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MEDI4893 is an investigational immunoglobulin G1(κ) monoclonal antibody that specifically binds to and neutralizes alpha-toxin, a key Staphylococcus aureus virulence factor. A triple-amino-acid substitution, M252Y/S254T/T256E, was engineered into the MEDI4893 Fc region to extend its serum half-life. A phase 1, double-blind, dose escalation study was designed to evaluate the safety, tolerability, pharmacokinetics, anti-alpha-toxin-neutralizing activity, and antidrug antibody (ADA) response of MEDI4893 following a single intravenous infusion in healthy adults 18 to 65 years of age. Thirty-three subjects were randomly assigned to receive MEDI4893 at 225 mg (n = 3), 750 mg (n = 3), 2,250 mg (n = 8), or 5,000 mg (n = 12) or placebo (n = 7) and were followed for 360 days. Adverse events were mild or moderate in severity; none were serious. The MEDI4893 peak serum concentration increased dose proportionally from 77.2 μg/ml (225-mg dose) to 1,784 μg/ml (5,000-mg dose). The area under the concentration-time curve from 0 to 360 days also increased dose proportionally, from 4,840 μg · day/ml (225-mg dose) to 91,493 μg · day/ml (5,000-mg dose), indicating linear pharmacokinetics. MEDI4893's terminal half-life was estimated to be 80 to 112 days, which is approximately 4-fold longer than the half-lives of other human immunoglobulin G antibodies. The alpha-toxin-neutralizing activity in serum correlated highly with the MEDI4893 concentrations in serum. Three adults transiently tested positive for ADA on day 151, but this did not have an impact on MEDI4893 serum concentrations or the MEDI4893 safety profile; no subjects exhibited serum ADA at the study end. These data support the continued development of MEDI4893 for the prevention of S. aureus-mediated pneumonia. (This study has been registered at ClinicalTrials.gov under identifier NCT02296320.)
Staphylococcus aureus is a Gram-positive coccus that causes serious infections of multiple organs, including the skin, soft tissues, respiratory tract, bone, joints, and endovascular system (1). S. aureus is the leading cause of hospital-acquired (nosocomial) pneumonia, including ventilator-associated pneumonia (2), resulting in significant morbidity, health care resource utilization, and death (3). Although antibiotics are the standard of care for S. aureus pneumonia (4, 5), treatment is complicated by increasing rates of antibiotic resistance among clinical isolates. Antibiotic-resistant S. aureus has been associated with increased rates of morbidity and mortality and an increased cost of treatment (6). These challenges warrant consideration of new approaches to the management and prevention of serious S. aureus infection.
An innovative approach to the prevention of S. aureus pneumonia could be the use of an anti-infective monoclonal antibody for immunoprophylaxis that targets a specific common virulence factor protein on S. aureus (7). Recent research has shown the S. aureus alpha-toxin protein (also called alpha-hemolysin) to be a viable target for this type of disease prevention strategy (8–12). Alpha-toxin is a highly conserved, key virulence factor of S. aureus that functions as a cytolytic pore-forming toxin that, when released into the infected host, leads to tissue disruption, programmed cell death of leukocytes and endothelial cells, bacterial dissemination, and immune dysregulation (8, 13–17). Thus, the neutralization of alpha-toxin should prevent the physiological damage caused by the toxin and limit the dissemination of S. aureus. This theory is supported by the observation that hospital isolates of S. aureus possessing a defective alpha-toxin gene have reduced virulence in mouse infection models (18).
MEDI4893 is an investigational human immunoglobulin G1(κ) [IgG1(κ)] monoclonal antibody that binds with a high affinity to and neutralizes S. aureus alpha-toxin, thereby diminishing S. aureus disease pathogenesis, as demonstrated in animal models of lethal pneumonia (8, 19). This monoclonal antibody recognizes a highly conserved region of alpha-toxin that has been identified in >97% of S. aureus clinical isolates sequenced to date around the world (17, 20) and exerts its neutralizing activity through a dual mechanism: (i) it sterically blocks binding of alpha-toxin to the toxin's cellular receptor, and (ii) it prevents alpha-toxin from adopting the pore-forming heptameric transmembrane conformation that is required for host cell lysis (19). MEDI4893 was derived from a previously described anti-alpha-toxin monoclonal antibody, LC10, and possesses a triple-amino-acid substitution (M252Y/S254T/T256E [YTE]) in the antibody Fc region that confers an extended serum half-life by increasing the affinity of antibody binding to the neonatal Fc receptor involved in lysosomal recycling of IgG molecules (21). Importantly, the YTE substitution does not interfere with the specificity of binding of antibody molecules to their target epitopes, as is evident in the ability of MEDI4893 to neutralize alpha-toxin by binding to the epitope involved in cell attachment and lytic pore formation (8, 19, 21).
MEDI4893 is currently under clinical investigation to assess its safety and efficacy in preventing S. aureus pneumonia in hospitalized, S. aureus-colonized patients (ClinicalTrials.gov identifier NCT02296320; EudraCT identifier 2014-001097-34). Described here are the results of the first-in-human dose escalation study designed to evaluate the safety, tolerability, single-dose pharmacokinetics, ex vivo alpha-toxin-neutralizing activity, and antidrug antibody (ADA) responses of MEDI4893 in healthy adult volunteers. The selection of MEDI4893 doses was based on good laboratory practice toxicology and human pharmacokinetic simulations performed in cynomolgus monkeys, observed and predicted efficacy from mouse pharmacology studies, and U.S. Food and Drug Administration guidelines (22). The selected doses were anticipated to deliver a range of MEDI4893 serum concentrations that would reach and maintain a protective therapeutic level above the 90% effective concentration (EC90) of 211 μg/ml over 30 days, which has been established in a mouse model of S. aureus pneumonia (8).
A total of 33 enrolled subjects received MEDI4893 or placebo: 7, 3, 3, 8, and 12 subjects received either placebo or MEDI4893 at 225 mg, 750 mg, 2,250 mg, or 5,000 mg, respectively. In all, 30 subjects were followed through 360 days postdosing (day 361). One subject randomized to placebo was lost to follow-up (day 160), and two subjects randomized to 5,000 mg of MEDI4893 withdrew consent (on days 76 and 226, respectively) for reasons other than adverse events. Demographic data were fairly balanced across all cohorts (Table 1).
One or more adverse events were reported in 11 of the 26 subjects (42.3%) who received MEDI4893 and 4 of the 7 subjects (57.1%) who received placebo (Table 2). All adverse events were mild or moderate in severity. Four subjects had adverse events that were considered to be related to the study drug, as determined by the principal investigator. These adverse events included (i) headache that lasted for 1 to 2 days and that was reported to be mild in severity in two subjects (one receiving 225 mg of MEDI4893 and the other receiving 2,250 mg of MEDI4893), (ii) urticaria that lasted for 4 days and that was moderate in severity in one subject who received 2,250 mg MEDI4893, and (iii) rash that was mild in severity and that lasted for 2 days in one subject who received 5,000 mg of MEDI4893. There were no serious adverse events, deaths, or study drug discontinuations attributed to adverse events through the end of the study.
MEDI4893 exhibited linear pharmacokinetics with low intersubject variability (Fig. 1). Serum exposure of MEDI4893 increased approximately dose proportionally; the maximum concentration of drug in serum (Cmax) increased from 77 μg/ml at 225 mg to 1,784 μg/ml at 5,000 mg (Table 3). The mean serum area under the concentration-time curve (AUC) from 0 to 360 days postdosing (AUC0–360) increased from 4,840 μg · day/ml at 225 mg to 91,496 μg · day/ml at 5,000 mg. The clearance of MEDI4893 from serum ranged from 42 ml/day to 50 ml/day, which is about 4-fold lower than that of humanized, chimeric, or human IgG1 monoclonal antibodies (23). The terminal half-life of MEDI4893 was estimated to be 80 to 112 days. MEDI4893 serum levels were greater than the therapeutic target concentration of 211 μg/ml (informed by the EC90 in the mouse pneumonia model) for at least 60 days in the 2,250-mg-dose group and at least 120 days in the 5,000-mg-dose group (Fig. 1), thereby exceeding the anticipated protective level of MEDI4893 over those extended time periods postinfusion. The volume of distribution of MEDI4893 at steady state ranged from 4.9 liters to 6.6 liters, indicating a limited distribution to the extravascular space (Table 3).
Measurable levels of MEDI4893 were also detected in nasal wash samples at all dose levels, but the intersubject and intrasubject variabilities over time were high. The mean MEDI4893 Cmax in nasal wash samples increased with dose from 39 ng/ml at 225 mg to 538 ng/ml at 5,000 mg, and the mean AUC from time zero to 30 days postdosing (AUC0–30) in nasal wash samples increased from 288.3 ng · day/ml at 225 mg to 6,314.3 ng · day/ml at 5,000 mg (Table 4). Similarly, the mean AUC from time zero to the time of the last quantifiable concentration (AUClast) of MEDI4893 in nasal wash samples also increased with dose from 287.5 ng · day/ml at 225 mg to 20,407.6 ng · day/ml at 5,000 mg. MEDI4893 was detected in nasal wash samples up to day 31 postinfusion in 2 of 3 subjects in the 225-mg dose cohort; up to day 121 postinfusion in the majority (≥67%) of subjects in the 750-mg, 2,250-mg, and 5,000-mg dose cohorts; and up to day 151 in 10 of 12 (83%) subjects in the 5,000-mg dose cohort (data not shown).
Individual baseline serum concentrations of anti-alpha-toxin-neutralizing antibody in the study participants were low, ranging from 0.1 IU/ml to 3.6 IU/ml, and the median concentration was 0.52 IU/ml (Fig. 2A). The serum concentrations of anti-alpha-toxin-neutralizing antibody increased in a dose-dependent manner after MEDI4893 dosing and were highly correlated with the serum concentrations of MEDI4893 across the cohorts at all time points (Fig. 2B). The median levels of serum anti-alpha-toxin-neutralizing antibody at the end of MEDI4893 infusion (day 1) were 7-, 36-, 247-, and 238-fold greater than the median preinfusion baseline levels in the 225-, 750-, 2,250-, and 5,000-mg, dose cohorts, respectively. The serum levels of anti-alpha-toxin-neutralizing antibody were sustained through 30 days postinfusion (day 31) and were 3-, 15-, 91-, and 92-fold higher than the median preinfusion baseline levels in the 225-, 750-, 2,250-, and 5,000-mg dose cohorts, respectively. The serum levels of anti-alpha-toxin-neutralizing antibody in the 750-, 2,250-, and 5,000-mg dose cohorts at day 31 were >3.2 IU/ml, a concentration that has been found to be associated with favorable clinical outcomes in epidemiology studies (20, 24). These data confirm the ex vivo alpha-toxin-neutralizing activity of MEDI4893 and show that high levels can be maintained through 30 days after intravenous (i.v.) administration.
Four subjects tested positive for MEDI4893 ADA. One subject who received 2,250 mg of MEDI4893 tested positive at the baseline, before administration of the study drug; two subjects, one who received 2,250 mg and one who received 5,000 mg, tested positive both at the baseline and on day 151; and one subject who received 5,000 mg tested positive on day 151 only. All four subjects had a low ADA titer (≤1:30), and none of the subjects tested positive for ADA at the end of the study. The transient presence of ADA was not associated with any adverse events or any impact on MEDI4893 pharmacokinetics.
The MEDI4893 molecule is being developed to provide S. aureus disease prevention for mechanically ventilated patients who are at risk for nosocomial pneumonia. Data from preclinical studies suggest that MEDI4893 would provide effective immunoprophylaxis against S. aureus nosocomial pneumonia.
In this phase 1, first-in-human, dose escalation, placebo-controlled trial, administration of MEDI4893 was not associated with any serious adverse events, deaths, or study discontinuations throughout the study period. Only four adverse events (two cases of headaches, one case of urticaria, and one case of rash) were deemed to be potentially related to the study drug and were transient and mild in severity, supporting the overall acceptable safety profile of MEDI4893.
