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There are a handful of major science institutions around the world that keep track of the Earth's temperature. They all clearly show that the world's temperature has risen in the past few decades. One of those institutions is NASA.
NASA's Goddard Institute for Space Science Studies (GISS) is located in New York City. Recently, they did a complete assessment of their temperature data, called GISTEMP, or GISS surface Temperature Analysis.
The GISTEMP is one of our most direct benchmarks for tracking the Earth's temperature. It goes back over 100 years, to the 1880s.
Every year, NASA partners with the NOAA (National Oceanic and Atmospheric Administration) to update the global temperature. They use temperature data dating back to 1880 from land and sea surface measurements, combined with more modern measurements from over 6,300 weather stations research stations, and ships and weather buoys around the world.
Using all this data, the pair of organizations concluded that 2018 was the fourth-warmest year on record, and that 2016 was the warmest.
In this new study, NASA scientists analyzed the GISTEMP data to see if past predictions of rising temperatures were accurate. They needed to know that any uncertainty within their data was correctly accounted for.
The goal was to make sure that the models they use are robust enough to rely on in the future. The answer: Yes they are. Within 1/20th a degree Celsius. Kudos.
"Uncertainty is important to understand because we know that in the real world we don't know everything perfectly," said Gavin Schmidt, director of GISS and a co-author on the study.
"All science is based on knowing the limitations of the numbers that you come up with, and those uncertainties can determine whether what you're seeing is a shift or a change that is actually important."
This is scientific rigour at its finest. To a climate change denier, it may seem like ammo. But the reverse is true. NASA is determined to understand their GISTEMP data to the best of their capability, and they acknowledge, like all scientists should, any weakness in their own data and then seek to quantify it.
The NASA analysis ferreted out four sources of uncertainty, however miniscule, in the GISTEMP data.
The first is how temperature measurement changed over time, and it contributes the most uncertainty. Second was weather station coverage. You can't have a weather station at every point on Earth, so you have to interpolate the data. That interpolation is the third largest source of uncertainty, though it's contribution to uncertainty was tiny.


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The dangerous gang MS-13 is made up of criminals who pretend to be children to exploit weaknesses in our immigration laws.
Apparently, MS-13 has started threatening American law enforcement.
Frankly, it is old news that MS-13 has been exploiting our laws regarding minors in order to get past immigration restrictions. It has been going on during the Obama Presidency though I don't remember hearing much about it from the Administration. Hopefully, under President Trump, law enforcement will actually remove MS-13 from American society.
The Washington Times reports, "MS-13 members game U.S. immigration system by claiming they're underage."
Trending: The Conservative Answer to Reforming the Criminal Justice Sysytem
MS-13 is paying smugglers to coach gang members on how to game the U.S. immigration system, teaching underage members to claim UAC status — and telling those over 18 to lie and claim they are underage — to try to gain quick, easy access to the U.S., government officials said Thursday.
Rep. Peter T. King, a New York Republican, said his district is such a hotbed of MS-13 activity that authorities are "right now digging for bodies within a mile of my house." He said some families are forced to facilitate gang members' arrivals and are pressured by gangs to become sponsors and claim the children when they arrive.
Homeland Security Secretary Kirstjen Nielsen confirmed the pipeline.
"They recruit young children, they train them how to be smuggled across our border, how to then join up with gang members in the United States," she told Congress.
The government this week detailed such a case from this month in Arizona, where Border Patrol agents nabbed an 18-year-old from El Salvador. He first claimed to be underage to try to claim UAC status. Under questioning, he acknowledged he was an adult and was part of MS-13 — though he insisted he was trying to leave the gang.
Unaccompanied alien children — those who arrive at the U.S. border without their parents — are among the trickiest populations of illegal immigrants.
They began to surge toward the U.S. in 2012 and crested in 2014, overwhelming an Obama administration that was ill-equipped to handle them. In addition to gangs, some UAC were turned over to criminals, who forced them into labor or otherwise abused them.
More than five years into the crisis, the UAC numbers are once again rising — and the administration is still struggling to get a grip on matters, as officials made clear in hearings Thursday on both sides of the Capitol.
The views expressed in this opinion article are solely those of their author and are not necessarily either shared or endorsed by EagleRising.com

subset: commoncrawl


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Acupuncture and pregnancy
Can acupuncture help with pregnancy? That can be considered as two different questions.
Either, it is questioning if acupuncture can increase your chances of getting pregnant? Or, it is asking if acupuncture can help reduce side-effects during pregnancy?
We explore both questions and see what the evidence suggests.


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We took our daughter to Pellissippi State Community College for the annual hot air balloon ride. Good times were had by all–except the daughter.
We took our daughter to Pellissippi State Community College for the annual hot air balloon ride. Good times were had by all–except the daughter.
There are some great before and after images of Katrina. If you have a few minutes check it out… NOAA USGS Google EARTH Google Maps
August 29, 2005 September 22, 2005
After calling for Mike Brown's resignation 10 days ago, Mike Brown finally got the message. Another service brought to you by e-community.
I don't want to strike fear in anyone. MSNBC, CNN, and FoxNews are such experts at distributing desperation that I would not want to diminish their impact. I just have one question: What usually happens when we travel? When I travel I usually get the sniffles–at a minimum and sometimes I get far sicker. As far as I understand this phenomenon, our immune systems build up antibodies to local environmental viruses and bacteria. When we are exposed to foreign strains of disease, we are ill-prepared to deal with those strains. New Orleans is forcing every citizen to evacuate the city. As we have seen, the city is one of the poorest cities in the nation. Obviously, survival and not healthcare has been a priority among many of the citizens. So, when half of a million people are distributed across the United States, they seem to be simultaneously planting their disease…
As I have watched obsessed over Katrina's devastation this last week, through my media center computer, I have really thought about the hobbies that I have in my life. The winds and the water came into these people's lives and wiped away all investments that they had. Months and years of acquiring "things" was wiped away in the matter of hours, in turn, the victims will get a piece of paper–at best. While watching the finely tuned news channels, I realize that countless days and hours went into creating my truly all-in-one media center. I watch all my movies, listen to all my MP3s, watch and record live TV, download dynamic content, and even read blogs on this media masterpiece, but it did not come cheap. I paid 2 hours of reading to my daughter, 1 hour of teaching her how to ride her bike, 30 minutes of watching her…


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February 02, 2011
After campaigning in support of gaming expansion, Governor Mark Dayton has been slowing down his support. Stating that amount of time needed in this session is too short to create the new necessary law that would include gaming revenue in the budget for this year.
When the governor was busy campaigning, he was in support of a state run casino. That support was given for a casino near the Mall of America, or the Minneapolis-St. Paul International Airport.
With a deadline approaching, other law makers are not as quick to give support to an expanded gaming bill. The governor has proposed a state budget that does not include gaming revenue.
Previously, lawmakers had supported the idea of building a casino. A popular idea was using part of the revenues to build a new stadium for the Minnesota Vikings. It is possible that the Viking ownership may decide to move the team if they cannot build new stadium.
Minnesota lawmakers have two weeks to work on a state budget that includes a $6.2 billion deficit.
Return to Minnesota Casinos.
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Disclaimer: All images are copyright to their respective owners and are used by 500 Nations for informational purposes only.
500 Nations is an independent directory and information service free of any gaming operator's control and not affiliated with any casino.
Warning: You must ensure you meet all age and other regulatory requirements before entering a casino or placing a wager. There are hundreds of jurisdictions in the world with Internet access and hundreds of different games and gambling opportunities available on the Internet. Do not assume that Internet gaming sites are in compliance with the rules and regulations of every jurisdiction from which they accept players. YOU are responsible for determining if it is legal for YOU to play any particular game or place any particular wager under the laws of the jurisdiction where you are located.


