seung Hun, and a cover of Deux's "Only For You" with Bumkey. He also collaborated live with girl group Girl's Day at the Mnet 20's Choice Awards in July, and with Bumkey and San E at the SBS Gayo Daejun awards in December. That year, he fulfilled his long-time wish to collaborate with Hyolyn of SISTAR when she surprised him with an unscheduled appearance on You Hee Yeol's Sketchbook and subsequently featured in his performance of "You Look Good."
In May 2014, Verbal Jint went on a world tour with Bumkey, Beenzino, Kanto, and Hwayoung, holding concerts in New York City, Seattle, Los Angeles, and Sydney. He had planned to release a new album, entitled GO HARD Pt. 1: The OTHER SIDE prior to the tour, but he postponed the album's release indefinitely due to the Sewol Ferry Disaster. Later that year, a music video he featured in was delayed due to another disaster. He was featured along with Beenzino, Bobby, B.I. and Mino in Epik High's single "Born Hater" off their eighth studio album Shoebox. The music video was scheduled for pre-release on October 17, but was delayed one day to pay respect to the victims of the Pangyo Techno Valley Vent Collapse. The song received a 19+ rating for profanity and deemed inappropriate for broadcasting by KBS on their media channels. However, the song was a success and reached #3 on the Gaon Digital Chart.
Later that year, Verbal Jint featured on "Rainstorm by Rainstone," a collaborative track with producer Rainstone, American R&B singer Brian McKnight, and San E.
In 2015, Verbal Jint made his first appearance on the TV variety show Running Man in a "hip hop star special" with Jay Park, Jessi, and other rappers. He continued his variety show appearances that summer as a judge on the 4th season of Mnet's hip hop reality program Show Me the Money, where he represented record label Brand New Music alongside San E. He featured on charted singles from show contestants Black Nut and Basick, the latter of whom won the season as part of "Team Brand New Music." After the show's finale, Verbal Jint performed with the judges and contestants from the season in a world tour in South Korea and the United States. Later that year, he appeared on seasons one and two of Show Me the Money spin-off Unpretty Rapstar, during which he produced several singles for contestants.
Verbal Jint released two albums in 2015. On August 31, he released the mini-album Yeoja with Sanchez of the hip-hop trio Phantom. And, after three years of preparation, he released the album GO HARD Pt. 1: The OTHER SIDE on December 19. He also featured on several singles, including Girls' Generation's Taeyeon's solo debut's title track "I," which ranked number one across eight different real time music charts shortly after its release on October 7.
In November 2015, Brand New Music representatives announced that Verbal Jint plans to start an independent label while continuing to promote under Brand New Music.
In addition to his career as a rapper, Verbal Jint has provided voiceovers and narration for many TV shows and advertisements. His voice has appeared in South Korean TV commercials for brands including Vitamin Water, LG, and Hyundai.
Source: wikipedia


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La Liga Preview: Getafe vs. Córdoba
Match Date: 03 October 2014 (local time)
Venue: Coliseum Alfonso Pérez
After losing one of its key players due to injury, Getafe is in dire need of making big adjustments in its techniques and strategies. Fortunately, the sports betting favorite seems to have the odds in its favor. Pitted against the newly-promoted Cordoba, it does not take a genius to see that Getafe, indeed, has the advantage over its opponent.
The contenders
A broken clavicle will sideline Getafe's striker, Alvaro Vazquez and he is expected to stay out of the pitch for approximately three (3) months.
Vazquez' absence created a major impact in the club's scoring, which is crucial in its attempt to retain its La Liga status. Just recently, Getafe showed that it is back to its winning ways when it clinched its 2nd victory after experiencing 3 consecutive losses. But with Vazquez injury, Getafe's plans will experience a major turn.
Nevertheless, they can use the match against Cordoba to score more points and hopefully, create a buffer zone that will prevent them from slipping into the relegation zone.
Winless and sitting at the rock bottom pit of the table, Cordoba's head honcho, Albert Ferrer stressed that a draw is still better than losing all 3 points. This was after his side forced a scoreless stalemate against Espanyol.
Ferrer has readily proven his point. But on the contrary, Cordoba's current situation cannot rely on draws. What they need is a win or they might see themselves returning to Segunda Division.
Possible head turners
Cordoba's Luso is one of the head turners that Getafe should watch out for. The prolific midfielder is readily capable of causing an upset that may halter Getafe's campaign this season.
Getafe 2-0 Córdoba
Image Source: Vavel


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The Film and Digital Media Department is proud to announce the recipients of the 2019 Deans' and Chancellor's Awards.
These awards recognize exceptional achievements in research projects or other creative activities, in order to both encourage outstanding scholarship and promote research as an important part of undergraduate information. The following students, whose creative and scholarly excellence is being recognized with the 2019 Deans' and Chancellor's Undergraduate Awards, will receive a cash award and certificate during Student Achievement Week (June 4-7, 2019.
Jelica Hipolito, Sabrina Ilumin, Maybelle Alvarez and Angie Molina "Anak, how are you? (My child, how are you?) (Short Film)
Faculty sponsor: Susana Ruiz
Nicholette Lindsay "John Hughes, Teenagers, and the Corporate American Dream" (Thesis)
Faculty sponsor: Shelley Stamp
Leah Fuenes, Sam Gouldthorpe, Leslie Carrillo-Lorenzo, Ariel Baruch, Cameron Mccrea and Megan Meelley "Sister of Mine" (Short Film)
Faculty sponsor: Larry Andrews
Rachel Abrahams "The Duality of the Face in Cinema: From Ubiquity to Obscurity" (Thesis)
Faculty sponsor: Jenny Horne
We are very proud of these students and extremely pleased that their outstanding scholarly and creative work has been publicly honored this year.