MEDI4893 exhibited linear pharmacokinetics, showing an extended half-life in healthy adults. The observed MEDI4893 half-life of 80 to 112 days is approximately 4-fold longer than that of other human IgG1 monoclonal antibodies, confirming the antibody half-life extension in humans conferred by the YTE substitution (25–28). The pharmacokinetic profiles of MEDI4893 are similar to those of another antibody engineered to have the YTE substitution, motavizumab-YTE, an anti-respiratory syncytial virus IgG1 monoclonal antibody. Motavizumab-YTE showed an extended half-life of 70 to 100 days in healthy adults, which is also approximately 4-fold longer than that of wild-type motavizumab (29). In addition, the extension of the half-life of MEDI4893 by YTE engineering in humans is consistent with that observed in cynomolgus monkeys, in which the terminal half-life of MEDI4893 was estimated to be approximately 2- to 4-fold longer than that of regular IgG1 antibodies (30). The consistency of the pharmacokinetics across the two species suggests that, like regular IgG1 antibodies, the pharmacokinetics of the MEDI4893 antibody with YTE in cynomolgus monkeys can be predictive of those in humans.
Following a single i.v. infusion, MEDI4893 was distributed to the upper respiratory tract, which is relevant, given the intended target disease of S. aureus nosocomial pneumonia. Despite the high individual and intergroup variability in the levels of MEDI4893 in nasal wash samples, the data presented here demonstrated trends for dose-dependent increases and time-dependent decreases in MEDI4893 levels in nasal wash samples, consistent with the pharmacokinetics in serum. An ongoing phase 2 trial (ClinicalTrials.gov identifier NCT02296320) is currently evaluating the distribution of MEDI4893 into the upper airway and its safety and efficacy as immunoprophylaxis against nosocomial pneumonia in mechanically ventilated patients colonized with S. aureus.
At present, limited data on the immunogenicity of monoclonal antibodies with the YTE substitution are available. A pharmacokinetic and safety study of the anti-respiratory syncytial virus monoclonal antibody motavizumab-YTE demonstrated comparable incidences of detectable ADA responses in healthy subjects receiving single i.v. infusions of motavizumab-YTE (4 of 16 subjects; 25%) and in subjects receiving the nonsubstituted antibody (3 of 15 subjects; 20%) (29). In that study, the presence of ADA did not affect the pharmacokinetics of motavizumab-YTE but did increase the clearance of nonsubstituted motavizumab in two of three ADA-positive subjects (29). In the current study, both the frequency of occurrence and the level of serum ADA were low and transient; three of four subjects who received MEDI4893 had low titers of ADA at the baseline, and none of the subjects tested positive for ADA at the end of the study. Transient serum ADA responses were not associated with any impact on MEDI4893 safety or serum pharmacokinetics.
The ex vivo anti-alpha-toxin-neutralizing antibody assay utilized in this study provides a sensitive and specific measure of MEDI4893's capacity to effectively neutralize alpha-toxin as a surrogate indicator of the antibody's potential efficacy in vivo. This assay has also previously been used to map the epitope on alpha-toxin recognized by MEDI4893, identified to be the portion of the alpha-toxin rim domain involved in host cell attachment (19).
In this study, the ex vivo alpha-toxin-neutralizing activity of MEDI4893 in serum increased substantially (75- to 238-fold) after MEDI4893 dosing and showed a high correlation with MEDI4893 exposure across all dose levels, indicating the intact functionality of MEDI4893 in humans. In addition, the alpha-toxin-neutralizing capacity of MEDI4893 was maintained through 30 days postdosing, during which the concentration remained above 3.2 IU/ml, a threshold that has been shown in a previous epidemiology study to correlate with a reduced incidence of S. aureus infections. These results confirm that the YTE amino acid substitution does not diminish the binding or alpha-toxin-neutralizing characteristics of MEDI4893, while it extends its serum pharmacokinetic profile.
Overall, the safety, pharmacokinetic, ADA, and pharmacodynamic data from this first-in-human study of MEDI4893 support the development of MEDI4983 to provide sustained passive immunity against S. aureus disease.
Study objectives and design.This first-in-human, double-blind, randomized, placebo-controlled, dose escalation, phase 1 study was conducted at a single study center in the United States. The primary objective of the study was to evaluate the safety and tolerability of a single i.v. dose of MEDI4893 administered to healthy adults. The secondary objectives were to evaluate the pharmacokinetics of MEDI4893 and to measure ADA levels in serum. Exploratory objectives included measurement of MEDI4893 levels in the upper respiratory tracts of subjects and anti-alpha-toxin-neutralizing antibody concentrations in serum and the upper respiratory tract before and after administration of MEDI4893.
Subjects were randomized to one of four fixed-dose cohorts as follows: a 3:1 ratio of subjects receiving MEDI4893 to subjects receiving placebo in cohorts 1 (225 mg) and 2 (750 mg) and a 4:1 ratio of subjects receiving MEDI4893 to subjects receiving placebo in cohorts 3 (2,250 mg) and 4 (5,000 mg). To review safety parameters and accommodate dose escalation decisions, dosing was staggered such that the first two subjects in cohort 1 were randomized to MEDI4893 or placebo, dosed at least 48 h apart, and followed for 7 days postdosing before the remaining two subjects in cohort 1 were dosed (the remaining two subjects were also dosed at least 48 h apart). If no safety concerns were observed in these four subjects, additional subjects were enrolled in the cohort receiving the next-higher dose. Randomization to subsequent dose levels continued once the 7-day observation period after administration of the previous dose had elapsed.
The study duration included a screening period of up to 28 days and a 360-day pharmacokinetic and safety evaluation follow-up period. Subject visits were every 2 days for the first week (days 2, 4, 6, and 8) and then every week until day 31 (days 15, 22, and 31), every month for the following 4 months (days 61, 91, 121, and 151), and every 2 months until the study end (days 211, 271, and 361).
Inclusion and exclusion criteria of subjects.Healthy adult volunteers 18 to 65 years of age were eligible to participate in the study. Subjects had to be healthy on the basis of their medical history and physical examination at screening and had to weigh 45 to 110 kg. Subjects also had to have a systolic blood pressure of <140 mm Hg, a diastolic blood pressure of <90 mm Hg, and a normal electrocardiogram at screening. Subjects who had previously received monoclonal antibodies were excluded, as were those who had received immunoglobulin or blood products within the 6 months before study entry or any investigational drug or investigational vaccine within the 120 days before dosing with the study drug.
Written informed consent was obtained from subjects before study procedures began. The Institutional Review Board (Aspire IRB, Santee, CA, USA) approved the study protocol and informed consent documents. The study was conducted in accordance with the ethical principles of the Declaration of Helsinki and the International Council for Harmonization guidelines on good clinical practice.
Assessments.Enrolled subjects were admitted to a phase 1 study unit for pre- and postdosing observation. Vital signs were assessed predosing; every 30 min during study drug infusion; at the completion of the infusion; and at 30 min, 60 min, and 2, 6, 8, and 24 h after the completion of study drug infusion.
Safety assessments included recording of adverse events that occurred during the period immediately after study drug dosing through 90 days postdosing, as well as reporting of serious adverse events, new-onset chronic diseases, and adverse events of special interest (hepatic function abnormality; anaphylaxis, hypersensitivity, and infusion reactions; immune complex disease) that occurred through 360 days postdosing.
Serum samples were collected at the baseline (predose on day 1) and at 1 h and 8 h postdosing on day 1 and during study visits on days 2, 4, 6, 8, 15, 22, 31, 61, 91, 121, 151, 211, 271, and 361 postdosing to evaluate the systemic pharmacokinetic profile of MEDI4893 and the levels of anti-alpha-toxin-neutralizing antibody. Nasal wash samples were also collected at the same times that serum samples were collected (except on day 6) for analysis of the pharmacokinetics of MEDI4893 in the upper respiratory tract. MEDI4893 ADA levels in serum samples collected at the baseline and on days 15, 31, 91, 151, 211, 271, and 361 were measured.
Pharmacokinetic analysis of MEDI4893.The levels of MEDI4893 in both serum and nasal wash samples were measured using a validated enzyme-linked immunosorbent assay. Briefly, an immobilized anti-YTE monoclonal antibody was used to capture MEDI4893 in human serum samples and nasal washes, and a second biotinylated anti-MEDI4893 monoclonal antibody was used for MEDI4893 detection. The MEDI4893 concentration was estimated by interpolating the observed value from a 1/y2-weighted, four-parameter logistic function, standard curve fit that was generated using SoftMax Pro software (v5.2; Molecular Devices Corporation, Sunnyvale, CA). The lower and upper limits of quantitation were 0.23 μg/ml and 15 μg/ml, respectively, for serum samples and 3.5 ng/ml and 100 ng/ml, respectively, for nasal wash samples.
Noncompartmental pharmacokinetic analysis was performed using Phoenix WinNonlin software (Pharsight, CA). The peak (maximum) concentration in serum (Cmax) of MEDI4893 was defined as the observed individual maximum concentration after dosing. The terminal elimination half-life was determined using a log-linear regression of the concentration data with the equation ln(2)/λz, where λz is the slope of the terminal portion of the natural log concentration-time curve, determined by linear regression of the data from at least the last three time points. The systemic exposure was determined by calculating the area under the serum concentration-time curve (AUC) from 0 to 360 days postdosing (AUC0–360), using a linear-log trapezoidal method. The serum AUC of MEDI4893 from time zero to infinity (AUC0–∞) was calculated as AUClast + Clast/λz, where AUClast is the area under the serum concentration-time curve from time zero to the time of the last quantifiable concentration and Clast is the last quantifiable concentration in serum.
Anti-alpha-toxin-neutralizing antibodies.Serum anti-alpha-toxin-neutralizing antibody levels were measured with a red blood cell-based neutralization assay, utilizing the National Institute for Biological Standards and Control's World Health Organization international reference standard (31). The lower limit of quantitation was 0.0007 international unit (IU) per ml, and anti-alpha-toxin-neutralizing antibody levels were reported in international units per milliliter, as described previously (20).
Anti-MEDI4893 antibodies.A validated electrochemiluminescent, solution-phase, bridging immunoassay was used for the detection, confirmation, and titration of anti-MEDI4893 antibodies (ADA) in human serum. Briefly, a mixture of biotinylated and ruthenylated MEDI4893 was used to capture the ADA present in serum samples. The ADA-bridged immune complexes were then bound to a streptavidin-coated mesoscale discovery plate. Samples with electrochemiluminescent responses equal to or above the cutoff point value (1.37 times the mean response for six to eight wells of the negative control in each plate) were considered positive. Positive detection of anti-MEDI4893 antibodies was defined as a titer of ≥1:30.
Medical writing and editorial assistance were provided by Yeshi Mikyas and Jeffery Brubaker of MedImmune LLC, Gaithersburg, MD, USA.
All of us were involved in one or more aspects of the following: the conception or design of the study or the acquisition, analysis, or interpretation of the data. All of us were equally involved in the writing of the manuscript.
This study was sponsored by MedImmune LLC, Gaithersburg, MD, an affiliate of AstraZeneca.
MedImmune was involved in the study design, data collection and interpretation, and the decision to submit the work for publication.
- Received 13 May 2016.
- Returned for modification 11 June 2016.
- Accepted 3 September 2016.
- Accepted manuscript posted online 17 October 2016.
- Copyright © 2016 Yu et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license .


