text:
The ambiguous statement by President Sata on the sale and distribution of machetes leaves much to be desired.
Speaking to a caucus at State House yesterday, the President is reported to have demurred over the sale and distribution of machetes because some Zambians would be deprived of their livelihood.
The President obviously or deliberately missed the point to avoid the issue of panga wielding PF militia.
According to Malawian President Joyce Banda, who was at the funeral of Africa Icon, Nelson Mandela, leaders must genuinely fall in love with the people they serve, and become servant leaders. Zambians are in mourning over the death of a young life lost in very violent circumstances, in which machetes were used, and the inability of the President to categorically speak out against violence and the acquisition and use of machetes in political coersion, brings into doubt, Mrs Banda's admonishment to her fellow leaders.
The police have failed to tell the nation the source of the violence and machetes' which were used by a militia which had been supplied in a well organised and financed militia operation, to cause death and mayhem.
Zambians are naturally, concerned by the proliferation and abuse of machetes as now being used as offensive weapons in political confrontation as was the case resulting in the death on one Moses Simuwela whose cause of death although in doubt was the direct result of a violent confrontation in which these offensive weapons were used.
Like all Zambians we would have appreciated the President shedding some light on the incident that resulted in a panga wielding militia terrorising Lusaka and in the process injuring and maiming many Zambians. There has been no explanation from this government about this incident. Nobody has explained where the machetes came from, who bought them in bulk, who distributed them to the militia that went into town wielding them.
But perhaps more importantly who masterminded this attack.
The police must know the ring leader of this militia and if we cannot be told now we shall wait for an appropriate time, perhaps after this regime, to find the truth.
The police and all those responsible for security must know that it is not an easy matter to hide circumstances that lead to a death especially the death of a young, vibrant and very healthy individual of 18 years. Nobody, least of all we at the Daily Nation, believe that Simuwela could have died of natural causes unless ofcourse such causes were brought about by a deliberate truncation of normal physical systems. But this can hardly be called natural causes.
Like Simuwela's parents, we are waiting for information on this matter and like the rest of the nation we want to get to the bottom of the panga wielding militia that held this city captive. On that fateful Thursday and indeed on the following day when the city remained jittery and police were forced to move from one precinct to another assuring citizens that there was no more mayhem to be expected. This terrorism cannot go unpunished.
The wrist slaps being proposed by useless charges in courts of law will neither assuage nor provide comfort to Zambians who are genuinely interested in the peaceful well being of the nation where no individual should wield a panga against another without facing punishment.
That is why it is most unfortunate that the president has allowed an opportunity when he had all his patriotic front operatives at state house to offer counsel against violent conduct and impunity, to go begging. We should not wait for another "war", this time perhaps amongst parties, to erupt before we shed crocodile tears. The time is now to deal firmly and decisively against law breakers.


text:
2017 Land Rover Range Rover HSE Full Size 4WD SUV Supercharged
Our Price $63,999
*This calculator is for informational use only and is based on the information you provide. Actual loan amounts and payments will vary based on additional items such as taxes and fees as well as the actual interest rate available to you from a financial institution.
- Exterior
- Corris Grey
- Interior
- Black Leather
- Engine
- Engine: 3.0L V6 Supercharged -inc: intelligent stop/start
- Transmission
- Automatic
- Drivetrain
- 4 wheel drive
- Mileage
- 29,628
- City / Hwy
- 17 / 23
*Actual rating will vary with options, driving conditions, habits and vehicle condition.
- Warranty
- Limited Warranty
- Stock
- 362943
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Call or Text JBA MOTORS at 480-599-6830
*Please check our website for vehicle history information*
2017 Land Rover Range Rover HSE 4WD SUV - like the Sport Supercharged SC HSE 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
Standard Equipment
- Window Grid And Roof Mount Diversity Antenna
- Voice Recorder
- Voice Activated Dual Zone Front Automatic Air Conditioning w/Steering Wheel Controls
- Valet Function
- Trunk/Hatch Auto-Latch
- Trip Computer
- Systems Monitor
- Smart Device Remote Engine Start
- Seats w/Leatherette Back Material
- Remote Releases -Inc: Proximity Cargo Access and Keyfob Rear Window
- Remote Keyless Entry w/Integrated Key Transmitter, 4 Door Curb/Courtesy, Illuminated Entry and Panic Button
- Redundant Digital Speedometer
- Rear HVAC w/Separate Controls
- Rear Cupholder
- Real-Time Traffic Display
- Radio: 380 Watt Meridian Audio w/10.2" Touchscreen -inc: 13 speakers, Bluetooth phone connectivity w/audio streaming, InControl Pro services for warranty period (includes WiFi), InControl Touch Pro infotainment, satellite and HD radio and InControl apps
- Radio w/Seek-Scan, Clock, Speed Compensated Volume Control, Steering Wheel Controls, Radio Data System, Weatherband and DVD-Audio
- Proximity Key For Doors And Push Button Start
- Power Tilt/Telescoping Steering Column
- Power Rear Windows and Fixed 3rd Row Windows
- Power Fuel Flap Locking Type
- Power Door Locks w/Autolock Feature
- Power 1st Row Windows w/Driver And Passenger 1-Touch Down
- Perimeter Alarm
- Passenger Seat
- Outside Temp Gauge
- Metal-Look Gear Shifter Material
- Memory Settings -inc: Door Mirrors and Steering Wheel
- Manual Anti-Whiplash w/Tilt Front Head Restraints and Manual w/Tilt Rear Head Restraints
- Leather Door Trim Insert
- Interior Trim -inc: Genuine Wood Instrument Panel Insert, Genuine Wood Door Panel Insert, Genuine Wood/Metal-Look Console Insert, Aluminum/Metal-Look Interior Accents and Leather Upholstered Dashboard
- Interior Lock Disable
- Integrated Navigation System w/Voice Activation
- Instrument Panel Covered Bin, Driver / Passenger And Rear Door Bins
- InControl Secure Tracker System
- Illuminated Locking Glove Box
- HVAC -inc: Underseat Ducts, Residual Heat Recirculation, Headliner/Pillar Ducts and Console Ducts
- HomeLink Garage Door Transmitter
- Heated Leather/Metal-Look Steering Wheel w/Auto Tilt-Away
- Heated Front Bucket Seats -inc: 14-way driver and passenger seat, electric lumbar, driver's seat memory and front climate seats (cooled) w/adjustable bolsters
- Gauges -inc: Speedometer, Odometer, Engine Coolant Temp, Tachometer, Altimeter, Oil Level, Trip Odometer and Trip Computer
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- Front Cupholder
- Front And Rear Map Lights
- Folding Cargo Cover
- FOB Controls -inc: Cargo Access, Windows, Sunroof/Convertible Roof and Air Suspension
- Fade-To-Off Interior Lighting
- Engine Immobilizer
- Driver Seat
- Driver Foot Rest
- Driver And Passenger Visor Vanity Mirrors w/Driver And Passenger Illumination, Driver And Passenger Auxiliary Mirror
- Driver And Front Passenger Armrests Front Center Armrest w/Storage and Rear Center Armrest w/Pass-Thru w/Storage
- Digital/Analog Display
- Digital Signal Processor
- Delayed Accessory Power
- Day-Night Auto-Dimming Rearview Mirror
- Cruise Control w/Steering Wheel Controls
- Compass
- Carpet Floor Trim and Carpet Trunk Lid/Rear Cargo Door Trim
- Cargo Space Lights
- Cargo Area Concealed Storage
- Automatic Equalizer
- Audio Theft Deterrent
- Air Filtration
- 40-20-40 Folding Split-Bench Front Facing Heated Manual Reclining Tumble Forward Rear Seat
- 4 12V DC Power Outlets
- 2 Seatback Storage Pockets
- Wheels: 20" 5 Split Spoke Alloy - Style 502
- Tires: P255/50WR20 AS BSW
- Tailgate/Rear Door Lock Included w/Power Door Locks
- Steel Spare Wheel
- Speed Sensitive Rain Detecting Variable Intermittent Wipers w/Heated Jets
- Silver Grille
- Rear Fog Lamps
- Power Liftgate/Tailgate Rear Cargo Access
- Perimeter/Approach Lights
- Metal-Look Bodyside Insert and Body-Colored Bodyside Cladding
- LED Brakelights
- Laminated Glass
- Fully Automatic Projector Beam High Intensity Low/High Beam Daytime Running Auto-Leveling Headlamps w/Washer and Delay-Off
- Front Windshield -inc: Electrically Heated Glass and Sun Visor Strip
- Fixed Rear Window w/Variable Intermittent Wiper and Defroster
- Express Open/Close Sliding And Tilting Glass 1st And 2nd Row Sunroof w/Power Sunshade
- Door Auto-Latch
- Deep Tinted Glass
- Compact Spare Tire Mounted Inside Under Cargo
- Clearcoat Paint
- Body-Colored Rear Step Bumper w/1 Tow Hook
- Body-Colored Power w/Tilt Down Heated Auto Dimming Side Mirrors w/Power Folding and Turn Signal Indicator
- Body-Colored Front Bumper w/1 Tow Hook
- Body-Colored Door Handles
- Black Side Windows Trim and Black Front Windshield Trim
- Aluminum Panels
- Terrain Response Electronic Stability Control (ESC) And Roll Stability Control (RSC)
- Side Impact Beams
- Power Rear Child Safety Locks
- Outboard Front Lap And Shoulder Safety Belts -inc: Rear Center 3 Point, Height Adjusters and Pretensioners
- Low Tire Pressure Warning
- Lane Departure Warning
- Front And Rear Parking Sensors
- Forward Collision Mitigation
- Dual Stage Driver And Passenger Seat-Mounted Side Airbags
- Dual Stage Driver And Passenger Front Airbags
- Curtain 1st And 2nd Row Airbags
- Back-Up Camera w/Washer
- Airbag Occupancy Sensor
- ABS And Driveline Traction Control
- Transmission: 8-Speed Automatic -inc: steering wheel mounted paddle shift and 2-speed electronically controlled transfer case
- Towing Equipment -inc: Trailer Sway Control
- TBD Axle Ratio
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- 4-Corner Auto-Leveling Suspension
- 22.5 Gal. Fuel Tank
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- 1 Skid Plate
Option Packages
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- EBONY/EBONY/EBONY/EBONY, FULL OXFORD PERFORATED LEATHER SEAT TRIM Included
- CORRIS GREY Included
- PROTECTION PACKAGE -inc: Placed in cargo area, Rubber Mats, Retention Net, Loadspace Mat $556
- STANDARD PAINT Included
- VISION ASSIST PACKAGE -inc: Adaptive Xenon Headlamps w/LED Signature, Auto High Beam Assist (AHBA), All Terrain Progress Control (ATPC), Terrain Response 2, Configurable Interior Mood Lighting, Surround Camera System, Front Fog Lights $2,500
- RADIO: 825 WATT MERIDIAN PREMIUM SURROUND SOUND -inc: 19 speakers w/subwoofer $1,850
- PARK ASSIST -inc: parallel/perpendicular parking and park exit $925
- HEATED WOOD & LEATHER STEERING WHEEL -inc: Wood will match interior wood trim $500
- GRAND BLACK VENEER Included
- DRIVE PACKAGE -inc: Driver Condition Monitor, Traffic Sign Recognition w/Intelligent Spd Limiter, Blind Spot Monitor w/Reverse Traffic Detection $900

subset: commoncrawl


text: It's pretty simple… we're vested in Southern Illinois. It's where we live, it's where we raise our families, it's made of the communities we choose to support and it's where we CHOOSE to call home. It's special. (Here's where we get all mushy)… The holiday season is a time when most reflect upon their blessings and we're no different.


