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Big Thinkers Discuss Publishing Industry
I've recently started to avidly listen to podcasts and came across an interesting discussion of the publishing industry in an unlikely place, and wanted to share it. Not a huge sports fan myself, a friend turned me on to sports writer Bill Simmons' The B.S. Report.
One particular podcast immediately grabbed my attention: it features statistics wunderkind Nate Silver and best-selling author and social commentator Malcolm Gladwell. Those two alone discussing patio furniture would probably be interesting, but I was delighted to hear the conversation mostly followed the state of the publishing industry.
I encourage you to take a listen here, but following are a few highlights I took from the conversation:
Publishing Power Shift
After becoming a shining star political analyst during the 2012 presidential elections, Silver decided to leave The New York Times, taking his FiveThirtyEight brand with him to ESPN. Silver's dramatic rise to media power-player illustrates a recent trend in publishing, which Jack Shafer aptly analyzes in his piece, Journalism's new Marquee Brothers. Simmons, Gladwell, and Silver go on to discuss how Silver's move signifies the shift in power from publishing organizations to individuals, spurred in part by metrics now available on who drives value and who doesn't.
Industry in Decline
What Silver is doing is considered a "new kind of journalism" based on statistical analysis empowered by big data. And he admits that leaving The New York Times was in part because "it's constrained a lot from a business model standpoint."
The conversation then turns fittingly to how an aging industry can respond to new things. The ever-eloquent Gladwell puts it this way: "The paradox of industries in decline is that they get more conservative not less conservative. You'd think the opposite would be true, right? You'd think if everything is crashing around you, you would scramble and be most open to new ideas and most willing to try things. The weird thing is, you look at actual case studies of companies or industries in decline, how often the opposite happens, they almost double down and become more reluctant to change."
Rigid Old School vs. Fluid New School
Gladwell, who worked in newspaper for 10 years, speaks about how rigidly organized newspapers have traditionally been about subject areas. If you write sports you write sports, if you write for politics, that's it and you defend your turf. The web has shot that idea out the window. "The inability of newspapers to adapt to the fluidity of modern thinking and pop culture, I think that's their biggest problem."
The group goes on to discuss media consolidation and fragmentation, Jeff Bezos' purchase of The Washington Post and the hubris with which Silicon Valley often approaches new industries-for better and worse.
Denis Wilson was previously content director for Target Marketing, Publishing Executive, and Book Business, as well as the FUSE Media and BRAND United summits. In this role, he analyzed and reported on the fundamental changes affecting the media and marketing industries and aimed to serve content-driven businesses with practical and strategic insight. As a writer, Denis' work has been published by Fast Company, Rolling Stone, Fortune, and The New York Times.


