text:
More than 90% of of cancer related mortality is caused by metastasis. To
develop new therapeutic strategies it is vital to understand the initiation and
progression of metastasis. To identify and isolate metastasis initiating
tumour-cells scientists developed a fluorescence-activated cell sorting
(FACS)-based array. There are two types of metastasis-cells: metastasis-cells
from low-burden cells and metastasis-cells from high-burden cells. After being
transplanted, low-burden metastasis-cells showed that they have a considerable
amount of tumour initiating ability and could differentiate to produce
luminal-like cancer cells. When low-burden metastatic cells progress to
high-burden metastasis cells they get an increased proliferation and MYC
expression. This can be weakened with the use of inhibitors. This all supports
a hierarchical model in which metastasis is initiated by stem-like cells, and
can progress from low-burden to high-burden metastasis cells.
The human breast contains two kinds of epithelial lineages: the
basal/myoepithelial which contains stem-cells, and the luminal lineage which
contains progenitor cells and mature cells. The scientists used breast tissue
from the mammoplasty of three individuals. With the use of numerous statistical
analysis they concluded that basal/myoepithelial and luminal lineage is
different for everyone.They focused in this experiment on a particular subtype,
because this subtype is the most aggressive and there is no suitable treatment
for it. The patient-derived xenograft maintained the same properties in the
mice as in the patients and because of this it was suitable for the studies of
human metastasis.
To isolate the metastasis cells from the patient derived xenograft mice
they developed a new FACS based array. With this they were able to detect
metastatic cells in 70% of the patient-derived xenograft peripheral tissue from
the mice. The mice were analyzed when their tumours reached 20-25 mm in
diameter. The growth kinetics was consistent within each model.
Although the tumour of every animal had about the same diameter they all
had great variation in metastatic burden. The scientists also found out that
PCA plots for mice with low burden metastasis cells were further away from the
tumour they derived from than high burden metastasis cells. Other experiments
also showed that low burden metastasis cells liked to form clusters with each
other while high-burden metastasis cells liked to form clusters with primary
tumour cells. The scientists found out that low burden metastasis conserved
their basal/myoepithelial signatures. They had expressed higher levels of 22
basal/myoepithelial genes and expressed lower levels of 7 luminal genes.
By focusing on clustering only the metastasis cells the scientists
discovered incredible heterogeneity in differentiation, which correlated with
metastatic burden. Akin to the mammary gland metastatic cells organized into
two different clusters, where the low-burden cells were the most
basal/stem-like and the high-burden cells were the most luminal-like. The scientists
concluded the same conclusion with lung metastatic cells. Which means that it
is a conserved phenomenon in each model. There were some differences between
gene expression of lung metastatic cells of different models, but they were not
enough to cluster metastatic cells separately by patient derived xenograft
In order to investigate heterogeneity at protein level scientists performed
immunostaining for a basal and luminal gene. Tumour cells found in
micrometastatic from low-burden tissues had a high percentage for the basal
gene and luminal gene and tissues from high-burden tissues had a high
percentage for the luminal gene and were heterogeneous for the basal gene. This
suggest that differentiation status correlates with metastatic burden in
By means of single cell analyses scientists discovered that in the
low-burden metastatic cells had high levels of pluripotency genes. These genes
suggest that they are exploited embryonic programs for self-renewal and
maintenance. Low-burden metastatic cells also expressed higher levels of
typical EMT-markers, except for an EMT-marker which was typically found in
normal basal/stem cells. All these findings are consistent with previous
reports which show that EMT promotes stemness in mammary gland, and suggest
that low-burden metastatic cells utilize an EMT-program to make dissemination
easier. Further studies also revealed that genes involved in the DNA damage
response, chromatin modification, differentiation, apoptosis and the cell cycle
were differentially expressed in low-burden metastatic cells.
Because of the heterogeneity in metastatic cells scientist wondered if
stem-like cells directly give rise to luminal-like cells, or if the luminal
cells are originated from founder-cells. After an experiment the scientist
concluded that luminal-like cells can derive from cells that disseminate at the
early stages of primary tumour growth.
To test the growth and differentiation capacity of stem like metastatic
cells, scientists transplanted low-burden metastatic cells into mammary glands.
Interestingly 2 of 4 transplanted cells produced large tumour, while primary
tumour cells never produced tumours, even at 100 fold high numbers. This is
consistent with the previous reports which showed that PDX tumours are more
efficiently increased as fragments than dissociated cells. After single cell
analyses scientists concluded that low burden-metastatic cells have high tumour
initiating capabilities, and that they can give rise to luminal-like tumour
cells. This supports the hypothesis that stem-like metastatic cells give rise
to luminal metastatic cells.
Another interesting question the scientists had was is stem-like cells were
present in tumour cells, or if they evolve after interaction with their
microenvironment. After a test the scientists concluded that primary tumours
contain a rare subpopulation of stem-like cells, and that the percentage
correlates with metastatic potential. Afterwards scientists wanted to know if
enrichment of this stem-like signature in primary tumours may be predictive of
distant metastasis in human patient data sets. After an analyses the scientists
found that 16 of 55 genes associated with stem-like metastatic cells were
significantly prognostic.
Previous work has shown that metastatic cells in different organs display
distinct gene expression signatures. Supervised clustering by target organ has
shown that metastatic cells in brain, bone marrow and peripheral blood had
differences in gene expression patterns. Brain metastatic cells were the most
CTC's are very important for use as a 'liquid biopsy' for diagnosis and
prognosis. Most CTCs and bone marrow DTCs clustered with 'intermediate'
metastatic cells, which may be because the cells were harvested from animals
with intermediate burden. However, 16.7% and 10.7%, showed a more
basal/stem-like signature, suggesting that these stem-like cells may represent
the true metastatic seeder cells.
We also observed a shift towards a more proliferative signature associated
with increased metastatic burden. Low-burden metastatic cells expressed higher
levels of rest and dormancy-associated genes. Higher-burden metastatic cells
appeared to enter the cell cycle, expressing lower levels of quiescence and dormancy-associated
genes and higher levels of cell-cycle-promoting genes.We also detected primary
tumour cells (22.2%) with this less-proliferative signature.
These findings prompted us to test whether blocking this switch from
dormancy into the cell cycle could inhibit metastatic progression. Since we
observed high levels of both MYC and CDK2 in more advanced stage metastatic
cells , we chose to test a CDK inhibitor that has been shown to induce
apoptosis in high MYC-expressing cancer cells via synthetic lethality. We
hypothesized that apoptosis would be induced in metastatic cells transitioning
into proliferation, since they appear to upregulate MYC. After testing this on
mice we found that by looking in high resolution at gene expression in single
metastatic cells, we have uncovered previously unrealized diversity in
differentiation and gene expression relating to the metastatic stage ,and
demonstrate that this approach can facilitate the identification of new
potential drug targets with efficacy against metastatic disease.
To begin with the analysis the researchers first gathered the cell lines
and the xenografts of the tumour tissues, which were grown and acquired
according to standard and ethical protocols. The xenografts were divided into
tumour fragments and propagated into the breasts of the mice. When the tumours
became palpable, that's when the tumours were measured weekly to oversee their
growth rate. The tumour fragments were stored by freezing them in liquid
nitrogen. All animals from which xenografts were derived were euthanized at the
end, when the tumours had grown to about 20 to 25 mm in size. During the
resection experiment, tumours were usually removed when they reached the size
of about 10 to 12 mm. The animals on which resection was performed were brought
back to their colony and were warranted to grow metastases for 8 weeks, during
which lung tissue was gathered and analysed by fluorescence-activated cell
sorting (FACS) for human cells.
In order to measure the functional activity of metastatic cells, orthotopic
transplant experiments were performed on the animals. Particular metastatic
cells in the lymph nodes, as well as particular tumour cells from matched
animals, were segregated by FACS and combined from various animals. The sorted
cells were formed into pellets and inserted into a media. Diluted versions of
these were inserted into the breasts of 3.5-week-old mice and grafts were taken
after 4.5 months when the primary tumours became 20 mm in size.
After this began the dinaciclib treatment experiments, which were
administered when the tumours became palpable. The dinaciclib was primed and
acquired according to protocol. The mice were randomly appointed to treatments
when the tumour cells were transplanted and analysed with the help of the
single-blind design. In total, 49 animals were injected with the treatment
three times a week. Animals were measured twice a week to report primary tumour
growth. The mice were euthanized at the end of the treatment or earlier if the
tumour reached 20 mm in diameter. Animals which developed unfavourable effects
were ruled out of the study.
The microarray gene expression values were calculated using some form of
statistics program. Plasma membrane genes expressed greatly on all of the 15
tumour sample xenografts. The 12 initial patient tumour samples were ranked
from highest to lowest expression. The predicted value of every one of the 55
genes characteristics of low-burden metastatic cells was worked out by
Kaplan–Meier analysis.
All solid tissues and the brain were dissociated for FACS. The tissues were
cut up and placed in culture medium. They were then broken down for 45 min at
37 °C. The suspensions that arose were then inserted into a solution of DNase
for 3 min at room temperature, after which they were washed and dissociated
again. After this peripheral blood, supernatant and bone marrow were collected,
cells were pelleted for 5 min and leftover erythrocytes in peripheral blood,
lung and tumour samples were lysed for 5 min at room temperature. All unused
samples were directly filtered and stored by freezing them in liquid nitrogen.
The tissues from the reduction mammoplasty were washed three to five times,
cut into small fragments and digested overnight in a solution. The digested fragments
were then pelleted for 3 min, frozen and then stored in liquid nitrogen.
The antibodies for several particular human antigens were bought
commercially. Both human and mouse antibodies were stained. After 15 min of
lying on ice, the stained cells were washed to get rid of excess antibodies and
put back into the medium. The cells were then flow sorted and analysed. Dead
cells were eliminated and contaminating human or mouse haematopoietic and
endothelial cells were excluded. The complete tissue sample in the single-cell
multiplex qPCR experiments was run through the flow cytometer. A steady number
of live cells were found in the tissues of all of the animals. The results of
mice which deviated by more than one standard deviation were excluded from the
Single-cell gene-expression experiments were carried out with microfluid
chips. Single cells were sorted using FACS into distinctive wells. The
experiments were done according to protocol. Each well was prefilled with a
solution. After the sorting process, the PCR plated were frozen and or placed
into the thermocycler to go through the process of combined reverse
transcription and target-specific amplification. Exonuclease reaction solution
was subsequently added to remove unincorporated primers. Each well was then
diluted. A bit from each sample was then dropped into a separate plate and
mixed with another solution. Individual primer assay mixes were made in yet
another plate. The chips were primed before the samples and assays were mixed
into them. The chips were then evaluated thoroughly.
All of the single-cell PCR data were analysed using a statistical analysis
software. In its entirety, 268 mammary cells from reduction mammoplasties as
well as 441 metastatic and 523 primary tumour cells from the xenografts of the
mice were analysed. The results of the analyses were developed into Ct values,
which were then further generated into statistical language.
In regular mammary cell experiments, the Ct values were standardized by
deducting the average value of the basal/stem-cell population per gene and per
array. In the mice xenograft experiments, the Ct values were standardized by
deducting the average primary tumour expression per gene as well as the average
value of the basal/stem-cell population per gene and per array. Low quality
samples were found and withdrawn from additional analysis.
Various statistical tests were performed in order to determine gene
expression differences between earlier established populations. For regular
mammary cell experiments, a threefold comparison was initiated between
basal/stem, luminal, and luminal progenitor cells. This generated an array of
49 differentially expressed genes. To find out of which population each gene is
an aspect of, pair-wise tests were executed. When comparing metastatic cell
experiments to that of primary tumour cells, only the pair-wise tests were
executed. Threefold comparisons were executed to compare lung metastatic cells
from the three xenografts from the mice and fivefold comparisons were executed
to compare metastatic cells from each tissue. These analyses were done with a
variety of statistical programs.
In order to find passages which were represented in a greater fashion in
the set of significantly differentially expressed genes that they would have
been by just chance, an enrichment analysis of Biological Process gene ontology
terms was executed using several statistical programs.
For both histological analysis and immunofluorescent analysis, the tissues
were suspended overnight in paraformaldehyde and processed paraffin embedding.
The tissues were stained with haematoxylin and eosin for histological analysis.
In order to commence the immunofluorescent analysis, the tissues were stained
using immunofluorescent staining. The immunofluorescent staining was used upon
lung tissues with low and high metastatic burden.
On the sections with paraffin-embedded tissue immunostaining was carried
out by using a citrate buffer and heating the sections in a pressure cooker for
8 min. Several human genes were stained with the help of a three-step method.
First, the primary antibodies were incubated overnight, which was then followed
by one-hour incubations along with detecting antibodies after which a
fluorescent binding biotin was added. MYC and phospho-histones were found by
following a two-step method, in which the overnight staining of antibodies was
followed up by a one-hour incubation along with detecting antibodies. The
number of positive nuclei was counted for tumour, high burden, and low burden cells,
after which the significance was calculated by a statistical analysis software.
Metastasis is a process in which cancer cells spread to other sites within
the body. Metastatic cancer, also known as advanced cancer or stage IV cancer,
is defined as the spread of cancer from a primary tumour to the rest of the
body. This type of cancer is the main cause of fatality (about 90% of deaths)
in cancer patients due to the fact that it cannot be fully cured.
In order for metastasis to develop the cancer cells must first break away
from the primary tumour and travel through the circulatory and lymphatic
systems. Then it must avoid being destroyed by immune attacks initiated by the
white blood cells and erupt at beds of the capillary kind. After this, the metastasis
can infest into distant organs and proliferate. Metastatic cancer cells also
have the ability to create a new environment in which harmful secondary tumours
can cultivate.
While it is still unknown what exactly the origin is of these metastatic
cancer cells there definitely have been multiple hypotheses made about this
exact question. Many hypothesise that metastatic cells emerge during a process
in which epithelial cells go through a number of gene mutations which
eventually transforms it into a mesenchymal tumour cell. Other theories state
that metastatic cells stem from several collections of stem cells. Another
theory prevails that tumour-associated macrophages are the primary cause of
metastasis, due to the fact that it has the ability to set up a pre-metastatic
alcove and encourages tumour inflammation. The last theory states that
metastatic cancer cells appear due to inability to take up enough oxygen and/or
expel enough carbon dioxide in myeloid cells.
Metastatic cancer doesn't just spread sporadically, instead, depending on
the type cancer, it will spread to specific sites in the body. For example,
with breast cancer the metastasis has the urge to spread mostly to the liver,
lungs, bones, and brains, while pancreas cancer has the tendency to spread to
the peritoneum, lungs and liver.
While metastatic cannot be cured yet, it can be treated in order to prolong
the life of the patient and improve their wellbeing. Typically this treatment
aims at slowing the growth of the metastasis and relieving the symptoms the
patient may experience due to the metastasis. The type of treatment depends on
the type of cancer, the size of the metastasis, where the metastasis started,
the location of the metastasis and several other factors that may intervene
with the condition of the patient or the metastasis.
Treatment for metastatic cancer typically includes systemic therapy or
therapeutics which are ingested or injected into the bloodstream. The most
common form of these therapeutics is chemotherapy or hormone therapy. Other
treatments to reduce the effects of metastasis are treatments such as radiation
therapy, biological therapy and/or surgery.
Breast Cancer to the Brain: A Clinical Primer for Translational Investigation
treatment for primary breast cancer becomes more and more effective there is a
lack of clinical advancement in the area of brain metastasis from breast
cancer. In order to broaden the spectrum of brain metastasis treatments, we
must first focus on the subtype of breast cancer, the evolution of breast
cancer subtypes as metastases form, and the general medical condition of the
for brain metastasis are currently scarce and not effective enough with a
maximum life expectancy of 16 months after the start of the treatment. While
surgically removing any lesions will definitely improve the patient's
condition, there is a large chance of tumour recurrence unless the surgery is
followed up with radiotherapy. While radiotherapy is successful in targeting
and removing cancer cells throughout the whole brain, there have been reports
of significant cognitive decline due to the exposure of radiation to the brain
tissue. Lastly, while medical therapeutics may have the ability to rid of
cancer cells with little to no harmful side effects many chemotherapeutic
agents are unable to pass the blood brain barrier and reach the tumour.
In conclusion, in order for brain metastasis to be more
successfully treated we must focus on discovering new therapeutics that can
cross the blood brain barrier and target tumour cells.
Jammed Cells Expose the Physics of Cancer
In 1995 Peter
Friedl had a startling discovery: coordinated cells which the had been growing
in his lab started clustering together and started moving through a network of
fibers which were meant to mimic the human body.
His discovery
was important for the research about jamming, a process where different cells
pack together so tightly that they become one unit. Cells in a tumor or tissue
can change their own mechanical properties because of their mechanical
microenvironment, using genetic programs and other feedback loops, and if
jamming is to provide a solid conceptual foundation for aspects of cancer, it
will need to account for this ability.
Theories for
how cancer might behave mechanically have only been researched as theories for
solids or theories for fluids, however a small group of scientists have
suspected that a combination of sticky epithelial cells, which make up the bulk
of solid tumors, and thinner, more mobile mesenchymal cells that are often
found circulating solo in cancer patients' bloodstreams could cause a phase
transition . Scientists also found that a phase transition between jammed and
unjammed states could fluidize and mobilize tumor cells as a group without
requiring them to transform from one cell type to a drastically different one.


