text:
Recently I did a few tests with CloudFlare. My goals were to see how it would affect performance on my site and what other noticeable effects it would have. One thing that I had to cope with is the fact that visitors to my site no longer had a unique IP address. Since CF worked as a CDN/Proxy in my case, it resulted in everybody having the same IP: CF's. This is how I worked around that nuisance:
By default CF passes all HTTP headers as is from the client to origin. There are two exceptions, one of which we will use to determine the original IP from our visitors. This header is placed there by CF and holds each visitor's IP address. This way we can see the different visitors again. All we need to do is extract that information and do something useful with it. The exact way this process works is shown at CF's support environment. To make this work we can use the following code in our web.config:
What this does is look for a HTTP header CF_CONNECTING_IP, read its contents and set the REMOTE_ADDR value accordingly. This way your website can use the correct values for the visitor's IP addresses. Enjoy!


text:
Free Online Temporary Phone Numbers
Your privacy is important. quackr allows you to use a temporary VOIP number instead of your real phone number on the internet. Use our service to receive SMS Online instantly.
We take pride in our platform. Our virtual numbers are updated every month so make sure to bookmark us and check back for the latest numbers. Our service is always completely free and there is no sign-up needed.
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A temporary (or disposable) phone number is one which you do not own but can use it to receive SMS/text messages. Some providers will let you send messages but this usually incurs a cost.
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They protect your identity, it means you do not have to provide your real phone number when signing up to apps or services. They also prevent SMS spam.
Are temporary phone numbers free?
Yes, there are a number of free providers such as Quackr.io that allow you to use a temporary phone number to receive SMS.
I used a temporary phone number but didnt receive any SMS, why?
Many temporary phone number providers use VOIP numbers - companies are catching onto this and are actively blocking users from using VOIP numbers when signing up to services.
How much does quackr cost?
quackr will always offer a free service. On top of our free offering, we are planning to include a premium paid service where you can purchase your own dedicated anonymous phone number that only you have access to! Interested? Let us know.
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This varies depending on what's available - we try to have as many numbers from different locations as possible.
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Numbers get rotated at least every 30 days.
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Nope. All you need is an awesome browser like Google Chrome. Check out the latest version.
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No you do not need any software. quackr is a progressive web app that is accessible from any device.
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You can use quackr for setting up accounts on Facebook, WhatsApp, Gumtree, PayPal, Uber, Hike, Tencent, Cryptocurrency exchanges & much more!
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We currently have numbers for the following countries: United States, United Kingdom, Canada, Italy, Sweden, Switzerland, India, China & Pakistan. We plan to add more very soon!
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This depends on the external website sending the text message. If there is a delay it may take longer than 10 minutes to arrive. quackr uses VoIP technology, some websites/applications actively block VoIP numbers from receiving SMS. Rest assured - as soon as the message arrives, quackr will display it.
Let us know what you think
Comments? Suggestions? Improvements? Contact us.

subset: commoncrawl


text:
Heidolph North America's focus is on providing unparalleled sales & support of premium lab equipment. Heidolph's product lineup includes a full range of chem & bio tools designed to increase lab productivity. Heidolph equipment is made in Germany, backed by a 3-year warranty, and carries an average 10-year lifespan; making it a worthwhile investment.
Precise setting of rotation speed and heating bath temperature on the digital touch display or - for quick access during an active process - directly via the knobs on the operating panel.


text:
Separate names with a comma.
Discussion in 'Bolt Action' started by Anonymous, Apr 25, 2004.
Does anybody shoot one of these? I have 2 of them. 30/30,.222.
I have one in 30/30 it is a great shooter. It was given to me by a friend and it was in a bad way with rust but the barrel rifling was in good shape so I went to work on the rust and then reblued the complete rifle. It is a show thing now and it is a great shooter. There are a lot of parts around for it so repair is easy. I hope you have as much fun with yours as I have with mine.
i had a 340 in 30/30 when i was a kid in the '50s. i loaded for it, and it was accurate. i liked that old gun, too bad they are long discontinued.
These and the Stevens 325 in 30/30 are some of my favorite starter deer rifles. I've bought 5 of them so far for nieces and nephews and I hope to get one for myself some day. They are accurate, light, and can be found very reasonable. I buy them every chance I get. With 150 grain spitzer reloads and a scope, they easily take deer out to 200 yards or so. The only negative is that I have run across three that had excessive headspace, enough that the primers were partially backing out. Those three were stripped of parts and destroyed as correcting the problem costs more than a new gun.
"Guest"...sign up and join us...
I wish I owned your 340 in tripple duce, and you had a better one... :wink:
Would not mind having one or two or one of each myself. The 340 is a nice piece and I would not mind being able to pick one up in 30-30. Anyone know the availability of 340's at the gun shows? Never see any on the used rack.
I had one on 22 Hornet. Worst gun I ever owned. The think wouldn't cycle rounds. Tried a new clip, but to no avail.
Shot around corners too.
Just a plain piece of junk for me.
I think I gave it away, or possible I through it away. I can't recall.
I always wanted a 340, especially in .222, but never did get one.
as far as 222 goes i always like my dad swift first production 222
only got to shot it once and dang you could drive tacks with that things.
straightest shooting, most consistant gun i ever saw in my life
you could put a 5 shot group in a spot the sixe of your thumb nail and i am not bench rest shooter so i was in total aww.
that however was the one and only time he ever let me shoot it so it sits in the safe looking pretty and getting no action.
but from what i have been told there is a very good reason for that.
mind you and i quote
" guns are made to be used as long as their not abused"
and he let me as a 16 year old use a winchester 1894 made in 1906 but as a knowledgable adult he wont let me touch that thing for the life of me.
I had one in triple deuce, and wish I hadn't got rid of it.
If I did my part, it would shoot just under 1/2" @ 100yds with 52gr match bullets, and the best part was that it wasn't fussy about which match bullet.