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subset: commoncrawl


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What Britain's Next Government Could Look Like After May Loses The Majority
LONDON — British Prime Minister Theresa May needed to take 326 seats in Parliament to hold on to the majority, but with most votes counted, the Conservatives were projected to win only 319. An election once expected to lead to an almost certain victory for the incumbent prime minister, who called early elections herself, has turned into a major defeat for the Tories.
Here are some of the coalitions or arrangements that could result. Most scenarios are either unlikely or would be extremely fragile — possibly paving the way for another General Election.
Minority coalition: Labour and Liberal Democrats
The last time the Liberal Democrats entered a coalition with a much bigger party in 2010, it did not end well for them. Being forced into major concessions by the Tories, the Liberal Democrats lost much support among many of their core voters and never quite recovered.
Minority coalition: Labour and Scottish National Party (SNP)
Instead of forming an alliance with the coalition-skeptical Liberal Democrats, Labour could also join forces with the Scottish National Party to topple the Conservative Party.
In May, Scottish National Party leader Nicola Sturgeon said she preferred having Labour leader Jeremy Corbyn as prime minister. Although Sturgeon added that she did not consider Corbyn a credible choice, she told the BBC that in the case of a hung Parliament, "of course we would look to be part of a progressive alliance that pursued progressive policies." Corbyn, however, has rejected any suggestions that his party could form an alliance with the SNP.
Minority coalition: Labour and Scottish National Party and Liberal Democrats
Although it remains an unlikely scenario, it would probably be the preferred choice of many continental Europeans who still hope that Britain will make a U-turn in its decision to leave the E.U. Together, the Labour Party, the SNP and the Liberal Democrats would have 307 seats in Parliament — fewer than May's Tories will have.
What unites members of all three parties is a certain degree of skepticism that the decision to leave the E.U. was the right one. However, as a minority coalition, the three parties would still rely on the support of other, smaller parties.
Minority government with a 'confidence and supply' deal: Labour and 'supply'
To solve that problem, a certain characteristic of Britain's electoral system could offer a solution. A hung Parliament — in which no single party has a majority — does not necessarily mean that a coalition would have to be formed. Instead, the next British prime minister could potentially also rely on a flexible arrangement in which one party sets up a "confidence and supply" deal with several smaller parties, such as the SNP.
Sturgeon suggested in March that she might be willing to agree to a "looser arrangement" with Labour under the framework of "confidence and-supply."
Under that kind of agreement, the smaller parties would not be part of the government but they would guarantee the prime minister their support on matters such as finances or confidence votes. In return, they would be able to hope for governmental concessions on some of their demands.
Such an arrangement would be extremely fragile, however, as the government would have to unite policymakers from various sides of the political spectrum, including liberals and center-leftist Labour voters as well as Scottish independence supporters, since Labour and the SNP combined would not have enough votes for a majority if exit polls turn out to be correct.
Minority government: Conservatives
Theoretically, May could also decide to try to continue to stay in power despite the loss of a majority. The Prime Minister will only be forced to resign if it becomes clear that she will not be able to obtain a majority through a coalition or loose alliances. However, her political strategy in recent months has alienated many of the parties she would have to rely on for parliamentary votes.
The Labour Party considers itself the main alternative to May's conservative vision for Britain, whereas the Liberal Democrats would like to see Britain remain part of the E.U. The SNP remains frustrated by May's earlier announcement not to grant Scotland another independence referendum anytime soon.
One party to watch for, however, is Northern Ireland's Democratic Unionist Party, which has in the past indicated a possible willingness to support the Conservative Party in case of a hung Parliament.
This article was written by Rick Noack from The Washington Post and was legally licensed through the NewsCred publisher network. Please direct all licensing questions to firstname.lastname@example.com.
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" Virtual sports developer Kiron Interactive has secured a new deal to bolster its presence in the African market, with its games to be launched on Asian operator Dafabet's newly-launched Kenya-facing iGaming site. "
The supplier will launch its racing titles, including horse, dog and motor racing for Dafabet's online and retail offerings in the country.
"We're delighted to be working with Kiron and are sure their quality titles will help us stand out in Kenya as we enter the African market for the first time," Dafabet director of regional operations Louis Watts explained.
"Offering something that's both fresh and of the highest quality when entering a new market for the first time is essential and we are sure Kiron's superb titles will do exactly that."
The deal is Kiron's second high-profile client win this year, following an agreement to launch its games for Argentinean lottery and gaming solutions provider Impresora Internacional de Valores SA (IVISA) in March.
"We are always looking to establish strong partnerships in new and exciting regulated territories and that's exactly what we have achieved with Dafabet," Kiron chief executive Steven Spartinos said
"Continuing our growth into the African continent with an established brand such as Dafabet offers an exciting prospect and one which we are sure will yield great result especially in the rapidly developing online and mobile betting space in Africa."
West African Gaming Expo (WAGE) is the first and only technology conference and exhibition in West Africa focusing on animation, video, mobile games and related products.
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A fun educational event consisting of Conference talks, Hackathons, Workshops / tutorials , Exhibition, Esport Competitions, Tournaments, Giveaways, Product launch and brand activation opportunities.
WAGE connects you with both new and existing partners and provides unprecedented exposure to emerging markets. WAGE is where new worlds of the interactive entertainment industry are inspired.
Please note the WAGE conference is open to all attendees
Please note the WAGE conference is open to all attendees
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Looking for a Job in Gaming and Animation, bring your CV and portfolio to WAGE 16 and meet the employers directly.
Listen to Joost Jetten Interntional Business Development Manager at Logitech introduce attendees to Logitech Gaming Devices.
UNITY will be hosting 2 conference sessions. Any one interested in developement or Animation creation should not miss this sessions.
Are you the best FIFA player in the region. Why not come along and take part in WAGE 16 FIFA 17 tournament. Over N100 000 to be won
This is a pane session hosted by Vortex, This panel will include speakers such as Ibrahim Ganiyu, Ayodele Elegba, Somto Ajuluchukwu, Tobechukwu Nwakere, Edu Shola. They are set to Showcase PAPA Ajasco Animated series, Spirit Wars (Mobile PC Fighting Games) and Many more
Come along as Ultima Limited takes us on a journey of how they created the WWTBAM APP. Listen to their story of what they had to do to get it right. Dont miss the chance to take part in the WWTBAM APP tournament and win BIG
Lagos based Indie Game company, launches their first game THRONE OF GODS. Throne of Gods is an epic fighting game based on African mythology.
Are you the best Mortal Kombat player in the region. Why not come along and take part in WAGE 16 Mortal Kombat tournament. Over N100 000 to be won


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Come and visit Plus65furniture to find that affordable and quality mattress you are looking for.
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Back to Journals » International Journal of Nanomedicine » Volume 9 » Issue 1
Polyethylene glycol–polylactic acid nanoparticles modified with cysteine–arginine–glutamic acid–lysine–alanine fibrin-homing peptide for glioblastoma therapy by enhanced retention effect
Authors Wu J, Zhao J, Zhang B, Qian Y, Gao H, Yu Y, Wei Y, Yang Z, Jiang X, Pang Z, Pang Z
Received 13 August 2014
Accepted for publication 22 September 2014
Published 13 November 2014 Volume 2014:9(1) Pages 5261—5271
DOI https://doi.org/10.2147/IJN.S72649
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Prof. Dr. Thomas Webster
Junzhu Wu,1,2,* Jingjing Zhao,1,3,* Bo Zhang,1 Yong Qian,1 Huile Gao,1 Yuan Yu,1 Yan Wei,1 Zhi Yang,1 Xinguo Jiang,1 Zhiqing Pang1
1Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 2School of Pharmacy, Dali University, Xiaguan, 3School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China
*These authors contributed equally to this work
Abstract: For a nanoparticulate drug-delivery system, crucial challenges in brain-glioblastoma therapy are its poor penetration and retention in the glioblastoma parenchyma. As a prevailing component in the extracellular matrix of many solid tumors, fibrin plays a critical role in the maintenance of glioblastoma morphology and glioblastoma cell differentiation and proliferation. We developed a new drug-delivery system by conjugating polyethylene glycol–polylactic acid nanoparticles (NPs) with cysteine–arginine–glutamic acid–lysine–alanine (CREKA; TNPs), a peptide with special affinity for fibrin, to mediate glioblastoma-homing and prolong NP retention at the tumor site. In vitro binding tests indicated that CREKA significantly enhanced specific binding of NPs with fibrin. In vivo fluorescence imaging of glioblastoma-bearing nude mice, ex vivo brain imaging, and glioblastoma distribution demonstrated that TNPs had higher accumulation and longer retention in the glioblastoma site over unmodified NPs. Furthermore, pharmacodynamic results showed that paclitaxel-loaded TNPs significantly prolonged the median survival time of intracranial U87 glioblastoma-bearing nude mice compared with controls, Taxol, and NPs. These findings suggested that TNPs were able to target the glioblastoma and enhance retention, which is a valuable strategy for tumor therapy.
Keywords: CREKA peptide, nanoparticles, retention effect, paclitaxel, glioblastoma
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]