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|Technology Name
|Lead Researcher
Our innovation: Neuropathic pain- One of our distinctive results which we optimized recently identifies several compounds that we identified as having a potential protective role in neuropathic pain. We pursued this finding in collaboration with ...More
|Tabach Yuval
Category Life Sciences and Biotechnology Keywords Ultra low dose radiation CT scanning, repeat CT scanning Current development stage For medical device: TRL3 - Hypothesis testing and initial POC is demonstrated in limited number of ...More
|Joskowicz Leo
Super Active Leptin Antagonists for Treatment of Autoimmune Diseases and CKD-associated Cachexia (No. 198)
Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...More
|Gertler Arieh
Categories Oncology, Cancer, Diagnostics Development Stage In vitro proof of concept and small animals Patent Status PCT application filed Market Cancer testing is currently one of the most important growth opportunities diagnostics ...More
|Karni Rotem
Background Most cancers are unstable and highly susceptible to cell death; hence tumors represent a steady-state picture of unregulated proliferation as well as ongoing cell death. Therefore, substantial levels of tumor specific DNA may be ...More
|Hellman Asaf
Targeting and Imaging of Long-non-coding-Oncogenic-RNA by In-situ Imaging of micro-metastases (No. 3177)
Background Fluorescence guided surgery is currently clinically approved for non-specific fluorescent molecules (ICG and MB) and is therefore limited in terms of sensitivity and specificity. Most cancer targeted fluorescent molecules in ...More
|Yavin Eylon
Background Very small tumors (<5mm) in gastrointestinal GI tract can hardly be detected by external means (CT, MRI, etc.) or ultrasound endoscopic examination. Stomach and liver cancers as well as pancreas are deadliest diseases ...More
|Feldman Yuri
Background X-ray computed tomography (CT) instruments are among the most available, efficient and cost-effective imaging modalities in hospitals. The field of CT molecular imaging agents is emerging relying mainly on detection of gold and ...More
|Blum Galia
Decoy-Oligonucleotides Inhibiting RNA-Binding Proteins for Treatment of Cancer and other Diseases (No. 3107)
Background Currently there are no molecules that can directly inhibit the activity of splicing factors. We created decoy oligonucleotides that directly bind and inhibit the splicing activity of splicing factors without affecting their ...More
|Karni Rotem
Background The process of cancer metastasis consists of a series of sequential events that requires deregulated proliferation and eventually distal dissemination involving detachment from the extracellular matrices and invasion of the ...More
|Breuer Eli
Background It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ...More
|Nechushtai Rachel
Background Existing methods for removing potentially tumorigenic residual pluripotent stem cells (PSCs) from differentiated cultures are based on either genetic manipulations or on cell sorting. Such processes are generally not suitable for ...More
|Benvenisty Nissim
Precise Epigenome Therapy Using DNA Methylation and Demethylation Enzymes Fused to CRISPR/Cas9 (No. 4301)
Background Epigenome editing by DNA methylation or demethylation of regulatory sequences are widely required in medicine and in biomedical research, but current technologies are non-specific and provide unpredictable effects. This technology ...More
|Hellman Asaf
Dr. Sharon Merims, Hadassah Medical Center Background Many of the anti-neoplastic tyrosine kinase inhibitors are associated with prominent and sometimes dose-limiting dermatologic complications. Of severe clinical implication are the specific ...More
|Benny Ofra
Background Glioblastoma multiforme (GBM) is a common, very aggressive brain cancer with a dismal prognosis, affecting young and middle-age adults with no effective treatment. Former efforts to diagnose glioblastoma tumors and tailor personal ...More
|Hellman Asaf
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...More
|Reich Reuven
Background Mutations in specific genes or proteins variability can dramatically enhance our probability to get cancer. Similarly, genetic variability could have the opposite effect and actually protect us from cancer, other diseases and even ...More
|Tabach Yuval
Simple Diagnostic Tool based on Mechanical Properties of Cancer Cells for Malignancy Level Assessment (No. 4381)
Background To date, clinical tests that assess the level of malignancies from patient biopsies rely almost inclusively on histological analysis for specific markers and morphological cues as well as on genetic data i.e mutation analysis. In ...More
|Benny Ofra
New Small Molecules as Inhibitors of the Prolactin Receptor for Treatment of Breast Cancer, Nociceptive Pain and Migraine (No. 4471)
Additional information will be provided upon requestMore
|Domb Abraham
Category Life Sciences and Bio Technology Keywords Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center. Application Cells with multidrug resistance (MDR) due to aberrant ...More
|Barenholz Yechezkel
Our Innovation We found and patented that approved drugs enhance the expression of NKp30 ligand. The upregulation is persistent and does not affect cell viability. We suggest to use this new modality as a combination therapy to improve ...More
|Tirosh Boaz
A new platform of drug-delivery for Cancer Immunotherapy and for other Pathologies with high Cathepsins activity (No. 4395)
Background The release of targeted drugs is often achieved by attaching the drug load to a carrier through specific peptide sequences which are cleaved by proteases that are highly expressed at the desired location. Cathepsins proteases, ...More
|Blum Galia
Background Recent reports claim that about 38% of human breast cancers may contain sequences related to MMTV. Antibodies generated against mouse lymphoma cells that harbor the virus MMTV (mouse mammary tumor virus) were used to recognize ...More
|Hochman Jacob
Once-daily, sustained-release Sirolimus delivery system Categories Oral Cavity, Oncology/Cancer, Sustained Release, Drug Delivery Development Stage Prototypes tested in vitro; pharmokinetic and pharmacodynamic testing in human volunteers ...More
