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May 2018
Considerations for the Near Future of Drug Delivery Devices Below the Knee
A global panel of limb salvage experts weighs in on the promise and pitfalls facing adoption of drug-based options.
With Marianne Brodmann, MD; Antonio Micari, MD, PhD; Jihad A. Mustapha, MD, FACC, FSCAI; and Ramon L. Varcoe, MBBS, MS, FRACS, PhD
How do your expectations for both short- and long-term outcomes for drug delivery devices below the knee (BTK) differ versus those in the superficial femoral artery (SFA), if at all?
Prof. Brodmann: For some time now, drug delivery has become standard of care for SFA/popliteal artery treatment; however, for BTK disease, we are still fighting for evidence. It is true that some drug-coated balloons (DCBs) are available and approved for use in BTK arteries, but the usage in everyday practice is reduced to a minor subset of patients, mainly those with a high rate of restenosis.
Dr. Varcoe: Treatment of peripheral artery disease (PAD) BTK is usually reserved for patients with critical limb ischemia (CLI), whereas most isolated SFA lesions are treated because of claudication. These two conditions are associated with very different treatment goals. In most cases, the goal of treating BTK lesions is to achieve ulcer healing and limb salvage, which is usually accomplished over the short to mid term. However, when treating the SFA, the goal is long-term symptom relief with associated ongoing improvements in quality of life.
The purpose of adding antiproliferative drug to angioplasty balloons and stents is to improve the patency of the intervention and reduce the need for target lesion revascularization (TLR). Although those two things are closely linked in the SFA, it is unusual for BTK patency loss to result in recurrent ulceration and the need for TLR. Therefore, patency itself may have little impact on limb salvage outcomes from long-segment BTK disease. In saying that, even though durability is less important BTK, if there were two options with one more durable than the other, it is that option that will be chosen every time.
Dr. Micari: First, we need to understand and learn how to use the drug delivery devices in the BTK setting. Elution itself is not straightforward due to calcification, sizing, and deliverability of the device. Only after understanding these issues will we obtain results similar to those found in the SFA.
Dr. Mustapha: Some of the pitfalls in the early trials of the SFA led to improved approaches to drug delivery to the SFA and popliteal artery, including the need for vessel preparation, appropriate balloon-to-vessel ratio sizing, adherence to the time transition of the DCB to the target lesion in a timely fashion, immediate balloon inflation, and maintaining balloon inflation for at least 2 minutes. Also, physicians and industry were misdirected by some of the preclinical work, as decisions were made under the belief that infrainguinal arteries are similar to the coronary arteries.
How would you describe your expectations for the performance of a DCB BTK versus standard percutaneous transluminal angioplasty (PTA)? How long do you expect the treatment benefit for a DCB versus standard PTA to last?
Dr. Varcoe: For a DCB to be useful, it should safely improve patency rates and reduce the need for TLR compared with PTA alone. Ultimately, I would like to see a reduction in major amputation rates for DCB, as that is the most important endpoint for the treatment of CLI. To date, there is no convincing evidence that any DCB can achieve that goal1,2; however, if future efficacy were to be demonstrated, I would want to see that benefit last at least 12 months for its use to be justified.
Dr. Mustapha: The science has not yet answered this question completely. We have had multiple failed DCB BTK trials, but that should not lead us to the conclusion that DCBs do not work in the BTK arteries. Again, the misleading comparison of anatomic similarities between coronary arteries and tibial arteries played a major role in the failure of the BTK trials. We now know that tibial arteries are significantly different from the coronary arteries in their anatomic and pathologic disease variation. With this knowledge, our approach is changing.
In ongoing trials, we now ensure that the DCB is used in the tibials only after the target tibial lesion is well prepared to receive the drug first to its endothelial lining, then crossing the subendothelial layer followed with the barrier of the internal elastic tissue, then into the media and possibly the adventitia. This might sound like a simple process, but in reality, most tibial arteries that require therapy tend to be heavily diseased with unwanted intimal and medial calcification, neointimal hyperplasia, and thickening of the elastic lamina, both internally and externally. A good example is shown in Figure 1, where the drug and its excipient have to travel across tremendous barriers to reach the source where neointimal hyperplasia must be inhibited.
Current DCBs must be appropriately sized in the tibial arteries to maximize the highest rate of drug transfer from the balloon surface to the tibial endothelial wall to then make the journey to the media and beyond. I believe that if we do it correctly, the result of DCBs in BTK arteries would result in sufficient neointimal inhibition by the antiproliferative mechanism. At the same time, I also believe that we need more of a mechanical component added to the drug/excipient component so we can create an equal ground for all operators and all excipients to consistently reach the media and beyond at the end of the procedure.
In my experience, BTK PTA has been very poor. PTA is the most commonly used treatment modality in the BTK arteries, yet the data over the last 30 years, including the latest large meta-analysis, show extremely high recoil and restenosis rate post-PTA.3 Hence, I hesitate to use PTA alone during tibial interventions, and my hope is to see DCBs approved and available in the United States, given that 3 decades of data have shown that PTA alone is associated with extremely high restenosis rates.4-6
Prof. Brodmann: My expectations are, for sure, a lower rate of restenosis, as impaired flow is a main contributor to CLI. Longer primary patency would result in fewer reinterventions, which would be a huge benefit in this CLI patient cohort. If we were able to achieve sustained patency up to 12 months, this would be very beneficial.
Dr. Micari: Most reocclusions related to standard PTA occur in the first 3 months after the procedure. I expect that DCBs will provide longer patency, and even in the case of loss of patency, we will appreciate focal restenosis or reocclusion and not full-length reocclusions.
Which factors will most affect your decision to choose a drug delivery device rather than standard PTA?
Dr. Mustapha: Data will affect my decision. Although much of the successful DCB data have been single-center studies or series, at least DCBs showed significant benefit over PTA alone.
Dr. Micari: To change standard practice, we need to have evidence-based data. Different trials are being run to determine the superiority of DCB versus PTA. After compiling the results, we should offer our patients the best treatment based on the data.
Prof. Brodmann: If there were evidence that a DCB works BTK, I would be happy to apply the same protocol as I do for the SFA/popliteal artery: adequate vessel preparation, which is even more relevant BTK than above the knee, and then application of a DCB.
Dr. Varcoe: Thus far, the only drug delivery devices that are shown to be effective BTK are drug-eluting stents (DESs).7-9 These are coronary devices that currently have lengths up to 48 mm. Therefore, they are only of practical use in short- to moderate-length lesions and seem to be well matched to arteries found in the mid to proximal calf.
Are there cases in which the potential for adverse events due to distal particulate embolization will preclude you from selecting a DCB?
Dr. Varcoe: No, but I am unlikely to choose a DCB for crural PAD in the absence of evidence that it is more effective than PTA.
Dr. Mustapha: Yes, I would not recommend use of DCB in cases where circumferential intimal and medial calcification are not modifiable when concentric neointimal hyperplasia does not respond to high-pressure balloon angioplasty (Figure 2).
Prof. Brodmann: Yes, if I know that the DCB I have in my hands is not the newest and safest technology with regard to the drug formulation or coating technique, I would not use it.
What percentage of your BTK cases do you estimate will require vessel preparation of some kind before drug delivery? What distinguishes these cases?
Prof. Brodmann: In my opinion, we should focus more on adequate vessel preparation in any patient we are treating with a DCB, independent from the anatomic area.
Dr. Micari: Vessel preparation BTK is crucial. I do not think we can use a DCB without vessel preparation. It is still unknown as to what type of device is best, and we probably we need to tailor our vessel prep for different situations. However, I use DCBs only after appropriate preparation of the vessel and I try to size 1:1.1 vessel/DCB ratio to be confident that I am touching the vessel wall to best elute the paclitaxel.
Dr. Mustapha: All tibial cases require vessel preparation prior to DCB delivery. The distinguishing factor is the element of the presence of concentric disease combined with elastocalcinosis and intimal and medial calcification.
Dr. Varcoe: Most lesions will require predilatation with simple PTA prior to the application of a drug delivery device, whether that device is a DCB, DES, or an adventitial delivery system. However, the question of which lesions would benefit from the use of specialty balloons and atherectomy is more contentious. Some evidence suggests that specialty balloons may result in less flow-limiting dissection and thus reduce the need for the use of a permanent metallic implant.10 The same may also be true of atherectomy; however, the evidence to support these technologies in BTK vessels is sparse.11,12
How might the post-2017 reimbursement situation for DCBs in the United States affect their uptake even once approved by the US Food and Drug Administration?
Dr. Mustapha: This is a tough question. I can't deny the disappointment with the seemingly rash decision to not reimburse DCBs, which is resulting in diminishing use. Let's not discuss our personal opinions or feelings about the Centers for Medicare & Medicaid Services (CMS) decision, but rather let's discuss the science that for the first time showed excellent long-term results for some of the sickest patients we treat. None of us can guarantee how much DCBs will be used without reimbursement in hospital and nonhospital settings. Like many others, I cannot understand why CMS would take away a scientifically proven, effective treatment from patients who need it. In all the DCB trials, one common theme was noted—less repeated endovascular procedures when DCBs were utilized. This can translate into many different patient-centric benefits that were stripped away from the patients, with the most important on my list being quality of life and work productivity.
Dr. Micari: It is difficult to say. To be sure, economic issues should not affect the best treatment for patients, but it is the real world, and I regret to say that reimbursement is necessary to help device penetration in the market.
Although similar in size, we have learned of substantial distinctions between the coronary arteries—where DESs are approved for use—and the BTK vessels. What role do you believe these devices currently play (ie, which vessels and nature of disease)?
