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Race #5 Bells Sprint Race
The fifth event for the 2016 Wildwater season is scheduled for Sunday 14th August starting at Bell's Rapid, on Cathedral Avenue, Brigadoon, with good water levels looking likely. No car shuffle is required.
Race details are:
Date: Sunday 14th August 2013
Venue: Bells Rapid
Registration: 7:30am to 8:30am (No registration after these times)
Briefing: 8:45am
Start: 9:30am
Entry Fee: $10 for CWA members and $20 for non members; Juniors $5.
Online Registration
Online registration here and Pay on the day. Be sure to answer if you will be attending the BBQ lunch.
Post Race BBQ
A BBQ will be provided by Peter 'Master Chef' Liddle. Location details will be provided on the day. (5 min drive from Bells)
Meat provided, just bring a chair and your own drinks.
Starting upstream of the main bridge and finishing downstream of Bolland's elbow.
The course comprises of rapids, winding sections of moving water and ti tree obstacles. As with all adventure type sports, we expect that paddlers entering the race are prepared and have the necessary skills to complete the course safely. Therefore, the race will not be suitable for those who have not paddled white water previously.
The race is open to all boats no more than 4.5m, have no rudders or have their rudders tied up. There will be at least two runs each, best time to score.
Sundries Note (Boats not classed wildwater/downriver kayaks)
For those entering in the sundries category, this race is only open to those who are in competition type boats. This is a timed individual event and we expect those entering the race are competent white water paddlers. Sundry results will not be included in the WW season point-score.
Due to the course being held in wildwater conditions, it is necessary for all paddlers to wear helmets and pfd's. It is also recommended for all paddlers to have grab loops on their boats to assist rescue and to have floatation inside their boats to ensure boats do not fill with water in the case of a capsize. All paddlers will require cockpit skirts with appropriate grab loop for ease of escape from a capsized boat.


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A sterling silver Irish ingot style pendant featuring all the symbols of the History of Ireland by Solvar. The History of Ireland is a hand-crafted range of jewelry that portrays the history of Ireland in a series of historical panels evocative of the panels on the Celtic High Crosses which were such a distinctive expression of Irish Christian Art up to medieval times.
Irish Necklace comes in a presentation box with 18 inch chain included. Measures approx. 1.3 inches tall x .4 inch wide.
Made by Solvar Jewelry, Dublin, Ireland and hallmarked at the Assay office in Dublin Castle
What do the symbols mean? Click on one below to find out

subset: commoncrawl


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Special Concepts concerns the creation and realization of exquisite locations (meeting places for young and old). Areas and concepts, where people like to identify themselves with, as well as being meeting places, residences or places of work. In a sense it engrains itself in the emotional and cultural significance of a city.
Creating involves designing, whilst also providing financial, economic and socio-cultural support in making the realization of these projects feasible, landmarks and cultural icons of our time. Projects that inject a city and/or region with vibrant new color and energy which directly contribute to the positive development of the urbanized area.


text: Two of 5 of my S. purpurea ssp. venosa var. burkeii flowers were eaten last night. What could have done it? I am furious!!! Actually it was the 4 inch buds. One is compleatly gone and the other got something plunged into it and withdrawn. What might have done this? Help please so I can insure this does not happen again.


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The term "pledge" is defined in the Civil Code by the ordinance of March 23, 2006 as being "a contract by which a debtor hands over intangible personal property to his creditor to guarantee his debt".
Guarantee a crucial element of your mortgage
An advantageous guarantee for the borrower
In the event of future non-repayment, the borrower can have recourse to an alternative by giving to his bank, as a guarantee , a life insurance contract , a secure investment or anything else of value allowing the bank to finance itself.
It is a guarantee that requires very little cost. However, this is mainly reserved for bank customers, who already have a portfolio of securities sufficient to guarantee all of this credit.
After becoming aware of these various guarantees existing on the market , you will have to make your choice and choose the guarantee which seems the most advantageous in your case. If your situation allows you to benefit from a mutual health insurance fund, do not hesitate to take it. It is the most advantageous guarantee.
For other cases, it is still recommended to take a deposit as a guarantee . This guarantee is more flexible and at lower costs.
How to choose a broker?
Choosing a good real estate broker in Paris is not an easy task. You want to meet the right person, have confidence, feel safe and above all make sure you get the best financing offer on the market . And like all types of trades, there are many real estate brokers in Paris today, so it is not easy to make your choice!
You will therefore try word-of-mouth to find out if by chance, in your entourage, someone would know a good real estate broker. Then you will search the internet and find yourself faced with a multitude of choices. Or for simplicity, you will go to an agency near your home or your workplace.
- The bank will always seek to protect itself in the case of a mortgage with a guarantee
- There are different types of guarantees that you will have to choose according to your borrower profile
- Surety is certainly the most advantageous guarantee


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Ok, this is something I've been debating on making for awhile, because after seeing so many posts in here that we can't help with, and having to turn people away I figured we should make a thread to highlight what to post and not post in this sub forum.
The official email address for the support desk is "firstname.lastname@example.com" if you get an email from any other domain or username that is asking you for information related to your account, it's nothing official so please disregard it.
Those are the most common ones, please think before posting.
I'll be adding some more here as time goes on, I know few people will view this and the needless spam will ultimately keep coming, but if I can convince a few people to stop the pointless threads I'll feel like this is a job well done.
Check this thread out for more common Q&A's.
Remember when in doubt, email support.
|IF YOU WERE BANNED/TAPED/CURSED/ - YOU CANNOT BE HELPED ON THE FORUMS! Sorry to be blunt but that's the way it is. For information regarding your punishment, contact the support desk! Threads asking why you were being punished will be deleted.
Also please refrain from posting personal information such as your IP address, email address or anything here. Players on the forums can't do anything with this data, and it could be putting you at risk. Only trust requests from the support desk for issues related to account security. Remember, the support desk will never ask for your password either.
|Help! I've been hacked!
|Okay, no you probably haven't been hacked. It's up to you to keep your account secure. Please see this response from the support desk regarding being 'hacked'.
Also, contrary to popular belief, hacking does not just happen. Here are some of the most common reasons that an account could end up compromised.
* You got tricked into giving out your password to a player or website that promised free stuff if you did (these are ALWAYS scams, they just log on as you and steal your stuff)
* You share a device with someone and forgot to erase your password when you logged off (they can simply click "enter" and log in as you!) (Beware of little brothers/sisters who just randomly play and use your items!)
* You had an easy password that somebody guessed (Growtopia does lock out people who guess wrong a few times, so it's very rare this happens unless your password is VERY bad)
* You trusted a friend or another player with your password
* Someone watched you type in your password and remembered it
|This user scammed me! Ban him!/ This user is hosting a DROP GAME or illegal casino
|Alright. Honestly this is the most common thread we get around here. If you were involved in a scam, check out these steps on reporting it. Also, please NEVER create threads to target specific users.
UPDATE: With the 'Systems Update', it's now possible to report worlds! Type /report and carefully read the disclaimer. If you feel a world is truly a scam, go ahead and report it!
- Threads that are crated to bully / single out a player for being a scammer will be deleted, as it just leads to drama, which isn't permitted.
The ONLY way to make sure you don't get scammed is to STAY FAR AWAY from scammers. If you find one... LEAVE!
2) Scammers CANNOT force you to stay or force you to drop items or participate. If you get scammed it is because YOU choose to allow it to happen. You can choose to avoid scams by LEAVING!
3) You can /msg a /mod to let them know about a scam, but only message them ONCE. They may be busy dealing with other things, so don't spam them. Just leave the area where the scammer is!
4) If a mod does come to punish the scammer, they will probably also punish all the people participating in the scam. It is against the rules to even be NEAR a drop game, so make sure you LEAVE!!
5) Even if a scammer gets away with a scam right now, they will probably get caught eventually. Don't worry about it. Stay away from them, warn your friends to stay away from them, and you won't be scammed.
6) Posting on the forums about drop games or scams doesn't do anything. We or the moderators cannot punish people for something they didn't see . It's better to just leave the area and play somewhere safe. You may want to watch the following video by Vange: https://www.youtube.com/watch?v=3IJZjpRv6oY
7) Oh... and the most important thing... STAY AWAY FROM SCAMMERS. Use /ignore on any active scammers you see and then STAY FAR AWAY
|I recycled 200 EXTREMELY EXPENSIVE ITEM HERE. pls it was accident give back
|Okay, unfortunately we most likely cannot give you your items back. If you recycled something, sorry to be blunt but it's YOUR PROBLEM. The game gives you ample warning when recycling items.
|I can't reset my password! I never got the email!
|If you have a question regarding your account security, contact support. Also, when reporting this specific issue, be sure to provide the following information:
Sometimes, we have problems with hotmail, msn and outlook deleting our emails. You can avoid this problem by adding our address to the "Approved senders list".
Add email@example.com, firstname.lastname@example.com, and email@example.com, to the safe senders list.
For instructions on how to do this, visit here:
http://www.wikihow.com/Add-Approved-Senders-to-Hotmail (http://www.wikihow.com/Add-Approved-Senders-to-Hotmail)
|Help I saw @MODNAME here abuse his power!!
|You probably didn't. But creating a thread here to shame the moderators that protect you is a bad idea. Email support and they will investigate EVERY report of moderator malpractice. This is NOT an issue for the forums.
Threads harassing or abusing mods will be deleted and infractions will be given.
|There are inappropriate signs/ A player sweared at me!
|Yikes. Excessive swearing and calling names is really bad. Don't do it! See the official response regarding this issue - and remember. We on the forums have no power to punish cussing players.
It's not technically against the rules to use swear words, but we have given you some tools so that you don't have to see them unless you want to. If someone is bothering you you should...
* Turn your swear filter back on!
Everyone seems to disable the swear filter (yes, we CAN tell you've done that) and then get upset that they are seeing naughty words. If you're not going to use the tools we give you, we can't help you, folks!
* Use the /ignore command.
You can use /ignore to make it so specific people can't talk to you. You won't see their PMs or the things they are saying in the chat log or broadcasts by them (I'm actually not 100% certain about the broadcasts... I'll get back to you on it). They WILL see a message that says you are ignoring them, though. This resets each time you log in. To use /ignore type the command followed by the name you wish to ignore. For example:
/ignore Spongebobby
This would make it so I would no longer receive messages from the player named "Spongebobby"
Overall, you have to remember that there are lots of idiots and bullies in the world. When you come across one, it's best to just ignore them, and go find someone worth your time to interact with. The bullies and idiots will either figure out how to act like humans... or they won't. Don't let them make that YOUR problem.
Furthermore, if there are signs in a world harassing you or another player, email the support desk. Something will always be done about this.
|I didn't get my gems that I ordered! Help
|If you ordered gems via the automated IAP (in app purchase) system on iTunes/Android and didn't receive them, go ahead and email the support desk. They'll walk you through getting them any information they need to verify your purchase. However, most times, there shouldn't be any issue with the automated payment system.
If you completed an offer on Tapjoy but didn't receive the gems, you'll have to open a ticket on their website with details about which offer it was/proof of completion.
The official email address for the support desk is "firstname.lastname@example.com" if you get an email from any other domain or username that is asking you for information related to your account, it's nothing official so please disregard it.
Those are the most common ones, please think before posting.
I'll be adding some more here as time goes on, I know few people will view this and the needless spam will ultimately keep coming, but if I can convince a few people to stop the pointless threads I'll feel like this is a job well done.
Check this thread out for more common Q&A's.
Remember when in doubt, email support.