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Mushroom-headed Rock Band drum pads comes yet another mod that oozes awesomeness. The Rock Band Stompbox tackles an issue any digital rocker has faced -- accidental (and often unwanted) activation of Overdrive / Star Power. Put simply, this engineering fellow ripped his axe apart, ganked a spare effects pedal and put his superb wiring skills to good use. Hit up the read link for a pictorial step-by-step, or jump on past the break for a video demonstration.
[Thanks, Brad]

subset: commoncrawl


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It's spring time now in Melbourne, and I'm dying to be there!!!
Spring is like the perfect season.
…It means amazing weather, flowers are blooming, people are out and about in summer dresses and on the beach, and other awesome things. ♥
Sam knows how much I like flowers and taking pictures of them, so this afternoon he went around his neighbourhood taking pictures of all his neighbours flowers in their lawns and gardens for me to look at, hehe!
I decided to have some fun playing around with the images, and since I always get tons of questions from people asking me how I edit my images, I thought of doing this post to share some pretty images and also this would show you guys the difference for my photos Before and After post-processing.
Heaps of time and effort go into making the pics on my blog pretty, but I really don't know how to explain how clearly how I edit them, it's not like I do every single one of them the same way.
They're all different! So I guess you'll have just to spot the differences yourself.
I like super contrasty and colorful pictures.. composition and lighting is also very important to me.
All these were taken by Sam, with Sam's brother's random compact digital camera.
For a compact cam I think the shots came out pretty decent! Very sharp images.. for the ones that Sam managed to focus properly, at least!
Ok, so put your cursor over the edited images and you'll see the original picture!
(got this idea from Wendy)
I know they look more "normal" in their original state (it has its own kind of beauty.. the raw, realistic kind!), but I like my flower shots to be over-the-top and dramatic. I always imagine flowers in a whimsical fairyland, like Alice in Wonderland! I'm sure her flowers aren't normal.
I'm reaalllyyy feeling like shooting recently, haven't used my DSLR in awhile..
That's all for today!!!!


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Riverside Centre's Young at Heart class on show
The Young at Heart class at Morpeth Riverside Centre is aimed at older people, but open to all. Every Mon/Weds 10.30-11.30. Have a look at Active Northumberland's photos to see just how much fun it can be.
Or see their timetable of other activities across the county.
See more on sport and activity in the Golden Guide


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Available Homes
Available Floor Plans
We have the ability to provide a number of different floor plans to meet a variety of space and design requirements. Hoover Custom Homes has worked with a number of clients to create custom home plans or build from an existing floor plan like the example included below.
The Castle Rock Floor Plan
The Colthorpe Floor Plan


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Business & Finance Companies
By heavily discounted pupil prices, Highway & Smith's Sports Group, School & University Program gives college school college students the possibility to develop a broader understanding of the sports activities activities business by learning every Sports actions Enterprise Journal and Sports activities Business Each day. Look proper here for ideas for starting a business and for together with new companies and merchandise to an current enterprise. Save time and cash with our offered PSD to wordpress service. Their expertise is strengthened by shut links with organisations by way of consultancy initiatives, instructing on govt enchancment programmes and sponsored analysis. As the Fund Administration Analyst, you'll play an integral perform in LACI's newly launched fairness and debt funding initiatives designed to help the growth of early stage cleantech startups in our incubator packages.
Reasonably, my sense is that privateness considerations, changes in people's social media preferences and behaviours, and broader fatigue … Read More


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The Columbia Esterel Compiler
|The Columbia Esterel Compiler is an open-source compiler designed for research in both hardware and software generation from the Esterel synchronous language.
|It currently supports a subset of so-called Esterel V5, and can generate a C program or a Verilog or BLIF circuit description from an Esterel program.
|It is implemented in C++ using the ANTLR parser generator (version 2.7.2) and the expat XML parsing library (version 1.95). It makes heavy use of modern C++ features such as namespaces, templates, and the standard library. Building it requires gcc 3 or above. As of the 0.3 release, ANTLR is not necessary to compile the system from source.
|Its design is modular. Each pass is a standalone executable invoked by the cec script. The passes communicate through XML files generated from internal data structures by the IR package.
|Mailing list
|The cec-users mailing list
|A Github repository that might be more up-to-date
|cec-0.4.tar.gz: compressed source, documentation, and test cases
|cec-0.4-1.i386.rpm: RPM for Fedora Core 4 and later
|cec-0.4-1.ppc.rpm: RPM for Fedora Core 4 and later
|cec-0.3-1.src.rpm: source RPM
|cec-0.3.tar.gz: compressed source, documentation, and test cases
|cec-0.3-1.i386.rpm: RPM for Red Hat Linux
|cec-0.3-1.src.rpm: source RPM for Red Hat Linux
|cec-0.2.tar.gz: compressed source, documentation, and test cases
|cec-0.2-1.i386.rpm: RPM for Red Hat Linux
|cec-0.2-1.src.rpm: source RPM for Red Hat Linux
|cec-0.1.tar.gz: a very, very old release
|manpage for cec, the user-level command
|IR: the XML-based file storage format
|AST: the intermediate representation
|EsterelPrinter: Esterel prettyprinter
|ExpandModules: the run statement expander
|Dismantle: the AST dismantler
|ASTGRC: the GRC format synthesizer
|GRCOpt: the GRC format optimizer
|GRCPrinter: GRC-to-dot printing for debugging
|GRCsim: GRC simulator for debugging
|BLIF: circuit netlist format utilities
|GRCC2: the C generator
|CPrinter: C generation helper routines
|EsterelGrammar: The grammar for the language
|The Esterel Grammar in HTML
|Stephen A. Edwards
|Cristian Soviani
|Jia Zeng
|Copyright © 2006 Stephen A. Edwards
|Updated Wed Jul 6 09:17:08 EDT 2016
|All Rights reserved


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Bill, What do you think about HMIN? Since the founders of CTRP are also big shareholders of HMIN, and CTRP is a HG re-recomendation. I wonder why HMIN isn't being recommended by GG?Thanks,Kevin
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U.S. consumer sentiment unexpectedly dipped in October to a still-elevated level amid slightly dimmer views of personal finances and the long-term economic outlook, according to a University of Michigan report Oct. 12.
Sentiment index fell to 99 (est. 100.5) from prior month's 100.1 Current conditions gauge decreased to 114.4 from 115.2 Expectations measure slid to 89.1 from 90.5
This week's sharp drop in U.S. stocks overlapped with survey interviews by only one evening, "having virtually no influence on the early October data," according to the report. The poll was conducted from Sept. 26 through Oct. 10, the day the S&P 500 index fell by the most since February.
Even so, a gauge of current views on personal finances fell to the weakest level since May, and the outlook for finances also softened. The median expected gain in Americans' income weakened to 1.7% from 2.1% in September, according to the report.
The report said confidence in the government's economic policies rose in October to the highest in more than a decade, a potential positive sign for Republicans ahead of midterm elections that will decide control of Congress. The broad sentiment gauge still is hovering around elevated levels that reflect a strong economy, tight labor market and benefits of tax cuts, despite an escalating trade war with China.
The report also showed consumers anticipate faster gains in prices over the coming year. Inflation expectations for the year ahead rose to 2.8% from 2.7% in the prior month, while the inflation rate over the next five to 10 years was seen at 2.3%, down from 2.5% in the previous survey.
"Consumer sentiment slipped in early October, although it remained at quite favorable levels," Richard Curtin, director of the University of Michigan consumer survey, said in a statement. "Unfortunately, the downward revisions in the pace of growth in household incomes were accompanied by upward revisions in the year-ahead expected inflation rate."
A measure of buying conditions for long-lasting goods rose to the highest since June Views of buying conditions for vehicles deteriorated, with 16% of consumers, the smallest share since 1984, citing "low and attractive pricing."


text: B BSJoker Diabloii.Net Member Feb 6, 2004 #1 Sup people New here so what up dogs? Used ta do lots of sp even had a few level 70s-80s, but after getting good dsl i kinda faded away but now thankfully im back. Just started a hc sorc level 9so far.


