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Manuscripts Published
Title: Phytochemical and Biological Evaluation of Banana, Cantaloupe and Guava Waste Parts
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Author Affiliation: National Organization for Drug Control and Research, Giza, Egypt
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Background: This work aimed to study the lipoidal matter, phytoconstituents, total polyphenols (TP), total flavonoids (TF) and total carotenes (TC) contents of peels of both Musa paradisicae L. var. sapientum Kuntze (banana) and Cucumis melo L. (cantaloupe) in addition to pulp of Psidium guajava L. (guava) cultivated in Egypt and evaluate their antioxidant, antimicrobial and anticancer activities. Methods: Lipoidal matters were prepared and analyzed by GC/MS according to British pharmacopeia. TP, TF and TC of 80% hydro-methanolic extracts of the parts under investigation were detected by colorimetric methods. The isolated compounds were identified by different physico-chemical methods including UV, HPLC, 1H NMR and ESI-MS. Results: Palmitic acid was the main saturated fatty acid in the three parts and the percentage of sterols, in banana peel only was detected as 72.47% higher than the percentage of hydrocarbons (23.58%). Twenty compounds were isolated and identified by different physical and chromatographic techniques (7 compounds from banana peels, 5 compounds from cantaloupe peels and 8 compounds from guava pulp). Extract of banana peel showed the best antimicrobial activity while extract of guava pulp showed the best activity against all tested tumor cell lines. Conclusion: Thus, waste parts of the investigated fruits showed a significant medicinal value for their active compounds.
Cite this article as:Mona E. El-Tantawy, Eman G. Haggag, Amel M. Kamal, Rasha M. Lithy,Phytochemical and Biological Evaluation of Banana, Cantaloupe and Guava Waste Parts,Journal of Pharmacy Research 2016,10(5),308-318.
Title: Effect of Pullulan concentration in fast dissolving films formulation and exploration of film properties
Category: Pharmaceutical Biotechnology
Section: Research Article
Author Affiliation: Department of Biotechnology, K. L. University, Green Fields, Vaddeswaram- 522502, Guntur (Dist), A.P., India.
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Background: Dissolvable oral thin films made from biopolymers gain much attention by pharmaceutical industries due to their fast dissolution capabilities. Objective: To cast the pullulan based film with plasticizer and silver nitrate and to explore the film properties for appearance, thickness, and disintegration and dissolution times for various films. Materials and methods: Aqueous solutions of pullulan (1-5%), 1-5 % of poly ethylene glycol (400, 600 varieties) and 1- 10 mM silver nitrate were formulated into films by solvent casting method. Thickness was measured by screw gauge and disintegration and dissolution times were physically observed and reported. Results: Formulated films were clear transparent, translucent and opaque in color. Least values of disintegration (15 sec) and dissolution (37 sec) times were observed and increase in the concentration of polymer and plasticizers increased the disintegration and dissolution times. Conclusion: The prepared pullulan based films can be used as fast dissolving films for systemic delivery of active pharmaceutical ingredients (APIs).
Cite this article as: V S Rama Krishna Ganduri, N Meher Reethika, M Jayasai, V Sirisha, S Vasudha, Sudhakar Poda,Effect of Pullulan concentration in fast dissolving films formulation and exploration of film properties,Journal of Pharmacy Research 2016,10(5),211-215.
Title: Effect of Aspirin and Celecoxib on Lens Glutathione and Soluble Protein Profile in Naphthalene-Induced Cataract in Wistar Rats
Category: Pharmacology
Section: Research Article
Author Affiliation: Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062,India
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Background: Opacification of eye lens causing cataract, has become a leading cause of blindness worldwide. Aspirin, a non selective COX inhibitor and Celecoxib, a NSAID and selective COX II inhibitor, have been evaluated for their anti-cataract effect using naphthalene cataract model. Methods: Adult female albino rats of Wistar strain weighing between 180 and 230 grams were taken and divided into six groups. Group I received light liquid paraffin 5 ml/kg/day p.o. for 6 weeks. Group II received naphthalene solution 0.5 gm/kg/day p.o. for first three days and 1 gm/kg/day p.o. thereafter for six weeks. Group III received Aspirin suspension at the dose of 100 mg/kg/day p.o. along with naphthalene. Group IV received Celecoxib suspension at the dose of 34 mg/kg/day p.o. along with naphthalene. Group V received Aspirin suspension alone at the dose of 100 mg/kg/day p.o. Group VI received Celecoxib suspension alone at the dose of 34 mg/kg/day p.o. Drug suspensions were made every day by 1% carboxy methyl cellulose (CMC) in 25 mM sodium phosphate buffer, pH 7.4. All the above groups were treated for 42 days. Cataract was examined by torchlight and ophthalmoscope. Cataract was developed in all animals. On the 43rd day lenses were removed from the eyes of all groups of rat for estimation of lens glutathione and lens soluble protein. Results and discussion: Naphthalene administered to the rats reacted via a metabolite 1, 2-naphthequinone which caused oxidative damage primarily to the lens proteins located in the cortex and decreased the cellular oxidants level. The fact that decreases in reduced glutathione (GSH), the earliest biochemical changes observed, has suggested that oxidative stress may be the primary mechanism of damage in this model. With the increase in oxidative stress created by 1, 2- naphthoquinone, the protein gets denatured and forms disulfide cross-linkages leading to disulfide and mixed disulfide bond formation, hence protein aggregation, precipitation and lens opalescence. Our test drugs have increased the GSH and soluble proteins level thereby shown protection towards cataract. Conclusion: Lens glutathione and soluble protein profile showed the preventive role of Aspirin and Celecoxib in naphthalene-induced cataract in female rats.
Cite this article as: Syed Ehtaishamul Haque and Mohammad Tauseef,Effect of Aspirin and Celecoxib on Lens Glutathione and Soluble Protein Profile in Naphthalene-Induced Cataract in Wistar Rats,Journal of Pharmacy Research 2016,10(5),270-274.
Title: Amelioration of gastrotoxic effect of indomethacin by piperine in male Wistar rats: a novel therapeutic approach
Category: Pharmacology
Section: Research Article
Author Affiliation: Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92 APC Road, Kolkata 700 009, India
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Background: Gastric ulcer, an alarming disease among middle aged person in India and middle East Asia, generally develops due to long term use of Non-Steroidal Anti Inflammatory Drugs (NSAIDs), consumed as pain killers. It is well established that oxidative stress and free radical mediated injury play a pivotal role in generation of gastric ulcer. Antioxidant activity and gastro protective effects of black pepper are well known for long time. Piperine, a major alkaloid present in black pepper also possesses free radical scavenging activity. Objective: The aim of this study is to evaluate the ameliorative role of piperine against indomethacin, a classical NSAID, induced gastric damage. Methods: Indomethacin was orally administered in male albino Wistar rats to generate gastric ulcers. These rats were orally fed with graded doses of aqueous solution of piperine prior to indomethacin administration. Oxidative stress biomarkers, activities of antioxidant and pro-oxidant enzymes, PGE2 level, activities of mitochondrial enzymes and histology of gastric tissues were studied. Results: From the obtained data, it was seen that, Indomethacin treatment altered all the above mentioned parameters whereas, piperine pre-treated animals were protected against indomrthacin induced ulceration. Conclusion: Hence, piperine possess the potentiality to be used as an antiulcer drug against indomethacin induced gastric ulcer or can be used as an co-therapeutic agent among those patients undergoing NSAID treatment.
Cite this article as:Nirajan Ghosal, Syed Benazir Firdaus, Sudeshna Paul, Shamreen Naaz, Aindrila Chattopadhyay, Prachi Shukla, Garima Jain, Sanjib Pattari, Vinod D. Rangari and Debasish Bandyopadhyay,Amelioration of gastrotoxic effect of indomethacin by piperine in male Wistar rats: a novel therapeutic approach,Journal of Pharmacy Research 2016,10(5),240-254.
Title: Antimicrobial activity of some medicinal plant extracts and its synergistic interaction with some antibiotics
Category: Microbiology
Section: Research Article
Author Affiliation: Phytochemical, Pharmacological and Microbiological laboratory, Department of Biosciences, Saurashtra University, Rajkot, India, 360005.
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Background: The synergism is a new concept in developing agents for antimicrobial therapy. The new approach is combination therapy i. e. combination of different plant extracts with antibiotics against resistant microorganisms which may lead to new ways of treating infectious diseases. Synergistic interaction means when two agents are combined together and they exert an inhibitory effect that is greater than the sum of their individual effects. The present study focuses on the in vitro antimicrobial activity and synergistic activity of various parts of different plants such Aegle marmelos, Annona squamosa, Citrus limon, Piper betle, and Azadiracta indica. Material and Method: The synergistic antimicrobial activity was evaluated by the Agar disc diffusion method against Gram- positive, Gram -negative and Fungi. Result and Discussion: All the plant extracts with Gentamicin showed good synergistic antibacterial activity against Gram-positive and Gram-negative bacteria. All the plant extracts with Ketoconazol showed good synergistic antifungal activity against fungi. Conclusion: Hence, these plants extracts can be used as good medicinal sources in combination with antibiotics to treat infectious diseases.
Cite this article as:Hemali Padalia, Anjali Trivedi, Sumitra Chanda,Antimicrobial activity of some medicinal plant extracts and its synergistic interaction with some antibiotics, Journal of Pharmacy Research 2016,10(5),211-220.
Title: Storage and Disposal of Medicines in Home -A Review
Category: Clinical Pharmacy and Related Medical Science
Section: Review Article
Author Affiliation: Department of Pharmacology and Clinical Pharmacy, K.B. Institute of Pharmaceutical Education and Research, Gh-6, Sector -23, Gandhinagar, Gujarat,India
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Appropriate household storage and use of drug products reduce drug wastage and unnecessary hazards. Rational use of drug also focuses on the storage and disposal of drugs irrespective of both Over the Counter (OTC) and prescription drugs. At present, pharmacy practice is in developing stage and focuses on drug related issues. Therefore, the awareness and importance of storage and disposal of drugs among consumers remained/s underreported and less focused topic. Pharmacist has prime responsibility to make aware people regarding storage and disposal of medicine.
Cite this article as: Patel Denis Pankajkumar, Sneha Chacko, Bhatt Sandipkumar Prakashkumar,Storage and Disposal of Medicines in Home -A Review,Journal of Pharmacy Research 2016,10(5),290-295.
Title: Studies on Phytochemical Screening of Leaf Fraction of Lantana camara Linn.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Author Affiliation: Department of Biotechnology and Bioinformatics, College of Commerce, Arts and Science (Magadh University, Bodh Gaya), Patna