Prof. Brodmann: There are only limited data on this specific point. So far, we have promising data with regard to short DESs in BTK disease, but on the other hand, we all know how extensively BTK arteries are diseased—we are talking about 3- X 30-cm-long, heavily diseased, thin arteries (2–4 mm in diameter). So, a general DES approach as applied in coronary disease is, in my opinion, not useful and/or possible. There are perhaps some situations in which a short DES might make sense.
Dr. Micari: At the moment, DESs have a very small role and are only used in selected short and calcified lesions. Routine use is not likely.
Dr. Varcoe: The use of coronary DESs in BTK arteries has been approved in Australia for close to 10 years. I am liberal in my application of these devices and have seen excellent results, similar to the body of evidence from randomized trials. I choose to use them in short- to medium-length lesions (< 10 cm) and try to avoid them in arteries < 2.75 mm. I also use them to improve runoff after treating the SFA, when I encounter a discreet, proximal tibial lesion. That practice is not supported by evidence but follows the surgical principles of bypass patency relying on good inflow and outflow. In my view, it is a sound extension of that same principle for SFA revascularization.
Dr. Mustapha: Coronary-based DES platforms are best in the proximal tibial arteries. Many trials have shown the benefits. The issue is that current coronary balloon-expandable DESs are not effective beyond the proximal tibial arteries. They tend to crush and fracture with severe hyperplastic restenosis.
What do we most need to learn in a trial setting about the performance and expectations of DESs BTK before we know if these devices are ready for prime time?
Dr. Mustapha: To start with balloon-expandable DESs, we have had multiple trials, and the conclusion was clear about their positive impact in proximal tibial arteries. Beyond the proximal tibials, we must shift into self-expanding and long DESs to address the multifactorial causes that lead to the failure of balloon-expandable DESs. The type of stent we need for BTK arterial disease is very complex; we need self-expanding stents with strong radial force plus long-term drug emission, the ability to conform to the tapering aspect of the tibial arteries, and fracture resistance.
Dr. Varcoe: We have long-term data for DESs to attest to their safety BTK. We also have level 1 evidence to attest to their efficacy.7,9 They have been shown to reduce restenosis, clinically driven TLR, contribute to sustained improvement in Rutherford class, and avoid major amputation compared to conventional endovascular therapy.7-9 We have small data sets that suggest that DESs perform poorly at bifurcations around the ankle and foot.13,14 These devices are great for a certain subset of lesions, but they are not suitable for long chronic total occlusions, which are more frequently encountered in CLI.
Dr. Micari: First, we need to see if DESs can be effective in the real CLI disease anatomy. A 40-mm stent cannot be a solution for 40-cm occlusion!
Prof. Brodmann: We have to identify specific lesions and patients in which and in whom a DES makes sense, as BTK disease is so extensive.
Based on the current understanding of the differences between the coronaries and tibials, what anatomy-/disease-specific enhancements would you like to see in both stent and delivery design and capabilities?
Dr. Varcoe: I would like to see longer self-expanding stents to manage long-segment disease. Deliverability doesn't seem to be an issue, and the rapid exchange system is fine if the lesion is adequately prepared. We've had some really encouraging results with bioresorbable scaffolds used BTK, and I think they are particularly well suited to this vascular territory.15 However, I would like to see future drug-eluting bioresorbable vascular scaffolds with thinner struts, more rapid resorption profiles, and longer lengths and be more easily visualized on fluoroscopy.
Dr. Mustapha: In terms of stents, I stand by my previous statement of the need for a stent that is self-expanding with strong radial force, long-term drug emission, the ability to conform to the tapering aspect of the tibial arteries, and fracture resistance. This type of stent could treat the entire spectrum of tibial disease from proximal to distal.
Imagining a setting in which DCBs, DESs, and adventitial delivery devices are all available, what is your prediction for how they might be algorithmically selected, weighing durability, cost, and future revascularization needs?
Dr. Varcoe: This is a difficult question considering that there is so much we've yet to understand about adventitial delivery devices—not only whether they are effective, but also if they are safe, the technique to best facilitate treatment of the entire treated segment without geographic miss, the best pharmaceutical agent to use, and toxicity concerns.
If in the future we have results that show that DCBs and adventitial delivery systems work effectively to preserve an open artery after intervention, then you might consider them interchangeable as methods to treat long-segment disease without the need for a metallic implant. My algorithm would be to use a DCB/adventitial delivery system for long-segment disease and areas poorly suited to stents (bifurcations, small arteries, those within 10 cm of the ankle/foot). I would reserve DESs for shorter, proximal calf artery lesions and as bailout for recoil/dissection after DCB/adventitial delivery system use.
Prof. Brodmann: My algorithm would be adequate vessel preparation in all patients, with much more atherectomy than we do now, followed by a DCB and only spot stenting if mechanically needed. Spot stenting could be done with bare-metal stent designs.
Dr. Mustapha: When you mention eventual drug delivery, I can see the variation in the consistency of delivering the proper drug to the proper location precisely each time. At present, we don't have that and therefore this would be my last choice. Balloon-expandable DESs fit well and also have data to support their benefit in the proximal tibial arteries. DCBs are my primary choice at this point, with proper balloon-to-vessel sizing after the adequate vessel preparation has been done.
Dr. Micari: I think that even determining an algorithm is difficult—DCBs, DESs, and adventitial devices should be used in a complementary manner. First, I would use the no-stent techniques, but I would consider stenting in the same artery where needed as bailout or provisional use. Primary stenting should be preferred in proximal, calcified, and relatively short lesions.
Do you expect paclitaxel to continue to be the primary drug used, or does this setting open the door for others such as the limus family?
Dr. Mustapha: Personally, I don't believe paclitaxel is the problem and is not the cause of the failed BTK tibial trials. Limus DCBs will fail as well if not properly used. We are missing a major point in the concept of DCB BTK therapy, which is the extensive obstacles coming from the tibial arterial wall and lumen for any drug we choose to use. We must focus on methods of building paths into the vessel wails, so when the drug arrives to the target area, it will transmit itself as designed with its excipient to the control center of proliferation so it can be immediately effective in preventing proliferation. Until then, we continue to do our best with aggressive vessel preparation and proper sizing of balloon-to-vessel ratio of at least 1:1.1.
Dr. Micari: I expect to see different drugs, as well as limus drugs, coming out. If satisfactory results are achieved from the current DCB trials, more investments will be allocated in the field and more molecules will be studied and targeted in the tibials.
Prof. Brodmann: My assumption is that drugs other than paclitaxel for BTK disease will be recognized and used in the future.
Dr. Varcoe: No, DES data suggest that paclitaxel is less effective than rapamycin analogues BTK.16,17 The jury is still out on DCB drug coatings, but now that rapamycin drugs are being evaluated in trials of DCBs above the knee, it opens the door to a BTK-specific rapamycin analogue–coated balloon.
1. Zeller T, Beschorner U, Pilger E, et al. Paclitaxel-coated balloon in infrapopliteal arteries: 12-month results from the BIOLUX P-II randomized trial (BIOTRONIK'S first in man study of the Passeo-18 LUX drug releasing PTA balloon catheter vs. the uncoated Passeo-18 PTA balloon catheter in subjects requiring revascularization of infrapopliteal arteries). JACC Cardiovasc Interv. 2015;8:1614-1622.
2. Zeller T, Baumgartner I, Scheinert D, et al. Drug-eluting balloon versus standard balloon angioplasty for infrapopliteal arterial revascularization in critical limb ischemia: 12-month results from the IN.PACT DEEP randomized trial. J Am Coll Cardiol. 2014;64:1568-1576.
3. Mustapha JA, Finton SM, Diaz-Sandoval LJ, et al. Percutaneous transluminal angioplasty in patients with infrapopliteal arterial disease: systematic review and meta-analysis. Circ Cardiovasc Interv. 2016;9:e003468.
4. Razavi MK, Mustapha JA, Miller LE. Contemporary systematic review and meta-analysis of early outcomes with percutaneous treatment for infrapopliteal atherosclerotic disease. J Vasc Interv Radiol. 2014;25:1489-1496.
5. Romiti M, Albers M, Brochado-Neto FC, et al. Meta-analysis of infrapopliteal angioplasty for chronic critical limb ischemia. J Vasc Surg. 2008;47:975-981.
6. Bosiers M, Peeters P, D'Archambeau O, et al. AMS INSIGHT—absorbable metal stent implantation for treatment of below-the-knee critical limb ischemia: 6-month analysis [published erratum appears in Cardiovasc Intervent Radiol. 2009;32:422-423]. Cardiovasc Intervent Radiol. 2009;32:424-435.
7. Fusaro M, Cassese S, Ndrepepa G, et al. Drug-eluting stents for revascularization of infrapopliteal arteries: updated meta-analysis of randomized trials. JACC Cardiovasc Interv. 2013;6:1284-1293.
8. Katsanos K, Spiliopoulos S, Diamantopoulos A, et al. Systematic review of infrapopliteal drug-eluting stents: a meta-analysis of randomized controlled trials. Cardiovasc Intervent Radiol. 2013;36:645-658.
9. Antoniou GA, Chalmers N, Kanesalingham K, et al. Meta-analysis of outcomes of endovascular treatment of infrapopliteal occlusive disease with drug-eluting stents. J Endovasc Ther. 2013;20:131-144.
10. Ward C, Mena-Hurtado C. Novel use of pillows and grooves: the Chocolate PTA balloon catheter. Endovasc Today. 2014;13:24-28.
11. Rastan A, McKinsey JF, Garcia LA, et al. One-year outcomes following directional atherectomy of infrapopliteal artery lesions: subgroup results of the prospective, multicenter DEFINITIVE LE trial. J Endovasc Ther. 2015;22:839-846.
12. Shammas NW, Lam R, Mustapha J, et al. Comparison of orbital atherectomy plus balloon angioplasty vs. balloon angioplasty alone in patients with critical limb ischemia: results of the CALCIUM 360 randomized pilot trial. J Endovasc Ther. 2012;19:480-488.
13. Werner M, Scheinert S, Bausback Y, et al. Bifurcation stenting after failed angioplasty of infrapopliteal arteries in critical limb ischemia: techniques and short-term follow-up. Catheter Cardiovasc Interv. 2013;82:E522-E528.
14. Katsanos K, Diamantopoulos A, Spiliopoulos S, et al. Below-the-ankle angioplasty and stenting for limb salvage: anatomical considerations and long-term outcomes. Cardiovasc Intervent Radiol. 2013;36:926-935.
15. Varcoe RL, Schouten O, Thomas SD, Lennox AF. Experience with the Absorb everolimus-eluting bioresorbable vascular scaffold in arteries below the knee. JACC Cardiovasc Interv. 2016;9:1721-1728.
16. Spreen MI, Martens JM, Knippenberg B, et al. Long-term follow-up of the PADI trial: percutaneous transluminal angioplasty versus drug-eluting stents for infrapopliteal lesions in critical limb ischemia. J Am Heart Assoc. 2017;6:e004877.
17. Bosiers M, Callaert J, Keirse K, et al. One-year outcomes of the paclitaxel-eluting, self-expanding Stentys stent system in the treatment of infrapopliteal lesions in patients with critical limb ischemia. J Endovasc Ther. 2017;24:311-316.