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Negative Press For East Campus Unfair
Negative Press For East Campus Unfair
I am writing to express my concern for the credibility of "MIT's Oldest and Largest Newspaper." In the past few weeks, an obscenely large number of articles have been dedicated to blowing the activities of East Campus way out of proportion. The Tech has printed false information and misquotations.
The most recent article on East Campus ["East Campus Raises Tax to Replenish Dorm Funds," Oct. 29] forgot to mention that the tax was decided on by a house vote. Stephanie A. Jenrette '97, the very capable and intellegent vice president of East Campus, was made to sound like an idiot. The paragraph about past house budgets being left in the open and recycled was a complete fabrication. The raise in tax was simply neccesary, not scandalous.
If The Tech was examining the issue of house tax, why did the article not include information on the policies of other dormitories? Wouldn't a comparison have been more relevant and, must I say, better journalism?
I feel that East Campus issues have been highlighted in The Tech because several of The Tech's editors are East Campus residents. Instead of writing entire articles of half-truths, why don't they attend House Committee meetings and actually participate in East Campus government? Maybe then The Tech will have space for articles about other dormitories.
Donna M. Augustine '97
East Campus President


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Louisville is top team in Midwest Regional
Breaking down the Midwest Regional
Best team: Can a fourth seed be considered the best team in a regional? Louisville made the case after winning 12 of its final 13 games and roughing up Connecticut in the AAC final on Saturday. Senior guard Russ Smith and sophomore forward Montrezl Harrell formed one of the top 1-2 punches in the country. Smith shoots 40 percent from three-point range, while Harrell hit 61 percent of his shots. It doesn't stop with Smith and Harrell. The Cardinals are strong in most areas, particularly in the backcourt and on the wings with Luke Hancock, Chris Jones and Wayne Blackshear providing ample depth. Collectively, Louisville rebounds as well as any team in the country, which compensates for its lack of experienced power players.
Best big man: Kentucky freshman Julius Randle struggled in the Wildcats' 61-60 loss to Florida in the SEC title game Sunday, but don't hold that against him. Randle helped key Kentucky's run to the championship game, averaging 14.5 points and 13.5 rebounds in SEC preliminary round games. Randle didn't finish the season as strong as he began it, but that doesn't mean he won't be a load for Kansas State to deal with.
Best guard/playmaker: Massachusetts senior point guard Chaz Williams means everything to the Minutemen. His scoring (15.8) and playmaking (7.0 ast) has lifted the program to new heights, which includes its first NCAA Tournament appearance since 1998. Williams was at his best against the UMass' top competition, averaging 20.6 points and 7.5 assists in games against tournament teams Saint Joseph's, George Washington, St. Louis, Dayton, VCU, BYU and New Mexico.
Best go-to-guy: Duke freshman forward Jabari Parker has been as consistent as any player in the country. He can score from just about anywhere inside the midcourt line and rebounds as well as any power forward in America. He had 30 points in Duke's win over North Carolina in its season finale and 27 points in a loss to Kansas in November.
Best player you've never heard of: Arizona State's Jahii Carson just might be a victim of East Coast bias. The sophomore point guard is torching opponents to the tune of 18.6 points, 4.5 assists and four rebounds per game. He scored 40 against UNLV and 29 against Cal. Texas will need to slow him down at all cost.
Best bet for an upset: Carson, along with shot-blocking 7-2 senior Jordan Bachynski (11.1 ppg, 8.3 reb, 4.1 blocks) could make Arizona State a nightmare for No. 7 Texas.
Best matchup: N.C. State-Xavier, playing to earn the No. 12 seed in the Midwest Regional, has fight-to-the-finish written all over it.
Best coaching matchup: Xavier's Chris Mack keeps the Musketeers in the NCAA race no matter how lacking in talent they are. Mark Gottfried has led N.C. State to three straight NCA Tournaments, including the Sweet 16 in 2012.


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Tipton St John Primary School retains outstanding status in SIAMS report
PUBLISHED: 18:13 14 November 2017
Tipton St John Primary School has retained its 'outstanding' status in its latest SIAMS school inspection.
A National Society Statutory Inspection of Anglican and Methodist Schools (SIAMS) inspector praised the distinctiveness and effectiveness at the Church of England school.
The report said: "Children appreciate that everyone is unique and should be treated with respect regardless of background. They have a keen sense of fairness and the need to ensure justice both within school and in the wider community."
The school, which is part of the Ottery Valley Federation with Feniton Primary School was praised for its vision bringing the communities together.
Executive headteacher Colin Butler said: "We are very pleased and proud to see that the very strong Christian ethos, which permeates the whole school, has been experienced by the inspector and this has resulted in such an outstanding report.
"The school and the churches work in harmony to provide the pupils with a rock solid Christian base to their lives which will stand them in good stead in the years to come."
The archdeacon of Exeter Christopher Futcher will present the school with an 'outstanding' certificate next week.
If you value what this story gives you, please consider supporting the Sidmouth Herald. Click the link in the orange box above for details.


text:
Attorney General No.
Secretary of State No.
REAPPORTIONMENT. INITIATIVE CONSTITUTIONAL AMENDMENT AND STATUTE. Repeals existing constitutional and statutory provisions. Adds provisions specifying criteria and procedures to reapportion Senate, Assembly, Congressional, and Equalization districts for 1986 elections and after each decennial census. Establishes commission to adopt plans. Commission composed of eight former appellate court justices, who have not previously been representatives from districts reapportioned and meet other criteria, and certain nonvoting members. Voting members selected by lot equally from two lists comprised of justices appointed be governors representing political parties with largest (list 1) and second largest (list 2) registered voters. Plans subject to referendum, Supreme Court review. Summary of estimate by Legislative Analyst and Director of Finance of fiscal impact on state and local governments: For reapportionment for 1986 elections: (1) State costs for the commission are to be no greater than one-half the amount expended by the Legislature for apportionment plans after the 1980 census, adjusted for inflation, and thus would be up to $3.6 million. Relocating local legislative offices resulting from boundary changes will cost from $10,000 to $20,000 per office relocated. The number of offices that will need to be relocated cannot be predicted. (2) Counties will need to develop new precinct maps and election material. This cost cannot be estimated at this time. For reapportionment after each decennial census (1990 and after): As a result of the limitation of appropriations to the commission to no more than one-half of the amount expended by the Legislature for this purpose after the 1980 census, adjusted for inflation, reapportionment costs probably will be less than what they would be under existing law.
George Deukmejian, Governor, State of California, State Capitol, Sacramento, CA 95814
Document Type
Recommended Citation
Reapportionment. California Initiative 344 (1984).