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Background: The study was conducted to determine the antimicrobial activity of varying concentrations of Lantana camara Linn. leaf extracts against Staphylococcus aureus, Bacillus subtilis and Escherichia coli. Methods: Broth microdilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was evaluated through streaking of bacterial suspension onto Mueller-Hinton agar. Phytochemical tests were done to identify bioactive compounds present in the extracts. Results and Discussion: The results showed that among extracts used, L.camara leaf ethanolic fraction (EF) demonstrate best antibacterial activity. The MIC of ethanolic fraction ranges from at 1,250μg/mL – 5,000μg/mL. Bacillus subtilis is the most sensitive organism inhibited at 312.5 ìg/mL. The MIC-MBC ratio revealed that the extracts possess bactericidal activity against test bacteria. Phytochemical evaluation indicates the presence of saponins, tannins and terpenoids in EF. Conclusion: L.camara leaf ethanolic fraction showed antibacterial activity and contain phytochemicals responsible for the broad antibacterial spectrum of the plant which may lead to new drug development.
Cite this article as: Preeti Caesar, Jainendra Kumar,Studies on Phytochemical Screening of Leaf Fraction of Lantana camara Linn.,Journal of Pharmacy Research 2016,10(5),304-307.
Title: Phytochemical Evaluation and Antiinflammatory Effects of Hymenodictyon excelsum (Roxb.) Wall Grown in Uttarakhand State of India
Category: Phytochemical Study and Pharmacological Activity
Section: Editorial
Author Affiliation: FRI (ICFRE), Dehradun
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Background: A number of medicinal plants have traditionally been used as potent anti-inflammatory drug. The present study was aimed at phytochemical evaluation and assessment of anti-inflammatory activity of bark of Hymenodictyon excelsum (Roxb.) Wall., a deciduous tree in the Himalayan region of India. Methods: Different extracts of the bark were qualitatively evaluated for presence and/or absence of different types of phytochemicals. Physicochemical evaluation and TLC profiling of extracts was carried out to develop standard parameters for authentication. The anti-inflammatory activity of the methanolic extract was carried out by egg albumin induced rat paw edema model. Results: The phytochemical evaluation showed the presence of highest number of secondary metabolites in the methanol extract. The tested plant exhibited significant anti-inflammatory activity comparable to the standard anti-inflammatory drug Piroxicam. Conclusion: The study led to the conclusion that the bark of H. excelsum possesses promising anti-inflammatory efficacy. Results of physicochemical and phytochemical studies provided the scientific basis to bioefficacy of the plant. However, further research is needed on the active ingredient of the plant responsible for anti-inflammatory and other biological activity.
Cite this article as :Paramita Chakraborty, Y. C. Tripathi, Devesh Tewari, Lokesh Upadhyay,Phytochemical Evaluation and Antiinflammatory Effects of Hymenodictyon excelsum (Roxb.) Wall Grown in Uttarakhand State of India.,Journal of Pharmacy Research 2016,10(5),199-204.
Title: Phytochemical and pharmacognostic evaluation of leaf and stem extracts of Gynochthodes ridsdalei Razafim & B. Bremer (Rubiaceae): An endemic medicinal plant of southern Western Ghats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Author Affiliation: Plant Tissue Culture and Molecular Biology Lab,Department of Botany, University of Kerala, Thiruvananthapuram,Kerala 695581, India
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Background: Phytochemistry describes the large number of secondary metabolic compounds found in plants. Pharmacognosy describes the discovery of new drugs or as an aid for plant physiology studies. Methods: The powdered leaves and stem of Gynochthodes ridsdalei ( Syn: Morinda reticulata) were used for physicochemical, fluorescent analysis and different solvent extracts of leaf and stem were used for phytochemical screening. Results and Discussion: The results of physicochemical parameters such as moisture content, fibre content, total ash, acid insoluble ash, water soluble ash, sulphated ash, alcohol soluble extractives and water extractive values were interpreted in the tables followed by the results of fluorescent analysis and phytochemical analysis. Conclusion: The present investigation on the pharmacognostic and phytochemical evaluation serve as a tool to identify and determine the quality and purity of the plant material in future and the phytochemicals present in the plant which is having many medicinal properties.
Cite this article as: Renji Ramachandran Nair, Gangaprasad Appukuttan Nair,Phytochemical and pharmacognostic evaluation of leaf and stem extracts of Gynochthodes ridsdalei Razafim & B. Bremer (Rubiaceae): An endemic medicinal plant of southern Western Ghats,Journal of Pharmacy Research 2016,10(5),233-239.
Title: Hybrid Triazoles: Design and Synthesis as Potential Dual Inhibitor of Growth and Efflux Inhibition in Methicillin Resistant Staphylococcus aureus.
Category: Pharmaceutical Chemistry
Section: Research Article
Author Affiliation: Department of chemistry, Vinayakrao Patil Mahavidyalaya, Vaijapur- 423701 Dist Aurangabad, Maharashtra, India
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Background: Staphylococcus aureus, the bacteria on the verge of eradication once, is now a great threat to mankind due to resistance. Emergence of methicillin-resistant Staphylococcus aureus (MRSA) & vancomycine-resistant Staphylococcus aureus (VRSA) have reaffirmed their dominance in the area of infections. However, new antibacterial drugs with new mechanisms of action have not been developed in over forty years. Apart from mutation, efflux of drug by bacteria is one of major way for drug resistance. Methods and Materials: Efflux inhibitors (EI) have been tested recently as adjuvant therapy to treat MRSA & VRSA. Toxicity and untoward side effects, limits wide use of these EI to treat MRSA & VRSA. Here we report a series of compounds containing linked triazoles to hybrid molecules derived from known efflux inhibitor. Synthesized molecules were evaluated as growth (GI) and Efflux inhibitor of TB initially with S. aureus. Pharmacologically active compounds were then tested for their cytotoxicity to further narrow down search. Results & Discussion: Most active compounds 107, 121, 132 & 134 were then tested for their GEI action against methicillin-resistant S. aureus. Said compounds were also tested for their synergistic action with first line and second line anti-TB drugs and ethidium bromide (EtBr). Conclusion: We herein report compound 135 as most potent dual inhibitor of MRSA.
Cite this article as : Prasad P. Dixit, Prashant P. Dixit, Bharat D. Dond, Shivajirao N. Thore,Hybrid Triazoles: Design and Synthesis as Potential Dual Inhibitor of Growth and Efflux Inhibition in Methicillin Resistant Staphylococcus aureus.Journal of Pharmacy Research 2016,10(5),275-289.
Title: Synthesis, characterization and anti-microbial activities of novel N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[3-chloro-2-(nitrophenyl)-4-oxo-azetidin-1-yl]benzenesulfonamides.
Category: Pharmaceutical Chemistry
Section: Research Article
Author Affiliation: Department of Pharmaceutical Chemistry, Yashwantrao Bhonsale College of Pharmacy, Sawantwadi – 416 510 (M.S.) India
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A series of novel N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[3-chloro-2-(3-nitrophenyl)-4-oxo-azetidin-1-yl]benzenesulfonamide 6-17 and N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[3-chloro-2-(4-nitrophenyl)-4-oxo-azetidin-1yl] benzenesulfonamide 18-29 derivatives were synthesized using appropriate synthetic route. Their structures were characterized by elemental analysis, UV, IR and 1HNMR. The entire test compounds 6-29 were screened for anti-microbial activity which exhibited good to moderate activity.
Cite this article as:Vijay Jagtap, Rashmi Mahabal, Vinod Mule, Sandip Murtale and E. Jayachandran,Synthesis, characterization and anti-microbial activities of novel N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[3-chloro-2-(nitrophenyl)-4-oxo-azetidin-1-yl]benzenesulfonamides,Journal of Pharmacy Research 2016,10(5),191-198.
Title: Studies on the Anti-fibrotic potential of Phyllanthus maderaspatensis Linn. hexane extract on human activated hepatic stellate cell line- LX-2
Category: Pharmaceutical Biotechnology
Section: Research Article
Author Affiliation: Plant Based Bioactives and Disease Biology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.
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Background: Hepatic fibrosis has become a serious life threatening condition, without effective therapy till date. This condition is characterized by increased deposition of Extra Cellular Matrix proteins (collagens, proteoglycans, fibronectin etc.), secreted by activated Hepatic Stellate Cells (HSCs) and hepatic scarring. Methods: In the present study, we used activated LX-2 cells that mimic HSCs functionally. To evaluate the in vitro anti fibrotic activity of the promising extract , the various methodologies adopted in this study are immunofluorescence, MTT , Morphological studies, and Hoechst staining. Results and Discussion: Our findings showed that Phyllanthus maderaspatensis Linn. hexane extract not only inhibits the proliferation of activated LX-2 cell (IC50– 200µg/ml for 48 hours or 100 µg/ml 72 hours), but also suppressed the fibrotic gene expression (as evidenced by the inhibition of α-Smooth muscle actin- the marker- expression) along with functional restoration. Our study showed that Phyllanthus maderaspatensis Linn. hexane extract has good anti-fibrotic potential. Conclusion: Through the preliminary in vitro screening studies, the anti-fibrotic potential of Phyllanthus maderaspatensis Linn. hexane extract has been demonstrated confirmedly, but demands further studies towards identification of the mechanism of action of the extract, which is underway.
Cite this article as: K.A. Krishnakumar, Sheena Philip, Greeshma Tom , V.V.Asha, Studies on the Anti-fibrotic potential of Phyllanthus maderaspatensis Linn. hexane extract on human activated hepatic stellate cell line- LX-2, Journal of Pharmacy Research 2016,10(5),205-210.
Title: In-vitro Antibacterial Activity in Different Extracts of Lantana camara L. Leaf Fraction
Category: Microbiology
Section: Research Article
Author Affiliation: Department of Biotechnology and Bioinformatics, College of Commerce, Arts and Science (Magadh University, Bodh Gaya), Patna
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Background: Medicinal use of plants is the oldest form of healthcare known to mankind. India has a rich profusion of medicinal plants and 75% of its folk population is still using herbal preparations. Present study reports about antimicrobial potentiality of Lantana camara as its leaf extracts exhibit good antimicrobial, fungicidal, insecticidal and nematicidal properties and the plant might be a novel source of antimicrobial drug. Methods: Two enteropathogens as (A) - B. subtilis (positive, obligate aerobic) and (B) - E. coli (Gram-negative, facultative anaerobic) were used for the present study. Four solvent phases viz, methanol, ethanol, acetone and aqueous were used for extraction of antimicrobial agent. The screening of antimicrobial property was done by well diffusion method. Results and Discussion: Leaves of Lantana camara showed excellent antibacterial activity in all the solvent phases used against both E. coli as well as B. subtilis. Lantana is effective against both the bacteria. The aqueous extract showed minimum ineffective antimicrobial activity against E. coli and B. subtilis, where as acetone phase showed maximum activity against B. subtilis and ethanol against E. coli as shown in the terms of maximum zone of inhibition. Conclusion: The leaves of Lantana camara linn. proved to be good antibacterial agent as they show antagonistic effect on the growth of both tested microbes in all the solvent phases used. Large scale production of its active constituents would be an advantageous for natural, herbal antimicrobial agents.
Cite this article as: Preeti Caesar and Dr. Jainendra Kumar,In-vitro Antibacterial Activity in Different Extracts of Lantana camara L. Leaf Fraction,Journal of Pharmacy Research 2016,10(5),301-303.
Title: Assessment of Variation in Rhoifolin Content in Aerial Parts of Uraria picta Desv. from Different Locations of Madhya Pradesh
Category: Natural Drugs
Section: Research Article
Author Affiliation: Natural Product Laboratory, Department of Chemistry, Govt. Model Science College, Pachpedi, Jabalpur (M.P.) – 482001, India