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Pronunciation: \ī-ˈkä-nə-ˌkla-zəm\
Function: Noun
1. The deliberate destruction of cultural and religious icons and other symbols or monuments, usually for religious or political motives, eventually affecting the architectural trend.
2. The doctrine, practice, or attitude of an iconoclast
(uday-goswam, 26:11:07)
Tag this site in del.icio.us.
page revision: 7, last edited: 09 Dec 2007 16:58


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By Cody Casares, Photo Editor
April 20, 2016
Financial aid disbursements will be easier for students starting this summer.
The college has partnered with Blackboard, an educational service program, to streamline the financial aid services for students.
"The service ...
The Advocate
The Student Voice Of Contra Costa College, San Pablo, Calif.
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The question is answered, right answer was accepted
im wondering whats the difference between:
var myVar : Vector3 = new Vector3(1,1,1);
var myVar : Vector3 = Vector3(1,1,1);
-or using them in Update function: function Update () { myVar = new Vector3(2,2,2); } -and function Update () { myVar = Vector3(2,2,2); }
So can someone explain the difference for me? I mean whats the difference with "new" keyword and without it?
Answer by FlaSh-G
Jun 23, 2017 at 05:37 PM
Both works in UnityScript because UnityScript is heavily based on JavaScript, which isn't an object oriented language by heart, but rather "kinda supports it" also. UnityScript is trying to mimic JavaScript every now and then, which is the season for the existence of the print function, which is the only lowercase function in all of Unity.
This is also why it supports using the new keyword or omitting it, because that's somehow similar to the weird situation with the keyword in JavaScript land.
Long story short: For all I know, it doesn't make a difference if you use it or not, just like it doesn't make a difference whether you use print or Debug.Log.
The best place to ask and answer questions about development with Unity.
To help users navigate the site we have posted a site navigation guide.
If you are a new user to Unity Answers, check out our FAQ for more information.
Make sure to check out our Knowledge Base for commonly asked Unity questions.
If you are a moderator, see our Moderator Guidelines page.
We are making improvements to UA, see the list of changes.
Answers and Comments
68 People are following this question.
What are Keywords and How do I utilise them?
How to make keywords per material works properly (not in Editor)
Find, access and change a keyword property of Material: HOW?
Upload level details, variable always null.
You are trying to create a MonoBehaviour using the 'new' keyword. This is not allowed.


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- Assured$200
- Entries41
- Creatives21
- Feedback/StatsGood
Tell us what you need
What is the exact name you would like in your logo?
Window World
What is your industry?
Real Estate and Construction
What are the top 3 things you would like to communicate through your logo?
Quality, initials WW in there, and a globe of sorts
What logo styles do you like (image + text, image only, text only, etc.)
image + text with few colours like red, black and white
Do you have any other info or links you want to share?
business name is window world and we sell windows and doors
No Files Added


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Members can access SVABO's online resource library.
Member Forums
There is a new tool available to communicate with other SVABO members at the SVABO Forums.
SVABO Communications
Anyone can sign up for SVABO Notices. If you do not have an account in our system, you will be asked to create one. If you already have a login, you can update your preferences by logging in.
Join SVABO
For over fifty years, this organization has been a leader in Code Development and Educational offerings. With ICBO having merged into ICC, the organization has an opportunity to focus on the needs of our members and consumers.
We provide our members, associates and the general public with the latest developments in building safety from local, state, national, and international perspectives.
As you are aware, there have been significant challenges to our profession ranging from the uncertainty of which codes we will enforce to the constant flow of new regulations we are responsible for. With the new challenges we face, the Association has been undergoing changes. This last year has seen our organization change by including new and varied meeting formats, a refocusing of our efforts in Code Review and code development to our continued quality educational offerings.
There are four types of SVABO memberships:
Basic – $65 (receive minutes & membership rates for education)
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Student – $20 (In recognized program and not employed in the industry)
To become a SVABO member, complete our Membership Application form.


text:
IObit Advanced SystemCare 12.5 PRO (v18.104.22.1685) DC 13.08.2019 Multilingual
Advanced SystemCare provides automated and all-in-one PC care service with Malware Removal, Registry Fix, Privacy Protection, Performance Tune-up, and System Cleaning capabilities. It also creates superior and safer online experience with the latest Surfing Protection and Internet Boost technology, ensuring you top online security and maximum PC performance.
What's New in Advanced SystemCare 12.5:
+ Win Fix newly supports fixing the issue that Microsoft Edge icon disappears from desktop.
+ Privacy Sweep newly supports sweeping the privacy data of the latest Chrome 76.0, Firefox 67.0, Adobe Flash Player 32.0, and Notepad++ 7.7.
+ Junk File Clean newly supports cleaning the latest Dropbox 74.4 junk files and more installed driver packages.
+ Software Updater newly supports the updates of the latest Chrome 76.0, Firefox 67.0, etc.
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+ Expanded the database of Spyware Removal and Real-time Protector to remove more threats.
+ Updated multiple languages.
+ Fixed all known bugs.
Operating System:


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July 1st through midnight July 6th only
Planning to stick close to home this weekend? Here's your chance to purchase the paperback edition of Since You Went Away, Part One: Winter for only $4.99. Normally $7.95 on Amazon (and $14.95 in bookstores), this is a super duper extra special deal.
What better way to celebrate the July 4th holiday than immersing yourself in this unputdownable story of a modern-day military family? Featuring a deeply human cast of characters and written in McCarthy's trademark epistolary style, the book is easy to read in small chunks—but don't be surprised if you find yourself reading late into the night to find out what happens next in the lives of the fictional Mahoney family.
Set against the backdrop of the Iraq war in the year 2008, Since You Went Away portrays in intimate detail the effects of a distant war on the families and returning veterans at home. At once poignant and darkly funny, it is a fly-on-the-wall account of the innermost workings of a military family—their fears and hopes, their struggles and disappointments, their unexpected moments of joy and comfort and laughter.
"Touching, funny, thought-provoking, heartwarming, engrossing, and humorous" are just a few of the words readers use to describe McCarthy's latest series. And now you can join in the fun for less than the cost of a venti iced matcha latte.
This offer applies to the paperback edition of Part One, this weekend only, exclusively through Amazon.
Click here to order the paperback.
about the author:
Nan McCarthy is the author of the Since You Went Away series, Chat, Connect, & Crash, Live 'Til I Die, and Quark Design. A former magazine editor & tech journalist, Nan founded Rainwater Press in 1992 and began selling her books online in 1995. Nan and her husband, a veteran who served 29 years in the Marine Corps, are the proud parents of two adult sons. Nan wrote Since You Went Away after taking a ten-year break from full-time writing to care for the family during her husband's frequent military travels.
Cover design by David High.
Cover art by Larry Jacobsen.
Since You Went Away, Part One: Winter
Nan McCarthy
(Rainwater Press, 2017) 172 pages
Part Two: Spring and Part Three: Summer now available. Part Four: Fall available later this year.