|Friedman Michael
A novel and personalized method for identifying the optimal anti-cancer treatment, through simultaneous detection of unique tumor sensitivities to multiple drugs or drug combinations in a multiplex manner, (this can be done) in vitro on cancer ...More
|Willner Itamar
New Ti(IV) metal complexes of Salan-ligands for Cancer treatment with reduce side effects (No. 2497)
Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...More
|Tshuva Edit
Background Considerable efforts have been invested in recent years in developing new, effective, yet less toxic drugs for targeted cancer therapy. Currently, this diverse group of drugs includes monoclonal antibodies, immunomodulators, ...More
|Galski- Lorberboum Haya
Computational Tool for the Design of Personalized Drug Cocktails, Based on Intra-Tumor Subpopulations (No. 7741)
Cancer research is moving into the frontiers of how to assign the correct drug(s) to a given patient. Cancer clinicians and researchers commonly search for overexpression of oncogenic biomarkers to assign a targeted treatment, but lack ...More
|Kravchenko-Balasha Nataly
Background Neutrophils are potent effector cells in a wide number of infectious, inflammatory and cancerous conditions. Modulation of Neutrophil functions in these conditions may have significant therapeutic benefits and effects on disease ...More
|Granot Zvika
Background Synthetic biology is the discipline of engineering application-driven biological functionalities that were not evolved by nature. Early breakthroughs of cell engineering, which were based on ectopic (over)expression of single sets of ...More
|Nissim Lior
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Article by Ericwilliams
Yoga is really a complete exercise for the mind, body and soul and it may give a person an alteration to understand himself in a new light. Regular practice of Yoga has been recognized to reduce stress, increase concentration as well as benefit one's all around health. Various postures and Asana in Yoga have their roots in ancient Indian traditions that promote the quest for enlightenment through the unification of the physical and also the spiritual.
Today, Yoga has become the way of life for its practitioners who're enhancing the quality of their life by experiencing and enjoying the purity and serenity offered by Yoga. The meditative aspect of Yoga to lose weight has several advantages as it helps a person in maintaining focus, improving breathing, and also maintaining a posture that benefits our body. The exercise of breathing in and out in long breaths detoxifies the body and leaves a person feeling fresh and energized. Yoga is also a great way to boost one's confidence and self confidence as Yoga improves one's creative prowess as one has the capacity to better concentrate on everything in life. Yoga makes one feel a sense of calm and positivist that can't be felt by any other type of exercise. The practitioners of Yoga can transcend the physical boundaries to achieve into the spiritual realm and find their true self.
Yoga benefits could be categorized into physical, psychological and biochemical benefits. This categorization informs us that yoga provides all around health benefits. It's a holistic approach towards your wellness. Moreover, it's a perfect exercise that has benefited people from all of walks of life.
Yoga is an exercise which has been used for over 5000 years. It has contained tons of different theories observations and principles concerning the mind-body connection, which is now being studied by today's science. You will find over 100 different types of schools of yoga. For instance, Heath yoga is currently one of the most widely practiced forms in America . Hatha yoga has a wide selection of movements, body postures, and breathing techniques. In order to increase your hot yoga benefits you need to practice the 3 main aspects of yoga, which are Asana (postures), Pranayama (breathing), and meditation.
Yoga is surely an ancient practice that anyone at every age are capable of doing. There are several that believe we're natural born yogis, remember when the practice of pulling our toes up to our ears was fun so we would laugh about this. Then we all grow up and rather than enjoying our flexibility and balance we commence to carry stress. That stress is carried in our shoulders and our backs and our necks. Basically we lost our balance, our inner and outer balance.
To learn yoga, you don't need any special equipment or clothes. You simply need a yoga mat plus some comfortable clothes. Choosing a nice quiet place is best when you are starting as it can help you focus. Yoga shouldn't be treated just like a complicated set of free hand exercises. Doing so will deprive you of all of the great benefits that yoga can provide you with apart from a healthy lifestyle.
About the Author
It's a great pleasure for me to provide you health articles regarding mens health issues like hair loss treatment,viagra generic, impotence treatment,viagra,swine flu,kamagra 100mg etc. I used to enjoy a lot writing about health issues because it's my area of interest from childhood.


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suggested headsets: oculus rift s & valve index unsuggested headsets: all htc vives (lol) ALSO CHECK OUT THEEES VR GAMES YES: MY NEW EPIC VR GAME (dont need vr to join): https://www.roblox.com/games/4552752990/NEW-VRBLOX MY EVEN NEWER NEW XCLUSIVE VR GAME: https://www.roblox.com/games/4599261145/skeds-vr-development-demo ----------------- if you want to donate to support development (i would really appreciate it) you can here: https://www.roblox.com/catalog/5440967438/small https://www.roblox.com/catalog/5440977452/medium https://www.roblox.com/catalog/5440983846/big JOIN THE VR COMMUNITY GROUP! https://www.roblox.com/groups/5688275/VR-Community ----------------- P.S. IT WOULD BE VERY EPIC 😎 IF YOU SUBBED TO MY YOUTUBE BELOW! THANKS!!! ----------------- big thanks to D3LT40P, fish, cathating89 and AsusAlex for being staff and keeping the place from dying within 10 minutes!! 👍
Private Servers
There are currently no running games.