text:
January 2019
Jews Must Listen to the Fishermen To Obey The Command of God and return to Israel to wait for Messiah (HaMashiach) and to Avoid the Prophesied Persecution as spoken in the Scriptures Jeremiah 16:14-18 JPS (c)
Ed (Matrilineal Granofsky) Paradigm Zerubbabel And I will bless them that bless thee, and he that curseth thee will I curse;
From JPS © 1917 B'resheet (Genesis 12: 1- 3) Lekh L'kha (Get yourself out)
(Past) Now the LORD said unto Abram: 'Get thee out of thy country and from thy kindred, and from thy father's house, unto the land that I will show thee. And I will make of thee a great nation, and I will bless thee, and make thy name great, and be thou a blessing. And I will bless them that bless thee, and he that curseth thee will I curse, and in thee shall all the families of the earth be blessed.'\
(Past) Jews leave Egypt Sh'Mot (Exodus) 12:31-51
(Past) Jews leave Babylon Zerubbabel Ezra chapters 2- 5
Jews leave America (Paradigm is Babylon, Daughter of Babylon Zion,
Jeremiah 51:45
Zechariah 2:7
(Present) Yirmeyahu
(Jeremiah 16:14-18 JPS )
Lekh L'kha (Get yourself out) "Therefore, behold, the days come, saith the LORD, that it shall no more be said: 'As the LORD liveth, that brought up the children of Israel out of the land of Egypt,'
but: 'As the LORD liveth, that brought up the children of Israel from the land of the north, and from all the countries whither He had driven them'; and I will bring them back into their land that I gave unto their fathers. {P} Behold, I will send for many fishers, saith the LORD, and they shall fish them; and afterward, I will send for many hunters, and they shall hunt them from every mountain, and from every hill, and out of the clefts of the rocks.
For Mine eyes are upon all their ways, they are not hid from My face; neither is their iniquity concealed from Mine eyes. And first I will recompense their iniquity and their sin double; because they have profaned My land; they have filled Mine inheritance with the carcasses of their detestable things and their abominations.
(Jeremiah 16:14-18 JPS )
I am a fisherman calling in love for those of my people who need to make Aliyah. The hunters are beginning to hunt. It is the 11th hour. Robert Bowers, who killed 11 in Pittsburg, is only one of the signs of the hunters. The same demonic powers that controlled the minds of the Germans in the 30's and early 40's are now controlling the minds of the majority of America. The hunt has begun and it will increase as it did at Kristallnacht.
Violent attacks against U.S. Jewish community doubled last year, report says
Anti Semitism In in Califiornia
Prepare to leave your native countries and return to Israel and wait for HaMashiach.
With the Love of Yeshua for His People


text:
Welcome to our Tribe!
When you join one of our courses you automatically become part of our Serene Mummy Tribe.
When you join our tribe you receive continued support through mummy social dinners out, buggy walks and most recently we had a lovely afternoon tea.
You also receive our Serene Mummy Tribe membership card which gives you discounts to lots of amazing baby and mummy friendly businesses.
So why have we created this card?
I wanted to give you back something that will help you stayed connected with others, bring people together and to support you on your parenthood journey.
Below you will find a list of all the businesses offering you a discount when you show them your unique Serene Mummy Tribe membership card. This list will continue to grow, so always check back regularly to see what new businesses have been added.
Primrose Hair is offering you lovely mummies 10% off your first hair appointment. As I use them myself I can highly recommend. We talk alot about self-care in class so why not treat yourself to a lovely relaxing cut, wash and blow. You definitely deserve it! Contact: 07857210182
Kandy's Cakes – The lovely Katrina is offering the Serene Mummy Tribe 10% off your first cake order.
She provides a friendly and professional service, so no matter how big or small your event she will be able to cater for you. She is located in Bedford but can deliver to all surrounding areas.
All of her cakes can be made gluten, wheat, dairy or egg free if needed. Contact Us on 07748 678862 or email@example.com.
Capture The Light Photography is giving you 50% off your photo session – The very talented Emma over at https://capturethelightphoto.co.uk/ can book you in for your baby or toddler photo shoot.
Cast and Present Memories is offering 10% off your product – The lovely Sam will be able to help you over at https://www.castandpresentmemories.co.uk pop over and see her gorgeous work.
The Pavilion At The Park is giving you buy one hot drink, get a FREE refill. What sounds better then having a buggy walk around Bedford park, with a hot drink catching up with friends. To find Location and to view more details pop to http://pavilion.attheparkbedford.co.uk/
Baby College is letting you have your first class as a FREE trial, to find out what Tiffiny's classes are all about head over to https://www.babycollege.co.uk/bedford. You will need a unique discount code for this which I will give to you.
Inspire Performing Arts – The lovely Rosie is offering all new members a FREE 2 week trial in any dance class. Classes are suitable for ages 18 months upwards. For more information head over to the Inspire Performing Arts website. www.inspirepa.co.uk – Classes run in Kempston and Cotton End, Bedford, Bedfordshire.
Kerry Northey Photography – Kerry will be offering my mummy tribe members 10% off any photoshoot session, Kerry runs her sessions from her studio at home which is based in Kempston, Bedford. She also offers outdoor photoshoots. To find out more information and to view her gorgeous newborn images pop over to her website www.kerrynortheyphotography.co.uk
Tropic is giving you 10% off your products. The very knowledgeable Becky will be able to help you choose the right product for you, self care is very important, and I highly recommended these amazing products. Click on the following link http://www.tropicskincare.co.uk/shop/beckycoomber to view all products. You can also contact Becky at email@example.com. This discount can only be directly used with Becky.
Bedfordshire Fun are offering you a huge 20% off your bouncy castle hire, just by showing them your Serene Mummy Tribe card. The super experienced and friendly staff can help you with your booking and set up of your bouncy castle hire. Check out what else they have to offer here https://www.bedfordshirefun.co.uk/
The Beauty Cabin the lovely Mandy will be offering all you lovely mummies (& daddies if they wish) 10% off an eyebrow or eyelash treatment. I can highly recommend Mandy as I go to her myself, she puts such care in to each treatment and is a perfectionist, so you are sure to leave The Beauty Cabin filling fabulous! Head over to her Facebook page to see her amazing work.
The Embankment Pub (Bedford) are giving you a FREE hot drink when you have purchased a Breakfast with them. Breakfast is available 7am- 11:30am. A chance to catch up and go for a lovely stroll down the embankment river.
Otter & Moose are offering 10% off all items on their website for mummy tribe members.
Need a self care package for you or a friend? Otter & Moose are a Bedford based gift company who specialises in curated gift boxes full of locally sourced goodies.
Just enter the code Serene1 at checkout! Any questions just head over to https://www.otterandmoose.co.uk/ and the lovely Carrie will be able to help you find that perfect gift or of course treat yourself.
Beauty of Bedford are offering you amazing mummies 10% off all beauty treatments – The very lovely Seline & Maria will be able to help you with those self-care duties, from facials, manicures, pedicures or a pampering massage you name it these ladies have got it covered! Head over to www.beautyofbedford.co.uk to see all the fantastic treatments they have at their gorgeous salon and be prepared to be truly spoiled.


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Proven techniques for your unique business.
Your journey towards marketing success is unique, but the tools that will get you there have been proven time and time again.
Learn more about each of these inbound marketing services, and start putting together the kit you'll need to reach the top. And be sure to get in touch with us if you're wondering which options may be right for you. We've spent decades helping hundreds of companies like yours put these components to use for the marketing journey.
These are our inbound marketing services – and they're the tools we'll use to build the marketing campaign you've been looking for.
Choose the right tools for the journey.
– Don Moore, Vanquish Fencing
New North is not only thorough, but also easy to work with, and always willing to take the time to discuss concerns and respond to questions.
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Let us do a free 15-minute No-Pressure Marketing Conversation for you on how to transform your company's product or service in to a successful marketing strategy to grow your sales. Complete the form and we'll respond right away to schedule an appointment.
- Discuss your challenges with a marketing professional
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- Get a feel if New North is right for you


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"Subterranean Sizzle"
We are excited to share that our Laurel Woods Cellar project was featured in the September 2017 issue of Fine Homebuilding. Whether you're looking to refinish your basement, add a gym, or maybe even a spa, this project is a great starting point for all of your renovation ideas! Scroll down below for the full article.