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Background: Uraria picta Desv. is one of the ingredient of ten herbs formulation called Dashmoola. Rhoifolin is an active compound which has been isolated from the aerial parts of Uraria picta and has been established as marker compound for quality evaluation of this species. In the present time of global resurgence in traditional and alternative health care systems, the quality assurance of medicinal plants is very essential. Since, WHO and herbal Pharmacopoeia are also emphasizing on quality standardization of medicinal plants in terms of active ingredients, the present study was aimed to assess the variation in rhoifolin content in aerial parts of Uraria picta collected from eight locations of Madhya Pradesh for its quality standardization and selection of superior chemotype. Methods: The powdered samples of aerial parts were extracted by soxhlet extraction in methanol for 4 hours on water bath. Extracts were quantified for rhoifolin content using Ethyl acetate: Formic acid: Glacial acetic acid: Water (10: 1.1: 1.1: 2.6) mobile phase and a CAMAG HPTLC system equipped with Linomat V applicator, TLC scanner, WIN CATS software Version 1.4.8 and Hamilton Syringe (100 µL). Results: Rhoifolin content varied from 0.039% to 0.195% among the aerial part samples of eight locations corresponding to seven agroclimatic regions of the state. The highest content was found in aerial parts of Pandado, Sehore (0.25%) followed by Kapoornala, Chhindwara (0.167%) and Pamakhedi, Khandwa (0.152%) respectively and lowest content in plant sample of Navali, Mandsaur (0.039%). Conclusions: The study provided significant variation in rhoifolin content in aerial parts of Uraria picta. The accession collected from Pandado, Sehore emerged out of best quality on the basis of rhoifolin content and superior chemotype too.
Cite this article as:Hari Om Saxena, Brij Mohan and Arun Kakkar,Assessment of Variation in Rhoifolin Content in Aerial Parts of Uraria picta Desv. from Different Locations of Madhya Pradesh,Journal of Pharmacy Research 2016,10(5),185-190.
Title: To study toxic potential of Melia azedarach, Euphorbia helioscopia and Sapium sabiferum leaves extracts against Cimex lectularius
Category: Pharmaceutical Chemistry
Section: Research Article
Author Affiliation: Department of Zoology, Kohat University of Science and Technology-26000, KPK, Pakistan.
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Objectives: The aim of the research work was to find out the toxic potential of Melia azedarach, Euphorbia helioscopia and Sapium sabiferum. C. lectularius or bed bugsare the ectoparasites of bats, man, chicken and rarely other animals, which are cosmopolitan in distribution. They reduce the caliber of human life by triggering banishment, discomfort, nervousness and restlessness.Bed bugs show resistance to Insecticides such as DDT, lindane, malathion, carbaryl, permethrin and d-phenothrin. Newly, researchers take countlessconcern in the use of plant extracts as a new control substitute to synthetic insecticides. Methods : In present study, toxicprospective of three local plants, Melia azedarach, Euphorbia helioscopia, and Sapium sebiferum against Cimex lectularius was determined. Plant samples were collected from territory of Abdul Wali Khan University, Mardan. For determination of toxic activity of these plants, 20 bed bugs were placed in each petri dish having filter paper saturated in different concentrations (100ppm, 200ppm, 300ppm) of water and chloroform extracts of leaves. In many choice experiment percent mortality of bed bugs was calculated after 12, 24 and 48 hrs. Results: Maximum mortality rate of Melia azedarach, E. helioscopia,and S. sebiferum was observed after 48 hours for all three plants in water solvent (10.34, 12.34and 14.34 %, 5.67, 7.67and 10.34%, 5.67, 8.00and 10.34 % correspondingly) as well as in chloroform solvent (9.67, 12.67 and 15.67 %, 8.67, 10.34 and 14.67 %, 8.34, 9.34 and 11.67 % respectively). Conclusion: Among three solvent extracts tested, the maximum activity was observed in both water and chloroform extracts of Melia azedarach against Cimex lectularius.
Cite this article as: Sumbal Haleem, Sadaf Niaz, Shahid Niaz Khan, Hameed Ur Rehman, Shazab Sajad, Naveeda Akhtar Qureshi,To study toxic potential of Melia azedarach, Euphorbia helioscopia and Sapium sabiferum leaves extracts against Cimex lectularius,Journal of Pharmacy Research 2016,10(5),226-232.
Title: Design and Synthesis of Hybrid Triazoles as Potential Dual Inhibitor of Growth and Efflux in Methicillin-Resistant Staphylococcus aureus
Category: Pharmaceutical Chemistry
Section: Research Article
Author Affiliation: Department of chemistry, Vinayakrao Patil Mahavidyalaya, Vaijapur- 423701 Dist Aurangabad, Maharashtra, India,
View Article
Background: Efflux inhibition is proven bacterial machinery responsible for removal of bacterial wastage including antibiotics. Recently, efflux inhibitors (EI) have been tested with encouraging results as an adjuvant therapy for treatment of various bacterial invasions especially methicilline-resistant Staphylococcus aureus (MRSA). Although, EI have emerged as innovative approach of treatment for several multi drug resistant bacterial infections including tuberculosis, toxicity profile limits their wider use. Materials and Methods: To address this issue, we have attempted synthesizing hybrid molecules those results by combining known EI and triazole. This synthesis was aimed to arrive at structure that possesses pharmacophore from known EI. Synthesized molecules were evaluated as growth inhibitors (GI) and Efflux inhibitor of S. aureus. Pharmacologically active compounds were then tested for their cytotoxicity to further narrow down search. Results and Discussion: Most active compounds 144, 145, 154 and 163 were then tested for their GEI action against MRSA. Synthesized compounds were also tested for their synergistic action with first line and second line antibacterial drugs and ethidium bromide (EtBr). Conclusion: We arrived at compound 145 as most potent dual inhibitor.
Cite this article as : Prasad P. Dixit, Prashant P. Dixit, Amol B Kale, Shivajirao N. Thore,Design and Synthesis of Hybrid Triazoles as Potential Dual Inhibitor of Growth and Efflux in Methicillin-Resistant Staphylococcus aureus,Journal of Pharmacy Research 2016,10(5),255-269.
Title: Detection of adulterated Radix valerian herb by FTIR spectroscopy and extraction solvent optimization for HPTLC fingerprinting
Category: Pharmacognosy and Herbal Drugs related study
Section: Editorial
Author Affiliation: K L University
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Background: Radix valerian is a natural preparation of the root and rhizome of the perennial herb utilized primarily in the treatment of insomnia and sleep disturbances. Quality control of valerian represents a major concern in the pharmaceutical industry due to the huge variety of these species and their almost daily new scientific findings. Objective: Our objective was to investigate the sensitivity of FTIR spectroscopy for the detection of adulterated Radix valerian and optimization of a solvent extraction method for HPTLC fingerprinting. Methods: Radix valerian medicinal plant adulterant was measured by FTIR spectroscopy. The obtained data were evaluated using SIMCA (soft independent modeling of class analogies) in order to determine the detection limits of adulterants with a dataset comprising 50 batches and HPTLC system was utilized to evaluate optimal solvent composition consisting of methanol, water and dichloromethane for which the flavonoid fingerprint is determined. Results: With regard to the chemometric analysis of the FTIR spectra we found that for this particular dataset the overall detection rates computed from leave-one-out cross-validation were 56.2%, 85.9% and 98.3% at 5%, 10% and 20% contamination levels, respectively. Solvent extraction optimization, we found that a mixture of 40-80% Methanol, 30-50% Dichloromethane and 10-30% water was most efficient for the analysis of the flavonoid patterns in the six plant systems under investigation. Conclusion: Concerning the extraction optimization, a universal solvent could not be defined exactly by response surface methodologies as reported in similar studies involving different analytical platforms mostly by HPLC but suggestions for near optimal solvent compositions with competitive performances compared to pure and 70% methanol could be made.
Cite this article as: Praveen Kumar Vemuri, Bhavana Talluri, VBSC Thunuguntla, Suryanarayana Veeravalli, Vijaya Lakshmi Bodiga,Detection of adulterated Radix valerian herb by FTIR spectroscopy and extraction solvent optimization for HPTLC fingerprinting, Journal of Pharmacy Research 2016,10(5),181-184.
Title: Formulation development and evaluation of Carbamazepine fast dissolving tablets
Category: Pharmaceutics
Section: Research Article
Author Affiliation: Department of Pharmaceutics, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopet, Guntur (Dt), Andhra Pradesh-522601, India.
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Background: The main objective of present research work is to formulate the Carbamazepine Fast Dissoving tablets. Carbamazepine, an antiepileptic, belongs to BCS Class-II and used to control some types of seizures in the treatment of epilepsy and Neuropathic Pain by blocking use-dependent sodium channels. Methods: The Fast Dissoving tablets of Carbamazepine were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in different combinations as a Sperdisintegrants by Direct Compression technique using 32 factorial design. The concentration of Crospovidone and Croscarmellose sodium was selected as independent variables, X1 and X2 respectively whereas, wetting time, Disintegration time, t50% ,t90%were selected as dependent variables. Results and Discussion: Totally nine formulations were designed and are evaluated for hardness, friability, thickness, Assay, Wetting time, Disintegration time, In-vitro drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for Wetting time, Disintegration time, t50%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations (C1, C2). According to SUPAC guidelines the formulation (F5) containing combination of 9.375% Crospovidone and 9.375% Croscarmellose, is the most similar formulation (similarity factor f2=82.675, dissimilarity factor f1= 2.049 & No significant difference, t= 0.041) to marketed product (TEGRETOL-100). Conclusion: The selected formulation (F5) follows First order, Higuchi's kinetics, mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.665).
Cite this article as: Raghavendra Kumar Gunda, J. N. Suresh Kumar, V. Satyanarayana, Swathi Batta, Ch . Meher Harika,Formulation development and evaluation of Carbamazepine fast dissolving tablets,Journal of Pharmacy Research 2016,10(5),216-225.
Title: Sequential Heating and Solvent Precipitation For Effective Pullulan Recovery From Jaggery Based Fermentation Broths
Category: Pharmaceutical Biotechnology
Section: Research Article
Author Affiliation: Department of Biotechnology, K. L. University, Green Fields, Vaddeswaram- 522502, Guntur (Dist), A.P., India.
View Article
Background: Cost-effective downstream processing is very important aspect in successful fermentative production of pullulan biopolymer. Objective: To study the heat treatment method for removal of proteins in cell free supernatant and to optimize the pullulan concentration using several solvents in terms of type, solvent ratio and precipitation time for their efficacy. Materials and methods: Fermentation broths obtained from sucrose and jaggery based shake flasks fermentations were exposed to heat at 50 to 1100C for 5 to 60 min to remove proteins and precipitated with organic solvents like ethanol, methanol, acetone, isopropanol, chloroform and diethyl ether. Various effects such as supernatant: solvent ratio, precipitation time were analyzed. Results: For jaggery (50 g/L) fermentation broth, the optimum heating temperature and time were found at 1100C and 50-60 min, respectively. Addition of Isopropanol, solvent ratio of 1:3 and 12 hours of precipitation time at 40C were observed for maximum pullulan concentration from precipitation. Conclusion: These sequential steps may enhance efficiency of pullulan recovery and would become effective downstream processing method.
Cite this article as:V S Rama Krishna Ganduri, Srinivasulu K, Usha Kiranmayi M, Bodaiah B, Y V V Aswani Kumar, Vijaya Lakshmi M, Sudhakar Poda, Sequential Heating and Solvent Precipitation For Effective Pullulan Recovery From Jaggery Based Fermentation Broths,Journal of Pharmacy Research 2016,10(5),296-300.