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I really, REALLY, don't like the start of a new school year (shhh, don't tell my kids!). Not only are you coming off of a carefree summer where the weather is warm and outdoor activities are plentiful, but it also means that your immune system can start taking some hits with cold weather season is just around the corner. Any time there are bunches of kids in a contained area like a classroom, you know it's inevitable that you will need boxes of tissues ready at home!
All that being said, this year I feel so much more prepared for this cold weather season because I have my oils to help support our immune systems! Of course I am constantly reminding my kids to make sure they wash their hands well at school, especially before lunch and after using the bathroom. But in addition to reminding them about good hand washing and of course praying over their health daily, this year I also have Young Living Thieves oil… a blend of Clove, Lemon, Cinnamon Bark, Eucalyptus, and Rosemary.
Thieves® essential oil blend was inspired by the legend of four 15th-century French thieves who formulated a special aromatic combination composed of clove, rosemary, and other botanicals they used while robbing the dead and dying
Every morning before school, we use Thieves oils.
Additionally, I send my daughter to school with a bottle of Thieves Waterless Hand Purifier… I wasn't sure whether she would get a chance to wash hands before lunch, so I wanted to make sure she had some way of cleaning her hands after touching stuff all morning that tons of inevitably sick kids had already touched!
Thankfully she's since told me they DO get a bathroom break before lunch to wash up, so she said she uses the Purifier after lunch. Kind of defeats the purpose, but she said she loves using it! It smells so good. She wanted me to leave it in her bag. :)
Of course nothing is foolproof… to regularly support their immune systems, I keep my Premium Starter kit on hand (which includes Thieves!) plus a few more oils. We've seen positive health benefits!
I'm thankful that we have Thieves oil to help our kids' immune systems in top shape in the classroom! This is one oil I never let run out!


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Los Angeles Rams Tickets
Since 2009, TicketIQ (formerly TiqIQ) has used its intelligence to help fans get the best deals, and now offers a Low Price Guarantee on every event.
Questions about the coronavirus? If your event is canceled we'll fully refund your tickets. Learn More
Since 2009, TicketIQ (formerly TiqIQ) has used its intelligence to help fans get the best deals, and now offers a Low Price Guarantee on every event.
Primary market tickets for Rams home games are available through the Rams website via primary partner Ticketmaster. There are multiple choices of season ticket packages available, which start at $355.
On the secondary market TicketIQ has Low Price Guarantees on Rams tickets for all games on the 2019 schedule, in addition to Low Price Guarantees on all NFL tickets, which means that if you find a secondary market ticket for less on a site like StubHub or SeatGeek, we'll give you 200% of the difference in ticket credit. TicketIQ customers save an average of 5%-20% compared to StubHub and SeatGeek.
The reigning NFC champions are hoping to make it one step further this season after falling to the New England Patriots in Super Bowl LIII. Heading into the upcoming season, it is expected to see Todd Gurley getting fewer touches, so possibly he can be fresher for the postseason
Los Angeles will play seven home games because the Rams will be the "home team" when they play at Wembley Stadium in 2019 against the Cincinnati Bengals. The Rams' ticket prices are the 17th most in the NFL at $223 per ticket. The price is 17% higher than last year's Rams ticket and 48% higher than the average Rams ticket five years ago.
The first 2019 regular season contest at Los Angeles Memorial Coliseum is a rematch of the NFC championship. The Rams were victorious, 26-23, in the game that had one of the most controversial referee no-calls in NFL history. There is no surprise that the asking price for this ticket is the highest of all the Rams' 2019 home games.
When the Rams and Buccaneers last met in 2016, Todd Gurley ran for 85 yards and two touchdowns, as the Rams won, 37-32, and extended their win streak over Tampa Bay to five games. The get-in price is tied for the lowest price for a Rams home game this regular season.
Before sweeping the 49ers last season, the Rams had not had much success over the last decade in meetings with San Francisco. In Week 17 in 2018, the Rams rode Jared Goff's four touchdowns to their NFL-best 13th win of the season.
The Bears have been very successful in recent history against the Rams, as Chicago has won six of the last seven meetings. In 2018, the Bears defense stifled Goff, Gurley and company. Chicago intercepted four of Goff's passes while Jordan Howard and Tarik Cohen combined for 192 total yards.
The Ravens face the Rams for the first time in Los Angeles. The Rams will be looking for their first win over Baltimore since 2003. Gurley will look to improve from his 66-yard, one-touchdown performance in which the Ravens scored 13 unanswered points to win, 16-13, in 2015.
The Rams have had the Seahawks' number recently, as Los Angeles finished 2018 by extending its win streak to three games over Seattle. Both of the contests in 2018 between the Rams and Seahawks were tight games, as the margin of victory was a combined seven points.
The cheapest ticket for a Rams home game this season is currently the season finale against rookie Kyler Murray and the Cardinals. Los Angeles swept the series from Arizona in both 2017 and 2018.