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Goody Tiptoes picked up the nut bags and went home. She made a cup of tea for Timmy; but he didn't come and didn't come.
Goody Tiptoes passed a lonely and unhappy night. Next morning she ventured back to the nut-bushes to look for him; but the other
unkind squirrels drove her away.
She wandered all over the wood, calling—
"Timmy Tiptoes! Timmy Tiptoes! Oh, where is Timmy Tiptoes?"
In the meantime Timmy Tiptoes came to his senses. He found
himself tucked up in a little moss bed, very much in the dark,
feeling sore; it seemed to be under ground. Timmy coughed and
groaned, because his ribs hurted him. There was a chirpy noise,
and a small striped Chipmunk appeared with a night light, and
hoped he felt better?
It was most kind to Timmy Tiptoes; it lent him its night-cap; and the
house was full of provisions.


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A deckchair for headstock? a pushchair…
A deckchair for headstock? a pushchair for the walks? A simple chair? it is certain that the little girls will find many uses with this wood buggy.
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- Brand : Egmont Toys
- Manufacturer reference : 510500
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Authors : Natália Martins Flore, Priscila Muniz de Medeiros
This study analyzes the legitimation strategies displayed by YouTubers of the 10 most popular science channels regarding YouTube Brazil. Using Discourse Analysis from a French perspective, it unfolds the ethos of the YouTuber, the preferred discursive scenographies, and kinds of contents and discursive approaches of these channels.
The results show the predominant presence of didactic scenography, followed by commentary, scientist-in-action, and journalist scenographies. They unfold themselves in monologue, questions and answers, live experiments, whiteboard videos and short documentary subgenres.
The discursive ethos presents the YouTuber as an informed person who has knowledge on science subjects, teaching them to his audience or commenting on a certain theme or topic. Legitimation strategies come from personal experiences and rarely from a scientist's identity, despite the YouTuber may use scientific authority in some cases.
The use of humor in enunciations and video editing, the reference to pop culture, and the use of an informal language, show the tendency that these channels have in presenting scientific themes in a soft and interesting way.


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National Media Highlights
Huffington Post | April 29, 2014
Dr. Kevin Simmons, Professor of Economics, posts an article about recent tornado damage in the South and its economic impact.
USA Today | April 21, 2014
The Monterey, a restaurant owned by Chad Carey '99 and his wife, Kate '00, ranks as one of the top 10 "best foodie spots' in San Antonio.
University Business | April 30, 2014
Austin College's IDEA Center is featured as one of several prominent science centers.
Dallas and Regional News
AIA Dallas | April 17, 2014
Dr. Pete DeLisle, was interviewed for AIA Dallas magazine. He has founded three successful companies and acted as an advisor, consultant, and teacher of leaders in more than 200 companies and communities over the last 30 years.
Dallas Committee on Foreign Relations | April 21, 2014
Austin College hosts Julia Marton-Lefevre to discuss topics such as "Saving Nature: Why Bother?" and "Challenges & Opportunities of Influencing Environmental Policies at the International Level."
Fox 26, Houston | April 11, 2014
Dr. Ashwini Reddy '03, of Allergy and Asthma Associates, interviews with Fox 26 about how to battle Houston allergies.
KRGV, Rio Grande Valley | March 31, 2014
Bill Luthans '77, leader of Region 6 dive team, led a dive in Donna, TX to search for possible sources of PCBs.
Texas Monthly | April 9, 2014
Lisa Fain '91, author of The Homesick Texan Cookbook, releases a second cookbook and talks about her deep Texas roots.
Local Media Highlights
Austin College | April 4, 2014
Austin College junior Sophie Higgs of Tulsa, Oklahoma, is one of 50 students across the U.S. to receive a prestigious Udall Scholarship for undergraduates intending to pursue careers related to the environment.
Austin College | April 7, 2014
President Marjorie Hass announces the 2014 Commencement address at the College will be presented by Ron D. Burton, 2013-2014 president of Rotary International (RI).
Austin College | April 7, 2014
Randi Tanglen, Austin College assistant professor of English, will be an invited speaker at the University of Texas at Arlington symposium "Frontier Odyssey: The Lives and Legacy of Cynthia and Quanah Parker."
Austin College | April 7, 2014
Dr. Gaspar Real, professor and researcher at Autonomous University of Querétaro (UAQ) in central Mexico, spoke at Austin College, presenting "Social Networks, Innovation, Tradition, and Small Businesses in Rural Mexico: An Anthropological Study."
Austin College| April 9, 2014
Austin College's IDEA Center has been awarded LEED® Gold, a rating system established by the U.S. Green Building Council and verified by the Green Building Certification Institute (GBCI).
Austin College| April 10, 2014
Sallie Sampsell Watson, missional presbyter/stated clerk for the Presbytery of Santa Fe, New Mexico, and a 1978 graduate of Austin College, will present the Austin College Baccalaureate sermon.
Austin College| April 14, 2014
Dr. Marjorie Hass, president of Austin College, has been elected to the eight-member Executive Committee of the Council of Independent Colleges (CIC) Board of Directors.
Austin College| April 14, 2014
The Austin College Department of Art and Art History is the exhibit "Small Pleasures III" through May 2 in Dennis Gallery of Betsy Dennis Forster Art Studio Complex.
Austin College| April 18, 2014
Austin College's dance team, the Aussies, will present its annual Spring Show, May 3. The 2014 theme for the annual fundraiser is Disney: "A Dance is a Wish Your Heart Makes."
Austin College| April 21, 2014
Spanish playwright Antonia Bueno visited Austin College April 21 and 22, offering two presentations, which were translated into English by Austin College students.
Austin College | April 23, 2014
Students from Dr. David Aiello's biology lab participated in the 2014 Southeastern Regional Yeast Meeting this spring at Vanderbilt University in Nashville, Tennessee.
Austin College | April 24, 2014
Austin College students participated in the campus' fifth annual GreenServe, volunteering at a number of sites where their service focused on environmental responsibility and sustainability
Austin College | April 25, 2014
Austin College's Hispanic student group, Los Amigos, will host a Cinco de Mayo celebration on campus Sunday, May 4.
Austin College Roos | April 26, 2014
Men's tennis player David Smith has been named the Southern Collegiate Athletic Conference Player of the Week. Smith is the second 'Roo men's tennis player to earn this honor in 2014.
Austin College Roos | April 17, 2014
Men's tennis player Jack Kunde has been named the Southern Collegiate Athletic Conference Player of the Week, after an outstanding week in which the 'Roos played three matches.
Austin College Roos | April 17, 2014
Women's tennis player Sophie McDonald has been named the Southern Collegiate Athletic Conference Player of the Week. McDonald was superb last week, going undefeated in three matches.
Austin College Roos | April 26, 2014
Austin College softball players Taylor Steelman, Briana and Sophia Hernandez, Victoria Herrera, Emily Low, and Mallory Rossmann have each been named All-Southern Collegiate Athletic Conference players for the 2014 season, the league office has announced.
Herald Democrat | April 5, 2014
Austin College receives $500,000 tech grant for digital education from the Andrew W. Mellon Foundation. It is aimed at enabling AC professors to develop new and creative ways of using digital media to give students a better learning experience.
Herald Democrat | April 11, 2014
Quilts bear witness to local AIDS victims, dozens of hand-stitched names of local AIDS victims adorn this quilt on display at Austin College.
Herald Democrat | April 13, 2014
Austin College hosts student leaders of Taiwanese protests, Wei Yang and Huang Yu-fen.
Herald Democrat | April 14, 2014
Taiwanese protest leader, Yang Wei, visits Austin College, urges vigilance to protect democracy.
Herald Democrat | April 20, 2014
Austin College offers an evening of chamber music and jazz under the direction of Dr. Ricky Duhaim.
Herald Democrat | April 28, 2014
Princeton Review recognizes Austin College for great strides in sustainability and the only private college in Texas to receive the honor.
The Howe Enterprise | April 21, 2014
Austin College will induct the late Tommy Skipworth '67 into the Hall of Honor this July.
KTEN | April 15, 2014
The instrumental ensembles of Austin College, under the direction of Dr. Ricky Duhaime, will present their annual spring concert on April 21, at 7:30 p.m., in Wynne Chapel at Austin College.
KXII | April 8, 2014
Annual Austin College/AC Cares Spring AIDS Quilt program will be held Thursday, April 10. Local AIDS quilts will be on display. Students, faculty, and staff will be encouraged to be educated and compassionate about AIDS/HIV.
KXII | April 8, 2014
Austin College has been awarded a three-year $500,000 dollar grant for digital communications.
KXII | April 17, 2014
Austin College's Center for Environmental Studies will host a public lecture by Julia Marton-Lefèvre, director general of the International Union for Conservation of Nature (IUCN), on Monday, April 21.
North Texas e-News | April 1, 2014
Austin College announces vocalists that will perform in the year's final performance at the Choral Concert on May 10 at 7:30 on campus in Wynne Chapel.
North Texas e-News | April 21, 2014
Austin College hosts discussion "The Bible and the Liberal Arts" as a part of the 2014 Austin College Cunningham Lectures that will include will include chaplains and Bible professors from historic Presbyterian Church (USA) colleges.
North Texas Young Professionals | April 9, 2014
Join NTYP for our 10th Pillars Forum! This time we'll be hearing from Dr. Marjorie Hass as she shares her experiences and hopes for our future.
Dallas Morning News | April 21, 2014
Dennis Ahlburg notes that it's a college degree that lifts earnings.
Inside Higher Ed | April 24, 2014
Ry Rivard looks into what people actually want. The survey – a joint project of Public Agenda, the Kettering Foundation, and the National Issues Forum finds that most of the participants in his study were college students, and don't want the country's colleges and universities to abandon philosophy and the liberal arts.


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Updates to the inventory.
Updated door.
I feel weird about doing this, but I'm adding Bering Lusk as a set piece/medium-size thing, as she is a 1:6 scale mannequin.
This entry was originally posted at http://modernwizard.dreamwidth.org/1566315.html. You can comment here, but I'd prefer it if you'd comment on my DW using OpenID.


