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As education continues to change, so does the way we teach and how our students learn. Instead of the teachers being the holder of all information, our students now have the resources to drive their own learning. Personalizing learning for students allows students greater opportunities to control their learning and search for what suits them, and my Virtual Tour event focuses on what personalized learning looks like at Mason High School. (more…)
Payson High School, Part 2: Building a School Culture of Responsibility through Embedded Intervention
Guest post by Jeff Simon
Last week, I discussed the importance of building a positive school culture by utilizing a one-hour lunch period for clubs and activities that foster school pride and for innovative labs that encourage enthusiasm for learning. This week, I will share how we've built a culture of personal responsibility at Payson High School by providing a positive support system for student learning through embedded intervention.
Take the Challenge
The questions came in fast and furious on Twitter during the conversation between Carol Dweck, author of Mindset and the Lewis and Virginia Eaton professor of psychology at Stanford University, and Daniel Wong, author of The Happy Student: 5 Steps to Academic Fulfillment and Success, during the opening Thought Leader session at Ignite '14.
Former National Principals of the Year Laurie Baron, superintendent of Evergreen School District in Montana, and Trevor Greene, professional development specialist for the Association of Washington School Principals, facilitated the discussion on stage and on Twitter. The results of this engaging live/virtual discussion are presented below. (more…)
School Showcase Models Community Values
The schools who presented in the school showcase at NASSP's Ignite '14 brought a little piece of themselves to share with their colleagues. I was fortunate enough to attend three of the packed sessions and came away having experienced a bit of what happens in each school.
It may not be common for professional development sessions to begin with singing, but maybe it should be. The native song that started the session with the Native American Community Academy (NACA) in Albuquerque, NM, established the reverence for community, identity, respect, and balance that characterizes the school and its leaders. (more…)
New Family Tours: Do They Get What They Expect?
Guest post by Jimmy Casas:
I still remember the day I received the phone call offering me the principal position at my current school. That was twelve years ago! I can honestly say, like many of you, I have invested my life into our school community in many ways. Growing up, my parents demanded hard work. They expected it, they modeled it, and they lived it. They convinced me that hard work was the key to success. They took immense pride in the fact that what they lacked in education, they made up for it in terms of work ethic. My father would often holler at me, "You get out of it what you put into it!"
Ironic how the things our parents said to us when we were children often return full circle, not only in our expectations, but in how we behave. They even get passed down from generation to generation at the expense of our own children sometimes, which I am sure my kids would attest to. His words have hung with me all of my life, sometimes to a fault. Sometimes though, his words move me in a way that makes me proud to be his son because his words make up a part of who I am.
Last week I had the distinct privilege of touring three new families who were trying to decide which school to enroll their children in. Like the hiring process (of someone wanting to teach in our school), the idea of a family possibly wanting to enroll their student in our school gets me jacked up! It is something I look forward to so much that at times I literally cannot sleep the night before because I cannot wait to get to school the next day and share our school community with them. I do not apologize for my energy, my passion, or the excitement I share with the families when they visit. I am proud! I am proud of what our school has to offer our students, our staff, our families, and our community. I once had a visiting superintendent tell me that although the school was a large school, it had a small school feel to it. That was the biggest compliment anyone could have given us because to me it meant that it felt like a caring community. I have never forgotten that comment and to this day aspire to maintain that same feeling in our school.
I am always honored when I am able to take time and showcase our school community. Here are a few examples of our best and next practices in touring new families:
- Schedule the building tours with the principal – In many high schools, this practice is often delegated to a school counselor or other building administrator. I have always wondered why any principal would not take advantage of the opportunity to be the first person to welcome a new visiting family or more importantly, to spend time getting to know a potential new student. Think about the message you are sending when you won't give a new family and student 90 minutes of your time. Mindset: Models to student and family they are the most important people walking through our doors every day.
- Office secretaries can make or break the deal before a new family ever walks in the door – Don't ever underestimate the importance of the impact your office secretaries can have on a new family regarding their choice for a new school when they are calling to inquire about a visit/tour. A positive first impression goes a long way with parents and a negative first impression will quickly decrease the chance of a new family selecting your school ten-fold. Trust me. I have had many families tell me they crossed off school XYZ because of the way they were treated by the Principal's secretary. Mindset: No student or family who calls or enters the main office is an inconvenience. In fact, they are the purpose of why we are here. Never forget that.
- Tours should be scheduled during the school day – If at all possible, I would encourage you to schedule all visits during the school day. It is critical for the visiting student and his/her parents to get a feel of the climate in our school and what #BettPride is all about. This is nearly impossible to simulate without students in the building. I want them to experience first-hand how welcoming our students & staff are to new students. I want them to see how our school community cares for one another and values the teaching and learning that transpires throughout the building on a daily basis. Mindset: Be proud of the school community in which you spend most of your waking hours and deliver your message with passion, purpose and with a humbled spirit.
- Spend time getting to know the student – I will often spend the first 15-20 minutes talking to potential new students one on one in my office before a tour in order to learn as much as I can about their talents, strengths and areas of interest. Two questions I ask new students are, "What part of school do you value most and why?" and "How do you want to be remembered when you leave your high school?" Mindset: Want to show students that this is an environment of great expectations that will challenge their inner core and expect them to leave a positive footprint on their school community long after graduation.
- Always be yourself – Be sure when giving a tour you conduct yourself in the same manner you would if you were walking the building on a normal day. In other words, be you. This is not the time to try and portray a side of you that is not genuine. By doing so, you will quickly lose the trust of your new family and send the wrong message to your current students and staff. Mindset: Rather than be disingenuous, use these opportunities to recognize areas for potential growth in your own leadership style and then establish a plan to make a needed change.
- Encourage them to visit other schools – Believe it or not, I always encourage new families to visit the surrounding school districts. I emphasize to new parents that there are many good schools in our area to choose from and that it is important for them to contact other schools to schedule visits. Honestly, I tell them they need to walk into different schools and determine for themselves, which school community "feels right." I want a new student (and their parents) to feel good about his/her choice in a new school knowing full well I may lose them, but in the long run it is the best measure of success. If they do not select us, then it wasn't the right fit. Mindset: I believe the most critical factor in determining the success of any student is the culture and climate of a school. My attitude going into any meeting with a new family has to be one of quiet confidence and trust that we have cultivated the right culture for kids to be successful and that new families will feel that this is a special place.
- Let them ask questions of the students and staff – I always encourage our new families to ask students and staff questions as we tour. In fact, I will often purposefully distance myself so our students and staff can have an open and honest discussion with new families free from my presence. In addition, I tell families before we begin the tour that they are welcome to enter any classroom they choose and that our students and staff do not know they will be visiting. Mindset: I never want to give the impression that I am somehow trying to influence the responses or comments from my students and staff. I want them to know that what they see is what they get; this is who we are every day.
- Show new families where to find your school/district data – At the conclusion of the tour, I always return to the main office to give the student and family time to digest what they have just observed and to provide an opportunity for any follow up questions. This is also the time I provide families our school profile data information or walk them through on how to access the information from our district/building website. Mindset: I want to be transparent with our school data, although I find most families have already accessed it long before ever setting up a visit.
- Share your personal information with them – Parents always appreciate when I hand them a business card and take time to inscribe my personal cell phone number on the card and encourage them to contact me day, night or weekend. I share with them that I recognize that choosing a school can be very stressful on not only their student, but the entire family as well. Mindset: I want parents to know I care about them and their student and am accessible 24/7 should a need arise sooner than later. The message I want to send is that being a school principal is not a job, but my life.
- Invite them to a school function – One of most positive steps we take to encourage new families to select our school is to invite them to attend an evening event as our special guest. This is especially true if the event they attend is an event in which the student has a personal interest. This is one area that we added on as part of our practice this year after seeing tremendous results of families selecting our school after attending one of our events. Giving a new student an opportunity to see and feel what it would be like to be part of a club, group, or team is a powerful way to let them experience the pride and spirit of our school community. Mindset: Allows students and families to see up front the value we place on our co-curricular activities. We want our students to not only feel connected, but be connected beyond the bell schedule.
I approach every student/family visit with the intention of giving of my time and more importantly, of myself. I have tremendously high expectations of myself and of my staff when it comes to cultivating a culture that places a significant value on giving of our time to others in a positive and caring way. My mindset is simple; in the words of my father, we as a school community will get out of it what we put into it.
As leaders, we are responsible for raising the bar to exceptionally high levels when it comes to how we want both new and existing families to feel about their school community. I am honored to be a part of this wonderful community we call Bettendorf and I am extremely proud because I know that although I have invested my life in our school community, I am just a guest like everyone else until the next principal comes along.
So I challenge you to reflect…do your new families get what they expect?
Or do they walk out of your school receiving so much more than they ever expected?
This entry is a cross-post from Jimmy Casas's blog. (@casas_jimmy) Principal of Bettendorf High School, will present Building Community Through Social Media on Friday, February 7, 2014 at Ignite '14 in Dallas. For more information and to register visit www.nasspconference.org.
School Showcase Feature: Woodbridge Middle School
Creating sustainable, quality education programming is a driving force for all public schools. We all look deeply and rationally at our students, striving to identify their needs. However, with all that is before us, it can seem like an overwhelming task. Here at Woodbridge Middle, we spent some time researching, analyzing, and planning such a program that would benefit students regardless of their achievement level or demographic. With this in mind, we established an opt-in Same Gender Program based on the research of Dr. Leonard Sax.
Currently fifty percent of the students at our public, coed middle school receive their instruction in language arts, math, science, and social studies in an all-boy or all-girl setting. We have multiple learning community structures in place which extend beyond simply building time in the master schedule so that teams and departments can meet. Our structures provide opportunities for teachers to constantly examine how we do business, what impact we have on students, and what we need to consider for improvement as we move forward. Our goal is to continuously search for better ways to meet the academic, emotional, developmental, and social needs of our students. Our Same Gender Program is one example of how we have worked together to meet the needs of our students.
The all-boy program's objective is to establish an environment in which middle school boys can learn best. Through research and student observations, we have developed an active, kinesthetic-learning environment where boys can succeed. An all-boys lesson modifies the topics, activities, and instructional delivery to increase student engagement. Within the all-boys program, we have developed a House System where students participate in healthy competition in both academics and extra-curricular activities. The House System also serves as our behavior management tool, in which students take ownership of their own behaviors and adjust their social tendencies. At the conclusion of our program, we hope to develop young men with good character and the motivation to succeed.
Similarly, we have developed an all-girls program with the aim of building leadership, integrity, and self-awareness. By excluding the distraction of gender stereotypes and building upon gender differences, we have, as Dr. Sax put it, "got beyond pink and blue." We see girls as individuals and understand that they do not need to be trapped by certain feminine stereotypes, such as "girls are not good at math and science." Instead, we create opportunities that allow them to succeed by modifying their environment. For instance, we expose students to female scientists, mathematicians, and authors in the hopes of providing examples of greatness. We also utilize texts with strong girls as major characters who have attributes with which they can identify.
Additionally, we spend a great deal of time providing a safe place where girls can express themselves without the fear of failure or competition. As reporter Sara Rimer of The New York Times explained, "being an amazing girl often doesn't feel like enough these days when you're competing with all the other amazing girls." Our teams seek to reduce the anxiety many girls experience by citing mantras such as Failure Leads to Success, Be Flexible, and Practice Balance. These keys of excellence help the girls release the deep-seated feelings of insecurity many of them have experienced throughout their academic and social careers. It also gives them permission to take risks where they may not historically have done so.
The middle school experience can be isolating and overwhelming for many students. By understanding how boys and girls learn differently, our school has created a welcoming place where All are Respected and Achievement is Expected regardless of gender, demographics, and other characteristics. While we have by no means perfected the model, we are confident in its effectiveness and continue to build upon our successes.
Woodbridge Middle School will be one of 22 schools featured at the Breaking RanksSchool Showcase at Ignite 2014. The Woodbridge team will be presenting A Same Gender Option: Boys and Girls are Different! on Thursday, February 6th. For more on Tefft Middle School, check out the article published in the May 2012 issue of Principal Leadership.
School Showcase Feature: Tefft Middle School
At Tefft Middle School, we have a motto: Moving all students forward, whatever it takes… together. This motto has been our driving force in how we approach student learning and success.
Moving All Students
Tefft serves a diverse population of students. We strive to make all of our students feel comfortable in our building, to think of it as a second home. It is our goal to ensure that all of our students grow during their time with us, no matter their ethnicity, language, special needs, or income.
Whatever It Takes
Strategic supports, interventions, and initiatives help us to meet the needs of every student.
Data transparency is one thing had has contributed to our great success. Student data journals let the students analyze scores of school, district, state, and national assessments, decide what they did well and what can be improved, and make goals for that improvement. Their data means something to them and becomes more than just numbers to take home.
When students bring their families to school for student-led conferences, they demonstrate ownership over their work by creating portfolios to share with their parents. Parents hear about their children's progress right from their mouths, and students feel accountable for their own progress. Parents are able to ask questions and help their children set goals.
In addition to these two initiatives, we also have common learning targets and academic vocabulary, which hold students to high standards and provide them with continuity of learning. Daily intervention classes, which utilize software for those students who are below grade level in math or reading, provide additional practice in the skills students need to grow. Common assessments in each class provide us—and students—with data to help set goals and drive instruction.
Grade-level teams share the same students and therefore provide close relationships and a feeling of family within the school. Department teams ensure continuity of content and push each other to improve student performance. Professional learning communities at faculty meetings allow staff to discuss issues from all points of view and analyze student data. Our parent-teacher group provides parents the opportunity to share ideas about their children's education.
Taking on challenges and initiating change based on our data helps us continually strive for success.
Tefft Middle School will be one of 22 schools featured at the Breaking Ranks School Showcase at Ignite 2014. The Tefft team will be presenting Harnessing the Power of Transparency and Data to Create and Sustain a Culture of Accountability on Thursday, February 6th. For more on Tefft Middle School, check out the article published in the May 2010 issue of Principal Leadership.
School Showcase Feature: Bloomfield High School
Guest post by Chris Jennings:
What happens when you create an opportunity for students to choose where they will go and what they will do during the school day? Chaos? Anarchy? At Bloomfield High School in New Jersey, we discovered that students may surprise you.
During the 2011-12 school year, a group of students and administrators met throughout the year to discuss how we could work within the confines of our existing seven-period day to create more opportunities for students to have independent time for clubs, extra help, and teacher meetings. When I opened the discussion to the staff, one of our teachers recommended we take a look at Princeton High School's "Wednesday" schedule. We did, and we adopted a similar schedule for the 12-13 school year. We have not looked back.
The basic premise is this: Each Wednesday, we shorten each period by eight minutes to allow for an activity period that runs during normal school hours – in our case, from 1:40-2:35. During this period, every school employee is unencumbered and available for students. Teachers and counselors can meet with students individually, in small groups, or as a whole class. Tests are retaken or made up, labs are completed, homework is done, and questions are answered.
You get the picture – but the catch is that at 1:40 school is dismissed, and students can choose whether or not they participate in the activity period. This is the part that made the grown-ups nervous. What if they all choose to leave? It took a leap of faith, but a year and a half later we consistently have 1,000 students choosing to stay in school and work with teachers. We relax school rules about hats, iPods, and cell phones during this period, and students are allowed stay for just ten minutes or beyond the duration of the period. We trust students to make decisions that are in their best interest, and they genuinely appreciate having the freedom. In my seven years as principal at BHS, I have not been involved in another decision that has been so universally accepted by students, teachers, and parents. The Wednesday Activity Period has become an important component of our approach to differentiate school for our students.
Chris Jennings is the principal of Bloomfield High School. Bloomfield High School will be one of 22 schools featured at the Breaking Ranks School Showcase at Ignite 2014. The Bloomfield team will be presenting Transforming a Title I High School through Culture, Collaboration, and Curriculum on Thursday, February 6th. For more on Bloomfield High School, check out the article published in the May 2012 issue of Principal Leadership.