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Buy Cardano
One of the best altcoins on the market right now is Cardano. But what exactly is Cardano (ADA)? Well, it's a smart contract platform that's based on peer-reviewed academic research. Using a two-layer system, Cardano's Blockchain solution is not only efficient but also flexible.
Given the current calls for safer systems that more businesses can tap into, this is a very good time to buy Cardano. Let's take a closer look at why and how to buy Cardano. We'll also explain where we've found the best place to buy Cardano is, and how to use the platform.
Buy Cardano
Why Buy Cardano Now?
But why is now the time to buy Cardano? For those in the know, there are a myriad of reasons, many of which are explained in our guide to Cardano. However, we don't need to delve into the technicalities of this cryptocurrency to answer the question "should I buy Cardano"? Firstly, the Cardano Settlement Layer (CSL) is a more efficient ledger than Bitcoin. When you consider how much of an influence Bitcoin's Blockchain protocols have already had on the world, it's easy to see why an upgraded system would be just as popular - if not more.
Secondly, the current price of Cardano is low. Unlike the price of Bitcoin, which is still in the five-figure range, Cardano coins (ADA) are trading for less than $1 at the moment. Naturally, this won't always be the case. However, if you get in early, there's a lot of margin for growth.
What is the Best Site to Buy Cardano?
What's the best place to buy Cardano? Through our in-depth research, we've concluded that broker eToro is currently the best option for buying Cardano. eToro is licensed and regulated by the Financial Conduct Authority (FCA) and CySEC.
In practical terms, this means the software meets certain safety standards and the company's business practices are monitored on a regular basis. In other words, when you opt for buying Cardano at eToro, you can be sure your money is safe. For example, when you look at our Binance review, you'll see it's only been around since 2017. In contrast, eToro has been active since 2006 and currently serves over 6 million users. Clearly, eToro has had more time to refine and perfect its product.
Additionally, eToro allows you to invest even if you're not an expert. Using a social trading function called Crypto CopyFund, you can copy the trades made by successful prow at a level that's suitable for your bankroll. There is also plenty of opportunity to learn through guides and even forums.
How to Buy Cardano with eToro
If you agree that eToro is the best place to buy Cardano, the next step is finding out exactly how to buy Cardano on eToro.
Step 1: Open an Account with eToro
Time to create an account at eToro. If you're unsure about what the site offers, you can read our eToro review. Our secure eToro sign-up link will take you directly to the registration page where you can join using your Facebook or Google accounts.
If you don't do that, you'll have to input a few personal details (name, email address etc) and then accept the terms and conditions.
Next, verify your identity using official ID and complete your profile.
Step 2: Deposit Funds
When you've registered your account, click the "deposit funds" button and choose one of the following secure payment options:
- Visa
- Maestro
- MasterCard
- Diners Club
- PayPal
- Skrill
- Wire Transfer
- Neteller
- Union Pay
- WebMoney
- Yandex
After selecting your payment method, choose your native currency and then input a deposit amount.
Step 3: Buy Cardano
Now you're ready to get some Cardano, type "Cardano" in the search box.
Choose how much you want to stake and then hit the "open trade" button.
This will invest your money at the current Cardano buy price and leave the trade open until you decide to end it.
How to Buy Cardano Through Exchanges
Buying Cardano at Binance
You can also buy Cardano at Binance. Binance is one of the largest exchanges out there, which means liquidity is never an issue. As you'll read in our Binance review, this is a crypto-only exchange. In fact, Binance was actually built using cryptocurrencies, thanks to an ICO. If there's one issue with this option, it's the fact you can't make a deposit using fiat currencies (GBP, USD etc). However, once you've credited your account, the Binance interface is user-friendly and the transaction fees are low.
Binance pros: Easy to use, high liquidity, low fees, strong security features
Binance cons: Unregulated, crypto-only deposits
Open account with Binance
- Visit the site and register for an account. - Make a deposit. - Find ADA using the search box and purchase the desired number of credits.
eToro Vs Exchanges
|Regulated by FCA and CySEC.
|No official regulations for exchanges at this time.
|Suitable for beginners thanks to the social trading feature.
|More suited to experienced traders.
|You can use a variety of payment options such as Visa, Neteller and PayPal to deposit using fiat currencies.
|You can usually only buy Cardano using another cryptocurrency.
|Has been active for more than a decade.
|Most crypto exchanges are less than five years old.
|Multiple investment options, such as forex and stocks, so you can spread your risk.
|Exchanges only offer cryptocurrency investments.
|Better customer service.
|Smaller companies which tend to struggle with customer support.
Buying Cardano: Payment Methods
Credit Card & Debit Card
For credit card payments and debit card transactions, the main benefits for crypto users are accessibility and protection. Because you're sending money directly from your bank account, the transaction is quick and efficient. Additionally, because Visa and MasterCard are highly regulated, you'll have a high level of protection when you use these methods to get Cardano. These methods are both available at our preferred broker for 2019, eToro.
If you prefer to use an e-wallet, PayPal payments are the best option. Aside from being the largest online payment processor, it also has some of the best security measures. In fact, it is because the eToro platform offers PayPal, in addition to Neteller and other options, that many investors prefer it. When you combine this with almost instant transactions and low fees, it's easy to see why PayPal is one of the best ways to buy Cardano online.
How to Buy Cardano in Your Country
As the cryptocurrency industry evolves, countries around the world are starting to find their own ways of regulating it. Because of this, you need to know how to buy Cardano in your respective region. The easiest way to do this is to click on the relevant country link below and find out how to buy Cardano where you live.
- Best Exchanges in the UK
- Best Exchanges in the US
- Best Exchanges in Australia
- Best Exchanges in India
- Best Exchanges in South Africa
How to Store Cardano in a Wallet
Once you've acquired some Cardano coins, you'll need a place to keep them. In general, there are four main places you can store your funds:
- Inside an exchange: This is the least secure option but it does allow you react to changing market conditions a lot faster.
- An online wallet: This option provides you with a secure online account. Naturally, it is encrypted and you'll need various passwords to access your account. This is generally considered the best place to store small to medium amounts of Cardano.
- A hardware wallet: If you want the safest option of all, you can purchase a hardware wallet. If you read through our guide to cryptocurrency wallets, you'll see that the Ledger Nano S is one of the best products out there. Although it takes longer to move your funds around, these wallets store your money offline, which is great if you own a lot of Cardano.
- Use a brokerage: The final way to store Cardano is to not own any in the first place. When you use the eToro broker, you're investing in the price of the asset and not the asset itself. This means you don't have to worry about buying Cardano and then moving it somewhere safe. Instead, you can simply buy and sell at the best prices without having to get your hands dirty.
Other Ways to Get Cardano
Before we let you go, we want to tell you how to buy Cardano without actually buying it. Like all cryptocurrencies, there are options and offers out there. In our opinion, coin mining is the best way to get Cardano without actually buying it.
Because Cardano is slightly different to Bitcoin, it isn't created or mined in the same way. However, you can contribute to the proof of stake system. In simple terms, a node in the network is chosen to solve an equation to process the payments, similarly to Blockchain. Because the system is random, you may have to wait until your node is selected and, therefore, rewarded. This system can certainly work, but only if you're an expert with cryptocurrencies. If you're anything less than that, it's better to buy Cardano via eToro.


text:
Justin Bieber and Hailey Baldwin are married or are they? This week, both TMZ and PEOPLE magazine confirmed that the lovebirds wed in a New York City courthouse and Selena Gomez has the best reaction to the news.
A source told PEOPLE: "They went ahead and did it without listening to anyone."
Many witnesses spoke to the reliable outlets and confessed to seeing Hailey and Justin going and exiting the courthouse's Marriage Bureau.
The insider said they got married without a prenup and added: "They didn't tell anyone on their teams what was going on and his people have been frantically trying to get his business affairs and finances in order."
Justin's net worth is around $170 million. According to TMZ, the power couple is planning a big wedding next week in Justin's native country, Canada.
The source shared Justin recently bought a massive $5 million estate on 101 acres in Ontario for the event.
According to Hollywood Life, Selena had an epic reaction to the news.
Their source claimed: "Actually, she was emotional but happy to hear about the marriage. Now, she feels like she can FINALLY move on."
The pal went on to reveal: "It is like even though Justin was with Hailey, Selena thought there was still a chance they would split and that he would get back together with her. It held Selena back from finding love herself."
The source added: "Now, Selena knows it's over once, and for all, so she feels relieved weirdly. Although it has been painful, even heartbreaking at times, the [reports] of Justin's marriage means Selena can finally close that chapter and start to focus on herself really. She fought back the tears and was shocked at hearing the marriage news, but is dealing with it and finding the positive side of things. She is finally ready to move on."
Hailey did jump on social media to address the wedding news by saying: "I understand where the speculation is coming from, but I'm not married yet!"
Celebrities have a habit of lying about marriages and pregnancies to keep them private, so Hailey might be doing just that.


text:
This service enables Contractors & Consultants to enroll in the DEWA e-Services System and obtain DEWA online Services.
5 working days.
Online Application Submission
Fill-in the online application form with required information. Attach required documents and submit the application:
List (2012-August, File Size: 120 Kb) of required attachments
Application Notifications
You will receive SMS and e-mail notifications regarding the progress of the application (submission, rejection, approval).
Service Delivery
Once the application is Approved, confirmation will be sent and username will be activated.