text:
End Of Giroud? Arsenal Official Arrive Club To Seal Deal For Goal Poacher
Despite being heavily involved in the summer transfer window, the Gunners are yet looking to secure the future of the club.
Arsenal have reportedly sent scout to watch Celtic international Moussa Dembele, while they have also retained interest in Germany international Marco Reus.
Dembele was impressive for Celtic on Wednesday night when they hosted Manchester City in the Champions League at Celtic Park. Dembele scored a brace on the night.
Arsenal are not left alone in the chase of the player, Real Madrid, Bayern Munich and Tottenham are all keeping tabs on the player, and the report claims Arsenal "could make a January move" for him.
but Hoops boss Brendan Rodgers has made it clear he intends to hold onto the French forward.
He said: "We're fortunate to have him. He was coveted by a number of teams but his agent is a clever guy.
"Does he go to a so-called better league and sit on the bench and not get so many games?
"Or does he come to a big club with an opportunity to develop and invest some time into his development, and then step up if that's what he wants to o?
Wenger has left Giroud on the bench more often than not this term and his recent preference for Sanchez in attack means Giroud might be ousted sooner.

subset: commoncrawl


text:
Mashable has given our first look at the LEGO Jurassic World Raptor Rampage (75917) set in anticipation of the 2015 New York Toy Fair tomorrow. There's no mentioning of piece count but the set does include Owen, Claire, a park ranger, and two Velociraptors named Blue and Charlie. The set will retail for £49.99.
Home LEGO Jurassic World LEGO Jurassic World Raptor Rampage (75917) First Look


text:
https://www.kingsporttn.gov/wp-content/uploads/logo-1.png 0 0 WP Admin https://www.kingsporttn.gov/wp-content/uploads/logo-1.png WP Admin2015-03-31 02:49:142016-09-20 10:33:47Southbound lane of Fort Henry Drive closed tomorrow
KINGSPORT – The southbound lane of Fort Henry Drive heading towards Colonial Heights will be closed on Tuesday, March 31, 2015, from 8:30 a.m. to 3 p.m. to allow for a water line valve repair. The closure will be near Murphy Oil Company, between South Road and Thornton Drive. Motorists are urged to take caution and plan ahead, avoiding the work zone entirely if possible.