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subset: commoncrawl


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In business, treat competitors with caution (opinion)
Special to the NNBV
Today, I'd like to share real-life stories about recent deals and where the buyers came from.
Let's start with competitors.
Because of the risks involved, these types of buyers need to be approached cautiously.
A client of mine was a highly successful subcontractor in Reno who wanted significant market share in Carson City but was unable to obtain it. The reason was simple-my other client in Carson City.
The solution was obvious-Bring the two together. The result was both the seller in Carson City and the buyer in Reno got what the wanted.
To further illustrate this point, the seller signed a six-month employment contract with the buyer, but is still happy there two years later.
Another type of buyer is the strategic acquirer. A recent client of mine was a construction contractor who wanted greater control of materials and transportation of products he used.
To accomplish this, he bought a successful company already serving this market. The synergy that was created for the buyer helped foster the results they were looking for.
Career-change buyers represent the largest group of buyers. Some are big. Some are small.
I've had clients who excelled in the hospitality industry but bought a local restaurant because they wanted to be there own boss. At the other end of the spectrum, I've had a lawyer who tired of the profession and bought a large construction company because he wanted a new challenge.
Although they might not have a specific knowledge of the business they're buying, these types of buyers bring a different skill set to the business, which complements what is already there.
If career changers are the largest group, employees who purchase companies are probably the smallest. Many owners would like to sell to an employee, but a problem that often arises is that the employee doesn't have enough money to consummate the deal.
However, a deal we recently brokered between the owner of a local retail business and an employee who could afford the transaction proved it can work.
Regardless of what type of buyer is involved, there are common steps that need to be taken to ensure there are no surprises. That is just not good business.
Buzz Harris is a licensed business broker with The Liberty Group of Nevada. Reach him at email@example.com or 775-825-3948.
Vegas Chamber presses delegation for business liability protection
Concerned that a spate of COVID-19-related lawsuits could bankrupt businesses, members of the Las Vegas Metro Chamber of Commerce implored the state's congressional delegation during the chamber's annual D.C. retreat to pass a federal liability protection measure.


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Brewers right-handed reliever Rob Wooten has been outrighted to Triple-A Colorado Springs, according to the club's transactions page.
Wooten, 29, appeared in four games for the Brewers this season, yielding eight runs on five hits and six walks. Never a flamethrower in previous seasons, Wooten's fastball velocity dipped to 87.9 mph in his small sample of work in 2015. This season's unsightly results aside, Wooten has some encouraging career peripherals, including a 48.1 percent ground-ball rate, a 3.21 FIP and a 3.61 SIERA.
Wooten becomes the second reliever removed from Milwaukee's 40-man roster in recent weeks, as the team also outrighted former closer Jim Henderson's contract to Colorado Springs. Wooten's outright brings the Brewers' 40-man roster to 38.


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Is that a subset like the Hasidic or Orthodox branches? Could it be a death metal band? And exactly how can Louis Farrakhan tell the difference? I've had the pleasure of meeting many Jewish men and women over the years and not a single one of 'em has introduced themselves to me as being the "Satanic" variety.
Perhaps I didn't ask the right questions.
Please also note that I did not, and will not, refer to Mr. Farrakhan as "Minister" or "Reverend" because he has neither earned, nor does he deserve either title. If he was referred to as "The Race Baiting and Hate Spewing Bleep Louis Farrakhan, I'd be down with that.
By now, I'm sure you've figured out two things.
First, I'm sure you've heard that Facebook and Instagram just banned Alex Jones and Infowars, Paul Nehlen, Milo Yiannopoulos, Paul Joseph Watson, Laura Loomer, and Louis Farrakhan under their "dangerous individuals and organizations" policy.
"We've always banned individuals or organizations that promote or engage in violence and hate, regardless of ideology," a Facebook spokesperson declared, "The process for evaluating potential violators is extensive and it is what led us to our decision to remove these accounts today."
Yeah! And some of you regular folks are so much worse on social media and they don't do anything about it!
Second, the self-appointed Pope of Chicago's inner-city St. Sabina Church, Father Michael Pfleger, invited Farrakhan to speak to his congregation after the ban because what would a Thursday night Catholic get together be without a little hate speech thrown in for good measure.
And sure enough! It was at that very gathering that Farrakhan, after proudly proclaiming his abiding love for Jews everywhere, said, "I just know the truth. And I'm here to separate the good Jews from the Satanic Jews."
It sounds like he's doing the laundry. And please tell me who appointed him as judge and jury of Jews anywhere? So much for "Judge not, lest ye be judged?" I know the truth, too, and I certainly know a big mouth racist bigot when I see one, because this bilge is just the latest in a long string of anti-Semitic comments.
Here are some of this abject reprobate's despicable greatest hits:
It is now becoming apparent that there were many Israelis and Zionist Jews in key roles in the 9/11 attacks. Israelis had foreknowledge of the attacks… We know that many Jews received a text message not to come to work on September 11
Apparently those 400 Jews who died in the Twin Towers didn't get the text.
The false Jew will lead you to filth and indecency. That's who runs show business. That's who runs the record industry. That's who runs television.
"False" Jews? What happened to the "Satanic" ones?
The white people running Mexico are Mexican-Jews.
I don't think I've ever met a white Mexican Jew! The concept sounds a lot like a unicorn.
The false Jew will lead you to filth and indecency. That's who runs show business. That's who runs the record industry. That's who runs television.
You mean Barry Gordy was Jewish? First Sammy Davis Jr. and now this?
And then there's my personal favorite:
Pedophilia and sexual perversion institutionalized in Hollywood and the entertainment industries can be traced to Talmudic principles and Jewish influence.
The man certainly possesses a rather vivid imagination, doesn't he?
C'mon! This is the same tired old "common enemy" scapegoat BS that Adolph Hitler used to come to power in 1933 Germany. The only things missing here are the colorful armband and funny little mustache.
Perhaps Mel Brooks could write a musical about him.
I expect nothing less from Farrakhan because I couldn't possibly expect any less of him. He's always been an anti-Semitic gay bashing self-appointed "prophet" who will do or say anything to stay in the spotlight.
But as bad a Father Pfleger can be, especially when it comes to any form of publicity and self-aggrandizement, I never thought he'd stoop to the level of inviting a world-class hatemonger to infect his parish. And they lapped it up, too!
And when Chicago Cardinal Blaise Cupich admonished Pfleger thusly:
Minister Farrakhan could have taken the opportunity to deliver a unifying message of God's love for all his children. Instead, he repeated smeared the Jewish people, using a combination of thinly veiled discriminatory rhetoric and outright slander.
Pfleger responded by saying, "I think that Jesus said in the scriptures, that leave judgement to the Father."
That's funny! Because when it comes to malt liquor manufacturers, cigarette companies, the Illinois Lottery, drug paraphernalia stores, rappers, Howard Stern, and gun shops Pfleger has no problem standing in for God. In fact, he frequently thinks he is God.
But what really frosts my cookies is my liberal compatriots love to believe that Donald Trump has cornered the market on intolerance. While the President is certainly no role model, if it comes down to expecting more from a con man or two high-profile "spiritual leaders," you know where that bleep is gonna to land.
I cannot believe that, in 2019, we're still dealing with this level of institutionalized anti-Semitism. It simply refuses to die. And for it to come on behalf of any priest is simply beyond the pale. Does the Catholic Church really need any more bad publicity?
Cardinal Cupich! Remove Father Pfleger from St. Sabina's now if you have to personally drag him out. It's something that should've been done years ago.
Talk about false prophets. Bruce Cockburn was right! You really do have to "kick at the darkness till it bleeds daylight."
Addendum 1
One of my favorite readers noted that NBC 5 Investigates will be covering the disastrous Illinois Youth Center in St. Charles on their Tuesday evening broadcast (5/14). It's about time that fiasco moved beyond The First Ward.
Addendum 2
To the anonymous individual who mailed me two of my Beacon-News columns, one from 2008 and the other from 2010, you made my day. Those former Sun-Times newspapers were always a difficult proposition, but I do have some very fond memories of specific editors and reporters that those clippings brought right back.
Thank you for saving them and taking the time to send them to me!