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With mountain peaks as far as the eye can see, beautiful lakes, and pristine alpine air, Queenstown is simply a place of pure inspiration. Whether you have an appetite for adventure or are more at home tracking down a delicious meal, this cosmopolitan four Season Lake and alpine place provides the perfect mix of action and relaxation. Its population may be less than 20,000 but nearly 2 million visitors come to Queenstown each year to experience its spectacular scenery and diversity of experiences. With a huge range of activities easily accessible from skydiving, bungy jumping and jet boating to world class golf courses, walking and biking trails, spas, shopping, you can experience more here in a day than most do in a lifetime.
How to get here?
Getting to Queenstown is very easy as Queenstown International airport is well served by major airlines. Air New Zealand and Qantas fly direct from Sydney year round and extend this service to encompass Brisbane and Melbourne in winter. Domestically there are several connections each day from New Zealand's main centers like Auckland, Wellington and Christchurch. Access by road is a wonderful option even if its self drive or catch a Bus tour.
From September to November, there is spring time in Queenstown. The temperatures hover between 8 to 22 Celsius in daytime. Spring time here is loaded with lots of artistic, cultural and sporting events here. From December to February, the summer has temperatures hovering between 20 to 30 degree. Summer offers the ideal opportunity for international visitors to mingle with the buzzing throngs of New Zealanders making the very most of every blue sky minute. March to August is the winter's time. In winters, its not just about snow. Walking trails, superb shopping, day spas, over 150 restaurants are all on offer here.
Alpine Playgrounds
Coronet Peak
Coronet peak has the largest and most modern snow making facilities in New Zealand. With varied ski terrain and superb facilities, Coronet Peak is one of New Zealand's most popular ski resorts. Coronet Peak is located about a 25 minute drive from Queenstown. There are a lot of five star hotels, self contained motels, luxury lodges, stunning resorts and friendly bed and breakfast accommodation.
The Remarkables
The Remarkables are one of the most photographed mountain ranges in the world due to the spectacular jagged shapes and the steep rise above the shores of Lake Wakatipu. The mountain range is also famous for the Remarkable ski field.
Treble Cone
Treble Cone is the largest ski area in New Zealand's South Island and offers the longest vertical in Southern Lakes. Famous for its long groomed slopes, legendary and unrivalled views. It is a place you have to see to believe.
Cardrona Alpine Resort
Cardrona Resort is famous for a laid back atmosphere loved by snowboarders and families and also for on slope accommodation along with wide ranging terrain, serious half pipes and an excellent terrain park.
Invincible Snowfields
Invincible Snowfields Ski Area is a private ski resort near Glenorchy on the South Island of New Zealand. It offers skiers and snowboarders, the downhill terrain just 1 hour from Queenstown, The Snowfields area has an excellent back country feel and caters to advanced and expert skiers and snowboarders.
Southern Lakes Region
This stunning region really is like no other. The Southern Lakes scenery and culture has inspired Hollywood movie makers, poets, artists, authors, musicians and every sort of adventurer as well as more usual everyday people. There are some lake side resorts here like Lake Wanaka and Te Anau which share an adventurous spirit and natural splendor. Queenstown and Wanaka are separated by just one hour's drive over the Crown Range. The resort town of Te Anau is an ideal base for exploring the Fiordland National Park which is a World Heritage area.
There is a huge range of accommodation options built up during Queenstown's 100 years as a tourist resort that satisfies every type of traveler. There is a long range of 3, 4, 5 star hotels and exclusive luxury lodges, charming B&Bs, farm and home stay options which offer a taste of New Zealand hospitality. While motels or managed apartments are ideal for those who prefer independence or privacy. There are many Holiday parks and campgrounds having excellent facilities. You can get close to nature in Department of Conservation huts in mountain and bush areas.
The ultimate in taste sensations, there are more than 150 eateries to choose from in Queenstown excluding the winery restaurants between Lake Hayes and Gibbston valley. Here is a fusion of many nationalities, cultures and influences that cook up truly delicious menu options that suit every taste and budget.
Don't forget to try a mouth watering gourmet burger enjoyment by the lake side or the indulgence of a delectable menu in a discreetly hidden away intimate venue. In the warmer months, the streets buzz with al fresco diners basking in late sunsets, drinking locally crafted, award winning beers and wine and in winter, with hearty fare in front of roaring fireplaces.
Getting around the downtown area in Queenstown is best by foot as many shops are in pedestrian area or hidden away down narrow lanes. As you explore, breathtaking views are never more than a few paces away providing a constant aesthetic and emotional stimulus. Queenstown is arguably the best place in the world to buy traditional wool and sheep skin clothing and indigenous Pounamu (greenstone). Glenorchy here is the spot for funky possum skin clothing and home textiles.
Queenstown is truly committed to provide inspirational and rewarding holidays for visitors from all over the world. So, come and experience this beautiful city yourself.


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The ability to search the contents of emails, not just the Subject
It is a deal killer for business use to not be able to search the contents of emails Vs just subject titles. Combine that with the TERRIBLE conversation thread that will not open ALL messages at the same time and PM may be doing great engineering but poor client business development.
The ProtonMail Bridge supports this by allowing ProtonMail to work with any Desktop email client so full text search can be performed locally without compromising the end-to-end encryption.
35 comments
I'm heartbroken. I can't find my messages. I've spent a long time going through them reading them. I still love Protonmail, but man this feature is badly needed.
Gregory Schwedock commented
jchook commented
Client-side search of the last n emails should be sufficient, perhaps with a configurable "n". Most searches are for relatively recent email.
B commented
Can't search in the app?
I'm sure it's complicated stuff to implement, but you should get the whole damn team on solving this! Yesterday!
Any updates? search is a staple!
David commented
It sounds like Bridge should be a reasonable solution for the desktop. You should also add full text search features to your mobile apps! Smartphones are getting big and fast enough that it is perfectly feasible to store an index of all e-mail locally.
It's probably not impossible to do full text search for webmail to around the same level of security that protonmail can currently provide for webmail. You don't need FHE or anything crazy like that.
You would have to provide a read/write store to the client, and then use that to update (and use) an encrypted search index from the client. You might be able to do *some* level of traffic analysis on the user's searches by looking at overlaps between the byte ranges they read, but you already have access to lots of traffic data more sensitive than that.
But frankly if you can get desktop and mobile apps with FTS, it's probably good enough for me.
So what about mobile clients? As far as I understand this bridge must be installed on a client machine. Such setup will not be possible on IOS at least. Why not using tried and tested PGP and stuff that works with every single client on this planet?
Nicholas commented
"The upcoming ProtonMail Bridge will support this by allowing ProtonMail to work with any Desktop email client so full text search can be performed locally without compromising the end-to-end encryption."
And for those that will continue to use ProtonMail solely via the web client?
Eivind commented
You could have the client maintain a corpus over the entire sets of emails that gradually get added to and built. This corpus you could encrypt the same way as the emails and thereby provide search. I know this is not trivial to make good, and people being used to google levels of search, but I think this is at least worth a shot.
[Deleted User] commented
How can proton mail search in the subject, date, etc if the emails are encrypted? Is the subject, date and header in general not encrypted or is the search done in the client side? Can the client side hold and search let's say a million email headers if I have a million emails in my inbox?
The searching would have to be done client-side. PM doesn't have access to the content of your emails, so they can't do searches over the content.
Fully homomorphic encryption isn't anywhere near efficient enough for practical application yet, so there is no way PM could provide you this service on their end.
However, if you were willing to download and locally store all of your emails on your own machine, then the searching could be done on the client side.
Anonylyzer commented
This would be quite helpful.
Tim Underwood commented
Would be a great feature, but encryption > search every time.
Mike D commented
The longer I've been using protonmail the more the searching is upsetting.
I can't find anything, because searching is so limited.
Hart commented
Would like this and don't see any way it could work. I suppose a VM could be created behind a firewall, all my mail decrypted, the search completed, and everything but the matching mail identifiers purged? I like the encryption more than the search.
Further thought.... there are usually 3 of us that are logged into one gmail account through the day from 3 different machines. Not sure how that would work with downloading a local copy of email - maybe configuring one download file/folder and having access from multiple computers into that one account?? Lots to think about.
As the "tech guy" at a small law firm that is looking to move from gmail to something secure, I just noticed this thread and thought, "of course". Can't assume! Searching content is a necessity. from my perspective, the encryption on email should apply to everything outside of my computer. Once the email is in my computer, I am not so concerned with encryption. I'd be happy to download the mail (i.e. always downloaded and updated in real-time) - either all of it or a subset (perhaps date delimited) - and then have it searchable by the local client.
Dee commented
Searchable is key for me to use PM for work as my chains get get long and subjects don't always get updated. I understand the need to download or place into ram just to search but if PM offered an encryption key for you, the user and you did set a search criteria they could filter emails to your PM(drive) to search as cache. That gets purged after closing the search window or logging out.
Raymond commented
The best way I can think of for doing this is to download the last x number of emails, decrypt them, and search through that. Then have a link to "keep searching" or something which would download another chunk and search them. Obviously make this work with the advanced search so people can limit it as much as they know to start with.
Alfonso commented
It's a miracle that you can search by subject given they should be encrypted. What does not make sense is to search by content... because they are encrypted!
You simply can't search what you can't read! Unless they cache your encripted emails in your browser to search on them. But it is not reasonable to download all your inbox to search on it whenever you want to search...
I find this feature not reasonable given this :\
And that is why the subjects are VERY important.
I hope I am wrong.


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10 of the Most Beautiful Bridges in Canada
Travel Canada
Let's face it: bridges are an amazing way to flex your photography muscles. From quaint covered bridges to engineering marvels, these bridges—captured by Our Canada readers—are some of our favourites.
Photo: Brenda Newman
The City of Bridges
There couldn't be a more appropriate nickname for Saskatoon than "The City of Bridges." After all, the prairie destination is home to 80 bridges, overpasses and pedestrian crossings—each one pivotal to the city's formation and growth.
Find out why Saskatoon is Canada's next great culinary destination!
Photo: Susan Nicks
Golden Ears Bridge
Opened in 2009, the six-lane Golden Ears Bridge in Vancouver spans the Fraser River, connecting Langley on the south side with Maple Ridge on the north side. Photographer Susan Nicks took this shot while boating under the impressive structure!
Don't miss these 15 incredible photos of big things across Canada.
Photo: Cindy Bartoli
Over Welland Canal
Cindy Bartoli of Peterborough, Ont., writes: "The clouds, lighting, and fall colours came together for this shot of a train bridge over the Welland Canal in my home province."