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Bloomberg TV
2 Feb 2018
The biggest problem in the UK is not Brexit
Nigel Wilson, Group Chief Executive at Legal & General, discusses the future of asset management with Tom Keene and Francine Lacqua on "Bloomberg Surveillance."
On Bloomberg TV, Nigel Wilson explains to Tom Keene and Francine Lacqua why investment within infrastructure is key to the future of asset management.
Watch the full interview below.

subset: commoncrawl


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Key Features
- 300 000m2 Developable Bulk
- Mixed use Development
- Highly accessible
- Close proximity to Gautrain, taxis and busses as well as highway on/offramps
- Pedestrian friendly environment
- Within walking distance of Rosebank retail, hotels medical facilities and schools
- This high quality lifestyle precinct is being developed as a Green Star precinct, one of the first of its kind in South Africa. Green precincts create healthy enviroments with reduced ecological footprints and well designed and connected public spaces.Phase 1 of Oxford parks is currently under construction, it will comprise three office blocks and a hotel with convenience retail and restaurants on the ground floor. All the buildings in this phase will be linked by a landscaped public piazza.Commercial office space will be built to a P Grade standard to reach a minimum of a 4 Star Green Star rating. The precinct will be managed privately by the owners association.


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If you'd like to join COGS we have a full (1 or 2 adults with children) and concession (pension card, health care card and full-time students) membership available. Please see below for pricing and our membership form.
Full membership includes 1 or 2 adults and their children who are under 18 years of age. The membership entitles the people on the membership to such benefits as may be decided upon by the COGS committee from time to time and include:
Concession membership is available for pension card holders, health care card holders and full-time students. Where the membership includes two adults, both adults must be eligible for the concession and evidence must be provided for both. To apply for concessional membership, please send the membership secretary a photocopy of the relevant cards or documents.
Memberships are for one year and start in August. Current members renew their membership each August for the one year and pay the annual fee. The table below shows the the annual fee amounts.
|Annual Fee
In addition to membership fees, members who take a plot in a COGS garden pay plot fees to cover water usage and other garden expenses. The fee for 2019/2020 is $3.45 per square metre per year. The COGS Committee review the fee each year.
If you wish to join COGS please download and complete a COGS Membership Form and return the completed, signed application by:
Email to (scanned as an attachment) firstname.lastname@example.com
Mail to
Membership Secretary COGS
P.O. Box 347
Dickson ACT 2602
Direct debit to cover the appropriate membership fees is the preferred payment method. A payment receipt must be attached to your completed, signed application. Cheques and Money Orders are also accepted.
Your membership card ID number will be emailed to you, with member login details to access the Member's Pages of the COGS website, which has a link to the Canberra Organic magazine. If you have an urgent enquiry, please email firstname.lastname@example.com for assistance.
Privacy: COGS collects and uses your personal information for membership and plot allocation administration, magazine delivery, and to provide you with information. We will not disclose your data to external parties without your consent.


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Inventions in 30 Seconds: 30 ingenious ideas for innovative kids explained in half a minute
These inventions changed the world - learn all about them in just 30 seconds!
From the first flushing toilet to futuristic robots, Inventions in 30 Seconds explains how key inventions revolutionized the world. Delivered in an energetic, informative style, children will gain a better understanding of how everyday life has been shaped by great inventions. The 30 Seconds series takes readers on a journey of discovery through a wide range of fascinating subjects. Each topic is presented as a quick 30-second soundbite, supported by flash summaries and full-color artwork. Fun, interactive missions with things to make or do support the topics, encouraging readers to test, explore, and discover even more.
Publication Date:
December 1, 2016


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For your consideration is this vintage 1960s Murray Super Deluxe fire truck pedal car. Beautiful original pedal car with genuine ladder and decals. Approximate dimensions are 43 inches long by 15.5 inches wide by 20 inches tall including rear railings. Very clean and solid pedal car. Shows light age wear to paint.
Some light scratching and some small dings but no large dents or bumps. It is a pity that the siren is missing.
Please, check photos and contact with any questions you might have. Item will be carefully packed to make sure it does not get damaged during transit. Please, examine the photos carefully.
They attest for the condition of the item much better than any words can. What you see in the photos is what you will be getting.
We are a family owned business located in Northeastern Pennsylvania. We have been dedicated to collecting, preserving, and providing antiques to other collectors and antique enthusiasts for many years. We specialized in antique toys, ephemera, advertising, and primitives; but we bring into our store all kind of antiques and oddities.
The item "VINTAGE 1960'S MURRAY SUPER DELUXE FIRE TRUCK PEDAL CAR HOOK LADDER FIRE CHIEF" is in sale since Thursday, July 14, 2016. This item is in the category "Toys & Hobbies\Outdoor Toys & Structures\Pedal Cars\Pre-1970". The seller is "theantiquetwist" and is located in Thompson, Pennsylvania. This item can be shipped worldwide.


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Domestic/overseas travel allowance expenses
Did you know that an employee travelling for work and is away from home overnight, will not be required to provide written evidence in respect of a claim for travel expenses where all the conditions are satisfied?
However, if you make a claim for accommodation expenses in respect of overseas travel, you must obtain written evidence, and maintain a travel diary (for trips of six or more continuous nights in a row).
For more information, contact Matt Zhou on 02 9957 4033.
Want more tax tips? Follow us @batescosgraveCA


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Dreaming of a Pink Christmas - South AdelaIde - Has Ended
DO Details
SA Brass Knockers – South Australia's first all-female brass band – will be adding a touch of pink to Christmas with a concert at the Grainger Studio on 7th December. in support of the McGrath Foundation's mission to raise money to fund McGrath Breast Care Nurses in communities right across Australia and to increase breast awareness in young women.
Featuring guest artist Jennifer Trijo the concert will be an entertaining afternoon of popular and Christmas music suitable for the whole family.
An initiative of the Kensington & Norwood Brass Band, the concert was inspired by Vivienne Little, K&N Brass Committee member, concert compere and wife of one of K&N's players, and her commitment to getting the word out regarding breast awareness following her own breast cancer diagnosis at just 46 years of age.