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It's amazing what one can do when there is no work to be done over the weekend and no out-of-town guests to host. J and I were beside ourselves on Saturday when we awoke and discovered we could do whatever we wanted. I didn't touch my computer–the thing that has been attached to me for at least eight hours a day for months on end. We just enjoyed ourselves doing little things I've had on my to-do lists for ages.
One of the things I have wanted to do since I read Birthing from Within is to spend some time creating birth art. She has some wonderful prompts that are great for working through pregnancy and birth. I'm a terrible painter, but I still love doing it, and we finally had time. Here are a few samples, and some appear to be blurry. Oh well.
The first is from a prompt asking me to depict what it will like for me to be in birth. In the end, I came up with a wave. I'm resting on the wave; I'm riding the wave, and eventually, I'm birthing within the wave. Here's what that looks like:
The next is something of a self-portrait:
And, while this looks like a hurricane, it's a practice in me visualizing my cervix opening, or rather, an abstraction thereof:
My wife created this piece, which I love. It's our birth with her, my mom, a midwife, and me (the naked one)
And J insists that I share this photo she caught of me painting. I'm wearing what I call my tomato shirt. When I wear it, I appear as though I'm 18 months pregnant (or a giant tomato), but it covers my belly, and that's more than can be said for most of my shirts these days:
Saturday morning, we went to one of our favorite local farms to get some tomatoes, eggs, and such, and we walked around their flower gardens–so beautiful. Here I am with the fields of sunflowers, zinnia, and more:
And some of the flowers:
We even found a yardsale–a multi-family yardsale–which turned out to be a family yardsale–three different families of lesbians. What fun! I'm telling you, it was a great weekend for this sort of thing.
By the time we got home, it was time for me to make my Chicken Tortilla Soup, so I spent some time up and cooking, and I also had some of my first productive-seeming contractions. I had to sit and breathe through them, and I felt some good pressure. This prompted us to pack our bags for the hospital. It feels good to have that done, even though Egghead isn 't showing any new signs of making his grand entrance soon. Later in the evening, a friend came over to take photos of me, and I'll share those once I've processed them (within a day or two). It was such a lovely time, and it's great to have some photos so close to Egghead's arrival. It was a lovely day all around.
Today, we have a midwife appointment, and I get to have my hair cut. More updates to come, but I just had to share because it feels so damn good to have something positive to write about, to feel this lightness about me. I am so grateful for all of these moments.


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Is there any recommended food places after 8pm or even 9pm? Staying close to Akihabara and willing to travel for a bit!
Last updated
Answers 1
How about exploring Kanda area? It's walkable distance from Akihabara and there are many many Izakaya (Japanese pubs) and bars. The area is developed from long time ago so some of them are really historical. You will find tremendous amount of dining places around Kanda Station.
I'll go check them out !! Thanks ! ^^
There are great soba restaurants in the area but it closes at 8pm :( The place is called Muromachi Sunaba, if you have a chance to visit, it is highly recommended! The place continues more than 100 years.


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How Does Hair Detox Shampoos Function?
It is crucial for us to understand that you can consider taking numerous drug tests that are available on the market. However, most of them happen to pass them in case that you have consumed something recently.
The main confusion and problem happen with hair follicle drug test, primarily due to the idea that it is highly challenging to pass and cheat it. This particular drug test functions based on a specific situation, but the technician will take part in your hair from the shaft.
It is a common choice in the criminal justice system as well as the pre-employment procedure that will help you along the way.
Since it is impossible to fake it because the technician will take samples of your hair directly in the lab, you should think through other methods of tampering with this screening.
One of the best ways to pass it is by using the Aloe Rid detox shampoo old formula in combination with other chemicals that will reduce the amount of THC until you reach the point of passing drug screening.
A hair drug test is one of the best ways to check the long-term drug abuse, which is vital for both employers and law enforcement. It requires a few days of testing before you can get proper results, which means that you will be able to be positive on THC, for instance.
Hair Drug Test 101
This particular drug screening method can easily detect previous drug use for up to three months based on various drug types. As soon as you decide to consume something, it will enter your bloodstream, which means that your follicles will be filled with that compound.
You will need a few days for the hair to grow from the follicle that features banned substance, which means that you will not be able to pass a test. That is why most technicians are cutting new hair because that is the best way to determine the frequency of drug abuse.
It can detect a wide array of drugs such as marijuana, barbiturates, cocaine, heroin, PCP and prescription medications and opioids. For instance, when you consume weed, THC will enter your bloodstream.
In a matter of hours, our natural metabolic and detox system will break THC into its metabolites such as THC-COOH, and that is the substance that labs will check for. The best way to learn more about hair follicle drug test is by clicking here for more information.
What Happens During The Test?
As soon as an employer decide to summon you for a drug test, you will have to go to a specific place in which administrators will professionally remove 1.5-inches sample of your hair directly from the shaft and closest to scull.
They will cut 1.5-inches, due to the idea that human hair tends to grow for 0.5-inches monthly, which means that the test will determine the drug abuse in the last three months. Finally, they will give you results in a matter of a few days, and you can see whether you are positive or negative.
How to Beat It?
- Abstinence – The simplest and most problematic way for passing a hair drug test is through abstinence that has to happen at least 100 days before the date. The main problem with it is that you will not get a particular period that will allow you to reduce the number of drug metabolites. This is the best choice for individuals, especially if you have a plan to start working your dream job in the next few months.
- Shave Completely – You have to be cautious when it comes to shaving your entire body because that will show others that you are guilty and that you are hiding something. At the same time, it is not enough to shave your head, because administrators will take samples from your body, and you will not pass the test.
- Hair Detox – You will be able to beat this particular test by conducting detoxification, but not from the inside, but the outside. You should visit this link: https://www.wikihow.com/Pass-a-Drug-Test to learn more on how to pass different types of drug tests. Since hair represents dead cells, you will not be able to cleanse yourself by performing regular detox through diet and supplementation. Instead, you should find appropriate detox shampoo in combination with other chemicals and remedies that will help you cleanse yourself thoroughly.


text: The college supports students who wish to have an international experience by working with them on an individual basis; and individual Wilson professors/staff offer Study Abroad opportunities. For more information on study abroad opportunities, contact our Study Abroad Coordinator, Crystal Lantz. New students are expected to attend the Study Abroad/Internship session that is offered during fall orientation. This program will provide you with great information about our global initiatives and internship processes.


text:
Andrew Jackson's lack of positive actions and policies ultimately
forced the westward migration of the "five civilized" Native American
tribes, the Creeks, Chickasaws, Seminoles, Cherokees and Choctaws.
Jackson's failure to enforce his early promise that the migration of the
Native American tribes would be voluntary was a major factor in the success
of the forced migration, as were Jackson's repeated failures to ensure that
treaties with Native Americans were kept and that land deals with Native
Americans were not fraudulent.In addition, other legislation like the
Indian Trade and Intercourse Act of 1834 resulted in more migration out of
the area, by reducing native rights and sovereignty.Further, Jackson's
role in forwarding the forced migrations was likely motivated by a desire
for profit and land, political concerns, and racism.
In The Long, Bitter Trail: Andrew Jackson and the Indians, Anthony
Wallace describes the forced removal of thousands of Native Americans from
the American east to an area west of the Mississippi River through the
Indian Removal Act of 1830.The author focuses on how the policies of
Andrew Jackson impacted the relocation, who as a newly elected president
faced a caucus that was deeply divided over the relocation of the Native
Americans.Ultimately, Jackson became on of the most vocal and active of
the proponents of the forced removal of the Native Americans.
A professor of history and anthropology at the University of
Pennsylvania, Wallace is clearly qualified to write this history.He has
written a number of books, including the Bancroft prize-winning Rockdale
The Indian Removal Act of 1830 resulted in the forced removal of the
five "civilized tribes" that lived in the geographical area east of the
Mississippi River.The move displaced large numbers of the Cherokee and
Choctaw tribes, but also affected a number of other tribe…
Andrew deals with Native Americans were not
Andrew Jackson's lack of positive actions and policies ultimately