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Project Description
An Evening with Brian Rose and Former Players
On Friday 24th May 2019, ConciergeUK put on an event that will never be repeated. This event saw Brian Rose, Sir Ian Botham, Vic Marks, Dennis Breakwell, and Andy Caddick come together to celebrate the 40th anniversary of the Gillette Cup Final. This particular event turned out to be even more poignant as the very next day Somerset took home the Royal London Cup beating Hampshire at Lords!
The evening kicked off with a fish & chip supper followed by a Q&A session with Brian Rose, Vic Marks, Dennis Breakwell and Sir Ian Botham. The evening was then rounded off with an auction whereby an array of cricket memorabilia was up for grabs.
Having known Brian Rose for a number of years, it was about time that we pay a tribute to him and his Somerset County Cricket Club career. With a sold out room of over 220 cricketing followers, what better place to invite the former players. A special mention to Sir Ian Botham for making the long journey south, just to support Brian on his evening. Thank you to our sponsors Hire365 for sponsoring the event. Special mention to Graham (Maz) Masarik for your help and of course our CUK Team, another superb event organised by ConciergeUK.


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Free Credit Reports, Scores and Credit Services.
In the world of credit reporting and credit scoring there are a lot of free things available.
You Won't Need Your Credit Card For Any Of The Following!
AnnualCreditReport.com – This website was set up pursuant to a 2003 amendment to the Fair Credit Reporting Act. It is maintained by the credit reporting agencies, Equifax, Experian and TransUnion. The site's purpose is to act as the central source where U.S citizens can request a free copy of their credit reports once every 12 months.
CreditSesame.com – This is a for profit website that gives away a free credit score based on Experian data. The score that is given away is called the Experian National Risk Score, and it ranges from 360 to 840 and it is a very good approximation of your FICO score (at least it always has been for me). The user experience is very clean and easy to understand.
www.optoutprescreen.com – This is another legislatively mandated website that the credit reporting agencies have to make available to consumers. There are no free credit scores or credit reports on this site. Here you can have your name excluded from any prequalified mailing lists sold by the credit bureaus to credit card issuers. You can "opt out" for a few years or permanently. I've been opted out for years and I don't get credit card offers in the mail any longer.
www.CreditKarma.com – This is a for profit website that gives away a free credit score based on TransUnion data. The score that is given away is your VantageScore credit score. The VantageScore credit score is the 2nd most commonly used credit bureau based scoring system. We're all focused on our FICO scores, and rightfully so, but with some 1,300 lenders using the VantageScore credit score (according to Experian) we need to start paying attention to it as well.
www.Credit.com – This is a for profit website that gives away a free credit score based on Experian data. The score that is given away is your VantageScore credit score, but based on Experian data rather than TransUnion data like the one given away by CreditKarma. The scaling of this particular version of the VantageScore is 300 to 850, which is the same as FICO's 300 to 850 score range.
LexisNexis – I bet you didn't know that LexisNexis is considered a consumer reporting agency. They maintain the "CLUE" database, which stands for Comprehensive Loss Underwriting Exchange. This database is like a credit bureau but only for insurance companies. If you've filed an auto or homeowner's claim in the past 7 years then you probably have a CLUE Report and those reports are sold to insurance companies to help them determine your premiums. You can get free copies of those reports at their website.


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Industrial Stocks Charge to Record Highs
Data released on Friday reveals gross domestic product grew at a much faster-than-expected pace of 4.1% last quarter. This rapid rate of growth is giving a big boost to economically sensitive industrial stocks. Of the 64 industrial names in the S&P 500, 21, or one-third, are on track to close out the week in record territory.
Continue Reading Below
Industrial Stocks Charge to Record Highs


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Similar Content
By Schattie4585
Hello my comrades. This project was dead for a long time. I didn't do anything and something went wrong and I wasn't at all happy with the results. Because of this, I deleted everything and started all over again. From now on I try a lot more with the map and hope that it will be well received by you. This map will cover the history of the Far East. The focus will be primarily on the two countries China and Mongolia. Many other countries will also appear. These are not so much in focus, but I try to do it there too. I put the most effort into China and Mongolia. It won't all be perfect, but I'll try it.
The following countries occur: China, Mongolia, Afghanistan, Pakistan, India, Kyrgyzstan, Tajikistan, Uzbekistan, Kazakhstan, Russia, Nepal, Bhutan, Bangladesh, Myanmar, Thailand, Laos, Vietnam, Philippines, Japan, Taiwan, North Korea and South Korea. Progress = 25%
Other advances: Taiwan:
By Sr. _Mario_Vargas
Saludos a todos los que se asomaron por aquí a ver mi trabajo. en esta ocasión les traigo un escenario sobre los Estados, regiones, provincias y departamentos de los países de américa, Desde Canadá hasta chile. Espero que lo disfruten.
En este escenario podrás encontrar:
Las regiones de Chile - Las provincias de Argentina. Ecuador y Cuba - Los departamentos Colombianos, Peruanos, Bolivianos y Paraguayos - y - Los estados de Venezuela
Todo esto, bajo los limites que ofrece el juego con sus propias provincias originales.
Por el momento centro américa no está incluida, debido a que lanzare mi escenario antes de finalizarlo, para averiguar cómo será la recepción de la comunidad.
States of America.rar
By Alanva36
Hello there!
My Plan Was To make a Fresh Modern Day that will be Part Of More Than 1 Scenario.
Modern Day Scenario Contains:
New Fresh Map 307 Countries[Including New] Custom Ideologies[WIP] Events[WIP] Alliances[African Axis,African Comitern] Fun And More! Download:
This Is How It Looks:
Our picks
DOWNLOAD NOW | Conqueror's II v1.1
Kerems2434 posted a topic in Mods,
Bringing turn count to 1 to avoid the permanent 0 relations glitch. Plus new way to switch countries.
Map Editor 2.0
Reich posted a topic in Download,Improved version of the map editor, which differs from the usual one in that this version does not need to constantly restart the editor and manually rename the province files. This innovation will significantly reduce the time spent on creating a map and save your nerves.
- 31 replies
Age of Civilizations 2 | Addon 2.0 | Addon+ | Update 01.12.19Addon 2.0 is our new global modification, designed to revise the idea of the original, and significantly expand its potential, due to the excellent implementation.
- 706 replies
Picked Byleonsojko627391,
Age of Elder Scrolls | FROZEN
Suzema posted a topic in Mods,Age of Elder Scrolls - is a mod that takes you to the universe of Elder Scrolls, to the planet Nirn. There will be:
- A big map of Nirn;
- Large count of elaborated scenarios;
- New ideologies;
- New diseases;
- Music from TES games;
- Remaded ages;
- Various wonders;
This mod will be developed for a long time, during the development something new will be added.
We are in VK - https://vk.com/ageofelderscrolls
- 159 replies
Picked ByMr.Snake,


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Location & Currency
Arrow is offering an Italian made exhaust for your KTM 690 Duke. The X-Kone exhaust is known for superb sound and performance, as well as noticeable weight reduction.
Available in a Titanium finish or Stainless Steel Nichrom finish. Both silencer finish options offer a Carbon Fiber end cap. Removable dB killer is included.
Note: This silencer will only fit the stock headers if you add the Arrow link pipe (71486MI). This is the "Slip On" option.
Note: Arrow offers racing headers/collectors to create a full system (71487MI). This is the "Full System" option.
Arrow Part # Titanium X-Cone (71799XK)Nichrom X-Cone (71799XKI)
Options:Arrow Link Pipe for installing to stock headers as a slipon only (71487MI)Arrow Racing Headers (Add to create a Full System) (71487MI)
© 2004 - 2020 Motovation Accessories. All rights reserved.


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Lemon Chamomile Scone (Black Tea)
We have run out of stock for this item.
A pocket full of sunshine, that's exactly what Lemon Chamomile Scone tea is! For those who know me, you'll know that I've never been a fan of chamomile, ever. BUT! Knowing that others enjoy chamomile and having been inspired by an afternoon tea menu item I saw on the interwebs, I wanted to give this a whirl and - are you ready for this? - this just might be my favourite out of the 8 teas! Can you believe it??
So light, so bright, so lemony fresh and sweet! Lemon and chamomile mingle with turmeric, vanilla, and maple for a naturally sweet black tea infusion. Sunshine in a teacup!
Certified organic ingredients: Black Tea, Lemon Peel, Vanilla, Egyptian Chamomile, Turmeric, Canadian Maple, Palm Sugar
Handcrafted in Toronto, Canada.
Steeping instructions: 2 tea spoons at 212F for 4-6 mins


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Welcome on the home page of B&K Ltd. When reading our pages you can get information of the story, activity of our company, you can see what our goals are, what our products and services are. I hope that you as our present or future business partner will be convinced during your visit on these pages that B&K Ltd. wants to be and to remain your correct business partner, ready for cooperation on the basis of mutual advantages.
Our company was founded in 1991 with the aim of providing reliable and high level accounting and councelling services for newly founded companies and private enterprises and with the other aim of producing and distributing top quality sanitary and hygienic products for the building and the food industries. Bythe time the councelling unit of the company has left B&K and continued its operation separetly as EcoFact Ltd.
Product range of our Hygienic branch has been developing in such a way that customers can buy everything that is necessary for public water-blocks, for the hygiene of food industry, catering and health care. Since the beginning it has been very important for us beyond sales to support installation, build-in and use of our products, giving special advice and service activity to the customers. We consider one of our main tasks to have got adequate good level of organization, technology, that is why we have got the quality certificate ISO 9001 since 1996. Taking care of our procedures we develop our organization, technology, products and train our colleagues. Knowingly we develop our connections of suppliers and cooperations. All this is done so that we can fulfil expectations of our customers as much as possible.
Last but not least I must mention my colleagues, also those ones who are not members of our present staff, yet. They helped and help now my everyday work with their ideas, advice and hard work. With them we managed to achive an organization, being able to be happy for success and to amend defaults/mistakes. I am proud of my colleagues ability for getting innovative that helped us in the past to go through several heavy problems.
We want to be successful as well as want you to use our products and services with satisfaction.
Thank you for your kind attention.
Yours sincerely
Mr. György Kugel
managing director