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- All contents © Jack Boardman
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Tag Archives: Pioneer Deadwood
"What are we doing here?"
Previously: "Greetings Captain Lincoln," Chris Earp wickedly smiled, "How do you feel about your next assignment being Fort Leavenworth's prison?" "You haven't that much influence," Lincoln weakly replied—he knew he was finished. "You know better," Wyatt rejoined, "You'll not see … Continue reading
"Greetings Captain Lincoln…"
Previously: Captain Boomer & Company were riding not far away from where Red Eagle destroyed the small wagon train. "Everything looks normal here." "It does, Boomer," Mac replied, "I think we need to check the lower road."
"They're still warm—let's ride!"
Previously: After which—Marshal Taylor administered the oath of office, concluding with, "Now—we have our work cut-out for us." "How so?" Chris asked. "We have word that a number of Sioux operating on the Wyoming side of the Black Hills—and their … Continue reading
They were now hunting for more victims.
Previously: Boomer & Joey delivered their prisoners to "Willie" Taylor, "They're all yours, Marshal." "Thank you, I think," Taylor replied, "Who are you fellows?" "We're bounty-hunters," Boomer replied, "We saw a poster claiming these fellows were wanted."
"I know a renegade Sioux who might be interested."
Previously: City Marshal William "Willie" Taylor heard someone enter his office as he was doing the necessary paperwork, "Hello, I'm Tyrone Marshal Mathers, and am wondering if you'd hire me as a deputy." "Have you any experience?" Taylor asked (without … Continue reading
"You fellas ain't a-gonna survive this."
Previously: Wyatt and Chris Earp returned to Nuttal & Mann's Saloon, along with Debra, Linda, and Ralph. "Where are Janet Smith, and Willie Jones?" Chris Earp asked.
Previously: Captain Boomer and Company patrolled for many, many miles along the RR line—and found no bad guys. "Well—this is fun!" "You think, Joey," Mac replied, "What you call fun—would be getting ambushed?"
Previously: "Gee," Mac grinned, "I wonder what my old friend General Whitcomb thinks about that?" "You know General McKinley, Sergeant Major?" "He was Colonel McKinley when we served together during the war."
"Pleased to meet you, Captain Lincoln—How may I help you?"
Previously: Captain Boomer and Captain Lincoln arrived at Fort Dakota. "Friendly Natives, Captain?" "They are quite friendly—and a necessary ally," Boomer replied, "There simply not enough regular troopers to patrol the Black Hills."
Chris has a plan…
Previously: "Welcome gentlemen!" Janet Smith exclaimed, "We've been looking forward to your arrival." Travis Johnson, Willie McGraw, Hal Barber, Eric Wilson, and Fred Thompson—all tipped their respective hats—Johnson was the first to speak, "Thank you, Ma'am, we're looking forward to … Continue reading


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ACT Capital Advisors is pleased to offer a leading Northwest specialty foods manufacturer company for acquisition. The Company's core business the manufacturing, distribution, and branding of "better for you" specialty foods. Prospective investors will find the following key investment considerations of highest interest.
For more information, please email or call Trevor Hill, ACT Associate
Email: email@example.com


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Some pretty amazing young girls at the St. Joseph Island Public School are planning a fundraiser and donating all of the proceeds to the Sick Kids Hospital that recently helped out their classmate Chase Glawson.
Chase, a grade 4 student from Richards Landing, has had a heart condition from birth, but was recently taken by medevac to Sick Kids Hospital after experiencing chest pains. Chase says, "I flew to the hospital in an airplane. Then they put about 20 stickers all over me and then got me to ride a bike and stuff."
Hillary Glawson says, "Chase is home now, back at school, and being closely monitored by his Cardiologist."
Grade 4 teacher Alecia Campbell explained to her class why Chase was absent and where he was. Her daughter Olivia, who is in the same class, said to her mom one night, "I want to do something for Sick Kids because they helped Chase. Olivia was thinking of a lemonade stand, but it's evolved into more since then.
Olivia and classmate Sydney Schmidt are making candy bags, selling water, freezies and lemonade. Olivia invited her older sister Julia to join in the sale.
Julia and fellow Grade 6 student, Charlotte Morrison have been super busy making items for a craft table. They have painted bird houses, bracelets, pot holders, and other handmade crafts ready for the fundraiser.
The girls want to invite everyone to come to their Sick Kids Fundraiser Sale on Saturday June 22nd from 11am-1pm in downtown Richards Landing in front of the Island Market.
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Wonder's Victory(1991)
(The fourth book in the Thoroughbred series)
A novel by Joanna Campbell
Ashleigh's determined to make her dreams come true...
In her second year of racing, Wonder, the Thoroughbred filly Ashleigh Griffen has helped raise, is the star of Townsend Acres Stables -- until the worst happens.
Just as Wonder is about to start training for the important Breeder's Cup race, Ally, Wonder's regular jockey, is injured and can't ride. Wonder doesn't like any other jockey, and she won't perform.
Only one person can ride Wonder now, and that's Ashleigh. She's never ridden in a race, but she's Townsend Acres' only hope. Can Ashleigh's dreams and Wonder's trust carry these two unlikely contestants into the winner's circle?
Read Thoroughbred and experience the love and friendship between a determined girl and a very special filly.
Genre: Young Adult Fiction
Similar books by other authors
Used availability for Joanna Campbell's Wonder's Victory
Hardback Editions
November 1991 : USA Library Binding
February 1993 : USA Library Binding
Paperback Editions
July 2002 : USA Paperback
November 1993 : USA Mass Market Paperback
April 1993 : UK Paperback
January 1993 : USA Paperback
October 1991 : USA Paperback
December 1915 : UK Paperback


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Having a hard time right clicking (not dragging) on andriod, could anyone walk me through the exact mechanics as I cannot seem to do it. Is it a single tap holding at the end, for how long? etc. ty kindly.
Did I post this in the wrong spot to get an answer?


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Finally I could get my hands a little bit dirty with Hydra when my beloved spouse entrusted me her MacBook for a few hours. All my other machines don't support OpenGL 2.0 yet and thus I could just sit and watch Joa having all the fun.
What can I say after my first attempts? I definitely love it. The calculation speed is awesome. The language is really simple, especially if you have done bitmap manipulation with other tools or languages before. There are some nifty object types and overloaded operators which I wish that they would exist in Actionscript. Multiplying a point with a matrix with just a "*"? Perfect!
Of course the limitations for the usage within Flash are a real bummer at first. No loops? No arrays? No nested operations inside of conditionals? Well, on the other hand limitations like these can be a real creativity booster, too. And I already see some ways how to work around those.
So here are my first three Hydra filters which will be Flash enabled (that means no forbidden operations inside). I wish I could see them animated already.
|Radial Gradient
|Circular Gradient
|Spiral Gradient


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COMMENTARY || No end in sight for conflict in Ukraine
Strife over Ukraine's Donbas region remains the single most intractable political problem in contemporary Europe, says U of A historian.
By DAVID R. MARPLES
It's been four and a half years since tensions between Ukraine and Russia erupted. Despite an uneasy truce negotiated two years later that remains in place, there is no sign the underlying causes of the conflict will be resolved any time soon.
In November 2013, Ukrainians poured into the streets of Kyiv to demand closer ties with the European Union. By the following spring, Ukrainian president Viktor Yanukovych, who ultimately opted not to sign the EU Association Agreement, fled. He resurfaced in Russia, declaring that he had been deposed in a coup by right-wing insurgents.
Russian president Vladimir Putin was in Sochi at the time, attending the Winter Olympic Games. Returning to Moscow, he authorized an invasion of Crimea from Russian naval bases and the mainland, initially led by troops without insignia dubbed by locals, "the little green men." The occupation took place without major casualties. There followed a dubious referendum, conducted under close military control, to incorporate Crimea into the Russian Federation. Russia ratified the annexation on March 21, 2014.
Shortly thereafter, armed pro-Russian groups took over government buildings in a number of eastern cities, sometimes assisted by locals, but led by outsiders who had been involved in Crimea. Putin and others spoke of the establishment of Novorossiya (New Russia), a reference to the new territories annexed by Catherine the Great in the 18th century.
The armed conflict that followed, however, was largely restricted to two Russian-speaking regions of Eastern Ukraine, Donetsk and Luhansk.
All other cities of Eastern Ukraine soon ejected the militants and restored their governments. The militants set up base in the city of Sloviansk under the leadership of a maverick Russian intelligence officer, Igor Girkin. During his leadership a Malaysian airliner, carrying 298 (mainly Dutch) passengers was hit by a missile fired from the rebel zone on July 17.
Ukraine responded with an "anti-terrorist operation" (ATO) zone. Ukrainian troops advanced on Sloviansk at the start of July after two earlier failed attempts to recapture the city. Girkin and his forces retreated to Donetsk. Girkin was dismissed as "defence minister" on August 14, 2014, but Donetsk remained the militants' new headquarters.
Russia then took a more direct role, supplying the anti-Ukrainian forces with advanced military technology, material supplies and "volunteer" troops. Ukrainian forces entered Ilovaisk on August 18 but were promptly encircled by militants and a massive contingent of Russian forces that had crossed the border starting August 24. After a five-day siege, Putin assented to a peaceful retreat by the Ukrainian army, but the Russians fired freely upon the government forces, killing about 1,000 and taking prisoner a further 500.
That disaster ended the ATO. Ukraine took part in armistice talks, hosted by Belarusian president Alexander Lukashenko and mediated by France and Germany, which led to "Minsk Protocols." The initial agreement in September was followed by a second meeting in February 2015, supervised by the Organization for Security and Cooperation in Europe (OSCE) and attended by the leaders of France, Germany, Russia and Ukraine.
It called for an immediate ceasefire, the removal of heavy weaponry, a 50-kilometre security zone between the two sides, amnesties and the release of prisoners, elections with a temporary law of self-governance in the occupied regions, and Ukrainian control of the state border by the end of 2015. Monitoring of the agreement was in the hands of OSCE observers. The summit gave some credibility to the leaders of the so-called Donetsk People's Republic (DPR), Aleksandr Zakharchenko, and Luhansk People's Republic (LPR), Igor Plotnitsky.
Three years later, the ceasefire technically is in place but fewer provisions of the Minsk Protocols have been followed. About 11,000 people have died, and a further 1.5 million have fled the region, to other areas of Ukraine or to Russia. There are daily casualties in the conflict zone, mostly by shelling and rifle fire. The original militant leaders are gone: Girkin left in August, Plotnitsky fled Luhansk in November 2017 and Zakharchenko was killed by a bomb on August 31, 2018.
Yet Ukraine is nowhere close to resolving the dilemma. Alexander Motyl commented in The Kyiv Post in October 2014 that Ukraine should "[wash] its hands of the enclave that Russia and its proxies now control." Others consider Donetsk and Luhansk integral to Ukraine.
Two other factors should also be added: the first is the uniqueness of the Donbas, with its history of demands for autonomy. The second is Russia. There is ample evidence to suggest that Russia became disillusioned both with Girkin and Zakharchenko. Russia wishes to have more compliant figures at the helm. But Putin is reluctant to commence a full-scale war with Ukraine.
Some Russian goals are clear: Ukraine should not join NATO or European structures. Its navy controls the Azov Sea, and completed a 227-metre bridge linking the Krasnodar region to Crimea, and it continues support to the DPR and LPR regimes.
Putin favours the use of UN peacekeeping forces in Donbas but insists that Ukraine must communicate directly with the leadership of the two republics. Thus far, Ukraine has refused to do so. The future of this region, the heartland of Ukrainian industry, remains in doubt, not least because of the lack of clarity in the policies of the major actors involved. It remains the single most intractable political problem in contemporary Europe.
David R. Marples is a professor of Russian and East European history in the Department of History and Classics.
A version of this opinion-editorial appeared Oct. 30 in the Edmonton Journal.