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Collection Agency Letter Found to Say Too Much
(CN) – A debt collection agency's disclosure of a consumer's account number on the face of an envelope is an invasion of privacy, the 3rd Circuit ruled.
In May 2011, Courtney Douglass received a debt collection letter from Convergent Outsourcing about a debt she allegedly owed T-Mobile USA.
Like most business-related mail, the letter was sent in an envelope with a glassine window, but because of the of the size of the window, and the way the letter was placed inside, far more than Douglass's name and address were visible to anyone who saw it, wrote U.S. Circuit Judge Anthony Joseph Scirica.
The window also revealed Convergent's account number for Douglass, and a so-called quick response code, which when scanned by a smart phone, revealed the money Douglass allegedly owed.
Douglass sued in the federal court in Philadelphia, claiming that the disclosure violated the Fair Debt Collection Practices Act (FDCPA).
But U.S. District Judge Joel Slomsky dismissed the case, finding that the account number constituted "benign language."
Benign language neither signals the letter's purpose of debt collection, nor intends to humiliate, or threaten the letter's recipient.
On Friday, the 3rd Circuit reversed that decision, reinstating Douglass's case.
"Convergent's disclosure implicates a core concern animating the FDCPA – the invasion of privacy," Judge Scirica said, writing for the three-judge panel. "The account number is a core piece of information pertaining to Douglass's status as a debtor and Convergent's debt collection effort. Disclosed to the public, it could be used to expose her financial predicament. Because Convergent's disclosure implicates core privacy concerns, it cannot be deemed benign."
Convergent cited cases permitting the presence of "harmless words of symbols" on an envelope, and pointed out that a literal interpretation of the statute would create an absurd result, with even a stamp potentially running foul of the Act.
"Convergent insists that Douglass's account number is a meaningless string of numbers and letters, and its disclosure has not harmed and could not possibly harm Douglass. But the account number is not meaningless – it is a piece of information capable of identifying Douglass as a debtor. And its disclosure has the potential to cause harm to a consumer that the FDCPA was enacted to address," Scirica wrote.


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What Ought to Be The Proper Age To Take Your Child For Swimming?
Swimming just isn't solely an pleasing health exercise however can also be a life-saving ability. Are you anxious to know when to start out swimming classes for child? If sure, then our article is the most effective for you and your doubts. At What Age Can Infants Begin Swimming Classes?Read More →


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Export bar to save £11m Bellotto painting
Culture Minister steps in to prevent painting of Königstein fortress from export
Culture Minister Matt Hancock has placed a temporary export bar on a painting by Bernardo Bellotto to keep it in the country.
The painting of the Fortress of Königstein is at risk of being exported from the UK unless a buyer can be found to match the asking price of £11 million.
A nephew and pupil of the celebrated artist Canaletto, Bellotto's early works are very close in style to those of his master. In 1747 he moved to Dresden at the invitation of King Augustus III of Poland where he developed his own distinctive vision of landscape.
This painting is one of a set of five large-scale views of Königstein, a hill-top fortress near Dresden, commissioned by Augustus III. Bellotto began working in spring 1756 but his pictures were never delivered to Augustus as the artist and his family were forced to flee when war broke out.
All five paintings ended up in Britain, where at least two are recorded from the 1770s.
Culture Minister Matt Hancock said:
This magnificent painting showcases Bellotto's immense skill and technique at one of the most important phases of his career. There is more we can learn about both the artist and the subject from this painting. As one of the finest examples of its kind I hope the funds can be raised so it remains in the UK.
The decision to defer the export licence follows a recommendation by the Reviewing Committee on the Export of Works of Art and Objects of Cultural Interest (RCEWA), administered by The Arts Council.
The RCEWA made its recommendation on the grounds that its departure from the UK would be a misfortune because it was of outstanding aesthetic importance and because of its outstanding significance for the study of Bellotto and the representation of European dynastic strength, military might and enlightened rule.
RCEWA member Aidan Weston-Lewis said:
The large views Bellotto painted in Dresden and the surrounding area are amongst the most original and impressive of all eighteenth-century European landscape paintings. This monumental depiction of the historic fortress of Königstein rising dramatically from the rocky outcrop on which it is built is the most important of his mature works remaining in the UK, and its departure overseas would be very regrettable.
The decision on the export licence application for the painting will be deferred until 17 February 2017. This may be extended until 17 August 2017 if a serious intention to raise funds to purchase it is made at the recommended price of £11,000,000.
Organisations or individuals interested in purchasing the painting should contact the RCEWA on 0845 300 6200.
Images of the painting can be downloaded here.
For media information contact:
Rebecca Evans
Senior Communications Officer
Department for Culture Media and Sport
Tel: 0207 211 6513
Email: email@example.com
Notes to editors
1.Organisations or individuals interested in purchasing the painting should contact the RCEWA on 0845 300 6200.
Details of the painting are as follows: The Fortress of Königstein, from the North Bernardo Bellotto (1722-1780) Oil on canvas, 52 x 93 inches (132 x 236 cm)
The Reviewing Committee on the Export of Works of Art and Objects of Cultural Interest is an independent body, serviced by The Arts Council, advises the Secretary of State for Culture, Media and Sport on whether a cultural object, intended for export, is of national importance under specified criteria.
The Arts Council champions, develops and invests in artistic and cultural experiences that enrich people's lives. It supports a range of activities across the arts, museums and libraries – from theatre to digital art, reading to dance, music to literature, and crafts to collections. www.artscouncil.org.uk


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Though their techniques and pathways are different, both artists are on exploratory journeys
Artists Merrilee Challiss and UAB professor of art Derek Cracco examine spirituality and religion through their featured work in New American Paintings.
Challiss, UAB Alumna and former owner of Bottletree, is back home after spending some time with the Apache. She was on a journey in Truth or Consequences, New Mexico to find her spiritual center.
Challiss is now a full time visual artist, and three of her paintings were recently featured in the South edition of New American Paintings (NAP), a juried exhibition in print, issue #118. Her new hobbies--reading about shamanism, ancient beliefs, and early human civilizations--she says have been informing her work.
Challiss says she's trying to paint energy. She's translating nature into the imaginary, the abstract into the concrete.
"[The pieces in NAP] are directly taken from my experiences working with the shamans," she says. The Apache shamans use herbal medicines to assist people on their journey inward to find guidance.
Along with Challiss, Cracco's paintings also appear in NAP issue #118. While in his printmaking classroom, he described his work as dealing with fields of light and color. His work expresses an appreciation for the ephemeral and modern science, according to Cracco.
"Beauty that just is there and gone in a moment like fireworks," he says. "Like little stars." In his work, astronomy and particle physics combine to create "pointillist-style paintings."
"I feel that a lot of the images that I'm working on now of astronomy and particle physics are actually information that science is gathering that is kind of whittling away at what I see as the high power," he says.
In Etude 3, one of Cracco's submissions to NAP, radiant specks of red and white light seem to stream through a light blue void, like falling stars reflected across a body of water.
"As we gain more knowledge, God keeps getting relegated to our ignorance in these spaces that we don't know," he says. "And the more we know, the less space God has to exist. So, these images are basically proof of that in a beautiful way."
In contrast, Challiss has been embracing what she sees in her "inner world" and expressing it on canvas.
"[My art has] things you can latch onto--an eye, hand or branch--but the rest of it is very subjective," she says. "An interpretation of what I'm seeing in my inner realm."
When Challiss begins working, she uses a mixture of watercolor and acrylic, called wash, to create layers and blobs of color.
"That's like the gestation period for a piece," she says. "It's developing like a fetus would. It's growing features and the layers start having more meaning."
With Cracco's art, he has to understand how colors blend from a distance as he paints pigment by pigment.
"The brush never actually touches the canvas," he says. "The paint is carried by the brush, and it's dripped onto the surface of the canvas. Almost like little castles or little cones that begin to build up. They're rough and bumpy like stingray skin."
As artists, Challiss and Cracco have both struggled to transform their income-sustaining jobs into their ideal careers, but both encourage young artists to do what they love. According to Cracco, everything will fall into place if you do.
"If you make one piece out of ten [attempts] then that's good. That's success," Challiss says, quoting her old UAB art professor John Millan. "I always keep that in the back of my brain."
To learn more about the UAB Department of Art and Art History, see the department's website. To see more of Derek Cracco's and Merrilee Challiss's art, visit their websites at derekcracco.com and merrileechalliss.com.
Kayla McLaughlin is a 2015-2016 UAB Digital Media fellow and an English and Communications student with a concentration in creative writing. She works mostly with writing, photography, and videography.