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This one-of-a-kind boutique hotel on Route 62 does justice to its National Monument status.
Imagine driving through a quaint town and stumbling on an unexpected gem. Among the quaint country offerings that are usually found in lesser-visited Robertson, this hotel easily fills the gap for something bold and daring. There are just 10 suites in this tiny hotel, and the eclectic interiors and standout style have certainly made an impression on its visitors – the reviews are glowing. The on-site Small Restaurant features an equally petite menu, with food that rivals the quality you'd find in popular Franschhoek and Stellenbosch. Two small pools can be found by the garden and The Wellness Room, where guests can enjoy massages and beauty treatments (at extra cost). Service is passionate and thoughtful additions like a complimentary minibar in your suite proves that it's the little things that make all the difference.
There's an impressive variety of Suites; three are housed in the Manor House, a building originally built in 1909 with National Monument status; four Poolside Suites have direct access to the hotel's small pool; and three Stable Suites overlook a second pool and features a loft-conversion Honeymoon Suite. Each of the Suites is refreshingly original and features underfloor heating, tea and coffee making facilities and a complimentary minibar including local wine and beers.
Key information
In central Robertson on South Africa's famous wine route, Route 62
Good to know
Accommodation information
10 individually designed rooms and suites
Restaurant, bar
*Denotes local charge


text: Calamity 66 Posted July 3, 2017 10 hours ago, BengFisher said: "because it will be easier for you to craft things now" <=== easier will make prices down broh :) Meaning no offense bro It doesn't necessarily mean the price would go down in an instant. @Orange had said that the crafting difficulty will remain the same, the materials needed are more widely dispersed, so you have to kill some of the monsters to get the materials. I feel it would bring much more fun compare to you destructing equipments from NPC/monster drops. Quote Share this post Link to post Share on other sites


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The Importance of Being ... Enforced
When you are being watched, most of us pay a little (or a lot) closer attention to what we're doing. It's human nature to be mindful and act accordingly.
When you're a marketing organization and being watched is a matter of law, the risks of non-compliance can weigh very heavy when a firm runs afoul and is caught. Few businesses can well afford litigation, fines and bad publicity, plus potential years of consent agreements with all the documentation that may be required. Brand damage.
Now let's turn to self-regulation.
When you're a marketing organization and being watched is matter of ethics, or of best practices, the risks of non-compliance may be either heavy or light — depending on the compliance question, its marketplace implications and how cooperative the organization is to conform to industry expectations.
Self-regulation, more accurately peer regulation, is usually more preferable than direct government regulation.
For one, in data-driven marketing, innovation is a constant. Disruption is ever-present. Technology keeps changing. How can government regulation even keep up? It rarely does. That's where self-regulation provides American business a great advantage: rules of the road get set by principle, and the market adapts to those principles.
Then, there's enforcement of those principles. For example, I work for the Digital Advertising Alliance — a self-regulatory program based on principles for interest-based advertising and multi-site data collection for the desktop world that have been adapted for mobile and cross-device environments. I'm also a member of DMA [Direct Marketing Association], which serves as one accountability partner of DAA (the other being the Council of Better Business Bureaus Advertising Self-Regulatory Commission). These two organizations enforce DAA Principles, each in their own way. However, they are independent from DAA: Those of us who work at DAA are not privy to DMA and ASRC self-regulatory enforcement investigations, until those proceedings are made public.


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Two comics in one week! Wow! It must be a holiday!
Lots of cute talking creatures, one girl, no plot.
Two comics in one week! Wow! It must be a holiday!
Top o' the evening to you, too.
Ah, a relaxing interlude.
Hey! Turns out Krita can run on my laptop, and because that has a VGA out jack, I could do this on a proper screen instead of inflaming my flaming neck and that's another comic for another time.
So yeah, cardinal pick-up lines. You're welcome.
Someday I'll get the relaxing thing I enjoyed doing back and we won't have to endure these previews. Meanwhile, have a scrawl of the exciting next episode, which won't look like this at all once it's completed.
The hard drive in the computer capable of running Krita, the drawing app, is no more. With it went the comic I really wish I had finished. But no, I was starting a new phase of Not Stressing and walking away when I had to.
That sort of behavior is not what brought you all this comic for 15+ years.
I've seen other comics go this way, a drive failure, LIFE EVENTS, and I really don't want that to happen because this comic is literally my life and I have a pile of ideas I want to draw. I even wanted to get into animations, and someday maybe I will, but for now I'm going to keep it as simple as possible so I can just get cute cat and dog comics in your eyeballs instead of just moping about how I really really should have moved that one file over to the old computer even though it wasn't finished yet.
Do you believe in the power of Mercury retrograde to disrupt things?
I was going to make a joke on Wednesday that I was giving up my comic for Lent, but as it turns out the computer that runs Krita and has the artwork for the next comic gave up on working properly, so until I get it working again through fancy key combos or just removing the hard drive and finding the comic, I owe you a movie. I would have had it finished in another hour.
I may be going ahead with the March adventures as ol' pencil-and-Paint-Shop-Pro comics I can still manage on my old duffer PC. I don't know yet. I don't really know anything right now.
Fortunately, we have top men working on things.
I guess a week isn't enough time to put a comic together, even one that's way less involved than what I had originally planned. I have 5 valid reasons for not having this ready, and in the olden days I would make comics about that but we see how that's been going. The next exciting adventure be finished by the end of the week, I promise.
And so I did. *purr*
Movie Month 2020 begins with the cutest spoof of the most disturbing movie I've seen involving gulls since The Birds!
(Seriously, don't watch The Lighthouse if you like birds. Just look at this and go have a drink.)
Prints and more are now available at Society 6! Click here to buy a print of this comic!
He can snuggle with me any time. ROWR!
Whaaaaat, a Friday comic?! Internet Puppy Pals are having a fundraiser! It's everyone's worst nightmare, my bestie and her mom are being kicked off the land where they've lived for years with the adorable and sweet dogs they've rescued, and they can't take the dogs with them. My friend wants to make sure her nine dogs survive this bullshit and she's raising money to get them into a no-kill shelter.
Even if you're broke, you can help by sharing the link. Please click through to read the whole story and thanks!
Man, I gotta 3D print some new bodies for the whole lot of us. Anyone got a 3D printer with body cartridges or however that works?
You come see us any ol' time.


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Loyalty, passion and care… This is Balu Pet Sitting Services.
My name is Caterina and I'm a HUGE animal lover!
I have been volunteering with animal rescues and also have attended many dog training and agility classes with my beautiful rescue dog Luke.
I am currently attending a dog psychology and training course at Career Academy.
I have decided to take it one step forward by starting Balu Pet Sitting Services with the help of my husband.
For your peace of mind we provide Police Clearance and we operate safely with Public and Product Liability Insurance.
Contact us for any enquiry. FREE meet and greet!


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The flashcards below were created by user
FreezingBlue Flashcards
Physical Activity
any bodily movement produced by the conraction of skeletal muscles that increases energy expenditure above a basal level and enhances health.
Aerobic Training
Training that improves the efficiency of the aerobic energy-producing systems and that can improve cardiorespiratory endurance.
a skill-related component of physical fitness that relates to the abiity to rapidly change the position of the entire body in space, with speed and accuracy.
Anaerobic Training
Training that improves the efficiency of the anaerobic energy-producing systems and that can increase muscular strength and tolerance for acid-base imbalances during high-intensity effort.
a skill-related component of physical fitness that relates to the maintenance of equilibrium while either stationary or in motion.
Body Composition
a health-related component of physical fitness that relates to the relative amounts of muscle, fat bone, and other vital body tissues.
Methods (indirect and direct) used to calculate the rate and quantity of energy expenditure when the body is at rest and during physical exertion.
Direct Calorimetry
a method that gauges the body's rate and quantity of energy production by direct measurement of the body's heat production. Uses a calorimeter.
Indirect Calorimetry
a method of estimating energy expenditure by measuring respiratory gases; given that the amount of O
and CO
exchanged in the lungs normally equals that used and released by body tissues, caloric expenditure can be meausured by CO
production and O
Cardiorespiratory Endurance (cardiorespiratory fitness)
a health-related component of physical fitness that relates to the ability of the circulatory and respiratory systems to supply oxygen during sustained physical activity.
a skill-related component of physical fitness that relates to the ability to use the senses, such as sight and hearing, together with body parts, in performing motor tasks smoothly and accurately.
changes the body undergoes in response to a reduction or cessation of regular physical training.
Endurance Training and Endurance Activities
repetitive aerobic use of large muscles (e.g., walking, bicycling, swimming).
Exercise (exercise training)
planned, structured, and repetitive bodily movement done to improve or maintain one or more components of physical fitness.
a health-related component of physical fitness that relates to the range of motion available at a joint.
Kilocalorie (kcal)
a measurement of energy: 1 kilocalorie = 1 calorie = 4,184 joules = 4.184 kilojoules.
Kilojoule (kjoule or kj)
a measurement of energy: 4.184 kilojoules = 4,184 joules = 1 calorie = 1 kilocalorie.
Maximal Heart Rate (HR
the highest heart rate value attainable during an all-out effort to the point of exhaustion.
Maximal Heart Rate Reserve
the difference between maximal heart rate and resting heart rate.
Maximal Oxygen Uptake (VO
the maximal capacity for oxygen consumption by the body during maximal exertion; also known as aerobic power, maximal oxygen consumption, and cardiorespiratory endurance capacity.
Metabolic Equivalent of Task (MET)
a unity used to estimate the metabolic cost (oxygen consumption) of physical activity, 1 MET equals the resting metabolic rate of approximately 3.5 ml O
per kilogram of body weight per minute.
Muscular Endurance
the ability of the muscle to continue to perform without fatigue.
Physical Activity
bodily movement that is produced by the contraction of skeletal muscle and that substantially increases energy expenditure.
Physical Fitness
a set of attributes that people have or achieve, which relates to the ability to perform physical activity. The components fall into two categories, health related and skill related.
a skill-related component of physical fitness that relates to the rate at which one can perform work. (strength over time)
Rating of Perceived Exertion (RPE)
a person's subjective assessment of how hard he or she is working; the Borg scale is a numerical scale for rating perceived exertion.
Reaction Time
a skill-related component of physical fitness that relates to the time elapsed between a stimulus and the beginning of the reaction to it.
Resistance Training
training designed to increase strength, power and muscle endurance.
Resting Heart Rate
the heart rate at rest, averaging 60 to 80 beats per minute.
recovery of conditioning after a period of inactivity.
a skill-related component of physical fitness relating to the ability to perform a movement within a short period of time.
the ability of the muscle to exert force.
Training Heart Rate (THR)
a heart rate goal established by using the heart rate equivalent to a selected training level (percentage of VO
). For example, if a training level of 75% VO
is desired, the VO
at 75% is determined and the heart rate corresponding to this VO
is selected as the THR.
Skill-Related Fitness Components
1. Agility
2. Balance
3. Coordination
4. Speed
5. Power
6. Reaction Time
Health-Related Fitness Components
1. Cardiorespiratory Endurance
2. Body Composition
3. Musculoskeletal Fitness
a. flexibility
b. muscular strength
c. muscular endurance
Based on the information of this chapter, which activity listed scores highest in the development of all five of the measurable elements of health-related physical fitness?
A) Running
B) Baseball
C) Badminton
D) Rowing
E) Bowling
D) Rowing
(this multiple choice question has been scrambled)
_____ is physical activity that is planned for purposes of improving health.
A) Work
B) Exercise
C) Aerobics
D) Physical Fitness
B) Exercise
(this multiple choice question has been scrambled)
Musculoskeletal fitness has three components, including flexibility, muscular strength, and _____.
A) cardiovascular endurance
B) speed
C) agility
D) coordination
E) muscular endurance
E) muscular endurance
(this multiple choice question has been scrambled)
_____ has been defined as any bodily movement produced by skeletal muscles that results in energy expenditure.
A) Power
B) Physical Activity
C) Muscular endurance
D) Body Composition
E) Flexibility
B) Physical Activity
(this multiple choice question has been scrambled)
Card Set
Exercise Testing and Prescription Ch1
Show Answers