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We submitted a claim for our cocker spaniel after she was admitted for excessent vomiting. I was very happy with how simple it was to make a claim. The people at trupanion stayed in contact with email updates on the progress of the claim. I would have liked to see more things covered, but its a help anyways.
Claim Amount
$500 - $1000
Cocker Spaniel
Age of Pet
1 - 8


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Often called "the cornerstone" of public health, epidemiology is the study of the distribution and determinants of diseases, health conditions, or events among populations and the application of that study to control health problems. By applying the concepts learned in this course to current public health problems and issues, students will understand the practice of epidemiology as it relates to real life and makes for a better appreciation of public health programs and policies. This course explores public health issues like cardiovascular and infectious diseases – both locally and globally – through the lens of epidemiology.
Epidemiology: The Basic Science of Public HealthThe University of North Carolina at Chapel Hill
About this Course
Learner Career Outcomes
Learner Career Outcomes
Offered by
The University of North Carolina at Chapel Hill
The University of North Carolina at Chapel Hill, the nation's first public university, is known around the world for innovative teaching and research. Regularly ranked as the nation's best value for academic quality, UNC has produced the most Rhodes Scholars for the past 25 years among U.S. public research universities.
Syllabus - What you will learn from this course
Course Introduction, History of Epidemiology and Epidemiology Research
This module introduces the history and field of epidemiology.
Understanding Measures of Disease Frequency
This module introduces measures of disease frequency.
Study Designs
This module introduces the following study designs: experimental, cohort, case control, cross-sectional, and ecologic.
Measures of Association
This module introduces measures of association and confidence intervals.
- 5 stars
- 4 stars
- 3 stars
- 2 stars
- 1 star
Very clear teaching strategies from the instructors. Some quizzes though are a little bit hard on my part because of the type of questions and answers. But overall it is a great course to take with.
I just completed my course and I would like to appreciate the tutors for doing a great job, yeah! Also, I recommend Coursera for anyone who wants to experience advancement in knowledge and career.
Very useful and comprehensive information. I warmly recommend this course to all the ones interested in getting a proper understanding of the terms, concepts and designs used in clinical studies.
Interesting, a great introduction in epidemiology and public health. I especially enjoyed the experimental trials design lectures. A good start for someone who wants to have a view in the field.
Frequently Asked Questions
When will I have access to the lectures and assignments?
Access to lectures and assignments depends on your type of enrollment. If you take a course in audit mode, you will be able to see most course materials for free. To access graded assignments and to earn a Certificate, you will need to purchase the Certificate experience, during or after your audit. If you don't see the audit option:
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What will I get if I purchase the Certificate?
When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.
Is financial aid available?
Yes, Coursera provides financial aid to learners who cannot afford the fee. Apply for it by clicking on the Financial Aid link beneath the "Enroll" button on the left. You'll be prompted to complete an application and will be notified if you are approved. Learn more.
Will I earn university credit for completing the Course?
This Course doesn't carry university credit, but some universities may choose to accept Course Certificates for credit. Check with your institution to learn more. Online Degrees and Mastertrack™ Certificates on Coursera provide the opportunity to earn university credit.
More questions? Visit the Learner Help Center.


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07/02/2013 – Thecus® is constantly providing the most updated HDD and SSD on the market to pair with Thecus® NAS. Thecus® has been hard at work keeping its compatibility lists ahead of the market and has added a number of new compatible hard and solid state drives for a number of different NAS.
For models: N8900 / N8900V / N12000V / N16000V / W8900 / W12000 / W16000
- Added Toshiba SSD HG5d : 60GB, 128GB, 256GB, 512GB
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For models: N2200EVO / N4100EVO / N4100PRO
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One Day Biking in Ouirgane from Marrakech
Your One Day Biking in Ouirgane begins driving in the morning from Marrakech, your ride will begin at Ouirgane, where you'll take the south west pass towards the most important village in the region, where vibrant Berber markets are held every week..
Continuing to the village of Marigha, you'll journey offroad between fields of olive trees and through more traditional berber villages, before reaching the spectacular Ouirgane dam with its breathtaking views over the lush colourful landscape.
After this you'll enjoy a Freshly prepared lunch from your tour's own personal chef, you'll continue on an mixed off-road and single track discovering that Moroccan Colorado, where you'll visit a local salt mine and it's beautiful surroundings before continuing back to Marrakech.
Grade : easy- moderate.
Distance: 32 km mountain bike / mixed off road single tracks / ascent 600m & descent 750m
IncludedOne Day Biking in Ouirgane from Marrakech


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It is wednesday, we are halfway through the week and lovely sunny day in Marbella so we want to share with you a wonderful love story that started in Italy and had a happy ending in Spain.
The width of the ocean, a fine sandy beach and two lovebirds who are about to get married, that's all you need for an unforgettable dreamlike wedding!
The Italian couple, Natalie and Max, decided to plan their own elopement and finally get married in a private ceremony at the beautiful Kempinski Hotel Bahia in Estepona at the beginning of spring. We were delighted to be part of this romantic idea the couple had and the honor to organize for them a fantastic wedding.
The wedding was captured by the talented Joseba and Mar Sandoval aka Romance Weddings. They know how to capture the emotions and details.
Natalie's choice for this unique event was a gorgeous gown designed by Claire Pettibone, specially brought for her from America! Liza Mayne, a wonderful hair and make-up artist, brought out Natalie´s sweet facial features so that she looked gorgeous on that day. Natalie decided to complement her fantastic gown with a hairpiece from Oh-anami. She was stunning!
Inspired by the colors of the ocean and the atmosphere of Costa del Sol, our team created an adorable setting for the couple. All flowers and candles décor were provided by Virginia Floristas. Pedro Navarro provided the table linen and the Napoleon II transparent chairs. Our Nostalgic range of glasses and our silver charger plates were perfect for the occasion. Many nice decoration items placed on the sand and a complex cake made by Cake Couture were the visual highlights of the elopement. The scene was just perfect!
Natalie and Max said yes during a private ceremony at the beach conducted by Kurt Kettner-Borough. They both wanted to spend this special moment in their lives with each other and gave us the opportunity to plan the wedding of their dreams by the seaside. It was so exciting!
Once again, we succeed to deliver a dreamlike soiree that the couple will never forget. We managed to create an elopement atmosphere withbrush-strokes of sensuality and romance, as per the couple wishes. What an adorable event!
After the lovely evening, Natalie and Max, started a new life as husband and wife by spending their honeymoon holidays travelling around Spain, adding like this the final touch to an original way of getting married…but sshh it is a secret!