text:
Elminster wrote:He will definitely outrun me eventually. He gets his counts on the Fiction section.
Not often enough, hehehehe
Official home of the Starfire Design Studio and the Starfire Community
Moderators: SDS Members, SDS Owner
Elminster wrote:He will definitely outrun me eventually. He gets his counts on the Fiction section.
AlexeiTimoshenko wrote:Not sure if you saw it but we hit 30 registered users in a 24 hour period this morning.
Vandervecken wrote:Most users ever online was 91 on Wed 07 Aug 2013 11:51
Woot !
Vandervecken wrote:I'm seing it still when you look at bottom of the main page of the Forum; in fact, I copied and pasted from that page. I added the underline under 91 though. And NO they weren't REGISTERED USERS, but according to your own page we had 91 users on that date and it WAS a new record according to the internal forum data tracker. There is a different tally for REGISTERED USERS. It says - (#) Users active over the last 24 hours:(Name list)
Cralis, I may have to 'see some proof' that you are not reading these boards while sleep-walking. Heheheee.
Users browsing this forum: No registered users and 5 guests


text:
Watch Slugterra
Add to Watchlist
Slugterra is a computer generated animation focusing on the underground world of Slugterra that is occupied by a variety of humans and mythical creatures. The show was produced by Nerd Corps. Entertaiment for the Disney XD channel in North America and has spawned two seasons for a total of 26 episodes each lasting around 22 minutes. Slugterra is the brainchild of Asaph Fipke, an expert in computer generated animation who has produced shows for networks, including Cartoon Network and YTV; Slugterra uses an animation style similar to those used in many Japanese Anime series.
The main focus of the animated series Slugterra is the character of Eli Shane who has spent the majority of his life on the surface of the planet Earth being tutored by his father, Will Shane. Throughout his life Will Shane has been responsible for protecting the underground world of Slugterra from invasion by evil forces, including the main bad guy of the series Thaddius Black; following a battle with Black, Will Shane has dissapeared. Following his father's dissapearance Eli Shane travels to the underground world of Slugterra on his own to search for his father and train to become the world's greatest slug slinger.
Once underground Eli Shane assembles a group of unlikely friends and helpers, including Pronto the Magnificent who is a tracker incapable of finding his way and telling directions. Pronto is commonly the butt of jokes by a cave troll, known as Kord Zane who helps protect the group. Another major character in the series is Trixie, a slug expert who can tell the difference between different species and heps the group escape when they face trouble they cannot overcome.
Throughout the show Eli Shane attempts to protect the underground world of Slugterra by using his slug slinging skills in duels against evil interlopers, mostly sent by Thaddius Black. Eli also attempts to relocate Will Shane and prove his slug slinging skills to his missing father and join him in being the main protectors of Slugterra.
Slugterra is a series that is currently running and has 3 seasons (53 episodes). The series first aired on August 20, 2014.
Slugterra is available for streaming on the website, both individual episodes and full seasons. You can also watch Slugterra on demand atHoopla, iTunes online.
- Disney
- 3 Seasons, 53 Episodes
- August 20, 2014
- Animation & Cartoon, Kids & Family
- Cast: Lee Tockar, Sam Vincent, Andrew Francis, Shannon Chan-Kent
Watch Full Episodes of Slugterra
Slugterra Full Episode Guide
- Episode 13 - Light As Day
Dr. Blakk has succeeded in creating a gap in the magical slug-energy barrier that protects Slugterra.
- Episode 12 - Dark As Night
Dr. Blakk and his Darkbane minions have discovered a way to make their ghouls faster and stronger.
- Episode 11 - Bandoleer of Brothers
Eli's got a new slug recruit, but in the heat of battle, can this rookie go from frightened novice to the hero of the day?
- Episode 10 - Back to Blakk
While the rest of the Shane Gang defend the perimeter from the Blakk Guards sent to free Dr. Blakk from prison, Eli interrogates the captured villain.
- Episode 9 - Upgrade
Dr. Blakk has been captured. Now, it's up to the Shane Gang to transport him to Stalagmite 17, the only prison that can hold him.
- Episode 8 - It Comes By Night
A mysterious creature is draining the energy from all the slugs in a distant cavern. The residents are offering a rich reward to whomever can stop it.
- Episode 7 - Lightwell
Burpy is sick, and the only thing that will cure him is a trip to the Lightwell, a mysterious hidden power source only slugs know the way to.
- Episode 6 - The Thrill of the Game
Our heroes are lured into an elaborate game by a twisted villain calling himself the Game Master.
- Episode 5 - Keys to the Kingdom
The Shane Gang follows Diablos Nacho to Molemound, the Molenoid home cavern.
- Episode 4 - Mission Improbable
The Shane Gang's been captured by the zombifying Mr. Saturday.
- Episode 3 - King of Sling
Locke and Lode have run roughshod over a cavern and the Shane Gang aims to kick them out.
- Episode 2 - Slugball
The Shane Gang find themselves competing in the Slugball Championship.
- Episode 1 - The Return
Armed with his powerful new weapon, the Gatling Blaster, Blakk's unstoppable battle train threatens to run roughshod over all of Slugterra.
- Episode 13 - What Lies Beneath
When Eli and the Shane Gang find themselves trapped in the Deep Caverns underneath Slugterra they discover a whole new type of danger threatening to escape.
- Episode 10 - The Gentlemen and the Thief
Using some stolen Shadow Clan tech, Dana Por is able slip in and out of any cavern in Slugterra - and rob them blind!
- Episode 9 - Deep Water Dark Water
Blakk has hired Brutale - a thug as brutal as his name - to build a Deep Water Rig to drill for Dark Water at the bottom of the Cavern Sea.
- Episode 7 - Roboslugs
Driven by his intense slug phobia, scientist Quentin Kozinski has invented mechanical slugs.
- Episode 1 - The New Kid, Part 1
After being chased by one of Dr. black's men the Shane gang are saved by a new kid named twist.


text:
- Currently, all proposals over $500,000, as well as a number of NIH programs and program policies, require a data sharing plan in the grant application. The NIH public access plan states that additional policies, including data management plan (DMP) requirements, were scheduled to be issued by the end of 2015.
- Scope: Digital Scientific Data, i.e. "the digital recorded factual material commonly accepted in the scientific community as necessary to validate research findings"
- Time frame for sharing: No later than the acceptance for publication of the main findings from the final dataset, however the NIH recognizes that the specific time will be influenced by the nature of the data collected.
- Designated repository: None specified by the NIH data sharing policy, however a number of programs and center data sharing policies do specify repositories.
- The NIH Data sharing policy went into effect in 2003; additional policies are expected by the end of 2015 or soon thereafter.
Additional information
- NIH Data Sharing Policy (in effect since 2003)
- NIH Data Sharing Policy and Implementation Guidance
- FAQ (NIH Data Sharing)
Key Elements to Consider in Preparing a Data Sharing Plan Under NIH Extramural Support
NIH Data Sharing Policies - list of Institutes, Centers, and Programs with specific data sharing and data management plan requirements (i.e. NIH Genomic Data Sharing Policy).
Individual requests for applications (RFAs) and program announcements (PA) may specify other requirements or expectations for data sharing that apply to specific projects.


text:
Black Chunky Chicks 2 (4 Disc Set)
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£3.003.00 12.00
(££12.00 per metre)
- Buy 6 or more for £2.85 each and save 5%
- Buy 12 or more for £2.70 each and save 10%
- Buy 40 or more for £2.55 each and save 15%
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Moda Fabric Prairie Cactus by Kansas Troubles Quilters Sold in multiples of 1/4 metres. The design is cactus rose the colour is green this fabric is excellent quality 100% cotton which can be used for patchwork and quilting, home decor, light to medium weight curtains, cushions, craft projects and for making beautiful clothes. The price is for a 1/4 metre (Approx 10 inches) of fabric and the width is approximately 44 Inches (1.10 metres). Multiple purchases will be cut in one continuous length (e.g. a quantity of 5 meaning 5 x 1/4 m = 1.25 metres, which would be cut and sent as a 1.25 metre piece)
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|Manufacturer Code
|9511 15
|Made By
|Main Colour
|Kansas Troubles Quilters
|Range Name
|Prairie Cactus
|Theme of Fabric
|Christmas, Country, Classic Prints
|Type of Fabric
|100% Cotton
|Available in the Future?
|Width of Fabric
|44 Inches Wide (112cm)
|Sold as
|Cut as a 1/4m Length x the width of the fabric. When you buy 5, we will supply 1.25m of fabric in one piece