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I recently attended the Data Integrity Validation conference, Aug. 14-15, in Waltham, Massachusetts, hosted by the Institute of Validation Technology (IVT). Having done a little homework and being able to recite the components of ALCOA (attributable, legible, contemporaneous, original, accurate) without looking, I felt like I had a pretty good understanding of data integrity — cue derisive coughs and snickers. After the first 10 minutes, it became apparent how sorely mistaken I was. Overall, the conference was extremely valuable and featured a lineup of highly knowledgeable presenters. Here are my top five highlights of the conference.
A funny thing about people is they like to purchase products that work. Backtracking through a product's development life cycle, adherence to data integrity best practices is a big part of making products that function as promised. With health care-related products, data integrity is particularly critical because it contributes to product trustworthiness and patient safety.
To that end, the following are some of the key Good Practice (GxP) guidelines surrounding data integrity:
Data integrity regulations are documented in 21 CFR Parts 211 and 212. Noncompliance to any of the regulations, intentional or otherwise, leads to things like Form 483s, warning letters and, of course, headlines:
During a workshop facilitated by Chimnoy Roy, industry consultant, ValGenesis Inc., the concept of data integrity was discussed, dissected and debated in an effort to identify where processes breakdown and incidents occur. A detailed whiteboard exercise revealed some of the root causes of data integrity issues:
Enjoying this article? You may also like this White Paper:
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The facilitator concluded the session by discussing some starting points for improving data integrity processes. Topping the list of action items was establishing a strong culture of quality and compliance with full buy-in and participation from every person in the company. This includes defining clear expectations of all organizational staff, empowering employees to speak up, establishing stricter risk assessment controls, and keeping abreast of regulatory trends and guidelines.
"Of course we trust you, so we don't need to see all your data records," said no regulatory agency, ever. Here are just a few of the less-than-adequate data management practices observed by inspectors that become the stuff warning letters are made of:
A few of the presenters addressed audit trails as a way to identify and fill data integrity gaps. By definition, an audit trail is a secure, computer-generated, time-stamped electronic record of a computerized system's application processes that run within it and a record of the activity of the system users. In simpler, less verbose terms, total transparency in data management is what we're going for.
Audit trails are a good way to avoid running afoul of data integrity compliance. However, a full audit trail review can be time-consuming and costly. One tactic to accelerate the process and make it more economical is implementing a risk-based approach. While this practice streamlines the audit trail, it still works to ensure data integrity compliance. Some of the risk considerations you can focus on include:
With this method you can evaluate and act on issues based on the level of risk: high, medium and low.
Effective implementation of audit trails begins by developing and documenting policies that give clear direction about compliance to current good manufacturing practices (CGMP). These policies are accompanied by employee training, corrective and preventive action (CAPA) and prompt remediation activities.
It didn't really take attending a conference on data integrity to learn that computer system validation (CSV) is not a favorite pastime of life sciences companies. For most manufacturers of health care products, CSV is the very definition of pain point. Nevertheless, it is necessary for complying with another regulatory acronym, computer software assurance (CSA) for manufacturing and quality system software.
In addition to protecting public health, the FDA is also responsible for advancing public health. The agency pursues this objective by helping speed innovations that make medicines and therapies more effective, safer and more affordable. However, this endeavor tends to be difficult when life sciences companies are hesitant to adopt digital technologies.
According to the FDA's Francisco (Cisco) Vicenty, program manager, Case for Quality at FDA's Center for Devices and Radiological Health (CDRH), "The Medtech industry's high focus on meeting regulatory requirements versus adopting best quality practices has the potential to increase risk to patients. This compliance‐centric approach has resulted in quality issues and has hampered innovation in manufacturing and product development practices."(2)
In one session, a panel of quality and technology experts offered attendees an incentive to not hide under the bed when the notion of a technology upgrade comes up. The discussion centered around a new FDA guidance that is intended to resolve the common pain points with CSV.
As a spoiler alert, some of the changes manufacturers can look forward to include:
A few of the approaches to software assurance pulled from the actual guidance include:
Consider the relatively simple and routine task of driving. For many people, this involves an occasional glance at the road while most of their attention is given to a cell phone. Recognizing an increase in unsafe driving habits, automobile manufacturers are developing technology to protect us from ourselves. More cars are rolling off the line equipped with features designed to keep us in our lane and automatically apply the brakes when we're about to hit another car, pedestrian or storefront. The possibilities for human error are systematically being eliminated by artificial intelligence technology.
During her session titled "Cognitive Disruption: Holistic IT Solutions," Karen Ginsbury, consultant with PCI Pharma Services, passionately advocated disruption and digitization. From atop her soapbox, she pointed out some of the reasons why data integrity remains one of the most common inspectional findings:
On the subject of automating out opportunities for human error and the temptation to "massage" data, Ginsbury also advised attendees to make way for blockchain. This technology is a distributed ledger for maintaining a permanent, tamper-proof record of transactional data. By design, blockchain is resistant to the deletion or modification of data, which can be useful for many purposes — namely audit trails. Bottom line, Ginsbury stressed that GxP-compliant automation and digital technologies will eliminate data integrity issues, and we should be using them.
It appears that the FDA is finding it necessary to lead the charge for advancing technology in the life sciences arena. In a document outlining its Software Precertification Program, the agency acknowledged that evaluating the safety and effectiveness of software as a medical device (SaMD) requires a more in-depth review process than what the current regulations prescribe. "The application of FDA's longstanding regulatory framework to software can impede access to new and improved software-based medical products. An agile regulatory paradigm is necessary to accommodate the faster rate of development and potential for innovation in software-based products. It's important for public health to address the distinctive aspects of digital health technology."(3)
Data integrity is clearly a major contributor to developing quality products. However, as I learned early in the conference, ensuring the integrity of enormous amounts of data can be complex and difficult. Fortunately, the development of new technologies and best practices to simplify the processes is ongoing. In summary, here are a few tips for achieving and maintaining compliance with data integrity requirements:


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BTRC did not owe the mobile operator Citycell activities were finally closed. BTRC told reporters at a press conference in the capital on Thursday evening, Minister of State for Telecommunications Tarana Halim.
Tarana Halim said at the press conference, " for not giving due Citycell Wave Telecom has been suspended. "
Thursday afternoon at around 5 pm BTRC Director (Enforcement), Yakub Ali Bhuiyan Citycell Pacific Centre, the headquarters of the State to enter the press conference after the announcement.
The first mobile phone operator Citycell around five hundred million owed to the government. In 1989, the regulator of telecommunications services license from the citycell or Pacific Bangladesh Telecom Limited.
This is not due to be closed in July announced Citycell Bangladesh Telecommunications Regulatory Authority (BTRC). The Commission gives notice sitiselake.
Citycell goes to court after notice of the Appellate Division to continue to pay the price sitiselake gave two months.
BTRC lawyer Khandaker Reza-e-Rakib told reporters that day, until 17 aagastera Citycell 477 crore to the BTRC is owed. Two-thirds of one month from now, they will have to pay one-third in the next one month.
" Moreover, since August 17 every day 18 million and payment of the regulator. The court ordered the payment of daily money immediately, you will not make money if the regulator to take any action. "
At present, the company owns a 37 percent to 95 percent of BNP leader and former Foreign Minister M Morshed Khan-owned Pacific Bangladesh Telecom Limited.
Singapore's SingTel shares a large part of Asia Pacific Investment Limited was sold to.
SingTel owns 45 per cent of the Citycell. Far East Telecom Limited also owns a 17 percent to 51 percent.


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Our collections
All women deserve to feel feminine, fabulous and fantastic in the clothes they wear. Each style and collection are designed to inspire by all women - young and old. We aim to make each item unique by using airy fabrics, intense colours and adding delicate details. In the merge of these components, we seek to add a little sparkle to your wardrobe.


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Hi, up for sale is 1 Autographed Old Man of the Sea card from the M:TG set Arabian Nights. Card is in Fine condition. Better card conditions are given on a'first come, first serve' basis. Check out my other auctions. Please leave feedback upon receiving your order and I'll promptly do the same.
If there are any problems with your order, let me know before leaving feedback. Mishaps happen and can be fixed. M int (M) - Card is as if it came straight from a pack.
No marks, scratches, or whitening on the front, back, or edges. Card has one or two very small nicks on a edge/corner. Card has light whitening on a edge and/or has light play marks on the front and/or back. Card has whitening on 2 or more edges and has some marks and scratches on front and back of card. Card is heavily played with whitening on all edges and scuffing on the front and back.
Card is heavily played with heavy whitening on all edges, scuffing on the front and back, and may also be creased. The item "MTG magic Autographed OLD MAN OF THE SEA Arabian Nights Blue Djinn English" is in sale since Sunday, December 24, 2017. This item is in the category "Toys & Hobbies\Collectible Card Games\Magic\ The Gathering\MTG Individual Cards".The seller is "mtg-4-you" and is located in Etobicoke, Ontario. This item can be shipped worldwide.