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Byculla zoo to get new animals in 2019
BMC in the final stage for appointing contractors to construct new enclosures
Gear up to welcome a range of new animals, including tigers, an Asiatic lion and zebras, in the city in 2019. According to sources, the civic body is in the final stage for appointing contractors to build enclosures for the new entries at the Veermata Jijabai Bhosale Udyan and Zoo, also known as the Byculla Zoo. More than a year after the previous contract was scrapped, the BMC has issued two tenders worth Rs 120 crore, which has attracted responses from three contractors. According to sources, work on the project is likely to begin after February.
As part of the new tenders, one contractor will responsible for constructing 10 enclosures, while the other will have to make seven. According to zoo authorities, the new fish and animals would be sourced through various exchange programmes with other zoos. Byculla zoo director Sanjay Tripathi said, "We have received a great response for the tenders, which we will put forth before a standing committee next month. We are hoping to complete the project within 18 months of commencement."
The pet project of Shiv Sena chief Uddhav Thackeray was planned nine years ago. Four years after the Central Zoo Authority approved a revised master plan, the project met with a roadblock in May, when several contractors were disqualified on grounds of incomplete documents provided to BMC. A civic official said, "While construction work on the enclosures is on, we are working on procuring the animals."
Catch up on all the latest Mumbai news, current affairs from Mumbai, local news, crime news and breaking headlines here
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Download the new mid-day Android and iOS apps to get updates on all the latest and trending stories on the go
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text:
Datele acestea se pot schimba in ORICE moment, politica Apple le permite developerilor sa schimbe situatia acestor aplicatii gratuite sau la pret redus oricand doresc asa ca verificati in App Store daca datele de aici corespund cu cele de acolo. Modificarile acestea sunt in general valabile pentru scurt timp asa ca fiti vigilenti.
Project Life
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You are Agent RX. One of the best agent from ISEN. Unfortunately ISENs secret military base,a floating fortress called ARIES has been compromised by unknown assailants. Only with stealth infiltration can recover ARIES. Are you up for it
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Chameleon Color
Descriere: Hello,
You have found Chameleon Color, the photo color changing application for iPads, iPhones and iPod Touch devices with a camera. Chameleon Color allows you to change base colors (White, Gray, Black, Red, Green, Blue, Yellow, Magenta, Cyan) into any o…
Men's Room Mayhem
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Take toilet gaming to a whole new level with this frantic line drawing game! Warning: contains punch in the face gameplay and some serious swiping action!
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A Little Solitaire
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Descriere: *****
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7 Planets
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Impossible Paths: A Puzzle Game
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Color Spatioplotter
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Special demand of our customers is high quality cleaning of houses, carried out by our company after redevelopment and repair of premises. The company offers services for general cleaning of houses after the construction work. Having made a choice in favor of specialists who know a lot about professional cleaning of houses, our clients do not spend their time and efforts on a complicated undertaking of general cleaning of a house after repairs or construction. Moreover, without special equipment, using only household appliances, it is simply impossible to clean the houses with high quality.
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Duration: 1.5 - 2 hours
Duration: 2 - 2.5 hours
Duration: 2.5 - 3 hours
For Custom Jobs, Large Apartments/Homes, and Small Offices
Who do I contact if I have any issues or questions?
You can contact the Customer Happiness Team at our phone or email us our email. Someone will respond to you immediately.
When are you open?
We are open every day 8am – 10pm.
What if I'm not there to let the cleaning person in?
That's okay! Just leave us detailed entry instructions when you schedule your appointment online so we know how to gain access to your home. Your home will be locked when the cleaner leaves.
Do I have to be home while you clean?
You do not have to be home as long as your cleaner has proper directions for entering and exiting your home. Please input these instructions when booking your appointment.
Will the same cleaner or maid show up for all my appointments?
If you're happy with your cleaner you had, we're happy to send them to all of your appointments. You just have to contact us to let us know and we'll make it happen!
Can I book a cleaning over the phone?
Yes, absolutely! Give us a call at our phone and we will set you up with a great home cleaning immediately.
How do I schedule a cleaning?
Simply click on the Book Now on the top of this website and complete the form. It shouldn't take more than 60 seconds and we'll contact you to confirm your appointment that same day!
Where do you serve?
We serve all boroughs of NYC
How do I log in?
Book, Re-Schedule, and cancel online here
Trust & Safety
Are you insured and bonded?
Yes, Maid Service is insured and bonded. We understand that it is a privilege to be in your home, and we are always careful. In the unlikely event that an object is damaged, please notify us within 24 hours.
Are you a pet friendly maid service?
Yes! At Maid Service we LOVE pets. All of our maids are trained to correctly deal with your furry family member.
Can I trust Maid Service cleaners?
Absolutely. All of Maid Sailors Cleaning Professionals are highly trained, background and reference checked, as well as insured and bonded.
How much does it cost to clean my home?
Maid Sailors pricing is based on the size of your home and the desired level of service. We operate on a flat rate basis given the number of bedrooms, and we also offer hourly services. Please see our price rates on our Pricing page.
What if I want a cleaner by the hour?
Our minimum appointment is a two (2) hour clean. If you would like to forego our standard pricing and hire an HOURLY cleaner, we can provide this at a cost of $60/hour per cleaner.
What does a Deep Clean include?
The Deep Clean service is a comprehensive top-to-bottom cleaning. We recommend a deep cleaning if you have not had your apartment professionally cleaned within the past 3 months.
It does not include cleaning baseboards, closets, interior windows, interior walls, inside the oven, inside the cabinets or inside the refrigerator, all of which are available at a reasonably priced additional cost.
What is a Move In/Move Out cleaning?
We all know moving is stressful. Combine that with all the boxes that need to be packed, furniture moved, and a long list of other preparations can be extremely time consuming. Our move in/move out cleanings are designed to prepare a home for a new tenant.
Please note that the move in/move out cleaning includes cleaning inside of the oven, insides of the cabinets, and inside of the refrigerator.
It does not include cleaning baseboards, closets, interior windows and interior walls, all of which are available at a reasonably priced additional cost.
Cleaning Supplies
Do Maid Sailors cleaners bring all necessary cleaning supplies to get the job done?
We bring all required products to give your home a great clean, aside from a vacuum (unless requested; see below), mop, bucket or step stool. If you'd like us to use a specific product, please let us know and leave it out for the cleaner to use.
I don't have a vacuum. Should I still use your service?
If you do not have a vacuum, simply request for the cleaner to bring a vacuum in the special instructions area. Please note, our cleaners do not carry large capacity vacuums. Our cleaners carry mobile vacuums as they have to travel throughout the day for jobs.
What if I don't have a mop?
Our cleaners bring a travel wet/dry mop (Swiffer) that can be used on non-carpeted floors.
Do you bring green cleaning supplies?
We have teams that do 100% green cleaning. Simply request it and we'll assign a green-cleaning team at no additional charge. (Please note this requires time flexibility)
Recurring Service
Do I get a discount if I'm a frequent customer?
Yes, customers who sign up for recurring service will receive discounts. For weekly service, you will receive a 15% discount. For service every 2 weeks, we have a 10% discount. If you book us every 3 weeks, you will receive a 7% discount. For service every month, you will get a 5% discount. PLEASE NOTE: The discount is not applicable until the 2nd cleaning.
How often should Maid Sailors clean my home or business?
Most of our customers differ in their individual needs, so it is difficult to provide specific guidance. Typically, our customers schedule an initial detailed cleaning of their home followed by a recurring cleaning appointment. By following this model, you can rest assured that your home is always clean and in top shape.
How much does it cost to clean my home?
Maid Sailors pricing is based on the size of your home and the desired level of service. We operate on a flat rate basis given the number of bedrooms, and we also offer hourly services. Please see our price rates on our Pricing page.
What if I want a cleaner by the hour?
If you would like to forgo our standard pricing and hire an HOURLY cleaner, we can provide this at a cost of $60/hour. Our minimum appointment is two (2) hours.
Is tip included?
Tipping is not mandatory or required in any way, but you have the option of doing so if you feel that you've received exceptional service. Maid Sailors personnel are not permitted to solicit tips under any circumstances.
What method of payment do you accept?
We accept all major credit cards. We no longer take cash or personal checks. Our online payments are processed by Stripe and though a fully secure 256 bit SSL protocol. In addition, we have full extended validation SSL security as well. Booking through Maid Sailors is safe and secure; we guarantee this.
Why is there a pending charge on my card before the cleaning service date?
A hold will be placed on your account (for authorization) in the amount of your total balance the evening BEFORE your scheduled cleaning date. If your service is cancelled prior to 5 PM the day before your service date, the hold will drop off in 3-5 business days. THE HOLD IS NOT A CHARGE. We only charge you after the cleaning has been rendered and will receive an email invoice shortly thereafter.
How do I change my billing information?
To switch your billing information, simply log into our online portal using your username and password and edit your billing information. The online portal login is at the bottom of your initial booking confirmation email.
What is your cancellation/rescheduling policy?
You can cancel or reschedule your service without a penalty 24 HOURS before your scheduled cleaning. There will be a $90 CANCELLATION FEE if you cancel or reschedule your appointment less than 24 hours of your scheduled appointment.
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Our Locations
Deep Clean Service
132 Crosby St, New York, NY 10012
New York
United States
Phone: +1 (929) 207-26-15
Email: [email protected]
Monday 08:00 – 22:00
Tuesday 08:00 – 22:00
Wednesday 08:00 – 22:00
Thursday 08:00 – 22:00
Friday 08:00 – 22:00
Saturday 08:00 – 22:00
Sunday 08:00 – 22:00
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Test Use Google's core infrastructure, information analytics and machine learning. EPIC submitted feedback to the FTC prior to the company's second privacy roundtable EPIC warned of the ongoing privateness dangers related to cloud computing and social networking privacy, highlighting the Google cloud computing complaint and Fb privateness criticism filed by EPIC in 2009.
A covered entity (or enterprise affiliate) that engages a CSP ought to understand the cloud computing atmosphere or answer supplied by a selected CSP so that the coated entity (or business affiliate) can appropriately conduct its own threat analysis and set up danger administration insurance policies, in addition to enter into applicable BAAs.
Cloud computing has a lot going for it – a world that has just been in recession and understands the perils of excessive investments, an IT idea that works on optimization of costs by means of shared services and elevated utilization and therefore highly appreciated.
Safety as a service (SECaaS) is a business mannequin during which a big service supplier integrates their safety providers into a company infrastructure on a subscription foundation more affordably than most individuals or companies can present on their very own, when complete value of possession is considered.
Host load in a real-world manufacturing knowledge heart at Google. I will step apart for a second right here although and have a look at how I can find out more about what SELinux is rejecting. When the Pulp service begins up it can try to connect with a MongoDB and to a QPID message dealer.
Examples of such information together with users e-mail, banking info, and full backups of people' exhausting drives. Offload the continuing operations and maintenance of your cloud infrastructure and functions with our subsequent-generation managed services options that make it easier to higher control your cloud prices, compliance and extra.