text:
Norway mass killer faces last hearing before trial
The right-wing extremist who confessed to a bombing and mass shooting that killed 77 people went before a Norwegian court Monday in the last scheduled detention hearing before his trial.
Unlike the only previous public hearing, Anders Behring Breivik this time agreed to let himself be photographed before the proceedings began.
A live broadcast by Norway's NRK TV showed the 32-year-old Norwegian - dark suited, hands in cuffs and smirking - being led into the court room. As he sat, Breivik pulled a piece of paper from his right jacket pocket, apparently with notes he had prepared for the hearing.
About 100 survivors and relatives of the victims of the July 22 massacre attended the hearing in Oslo's district court - expected to decide to keep Breivik in jail until his trial begins in April.
Breivik has admitted he carried out the bombing outside the government headquarters in Oslo and the shooting massacre at a Labor Party youth camp on Utoya island, outside the capital.
But he denies criminal guilt, saying he's a commander of a militant organization aiming to overthrow European governments and replace them with "patriotic" regimes that would deport Muslim immigrants.
Police have not found any trace of his supposed network of "Knights Templar" and say Breivik carried out the attacks on his own.
A psychiatric evaluation has found him criminally insane. He has refused to cooperate with psychiatrists working on a second, court-ordered evaluation of his mental health.


text:
Year 6 Objectives
On this page you will find the Year 6 age related expectations. We will be working hard to meet these objectives throughout the year.
If you would like to discuss any of these objectives, or things that you can do to help your child meet them, then please feel free to pop in. We are more than happy to provide paper copies if you would prefer.
I have also attached examples of the SATS tests from 2016 incase they are of interest to you.


text:
Jeans are an important part of any guy's wardrobe. They can take you from a casual outing with friends or a fun date to a day at the office. Finding the right fit and wash in your jeans is an important part of the shopping process because it will ensure that you have a pair of flattering pants. Use these tips to find a great pair of jeans for every occasion.
Choosing Jeans
1. Figure out which cut fits you best
Men's jeans come in many different cuts, which allow you to pick a style that's best for you. Men's bootcut jeans are cut slightly larger at the leg opening and are flattering on most men's body types. Men's skinny jeans fit very tightly from the waist to the ankles and are typically most flattering on lean body types. If your body type is average to muscular, relaxed fit jeans will fit well. Straight cut jeans are simple and fall straight from the hip to the floor, making them an excellent choice for men who want a flattering style without a lot of embellishments.
2. Choose a wash
Look for stonewashed jeans and shades of dark blues or muted greys, which look classic and go with everything. Keeping a few pairs of timeless jeans in your wardrobe is a good idea, and it allows you to buy jeans in trendy colors and washes, such as dirty washes and acid washes, to keep up with current styles.
3. Look carefully at details
Many premium denim jeans, or designer jeans, are designed with detailing on the back pockets and features such as flaps and deep front pockets. Men's straight jeans look classic with stitching on the back pockets. Pockets with screen printed images or lettering can give you a more urban, fashion-forward look.
4. Consider the length
Think about which shoes you will primarily be wearing with your jeans. Straight cut jeans and relaxed fit jeans look great with athletic shoes, while bootcut jeans and premium denim jeans look great with dressier shoes and low boots. If you have the shape to pull off men's skinny jeans, try them with vintage-style shoes or designer sneakers.
5. Comfort should come first
Whatever you decide about cut, fit and color, find a pair of men's jeans that are comfortable enough to wear to casual events and evenings out. If you find the right style, your jeans will be the clothes you reach for over and over again.
Straight talk on men's straight fit jeans Men's straight jeans look grea...
Boyfriend denim - They rock! They're super comfy and stylish. You can buy t...
Wear jean to work now become more popular than ever, casual Friday seems to...


text:
"Penguin Random House has asked Rabbi Baroness Julia Neuberger to independently review one of its books, Pedro Baños's How They Rule the World, after allegations of antisemitism made against the author continue to grow."
Penguin have published Deborah Lipstadt. Apparently, in this case it's a question of some passages about the Rothschilds (a European banking family) and a famous cartoon of an octopus. However, you can imagine the effect such reviews would be likely to have on publications about the holocaust that contained material sympathetic to revisionism. I'm not aware of any such, beyond some dark remarks by David Irving, but these processes in the publishing industry are often behind closed doors. Sometimes there are references to them in the prefaces to books. It would be an interesting subject of inquiry in itself.


text:
Daniel Craig Lied About James Bond Return Just Hours Before Confirming News to Stephen Colbert
Daniel Craig confirmed what fans had long suspected in an appearance Tuesday night on The Late Show With Stephen Colbert: He will reprise his role as James Bond for a fifth—and final—time.
But as Colbert fawned over the British actor's portrayal of 007, calling him the "greatest Bond," Craig said he had "to apologize to all the people I've done interviews with," because, while promoting his new movie Logan Lucky in New York earlier in the day, he lied about his future as the franchise. Or, to use his words, he was "cagey" and "coy."
Craig has, in fact, been signed up for the untitled Bond 25 for a "couple of months," he told Colbert. The reason he withheld the news from other journalists, he claims, is because he wanted to share the news directly with the Late Show host. Sure, it's pretty smart to save the big announcement for a popular late-night talk show, so it has maximum impact. But you have to feel for the other poor souls who tried to get the scoop.
Earlier Tuesday, speaking to Boston's Magic 106.7 radio station, Craig said, "No decision has been made at the moment," though he later told Colbert it definitely had.
"There's a lot of noise out there, and nothing official has been confirmed, and I'm not, like, holding out for more money or doing anything like that," Craig said. "It's just all very personal decisions to be made at the moment. I know they're desperate to get going, and I would in theory love to do it, but there is no decision just yet."
The New York Times first reported that Craig would return as Bond in July, after Sony and Eon Pictures announced that the 25th film in the spy series would be released in November 2019. The announcement made no mention of who would star, nor did it confirm who would direct. At the time, spokespeople for Craig did not issue comment to Newsweek or the multitude of other publications that requested confirmation.
There was also silence from Craig's reps in August after cable network Showtime's president, David Nevins, let slip that the actor would reprise his most famous role.
Nevins told reporters Craig's miniseries for the premium channel, Purity, may not film until 2019—after he completes Bond. "He's doing Bond first, and I can't say anything about what I know or don't know about Bond, [but] it's possible it may not shoot until 2019," said Nevins.
Cloak-and-dagger tactics are part of the process of making films and television, and when done right, they can keep fans in anticipation for where the story goes next—like when Game of Thrones killed Kit Harington's brooding Jon Snow. Harington spent a year insisting he really had left the show, only to be resurrected in Season 6. But in Craig's case, was the subterfuge really necessary?
Perhaps Craig can be forgiven if Bond 25 is as good as 2012's Oscar-winning Skyfall.


text:
- Home /
- Instruments /
- Fiddle /
- Martin Hayes & Dennis Cahill - Live In Seattle
Ireland celebrated fiddler Martin Hayes and American guitarist Dennis Cahill have captured the excitement of their shows on this album. Recorded on January 31st 1999 at Seattle?s premier folk/acoustic club, the Tractor Tavern. So what's all the fuss about? Mainly, I think, the fact that both players put so much of themselves into the music. Call it soul, heart or any other bit of anatomy, you can hear that this music is full of it. There are only five tracks on this CD, but every one is captivating. Even the monster 27-minute medley indulges the audience more than the performers.
- Home
- Instruments
- Groups & Bands
- Songs
- Others
- Claddagh Label


text:
ED SHEERAN Writes 3 Songs For WESTLIFE's 2019 Album Because He's A Big Fan!
Renuel Fallore
Posted at
The lovable lads of Westlife are back to colour our worlds with their first single after eight years—"Hello My Love"—which was co-written by Ed Sheeran!
VJ Ai dela Cruz recently flew to Singapore for a MYXclusive interview with Shane Filan, Nicky Byrne, Kian Egan, and Mark Feehily who, after disbanding in 2012, explained how their much-awaited reunion happened and what their "big fan" Ed's role was in their decision.
"Myself and Shane had dinner with our wives in Christmas two years ago and we just got to talking about Westlife and the history, and some of the memories... We both probably came away from that going, 'I wonder when we'll ever do it again,'" Kian started his story.
But according to the The Voice of Ireland coach, it was only a year later that "the stars aligned" and they had their first group meeting in Nicky's house to talk about the possibility of doing Westlife again.
Coincidentally, they got word that Steve Mac—writer and producer of most of the Irish band's earlier hits like "Swear It Again" and "World Of Our Own"—has finished writing new Westlife songs with Ed Sheeran, whom he has previously collaborated with for the 2017 most-streamed, best-selling, and Grammy-winning song, "Shape Of You."
"We found out that Ed Sheeran had written some Westlife songs without even knowing that Westlife were talking about getting back together because he loved Westlife when he was a little boy. So it was kind of like all these things kind of happened and the stars aligned, as we would say," Kian explained.
Mark further shared that "Hello My Love" (which you can check out here) was among the first three songs they've recorded for their upcoming album—all of which were written by Steve and Ed, who revealed that he actually learned how to play the guitar to Westlife's first greatest-hits album Unbreakable.
Get to know more about Westlife's reunion and their collaboration with Ed in the MYXclusive video below!