TicketIQ is committed to the cheapest tickets possible, and we make much less on sold out tickets compared to other major marketplaces like StubHub and Vivid. That means ticket buyers save from up to 25% on TicketIQ on sports, music and theater. We're able to do this because we also work with teams, venues, and other ticket owners, to help them sell tickets at face price, directly to consumers like you, through Ticketmaster and Paciolan. For an overview of the 2019 NFL Ticket Buying landscape, and details on the cheapest way to get tickets for every team, visit the TicketIQ Blog.
The LA Coliseum just has one bowl of seating, with 93 rows per section. Rows 1-40 lie in lower tier, rows 41-70 in the middle tier, and rows 71-93 as the upper tier. Sections 6-7 and 22-23 are the closest to midfield. There are 19 sections in total at LA Coliseum.
Lower-level center sections include 120-124 and 104-109. 100-level end sections include 119, 109, 125, 103 with 100-level corner sections of 126, 127, 128, 100, 101 and 102.
200-level center sections are 220-224. 200-level corner sections include 218, 219, 225, 226, 203, 202, 210, 211. 200-level end sections include 201, 200, 202, 211, 212 and 213.
300-level center sections are 320-324. 300-level corner sections include 310-312 and 301-303. 300-level end sections are 326, 327, 302, 301, 318, 319, 311 and 312.
The Club Level can be found amidst 400 sections, ranging from 401-412. Club Level is classified into C401-C412. Fans of the visiting team at USC games should sit in sections 101-102, 200-202, and 300B-302. LA Coliseum also offers reserved seats for students in sections 123A - 127 and 225A - 228. Partying and socializing options are available in sections 123A, 123B, 124A and 124B. Founder suites can be found in 205-208. Below Founder suites, Log Box Seats are located as LB 400. 1923 Club is located in the 700 level between T9 and T4.
USC Trojans Bench: The bench is located in front of Sections 121 and 122.
Visitor Bench: Visitor team sit in front of Sections 107 and 106.
The USC Trojans and the Los Angeles Rams have unsold face-value tickets available for most games, which can be purchased directly through Ticketmaster. Prices may be above or below prices on the secondary ticket market. Many Concerts also have unsold tickets. For Sold Out Seats and Events, TicketIQ has Low Price Guarantees on all events at Center. That means that if you find a secondary market ticket for less on a site like StubHub or Vivid Seats, we'll give you 200% of the difference in ticket credit. TicketIQ customers save up to 25%.
NFL no longer supports home printed tickets for football leagues. You can buy mobile-only tickets either through the free Rams and USC mobile apps, Rams Account Manager on mobile web, or the Ticketmaster app. Through the Rams app you can download your tickets as well as manage your tickets – resell, forward or transfer.
LA Coliseum offers other convenient services including wheelchair assistance, lost and found and wheelchair check in. For guests who wish to transfer to a seat from their wheelchair, the seating arena will store the wheelchair at Guest Services on the 104-109 and 213-224.


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How to Create a Multiplane
In live action, when the camera moves through the scene, objects near the camera will move by a greater distance than objects far from the camera. In 2D animation, multiplanes can be used to achieve a similar effect without resorting to 3D backgrounds.
In Harmony, a multiplane can be easily achieved by creating a scene's background over several layers, and positioning them at different depths relative to the camera.
Before creating a multiplane, make sure you have a proper understanding of the environment in which your scene happens. Picture what your scene's background would be like in 3D, then image the camera moving through the space, and how the objects in the picture move at different speeds depending on where they are in relation to the camera lens.
In the following example, the background is made of 6 different layers, each picturing an object that is at a different distance from the camera. On the left, you can see how each object is positioned relative to the camera, as if you were looking at them from the side. On the right, you can see how layers are positioned relative to each other as if you were looking at the scene from a corner. Below, you can see the scene from the camera's point of view.
In order to move a layer further from or closer to the Camera, you must change its position on the Z-axis. You can do this by moving a layer using the Transform Tool in the Side or Top views. You can also move a layer on Z-axis directly from the Camera View by holding Alt and dragging the layer up or down. Positioning your element closer to the camera makes them appear bigger, and moving them further makes them appear smaller. It is also possible to move elements on the Z-axis without affecting their apparent size by using the Maintain Size tool in the Advanced Animation toolbar.
It is a good idea to keep a Camera view open to see what your scene looks like while positioning elements in the Top and Side views.
Just like with other transformations, transformations on the Z-axis on a parent layer will also affect the apparent position on the Z-axis of its child layers. Therefore, a child layer's apparent position on the Z-axis can be affected by any of its parents. Once transformations on the Z-axis have been performed on several layers in a hierarchy, it may be difficult to keep track of which layers have been moved on the Z-axis and which ones have not. To help with this, it is possible to compare the selected layer's Z coordinate value with its apparent position on the Z-axis using the Coordinates and Control Point view or the Coordinate toolbar. Both these interfaces feature a field to tweak the layer's Z coordinate, which is independent from parent layers, as well as a field displaying the layer's cumulative Z coordinate, which is the sum of the Z coordinate of the selected layer with the Z coordinate of all its parents.
To enable the Coordinate toolbar, do one of the following:
- From the top menu, select Windows > Toolbars > Coordinate.
- Right-click on any visible toolbar and select Coordinate.