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Paul vs Jesus: Who are you following?
A video to guide you from not falling into the pit of false teachings by modern churches and denominations that use Paul's letter even to reject Christ's teachings!
Paul: Salvation is by grace (Eph 2:8)
Jesus: Salvation by keeping God's commandments (Matt 19:16-19; Rev 22:14).
Paul: Where sin abounds, grace abounds more (Rom 5:20)
Jesus: Grace is conditional (Matt 22:1-14), reversible (Matt 18:21-35) and expiring (Luke 13:6-9)
Paul: Grace of God is the gospel (Acts 20:24)
Jesus: Kingdom of God is the gospel (Matt 9:35; Matt 24:14; Mark 1:15)
Paul: Paul being the master builder built his own foundation and called it as Jesus (1Cor 3:10)
Jesus: Christ's teachings are the foundation (Luke 6:46-49)
Paul: We are adopted by God for which we have no part to play to become His son (Eph 1:5)
Jesus: We must be born of God to become His son (John 1:13; John 3:5) and free from sins to dwell in His house (John 8:34-36)
Paul: Faith is imputed for righteousness (Rom 4:11)
Jesus: Faith is not imputed for righteousness but obedience is required (Matt 7:21-23; Luke 6:46)
Paul: We are predestined according to the purpose of Him (Eph 1:5,11)
Jesus: We will be taken away from Christ by the Father for bearing no fruits (John 15:2)
Paul: We can't earn our salvation (Eph 2:8-9)
Jesus: We must be worthy to attain salvation (Luke 20:35-36)
Paul: Paul was appointed as a teacher (2Tim 1:11)
Jesus: Jesus Christ is our only Teacher (Matt 23:10)
Paul: Commandments of God brings death (Rom 7:7-25)
Jesus: Commandments of God brings life (Matt 19:16-19)
Paul: Sin dwells inside him and blames his wrongdoings on his sins (Rom 7:17, Rom 7:19)
Jesus: We need to be sinless (John 8:34-36) and even cut off our body parts (Mattt 18:8-9) and keep our garments undefiled for our names to get not blotted from the book of Life (Rev 3:4-5).
Paul: Christ had abolish the law (Eph 2:15)
Jesus: Christ did not come to abolish but to fulfill the law (Matt 5:17)
Paul: Doctrine of total depravity (Rom. 3:10-12)
Jesus: Doctrine of total righteousness (Matt 18:8-9; John 8:34-36)
Paul: Doctrine of unconditional election (Eph 1:4-8; Rom 9:11,15, 21)
Jesus: Doctrine of cutting off from Christ (John 15:2; Matt 7:21-23)
Paul: Doctrine of irresistible grace (Rom 9:16; John 6:37)
Jesus: Doctrine of conditional grace (Matt 22:1-14), reversible grace (Matt 18:21-35) and expiring grace (Luke 13:6-9)
Paul: Perseverance of the Saints or Eternal Security or Once Saved Always Saved (Phil 1:6)
Jesus: No one can snatch from God's hand (John 10:27) except the Father Himself will take away from Christ for bearing no fruit (John 15:2)
Paul: Progressive sanctification, meaning slowly transforming like Christ every day and it is a life long process (2Cor 3:17-18)
Jesus: Perfect Sanctification, meaning you must be sinless to live in Christ's house and to get your name not blotted from book of life (John 8:34-36; Rev 3:4-5)
Paul: Circumcised is a debtor to keep the whole law (Gal 5:3)
Jesus: Circumcision is not from Moses but the patriarchs (John 7:22)
Paul: Peter, James and John must go to the circumcised and Paul to the uncircumcised (Gal 2:7-9)
Jesus: All the eleven disciples of Jesus including Peter, James and John was commanded to go to all nations (Matt 28:16-20).
Paul: Wide gate and easy way just by calling on Jesus name and believing in Him in heart (Rom 10:9-13)
Jesus: Narrow gate and difficult path by obeying Jesus Christ (Matt 7:13-14)
Link: https://trumpet-call.org/2016/11/15/cheat-sheet-for-pauls-false-teachings/


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Urban Dwellings 1 3/8" Astoria Drapery Sconce
|Revitalize a room with new drapery fabric using the impressive Astoria drapery sconce. The Astoria can be used with the Metro round pole or you can simply place fabric through the holes for a swag effect.
Choose one for your decor in ebony, walnut, urban bronze, or fruitwood.
A more environmentally friendly drapery hardware line featuring kiln dried sustainable woods hand finished with lead-free paints.


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Memorial Day 2014 at the National Memorial Cemetery of the Pacific • Honolulu, Hawaii
Vanita Rae Smith and Alix Bonneyman Prejean have been the faithful presenters of the
AWON wreath on Memorial Day at the ABMC Honolulu Memorial for about ten years.
They say they greatly enjoy the occasion and we are grateful for their enthusiasm.
This year, Vanita's Grand-nephew, Solomon joined them.
Solomon is wearing his patriotic boots standing beside Ernie Pyle's grave.
In Their Memory
Thanks to Punchbowl Stateside Coordinator Susan Chadd for the arrangements,
and for submitting the photos above.


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Original Guy Williams spacesuit from Lost in Space. (CBS-TV,
1965-68) Silver reflective jumpsuit with red piping on cuffs
and shoulders, with Velcro and zipper front closure, together
with a matching pair of silver boots. Worn by Guy Williams as
Prof. John Robinson, this original costume is quite rare! This
costume was worn in season three (1968-69).
UncleOdiesCollectibles.com is owned by Robert Vanderpool. Copyright � Robert Vanderpool. All rights reserved. All other Trademarks and Copyrights are property of their respected owners. Copyright Policy.


text: If you feel we have miscategorized Vip Nail and they shouldn't be in the Estheticians category, please click the "New Category" button below. If Vip Nail is not the business you are looking for, feel free to click on the Personal Care or Estheticians links above to find another merchant to help you. Reviews for Vip Nail can be found by clicking the "Read Merchant Reviews" link to the right. You can add your own review as well! For driving directions to 7230 E Broadway Blvd in Tucson please scroll down and click on the "View Larger Map" link below the map on the right of the screen. Vip Nail is a Estheticians business located at 7230 E Broadway Blvd in Tucson. They can be reached at (520) 885-4183.


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It's no secret that ladies darts takes a back seat in the world of tungsten. A quick browse through a random selection of darts websites, show small ladies sections and in some cases none at all.
Now, don't get me wrong, I don't go out looking for ladies stuff as a habit. When I look at darts, my priority is shape, size and texture of the barrel, after that, everything else is just a bonus. I don't focus on only pink items and I don't think I'm alone in this. Whilst I (as a woman) appreciate darts companies trying to accommodate women in the sport, I don't think it's necessary to make everything pink and say it's just for women.
I've been having a play with a set of 85% Tungsten, 26g Fatal Attractions – "Fatal 3" made by Red Dragon Darts. Now, as I say, I'm not big on dart aesthetics (my own darts are straight barrelled, partially ringed 23's with black stems and black flights – they are pretty non-descript!), but I think I may have just fallen in love with these Fatals.
For a start, most women like a little bit of a story behind everything, but no one likes out and out cheese. RD have balanced the Fatals story perfectly – all you need to know about the dart, mixed with a hint of romance. The provocatively named Fatal Attractions even have a captivating tag-line; "Fatal Attractions: Beautiful yet deadly for your opponent." This kind of marketing can go one way or another. I am happy to report, Red Dragon have got Fatal Attractions spot on.
These darts are not my usual cup of tea – the barrels are wider than I'm used to and I prefer much heavier grip (if you're looking for grip try the Fatal 4's), but that's all just personal preference. I must admit I was impressed with the look and feel of these darts. Regardless of how cool the Red Dragon stems looked, I had to change them for frumpier stems I'm used to. The pink is understated, it isn't over bearing, and with the rest of the dart, black in colour, they looked pretty lethal… Or even Fatal, you might say.
The Fatal 3's fly smooth and make a satisfying crack as they hit sisal. The only thing I had reservations about was the size of the barrels taking up too much room on the board. But by getting your angles right, you can get leave plenty of room in the T20 bed. You can really take advantage of the shape of the barrel by coasting one dart off another, which you wouldn't be able to do so well with a straight dart. There's always a risk with wider barrels that you might knock a dart out of the board. My dart board is on its last turn, but these darts had brilliant grip – I have had no bounce out's or loose darts at all – in fact I struggled to get most out of the board!
Red Dragon Darts make 4 variations of the Fatal Attractions to suit just about everyone and they come with a nice Red Dragon Darts wallet, 2 sets of flights and smart branded aluminium stems. All the Fatals are available from Red Dragon Darts for £18.90 which is a bargain for what you're getting in a dart.
Not just pretty tungsten.


text: Email and drip campaigns can help your business thrive. Imagine a customer receives your email marketing campaign and instantly theyre intrigued to purchase your product or services. A great way to accomplish this feat is to use a personal tone when writing them. This strategy is far more effective than sending emails that read like newsletters or appear to be spam that the recipient may just put in the trash. Take a look at all the ways using a personal tone in your email and drip campaigns will improve your open rate: The tone of your email The tone of your email is important. If you want the reader of the email to act on it, you want to send a message that seems like you are talking to the reader. There is a bit of an art to this method, as there is a fine line between having a personal tone and being unprofessional. Avoid using slang or foul language, but present the information as if you were telling it to a close friend. Avoid using corporate speak and instead use everyday


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You might have seen photos that feature this dramatic effect: one object in color with the rest in black and white. Here are the best apps and tutorials that show you how to recreate this effect.
How to create split-screen videos
You might have used Layout, Instagram's app which allows you to layout multiple photos in an app. Sadly, Layout doesn't support using video in its app. Luckily, there are plenty of apps that allow you to put two videos side by side. It's super easy.
Best apps to create photo and video slideshows with music
Slideshows have been a popular art form for a long time, and with good reason! Creating slideshows is a good way to turn your photos into video content, a much more enjoyable way to share your photos with friends and family. It's easy to make a video with pictures and music using these apps. (more…)
Clone yourself: Apps to put more than one of the same person in one photo
Have you ever seen those photos that feature the same person twice in a picture? That's a result of putting multiple photos together.