text:
For the reasons mentioned above, dreaming of bandages can be a hard thing to provide a definition for.
On the one hand, bandages are a great way to make sure that you keep yourself healthy after getting a wound. While that cut may not look bad at first, if you let it go untreated, it could become infected, and if it becomes infected, then something terrible could happen causing you to go to the doctor eventually, all over a little scratch. You do not want this to happen. Therefore if you have a dream about bandages this could be a way of recalling your health.
This health could be related to anything in your life. You could be a physically sick person that constantly needs treatment, and the bandages would therefore present themselves as a representation of your desire to not be so sickly. You could be having a dream of bandages because you have gotten many emotional wounds too. Perhaps someone has hurt you in the past by breaking your heart or by calling you names or leaving you bereft at a very critical point in your life. If this is the case then you would be dreaming of bandages because you have a need to heal emotionally. Do not discount emotional wounds; they can sometimes hurt more than physical ones do.
Sometimes when you have a dream of bandages what you are really trying to express is the amount of pain that you feel. If you see a plethora of bandages around you, but not on you, then you should question why, in your dream, that you are seeing so many bandages. In a dream, nearly everything that you remember the morning that you wake up is a symbol. If you remember bandages very well, then think to yourself about what kinds of wounds you might have and why you might need a bandage, metaphorically or physically speaking.
If you have bandages on but do not have a wound, then this could be a sign that you are becoming a bit of a hypochondriac. You care a little too much about the state of your health when it turns out that most of the time you are totally fine. Do not fall into this trap or let yourself get too carried away over nothing. You do not need to wipe down every doorknob before you turn it and you do not need to wash your hands every time you shake someone else's hand. Take some responsibility and realize what health measures are important for you to take and which ones are completely unnecessary. A dream of a bandage can also present itself as something of a mental security blanket. You feel as if you need a little extra care for yourself even though this is really not the case. Do not baby yourself because it is one of the most compromising situations you can be in, and you should be putting yourself in it. Do not fall into this trap or things will only get worse for you.


text: Sunshine elasticated bookmark - LAST ONES! Fabric elasticated bookmark in bright sunshine design £2.00 Quantity: at £2.00 each Add To Basket 1 in stock. Fabric bookmark with elastic to keep hold of the book securely. Sun design on a vibrant yellow background. Limited edition! Ready to post within 1-3 working days.


text:
Renée Hollis is an author, photographer and organizer of collaborative projects for creative artists. Her goal with 'Timeless Wisdom' is to create an opportunity for writers to share a powerful message with thousands of readers and contribute to be a highly collectible, beautifully produced series.
Fear and Courage
USD $24.99 Tax Included
True Stories That Reveal the Depths of the Human Experience
We have all felt fear, whether it's our racing heart as we make a speech or the profound awareness of our own mortality as we await medical results.
Of course, the flip-side of fear is courage, as Nelson Mandela famously said, 'I learned that courage was not the absence of fear but the triumph over it.'
25 true stories capture the full range of the fear and courage experience in the second book of the 'Timeless Wisdom' Series. At times humorous, often poignant, these stories shine a light on just what it means to be human.
SPECIFICATIONS: 9781925820065 | Hardback | 227 x 170 mm / 9 x 6.75 inches | 232 Pages
The 'Timeless Wisdom' series showcases a diverse range of true stories collected from around the world, all contributed by mature writers as part of an international competition. Interspersed between the stories are memorable quotes touching on each book's theme. The resulting books are inspiring, surprising and profoundly enriching.
The Senior
"Features 25 true stories from people from all over the world, all of whom are aged 65 or older.. Sometimes funny and often poignant, the book features stories bound to linger in the mind long after reading. " Click here to read in full
National Seniors Australia
"Read real life stories from everyday people who have done extraordinary things" Click here to view
There are no reviews yet.


text:
We hardly ever read about the veteran actors in the media and what they are up to! He is one of my personal favorites and has done quite well for himself over the years. His brother who was the king of being villains , the late 'Amrish Puri' was seen in many classics and now his brother is once again coming back to the screens! The veteran actor Om Puri who was an integral part of 1990's super hit film 'Ghayal' starring Sunny Deol, will also be part of its sequel 'Gayal Once Again'.
Recently the actor was spotted shooting for the film in Bandra along with Sunny Deol. A source close to the unit says,
"Om Puri sir is playing a pivotal role in the film. He has started shooting for the film already. Sunny and Om Puri were seen having intense discussion during the shoot. Om Puri Sir hasn't read the script and all he we reveal is that the police officer has retired now but still shares a warm relationship with Sunny's character".
Ghayal Once Again will be Directed and Produced by Sunny Deol under the banner Sunny Sounds Pvt Ltd!


text:
When in Manila, you'll realize just how religious this nation is, but you probably won't find a lot of people who can express their faith the way Creed does.
I've been a huge fan of Creed since I was a wee 10-year-old boy, who happened to be channel surfing and stumbled upon the music video of a song called With Arms Wide Open. Little did I know that that song got nominated in 2001 for a Grammy for Best Rock Song and that that song would open the doors to a fandom that would last over twelve years (and counting)!
When I found out that Creed was coming to Manila, I knew I could not pass up the chance to see them up close and personal. As soon as I could, I started finding any and every way possible to get myself an opportunity to be in the same room as one of my favorite bands of all time.
Of everyone in the Emerald Function Room at Crowne Plaza, I was probably the most excited, psyching myself by naming every Creed song that played within the first strum of the first chord just to prove to my friend Marji how big of a fan I was!
When they finally entered the function room, they were as low-key as low-key can get. They weren't your typical rock stars despite the mullets and the tattoos that they sported. The only reason they stood out from everyone else was because they were American and that the spotlight was on them. Other than that, they had no rock star attitude whatsoever.
Even when they spoke, you could feel that these guys were very humble and down-to-earth. Despite his powerful voice when he sings, vocalist Scott Stapp sounds like one of the most gentle individuals I've ever had the pleasure of sharing a room with.
Scott Stapp (vocals)
Bassist Brian Marshall was all smiles and was very candid throughout the press conference.
Touring guitarist and backup vocalist Eric Friedman
Lead guitarist Mark Tremonti (left) and drummer Scott Phillips (right)
It was interesting hearing them talk about drawing from their real-life experiences and their faith in God as sources of inspiration for their music. Vocalist Scott Stapp mentioned that the most exhilarating songs to perform are always My Sacrifice and One Last Breath because of the fans who seem to know every word and every note.
But the best part was definitely getting the chance to go up and introduce myself to the band whose music I grew up listening to! Going in, I had no idea I would be able to get to take photos with the band, let alone shake their hands!
I was at a loss for words.
You have got to love how game these guys were for everyone who went up on stage to pose for a photo with them.
I was obviously a happy camper.
After that photo was taken, I told them how much I was looking forward to their show the next night. I then spent the next hour soaking myself in the pure joy that comes from meeting one of your favorite bands in person. Things like this only happen when you're in Manila.
With photos from Marji Manlunas
Creed's press conference in Manila was held November 10, 2012 at Crowne Plaza. Creed: Live in Manila was brought to you by CNCA Media Concepts, Inc.
Creed Press Conference in Manila[fb_instant_article_ad_01]?


text:
Stir-Fried Chicken and Bok Choy is an easy stir fry recipe that only requires 15 minutes to make! This Asian inspired main course stir-fry that is full of veggies and a sweet and spicy sauce. This dish is full of flavor, yet light on the waistline!
If you love this simple Bok Choy Stir Fry, you will also love Simple Chicken Asparagus Stir Fry, Easy Fried Rice, and Orange Chicken.
Stir-Fried Chicken and Bok Choy
Bok Choy is popular in Asian cuisine and is absolutely delicious when stir-fried.
Paired with chicken, carrots and a slightly sweet and savory sauce, this stir fry, is one easy meal that packs in a lot of nutrition and flavor!l
What is Bok Choy?
- Bok choy is a member of the cabbage family and is has high amounts of nutrients, antioxidants, and Omega-3s.
- It is high in fiber and low in calories. (9 calories per cup!!)
- Bok Choy is especially rich in vitamin C, vitamin A, and vitamin K.
- For a vegetable, it is a great source of calcium, folate, and magnesium as well.
Bottom line–bok choy just tastes good and is versatile. I love sautéed bok choy, but it is is delicious as part of this stir fry as well. Grilled bok choy is fabulous as well. But if you can not locate in your store, feel free to use napa cabbage in place of the bok choy.
- Chicken--boneless, skinless chicken breasts or thighs
- Bok Choy
- Carrots
- Green Onions
- Sesame Seeds–for crunch
- Stir Fry Sauce
- Oil–cooking oil with high smoke point like sesame, coconut oil or canola oil.
Note if Using Sesame Oil: Be sure to use LIGHT sesame oil instead of dark sesame oil for this stir-fry–also be sure your sesame oil does not smell rancid before using and store sesame oil in the refrigerator to keep fresh.
Ingredients for Stir Fry Sauce
- Honey– Maple Syrup or brown sugar can be used in place of honey if desired.
- Ginger–freshly grated ginger, NOT powdered ginger
- Garlic
- Rice Wine Vinegar
- Soy Sauce–Be sure to use gluten-free soy sauce or tamari to keep this stir-fry gluten free.
How to Make Chicken and Bok Choy Stir Fry
Step One: Make the Stir-Fry Sauce
- Mix together honey, garlic, soy sauce, and rice wine vinegar together.
Step Two: Saute the Chicken and Vegetables
- Using an oil that has a high smoke point, like sesame oil, coconut oil, or canola oil, saute the chicken over medium-high heat until just browned.
- Add in the bok choy and other vegetables and saute until crisp tender.
- Add in the simple 5 ingredient stir fry sauce and stir it all up.
- Serve.
More 15 Minute Dinner Options
- 15 Minute Skinny Fettuccine Alfredo
- Honey Lemon Chicken Skillet
- Chicken Asparagus Stir Fry
- Easy Vegetable Fried Rice
The next time you are out and see bok choy, grab it and get cooking. In 15 minutes, you will have a tasty dinner that is good for you and easy to prepare.
Stir-Fried Chicken and Bok Choy
- 2 tablespoons honey
- 1/2 teaspoon freshly grated ginger
- 2 cloves of garlic grated or minced finely
- 2 tablespoons reduced sodium gluten-free soy sauce
- 1 tablespoon rice wine vinegar
For the Stir Fry
- 1 teaspoon light sesame oil
- 1 pound boneless skinless chicken breasts, cut into 1 inch chunks
- 1 head of bok choy washed and cut into 1 inch strips
- 2 large carrots peeled in strips or 1/2 cup matchstick carrots
- 5-6 green onions diced
- 1 tablespoon sesame seeds
- 1/4 cup chopped cilantro if desired
- Stir together all the ingredients for the sauce and set aside.
- Heat sesame oil in a large wok or skillet over medium-high heat. Add in chicken and cook for 5-7 minutes. Add in bok choy, carrots, green onions, and sesame seeds. Stir continuously for 3 minutes and then add in sauce. Cook until sauce has coated the chicken and vegetables and heated through.
- Serve with a sprinkle of cilantro and toasted sesame seeds if desired.
- Be sure to use gluten-free soy sauce or tamari to keep this gluten-free.
- Be sure to use LIGHT sesame oil instead of dark sesame oil for this stir-fry--also be sure your sesame oil does not smell rancid before using.
- Sesame oil needs to be kept in the refrigerator to remain fresh.
5 Secrets to Master Your Instant Pot
free email series
Expert Tips to Get More from Your Instant Pot