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Another NewFronts, yet another brand-safety scandal.
In a scene that could be taken straight out of the movie "Groundhog Day," YouTube will once again find itself having to quell advertisers' fears during its NewFront presentation next week. The Google-owned video behemoth enters the pitch-a-palooza after reports surfaced last week that it ran ads from over 300 companies and organizations on extremist channels that promote white nationalists, conspiracy theories and North Korean propaganda, among others.
Certainly, YouTube is familiar with this song and dance. In the weeks leading up to the 2017 NewFronts, a bevy of advertisers including AT&T and Walmart boycotted the company when it was discovered their ads were showing up on racists and terrorist videos.
At the time, YouTube said it was installing safeguards to protect advertisers from unknowingly associating themselves with controversial content. Ultimately, it didn't appear to impact last year's negotiations. But what's happened since then? YouTube CEO Susan Wojcicki will need to offer more than the very brief apology she issued media buyers and their clients at last year's hoopla.
"No one platform is 100 percent safe," says Tara Walpert Levy, VP of agency and media solutions at Google. "I think everyone appreciates this is a journey, but clients feel good about the progress."
Taking on TV
Walpert Levy says many customers have regained their confidence in YouTube since last year after the company issued several changes to help protect brands from appearing in controversial content. This includes algorithmic changes, as well as ensuring that those ads that run as part of its Google Preferred package only appear in videos that have been verified by a human.
Procter & Gamble reportedly returned to advertising on YouTube last week, albeit much more selectively, after pulling its ads last year.
YouTube, which is moving its dog-and-pony show to the iconic Radio City Music Hall (NBC Universal will also host its upfront presentation there just over a week later), will continue to take on TV by promoting its reach. And buyers predict it will begin offering the two minutes of commercial inventory an hour it can sell to advertisers in its live TV service.
Walpert Levy declined to comment on announcements regarding YouTube TV. But she says six-second ads will play a bigger role this year on regular YouTube.
Of course, YouTube's drama is nothing compared to Facebook's Cambridge Analytica scandal. The political data firm that worked for Donald Trump's presidential campaign reportedly drew on improperly obtained data on more than 80 million Facebook users.
While Facebook will not present during the IAB-run Digital Content NewFronts, it will nonetheless be as much a part of the conversation as any of the brands in the lineup.
Brand safety is the predominate theme
Digital publishers are expected to come to the table with one of two messages, according OMD's chief digital officer Ben Winkler: We are better than TV or we are better than YouTube. The first argument plays on TV's ratings erosion and the ability for digital to precisely target audiences. While those that claim they are better than YouTube will be emphasizing their ability to deliver premium, brand-safe content.
"NewFronts have always been about legitimacy and about an industry that has something to prove," Winkler says.
Hulu certainly falls into the camp of boasting about how it outperforms traditional TV.
Even as TV networks like NBC and Fox make announcements about trimming commercial loads next season and improving their ability to target more precise audiences beyond Nielsen age and gender, Peter Naylor, senior VP of ad sales at Hulu, says he will remind the audience at Madison Square Garden that TV networks will still have twice as many ads per hour as Hulu and 100 percent of Hulu's audience is internet delivered, meaning everything can be targeted.
Hulu comes to the NewFronts this year with a new CEO: Randy Freer joined the company in October from Fox Networks Group where he served as president and chief operating officer.
Hulu will begin packaging its two minutes of commercial inventory it has available to sell as part of its live TV service during this year's negotiation, with plans to incorporate dynamic ad insertion – the ability for marketers to swap out ads and serve different creative to different viewers based on a variety of factors – this summer, Naylor says. The company plans to sell the inventory in its live stream the same way it sells its on-demand inventory, by audience, according to Naylor. It will not offer targeting by show or network.
Naylor will also make some announcements around measurement and attribution, but declined to elaborate.
TV players again talking digital
Viacom, ESPN and Meredith will need to prove they are legitimate digital businesses, OMD's Winkler says.
As is typically the case, every year a handful of traditional TV players take to the NewFronts to talk up their digital efforts. It's a move that's become increasingly perplexing as TV networks boast their ability to seamlessly integrate both their traditional linear and digital offerings.
Viacom is hosting its first NewFront following several major digital initiatives over the past year, including the launch of its content studio and the acquisitions of influencer marketer WhoSay and online video event VidCon. It will surely talk up how its content studio is developing programming specifically for platforms like Snapchat, which it renewed its deal with last week.
And ESPN joins the fray following the release earlier this month of its direct-to-consumer subscription service ESPN+.
Verizon-owned Oath will need to prove it is a legitimate competitor to the duopoly of Google and Facebook, Winkler says, while Vice Media will need to prove it has reformed.
Vice's presentation will most certainly be diametrically different than in years prior. During last year's soiree there was a boxing match between Eddie Huang, host of Viceland's" Huang World," and Vice's chief of staff and producer Niall Cooney. And in 2016 former CEO Shane Smith laid down on stage and admitted he drank "a few ales."
This year's gathering is expected to be more subdued following a spate of executive firings after the New York Times in December reported on complaints of sexual assault and harassment and a "boy's club" culture.
Among those who will be making appearances is Nancy Dubuc, former A&E Networks CEO who is taking the helm of Vice from Smith. She isn't expected to speak during the presentation, but her presence is surely a reminder that change is coming.
Twitter goes live
Twitter is returning for its second NewFront pitch, after last year it announced partnerships with 16 sports, news and entertainment companies to live stream programming. The big question will be how many of these partnerships will be renewed and which resonated with users.
Matt Derella, global VP of revenue and content partnerships at Twitter, pointed to the success they have had with Bloomberg's "TicToc," BuzzFeed's "AM to DM" and partnerships with the NBA, NFL and MLB.
Live will of course be a centerpiece of Twitter's announcements next week. As part of this, Twitter will be introducing ways it can help brands be broadcasters, Derella says. While many marketers were eager to go live when Facebook first introduced its Live feature, the hysteria has faded substantially. It will be interesting to see how Twitter tries to bring it back.
The company will also be exploring more on-demand content, Derella says, pointing to highlight reels it will be producing with Fox Sports during the World Cup.
And Twitter will develop content around some communities that have formed over the past year that reflect the movements that are happening culturally, according to Derella. While he declined to comment on specifics, it is likely there will be content related to the #MeToo and #TimesUp women's movement, among others.
The Gray Lady goes Hollywood
As The New York Times looks to convince video buyers they are focused on storytelling, the news behemoth will make a push into Hollywood. "The thing 'The Daily' taught us is the real differentiator for the Times is the talent and the stories they tell," says Sebastian Tomich, global head of advertising and marketing solutions at The New York Times. "How they got to the story is just as powerful as the story itself."
Tomich declined to elaborate until the presentation next week, but said the Times will be leaning into the entertainment world. The New York Times will also focus on its investment in business news, Tomich says. "It's the biggest bet we are making and there will be a lot of investment in that space."
This year's IAB-hosted NewFronts in New York City will run just one week instead of its typical two weeks. There will also be a West Coast-based event in the fourth quarter.
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CORRECTION: An earlier version of this article misidentified Bloomberg's video channel on Twitter as Tick Toc. Its name is TicToc.