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|The Famdent Excellence in Dentistry Awards recognize the highest standards of excellence in the Dental profession, honoring individuals in respective fields for their outstanding achievement.
These Awards have been conceived and conceptualized by Anuj Arora, a Caltech alumni and Advisor to Famdent. Based out of London, his creative inputs and innovative mindset motivated him to initiate FAMDENT EXCELLENCE IN DENTISTRY AWARDS honouring stalwarts and enhancing the level of Dentistry in India. These awards are instrumental for motivating other Dentists to strive for greater heights and to contribute more actively towards promoting the Profession's intellectual, creative and ethical value systems.
This new endeavor was given a very warm welcome by the Dental Profession on its debut in 2013 - making it India's most coveted Dentistry Awards and hailing it as "the Indian Dental Oscars"!
The Awards give Dentists in India a great platform to benchmark their achievements against their peers; giving Award Winners/Nominees a professional boost to perform better, achieve higher, earn a long-lasting reputation and attract more patients. It is not easy to win the Famdent Excellence in Dentistry Award given the rigorous judging process; making the Winners true Stalwarts in their respective categories.
We go the Extra Mile to recognize our Winners!!
We make sure our Award Winners are given that extra special recognition beyond just receiving an Award.
Founded by Dr. Anil Arora & Dr. Jyotika Arora; Famdent is now one of the leading Dental Publications & Dental Event Organisers in India. Fast expanding into other avenues in Dentistry, Famdent constanty aims to achieve new heights in the field of progressive Dentistry in India. For more details about Famdent, visit www.famdent.com


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Long Hill, nature center eyed for community center locations
Those clamoring for direction from the town's Senior/Community Center Building Committee received just that last week when four architecture firms were chosen from a list of 12 to come up with proposals for a pair of potential site locations for the project.
The first location is the Long Hill Administration Building, located at 6254 Main Street, that currently houses dozens of Trumbull Public School system employees, including Superintendent Dr. Gary Cialfi.
"What's in there right now is not the optimum use for the building, and we think it could be renovated to meet the needs of the community better," said Town Council member Joe Pifko, who's been tasked with co-chairing the committee. "The big problem would be moving the educational services to another site, but right now, all we're trying to find out from the architects is what they think of it as a legitimate site for a community center and what they think they can do with it.
"There might be a third site in the future," he added. "Right now, these two are just samples of properties that we want them to see and consider — nothing is definite."
The second property that the four firms will investigate is the Nature and Arts Center, formerly the Wagner Tree Farm, located at 7115 Main Street, right off Route 25.
"We liked this one because it's on a main road, there's no intrusion to neighbors, it has a low impact on the surrounding community, and there's a traffic light that allows drivers to take a left-hand turn onto the property," Pifko told The Times Wednesday, May 25, the night after the committee's most recent meeting.
"The negative is that it's on the edge of town and we'd prefer a more central location, but the reality is we don't have that ideal flat, central location where we can put this thing," he added.
The four architecture firms will return in four weeks on Thursday, June 23, and will each give the committee a one-hour proposal of the two sites.
Pifko said the presenters — all from Connecticut companies — will make their pitch in a closed meeting, where they ask the same questions and they will be ranked by each member of the committee, similar to how they whittled the top four firms from the list of 12 last week.
"We're asking the firms about the sites — what they can do there, but more importantly, if they think the location is great or if they don't think it's great," he said.
"We will discuss all four presentations immediately after they're done," he added. "It will be an all-day meeting and we can't have news of one proposal leaking before another company gets to present — it wouldn't be fair."
Far from over
For those worried about the committee spending $175,000 on an architect without a site in mind — or worse, chosen — Pifko reassured that the committee was using a "slow, cautious process" that would unlikely yield a referendum anytime this year.
Specifically, he pointed out that the community was surveyed between Aug. 19, 2015, and Jan. 15, 2016, resulting in 1,100-plus responses, and four public hearings were held throughout the last 15 months to gauge residents' opinions on the project that ranged from an exercise room to a coffee area to a gym that houses basketball and volleyball courts.
The most important feature identified by residents in the survey was meeting and conference space with 79.38% of responders checking off that box.
"That was our initial step and we were presented with some original findings," Pifko said. "It doesn't mean that the time for public opinion is over; rather, when an architectural firm is chosen, they will be working with us and meeting with the public to design a facility that provides services to all members of the community.
"Nothing is going to be voted on or built without the public getting an opportunity to provide its input," he added. "It's far from over."
Listening to the public
Vicki Tesoro, who ran for first selectman in November, voiced her concerns with the committee's process in light of a petition written by fellow Democrat Eric Paulson that aims to halt any work until a community-wide survey is conducted and more public hearings are held.
"One of the flaws in this process can be seen in the confusion coming from the administration as to what is being built," Tesoro told the Times May 24. "The First Selectman announced early in this process that a state-of-the-art senior center will be built and that it is now a 'done deal.' "Reading and listening to comments made by some in the administration reveals that this center has not been completely thought out," she added. "Further, the residents clearly disagreed with Island Brook Park as a site. When residents attended a Town Council meeting to be heard, they were kept waiting for over an hour, only to find out from the Building Committee Chairman that it was never a suitable location."
For his part, Pifko said that that meeting could have been handled differently, but wanted to stress that the committee has been listening to public feedback.
One example he cited was a property off of Middlebrooks Avenue.
"We heard some real good criticism on a real good piece of property and we ended up removing it from the pile of possible locations because of how the public responded," the co-chairman said. "Plenty of change has happened already based on feedback — the public has had a significant impact on our decisions so far and they will have ample opportunity to comment in the future."
Site, plan, cost
Perhaps the most maligned group in town over the first half of this year, the Senior/Community Center Building Committee has three responsibilities — pick a site, come up with a plan for the building, and determine how much it will cost.
"The Town Council and the people of Trumbull will get to decide if they want this or not," Pifko said. "Nothing is being forced upon them that they don't want."
Nonetheless, criticism prevails.
"We are now spending hundreds of thousands of dollars on renderings for a center that is undefined in purpose, with no site selected and seemingly opposed by the community," Tesoro said. "It is time to take a breath, step back, and reset the entire process and to stop wasting taxpayers' money.
"Let's do this right the first time," she added. "The process should begin with a thorough survey of the community done by experts in the development and delivery of these kinds of surveys.
"Focus groups and public hearings should also be part of this process. That way we can determine what, if any, kind of center the community would like to see and what programs and type of facilities the community wants. Then we can move forward."
Time to stall
The Democratic leader said that a revamped survey process might show that the people do not want a new center at all, but would prefer to have an existing center or building be renovated — something that the chosen committee sites took into consideration last week.
"It may show that a standalone senior center is not what the seniors want or it may show that our residents are in favor of a Community Center," Tesoro said. "We may find that the people prefer not to spend the money and bond for a multi-million dollar building...
"If we are going to build something new or renovate an existing structure, let's build something the residents demand, not what the administration thinks they want," she added. "That is sound, simple practice that is fiscally responsible and transparent."
In response to Paulson's petition and Tesoro's stance, First Selectman Tim Herbst said that the Trumbull Democratic Town Committee needed to decide whether it was either going to support the project or be against it.
"They're not consistent, they're negative and they're destructive," he said, further emboldening his position against his opposing political party.
"When they see something they don't like, they use the same old tactic to reconcile it: stall, hinder and delay," he added. "It's all they know how to do and I'm not surprised they're playing this card again, but it's not going to work this time because there will be plenty of time for more feedback and suggestions. And, if residents don't want to wait for the next public hearing, they can call my office and tell me what they think should be done in the meantime."