text:
This article will be permanently flagged as inappropriate and made unaccessible to everyone.
Are you certain this article is inappropriate?
Excessive Violence
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Reproduction Date:
Glucocorticoids (GCs) are a class of steroid hormones which bind to the glucocorticoid receptor (GR),[1] that is present in almost every vertebrate animal cell. The name glucocorticoid (glucose + cortex + steroid) derives from its role in the regulation of the metabolism of glucose, its synthesis in the adrenal cortex, and its steroidal structure (see structure to the right). A less common synonym is glucocorticosteroid.
GCs are part of the feedback mechanism in the immune system that turns immune activity (inflammation) down. They are therefore used in medicine to treat diseases caused by an overactive immune system, such as allergies, asthma, autoimmune diseases, and sepsis. GCs have many diverse (pleiotropic) effects, including potentially harmful side effects, and as a result are rarely sold over the counter.[2] They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to treat cancer. This includes mainly inhibitory effects on lymphocyte proliferation (treatment of lymphomas and leukemias) and mitigation of side effects of anticancer drugs.
GCs cause their effects by binding to the glucocorticoid receptor (GR). The activated GR complex, in turn, up-regulates the expression of anti-inflammatory proteins in the nucleus (a process known as transactivation) and represses the expression of proinflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus (transrepression).[2]
Glucocorticoids are distinguished from mineralocorticoids and sex steroids by their specific receptors, target cells, and effects. In technical terms, "corticosteroid" refers to both glucocorticoids and mineralocorticoids (as both are mimics of hormones produced by the adrenal cortex), but is often used as a synonym for "glucocorticoid." Glucocorticoids are chiefly produced in the zona fasciculata of the adrenal cortex, whereas mineralocorticoids are synthesized in the zona glomerulosa.
Cortisol (or hydrocortisone) is the most important human glucocorticoid. It is essential for life, and it regulates or supports a variety of important cardiovascular, metabolic, immunologic, and homeostatic functions. Various synthetic glucocorticoids are available; these are used either as replacement therapy in glucocorticoid deficiency or to suppress the immune system.
Glucocorticoid effects may be broadly classified into two major categories: immunological and metabolic. In addition, glucocorticoids play important roles in fetal development and body fluid homeostasis.
As discussed in more detail below, glucocorticoids function through interaction with the glucocorticoid receptor:
Glucocorticoids are also shown to play a role in the development and homeostasis of T lymphocytes. This has been shown in transgenic mice with either increased or decreased sensitivity of T cell lineage to glucocorticoids.[3]
The name "glucocorticoid" derives from early observations that these hormones were involved in glucose metabolism. In the fasted state, cortisol stimulates several processes that collectively serve to increase and maintain normal concentrations of glucose in blood.
Metabolic effects:
Excessive glucocorticoid levels resulting from administration as a drug or hyperadrenocorticism have effects on many systems. Some examples include inhibition of bone formation, suppression of calcium absorption (both of which can lead to osteoporosis), delayed wound healing, muscle weakness, and increased risk of infection. These observations suggest a multitude of less-dramatic physiologic roles for glucocorticoids.[3]
Glucocorticoids have multiple effects on fetal development. An important example is their role in promoting maturation of the lung and production of the surfactant necessary for extrauterine lung function. Mice with homozygous disruptions in the corticotropin-releasing hormone gene (see below) die at birth due to pulmonary immaturity. In addition, glucocorticoids are necessary for normal brain development, by initiating terminal maturation, remodeling axons and dendrites, and affecting cell survival[4] and may also play a role in hippocampal development.
Glucocorticoids act on the hippocampus, amygdala, and frontal lobes. Along with adrenaline, these enhance the formation of flashbulb memories of events associated with strong emotions, both positive and negative.[5] This has been confirmed in studies, whereby blockade of either glucocorticoids or noradrenaline activity impaired the recall of emotionally relevant information. Additional sources have shown subjects whose fear learning was accompanied by high cortisol levels had better consolidation of this memory (this effect was more important in men). The effect that glucocorticoids have on memory may be due to damage specifically to the CA1 area of the hippocampal formation. In multiple animal studies, prolonged stress (causing prolonged increases in glucocorticoid levels) have shown destruction of the neurons in this area of the brain, which has been connected to memory performance.[6][7][8]
Glucocorticoids have also been shown to have a significant impact on vigilance (attention deficit disorder) and cognition (memory). This appears to follow the Yerkes-Dodson curve, as studies have shown circulating levels of glucocorticoids vs. memory performance follow an upside-down U pattern, much like the Yerkes-Dodson curve. For example, long-term potentiation (LTP; the process of forming long-term memories) is optimal when glucocorticoid levels are mildly elevated, whereas significant decreases of LTP are observed after adrenalectomy (low-GC state) or after exogenous glucocorticoid administration (high-GC state). Elevated levels of glucocorticoids enhance memory for emotionally arousing events, but lead more often than not to poor memory for material unrelated to the source of stress/emotional arousal.[9] In contrast to the dose-dependent enhancing effects of glucocorticoids on memory consolidation, these stress hormones have been shown to inhibit the retrieval of already stored information.[10] Long-term exposure to glucocorticoid medications, such as asthma and anti-inflammatory medication, has been shown to create deficits in memory and attention both during and, to a lesser extent, after treatment,[11][12] a condition known as "steroid dementia."[13]
Glucocorticoids could act centrally, as well as peripherally, to assist in the normalization of extracellular fluid volume by regulating body's action to atrial natriuretic peptide (ANP). Centrally, glucocorticoids could inhibit dehydration induced water intake;[14] peripherally, glucocorticoids could induce a potent diuresis.[15]
Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus.[16]
Glucocorticoids bind to the cytosolic glucocorticoid receptor (GR), a type nuclear receptor that is activated by ligand binding. After a hormone binds to the corresponding receptor, the newly formed complex translocates itself into the cell nucleus, where it binds to glucocorticoid response elements (GRE) in the promoter region of the target genes resulting in the regulation of gene expression. This process is commonly referred to as transcriptional activation, or transactivation.[17][18]
The proteins encoded by these up-regulated genes have a wide range of effects, including, for example:[18]
The opposite mechanism is called transcriptional repression, or transrepression. The classical understanding of this mechanism is that activated GR binds to DNA in the same site where another transcription factor would bind, which prevents the transcription of genes that are transcribed via the activity of that factor.[17][18] While this does occur, the results are not consistent for all cell types and conditions; there is no generally accepted, general mechanism for transrepression.[18]
New mechanisms are being discovered where transcription is repressed, but the activated GR is not interacting with DNA, but rather with another transcription factor directly, thus interfering with it, or with other proteins that interfere with the function of other transcription factors. This latter mechanism appears to be the most likely way that activated GR interferes with NF-κB - namely by recruiting histone deacetylase, which deacetylate the DNA in the promoter region leading to closing of the chromatin structure where NF-κB needs to bind.[17][18]
Activated GR has effects that have been experimentally shown to be independent of any effects on transcription and can only be due to direct binding of activated GR with other proteins or with mRNA.[17][18]
For example, Src kinase which binds to inactive GR, is released when a glucocorticoid binds to GR, and phosphorylates a protein that in turn displaces an adaptor protein from a receptor important in inflammation, epidermal growth factor (EGF), reducing its activity, which in turn results in reduced creation of arachidonic acid - a key proinflammatory molecule. This is one mechanism by which glucocorticoids have an anti-inflammatory effect.[17]
A variety of synthetic glucocorticoids, some far more potent than cortisol, have been created for therapeutic use. They differ in both pharmacokinetics (absorption factor, half-life, volume of distribution, clearance) and pharmacodynamics (for example the capacity of mineralocorticoid activity: retention of sodium (Na+) and water; renal physiology). Because they permeate the intestines easily, they are administered primarily per os (by mouth), but also by other methods, such as topically on skin. More than 90% of them bind different plasma proteins, though with a different binding specificity. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called corticosteroid-binding globulin), whereas all of them bind albumin. In the liver, they quickly metabolize by conjugation with a sulfate or glucuronic acid, and are secreted in the urine.
Glucocorticoid potency, duration of effect, and the overlapping mineralocorticoid potency vary. Cortisol (hydrocortisone) is the standard of comparison for glucocorticoid potency. Hydrocortisone is the name used for pharmaceutical preparations of cortisol.
The data below refer to oral dosing, except where mentioned. Oral potency may be less than parenteral potency because significant amounts (up to 50% in some cases) may not be absorbed from the intestine. Fludrocortisone, DOCA (Deoxycorticosterone acetate), and aldosterone are, by definition, not considered glucocorticoids, although they may have minor glucocorticoid potency, and are included in this table to provide perspective on mineralocorticoid potency.
Glucocorticoids may be used in low doses in adrenal insufficiency. In much higher doses, oral or inhaled glucocorticoids are used to suppress various allergic, inflammatory, and autoimmune disorders. Inhaled glucocorticoids are the second-line treatment for asthma. They are also administered as post-transplantory immunosuppressants to prevent the acute transplant rejection and the graft-versus-host disease. Nevertheless, they do not prevent an infection and also inhibit later reparative processes. Newly emerging evidence showed that glucocorticoids could be used in the treatment of heart failure to increase the renal responsiveness to diuretics and natriuretic peptides.
Any glucocorticoid can be given in a dose that provides approximately the same glucocorticoid effects as normal cortisol production; this is referred to as physiologic, replacement, or maintenance dosing. This is approximately 6–12 mg/m²/day of hydrocortisone (m² refers to body surface area (BSA), and is a measure of body size; an average man's BSA is 1.9 m²).
Glucocorticoids cause immunosuppression, and the therapeutic component of this effect is mainly the decreases in the function and numbers of lymphocytes, including both B cells and T cells.
The major mechanism for this immunosuppression through inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB). NF-κB is a critical transcription factor involved in the synthesis of many mediators (i.e., cytokines) and proteins (i.e., adhesion proteins) that promote the immune response. Inhibition of this transcription factor, therefore, blunts the capacity of the immune system to mount a response.[2]
Glucocorticoids suppress cell-mediated immunity by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and IFN-γ, the most important of which is IL-2. Smaller cytokine production reduces the T cell proliferation.[21]
Glucocorticoids, however, not only reduce T cell proliferation, but also lead to another well known effect - glucocorticoid-induced apoptosis. The effect is more prominent in immature T cells still inside in the thymus, but peripheral T cells are also affected. The exact mechanism underlying this glucocorticoid sensitivity still remains to be elucidated.
Glucocorticoids also suppress the humoral immunity, thereby causing a humoral immune deficiency. Glucocorticoids cause B cells to express smaller amounts of IL-2 and of IL-2 receptors. This diminishes both B cell clone expansion and antibody synthesis. The diminished amounts of IL-2 also cause fewer T lymphocyte cells to be activated.
Since glucocorticoid is a steroid, it regulates transcription factors; another factor it down-regulates is the expression of Fc receptors on macrophages, so there is a decreased phagocytosis of opsonised cells.
Glucocorticoids are potent anti-inflammatories, regardless of the inflammation's cause; their primary anti-inflammatory mechanism is lipocortin-1 (annexin-1) synthesis. Lipocortin-1 both suppresses phospholipase A2, thereby blocking eicosanoid production, and inhibits various leukocyte inflammatory events (epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst, etc.). In other words, glucocorticoids not only suppress immune response, but also inhibit the two main products of inflammation, prostaglandins and leukotrienes. They inhibit prostaglandin synthesis at the level of phospholipase A2 as well as at the level of cyclooxygenase/PGE isomerase (COX-1 and COX-2),[22] the latter effect being much like that of NSAIDs, potentiating the anti-inflammatory effect.
In addition, glucocorticoids also suppress cyclooxygenase expression.
Glucocorticoids marketed as anti-inflammatories are often topical formulations, such as nasal sprays for rhinitis or inhalers for asthma. These preparations have the advantage of only affecting the targeted area, thereby reducing side effects or potential interactions. In this case, the main compounds used are beclometasone, budesonide, fluticasone, mometasone and ciclesonide. In rhinitis, sprays are used. For asthma, glucocorticoids are administered as inhalants with a metered-dose or dry powder inhaler.[23]
Glucocorticoids can be used in the management of familial hyperaldosteronism type 1. They are not effective, however, for use in the type 2 condition.
Resistance to the therapeutic uses of glucocorticoids can present difficulty; for instance, 25% of cases of severe asthma may be unresponsive to steroids. This may be the result of genetic predisposition, ongoing exposure to the cause of the inflammation (such as allergens), immunological phenomena that bypass glucocorticoids, and pharmacokinetic disturbances (incomplete absorption or accelerated excretion or metabolism).[21]
Glucocorticoids could be used in the treatment of decompensated heart failure to potentiate renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics.[24][25][26][27][28][29][30]
Glucocorticoid drugs currently being used act nonselectively, so in the long run they may impair many healthy anabolic processes. To prevent this, much research has been focused recently on the elaboration of selectively acting glucocorticoid drugs. Side effects include:
In high doses, hydrocortisone (cortisol) and those glucocorticoids with appreciable mineralocorticoid potency can exert a mineralocorticoid effect as well, although in physiologic doses this is prevented by rapid degradation of cortisol by 11β-hydroxysteroid dehydrogenase isoenzyme 2 (11β-HSD2) in mineralocorticoid target tissues. Mineralocorticoid effects can include salt and water retention, extracellular fluid volume expansion, hypertension, potassium depletion, and metabolic alkalosis.
Glucocorticoids cause immunosuppression, decreasing the function and/or numbers of neutrophils, lymphocytes (including both B cells and T cells), monocytes, macrophages, and the anatomical barrier function of the skin.[34] This suppression, if large enough, can cause manifestations of immunodeficiency, including T cell deficiency, humoral immune deficiency and neutropenia.
In addition to the effects listed above, use of high-dose steroids for more than a week begins to produce suppression of the patient's adrenal glands because the exogenous glucocorticoids suppress hypothalamic corticotropin-releasing hormone and pituitary adrenocorticotropic hormone. With prolonged suppression, the adrenal glands atrophy (physically shrink), and can take months to recover full function after discontinuation of the exogenous glucocorticoid.
During this recovery time, the patient is vulnerable to adrenal insufficiency during times of stress, such as illness. While suppressive dose and time for adrenal recovery vary widely, clinical guidelines have been devised to estimate potential adrenal suppression and recovery, to reduce risk to the patient. The following is one example:
Protein, Glucose, Glycolysis, Citric acid cycle, Ribose
Epidermis (skin), Water, Cell (biology), Connective tissue, Amphibians
Corticotropin-releasing hormone, Hypothalamus, Corticosterone, Progesterone, Cortisone
Gene, Metabolism, Dexamethasone, Gene expression, Developmental biology
Medicine, Science, Psychiatry, Cancer, Allergy
Corticosterone, Progesterone, Deoxycorticosterone, 17-Hydroxyprogesterone, Aldosterone
National Institutes of Health, Glucocorticoid, Asthma, United States National Library of Medicine, Aminoglutethimide
International Union of Pure and Applied Chemistry nomenclature, CAS registry number, PubChem, ChemSpider, Unique Ingredient Identifier
Progesterone, Dehydroepiandrosterone, Birds, Glucocorticoid, Pregnenolone
Testosterone, 17-hydroxyprogesterone, Androgen, Infertility, Intersex