subset: commoncrawl


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Objective: Bisphosphonates are used for treating osteoporosis. Few studies have reported their effect on alterations in comorbid behaviour such as depression. Therefore, present study was performed to investigate the effects of bisphosphonate drugs on depression in adult male Wister rats and Swiss albino mice.
Methods: The study was conducted on adult male Wister rats and Swiss albino mice, 36 of each type, equally divided into six groups. One group was classified as control group and the rest were treated as test groups. Initial photoperiod of 12 h was provided for acclimatization, prior to the start of the experiment. Drug administration was not performed in control group. Forced swimming test and tail suspension test were performed to investigate the antidepressant activity. Locomotor activity was performed to evaluate the action of drugs on the nervous system. Effects of the test drugs were compared with a standard drug—amitriptyline. Results were statistically evaluated by one-way analysis of variance followed by Bonferroni's multiple comparison test. P≤0.05 was considered significant.
Results: In forced swimming test, duration of immobility was significantly reduced in the standard and test drugs when compared to control group; however, it was not significant in all the four test groups as compared to that of amitriptyline-administered group (p>0.05). In tail suspension test, significant decrease (p<0.01) in the duration of immobility was observed with administration of drugs when compared to control group. Results of test groups were not found to be significant as compared to amitriptyline-treated group (p>0.05). Mean values of amitriptyline-, alendronate-, risedronate-, ibandronate-and etidronate-treated groups failed to show significant difference (p>0.05) when compared to control group suggesting homogeneity among the groups.
Conclusion: Bisphosphonates appeared to have an antidepressant activity. More extensive research is required to substantiate and elucidate the role of bisphosphonates in behavioural disorders such as depression.
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23. D'Amelio P, Grimaldi A, Di Bella S, Tamone C, Brianza SZ, Ravazzoli MG, et al. Risedronate reduces osteoclast precursors and cytokine production in postmenopausal osteoporotic women. J Bone Miner Res 2008;23:373-9.
24. Pennanen N, Lapinjoki S, Urtti A, Mönkkönen J. Effect of liposomal and free bisphosphonates on the IL-1β, IL-6 and TNFα secretion from RAW 264 cells in vitro. Pharm Res 1995;12:916-22.
25. Bianchi M, Franchi S, Ferrario P, Sotgiu ML, Sacerdote P. Effects of the bisphosphonate ibandronate on hyperalgesia, substance P, and cytokine levels in a rat model of persistent inflammatory pain. Eur J Pain 2008;12:284-92.
26. Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 2013;70:31-41.
27. Nagashima M, Takahashi H, Shimane K, Nagase Y, Wauke K. Osteogenesis and osteoclast inhibition in rheumatoid arthritis patients treated with bisphosphonates alone or in combination with pitavastatin over an 18-month follow-up after more than 4 y of treatment with bisphosphonates. Arthritis Res Ther 2012;14:1-8.
28. David AA, Schoeber J, Houston RE, Mohl VE, Wildman KM. Hyperparathyroidism. Am Fam Physician 1998;57:1795-802.
29. Pamulaparthi A, Prathap VR, Banala M, Nanna RS. Experimental evaluation of antidepressant and antianxiety activities of aqueous leaf extracts of Senna alata (l.) Roxb. using in vitro animal models. Int Curr Pharm Res 2016;8:60-3.
30. Rodan DA. Bisphosphonates and primary hyperparathyroidism. J Bone Miner Res 2002;17 Suppl 2:N150-3.
31. Knight MJ, Hyatt PJ. The effect of bisphosphonates on calcium and parathyroid hormone levels in patients with primary hyperparathyroidism over 2 y. Endocrine Abstracts; 2006. p. 12 P2.
32. Gill R, Balaji O, Kumari MK, Amberkar MB, Udupa KS. Zoledronic acid: a mischievous suspect for liver injury. Asian J Pharm Clin Res 2016;9:3-6.
33. Kennel KA, Drake MT. Adverse Effects of bisphosphonates: Implications for osteoporosis management. Mayo Clin Proc 2009;84:632–8.
34. Tanvetyanon T, Stiff PJ. Management of the adverse effects associated with intravenous bisphosphonates. Ann Oncol 2006;17:897-907.
35. Papapetrou PD. Bisphosphonate-associated adverse events. Hormones 2009,8:96-110.
36. Diab DL, Watts NB. Bisphosphonate drug holiday: who, when and how long. Ther Adv Musculoskelet Dis 2013; 5:107–11.
37. Black DM, Kelly MP, Genant HK, Palermo L, Eastell R, Bucci-Rechtweg C, et al. Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur. N Engl J Med 2010;362:1761-71.