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Whole Wheat Cinnamon Cookies
1/2 cup butter, softened
1/2 cup shortening
1 1/2 cups white sugar
2 eggs
2 teaspoons vanilla extract
1 1/4 cups whole wheat flour
1 1/2 cups all purpose flour
2 teaspoons cream of tartar
1 teaspoon baking soda
1/4 teaspoon salt
2 teaspoons ground cinnamon
Preheat oven to 400 degrees F
Cream together butter, shortening, sugar, the eggs and the vanilla. Blend in the flour, cream of tartar, soda, salt, and cinnamon. Scoop spoonfuls onto greased cookie sheet. Place 2 inches apart on ungreased baking sheets.
Bake 8 to 10 minutes, or until set but not overcooked. Remove from baking sheets.
for a printer frendly version of this page.


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Digital technologies will give Cambodia the opportunity to leapfrog traditional stages of development, but it will take the country at least 10 years to complete the transition into a full-fledged digital economy, the minister of economy and finance said yesterday.
Speaking during a two-day national consultation workshop on Cambodia's digital economy, Minister Aun Pornmoniroth said the country's digital economy has been taking shape gradually, with new businesses joining the digital payment, online entertainment and e-commerce sectors every year.
The workshop, being held at Phnom Penh Hotel, started yesterday and will continue today, with participants from the World Bank, Alibaba Group and King & Wood Mallesons, among others.
Mr Pornmoniroth also pointed out that Cambodians are quickly familiarising themselves with new technologies, and added that to reap the most benefits out of the current digital transformation countries must have the ability to quickly adapt to change.
"For developing countries like Cambodia, new technologies provide an opportunity to leapfrog, bypassing traditional phases of development," the minister said.
"In the context of globalisation and global integration, Cambodia certainly cannot avoid the impact of the Industrial Revolution 4.0, and that requires the government to focus on seizing opportunities as well as managing risks," he said.
However, he said the country's digital capabilities are still at a nascent stage. "Cambodia may need to spend the next five years building the pillars of a digital economy, and will probably spend another five to ten years growing that digital economy and aiming for a technology-driven market," he said.
"In this regard, it is worth clarifying that Cambodia has no intention to create a Silicon Valley or a unicorn startup company. Our vision is to create a robust digital environment that allows both small and large firms in the country to connect to global value chains," he added.
Mr Pornmoniroth said the government will need time to build the necessary soft and hard infrastructure and the regulatory environment, promote digital literacy, and enhance e-government capabilities.
"The government has to be prepared for the digital age and to create a supportive ecosystem that can foster the transformation of the economy.
"To this end, the government will develop and implement a long-term strategic framework, serving as a guide and overall framework for the development of the digital economy," he added.
Vongsey Vissoth, chairman of the digital economy policy working group and secretary of state at the Ministry of Economy and Finance, said, "Today's gathering represents an invaluable opportunity to exchange dialogue and perspectives on some key issues, share experiences, and gather inputs, all of which would be useful and relevant for Cambodia to prepare a long-term digital development framework to sustain the success of Cambodia's socio-economic development."
Ellen Goldstein, World Bank country director, issued a set of recommendations to the Cambodian government.
First, she said, Cambodia needs to find new drivers of growth, as the country will not be able to rely exclusively on traditional sectors in the future.
She said digital technology will be central to efforts to diversify drivers of growth, and added that the country's next economic transformation will rest on its ability to empower domestic entrepreneurs and citizens with capabilities and tools for the economy of tomorrow.
"Moving forward, the country will need targeted policies to reinforce the basis upon which a digital economy can thrive," she said, adding that Cambodia must strive to close the digital divide by developing an effective strategy.
According to the data from the Telecom Regulator of Cambodia (TRC), in 2018 Cambodia had 19.5 million mobile subscribers from 6 mobile operators – of these 13.6 million used the Internet from their mobile phones and about 7 million had Facebook accounts.
- Tags: Aun Pornmoniroth, Development, digital, economy, technologies


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Splatoon Discount Offered to Global Testfire Players
If you took part in one of the multiple Splatoon Global Testfires earlier this year, but still have yet to pick up Nintendo's squid-based shooter, now might be the time. A new advertisement on the eShop is promising a discount to those players who tried the game in one of its test phases.
The 20% discount is live on the Wii U eShop now through Nov 16 at 8:59 a.m. PST. While it may only apply to digital versions of the game, this is the first significant price cut available for Splatoon since it launched in May.


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Home Tags Banking sector jobs for engineers
Tag: banking sector jobs for engineers
Bank job after engineering? Here's why banking jobs make sense for engineers
Approx 15 lakh students pass out as engineers every year, out of which only 2-3 lakhs find job in an IT firm. As the IT sectors in India are limited and...


text: An Echocardiographer (or cardiac sonographer) is a health professional who uses a range of diagnostic tools, including ultrasonic equipment, to produce diagnostic images, video loops, laboratory data and three dimensional and four dimensional volumes of cardiovascular anatomy. You will undertake a four-year full-time course of study, comprising a three-year undergraduate Bachelor of Echocardiography (Cardiac Physiology) and a one-year Graduate Diploma of Echocardiography. You will be able to apply your knowledge of cardiac physiology, measurement science and practical echocardiographic scanning skills in the diagnostic setting.


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凯时kb88.comApril 21 -- 27, Shanghai Jiao Tong University
Home || Participants || Track A : Spherical Design and Numerical Analysis || Track B : Graph Homomorphisms and Dynamical Systems || Direction
We are organizing a combinatorics week at Shanghai Jiao Tong University during April 21 - 27, 2015. Our talk schedule will not be too crowded, in order to have ample time for discussions among the participants. Besides usual conference talks, we will also arrange some talks as public lectures and introductory short courses.
This event basically consists of two tracks, track A from April 21 morning to 24 noon and track B from April 24 noon to 27. The main topic of track A is the interplay between design theory and numerical analysis with special emphasis on spherical designs and approximations of integrals on the sphere. Our track B will focus on the concept of discrete dynamical system, emphasizing it as a unifying language and viewpoint for a wide spectrum of mathematics and its applications.
凯时kb88.comLike all scientific events organizers, we intend to bring together various kinds of persons for a fruitful exchange of ideas and we invite folks who have something cool to say to just come and say it. We encourage undergraduate students join us for a week of fun.
If you are interested in giving a talk or joining us without giving any formal planned talk, please contact Eiichi Bannai (email@example.com) or Yaokun Wu (email@example.com). We will also welcome some talks which are not so closely related to the theme of our two tracks. Announcements for related talks around the workshop period can be found at our Combinatorics Seminar website.
凯时kb88.comWe reserve seminar room No. 4 in Building 3 of the campus hotel for free discussions in the following slots:
April 21, 19:00 - 23:00; April 22, 13:00 - 17:00; April 23, 15:00 - 23:00; April 25, 19:00 - 23:00; April 26, 19:00 - 23:00; April 27, 15:00 - 23:00


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It wouldn't be Nordic Fest without lots of entertainment for the whole family. Walk down Water Street any time of the day or night and find music groups entertaining the crowds. The Nordic Dancers perform throughout the Fest. Take it all in!
Please check schedule for complete listings.
Nordic Dancers
The Nordic Dancers have been a core part of Nordic Fest from the beginning. This fun group of young folk dancers helps us remember the traditional folk dances of Scandinavia. They are accompanied by the Nordic Dancers Orchestra and perform multiple times during the Fest.
Beverage Garden
Head over to the Beverage Garden after a day of Festing to take in amazing music, meet other Festers, and enjoy a cold beverage. There is a $5 cover charge for Beverage Garden entertainment.


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Weatherby moved to the Falcon works from a smaller works in Tunstall in 1892. The factory was in the Weatherby family until closure in 2000. The works made everything from fancy goods to domestic ware, but their main lines were in Hotel and crested ware.
One of the last remaining family-owned pottery firms is to close after more than a century.
J H Weatherby and Sons in Hanley is currently being run down and is will soon cease trading after 109 years.
Its chairman, Christopher Weatherby, the great-great grandson of company founder John Henry Weatherby, today blamed cut-throat competition in the hotelware business for the firm's decline.
At its height the company employed 200, but the figure was down to 50 at the turn of the year and now stands at 10.
Mr Weatherby said: We have decided to cease trading and are in the process of finishing off stock and things like that.
Basically we've decided to close down before someone else forced us to while we are solvent rather than insolvent.
It's really upsetting. One of the main reasons is for the employees who work here.
We have had two or three generations of people working here and one of the things I've found warming is their reaction to this.
They have been very sympathetic and understanding. Everyone who works here has been very happy here.''
The company was founded in Tunstall in 1891 and moved to Hanley the following year.
It first made domestic ware such as basins and ewers, later moving into tableware and giftware.
The firm also entered the market for hotelware leading ultimately to its downfall.
Mr Weatherby pointed to tough competition from home and abroad for the company's current problems.
These included pressure on prices owing to block production'' and the concentration of the business in relatively few hands.
The 59-year-old added: The hotel part of it was more fragmented. That has been changing and it's relying on more standard patterns.''
Mr Weatherby admitted the firm had even considered importing cheaper products from abroad, but was deterred because of the high volumes needed to make the operation profitable.
This route was controversially followed by another failed family firm, James Sadler and Sons.
Although the Burslem-based family firm went under earlier this year with the loss of 140 jobs, James Sadler Imports Limited continues to trade.
Mr Weatherby also partly blamed a planning issue dating back to the early 1970s, which blighted'' the family firm and restricted investment in it.
After finishing work early one afternoon and nothing else to do, into Weatherbys I went, then returning on the Saturday with a friend.
On with the pics
The full set is: http://s1087.photobucket.com/albums/...ok/Weatherbys/
Thanks for looking