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Last Updated on
Raw milk is not pasteurized or heated to a specific temperature to kill harmful germs that may be present in it. Pasteurization is the best way to ensure that milk is safe for babies to drink. You should avoid giving raw milk to babies as it could be harmful for your child.
What is Raw Milk?
Unpasteurized milk is raw milk, as the fluid that comes out of the body of an animal needs to be treated before giving it to babies. Though it is said that the process of sterilization destroys the key elements and robs the milk of its nutrients, it is safe to drink only pasteurized milk.
Nutritional Value of Raw Milk
The composition of milk varies based on the breed, the species, the stage of lactation, and the animal's food. Its nutritional value is very high, which can be seen in the table given below.
|61 g
|Omega 6
Source: https://www.healthline.com/nutrition/foods/milk#section1
What Are the Benefits of Raw Milk for Babies?
Raw milk is deemed to be helpful in many health conditions as it has a wealth of nutrients.
- Raw milk helps in maintaining skin health and removes allergies.
- It boosts immunity and helps in losing weight.
- It gives neurological support and aids digestive issues.
What Are the Risks Associated with Drinking Raw Milk for Babies?
As much as it has benefits, the risks of drinking raw milk outweigh its pros any day.
- Raw milk contains bacteria such as Listeria, Salmonella, and E.coli, which are potentially dangerous bacteria and can adversely affect young children with a weak immune system.
- Sometimes, outbreaks occur due to consumption of raw milk.
- It can lead to health risks by causing serious foodborne illness.
Can You Make Homemade Formula Using Raw milk?
Raw milk formula for infants is required when moms of newborn babies aren't able to produce enough breastmilk to satiate the baby's demands. A nutrient-dense formula can be made using unpasteurized milk and other ingredients such as lactose, homemade whey, healthy oils, and gelatin. If you want a variation, then goat milk is the next option. Is goat milk safe for babies? It is rich in fat but lacks folate, and is low in Vitamin B12, which are both essential for infants. But as much as it is possible to make formula, it is definitely not advisable as it could pose dangerous side-effects to the baby.
Feeding raw milk to babies is a major concern for parents. Pasteurized milk is safest to use for babies. Raw milk harbours bacteria which is harmful to infants. Ensure that the milk fed to your baby is procured from healthy cows and has been stored and handled carefully.
Also Read: Milk Allergy In Babies


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The Disastrous Effects of Donald Trump's Tariffs
When the United States rose to international prominence in the 20th century, its championing of global markets ushered in a new era of free trade. The countries who participated quickly realized unhindered trade is the key to economic betterment; that free trade agreements like NAFTA could mutually benefit all those who participate. Today, however, President Donald Trump paints a very different picture. From the first weeks of his presidential campaign, Trump has railed against free trade, decrying other world powers, notably China, as "ripping off" the United States while insisting that trade is a zero-sum game with strict winners and losers. This sentiment is a sharp diversion from the feel-good era of free trade under Bill Clinton and George Bush in the 1990s and early 2000s, in which the world's major nations flourished under a so-called goldilocks economy. Facilitated by international integration of capital markets, global exports relative to world GDP rose from 12.7 percent in 1990 to nearly 19 percent in 2000. Relatedly, China began to claim a significant share of total world manufacturing, largely due to a booming American economy in which GDP grew at an unprecedented rate of around 4 percent, allowing for a global economic upswing that lasted until 2008.
The recent effort by Donald Trump to channel rhetoric into action and cut perceived American losses in global trade culminated in the June 1st implementation of 25 percent steel and 10 percent aluminum tariffs on the EU, Canada, and Mexico, countries that were largely exempt from tariffs under the previously noted American policies of free trade. Under an obscure section of the 1962 Trade Expansion Act, President Trump is allowed to act unilaterally and bypass Congress, which he invoked to claim that foreign steel and aluminum constitute a threat to national security . The real threat to the United States, however, is not the current trade imbalance, which carries along with it a variety of macroeconomic factors which dismantle Trump's simplistic populist rhetoric, but rather the impending retaliation from the host of countries Trump has targeted. From a global standpoint, as Trump begins to confront the world's supposedly rigged trade policies by initiating an abundance of tariffs on everything from Chinese production materials to planned duties on European automobiles, he threatens not only America's longstanding credibility as a reliable trading country, but also risks sending the country into a battle on trade, if not trade war, of ballooning proportions. Domestically, the fallout is equally destructive as the tariffs will ultimately harm American manufacturing and likely have the potential to spell political disaster for the Trump wing of the Republican party.
In no place has the international outrage at Trump's tariff plan been more coldly expressed than at the recent G7 summit in Charlevoix, Quebec. French finance minister Bruno Le Maire, who spoke in a representative fashion for the G7 members, stated that "we cannot understand the American decisions on steel and aluminum" as Trump railed on twitter after the summit, at one point saying "Fair Trade is now to be called Fool Trade if it is not Reciprocal. According to a Canada release, they make almost 100 Billion Dollars in Trade with U.S. (guess they were bragging and got caught!)." Despite the fiery rhetoric after the G7, the World Trade Organization's metrics the president's claims to be unfounded. While the US weighted tariff on imported goods is 2.4 percent, lower than the EU at 3.0 percent and Canada at 3.1 percent, it is still higher than many other countries that Trump has set out to 'correct'. Coinciding with the data, international patience seems to have waned to a point where a trade war seems all the more likely. Emmanuel Macron has called the deal "illegal" and a "mistake" while Justin Trudeau slammed the tariffs as "insulting" and insisted that Canada "would not be pushed around". Aside from giving political soundbites, citizens of allied countries, like Canada, have taken it upon themselves to boycott American products and companies, refusing to buy staple products such as coffee and beers. But the real threat to Trump risks absorbing is the impending retaliatory response by countries who Trump has so recklessly attempted to take advantage of.
Rather than conceding to Trump's demands, retaliating countries have announced plans to or have already levied additional tariffs on a plethora of other US goods or increase the rates of existing tariffs, which will in effect continue the cycle of Trump's primary steel and aluminum tariffs. While the goods targeted have been primarily chosen to inflict economic damage in a variety of US economic sectors, an important political component of the tariffs should not go unscrutinized. It is certainly no coincidence that EU duties levied on Kentucky bourbon and Harley Davidson motorcycles from Wisconsin coincide with the Republican majority leader Mitch McConnell and Speaker of the House Paul Ryan, respectively. By pressuring the local economies of these areas, European leaders hope to ultimately exert political pressure on these leaders in an effort to force a change of hand in their support of the president's policies. In fact, Harley Davidson, among other U.S. based companies, have already announced a shift of some production overseas, where production costs will be cheaper, perhaps representative of the real economic impact of the imposed tariffs.
Trump's tariffs aren't problematic solely from an intergovernmental perspective. By dramatically increasing the prices of steel and aluminum, the tariffs will have a secondary effect on US manufacturing, and eventually consumers. Perhaps the most potent example at this current time is that of the US auto industry. In 2017, the auto sector accounted for 26 percent of US demand for steel. While some steel is manufactured in the United States, the vast majority is imported from elsewhere, namely Canada, Brazil, South Korea, and China. A 25 percent levy on the cost of importing that steel, would mean that auto prices would soar, especially if manufacturers decide to pass the full cost of the tariff onto the consumer. This idea can be extended to other commodities as well, meaning everything from home appliances to aluminum cans would be subject to a price shock. If Trump decides to levy tariffs on components essential for production, manufacturers can expect to see their costs rise as can consumers.
Additionally, Trump has threatened a 25 percent tariff on actual auto imports, not just the material needed to build them. At first glance, one might consider this a protectionary measure that would bolster the American-made car market. But that's not the case. Nearly 3 million GMs, Fords, and Fiat-Chryslers are imported every year meaning that in addition to the already increased price of imported metal, US carmakers would be hit twice by these protectionist policies. To solidify this claim, LCM Automotive, a leading researcher in the auto industry, has US car manufacturers projected to lose 1 million auto sales a year. While American commodity manufacturers such as U.S. Steel and Century Aluminum will obviously benefit from Trump's tariffs, they account for a negligible value compared to the rest of the US market that relies on foreign imports to produce and sell goods. Further, consumers will inevitably end up on the losing side, meaning that the political ramifications could be significant for Republicans, especially those who ideologically connect with Trump. Since the tariffs will substantially hurt manufacturers and consequentially many of the blue collar working class Americans who comprise the president's base, Trump will have a tough time selling his image as a populist champion of the American people.
As President Trump's protectionist trade policies begin to impact markets, one has to wonder whether or not these tariffs will remain in place. On one hand, Trump is helping a small segment of his domestic manufacturing base remain afloat in a sea of competitive global prices. On the other, Trump has angered some of the most important allies and powerful people in the free world to a point where retaliation is inevitable and a full-fledged trade war seems more than likely. The scale, it seems, weighs heavily in only one of the above directions. As is, it's time for Donald Trump to consider alternative actions that will minimize the economic disparities he is trying to correct. Instead of attacking a global trade system in which the US, as the most formidable member, has the upper hand, Trump should focus on the current fiscal deficit. He must urge Congress to reconsider the latest tax overhaul that will in time transfer billions of dollars to billionaires. He must promote education and job placement programs to correct for the country's once formidable manufacturing base. This means reversing his disastrous tariffs that have already begun to hurt American manufacturers and the working people that depend on the jobs they provide. But given the extent of the president's powers and his relentless insistence that the American economy will benefit from these policies, it is obvious that these ideas will never be implemented. Therefore, the only option left for America is to flip the table over, first in this year's midterms and then in 2020.
Edited by John Weston