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Register an AID for Host Card Emulation (HCE)
#include "nfc/nfc.h"
NFC_API nfc_result_t nfc_hce_register_aid(const uint8_t *aid, size_t aid_len, app_category_type_t category, const char *invoke_target)
BlackBerry 10.3.0
- aid
Pointer to the buffer containing the AID.
- aid_len
Length of the AID.
- category
The purpose of the emulating application. This is used to help the user choose an application when an AID conflict occurs between two or more applications.
- invoke_target
The target ID in a null-terminated string. When an NFC reader selects the registered AID, the NFC system includes this target ID in the invocation message it sends. When registering a wildcard AID, set this parameter to NULL.
Library:libnfc (For the qcc command, use the -l nfc option to link against this library)
An application that wants to perform HCE as defined in ISO-DEP (ISO/IEC 14443-4) can use this function to register an application identifier (AID) according to ISO/IEC 7816-5. When an NFC reader issues a SELECT command with the registered AID, the application is notified through the Invocation Framework using the invoke_target that the application has provided.
An application can register a specific AID or a wildcard AID. When it registers a specific AID, the AID stays registered (that is, the emulation is active) until the application calls nfc_hce_unregister_aid() or until the application is uninstalled from the system. This means that the emulation remains active regardless of whether the application is running (either in the foreground or in the background) or terminated.
An application can register a specific AID only once, but can register more than one AID. The registration of the same AID by more than one application leads to a routing conflict in the system. When the NFC service receives the first SELECT command with the conflicting AID, it prompts the user to resolve the conflict.
An application can register a wildcard AID by setting the parameters aid to NULL and aid_len to 0. A wildcard AID allows the application to receive all ISO 14443-4 commands when it runs in the foreground; however, when it's running in the background or gets terminated, no HCE commands are routed to the application.
An application also needs to register itself as an invocation target in order to be invoked to handle AID routing and transactions. This can be done in the <invoke-target> of the bar-descriptor.xml file.
- NFC_ISO14443_4_COMMAND_EVENT: This event indicates that a command was generated by the target reader. The application must first call nfc_get_target() to retrieve the event target, and then nfc_get_iso14443_4_emulation_command() using the target retrieved to extract the command data from the triggered event.
- NFC_ISO14443_4_EVENT_CODE_EVENT: This event indicates that an ISO 14443-4 related event has occurred. This event is associated with an event code from the target reader. Call nfc_get_notification_value() to extract the event code (of type iso14443_4_event_t).
Feature set 1 doesn't support this function. When called in feature set 1, the function returns NFC_RESULT_UNSUPPORTED_API.
- NFC_RESULT_INVALID_PARAMETER: A parameter is invalid.
- NFC_RESULT_SERVICE_CONNECTION_ERROR: The application is not connected to the NFC system.
- NFC_RESULT_OUT_OF_MEMORY: The system memory available for the NFC system to complete this operation is insufficient.
- NFC_RESULT_OPERATION_REJECTED: One of the following errors has occurred:
- The application already started an HCE.
- The application already registered the same AID.
- The AID is not valid for the specified category.
- NFC_RESULT_UNSUPPORTED_API: This API is not supported in this feature set.
Last modified: 2015-07-24
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Fixed-term postdoctoral positions at MRC Oulu for 2021
Medical Research Center Oulu (MRC Oulu, https://www.oulu.fi/mrc/) is a strategic research organization of the Northern Ostrobothnia Hospital District and the University of Oulu. MRC Oulu offers a multidisciplinary research environment for clinical, translational and health care socioeconomic research, and promotes high level clinical research and internationalization of the research in the field of medical sciences.
Description of the position
Open postdoctoral positions are available in MRC Oulu for 2021. The duration of the fixed-term positions vary between 3-6 months, up to a maximum cumulative total of 2 person years. The starting date will be at the earliest in January 2021. The applications will be evaluated by an external evaluation panel based on the qualifications of the applicant. Selection will be based on the external evaluation and an overall assessment by the governing board of MRC Oulu. The results of the call will be announced at the earliest in December 2020.
Required qualifications and assessment
The successful candidate must hold a PhD degree in the field of Medicine, Dentistry, Biomedicine, Health Sciences or Medical Technology or other related field. Priority will be given to applicants who are members of a MRC Oulu research group. Docents or docent-level applicants and applicants receiving funding from another Focus Institute (i.e. Biocenter Oulu, Infotech, Thule and Eudaimonia) of the University of Oulu will not be considered.
Fluency in both written and spoken English, as well as good communication and teamwork skills are required. Demonstrated experience in writing scientific publications, potential in acquiring supplementary funding and teaching experience will be taken as merits. When assessing the applicant's qualifications, issues to be considered will include scientific publications, supervision experience, activity in the scientific community and familiarity with the research field.
The successful candidate will be employed at the University of Oulu. The salary will be based on level 5 of the demand level chart for university-level teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (maximum of 50 % of the job-specific component).
Application Procedure
Applications, together with all relevant enclosures, must be submitted using the electronic application system by 9 October 2020 at the latest. All applicants will be notified when the selection process is completed.
In the application, it should be clearly indicated whether the applicant is/is not a member of MRC Oulu (include the names of research group and the group leader). The following documents (1-3) must be in pdf format and attached to the application:
1) Curriculum vitae (max 3 pages)
2) List of publications
3) Research plan (max 2 pages)
Research plan must be titled to summarize the main idea of the research, and it must contain the following sections:
a) Aim and objectives
b) Implementation
c) The role of the applicant in the research project
d) Ethical issues
e) Research funding plan (including the number of applied research months and the period of research)
f) Bibliography (not counted towards the length of the research plan)
Verified copies of the applicant's academic degree certificates/diplomas (and copies of certificates/diplomas relating to the applicant's language proficiency, if not indicated in the academic degree certificates/diplomas) must be provided by request in the case of appointment for position.
It is recommended to give your research plan to a colleague to read through and comment. Tips for writing curriculum vitae and a research plan:
More information: MRC Oulu coordinator katja.riipinen(at)oulu.fi


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Shifting doesn't take a full action. Yes, you need to have finished recovering from your last action, but after you shift, you can immediately act to attack or cast a spell. Also, I don't think Stag gets enough respect. Avoiding critical spells and attacks can save you way more health and other nasty effects than a couple points of DR. Doesn't suffer from bear's sluggish attack speed, either. I don't even care about the AoE ability.
Good post, just a couple things to add: Accuracy is also important to interrupt. A graze gets a -25 penalty to interrupt and a crit gets a +25 bonus. I haven't tried this high-level chanter ability, but it describes the bonus as per hit, rather than a lash: http://pillarsofeternity.gamepedia.com/Aefyllath_Ues_Mith_Fyr For whatever it's worth, bows also enjoy better range than guns. I know I get annoyed when I tell my ranged in the back row to initiate and they move up in front. And one last point against bows is that abilities which add bonus damage, like the DoT on Crippli
You'll probably want to verify this, but from what I've seen, Wildstrike belt adds 10% to base damage, not to the lash. Which is nice, because it then gets multiplied by the lash. This makes sense, because then the belt is valuable to all druids, not just ones with wild strike talents. And it's as you say, accuracy is the top issue. Then again, with zero recovery penalty, blazing fast attack speed and grazes that do 20 damage, it's not such a deal breaker. Basically, if you build for it, wild shape is a great way to do heavy per encounter DPS before you start getting per encounter spel
That's what domestication does to you. Let your bipedal buddy shoot your food in the face for you and you laze around all day chewing bones. Next thing you know, it's shampoo, pink bows, and a puppy pedicure.
I'm level 8 on normal, wrapping up Defiance Bay, and Eder takes very little damage with 90+ deflection at this point. For my melee/offtank characters, I feel they need at least 50 deflection or they're going to have a bad time and eat some crits. I guess the rule is: If you're going to melee, you need enough deflection to offset the accuracy of whatever's trying to kill you to eliminate crits. Main tanks need up 50 points more to eliminate hits. Pretty sure you can see the accuracy of the beast that's chewing on you if you hover over the damage in the combat log.
Thanks for the explanation. The dragon I killed last night seemed to bounce equally between the three melee I had flanking him. Now I know the logic behind it, and that there's a blood price to be paid for trying to melee at all and trying to flank in particular. Then I guess it's simply a question of how much a Bashing shield reduces your tank's DPS and slows down the application of cool abilities on the main hand, like Drain and Marking.
Oof, that's a good question. Perhaps the reason Eder isn't holding aggro as well as I'd like is because the Door is slowing his main attack.
Druid. There's just something satisfying about turning into a monster and wrecking people.
What bugs me about that is that you're trading damage reduction from all enemies hitting your tank for reducing the damage of the one target your tank can hit. Maybe I'm wrong and in the hardest encounters it's more important to slow down the Big Bad Boss than to absorb hits from several enemies. I'll admit I'm not far enough in the game to make that evaluation.
The problem is that tanks generally wear heavy armour and a shield, so even with a high interrupt rate, I think you'll find the sluggish attacks of the tank will interrupt less than the high dex dual-wielder next to him who ignored perception. Perhaps even worse than that, since the tank getting wailed on by three people is going to get interrupted himself rather a lot. It's a nice perk, as you say, if you stack Perception for the deflection, but I don't think it's worth investing in Perception to get. Probably better to get Resolve first and cut down the interruptions the tank receives.
This is a little off topic, but I've found Kana makes a better offtank than sniper. He can only get spells off in the biggest fights, and I find his chant debuffs more compelling than his buffs, so I handed him Justice and slapped a suit of plate on him and sent him to the front lines. He does about as much damage, holds up well under the pressure so far, reduces damage to the rest of the front row, and is better positioned to cast spells once he finally charges up.
Just adding another data point. I did some testing, and it looks like a Druid with both Wildstrike talents will face about 50% of DR of the appropriate type.
Personally, I've got no doubts - damage modifiers can only continue to go up as the series progresses, which only helps Dex over Might. It's a certainty to me that at some point - whether it be in the PoE 1 expansion(s) or in PoE 2 - Might will be completely and totally overshadowed by Dex for all auto-attacker builds. Casters obviously still benefit from Might to get more out of each spell. Looks like you've done some good work though - though I haven't checked your formulas over in detail. Looking forward to seeing what you can come up with. If you can produce some good graphs for commun