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This cycling itinerary (aslo possible on foot and/or by horseback) links; through the towing path and, then, the old traway road, the commercial and flowered Plancoët to the peninsula of Saint-Jacut-de-la-Mer and its eleven beaches. Along the way, you will discover remarkable sites of the valley's heritage and, mid-way, you'll cross the coastal bicycle road (V4)
The indicated distance and travel time are those of a one way only journey, the way back is possible by the same path by following the same direction signs (a green cyclist on a white sign)
(The suggested circuits are given as an indication and do not take into account the possible terrain or environment evolution. The users' personal responsability is engaged by the use of these itineraries, the Office de Tourisme disengages itself from any responsability regarding the use of the maps and possible accidents that may occur on the proposed itinerary.)
17 km
max. 43 m
min. 4 m
22 m
-18 m
Altimetric profile
Styles : HikingIn townSea
Public : FamilyCyclistsSchool
Theme : Patrimony
This easily flooded zone of the river's major bed was covered at almost...Read more
At the crossing of the D786 road, caution!
Take the path ahead. After 350m, the castle appears again. You can enter the ruins and discover the surrounding nature.
The club is opened all year round. You can rent kayaks...Read more
Dès 1223, les textes évoquent des moulins sur l'Arguenon. Du...Read more
The cycling road is a European project which will allow, after completion, to follow the coasts of Brittany, Normandy and of the South of England.
Going West you'll reach the sea resort of St-Cast, Fréhel Point, going East the cycling road from St-Malo to Vannes and Rennes.
At all time was Plancoët an important crossing point: First...Read more
The Office de tourisme is opened all year round and offers a personal welcome.
The peninsula is not frequented by cars much; it is easy to keep going by bicycles to the Pointe du Chevet or other beaches.
Two lodgings have obtained the "Accueil vélo" label which garantees the presence of facilities and informations to cycliststs : the abbey and La Manchette camping site.
This itinerary leaves Saint-Jacut peninsula and goes to the coastal cycling road through countryside paths.
You could say, while being in Plancoët that you are on the sea side,...Read more
This quite typical medieval religious site is made of a church, a...Read more
This path you'll follow for most of the way to the castle of le Guildo...Read more
This pastoral countryside path is for food lover ! Treat yourself...Read more
This gallery grave dates back to the Neolithic Era, between 3,000...Read more
L'ancien couvent des Carmes est situé au Guildo à proximité du gué...Read more
This old castle is built on a rocky peak at the mouth of the ria....Read more
We often speak of a fishermen's village. However what would have they...Read more
Grand Rue is the centre of the peninsula. That's where you will find...Read more
Previously Place du Calvaire (Calvary Square), then Place de la Poste...Read more


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Dear all
I have created a database at my workplace and my colleague required it to be locked. I used some security wizard but after trying to re-open the doc..the following error in title pops...and continues have your system administrator or the person who created the object establish the appropriate permissions for you.
I have 3 files
the original db (with the error)
a .bak file
and a security file (.mdw)
any help would be greatly appreciated...half day lost :(
Needless to say, you don't give a lot of information (like which version of Windows, which makes a big difference when it comes to permissions), so you won't be able to get a specific answer. First thought would be to make a copy of the 3 files (just in case of total screw-up), then change the suffix of the .bak file to whatever suffix your database is in and see if that opens. After that your only real option is to refer to the company that supplies the 'security wizard' Again, without knowing the name of the program help will be limited..
"I've always been mad, I know I've been mad, like the most of us..." Pink Floyd


text:
Property Details
353 Park Street West, Dundas, ON, L9H 1Z6, Canada
Take a look at this stunning Bungalow town home in the village of Dundas, within walking distance to all the charm and convenience that the downtown core has to offer. The freshly painted 2+1 bedroom, 2.5 bath town home has been professionally redesigned from top to bottom, paying special attention to detail and making perfect use of the living space by using design elements that are both modern and stylish.
Cathedral ceilings capture the abundance of natural light and are highlighted by slate floors, quartz countertops and exquisite finishes throughout. The open living and dining area leads out to a very private and large back deck and pergola, offering fantastic views of the escarpment and Dundas Peak. The beautiful custom kitchen has hand made Canadian quartz counters, modern cabinets with designer handles, & new appliances.
The master bedroom offers a walk-in closet and full ensuite. The laundry room, with a new counter and floor, is adjacent to the master. The lower level is very cozy and inviting, and was also redesigned with new bathroom, rec-room, and separate bedroom - perfect for extended family or guests.
Additional recent upgrades include new flooring, stairs & railings, roof, pillars out front, shower, oversized patio doors & more. This freehold town home offers almost 3,000 square feet of living space, is maintenance free, modern, and move in ready.
- Folsetter Taffs
- email@example.com
- RE/MAX Escarpment Realty Inc.
- 50 Dundurn St. S., Unit #119
- Hamilton, ON


text:
Organisational unit: Research Group
Chronic pain is a very complex phenomenon with a biopsychosocial background. It is important to gain insight into the mechanisms that contribute to chronicity or maintain this process. In this regard, it is important to study both the peripheral and central pain mechanisms.
The creation of this alliance research group will allow to link the research competencies and clinical expertise present in the participating partners. This collaboration should enable us to gain insight into the interaction between disorders in the sensorimotor control at the vertebral column and pain.
We are convinced that in this way we can build a strong joint research team that will undoubtedly lead to publications in highly-rated journals and will also increase the capability to acquire external funding.


text:
Following her emotional interview with Dolly Everett's parents, Tracy Grimshaw has urged viewers to consider another, often overlooked facet of school bullying.
Speaking on A Current Affair, the 57-year-old host issued a warning not to engage in a "verbal pile-on" with school bullies because they, too, are just children.
"A lot of you turned your comments on the bullies, but please remember that they are kids too and they all read social media," she said.
"That's a key point of this."
"It's not for adults to get involved in a verbal pile-on against a bunch of schoolkids."
Amy Everett -- affectionately known as Dolly -- took her own life after suffering a vicious campaign of bullying at the hands of her peers. She was just 14.
In a heartbreaking new interview with A Current Affair, her parents Tick and Kate recalled the unimaginable: the moment they discovered their daughter's lifeless body.
"There was nothing we could do," said Tick. "It's the most horrible thing you, anybody, any parent ... you just, you should never have to do that."
Owing to the isolation of their bushland family home, the parents were forced to wait for nearly four hours before emergency services arrived.
"You know, being isolated was another battle, you know sort of three and a half hours before anyone else could get there. The longest night of our lives really. You know, she's right there and there's nothing you can do."
"I actually just laid with her for hours," said Kate. "Cuddled up with her for hours and just, I just made a promise to her that, this wouldn't be in vain ... that I was so, so sorry that I hadn't made better decisions."
WATCH: Kate and Tick are determined to raise awareness of youth suicide in their beloved daughter's honour. Post continues...
"There was nothing I could do to save her. I don't know if anyone thinks this is the answer to their problems, it's not. It just gives them to somebody else."
"She had so much to live for," Kate continued.
"I wish she could see herself through my eyes and not through the eyes of the people who made her feel like that."
If you or anyone you know is suffering, please contact Lifeline (lifeline.org.au) on 1311 14 or visit Headspace at (headspace.org.au). Visit Beyond Blue at (beyondblue.org.au) or call 1300 22 4636. You can also contact the Kids Help Line on 1800 55 1800.


text:
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|Vol 7, No 1 (2019)
|Contested Sovereignty and Conflict: Between Spain and Catalonia
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|Yinka Olomojobi, Omoigerale Omonye
|Vol 6, No 2 (2018)
|How russian intervention in syria redefined the right to protect in armed conflict
|Abstract PDF (Eng) similar documents
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|"... in armed conflict. The objective was realised in 2005 after the UN adopted the Right to Protect (R2P ..."
|Vol 3, No 4 (2015)
|Abstract similar documents
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|"... immediately after the armed conflict or during a rational time span since its occurance. In this respect ..."
|Vol 3, No 4 (2015)
|Self-Defense in Karabakh Conflict?
|Abstract PDF (Eng) similar documents
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|"... conflict or during a reasonable timeframe since its occurance. In this respect, emerging Karabakh Conflict ..."
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text:
Take a look at these 5 luxury hotels in London. They used to be secret spy locations in the past.
Are you going to Decorex in September? It's a major design event happening in London. If you are you need to start planning your stay.
As there are so many fancy hotels in London it might be a little hard to choose where to stay, to help you we are sharing this list of luxury hotels in London that not only are some of the fanciest but also have a rich background.
St. Ermin's Hotel
During the 50's, the hotel was the stage for secret encounters of the English intelligence and Russian spies. It used to be a safe house for informants and legend has it that there is a secret tunnel on the hotel's grounds. Besides, it looks incredibly luxurious!
Corinthia Hotel
This hotel was taken over by the British government during both World Wars and was a base for Winston Churchill. The secret tunnels the hotel had were filled in at the 2008 renovation that left this hotel looking modern! The luxury suites are worth a stay if you're in London.
Dukes Hotel
The bar of the hotel is legendary, as it was the birthplace of one of James Bond's most famous line. It's a hotel that will make you feel like a spy yourself and you'll be able to taste the Vesper, Bond's favorite.
See also: Secret Bars in London You Must Know About
The Royal Horseguards
Located very close to another hotel in this list, the Corinthia, this one was the home for the Secret Intelligence Service. It's full of classic spy elements that guests can see today, such as sliding bookshelves.
Millennium Hotel London Mayfair
This hotel is associated with espionage in our days. The late Russian spy Alexander Litvinenko was admitted to the hospital after having tea with two men, Later it was discovered he was poisoned with radiation. But don't be scared, as it's a luxury hotel worth staying in!
You might also like: Take a Look at the Most Popular Destinations on Airbnb Plus
source: architecturaldigest.com