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Revitalising a traditional enterprise by innovative ideas incorporated with social responsibilities, Alan is one of the outstanding entrepreneurs who combines creativity and business acumen in his pursuit of social innovation.
Alan actualised his concept with the innovative industrial project TML (To Make Locally), which is a synergy of an extended supply chain from Mainland China and Hong Kong's smart manufacturing practice. While enhancing productivity and responsiveness with the use of mobile app, digital printing and 3D printing, TML also aims to boost employment rate in the declining garment industry, support local fashion designers, and re-establish the once glorious "Made in Hong Kong" brand. At TML's studio, social impact is prevalent. Experienced garment workers are employed, bringing in their wealth of skills and expertise. Local designers are able to test the market of their ideas through small scale production. More importantly, young designers are connected to seasoned masters to provide them with the opportunity to share and retain the traditional wisdom of the apparel industry. The achievements of TML witness how the shared value is created through generating profits and facilitating the sustainable development of the industry and society at the same time.
While committed to promoting the concept of creating shared value among businesses, Alan is also working closely with social enterprises and NGOs in encouraging and supporting passionate social innovators to build social capital for the community.
- Alan shares his views on SIE Fund and the development of the social innovation ecosystem:
Scope of Services
Read more
- Alan Cheung devoted to incubating local designs (Sing Tao Daily 25/8/2018) (Chinese version only)
- SIE Fund promotes "Creating Shared Value" (on.cc news, 31/8/2015) (Chinese version only)


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by Ian Marshall, ITTF Publications Editor
It was to some extent for Maria Dolgikh a reversal of fortunes; earlier in the day, partnering colleague Polina Mikhailova and occupying the top seeded spot in the Women's Doubles competition, the duo had suffered an unexpected defeat at the hands of Luxembourg's Sarah de Nutte and Ni Xialian (10-12, 11-6, 11-8, 11-8, 11-3).
"I have beat Liu Jia a few times when I was much younger, seven or eight years ago but after that, seven times in the row she beat me. Last year in Top 16 she gave me no chance; for sure, I knew this is going to be a tough encounter; I practised to win short rallies. I know she would not let me play long points."
Second round Women's Singles success for Maria Dolgikh, there was also success for partner Polina Mikhailova, as there was for nemesis Ni Xialian, twice European champion.
"Li Fen wanted to finish the game quickly. I was not rushing," Maria Dolgikh
Like Maria Dolgikh, Polina Mikhailova caused Austria problems; she overcame Sofia Polcanova (13-11, 11-7, 9-11, 11-7, 9-11, 11-5); however, the result was no surprise. Polina Mikhailova started matters as the no.12 seed, Sofia Polanova, the no.18 seed.
"I started to receive better and I put more power in my service game in order to stay in the match", Polina Mikhailova
Success as anticipated; it was the same for Ni Xialian but it was hard fought success; the no.20 seed, she needed seven games to beat Polish qualifier, Klaudia Kusinska (9-11, 9-11, 11-4, 11-9, 11-5, 7-11, 11-7). A close call for Ni Xialian, it was the same for Fu Yu, the no.9 seed; she was extended the full distance by the Czech Republic's spirited Hana Matelova, the no.29 seed (9-11, 12-10, 4-11, 7-11, 11-4, 11-5, 11-3).
"Kusinska improved her game. She is so powerful player now. At my age it is hard to stay focused all the time. I made few silly mistakes. I gave easy points. However, I am still winning and I am enjoying the game." Ni Xialian
Testing times but for the other leading names life was less fraught with Germany enjoying more success.
Han Ying, the top seed, beat Portugal's Shao Jieni, the no.17 seed (11-3, 11-5, 5-11, 11-2, 11-4); Petrissa Solja, the no.2 seed, overcame the Slovak Republic's Barbora Balazova, the no.22 seed (11-5, 11-5, 11-7, 11-1), whilst Shan Xiaona, the no.3 seed, defeated Russia's Yulia Prokhorova, the no.30 seed (11-4, 11-6, 11-6, 11-6).
"I was not very confident today. I had an injury recently", Fu Yu
In a similar vein, Li Jie of the Netherlands, the no. 5 seed, accounted for the host nation's Szandra Pergel (11-6, 11-5, 11-3, 7-11, 11-3), whilst Turkey's Hu Melek, the no.6 seed, overcame Spain's, Sara Ramirez (11-5, 11-8, 11-7, 11-7), like Szandra Pergel a qualifier.
Defeat for Szandra Pergel but there was success for Hungary; Georgina Pota, the no.8 seed, defeated Romania's Irina Ciobanu (11-9, 11-8, 11-6, 11-5).
Progress for notable names there was advancement for one more; Romania's Elizabeta Samara, the no.7 seed and defending champion, ended the hopes of Spain's Galia Dvorak (11-9, 11-4, 11-5, 9-11, 13-11). Defeats for Irina Ciobanu and Galia Dvorak meant no player, who had started proceedings in the qualification stage, booked a third round place.
The third round and quarter-finals of the Women's Singles event will be played on Saturday 22nd October.