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A TV series on the techno scene in Berlin is coming soon
"Beat" is the new German series of Amazon Video focused on the techno scene in Berlin, coming out on November 9.
The protagonist of the series is Robert Schlag (Jannis Niewöhner), called Beat, manager of one of the many Berlin clubs, who lives his life one party after another.
Thanks to his numerous connections, the police decides to use his knowledge to enlist him as a secret informer. Beat should use his contacts to identify the minds of an illegal organ trade – all against the backdrop of the city's techno scene.
The series will consist of 7 episodes, and will be visible on the platform of Amazon Video.


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I've recently worked with several peptide groups that are trying out flash purification with their peptides for the first time. And it never fails, every single interaction includes the question "what flow rate should I use for these cartridges?"
There is a lot of information available highlighting optimal flow rates for HPLC method development, but very little information for larger particle stationary phases. I personally have used a wide range of flow rates for my peptide purification with differing outcomes. So in today's post I'd like to have a more thorough discussion about mobile phase flow rate and it's impact on your chromatography.
Flow rate can affect resolution, efficiency, and importantly, purification time. Run time becomes a critical consideration when deciding to use flash chromatography as the purification technique. However, faster isn't always better. Fast flow rates reduce the opportunity for a peptide to interact with the stationary phase, potentially decreasing resolution. Too slow of a flow rate though can lead to significant peak broadening due to on-column diffusion.
I took inspiration for this post after several fruitful discussions with my colleague Bob Bickler, who has probably forgotten more about chromatography than I will ever know. Bob had done some nice work evaluating the impact of flow rate for several different sized stationary phase particles using a mixture of small molecules, but we all know peptides have their own ideas when it comes to chromatography.
Before we go too far though, we need to convert the flow rates to linear velocities, Table 1. It is absolutely critical to perform this calculation to enable scaling of the purification. For consistent chromatographic results across a wide range of cartridge sizes, linear velocity must be kept constant.Table 1: Converting flow rate to linear velocity
|cartridge size (grams)
|cartridge length (cm)
|column volume (mL)
|flow rate (mL/min)
|column void time (min)
|linear velocity (cm/min)
I decided to test out three different flow rates. So I injected about 250 µL of my 18A peptide dissolved in DMSO and purified it using a gradient of 20 to 70% MeCN over 10 column volumes. This time though, I ran the gradient at 12, 25, or 50 mL/min, Figure 1.
There are a couple differences between each purification. The first and most obvious is the relatively significant increase in retention observed with the fastest flow rate (retained 138 mL instead of ~129 mL). We would normally expect the peptide to elute earlier with faster flow rates as the it should be carried out of the cartridge more quickly once desorbed from the stationary phase. Although, there is some evidence to suggest that at higher pressures, the mobile phase plays a more active role in the interaction of peptides with the stationary phase, effectively driving the molecules into the pores and forcing the interaction. This could phenomenon could explain why we are seeing the higher retention with the faster flow rate.
The second thing you will notice a decrease in the baseline fluctuations (waviness) with increasing flow rate. The regularity of the fluctuations suggest a systematic problem and in fact what we are observing is cavitation due to mixing of the acetonitrile and water throughout the gradient. Bubbles are formed when these two solvents mix causing pressure fluctuations, which are detected by the UV detector. The cavitation can complicate post-purification fraction analysis, but I'll discuss in the future some alternative ways to alleviate this problem.
If we delve a little deeper into the technical details for column performance, one thing becomes very clear. Increasing the flow rate causes peak broadening, Table 2. The effect is more subtle when comparing the 12 and 25 mL/min purifications, but becomes quite dramatic upon increasing the flow rate to 50 mL/min. Band broadening can lead to decreased resolution and compromised purity, particularly when closely eluting contaminants are involved.Table 2: Comparison of apparent cartridge efficiency using a linear gradient for peptide purification completed with different flow rates.
|Flow rate (mL/min)
|Retention volume (mL)
|Peak width at half max (mL)
|Theoretical plates per column
|Theoretical plates per meter
So the question becomes this: what are you willing to compromise? There are a few parameters you can readily change to improve your separation, including flow rate. Despite the peak broadening, I have achieved very high purity (>95%) for this relatively dirty crude peptide (27% crude purity) using this gradient and 50 mL/min. The purification requires about 6 minutes to complete, including equilibration and washing at the highest flow rate, compared to about 24 minutes for the slowest flow rate.
Which flow rate would you choose?
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text: Flowers and plants are in abundance on the island of Brava. This plant was photographed in Nova Sintra, the pretty main town on the island. Here visitors will find many attractive gardens and parks. The island also has a very attractive, rugged coastline and a mountainous terrain. Brava is often known as the Garden Island.