text:
Welcome to the Talend Data Integration Cloud series. This series was created to give you a solid foundational understanding of how to navigate Talend studio to enhance and publish jobs to then be executed within Talend Cloud.
We will set up Talend Studio to connect with Talend Cloud and explore how to use Studio to take advantage of the cloud environment features.
You will learn how to publish a Job from Studio to the Talend Cloud and how to enhance logging within the cloud for personalized results. We will also explore how to utilize the remote engine to access your on-premises data. Within this series I will be working with a sample project, available for download right from inside the home page of the Talend Integration Cloud web application, here under Samples.
I encourage you to download this sample project and its contents so you can follow along, and to look out for more videos as we continue to highlight Talend Integration Cloud features that will simplify your cloud experience. Let's get started.


text:
Recent Posts
Is Your Sleep Medication Increasing Your Risk for Dementia?
Posted byon
Researchers recently investigated health records of people age 50 years or older who took antidepressants (multiple brands) throughout a 7-year period. They compared dementia risk in 5000 users of trazodone to that of over 400,000 users of other antidepressants to determine if trazodone plays a roll in the development of dementia or cognitive dysfunction.
They found that the incidence of dementia in trazodone users was greater than among people taking alternative antidepressants. The median time to dementia diagnosis in trazodone users was 1.8 years.
According to Tiffany Schwasinger-Schmidgt, MD, PhD, "Tazodone is rarely used to treat depression, but is often used in the management of insomnia. She also mentioned that "depending on what trazodone is prescribed for will determine the dosing, and the dosing will affect the potential for development of dementia in patients."
This study lends evidence to the theory that trazodone may be a contributing factor to the development of dementia.
The study was published online February 5 in PLOS Medicine.
Related: Sentra PM (a Medical Food) and Trazodone in the Management of Sleep Disorders


text:
- Remove this product from my favorite's list.
- Add this product to my list of favorites.
No products
0,00 € ∑ Products
tariff selected in checkout + plus S&H
if applicable + German VAT
0,00 € = Total
IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).
Recombinant Human IL2RG /CD132 Protein, with C-Fc Tag (rhIL2RG Fc Chimera) Leu 23 - Asn 254 (Accession # AAH14972) was produced in human 293 cells (HEK293).
Molecular Characterization
rhIL2RG Fc Chimera, fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 53.5 kDa. The predicted N-terminus is Leu 23. DTT-reduced Protein migrates as 80-90 kDa due to glycosylation.
Less than 1.0 EU per μg of the rhIL2RG Fc Chimera by the LAL method.
>98% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.
See Certificate of Analysis for details of reconstitution instruction and specific concentration.
Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).
(1) Kondo M., et al., 1993, Science 262:1874-1877.
(2) Russell S.M., et al., 1993, Science 262:1880-1883.
(3) Noguchi M., et al., 1993, Science 262:1877-1880.
Recombinant human IL2RB /CD122 Protein, Fc Tag, 50µg - 420,00 €
Recombinant human IL2RG /CD132 Protein, Fc Tag, 10x 100µg - 1 650,00 €
Recombinant Human IL-2 R alpha / CD25 Protein, Fc Tag,100µg - 312,00 €
Recombinant Human IL-2 R alpha / CD25 Protein, His Tag, 100µg - 348,00 €
Welcome Login
Contact us
Phone+49 561 804-4668


text:
Why You Should Include Garage Doors When Installing A Home Security System
When people come up with installing a burglar alarm system to their homes, they frequently consider putting alarms on more obvious openings, such as doorways, windows, and other noticeable openings in the house, such as garage doors. Garage doors, in particular, have an open and shut mechanism that serves as the opener. Because of this, a lot of people believe that this type of doorways has no risk of being


text: Hi guys/grrls! Kevin wrote: >Or you can probably right click on the link, and say >"open it in a new window" so it has its own window >and isn't stuck in another frame. ANY time you get >stuck within frames from a site that annoyingly keeps >you in or the web programmer didn't know enough to >send you out of, you can do that trick & then just >close your original window. Unfortunately, this didn't work with Hotmail. (Hotmail is from Microsoft, you know.) Uh, it still sticks you within frames ... Gary wrote: >Right click and then gurble garble froggin' fretzen >garber muckle. Unfortunately, this didn't work either ... See you. Eric _______________________________________________________________ Get Free Email and Do More On The Web. Visit http://www.msn.com


text:
Personal data refers to data, whether accurate or not, about an individual who can be recognized from that data; or from that data and former information to which the organisation has or is expected to have access. Personal data in Singapore is protected in the Personal Data Protection Act 2012 (PDPA).
Data protection courses equip professionals, managers and executives (PMEs) in Singapore with new competencies using a sensible approach and borrowing from best practices, showing them how to put into practice, meet the terms and to stay in line with the PDPA.
Nevertheless, can it really help businesses? How?
Here a very high-level listing of those reasons, so that everybody can profit from realizing that addressing privacy inside any kind of organization, and inside all services and products that touch personal data in any way, brings a lot of business values, and should not be brushed aside or minimized insignificance.
To Meet Compliance Needs
This is the advantage that is most frequently touted, so I'll start with it. Organizations that do not put into practice privacy protection face enormous fines in the tens of millions of dollars and up to 20-year penalties for non-compliance with laws, regulations, standards and their own published privacy and safety notices. Organizations also risk losing valuable business affairs by not complying with their contractual needs for privacy protections.
To Stop Breaches that Hurt Businesses
A privacy concept that is common to all global privacy principles, and a requirement in all data safety and privacy legal requirements is implementing strong security safeguards to look after personal data. Organizations that put into action such controls will, as a result, trim down the number of security incidents that result in privacy breaches. Fewer breaches mean that the business does not lose trust, then resulting lose clients or other types of business. It also means that the business does not have to deal with fines, multi-year penalties, or civil suits as an aftereffect of the breach.
To Avoid Data Breaches
Privacy protections involve ensuring strong safety for personal data and all the connected activities concerned with collecting, storing, accessing, transmitting, processing, sharing and disposing of the data. Traditionally organizations have not had inclusive, strong data security controls implemented all through the whole enterprise, through to every end-device. By enforcing security controls for personal data, breaches that negatively impact the data subjects will be avoided.
To Keep and Improve Brand Value
A Forbes Insights study showed that 46% of organizations suffered harm to their reputation and brand value as an effect of a privacy breach. Organizations that plainly makes clear that undergoing data protection courses and protecting the privacy of their clients is their primary objective care about their customers' privacy, will build emotional relations to their brand, which will improve brand value.
To Support Ethics
Most organizations have well-known business ethics policies or a code of ethics. Even those that have not still need to follow ethical practices if they expect to stay in business for any length of time. Such ethics policies normally indicate something to the effect that confidential information will be handled correctly, not used in activities in ways that can do damage as a result, and used only as indicated for business purposes.
To Preserve Public, Investor, and Customer Trust
According to a Ponemon study specially made by Centrify, 65% of persons whose private data was breached lost trust in the organization that qualified the breach. One in four people breached took their business somewhere else. Organizations that do not apply privacy protections, and subsequently experience breaches, will lose trust, which in turn will result in lower profits and fewer clients.
To Support Your Customers' Needs
The public is much more privacy-aware now than before. And, as our youngest population learn more concerning privacy all throughout grade schools and high schools, they are having bigger expectations, even before adulthood, that they have growing rights over how their own personal data is collected, used, studied, analyzed, and shared. The public is becoming extra aware of all their growing rights to tell those that gather their personal data that they anticipate having their personal data protected, and have the rights to open and control their personal data
To Support Innovation
Too many people claim that building safety and privacy controls into new technologies, products and services stifle innovation. That is absolute hogwash! In reality, when privacy is persistently addressed inside new innovations, it expands and improves innovations. It does not restrain them. The public is challenging that privacy is protected. Privacy has to be viewed as not just a differentiator or rather be done if lawfully required, but a standard necessity for any new technology or service involving personal data. It takes more modernization to create safe privacy-protecting devices that alleviate privacy risk than it does to just leave out such controls.