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My brother writes from Switzerland, where he lives. Occasionally, he writes of amazingly elegant and simple solutions that I think of as typically Swiss. It's a wonderful awareness of different problem-solving adaptations in different cultures. Here is the story:
"I was coming home [riding a bicycle] on a paved, two-lane-wide road without lane markers, common around here. I saw a road sign that signaled 'cow crossing,' but it was in an odd place and beat-up looking. I mistakenly assumed it had been left there by accident until I came upon the cows blocking the road and coming toward me.
I've mentioned before that the Swiss stake out fields that have been turned into pastures by putting frail poles strung with a single thread of electrified fence. The cows could easily walk through, but because
of the shock, won't. Thus, when farmers herd them down a street, they block of side streets with string, and the cows, mistaking it for electric fence, respect that.
Well, this herd was being herded down the street with string. The shoulder of the road was lined with electric fence. The farmer and his wife carried some string perpendicular to the road and to the fence
lining it. The farmer formed the corner, and his children and a farm worker brought up the rear, shaping the line of string into a rectangle. The cows carefully stayed within it as the group walked down the street toward the barn.
As they saw me coming, they narrowed the rectangle, freeing one lane for traffic, and I, and then one or two cars, passed through. The cows carefully stayed within the string."
A perfect example of elegant problem solving!
—Quinn McDonald loves innovation and ingenuity.


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Event has ended
Webinar logistics:
- When December 11th, 2018 at 10:30am CDT - 60 minutes
- How WebEx (see below)
- Audience New and experienced Discovery users and administrators
- Recording Yes, will be provided via this page afterwards
Webinar details:
As mentioned in blogs BMC Helix Discovery - Marketing Launch Announcement and Now Available! BMC Helix Cognitive Service Management (CSM) on Azure and Helix Discovery on AWS BMC's flagship application discovery and dependency mapping solution is now being offered as a cloud native SaaS offering under the Helix brand of BMC solutions! In this session, Antonio Vargas and Michael Traher will provide a deep dive on Helix Discovery providing insight into the offering and how it works.
We request the pleasure of your company
What do I do?
If you have questions you would like addressed, please post them below
WebEx meeting details:
Registration Link: https://bmcsoftware.webex.com/bmcsoftware/onstage/g.php?MTID=ecb00ec2dc41e8c6b1dd4fe249d9151e8
When and Where
Start Time:Dec 11, 2018 10:30 AM CDT (America/Chicago)
End Time:Dec 11, 2018 11:30 AM CDT (America/Chicago)
Event Info
Event Type:Webinar
Event Visibility & Attendance Policy:Open
Contact Info
- Antonio Vargas (Owner)


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At the end of WWI, when the
Palestine area came under British care, and Syria was placed under , the local Arabs, rather than seeing this as a step toward independence and freedom, felt the world had betrayed them, eliminating the "protection" they had gotten under Turkish rule. France
|City view taken by my niece during
this summer's semester abroad
During the next three decades, they developed agriculture, factories, roads, hydroelectric power, and tapped mineral resources. Cultural life abounded. Universities were formed. Art galleries and performance venues popped up, and there was lively discussion wherever people met to socialize. Also notable, the Hebrew language was revived as a living language, eventually developing vocabulary necessary for the modern world. Hebrew became one of three official languages, along with English and Arabic.
Meanwhile, the Arabic people of the region resisted progress and felt threatened by both the influx of Jewish people and also the progress they instigated.
World history would be different if this early working relationship had continued. Unfortunately, it didn't last.
The first anti-Jewish riots broke out on April 4, 1920, and continued igniting steadily over the next two decades.
From what I can ascertain, this date could identify the introduction of terrorism into the world. Also, from what I can find, every riot was instigated by Arabs against Jews, never the reverse. Nor was there retribution beyond trying to quell the violence and hold perpetrators accountable.
Yesterday we mentioned a couple of the reasons: Palestinian Arabs wanted to return to the older status quo. And they were upset that the malarial swampland and wilderness they had sold got turned into valuable farmland—and was no longer in their hands. But there were additional reasons. While Arab Muslims viewed the Bible as a sacred book, they did not accept as fact that the Jews had any divine right to the area Palestinian area.
And then there's the Dome of the Rock, one of the most sacred shrines in the Muslim world. It happens to be located on the site the Jews recognize as the historic location of Solomon's temple—which they intend to rebuild. Muslims consider this a threat to their sacred site.
The Zionists continued efforts to discuss the problems and reach an understanding with the Arabs, but they were unsuccessful. The British, as guardian of the region, first recommended in 1937 a two-state solution, one of Jews and one of Arabs. Jewish leadership considered the idea and decided to allow the Jewish Agency to negotiate for the proposal with the British government. The Arabs, however, absolutely and completely rejected any plan for partition.
During this period, underground movements developed among the Jews, a kind of defense militia: Haganah (founded 1920), Etzel (1931), and Lehi (1940). Some of their acts included retaliation for Arab attacks and sabotage, as well as demonstrations against British restrictions on immigration. The least restrained of these was Etzel. All were disbanded at the founding of the Israel Defense Forces in May 1948.
How to quell the continuing riots and attacks was an annoying concern to
. The most notable response was the series of directives issued in May 1939, called the White Papers, which severely restricted Jewish immigration to Eretz Britain —coinciding with the desperate need for Jews escaping from German Nazis to have a place of refuge. Nor did these restrictions appease the Arabs. Israel
Zionists remained consistent on two fronts: continue Zionist goals without compromise, and continue loyalty to
and the free world, despite what appeared to be a lack of loyalty in return. At the onset of WWII, David Ben-Gurion (who later became Israel's prime minister," put it this way: "We will fight the war as if there were no White Paper, and the White Paper as if there were no war." Britain
Tomorrow, in Part IV, we should get to the forming of the state of Israel.


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Weekly Reads: Nearly Halloween Edition
Happy almost-halloween, everyone! This week on Weekly Reads we have links to trans friendly children's literature (for reading , not…Read More »
What to Expect When Your Child is Trans*
Just in case it is not obvious, the post title is a spoof on What to Expect When You're Expecting.…Read More »
Internet Meme Demolition Derby: The Scourge of the Man Bun
Hello there! I hope everyone in the Northern Hemisphere had a happy Summer vacation. Summer is still kind of full…Read More »
Transgender Questions (2): physical transitions – getting the personal questions out of the way
In the first installment of this series, I mentioned my basic approach to and motivations for writing these posts. Just…Read More »
Transgender Questions (1): terminology and basics
I'd like to preface this new series by acknowledging that it is intended for general, non-trans* readers (although I absolutely…Read More »
Internet Meme Demolition Derby: The Bathroom Wars Part Two, The NOT HELPING Edition
(CN: Anti-Trans bigotry and some generally clueless allyship) Welcome back to the Bathroom Wars. If you read the first edition…Read More »
Potty Politics: Four things bathroom bill proponents get wrong
CN: Transphobia At the risk of making this the Grounded Bathrooms page for a little while here, I would like…Read More »
Bathroom Bonanza
(Consider this my minor contribution to Lou's excellent post on The Bathroom Wars.) I'm an engineer. In general, that means…Read More »
Internet Meme Demolition Derby: The Restroom Wars Part One…
(CN: Anti-Trans bigotry and threats of violence and just general horrible people being horrible, proceed with caution) According to prominent…Read More »
Dissipating Ghosts and Having a Transgender Child
Have you ever had the experience of walking into a dim room and seeing something that doesn't make sense at…Read More »


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The stylish new QWS WL 3 uses Firewall UV purification to wipe out impurities ensuring an optimal quality of water at whatever time you dispense. The innovative Firewall technology has been designed by us to purify drinking water, typically reducing any bacterial contamination by up to 99.9999%, and also acting as a barrier, maintaining the hygiene of the dispenser. Our unique design also results in a good capacity to provide hot, cold, ambient, or sparkling water, whenever you want it.
Our filtration technology is really good at taking the bad stuff out and leaving the good stuff in. This stage removes chlorine and other water-borne tastes and odors.
Next, an in-tank UV lamp purifies the water. UV light wipes out harmful bacteria such as E. Coli, Salmonella and Hepatitis to guarantee a safe, clean drink.
We've got the inside covered and the outside too. As another layer of defense, BioCote keeps the dispensing area free of bacteria.
- INTENSE UV PURITY- The design allows for higher UV exposure which reduces bacteria, viruses, and parasites that may be in the water, purifying up to 99.9999% of any pathogens 100% of the time.
- GOODBYE BACTERIAL- Point of dispense purification keeps the dispense nozzle free from external contamination as well as purifying the water as it fills your cup, making the freshest water possible
- DUAL CERTIFICATION- The Firewall technology has been tested and certified by the WQA to NSF/ANSI-5S Class A UV and NSF P231 protocol (coming soon), which is unique – no one else has these together. This means that Firewall delivers the cleanest, clearest water possible


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December on the blog has been really interesting for us. December is the month where we - and just about every other blog / publication / tv or music show out there - look back on the year that's passed and then write various posts about it. And we will be doing that...It's just that we've kind of … [Read more...]
Fethiye – Winter – Street Food – Istanbul – A Stream Of Thought
Istanbul Street Food – Black & White Series
Well isn't this a coincidence? Today's post is a series of black and white photos from Istanbul. It's not the first time we've done this. And there's the coincidence. On going back to our first Istanbul in Black and White post, it's become apparent that we published it exactly this time last year, … [Read more...]
Turkish Food: Honey, Nuts and Kriko
'EL-WAJ-EE, EL-WAJ-EE.' Stick around in any of the Fethiye bars and cafes for only a short amount of time and eventually, you will hear a male voice shouting something resembling that sound. This guy is a Fethiye institution; trundling up and down the harbour, around Fethiye Tuesday market and … [Read more...]
Fethiye Festivities – Sundial Hotel
We're getting there slowly; Christmas is creeping up on us really quickly and we're starting to feel the festive spirit really slowly. Yesterday helped us along the way very nicely though. Murat, the owner of the Sundial Hotel in Fethiye decided to play Father Christmas and invite people for an … [Read more...]