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Care and Instructions
Place your Honey Pot Wrap over a bowl, or food item, and press the edges down to form a seal. Voila!
Alternatively, with the bags, place your item in the waxed bag, and either pinch or fold down the top edge to make a seal.
Rinse with cool to lukewarm water, and a gentle soap, air dry. Please do not soak in water, or clean in the dishwasher or washing machine. Special note for washing the waxed bags, please dry upside down so any left over water can come out of the top of the bag.
We do not suggest use with raw meat. Make sure food has cooled down before storing in wraps. Not intended for use with heat or microwave.
Your wraps will last a year or longer with proper care - and are biodegradable and compost friendly at the end of their life. Alternatively, they also can be used as a sustainable firestarter.
Custom Patterns
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Commerce is the activity of buying and selling of goods and services, especially on a large scale or quantity. The system includes legal, economic, political, social, cultural and technological systems that are in operation in any country or internationally. Thus, commerce is a system or an environment that affects the business prospects of economies. It can also be defined as a component of business which includes all activities, functions and institutions involved in transferring goods from producers to consumers.
Some commentators trace the origins of commerce to the very start of communication in prehistoric times. Apart from traditional self-sufficiency, trading became a principal facility of prehistoric people, who bartered what they had for goods and services from each other. Historian Peter Watson dates the history of long-distance commerce from circa 150,000 years ago.
In historic times, the introduction of currency as a standardized money, facilitated a wider exchange of goods and services. Numismatists have collections of these monetary tokens, which include coins from some Ancient World large-scale societies, although initial usage involved unmarked lumps of precious metal.
Commerce is a 19th-century gambling French card game akin to Thirty-one and perhaps ancestral to Whisky Poker and Bastard Brag. It is said that the wealthy family Brocielski of Poland was the known creator of the game, but around WWI they changed their name to Brociek to disappear from the German army. It aggregates a variety of games with the same game mechanics. Trade and Barter, the English equivalent, has the same combinations, but a different way of acquiring them. Trentuno, Trent-et-Uno, applies basically to the same method of play, but also has slightly different combinations.
Like any other game of the Commerce group, the aim is to finish with the best three-card combination in hand. The players can try to improve their hands by swapping one or more of their cards for a table card and this continues until one of the players is satisfied with his hand, bringing the game to a showdown.
Commerce is usually played by 3-10 players, although any number can play. The game is played with a complete pack of 52 cards ranking A K Q J T 9 8 7 6 5 4 3 2. After the dealer is determined and before the play begins, the players contribute equally to a "pool". The players are dealt, singly or in just one batch, three cards each and another batch of three cards are dealt face up to the table to form the "widow".
The river Bolbec or Commerce is one of the rivers that flow from the plateau of the southern Pays de Caux in the Seine-Maritime département of Haute-Normandie into the Seine.
The river rises at Bolbec and passes Gruchet-le-Valasse, where its name changes to the Commerce. It then passes through Lillebonne and joins the Seine at Notre-Dame-de-Gravenchon.
The river hosted many watermills that powered machinery to process both cotton and flax. The area became so prosperous it was named the Golden Valley.
Omaha (/ˈoʊməhɑː/ OH-mə-hah) is the largest city in the state of Nebraska, United States, and is the county seat of Douglas County. It is located in the Midwestern United States on the Missouri River, about 10 miles (15 km) north of the mouth of the Platte River. Omaha is the anchor of the Omaha-Council Bluffs metropolitan area, which includes Council Bluffs, Iowa, across the Missouri River from Omaha. According to the 2010 census, Omaha's population was 408,958, making it the nation's 41st-largest city. According to the 2014 Population Estimates, Omaha's population was 446,599. Including its suburbs, Omaha formed the 60th-largest metropolitan area in the United States in 2013 with an estimated population of 895,151 residing in eight counties. The Omaha-Council Bluffs-Fremont, Nebraska-IA Combined Statistical Area is 931,667, according to the U.S. Census Bureau's 2013 estimate. There are nearly 1.3 million residents within a 50-mile (80 km) radius of the city's center, forming the Greater Omaha area.
Omaha is a city in Nebraska, U.S.
Omaha may also refer to:
Omaha (March 24, 1932 – April 24, 1959) was a United States Thoroughbred horse racing champion. In a racing career which lasted from 1934 through 1936, he ran twenty-two times and won nine races. He had his greatest success as a three-year-old in 1935, when he won the Triple Crown. As a four-year-old, he had success running in England, where he narrowly lost the Ascot Gold Cup.
Foaled at Claiborne Farm in Paris, Kentucky, Omaha was a chestnut horse with a white blaze who stood 16.3 hands high. He was the son of 1930 U.S. Triple Crown winner Gallant Fox and the mare Flambino. Omaha was the third horse to ever win the Triple Crown, which he did in 1935. Flambino also produced the Ascot Gold Cup winner Flares and was the sister of La France, the direct female ancestor of many notable thoroughbreds including Danzig Connection, Decidedly, and Johnstown.
The horse was owned by and bred William Woodward, Sr.'s famous Belair Stud in Bowie, Maryland. He was trained by Sunny Jim Fitzsimmons, who also trained Omaha's sire to the Triple Crown. As a yearling, Omaha was leggy and awkward-looking but a favorite of Woodward, who reportedly considered sending the horse to England to be trained for the Epsom Derby. In the event, Omaha's move to England was postponed until 1936. He was ridden to his biggest wins by Canadian jockey Smokey Saunders.