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The private sector can produce a lot of change in a short period of time. But when it comes to climate change, there simply isn't time to depend solely on the market to drive needed change toward an environmentally sustainable economy. Our desire to balance economic growth with climate protection and to reduce our dependence on carbon-based fuels requires further action not only from the private sector but from policy-makers as well.
This transition to a more sustainable economy has begun. But more can be done to help move us toward the right solutions for the future.
Already, the green economy is booming. Despite slow growth overall, 2007 was a banner year for clean technology, with revenues up 40 percent and global investments in new energy up 60 percent. California represents almost half of all green-tech investment in the United States. Venture capitalists last year invested $1.78 billion in California green technology companies – double the prior year.
In my industry, banks are also embracing environmental business opportunities, ranging from reducing carbon emissions in their operations to creating "green" credit cards and mortgages to help customers reduce their carbon footprints. We're helping municipalities, like the San Jose and Milpitas school districts, switch to renewable energy sources. And, banks are financing everything from solar, wind and hydro power, to giant buoys that capture energy generated by ocean waves.
Some banks are even looking to invest in clean tech companies, not just lend to them. In the same way banks helped finance California's early agriculture and film industries a century ago, we're taking a fresh look at these opportunities to determine how we can play a productive – and profitable – role.
Public policy leaders are also showing the power of effective government action to stimulate the green economy. But our policy partners can do more to help create a market environment in which sustainable energy alternatives are economically competitive.
First, we need a stable regulatory environment with a bias toward clean energy. When innovators and financial backers are confident of government support, risk calculations change and good things happen. Congress should move to renew the alternative energy and efficiency tax credits that expire at the end of this year. Renewable energy industries need help to build enough market scale to compete with hydrocarbons.
Incentives matter. Some banks, for example, have been looking for financially viable ways to help solar companies create a large-scale market for residential solar leasing. The mayor of San Jose and local solar companies have been working on this challenge, and I applaud them for it.
Second, policy leaders need to work across jurisdictions to determine which incentives or regulations are appropriate at the state level and federal levels. We need to strike a balance between the benefits of states acting as laboratories of innovation and the inefficiency that results from a patchwork of regulation across geographies.
Third, Congress must pass cap-and-trade legislation to reduce greenhouse gas emissions. A system that gives companies "emissions credits" they can trade on an open market will create financial incentives to reduce emissions.
It may sound strange to hear a banker calling for government intervention. It's not a position I take lightly. But, landmark laws like the Clean Air and Clean Water acts have been environmental and economic successes. And it's estimated that California's climate change legislation will create nearly 90,000 new jobs statewide by 2020.
There is a strong connection between our willingness to diversify our energy sources and our ability to grow the global economy sustainably. The good news is that we have access to the financial markets, scientific knowledge, technology and human ingenuity needed to succeed. Just as important, all of us – entrepreneurs, bankers and policy leaders – are working together to preserve our planet for future generations.
KENNETH D. LEWIS is chairman and chief executive officer of Bank of America. He wrote this article for the Mercury News.


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Richmond Alexander Lattimore (May 6, 1906 – February 26, 1984) was an American poet and classicist known for his translations of the Greek classics, especially his versions of the Iliad and Odyssey, which are generally considered as among the best English translations available.
Born to David and Margaret Barnes Lattimore in Paotingfu, China, he graduated from Dartmouth College in 1926. His brother Owen Lattimore was a Sinologist who was blacklisted for his association with China during the McCarthy era, but subsequently rehabilitated when none of the charges against him proved to be true. Richmond was a Rhodes Scholar at Christ Church, Oxford, and received his B.A. in 1932, then received a Ph.D. from the University of Illinois in 1934. He joined the Department of Greek at Bryn Mawr College the following year, and married Alice Bockstahler, with whom he later had two sons, Steven and Alexander; Steven also became a classical scholar and professor at UCLA.[1] From 1943 to 1946, Lattimore was absent from his professorial post to serve in the United States Navy, but returned after the war to remain at Bryn Mawr College, with periodic visiting positions at other universities, until his retirement in 1971. He continued to publish poems and translations for the remainder of his life, with two poems appearing in print posthumously.
He translated the Revelation of John in 1962. A 1979 edition by McGraw-Hill Ryerson included the four Gospels. Lattimore completed translating the New Testament, which was published posthumously in 1996 with the title The New Testament.
Shortly before his death, he was baptised as a Roman Catholic, due in part to his work translating the Gospel of St. Luke.[2]
Lattimore was a Fellow of the Academy of American Poets, and a member of Phi Beta Kappa, the National Institute of Arts and Letters, the American Academy of Arts and Sciences, the American Philosophical Society, the American Philological Association, and the Archaeological Institute of America, as well as a Fellow of the American Academy at Rome and an Honorary Student at Christ Church, Oxford.
Lattimore's translation of Aristophanes' The Frogs won the Bollingen Poetry Translation Prize in 1962.
Ivy League, Geisel School of Medicine, Thayer School of Engineering, Tuck School of Business, National Collegiate Athletic Association
University of Oxford, Trinity College, Cambridge, Colleges of the University of Oxford, Evelyn Waugh, Lewis Carroll
Usb, Charles Dickens, Ram, Lan, FBReader
University of Cambridge, United Kingdom, Oxford University Press, Colleges of the University of Oxford, Jesus College, Oxford
Herodotus, Sophocles, United Nations, University of Chicago, Aeschylus
Hector, Odysseus, Muse, Iliad, Troy
Agamemnon, Wikisource, Iphigenia, Electra, Orestes
Homer, Aeolis, Iliad, Romanization of Greek, Thomas Hobbes


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A poem for all the scars tired of not being able to rest in the peace they deserve.
The thought of you still keeps me up at night.
Oftentimes this memory in particular.
You held -no- gripped my scars in your hand, almost angry they were ever there in the first place. Your gaze locked on me, you pulled me close and I've never felt safer. I collapsed my chin onto your shoulder and let my heavy head rest and the salty tears flow. I felt like I could finally allow myself to breathe in your arms.
I still remember what you said in that boat.
Little did I know, you'd later dig up the same knife used to create those scars, the knife I thought we buried together, the knife I once thought I'd never see again, only to use it against me and reopen those very scars you once resented – to cut even deeper.
Right before my eyes my safest place on your shoulder had become the loneliest place of all, unrecognizable. Yet you still had that same gaze as you did the first time, only it garnered a feeling of numbness in me now, instead of the love and comfort I once felt when met with those eyes.
I stil remember what you said in your driveway.
And they say I'll trust again. And they say the scars will heal.


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Mission Viejo HVAC Repair and Maintenance
Call Lewis Air Services for Heating and Air Conditioning Work
In the Southern California heat, a fully-functioning air conditioner is an essential part of your home or business — and, of course, you'll need a well-maintained heating network for those rare chilly days too. Our Mission Viejo HVAC technicians at Lewis Air Services provide maintenance services for your heating and cooling systems. In addition to our promise of the highest quality repair work, you can also expect excellent customer service when you hire us.
Contact Lewis Air Services at (949) 430-7403, or by completing the form on our website!
Orange County's Heating and Cooling Experts
Lewis Air Services offers complete HVAC repair and maintenance solutions for residents in Mission Viejo and surrounding areas. We are prepared to work with heating and cooling systems of any size, and have experience working not only in residential homes, but in restaurants, hotels, schools, fire stations, and other commercial and industrial properties as well.
We Service Mission Viejo Homes & Businesses In The Areas Of:
- Heating & cooling repairs
- Heating & cooling replacements
- Heating & cooling installations
- HVAC equipment maintenance
- Indoor air quality solutions
- Commercial HVAC services
Lewis Air Services was founded in 1989, and we've maintained our standard of excellence ever since. Our full range of HVAC work is coupled with our culture of stellar customer service. We provide free, in-home estimates and financing options so you always know what you're paying for upfront and can do so in a way that works best for you. We also have a referral program and discounts for senior citizens!
Trane Dealer of the Year
In recognition of our outstanding customer service reputation, highly-knowledgeable staff, and expertise in the installation of Trane products, the heating, ventilation, and cooling company has named Lewis Air Services as the Trane Dealer of the Year. We are proud to be honored for the service our customers know and love.
For all of your heating and cooling questions, contact Lewis Air Services today!


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Kurin swords represent some of the best value production Shinken on the global market.
Specialising in high quality tools for Iaido and Tameshigiri, these unique stainless steel blades offer a great budget option which is highly resilient to cutting practice.
Features of these models include:
Tameshigiri Blade - 2.4 Shaku/72.7cm, full profile blades without Hi, suitable for full spirited test cutting practice of appropriate targets.
SUS 420 Stainless Steel - Fully forged stainless steel blades, hardened to 50-52 HRC for test cutting practice. Stainless material is resistant to staining by water marks caused by target cutting.
Tameshigiri Polish - Machined satin style cutting polish designed to maximise cutting angle and minimise micro scratches caused by target materials.
Silver Kanagu - silver fittings in classic Japanese designs bring an additional touch of class to complete the package.
These swords do not include a stand.
Warning - These swords are extremely sharp, Nine Circles does not accept any liabilty for any injury caused through their use. These swords do not include a stand.
These swords are in stock and ready to dispatch pending our final inspection and UK paperwork requirements.
UK CUSTOMERS TAKE NOTE: Additional Documentation Required - Click here for details
Please note we do not have a shop or showroom. Visitors by appointment only.
This site uses cookies to store information on your computer. See our cookie policy for further details on their usage and how to block them.