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Marijuana initiatives appeared on ballots in four states in the midterm elections. In Michigan and North Dakota, initiatives gave voters the opportunity to legalize marijuana for recreational use. In Missouri and Utah, voters chose whether to allow people who are sick to use the drug for medical reasons.
Here are the results of those initiatives.
Michigan voters legalized the sale and use of marijuana
Michigan became the first Midwestern state to legalize recreational marijuana, and the 10th state, in addition to the District of Columbia, to allow adults to possess the drug in small amounts for recreational use. Fifty-six percent of the state's voters cast ballots in favor of the measure.
In doing so, voters endorsed Proposal 1, the Michigan Regulation and Taxation of Marihuana Act, which permits people who are 21 or older to possess and grow cannabis and related concentrates for personal use. It also licenses commercial production and retail sales of marijuana.
Advocates of legalization said the measure would curb arrests and redirect tax money. The National Organization for the Reform of Marijuana Laws, which tracked the progress of the Michigan vote and the marijuana ballot initiatives in other states, said voters' approval of Proposal 1 was a "resounding rebuke" of the state's policy of prohibition and of its "racist application" of arrests. [Read More @ NY Times]


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Brussels, 11 Feb 2004
A new project on medical devices has been allocated over 16 million euro of Sixth Framework Programme (FP6) funding to fight such health problems as spinal cord injuries, vascular diseases, immunological diseases of the nervous system, incontinence, loss of sight and hearing impediments.
This Integrated Project comprising 26 partners, including six small and medium sized enterprises (SMEs), from eight different European countries and Israel, will be funded under the IST priority of FP6 over a four year period.
Dr Diana Hodgins, Managing Director of European Technology for Business (ETB) Ltd, who is coordinating the project, explained: 'it is estimated that around 50 per cent of the western population, i.e., around 500 million citizens, suffer from at least one of the health problems targeted in this project. Successful outcomes from this project will improve the quality of life for millions of EU citizens and the long-term cost of treating people will reduce significantly'.
The project aims to develop a cochlear implant; retina implant and glaucoma sensor; technology for providing functional electrical stimulation for upper and lower limbs; an artificial sphincter and sphincter sensor; an implantable pressure sensor to monitor intracranial pressure; an Inertial Measurement Unit (IMU) for human body motion, as well as key technologies to achieve these tools.
The consortium combines partners from a wide range of disciplines who are all experts in their fields and will take the new medical implants from concept to production. As the time from development to market is long, typically ten years, it is expected that some designs will have completed pilot clinical trials at the end of the project while others will be ready for trials.
For more information, please contact:
Diana Hodgins
European Technology for Business (ETB) Ltd
E-mail: firstname.lastname@example.com
Tel: +44 1438 822822
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Big Wave Earrings
Tax included. Shipping calculated at checkout.
This listing is for one pair of gorgeous light weight earrings. Earwire and circle are sterling silver.
Crystal is amazonite, this stone is known for its calming vibe.
Everyday wear!
Hang about 4" in length
Handmade in San Diego, CA.
First class shipping includes tracking number.


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The day you walked hand and hand down the aisle with your loved one remains one of the most important moments of your life. Once a year, on your anniversary, you celebrate that special day. Celebrate your love with a trip to remember in one of the world's most vibrant places, New York City. When planning your anniversary weekend in New York, stay at hotel that has the services and accommodations to fulfill all of your romantic wishes.
Step 1
Research hotels in New York and find one that has a romance package. Romance packages commonly consist of things like champagne, strawberries and chocolates, and vouchers for the restaurant and spa. A few hotels that offer romance packages include the Warwick Hotel, the Paramount Hotel and the Hilton Hotel.
Step 2
Find a hotel in a part of New York that is close to attractions. For a scenic backdrop to a romantic weekend, stay at a room overlooking Central Park. Rooms at the the Mandarin Oriental, which overlooks the park, have picture windows that stretch from floor to ceiling. To enjoy entertainment together, consider a hotel near Broadway, such as the Mansfield Hotel or the Marriott Marquis Hotel.
Step 3
Reserve a room that has a hot tub. Hotels often offer hot tub rooms specifically designed for romantic getaways, where guests can enjoy a fragrant bubble bath, private balconies and cozy fireplaces.
Step 4
Light candles, sprinkle rose petals in the tub and take a hot bubble bath together. A romantic nighttime soak will set the mood for the rest of the trip. Order room service that night for dinner and make the most of your alone time in your room.
Step 5
Stay in bed late your first morning there. Cuddle in the soft, fresh robes that the hotel provides and have breakfast delivered to the room for breakfast in bed.
Step 6
Have a day out together. See a musical at the Gershwin Theater or the Shubert Theater. Stroll around Greenwich Village, enjoy the street performers in Washington Park and visit the infamous Strand Bookstore. Take a romantic carriage ride around Central Park. Head to Pier 81 to board a sunset cruise and marvel at the view of New York from the water.
Step 7
Have a romantic dinner in the hotel's restaurant. Tell the waiter that you are celebrating an anniversary and you may be rewarded with a private booth, complimentary glasses of wine or desserts.
Step 8
Enjoy a couples' massage or spa treatment in the hotel's spa. Let the staff pamper you while you relax in the comforting, loving presence of your partner. Find out what other attractions the hotel has that you and your spouse can enjoy together. Hotels often have dancing, live music or art galleries.
Leaf Group is a USA TODAY content partner providing general travel information. Its content is produced independently of USA TODAY.
Photo Credits
- Jupiterimages/Comstock/Getty Images
- Attribution: Jleon; License: Creative Commons Attribution-Share Alike 3.0 Unported license
- Attribution: Momos; License: Creative Commons Attribution-Share Alike 2.5 Generic, 2.0 Generic and 1.0 Generic license
- Attribution: Fcb981 ; Eric Baetscher (attribution required); License: Creative Commons Attribution-Share Alike 3.0 Unported license
- Attribution: User:Postdlf; License: Creative Commons Attribution-Share Alike 3.0 Unported license
- Attribution: Jean-Christophe BENOIST; License: Creative Commons Attribution 3.0 Unported license


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With more than 1,400 Genesys certification courses and training modules completed by its staff, cloud and premise contact centre, unified communication and collaboration, and business process automation specialists. Elingo is one of the most highly qualified partners on the continent of Genesys, the multinational omnichannel solutions provider.
"For us, it does not matter if you are an engineer, directly involved with a project, are in sales, in administration, provide support, or are in senior management, every person at Elingo must go through the Genesys certification and training modules process. This enables us to give our customers the peace of mind that our superior implementations and support can meet all their requirements," says Karl Reed, Chief Solutions Officer at Elingo.
Furthermore, Reed says the fact that it approaches all engagements with new and current customers from a trusted cx advisory position requires the company to have confidence in its skills.
"To do this, the highest level of product knowledge and all-encompassing solutions are critical. This can only be achieved through rigorous solutions training, best practises, and sound business understanding."
This commitment to investing in its people, is fundamental to the Elingo approach to its business and has been the "Elingo way" for over 21 years.
"Our product is our people. By investing in them, we empower individuals to consult, deliver and support solutions to customers that help address their unique business challenges. Within the first week of a person joining the company, they begin their training process. For us, it is about giving people the skills they need as quickly and effectively as possible," he says.
Reed feels that this commitment to training and certification form the core of the business.
"This focus is something that even applies to people who join us from other Genesys partners. Irrespective of their experience and background, they must have all the courses and certifications in place before dealing with customers."
This enables Elingo to deliver a better and unique customer experience that allows it to differentiate itself in today's ultra-competitive market. Reed says that the company does not want there to be any grey areas when it comes to customers doubting whether the business has the skills in place to help them.
"We are showing customers that by investing in the skills of our employees, we are able to deliver better outcomes for them and they have people working on their account that have the expertise to do so. One of the worst things that can happen for any customer is to appoint a service provider only for the people who arrive on-site not to have the skills in place to work on a project."
Additionally, Elingo employees undergo a rigorous mentorship programme to align their own expectations with the deliverables they need to achieve at the company and for our customers.
"Because of our training principles, it can take anything from six months to a year before a new employee can go to a customer site. We pride ourselves in the skills and expertise of our people to ensure they have the skills in place to take our business and that of our customers to the next level," he concludes.
For more info, please go to: https://www.freedomtointeract.co.za/
About Elingo
Elingo (Pty) Ltd. is a Johannesburg-based ICT company focused on services and solutions within the multimedia contact centre and enterprise IP telephony space.
The technology firm has partnered with established industry leaders to ensure the supply of tailor-made, versatile and customisable solutions that integrate with any process or system.
The company's product offering is designed primarily to automate each process within the call centre including phone calls, SMS, e-mail, fax or web chat.
Elingo's pre-sales teams have unmatched product, technical and architectural knowledge and the quality of its product guarantees value-add and innovation to contact centres of any size.
The company has kept ahead of game-changing trends including the cloud (on-premise and cloud-based Communications as a Service (CaaS), contact centre automation, enterprise IP telephony – as well as consulting, support and education.
Elingo is an industry leader in business process automation and is run by a core team with over 25 years' experience in contact centre design, deployment and support.
Company Contact:
Paul Mc Intyre
CX Executive
Direct Tel & Fax: +27 11 206 2952
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Kay Boyle Correspondence, 1962-1966 | Southern Illinois University Special Collections Research Center
Extent: 1.0 Folders
Scope and Contents: Correspondence, 1962-1966, relating to Pinky, The Cat Who Liked to Sleep and Pinky in Persia by Kay Boyle. Also, included is an unrevised manuscript of Pinky in Persia. 8 ALS, 9 pp.; 2 TLS, 2 pp.; TMs (Xerox), 7 pp. Acc. 3 580.