To enable the Coord. and Control Points view, do one of the following:
- From the top menu, select Windows > Coord. and Control Points.
- From any view already open, click the Add View button at the top-right corner and select Coord. and Control Points.


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Request For Customization :-
if you any need to customize in Vartika PST to MBOX Converter then you can send mail to our support team. email@example.com
VSPL PST to MBOX converter helps you to convert PST File to MBOX File without even having Outlook on your device and its supported Outlook 2016, 2013, 2010, 2007, 2003.
*Download free version to scan and preview items and saved 30 items form each Folder.
VSPL PST to MBOX Converter is a reliable Converter that provides safe conversion of MS Outlook data (.PST) files to Thunderbird, Spicebird, SeaMonkey or Netscape mailbox (MBOX).
Vartika PST to MBOX Converter allows you to convert all emails from an Outlook data file to MBOX file format. Only one PST file can be converted at a time and a single MBOX is created for the same. The Outlook to Thunderbird Converter will export the entire folder having emails in them like: Inbox, Outbox, Sent Items, Drafts, etc.
Vartika PST to MBOX Converter is a credible tool which provides the option to keep the folder hierarchy intact during the process to Convert PST files to MBOX. You can select "Yes" if you want to keep the hierarchy maintained, and if you do not want to maintain the folder structure then "No" option can be chosen.
With the help of Vartika PST to MBOX Converter when you load the Outlook PST file and click export, PST to MBOX Converter software will show you the complete data count for each folder. It will show the name of current folder which is being converted, its folder count and number of emails converted from it.
While you convert Outlook PST to Thunderbird MBOX format, Vartika PST to MBOX Converter software maintains complete data integrity. The Meta data associated with emails like: sent data, received date, to, Cc, Bcc, etc. is also retained. Also, the original formatting of emails and the crucial data in it will be maintained by this tool
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VSPL PST to MBXO Converter Software examine Outlook PST file and converting PST file to MBOX File in the most accurate way. if any software help visit software working video.Watch Video
if you any need to customize in Vartika PST to MBOX Converter then you can send mail to our support team. firstname.lastname@example.com
|Product Features
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|All Message Items
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Vartika Software Private Limited distribute discount coupons, vouchers and coupon codes with this app, which will allow you to incentivize online purchases and encourage visits to your online store by means of coupons that can be redeemed for discounts, gifts, offers and promotions. The coupon codes app will let you distribute unique alphanumeric codes to participants, which you upload to the tool. In order to obtain a code, coupon or voucher, users will be required to fill in an order form which can be fully customized by the administrator. if you want discount coupon code then mail us - firstname.lastname@example.com
Yes. We have 30day refund systems.- We are requested you please read refund policy- click here. we can provide refund accourding to refund policy.
We have online software license delivery systems. after complted process of order then you can get instant software license delivery on reqistered order email id. if you can not get license then check spam folder or directly contact with our sales team firstname.lastname@example.com
Yes. The demo version has been developed to work similar to the licensed version, but the saving feature has been save 30 Items from each Folders. You can preview the items retrieved from the your file but can save 30 items into all type of PST/EML/MSG/MBOX format or directly imported into Office365 Account or Live Exchage Server
PST to MBOX Converter Software helps users to convert PST to MBOX files
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Century Citation Club
Fri, 13 Apr 2012
Dr Gordon Reid a Senior Lecturer in the Physiology Department University College Cork has been welcomed to the Century Citation Club of the journal of Physiology
The Century Citation Club comprises research papers which attract over 100 citations within ten years of publication. This is an achievement that we certainly think is worth recognition and celebration: everyone knows that papers are more often cited for being right than for being wrong or boring (or both). One hundred citations represents a citation rate roughly twice the average and then maintained for a decade; these papers are exceptional, they have made their mark and changed their fields. Papers achieving Century Citation status since 2000 are entered below. New papers will be added as they reach a century. We hope you enjoy this new feature, and we are looking forward to many great Centuries to come! See link below


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Laminitis in Horses
Laminitis is a very painful and serious disease that can cause lameness in horses. The laminae is the support of the bony column in the foot. Once this supportive lining between the hoof wall and the bone becomes inflamed, it is called laminitis. There are two layers of laminae in the hoof. The sensitive laminae next to the bone, contains the blood, and the layer next to the hoof wall has no blood or nervous tissue and is called the insensitive laminae.
Major changes in normal gut bacteria produced when a horse eats too much grain, lush pasture or mares having retained placenta can cause laminitis.
Grass founder occurs most often, and is attributed to horses grazing lush spring or fall growth of cool season grasses. This growth is low in fiber and high in carbohydrates, or sugars. The fructans are chains of sugars made up of fructose molecules. Horses lack the enzyme enabling them to digest fructans, and they pass undigested to the hind gut, and undergo bacterial fermentation. Lactic acid is produced during fermentation, and effectively kills the normal hind gut bacteria. These dying bacteria release endotoxins, that are absorbed through the bloodstream, causing reduced blood flow to the laminae, and sometimes laminitis.
By limiting grazing during high growth periods, grain intake, having a regular feeding schedule, regular hoof trimming, vaccinations and deworming, horse owners can reduce the occurrences of laminitis.


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Smulyan Gets Plug from Cuomo
Emmis Communications Corp. chairman Jeff Smulyan got some moral support from former New York Gov. Mario Cuomo for his effort to convince broadcasters to pool some of their digital spectrum for an over-the-air multichannel service that would compete with cable.