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The Bold and the Beautiful spoilers tease that Steffy (Jacqueline MacInnes Wood) will remain mum about her tryst with Dollar Bill (Don Diamont) for the moment. However, her emotions are frazzled and maintaining this incredible secret will create an increasingly weighty mental burden. However, B&B fans wonder if Steffy will eventually pull a Liam (Scott Clifton) and spill her guts about what happened?
Liam made a boneheaded choice when he felt compelled to come clean with his wife. If he had been having an affair with Sally (Courtney Hope), or chose to passionately kiss her in her office under normal circumstances, then his admission would have been advisable. In those scenarios he would have been unburdening his soul.
Yes, Sally and Liam did kiss each other twice on the Spectra Fashions' grounds. As viewers know, those characters were literally lying on the grounds, pinned by fallen debris after the building was brought down. They thought their lives were about to end and shared an understandable moment.
If Liam wouldn't be such an analytical goof he would have realized that Steffy would be instantly devastated by his dramatic description of said circumstances. His presentation of the event naturally pushed Steffy's buttons because of who he specifically kissed.
Steffy then ran to Bill, a former flame who she'd been consoling in recent months. Dollar Still was revived, which reminded the momentary lovers that they were seemingly better-paired then Bill was with Brooke (Katherine Kelly Lang) or Steffy was with Liam.
But upon awaking after the physical workout, Steffy realized what she'd done and was horrified. Bill, had a different reaction. He was convinced that Steffy would tell Liam what happened and leave her husband. Dollar Still would then leave the country to celebrate their long-delayed pairing.
Steffy felt differently and was further overwhelmed by Liam's pop-up remarriage plan. Leffy renewed their vows and that was that, until Steffy's guilt burrowed deeper into her soul within the last week-plus.
Only Dollar Still fans, or those who think Liam is a jerk want Steffy to tell her husband what she did. But maybe there's one person who actually wants that scene to play out as well?
If Steffy believes, underneath it all, that Diamont's character is her actual better half, then she will tell Liam what happened. Yes, Steffy may purposely sabotage her marriage in order to open the door to Bill without even fully realizing that her subconscious had driven her to do so.
CDL is a leading source for everything linked to The Bold and the Beautiful. Check back regularly for B&B spoilers and news!
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Ben Bunch
I got my Lumix GH1 recently, shot this test with it the next day; never touched one before. Threw it together with some music in Final Cut Pro, quick color work in Magic Bullet Looks, and on to the Vimeo.
Used the stock lens and a Nikon 50mm (f1.4.) I had to shoot most of the stuff at fast shutter because I have no NDs yet. Managed to catch myself in a few reflections too. Tried for a variety of shots.
Shot 720/60p. Haven't noticed any banding or macroblocking ("mud") problems really. There is a bit of fuzziness in the water-spray, aggravated by web compression, I think it would have been better at a slower shutter but that was not an option.
Shot with lowered sat, contrast, and noise reduction, to boost my leeway in post.
The camera was a joy to shoot with; this shoot took about an hour total, maybe less--much easier to deal with than a shoot I had about a week back using HVX-200 + Letus.
Song is "Happiness" by Kasabian, off their new album "West Ryder Pauper Lunatic Asylum."
Let me know what you think or if you have any questions!


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Shell Beach is unique on St. Barths because it's the only major beach located in a town and is known for the millions of unique shells that wash up here.
Shell Beach is within walking distance of the capital city of Gustavia, which often hosts weekend festivals on the shore.
Shell Beach usually has calm waters and is a welcome respite after a day spent in the shops and boutiques in town. For a little adventure, there's the opportunity to do some cliff-diving, and plenty of restaurants for lunch, dinner, and cocktails by the sea.


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Meet our Members: Ryan
Ryan has created beautiful art for much of his life – he started sketching when he was just 3 years old! It is simple for Ryan; he says art is a lot of fun and showing off his creations is something that he will forever enjoy. You may see Ryan out in the community displaying his art at local shows and sharing the stories behind his work. Ryan will even take personal requests and creates his own wooden frames to further personalize his work.
You can see more of Ryan's art online athttp://artworking.org/


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At Capital Coating, we provide our customers with a wide variety of commercial roofing services in Pittsburgh, PA in order to completely customize your commercial roofing experience. We don't just give our customers one repair option, we give them many. We don't just provide them with one roofing service, we offer a whole list of services because we are a versatile, full-service company. No matter what your commercial roofing needs are, give Capital Coating a call now and we can give you an affordable solution that is tailored to you. Call us at (717) 442-0979.
Variety Equals Customization
Unlike many roofing companies in the area, Capital Coating doesn't just give you one roofing solution. We know that each project is different and we treat our customers as individuals. After a comprehensive inspection, we set down with you to customize a plan for your project that fits your needs. Some clients want to save money on their energy bills, some want quick and simple roofing solutions, while others want a specific roofing system such as single-ply roofing. As a full-service company, we are able to accommodate all of our clients and we maintain a reputation as a company that delivers. Some of our many services include:
- Waterproof Roof Coatings
- Elastomeric Roof Coatings
- Commercial Roof Restoration
- Commercial Roof Repair
- Commercial Roof Replacement
- Spray Foam Insulation
- Spray Foam Roofing
- Commercial Painting
- Sand Blasting Services
- Roof Inspections
- Roof Maintenance
- Flat Roofs
- Single-Ply Roofing
- Cool Roofs
Any Type of Roof
Our commercial roofing services in Pittsburgh, PA can extend the life of your roof by years, are virtually maintenance-free, and come with warranty options to give you peace of mind. We service, repair, and replace all types of roofs including metal, PVC, TPO, EPDM rubber roofing, modified bitumen, and built-up roofs. Once your roof is repaired, you can schedule routine maintenance inspections. Studies show routine inspections can potentially double the lifespan of your roof by catching problems before they do damage.
Let The Expert Handle It
With 20+ years experience in the industry, our skilled and trained technicians are prepared for whatever roofing challenges you have. Call Capital Coating today at (717) 442-0979 to learn what your roofing options are and to schedule your free roofing evaluation.


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See Viral Pre-wedding Photos Of FRSC Officer And Fiancee That's Got Everyone Talking
GC Posted On: Jun 11, 2017
This FRSC officer met his woman, they fell in love and he literally carried her home. They are getting married soon and their pre-wedding photos have gone viral.
Many Nigerians think he's Goliath and his bae, David, the 'David & Goliaht' couple.
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*Above interior by Jessica Lagrange Interiors
Designing with only white is not for the faint of heart, but there's no denying: it always looks good. Because if there's one design element we're pretty confident you'll never tire of (and re-do in five years), it's white. Clean, warm, and modern, white expands the possibilities instead of narrowing them, making it easier to play with texture, art, and different styles of furniture. Sold yet? See below for inspiration on how to dive into all-white decorating.
Designe Gallerie: Leather Danger Side Table With Gold Spikes
Who said decorating in monochrome had to be boring? An all-white room demands at least one daring statement piece, and this quirky side table perfectly fits the bill. Neutrally colored velvet and leather textures provide a rich framework for these gold and bold spikes. Add some drama to create a space that is daring, never dull.
George Nelson: Large Saucer Bubble Pendant
White is classic and timeless, and maintaining that sophistication while creating visual interest requires a careful balance. Modernize this minimalist approach with sculptural lines and contemporary styles. Take it from the top and start with your highest accessory – lighting! Designed in 1952 for the Herman Miller furniture company, this pendant light was directly inspired by the early modernism movement. It doesn't get more iconic than that.
Shine By Pasargad: Mongolian Wool Ottoman
At first glimpse, this whimsical ottoman is almost too fantastical to be functional. It might, however, be the ultimate accessory for your all-white palette. It's both delightfully eccentric and completely comfortable. You'll be sitting pretty when resting your feet on this plush Mongolian wool upholstery. Visually airy and light, this Pasargad piece allows you to shake things up without stealing the show. Why settle for less?
B&B Italia: P60 Ottoman
Texture is key for adding depth, interest, and style. Plus, with an all-white color scheme, you have so much more freedom to play with! By combining sharp and clean lines with hair-on pony hide, B&B Italia has created a visually surprising ottoman that's a perfect addition to any neutral room.
Milo Baughman: Vintage Barrel Chair
If every piece is loud, it'll feel as if the room is shouting at you. But that also doesn't mean a monotone room or its furniture should ever be monotonous. With tufted details and a gorgeous shape, this contemporary barrel chair is the perfect foundational piece to build a room around. Cozy up with this beautifully simple style!
Eero Saarinen: Tulip Chairs
When done wrong, an all-white room can feel rigid and sterile. To build a space that's relaxed and comfortable, furniture should look inviting and… comfortable. Creamy cushions and sturdy stems on these tulip chairs will keep diners lingering long after the meal is over.
Charles and Ray Eames: Elliptical Table
Artemide: Castore Large Floor Lamps
These floor lamps embody the perks of an all-white look. They're airy and refreshing, sophisticated and crisp, and quietly demand attention. While a glossy lighting finish could reflect too much light off all this white, these opaque white globes will warm up your space.


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9 Habits That Can Wreck Your Teeth
Avoid these pitfalls to protect your pearly whites
You bite down on a piece of hard candy, a stone that accidentally got into in your bean soup or a piece of shell from a nut and suddenly — crack! — a piece of your tooth chips off.
You may not be able to avoid the random stone in your food (though you should always rinse dry beans and carefully pick through them before using), but there are plenty of other dental hazards you can avoid by changing a few bad habits. Here are nine to avoid if prefer not to chip, crack, loosen or wear down your teeth.
Related: What's the Safest, Most Effective Way to Whiten Your Teeth?
Sipping acidic drinks all day. When you drink pretty much anything besides plain water, you're creating an acidic environment in your mouth, which can cause cavities, says Maria Lopez Howell, DDS, a consumer advisor for the American Dental Association. So, if you're going to drink coffee, soda, sports drinks, tea or even zero-calorie flavored sparkling water, do so with a meal, then give your mouth a rest. That means you should enjoy your meal (or healthy snack) in one sitting. Avoid sipping, munching and chewing throughout the day. After you eat or drink, your saliva can take your mouth from acidic to neutral in under an hour, Howell says. "Saliva has wonderful healing properties."
Eating hard candy. With hard candy, there are two ways to eat it: chew it — a huge no-no — or let it slowly dissolve in your mouth. Option one can chip or crack your teeth. "They're called jawbreakers for a reason," Howell says. Option two gives bacteria in your mouth plenty of sugar to feed on and creates an acidic environment while the candy is sitting in your mouth.
Chewing on ice and other hard stuff. Don't chomp on ice, fingernails, pens or other hard items, which all can chip your teeth, especially if you have dental work such as crowns or veneers on your front teeth, Howell says.
Using your teeth as tools. Forget about opening packages with your teeth. "Don't use your teeth as tools — we have scissors and fingers for that," she says.
Related: 6 Surprising Ways to Brush Your Teeth Better
Using homemade toothpaste. There are plenty of recipes online for making toothpaste with baking soda that will supposedly whiten your teeth. But baking soda can damage your enamel, Howell says. Skip the homemade paste and use an ADA-accepted toothpaste with fluoride, she recommends. And if you need your teeth whitened, talk to your dentist, she says. (A toothpaste is probably not the best way to do it.)
Carrying pencils in your mouth. Don't walk around with pens, pencils or other items in your beak, Howell says. "You could bump into a wall or fall and all of sudden you hurt your teeth, gums or tissues in your mouth."
Getting your tongue or lip pierced. It might look cool (at least to you), but an oral piercing can harm your teeth, gums and fillings, according to MouthHealthy.com, a website from the ADA. Often, people with piercings develop a habit of clicking the metal against teeth, according to the ADA. Dentists sometimes see fractures on the insides of teeth in patients with mouth piercings, says Howell. Piercings also can cause scratches on the teeth and tooth sensitivity, according to the ADA. If you do have a piercing, avoid clacking it against your teeth and be careful when chewing and talking, the ADA recommends.
Related: 5 Things You Didn't Know About Flossing Your Teeth
Playing sports without a mouth guard. Many sports aren't kind to teeth — just ask any hockey player. Tooth fractures, loosened teeth and knocked-out teeth are unfortunate side effects of plenty of different sports. Mouthguards can help reduce injury to teeth not just in contact sports like hockey, boxing or football, but also in other sports, such as gymnastics, according to the ADA. The organization recommends mouthguards for almost 30 sports, including acrobatics, basketball, bicycling, ice hockey, martial arts, skydiving, water polo and wrestling. If you play a sport, talk to your dentist about what kind of mouthguard to get.
Grinding your teeth. Stress can lead to teeth grinding, also known as bruxism, which often happens while you're asleep, according to MouthHealthy.com. If you grind your teeth, you probably can't stop, Howell says. But using a night guard is one simple way to protect your teeth, she says. If your teeth grinding is caused by stress, counseling, exercise ad meditation might help, according to the ADA.
It's also important to brush twice a day for two minutes, floss once a day and visit your dentist regularly. Notes Howell, "Once you've got your adult teeth, you don't get another set."
Related: Why Your Gums Are Receding