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New Audi A4, Q7 Models Delayed: Report
Don't expect the next-generation Audi A4 or Q7 models to make an appearance this year, as the German automaker has delayed both vehicles.
According to a report from German publication Focus, the Audi A4 will be delayed until the summer of 2015 while the new Q7 has been delayed again as Audi is not content with the SUV's styling. This is actually the second delay for the Q7 due to its design. Initially, it was delayed when Audi's former chief designer Wolfgang Egger wanted changes. Now, Egger is no longer with Audi and new head of R&D Ulrich Hackenburg along with new chief designer Marc Lichte are working on taking out some of the aggressiveness in the Q7. According to an Audi insider, the aggressive design of the Q7 was originally put in place to cater mainly to Russian tastes.
SEE ALSO: 2013 Audi A4 Review
The new Audi A4 sedan was originally scheduled to launch later this year. The German automaker however, wants to tweak the car's styling and tune its suspension and assistance systems. In addition, Audi hopes to have a plug-in hybrid variant ready to go when the next-generation A4 finally launches.
GALLERY: 2013 Audi A4
[Source: Focus]
Discuss this story at our Audi forum


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EaseUS MobiMover Free for Mac for Download – Mac OS X Software
EaseUS MobiMover Free for Mac is a software that makes it easy to transfer and back up data for iOS devices such as Apple's iPhone or iPad. It allows you to transition when you buy a new device or save data on Mac computers to prevent loss in case of theft, loss or bug.It also has the ability to transfer only certain data from one device to another in order to free up space on one of the two devices or simply for the purpose of sharing them. It also manages the simple removal of the elements since its simplified interface to control from a computer.
EaseUS MobiMover Free for Mac is available here as a free version for Apple Mac computers that use the Mac OS X 10.7 and later operating system. It supports iOS 11 and the latest iPhone 8 or iPhone X devices.


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Who we are
The Irish Pharmacy Union
AIC Glennon
Charlemont House, Charlemont Place, Dublin 2.
Tel: 01 619 1100
Fax: 01 707 5849
Email: firstname.lastname@example.com
Nature of Business: Insurance Brokers & Consultants to IPU Members.
Administrators of Group Insurance Schemes for Pharmacy Premises, Professional Indemnity, Legal Fees, Motor, Home and Personal Accident Insurances.
Michael O'Grady: Manager Client Services
Terry Duffy: Senior Claims Executive
Liz Murchan: Client Services Broker
Lisa Breslin: Client Services Broker
Tommy Begley: Client Services Broker
Frank Glennon Limited, trading as "Glennon", "Glennon Insurances" and "AIC Glennon", is regulated by the Central Bank of Ireland.
Member of Brokers Ireland.
Frank Glennon (Life & Pensions) Ltd.
Charlemont House, Charlemont Place, Dublin 2.
Tel: 01 707 5880
Email: email@example.com
Independent Financial Advisers, specialists in the areas of Pensions, Family & Business Protection and Investments.
Jeff Lord: Director Client Services
Ross Devlin: Senior Financial Advisor
Davin Spollen: Financial Advisor
Conor Murray: Employee Benefits
Michelle Malone: Employee Benefits
Frank Glennon (Life & Pensions) Limited, trading as "Glennon", "Glennon Employee Benefits" and "Glennon Financial Planning", is regulated by the Central Bank of Ireland.


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Nothing beats traveling with family and friends, and that's exactly what the ever fashionable Uy siblings namely Preview's Fashion Editor-at-Large, Liz Uy, Preview's Creative Director, Vince Uy, and their youngest breed, It blogger (and VSA Wardrobe Blogger nominee), Laureen Uy did just the other week when they went to Paris, France.
Truth be told, they're worthy of having their own show ala Keeping Up with the Kardashians―imagine if we could take a peek at their surely awesome over-filled closets! We j'adore their individual styles and how they are able to translate them in the chicest way possible. Mixing different brands, confidently sporting unexpected pairings, and showing their take on Parisian dressing, all while still being well put together and fun, these three are indeed in the world of fashion for a reason.
Not only was the weather scorching, but this trio made it even hotter with their warm-climate and travel-friendly must-haves, without a doubt turning heads everywhere they go. The trip was only ten days long but there were a whole lot of fashion involved. Take a look at their sartorial choices as we take #LesUysÀParis―where the shots look like they came straight out of a magazine―to our gallery.


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Yesterday saw me collecting Calum and Rhonwyn from Edinburgh for a hill walking day trip to the Loch Lomond and the Trossachs National Park so we could climb the Corbett, Beinn Each.
The day began with typically Scottish weather – rain – for our drive north. We parked the car at the bank of Loch Lubnaig and headed into the pine forest towards Glen Ample. We were lucky enough to encounter some wood sorrel, so had a nibble and continued on our way.
After a short walk along forestry track headed for the glen, we branched off to the east and headed up the western slopes of Beinn Each. From 550m upwards we saw an abundance of blaeberry plants starting to flower. In a couple of months' time these will have transformed into tasty berries, ideal for hillside snacking!
At about the same height, the rain got heavier and the clouds closed in, reducing visibility to about 100m or so.
Despite the decline in weather, Calum and Rhonwyn were still in strong spirits and eager to continue to the top of the hill. We soon reached the summit at 813m and after taking a few photos in the mist, the cloud lifted and we were presented with fabulous views over Loch Lubnaig, Ben Vane, Ben Ledi and along the ridge line to Stuc a'Chroin.
Beinn Each Summit
Despite the mixed weather, Calum and Rhonwyn had a great day out (or so they say!) in the Scottish hills and are keen to get into hill walking. They have aspirations for completing some multi-day expeditions this year which we are going to make sure they achieve.
Loch Lubnaig
Thank you both for an excellent day out!
Travel and Coronavirus
Temporary Coronavirus restrictions and travel advice applies until Monday 26th October.
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Share your personal walking route experiences in Scotland, and comment on other peoples' reports.
Warning Please note that hillwalking when there is snow lying requires an ice-axe, crampons and the knowledge, experience and skill to use them correctly. Summer routes may not be viable or appropriate in winter. See winter information on our skills and safety pages for more information.


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We are down here on the North East lawn where things are literally a buzz of activity.
A group of rag tag men and women wearing construction apparel things like hard hats and tool belts. These people seem to be determined to build this structure properly. We searched for the construction names on the trucks that are parked everywhere but it appears there is not a single one company doing the work.This team just appeared out of the blue.