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Is It Time to Re-think Your InMail Approach?
Are you sabotaging yourself when using LinkedIn InMail to prospect new business? Or is your team spinning wheels, generating less than the minimum 40 percent response rate? It might be time to re-think your InMail communications approach.
Here are three deadly trends I see emerging with sellers and what to do instead.
Are you/your sellers:
- Believing InMail is more "powerful" (able to produce appointments) than cold calling or standard email?
- Investing in LinkedIn training, but overlooking communications methodology?
- Using InMail to request meetings with status quo buyers, but failing to earn them?
Many sellers are getting frustrated out-of-the-gate. Because InMail places so much pressure on getting response. Performance. Sellers often get turned-off to prospecting in general! Or they become more turned-off by it.
It's best to develop a successful communications approach using standard email — then bring that success to the realm of InMail.
A Better Way to Use InMail When Prospecting
Any written message's strength is founded in the writer's ability to provoke a response that invites a conversation. The better you are at provoking replies — that lead to conversations — the more InMail provides advantage.
That's a communications thing; not a LinkedIn thing.
I'll be brutally honest. Many sellers are failing to develop new business leads with InMail. Not because LinkedIn Navigator or Premium is a bad investment. It can be a good one. The trouble starts with false beliefs.
Beware if you think InMail is
- powerful
- better than standard email
- able to replace cold calling efforts
Remember, LinkedIn does not make any substantiated claims about better response. InMail is also not trackable. Unlike standard email, you cannot track any open or click activity! (This is huge)
Attract Buyers With Your Message
We're only human. We are all looking for a short cut to what we want. Something that will do all the work for us or — in some way — produce better results with less effort. Right? But for most of us InMail is not earning better response from potential buyers.


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Crowdsourcing platform for design projects
Christiaan Huynen, a design professional and founder of Cartils Design in London, reached out to the UGEM design team with an idea for DesignBro, a quality-oriented design crowdsourcing marketplace that brings together businesses and professional designers.
Project Profile
Customers who want to choose from a variety of design concepts quickly and at affordable prices.
Designers who want to participate in contests with transparent terms and high chances of winning.
Design Objectives
The idea behind design crowdsourcing is brilliant, as it lets businesses get designs they need at affordable prices. Most design crowdsourcing platforms, however, face a quality issue: they let in lots of low-skilled designers who produce low-quality designs. The founder of DesignBro wanted to fix this problem by building a design crowdsourcing marketplace focused on quality.
Establishing Efficient Communication
Understanding contest requirements is key to successful collaboration between customers and designers. Therefore, our team focused on implementing easy-to-use communication tools that allow customers to translate their desires into exact design requirements.
Increasing Conversions
DesignBro is a marketplace, so it needs to attract users – both customers and skilled designers. Our team needed to come up with an appealing interface and streamlined flow to promote conversions.
Visually Appealing User Interface
After testing several concepts, we created a minimalist UI with mostly neutral colors – black and white along with some gray. To highlight important information such as contest statuses, notifications, and pricing, we used more eye-catching colors such as pink.
Intuitive Design Briefs
To receive relevant design concepts, customers have to provide detailed descriptions of what they want. In collaboration with Christiaan, we created a simple and straightforward design brief that requires little time to fill out and helps customers easily describe project requirements.
Create the Brief
Tracking Contest Progress
DesignBro users can track the progress of contests to help manage their time. Designers can easily check the status of contests and decide whether to participate, and customers can stay updated about progress and get to a winning design faster.
Spot Reservations for Designers
DesignBro limits the number of designers who can participate in a contest. This helps provide customers with an optimal number of high-quality concepts to choose from and, moreover, increases the chance of winning for designers. Therefore, designers need to be informed whether they can join a competition. Our team came up with a simple yet informative spot reservation form.
Thanks to the deep expertise of UGEM design team we created a fully functional design crowdsourcing marketplace that offers trully satisfying customer experience. UGEM will definitely go an extra mile with you to achieve the best possible result and meet your business needs.
DesignBro, Founder