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How to Recruit Volunteers by Appealing to the Emotions
Now, more than ever, our messages occupy a crowded landscape, and recruitment of volunteers is more difficult. Even if your volunteer/potential volunteer has opted into your communication, you'll still be competing with all the other information they are interested in receiving via email, text, social, direct mail, etc.
How do you get your volunteer recruitment ads or emails to cut through all that noise?
Sometimes, in an effort to get as much information out as possible, we jam tons of topics into one message. Or, we shout down the audience with bold proclamations and requests.
If we remember we're talking to a real person with real challenges and a real heart for your mission, we can start to see why this kind of chaotic, desperate communication rarely gets the desired results.
Do you like 3-page emails? Do you enjoy being guilted or shouted at on Facebook? I'm going to guess the answer is no.
On the flip side, what catches your attention? What stops your social media scroll? What kind of ads do you honestly read?
A good portion of what will get your attention is exactly the same for nearly every human being.
We're inundated with information and since we cannot process it all, we involuntarily rely upon emotion to tell us what's important and what's not. It's true for you and it's true for your potential volunteers. How? Because our human brains react based on cues.
The primitive human brain has six main triggers responsible for that involuntary attention grab we all experience. Four are instincts, and two are sentiments. When you harness both instinct and sentiment together, you'll find recruitment of volunteers becomes like second nature. And, responding to your recruitment ads will feel like second nature for potential volunteers.
Recruitment of Volunteers using Instinct
An instinct is a fixed, unconscious, (often innate) pattern of behavior. When a child is frightened, they cling to their parent. When someone is close behind you on a dark street at night, your instinct is to run. Instincts are usually present to ensure protection, so capitalizing on them in recruitment of volunteers can subconsciously make potential volunteers feel safe.
If people feel comfortable at the very first touchpoint of your nonprofit, they'll be much more likely to click that apply button. Here are the four main instinctual triggers and how to use them in recruitment of volunteers.
Our primitive brains are completely self-centered. Even though volunteers may join us for different reasons, their brains respond to "what's in it for me."
Ways to Use this Instinct in Recruitment
- Explain direct rewards of volunteering with your nonprofit.
- In email communications use their first name where appropriate.
- Phrase blog posts and ads like you are directly talking to one person.
- Use the word "you" in all communications.
Clear Contrast
Our primitive brains are always looking for things that clearly stand out as different from the norm. We used to use this to help instinctively identify danger. Now our brains can pinpoint when something is worth our attention.
Ways to Use this Instinct in Recruitment
- Clearly illustrate which text is most important by using a well-defined "large, medium, and small" hierarchy.
- Use all caps sparingly for very important info.
- Don't cram too much info. Let the readers eye rest by using plenty of white space.
- Use contrasting colors for calls-to-action and buttons.
Quick Input
The primitive brain processes information quickly and makes decisions based on what it finds. Dense, difficult to understand content prompts the brain to move on to something more digestible. This doesn't mean you should avoid long content. You just need to focus on readability.
Ways to Use this Instinct in Recruitment
- In ads, put the most compelling info at the very top. This isn't the place for suspense or legalese.
- Break up long, involved text into short paragraphs.
- Use numbered or bulleted lists to display information.
- Keep sections under 300 words.
- Use plenty of transition words like "and," "because," "then," etc.
- Use concrete ideas and avoid jargon
Beginning & Ending
The primitive brain focuses on the beginning and end of things. When scanning for information, it looks for key pieces, which are often found in the before and after.
Ways to Use this Instinct in Recruitment
- Start or end sentences with catchy phrases or words or the ad's main idea.
- Begin and end webpages with catchy images or headlines
- Break up overly long or run-on sentences.
Recruitment of Volunteers using Sentiment
Sentiment: exaggerated and self-indulgent feelings of tenderness or nostalgia.
The keyword here is "exaggerated." Media today is highly exaggerated politically, socially, emotionally… you name it. While you should certainly accurately portray your nonprofit, you can dip into what makes people react sentimentally by appealing to emotions.
Visual Stimuli
When we say humans are visual creatures, it's true. The optic nerve is forty times faster than the auditory nerve, which means visual inputs hit our brain faster. Consequently, we make decisions largely because of visual input.
Ways to Use this Sentiment in Recruitment
- Replace the stock photos
- Find a current volunteer or staff member with some photography skills, rent a professional camera if you don't have one, and have them spend a couple of days taking compelling, professional photos of your nonprofit. There is a huge unconscious difference between looking at good photos and low-resolution cell-phone shots.
- Use these photos on landing pages, in social media posts, in emails, and in print materials.
- Create a short, compelling intro video and put it on your homepage
- Utilize social media stories – these give people exclusive looks behind the scenes
- Try Facebook or Instagram Live – these let people connect with you how you really are
Emotional Appeal
Emotions make memories, events, and stories stick in the brain. Connecting to emotions makes a message more likely to catch attention and keep it. If you need inspiration, take a look at Instagram's self-titled account. All they do is tell emotionally-charged stories coupled with fantastic imagery.
Ways to Use this Sentiment in Recruitment
- Do a blog series on why current volunteers love serving with your nonprofit.
- Research and write transformational service beneficiary stories.
- Share before & after photos.
- Write emotional words in your marketing efforts.
- Use testimonials on your homepage and in advertisements.
Use the Primitive Brain, Don't Overload It
When using these triggers in your recruitment of volunteers, aim for simplicity. As you can tell from this list, the primitive brain is not triggered by complexity.
The goal is to get more eyeballs on your volunteer recruitment ad, so playing to the primitive brain will help drive that goal. Not every set of eyeballs will sign up to be a volunteer, but you can increase the opportunities just by positioning your ad for easier consumption.
Free [eCourse] Better Volunteer Recruitment
in 6 Easy Steps
Learn how to cut through the clutter and connect with enthusiastic supporters.


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I just finished watching a great video from Jim Lamb on Channel 9 covering some of the new features for Team Foundation Build 2010. The video is about 35 minutes long and is well worth the watch. Here's a quick synopsis of what's covered in the video:
- Team Foundation Build 2010 will support Windows Workflow 4.0. This feature alone would make a worthy upgrade to Team Foundation Build. The new Workflow UI being designed for the .NET Framework 4.0 will be included in the build type editor within VS 2010 providing a fantastic user experience for modifying build types (can you say "XML – not for me, thank you" :-). There will be several Team Foundation Build-related Workflow Activities included out of the box with VS 2010 and I would imagine several 3rd party/open source activities will appear on the scene shortly after its release.
- "Gated" check-ins will be supported. This feature, when turned on, will ensure that a given build type successfully runs before any artifacts are checked into version control. This will be a great enhancement for teams making use of continuous integration within Team Foundation Server.
- "Private/Buddy" check-ins will be supported. This feature is very much like "Gated" check-ins except that the check-in, and resulting build, are treated as a separate, private build associated only with the user who initiated the build. You can even set distinct retention policies for "Private" builds.
- Support for Symbol Server Integration. With the integration of Symbol Server into Team Foundation Build, the debugger within Visual Studio will know how to navigate to the correct source code within TFS Version Control.
- Build Controllers. You will have the ability to configure "pools" of build agents which can then be associated with a build type. The build server can then utilize the least active build agent when starting a new build.
- Build Agent Tags. You will be able to associate tags with build agents. For example, you may tag a build server as "SQL Server 2008", meaning that SQL Server 2008 has been installed on that server. Another build agent may be tagged with "MOSS 2007", etc.
- "All Inclusive" Build Agent. There is a desire to have the build services include support for MSTest and DBPro without having to install the Test or DBPro SKUs. This will be a great convenience and something that I believe that should have been included from the first version.
- Log Enhancements. The Build Log has been improved tremendously and is much easier to read and navigate. You can now, for example, click a link on an error in the build log and be taken to the exact location within source code where the error occurred.
- Build Deletion Control. When deleting build types, you will now have the ability to be more specific as to what gets deleted. For example, you can choose one or more of the following (all are selected by default): Details, Drop, Test Results, Label, Symbols, or Build. This can be done manually and/or specified within the retention policy settings.
The video goes into a little more detail about each of the above items as well as a few others that I haven't mentioned. It is really nice to see that Team Foundation Build is getting some attention. I think the current product is good but there is a lot of room for improvement and it appears that is the direction it's heading.