text:
As the Southern Utah University (SUU) struggled with their data protection system, due to their infrastructure becoming heavily virtualized, Catalogic assisted in building their new system to make VM backup and restore fast and easy, while providing more space in their data center.
Categories: Data Backup, DPX
Backup is something I take seriously; I have been working as a data protection specialist now for over 13 years. Therefore, this month's World Backup Day is something I feel passionately about and is something I want to see people embracing. Especially now, with so many lives and businesses turned upside down, having a backup of what's most important personally and professionally is vital.
Categories: Data Backup
We live in a data-driven age where data is the lifeblood of organizations. Due to this, cybercrime is skyrocketing, cybercriminals seek to exploit human or security vulnerabilities in order to steal passwords, data or money directly.
Categories: Data Backup, Data Recovery
Over the last decade, the hypervisor market share has been dominated by VMWare and Microsoft Hyper-V, but with the emergence of several other competitors, there may be a shift in the landscape. As more organizations make the switch to one of these other hypervisors, protecting the VMs in these alternate hypervisors has become a notable problem. In this article, Brian Sietsma, Solutions Architecht at Catalogic, explains how vProtect can be used to fill this gap.
Categories: Data Backup, vProtect
Learn how a major technology company moved away from VMware to oVirt to reduce costs, and then switched from Bacula to vProtect for a better data protection solution. vProtect cut backup times in half and offered a much easier to use interface.
Categories: Data Backup, vProtect
The developers at Storware never rest on their laurels. The latest release of vProtect – v 3.8, code named Nebula -- comes chock-full of cool new features and updates...
Categories: Amazon, Data Backup, vProtect
It was only three months ago that I blogged about the new vProtect release. And now it's time for another one! Hot from the developers' keyboards comes vProtect v 3.7, the Multiverse release. Why Multiverse? Because it's opening up new worlds.
Categories: Data Backup, vProtect
One of the things we really liked about Storware, when we chose to partner with them, was their aggressive, agile development style. They put out a steady pulse of new releases, adding valuable new features on a (roughly) quarterly basis. And now, only a couple of months after we announced the partnership, we've got a new vProtect release!
Categories: Data Backup, vProtect
Our new Catalogic ECX release 2.6 expanded the application support matrix considerably by adding SQL physical hosts, Epic EHR with InterSystems Cache environments, physical server basic file systems (Windows, Linux, AIX) and VMware pRDMs. On top of all these enhancements, we were also tremendously excited to add support for SAP HANA environments.
Categories: Data Backup, Data Recovery, ECX
Every primary storage vendor offers the ability to snapshot, replicate and/or vault datasets. But when it comes to end users, snapshots are like gym memberships: everyone's got them, but very few use them. At Catalogic, our software is uniquely designed and developed to take advantage of these native capabilities of your storage arrays, but we are aware that (like body types and skill levels) not all snapshots are the same. The technology needs good genes, just as much as good form and the ability to perform and persevere.
Categories: Data Backup, Data Recovery, ECX
Not very long ago, Catalogic and International Data Corporation (IDC) co-hosted a webinar about the importance of copy data management (CDM). Topics of the webinar on CDM included:
Categories: Copy Data, Copy Data Management, Data Backup, Data Recovery, IDC
A data catalog is an invaluable asset to any organization. Let's take a look at what an effective data catalog achieves before identifying the top 5 reasons to implement a data catalog.
Categories: Copy Data, Data Backup, Data Security, Storage Efficiency
A foodservice industry company was facing the challenge, just as many growing companies do, of having to continually expand its IT infrastructure to meet data growth requirements. Starting with 100 TB of primary capacity supporting critical applications such as SQL databases, email, financials, and payroll applications, the company recently added 120 TB of new primary storage and 220 TB specifically for data protection. The company had already made a significant commitment to NetApp for its storage needs and most recently purchased a NetApp Cluster Data ONTAP (cDOT) primary storage system and a secondary ONTAP system for data protection.
Categories: cDOT, Copy Data, Data Backup, Data Recovery, NetApp


text:
IIST B.Tech Admission 2019
April 08, 2019 by Kanica P - Comments(0)
The notification for Indian Institute of Space and Technology 2019 has been released. The registrations for IIST B. tech 2019 will be revealed from 22 May 2019.
• The registration will be in online mode only.
• The last date for the registration will be 5 June 2019.
• The official brochure will be released on 07 May 2019.
• Since there is no entrance examination conducted, IIST B.Tech Admission will be done on the basis of JEE Advanced scores. So, the candidates need to fill the details of their JEE ADVANCED. Keep your JEE ADVANCED details safe for the admission purpose.
• The allotment will be done according to the merit list.
Read the complete article to get more information about this process in detail.
|IIST 2019 B.Tech Admission 2019
|Important Details
|Name of Admission Process
|Indian Institute of Space Science and
Technology B.Tech Admission
|Undergraduate Examination
|Institute Level
|Criteria of Admission
|JEE Advanced 2019 Scores
|Mode of Application
|Mode of Counseling
IIST B.Tech Admission Dates 2019
The admission dates of IIST B.Tech Admission 2019 provide the candidate's information about when the various admission processes will probably be conducted. Since the latest information has not been released as of yet, the candidates can check the tentative IIST B.Tech 2019 admission dates given below.
Admission Dates of IIST B.Tech 2019
|Admission Dates
|Admission Brochure
|May 7, 2019
|Online Application Form
|May 22, 2019
|Final Date for Filling of Application Form
|June 5, 2019
|Declaration of Merit List
|Third week of June 2019
|Choice Filling
|Third week to the fourth week of June 2019
|IIST B.Tech 2019 Seat Allotment
|Fourth week of June to the fourth week of July 2019
IIST B.Tech Eligibility Criteria 2019
All the aspirants must read the eligibility criteria carefully before filling the application form.
1. Citizenship:
• The candidate must be a citizen of India.
2. Date of birth:
• Candidates belonging to general and OBC categories must be born on or after October 1, 1994.
• Candidates who are SC, ST, and PH must be born on or after October 1, 1989.
3. List of qualifying exam:
• Candidates must have passed any of the 10+2 exams.
• Intermediate or two-year pre-university exam conducted by a recognized university/ board.
• The final examination of the two-year course of the Joint Services Wing of the National Defence Academy.
• Senior Secondary School Examination conducted by the National Institute of Open Schooling with a minimum of five subjects.
• The final examination of the 10+2 system, conducted by any recognized Central/State Board, such as Central Board of Secondary.
• Education (CBSE), New Delhi; Council for Indian School Certificate Examination (ISCE), New Delhi, etc. recognized by the Association of Indian Universities (AIU).
• High School Certificate Examination of the Cambridge University or International Baccalaureate Diploma of the International Baccalaureate Office, Geneva.
• General Certificate Education (GCE) examination (London / Cambridge / Sri Lanka) at the Advanced (A) level.
• Vocational Higher Secondary Examination.
4. Percentage Marks in the Qualifying Examination (10+2 or Equivalent):
• Candidates belonging to the general category must have scored at least 75 % aggregate marks.
• Candidates belonging to SC/ST should have scored at least 65% aggregate marks.
• The subjects that will be taken into account for calculating the aggregate marks are Physics, Chemistry, Mathematics, any language and any other subject.
5. JEE Advanced:
• Candidates must clear the JEE Advanced exam.
• General category candidates must score at least 20% marks in JEE Advanced i.e 72 marks out of 360 and at least 6 marks out of 120 in each of the three subjects
• OBC-NCL candidates must score at least 65 marks out of 360 marks and 5 marks out of 120 in each of the three subjects.
• SC, ST, and PD candidates must score at 10% marks i.e. 36 marks out of 360 and 3 marks out of 120 in each of the three subjects.
6. Reservation Criteria:
The number of seats reserved for different categories is
• Scheduled Caste (SC): 15%
• Scheduled Tribes (ST): 7.5%
• Persons with Disabilities (PD): 5% (Horizontal Reservation
• Other Backward Classes (OBC) belonging to Non-Creamy Layer (NCL): 27%
Application Fee:
|Amount (in INR)
|General and OBC
|General and OBC
|All SC, ST & PD
|Male & Female
Contact Details
Indian Institute of Space Science and Technology
Valiamala P.O., Thiruvananthapuram - 695 547
Kerala, India.
Boost your exam preparation to crack competitive exams from all over the world by practicing past papers. Search for your exam and start practicing
Boost your exam preparation to crack competitive exams from all over the world by practicing past papers. Search for your exam and start practicing
Latest News
Scholarlyft Points Ranking
- kamal kant
- 6665 pts
- Narcos Lamidi
- 4680 pts
- Kanica P
- 795 pts
- firstname.lastname@example.com
- 655 pts
- tesyt test
- 480 pts
Search Questions
Search by Past Paper
Search by Mock Test