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Festival musica 2015
Thursday 24 September, 8.30 pm, France 3 Alsace Auditorium, Strasbourg
Introduction to a Raphaël Cendo composition which echoed one of radical 80s icon Helmut Lachenmann's major works. This journey with the French composer and Ensemble Linea opened up a whole range of new perspectives.
"Movement (– before paralysis) is a music of dead movements, of almost final quivers, the pseudo-activity of which consists of nothing more than rubble…like a beetle floundering on its back." This is how Helmut Lachenmann – who turns 80 this year – described the composition in his program note. These words continue to encapsulate the essence of the German composer, who went on to become an influential – albeit controversial – reference for several generations in the quest for new sounds. Lachenmann explains how he proceeded to reinvent musicians' gestures and sound creation in order to transform his art: "only reincluded, unalienated sound can demonstrate that what is at stake is not the mere refraction of the sounds played externally, but an opening up and renewal of our internal practices of perception."
Any major work requires complete dedication on the part of its performers and a questioning of their preconceived notions. Musica has been presenting Raphaël Cendo's works regularly since a "young creator's" concert in 2006. Cendo's music doesn't seem to have any overt connections with that of Lachenmann, but it stems from the same quest for the truly radical. In Strasbourg, two of his masterpieces, Introduction aux ténèbres (performed in 2010) and Registre des lumières (in 2014) gave an impressive glimpse into the composer's interrogations: "Light is no longer the metaphor for knowledge, thought and creation," he said in 2009, "in today's day and age what still holds meaning is what is hidden, buried far from the blinding lights. Shadows still maintain their mystery. (…) to plunge the listener into darkness, yes, but only to better unleash its radiance, its blaze and fury." His presentation in 2015 sought to further enlighten the listener on the current state of his questioning.
Raphaël Cendo, Corps, 2015, World premiere (27')
Helmut Lachenmann, Movement (– before paralysis), 1982-84, (24′)
Jean-Philippe Wurtz: Conductor, Wilhelm Latchoumia: Solo piano, Keiko Murakami Flute 1, Ayako Okubo Flute 2, Heidi Caillet Oboe, Andrea Nagy Clarinet 1, Laurent Will Clarinet 2, Adam Starkie Clarinet 3, Antoine Pecqueur Bassoon, Samuel Stoll Horn, Stephen Altoft Trumpet 1, Julien Wurtz Trumpet 2, Thierry Spiesser Trombone, Olivier Maurel Percussion, Antoine Josselin Percussion, Victor Hocquet Percussion, Marco Fusi Violin 1, Winnie Huang Violin 2, Elodie Gaudet Viola 1, Marco Fusi Viola 2, AskarIshangaliyev Cello 1, Elsa Dorbath Cello 2, Sven Kestel Double bass, Elisabeth Bigot Piano.
Lived silence
Tuesday 17 November 2015, Théâtre de Cornouaille, Scène nationale de Quimper, France
Contemporary composer Aurélien Dumont was artist-in-residence at the Théâtre de Cornouaille music center for two seasons.
For Ensemble Linea's performance at the Théâtre de Cornouaille, Aurélien Dumont presented a rich program reflecting a diversity of references. Under the direction of conductor Jean-Philippe Wurtz, Ensemble Linea led the way to a discovery of compositions by Dumont and his musical inspirations such as Claude Debussy and Gérard Pesson. In this "calling card" performance, Aurélien Dumont's music is thought out like a time slider, like a mapping project composed of small landscapes scattered with unexpected musical objects ranging from Japanese culture, music from the past to contemporary poetry. Ensemble Linea shares the composer's affinity for Japan and its ability to combine radical modernity and tradition with seeming atemporality. Similarly, the composer and the ensemble have a common conception of sonic precision and a shared fascination for the encounter of various aesthetic disciplines and musical generations. The result is an amalgamation where the works of Dumont enter into resonance with those of his ancestors, such as his teacher Gérard Pesson or Debussy and Webern. In an arrangement that holds up a mirror to the concert experience itself, Aurélien Dumont alternates chamber music and silent videos by Jennifer Douzenel, an artist whose work held special meaning for the composer. Dumont's goal is not to use the music or the images to illustrate each other, but to present the videos as a kind of lived silence, one that recalls the delicate and ephemeral stillness that prevails right after the performance of a musical piece.
Aurélien Dumont, Berceuse et des Poussières, 2012(13')
Aurélien Dumont, Sérieux gravats, 2010 (16')
Aurélien Dumont, Fiocchi di silenzio, 2014 (2')
Claude Debussy, Ce qu'a vu le vent d'Ouest (Book I)
Claude Debussy, Ondine (Book II)
Salvatore Sciarrino, Study for violin, 1976 (18')
Gérard Pesson, Ne pas oublier coq rouge dans jour craquelé, 2010 (10')
Anton Webern, Opus 7, 1910 (5')
Jean-Philippe Wurtz Conductor, Chie Otsuka Piano, Keiko Murakami Flute, Adam Starkie Clarinet, Thierry Spiesser Trombone, Malika Yessetova Violin, Elodie Gaudet Viola, Johannes Burghoff Cello, Victor Hocquet Percussion.
Oversea III
2 to 21 April 2016, Ensemble Linea's US Tour
After its first ventures onto American territory with the Overseas 2011 and 2013 tours, Ensemble Linea returns to the United States for a new season of concerts, workshops and encounters across four cities: Pittsburgh, Buffalo, New York (for the MATA festival) and finally Chicago.
Through Overseas III, Linea provides an overview of the French contemporary music scene by presenting the works of talented composers such as Cendo, Durieux, Dumont, Sannicandro and Dusapin. The world premiere of the third movement of Frédéric Durieux's Etudes en alternance was much-acclaimed by American audiences, especially in Pittsburgh, known for being an experimentation and innovation hub.
Education, creative exchange and cooperation were a key component of Overseas III, with Linea developing collaborations with several American universities. In addition to concerts presenting the French repertoire of contemporary music, Linea was also artist-in-residence at the Universities of Pittsburgh, Buffalo and Chicago Northwestern. The Ensemble was thus on hand for the young composers training at these universities, going on to present their works – most of which as world premieres – at the closing concerts of each residency.
Linea was also invited to perform at the MATA Festival in New York, the leading showcase for "vital new music by emerging composers". In concert at the National Sawdust, Linea performed the works of young American composers commissioned by the Festival.
As such, Overseas III consolidated Linea's presence in the United States where the ensemble has already gained some recognition by a section of the media and music professionals. The tour was also an opportunity for Linea to continue its exchanges and deepen its understanding of the current American repertoire, which will inform its future projects in France and Europe, just as the first and second editions of the tour led to performances of American music concerts by the Ensemble at Festival Musica in 2012 and at the Arsenal de Metz in January 2014.
All in all, Overseas III is a confirmation of Linea's commitment to concrete and long-term collaborations with musicians and organizations in the United States of America.
2 and 4 April 2016, Andy Warhol Museum, Pittsburgh
Raphaël Cendo, Rokh I, 2011-12 (15')
Aurélien Dumont, Fiocchi di Silenzio, 2014 (2')
Valerio Sannicandro, Constructa, (11')
Marco Momi, Iconica, 2010 (12')
Pascal Dusapin, Indeed, 1987(9')
Frédéric Durieux, Études en alternance 1, 2, 3 (n°3 en Création mondiale) (17')
+ Works by composition students performed by Ensemble Linea:
Ramteen Sazegari (String trio with trombone), Laura Schwartz (piano, viola, trombone) Jason Belcher (violin, clarinet, trombone, vibraphone), Xinyang Wang (flute, clarinet, piano, violin, cello) Lu-Han Li: (trombone, cello), Brian Riordan (flute, clarinet, violin, cello), Ryan McMasters (new piece), Jeff Weston (violin, viola, cello).
6 April 2016, Lippes Concert Hall – The Robert and Carol Morris Center for 21st Century Music, Buffalo
Raphaël Cendo, Rokh I, 2011-12 (15')
Aurélien Dumont, Fiocchi di Silenzio, 2014 (2')
Valerio Sannicandro, Constructa, (11')
Marco Momi, Iconica, 2010 (12')
Pascal Dusapin, Indeed, 1987(9')
Frédéric Durieux, Études en alternance 1, 2, 3 (n°3 en Création mondiale) (17')
+ Works by composition students performed by Ensemble Linea:
Alex Huddleston (NY), Roberto Azaretto (NY), Matt Chamberlain (NY), Meredith Gilna (NY), Su Lee (NY), Weijun Chen (NY).
11 and 13 April 2016, New York – MATA Festival, National Sawdust
Yair Klartag, New work for Linea, flute, clarinet, trombone, violin, viola, cello, piano – world premiere
Zeno Baldi Mimo – clarinet, piano, violin, viola, cello (10')
Scott Wollschleger, America – solo cello (8')
Utku Asoruglu flute, clarinet, trombone, violin, viola, cello, piano – world premiere
Weijun Chen New work
Arash Yazdani Demodulation, flute, clarinet, oboe, violin, viola, cello (11′)
Michelle Agnes Magalhaes, Mobile, prepared piano (7')
18 and 21 April 2016, Mary B. Galvin Recital Hall – Bienen School of Music/ Institute for New Music – Northwestern University, Chicago
Raphaël Cendo,Rokh I, 2011-12 (15')
Aurélien Dumont, Fiocchi di Silenzio, 2014 (2')
Valerio Sannicandro,Constructa, (11')
Marco Momi, Iconica, 2010 (12')
Pascal Dusapin, Indeed, 1987(9')
Frédéric Durieux, Études en alternance 1, 2, 3 (world premiere of n°3) (17')
+ Works by composition students performed by Ensemble Linea:
Morgan Krauss (violin, viola, cello, piano), Carlo Diaz (piccolo, bass clarinet, cello), Michal Raymond Massond (flute, clarinet, trombone, percussion, piano, violin, viola, cello, piano) Wilson Smith (flute, bass clarinet, trombone, violin, viola, cello, piano), Jose Miguel Arrelano (flute, clarinet, trombone, percussions, piano, violin, viola, cello), Noah Jenkins (flute, clarinet, trombone, piano, violin, viola, cello).
Jean-Philippe Wurtz Conductor, Keiko Murakami Flute, Andrea Nagy Clarinet, Thierry Spiesser Trombone, Marco Fusi Violin, Elodie Gaudet Viola, Johannes Burghoff Cello, Claudia Chan Piano, Frédéric Durrmann Stage manager.
Festival manifeste 2016
Thursday 16 June 2016 – Festival ManiFeste – Paris, France
Ensemble Linea was invited to IRCAM's ManiFeste Festival for an exclusive concert at the Centre Pompidou on 16 June 2016. Three original works by Philippe Manoury, Rebecca Saunders and Emanuele Palumbo were performed.
Pierre Boulez often returned to his own works throughout his career, concretizing the latent idea behind or giving unexpected new meanings to the original and hidden "unbreakable core". In his tribute to Pierre Boulez, it is Philippe Manoury's turn to return to the erstwhile composer's work Partita (2012) for violin and electronic by adding instrumental sections. In B-Partita, the instrumental ensemble joins and surrounds the original core constituted by the solo violinist and electronics. Multiple meters exist simultaneously in a dialogue between the soloist and the electronics as the real meets the virtual through the magic of technology.
In a completely different aesthetic vein, Rebecca Saunders extends her solo work Fury for solo double bass by diffracting it through an instrumental ensemble in low registers. Inspired by the five-string configuration of the double bass, Fury II displays a unique fascination for pulsating and deep sounds, the vast percussive potential of the instrument and the pronounced and passionate movements of the solo double bassist. At the same time, the composition also explores the fragility of the instrument in the higher registers – its delicate, ethereal sounds creating an antithesis, a counterpoint of shadows. The seething soundscape is conceived as a silence from which pent-up sounds emerge and return beneath the surface. Despite Fury II's apparent aggression, a nebulous melodic line emerges, ceasing just before reaching its zenith.
Emanuele Palumbo, on the other hand, attempts to combine "objective" with "fluctuating" tempo, the latter coming from none other than the heart rates of the individual performers. The musicians are fitted with cardio-sensors connected to metronomes, thus providing the ensemble with audible tempos that are integrated into the musical discourse. The audience is invited to follow the physiological parameters of three of the nine instrumentalists, playing the flute, percussion and cello respectively. Each of these musicians is at the core of sub-ensembles, each developing polyphonic textures combining objective and fluctuating tempos in a multitude of permutations. At the same time, the inputs received from the three musician's hearts is interpreted and manipulated by the ensemble to create an expressive and perceptible form.
Philippe Manoury, B-Partita (tribute to Pierre Boulez), Premiere, 2015-2016 (23')
Rebecca Saunders, Fury II, French premiere, 2009 (13')
Emanuele Palumbo, Artaud overdrive, Premiere, 2015-2016 (18')
Jean-Philippe Wurtz Conductor, Hae Sun Kang Solo violin, Florentin Ginot Solo double bass
Stephen Altoft Trumpet, Lise Baudouin Piano, Johannes Burghoff Cello, Heidi Caillet Oboe, Remi Durupt Percussion, Marco Fusi Violin, Elodie Gaudet Viola, Deepa Goonetilleke Horn, Winnie Huang Violin, Marie-Andrée Joerger Accordion, Benoît Maurin Percussion, Keiko Murakami Flute, Andrea Nagy Clarinet
Frédéric Durrmann Stage manager, Serge Lemouton, Emanuele Palumbo IRCAM computer music designers, Marco Liuni IRCAM academic and scientific support, Jean-Julien Aucouturier, Emmanuel Fléty, Arnaud Recher, Frédéric Bevilacqua, Joseph Larralde STMS-IRCAM scientific and technical advisors


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Tuesday, April 10, 2007
Generations of love...
people have asked who those two little girls were in my post about Easter??? yes, the are my great nieces Addison and Karissa. I am now babysitting Addison ( the little sweetie) full time. After selling antiques for 18 years I decided to take a break and was asked to babysit...I must admit it was an adjustment at first, but now she is just a part of me and my day and we are having so much fun together shopping and going out to lunch and of course visiting great grandma! Addison is very special to me, her grandma Diane (my sister) passed away from cancer at the age of 46 and never got to meet Karissa and Addison...my sister was my best friend and I miss her everyday.
Posted by the tattered nest at 3:54 PM
3 comments:
- Retroboutiques said...
They are absolutely adorable!
- April 10, 2007 at 4:44 PM
- Unknown said...
Gail, they are beautiful! And your nieces are so blessed to have you - it's obvious you love them very much.
allie from minneapolis
- April 14, 2007 at 11:17 AM
- Laurie said...
I am getting caught up in your blog. Your nieces are just beautiful. I am so sorry your sister Diane passed away. Life is just not fair at times and I would say that your sister's spirit is living in you and smiling down from heaven. What a blessing you all are to each other.
- June 29, 2007 at 7:35 AM
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Quiet Storm to highlight exploitation of trafficked women
Quiet Storm has won the advertising account for human rights action group The Helen Bamber Foundation without a pitch. The first work will break later this week.
The campaign, called Lost in F**king Transition, aims to highlight the cruelty and exploitation suffered by illegally trafficked women who are shipped to the UK to work as sex slaves. Actress Emma Thompson stars in the campaign, which has been made with The Body Shop.
The ads focus on the high number of foreign prostitutes in London. It claims that one in four prostitutes in the capital were from outside the UK ten years ago, but that this is now three out of four.
The campaign includes a cinema ad and a hard-hitting viral campaign, which shows Thompson on a bed, in two perspectives, with a graphic shot from the view of an assailant.
During the ad, she recounts two sets of memories: those of Elena, a young women hoping to learn English and become a nurse, and those of Maria, a prostitute who is often forced into as many as 40 sex acts a day. As the film ends, Thompson reveals Maria and Elena are the same – a before and after snapshot of a life destroyed. It ends with the strapline "Trafficking is torture".
The cinema execution shows how foreign women are not allowed to integrate with society and are only able to communicate what they hear during their entrapment, so can only express themselves by using shocking and degrading language.