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Panel Processing lays up panel with the beautiful look of real leather. It uses a recycled leather veneer made from pulverized leather fibers extracted from old car seats and leather tanneries from EcoDomo.
This recycled leather is not only beautiful but it is a green product that is available in multiple colors and textures. This has an exceptional combination of elegance, sustainability, and durability for wall, ceiling, and furniture applications.
We utilize the recycled leather veneer (RLV) in 0.8 mm or 1/32", in the color and texture that is specified. We will lay up the veneer on multiple thicknesses of MDF and machine your panel to shape and size, and provide edge finishing options as needed. View the EcoDomo site for options on the recycled leather veneers that we are able to provide and fabricate for your completed project.
Panels can be machined to your specifications. Panels can be laminated double sided. Standard sheet sizes are 49" X 97" with 0.8mm veneer. it can be applied to MDF and HDF.
Multiple custom options available for texture thickness and finishes. Leather veneer supplier, EcoDomo, can match leather swatches that are provided
Have something to say? Share your thoughts with us in the comments below.


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As older blockbuster drugs lose patent protection and generic competition increases, many pharmaceutical companies are focusing discovery efforts on therapies with the potential to treat multiple niche populations. Increasingly, innovative small and emerging pharma firms are developing new drug candidates with orphan or breakthrough therapy status that are ultimately licensed or sold to large brand manufacturers.
These companies rely heavily on contract manufacturing and development organizations (CDMOs) that can provide in-depth scientific expertise and achieve under rapidly accelerated timelines the development of cost-effective, robust, reliable processes that consistently yield high-quality products.
Until recently, most pharmaceutical firms were not interested in the development of small-volume drugs due to fears of limited returns. With the age of the blockbuster drug now history, many drug companies are finding that niche therapies, particularly those that may treat numerous indications, not only provide patients with life-saving medications, but also realize attractive financials if developed in a streamlined and cost-efficient manner. There are over 7,000 different types of rare diseases and disorders, yet only a couple of hundred approved therapies designated as orphan drugs. According to EvaluatePharma, although the average Phase III development time for orphan drugs is not shorter than that for non-orphan drugs, the Phase III drug development costs for the former are half those of the latter, and the anticipated return on investment for a Phase III/filed orphan drug is nearly twice that for a non-orphan drug.
As a result, EvaluatePharma estimates that the orphan drug market is growing at an annual rate of 11%, more than double that of the overall prescription drug market (5%), and by 2020 will reach $176 billion in annual sales and account for 19% of the total non-generic prescription market. In 2013 alone, 260 orphan drug designations were granted. In 2014, the FDA approved 15 NDAs and seven BLAs with the orphan drug designation, along with 24 supplemental approvals.
In 2014, FDA approved 15 NDAs and seven BLAs with the orphan drug designation, along with 24 supplemental approvals.
Many companies are also pursuing the new breakthrough designation established in 2012 by FDASIA, the Food and Drug Administration Safety and Innovation Act. A candidate qualifies for breakthrough therapy designation if preliminary clinical evidence suggests that the drug may have substantial improvement over available therapies on at least one clinically significant endpoint. The development and approval times for breakthrough therapies are typically half that of the seven years for conventional drugs, and both the sponsor and CDMO benefit from greater FDA guidance and communication with the agency. FDA's CDER approved 14 breakthrough therapies in 2014 and nine in 2015 as of August 21.
Of the firms pursuing the development of orphan drugs and breakthrough therapies, many are small or emerging pharmaceutical or biopharmaceutical companies focused on niche, small molecule therapies. These companies often have limited resources in terms of laboratory, analytical, and manufacturing equipment (indeed, some are virtual companies in that respect) and depend heavily on service providers to perform crucial process and formulation development, validation, regulatory compliance, and manufacturing activities. The choice of CDMO can therefore have a direct impact on the success or failure of the new drug.
Deeper Science
Whilst technical capabilities and synthetic expertise in a wide range of chemistries is necessary for any CDMO, the ability to accomplish practically any chemical transformation is no longer sufficient when supporting small and emerging pharma companies that are focused on the development of small-volume, niche drugs for targeted patient populations. Clearly, an awareness and understanding of their needs related to the development of orphan and fast track drugs and breakthrough therapies is a must.
Innovative smaller pharmaceutical organizations, particularly those in North America, also expect to have deeper discussions about technology and science. They no longer see CMOs/CDMOs as simple suppliers of manufacturing services; they select providers that can offer a unique depth of expertise, knowledge, and know-how that can help them address the challenges they face throughout the development and commercialization process, and increasingly at earlier stages. The same trend is also occurring with larger pharmaceutical companies that outsource discovery and early phase development.
All of these firms rely very heavily on CDMOs that have a deep understanding of both the processes and molecules they are trying to develop. Service providers with the right combination of technical capabilities and experience can help sponsor firms to reduce development times and costs, and provide assurance to regulators that the ultimately chosen cost-effective process will be robust and reproducible, and provide product with consistent quality, regardless of any need for technology transfer or scale-up.
It should also be noted that the rapid pace of advancement in chemical and biological technologies ensures that no one company can have expertise in all of the latest techniques and methodologies. Therefore, in addition to having specialized expertise in several scientific areas with applicability to pharmaceutical development, such as particle engineering and chromatographic purification on the lab to commercial scale, CDMOs viewed as preferred partners also have capabilities designed to aid in process understanding, and belong to a network of providers with other specialized expertise that they can tap if needed.
One technical area of particular importance is particle engineering. Because 40-60% of all NCEs are poorly soluble, CDMOs with the ability to identify solutions to solubility challenges have a real competitive advantage. Experience in particle engineering and the ability to create a wide range of physical forms with enhanced solubility is becoming a necessity today. State-of-the-art technologies such as spray drying and hot melt extrusion, combined with advanced modeling tools, enable significant reductions in development times and costs while providing high quality APIs with desirable pharmacokinetic properties.
Relationships Matter
Indeed, relationships also play a crucial role in the success of accelerated drug development projects. According to a recent report by the Tufts Center for the Study of Drug Development (CSDD), to better serve public and patient communities by reducing rising development costs, shortening cycle times, and delivering better innovations, many pharmaceutical firms are also implementing highly collaborative approaches to validating drug targets; integrating real world data into the R&D process; employing flexible and adaptive clinical trials; and using green manufacturing techniques that include the sharing of pre-competitive information among government agencies, academia, patient groups, payers, and providers.
Because there is much less time to develop and validate the manufacturing process and analytical methods and generate safety and efficacy data, it is important that the CDMO and sponsor company have established a more strategic relationship, with the CDMO acting as an extension of its customer rather than only as a vendor. Strong sponsor-CDMO communication is particularly vital, so that potential problems can be caught and addressed before they become major setbacks.
Good relationships with FDA representatives are equally important. Orphan drug, breakthrough therapy, and fast track designations require increased interactions with the agency to ensure that the shorter development times can be met. CDMOs that have experience working with the agency and recognize the value of additional meetings and guidance from the FDA will be able to not only provide enhanced service and support to their small and large pharma customers, but also help reduce risk and facilitate earlier approvals.
To address the development challenges presented by the increasingly complex drug candidates of today, pharmaceutical companies are also seeking CDMOs that emphasize collaboration within their own firms. For accelerated development projects in particular, effective cross-functional teams are needed to ensure that CMC data development and stability studies are completed in a timely fashion, a suitable plan for scale-up and production is in place, the needs of other international authorities are considered for global products, and lifecycle management issues have been addressed. In fact, CDMOs with integrated capabilities across all stages of development and commercial manufacturing are increasingly preferred over traditional CMOs.
Development by Design
There is very fundamental science behind all of the phenomena that occur during chemical/biochemical processes. The use of modeling technologies based on first principles provides the ability to design robust processes that behave the same regardless of scale. The application of quality-by-design (QbD) and process analytical technology (PAT) methodologies during both the development and commercialization stages, combined with the use of advanced modeling, allows simulation of the full design space well beyond what is possible using a design-of-experiment approach alone. At Hovione, this approach is a very powerful one that leads to the development of highly robust and reproducible processes, and in turn ensures smooth and rapid technology transfer and scale-up of the same high quality products regardless of volume or location. The enhanced process understanding and reproducibility obtained are also well-regarded as strengths by the FDA and other authorities. This approach ensures that only value-adding activities are performed, and are performed at the right time and in the most efficient manner.
In Conclusion
Despite the turbulent times currently facing the pharmaceutical industry, there are many opportunities for both smaller emerging and larger established pharmaceutical and biopharmaceutical companies to develop novel medical treatments that will improve the lives of patients suffering from a myriad of as-yet-untreated diseases. CDMOs with a deep understanding of the process development and commercialization needs of both small and large sponsor firms faced with accelerated timelines can help speed new safe and efficacious drugs to market while ensuring that they are produced using cost-effective, robust processes.
Hovione, with years of experience developing and producing small-volume APIs at its US site, is ideally positioned to support accelerated orphan drug and breakthrough therapy projects. This is of particular benefit to emerging pharma clients, which enables the transition to commercial production regardless of the ultimate owner of the IP. We recognize that each customer has unique needs, and are therefore focused on meeting those needs through the tailoring of our comprehensive set of chemistry, particle engineering, process and formulation development, manufacturing, analytical, and regulatory capabilities.