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Biodiesel And Small Batch
You can prepare bio diesel in small batch by using Dr. Pepper techniques. But be careful in bio diesel making as some chemicals are poisonous. Arrange for proper safety to you and your surroundings. If you inhale any vapor it will be harmful to health. So take adequate precautions to prevent yourself. Wear chemical proof gloves and glass for eye protection. You need Methanol to produce bio diesel. Be careful while handling methanol as it is poisonous and can be absorbed through skin or inhalation. It may even cause blindness or death. But it is safe to prepare with sufficient protective measures.
You can use any oil either new or used. Heat the oil until the water in it is being removed. If there is more water then the oil will pop on heating. So be careful. Once the oil is heated allow it to cool. You can ensure that water is removed from the oil when there is no sound in the oil. Mean time mixes the methanol and lye (NaoH). Mix 250 ml methanol and 4 g lye. The lye should be dissolved in methanol. You can stir it with a spoon.
Then pour the mixture in the oil with the help of a funnel. Then close the bottle and shake it for 10 minutes. Place the bottle on the table. Then you will notice that all the by products settled down within 10 minutes and you will get the bio diesel.
You can prepare bio diesel in mall batches for home use. There are number of techniques that can be applied according to your convenience in producing bio diesel in small batches. You can also get used oils from restaurants to make bio diesel. The lye and methanol can be obtained easily from chemical shops. So you can try to produce bio diesel in small batch first. When you got success in preparing small quantity of bio diesel then you can use processors and start producing for home use.
The main process of transforming used or new oil to bio diesel by mixing some methanol is called transesterfication. If you use waste vegetable oil then you have to purify the oil by removing the dirt. At home you can heat the oil at 120 degree boiling point. This will remove all the water from the waste vegetable oil. The resulting product will be dark brown in color. You can also make bio diesel from new oil.
If you prepare bio diesel in small batches at home, you should remember that you should not inhale any fumes. You can not use cartilage respirators here as they do not protect against methanol. Also remember that methanol and lye will not mix immediately. You have to mix them. Do not warm. The body temperature is enough for mixing. You can take even 10 minutes in mixing. Stir with a spoon. Always use gloves. You can also mix by shaking the bottle. Then you can add extra methanol because sometimes methanol may evaporate in mixing. The bio diesel will be unclear. It will take time to settle the by products and get the pure bio diesel.


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Are you hesitant to smile or laugh in front of others simply because you feel conscious about your teeth? Having pearly white teeth can certainly boost your confidence, and thanks to Affinity Dental Group, you can now enjoy that beautiful smile you've always dreamt of.
You'll acquire a confident, sparkly smile in no time with the best teeth whitening Kissimmee FL has to offer. Our team of dental and oral professionals will ensure that you get the best service possible using world-class tools and equipment.
When it comes to teeth whitening and teeth bleaching, Kissimmee residents can lay all their trust in Affinity Dental Group.
Why do teeth become discolored?
Teeth whitening and teeth bleaching are critical dental procedures that become necessary when your teeth have become discolored. Over time, they can become stained as they tend to come in contact with all kinds of external agents. These include:
Food and drinks: Usually, the number one cause of tooth discoloration is the variety of food and drinks you consume. Especially if you happen to drink a lot of dark-colored beverages such as coffee, red wine, tea, and certain aerated drinks, your teeth are more likely to become stained. This is because these products have strong pigments known as chromogens which attach themselves to the white, outer layer of your teeth.
Tobacco: Another common culprit of tooth discoloration is tobacco. The more you smoke, the higher your chances are of having stained teeth. Tobacco contains tar and nicotine, both of which cause stubborn stains on your teeth. While tar has a natural dark color, nicotine turns yellowish when it is mixed with oxygen, leaving your white teeth with unsightly, yellow stains.
Medications: Medications such as certain antipsychotics, antihistamines, and various hypertension medications can cause tooth discoloration. Other treatment options such as head and neck radiation and chemotherapy can also cause similar discolorations.
Trauma: If you have suffered dental trauma, such as hitting your mouth against a hard object, then it is possible that discoloration may appear. This is due to the fact that when your tooth reacts to an injury, it produces more dentin, which is a dark layer found under the enamel.
Poor oral hygiene: If you practice poor oral hygiene and you don't take proper care of your teeth, then stains are likely to form over time. For example, not brushing or flossing regularly can be culprits.
Teeth Whitening Vs. Teeth Bleaching
If you experience tooth discoloration because of any of the reasons mentioned above, then the smartest solution is to opt for the best teeth bleaching and teeth whitening Kissimmee has to offer. Head to Affinity Dental Group. This is where our team will ensure that you undergo a safe, comfortable, and fruitful procedure that will leave you with sparkly whites.
So now the question that arises might be: are teeth whitening and teeth bleaching the same? If not, which one should you opt for? You may think that these two common procedures are one and the same since they are used interchangeably so often. But according to the American Dental Association (ADA), they do have a small difference.
Teeth whitening is a process where the natural color of your teeth is restored by removing stains from the outer layer of the tooth. On the other hand, teeth bleaching is a process that whitens teeth beyond the natural color.
So for teeth whitening, Kissimmee residents can use cleaning agents that are commonly found in toothpaste and mouth rinses, while for teeth bleaching, they will have to look for professional treatment since chemicals like hydrogen peroxide and carbamide peroxide are used.
Despite this difference between the two procedures, teeth whitening and teeth bleaching are still denoted interchangeably. They are both used to refer to the process of removing stains from your teeth so you can have a whiter and brighter smile.
Professional Teeth Whitening and Teeth Bleaching for a Beautiful Smile
At Affinity Dental Group, we provide the best teeth whitening and teeth bleaching Kissimmee has available. We want you and your family to be confident in your smile, and our team of professionals works hard to ensure that we make this possible in a safe environment where you feel at ease.
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Discussion Board for collaboration related to QlikView App Development.
I need to load in QlikView GPS data regarding our company's cars. In the database where the data is kept there 2 tables that i use:
KmData - it contains the car's position at a given time (latitude and longitude), and other info: driver, speed, distance, etc
Locations - a list with points of interest (POI) which contains our customers addresses. These are defined using map 2 coordinates that form a square with a 100 meters side (LatitudeMin, LongitudeMin, LatitudeMax, LongitudeMax, LocationName).
The problem is i need to find connection between this 2 tables, but they don't share a common field. The link can be made by verifying if a location from which a car sent a signal (from the KmData table) is inside a square from Locations table. The formula is:
if(LatitudeMin<=Latitude and Latitude<LatitudeMax and LongitudeMin<=Longitude and Longitude<=LongitudeMax, 1)
I tried using this in the interface in a straight table, but because the data volume is very large (we have over 400000 lines in KmData every month and about 3500 rows in Locations), the table is calculated very slowly (i tried with only a couple of days and it was really slow).
I'm thinking i should somehow make this calculations in the script, but i don't know how.
Any suggestion is most welcome
I solved the problem.
I used the IntervalMatch function and it worked.
View solution in original post
Can you help me understand how did you use INTERVALMATCH() for this?
I have a table containing Mapping information
And another data which has information about my origin Lat lon and Dest lat long and other parameters. I am trying to map out the GeoData into the second table.
How should we use Intervalmatch for this?


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European stocks have risen as investors took their cue from better-than-expected earnings from US aluminium giant Alcoa and after the eurozone released billions of euros in fresh aid for Greece, dealers say.
Meanwhile, economy and finance ministers from all 28 European Union countries gave the final green light to Latvia to join the eurozone from the start of 2014.
In late morning deals on Tuesday, London's FTSE 100 of leading companies advanced 1.01 per cent to 6,515.45 points and Frankfurt's DAX 30 gained 1.15 per cent to 8,059.84.
In Paris, the CAC 40 increased 0.79 per cent to 3,853.88 points, as investors also welcomed an electricity price tariff deal for energy giant EDF and takeover news in the fashion sector.
The European single currency rose to $US1.2880 from $US1.2868 late in New York on Monday. Gold increased to $US1,253.90 an ounce from $US1,235.25 on Monday on the London Bullion Market.
Sterling fell sharply against the US dollar and euro, after British manufacturing output and industrial production data disappointed the market.
"European markets are nicely up in green, adding to previous session's gains," said Gekko Markets analyst Anita Paluch.
"Two factors are the reason - better than expected Alcoa results and its upbeat forecasts that traditionally start the earnings season and the good news from the European front, where Greece secured the 6.8 billion euro tranche of financial aid ... which will prevent the default of the country's debt in August."
Eurozone finance ministers agreed in Brussels late on Monday to unlock the billions of euros in fresh aid for Greece on condition it presses ahead with urgently needed reforms.
The eurogroup gathering was held ahead of Tuesday's meeting of EU finance ministers, who have rubber-stamped Latvia to become the 18th member of the eurozone with effect from January 1, 2014.
Alcoa meanwhile revealed overnight that losses deepened in the second quarter from a year earlier as a result of lower aluminium prices and special charges related to capacity reduction and a US probe into offshore bribery, the company reported.
The aluminium producer said it lost $US119 million ($A131.04 million) for the quarter ended June 30, compared with a loss of $US2.0 million in the year-ago period.
However, excluding the charges, Alcoa reported earnings of $US76 million or seven US cents per share. That was one cent more than analysts' expectations.
"With Alcoa kicking off the earnings season in style last night and numbers topping estimates, there appears to be a degree of confidence about the round of corporate numbers we will be seeing in the coming days," said Mike McCudden, head of derivatives at online broker Interactive Investor.
In Paris on Tuesday, EDF rocketed to the top of the risers board, soaring 9.43 per cent to 19.43 euros after the energy giant clinched a new electricity tariff deal.
The French government authorised EDF to lift its electricity prices for residential consumers by 5.0 per cent next month, and by the same proportion in August 2014, in order to offset rising costs.
Separately, French luxury conglomerate LVMH agreed on Monday to take control of Italian exclusive ready-to-wear fashion group Loro Piana by buying an 80 per cent stake for about 2.0 billion euros ($A2.84 billion).
The deal sent LVMH shares 1.86 per cent higher to stand at 131.15 euros on Tuesday.
Across in London, Royal Dutch Shell saw its 'A' share price jump 1.08 per cent to 2,152 pence, as investors welcomed the appointment of downstream head Ben van Beurden as its new chief executive with effect from January.
British retailer Marks & Spencer saw its shares slide 1.85 per cent to 451.20 pence after posting weak first-quarter sales.