text:
If you're looking for some wedding inspiration for your upcoming indoor wedding, my goodness, this has to be one of my favorites!! The Ebell of Long Beach will never disappoint in my opinion, it has to be one of my favorite venues of all time! From the sweetest first look, a gorgeous ceremony and reception set up, and the most wonderful bride and groom, this wedding holds a special place in my heart this year!
Planning and Coordination: Lucky Day Events
Videography: Boffo Films
Florals: Beautiful Savage Flowers
Venue: The Ebell of Long Beach


text:
Stand out at any occasion with the most impressive sound reactive LED mask made exclusively by Light Up Masks. This masks sound sensor syncs up to nearby noises, voices, or music to create a stunning light show!
Lightweight flexible material 0.3MM. Uses x2 AAA batteries (not included). Voice and music activated light that can be synced up to any song!
Designed, assembled, and shipped from Los Angeles, California.
I had a small issue with mask, this company immediately addressed my concern!
Never got it. I waited for a week and half and got an email saying that they were out and I had my money refunded. Now that being said I have had one of their masks before and loved it. So I ordered a different mask this time and should be getting it soon.
Sound Reactive LED Lighted Half Mask - X Ray Skeleton


text:
Hotel Construction Pipeline Up in the Middle East and Africa Remains Steady
STR's July 2019 hotel pipeline data showed 427 projects accounting for 123,742 rooms in construction in the Middle East and 138 projects and 25,986 rooms in construction in Africa.
The Middle East total represented a 2.1% year-over-year increase in the number of rooms in the final phase of the development pipeline. The region reported an additional 30,240 rooms in the final planning stage and 45,948 rooms in planning.
The Africa room construction total was down 1.8% year over year. Africa also showed 17,485 rooms in final planning and 23,954 rooms in planning.
Between the Middle East and Africa, four countries showed more than 4,000 rooms under construction. The United Arab Emirates led with 54,438 rooms, which represented 31.8% of the market's existing supply, followed by Saudi Arabia (41,207 rooms, 40.5% of existing supply).
- United Arab Emirates: 54,438 rooms (31.8%)
- Saudi Arabia: 41,207 rooms (40.5%)
- Qatar: 14,518 rooms (53.5%)
- Oman: 4,589 rooms (24.1%)
- Egypt: 4,100 rooms (2.4%)
STR provides clients from multiple market sectors with premium, global data benchmarking, analytics and marketplace insights. Founded in 1985, STR maintains a presence in 10 countries around the world with a corporate North American headquarters in Hendersonville, Tennessee, and an international headquarters in London, England. For more information, please visit str.com.
Logos, product and company names mentioned are the property of their respective owners.


text:
Connect with Schools
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Best Gene/genetic Therapy College in Rochester
We have created a 2020 ranking of the best colleges in Rochester that offer Gene/genetic Therapy degrees to help you find a school that fits your needs. Each school's ranking is based on the compilation of our data from reliable government sources, student surveys, college graduate interviews, and editorial review. In addition, you can view our entire list of all 1 Gene/genetic Therapy school located within Rochester. We also provide reviews, facts, and questions and answers for schools on our site and offer you access to get valuable information from colleges and universities today.
Best Gene/genetic Therapy Colleges in Rochester for 2020
|School Name
|Mayo Graduate School
|Rochester, MN
Mayo Graduate School offers 1 Gene/genetic Therapy Degree program. It's a private university in a mid sized city. In 2015, 3 students graduated in the study area of Gene/genetic Therapy with students earning 3 Doctoral degrees.
Read more: Mayo Graduate School Reviews
List of all Gene/genetic Therapy College in Rochester
|School Logo
|School Name
|Average tuition
|Student Teacher Ratio
|Enrolled Students
|Mayo Graduate School Rochester, MN
|3 : 1
Additional Gene/genetic Therapy Degree Facts for Rochester Schools
What Gene/genetic Therapy degree programs were earned in Rochester?
|Degree Level
|Program Length
|1-2 year Length
|1 Colleges
|3 Graduates


text:
Hello everyone,I have a small dataset (only 6 samples). Of those 6 samples, one of them is out of specification in regard to a Y-variable. I want to understand how much my X-variables are contributing to the sample being out of specification (if they indeed are) but I'm not sure what kind of analysis to perform on such a small data-set.Any ideas?Thank you so much!
Graph Builder...if you see anything that "looks interesting" then design an experiment (data collection plan) for gathering additional data to confirm or refute any "interesting findings" you found in your graph builder analysis of your 6 points.
To reinforce my former colleague @KarenC 's sage advice...all good analysis starts with what I call my three rules of successfull data analysis:
1. plot the data.
2. Plot The Data.
Can you share a bit more information about the practical problem at hand and the methodological approach to gathering the six observations? Is the response(s) numeric or categorical? Did you conduct a designed experiment? If so can you share the design? If not a DOE, then can you describe how the data was actually collected? What do you know about the measurement systems used for the responses? Were they in control and operating according to specifications? Maybe your one suspicious response is measurement system induced? Last thing you want to do is start making causal influences with an unknown or perhaps dysfunctional measurement system.
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Regular consumers of "Philippines Plus" know that I'm a crusty old expat. Sure, I could pretend that I never get irritated and that I'm always whistling "Zip-A-Dee-Doo-Dah." But sometimes that bluebird on my shoulder takes a crap. However, not today, O True Believers, for on this Sunday, October 15th, 2017, an 8-year goal has been realized. Yes, we are skipping Iloilo City and doing the bulk of our shopping on our island province of Guimaras. My asawa can now take our Aurora Blue Ford Ranger into the local market on our island province since our Governor and his Provincial Engineering Office took care of repairing our former muddy, rut-ridden road.
8-Year Goal Realized: Skipping Iloilo and Shopping Local
We're thankful for a tip from one of our local expat friends, a female Canuck who rarely cries"Eh?" We would still be riding the pump boat to nearby Iloilo City a couple or more times a month to do the bulk of our shopping if not for the Canadian. Our friend advised us several months ago that there was a local bank in Guimaras that had an ATM where we could withdraw our funds. We wouldn't have to go to Iloilo City anymore to extract our money.
Well, when I heard that I was happier than a drunk in a Red Horse warehouse. But it took a few months after that tip before I finally convinced my wife that we could do the bulk of our shopping in Guimaras. Basically, here was my argument:
1. We would save time. A round trip to our home from Iloilo City takes about three hours and that's only if you're doing something as simple as withdrawing money from an ATM. A shopping trip to Iloilo for us can start at 7:30 am and last until 5:30 pm when we arrive home.
2. We could save money. By doing our shopping in Guimaras we could save money on the following items:
That's an average savings of 1800 pesos, 35 US Dollars.
3. The Safety Factor. I feel much safer roaming around our island province than I do the big city of Iloilo which has over 400,000 inhabitants and much more crime. Plus, it takes a 15-minute pump boat ride to get to Ortiz Wharf in Iloilo. Sometimes the waves get a bit choppy. I can't swim. So when I finally convinced my asawa of over 17 years that we should do the bulk of our shopping in Guimaras, I was ecstatic.
The S&R Experience
While our shopping options are more limited in Guimaras, we can purchase the majority of the grocery items we need on our island province. During our monthly shopping trips to Iloilo we used to kick off our shopping expedition with a stop at the S&R Warehouse.
We would purchase two 20 kilo bags of dog food for our eight mutts at a cost of around 1,000 pesos each, 20 bucks. S&R is a member's only shopping outlet and offers a variety of food that we can't find anywhere else. However, we would drop 15,000 pesos (300 US Dollars) and up every time we shopped there.
Guess what? We discovered we can buy our dog food locally in Guimaras for the same price at "Hog Cocker's" (yeah, that's really its name and it's not a a porno palace for pigs.) In fact, our most pampered pooch, "Squeak-Squeak," loves the new chow. While we've found some good buys at S&R over the past year, many of the items we once purchased are now out of stock. Also, we discovered that a lot of the food stuffs we bought were very near the expiration dates.
So my spouse and I decided we didn't need to make a stop at S&R anymore. We're saving a ton of money. We survived the past seven years before the shopping club arrived and we'll manage without them.
Cost and Availability
While some items we used to purchase in Iloilo City are a few pesos cheaper than what we can get in Guimaras, the savings we acquire from doing our shopping locally don't justify shopping in the big city. Factor in the tremendous amount of time we save and it's not really not cost effective for us to go across the pond every month. Sure, we don't have any big shopping outlets like SM City but we've got Southern Trading.
I've head rumors for the past eight years that SM or Gaisano were going to build in Guimaras but thus far, that's all those reports are, rumors.
Regardless of that, the crusty old expat can stay at home now and save money to boot. I merely make a list and my loving, thoughtful wife merely purchases the items I request making life in "paradise" even better. Sometimes that bluebird on my shoulder doesn't take a dump!