"If anybody's going to discover the future of broadcasting, it's Jeff Smulyan," said Cuomo, host of Broadcasting & Cable's Hall of Fame Awards this year.
Other inductees included WNET/Thirteen CEO William Baker, ESPN/ABC Sports President George Bodenheimer, Comcast Cable President Stephen Burke, Radio One Chairperson Catherine Hughes, Univision star and Sabado Gigante host Mario Kreutzberger--a.k.a. Don Francisco, WBEB-FM President Jerry Lee, Discovery Communications CEO Judith McHale, Warner Bros. Domestic Television Distribution President Dick Robertson as well as the ESPN show SportsCenter.
The television industry's top news stories, analysis and blogs of the day.
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The launch of this new resto-lounge was on the 12th November and was inaugurated by Actress Mrunal Kulkarni. Also present was Mr. Pravin Tarde and a few luminaries from the Marathi film industry. The star studded evening also saw attendance from some eminent personalities that included corporators, MLAs and businessman. The resto-lounge features three dining areas, a rooftop restaurant, poolside dining area and a Lounge-Hexa Lounge.The restaurant is owned by three partners, Mr Kamlesh Soni, who runs the popular In Green Restaurant, Mr Yuvraj Sharma, the owner of the Popular Hotel on Sinhagad Road and Mr Mahendra Vyas, Owner of Nova Interior Solutions and Yogesh Furniture.The essence and flavors of these four cuisines are brilliantly captured with the exquisite collection of vegetarian food that has been specially brought to its patrons. The dishes being served at the restaurant share an intimate connection with the palates of people having visited or heard about these international cuisines, bringing an immersion of nostalgia and fondness. Diners at the restaurant can experience the colorful facets of the different cuisines through a feast full of tradition and modernity at the same time. The restaurant combines traditional Indian Cuisine with urban chic sophistication. This marriage of old and new offers diners a feel of modern India at best, providing an intimate international dining at its best. The restaurant features the cities first ever rooftop lounge with poolside dining and features an exclusive part area where it can host parties for over 200 people at a time. The restaurant will not only be serving a galaxy of lip smacking Indian Foods, but it will also be serving a delicious mix of Mexican, Italian and Chinese cuisine which will delight the taste buds of every food connoisseur.The resto-lounge is located above the Hotel Popular on Sinhagad Road.
Due to extra work required to remove the press-releases we have started charging $1.99 for press release removal.
Your press release will be removed in 24 hours, once the payment has been received.


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Upcoming Event
US Regulatory Risks for European Companies
|Tue. October 30, 2018
08:00 am - 10:30 am
!Yale Club
The U.S. Securities and Exchange Commission (SEC) and the U.S. Department of Justice (DOJ) continue to actively investigate and prosecute alleged misconduct by foreign-domiciled companies with business or financial ties to the United States.European companies need to understand the areas of legal risk and the best strategies for dealing effectively with U.S. regulators while balancing local regulatory concerns.
This interactive panel discussion will utilize fact-patterns drawn from actual cases and will focus on:
* Connections to the U.S. that could allow the SEC or DOJ to assert jurisdiction
* Key U.S. substantive law including financial accounting and disclosure laws, Foreign Corrupt Practices Act (FCPA), and anti-money laundering (AML) laws
* Best practices in conducting internal investigations and responding to regulatory inquiries
* Practical issues including data privacy, employment law and privilege
* Strategic considerations including self-reporting and cooperation with U.S. regulators and implementation of remedial measures
* Potential concurrent jurisdiction of European regulators
* What are the EU implications for some of these rules and what are possible conflicts with local laws?
* Rogier Raas, Partner, Stibbe
* James Walker, Partner, Richard Kibbe Orbe (moderator)
* Margot Laporte, Litigation Associate, Richard Kibbe Orbe
* Brad Mroski, Director, AlixPartners
8:00 AM - 8:30 AM - Check in/Networking
8:30 AM - 10:00 AM - Program


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- Home
- Aromatherapy
- Himalayan Bath Salt EPSOM Salt Enriched
- Home
- Aromatherapy
- Bath Salts
- Himalayan Bath Salt EPSOM Salt Enriched
Product Description
Pure Himalayan Bath Salts with 100% Pure Essential Oils
Revitalizing * Rejuvenating * Purifying
Directions: Dissolve 1/2 cup of bath salt in tub with running water. Relax for 15-20 minutes. Rinse. For external use only.
300 million years ago, a vast ocean covered the area that would become the Himalayan Mountain range. The salt from that unpolluted ocean was preserved as large crystal formations, which now yield the purest salt on earth. The pink, mineral-rich salt crystals are hand picked and hammer-crushed, then washed and sun-dried.
Certified Organic by Oregon Tilth
24 oz. Jar
Ingredients: Pure Himalayan Crystal Salt, Organic Lavender Oil, Organic Lavandin Oil, Organic Chamomile Oil and Organic Orange Oil
Buy 2 or more and get a 10% discount.
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Email plays a massive part in all our lives in both work and at home. There are 4.6 billion accounts worldwide but only 2.7 billion email users. Figures suggest that around 212 billion business emails are sent/received daily.
Feeling moody ?