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A Spectacular Failure
For the past several months I have been using this space to talk about the miracles that God has been doing among us, and that we are starting to notice and celebrate as part of our Transformation process. This month, however, I'm not going to highlight a miracle, but rather a spectacular failure. "Oh, come on, Pastor," you may be saying to yourself, "isn't this newsletter supposed to be inspirational? Shouldn't we just focus on the positive?" But part of trying something new, and of trying to figure out who God is calling us to be as a congregation, is failure. In fact, if some of the things that we were doing didn't fail, it would be a sure sign that we aren't risking very much, that we aren't willing to try something really new for the sake of God's mission. We are called to try and fail, and sometimes to fail spectacularly.
The spectacular failure I'm referring to is our experiment with our weekly Thursday night "Club Akaloo" education event for kids from Kindergarten through 8th grade. The vision was there. Our Sunday School superintendent Christine Colestock had an inspired idea for a high-energy, multi age, educational experience—a dream that was to eventually unite our whole community with age-appropriate education for everyone and a spirit of togetherness as we gathered on Thursday nights to learn, fellowship, and worship together. As if by a miracle, the Lutheran Church put out a new education curriculum, called "Akaloo," which was designed for exactly this sort of thing. And so Christine led us in this new direction, blazing a new trail, to see if this was where God was calling us. And our congregation cheered her on, remembering a time when our Sunday School flourished, when Bethlehem resounded with the energy and enthusiasm of young people. And, miraculously, youth education at Bethlehem tripled in size in just a few months, from 5 kids to 15, half of whom weren't otherwise connected to our congregation. And these kids came week after week, and they learned about Jesus, and they experienced the love of God here, and they really enjoyed it.
But after a while, it became more and more work to keep Akaloo going. Christine had hoped that we could all get behind this new thing God was doing among us, that everyone in our congregation could participate in whatever way they could. But despite what seemed like widespread support for work with young people, week after week, Christine was serving alone, with only her pastor there to cheer her on. Like a campfire that refuses to start no matter how much newspaper and matches you throw into it, Akaloo wasn't able to catch Bethlehem on fire, and slowly smoldered out.
I'm going to be honest with you, I was pretty annoyed by this at first. Christine (and I) poured huge amounts of energy into this project and really wanted it to be a gift to our community—to be a rallying point for us to get behind that would reenergize us for mission. With no one willing to roll up their sleeves and get involved, however, leaders become quickly tired, burned out, and discouraged—and when going it alone, no matter how hard we try, all our hard work leads to failure. And even more frustrating was the fact that it seemed as though everyone was behind it. But as I listened carefully to folks as they remembered the days when the Sunday School was thriving, what they remembered, really, wasn't just an impressive Sunday School, but the feeling of what it is like to be connected to God's calling for us. When everyone wants to get on board, and be a part of what God is doing among us and through us—that's what gives us energy for service. Perhaps this "spectacular failure" is an indication that our calling isn't to rebuild the Sunday School we had in the past, isn't to reconstruct our congregation on old blueprints, but to strike out in a new direction. And we wouldn't have caught this new vision in we hadn't tried and failed.
When we tap into what God has in mind for us, things take off and fly as if they had a life of their own (we could say "inspired by the Holy Spirit"). That's one of the ways God show us that we are on the right track. People can't wait to get involved, all sorts of connections start to happen, we become inspired and energized to work our tails off in service to God (think of the miracles of the last several months). But God also offers course corrections. When things become extremely difficult and people serve only out of a sense of duty, or begrudgingly, or find a way to dodge when the sign up sheet comes around—this could very well be an indication that we are off course a bit, and that God has other things in mind for us. A little bit of resistance is expected, but when roadblocks come up at every intersection, we should pay attention. Even if something worked well in the past, even if it works well at a church across town or across the street, no matter how hard we try, no matter how committed we may be, no matter how great an idea might be, if it's not what God is calling us to do, no amount of effort on our part can make it happen. This might sound fatalistic, but it's really good news. Our job is not to create something out of nothing, or to continue to bail out a sinking ship, but to keep asking "Is this what you want from us God?" and giving things a shot. When we hit on what God has in mind for us, we'll know it.
In the Book of Acts, the religious council is debating whether to let the new "Christians" continue in their work, or to try to get rid of them. The religious leaders were threatened by all the "new stuff" these Christians were up to—what would happen to their old traditions? And (more to the point) what would happen to their power? Gamaliel, a respected teacher, responds in Acts 5:38b-39: "If this plan or this undertaking is of human origin, it will fail; but if it is of God, you will not be able to overthrow them—in that case you may even be found fighting against God!" And yet, we shouldn't be so quick to judge what is and isn't of God. The God who raised Jesus from the dead again and again brings new life out of seemingly hopeless situations. Our "spectacular failure," has inspired a whole new ministry. Three Lutheran churches in our cluster have been looking for something to do together, and heard of our Akaloo experiment. We shared with them our vision, and suddenly our entire cluster of churches is involved—with a seven-church weekly Wednesday Akaloo event starting in September that really has something for all ages. (see the flier elsewhere in this newsletter) Our little Bethlehem dream, and spectacular failure, has evolved into an incredible ministry that we never could have done on our own.
Though we "failed" in what we set out to do, we really were just given a bit of a course correction. It's as if God said "Try it on your own, and it won't work. What I have in mind is something that all the churches can do together." And instead of little Bethlehem Lutheran striking out on its own with little support, we are now part of something bigger than ourselves. Though we thought our calling was for a "Bethlehem Only Akaloo," in fact God was using us as yeast for a much larger loaf. Will this multi-church Akaloo ministry take off? God only knows. If this plan or undertaking is of human origin, it will fail. But if it is of God, well, we might just see some more miracles. But we'll only find out it we are willing to roll up our sleeves, get involved, and risk another spectacular failure that just might lead us to wherever God is calling us next. Isn't transformation fun?
Pastor Erik


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This job has now been filled by Bloomfield Tremayne.
- Premier Reputation, Leading Global Design Firm
- Stunning Studio Environment, Contemporary Culture
- Permanent Position, A Rare Career Opportunity
Our client is one of the leading global Architectural and Interiors design firms, setting the bar high within the industry for both their contemporary, highly designed & unique spaces and strong project delivery spanning a wide range of project types.
They pride themselves on their collaborative and open environments where ideas and teamwork enable them to produce exceptional service to their clients. With a network of offices around the globe, the possibilities are endless. Employees gain career-enhancing exposure to leading edge local and international projects. Nurturing the careers of their employees is one of their fundamental values.
They are currently looking to engage a 3D Visualizer to produce high quality, photo realistic material for schematic stages, high-end client presentation and promotional material.
You will be working on the visualisation team to compliment the design process and to add another dimension, allowing Architects and Interior Designers to present high end images to clients. As such, you must be able to blend easily into a team environment and work closely with your colleagues to produce images of exceptional quality.
An in depth knowledge of 3D Studio Max, a brilliant eye for detail and the ability to produce high quality presentational material will be necessary as well as a well rounded knowledge of presentation software including the Adobe Suite, V-Ray and SketchUp.
This position is within a firm with a premier reputation, this is an unmissable opportunity for a Visualizer with a minimum of 4 years experience, to join this design focused firm who are involved across a diverse range of local and international projects.Please Note: Bloomfield Tremayne adhere strictly to the Privacy Act 1989, you can be assured that your information will be kept confidential and not forwarded to a 3rd party without your consent.
Sorry, we are no longer accepting applications for this position. We suggest browsing similar jobs below or searching our latest jobs section.
If you can't find what you're looking for, please contact us as we'd love to discuss your needs.


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By: Zinhle Mngadi
Thirteen of the 23 people killed in the tragic accident in Pinetown last week were laid to rest on Saturday.
Former provincial premier Zweli Mkhize, Durban Mayor James Nxumalo and MEC of Agriculture Meshack Radebe and deputy transport minister Sindisiwe Chikunga attended the funeral to comfort the families of the deceased of the horrific crash.
The deputy minister promised the mourners that government will work together with Transnet to move heavy cargo vehicles from the road on to the railway to prevent such tragic loss of innocent lives on South Africa's roads.
"The government will be working with Transnet to eliminate heavy vehicles loaded with goods from the roads and onto the rail," said Chikunga.
One of the mourners who asked to remain anonymous expressed her gratitude to the support shown to the families.
She said, "We are hurting today since we are laying our loved ones to rest but the support everyone has shown us makes the pain go away. We are very thankful."
Meanwhile, the residents blocked Fields Hill road on Saturday demanding that government ban heavy trucks from using that road. They also said that if government does not listen to their cries, they will intensify the protest and invite NGO's to join in until government reacts to their outcries.
Twenty three people died in the accident on Fields Hill Road in Pinetown when a heavy loaded runway truck plunged into four loaded minibus taxi's and one car last week Thursday at the peak rush hour just before 19:00 pm.
The truck driver, Sanele May (23), was arrested and had his first appearance in court on Monday. He is facing 22 counts of murder for the deaths of those he crashed into on Thursday night. He is due back in court on Wednesday this week.


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.hack R1 Games/YMMV
Jump to navigation Jump to search
- Ensemble Darkhorse: Mistral was extremely popular, so much so that after she quits in Outbreak, she shows up again near the end of Quarantine for the final battle. Skeith, too, is far more popular than any of the other Phases.
- In Mistral's case, part of it was her character, and part of it was that she was one of the previous few magic specialists in the game, with one of the other two being a bit of The Scrappy and the other not joining up until around the end of Mutation.
- Most Annoying Sound: "*boing* Golden Egg! *boing* *squeak*" or any of the other grunty foods.
- That One Boss: Skeith is ridiculously tough, in part due to being the player's first experience fighting a Phase.