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Another winning night for the #BlueJays affiliates as they took four out of six. Lansing and Vancouver had the night off.
Gwinnett 2 Buffalo 0
Sean Reid-Foley gave up runs in the first and second but pitched three shutout innings after that. He allowed four hits and two walks while striking out eight and getting five outs on the ground. Murphy Smith struck out four over three shutout innings of one-hit ball. Craig Breslow struck out one in one-third of an inning. Conor Fisk also whiffed one in two-thirds of a frame.
Vladimir Guerrero Jr. was 3-for-4 while Rowdy Tellez and Tim Lopes finished with two hits apiece. Dalton Pompey and Anthony Alford had the other base hits.
New Hampshire 8 Bowie 3
A bases-loaded double by Harold Ramirez and home runs by Gunnar Heidt and Andrew Guillotte led New Hampshire to victory. Ramirez and Bo Bichette had three-hit efforts while Heidt and Max Pentecost had two apiece. Jon Berti, Cavan Biggio and Forrest Wall also had a notch in the hit column with Biggio stealing a base. Only Santiago Espinal did not have a hit but he drew three walks.
Jon Harris gave up seven hits and two walks that led to three runs over five innings but he got the win. He struck out four and had five groundouts. Zach Jackson walked one and struck out two over two shutout innings. Corey Copping cobbled together two more shutout innings.
Daytona 9 Dunedin 8
Dunedin had a 3-0 lead and trailed 8-3 before coming up a run short. Riley Adams was 3-for-5 and Ivan Castillo was 2-for-6 with two RBI. Josh Palacios had a couple of base hits and a couple of bases on balls. Yeltsin Gudino was the only D-Jay not to get a hit but he did get a free pass.
Patrick Murphy gave up three runs on three hits and three walks and struck out four in 2-2/3 innings. Nick Hartman was hammered for five runs with1-2/3 innings on four hits and two walks with three strikeouts to take the loss. Claudio Custodio had one run on his ledger over 2-1/3 innings while Jake Fishman overcame a hit and a walk and struck out one over 1-1/3 scoreless innings.
Bluefield 9 Greeneville 5
A two-run double by Luis De Los Santos and an RBI single by Cal Stevenson started a five-run rally in the fifth to break this one open. Stevenson also clubbed a home run as part of a two-hit game and drew two walks. De Los Santos also had two hits and Gabriel Moreno had an RBI double among his two knocks.
Troy Watson got the win with five innings of two-run ball on five hits and a walk. His strikeout and groundout total were five apiece. Jackson Rees was rocked for three runs over two innings. Andy McGuire went two scoreless frames, offsetting a hit with a strikeout to collect the save.
GCL Blue Jays 11 GCL Phillies West 5
The Jays scored all of their runs in their final four at-bats. Yhordegny Kelly was 2-for-2 with a triple and an RBI after replacing Jordan Groshans who was 0-for-2 and was hit by a pitch. Joseph Reyes and Warnel Valdez also joined the two-hit parade. Adrian Ramos had a triple and three RBI.
Francisco Rios lasted 1-1/3 innings in his first outing since mid-May. He gave up three runs but only one of them was earned on a pair of walks and a hit by pitch. Williams Moreno and Juan Diaz were charged with a run in two-thirds and 3-2/3 innings respectively. The winner was Brayan Meijia after he contributed 2-1/3 innings of one-hit ball with a strikeout. Elixon Caballero finished up the ninth with a hit and a strikeout.
DSL Blue Jays 9 DSL White Sox 6
The Blue Jays scored nine times on just six hits but they walked 11 times. Pedro Hurtado had half the hit total with three. Jhon Solarte singled, walked and drove in two runs. Alberto Rodriguez also singled and walked and knocked home a run. Miguel Hiraldo was 1-for-5.
Ronald Govea was gonged for six runs on 10 innings over four innings with a K/BB total of 3-0. Junior Guzman gave up just three hits over five shutout innings and struck out one for the victory.
Griffin Conine was 1-for-2 with a double and Tanner Kirwer doubled in four trips to the plate to go with a stolen base. Cobi Johnson gave up two runs in his inning of work.
*** 3 Stars!!! ***
3. Vladimir Guerrero Jr., Buffalo
2. Sean Reid-Foley, Buffalo
1. Harold Ramirez, New Hampshire


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Availability date:
For the treatment of menstrual cycle disorders and pre-menstrual syndrome symptoms
Package leaflet: information for the user
Agnufem 20 mg film-coated tablets
Dry extract of chaste tree fruit
Read all the information in this leaflet carefully before you start taking this medicinal product because it contains important information for you.
Always take this medicine exactly as described in this leaflet or as directed by your doctor or pharmacist.
Keep this leaflet; you may need to read it again.
If you have any further questions, ask a pharmacist.
If you experience any side effects (even if it is not listed in this leaflet), consult your doctor or a pharmacist.
If your condition did not improve within 20–30 days or even worsened, contact your doctor.
What is in this leaflet?
1. What Agnufem is and what it is used for?
2. What do you need to know before you use Agnufem?
3. How to use Agnufem?
4. Possible side effects
5. How to store Agnufem?
6. Contents of the package and other information.
1. What Agnufem is and what it is used for?
Agnufem's active substance is chaste tree (Vitex agnus-castus L.) fruit dry extract.
Agnufem is used to relieve pre-menstrual syndrome ailments. These ailments include irritability, tension, mood swings, breast tenderness and painful spasms.
2. What do you need to know before you use Agnufem?
Do not use Agnufem:
If you are allergic (hypersensitive) to the active substance or any excipient of Agnufem;
If your medical history shows that there have been or still are symptoms of pituitary gland disorder;
if you are pregnant or breastfeeding;
if you are younger than 18 years of age.
Take special care with Agnufem:
If you had or have oestrogen-dependent tumours, consult your doctor before taking Agnufem.
Patients should consult their doctor before taking Agnufem if they take dopamine receptor agonists and antagonists, oestrogens and anti-oestrogens (see chapter 4.5).
It is not recommended for use in children and adolescents under 18 years of age because there is insufficient data in this group of patients.
If the symptoms worsen while taking Agnufem, consult your doctor or a pharmacist.
It is believed that chaste tree fruit extract affects the function of the hypothalamus-pituitary gland; therefore, patients with pituitary gland disorders should consult their doctor before taking this medication.
In the case of prolactin-releasing pituitary tumours, the use of chaste tree fruit extract can hide tumour-induced symptoms.
Other medicines
When Agnufem is used in combination with dopamine receptor agonists and antagonists, oestrogen and antioestrogens, the effect of both medicinal products may be reduced.
Pregnancy and breastfeeding
Before taking any medicine, you must consult your doctor or a pharmacist.
It is purposeless to take Agnufem during pregnancy.
You must not take Agnufem if you are breastfeeding because this can reduce the amount of milk.
Chaste tree fruit extract reduces the amount of luteinising hormone through the dopaminergic system. This can have a negative effect on fertility.
Driving and using machines
Agnufem does not influence the ability to drive and use machines.
Important information on some excipients of Agnufem.
3. How to use Agnufem?
Always use this medicine exactly as directed by your doctor. If in doubt, consult your doctor or a pharmacist.
For adult women
It is recommended to take 1 tablet a day, with liquid.
It is recommended to take the tablets for at least 3 months, without interruptions, during menstruation as well.
If you feel that the effect of Agnufem is too strong or too weak, consult your doctor or a pharmacist.
If you take more Agnufem than you should
In the event of an accidental overdose, consult your doctor or the nearest hospital emergency department.
If you forget to take Agnufem
Do not take a double dose to make up for a forgotten dose.
If you stop using Agnufem
Not determined
If you have any further questions on the use of this medicinal product, consult your doctor or a pharmacist.
4. Possible side effects.
Agnufem, like all medicinal products, can cause side effects, although not everybody experiences them.
Serious allergic reactions may occur: facial swelling, trouble swallowing or breathing. Skin allergies (itching and hives), headache, dizziness, digestive disorders (nausea, abdominal pain), acne and menstrual disorder have been reported. The frequency is unknown.
Reporting of side effects
If you experience any side effects, including those not indicated in this leaflet, tell your doctor or a pharmacist. You can also report a side effect directly, via the form on www.vvkt.lt website, by mail to the State Medicines Control Agency under the Ministry of Health of the Republic of Lithuania, Žirmūnų str. 139A, LT 09120 Vilnius, phone: 8 800 73568, fax: 8 800 20131 or via email: firstname.lastname@example.com. By reporting a side effect, you can help us get more information about the safety of this medicinal product.
5. How to store Agnufem?
Keep out of reach and sight of children.
This medicinal product does not require any special storage conditions.
Do not use this medicinal product after the expiry date stated on the carton and blister pack. This medicinal product is suitable for use until the last day of the indicated month.
Medicinal products should not be disposed to drainage or with household waste. Ask a pharmacist how to dispose of unnecessary medicinal products. These measures will help protect the environment.
6. Contents of the package and other information.
Agnufem composition
- The active substance is dry extract of chaste tree fruit.
Each film-coated tablet contains 20 mg of Vitex agnus-castus L., fructus (chaste tree fruit) dry extract (6-8:1).
Extraction solvent: 75 % (V/V) ethanol.
- Excipients. The core of the tablet contains calcium hydrogen phosphate dihydrate, microcrystalline cellulose, copovidone, croscarmellose sodium, stearic acid, magnesium stearate, anhydrous colloidal silicon dioxide. The coating of the tablet contains hypromellose 606, hypromellose 615, talc, macrogol 6000, titanium dioxide (E171).
Agnufem appearance and amount in the pack
Agnufem film-coated tablets are white or almost white, round, convex, with a diameter of 11 mm.
Agnufem is packed in blister packs of 20 tablets. Blister packs are packed in cartons of 20, 40, 60, 80 or 100 tablets.
Not all package sizes might be available.
Manufacturer: UAB Aconitum, Inovaciju str. 4, Biruliskes village, Kaunas district, Lithuania