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'Mad About You' And The Memory Of The Perfect Relationship Sitcom
There was a time, long ago, when I swore to a friend that Mad About You was the perfect relationship sitcom. Not the single best or the single funniest, just a perfect specimen. I can't remember why that was, precisely, except for one thing that seems pretty important in retrospect: it made me laugh, and consistently. That's usually enough.
The fourth season came out on DVD yesterday, but it's been more than three years since the release of Season 3, which leads me to believe that somebody somewhere stopped caring about the show right about this point. That strikes me as odd, because that time long ago when I claimed Mad About You was perfect? Was Season 4. That was the moment.
The quality of the show would get wobbly in about a year; once baby Mabel became a concrete entity, rather than a vague idea that existed as a single possibility among many in some nebulous future, the tone turned brittle and, worse, the focus shifted exclusively and irrevocably from the couple to the child. In short, it became a different show.
But that just makes Season 4 all the more worth treasuring, the last sustained run of episodes about Paul and Jamie purely as a married couple. It's easy to forget now (and was easy to take for granted back then) what excellent chemistry Paul Reiser and Helen Hunt had together, which shines through in the smallest interactions between them. They play. They bicker. They plot. They have fun. More than anything, as both characters and actors, they're a team.
And that holds true for the season finale, a two-part episode that features one of the most genuinely heartwrenching sustained arguments I've ever seen on television, and certainly within the confines of a sitcom. Awful things are said, exasperated comments are misconstrued, mundane tangents quietly introduced and then dropped, and still they keep on. Paul and Jamie occasionally raise their voices, but most of the time, they're just desperate and frustrated that there are no simple sitcom answers available.
They are, in fact, even fighting as a team, both of them more or less on the same side as they try to figure out what went wrong and how to fix it. That fix both comes out of nowhere and rings remarkably true. And then the season ends on a quick but overpowering moment of joy that has stuck with me for 15 years.
What was interesting about revisiting these episodes after a decade and a half was realizing that about 99 percent of everything that I remember and love about the show is contained in this season. That includes characters, like Hank Azaria's Nat the dog walker and Alan Ruck's Lance Brockwell. Plotlines, such as Paul's ill-fated nature documentary Weed (about a weed). Individual, almost microscopic-level jokes, like Cousin Ira grabbing a fake name from his pen and insisting that he was Ira Unibal (and Portuguese). I even remember correctly predicting an old woman's third appearance in a scene in episode 20 ("The Weed") not long after reading a book on comedy that introduced me to the rule of threes.
Unfortunately, there's also a lot that seems, for lack of a better word, sitcommy. The cute TV dog did plenty of Cute TV Dog Tricks. All of the medical professionals -- and there were several in this season where the Buchmans' struggle for conception was a running, though not all-encompassing, thread -- are overserious and judgemental (which seems odd, in that I would think that a humorless fertility doctor is in the wrong line of work). Pretty much everybody contains a degree of caricature.
Everybody, that is, except for Paul and Jamie. Hunt walked away with an armful of Emmys, at least some of which were well-deserved, but it's hard to look at how delicately attuned Reiser was to his TV wife and not think that he deserved them just as much. The two of them, together, were a marvel to witness. I once thought that Mad About You was the perfect relationship sitcom. Watching Season 4 again after all these years, I realized that the sitcom might not be perfect. But the relationship came awfully close.


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Welcome to Day 2 of being vegan! So far things are going quite well, if I do say so myself… but it is only day 2 haha!! Transitioning to a plant based diet can be overwhelming, especially if you don't have close friends and family that are already committed to that type of lifestyle. Personally, meat and dairy are a big part of my everyday diet. Most meals are formed around whatever my meat choice is for the day. When we decided to try being vegan this month, I must admit I had some concerns. What types of meals will I be eating? (Please not just salads.) Will I be able to stay full and satisfied? What about when I don't have a bunch of time to cook? I respected it for the lifestyle change that it is and wasn't exactly sure where to start or how to adjust my life around it. I figured many of you would have similar concerns and struggles, so I decided to share three vegan bloggers/YouTubers that I've found to be a good starting resource. I decided to find black female vegans in hopes that they would understand my lifestyle and be able to explain vegan life "for the culture". (Click the photos t0 view these ladies' websites and recipes!!)
Sweet Potato Soul is a blog and youtube channel by vegan chef Jenne Claiborne. Her website offers tons of free soulful vegan recipes! She also published her first cookbook, Sweet Potato Soul, this February! The SWP YouTube channel is jam packed with all things vegan. From general lifestyle type videos, to cheap meals, to meal prepping, this channel is DEFINITELY an amazing resource to help you see how easy and versatile vegan life can be. I always thought being vegan would be expensive, so the cheap meals and grocery shopping videos were eye opening for me! Go show her some love! Hopefully her website and videos will answer some questions you may have about vegan life!
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The Chic is Natural is another blog/YouTube channel that has some great vegan recipes. In addition to the vegan recipes, the site covers lifestyle, beauty and fashion. Her YouTube channel has a similar spread of topics: let's eat, natural hair, makeup, fashion/lookbooks and more. My favorite thing about The Chic is Natural has to be her "what I ate today" videos. They're pretty short and jam packed with all of the food that she ate that day. They're essentially 3-4 mini recipe videos all put into one. It's nice to be able to get three different meal ideas in 5-6 minutes! I'm all about efficiency!
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Last, but not least, there's Rachel Ama! She is another vegan blogger/YouTuber! "If you love food, travel and beauty with a vegan twist then you are in the right place!" Rachel offers DIY hair care tips and product reviews, vegan recipes and food reviews, info on cruelty-free makeup/skincare and travel! Her YouTube channel focuses mostly on vegan recipes (including introducing vegan food to non-vegans) and a bit about her fitness journey. Her videos are easy to follow, have easy to find ingredients and the food looks great! I also love her accent! Lol
I hope you will find these three ladies to be helpful resources if you're joining us on this vegan journey! Whether it be for this month or for a lifetime, trying a new lifestyle will surely give you more insight to the lives of others and a new level to connect!! Comment below and let us know if you have any other favorite vegan bloggers/YouTubers!! We're gonna need all the help and inspiration we can get!!
Indy Hip Chic is a lifestyle blog following the amazingly awesome lives of 4 Indy natives. Originally created to be a creative outlet and place to try new things we thought why not share this experience??? And with that Indy Hip Chic was born. From cosplay to vegan recipes we cover a little bit of everything while showing off the place we call home.