text:
Hepatitis A
Hepatitis A is an infection of the liver. It is caused by the hepatitis A virus.
This virus is usually found in the stool (feces) of people who have the infection. It is spread by:
- Putting something in your mouth that has been infected with the hepatitis A virus
- Drinking water contaminated by raw sewage
- Eating food contaminated by the hepatitis A virus, especially if it has not been properly cooked
- Eating raw or partially cooked shellfish contaminated by raw sewage
- Sexual contact with a partner infected with the hepatitis A virus, particularly anal sex
Risk Factors
Risk factors for hepatitis A include:
- Having close contact with an infected person although the virus is generally not spread by casual contact
- Using household items that were used by an infected person, but were not properly cleaned
- Having sex with multiple partners
- Having sex with a partner who has hepatitis A
- Traveling to or spending long periods of time in a country where hepatitis A is common or where sanitation is poor
- Injecting drugs—especially if you share needles
- Working as a childcare worker, changing diapers or toilet training children
- Being in daycare centers
- Being institutionalized
- Receiving plasma products (such as people with hemophilia)
Hepatitis A does not always cause symptoms. Adults are more likely to have them than children.
Symptoms include:
- Tiredness
- Loss of appetite
- Fever
- Nausea
- Abdominal pain or discomfort
- Jaundice]]> (yellowing of the eyes and skin)
- Darker colored urine
- Light or chalky colored stools
- Rash
- Itching
- Muscle pain
The doctor will ask about your symptoms and medical history. A physical exam will be done.
Tests may include:
- Blood test—to look for hepatitis A antibodies (proteins that your body has made to fight the hepatitis A virus)
- Liver function studies
- Liver biopsy]]> —removal of a sample of liver tissue to be examined, only done in severe cases
There are no specific treatments. The goals of hepatitis A treatments are to:
- Keep the patient as comfortable as possible
- Prevent the infection from being passed to others
- Prevent more liver damage by helping the patient avoid substances (eg, medications, alcohol) which might stress the liver while it's healing
The disease will usually go away without treatment within 2 to 5 weeks. About 15% of people who are infected by hepatitis A will have relapsing symptoms. This can happen for up to 9 months. In almost all cases, once you recover, there are no lasting effects. You will also be immune to the virus.
In rare cases, the infection is very severe. A liver transplant may be needed.
Proper Sanitary Habits
- Wash your hands with soap and water. This is very important after using the bathroom or changing a diaper.
- Wash your hands with soap and water before eating or preparing food.
Avoid using household utensils that a person with hepatitis A may touch.
- Make sure all household utensils are carefully cleaned
- Avoid sexual contact with a person with hepatitis A.
- Avoid injected drug use. If you do, do not share needles.
If you travel to a high risk region, take the following precautions:
- Drink bottled water
- Avoid ice chips
- Wash the fruits well
- Eat well-cooked food
Immune (Gamma) Globulin
This contains antibodies that provides temporary protection from hepatitis A. It can last about 1-3 months. It must be given before exposure to the virus or within two weeks after exposure.
Hepatitis A Vaccine]]>
This vaccine is made from inactive hepatitis A virus. It is highly effective in preventing infection. It provides full protection four weeks after the first injection. A second injection provides protection lasting up to 20 years.
The vaccine is also used after exposure. If given within two weeks, it can prevent infection.
The vaccine is recommended for:
- People who have a chronic liver disease (including hepatitis C) or a clotting factor disorder
- People who have close physical contact with those who live in areas with poor sanitary conditions
- People traveling to countries where sanitary conditions are poor
- Children who live in areas that have repeated hepatitis A epidemics
- People who inject illicit drugs
- Men who have sex with men
Check with your doctor to see if you should receive the vaccine.
American Liver Foundation
Hepatitis Foundation International
Canadian Institute for Health Information
Canadian Liver Foundation
Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov .
Hepatitis A: questions and answers. Immunization Action Coalition website. Available at: http://www.vaccineinformation.org/hepa/qandavax.asp . Updated May 2008. Accessed January 21, 2009.
Hepatitis Foundation International website. Available at: http://www.hepfi.org .
The Merck Manual of Medical Information . Simon and Schuster, Inc.; 2000.
National Digestive Diseases Information Clearinghouse website. Available at: http://digestive.niddk.nih.gov/ .
Last reviewed January 2009 by ]]>David L. Horn, MD, FACP]]>
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © 2007 EBSCO Publishing All rights reserved.


text:
OHL Press Release
The Plymouth Whalers announced today that 15-year-old center A.J. Jenks has committed to play in the Ontario Hockey League. Jenks, who turns 16 later this month, was selected by Plymouth in the 7th round (132nd overall) in this spring's OHL Priority Selection.
A native of Wolverine Lake, MI, Jenks played last season for the Detroit Honeybaked Midgets, where he scored 26 goals with 29 assists for 55 points and 97 penalty minutes in 66 games. Prior to that, Jenks spent the bulk of his youth hockey days playing locally in the Compuware system.
The Whalers have a history of drafting players and signing local players from the Compuware Youth system, including James Wisniewski (Chicago Blackhawks), David Legwand (Nashville Predators), Nate Kiser, Jared Newman and Damian Surma, among others.
"We're excited about having A.J. here in Plymouth," said Whalers' Head Coach and General Manager Mike Vellucci. OHL Central Scouting had Jenks very highly rated leading up the 2006 OHL Priority Selection. Robert Kitamura, OHL Central Scouting Chief Scout says that "he has the potential to be a dominant force in the OHL as possesses great skill, size and is an extremely hard worker".


text:
If you tune in to Uzalo, then you are no stranger to the hunk that is Nay Maps. But who exactly is this dream guy and what is he all about? What does he do? Who is he dating? Find out his aspirations in life, his motivation, and dreams. Have you ever heard him sing? You definitely want to continue reading to satisfy your curiosity on this and much more. Take a peek into the creative world of Nay Maps.
Nay Maps is an actor based in South Africa, but there is a lot more than meets the eye when it comes to this Uzalo actor. He is very talented and aspires to take a step into the music industry very soon. But first, let us delve into his origins to get a vivid picture.
Early life and background
Nay Maps' real name is Nkosinathi Maphalala. Born on March 30th in Pretoria, Gauteng, South Africa. Nay Maps age is said to be 30 years old, but nobody really knows his exact date of birth, and maybe he prefers to keep it personal. He is the first born of three children. Nay Maps' Siblings are two younger sisters following swiftly behind him. He never hesitates to show affection for both of them.
READ ALSO: Dududzane Zuma siblings - What do we know about his brothers and sisters?
He attended Sunnyside Primary School and Lyttelton Manor High School. He then joined the University of Pretoria where he majored in Information technology, programming, and software. He really is the embodiment of beauty and brains.
Despite having an educational background in the sciences, Maps' heart longed for the creative arts and that is how he ended up with the decorative titles of "TV presenter", "Actor" and "Musician" all under his belt. His breakthrough moment on television was presenting on the lifestyle show, Hashtag, that aired on channel ANN7. Concurrently, he also worked in the modelling industry and made appearances on commercials.
In 2014, Maps landed a role in the second season of isiBaya, guest starring as Tshepo. From then on, it has only been one way up the ladder of success for Maphalala. He also featured as a celebrity contestant on season eight of Tropika Island of Treasure, a reality competition series airing on SABC 3.
Uzalo, the beginning and end
The premier of Uzalo, South Africa's juiciest drama series yet, saw Nay rise to stardom almost instantly when he was cast to play Mxolisi in Uzalo. In case you were wondering what is the real name of Mxolisi Uzalo? Well, there you have it. It is none other than the talented Nkosinathi Maphalala. Mxolisi seemed to have gathered a fan base for himself and it is no wonder numerous viewers and fans of the soap were outraged when the TV series's head writer, Bongo Ndaba, officially announced that Nay Maps, Nokuthula Manila and Glen Gabela would no longer be part of Mzansi's most viewed show as of November 2018, after the end of the fourth season.
READ ALSO: Trevor Noah height, age and ethnicity
Nay played the role of Mxolisi Mdletshe, a young man distancing himself away from the family business after witnessing the order of the day which included his father's shady dealings, violence and clashes with law enforcement.
Thobile, played by Nokuthula, is the sweet, fun and bubbly girl on the block but with a hint of slyness. She worked at the nail bar of Nkule's salon.
Gabela played the character of Mfundisi Mdletshe.
The Uzalo actors real names include (in no particular order);
- Dawn Thandeka King - Lindiwe 'MaNgcobo' Xulu-Mhlongo
- Gugu Gumede - Hlengiwe Mlambo-Mhlongo
- Nompilo Maphumulo - Nosipho Xulu
- Masoja Msiza - Nkunzebomvu Mhlongo
- Baby Cele Maloka - Gabisile Mdletshe-Zikhali
- Siyabonga Shibe - Qhabanga Khumalo
- Thembinkosi Thwala - Mondli Mdlalose
- Khaya Dladla GC - Gamakhulu Cetshwayo
- Thuthuka Mthembu - Nonkanyiso
- Wiseman Mncube - Sibonelo Zikhali
- Nkanyiso Makhanya - Njeza
- Noxolo Mathula - Lily Dongwe
- Nomcebo Gumede - Mumsy Mdletshe
- Khumbulani 'Kay' Sibiya - Ayanda Mdletshe
- Mpumelelo Bhulose - Gxabhashe Xulu
- Thokozani 'TkDee' Dlamini - Zweli 'Mastermind' Maphumulo
- Leleti Khumalo - Zandile 'MaNzuza' Mdletshe
- Glen Gabela - Melusi Mdletshe
- Nay Maps - Mxolisi Mdletshe
- Nokuthula Mabika - Thobile Fakazi
- Jo-Anne Reyneke - Sindiswa Main
- Sihle Ndaba -Smangele Maphumulo
READ ALSO: Cassper Nyovest house - inside pictures, location and price
Some of the questions asked about this soap-drama series only show how dedicated South Africans are to this. How old is Ntokozo Dlamini? Who is GC on Uzalo? Who is Masoja Msiza? No worries, we have got you covered with the details.
Uzalo premiered in 2015 and is currently running through its fifth season with over eight hundred episodes thus far. It has an IMDb rating of 6.2/10. Is it possible to binge watch? Most definitely!
Ntokozo Dlamini, who plays Mastermind Mphumulo on the TV series, was born on the 8th of January, 1991. That would make him 28 years of age currently. Apart from acting, he doubles as a businessman and a radio personality too.
In Uzalo, GC is played by Khaya Dladla. During an interview, Khaya revealed that GC is a rather embarrassing character and that he would definitely have a problem being such a person in real life. He went ahead to also say that he has absolutely nothing in common with the character he plays except for the fact that he is gay in real life and in the series as well.
Masoja Msiza is a poet, musician and actor who debuts in the second season of isiBaya as Bhodlimpi. He also has a recurring role in Umlilo, playing the character of Watermelon.
Fun facts about Nay Maps
Despite the sudden and disappointing set back for fans and viewers all over South Africa, the talented Nay still has a positive outlook on life and various opportunities for him and his career in acting. During an interview, he stated that his 5-year goal is to become an A-list Hollywood actor. We sincerely wish him all the best.
Apart from acting, the young talent also is a musician. He owes his musical bone to his father, who not only is a pastor but a musician too, and his mother whose undying love for music motivates him. He is diverse with his genres of music, showing interest in RnB, Soul, and Hip-hop. During his interview with Destiny Connect, he mentioned that he plans to take his music much more seriously this year, work on a few collaborations, and drop a couple of singles for all his fans out there. So far, there are no official records dropped by the actor, but it is safe to say we are all looking forward to those incoming Nay Maps songs, and we will be the first with the news when they do drop. However, if you are somewhat skeptical about this man's musical talent and vocal range, check out a few of the song covers he has done, from "Controller" by Drake to "Adorn" by Miguel. Could he be the next big thing in music?
READ ALSO: Top 10 things to do in Durban in 2019
As if having an amazing voice was not more than enough creative energy in one person, he went ahead and dropped his very own clothing line dubbed Nay Maps Clothing. It is currently located in Durban but he made it clear that he is currently working out a system to have his merchandise reach other provinces.
Currently, the creative genius is single and apparently in no hurry to find the right one, but willing to mingle. Sources reveal that Nay Maps girlfriend and himself broke up right before joining Uzalo after having a three-year relationship. In 2016, rumours had it that he was dating his co-start, Gugu Zulu. The lovely actress denied everything and called them nothing but rumours.
Nay Maps' Instagram handle is currently @naymaps, with 481K .followers thus far. His other social media handles are as follows; Twitter @maps_maphalala and Facebook, Nay-Maps.
It goes without saying that Mr. Nkosinathi "Nay Maps" Maphalala is one talented man whose limit is beyond the sky. We hope that he continues to outdo himself in every way possible. From a TV show presenter to acting on a series for four seasons, he started his own clothing company.
READ ALSO; Freedom Day South Africa 2019: History in pictures