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Vietnamese music is bouncing back with many products by veteran and young singers after an inactive period due to the impact of the COVID-19 pandemic.
Spectacular scenery, a tranquil valley, magnificent waterfalls, ethnic minority groups and great terrain for mountain climbing can be found in Yên Thịnh Commune, Hữu Lũng District in the northern province of Lạng Sơn.
The annual Bùi Xuân Phái – Love for Hà Nội prizes were announced on Wednesday at the Vietnam News Agency headquarters in Hà Nội.
E-cigarettes and heated tobacco products (HTPs) were not safe for children, adolescents or young people, and these new products targeting young people had in fact created a new generation of addicts, experts warned.
The tournament aims to celebrate the 66th anniversary of the capital's liberation, the 1,010th anniversary of Thăng Long - Hà Nội and the 10th anniversary of the Hà Nội Golf Association's establishment.


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Lucy Lookingbill, Grandmother
Lucy (aka May Lucy) PICKETT b 16 May 1871, Fredonia, KS, married 4 Dec.
1891 Nevada, MO to George W. LOOKINGBILL. Lucy appeared in 1905 census,
City of Girard, Crawford Co. KS with husband and children. DID NOT
appear in 1910 census, only husband (listed as widower) and boys living
together, her daughters were living with Lucy's mother. WHAT HAPPENED TO
LUCY? Did she pass away, moved, or what? Can you PLEASE help me find my
grandmother. Thank you. Will respond.


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When connecting to machines I've had no problems connected to for years, the screen is now just a black box after updating to Windows 10's newest "feature" update (winver 1803).
Confirmed all three machines (this one and the two remote PCs) are using the most up-to-date version of Teamviewer. I updated one of them to Winver 1803, stillsame issue.
Solved! Go to Solution.


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My search for some small chairs for the kitchen table area is finally over! The chairs I had before blocked the view from my kitchen to the family room and vice-versa, their backs were too high and overall they were too big for that small space. I'd seen some pretty, … [Read more...]
Painting Metal Patio Chairs: 5 Easy Steps to an Awesome Makeover
What's worse than a rusted, faded, and drab looking patio chair? Not being able to enjoy your outdoor space because of them!! We all want to be proud of our homes and be able to have friends or family over. Don't let a little paint get in the way of having fun with your … [Read more...]
How to Cut Bar Stools Down to Counter Height Stools
Yes you can make those wood bar stools fit your counter. Here's an easy DIY fix to make bar stools into counter stools (and a quick makeover too!). Bar stools typically sit at 30" high, this is fine and dandy if you have a proper bar where the countertop is elevated higher … [Read more...]
Recovering This End Up Style Kindergarten Chairs
As a parent of two elementary school students, I always ask my kids' teachers if they need anything for their room. Usually the answer is markers, wipes, or snacks. But, my kindergartner's teacher knows about my secret identity after having taught my older son for a year. So, she … [Read more...]
Make Me Beautiful – The Painting Step
Today I'll show you the painting technique I used on the chair I stripped yesterday. Here is a list of suggested materials: Tarp or drop cloth Brush Primer Rubber gloves Sandpaper (Fine & Medium grits) Spray paint (optional handle adapter to prevent hand cramps and … [Read more...]


text: Italy has long been a popular romantic destination for travelers. Whether it's Firenze or Roma, no matter where you go in Italy you'll find reminders of a past that so many writers have considered the foundation of true romance. An Italian man takes amore seriously. He'll shower you with words of love, and in the bedroom he is a superb...Read More ➝


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Update: Tuesday's "Tonight Show Starring Jimmy Fallon" featured a performance by Liam Gallagher.
The artist performed "Come Back To Me" on the episode.
A video of the performance follows.
Photos from the taping, which also included appearances by Daisy Ridley, Jim Belushi and Monica, are also embedded.
Tuesday's edition of "The Tonight Show Starring Jimmy Fallon" features two noteworthy musical artists.
Liam Gallagher, the formal musical guest, delivers the show-closing musical performance.
Monica also makes an appearance during the episode. The R&B artist sits in with The Roots.
Taped earlier Tuesday, the episode additionally features interviews with Daisy Ridley and Jim Belushi. Kate Berlant and John Early meanwhile join host Jimmy Fallon for a "Holiday Gift Ideas" sketch.


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EMCC introduces new outdoor tourism program | News
MILLINOCKET, Maine (NEWS CENTER) -- Eastern Maine Community College in Millinocket is embracing the region's natural beauty with a new program that could bring more people to the area to live and work.
The new Outdoor Recreation and Tourism program is a two-year associate degree program. Students will be trained in guiding and outfitting of outdoor excursions along with management, customer service and hospitality.
The goal is to attract people to the area and promote year round outdoor tourism in the region, as well as attract new residents and business owners.
"We really want to embrace people, our entrepreneurs, folks that may want to operate a business here and create a business. It really is an opportunity to provide something that's home grow, to provide economic development to a region that's very much struggling," said Associate Academic Dean Debbie Rountree.
The program will launch in the fall and Eastern Maine Community College in Millinocket is currently accepting applications for 24 students.


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Whale watching season in Australia is one of the best and most popular times to travel to the east, south or west coast, as the waters are filled with giant playful whales. Every year from around May until November Australian coastlines are inundated with migrating Humpback, Southern Right and Minke Whales as they make their way north to relax in the warmer waters with their young.
There are numerous destinations dotting the coastline of Australia that are hotspots for whale watching, mainly Hervey Bay and the surrounding Fraser Coast region, the Eyre Peninsula in South Australia and Ningaloo Reef/Exmouth, Augusta and Fremantle on the West Australian coasts. Depending on where you are located or are travelling to for the whale watching season, there are various options available to you to see these majestic creatures.
Be it from above or below, whichever way you choose to experience this incredible spectacle, you'll be blown away by the sheer size and inquisitive nature of these giant sea creatures. Here we outline some of the best ways to go whale watching in Australia, where you can do each, and what operators offer these experiences.
Whale Watching… from a boat
One of the most obvious and popular choices is a whale watching cruise. Departing the mainland, you'll be taken just off the coast to settle in a prime position to watch the whales travel up and down the 'Humpback Highway'.
A whale watching cruise will get you as close as possible to the action as the whales breach, tail slap and simply check out the boats on their way either north or south, depending on the time of your visit. The boats aren't allowed to get too close to the whales, but if your cruise is lucky enough to be the subject of a whale's affection, then they'll come right up to the boat and put on a show, giving you front-row seats.
In Queensland, stand out locations for whale watching cruises include the Gold Coast and Sunshine Coast, Hervey Bay, Brisbane (via Moreton Bay), and as far north as the Whitsundays in North Queensland. There are a number of operators conducting daily cruises out onto the water to see these awesome animals, with various different departure times throughout the day.
Some of the top operators include Tangalooma Whale Watching, Brisbane Whale Watching, Whales in Paradise, Sea World Whale Watch, and Whale One in South East Queensland, Tasman Venture, Blue Dolphin Marine Tours, Freedom Whale Watch and Whale Song on the Fraser Coast, and Ocean Dynamics in the Whitsundays.
If you're planning to go whale watching in the southern states, New South Wales offers some viable cruise options around the state. You can go whale watching from the likes of Sydney, Port Stephens, Byron Bay and Jervis Bay to name a few, each with some popular cruise companies operating in each.
Popular operators include Byron Bay Dive Centre, Jervis Bay Wild, Narooma Charters and Moonshadow Cruises operating from various destinations along the coastline, Captain Cook Whale Watching Tours, Oz Whale Watching, Whale Watching Sydney and FantaSea Cruises in the state's capital.
Heading further south, the beautiful state of Victoria doesn't have as much variety as the northern states, but it features operators in two popular destinations; Phillip Island and Lakes Entrance.
You have the likes of Wildlife Coast Cruises and Wild Ocean EcoBoat Adventure Tour operating off Phillip Island and Amaroo Cruises from the beautiful Lakes Entrance on the mainland.
If you travel to the left of the country, Western Australia is one of the top spots for whale watching and the sheer size of the state's coastline means there are ample opportunities to get out on the water to spot migrating whales. Destinations such as Albany, Augusta, Exmouth/Ningaloo Reef, Rottnest Island and Broome, Fremantle and Perth are all hotspots for the whales.
If you're planning to go whale watching along the WA coastline then you'll be heading out with some of these operators. All Sea Charters, Legend Charters, Whale Watching Western Australia and Naturaliste Charters in the Dunsborough and Augusta regions, Absolute Ocean Charters and Broome Whale Whale Watching up north in Broome, Ocean Eco Adventures, Coral Bay Ecotours and Ningaloo Marine Interactions in the Exmouth/Ningaloo Reef region, and Rottnest Express, Rottnest Fast Ferries and Mills Charters and Whale Watching Western Australia in the Fremantle and Perth regions.
Whale Watching… from the water
If a cruise is too tame for you, or you've 'been there done that', then this is the next adventure for you. Swimming with humpback whales is a calming, adventurous, exciting and humbling experience you'll never forget. With both the east and west coasts home to operators offering whale swims, Queenslanders and Western Australians alike will be given the option to jump in head first and come eye-to-eye with these giants.
Mooloolaba on the Sunshine Coast in sunny Queensland is where you'll find local operator Sunreef Mooloolaba. Offering the chance to don a wetsuit, snorkel and mask, the small group of swimmers will jump in and swim with these majestic creatures all while at a safe distance.
An adventure that's boasted about by all who've done it, swimming with humpback whales in the iconic Sunshine Coast region is an experience you'll want to do again and again.
Journeying over to the western side of the country, there are a handful of operators conducting humpback whale swimming day tours from Exmouth. The likes of Exmouth Diving and Whale Shark Centre, Live Ningaloo, Ningaloo Discovery and Three Islands Whale Shark Dive, all offer the chance to swim alongside humpbacks during migration season.
Even though the WA coast and Ningaloo Reef/Exmouth regions are usually renowned for offering visitors the chance to go swimming with whale sharks, swimming with humpbacks is a more exclusive adventure that can only be done for a short period of time every year.
This is a more expensive option for holidaymakers, however, it is well worth the investment, as the photo opportunities present as you swim amongst and alongside whales and their calves are around every stroke. This is the kind of experience that will stick with you for years to come, and if you can put away the fear of getting in the water with these massive animals, it is one you'll never regret.
If you are wishing to stay dry and enjoy the spectacle from the boat then it's best to find a purpose built whale watching vessel with spacious decks to witness the whales in action. With 5 viewing platforms across 3 levels plus underwater cameras and hydrophones to hear the whale song- Whale Watching Western Australia fits the bill. You can join them for a spot of whale watching from two convenient locations at Augusta or Fremantle.
Whale Watching… from the sky
Scenic flights are popular all throughout the year, however, certain operators on the Australian coasts are lucky enough to add whale watching to their scenic flight itinerary. Instead of looking out to the horizon of the beautiful Sydney harbour, you can look down to the waters to try and spot whales swimming up and down the coast.
There are operators taking off on a scenic plane or helicopter flight around the country, but doing so in migration season from Sydney, Gold Coast, Brisbane, Sunshine Coast, Whitsundays, and Perth, means you might have the chance to watch a whale or two breaches, tail slaps or sky hops from above.
Queensland operators include Cloud 9 Seaplanes, V2 Helicopters, Paradise Seaplanes, Air Whitsundays. Western Australia operators include Rotorvation Helicopters, Victoria's operators include Phillip Island Helicopters, and for New South Wales, Sydney Heli Tours.
Whale Watching… from land
As whale watching cruises do tend to fill up quite quickly, especially in peak season, watching the whales from land might be your next best option. Ideal for people who don't enjoy cruising or don't want to pay for whale watching, there are various points along the east and west coasts that offer great land-based viewing options.
All over the country, there are a number of popular lookout points and some lesser known gems that will give you the chance to catch a glimpse of these majestic creatures as they journey close to shore.
If you have binoculars or a camera with some epic zoom, you won't want to leave that at home, because even though they swim relatively close to home, you won't have as great a view as the cruise ships floating within a boat's length from them.
The majority of regions in the area offer some great land-based viewing options including New South Wales' Eden, Byron Bay Lighthouse, Batemans Bay, Ben Boyd National Park in Merimbula, Bar Rock road in Narooma, Redhead Bluff in Newcastle's Awabakal Nature Reserve, and Tomaree Head Summit Walk in Port Stephens.
In the sunshine state, you can journey to Point Danger, North Stradbroke Island, Currumbin or Surfers Paradise on the Gold Coast, various different points on the Sunshine Coast, Fraser Island, Hervey Bay and even the various islands in the Whitsundays.
Image: Rottnest Fast Ferries
The beautiful state of Victoria is blessed with a number of awesome vantage points, helping you save a few dollars. These include the iconic Great Ocean Road, Lakes Entrance, Phillip Island, and Logan's Beach in Warrnambool.
If Western Australia is your go-to destination for whale watching from land, then you won't be disappointed with the likes of Dunsborough Lighthouse, Augusta, Albany, Broome and Exmouth all offering some state-of-the-art views.
Check out all of our whale watching tours and cruises and book your spots early before they sell out!
To go in the running to win double passes for a number of our popular whale watching cruises and experiences, head over to our Facebook page for our daily giveaways starting Thursday, May 4th, 2017.