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In the days leading up to Glen Deaton's emergency trip from Trumann to the University of Arkansas for Medical Sciences (UAMS), large veins that drain blood from his brain were clotting.
Confusion, nausea, vomiting and blurred vision were among his symptoms. An MRI revealed cerebral venous sinus thrombosis a type of stroke caused by a clot that in Deaton's case ran from the top of his head nearly to his neck. With the blood flow stopped like water in a clogged drain, tremendous pressure was on Deaton's brain, resulting in the stroke and hemorrhage despite a shunt to relieve the pressure. He had a seizure, became unresponsive and had to be put on a ventilator.
Salah Keyrouz, M.D., a UAMS stroke neurologist and Deaton's physician, described it as the worst case he had ever seen. "I didn't think he was going to make it," he said
Keyrouz called on Eren Erdem, M.D., and Mollie Atherton, M.D., both UAMS interventional neuroradiologists. Atherton and Erdem used a balloon catheter to try to break up the clot, but it was unsuccessful. Next they used the catheter to apply a powerful blood thinner, t-PA, right at the site of the clogged vein. That didn't work either.
Their breakthrough came when they next tried a new catheter machine that was acquired only months before by UAMS as part of a $2 million National Institutes of Health grant for research of new stroke treatments. Called EKOS, the device could deliver the t-PA at the site of the clot and vibrate it with ultrasound to help the blood thinner penetrate the clot.
As with the previous catheter attempts, Atherton and Erdem threaded the tiny device into a leg vein and all the way into the brain.
"I was amazed at how quickly it dissolved the clot," Atherton said. "We were able to restore blood flow within about an hour."
The next day Deaton, 42, awoke from his coma, and a few months later, he was nearly back to full strength.
It was the first time for the EKOS machine to be used on Deaton's type of stroke, and Erdem and Atherton have been invited to present the case to the Cardiovascular and Interventional Radiological Society of Europe at its September meeting in Portugal.
Keyrouz recalled his amazement with Deaton's recovery when he happened to bump into Deaton visiting a friend at UAMS about three months before his follow-up visit. "I couldn't believe he was doing that well."
During the more recent office visit with Keyrouz, Deaton said he didn't remember much about his time at UAMS or realize the extent of the treatments.
"We honestly didn't think you were going to make it," Keyrouz told him. "You had one of the most severe cases of blood clots in the veins in your brain."
Deaton was admitted to UAMS on Jan. 9 and went home on Feb. 5. He said he hadn't been aware of all that had gone into his treatment until his visit with Keyrouz.
"I'm a little beside myself, thinking about how bad it was," Deaton said. "I'm glad I came to UAMS, and I'm glad they could help."
William Culp, M.D., who is leading the NIH-funded research of new stroke therapies at UAMS, said while the FDA-approved EKOS machine was acquired for his research, he is glad to share it to treat patients when needed.
Culp credited the machine as well as UAMS' ability to provide a multidisciplinary approach to the successful treatment of Deaton's life-threatening condition.
"This is a case where research helped the clinical care, and it took a team to actually make this happen," Culp said. "And this does represent an exceptional level of skill Dr. Erdem and Dr. Atherton are very good."
UAMS is the state's only comprehensive academic health center, with five colleges, a graduate school, a new 540,000-square-foot hospital, six centers of excellence and a statewide network of regional centers. UAMS has 2,652 students and 733 medical residents. Its centers of excellence include the Winthrop P. Rockefeller Cancer Institute, the Jackson T. Stephens Spine & Neurosciences Institute, the Myeloma Institute for Research and Therapy, the Harvey & Bernice Jones Eye Institute, the Psychiatric Research Institute and the Donald W. Reynolds Institute on Aging. It is the state's largest public employers with more than 10,000 employees, including nearly 1,150 physicians who provide medical care to patients at UAMS, Arkansas Children's Hospital, the VA Medical Center and UAMS' Area Health Education Centers throughout the state.
Source: University of Arkansas for Medical Sciences
In the days leading up to Glen Deaton's emergency trip from Trumann to the University of Arkansas for Medical Sciences (UAMS), large veins that drain blood from his brain were clotting.


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Tuesday, July 19, 2011
From Chad Seybt
Well, again I have turned out to be the weakest link. Those four days of illness in Kathmandu made me weaker than I realized. On the 5 hour wike we were supposed to take up and down two days ago, I only made it about 10% up. The group was very gracious in cheering me on when I got to the "resting spot." But in just that little climb, I started seeing spots and my heart was pounding in my chest and my head was just throbbing. I had a really bad headache in the back of my head and the "spots" didn't go away until about a half an hour. I discussed with Todd and Raju what the rest of the hike would be like even with someone else carrying my bag, but ultimately came to the VERY difficult conclusion of staying back in Dhading. I was literally heartbroken because this was our last hike of the trip, and I had yet to make a hike. With a heavy heart and a head hung low, I made the climb back down to Dhading. But I was to have great company in the pastor's son from Maidi, Pramod. After reaching Dhading and fueling up on food he and I spent a good two hours teaching each other Nepali and English. He was very interested in getting my email address, and I hope we can stay in contact with each other. Being alone has allowed me to make some very special friendships with other Nepali Christians that the group just gets to meet. For that I am ever so thankful to the Lord. I am very much excited and looking forward to preaching in Kathmandu on Saturday and also our pastoral training seminar. I pray that the Lord will give us good health and safe travel and continue to lift my spirits. "This is the day the Lord has made I will rejoice and be glad in it!"
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Football Solutions Women's EURO - Sabrina ViguierPosted at 06:50h, 08 November
Jonny Evans has signed a new four-year contract with Manchester United as Sir Alex Ferguson plans for the future. Evans has made huge progress in the last two seasons. Manchester United defender Jonny Evans signs four-year contract to stay at Old Trafford