text:
Ryan Reynolds' Mint Mobile Pokes Fun at 'Big Wireless' for Sports Stadiums
The budget carrier is giving away free service (again)
Mint Mobile might not have a big sports stadium in its name, but according to the budget mobile carrier's new spot, that's a good thing for customers.
The ad, voiced by Mint's eccentric owner and actor Ryan Reynolds, notes that the price tag on those stadiums—of which all the major carriers have at least one—must trickle down to consumers. And why would any mobile subscriber want to be paying for a sign on a stadium?
"We wanted to address the gorilla in the room," said Reynolds. "How can this thing be any good for $15?" Part of that answer, per the new spot, is that Mint doesn't pay for things like "money suck" stadium sponsorships, retail stores or celebrity endorsements.
Several sports are coming back this month, but without any fans inside the stadiums and arenas (a cautionary measure to prevent the spread of Covid-19), the cost of sponsoring them is looking even more absurd. To point that out and also prove that it stands with subscribers, Mint is sponsoring 15 "home stadiums" instead.
To score one of those sponsorships, entrants have to email a photo of their space to Mint with an explanation of why they'd be a good partner for the carrier (extra points for creativity). The 15 chosen winners will each receive a year-long 3GB wireless service plan and all the ingredients for a bona fide at-home stadium: a big Mint Mobile sign, jersey, pint glass, slippers, rally towel, oven mitt, bottle koozie and hat.
The callouts have become something of a theme in Mint's advertising since Reynolds purchased a majority share in the company last November. For the Super Bowl, Mint released a pointed statement on the cost of Big Game advertising. Instead of an ad, Mint opted to give away three months of free service to anyone who signed up during the Super Bowl.
In March, Reynolds left voicemails for all Mint subscribers to announce that the company was giving everyone unlimited data as a way to support them during the pandemic. In May, Mint dropped an ad in the form of an incoherent, yet hilarious PowerPoint presentation.
Despite a pretty consistent stream of his trademark brand messaging, Reynolds said he's not trying to rush Mint's growth. After he bought Aviation Gin in 2018, it "evolved into a 'hot' brand over a one- to two-year period," he said. "We'd like to see the same strong momentum with Mint in a similar timeframe. There's so much more frustration in the wireless industry. It will be fun."
As far as a collaboration between the two brands, Reynolds didn't rule out the possibility. "Both companies already have a 'Don't Aviation and Mint' policy to guard against drunk texting/calling, and there is certainly a world where we bring that message to a larger audience," he said.
The new spot was created by Reynolds' production company Maximum Effort.


text: "Off with her head" the queen shouted at Alice in the Lewis Carroll story "Alice's Adventures in Wonderland". Now I'm not sure if Lewis had an interest in gardening but he could well have been giving us some horticultural instruction which will give us a longer flowering season. There is a technique known as dead-heading, it is a simple task which takes a few minutes however adds days and sometimes weeks to your flowering display.


text:
Creag Mhor
Hear pronunciation Press to hear pronunciation
Creag Mhor is an unassuming hill in a remote Cairngorms location, topped by a granite tor. It rises to the northeast of the Fords of Avon and is usually climbed using the Lairig an Laoigh.
You have not climbed Creag Mhor.
Region: Cairngorms
Altitude: 895 metres
Detailed route description and map
Creag Mhor and Loch Avon from Glenmore
Other routes and challenges
The terrain means that approaches from any direction are possible, but the remoteness deters most - all other routes are epic. These include approaches up Glen Derry and over the Lairig from the Linn of Dee, or a trek up Glen Avon from Tomintoul.
Walker-friendly accommodation in the area
Kingussie / Newtonmore cottages


text:
Relationships are built upon a foundation of trust—between you and the people you serve—between you and the technology you use to support your mission. We operate under the imperative to ethically use technology and data to promote the individual and societal benefits of personal growth.
At Gloo, we believe that helping people be all that they were born to be transforms communities. With this as our foundation, we built a technology and data platform to scale the impact of Champions—the individuals, and organizations that help people grow.
Architected for the unique needs and considerations of Champions, Gloo's platform is the first of its kind built to improve lives, the health of families, and the vitality of communities.
As a technology provider, our first order of business was and continues to be leading the charge in implementing a trust architecture (including privacy, security, and regulatory compliance) that organizations and individuals alike should insist upon.
See below for access to our specific policies available online.
At Gloo, we're proud to work with some of the best people and organizations in the world. The Champions we serve do important work every day, such as:
Provide incarcerated fathers with character and job skills so they can thrive when they return to their families
Counsel couples to help them improve their relationships
Treat people who struggle with alcohol and opioid abuse
Teach families important financial skills so they can live generously
Guide individuals who are looking to explore their spirituality
Drive city-wide health and wellness transformation
We're committed to ensuring these service-minded organizations can benefit from the countless ways technology helps them leverage their impact.
New technology, data, and analytics are transforming the world as we know it. We empower our Champions with the informed tools to know more about whom they serve so that they can match us to content, people, and products.
We want to get the right technology into the hands of Champions so they can change more lives for the better.
Our architecture, policies and practices anchor in our commitment to stewardship and providing a trusted platform. An abbreviated set of highlights is set forth for you below.
Data rights are fundamental rights. Gloo takes a very conservative position as to what constitutes personal information by anchoring in the California Consumer Protection Act (CCPA). Therefore, for Gloo, "personal information" means any information that is reasonably capable of being associated with a particular consumer or household. By doing so we err on the side of the data subject.
Data Subject Rights. We're committed to honoring data subject rights. These include the right to request access, deletion and change your personal information as required by laws like GDPR (for EU data) or CCPA (for personal information from residents of California). We celebrate policy developments like CCPA and GDPR because they drive transparency and give you control over your information.
Trust by Default. Our offerings were designed through our integrated trust by design process, guided by privacy impact and security risk assessments and the principle of data minimization.
Privacy by Design. Unless we have obtained your express consent, we will not share your personal information. Otherwise, only aggregate data which, by definition, is not identifiable in any manner, is reported. These are statistical measures only.
For privacy, Gloo operates in accordance with HIPAA, GDPR and CCPA. We work with the nation's leading privacy experts from Baker McKenzie, Bryan Cave Leighton Paisner, and Greenberg Traurig.
For security, Gloo operates according to the NIST CSF framework, has completed multiple security audits and uses a registered AICPA firm.
Every day, we make a promise to our Champions, our employees, and the public:
We promise to provide a platform anchored in the rights of the individual, the responsibilities of the organizations that serve them, and the appropriate collective actions of the ecosystem as a whole.
Gloo will always choose to anchor in principles of transparency, choice, and the unwavering commitment to put people's well-being at the center of everything we do.
We'll continue the important work of being a trusted steward and helping our Champions be the same, so they can continue the good work of helping others be all they were born to be.
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The ballot for this year's primary elections in Lakewood, NJ, will have a cast of candidates who have never run for office before. On the Democratic ticket, challenging Mayor Raymond Coles and his running mate Moshe Raitzik, is David Gruman. A newcomer to politics, David has a successful online business, is a former talmid of Bais Medrash Govoha and a lifetime Lakewood resident.
David likes to see the good in people and he has nothing against anyone who is currently on the township committee. What does concern him is that there are issues in Lakewood, and he feels that the issues aren't being dealt with quickly enough.
"Part of the problem is that people in office are always supposed to be kept on their toes," says David. "The people on the committee have all been there for a long time and that is very unhealthy. People should be in office for a few years and then move on in order to allow others with enthusiasm to take the reins of the township. The system that we have in Lakewood allows officials to grow complacent. In the beginning, every new member of the committee feels the urgency to accomplish and effectuate change. After a few years in office-knowing that elections are easily won once a person has brand-name recognition-the urgency is gone and the committee member grows stagnant."
David is a big believer in term limits and that is one of the first issues that he would like to tackle when he wins a seat on the township committee. He feels that any problem that we might have in Lakewood, whether it is traffic, taxes or any other issue, is due to the fact that the members of the committee have been there for multiple terms. The lack of innovation in dealing with Lakewood's problems is a direct result of the low turnover rate on the committee according to David. New members would bring new ideas and vigor to the committee and would better reflect the opinion of the common resident.
Although the issue of invoking the Faulkner Act has been a topic of conversation for many years now, David believes that it is something that should be worked on in addition to creating term limits. Term limits would put pressure on elected officials to perform, but more importantly, having a directly elected mayor would force the mayor to take control and make sure that issues are dealt with expediently.
One area that speaks to David's expertise, is managing budgets. In regard to the township's budget David remarked: "It is sad to see that year after year the township hires the same engineer, law firm, etc., while their compensation continues to increase. In the business world, professionals don't take anything for granted-they assume that the only way that a company will retain them, is if they remain competitive and perform to the standards of the company. Performance reviews and price shopping are common business practices. The same holds true for vendors and any other expenditure. For the most part, businesses operate with zero based budgeting, where prior year spending is not a given for the coming year. There is no reason why government should be any different."
David is also concerned about the planning and zoning boards in Lakewood. He feels that members should be switched out more frequently. The dynamics of the boards have to change periodically in order to allow for new opinions to infiltrate the thinking of the boards. This would prevent board members from getting cozy with special interest groups. Amazon has a practice where employees are shuffled from department to department to avoid favoritism between sellers and employees. It is time to set up an oversight committee that will evaluate the performance of the board members to ensure that current and future board members have the best interests of all of the people of Lakewood in mind, and to avoid any conflicts of interest.
Over the years, there seems to have been a push by the township to increase housing in Lakewood. In David's opinion, although it is important to look to the future, it is also important to look back and take note that there has been too much effort put into increasing housing and not enough emphasis has been placed on improving the infrastructure. David feels that this has to be reversed in order for there to be a proper correction in town. Going forward, the boards and the committee MUST take a forceful stance against new housing. Variances should only be granted on very rare occasions. No more spot zoning should take place in Lakewood.
The severity of our traffic situation hasn't been realized yet. We see glimpses of what is to come whenever a main artery is temporarily shut down for maintenance or emergencies. The impact of such occurrences can be devastating to the vehicular traffic flow in town. If we continue the way we are going then these cases of gridlock will become the norm.
In light of this, David recommends that swift action be taken. "There is no need to perform traffic studies to figure out that we need a traffic light on Pine Street and MLK," says David. "When you see that an intersection is confusing, take care of the issue immediately. Enough with costly studies! If something is obvious, why harp on it? Fix the issue and move on!" There are so many areas that could use a turning lane or a new thoroughfare altogether in order to relieve the traffic in the area. Tired of always hearing talk of what could be done to fix traffic, David quips: "actions speak louder than studies."
David has lived his entire life in Lakewood Township. He loved the Lakewood of old, he loves Lakewood for what it is today and he is hopeful for a better Lakewood to come. David concludes: "I feel that the next three years will be very crucial to Lakewood's future. It is my hope that during these formative years, I will be able to play an important role in steering Lakewood in a positive direction. As a member of the township committee, I will be a voice for all of the people and will work hard to make this town a place to be proud of once again."
By M. Solomon – Matzav.com