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Q. I would like to know the proper method for storing fresh garlic - in the refrigerator or out?
A. Store whole garlic heads in a cool, dark, well-ventilated place in a container that lets air circulate, such as a mesh bag. The garlic should keep for up to one month.
There are two reasons why you shouldn't store garlic in the refrigerator, says Marita Cantwell, post-harvest specialist at the University of California at Davis. The strong odor of garlic can be absorbed by other foods in the refrigerator. Secondly, superficial mold growth will develop on the papery skin of the garlic when it is stored in a damp environment such as a refrigerator (where relative humidity ranges from 85 percent to 90 percent).
When buying garlic, choose heads that are full, smooth and firm, without green sprouts. Cantwell says that the green sprouts indicate moisture loss and cloves that are more pungent.
Peeled or chopped garlic should be refrigerated in an airtight container to prevent the transfer of odors. Use it as soon as possible.
RAEANNE SARAZEN, Chicago Tribune


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By: Dee Jason
AVP, Branch Manager, NMLS #662874
Sean Daniel Nation found plenty to do as a Riverton High School senior. He was in Hawk Pride, Spanish Club, Engineering Club, Hawk 101, on the Math Team, and WYSE. He ran cross country and played baseball all four years of high school and served four years as stage crew manager. Prior to senior year he played basketball, was on the golf team and participated in Scholastic Bowl. All of this helped him earn the school's April Student of the Month Award, a recognition sponsored by Illinois National Bank (INB).
Because of his many activities and academic success, Nation has earned a number of other awards and recognitions. They include: IHSA Scholar Athlete, National Honor Society member, National Technical Honor Society member, Southern Illinois University-Carbondale (SIU-C) Honors Program, Socrates Award, three-time student of the month, and a varsity letter winner in cross country, baseball, basketball and golf.
Nation plans to attend SIU-C to study computer engineering.
Russ and Wendy Nation are his parents. He was chosen for the Student of the Month Award by the staff and faculty of RHS based on attendance, academics, effort, conduct, cooperation, dependability, leadership, school involvement, and service to others. He received $25 from INB and was eligible for 2014-2015 Student of the Year honors at graduation.
You are leaving INB's website. INB is not responsible for the content of
the linked site. Please be advised that you will no longer be subject to, or under the protection of, the privacy
and security policies of our website. We encourage you to read and evaluate the privacy and security policies of
the linked site, which may be different than ours. Please confirm that you would like to continue.


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In any city in the United States today, technology is doing human work. In many instances, that's a good thing. As a single mother of two, I'm grateful that I can order groceries, work from home, deposit a payment, connect with an old friend, and check my recent blood test results, all without leaving my home. Technology saves me time. It saves me energy. But if I'm being honest, it also makes me lonely.
I'm not the only one who feels this way. Many agree that loneliness has become an epidemic in our society—so much so that scientists are working to create a pill to cure it. As recently as last year, academics from Brigham Young University noted that advancing social connectedness should be elevated to a public health priority in the United States due to its impact on health and mortality. Isolation is not an aging issue. It's an everyone issue. That's why it's so important to understand the ramifications of using technology to solve it.
In a time when the number of aging Americans is skyrocketing, and the number of people willing or able to care for them is declining, technology offers a tempting alternative to human care. But technology alone won't solve isolation and loneliness in aging. Unless we begin to reframe both how we use it, and who we involve in developing it, technology could even exacerbate the problem.
The anti-aging industry is expected to hit a value of $55 billion+ by 2023. To many of us, aging signifies decreased physical ability, a loss of beauty, and a lack of purpose. It's something we want to avoid at any cost. Sadly, our stigmatization of aging has spilled over into the development of assistive technology and robots for aging people.
In a recent study, "Reframing Assistive Robots to Promote Successful Aging," Dr. Laurel Riek, professor of Computer Science and Emergency Medicine, UC San Diego, and her team found that even the concept of assistive technology represents a deficit model of aging. Some develop companion robots to shoulder the burden of aging people—to privatize, rather than prevent, loneliness.
Just as importantly: older people recognize this. Riek's research showed that while assistive robots have been developed for decades, older people have rarely chosen to adopt them in their real lives, in part because they are hard to use, and also because they focus on disability, rather than successful aging. Amanda Lazar, assistant professor in the College of Information Studies at the University of Maryland, agrees.
"The technology events on aging I have been to can skew very young," she says. "The technology is designed by younger people, for younger people—their eyes, their brains, their fingers, their life experiences—so there should be no surprise if the things that are created are difficult to use or don't meet the needs of older people."
Paul Nussbaum, Ph.D., a board-certified clinical and geropsychologist focused on brain health in aging, suggests there may be another, even more obvious reason for low robot adoption.
"Human interaction is biologically important," Nussbaum says. "In the next 40-50 years we may find humans willing to have technology and robots lead or control most of our primary daily activities and interactions. In the meantime, it's just not the same."
Using technology as a replacement for human interaction may be convenient, but it isn't healthy or desired by today's aging Americans. We need to start thinking of technology as a way to increase human interaction, rather than merely a way to prevent loneliness in aging people.
When we think of using technology to end social isolation, it's easy to get stuck on the concept of care-bots and telehealth services. However, developing the right technology for caregivers, clinicians, policymakers and even insurers can also go a long way in preventing social isolation in older people by freeing up more time for them to make human connections.
"Technology that allows nurses to be nurses, that allows clinicians to be clinicians—these are the types of things that can increase human touch," Nussbaum says.
On the healthcare side, there's AI to help process paperwork and other mundane tasks on the part of doctors and nurses. These types of technologies can increase the quality of human interaction between caregivers and their loved ones, as well. For instance, technology like Answerbot and GI Joe Robot can help relieve the stress of caring for those struggling with dementia. Answerbot will do the stressful work of answering repetitive questions and redirecting conversation. Other technologies have further helped to reduce the stress of caregivers by "playing the bad guy" in limiting the intake of certain foods, mandating physical activity, or requiring a caregivee to take his or her medication. Even apps like Instacart and Shipt do well in relieving the stress of shopping for groceries while trying to care for someone we love. This in turn allows the caregiver to engage in more meaningful and enjoyable social interaction and relationship with the caregivee overall—a much higher goal.
Sometimes technology can be used to bring older adults together, and a few projects have had success in this regard, Riek says. This can include connections to existing family members and friends (e.g., Skype), social networking, companion robotic pets, etc. Technology can also be a lifeline for those living in isolated areas.
"It's not so much the technology itself, but how it's used," she shared with me. "If a health system decides to replace healthcare worker home visits with telehealth consultations, it removes human contact from someone. In addition to the social benefits the older adult receives from the visit, the healthcare worker may notice things around the house which affect a person's health (e.g., a rug that is a tripping hazard, the presence of fruit and vegetables, etc). However, there are many people across the world who don't receive any care, and a telehealth consultation is far better than nothing."
Nussbaum agrees. Especially in rural areas, a telehealth consultation could be the difference between at least some digitalized human interaction and no human interaction at all.
Still, despite huge advances in the personalization of artificial intelligence, there is no technology that can replace human touch, smell, warmth, or even human kindness. And, it shouldn't try to. The gold standard should always remain human interaction. By developing technology hand in hand with older people, we will go much further in reaching the ultimate goal: not merely a reduction in social isolation, but a model for successful aging overall.
Stria sponsors GrandPad and Home Instead made "The Role of Technology in Social Isolation" special editorial series possible.


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1. Tonight I saw a lot of lightning. (Actually it was last night, lol)
2. Any song with a really good beat makes me wanna dance!
3. Splitting a few appetizers between friends always makes for a great time!
4. My childhood best friend who I lost touch with is someone I'd like to get to know better.
5. The smell of rain reminds me so much of springtime!
6. He smiled and that made it all better.
7. And as for the weekend, tonight I'm looking forward to packing, tomorrow my plans include Tanya's wedding and Sunday, I want to move some stuff to our new place!


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Search AAIHDS Site:
Career Center
Janssen is currently recruiting for two Commercial Disease Area Strategy (DAS) Leaders, Vaccines.
The Commercial DAS Leaders will be accountable for leading Janssen Global Commercial Strategy in their respective vaccines' areas. Core areas of responsibility include:
These roles will serve a critical leadership function on the GCSO Infectious Disease and Vaccines Leadership Team. The position reports directly to the Global Commercial Strategy Leader, Infectious Disease and Vaccines.
A minimum of 10 years of pharmaceutical commercial or relevant experience is required. The successful candidate will have demonstrated a strong track record of success in the following areas:
Click here to apply!