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If you ask yourself why you end up with these people, the answer is because you are drawing them to yourself unconsciously and allowing them to take what is important to you and trample on it.
You are actually the common denominator in all of these relationships, and if you don't change the signal you are projecting, you will continue to draw these people to you and repeat your past cycles.
The only solution is to be healed of what is causing you to send out your signals that draw selfish people to you who do not respect you or pour back into your life.
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You can download the Kindle version immediately (you don't have to have a Kindle, just download the Kindle app to your phone or tablet or computer) and just write your answers in a journal.
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Take the Codependency Quiz...
Do you have trouble saying "no" to people?
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If you will be open to learning new things and admitting old things, and are willing to apply yourself to the homework, you will become healthier, will see a huge change in the way you see and feel about yourself, and your relationships will become more healthy as well.
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text: Products8 Must-Haves to Pack for a Snowy Winter Babymoon by Katherine Louie Updated: July 20, 2018 In This Article Skin Hydrator : Simple Water Boost Hydrating Gel Cream Cozy Chic : Ingrid & Isabel Cowl Neck Maternity Sweater Warm and Supported Belly : Maternity Bellaband Support Belt Comfy Denim : HUE Essential Denim Leggings Head Warmer : Madewell Skrallan Cuffed Wool Beanie Toasty Toes : Globalwin Waterproof Snow Boots Snap Happy : Leica Sofort Instant Camera Pack It All In : Away Medium Luggage Whether you're expecting your first child or your third, taking a babymoon is a great way to relax and reconnect before your new baby arrives. If you're planning your babymoon for the winter months (think cozy cabins, hot cocoa and oversized sweaters) there are plenty of dreamy escapes that parents-to-be will enjoy even as the temperature drops. But before you leave for your trip, be sure to pack items that will keep you warm, cozy and protected.Read on for our top items to pack for a snowy babymoon.Just so you know, What to Expect may earn commissions from shopping links. Why trust our product recommendations?Skin HydratorSimple Water Boost Hydrating Gel Cream Available at Target starting at $6See NowWhy We Love ItIf you're traveling during the winter, your skin may be prone to dryness. The cold air will cause the moisture in your skin to evaporate quickly, and overheated indoor air may compound the problem. To keep your skin supple, moisturize with a hydrating gel cream. Simple's ultra-light and refreshing formula is made with skin-loving ingredients, essential minerals and plant extract. What's not included? Artificial colors, artificial fragrance and parabens or phthalates — which may be dangerous to a developing baby. And, to enhance the effectiveness of this cream, don't forget to drink enough water. 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This page has been compiled from extracts of the book Hekate Liminal Rites by Sorita d'Este and David Rankine (with permission) and blogs entries written by Sorita in 2011 (no longer available).
The Rite of Her Sacred Fires include the use of the "Ephesian Letters" – and a number of people have asked about this – so I decided to put together the following for those unfamiliar with its use, I hope that it explains its inclusion in the rite.
"Askei Kataskei Eron Oreon Ior Mega Samnyer Baui Phobantia Semne."
One of the oldest and most significant sets of voces magicae (a term used for magical words of unknown meaning and origin) was the Ephesian Letters or Characters, a group of six words. These words were askion, kataskion, lix, tetrax, damnameneus and aision(or aisia). We cannot be absolutely certain whether the Ephesian Letters were specifically connected with Hekate, though from the evidence it does seem likely. Their first known appearance was in a Mycenaean inscription from the fifth century BCE.
The Ephesian Letters occur a number of times in the Greek Magical Papyri in charms which call on Hekate. Thus the first two of the Ephesian Letters were used in a Hekate charm associated with initiation (PGM LXX.12) as part of a string of voces magicae, being:
"Askei Kataskei Eron Oreon Ior Mega Samnyer Baui Phobantia Semne."
The fifth word, damnameneia, was used in the Bear Charm, which included reference to Hekate as Brimo (PGM VII.686-702). A second-third century CE lead defixione tablet to Hekate as torch bearer of the crossroads also uses this word repeatedly (SM 49).
An early fragmentary protective charm on a lead tablet from Phalasarna on Crete included the Ephesian Letters with phrases indicative of Hekate like 'She-wolf'. It is also interesting to note that they are called the Orphic Formula in the Greek Magical Papyri (PGM VII.451). Considering the connections between Hekate and the Orphic Mysteries, this is another hint which suggests a specific ritual connection with Hekate and these words.
The Ephesian Letters were also referred to by the Greek poet Anaxilas in his lost fourth century BCE play The Harp Maker, when he wrote "[unnamed person] carries around marvellous Ephesian letters in sewn pouches." Various qualities were attributed to the Ephesian Letters, including endowing the wearer with great power (particularly wrestlers as described in Eustathius, Photius and the Suda) and protecting newly married couples (mentioned by Menander, fragment 371).
It should also be noted that when Plutarch commented on the powers of the Ephesian Letters (Moralia 706E), he referred to daimones, who were specifically under the rule of Hekate:
"For just as sorcerers advise those possessed by daimones to recite and name over to themselves the Ephesian letters."
The Christian theologian Clement of Alexandria, who was well known for being the teacher of the theologian Origen, recorded suggested meanings for the Ephesian Letters in his work Stromata (Miscellanies) in the early third century CE:
"Androkydes the Pythagorean, indeed, says that the so-called Ephesian letters, which were well-known among many, were of the order of symbols. And he said that Askion is darkness, for this has no shadow; and Kataskion is light, since it casts a shadow with its rays; and Lix is the earth, according to the ancient name; and Tetrax is the year, according to the seasons; and Damnameneus is the sun, the tamer; and Aisia is the true word. And truly the symbol signifies that the divine things have been set in order: darkness to light, the sun to the year, the earth to every kind of genesis of nature."
(Based on Voces Magicae, ch. 5 of Hekate Liminal Rites, d'Este & Rankine, 2009:65-69)
Returning to the words used in the Rite of Her Sacred Fires, "Askei Kataskei Eron Oreon Ior Mega Samnyer Baui Phobantia Semne" – as voces magicae we cannot know for certain what they meant when they were used, but we can draw together likely speculations. From Clement of Alexandria, we can see that the phrase starts with Askei Kataskei which could mean 'darkness, light'. Mega in Greek means 'great', and it has been suggested that Baui may refer to the barking of a dog (Betz 1996:297, fn.7). All of these speculations hint at Hekate – both darkness and light, greatness, and dogs. As such it is possible that this phrase was a coded sequence which called on Hekate's powers.
Today the Ephesian letters continue to be used in rites honouring Hekate, I have been using it for many years in a form of chanting honouring Hekate, much like the pujas found in spiritual traditions such as Hinduism. It is being used to honour Her, but also to protect and empower magical rites.
LINK: http://hekatecovenant.com/rite-of-her-sacred-fires/useful-info/ephe...


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(exhaling) OK ladies and gentleman.
Right now I am compiling a list of my grail pens particularly from Japan and would really appreciate your input.
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