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Department of Chemical Engineering, Faculty of Industrial Technology, Universitas Ahmad Dahlan (FTI UAD) was visited Prof. Dr. Helmut Erdmann (Flensburg University of Applied Sciences Germany). It was the second time Prof. Dr. Helmut Erdmann visited UAD. Prof. Dr. Helmut Erdmann was welcomed by Vice Rector IV of UAD, Prof..More »
Department of Electrical Engineering, Faculty of Industrial Technology, Universitas Ahmad Dahlan had conducted a general lecture on Wednesday 7th of December, 2016. The lecture was delivered by Prof. Dr. Jafri Bin Din From Universiti Teknologi Malaysia. Universiti Teknologi Malaysia (UTM) is one of international partners of Faculty of Industrial.More »


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Thon Hotel Astoria
Norway, Oslo
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Hailed as one of Oslo's most central hotels, this charming establishment is situated close to the city's main street, Karl Johan. The hotel is located just a few minutes' walking distance away from the Oslo Central Station, offering ease of access to other areas to be explored. Just a short distance away from the hotel lies a myriad of shopping districts, tourist attractions, restaurants and bars. Guests of this hotel will find themselves in the ideal setting from which to explore the wonders the city has to offer. This charming hotel welcomes guests with warm hospitality and excellent service. The guest rooms are beautifully decorated and feature soothing tones and hints of vibrant tones. The rooms offer a relaxing setting in which to completely unwind at the end of the day.
Wifi / Internet access
Room Service
Air Conditioning


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Agarwood resin production and resin quality of Gyrinops walla Gaertn
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MetadataShow full item record
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Copyright © 2013 S.M.C.U.P. Subasinghe and D.S. Hettiarachchi
Agarwood is a resin produced by certain species of family Thymalaeaceae due to a self-defence mechanism. Most species of Aquilaria and a few species of Gyrinops, Aetoxylon and Gonystylus are capable of producing agarwood. Gyrinops walla, a member of the family Thymalaeceae is recorded only in the wet zone of Sri Lanka and very rarely in southwest India, has not been previously studied to identify its ability of producing agarwood. Therefore the present study was the first ever to conduct and identify the production of agarwood in G. walla and the quality of its resins. Six G. walla trees growing in two distinctive areas of the wet zone of Sri Lanka were used for the present study. All six trees had natural wounds occurred sometime before the sample collection due to abrasions or fallen branches. The dark coloured tissues of the affected areas were carefully collected without cutting the trees and resins were extracted by solvent extraction method. The extracted resins were analysed using gas chromatography to identify the different compounds. Finally these compounds were compared with that of selected Aquilaria species. The results revealed a strong similarity of resin compounds of G. walla with that of Aquilaria species which are commercially used to collect agarwood. Further studies should be conducted to identify the effects of artificial resin induction methods on G. walla that are already used on Aquilaria species.
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Nissan Sport Sedan Concept Screams at Maxima Volume
Nissan has just dropped the curtain on a Sport Sedan Concept today that hints at a future production sports sedan.
In layman's terms, this is an indication of what the next Nissan Maxima is going to look like. It features Nissan's next-generation design language including the 'V-Motion' front, 'floating' roof and boomerang-shaped lamps. This concept is the third in a trio of concepts shown by Nissan that share these new design aspects, elements that will be adapted to all future Nissans.
The exterior of the Sport Sedan Concept has low, wide proportions, with a lower hoodline and reduced ground clearance compared to contemporary sedans. The Concept rides on custom 21-inch wheels with ultra-wide 275/30R21 tires.
Inside, diamond-shaped graphics are placed on the quilted seats, stitching and trim panels. Nissan claims the diamond treatment adds a three-dimensional feel to the interior compared to traditional flat surface designs.
The Sport Sedan Concept is powered by a "300-plus" horsepower 3.5-liter V6 engine connected to Nissan's ubiquitous Xtronic CVT sending power to the front wheels. If this doesn't scream future Maxima, we don't know what does.
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GALLERY: Nissan Sport Sedan Concept
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Master of the Mix Open DJ Auditions
Do you think you have the DJ skills to be on TV? Well if you do, then you need to check out the Master of the Mix Open DJ auditions for Season 2 where BET, Centric, and Smirnoff are hosting DJ battles in Houston, Miami, Atlanta, NYC, and Detroit to determine which DJ's will be selected for the show. They are actively searching for 8 of the Nation's Best DJ's who will journey across the US to face challenges that will test their DJ skills to find out who will be the next Master of the Mix. The winner will get $250k in cash and prizes along with other perks that come from being the Master of the Mix. Details, locations, and entry links are below. Good Luck to the participants and make sure you drop me a line if you are trying to become the next Master of the Mix so that we can also feature your videos on our Turntablism Video Friday series.


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"Hobbit" star Martin Freeman hosted 'Saturday Night Live" this weekend, and let's just say, questing in Middle Earth over the last few years hasn't stamped out his sense of humor.
In one of the show's best skits called "The Office: Middle Earth," Freeman reprises his Tim role from the BBC hit "The Office," but this time as Bilbo Baggins.
Other hysterical standouts include Bobby Moynahan as Gandalf, channeling Ricky Gervais, and Taram Killam as put-upon Gollum, who looks a little like Rainn Wilson's Dwight from the US version of "The Office."
You have to check out this hilarity!


text: Your body has a language all its own – but do you really know how to listen? Dr. Oz tips you off to the body noises you should be aware of and when they could be a sign of something serious. Click here to learn more about acid reflux and heartburn, and click here for more on gluten intolerance and celiac disease.


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What does 'Let your guard down' mean?
If you let your guard down, you relax and stop looking out for danger.
- Category: General
Buy our lists of British English, American English and Animal idioms in PDF format. They're perfect to use offline for reference or for use in class!
See also:
- View examples in Google: Let your guard down
- Discussion Forum: English Idioms and Sayings
- Idiom Definition
- Idiom Quizzes


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The Glorious Rebellion
Scholars Of WarYear Released: 2019
Format: Download
Label: Sludgelord
Reviewed by Alex Deller on Apr 17, 2019
An EP's worth of rowdy stuff wherein the worlds of noise-rock, sludge and hardcore collide. As you'd expect, feedback whistles, riffs club relentlessly away and vocals are delivered with much spite. The first two tracks are concise and keep their scope limited, while closer 'Burn It Down' claws its way dutifully past the nine-minute mark just because it wants the hurt to last. In their finer moments they recall some sort of mix-it-up between Deadguy, KEN mode and Unsane, though it has to be said that they never get close to the mania or desperation exhibited by those three greats. Instead, as they below repeatedly on the opening track of the same name, "this is fine."
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Jojoba is a liquid wax similar in structure to skin's own sebum. It nourishes and moisturises skin, smoothing the appearance of wrinkles and soothing damaged skin. Rich in antioxidants, Omega 6 & 9 fatty acids, Vitamins A, D and E. Hypoallergenic and suitable for all skin types.
Jojoba Oil 60ml


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The development of optical microscopy techniques for the advancement of single-particle studies
Degree Type
Date of Award
Degree Name
Doctor of Philosophy
First Advisor
Ning Fang
Single particle orientation and rotational tracking (SPORT) has recently become a powerful optical microscopy tool that can expose many molecular motions. Unfortunately, there is not yet a single microscopy technique that can decipher all particle motions in all environmental conditions, thus there are limitations to current technologies. Within, the two powerful microscopy tools of total internal reflection and interferometry are advanced to determine the position, orientation, and optical properties of metallic nanoparticles in a variety of environments.
Total internal reflection is an optical phenomenon that has been applied to microscopy to produce either fluorescent or scattered light. The non-invasive far-field imaging technique is coupled with a near-field illumination scheme that allows for better axial resolution than confocal microscopy and epi-fluorescence microscopy. By controlling the incident illumination angle using total internal reflection fluorescence (TIRF) microscopy, a new type of imaging probe called "non-blinking" quantum dots (NBQDs) were super-localized in the axial direction to sub-10-nm precision. These particles were also used to study the rotational motion of microtubules being propelled by the motor protein kinesin across the substrate surface.
The same instrument was modified to function under total internal reflection scattering (TIRS) microscopy to study metallic anisotropic nanoparticles and their dynamic interactions with synthetic lipid bilayers. Utilizing two illumination lasers with opposite polarization directions at wavelengths corresponding to the short and long axis surface plasmon resonance (SPR) of the nanoparticles, both the in-plane and out-of-plane movements of many particles could be tracked simultaneously. When combined with Gaussian point spread function (PSF) fitting for particle super-localization, the binding status and rotational movement could be resolved without degeneracy.
TIRS microscopy was also used to find the 3D orientation of stationary metallic anisotropic nanoparticles utilizing only long-axis SPR enhancement. The polarization direction of the illuminating light was rotated causing the relative intensity of p-polarized and s-polarized light within the evanescent field to change. The interaction of the evanescent field with the particles is dependent on the orientation of the particle producing an intensity curve. This curve and the in-plane angle can be compared with simulations to accurately determine the 3D orientation.
Differential interference contrast (DIC) microscopy is another non-invasive far-field technique based upon interferometry that does not rely on staining or other contrast enhancing techniques. In addition, high numerical aperture condensers and objectives can be used to give a very narrow depth of field allowing for the optical tomography of samples, which makes it an ideal candidate to study biological systems. DIC microscopy has also proven itself in determining the orientation of gold nanorods in both engineered environments and within cells.
Many types of nanoparticles and nanostructures have been synthesized using lithographic techniques on silicon wafer substrates. Traditionally, reflective mode DIC microscopes have been developed and applied to the topographical study of reflective substrates and the imaging of chips on silicon wafers. Herein, a laser-illuminated reflected-mode DIC was developed for studying nanoparticles on reflective surfaces.
Copyright Owner
Kyle Marchuk
Copyright Date
File Format
File Size
115 pages
Recommended Citation
Marchuk, Kyle, "The development of optical microscopy techniques for the advancement of single-particle studies" (2013). Graduate Theses and Dissertations. 13275.