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When you're running a health and wellness business, you need to focus on the daily operations of your company instead of trying to do everything on your own. Your top priorities likely include keeping your customers satisfied, as well as growing your company. You probably don't have time to manage the accounts receivable aspect of your business. However, in order to secure the cash flow you need to operate smoothly, you must stay on top of your accounts receivable.
How Outsourcing Can Help
By outsourcing to a reputable U.S. company (like us), you can get the billing services you need performed by a team of experts. Why should you do this? Consider the following reasons:
- No Time: You are a small health and wellness company, and you don't have the time to do the billing yourself.
- Limited Resources: You are a business of small or medium size, and your staff resources are limited. You can't afford to hire internal personnel solely for the purpose of managing your accounts receivable.
- You Aren't Being Paid on Time: While it isn't unusual for some customers to pay late, you can't afford to have all of your clients do this. If you have trouble keeping track of which clients currently owe your business, your company is probably losing money.
Hiring Experts Leads to Quality Results
You need to focus on your business. You can't grow your company if you are trying to do all of the administration and accounting tasks yourself. Managing accounts receivable requires a significant amount of time, effort, and specialized knowledge. You must delegate some of these tasks to professionals who are trained to do them.
We will read the details of your client contracts and bill according to the specific terms. We bill directly to your customers, and we make sure this is always done accurately and in a timely manner. Don't allow your invoices to go unsent or unpaid due to lack of time and resources. We eliminate the stress of handling your accounts. You are then free to remain focused on the success of your health and wellness company. Contact us today, so we can provide your business with solutions.


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A few days ago, we had the opportunity to supply the podium autocue for a large private international event that was held in Jebel Ali, Dubai. Six top executives of the international firm were in Dubai for the one-day event and they all had to address the audience.
The speakers wanted a podium prompter to help them present their speeches without the stress of having to remember lines, keep looking at their notes or worrying about fumbling during the presentation. They wanted to speak 'naturally and effortlessly' and accurately.
We were approached by the event organizers who were a trifle nervous as they had never supplied autocues for events and were not familiar with the workings of it. More people are now asking for the podium prompters for use at public events.
We reassured them and explained how we go about setting up the podium autocue and how we even coach new users on how to take advantage of these highly effective public speaking aids. They were happy to get a solution for the challenge. Their confidence was further boosted when their clients affirmed that what we have explained and shown them is what they were looking for and needed.
We had a rehearsal the day before the event which went well. Moviemedia crew was, as usual, at the venue before the call time, the technician waited patiently for the podium to be built up before he could set up the podium autocue and the operator loaded all the speeches promptly and professionally onto the podium autocue software. Changes for all the speeches were made on-site as required.
Next day, the day of the event, the executives walked up to the stage one after the other and addressed the audience in a very convincing fashion.
Naturally these speakers had unique requirements in their delivery style and pacing of their speeches. Speakers come in different heights (I am talking of people here!) and this was an important aspect our team meticulously took into consideration. All these factors play an important part in setting up a podium prompter. The event went off like clock work and all the speakers were happy that our operator worked the autocue to their utmost satisfaction.
These podium teleprompters are also referred to as a podium autocue, stage prompter and presidential prompter after President Obama was seen to use them on a regular basis.
Contact us today for your prompting needs in the Dubai, Abu Dhabi or anywhere in the United Arab Emirates (UAE). We can also travel to other countries should the need arise.
If it is your first time to deal with such a requirement, don't worry, our team of experts will take you through the process efficiently and we believe you and the stakeholders of the event will be fully satisfied with the results.
Contact us on email@example.com, +971 4 268 3873.
Moviemedia is a reputed supplier of the podium autocue and camera-mount teleprompter in Dubai, UAE.


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Almost two years after UCLA unveiled $136 million renovations to Pauley Pavilion, the school is going to have to put more money aside to restore the legendary basketball arena.
The court which saw future Pro Basketball Hall Of Famers such as Bill Walton and the former Lew Alcindor (Kareem Abdul-Jabbar) suit up for the Bruins suffered a horrible defeat Tuesday afternoon.
Per Yahoo Sports, the water main ruptured at roughly 3:30 p.m., flooding Sunset Boulevard and several campus parking facilities.
Los Angeles Mayor Eric Garcetti told reporters the pipe involved was from 1921 and could not be shut off immediately to prevent further damage to the system.
The timing of the water main break is not ideal for a state already in the midst of a drought.
California had already implemented emergency water-conservation measures earlier Tuesday that included fines of up to $500 per day for using a hose to clean a sidewalk or other wasteful behaviors.
Social Media:
Follow Eugene Evans on Twitter @GenoSportsguy.


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Fennel Microgreens / Microherb Seeds
Fennel Seeds: Foeniculum vulgare
Seeding: Approx 1 Oz for a 10x20 inch tray
Seed Presoak: No
Growing Medium: hydroponic, soil
Preferred Medium: soil
Germination Rate: high
Germination Time: 3 to 4 days
Microgreens Harvest time: 12+ days
Microgreens Ideal Harvest: 12+ days
Baby Salad / Adult Stage Harvest: not recommended
Micro Greens Color: green
Micro Greens Flavor: Mild, anise flavor
Learn More
- 2 g - Approximately 2,000 Seeds
- 1 oz- Approximately 34,000 Seeds
- 4 oz - Approximately 136,000 Seeds
- 1 lb - Approximately 544,000 Seeds
- 5 lb - Approximately 2,720,000 Seeds
- 25 lb - Approximately 13,600,000 Seeds
- Microgreens
- Garnishes & sandwiches
- Herb Gardening
- Cooking & seasoning
- More
Notes & Growing Tips: Fennel is an herb in the celery family that is popular as a garnish. Because it's anise flavor is so mild, it makes a great choice as a garnish for a wide variety of dishes from sweet to savory. It can be grown hydroponically but it is tough to do. You will likely have a much easier time growing micro-fennel in soil. Sow seeds a little more thinly and give your plants room to grow. Fennel seed husks can be stubborn in clinging to leaves, so plan on growing long enough for most to drop. Micro fennel seeds for microgreens.


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Inventek Systems and Ayla Networks announce a 2.4G IoT Design Kit with Inventek Systems' ISM43362-M3G-L44-E/U Embedded Serial-to-WiFi Module, ISM43362-M3G-L44-E/U Embedded Serial-to-WiFi Module | Inventek Systems
The Inventek-Ayla Design Kit gives you out-of-the-box cloud connectivity. Forget about socket programming — there's no need to develop any networking code or learn how to provision a cloud service! Just fire up the included STMicroelectronics STM32F3 and start building a cloud-connected product. Or use the onboard prototyping headers to connect the kit to another microcontroller or directly to an existing product and prototype a connected product in days.
The Inventek ISM43362-M3G-L44 Wi-Fi module requires no operating system and has an integrated TCP/IP stack that only requires a simple AT command set to establish connectivity for your wireless product. The module has a very small 14.5mm x 30mm surface mount footprint and has full FCC and CE module certification. This product is targeted for low cost embedded wireless applications and enables a quick, easy and cost effective method adding WiFi connectivity to your platforms.
A summary of the key module features:
- 802.11 b/g/n Compatible based on Broadcom MAC/Baseband/Radio device.
- Fully contained TCP/IP stack thus minimizing host CPU requirements
- Configurable though AT commands.
- Host interface: USB, UART, SPI up to 25 MHz
- Network features ICMP ( Ping), ARP, DHCP,TCP, UDP
- Low power operation (3.3V supply) with built-in low power modes.
- Secure WiFi authentication WEP-128, WPA-PSK (TKIP), WPA2-PSK
Purchasers of the Inventek-Ayla Design Kit get access to microcontroller driver source (typically 5-20KB), demo applications and Inventek-Ayla Application Libraries, which enable you to create great apps that securely control your Inventek-Ayla enabled devices with a smartphone or tablet. Supporting Android, iOS and web interfaces, you can focus on your UI and leave the networking, security and authentication to us. Inventek's proprietary IWIN (Inventek Wireless Interoperability Network), firmware also provides our customers a very compelling and user friendly protocol to ensure maximum optimization and seamless integration of WICED.
With the Inventek-Ayla Design Kit, you'll get an account on Ayla's Developer Portal — a simple UI-driven design allows you to build or modify templates for your products in just minutes. Just sign up for a developer account, define a new template, and when you use the same named properties in your design, Inventek-Ayla will take care of connecting the device and the cloud and keeping them in sync.
The Inventek-Ayla Design Kit will also give you access to Inventek's and Ayla's support site, which contains the documentation and how-to guides you'll need for your product development, from porting guides for SPI drivers to documentation on connecting to other cloud services through our RESTful APIs. You can also sign up for a support package that meets your needs.
2 Republic Road
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The Jakarta Post
A stock image pairs a brand-new white sneaker with the same sneaker after some wear and tear. (Shutterstock/xveron90x)
Most of us don't think twice about throwing out a pair of shoes that have become scuffed and off-color, but not Gucci: The high-end fashion label has just launched a pair of stained, scuffed leather sneakers for US$870.
The Italian label has said that the sneakers give off a "vintage, distressed effect" with their off-white and dirty-looking aesthetics, which was "influenced by classic trainers from the 70's", reports Insider.
The Gucci website's description for the footwear reads: "A pastiche of different influences that span across decades, the Cruise 2019 collection references old school shapes and materials inspired by vintage sportswear."
According to Insider, the distressed sneakers, which have been dubbed "Screener" for "screen", a sports term referring to a blocking move, "features the Web stripe on the side and the vintage Gucci logo".
Read also: Youngsters fork out for snazzy sneakers
In contrast, a similar pair of non-distressed Gucci sneakers costs $580, so some wear and tear would likely achieve the same "used" effect – and for a lower price tag.
This isn't the first time Gucci has put a premium price tag on a pair of dirty-looking sneakers. It has marketed its Rhyton leather sneaker as having a "retro influence" in its specially treated leather, which has a similar "vintage, distressed effect". (geo/mut)
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