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As Salaamualaikum and a happy Islamic new year!
Just a quick message of wishful duas and blessings from Us for the new Islamic
month… Muharram Sharif May Allah Almighty bring the new year as a Blessing,
Rehmah, Success, Good health, Prosperity and most importantly Good Imaan
for us…May we learn, appreciate and try to follow what past Muslim Ummah
has done to preserve and spread Islam to reach us as it is today…especially the
event of Karb-balah (which was in this month) where Imam Hussain Radiyallahu
Anhu proved to all Muslims (upto the day of judgement) how much sacrifice we
may need to give of our wealth, family and everything we have to fight
against all odds to preserve Islam so that it is spread correctly to the future
generations. …may Allah give us the ability, capability and strength to
propagate at least what we know; so that we too can follow the Sunnah of the
Prophet ( Sallallahu Alaihi Wasallam ) and Sahabah-e-Ikram (Radiyallahu Anhum )
and all the past Muslim Ummah who have helped to spread Islam to us…Ameen.
May the coming year be a chance for us as an Ummah to unite and be strong
like we were at the Sahabah's time and try to understand that any difficulty or
happiness we get is all from Allah, we should thank Him for the best Blessing
that He has bestowed upon us (even though we are not deserving) which is
that he has made us in the ummah of the Greatest Creation, Greatest Prophet
and Greatest Leader-Prophet Mohamed ( Sallallahu Alaihi Wasallam ) and
whatever happens we should fight against all odds to keep this faith strong not
only for us but to make sure that the future generations of Muslims receive a
decent and pure understanding of Islam through us.
Take care and remember us and all the Muslim Ummah in your duas'.


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$43,000 / 20 Acres / Sold
Square, level 20 +/- acres zoned for up to four homes! Loads of trees, a seasonal creek, and only 1/4 mile from paved, county road. Very short distance to Deer & Loon Lakes, popular for water fowl, fishing, and other water recreation. Many local camp resorts, Dragoon State Park, 5 mi from Colville Nat'l Forest, 45 mins to 49 Deg North Mtn Resort, 15 mins from groceries, post office, gas station, coffee shops & dry goods suppliers in Loon Lake - and within daily commuting distance of Spokane!
Dear Robert, I think you are one of the nicest people on the planet, and for sure the best realtor. Thank you for all your hard work, great advice, patience, and for sticking in there with me. You really went "above and beyond". The world is a better place with people like you in it and I feel really lucky to have crossed paths with you"
~ Jane Fisher
"We appreciated Tim's hard work. We had 2 different real estate companies prior to meeting you, over the time of a couple years they each brought us 1 prospective buyer. You in turn brought us numerous prospective buyers along with several offers, with a final close in under 2 years. We feel that you had a knowledge of where and how to market our business so it was marketed in the right places and to the right people. As you well know when the sale was finalized it was at our asking price with little or no haggling.
We appreciate the fact that you were available 7 days a week, and willing to show the business even on a Sunday with very little notice. Tim Thank you once again.
~ Pat and Jody Schatz
"We were referred to Jason a few years ago. We were looking for our dream rural property, however, competition was high and inventory was low. Jason found us a great starter home until the right property came along. He continued to keep looking for us; one day we received a phone call that he "thinks he found the one." We drove out to that day, and we immediately knew Jason was right ~ This was the dream property we had been waiting for! Jason stayed on top of every detail, and we can't thank him enough for listening to all of our needs and wants and finding the perfect property for our family. His attention to detail, care for his customers, integrity, understanding of the market, and work ethic shined every step of the way!"
~ Ashley Lacer, MAI
Certified General Appraiser


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Mitotic defects in tumor promotion, suppression, and response to chemotherapy
Dr. Beth Weaver
March 1 at 12:20pm in the Fralin Auditorium, Fralin Hall room 102
Hosted by Dr. D. Cimini
Dr. Weaver received a Bachelor of Science degree in Biochemistry from Brown University in Providence, RI and a PhD in Biomedical Sciences from the University of California, San Diego, where she studied mitosis and the mitotic checkpoint. During her postdoctoral training at the Ludwig Institute for Cancer Research in La Jolla, CA, she tested the impact of aneuploidy on tumor initiation. In 2008, she joined the faculty at the University of Wisconsin-Madison. She is currently an Associate Professor in the Departments of Cell and Regenerative Biology and Oncology/McArdle Laboratory for Cancer Research. Research interests in the Weaver laboratory focus on the consequences of chromosome segregation errors during mitosis on tumor initiation, progression, and response to chemotherapy, as well as identifying interphase functions of mitotic proteins that influence their effect on tumors. Additional research interests include the interplay between mitotic errors and radiation therapy in HPV positive tumors. The overall goal of her research program is to leverage fundamental insights into mitosis to improve anti-cancer therapies that impact mitosis.
Aneuploidy, an abnormal chromosome number, is hallmark of human tumors proposed to promote tumor initiation and/or progression. However, aneuploidy can both promote and suppress tumors, depending on the rate of chromosome missegregation/chromosomal instability (CIN); low CIN is weakly tumor promoting, while high CIN causes cell death and tumor suppression. We have shown that the microtubule poison paclitaxel (TaxolTM), the best selling chemotherapy drug in history, does not accumulate in primary breast cancers at sufficient concentrations to cause mitotic arrest. Instead, our results suggest that paclitaxel and other microtubule poisons in clinical use increase the rate of CIN over a maximally tolerated threshold in tumors with a pre-existing rate of low CIN. Causes of the widespread low CIN in human cancer remain unclear. Upregulation of the mitotic checkpoint gene Mad1 causes low CIN, and also results in reduced protein levels of the p53 tumor suppressor by preventing sequestration of MDM2, the E3 ubiquitin ligase that targets p53 for degradation. Upregulation of the mitotic kinase Aurora B also causes low CIN and, remarkably, reduces phosphorylation of Aurora B substrates. Expanding our understanding of mitosis, aneuploidy, and CIN in cancer is likely to result in improved anti-cancer treatment strategies and patient outcomes.
Zasadil et al, Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci Transl Med 2014. PMID: 24670687.
Wan et al, A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration. Curr Biol 2014. PMID: 25447996.
Zasadil et al, High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation. Mol Biol Cell 2016. PMID: 27146113.
Funk et al, Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression. Dev Cell 2016. PMID: 27997823.
This seminar will NOT be livestreamed or recorded.