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OMG how many times a day do I say this? I'll work out, but first… I have to do the dishes, clean the kitchen, put clothes away. I will go for a walk when the hubs gets home, but first …. I have to make sure the kids have dinner, change diapers, put away more clothes.
Let them get the best of you, don't let them get the rest of you
My yoga instructor said this during a holiday class at corepower yoga. It stopped me mid practice and I repeated it to myself until I was sure it was memorized. God, how many times a day do I put EVERYTHING and EVERYONE else before me? Constantly I put myself and what I need on the back burner. Sure as a mom and wife it's so natural for us to make sure our home and family are cared for, I am not saying to stop the wonderful things we do daily that keep our lives running, I am saying if we don't put ourselves first, if we don't tend to our needs or growth as an individual we will have nothing but the dregs of our existence to offer to those we love.
Let them get the best of you
I am my best self when I am rested, when I get to be active or work out and when I get a small amount of alone time-preferably to meditate or read. Let the dishes rot in the sink, let the clothes sit in a crumpled pile on the counter and for fucks sake dinner can wait 20 more minutes. Almost everything we prioritize over ourselves can wait 20-60 minutes while you get a dose of what rejuvenates you and if it can't ASK FOR HELP!
Don't let them get the rest of you
The tired, worn down, bitter mom, the one that wants to throat punch her husband when he says he has to travel one more day to an awesome city for work, the mom that wants to scream when one more hand pulls on her pant leg is the mom that needs to reevaluate her self care standards. Feeling crowded, overwhelmed and annoyed is a sign that you need space and yes- you have to create it for yourself. No one, not even that amazing husband of yours, is going to protect you or your sanity, nor is it his job, it's yours!
Take pride in the fact that you are an amazing person with desires, hobbies and interests that extend beyond your husband and children. Find the thing that energizes you and DO IT! Fill your cup so you can share yourself with others, take that time for yourself so you can multitask the day away like the bad ass parent you are.
Stay Zen Bitches,


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Kimi Raikkonen's motivation for quitting Ferrari for Sauber is unclear when retirement might have been a better option
The two-time World Champion will be 41 when his two-year deal with Sauber expires
KIMI RAIKKONEN's decision to re-join Sauber is a great story -- but would it not have been a better idea for him to retire?
Sure, the two-time world champion still has the speed, we saw that at the Italian Grand Prix where he set the quickest ever lap time in Formula One to take pole position.
Yet he was unable to convert that front spot into a win at Monza and as a result he is still waiting for his first victory since the Australian GP in 2013.
Raikkonen has signed a two-year deal with Sauber, a contract which will take him up to 41-years-old when it expires.
The Finn of course made his breakthrough with the Swiss team in 2001 before moving to McLaren a year later.
After all, Sauber are unlikely to be able to promise podiums and he is likely to be spending his Sundays trundling around near the back.
A final pay day is one reason he's signed on, however, Sauber's modest reserves means he will not be paid anywhere near his estimated £10million a year salary he currently gets at Ferrari.
Maybe he wants his final few years in F1 to be enjoyable?
Is it simply a case of convenience? I remember Raikkonen having a conversation with former Sauber team boss Monisha Kaltenborn where he told her his best times in F1 were with Sauber.
He also added that he liked the team because their factory in Hinwil was close to his home and it was easy for him to get too.
However, Raikkonen's decision is strange in that he will commit another two years of his life to F1 - taking time away from his young family.
Raikkonen's switch to Sauber, also has the knock-on effect of taking up another seat on the grid.
While of course this is no concern for Raikkonen, who clearly feels he has the desire to compete at the top level, albeit in an uncompetitive car, him staying will remove the potential for a younger driver from making the switch to F1, namely Antonio Giovinazzi, Sauber's current reserve driver.
Whatever the reason for Raikkonen staying in F1, it is an interesting one.