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Posted on :
4 Apr, 2018
4 Apr, 2018
Deliver superior customer experience through enhanced accounts management within the ISP and Bulk bandwidth sector in order to maintain and grow accounts in line with approved sales targets/plans. The key mandate of this role is to grow MTN's wallet share of the ISP and Bulk bandwidth market through superior service delivery and support.
Job Description
Job Title: Manager, EB Key Accounts
Job Role
Skills & Physical Competencies:
How to Apply
Interested and qualified applicants should send their Curriculum Vitae by 5th April 2018 to:
Email: [email protected]
Kindly indicate the Position in the subject and note that only shortlisted applicants will be contacted


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BruinTHON 2016 nets $12,000 for hospital
After eight hours of non-stop dancing, playing games and staying on their feet, Saint Joseph students raised more than $12,000 for the Blaire E. Batson Children's Hospital in Jackson. BruinTHON, formerly called Dance Marathon, took place Friday, April 29, 2016. It began after school and lasted until midnight.
Money raised from the event helped pay for toys and other necessities which patients may need or want. One of Batson's main goals is to keep their patients and kids' families comfortable.
While the main event is the BruinTHON itself, organizers also raised money for Blaire E. Batson throughout the year. One way was March 17 when the BruinTHON committee held a 3-on-3 basketball tournament. Maddy Davis, a 2016 senior who chaired the BruinTHON committee, had been involved with the program for two years.
"It's the most rewarding thing I've ever done," Davis said. "It's something that will stick with me for the rest of my life."
BruinTHON is completely student run with help from Mrs. Mary Banks, the Saint Joseph campus minister. BruinTHON is part of a nationwide movement involving high school and college students at more than 150 schools across the country -- all raising money for the Children's Miracle Network Hospital in their community.
The fundraising year culminates with an eight hour event each spring in which our St. Joe students stay on their feet through dancing, games and entertainment.


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Template:Lachdanan's Scroll
From Diablo Wiki
|Scrolls 1 - 5 are found in Act I in the Cathedral on a scribe's lectern[e]
|Found on Quest
|My name is Lachdanan, and I am cursed. Once the captain of King Leoric's army, I lived only to honor my land and my king. No man has a greater love for his king than I had for mine, even as I drove my blade through his dark and corrupted heart.
|The Legacy of Cain
|It was Lazarus - of that I am certain. He alone had the king's ear and whispered dark and evil magics into it, instilling the notion of an imminent attack by Westmarch. Afraid to speak against the archbishop, the councillors nodded their empty heads in agreement and sent us off to die.
|The Legacy of Cain
|When we returned from our horrific defeat in Westmarch, my beloved king lost all pertense of sanity. He seethed with rage, spitting curses upon us as traitors. With great sorrow I ran him through.
|The Legacy of Cain
|I will forever live in anguish for my last attempt to honor my king. As we lay him to rest in his burial chamber, he manifested as a hideous skeletal demon. Gorash and my other knights were overcome at once, but I fought on.
|The Legacy of Cain
|And now I wander, cursed by my once-beloved king. Evil gnaws at my bones, and I cannot risk putting my beloved Tristram in danger should I fail to contain that which tears at me. I must venture down into the labyrinth to die alone.
|The Legacy of Cain


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Speeding Police Kill Motorist, Charge Man They Were Chasing
Not so good at taking responsibility
A 20-year-old man who led police on a high-speed chase Wednesday was charged with the death of a motorist who was accidentally struck and killed by officers pursuing him.
Timothy Jones, of the 12500 block of South Union Avenue, was charged with the death of 59-year-old Chicago resident Jacqueline Reynolds, according to a statement release by Chicago police early Friday.
In addition to a murder charge, Jones also faces one count of home invasion, one count of leaving the scene of an accident and one count of fleeing from police officers, according to the statement.


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This day's skin cancer selfie brings about another one week milestone. One week ago today I was able to remove this glorious bandaging: Wasn't it lovely? I had my husband remove it and remember asking him what it looked like. I didnt dare look in the mirror first. I was so nervous. So very nervous. Was it going to look horrible? Was it going to be everything that I imagined? When I View Post
Skin Cancer Selfie: Day 9
On this day of the skin cancer selfie it has been one week since the repair. I think for a week things are looking so much better. Don't you think? Skin Cancer Selfie: Day 9 My eye is a a little red today and I'm not really sure what that's about. Probaby just tired. Yes, it's pretty good I think. Healing nicely and definitely looking less noticeable. Yesterday the little miss had a View Post
Skin Cancer Selfie: Day 8
I know that I sounded so very elated in yesterday's skin cancer selfie. I truly was. The post-op appointment was everything that I could have hoped for. The surgeon was happy with the it's healing. But here I sit back at home and the worries of before start to seep back in. I'm analyzing the entire appointment. Was the surgeon happy with the way it looked or did he simply mean that the wound View Post
Skin Cancer Selfie: Day 7
It's my skin cancer selfie lucky #7 and I'm feeling ever so lucky! I've got some really dandy news to share. Gals like me need all the dandy news we can get. Saw the surgeon this morning and he said that I'm really healing up real well. He was quite pleased with the results thus far especially considering the fact that it has only been since Thursday. Now that gives me something to smile View Post
Skin Cancer Selfie: Day 6
On this day's skin cancer selfie I'm still looking a little yellow. Very similar to Day 5 actually. So definitely less on the black and blue now. I'm still feeling a little yellow too. It was back to work for me and a Monday so that's kind of a yellow kinda day anyway. Right? So here I am just trying to get back into my life and my current new look. Skin Cancer Selfie: Day 6 I did leave View Post
Skin Cancer Selfie: Day 5 Feeling Yellow
I'm feeling yellow on this Day 5 skin care selfie. Day 5. I can't believe I'm already here and yet still not ready to face the world. Believe me when I say that it's so much easier to share my new look from behind the computer. I didn't go to church today. Just not ready to brave the crowds without makeup. Makeup allows a woman to hide. I'll use it to eventually cover the scarring but for View Post
Skin Cancer Selfie: Day 4
I decided to come back today with another skin cancer selfie. I know I said that I would but believe me when I say that it's hard to do. I didn't realize that it would be this difficult. To not only see what I look like in this moment but to show others at the same time. My goal is to prevent someone else from making my mistakes. I thought it was okay to be tan. I thought it was healthy. I View Post
Skin Cancer Selfies: Day 1, 2, & 3
My skin cancer selfies could be a lot worse. I know that. At the same time it could be not at all. If I hadn't spent all those years tanning. If I hadn't neglected the use of sunscreen. If I hadn't… But I did. Now I'm left with all the repercussions and the fact that there will be more. Sure that one spot of basal cell carcinoma has been fully removed. I'll just heal up and have to live View Post


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The term epidemiology is defined as the science of the study of disease patterns. The correct term which refers to the epidemiology of animal diseases is epizootiology, however this term is not in common use.
The department collects and tracks reports of animal disease. The department summarizes disease outbreaks, tracks the disease patterns, and compares them with information from previous years. The department publishes periodical reports of disease patterns addressed to the entire public and the veterinary doctors.
The department regularly submits reports concerning the spread of animal disease in Israel r, and in cases of unusual disease outbreaks, to the OIE (which is the World Organization for Animal Health), the European Union and other relevant countries.
The epidemiology department mainly focuses its attention on contagious animal diseases, on zoonoses (diseases which are transferred from animals to human beings) and diseases which have a great economic effect on the various animal industries.
At times of animal disease outbreaks the department produces maps which assist in making decisions concerning methods to control the disease and preventing its spread.
In addition, the maps provide important tools for understanding the spreading patterns of the various diseases.
At times of unusual outbreaks, the department performs extensive epidemiological (epizootiological) investigations in order to trace the origin of the disease and the patterns in which it might have spread.


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This Eureka serving bowl is perfect as day to day large serving bowl, as well as special occasion decorative centerpiece when you want to make an impression.
Eureka is our signature series using inlay technique to create simple strokes.
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