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How to Stock Your Home Bar the Right Way
19 March 2020, 14:14
If you like entertaining, are a budding mixologist, or simply like to have a nice drink from time to time, having a fully stocked bar can be a great addition. However, this can be an intimidating project if you don't know where to start.
You'll need to have all the essential equipment and the additional accessories that will make your bar a place you'll actually want to hang out in. You also want to make it as comfortable as possible for your guests, and consider entertainment options as well. But the foundation of a great home bar starts with your selection. Let's take a look at how to stock your home bar the right way.
Start with Things You Actually Enjoy
The first step is to make sure that you pick things that you actually enjoy drinking. Don't make the mistake of buying expensive or exclusive bottles just to impress everyone. However, you should make sure that you keep a few bottles for special occasions.
You should at least consider having a few bottles of champagne. You can buy champagne online from most brands and in different formats. However, you should remember that you are your bar's best customer, so whatever's your favourite should always be in stock.
Choosing based on your preferences also allows you to showcase your taste and introduce your guests to something new. This will make great conversation fodder and could be much more impressive than that 1960 bottle of Petrus you'll probably never open.
Start Small
Another thing you should do is start small at first and build your collection. While you're your bar's main guest, you still want people to be happy. So, instead of spending tons of money at the start, buy a few essentials. This way, you'll be able to tell which drinks are the biggest winners, and stock accordingly.
Know Your Main Spirits
Spirits will usually be the stars of your selection, so make sure that you get to know them. One of the most important ones you should have is gin.
Gin is a very versatile spirit that is used in a whole variety of cocktails, like Old Toms, Genevers, and London Drys. So, we suggest you always keep a few bottles in stock.
Vodka is another very common spirit for mixing. It doesn't have a very strong taste, and is essential if you like your Cosmopolitans. They come in different varieties, including potato, sugar cane, and grain, and all have their own characteristics. So, you'll have to try different ones to see which ones you like the best.
Then you have your whiskeys for straight shots, and your exotics like Rum and Tequila. Rum in particular is one of the best spirits to drink straight, and is great for punches as well. So make sure you stock up on a few high quality rums if you're thinking of entertaining.
Stocking up your house's bar doesn't have to be difficult. Just make sure that you put yourself first and diversify your selection until you get the nod of the pros out there.
Want to Use Your Pots and Pans For Years to Come? Then Follow These 6 Simple Steps
2 September 2019, 17:33
Reliable kitchen utensils aren't cheap. They are usually made of the best material and that is why they cost more than the ordinary utensils you are used to. The same still applies to the pots and pans that you need to prepare meals for your loved ones. (more…)
3 Benefits of Ordering Food Online for Restaurants
28 January 2019, 00:24
Restaurants are used to offer their customers menu choices about taking out and delivery services. An employee of the restaurant answers the order by phone and delivers it to the kitchen for preparation. When this order is completed, the customer is responsible for assuming responsibility in front of the restaurant. This ordering process is changing. Thanks to modern technology, more and more people order food and drinks online.
Dark Chocolate Banana Bread
12 September 2018, 15:26
Dark Chocolate Banana Bread (more…)
Using Chocolate to Make Delicious Cocktails
25 May 2018, 18:23
Chocolate is a perennial favorite of many people, which is why it is incorporated in a lot of things. Among others, one of the most innovative ways to use chocolate is to have it infused in a cocktail. How exactly is such possible? Keep on reading and we'll share some basic recipes that will turn you into an expert mixologist at home! (more…)
Inspired Space Saving Ideas for your Countertop
25 May 2018, 13:52
Trying to prepare meals on cluttered work surfaces is enough to put anyone off cooking from scratch. Because we all have so many freestanding gadgets these days, finding or creating alternative homes for things becomes less of a luxury and more of a necessity. Here are some ideas to help you reclaim your countertops so you can use them less for storage and more for food and drinks prep. (more…)
Italian Desserts That Will Make You Drool
17 May 2018, 19:30
When dining in an Italian restaurant, such as the infamous Scarpetta in New York City, we often think of pasta and pizza. They are the perennial favorites and the most recognizable of the Italian dishes. Their desserts are often overlooked, although I doubt that the latter will still be the case after reading this post. We will briefly list down some of the mouthwatering desserts that will make you realize why Italy is a paradise for foodies.


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Roman J Israel, Esq is a movie that defies modern forms of correctness with direct truth and can. Denzel Washinghton takes you into a world of a man who beleives in truth as truth, in doing no wrong, in virtuos freedom and movements to advocate for social justice.
A man in his 40s, with a large Afro, bespectacled and with a wimpy walk, he works as a partner in a two person law firm, where he does the backroom work, passionately drowning in legal briefs and with no social addictions of modern life.
This is a man with no facebook, no twitter, a 1980's flip phone, living in a poor neighbourhood but nontheless not ambitious about moving. A man who life is turned upside down in an instant when his partner has a heart attack.
All of a sudden he is forced out of the back office into the courtroom. Asked to do simple things like settle a case for an innocent young black man who was in the wrong place from a harsh 15 years into a slap on the wrist 3 years, he can't accept it…bungles it up, shocked inside into seeing what his partner used to do….and all of a sudden his life is turned upside down. He doesn't know what to do.
This movie is simple: a story about a good man turning bad, and in the process a bad man turning good. Though the cost is immense, a matter of trial, best filed in court as:
Roman J Esq
Roman grows on you, and his supporting cast, by their weakness and sloppy words actually trenghten his case, makes you root for him more. But is it a lost cause? Has the world changed so much that nowadays common decency does not man, that man eat man is accepted, that justice is actually injustice minimized and that doing the right thing can be wrong in the eyes of the one who interprets the law – and you get punished for it.
What is initially intriguing about the movie is the name Esquire. We all know Esquire magazine, but i had to google the word and find out the actual meaning. In fact, someone inside the movie asked him about it. It apparatently has something to do with being more than a Gentelman and just below the level of a Knight, something about being a honorable man, such that lawyers in the US take up the name once they start practising law – it is bestowed and not given.


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Am a smart cook. I realized it, first when I cooked rice years ago…
Cooking rice is very easy- rice , water and a bit of salt in a steam pressure cooker, wait till cooker blows out 2-3 whistles and it's done.Dumb cooks mess up by adding less or more water, dumbest one do not add salt.
Am smart cook. I do everything right.
I just missed one ingredient – water.
The result ? There was no whistle . By the time I realized this, rice had turned into black pebble sticking to the bottom of the pan so very hard that I was feeling bad separating two eternal lovers .Rice refused to come out of pot even after weeks of washing …
Not bad I would say, still in smart category . I just missed 1 ingredient out of 3, that is 1/3rd recall value , memory memorize ,success rate ..blah blah blah.. I think based on this stats ,I should be called above average smart cook ( am feeling so good about writing this post now ..)
My talent doesn't stop here . My husband never forgets to remind me of ONE time , just bloody ONE time , in all of my cooking career when I messed up a particular Indian sweet dish "Halwa", another easy-easy dish with 3 ingredients -sugar , semolina and milk . I forgot ; again just one item….
How bad can a sweet dish be without sugar? I mean really how bad ? Just pour some honey over it honey !!
(One would assume my husband has good memory , but that "one" should wait till I ask my husband about first time I cooked for him and see his good memory show its true color!)
I once mis-read "cut into 1 centimeter pieces" and instead "cut into 1 inches long pieces" and result was raw , plain raw and this I admit was bad reading , not "lack of passion for cooking" issue.
My tea was once labelled gutter water .I meant to cut on some calories with less milk more water..smart move but not exactly drinkable combination for some.
But I will say it's rather smart .
There are more , but am starting to think the reader of post will join my husband next time I make halwa and don't want to give any upper hand to anyone via my blog , any-upper-hand-over-me post goes out of window!
This post is about my smartness in kitchen..
Overtime , I learned to specialize in recipe
- which needs as little time in front of stove as possible…blink and you will miss when I was kitchen cooking..
- which does not ever ever ever needs constant stirring…. just mix all , cover it , low flame and go read a blog.
- measurement is not important and free style hand measurement is just about right.. nothing can go wrong if you add more salt or sugar..
- most important is you are never ever out of ingredients and nothing is a must ingredient ; Sugar isn't important for sweet dish , pour honey ,use chocolate syrup..
- which can be cooked while you can catch your nap ! Yes , remember low flame , plenty of water , and tell husband to keep an eye 🙂
Here is one very much fab chicken recipe..My style chicken..
Out – The Indian version which needs prep and constant stirring , at least 30 minutes in front of stove , an hour in making ! Puff!
In – read , write , watch TV, nap , play and in-between cook chicken!
Take a pot, put chicken(wash and dry) and mix following
- Open kitchen cabinet for spices – add all to chicken , even sambhar powder (its a special for lentil-based vegetable stew only). I have salt , turmeric , chilly ,coriander , mustard and cumin seeds , and sambhar here.
- Open kitchen cabinet for special spices – add all into chicken. I have bay leaf , clove , cardamom , carom seeds et al.
- Open kitchen cabinet for foreign exotic spices– rosemary , thyme , oregano and galangal. If you already live in land of rosemary or galangal , then look at step 1 & 2 again, that might be foreign and exotic for you!
- Open refrigerator, get out bowl of plain curd and add it . No curd – Tell hubby chicken will be a bit dry.
- Check your vegetable compartment and look for fresh herbs – coriander , mint, curry leaves and lemon.
- Look for any vegetable that is lying there since a week .. c'on you need to cook it now , capsicum , beans .. out out out! Not carrot ..you dont want chicken sweet
- Add salt , of course.
- Add green chilly – this is my must have ingredient. Am ardent fan of green chills , it's like oxygen for my food.
- If in mood , cut some onions and tomatoes and add it to pot. Add some garlic cloves .. actually add plenty of garlic.
- Pour in some amount of oil.
- Cover or do not cover the pot, I will leave the choice to you. Put on low flame. That's it , enjoy – watch , sleep .. do whatever you want.
After 10 minutes , ask your husband to go have a look. Is the chicken tender yet?
After another 10 minutes , ask your maid to have a look.Is the chicken cooked?
After another 10 minutes – get your own ass up there and check if chicken is cooked.
Oh yeah , I forgot to tell you -do not add water . All the stuff releases water and its usually not dry. If you have already added water by now , then never mind, you can watch 2 episodes of Big Bang Theory instead of 1 planned.
After 30 minutes ..and Voila !
I tell you its THE tastiest chicken dish ever and smartest too!
I got a pic 🙂
PS: The smartest dish to cook is rice , but , hmm , though its very good for cook , bad for waistline ,so I say ..be smart , skip it.
PPS: Some of the Indian recipe do not come under my specialty , like making roti the Indian bread – its a full time job in kitchen. Be smart , get a cook or roti maker or order.
PPPS: This post makes me eat chicken so much now . I should probably tell cook to make her special konkan style chicken recipe tonight 😉