We have all been there; you receive an email from a disgruntled person, it may be a customer, friend or supplier. As you read the email, you can feel yourself getting annoyed the more you read. Now, the sender could be acting negatively, but sometimes it can just be your own mood leading you to completely misreading your emails. You could be busy, tired, stressed, hangry, there are many reasons for it. Wouldn't it be great if you could reply without a negative mood tainting your response, resulting in an email you may not need to regret later.
We all know the usual advice to tackle this type of response.
- Don't start typing the response straight away, take a break.
- Make sure you are reading the email properly and not jumping to conclusions.
- To avoid your response being misinterpreted, keep your response short.
- Keep tense emails straightforward by avoiding jokes and sarcasm.
- Ask a colleague for support when trying to respond to a tense email.
Sometimes these are easier said than done and what do you do when no one else is around when you need that help.
So what have we built ?
Imagine if you could get a mood score for emails you send and receive. Having a quick way to check what you are about to send taking your bias emotion out of the situation or you receive an email by removing your current mood. We built 'Should I Send It', what is it?
It is a free Google Chrome Extension which you install via the Chrome web store, then when your writing your emails just highlight the text to find out your sentiment result:
- Good to send.
- Neutral, OK to send.
- Negative, review before sending.
Using this tool will help improve your email writing by highlighting emails you send which may appear to sound negative, over time training you to automatically write more positively. However, there is one thing to bear in mind which is that although you may have had a negative score, it doesn't necessarily mean that you need to re-write it. You need to be conscious of it and make changes where needed.
Why should you use 'Should I Send It' ?
Everyone benefits, the recipient of the email, the person sending the email and the business. The tool can be used for both sending and receiving. As the receiver you get a positive response back to their email, the sender can use the tool to be proactive and correct behaviours when email writing. The business benefits in improved customer service, better-trained staff and empowered staff which all play a part in improving revenue.
- The chrome extension doesn't read the content of your web pages.
- The chrome extension only reads your highlighted text when you click the extension smile icon.
- Your highlighted text is passed from your browser to our API where the sentiment is calculated, we do not store in any way the text you highlight.
What's next
We have many ideas of how to push this tool forward as we all know how vital communication is within a business. Just imagine how much you could improve your email writing if you were getting a weekly report on your tone progress, just like you do for your fitness wearable.
'Should I Send It' currently is only supported in English, should we be supporting other languages?
Do you want this tool in your language? If so get in touch and let us know.
Get involved. Install the extension and start using it. We would love to know how you get on and any candid feedback you have though maybe use 'Should I send it' before you email us 😊


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Examination Schedule
Ph.D Entrance Results
Examination Schedule
Ph.D Entrance Results
The Library subscribes to more than 150 international journals annually and there journals. The primary mission of the library is to support
The educational and research programs of the
medical institute and medical students by
providing access to information that is
consistent with the present and anticipated
educational and research functions of the
Pacific Medical University under the aegis of Tirupati Balaji Educational Trust. It is spread over an area of 32.14 acres, beautifully landscaped and, surrounded by lush green hills of Bhillo Ka Bedla Pratappura, Udaipur (Raj), a 'B' class city on National Highway 27.
The college campus has spacious, well-designed and
properly furnished separate hostels for boys and girls;
including different ones for under graduate and
postgraduate students,Teaching and Non teaching staff
quaters. Each hostel room is well furnished with double
bed, study table, wardrobes and has an attached bath and
toilet, with 24 hours hot water supply.
Bhilon ka Bedla,Pratap Pura,Udaipur
Ph: 0294-3520000
Email: email@example.com
Website: www.pacificmedicaluniversity.ac.in
Pacific University


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SAN FRANCISCO, CA – Today, LiLoE Labs unveils a solution for the "Billion Dollar problem" of e-commerce package theft and damage through the debut of its Smart Mailbox, Hello Jeffrie. Last year in the US, over 50 million online consumers experienced a delivery disruption of sorts, by either an alternate location pickup, doorstep theft, or package damage due to mishandling or bad weather. The cost? Over 1.6 Billion dollars in retail product replacement.
Hello Jeffrie is a smart mailbox used to collect mail and keep packages safe from theft, food spoilage, and weather damage. Hello Jeffrie is non-permanent, can easily hang over any front door, and notifies consumers when their package has been delivered.
Hello Jeffrie's parent company, LiLoE Labs, is a recent graduate of FedEx's EPIcenter Logistics Accelerator and brings with it a team of diverse and talented individuals. "Our team has over 140 years of combined experience in logistics, hardware development, industrial design and mobile app development," said CEO Ashley Adewuyi. "We're really fortunate to have a people who have worked at places such as Amazon Fresh, the Navy, Booz Allen Hamilton, Universal Postal Union, FedEx, and UPS."
Hello Jeffrie is partnered with FedEx, and integrates the tracking information of major carriers, such as UPS and DHL, to provide live tracking from Hello Jeffrie's mobile app.
Consumers around the world can pre-order Hello Jeffrie today for $99.00 on Kickstarter. Orders will begin shipping in September 2017.
About Hello Jeffrie:
Jeffries mission is to reduce package theft in neighborhoods while providing peace of mind for e-commerce shoppers and on-demand users.
Media Contact
Company Name: LiLoE Labs
Contact Person: Ashley Adewuyi
Email: firstname.lastname@example.com
Country: United States
Website: https://www.kickstarter.com/projects/1644119687/jeffrie-protect-your-packages-w-the-smartest-mailb