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A build-up of ear wax in the ear canal is a common problem that can cause pain as well as a range of health problems. You can easily manage the condition. But if left untreated, ear wax build-up can adversely affect your health and quality of life. So it's important to forego home remedies and seek professional ear wax treatment as soon as possible.
At Hearing Expert in Wirral, our same day ear wax removal service is quick, painless and effective. Our audiologists and fully qualified medical professionals safely remove excess earwax via instrumentation, syringing and microsuction.
At your appointment, we'll ask you to fill in an ear health questionnaire. We then follow this with a painless video otoscopy to see what's going on inside your ear. This procedure lets us know if too much ear wax (also known as cerumen) is the issue. It also provides us with more information so we can accurately determine our next steps.
Your ear canal is delicate. So if you're struggling with excessive ear wax, don't poke inside your ear to try to remove it, as this can cause damage to the inner ear. Many people use cotton swabs to "clean" excess ear wax from their ears. However, this is more likely to cause earwax blockage and other issues that can lead to infection. Therefore, it is essential to see an ear wax removal specialist before any complications arise.
At Hearing Expert, our highly skilled team know what is required to provide the right treatment for you. There are three different ways to safely remove ear wax, which we explain below:
In minor cases of soft wax or where excessive ear wax is close to the opening of your ear canal, we can use specially designed tools to remove ear wax manually. Our experienced staff will gently tease the wax out of the ear canal. For cases of impacted or hard, dry ear wax, we may use this technique initially, before moving onto ear syringing or ear microsuction.
Alternatively, you may need your ear syringing, a procedure also known as ear irrigation. Ear syringing is painless and uses an electric pump to push warm water into your ear to wash the ear wax out. This method is best for removing wet or very soft wax that has collected on the eardrum.
Microsuction of ear wax removal is widely considered to be the quickest and safest method of ear wax removal — even hard or impacted wax. The ear wax is vacuumed from the ear using a microscope and a small medically approved suction device, ensuring a comfortable patient experience.
View our blog post on How To Remove Ear Wax? for more information.
We sometimes use a combination of all three techniques to do the best possible job. Once the ear wax removal procedure is complete, we'll provide you with professional advice on how to care for your ears in the future.
At Hearing Expert, we take the time to understand exactly what you're experiencing, so we can offer the ideal solution.
For pricing details or to book an appointment, visit our Ear Wax Removal Cost page. Book your ear wax removal session, hearing test or hearing aids consultation in Wirral today
Hearing Expert is the preferred clinic for earwax buildup removal because we pride ourselves on adding a personal touch to every appointment.
We know how important hearing is to the quality of your life, which is why we take the time to understand exactly what you're experiencing so that we can offer the ideal solution. Our small team is like family, and we strive to do whatever we can to assist every patient in Wirral with the hearing problems they may be experiencing.
As a Hearing Expert patient suffering with hearing loss, you can expect to feel more like yourself in no time at all.
Last minute appointment. Excellent service. Professional, efficient, trustworthy, courteous, reassuring all together amazing experience. Highly recommend. Thank you.
-Maria Polachowska
Great service – Ian was friendly, talked me through the process and offered to show my images inside my ear both before and after the wax removal process. It was quick, painless and my hearing was instantly improved. Highly recommended.
-Andrew Sweeney more
I have no hesitation in recommending Ian for anyone with hearing difficulties. I've been with Ian for several years now and he has never been anything less than thorough, professional and helpful.
-Brian Johnson


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Smart shoppers (like you) understand that a great price is nothing if it's not on a great trip. We hand select these departures on specific times to ensure a great trip at some remarkable savings..... but don't wait too long..specials change often and once they are gone, they are gone for good!
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Call our office to learn more!
August 28 - Sept. 1
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Round trip van transfers from Anchorage
4 nights lodging at our renowned riverside lodge
Come back in better shape than when you left!.
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Excellent spin or fly fishing options
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The Fall Combo: Start date 8/26
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All transfers, meals, lodging, nightly happy hour
Receive a copy of our exciting 2020 Legendary Adventures brochure in the mail and we'll have our 40 page catalog in the sent to you right away. In the meantime, dive into the online version, and please let us know if you have any questions! Our office staff has a combined 100 years of Alaska and worldwide adventure travel experience, and we'd love to put that knowledge to work to assist your planning.


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April showers have finally yielded May flowers. The Southern sun cascades down the cobblestone streets of downtown and the vast, beautiful scenery of Wrightsville Beach. While we welcome the warmer temperatures, the allergies seem to annoy. Yet, currently on display at New Elements Art Gallery hangs a great consolation—and without the use of Claritin.
"Organic Matter" features the work of Raleigh-based artists Kristen Dill and Kevin Bass, who both capture the colors, vibrancy and beauty of their natural surroundings. The two artists enjoy painting outside, but they operate on two opposite ends of the spectrum: Bass—whose work is abstract and gestural—contrasts and expertly complements Dill's more impressionistic, realistic renderings. Although their styles differ, Bass and Dill both create works that express unique visions of nature.
Kevin Bass grew up in Southern Pines, NC. His advantageous location as a youngster provided him access to explore both the mountains and the coast. Always interested in the arts, Bass' passion really began to evolve while attending Appalachian State University. He garnered a zest for the outdoors through nature explorations, which opened up new possibilities for his art.
At first his creations comprised an impressionistic style to capture the landscape around him, but studying art history indoctrinated his keen interest in the abstract. Bass began to explore techniques by merging the two styles together. His new works are completely conceptual.
"My work is deeply influenced by the mountains [and] flowers growing on a hillside or in a garden, and by the waves as they crash on the shore," he comments. "I soak up that visual information and then transfer those thoughts, feelings and images to my canvas."
Bass's work is textural, too, and combines acrylic and natural elements. "Texture, surface treatments, and color are very important aspects of my work," he describes. "[They allow] for each painting to have a very profound and compelling presence."
Approaching his work with an organized process, Bass layers paint over his original concept. "It helps to lay the foundation for the initial imagery and paves the way for the following applications of other mediums," he explains.
The following phases of his process incorporate a rhythmic application; he uses an expressionistic brushstroke to create balance and surface tension. He applies and removes layers of paint before adding elements such as sand and mica—evoking a sense of all that's found in nature.
"As the artist making the work, the unpredictability and potential discovery is very exciting," Bass states. "My ultimate goal is to create an impactful body of abstract art that engages the viewer."
In contrast to his notional, experimental approach, Kristen Dill's impressionistic watercolors represent naturalistic inspiration. Quickly creating paintings so as to accurately depict the sunlight, her pieces possess an immediate vibrancy and vitality.
"I am drawn to paint something because of stimulus, which may be a unique shape or an evocation of a feeling," she muses. "The painting becomes an expression which crystallizes psychological insight."
Dill found her draw toward nature after graduating from the University of Southern Maine. Subsequently, she spent five years there, exposed to the countryside landscapes previously captured by great American artists like Winslow Homer and Edward Hopper.
"I was drawn to and inspired by Homer's ability to evoke a sense of physical immediacy, and Hopper's expressive color and bold design," Dill says.
Finding ingenuity across the U.S., she has lived and worked in Dallas, Memphis, and now Raleigh. During the summer, Dill makes her home in Moose Pond in Bridgton, TN, where she experiences direct access to nature. Her old screen porch becomes a studio, much in the way Hopper and Homer worked. Using both oils and watercolors she cultivates striking, visually gripping works.
"I paint to capture the ephemeral quality of nature and make it a shared visual experience," Dill professes. "[I focus] mostly on organic shapes and layer vibrant color to intensify the viewer's awareness."
In celebration of the dissipation of winter, "Organic Matter" hones in on the natural world through two contrasting vantage points. This will be the final week it's on display at New Elements Gallery.
Organic Matter
Work by Kevin Bass and Kristen Dill
Hangs through May 17th
New Elements Gallery
201 Princess Street
Tues. – Sat., 11 a.m. – 6 p.m.


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Via Gawker, Access Hollywood asked Clint Eastwood about his now-infamous speech. His response:
"If somebody's dumb enough to ask me to go to a political convention and say something, they're gonna have to take what they get," the veteran actor told an Extra correspondent during a one-on-one interview about his upcoming film Trouble with the Curve...Asked if Mitt Romney was that "somebody," Eastwood initially said "yeah," before adding, "actually, he had some of his people ask."
The Islamo-fascist, radical atheist, communist bail-out, secular sharia wizard is cunning. And Hussein has many spies.
We want to hear what you think about this article. Submit a letter to the editor or write to firstname.lastname@example.com.
Ta-Nehisi Coates is a national correspondent for The Atlantic, where he writes about culture, politics, and social issues. He is the author of The Beautiful Struggle, Between the World and Me, and We Were Eight Years in Power.


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Synchronisation does not download any notes
Tomdroid on a no-name tablet running Android 4.0.4
Synchronisation attempt via Ubuntu One.
Tomdroid seems to connect to the server, showing the "Synchronisation in progress" pop-up, but not a single note is actually downloaded.
Both my other computers happily share and synchronise their notes using the Ubuntu One service.
Any help would be greatly appreciated.
Question information
- Language:
- English Edit question
- Status:
- Solved
- For:
- Tomdroid Edit question
- Assignee:
- No assignee Edit question
- Solved by:
- Stefan Hammer
- Solved:
- 2012-10-11
- Last query:
- 2012-10-11
- Last reply:
- 2012-10-11
Hi Holger,
Which version of Tomdorid do you use? A lot changed since the last Beta release (0.7.1). You could try the daily build from here:
If the problem sill exists, it would be nice to have a log! You can get one directly on your android device using any logcat viewer
eg: https:/
Only the second one worked for me on android 4.1 btw.
Alternatively you can also grab a log with your computer. you just need the adb binary therefore (from the Android SDK package)
Thanks for contacting us about this problem!
|Holger Nahm (holger-nahm) said :
Thanks Stefan Hammer, that solved my question.
|Holger Nahm (holger-nahm) said :
Dear Stefan,
Thank you very much!
The issue was apparently with my SD card, but logcat made finding that out no problem at all.
The new build is gorgeous!
I very much appreciate your effort with this fantastic program.
Best regards,
Holger Nahm


text:
Export 1 results:Author Title Type [ Year]
Filters: Author is Nelson Ko [Clear All Filters]
Open Source as Community. Open Source Business Resource, (September 2007). http://timreview.ca/article/782007.
Copyright © Talent First Network 2007–2020 ISSN: 1927-0321 Formerly the Open Source Business Resource
The Technology Innovation Management Review is published under a Creative Commons Attribution 3.0 Unported License. Authors retain full copyright to their individual works.