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- About the Journal
- Editors
- Submissions
About the Journal
As a journal community, we offer the following working definitions to further delineate the scope of our medium:
- Administration: a working structure that combines the creation of policy with the direction of management functions
- Supervision: a supportive structure of authority and delegation that seeks to empower workers through a culture of learning to confidently make efficient, effective decisions in an accessible, cooperative environment
Our mission will be advanced by four primary drivers.
1. Phenomenology
JSAS will shift research focus in the academic field of sport management toward a more precise study of distinct phenomena, ideas, and events.
In his pioneering work regarding phenomenology in the field of philosophy, Edmund Husserl (1859-1938) attempted to shift the focus of philosophy away from large-scale theorization toward a more precise study of discrete phenomena, ideas, and events. Subsequently, French phenomenology philosopher Maurice Merleau-Ponty (1908-1961) once contended that science and too much abstraction had resulted in a philosophical tendency to reduce every phenomenon, every object, and every person to nothing more than collected data. Merleau-Ponty believed that philosophers had a duty to relate things as they were viewed, not as science described them.
The founders of JSAS likewise believe that a distinct lack of congruence exists between academic research and practice in the field of sport management. The founders also believe that this disconnect can be traced to the ambiguous and conflicting goals and expectations of scholarly research, such as:
- Creation of theoretical versus pragmatic knowledge
- Use of data-supported versus logic-driven information
- Use of the scientific method versus case studies
- Prestige of academic-oriented versus practitioner-oriented journals
- Pressures of academic tenure versus the need for organizational effectiveness
JSAS seeks to address such conflicts and narrow the gap between the academy and sport properties by evolving research in practically applicable directions.
2. Development of the Scholarly Sport Practitioner
JSAS seeks to be a channel of pragmatic information that encourages practitioners in the sport management field to champion ethics and pioneer innovation by helping create a greater understanding of the applicability of sport management research to their organizations, job duties, and skills.
The Scholarly Sport Practitioner is the needed next-generation evolution in the sport industry's work force. This worker can cause sport organizations to successfully generate management practices that utilize the power of knowledge as the primary capital of the future economic landscape and marketplace. Accordingly, JSAS seeks to supply this worker with meaningful research that builds his/her knowledge capital base for successful organizational and stakeholder management in the sport industry.
3. Development of Social Responsibility in Sport Organizations Stakeholders
JSAS seeks to publish research that will enable sport organizations and stakeholders to better understand and function in their roles within sport, one of society's more prominent, preeminent, pervasive, and powerful social institutions.
The founders of JSAS believe that, as an institution, sport must begin to fully acknowledge and completely embrace its role as a social product, formulate ethical imperatives to improve society, and generate long-term ideals that are good for society.
For too long, sport as an institution has clung to various defenses of aged clinical, value-neutral capitalism and modern advertisement-based refusals to accept role model functions. In postmodern times, however, sport professionals and organizations must imperatively employ knowledge as their power capital in the competition to shape and define the character and meaning of sport.
Instead of a philanthropically-rooted approach, the founders of JSAS believe that sport must take a socially responsible mindset that can best be described as business activism—an approach that seeks to show the world that business can be a powerful, positive, and progressive voice in society, and accordingly manages organizations to do well (functionally) so they can do good (become forces for positive change in the world).
4. Open-Access
JSAS will be a publication of the Middle Tennessee State University Sport Management program in partnership with the University of Michigan Library's Michigan Publishing (which will house the journal) in order to disseminate research knowledge in a format that is readily and globally accessible to scholars, practitioners, students, media, and the public.
In the Internet age, methods of sharing and using academic research are rapidly, fundamentally, and irreversibly changing, bringing about great potential as a result, including faster and wider sharing of journal articles, research data, simulations, syntheses, analyses, and other findings which fuel knowledge and practice advancements.
In scientific fields, journals have long been the binding glue of a multifaceted system of scholarly communication.
Open-access journals not only recognize and preserve the important role of peer review in scholarly communication but help break down or lower access barriers between the basic functions of journals, including:
- Registration of intellectual property
- Certification of quality/validity of research
- Awareness of new research by potential users
- Archiving of scholarly record for future use
- Rewarding of scholars
To fulfill its vision and mission, the Journal of Sport Administration & Supervision will:
- Apply systems-based thinking and learning approaches to the examination of both classic and new lines of research inquiry in sport to produce a body of knowledge that connects climate, culture, and community to innovation through a greater understanding of the administration and supervision of coaches, sport managers, sport properties, sport organizations, and related stakeholders
- Obtain the endorsement of elite sport governing bodies/properties, and to utilize the strengths of those organizations to advance the body of knowledge in the sport academy and industry, and to underscore the relevance of its contents, goals, and objectives to practicing sport professionals
- Utilize its accessibility to foster timeliness of complimentary research and increase the prospect of informed policy decisions by practicing sport professionals
- Further disseminate the knowledge contained in JSAS through aggressive indexing/listing/profiling of JSAS in relevant databases and publications, as well as through active media relations initiatives
- University of Michigan Library's Michigan Publishing
- Scholarly Publishing and Academic Resources Coalition (SPARC)
Benjamin D. Goss, Ed.D.
Editor in Chief


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At 15 weeks, Sage's gallumping is slightly more coordinated.
From day one Moe has said, "He walks like a bug." Hence, the birth of his first nickname...Little Bug!
To see The Bug in action, visit these links:
Cute! Frodo sometimes misjudges the steps when he comes in the house--one time he jumped about a foot too early. He is so sweet, but I don't think he is the brightest bulb out there!
Sage's color is getting darker--he will be a handsome boy.
Snippets about the Dogs in my Life: Those in my family, and the Rescues looking for families of their own - plus a bit of miscellaneous on the side!


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140 Character Birthday SMS
A birthday is just the first day of
another 365-day journey around the sun.
Enjoy the trip.
Wisdom doesn't necessarily come with age.
Sometimes age just shows up all by itself.
Here's a Birthday greeting
Especially to show
How much you mean
Although you surely must know
That without a doubt
There's no-one nicer than you
Or anyone dearer
To wish Happy Birthday
Here is the weather forecast for today,
there shall be showers of blessings all over you
and a heavy downpour of God's love all around you.
Happy Birthday !!
I know its ur birthday 2day..
i am sure u'll give me treat in a big hotel..
so i shall talk to u in person there,
coz i dunno to xpress my feelings in SMS
wishing you a day soft as silk.
white as milk.
sweet as honey
& full of money.
may all your dreams come true.


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Ren Jumpsuit Final Sale
$58.00 Regular price
We've never met a jumpsuit we didn't like, and the Ren is no exception. This polished yet sexy silhouette features a deep-v neckline, double-cuffed wide legs, and is made of 100% cotton.
Content: 100% Cotton.
Weight: Light.
Details: Model is wearing a size XS.
More questions regarding fit and size? Email email@example.com for support.
All sale items are final sale.


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Hamptons pillow case set
5 star style
For our Hamptons pillow case set, we have used our signature white organic cotton timeless classic 200 thread count percale weave 'cool & crisp' fabric, which provides the perfect base for a great night's sleep. This collection is finished with an extra note of craftsmanship by adding an immaculate trim of densely stitched cord, which is available in dove grey and navy blue. This collection is ideal for adding a touch of luxury and sophistication to your bed.
This sophisticated decorative cord border completely transforms our Oxford-style pillow cases. The heavily stitched cord border sits at the edge of the pillow itself, with the Oxford-style extra border beyond the edge of the pillow. This is the ultimate in understated luxury and comfort. This collection really does look every bit as luxurious as it feels. It is also affordably priced, giving you the opportunity to be environmentally conscious without breaking the bank.
Hamptons pillow case set:
- Includes 2 pillow cases
- Made from the finest natural 100% Global Organic Textile Standard (GOTS) certified organic cotton
- Oeko-Tex certified – made without the harmful use of chemicals or synthetics
- 200 thread count percale weave cotton
- Cool & crisp feel
- Soft and breathable, with an even matte finish
- Cord detail available in two colours: dove grey and navy blue
- It becomes softer with every wash – it simply improves with age
- Machine washable
- Very durable
- This one is at its hotel-like best after a quick iron
- Packaged in an organic cotton fabric bag, made from offcuts from the production process so no material is wasted
These Hampton pillow cases perfectly match our Hamptons duvet cover set.
Linen Quarter's organic cotton bed linen
- Our bed linen produced to the highest industry, environmental and social standards (GOTS (Global Organic Textile Standard), Oeko-tex (Confidence in Textiles) and ISO certified).
- Our bedding made from 100% organic cotton which is also hypoallergenic, soft on your skin and very durable.
- We trace back to the origin of our cotton, right back to the seed, so you and your family feel confident knowing our products are authentic, pure and chemical free.