text:
Mayor Continues Process Improvement with "Permitting Open House"June 28, 2012, 9:40 AM HST · Updated June 28, 10:15 AM 0 Comments
By Sonia Isotov
A "Permitting Open House" will be held on July 6 by Mayor Alan Arakawa's Permit Process Improvement Team (PPIT) taskforce and the public is encouraged to attend this free event.
Representatives from the County of Maui's Planning, Public Works, Environmental Management, Water and Fire Departments will be available to answer residential and business related permitting concerns right at the event, or set up a follow-up appointment to meet with the appropriate county departments.
Those interested should come up to the 9th floor of the Kalana O Maui building on July 6 between 1 p.m. and 4 p.m. Residents and business owners are encouraged to bring their building plans and other supporting documents.
Once registered at the event, attendees will be able to talk to speak directly to representatives from the departments of Planning, Public Works, Environmental Management, Water and Fire regarding permits. Directors and deputy directors for the departments will also be present.
For more information about the event, please call Capital Improvement Program Coordinator Wendy Taomoto at 270-6258.


text:
Now that we have covered the not so surprising benefits of cloud, it's time to dig into the good stuff. Interestingly enough, all five reasons are based on a simple truth: true multi-tenancy brings true benefits to all tenants.
What is true multitenancy? A true multitenant solution is one wherein there is sharing of compute, network, and storage between tenants. This is in contrast to a hosted offering. A hosted offering is just a premises solution that sits siloed in someone else's data center. There is no sharing in a hosted offering – each tenant has its own set of servers, its own set of databases, and often, its own IP network. A hosted offering provides total isolation between each tenant. On the surface, this may seem like a benefit! When there is isolation, problems with one tenant have no impact on any other tenant. However, it misses out on a key benefit of true cloud solutions:
Because true multitenant solutions share compute, network and storage resources across tenants, the costs of providing service are amortized across all tenants, and the benefits of those costs are shared by all tenants.
This core benefit manifests itself in five surprising ways:
On the surface this seems counter-intuitive. However, when built properly cloud solutions can have far better reliability. The reason for that, is that the cloud provider can invest in complex and expensive technologies for achieving high availability. The costs of that investment – in terms of development dollars, operational staff, and operational expenses, are amortized across all tenants. And, in a true cloud solution, those costs do not scale linearly with the number of tenants – they are fixed (such as development costs), or scale sub linearly (such as operational staffing). With on-premises solutions this is fundamentally not true.
What are these expensive technologies? One of them is georedundancy – providing solutions that have backup hardware and software in far flung locations. Another is active/active high availability, requiring multiple data centers in the same region, with both handling traffic, and with data replicated between them. These solutions require a lot of technologies – complex load balancing to route traffic to the right place; complex DNS solutions, such as any casting; complex databases with replication; high speed networks, and so on.
Another expensive technology is redundancy within a data center, eliminating all single points of failures (SPOF). This is not just an issue of hardware- the software must be purpose designed to operate in this fashion. This is complex stuff, which is also hard to operate – often requiring investments in automation software to manage it.
A cloud provider does this work once, and the benefits accrue to all tenants, large and small.
A great example of this is Google search – a SaaS based product that has achieved incredible levels of reliability, far beyond what any premises based solution has done.
Security, like reliability, is an issue of cost. Most of this cost is in software development and operational processes, both of which are either fixed or sublinear with tenants, so that the costs can be amortized over all customers.
One example of this are certifications – such as PCI or SOC. These certifications are achieved when there is a full suite of operational processes in place, and those processes are followed. It requires an investment in people, training, and tooling in order to achieve these. The certification itself is not important – what is important are the training, processes and tooling that are achieved. Such investments could also be made for on-premises software, but they often are not because of the high costs. In the cloud – once achieved – it works for all tenants.
Another example is the deployment of complex security software, such as firewalls, intrusion detection systems, security operation centers, hardened operating systems, and so on. These are all fixed costs which are often not done on premises, but which can be done by the cloud provider, and once done, the benefits accrue to all tenants.
Yet another example is denial of service mitigation. These are some of the hardest attacks to prevent, often requiring complex network setups (BGP peering) with third parties to offload and blackhole traffic, along with systems to detect and invoke mitigation of these attacks. Most companies do not make these investments on premises. But, a cloud provider can do it once, and the cost is amortized across all tenants, and all receive the benefit.
Are you on the edge of your seat yet? Tune in next week for our final installment of our Reason to Move to the Cloud Series to learn our last three benefits.
If you haven't had a chance to check out the rest of our series, you can do so here and here.
Jonathan Rosenberg is the Chief Technology Officer and head of AI at Five9. Jonathan has dedicated his career to transforming the telecommunications industry and joins Five9 from Cisco where he was CTO for the Collaboration Technology Group (CTG). Jonathan is also well known for his authorship of the SIP protocol, which is the foundation for modern IP-based telecommunications. Prior to Cisco, Rosenberg was the Chief Technology Strategist at Skype, where he guided the company's technology strategy. He received his bachelor's and master's degrees from MIT and holds a PhD in electrical engineering from Columbia University.
In 2002 he was named one of the most innovative young technologists in the world by Technology Review magazine. He also was named a "Top Supergeek" by CRN and won a Pulver Von Pioneer award for contributions to the VoIP industry. In 2015 he was presented with the Ohio University Strowger Award for transformational innovation in the telecommunications industry.
Call 1-800-553-8159 to learn more about Five9


text:
The compact Metro balances portability, convenience and performance. Wind tunnel tested up to 55 mph. Blunt tips that redirect, transfer and distribute the effort used in opening the umbrella throughout entire canopy surface. 37" canopy, 14" long when closed. 0.77 lb.
For complete details, read our
Shipping and Return policies.
Can't find what you're looking for or need extra assistance? One of our in-house
experts will be happy to help you.
Email an expert now
Call 1-800-BERINGS to speak to someone, or browse through our Frequently
Asked Questions
Join our 1940 Loyalty Club and enjoy priority notifications for special events and promotions, discounts and more!
Sign up now


text:
How to apply
Although often intellectually exciting, doctoral research can also be a very demanding process and a very different experience to studying on a taught programme.
We will only admit students whom we are very confident will be able to complete their doctoral research within the appropriate period of time (three to four years full-time; five to seven years part-time).
Entry requirements
- A good undergraduate degree (high 2:1 or 1st), and a Masters degree in a subject relevant to their proposed research (preferably at Distinction level).
- A clearly worked out research proposal, which identifies the context, questions and methods of their project in a way that demonstrates an understanding of key literature and debates in that field.
- Applicants must be certain that they will have sufficient time and financial support to be able to devote enough time to their research (on average 35 hours per week full-time, 18 hours per week part-time).
- For students wanting to undertake empirical research, it is advantageous to have previously undertaken relevant research methods training, although training in quantitative and qualitative methods can be provided in the College through the period of your research.
Identify a supervisor
- If you are thinking of applying to undertake doctoral research in our department, then look at the areas of research expertise for our staff to check that there is someone who might be interested in acting as a supervisor for your project.
Make a pre-application enquiry
- Once you have identified a supervisor, you may wish to email them directly to see if they would be interested in your project, or if you cannot see a particular staff member who might be appropriate for this then email the Director of Graduate Studies, Amber Jacobs (firstname.lastname@example.com) who will be able to advise you further.
- Even at the initial point of contact with our Department, it would be helpful if you have at least a 200-word summary of your proposed research project so that we can make an informed judgment about whether project is something that we could take on. Potential supervisors may also be happy to have an informal meeting with you to discuss your project before you submit a formal application.
- It is usually worth making informal contact with the Director of Graduate Studies (firstname.lastname@example.com) to check the suitability of your academic background or project before submitting a formal application form to the College.
Submit a formal application
- You make a formal application online by following the link at the bottom of the MPhil/PhD programme page.
- We ask applicants to submit a 2000 word research proposal with their application form setting out the academic context of the project, its core research questions and theoretical framework and its methodology.
- On receipt of the application form, suitable candidates will be invited for interview, after which we are usually able to let you know very quickly whether or not your application has been successful.