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Stroke Falls to No. 5 Cause of Death in US
Stroke has dropped from the nation's fourth-leading cause of death to Number 5, according to new federal statistics. It is the second time since 2011 that stroke has dropped a spot in the mortality rankings.
According to the Centers for Disease Control and Prevention report, stroke swapped positions with unintentional injuries, which killed 1,579 more people than stroke in 2013. The stroke death rate dropped slightly, from 36.9 percent in 2012 to 36.2 percent in 2013. While the death rate from heart disease dropped somewhat between 2012 and 2013, it remains the Number 1 cause of death in the nation. Cancer is the second-leading cause of death, followed by chronic lower respiratory diseases.
The decline in stroke deaths may be due in part to improvements in treatment and prevention, said Ralph Sacco, MD, past president of the American Heart Association and chairman of neurology at the University of Miami Miller School of Medicine.
"There are more stroke centers now operating in the US, and the acute care of stroke is improving," said Dr. Sacco, who in 2010 became the first neurologist to be named American Heart Association president. "However, although mortality from stroke is dropping, we know that the number of people having strokes in the US is rising each year due to the aging of our population and other signs that strokes have increased in younger groups."
Indeed, despite the lower death rate, 432 more people died from stroke in 2013 than in 2012, the report found.
Stroke also remains a leading cause of disability in the US. In fact, the number of people having strokes – often with painful and debilitating after-effects – remains a major cause of concern. "Stroke is more disabling than it is fatal," said Dr. Sacco.
One In Five Adult Epilepsy Patients Have ADHD Symptoms
Nearly one in five adult epilepsy patients reports attention deficit hyperactivity disorder (ADHD) symptoms, a new study finds. This is four times higher than the approximate 4.4% rate of ADHD diagnosis in the general adult population.
Those in the study who experienced ADHD symptoms also reported higher rates of anxiety, depression and worse seizure frequency. The study, which involved 1,361 adult epilepsy patients, is published online in Epilepsia.
"Little was previously known about the prevalence of ADHD symptoms in adults with epilepsy, and the results were quite striking," said lead author Alan B. Ettinger, MD. "To my knowledge, this is the first time ADHD symptoms in adults with epilepsy have been described in the scientific literature.
Dr. Ettinger pointed out that those who reported ADHD symptoms were nine times more likely to have depression and eight times more likely to have anxiety symptoms. They were also far less likely to be employed than others.
"This study reinforces the fact that we have to broaden our view of what epilepsy entails," he said. "Our patients may also have psychiatric comorbidities, and screening for and treating these may make a great difference to patients in their family, school and work lives."
Phase II Study of ALS Drug Begins
A Phase II study of the novel molecule sNN0029 to treat Amyotrophic Lateral Sclerosis (ALS) has been initiated.
sNN0029 is a recombinant human vascular endothelial growth factor (rhVEGF-165) that is administered intracerebroventricularly (ICV). Administration of sNN0029 in animal models of ALS increased survival of motor neurons that degenerate and are a leading cause of the disability and symptoms in patients with ALS. Animals with the G93A-SOD1 mutation, known to be associated with ALS in humans, who receive rhVEGF-165 survive longer and show improved muscular strength compared to controls. Based on its mechanism of action, i.e. direct and indirect effects preventing death of motor neurons, sNN0029 may represent a unique treatment opportunity for patients with ALS.
An earlier study of sNN0029 in ALS patients at doses up to and including 2μg/day indicated in preliminary analyses evidence of significant benefit especially in patients at the highest dose on multiple efficacy measures, compared to placebo. Treatment with sNN0029 was well tolerated and many patients have received treatment for up to two years and more.
The new study will include patients with ALS who will receive 4μg/day as a continuous treatment in a randomized, placebo-controlled double blind fashion using an implantable pump and brain catheter. The trial has been approved by Health authorities and is currently recruiting patients to clinical sites in Belgium and the Netherlands. It will enroll 18 patients who will be assessed for safety and efficacy for three months as part of this study. Multiple clinical safety and efficacy rating scales will be used in combination with biochemical analyses and neurophysiological examination.
FDA has approved Duopa (carbidopa and levodopa) enteral suspension for the treatment of motor fluctuations for people with advanced Parkinson's disease. Duopa is administered using a small, portable infusion pump that delivers carbidopa and levodopa directly into the small intestine for 16 continuous hours via a procedurally-placed tube. It was approved by the FDA as an orphan drug.
"There is unmet need for treatment options for patients with advanced Parkinson's disease. As the disease advances, it can be difficult to control motor features," said C. Warren Olanow, MD, Professor, Department of Neurology and Department of Neuroscience, Mount Sinai School of Medicine, and lead investigator of the DUOPA pivotal trial. "In clinical trials, DUOPA was shown to significantly reduce the amount of off time advanced Parkinson's disease patients experienced."
The DUOPA approval is based on a Phase 3, 12-week, double-blind, double-placebo, active control, parallel group, multi-center trial (N=71) that compared the efficacy and safety of DUOPA to oral, immediate-release (IR) carbidopa-levodopa tablets in advanced Parkinson's disease patients. The study showed that DUOPA significantly reduced daily (per 16 waking hours) mean "off" time at 12 weeks by four hours, which resulted in an average of 1.9 fewer hours of "off time" when compared to carbidopa-levodopa IR tablets.
Treatment with DUOPA was also associated with an improved mean "on" time (periods when the medication is working and symptoms are controlled) without troublesome dyskinesia (uncontrolled movement that does not interfere with normal daily activities) by four hours at 12 weeks, which resulted in an average of 1.9 hours more "on" time when compared to carbidopa-levodopa IR tablets. The most common adverse events (>7% and greater than carbidopa and levodopa immediate release) were complication of device insertion, nausea, constipation, incision site erythema, dyskinesia, depression, post procedural discharge, peripheral edema, hypertension, upper respiratory tract infection, oropharyngeal pain, atelectasis, confusional state, anxiety, dizziness and hiatal hernia.
Nearly two years after it was first rejected, FDA has approved Rytary, an extended-release oral capsule formulation of carbidopa-levodopa, for the treatment of Parkinson's disease, post-encephalitic parkinsonism, and parkinsonism that may follow carbon monoxide intoxication and/or manganese intoxication. Rytary is not for use in patients using nonselective monoamine oxidase inhibitors (MAO) inhibitors.
"The FDA approval of Rytary is an important new development for the treatment of Parkinson's disease and provides an extended-release carbidopa-levodopa product that treats Parkinson's disease," said Fred Wilkinson, president and CEO, Impax Laboratories. "Rytary is designed to address one of the most significant unmet needs for patients living with Parkinson's disease, which is to reduce the amount of time during the day when their symptoms are not adequately controlled."
The drug contains immediate release and extendedrelease beads, with a specific amount of carbidopa and levodopa in a 1:4 ratio, and provides both initial and extended levodopa plasma concentrations after a single dose. It may be swallowed whole or, for patients who have trouble swallowing, the capsule may be opened and the beads sprinkled on applesauce and consumed immediately.
Impax, the company behind the drug, expects the four strengths of Rytary, 23.75mg/95mg, 36.25mg/145mg, 48.75mg/195mg, and 61.25mg/245mg (carbidopa/ levodopa) to be available for commercial distribution in February 2015.
The Rytary clinical program studied patients with early (levodopa-naive) to advanced Parkinson's disease in the U.S. and in Europe. In APEX-PD (Study 1), a trial that enrolled and randomized 381 levodopa-naive patients, the study met its primary efficacy endpoint of mean change from baseline in the sum of Unified Parkinson's Disease Rating Scale (UPDRS) Part II (activities of daily living) score and UPDRS Part III (motor skills) score for Rytary versus placebo at Week 30 (or early termination).
The most common adverse reactions with Rytary in the APEX-PD trial (in at least 5% of patients and more frequently than in placebo) were nausea, dizziness, headache, insomnia, abnormal dreams, dry mouth, dyskinesia, anxiety, constipation, vomiting, and orthostatic hypotension. The most common adverse reactions with Rytary in the ADVANCE-PD trial (in at least 5% of patients and more frequently than an oral immediate-release carbidopa- levodopa) were nausea and headache.
FDA has granted Fast Track designation for deflazacort in the treatment of patients with Duchenne Muscular Dystrophy (DMD). DMD is the most common and severe form of muscular dystrophy among children. There are currently no approved therapies for the disease in the US.
Deflazacort is a glucocorticoid with anti-inflammatory and immunosuppressant properties. Based on previous studies, it appears that deflazacort may be a new treatment option for patients with DMD. Side effects reported to date include cushingoid appearance, irritability and cataract formation.
Marathon, the company behind the therapy, is currently conducting clinical and preclinical studies of deflazacort to support approval in patients with DMD. A NDA is anticipated in early 2016. FDA previously granted Orphan Drug designation to deflazacort for the treatment of DMD.
Audible Pill Compliance System Available
MedCenter System is a newly created talking system to increase compliance with daily medications using the date of the month. This system emphasizes the "Date" rather than the "Day of the Week." The "Date" is located on each pillbox and pill cavity, the visual display of the clock, and as an audible notification during the alert messages. "This repetition of the "Date" helps ensure proper medication compliance, even when the user is unsure what day of the week it is," according to the company. The system has a suggested retail price of $69.95 with the talking LCD clock and $34.95 without it.
Phase III MS Trial Underway
Receptos has enrolled the first patient in the SUNBEAM Phase III trial of RPC1063 in patients with relapsing multiple sclerosis (RMS). The company had previously initiated the Phase III portion of the RADIANCE trial in patients with RMS. Receptos is on track to complete this Phase III clinical development program in 2017.
In a Phase II trial of RPC1063 in RMS, RPC1063 met the primary endpoint of reduction in MRI brain lesion activity as well as secondary endpoints measuring effects on other MRI parameters. The overall safety profile of RPC1063 was consistent with results of prior trials.
RPC1063 is a novel, oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptor modulator in development for autoimmune indications including RMS and ulcerative colitis.
Study: Lack of Data on Opioid Drugs
A National Institutes of Health white paper released January 15 finds little to no evidence for the effectiveness of opioid drugs in the treatment of long-term chronic pain, despite the explosive recent growth in the use of the drugs.
The paper constitutes the final report of a seven-member panel convened by the NIH and finds that many of the studies used to justify the prescription of these drugs were either poorly conducted or of an insufficient duration.
Dr. David Steffens, co-author and chair of the psychiatry department at UConn Health says, "there's no researchbased evidence that these medicines are helpful." He notes a need for better communication about best practices to physicians who prescribe these drugs.